WorldWideScience

Sample records for met office unified

  1. The performance of FLake in the Met Office Unified Model

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    Gabriel Gerard Rooney

    2013-12-01

    Full Text Available We present results from the coupling of FLake to the Met Office Unified Model (MetUM. The coupling and initialisation are first described, and the results of testing the coupled model in local and global model configurations are presented. These show that FLake has a small statistical impact on screen temperature, but has the potential to modify the weather in the vicinity of areas of significant inland water. Examination of FLake lake ice has revealed that the behaviour of lakes in the coupled model is unrealistic in some areas of significant sub-grid orography. Tests of various modifications to ameliorate this behaviour are presented. The results indicate which of the possible model changes best improve the annual cycle of lake ice. As FLake has been developed and tuned entirely outside the Unified Model system, these results can be interpreted as a useful objective measure of the performance of the Unified Model in terms of its near-surface characteristics.

  2. Exoplanet modelling with the Met Office Unified Model

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    Boutle, Ian; Lines, Stefan; Mayne, Nathan; Lee, Graham; Helling, Christiane; Drummond, Ben; Manners, James; Goyal, Jayesh; Lambert, Hugo; Acreman, David; Earnshaw, Paul; Amundsen, David; Baraffe, Isabelle

    2017-04-01

    This talk will present an overview of work being done to adapt the Unified Model, one of the most sophisticated weather and climate models of this planet, into a flexible planet simulator for use in the study of any exoplanet. We will focus on two current projects: Clouds in hot Jupiter atmospheres - recent HST observations have revealed a continuum in atmospheric composition from cloudy to clear skies. The presence of clouds is inferred from a grey opacity in the near-IR that mutes key absorption features in the transmission spectra. Unlike the L-T Brown Dwarf sequence, this transition does not correlate well with equilibrium temperature, suggesting that a cloud formation scheme more comprehensive than simply considering the condensation temperature needed for homogenous cloud growth, is required. In our work, we conduct 3D simulations of cloud nucleation, growth, advection, evaporation and gravitational settling in the atmospheres of HD209458b and HD189733 using the kinetic and mixed-grain cloud formation code DIHRT, coupled to the Unified Model. We explore cloud composition, vertical structure and particle sizes, as well as highlighting the importance of the strong atmospheric dynamics seen in tidally locked hot Jupiters on the evolution and distribution of the cloud. Climate of Proxima B - we present results of simulations of the climate of the newly discovered planet Proxima Centauri B, examining the responses of both an `Earth-like' atmosphere and simplified nitrogen and trace carbon dioxide atmosphere to the radiation likely received. Overall, our results are in agreement with previous studies in suggesting Proxima Centauri B may well have surface temperatures conducive to the presence of liquid water. Moreover, we have expanded the parameter regime over which the planet may support liquid water to higher values of eccentricity and lower incident fluxes, guided by observational constraints. This increased parameter space arises because of the low sensitivity

  3. Using Machine Learning as a fast emulator of physical processes within the Met Office's Unified Model

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    Prudden, R.; Arribas, A.; Tomlinson, J.; Robinson, N.

    2017-12-01

    The Unified Model is a numerical model of the atmosphere used at the UK Met Office (and numerous partner organisations including Korean Meteorological Agency, Australian Bureau of Meteorology and US Air Force) for both weather and climate applications.Especifically, dynamical models such as the Unified Model are now a central part of weather forecasting. Starting from basic physical laws, these models make it possible to predict events such as storms before they have even begun to form. The Unified Model can be simply described as having two components: one component solves the navier-stokes equations (usually referred to as the "dynamics"); the other solves relevant sub-grid physical processes (usually referred to as the "physics"). Running weather forecasts requires substantial computing resources - for example, the UK Met Office operates the largest operational High Performance Computer in Europe - and the cost of a typical simulation is spent roughly 50% in the "dynamics" and 50% in the "physics". Therefore there is a high incentive to reduce cost of weather forecasts and Machine Learning is a possible option because, once a machine learning model has been trained, it is often much faster to run than a full simulation. This is the motivation for a technique called model emulation, the idea being to build a fast statistical model which closely approximates a far more expensive simulation. In this paper we discuss the use of Machine Learning as an emulator to replace the "physics" component of the Unified Model. Various approaches and options will be presented and the implications for further model development, operational running of forecasting systems, development of data assimilation schemes, and development of ensemble prediction techniques will be discussed.

  4. The East Asian Atmospheric Water Cycle and Monsoon Circulation in the Met Office Unified Model

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    Rodríguez, José M.; Milton, Sean F.; Marzin, Charline

    2017-10-01

    In this study the low-level monsoon circulation and observed sources of moisture responsible for the maintenance and seasonal evolution of the East Asian monsoon are examined, studying the detailed water budget components. These observational estimates are contrasted with the Met Office Unified Model (MetUM) climate simulation performance in capturing the circulation and water cycle at a variety of model horizontal resolutions and in fully coupled ocean-atmosphere simulations. We study the role of large-scale circulation in determining the hydrological cycle by analyzing key systematic errors in the model simulations. MetUM climate simulations exhibit robust circulation errors, including a weakening of the summer west Pacific Subtropical High, which leads to an underestimation of the southwesterly monsoon flow over the region. Precipitation and implied diabatic heating biases in the South Asian monsoon and Maritime Continent region are shown, via nudging sensitivity experiments, to have an impact on the East Asian monsoon circulation. By inference, the improvement of these tropical biases with increased model horizontal resolution is hypothesized to be a factor in improvements seen over East Asia with increased resolution. Results from the annual cycle of the hydrological budget components in five domains show a good agreement between MetUM simulations and ERA-Interim reanalysis in northern and Tibetan domains. In simulations, the contribution from moisture convergence is larger than in reanalysis, and they display less precipitation recycling over land. The errors are closely linked to monsoon circulation biases.

  5. The HadGEM2 family of Met Office Unified Model climate configurations

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    The HadGEM2 Development Team: G. M. Martin

    2011-09-01

    Full Text Available We describe the HadGEM2 family of climate configurations of the Met Office Unified Model, MetUM. The concept of a model "family" comprises a range of specific model configurations incorporating different levels of complexity but with a common physical framework. The HadGEM2 family of configurations includes atmosphere and ocean components, with and without a vertical extension to include a well-resolved stratosphere, and an Earth-System (ES component which includes dynamic vegetation, ocean biology and atmospheric chemistry. The HadGEM2 physical model includes improvements designed to address specific systematic errors encountered in the previous climate configuration, HadGEM1, namely Northern Hemisphere continental temperature biases and tropical sea surface temperature biases and poor variability. Targeting these biases was crucial in order that the ES configuration could represent important biogeochemical climate feedbacks. Detailed descriptions and evaluations of particular HadGEM2 family members are included in a number of other publications, and the discussion here is limited to a summary of the overall performance using a set of model metrics which compare the way in which the various configurations simulate present-day climate and its variability.

  6. MET Standards for Electro-Technical Officers

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    Janusz Mindykowski

    2014-12-01

    Full Text Available The paper deals with one of the most important changes in the STCW 1978 as amended in 2010 Convention, from the point of view of the watchkeeping officers responsible for control, maintenance, diagnostic and repair of electrical and electronic installations on board of ships. Some reasons, why the MET Standards for Electro-Technical had to be developed and implemented are shortly analyzed and described. A legislative way towards and a short description of the minimum standards competence for ETO are presented. Next, new tools supporting ETO’s standards implementation are appointed. Finally, the future works as well as the concluding remarks concerning discussed issue are formulated and commented on.

  7. Operational assimilation of ASCAT surface soil wetness at the Met Office

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    I. Dharssi

    2011-08-01

    Full Text Available Currently, no extensive, near real time, global soil moisture observation network exists. Therefore, the Met Office global soil moisture analysis scheme has instead used observations of screen temperature and humidity. A number of new space-borne remote sensing systems, operating at microwave frequencies, have been developed that provide a more direct retrieval of surface soil moisture. These systems are attractive since they provide global data coverage and the horizontal resolution is similar to weather forecasting models. Several studies show that measurements of normalised backscatter (surface soil wetness from the Advanced Scatterometer (ASCAT on the meteorological operational (MetOp satellite contain good quality information about surface soil moisture. This study describes methods to convert ASCAT surface soil wetness measurements to volumetric surface soil moisture together with bias correction and quality control. A computationally efficient nudging scheme is used to assimilate the ASCAT volumetric surface soil moisture data into the Met Office global soil moisture analysis. This ASCAT nudging scheme works alongside a soil moisture nudging scheme that uses observations of screen temperature and humidity. Trials, using the Met Office global Unified Model, of the ASCAT nudging scheme show a positive impact on forecasts of screen temperature and humidity for the tropics, North America and Australia. A comparison with in-situ soil moisture measurements from the US also indicates that assimilation of ASCAT surface soil wetness improves the soil moisture analysis. Assimilation of ASCAT surface soil wetness measurements became operational during July 2010.

  8. Remote Sensing of Volcanic ASH at the Met Office

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    Marenco F.

    2016-01-01

    Full Text Available The eruption of Eyjafjallajökull in 2010 has triggered the rapid development of volcanic ash remote sensing activities at the Met Office. Volcanic ash qualitative and quantitative mapping have been achieved using lidar on board the Facility for Airborne Atmospheric Measurements (FAAM research aircraft, and using improved satellite retrieval algorithms. After the eruption, a new aircraft facility, the Met Office Civil Contingencies Aircraft (MOCCA, has been set up to enable a rapid response, and a network of ground-based remote sensing sites with lidars and sunphotometers is currently being developed. Thanks to these efforts, the United Kingdom (UK will be much better equipped to deal with such a crisis, should it happen in the future.

  9. Operational Use of OGC Web Services at the Met Office

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    Wright, Bruce

    2010-05-01

    The Met Office has adopted the Service-Orientated Architecture paradigm to deliver services to a range of customers through Rich Internet Applications (RIAs). The approach uses standard Open Geospatial Consortium (OGC) web services to provide information to web-based applications through a range of generic data services. "Invent", the Met Office beta site, is used to showcase Met Office future plans for presenting web-based weather forecasts, product and information to the public. This currently hosts a freely accessible Weather Map Viewer, written in JavaScript, which accesses a Web Map Service (WMS), to deliver innovative web-based visualizations of weather and its potential impacts to the public. The intention is to engage the public in the development of new web-based services that more accurately meet their needs. As the service is intended for public use within the UK, it has been designed to support a user base of 5 million, the analysed level of UK web traffic reaching the Met Office's public weather information site. The required scalability has been realised through the use of multi-tier tile caching: - WMS requests are made for 256x256 tiles for fixed areas and zoom levels; - a Tile Cache, developed in house, efficiently serves tiles on demand, managing WMS request for the new tiles; - Edge Servers, externally hosted by Akamai, provide a highly scalable (UK-centric) service for pre-cached tiles, passing new requests to the Tile Cache; - the Invent Weather Map Viewer uses the Google Maps API to request tiles from Edge Servers. (We would expect to make use of the Web Map Tiling Service, when it becomes an OGC standard.) The Met Office delivers specialist commercial products to market sectors such as transport, utilities and defence, which exploit a Web Feature Service (WFS) for data relating forecasts and observations to specific geographic features, and a Web Coverage Service (WCS) for sub-selections of gridded data. These are locally rendered as maps or

  10. Sandscape - engaging people in Met Office science through sand sculpture

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    Liggins, Felicity; Dowell, Ellen; Wardley, Jamie; Jamieson, Claire

    2017-04-01

    In 2015, the Met Office's award-winning outreach programme, designed to inspire the next generation of scientists and engineers, delivered one of its most ambitious and creative activities to date. It explored how scientists and artists can come together to create an engaging experience for young people and families. This activity was called Sandscape. Sandscape is an interactive sand sculpture workshop exploring how weather and climate affect our health. Budding sand sculptors are shown how to fashion elaborate structures from sand and water - creating a landscape with bridges, skyscrapers, forests and factories. As they work, participants are encouraged by the scientists delivering the activity to reflect on what makes a healthy city, considering how the natural and built environments influence air quality and circulation and how this impacts our health. Topics discussed include urban heat islands, air pollution and dispersion modelling, pollen forecasting and predicting the wind-borne spread of animal diseases. Each hour long workshop culminates in a dramatic demonstration that uses dry ice to represent clean air circulating from mountains, along rivers and into cities. Here we present an overview of Sandscape, identify the strengths and challenges of such a collaborative, innovative and playful approach to public engagement and share the results of our evaluation. Sandscape was originally supported by the Met Office and the Wellcome Trust, and produced by Einstein's Garden in collaboration with the Met Office, scientists from the University of Exeter and sand sculptors from Sand in Your Eye. It was first presented in Einstein's Garden at Green Man festival 2015, an independent music and arts festival held annually in Wales, and has since been invited to run at the 2015 Bournemouth Arts By the Sea Festival and Teignmouth's TRAIL Sculpture Festival in the summer of 2016.

  11. Verification of space weather forecasts at the UK Met Office

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    Bingham, S.; Sharpe, M.; Jackson, D.; Murray, S.

    2017-12-01

    The UK Met Office Space Weather Operations Centre (MOSWOC) has produced space weather guidance twice a day since its official opening in 2014. Guidance includes 4-day probabilistic forecasts of X-ray flares, geomagnetic storms, high-energy electron events and high-energy proton events. Evaluation of such forecasts is important to forecasters, stakeholders, model developers and users to understand the performance of these forecasts and also strengths and weaknesses to enable further development. Met Office terrestrial near real-time verification systems have been adapted to provide verification of X-ray flare and geomagnetic storm forecasts. Verification is updated daily to produce Relative Operating Characteristic (ROC) curves and Reliability diagrams, and rolling Ranked Probability Skill Scores (RPSSs) thus providing understanding of forecast performance and skill. Results suggest that the MOSWOC issued X-ray flare forecasts are usually not statistically significantly better than a benchmark climatological forecast (where the climatology is based on observations from the previous few months). By contrast, the issued geomagnetic storm activity forecast typically performs better against this climatological benchmark.

  12. The new Met Office strategy for seasonal forecasts

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    Hewson, T. D.

    2012-04-01

    In October 2011 the Met Office began issuing a new-format UK seasonal forecast, called "The 3-month Outlook". Government interest in a UK-relevant product had been heightened by infrastructure issues arising during the severe cold of previous winters. At the same time there was evidence that the Met Office's "GLOSEA4" long range forecasting system exhibited some hindcast skill for the UK, that was comparable to its hindcast skill for the larger (and therefore less useful) 'northern Europe' region. Also, the NAO- and AO- signals prevailing in the previous two winters had been highlighted by the GLOSEA4 model well in advance. This presentation will initially give a brief overview of GLOSEA4, describing key features such as evolving sea-ice, a well-resolved stratosphere, and the perturbation strategy. Skill measures will be shown, along with forecasts for the last 3 winters. The new structure 3-month outlook will then be described and presented. Previously, our seasonal forecasts had been based on a tercile approach. The new format outlook aims to substantially improve upon this by illustrating graphically, and with text, the full range of possible outcomes, and by placing those outcomes in the context of climatology. In one key component the forecast pdfs (probability density functions) are displayed alongside climatological pdfs. To generate the forecast pdf we take the bias-corrected GLOSEA4 output (42 members), and then incorporate, via expert team, all other relevant information. Firstly model forecasts from other centres are examined. Then external 'forcing factors', such as solar, and the state of the land-ocean-ice system, are referenced, assessing how well the models represent their influence, and bringing in statistical relationships where appropriate. The expert team thereby decides upon any changes to the GLOSEA4 data, employing an interactive tool to shift, expand or contract the forecast pdfs accordingly. The full modification process will be illustrated

  13. A new Infrared Atmospheric Sounding Interferometer channel selection and assessment of its impact on Met Office NWP forecasts

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    Noh, Young-Chan; Sohn, Byung-Ju; Kim, Yoonjae; Joo, Sangwon; Bell, William; Saunders, Roger

    2017-11-01

    A new set of Infrared Atmospheric Sounding Interferometer (IASI) channels was re-selected from 314 EUMETSAT channels. In selecting channels, we calculated the impact of the individually added channel on the improvement in the analysis outputs from a one-dimensional variational analysis (1D-Var) for the Unified Model (UM) data assimilation system at the Met Office, using the channel score index (CSI) as a figure of merit. Then, 200 channels were selected in order by counting each individual channel's CSI contribution. Compared with the operationally used 183 channels for the UM at the Met Office, the new set shares 149 channels, while the other 51 channels are new. Also examined is the selection from the entropy reduction method with the same 1D-Var approach. Results suggest that channel selection can be made in a more objective fashion using the proposed CSI method. This is because the most important channels can be selected across the whole IASI observation spectrum. In the experimental trial runs using the UM global assimilation system, the new channels had an overall neutral impact in terms of improvement in forecasts, as compared with results from the operational channels. However, upper-tropospheric moist biases shown in the control run with operational channels were significantly reduced in the experimental trial with the newly selected channels. The reduction of moist biases was mainly due to the additional water vapor channels, which are sensitive to the upper-tropospheric water vapor.

  14. Design and implementation of the infrastructure of HadGEM3: the next-generation Met Office climate modelling system

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    H. T. Hewitt

    2011-04-01

    Full Text Available This paper describes the development of a technically robust climate modelling system, HadGEM3, which couples the Met Office Unified Model atmosphere component, the NEMO ocean model and the Los Alamos sea ice model (CICE using the OASIS coupler. Details of the coupling and technical solutions of the physical model (HadGEM3-AO are documented, in addition to a description of the configurations of the individual submodels. The paper demonstrates that the implementation of the model has resulted in accurate conservation of heat and freshwater across the model components. The model performance in early versions of this climate model is briefly described to demonstrate that the results are scientifically credible. HadGEM3-AO is the basis for a number of modelling efforts outside of the Met Office, both within the UK and internationally. This documentation of the HadGEM3-AO system provides a detailed reference for developers of HadGEM3-based climate configurations.

  15. The Met Office Coupled Atmosphere/Land/Ocean/Sea-Ice Data Assimilation System

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    Lea, Daniel; Mirouze, Isabelle; King, Robert; Martin, Matthew; Hines, Adrian

    2015-04-01

    The Met Office has developed a weakly-coupled data assimilation (DA) system using the global coupled model HadGEM3 (Hadley Centre Global Environment Model, version 3). At present the analysis from separate ocean and atmosphere DA systems are combined to produced coupled forecasts. The aim of coupled DA is to produce a more consistent analysis for coupled forecasts which may lead to less initialisation shock and improved forecast performance. The HadGEM3 coupled model combines the atmospheric model UM (Unified Model) at 60 km horizontal resolution on 85 vertical levels, the ocean model NEMO (Nucleus for European Modelling of the Ocean) at 25 km (at the equator) horizontal resolution on 75 vertical levels, and the sea-ice model CICE at the same resolution as NEMO. The atmosphere and the ocean/sea-ice fields are coupled every 1-hour using the OASIS coupler. The coupled model is corrected using two separate 6-hour window data assimilation systems: a 4D-Var for the atmosphere with associated soil moisture content nudging and snow analysis schemes on the one hand, and a 3D-Var FGAT for the ocean and sea-ice on the other hand. The background information in the DA systems comes from a previous 6-hour forecast of the coupled model. To isolate the impact of the coupled DA, 13-month experiments have been carried out, including 1) a full atmosphere/land/ocean/sea-ice coupled DA run, 2) an atmosphere-only run forced by OSTIA SSTs and sea-ice with atmosphere and land DA, and 3) an ocean-only run forced by atmospheric fields from run 2 with ocean and sea-ice DA. In addition, 5-day and 10-day forecast runs, have been produced from initial conditions generated by either run 1 or a combination of runs 2 and 3. The different results have been compared to each other and, whenever possible, to other references such as the Met Office atmosphere and ocean operational analyses or the OSTIA SST data. The performance of the coupled DA is similar to the existing separate ocean and atmosphere

  16. Semi-implicit semi-Lagrangian modelling of the atmosphere: a Met Office perspective

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    Benacchio Tommaso

    2016-09-01

    Full Text Available The semi-Lagrangian numerical method, in conjunction with semi-implicit time integration, provides numerical weather prediction models with numerical stability for large time steps, accurate modes of interest, and good representation of hydrostatic and geostrophic balance. Drawing on the legacy of dynamical cores at the Met Office, the use of the semi-implicit semi-Lagrangian method in an operational numerical weather prediction context is surveyed, together with details of the solution approach and associated issues and challenges. The numerical properties and performance of the current operational version of the Met Office’s numerical model are then investigated in a simplified setting along with the impact of different modelling choices.

  17. Teaching weather and climate science in primary schools - a pilot project from the UK Met Office

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    Orrell, Richard; Liggins, Felicity; Challenger, Lesley; Lethem, Dom; Campbell, Katy

    2017-04-01

    Wow Schools is a pilot project from the Met Office with an aim to inspire and educate the next generation of scientists and, uniquely, use the data collected by schools to improve weather forecasts and warnings across the UK. Wow Schools was launched in late 2015 with a competition open to primary schools across the UK. 74 schools entered the draw, all hoping to be picked as one of the ten lucky schools taking part in the pilot scheme. Each winning school received a fully automatic weather station (AWS), enabling them to transmit real-time local weather observations to the Met Office's Weather Observation Website (WOW - wow.metoffice.gov.uk), an award winning web portal for uploading and sharing a range of environmental observations. They were also given a package of materials designed to get students out of the classroom to observe the weather, get hands-on with the science underpinning weather forecasting, and analyse the data they are collecting. The curriculum-relevant materials were designed with the age group 7 to 11 in mind, but could be extended to support other age groups. Each school was offered a visit by a Wow Schools Ambassador (a Met Office employee) to bring the students' learning to life, and access to a dedicated forecast for its location generated by our new supercomputer. These forecasts are improved by the school's onsite AWS reinforcing the link between observations and forecast production. The Wow Schools pilot ran throughout 2016. Here, we present the initial findings of the project, examining the potential benefits and challenges of working with schools across the UK to: enrich students' understanding of the science of weather forecasting; to source an ongoing supply of weather observations and discover how these might be used in the forecasting process; and explore what materials and business model(s) would be most useful and affordable if a wider roll-out of the initiative was undertaken.

  18. An Assessment of Data from the Advanced Technology Microwave Sounder at the Met Office

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    Amy Doherty

    2015-01-01

    Full Text Available An appraisal of the Advanced Technology Microwave Sounder (ATMS for use in numerical weather prediction (NWP is presented, including an assessment of the data quality, the impact on Met Office global forecasts in preoperational trials, and a summary of performance over a period of 17 months operational use. After remapping, the noise performance (NEΔT of the tropospheric temperature sounding channels is evaluated to be approximately 0.1 K, comparing favourably with AMSU-A. However, the noise is not random, differences between observations and simulations based on short-range forecast fields show a spurious striping effect, due to 1/f noise in the receiver. The amplitude of this signal is several tenths of a Kelvin, potentially a concern for NWP applications. In preoperational tests, adding ATMS data to a full Met Office system already exploiting data from four microwave sounders improves southern hemisphere mean sea level pressure forecasts in the 2- to 5-day range by 1-2%. In operational use, where data from five other microwave sounders is assimilated, forecast impact is typically between −0.05 and −0.1 J/kg (3.4% of total mean impact per day over the period 1 April to 31 July 2013. This suggests benefits beyond redundancy, associated with reducing already small analysis errors.

  19. Evaluation of stratocumulus cloud prediction in the Met Office forecast model during VOCALS-REx

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    S. J. Abel

    2010-11-01

    Full Text Available Observations in the subtropical southeast Pacific obtained during the VOCALS-REx field experiment are used to evaluate the representation of stratocumulus cloud in the Met Office forecast model and to identify key areas where model biases exist. Marked variations in the large scale structure of the cloud field were observed during the experiment on both day-to-day and on diurnal timescales. In the remote maritime region the model is shown to have a good representation of synoptically induced variability in both cloud cover and marine boundary layer depth. Satellite observations show a strong diurnal cycle in cloud fraction and liquid water path in the stratocumulus with enhanced clearances of the cloud deck along the Chilean and Peruvian coasts on certain days. The model accurately simulates the phase of the diurnal cycle but is unable to capture the coastal clearing of cloud. Observations along the 20° S latitude line show a gradual increase in the depth of the boundary layer away from the coast. This trend is well captured by the model (typical low bias of 200 m although significant errors exist at the coast where the model marine boundary layer is too shallow and moist. Drizzle in the model responds to changes in liquid water path in a manner that is consistent with previous ship-borne observations in the region although the intensity of this drizzle is likely to be too high, particularly in the more polluted coastal region where higher cloud droplet number concentrations are typical. Another mode of variability in the cloud field that the model is unable to capture are regions of pockets of open cellular convection embedded in the overcast stratocumulus deck and an example of such a feature that was sampled during VOCALS-REx is shown.

  20. Towards a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking

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    Gabriele eBaj

    2013-10-01

    Full Text Available Brain-derived neurotrophic factor (BDNF represents promotesa key molecule for the survival and differentiation of specific populations of neurons in the central nervous system. BDNF also regulates plasticity-related processes underlying memory and learning. A common single nucleotide polymorphism (SNP rs6265 has been identified on the coding sequence of human BDNF located at 11p13. The SNP rs6265 is a single base mutation with an adenine instead of a guanine at position 196 (G196A, resulting in the amino acid substitution Val66Met. This polymorphism only exists in humans and has been associated with a plethora of effects ranging from molecular, cellular and brain structural modifications in association with deficits in social and cognitive functions. To date, the literature on Val66Met polymorphism describes a complex and often conflicting pattern of effects. In this review, we attempt to provide a unifying model of the Val66Met effects. We discuss the clinical evidence of the association between Val66Met and memory deficits, as well as the molecular mechanisms involved including the reduced transport of BDNF mRNA to the dendrites as well as the reduced processing and secretion of BDNF protein through the regulated secretory pathway.

  1. The Met Office Global Coupled Model 3.0 and 3.1 (GC3.0 and GC3.1) Configurations

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    Williams, K. D.; Copsey, D.; Blockley, E. W.; Bodas-Salcedo, A.; Calvert, D.; Comer, R.; Davis, P.; Graham, T.; Hewitt, H. T.; Hill, R.; Hyder, P.; Ineson, S.; Johns, T. C.; Keen, A. B.; Lee, R. W.; Megann, A.; Milton, S. F.; Rae, J. G. L.; Roberts, M. J.; Scaife, A. A.; Schiemann, R.; Storkey, D.; Thorpe, L.; Watterson, I. G.; Walters, D. N.; West, A.; Wood, R. A.; Woollings, T.; Xavier, P. K.

    2018-02-01

    The Global Coupled 3 (GC3) configuration of the Met Office Unified Model is presented. Among other applications, GC3 is the basis of the United Kingdom's submission to the Coupled Model Intercomparison Project 6 (CMIP6). This paper documents the model components that make up the configuration (although the scientific descriptions of these components are in companion papers) and details the coupling between them. The performance of GC3 is assessed in terms of mean biases and variability in long climate simulations using present-day forcing. The suitability of the configuration for predictability on shorter time scales (weather and seasonal forecasting) is also briefly discussed. The performance of GC3 is compared against GC2, the previous Met Office coupled model configuration, and against an older configuration (HadGEM2-AO) which was the submission to CMIP5. In many respects, the performance of GC3 is comparable with GC2, however, there is a notable improvement in the Southern Ocean warm sea surface temperature bias which has been reduced by 75%, and there are improvements in cloud amount and some aspects of tropical variability. Relative to HadGEM2-AO, many aspects of the present-day climate are improved in GC3 including tropospheric and stratospheric temperature structure, most aspects of tropical and extratropical variability and top-of-atmosphere and surface fluxes. A number of outstanding errors are identified including a residual asymmetric sea surface temperature bias (cool northern hemisphere, warm Southern Ocean), an overly strong global hydrological cycle and insufficient European blocking.

  2. From big data analysis in the cloud to robotic pot drumming: tales from the Met Office Informatics Lab

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    Robinson, Niall; Tomlinson, Jacob; Prudden, Rachel; Hilson, Alex; Arribas, Alberto

    2017-04-01

    The Met Office Informatics Lab is a small multidisciplinary team which sits between science, technology and design. Our mission is simply "to make Met Office data useful" - a deliberately broad objective. Our prototypes often trial cutting edge technologies, and so far have included projects such as virtual reality data visualisation in the web browser, bots and natural language interfaces, and artificially intelligent weather warnings. In this talk we focus on our latest project, Jade, a big data analysis platform in the cloud. It is a powerful, flexible and simple to use implementation which makes extensive use of technologies such as Jupyter, Dask, containerisation, Infrastructure as Code, and auto-scaling. Crucially, Jade is flexible enough to be used for a diverse set of applications: it can present weather forecast information to meteorologists and allow climate scientists to analyse big data sets, but it is also effective for analysing non-geospatial data. As well as making data useful, the Informatics Lab also trials new working practises. In this presentation, we will talk about our experience of making a group like the Lab successful.

  3. Data Quality Assessment of FY-3C MWRI Microwave Imager from CMA, ECMWF and the Met Office

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    Lu, Q.; WU, S.; Dou, F.; Sun, F.; Lawrence, H.; Geer, A.; English, S.; Newman, S.; Bell, W.; Bormann, N.; Carminati, F.

    2017-12-01

    MWRI is a conical-scanning microwave imager following on from the heritage of similar instruments such as SSMI/S and AMSR-2, with ten channels at frequencies between 10.65 GHz and 89 GHz. MWRI is flown on the China Meteorological Administration's (CMA's) Feng-Yun-3 (FY-3) satellite series, including on FY-3C and the upcoming FY-3D, scheduled for launch in September 2017. Here we present an evaluation of the data from MWRI on the FY-3C satellite launched in 2013. At CMA, the MWRI instrumental parameters and statistics between observation and simulation from RTTOV and CRTM radiative transfer modeling were monitored to characterise instrumental uncertainty from calibration and assess the data quality. The data were also assessed using model-equivalent brightness temperatures from the ECMWF and Met Office short-range forecasts. The forecasts were first transformed into brightness temperature space using the RTTOV radiative transfer code. By analysing observed minus model background ("O-B") brightness temperature departures we were able to investigate the instrument and geophysical state dependence of biases. We show examples of how biases can impact the data quality, related to ascending/descending node differences and radio frequency interference. We discuss the prospects of assimilation of MWRI data at NWP centres.

  4. The SAO and Kelvin waves in the EuroGRIPS GCMS and the UK Met. Office analyses

    Directory of Open Access Journals (Sweden)

    M. Amodei

    Full Text Available We compare the tropical oscillations and planetary scale Kelvin waves in four troposphere-stratosphere climate models and the assimilated dataset produced by the United Kingdom Meteorological Office (UKMO. The comparison has been made in the GRIPS framework "GCM-Reality Intercomparison Project for SPARC", where SPARC is Stratospheric Processes and their Role in Climate, a project of the World Climate Research Program. The four models evaluated are European members of GRIPS: the UKMO Unified Model (UM, the model of the Free University in Berlin (FUB–GCM, the ARPEGE-climat model of the French National Centre for Meteorological Research (CNRM, and the Extended UGAMP GCM (EUGCM of the Centre for Global Atmospheric Modelling (CGAM. The integrations were performed with different, but annually periodic external conditions (e.g., sea-surface temperature, sea ice, and incoming solar radiation. The structure of the tropical winds and the strengths of the Kelvin waves are examined. In the analyses where the SAO (Semi-Annual Oscillation and the QBO (Quasi-Biennal Oscillation are reasonably well captured, the amplitude of these analysed Kelvin waves is close to that observed in independent data from UARS (Upper Atmosphere Research Satellite. In agreement with observations, the Kelvin waves generated in the models propagate into the middle atmosphere as wave packets, consistent with a convective forcing origin. In three of the models, slow Kelvin waves propagate too high and their amplitudes are overestimated in the upper stratosphere and in the mesosphere, the exception is the UM which has weaker waves. None of the modelled waves are sufficient to force realistic eastward phases of the QBO or SAO. Although the SAO is represented by all models, only two of them are able to generate westerlies between 10 hPa and 50 hPa. The importance of the role played in the SAO by unresolved gravity waves is emphasized. Although it exhibits some unrealistic features, the

  5. The SAO and Kelvin waves in the EuroGRIPS GCMS and the UK Met. Office analyses

    Directory of Open Access Journals (Sweden)

    M. Amodei

    2001-01-01

    Full Text Available We compare the tropical oscillations and planetary scale Kelvin waves in four troposphere-stratosphere climate models and the assimilated dataset produced by the United Kingdom Meteorological Office (UKMO. The comparison has been made in the GRIPS framework "GCM-Reality Intercomparison Project for SPARC", where SPARC is Stratospheric Processes and their Role in Climate, a project of the World Climate Research Program. The four models evaluated are European members of GRIPS: the UKMO Unified Model (UM, the model of the Free University in Berlin (FUB–GCM, the ARPEGE-climat model of the French National Centre for Meteorological Research (CNRM, and the Extended UGAMP GCM (EUGCM of the Centre for Global Atmospheric Modelling (CGAM. The integrations were performed with different, but annually periodic external conditions (e.g., sea-surface temperature, sea ice, and incoming solar radiation. The structure of the tropical winds and the strengths of the Kelvin waves are examined. In the analyses where the SAO (Semi-Annual Oscillation and the QBO (Quasi-Biennal Oscillation are reasonably well captured, the amplitude of these analysed Kelvin waves is close to that observed in independent data from UARS (Upper Atmosphere Research Satellite. In agreement with observations, the Kelvin waves generated in the models propagate into the middle atmosphere as wave packets, consistent with a convective forcing origin. In three of the models, slow Kelvin waves propagate too high and their amplitudes are overestimated in the upper stratosphere and in the mesosphere, the exception is the UM which has weaker waves. None of the modelled waves are sufficient to force realistic eastward phases of the QBO or SAO. Although the SAO is represented by all models, only two of them are able to generate westerlies between 10 hPa and 50 hPa. The importance of the role played in the SAO by unresolved gravity waves is emphasized. Although it exhibits some unrealistic features, the

  6. ACHP | Unified Federal Review

    Science.gov (United States)

    Search skip specific nav links Home arrow Unified Federal Review Three logos: 1) Executive Office of the Homeland Security. Unified Federal Environmental and Historic Preservation Review Process Please visit the new location for the Unified Federal Review located here: http://www.fema.gov/environmental-historic

  7. Improved scheme for parametrization of convection in the Met Office's Numerical Atmospheric-dispersion Modelling Environment (NAME)

    Science.gov (United States)

    Meneguz, Elena; Thomson, David; Witham, Claire; Kusmierczyk-Michulec, Jolanta

    2015-04-01

    NAME is a Lagrangian atmospheric dispersion model used by the Met Office to predict the dispersion of both natural and man-made contaminants in the atmosphere, e.g. volcanic ash, radioactive particles and chemical species. Atmospheric convection is responsible for transport and mixing of air resulting in a large exchange of heat and energy above the boundary layer. Although convection can transport material through the whole troposphere, convective clouds have a small horizontal length scale (of the order of few kilometres). Therefore, for large-scale transport the horizontal scale on which the convection exists is below the global NWP resolution used as input to NAME and convection must be parametrized. Prior to the work presented here, the enhanced vertical mixing generated by non-resolved convection was reproduced by randomly redistributing Lagrangian particles between the cloud base and cloud top with probability equal to 1/25th of the NWP predicted convective cloud fraction. Such a scheme is essentially diffusive and it does not make optimal use of all the information provided by the driving meteorological model. To make up for these shortcomings and make the parametrization more physically based, the convection scheme has been recently revised. The resulting version, presented in this paper, is now based on the balance equation between upward, entrainment and detrainment fluxes. In particular, upward mass fluxes are calculated with empirical formulas derived from Cloud Resolving Models and using the NWP convective precipitation diagnostic as closure. The fluxes are used to estimate how many particles entrain, move upward and detrain. Lastly, the scheme is completed by applying a compensating subsidence flux. The performance of the updated convection scheme is benchmarked against available observational data of passive tracers. In particular, radioxenon is a noble gas that can undergo significant long range transport: this study makes use of observations of

  8. The seasonal predictability of blocking frequency in two seasonal prediction systems (CMCC, Met-Office) and the associated representation of low-frequency variability.

    Science.gov (United States)

    Athanasiadis, Panos; Gualdi, Silvio; Scaife, Adam A.; Bellucci, Alessio; Hermanson, Leon; MacLachlan, Craig; Arribas, Alberto; Materia, Stefano; Borelli, Andrea

    2014-05-01

    Low-frequency variability is a fundamental component of the atmospheric circulation. Extratropical teleconnections, the occurrence of blocking and the slow modulation of the jet streams and storm tracks are all different aspects of low-frequency variability. Part of the latter is attributed to the chaotic nature of the atmosphere and is inherently unpredictable. On the other hand, primarily as a response to boundary forcings, tropospheric low-frequency variability includes components that are potentially predictable. Seasonal forecasting faces the difficult task of predicting these components. Particularly referring to the extratropics, the current generation of seasonal forecasting systems seem to be approaching this target by realistically initializing most components of the climate system, using higher resolution and utilizing large ensemble sizes. Two seasonal prediction systems (Met-Office GloSea and CMCC-SPS-v1.5) are analyzed in terms of their representation of different aspects of extratropical low-frequency variability. The current operational Met-Office system achieves unprecedented high scores in predicting the winter-mean phase of the North Atlantic Oscillation (NAO, corr. 0.74 at 500 hPa) and the Pacific-N. American pattern (PNA, corr. 0.82). The CMCC system, considering its small ensemble size and course resolution, also achieves good scores (0.42 for NAO, 0.51 for PNA). Despite these positive features, both models suffer from biases in low-frequency variance, particularly in the N. Atlantic. Consequently, it is found that their intrinsic variability patterns (sectoral EOFs) differ significantly from the observed, and the known teleconnections are underrepresented. Regarding the representation of N. hemisphere blocking, after bias correction both systems exhibit a realistic climatology of blocking frequency. In this assessment, instantaneous blocking and large-scale persistent blocking events are identified using daily geopotential height fields at

  9. Unified communications

    OpenAIRE

    Kravos, Urban

    2011-01-01

    In the modern business world, communication are becoming more and more complex. As a solution to this problem unified communications occurred. Using a single communication approach unified communications are the integration of various communication technologies (eg, telephony, unified messaging, audio, video and web conferencing and collaboration tools). Unified Messaging, which represents only part of the unified communications means the integration of different non real time communication t...

  10. Boreal summer sub-seasonal variability of the South Asian monsoon in the Met Office GloSea5 initialized coupled model

    Science.gov (United States)

    Jayakumar, A.; Turner, A. G.; Johnson, S. J.; Rajagopal, E. N.; Mohandas, Saji; Mitra, A. K.

    2017-09-01

    Boreal summer sub-seasonal variability in the Asian monsoon, otherwise known as the monsoon intra-seasonal oscillation (MISO), is one of the dominant modes of intraseasonal variability in the tropics, with large impacts on total monsoon rainfall and India's agricultural production. However, our understanding of the mechanisms involved in MISO is incomplete and its simulation in various numerical models is often flawed. In this study, we focus on the objective evaluation of the fidelity of MISO simulation in the Met Office Global Seasonal forecast system version 5 (GloSea5), an initialized coupled model. We analyze a series of nine-member hindcasts from GloSea5 over 1996-2009 during the peak monsoon period (July-August) over the South-Asian monsoon domain focusing on aspects of the time-mean background state and air-sea interaction processes pertinent to MISO. Dominant modes during this period are evident in power spectrum analysis, but propagation and evolution characteristics of the MISO are not realistic. We find that simulated air-sea interactions in the central Indian Ocean are not supportive of MISO initiation in that region, likely a result of the low surface wind variance there. As a consequence, the expected near-quadrature phase relationship between SST and convection is not represented properly over the central equatorial Indian Ocean, and northward propagation from the equator is poorly simulated. This may reinforce the equatorial rainfall mean state bias in GloSea5.

  11. Climate Variability over India and Bangladesh from the Perturbed UK Met Office Hadley Model: Impacts on Flow and Nutrient Fluxes in the Ganges Delta System

    Science.gov (United States)

    Whitehead, P. G.; Caesar, J.; Crossman, J.; Barbour, E.; Ledesma, J.; Futter, M. N.

    2015-12-01

    A semi-distributed flow and water quality model (INCA- Integrated Catchments Model) has been set up for the whole of the Ganges- Brahmaputra- Meghna (GBM) River system in India and Bangladesh. These massive rivers transport large fluxes of water and nutrients into the Bay of Bengal via the GBM Delta system in Bangladesh. Future climate change will impact these fluxes with changing rainfall, temperature, evapotranspiration and soil moisture deficits being altered in the catchment systems. In this study the INCA model has been used to assess potential impacts of climate change using the UK Met Office Hadley Centre GCM model linked to a regionally coupled model of South East Asia, covering India and Bangladesh. The Hadley Centre model has been pururbed by varying the parameters in the model to generate 17 realisations of future climates. Some of these reflect expected change but others capture the more extreme potential behaviour of future climate conditions. The 17 realisations have been used to drive the INCA Flow and Nitrogen model inorder to generate downstream times series of hydrology and nitrate- nitrogen. The variability of the climates on these fluxes are investigated and and their likley impact on the Bay of Begal Delta considered. Results indicate a slight shift in the monsoon season with increased wet season flows and increased temperatures which alter nutrient fluxes. Societal Importance to Stakeholders The GBM Delta supports one of the most densely populated regions of people living in poverty, who rely on ecosystem services provided by the Delta for survival. These ecosystem services are dependent upon fluxes of water and nutrients. Freshwater for urban, agriculture, and aquaculture requirements are essential to livelihoods. Nutrient loads stimulate estuarine ecosystems, supporting fishing stocks, which contribute significantly the economy of Bangladesh. Thus the societal importance of upstream climate driven change change in Bangladesh are very

  12. Evolution of Indian Ocean biases in the summer monsoon season hindcasts from the Met Office Global Seasonal Forecasting System GloSea5

    Science.gov (United States)

    Chevuturi, A.; Turner, A. G.; Woolnough, S. J.

    2016-12-01

    In this study we investigate the development of biases in the Indian Ocean region in summer hindcasts of the UK Met Office coupled initialised global seasonal forecasting system, GloSea5-GC2. Previous work has demonstrated the rapid evolution of strong monsoon circulation biases over India from seasonal forecasts initialised in early May, together with coupled strong easterly wind biases on the equator. We analyse a set of three springtime start dates for the 20-year hindcast period (1992-2011) and fifteen total ensemble members for each year. We use comparisons with a variety of observations to test the rate of evolving mean-state biases in the Arabian Sea, over India, and over the equatorial Indian Ocean. Biases are all shown to develop rapidly, particularly for the circulation bias over India that is connected to convection. These circulation biases later reach the surface and lead to responses in Arabian Sea SST in accordance with coastal and Ekman upwelling processes. We also assess the evolution of radiation and turbulent heat fluxes at the surface. Meanwhile at the equator, easterly biases in surface winds are shown to develop rapidly, consistent with an SST pattern that is consistent with positive-Indian Ocean dipole mean state conditions (warm western equatorial Indian Ocean, cold east). This bias develops consistent with coupled ocean-atmosphere exchanges and Bjerknes feedback. We hypothesize that lower tropospheric easterly wind biases developing in the equatorial region originate from the surface, and also that signals of the cold bias in the eastern equatorial Indian Ocean propagate to the Bay of Bengal via coastal Kelvin waves. Earlier work has shown the utility of wind-stress corrections in the Indian Ocean for correcting the easterly winds bias there and ultimately improving the evolution of the Indian Ocean Dipole. We identify and test this wind-stress correction technique in case study years from the hindcast period to see their impact on seasonal

  13. Technical Note: Description and assessment of a nudged version of the new dynamics Unified Model

    Directory of Open Access Journals (Sweden)

    O. Morgenstern

    2008-03-01

    Full Text Available We present a "nudged" version of the Met Office general circulation model, the Unified Model. We constrain this global climate model using ERA-40 re-analysis data with the aim of reproducing the observed "weather" over a year from September 1999. Quantitative assessments are made of its performance, focusing on dynamical aspects of nudging and demonstrating that the "weather" is well simulated.

  14. Unifying Abstractions

    DEFF Research Database (Denmark)

    Torgersen, Mads

    This thesis presents the RUNE language, a semantic construction of related and tightly coupled programming constructs presented in the shape of a programming language. The major contribution is the succesfull design of a highly unified and general programming model, capable of expressing some of ...... a unified name declaration mechanism. The resulting expressiveness allows for argument covariance, dependent types and module types, plus a solution to the so-called expression problem of two way extensibility in object-oriented languages....... of the most complex type relations put forth in type systems research, without compromising such fundamental qualities as conceptuality, modularity and static typing. While many new constructs and unifications are put forth  to substantiate their conceptual validity, type rules are given to support...

  15. Why unify

    International Nuclear Information System (INIS)

    Georgi, H.

    1980-01-01

    Unified gauge theories such as SU(5) of particle interactions are built on the colour SU(3) and SU(2) x U(1) gauge theories which apparently describe strong and weak and electromagnetic interactions at distances as small as 10 -16 cm. In this article the classical reasons for going beyond SU(3)xSU(2)xU(1) to a fully unified theory such as SU(5) are reviewed, and a new reason formulated. A class of imaginary worlds similar to our own is considered and it is shown that unification is possible only in ours. This suggests that the low-energy interactions are unique in that they are constructed to make unification possible. (author)

  16. Geoengineering by stratospheric SO2 injection: results from the Met Office HadGEM2 climate model and comparison with the Goddard Institute for Space Studies ModelE

    Directory of Open Access Journals (Sweden)

    B. Kravitz

    2010-07-01

    Full Text Available We examine the response of the Met Office Hadley Centre's HadGEM2-AO climate model to simulated geoengineering by continuous injection of SO2 into the lower stratosphere, and compare the results with those from the Goddard Institute for Space Studies ModelE. Despite the differences between the models, we find a broadly similar geographic distribution of the response to geoengineering in both models in terms of near-surface air temperature and mean June–August precipitation. The simulations also suggest that significant changes in regional climate would be experienced even if geoengineering was successful in maintaining global-mean temperature near current values, and both models indicate rapid warming if geoengineering is not sustained.

  17. Unifying Physics

    Science.gov (United States)

    Goradia, Shantilal

    2013-04-01

    Century old GR fails to unify quantum physics, nuclear force or distinguish between the mass of living bodies from inert mass. Probabilistic gravity [1] explains strong coupling (nuclear force). The natural log of the age of the universe, 10E60 in Planck times, equaling 137 (1/Alpha) extends physics to deeper science, if we stand on the shoulders of giants like Feynman and Gamow. Implications of [1] are that it is not the earth, but M and S numbers of the particles of the earth are remotely interacting with corresponding numbers of the particles of the moon and the sun respectively, neglecting other heavenly bodies in this short draft. This new physics is likely to enable creative scientific minds to throw light on a theoretical basis for an otherwise arbitrary cosmological constant, uniformity of microwave background, further vindication of Boltzmann, quantum informatics, Einstein’s later publicized views and more, eliminating the need to spend money for implicitly nonexistent quantum gravity and graviton.[4pt] [1] Journal of Physical Science and Applications 2 (7) (2012) 265-268.

  18. Evaluation of the UK Met Office's HadGEM3-RA and HadRM3P regional climate models within South America-CORDEX simulations: ENSO related interannual precipitation variability

    Science.gov (United States)

    Bozkurt, D.; Rojas, M.

    2014-12-01

    This study aims to investigate and compare the ability of the UK Met Office's HadGEM3-RA and HadRM3P regional climate models (RCMs) to simulate mean and interannual variability of precipitation over South America with a special focus on Chile. The HadGEM3-RA is a regional version of the newly developed HadGEM3 global model and the HadRM3P is based on the earlier HadCM3 global model. The RCMs simulations were carried out at 0.44o x 0.44o degree resolution over South America-CORDEX domain for the period 1989-2008. The initial and boundary conditions were provided by ERA-Interim Reanalysis data available at 6-h intervals with a resolution of 1.5o x 1.5o in the horizontal and 37 pressure levels. We compare the results against a number of observational datasets, including gridded dataset of CRU, UDEL, TRMM and GPCP. Moreover, available station data is derived from Direccion General de Aguas (DGA) mainly for Central Chile, which is the heartland of Chile with the highest population and important economic activities. The analysis is mainly focused on evaluating the abilities of the RCMs in simulating spatial pattern and ENSO related precipitation variability in different subregions of South America-CORDEX domain. In general, both RCMs have a good skill in reproducing spatial pattern and annual cycle of observed precipitation in climatically different subregions. However, both RCMs tend to underestimate precipitation in the Amazon Basin, which is more pronounced in the HadRM3P simulations. On the contrary, the RCMs tend to overestimate the precipitation over the Andes and southern Chile. The overestimation could be related to the physical core of the RCMs, but the discrepancies could also arise due to insufficient station network, especially in the mountainous areas, potentially yielding smaller precipitation quantities in the observed data than the true ones. In terms of interannual variability, the models capture ENSO related wet and dry interannual precipitation

  19. Unified Internet Messaging

    OpenAIRE

    Healy, Paul; Barber, Declan

    2015-01-01

    As telephony services, mobile services and internet services continue to converge, the prospect of providing Unified Messaging and even Unified Communications becomes increasingly achievable. This paper discusses the growing importance of IP-based networks to Unified Messaging developments and examines some of the key services and protocols that are likely to make Unified Messaging more widely available. In this initial paper, we limit ourselves initially to the unification of text-based mess...

  20. Sereniteit met een dip

    NARCIS (Netherlands)

    dr Ed de Jonge

    2015-01-01

    Boekbespreking van Serendipiteit. De ongezochte vondst. Het boek opent met een verzameling van citaten die direct of indirect met het onderwerp samenhangen. Daarna volgt een kort voorwoord van Hans Clevers, de toenmalige president van de KNAW, die een lans breekt voor serendipiteit in de biologie.

  1. Ervaringen met beeldverwerking.

    NARCIS (Netherlands)

    Meuleman, J.

    1989-01-01

    Verslag van een werkbezoek aan het Franse instituut Cemagref, met nadruk op beeldverwerking. Toepassingen van beeldverwerking zijn onder andere: een plukrobot voor appels; het detecteren van oppervlaktebeschadigingen bij appels; het detecteren van breuk in eieren; remote sensing

  2. Nisine geholpen met hordentechnologie

    NARCIS (Netherlands)

    Jong, de L.S.

    2001-01-01

    Een combinatie van nisine met carvacrol, thymol of carvon leidde tot een synergistische reductie van het aantal levensvatbare cellen van Listeria monocytogenes en Bacillus cereus. Verslag van een promotieonderzoek

  3. Autorijden met ADHD

    NARCIS (Netherlands)

    Fuermaier, Anselm B.M.; Tucha, Lara; de Vries, Stefanie M.; Koerts, Janneke; de Waard, Dick; Brookhuis, Karel; Tucha, Oliver

    Volwassenen met attention deficit hyperactivity disorder (ADHD) hebben uiteenlopende cognitieve beperkingen, die een aanzienlijke invloed kunnen hebben op verschillende aspecten van het dagelijks leven. Een van deze aspecten is het besturen van een auto. Autorijden is een belangrijke activiteit in

  4. When Historiography Met Epistemology

    Directory of Open Access Journals (Sweden)

    Jean-François Stoffel

    2017-06-01

    Full Text Available Review of Bordoni, Stefano. When historiography met epistemology: Sophisticated histories and philosophies of science in French-speaking countries in the second half of the nineteenth century. Reviewed by Jean-François Stoffel.

  5. Jeugd met beperkingen

    NARCIS (Netherlands)

    Sjoerd Kooiker

    2006-01-01

    Voor kinderen en jongeren met een lichamelijke of verstandelijke beperking is 'gewoon meedoen' in de samenleving geen vanzelfsprekendheid.  Zij ervaren vaak meer obstakels bij het naar school gaan, het vinden van een baan en in hun vrijetijdsbesteding dan andere kinderen en jongeren. Ook

  6. Studeren met Hans Rosenberg

    NARCIS (Netherlands)

    Rutten, R.J.

    2001-01-01

    Hoe was het om in de jaren zestig te studeren? Laat ik een terugblik ophangen aan een studiemakker, Hans Rosenberg. We vormden samen de sterrekundejaar- gang 1961. Hans studeerde af in 1966 met hoofdvak wiskunde, promoveerde op radiostralingsprocessen in de zonnecorona in 1973, verliet de

  7. SPSS met syntax

    NARCIS (Netherlands)

    Grotenhuis, H.F. te; Visscher, C.A.M.

    2007-01-01

    Dit boekje wijkt af van de gebruikelijke statistiekboeken omdat het sec gaat over het bekende statistische computerprogramma SPSS, en dan alleen nog de oorspronkelijke variant waarin wordt gewerkt met syntax (intypen commando's -zoals bij DOS) i.p.v. de later ontwikkelde 'Windows-schil' (aanklikken

  8. Pastoors naar de PFA: nieuwe impuls voor samenwerking met de wetenschap (interview met Martin Pastoors)

    NARCIS (Netherlands)

    Pastoors, M.A.

    2014-01-01

    De Pelagic Freezer-trawler Association (PFA) heeft visserijonderzoeler Martin Pastoors aangenomen als 'Chief Science Officer'. De afgelopen tien jaar is de PFA zich steeds meer bezig gaan houden met wetenschappelijk onderzoek. Bijvoorbeeld door het ontwikkelen van nieuwe manieren om data te

  9. Grand unified theories

    International Nuclear Information System (INIS)

    Rosner, J.L.

    1987-01-01

    This paper reports on a pedagogical introduction that attempts to unify the strong and electroweak interactions. Unifying groups discussed include SU(5), SO(10), and E 6 . Particular attention is paid to the questions of whether the low-energy gauge group (that accessible at accelerator experiments in the foreseeable future) extends beyond SU(3) x SU(2) L x U(1). Low-energy studies of neutral-current effects, direct production of gauge bosons, and new fermions all can shed light on this question. Brief remarks are made concerning the role of monopoles, cosmic strings, baryogenesis, supersymmetry, and higher dimensions in this program

  10. Cromatografia unificada Unified chromatography

    Directory of Open Access Journals (Sweden)

    Carin von Mühlen

    2004-10-01

    Full Text Available The scope of this study encompasses an overview of the principles of unified chromatography as well as the principles of chromatographic techniques as applied to unified systems, which include gas chromatography, liquid chromatography, supercritical fluid chromatography, high temperature and high pressure liquid chromatography, micro-liquid chromatography, enhanced fluidity chromatography, and solvating gas chromatography. Theoretical considerations and individual instrumental parameters such as mobile phase, sample introduction system, columns, and detection system are also discussed. Future applications of this separation approach are discussed.

  11. Met kerse op met -konstruksies 1 : 'n Verwysingspuntperspektief ...

    African Journals Online (AJOL)

    Met kerse op met-konstruksies1: 'n Verwysingspuntperspektief. Johanna Messerschmidt, Luna Bergh. Abstract. This article analyses the usage of the Afrikaans preposition met ('with'). The analysis is done within the framework of Cognitive Linguistics and more specifically within the model proposed by Langacker (1993) ...

  12. Unified electricity market

    International Nuclear Information System (INIS)

    Anon

    2011-01-01

    A unified European electricity market means a unification and harmonisation of functioning of the national electricity market into one European Market or into one entity. It gives an opportunity to Slovenske elektrarne to open room for their wider activity within Europe where common rules for cross-boarder trade and markets functioning will apply. (author)

  13. Unified field theory

    International Nuclear Information System (INIS)

    Prasad, R.

    1975-01-01

    Results of researches into Unified Field Theory over the past seven years are presented. The subject is dealt with in chapters entitled: the choice of affine connection, algebraic properties of the vector fields, field laws obtained from the affine connection based on the path integral method, application to quantum theory and cosmology, interpretation of physical theory in terms of geometry. (U.K.)

  14. Finite unified models

    Energy Technology Data Exchange (ETDEWEB)

    Kapetanakis, D. (Technische Univ. Muenchen, Garching (Germany). Physik Dept.); Mondragon, M. (Technische Univ. Muenchen, Garching (Germany). Physik Dept.); Zoupanos, G. (National Technical Univ., Athens (Greece). Physics Dept.)

    1993-09-01

    We present phenomenologically viable SU(5) unified models which are finite to all orders before the spontaneous symmetry breaking. In the case of two models with three families the top quark mass is predicted to be 178.8 GeV. (orig.)

  15. Finite unified models

    International Nuclear Information System (INIS)

    Kapetanakis, D.; Mondragon, M.; Zoupanos, G.

    1993-01-01

    We present phenomenologically viable SU(5) unified models which are finite to all orders before the spontaneous symmetry breaking. In the case of two models with three families the top quark mass is predicted to be 178.8 GeV. (orig.)

  16. The Unified Theory of Physics

    OpenAIRE

    Chung, Ding-Yu

    2002-01-01

    The unified theory of physics unifies various phenomena in our observable universe and other universes. The unified theory is based on the zero-energy universe and the space-object structures. Different universes in different developmental stages are the different expressions of the space-object structures. The unified theory is divided into five parts: the space-object structures, cosmology, the periodic table of elementary particles, the galaxy formation, and the extreme force field. The sp...

  17. Grand unified theories

    International Nuclear Information System (INIS)

    Langacker, P.

    1981-01-01

    In this talk I discuss the present status of these theories and of their observational and experimental implications. In section II, I briefly review the standard SU 3 sup(c) x SU 2 x U 1 model of the strong and electroweak interactions. Although phenomenologically successful, the standard model leaves many questions unanswered. Some of these questions are addressed by grand unified theories, which are defined and discussed in Section III. The Georgi-Glashow SU 5 model is described, as are theories based on larger groups such as SO 10 , E 6 , or SO 16 . It is emphasized that there are many possible grand unified theories and that it is an experimental problem not only to test the basic ideas but to discriminate between models. (orig./HSI)

  18. A unified universe

    DEFF Research Database (Denmark)

    Codello, Alessandro; Jain, Rajeev Kumar

    2018-01-01

    We present a unified evolution of the universe from very early times until the present epoch by including both the leading local correction R2 and the leading non-local term R1□2R to the classical gravitational action. We find that the inflationary phase driven by R2 term gracefully exits...... in a transitory regime characterized by coherent oscillations of the Hubble parameter. The universe then naturally enters into a radiation dominated epoch followed by a matter dominated era. At sufficiently late times after radiation–matter equality, the non-local term starts to dominate inducing an accelerated...... expansion of the universe at the present epoch. We further exhibit the fact that both the leading local and non-local terms can be obtained within the covariant effective field theory of gravity. This scenario thus provides a unified picture of inflation and dark energy in a single framework by means...

  19. Operation Unified Protector

    DEFF Research Database (Denmark)

    Buhl, Kenneth Øhlenschlæger

    2012-01-01

    Formålet med denne artikel er at se nærmere på erfaringerne fra den maritime kampagne under den militære indsats i konflikten i Libyen i 2011, som i NATO regi blev kendt som Operation Unified Protector (OUP). Dækningen i de danske medier fokuserede primært på luftkampagnen, hvilket må tilskrives,...

  20. Unified Engineering Software System

    Science.gov (United States)

    Purves, L. R.; Gordon, S.; Peltzman, A.; Dube, M.

    1989-01-01

    Collection of computer programs performs diverse functions in prototype engineering. NEXUS, NASA Engineering Extendible Unified Software system, is research set of computer programs designed to support full sequence of activities encountered in NASA engineering projects. Sequence spans preliminary design, design analysis, detailed design, manufacturing, assembly, and testing. Primarily addresses process of prototype engineering, task of getting single or small number of copies of product to work. Written in FORTRAN 77 and PROLOG.

  1. Rational Unified Process

    OpenAIRE

    Kopal, Nils

    2016-01-01

    In this German seminar paper, which was written in the year 2011 at the University of Duisburg for a Bachelor Colloquium in Applied computer science, we show a brief overview of the Rational Unified Process (RUP). Thus, interested students or generally interested people in software development gain a first impression of RUP. The paper includes a survey and overview of the underlying process structure, the phases of the process, its workflows, and describes the always by the RUP developers pos...

  2. Gezondheidsrisico's in verband met het werken met Pentachloorfenol : een onderzoek

    NARCIS (Netherlands)

    Geuskens, R.B.M.; Nossent, S.M.; Koëter, H.B.W.M.; Dreef-van der Meulen, H.C.; Stijkel, A.; Zielhuis, R.l.

    1989-01-01

    De gezondheidsrisico's i.v.m. het werken met pentachloorfenol (PCP) wordt geevalueerd. Het gebruik van PCP in Nederlandse arbeidssituaties neemt sterk af en is beperkt tot de formulering van emeltenkorrels en de, met name preventieve, houtverduurzaming. De totale risicopopulatie is niet omvangrijk

  3. Microbewerking met behulp van lasers

    NARCIS (Netherlands)

    Ezendam, M.M.M.

    1994-01-01

    Het bewerken van materialen met behulp van lasers staat momenteel enorm in de belangstelling, en terecht. De ontwikkeling van bestaande en nieuwe typen lasers staat alles behalve stil. Ontwikkelingen bevinden zich met name in het gebied van hogere vermogens, betere bundelkwaliteit en hogere

  4. Unified Symmetry of Hamilton Systems

    International Nuclear Information System (INIS)

    Xu Xuejun; Qin Maochang; Mei Fengxiang

    2005-01-01

    The definition and the criterion of a unified symmetry for a Hamilton system are presented. The sufficient condition under which the Noether symmetry is a unified symmetry for the system is given. A new conserved quantity, as well as the Noether conserved quantity and the Hojman conserved quantity, deduced from the unified symmetry, is obtained. An example is finally given to illustrate the application of the results.

  5. Unified Bohm criterion

    Energy Technology Data Exchange (ETDEWEB)

    Kos, L. [LECAD Laboratory, Faculty of Mechanical Engineering, University of Ljubljana, SI-1000 Ljubljana (Slovenia); Tskhakaya, D. D.; Jelić, N. [Institute for Theoretical Physics, Fusion@ÖAW, University of Innsbruck, A-6020 Innsbruck (Austria)

    2015-09-15

    Recent decades have seen research into the conditions necessary for the formation of the monotonic potential shape in the sheath, appearing at the plasma boundaries like walls, in fluid, and kinetic approximations separately. Although either of these approaches yields a formulation commonly known as the much-acclaimed Bohm criterion (BC), the respective results involve essentially different physical quantities that describe the ion gas behavior. In the fluid approach, such a quantity is clearly identified as the ion directional velocity. In the kinetic approach, the ion behavior is formulated via a quantity (the squared inverse velocity averaged by the ion distribution function) without any clear physical significance, which is, moreover, impractical. In the present paper, we try to explain this difference by deriving a condition called here the Unified Bohm Criterion, which combines an advanced fluid model with an upgraded explicit kinetic formula in a new form of the BC. By introducing a generalized polytropic coefficient function, the unified BC can be interpreted in a form that holds, irrespective of whether the ions are described kinetically or in the fluid approximation.

  6. Beyond the Unified Model

    Science.gov (United States)

    Frauendorf, S.

    2018-04-01

    The key elements of the Unified Model are reviewed. The microscopic derivation of the Bohr Hamiltonian by means of adiabatic time-dependent mean field theory is presented. By checking against experimental data the limitations of the Unified Model are delineated. The description of the strong coupling between the rotational and intrinsic degrees of freedom in framework of the rotating mean field is presented from a conceptual point of view. The classification of rotational bands as configurations of rotating quasiparticles is introduced. The occurrence of uniform rotation about an axis that differs from the principle axes of the nuclear density distribution is discussed. The physics behind this tilted-axis rotation, unknown in molecular physics, is explained on a basic level. The new symmetries of the rotating mean field that arise from the various orientations of the angular momentum vector with respect to the triaxial nuclear density distribution and their manifestation by the level sequence of rotational bands are discussed. Resulting phenomena, as transverse wobbling, rotational chirality, magnetic rotation and band termination are discussed. Using the concept of spontaneous symmetry breaking the microscopic underpinning of the rotational degrees is refined.

  7. Gezondheidsrisico's in verband met het werken met Polychloorbifenylen : een onderzoek

    NARCIS (Netherlands)

    Geuskens, R.B.M.; Nossent, S.M.; Koëter, H.B.W.M.; Dreef-van der Meulen, H.C.; Stijkel, A.; Zielhuis, R.L.

    1989-01-01

    Met behulp van gegevens verkregen uit een werkplekinventarisatie naar gegevens over produktie/gebruik, risicopopulatie en (mogelijke) blootstelling aan polychloorbifenylen (PCB's), en een literatuurstudie naar mogelijke schadelijke eigenschappen van PCB's op het reproductiesysteem en/of nageslacht

  8. Department of Education Revives Civil Rights Office

    Science.gov (United States)

    Finkel, Ed

    2010-01-01

    This article reports on the mission of the Office for Civil Rights in the U.S. Department of Education to ensure equal access to education through compliance reviews. The Office hopes to use these reviews to provide technical assistance to help districts improve their performance. In late March, the Los Angeles Unified School District became the…

  9. Direction: unified theory of interactions

    International Nuclear Information System (INIS)

    Valko, P.

    1987-01-01

    Briefly characterized are the individual theories, namely, the general relativity theory, the Kaluza-Klein theory, the Weyl theory, the unified theory of electromagnetic and weak interactions, the supergravity theory, and the superstring theory. The history is recalled of efforts aimed at creating a unified theory of interactions, and future prospects are outlined. (M.D.). 2 figs

  10. Grand unified theories. Pt. 2

    International Nuclear Information System (INIS)

    Ellis, J.

    1982-01-01

    The author gives an introduction to the construction of grand unified theories on the base of the SU(3)xSU(2)xU(1) model of the strong, weak, and electromagnetic interactions. Especially he discusses the proton decay, neutrino masses and oscillations, and cosmological implications in connection with grand unified theories. (orig./HSI)

  11. 41 CFR 109-25.104 - Acquisition of office furniture and office machines.

    Science.gov (United States)

    2010-07-01

    ... furniture and office machines. 109-25.104 Section 109-25.104 Public Contracts and Property Management... furniture and office machines. DOE offices and designated contractors shall make the determination as to whether requirements can be met through the utilization of DOE owned furniture and office machines. ...

  12. Seven Deadliest Unified Communications Attacks

    CERN Document Server

    York, Dan

    2010-01-01

    Do you need to keep up with the latest hacks, attacks, and exploits effecting Unified Communications technology? Then you need Seven Deadliest Unified Communication Attacks. This book pinpoints the most dangerous hacks and exploits specific to Unified Communications, laying out the anatomy of these attacks including how to make your system more secure. You will discover the best ways to defend against these vicious hacks with step-by-step instruction and learn techniques to make your computer and network impenetrable. Attacks featured in this book include: UC Ecosystem Attacks Insecure Endpo

  13. 76 FR 39991 - Introduction to the Unified Agenda of Federal Regulatory and Deregulatory Actions

    Science.gov (United States)

    2011-07-07

    .... Abbreviations VI. How Can Users Get Copies of the Plan and the Agenda? Agency Agendas Cabinet Departments...://reginfo.gov . The online Unified Agenda offers flexible search tools and will soon offer access to the... Government Ethics Office of Management and Budget Office of Personnel Management Peace Corps Pension Benefit...

  14. UPQC (Unified power Quality Conditioner)

    Indian Academy of Sciences (India)

    First page Back Continue Last page Graphics. UPQC (Unified power Quality Conditioner). Hybrid of Shunt and Series compensator. Compensate both Current Quality and Voltage Quality. Costlier Solution as it involves two set of Inverters.

  15. Model of unified gauge fields

    International Nuclear Information System (INIS)

    Leite Lopes, J.

    1998-04-01

    In this work, we discuss the physical ideas which represents the basis for the unified gauge field model. Despite of the difficulties that we presently have for embodying in a natural manner muons and hadrons in that model, we have the feeling that we are on the way which seems to lead to the construction of a theory in which the Maxwell electromagnetic field and the Fermi weak interaction field are manifestations of a unique subjacent physical entity - the unified gauge fields. (author)

  16. Short-Range Prediction of Monsoon Precipitation by NCMRWF Regional Unified Model with Explicit Convection

    Science.gov (United States)

    Mamgain, Ashu; Rajagopal, E. N.; Mitra, A. K.; Webster, S.

    2018-03-01

    There are increasing efforts towards the prediction of high-impact weather systems and understanding of related dynamical and physical processes. High-resolution numerical model simulations can be used directly to model the impact at fine-scale details. Improvement in forecast accuracy can help in disaster management planning and execution. National Centre for Medium Range Weather Forecasting (NCMRWF) has implemented high-resolution regional unified modeling system with explicit convection embedded within coarser resolution global model with parameterized convection. The models configurations are based on UK Met Office unified seamless modeling system. Recent land use/land cover data (2012-2013) obtained from Indian Space Research Organisation (ISRO) are also used in model simulations. Results based on short-range forecast of both the global and regional models over India for a month indicate that convection-permitting simulations by the high-resolution regional model is able to reduce the dry bias over southern parts of West Coast and monsoon trough zone with more intense rainfall mainly towards northern parts of monsoon trough zone. Regional model with explicit convection has significantly improved the phase of the diurnal cycle of rainfall as compared to the global model. Results from two monsoon depression cases during study period show substantial improvement in details of rainfall pattern. Many categories in rainfall defined for operational forecast purposes by Indian forecasters are also well represented in case of convection-permitting high-resolution simulations. For the statistics of number of days within a range of rain categories between `No-Rain' and `Heavy Rain', the regional model is outperforming the global model in all the ranges. In the very heavy and extremely heavy categories, the regional simulations show overestimation of rainfall days. Global model with parameterized convection have tendency to overestimate the light rainfall days and

  17. Wartime Roles and Capabilities for the Unified Logistic Staffs

    Science.gov (United States)

    1989-02-01

    standard Army ammunition system SAPO Subarea Petroleum Office SCP service control point (fuels) SHAPE Supreme Headquarters, Allied Powers Europe SIDATH... SAPOs ). Communication exists between the operations and logistic staffs within the unified, component, Service, and JS levels. But between...daily. The JPOs/ SAPOs receive the short-term requirements and consoli- date them for resupply by submitting slates (how much, when, and where needed

  18. La metáfora

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2007-01-01

    2002 y principios de 2003, anteriores a la proclamación de las Juntas de Buen Gobierno. Nuestro objetivo es comprobar cómo las metáforas crean nuevas significaciones, que intentan deshacer una lógica comúnmente asumida, y promover otros modos de comprender la acción y la realidad político-social. Este...

  19. 34 CFR 692.101 - What requirements must be met by a State partnership?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What requirements must be met by a State partnership...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION LEVERAGING EDUCATIONAL ASSISTANCE PARTNERSHIP... What requirements must be met by a State partnership? (a) State. A State that is receiving an allotment...

  20. Evaluation of Temperature and Humidity Profiles of Unified Model and ECMWF Analyses Using GRUAN Radiosonde Observations

    Directory of Open Access Journals (Sweden)

    Young-Chan Noh

    2016-07-01

    Full Text Available Temperature and water vapor profiles from the Korea Meteorological Administration (KMA and the United Kingdom Met Office (UKMO Unified Model (UM data assimilation systems and from reanalysis fields from the European Centre for Medium-Range Weather Forecasts (ECMWF were assessed using collocated radiosonde observations from the Global Climate Observing System (GCOS Reference Upper-Air Network (GRUAN for January–December 2012. The motivation was to examine the overall performance of data assimilation outputs. The difference statistics of the collocated model outputs versus the radiosonde observations indicated a good agreement for the temperature, amongst datasets, while less agreement was found for the relative humidity. A comparison of the UM outputs from the UKMO and KMA revealed that they are similar to each other. The introduction of the new version of UM into the KMA in May 2012 resulted in an improved analysis performance, particularly for the moisture field. On the other hand, ECMWF reanalysis data showed slightly reduced performance for relative humidity compared with the UM, with a significant humid bias in the upper troposphere. ECMWF reanalysis temperature fields showed nearly the same performance as the two UM analyses. The root mean square differences (RMSDs of the relative humidity for the three models were larger for more humid conditions, suggesting that humidity forecasts are less reliable under these conditions.

  1. Designers' unified cost model

    Science.gov (United States)

    Freeman, W.; Ilcewicz, L.; Swanson, G.; Gutowski, T.

    1992-01-01

    The Structures Technology Program Office (STPO) at NASA LaRC has initiated development of a conceptual and preliminary designers' cost prediction model. The model will provide a technically sound method for evaluating the relative cost of different composite structural designs, fabrication processes, and assembly methods that can be compared to equivalent metallic parts or assemblies. The feasibility of developing cost prediction software in a modular form for interfacing with state-of-the-art preliminary design tools and computer aided design programs is being evaluated. The goal of this task is to establish theoretical cost functions that relate geometric design features to summed material cost and labor content in terms of process mechanics and physics. The output of the designers' present analytical tools will be input for the designers' cost prediction model to provide the designer with a database and deterministic cost methodology that allows one to trade and synthesize designs with both cost and weight as objective functions for optimization. This paper presents the team members, approach, goals, plans, and progress to date for development of COSTADE (Cost Optimization Software for Transport Aircraft Design Evaluation).

  2. Experimental status of unified theories

    International Nuclear Information System (INIS)

    Bilen'kij, S.M.

    1979-01-01

    A standard SU(2)xU(1) theory is discussed. It is based on an assumption that the left components of fields form doublets, and the rignt ones - singlets. From the weak interaction lagrangian an expression is obtained for the effective hamiltonian describing neutrino-lepton processes. The results of discussing the experimental status of the unified theories of weak and electromagnetic interactions are in agreement with the simplest version of the unified theories - the Weinberg-Salam theory. It has been noted that the accuracy of the experiments (not exceeding 20%) is insufficient and no information is available on diagonal terms of the hamiltonian

  3. The Simplest Unified Growth Theory

    DEFF Research Database (Denmark)

    Strulik, Holger; Weisdorf, Jacob Louis

    This paper provides a unified growth theory, i.e. a model that explains the very long-run economic and demographic development path of industrialized economies, stretching from the pre-industrial era to present-day and beyond. Making strict use of Malthus' (1798) so-called preventive check...... hypothesis - that fertility rates vary inversely with the price of food - the current study offers a new and straightforward explanation for the demographic transition and the break with the Malthusian era. The current framework lends support to existing unified growth theories and is well in tune...

  4. Toward a Unified Communication Theory.

    Science.gov (United States)

    McMillan, Saundra

    After discussing the nature of theory itself, the author explains her concept of the Unified Communication Theory, which rests on the assumption that there exists in all living structures a potential communication factor which is delimited by species and ontogeny. An organism develops "symbol fixation" at the level where its perceptual abilities…

  5. A model unified field equation

    International Nuclear Information System (INIS)

    Perring, J.K.; Skyrme, T.H.R.

    1994-01-01

    The classical solutions of a unified field theory in a two-dimensional space-time are considered. This system, a model of a interacting mesons and baryons, illustrates how the particle can be built from a wave-packet of mesons and how reciprocally the meson appears as a tightly bound combination of particle and antiparticle. (author). 6 refs

  6. Reactions of Met-Cars

    International Nuclear Information System (INIS)

    Castleman, A.W. Jr.; Guo, B.C.

    1993-01-01

    A new class of metal-carbon complexes, termed metallo-carbohedrenes (Met-Cars), have been discovered to form in a plasma reactor in which early transition metals are vaporized into a stream carrying small hydrocarbon molecules. The initial discovery involved the species Ti 8 c 12 + , while subsequent studies revealed the stability of the anion and, most importantly, the neutral species. Subsequent investigations show that similar molecules, predicted to have a pentagonal dodecahedral structure, can also be formed with vanadium, hafnium, and zirconium. In the case of the latter, more recent investigations have displaced an interesting growth pattern. In particular, pentagonal dodecahedrons with dangling carbon atoms can undergo further growth, adding at least a second and third cage. The latest results on the properties and reactivities of these new cage-like molecular clusters will be discussed

  7. Interannual rainfall variability over China in the MetUM GA6 and GC2 configurations

    Directory of Open Access Journals (Sweden)

    C. C. Stephan

    2018-05-01

    Full Text Available Six climate simulations of the Met Office Unified Model Global Atmosphere 6.0 and Global Coupled 2.0 configurations are evaluated against observations and reanalysis data for their ability to simulate the mean state and year-to-year variability of precipitation over China. To analyse the sensitivity to air–sea coupling and horizontal resolution, atmosphere-only and coupled integrations at atmospheric horizontal resolutions of N96, N216 and N512 (corresponding to ∼ 200, 90 and 40 km in the zonal direction at the equator, respectively are analysed. The mean and interannual variance of seasonal precipitation are too high in all simulations over China but improve with finer resolution and coupling. Empirical orthogonal teleconnection (EOT analysis is applied to simulated and observed precipitation to identify spatial patterns of temporally coherent interannual variability in seasonal precipitation. To connect these patterns to large-scale atmospheric and coupled air–sea processes, atmospheric and oceanic fields are regressed onto the corresponding seasonal mean time series. All simulations reproduce the observed leading pattern of interannual rainfall variability in winter, spring and autumn; the leading pattern in summer is present in all but one simulation. However, only in two simulations are the four leading patterns associated with the observed physical mechanisms. Coupled simulations capture more observed patterns of variability and associate more of them with the correct physical mechanism, compared to atmosphere-only simulations at the same resolution. However, finer resolution does not improve the fidelity of these patterns or their associated mechanisms. This shows that evaluating climate models by only geographical distribution of mean precipitation and its interannual variance is insufficient. The EOT analysis adds knowledge about coherent variability and associated mechanisms.

  8. Interannual rainfall variability over China in the MetUM GA6 and GC2 configurations

    Science.gov (United States)

    Stephan, Claudia Christine; Klingaman, Nicholas P.; Vidale, Pier Luigi; Turner, Andrew G.; Demory, Marie-Estelle; Guo, Liang

    2018-05-01

    Six climate simulations of the Met Office Unified Model Global Atmosphere 6.0 and Global Coupled 2.0 configurations are evaluated against observations and reanalysis data for their ability to simulate the mean state and year-to-year variability of precipitation over China. To analyse the sensitivity to air-sea coupling and horizontal resolution, atmosphere-only and coupled integrations at atmospheric horizontal resolutions of N96, N216 and N512 (corresponding to ˜ 200, 90 and 40 km in the zonal direction at the equator, respectively) are analysed. The mean and interannual variance of seasonal precipitation are too high in all simulations over China but improve with finer resolution and coupling. Empirical orthogonal teleconnection (EOT) analysis is applied to simulated and observed precipitation to identify spatial patterns of temporally coherent interannual variability in seasonal precipitation. To connect these patterns to large-scale atmospheric and coupled air-sea processes, atmospheric and oceanic fields are regressed onto the corresponding seasonal mean time series. All simulations reproduce the observed leading pattern of interannual rainfall variability in winter, spring and autumn; the leading pattern in summer is present in all but one simulation. However, only in two simulations are the four leading patterns associated with the observed physical mechanisms. Coupled simulations capture more observed patterns of variability and associate more of them with the correct physical mechanism, compared to atmosphere-only simulations at the same resolution. However, finer resolution does not improve the fidelity of these patterns or their associated mechanisms. This shows that evaluating climate models by only geographical distribution of mean precipitation and its interannual variance is insufficient. The EOT analysis adds knowledge about coherent variability and associated mechanisms.

  9. Met UM Upper-tropospheric summer jet teleconnections: A model assessment

    Science.gov (United States)

    Joao Carvalho, Maria; Rodriguez, Jose; Milton, Sean

    2017-04-01

    The upper tropospheric jet stream has been documented to act as a waveguide (Hoskins and Ambrizzi, 1993) and supporting quasi-stationary Rossby waves (Schubert et al. 2011). These have been associated with remote effects in surface level weather such as rainfall anomalies in the East Asian Summer Monsoon as well as extreme temperature events. The goal of this work was to analyse the intraseasonal to interannual upper level boreal summer jet variability and its coupling with low level atmospheric dynamics within the Met Office Unified Model using climate runs. Using the Wallace and Gutzler (1981) proposed approach to find teleconnection patterns on the 200 hPa level wind, lead-lag correlation and Empirical Orthogonal Function analysis on the upper-level jet and relating the results with surface weather variables as well as dynamical variables, it was found that the model presents too strong jet variability, particularly in the tropical region and. In addition, the model presents high teleconnectivity hotspots with higher importance in areas such as the Mediterranean and Caspian Sea which are important source areas for Rossby Waves. Further to this, the model was found to produce an area of teleconnectivity between the tropical Atlantic and western Africa which is not observed in the reanalysis but coexists with long lasting precipitation biases. As comparison for the model results, ERA-Interim circulation and wind data and the TRMM precipitation dataset were used. In order to assess the relative importance of relevant model parameters in the biases and process errors, work is currently underway using perturbed model parameter ensembles.

  10. Proef met duurzaam watergebruik in de bollenstreek

    NARCIS (Netherlands)

    Fliegenthart, F.; Dik, P.E.; Groenendijk, P.

    2009-01-01

    In 2007 begon in de Wieringermeer een praktijkproef met alternatieve waterbeheersystemen voor de bollenteelt. Met drie verschillende teeltsystemen wordt onderzoek verricht naar zo optimaal mogelijk gebruik van zoet water door recirculatie en hergebruik. Ook loopt onderzoek naar de emissie van

  11. Office Hysteroscopy

    OpenAIRE

    Hikmet Hassa; Basar Tekin; H. Mete Tanir; Bulent Cakmak

    2007-01-01

    Although hysteroscopy has evolved in recent years, its use in the office setting was not made practical until early 1980s with the introduction of small caliber hysteroscopes of less than 5- mm outer diameter.This innovation simplifies ambulatory uterine exploration and the office evaluation of patients with abnormal uterine bleeding. This article reviews current trends in office hysteroscopy and its areas of application in different forms of gynecological problems.

  12. Office Hysteroscopy

    Directory of Open Access Journals (Sweden)

    Hikmet Hassa

    2007-06-01

    Full Text Available Although hysteroscopy has evolved in recent years, its use in the office setting was not made practical until early 1980s with the introduction of small caliber hysteroscopes of less than 5- mm outer diameter.This innovation simplifies ambulatory uterine exploration and the office evaluation of patients with abnormal uterine bleeding. This article reviews current trends in office hysteroscopy and its areas of application in different forms of gynecological problems.

  13. Unified theory of effective interaction

    Energy Technology Data Exchange (ETDEWEB)

    Takayanagi, Kazuo, E-mail: k-takaya@sophia.ac.jp

    2016-09-15

    We present a unified description of effective interaction theories in both algebraic and graphic representations. In our previous work, we have presented the Rayleigh–Schrödinger and Bloch perturbation theories in a unified fashion by introducing the main frame expansion of the effective interaction. In this work, we start also from the main frame expansion, and present various nonperturbative theories in a coherent manner, which include generalizations of the Brandow, Brillouin–Wigner, and Bloch–Horowitz theories on the formal side, and the extended Krenciglowa–Kuo and the extended Lee–Suzuki methods on the practical side. We thus establish a coherent and comprehensive description of both perturbative and nonperturbative theories on the basis of the main frame expansion.

  14. Split supersymmetry in unified models

    International Nuclear Information System (INIS)

    Dutta, Bhaskar; Mimura, Yukihiro

    2005-01-01

    In the context of split supersymmetry, the gaugino mass spectrum seems to be very important to satisfy the dark matter content of the universe and the gauge coupling unification. In this Letter, we have considered various sources of gaugino masses in the context of unified models. We show that the gaugino mass spectrum varies in different unification pictures. In the context of SU(5), we have found that the bino/wino mass ratio can be close to one at the weak scale which is helpful to satisfy the WMAP data. The gluino/wino mass ratio is also different from the usual scenario of unified gaugino masses. The gaugino masses can be around one TeV and m SUSY is chosen so that the gluino mass does not create any cosmological problem. In the context of the Pati-Salam model, we show that the gluino mass can be made very heavy even after maintaining the unification of the gauge couplings

  15. Unified theory of the nucleus

    International Nuclear Information System (INIS)

    Wildermuth, K.; Tang, Y.C.

    1977-01-01

    The purpose of this monograph is to describe a microscopic nuclear theory which can be used to consider all low-energy nuclear phenomena from a unified viewpoint. In this theory, the Pauli principle is completely taken into account and translationally invariant wave functions are always employed. It can be utilized to study reactions initiated not only by nucleons but also by arbitrary composite particles

  16. Differences in MetS marker prevalence between black African and ...

    African Journals Online (AJOL)

    Multiple linear regression analysis, independent of covariates, showed that the albumin:creatinine ratio is explained only by glucose in Africans. Conclusion: African women, as a group, present with few MetS risk factors, and glucose is associated with renal function risk in Africans. Keywords: MetS, metabolic syndrome, ...

  17. Unified approach to dense matter

    International Nuclear Information System (INIS)

    Park, Byung-Yoon; Lee, Hee-Jung; Vento, Vicente; Kim, Joon-Il; Min, Dong-Pil; Rho, Mannque

    2005-01-01

    We apply the Skyrme model to dense hadronic matter, which provides a unified approach to high density, valid in the large N c limit. In our picture, dense hadronic matter is described by the classical soliton configuration with minimum energy for the given baryon number density. By incorporating the meson fluctuations on such ground state we obtain an effective Lagrangian for meson dynamics in a dense medium. Our starting point has been the Skyrme model defined in terms of pions, thereafter we have extended and improved the model by incorporating other degrees of freedom such as dilaton, kaons and vector mesons

  18. Einstein's theory of unified fields

    CERN Document Server

    Tonnelat, Marie Antoinette

    2014-01-01

    First published in1966, here is presented a comprehensive overview of one of the most elusive scientific speculations by the pre-eminent genius of the 20th century. The theory is viewed by some scientists with deep suspicion, by others with optimism, but all agree that it represents an extreme challenge. As the author herself affirms, this work is not intended to be a complete treatise or 'didactic exposition' of the theory of unified fields, but rather a tool for further study, both by students and professional physicists. Dealing with all the major areas of research whic

  19. Metsämaisema ulkoilijoiden kokemana

    OpenAIRE

    Vuohijoki, Jaana

    2010-01-01

    Työn aiheena oli tutkia, miten ulkoilijat kokevat metsämaiseman Tampereella. Tavoitteena oli selvittää ulkoilijoiden maisema-arvostuksia sekä suhtautumista metsänhoidon toimenpiteisiin. Tutkimus toteutettiin maastohaastatteluina Tampereella kolmella eri asuinalueella: Hallilassa, Leinolassa ja Tesomajärvellä. Otoskooksi muodostui kymmenen haastattelua aluetta kohti, mutta yhdeltä vastaajalta ei ehditty kysyä kaikkia kysymyksiä. Vastaajat olivat yleisesti ottaen tyytyväisiä alueiden metsän...

  20. 75 FR 77671 - Expansion of the Scope of NRTL Recognition of MET Laboratories, Inc.; Correction of the Scope of...

    Science.gov (United States)

    2010-12-13

    ... connection with this request, NRTL Program staff did not perform any on-site review of MET's recognized site... MET application are available for review by contacting the Docket Office, Occupational Safety and... and Marine Crafts UL 466 Electric Scales UL 561 Floor-Finishing Machines UL 1230 Amateur Movie Lights...

  1. Is neurofeedback effectief bij kinderen met ADHD?

    NARCIS (Netherlands)

    de Hen, M.H.; Geurts, H.M.

    2008-01-01

    Kan neurofeedback verantwoord ingezet worden bij de behandeling van kinderen met ADHD? Omdeze vraag te beantwoorden worden zeven recente onderzoeken naar de effectiviteit van neurofeedback bij kinderen met ADHD geanalyseerd. Ondanks dat de resultaten in eerste instantie lijken te suggereren dat

  2. A word from the DG: A unified Laboratory

    CERN Multimedia

    2008-01-01

    I complete my five years at the helm of CERN at the end of December and would like to take this opportunity to remind you of the route we have travelled during that time and to express my best wishes to you for the future. In addition to the vital priority of completing the LHC, I set myself two essential goals at the beginning of my term of office: to define a clear long-term strategy for CERN and to unify the Laboratory. These aims were essential in order to regain the confidence of the Member States, partly lost as a result of the crisis that occurred before I took up office, and to transform CERN into the key player in the European strategy for particle physics. We have succeeded in completing the LHC. Despite the incident in the machine, we were able to show very rapidly that the accelerator and its injection chain were well poised to deliver efficient operation and use. Our efforts to unify the Laboratory, to define the strateg...

  3. Word je met Donkey Konga een betere muzikant? : Muziek leren spelen met de spelcomputer

    NARCIS (Netherlands)

    Tom Langhorst

    2010-01-01

    Kan de spelcomputer behulpzaam zijn bij de ontwikkeling van het muzikale gevoel? Met die vraag in het achterhoofd bekijkt Tom Langhorst hier kritisch het Nintendo-spel Donkey Konga, waarin de speler mee kan drummen met bekende popsongs.

  4. Towards a Unified Programming Language

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    2000-01-01

    The goal of research in programming languages should be to develop languages that integrates the best of concepts and constructs from the various programming paradigms. We do not argue for a multi-paradigm language, where the programmer alternates between the different paradigms/styles. Instead, we...... find that the languages of the future should integrate the best available concepts and constructs in such a way that the programmer does not think of multiple paradigms when using a given language. In this paper, we describe to what extent the BETA language has been successful in obtaining a unified...... style and where more research is needed. In addition to traditional paradigms such as object-oriented-, imperative-functional- and logic programming, we also discuss concurrent programming and prototype-based programming. We discuss language features such as the BETA pattern construct, virtual...

  5. A unified plant information network

    International Nuclear Information System (INIS)

    Niederauer, G.F.

    1986-01-01

    Technology is bringing power plants fully into the age of computerization. Microcomputers, data base managers, networking, and friendly, expert software are principal technology factors. Monitoring will improve, and the number and power of computers is increasing. The huge information flow will cause computers to be integrated into a communication network. The total plant operating triangle includes process, engineering, and management systems. The total network will integrate all of these into a Total Unified Plant Information Network (TUPIN). Software will take the type of information beyond monitored data. Analysis will improve through direct access to logical, physical, and procedural models by end users. Information management will improve through widespread use of hierarchical, relational, and expert data base managers. Expert systems will aid in diagnostics and interpretation. The goal is to automate plant operations to enhance safety and performance and to reduce cost by making both the plants and the personnel more expert

  6. Cosmology and unified gauge theory

    Science.gov (United States)

    Oraifeartaigh, L.

    1981-09-01

    Theoretical points in common between cosmology and unified gauge theory (UGT) are reviewed, with attention given to areas of one which have proven useful for the other. The underlying principles for both theoretical frameworks are described, noting the differences in scale, i.e., 10 to the 25th cm in cosmology and 10 to the -15th cm for UGT. Cosmology has produced bounds on the number of existing neutrino species, and also on the mass of neutrinos, two factors of interest in particle physics. Electrons, protons, and neutrinos, having been spawned from the same massive leptons, each composed of three quarks, have been predicted to be present in equal numbers in the Universe by UGT, in line with necessities of cosmology. The Grand UGT also suggests specific time scales for proton decay, thus accounting for the observed baryon assymmetry.

  7. Unifying physical concepts of reality

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, T.L.

    1983-08-01

    Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large and the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences.

  8. Phenomenology of unified gauge theories

    International Nuclear Information System (INIS)

    Ellis, J.

    1983-01-01

    Part I of these lectures treats the standard Glashow-Weinberg-Salam model of weak and electromagnetic interactions, discussing in turn its basic structure and weak neutral currents, charged currents, mixing angles and CP violation, and the phenomenology of weak vector and Higgs bosons. Part II of the lectures discusses the structure of theories of dynamical symmetry breaking such as technicolour, phenomenological consequences, frustrations and alternatives. The third part of these lectures offers the standard menu of grand unified theories (GUTs) of the strong, weak and electromagnetic interactions, including an hors d'oeuvre of constraints on the parameters of the standard model, a main course of baryon number violating processes, and desserts which violate lepton number and CP. The fourth and final part goes through different attempts to remedy the inadequacies of previous theories by invoking supersymmetry and reaching out towards gravitation. (orig./HSI)

  9. Unifying physical concepts of reality

    International Nuclear Information System (INIS)

    Gilbert, T.L.

    1983-01-01

    Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large and the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences

  10. Unified gauge theories with spontaneous symmetry breaking

    International Nuclear Information System (INIS)

    MacDowell, S.W.

    1975-01-01

    Unified gauge theories with spontaneous symmetry breaking are studied with a view to renormalize quantum field theory. Georgi-Glashow and Weinberg-Salam models to unify weak and electromagnetic interactions are discussed in detail. Gauge theories of strong interactions are also considered [pt

  11. A unifying philosophy of governance

    Directory of Open Access Journals (Sweden)

    Sankarshan Acharya

    2012-09-01

    Full Text Available Bertrand Russell won Nobel Prize for arguing that science has triumphed over religion. Since religions are based on god, Russell’s argument implies that science has triumphed over both religion and god. But neither Russell nor anyone else has ever defined religion and god, rationally. The assertion about triumph of science (which is founded on rationality over concepts such as religion and god (which are not defined rationally or scientifically in the extant literature cannot be rational. This paper offers a novel rational philosophical foundation for the concepts of god, religion and science in which the claim that science triumphs over religion is redundant. This paper also presents substantial new insights about epistemic truths to help resolve current problems facing humanity like financial moral hazard and terrorism which have unnerved nations worldwide. The humanity now begs to answer a fundamental question of how we can govern ourselves. This paper offers a coherent set of credible answers. In particular, it offers a coherent unified philosophy about how humans have universally formed beliefs to govern themselves and how this philosophy could help resolve current problems. The universal rendering of beliefs articulated here subsumes the extant characterization of probability beliefs in mathematics, science, engineering, economics, religion and philosophy. The universal beliefs so articulated in this paper obviate the currently prevalent philosophical conflicts between religion and science or between theism and atheism and paves the way for optimal governance for prosperity amid stability. This philosophy also offers a rational characterization of the spiritual notion of Nirvana or salvation of the soul and the notion of epistemic truth. The unifying philosophy can help humanity achieve unity, stability and prosperity, sans financial moral hazard, antagonism, wars, nuclear proliferation, global warming and atmospheric pollution.

  12. Toward a Unified AGN Structure

    Science.gov (United States)

    Kazanas, Demosthenes; Fukumura, Keigo; Shrader, Chris; Behar, Ehud; Contopoulosa, Ioannis

    2012-01-01

    We present a unified model for the structure and appearance of accretion powered sources across their entire luminosity range from galactic X-ray binaries (XRB) to luminous quasars, with emphasis on AG N and their phenomenology. Central to this model is the notion of MHD winds launched by the accretion disks that power these objects. These winds provide the matter that manifests as blueshifted absorption features in the UV and X-ray spectra of a large fraction of these sources; furthermore, their density distribution in the poloidal plane determines their "appearance" (i.e. the column and velocity structure of these absorption features and the obscuration of the continuum source) as a function of the observer inclination angle (a feature to which INTEGRAL has made significant contributions). This work focuses on just the broadest characteristics of these objects; nonetheless, it provides scaling laws that allow one to reproduce within this model the properties of objects extending in luminosity from luminous quasars to XRBs. Our general conclusion is that the AGN phenomenology can be accounted for in terms of three parameters: The wind maSS flux in units of the Eddington value, m(dot), the observers' inclination angle Theta and the logarithmic slope between the 0/UV and X-ray fluxes alpha(sub ox); however because of a correlation between alpha(sub ox) and UV luminosity the number of significant parameters is two. The AGN correlations implied by this model appear to extend to and consistent with the XRB phenomenology, suggesting the presence of a truly unified underlying structure for accretion powered sources.

  13. Met1-linked Ubiquitination in Immune Signalling

    DEFF Research Database (Denmark)

    Fiil, Berthe Katrine; Gyrd-Hansen, Mads

    2014-01-01

    Methionine 1-linked ubiquitin chains (Met1-Ub), or linear ubiquitin, has emerged as a central post-translational modification in innate immune signalling. Molecular machinery that assembles, senses and, more recently, disassembles Met1-Ub has been identified, and technical advances have enabled...... identification of physiological substrates for Met1-Ub in response to activation of innate immune receptors. These discoveries have significantly advanced our understanding of how non-degradative ubiquitin modifications control pro-inflammatory responses mediated by nuclear factor κB and mitogen...

  14. Mars MetNet Mission Payload Overview

    Science.gov (United States)

    Harri, A.-M.; Haukka, H.; Alexashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.

    2012-09-01

    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide crucial scientific data about the Martian atmospheric phenomena.

  15. Seagrass from Unified Florida Reef Tract Map (NODC Accession 0123059)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a subset of the Unified Map representing Seagrass areas. Version 1.1 - December 2013. The Unified Florida Reef Tract Map (Unified Reef Map) provides...

  16. Gesloten kringloop met omgekeerde osmose of membraandestilatie

    NARCIS (Netherlands)

    Stijger, H.; Os, van E.A.

    2011-01-01

    TNO heeft samen met Wageningen UR Glastuinbouw een inventarisatie uitgevoerd naar geschikte zuiveringstechnieken om de waterstroom op tuinbouwbedrijven gesloten te krijgen. Uit de haalbaarheidstudie komen twee veelbelovende technieken naar voren die op vrij korte termijn inzetbaar zijn: omgekeerde

  17. Mars MetNet Mission Status

    Science.gov (United States)

    Harri, A.-M.; Aleksashkin, S.; Arruego, I.; Schmidt, W.; Genzer, M.; Vazquez, L.; Haukka, H.; Palin, M.; Nikkanen, T.

    2015-10-01

    New kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semihard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

  18. Mars MetNet Precursor Mission Status

    Science.gov (United States)

    Harri, A.-M.; Aleksashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.; Haukka, H.

    2013-09-01

    We are developing a new kind of planetary exploration mission for Mars in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

  19. Bio-composiet : Thermoplastische kunsstof met natuurvezels

    NARCIS (Netherlands)

    Beurden, van K.M.M. (Karin); Goselink, E.A. (Erik)

    2013-01-01

    Een biocomposiet wordt samengesteld uit een vezel en een hars. In dit document worden twee verwerkingsvormen van biocomposieten behandeld: - Vezel/poeder versterkt kunststof (granulaat); - Kunststof plaatmateriaal versterkt met een weefsel (laminaat), ook wel Sizopreg® genoemd. Door een

  20. Intern transport beter te plannen met computer

    NARCIS (Netherlands)

    Annevelink, E.

    1999-01-01

    Verbetering van intern transport in de potplantenteelt. Door getoetste vuistregels te combineren met toegepaste wiskunde is automatische planning van het intern transport binnen handbereik. Dit leidt tot minder transportbewegingen en tijdsbesparing bij het plannen

  1. Fosfaatwerking ogranische meststoffen vergelijkbaar met kunstmest

    NARCIS (Netherlands)

    Ehlert, P.A.I.; Pasterkamp, H.P.

    2000-01-01

    Gegevens in bijgaande tabel: Indicatieve fosfaatgehalten en de relatieve verdeling over mineraalfosfaat en organisch gebonden fosfaat in meststoffen met per mestsoort gegevens over het totaal fosfaatgehalte, het percentage mineraal fosfaat en het percentage organisch fosfaat

  2. Technisch lego met een Duplo-interface

    NARCIS (Netherlands)

    Pimentel, A.; Schipper, D.

    2008-01-01

    Daedalus is een ontwerpflow op systeemniveau waarmee techneuten snel kunnen experimenteren met verschillende multiprocessorarchitecturen tijdens de vroege stadia van het ontwerptraject. Het is het resultaat van tien jaar onderzoek en ontwikkeling binnen de Progress-projecten Artemis en Artemisia.

  3. Extraboard performance : TriMet case study.

    Science.gov (United States)

    2012-02-01

    This paper examines extraboard operations and management at TriMet, the transit provider for the Portland Oregon metropolitan area. The : extraboard consists of a pool of operators who fill open work resulting from absences and other causes. The pape...

  4. MMPM - Mars MetNet Precursor Mission

    Science.gov (United States)

    Harri, A.-M.; Schmidt, W.; Pichkhadze, K.; Linkin, V.; Vazquez, L.; Uspensky, M.; Polkko, J.; Genzer, M.; Lipatov, A.; Guerrero, H.; Alexashkin, S.; Haukka, H.; Savijarvi, H.; Kauhanen, J.

    2008-09-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. Prototyping of the payload instrumentation with final dimensions was carried out in 2003-2006.This huge development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development. To understand the behavior and dynamics of the Martian atmosphere, a wealth of simultaneous in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes. This will be performed by the Mars MetNet Mission. In addition to the science aspects the

  5. Mail Office

    CERN Multimedia

    GS Department

    2009-01-01

    The Mail Office wishes to remind users that the CERN mail service is exclusively reserved for official CERN mail. All external official mail must be sent to the Mail Office in an unstamped envelope on which your name and Department must be clearly indicated below the official CERN address (see example) to help us to find you in the event that it cannot be delivered. If you wish to send private mail from the CERN site you must use the post offices at Meyrin (63-R-011) or Prévessin (866-R-C02). Please use "PRIORITY" envelopes only in the case of urgent mail. Any mail containing merchandise (i.e. anything other than documents) must be sent using an EDH shipping request form. INTERNAL MAIL Please remember to include the recipient’s MAILBOX number on the internal mail envelopes, either in the relevant box (new envelopes) or next to the name (old envelopes). This information, which can be found in the CERN PHONEBOOK, simplifies our t...

  6. Mars MetNet Mission Status

    Science.gov (United States)

    Harri, Ari-Matti; Aleksashkin, Sergei; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Haukka, Harri

    2015-04-01

    New kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. 1. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. 2. Scientific Payload The payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: 1. MetBaro Pressure device 2. MetHumi Humidity device 3. MetTemp Temperature sensors Optical devices: 1. PanCam Panoramic 2. MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer 3. DS Dust sensor The descent processes dynamic properties are monitored by a special 3-axis accelerometer combined with a 3-axis gyrometer. The data will be sent via auxiliary beacon antenna throughout the

  7. Officer Overexecution: Analysis and Solutions (Technical Background)

    Science.gov (United States)

    2015-08-01

    298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18 i Abstract Understanding surface warfare officer (SWO) retention is critical for...civilian economy. We estimate that a one-unit increase in an index of macroeconomic activity (indicating a worsening of the economy) increases...officer requirements can be met. Thus, understanding the factors that affect SWO retention is critical for SWO accession planning and community

  8. A Product Line Enhanced Unified Process

    DEFF Research Database (Denmark)

    Zhang, Weishan; Kunz, Thomas

    2006-01-01

    The Unified Process facilitates reuse for a single system, but falls short handling multiple similar products. In this paper we present an enhanced Unified Process, called UPEPL, integrating the product line technology in order to alleviate this problem. In UPEPL, the product line related activit...... activities are added and could be conducted side by side with other classical UP activities. In this way both the advantages of Unified Process and software product lines could co-exist in UPEPL. We show how to use UPEPL with an industrial mobile device product line in our case study....

  9. A Unified Grand Tour of Theoretical Physics

    CERN Document Server

    Lawrie, Ian D

    2002-01-01

    A unified account of the principles of theoretical physics, A Unified Grand Tour of Theoretical Physics, Second Edition stresses the inter-relationships between areas that are usually treated as independent. The profound unifying influence of geometrical ideas, the powerful formal similarities between statistical mechanics and quantum field theory, and the ubiquitous role of symmetries in determining the essential structure of physical theories are emphasized throughout.This second edition conducts a grand tour of the fundamental theories that shape our modern understanding of the physical wor

  10. The unified theory of nuclear reactions

    International Nuclear Information System (INIS)

    Tobocman, W.

    A unified nuclear reaction theory is a formalism for the scattering reactions of many-body nuclear systems which is capable of describing both direct interaction and compound nucleus formation processes. The Feshbach projection operator formalism is the original unified nuclear reaction theory. An alternative unified nuclear reaction theory called the X-matrix formalism is described. The X-matrix formalism is a generalization of the Brown-de Dominicis formalism. It does not require projection operators and is readly applied to rearrangement collisions

  11. A unifying conceptual model of entrepreneurial management

    DEFF Research Database (Denmark)

    Senderovitz, Martin

    This article offers a systematic analysis and synthesis of the area of entrepreneurial management. Through a presentation of two main perspectives on entrepreneurial management and a newly developed unifying conceptual entrepreneurial management model, the paper discusses a number of theoretical...

  12. Unified data model for biological data

    International Nuclear Information System (INIS)

    Idrees, M.

    2014-01-01

    A data model empowers us to store, retrieve and manipulate data in a unified way. We consider the biological data consists of DNA (De-Oxyribonucleic Acid), RNA (Ribonucleic Acid) and protein structures. In our Bioinformatics Lab (Bioinformatics Lab, Alkhawarizmi Institute of Computer Science, University of Engineering and Technology, Lahore, Pakistan), we have already proposed two data models for DNA and protein structures individually. In this paper, we propose a unified data model by using the data models of TOS (Temporal Object Oriented System) after making some necessary modifications to this data model and our already proposed the two data models. This proposed unified data model can be used for the modeling and maintaining the biological data (i.e. DNA, RNA and protein structures), in a single unified way. (author)

  13. 76 FR 19893 - Unified Command Plan 2011

    Science.gov (United States)

    2011-04-08

    ... Plan 2011 Memorandum for the Secretary of Defense Pursuant to my authority as Commander in Chief, I hereby approve and direct the implementation of the revised Unified Command Plan. Consistent with title...

  14. Development of unified gauge theories: retrospect

    International Nuclear Information System (INIS)

    Lee, B.W.

    1977-01-01

    The construction and development of unified gauge theory of weak, electromagnetic, and strong interactions is reviewed. The Weinberg and Lee contributions to this study are mainly considered as personal recollections

  15. Unified universal quantum cloning machine and fidelities

    Energy Technology Data Exchange (ETDEWEB)

    Wang Yinan; Shi Handuo; Xiong Zhaoxi; Jing Li; Mu Liangzhu [School of Physics, Peking University, Beijing 100871 (China); Ren Xijun [School of Physics and Electronics, Henan University, Kaifeng 4750011 (China); Fan Heng [Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China)

    2011-09-15

    We present a unified universal quantum cloning machine, which combines several different existing universal cloning machines together, including the asymmetric case. In this unified framework, the identical pure states are projected equally into each copy initially constituted by input and one half of the maximally entangled states. We show explicitly that the output states of those universal cloning machines are the same. One importance of this unified cloning machine is that the cloning procession is always the symmetric projection, which reduces dramatically the difficulties for implementation. Also, it is found that this unified cloning machine can be directly modified to the general asymmetric case. Besides the global fidelity and the single-copy fidelity, we also present all possible arbitrary-copy fidelities.

  16. Unified Approach in the DSS Development Process

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

  17. Unified Chiral models of mesons and baryons

    International Nuclear Information System (INIS)

    Mendez-Galain, R.; Ripka, G.

    1990-01-01

    Unified Chiral models of mesons and baryons are presented. Emphasis is placed on the underlying quark structure of hadrons including the Skyrmion. The Nambu Jona-Lasinio model with vector mesons is discussed

  18. MetBaro - Pressure Device for Mars MetNet Lander

    Science.gov (United States)

    Haukka, Harri; Polkko, Jouni; Harri, Ari-Matti; Schmidt, Walter; Leinonen, Jussi; Genzer, Maria; Mäkinen, Teemu

    2010-05-01

    MetNet Mars Mission focused for Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetBaro is the pressure sensor of MetNet Lander designed to work on Martian surface. It is based on Barocap® technology developed by Vaisala, Inc. MetBaro is a capacitive type of sensing device where capasitor plates are moved by ambient pressure. MetBaro device consists of two pressure transducers including a total of 4 Barocap® sensor heads of high-stability and high-resolution types. The long-term stability of MetBaro is in order of 20…50 µBar and resolution a few µBar. MetBaro is small, lightweighed and has low power consumption. It weighs about 50g without wires and controlling FPGA, and consumes 15 mW of power. A similar device has successfully flown in Phoenix mission, where it performed months of measurements on Martian ground. Another device is also part of the Mars Science Laboratory REMS instrument (to be launched in 2011).

  19. MetHumi - Humidity Device for Mars MetNet Lander

    Science.gov (United States)

    Genzer, Maria; Polkko, Jouni; Harri, Ari-Matti; Schmidt, Walter; Leinonen, Jussi; Mäkinen, Teemu; Haukka, Harri

    2010-05-01

    MetNet Mars Mission focused for Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetHumi is the humidity sensor of MetNet Lander designed to work on Martian surface. It is based on Humicap® technology developed by Vaisala, Inc. MetHumi is a capacitive type of sensing device where an active polymer film changes capacitance as function of relative humidity. One MetHumi device package consists of one humidity transducer including three Humicap® sensor heads, an accurate temperature sensor head (Thermocap® by Vaisala, Inc.) and constant reference channels. MetHumi is very small, lightweighed and has low power consumption. It weighs only about 15 g without wires, and consumes 15 mW of power. MetHumi can make meaningful relative humidity measurements in range of 0 - 100%RH down to -70°C ambient temperature, but it survives even -135°C ambient temperature.

  20. C-MET overexpression and amplification in gliomas.

    Science.gov (United States)

    Kwak, Yoonjin; Kim, Seong-Ik; Park, Chul-Kee; Paek, Sun Ha; Lee, Soon-Tae; Park, Sung-Hye

    2015-01-01

    We investigated c-Met overexpression and MET gene amplification in gliomas to determine their incidence and prognostic significance. c-Met immunohistochemistry and MET gene fluorescence in situ hybridization were carried out on tissue microarrays from 250 patients with gliomas (137 grade IV GBMs and 113 grade II and III diffuse gliomas). Clinicopathological features of these cases were reviewed. c-Met overexpression and MET gene amplification were detected in 13.1% and 5.1% of the GBMs, respectively. All the MET-amplified cases showed c-Met overexpression, but MET amplification was not always concordant with c-Met overexpression. None of grade II and III gliomas demonstrated c-Met overexpression or MET gene amplification. Mean survival of the GBM patients with MET amplification was not significantly different from patients without MET amplification (P=0.155). However, GBM patients with c-Met overexpression survived longer than patients without c-Met overexpression (P=0.035). Although MET amplification was not related to poor GBM prognosis, it is partially associated with the aggressiveness of gliomas, as MET amplification was found only in grade IV, not in grade II and III gliomas. We suggest that MET inhibitor therapy may be beneficial in about 5% GBMs, which was the incidence of MET gene amplification found in the patients included in this study.

  1. Toward a unified representation system of performance-related data

    Energy Technology Data Exchange (ETDEWEB)

    Hailemariam, Ebenezer; Glueck, Michael; Attar, Ramtin; Tessier, Alex; McCrae, James; Khan, Azam [Autodesk Research, Toronto, Ontario (Canada)], email: first.last@autodesk.com

    2010-07-01

    When performing a building performance analysis many interacting factors have to be taken into account. Moreover, buildings have a changing behavior due to the ever changing occupants and context. To assess a building's performance, then, an important amount of data has to be studied and the aim of this paper is to present the advances made in the creation of a unified framework where all data can be visualized in a high resolution 3D model. Existing visualization methods are combined into a single framework and both simulated and measured building performance data are used. The model has been tested on the author's office building in Toronto, Ontario, Canada. The 3D model under development herein will help users make better use of their massive datasets and understand and analyze a building through its entire life whereas traditional 2D visualization methods make it difficult to interpret all data.

  2. Office of Child Care

    Science.gov (United States)

    ... for Children & Families Office of Child Care By Office Administration for Native Americans (ANA) Administration on Children, ... about the Child Care Rule > What is the Office of Child Care (OCC)? The Office of Child ...

  3. Samen in Zee met Zelfregulatie: Een Design-Based Aanpak met Vmbo Leraren

    NARCIS (Netherlands)

    Jossberger, Helen; Brand-Gruwel, Saskia; Boshuizen, Els; Van de Wiel, Margje

    2010-01-01

    Jossberger, H., Brand-Gruwel, S., Boshuizen, H. P. A., & Van der Wiel, M. (2010, June). Samen in Zee met Zelfregulatie: Een Design-Based Aanpak met Vmbo Leraren. Poster presented at the 37th Onderwijs Research Dagen (ORD), Enschede, Nederland.

  4. MetBaro - Pressure Instrument for Mars MetNet Lander

    Science.gov (United States)

    Polkko, J.; Haukka, H.; Harri, A.-M.; Schmidt, W.; Leinonen, J.; Mäkinen, T.

    2009-04-01

    THE METNET MISSION FOCUSED ON THE Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetBaro is the pressure instrument of MetNet Lander designed to work on Martian surface. It is based on Barocap® technology developed by Vaisala, Inc. MetBaro is a capacitic type of sensing device where capasitor plates are moved by ambient pressure. MetBaro device consists of two pressure transducers including a total of 6 Barocap® sensor heads of high-stability and high-resolution types. The long-term stability of MetBaro is in order of 20…50 µBar and resolution a few µBar. MetBaro is small, lightweighed and has low power consumption. It weighs about 50g without wires and controlling FPGA, and consumes 15 mW of power. A similar device has successfully flown in Phoenix mission, where it performed months of measurements on Martian ground. Another device is also part of the Mars Science Laboratory REMS instrument (to be launched in 2011).

  5. Inhaken met sociale media in 60 minuten

    NARCIS (Netherlands)

    Thijs Waardenburg; Komala Mazerant

    2018-01-01

    Met creatieve content die slim inhaakt op actuele gebeurtenissen kun je elke dag nieuwe mensen bereiken. Goedkoper dan adverteren op sociale media, en sympathieker bovendien.Thijs Waardenburg en Komala Mazerant leggen uit hoe je kansrijke inhakers bedenkt en communiceert om je bereik op sociale

  6. Varroabestrijding met bijenbroed als mijtenval (2)

    NARCIS (Netherlands)

    Calis, J.; Beetsma, J.; Boot, W.J.; Eijnde, van den J.; Ruijter, de A.

    1994-01-01

    Bij deze bestrijdingsmethode worden belegde darreraten uit een moergoede veger overgehangen naar het moerloze en later broedloze hoofdvolk. Hier worden de mijten die zich op de bijen bevinden gevangen. Nadat de laatste darreraat uit een hoofdvolk is verwijderd, wordt het bijenvolk met Perizine

  7. Beeldverwerking met de Micron Automatic Processor

    OpenAIRE

    Goyens, Frank

    2017-01-01

    Deze thesis is een onderzoek naar toepassingen binnen beeldverwerking op de Micron Automata Processor hardware. De hardware wordt vergeleken met populaire hedendaagse hardware. Ook bevat dit onderzoek nuttige informatie en strategieën voor het ontwikkelen van nieuwe toepassingen. Bevindingen in dit onderzoek omvatten proof of concept algoritmes en een praktische toepassing.

  8. Groen proceswater: zuivering brouwerijprocesafvalwater met microalgen

    NARCIS (Netherlands)

    Dijk, van W.; Weide, van der R.Y.; Kroon, A.

    2016-01-01

    In 2012 is het project Groen Proceswater gestart. Hierin worden de mogelijkheden van zuivering van brouwerijprocesafvalwater met behulp van microalgen onderzocht. Dit is gedaan in een samenwerkingsverband van Heineken Nederland BV, Algae Food & Fuel en WUR-ACRRES. De resultaten behaald in 2012

  9. Evangelisch Commando, onze omgamg met de buitenkerkelijke ...

    African Journals Online (AJOL)

    Test

    Of J. en E. dus interkerklik is, bly 'n vraag! Die gedeelte oor die „Oorzaken van buitenkerklijkheid is prikkelend en interessant. Die vraag is net of dit nie nog dieper gesoek moet word, nl. in die herontwaking van die Heidendom wat sig sins die Renaissance hardnekkig deur sit met die outonomie van die mens in die sentrum.

  10. Risicoanalyse voor buisleidingen met brandbare vloeistoffen

    NARCIS (Netherlands)

    van Vliet AAC; Laheij GMH; Wolting AG; CEV

    2006-01-01

    De minimale veiligheidsafstanden tussen buisleidingen met brandbare vloeistoffen en bebouwingen kunnen gelijk blijven of iets verkleind worden. Dit is de conclusie na een herberekening van de afstanden uit een circulaire uit 1991. In Nederland ligt zo'n 1850 kilometer aan ondergrondse buisleiding

  11. A brief report on mets system

    Digital Repository Service at National Institute of Oceanography (India)

    Fernandes, W.A.

    Mets system is basically a gas monitoring system, used for the detection of underwater gas. The system consists of a sensor, datalogger and energy module. The sensor works on the diffusion techniques. The system can be deployed to a water depth...

  12. Unified theory in the worldline approach

    Directory of Open Access Journals (Sweden)

    James P. Edwards

    2015-11-01

    Full Text Available We explore unified field theories based on the gauge groups SU(5 and SO(10 using the worldline approach for chiral fermions with a Wilson loop coupling to a background gauge field. Representing path ordering and chiral projection operators with functional integrals has previously reproduced the sum over the chiralities and representations of standard model particles in a compact way. This paper shows that for SU(5 the 5¯ and 10 representations – into which the Georgi–Glashow model places the left-handed fermionic content of the standard model – appear naturally and with the familiar chirality. We carry out the same analysis for flipped SU(5 and uncover a link to SO(10 unified theory. We pursue this by exploring the SO(10 theory in the same framework, the less established unified theory based on SU(6 and briefly consider the Pati–Salam model using SU(4×SU(2×SU(2.

  13. De Doop met de Heilige Geest

    Directory of Open Access Journals (Sweden)

    S. C.W. Duvenage.

    1965-03-01

    Full Text Available Ds. Molenaar begin sy boek, waarvan hy self die publikasienie beleef het nie, deur te wys op 'n groot tekort, ’n manko,nie alleen in die Gereformeerde vroomheid of lewe nie maarook in die Gereformeerde teologie. Hy beskou dit as hoogsmerkwaardig dat die Gereformeerde teologie in die verledeso goed as niks raakgesien het van die groot betekenis vandie sogenaamde doop met die Heilige Gees nie. Daarby meenhy dat die Gereformeerde predikante verleë sit met die Pinkterfees.Talle probleme meen hy vir die Gereformeerde teoloograak te sien, veral ten aansien van die moontlikhede van dieGees teenoor die so tasbare „onmoontIikhede” in ons lewe. Dieprobleme is syns insiens nie onoplosbaar nie, as mens maardie moontlikhede van die Gees nie beperk tot die verlede nie.

  14. MET and Small-Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Francesco Gelsomino

    2014-10-01

    Full Text Available Small-cell lung cancer (SCLC is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC.

  15. Metáfora y estructura conceptual

    Directory of Open Access Journals (Sweden)

    Emilia Castaño

    2012-01-01

    Full Text Available La lingüística cognitiva siempre ha argumentado que la metáfora no pertenece exclusivamente al lenguaje, sino que es una competencia que se basa en la habilidad humana de concebir un dominio de experiencia en términos de otro. Entendida así, la metáfora no puede ser otra cosa que un fenómeno conceptual. No obstante, pocos adeptos de la lingüística cognitiva han concentrados sus esfuerzos en catalogar manifestaciones metafóricas en ámbitos no lingüísticos. En este trabajo, sugerimos que es factible encontrar pruebas de que la metáfora es un proceso conceptual y, como tal, se manifiesta en esferas que no son estrictamente lingüísticas. Para ello, aportamos un seguido de evidencias muy diversas, como por ejemplo su papel en el razonamiento lógico-matemático de los niños en la fase preoperacional del desarrollo cognitivo, la programación de interfaces para aplicaciones informáticas y los resultados de tres estudios empíricos realizados recientemente en el campo  de la psicología cognitiva que analizan los efectos whorfianos en la conceptualización del tiempo y los efectos del espacio en la memoria emocional.

  16. A unified transmission loss allocation method

    International Nuclear Information System (INIS)

    Ding, Qifeng; Abur, Ali

    2007-01-01

    A new unified method which allocates transmission losses either to buses in a pool market or to individual transactions in a bilateral contract market is presented in this paper. A detailed derivation of the method is given. A bus-loss matrix and a transaction-loss matrix are developed to show the interactions between bus injections and transactions. It is further demonstrated that the ''Physical-power-flow-based'' method can be obtained as an approximation of this unified approach under certain simplifying assumptions. Test systems are used to illustrate how the proposed method behaves under different possible scenarios. (author)

  17. Unifying distribution functions: some lesser known distributions.

    Science.gov (United States)

    Moya-Cessa, J R; Moya-Cessa, H; Berriel-Valdos, L R; Aguilar-Loreto, O; Barberis-Blostein, P

    2008-08-01

    We show that there is a way to unify distribution functions that describe simultaneously a classical signal in space and (spatial) frequency and position and momentum for a quantum system. Probably the most well known of them is the Wigner distribution function. We show how to unify functions of the Cohen class, Rihaczek's complex energy function, and Husimi and Glauber-Sudarshan distribution functions. We do this by showing how they may be obtained from ordered forms of creation and annihilation operators and by obtaining them in terms of expectation values in different eigenbases.

  18. Technical writing practically unified through industry

    Science.gov (United States)

    Houston, L. S.

    1981-01-01

    General background details in the development of a university level technical writing program, based upon the writing tasks of the student's occupations, are summarized. Objectives and methods for unifying the courses of study with the needs of industry are discussed. Four academic course divisions, Industries Technologies, in which preparation and training are offered are: Animal, Horticulture, Agriculture, and Agricultural Business. Occupational competence is cited as the main goal for these programs in which technical writing is to be practically unified through industry. Course descriptions are also provided.

  19. Prospects of a Unified Management System

    DEFF Research Database (Denmark)

    Jørgensen, Tine Herreborg; Simonsen, Gorm

    2002-01-01

    In this article, the trend among management systems towards a common structure and the inclusion of additional areas of corporate concern (quality, environment, occupational health and safety and social responsibility) is outlined. The article suggests that a large part of the work associated...... with implementing and maintaining standardised management systems can be rationalised by developing a ?unified system?. The unified system is proposed to consist of a common basic standard of general managerial methodology expandable with supplements, which are related to the specific areas of concern...

  20. The unified coordination language UnCL.

    NARCIS (Netherlands)

    F.S. de Boer (Frank); J.V. Guillen Scholten (Juan); J.F. Jacob (Joost)

    2005-01-01

    textabstractIn this paper we show how to use a (subset) of UML as an Unified Coordination Language (UnCL) that is based on a separation of concerns between coordination and computation. As such UnCL provides a general language for the coordination of, in particular, object-oriented applications. The

  1. A Unified Introduction to Ordinary Differential Equations

    Science.gov (United States)

    Lutzer, Carl V.

    2006-01-01

    This article describes how a presentation from the point of view of differential operators can be used to (partially) unify the myriad techniques in an introductory course in ordinary differential equations by providing students with a powerful, flexible paradigm that extends into (or from) linear algebra. (Contains 1 footnote.)

  2. Unifying Learning Object Repositories in MACE

    NARCIS (Netherlands)

    Prause, Christian; Ternier, Stefaan; De Jong, Tim; Apelt, Stefan; Scholten, Marius; Wolpers, Martin; Eisenhauer, Markus; Vandeputte, Bram; Specht, Marcus; Duval, Erik

    2007-01-01

    Prause, C., Ternier, S., De Jong, T., Apelt, S., Scholten, M., Wolpers, M., et al. (2007). Unifying Learning Object Repositories in MACE. In D. Massart, J.-N. Colin & F. V. Assche (Eds.). Proceedings of the First International Workshop on Learning Object Discovery & Exchange (LODE'07). September,

  3. Unify a hazardous materials/waste program

    International Nuclear Information System (INIS)

    Carson, H.T.

    1988-01-01

    Efficiently managing a hazardous materials/waste program in a multi-facility, multi-product corporation is a major challenge. This paper describes several methods to help unify a program and gain maximum efficiency of manpower and to minimize risk

  4. A unified theory in higher dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Kapetanakis, D. (National Research Centre for the Physical Sciences Democritos, Athens (Greece)); Zoupanos, G. (European Organization for Nuclear Research, Geneva (Switzerland))

    1990-10-11

    We present a grand unified model defined in ten dimensions and based on the group SO(13). The model is dimensionally reduced over the non-simply-connected space (Su(3)/U(1)xU(1))/Z{sub 2} giving in four dimensions the standard model. (orig.).

  5. A unified theory in higher dimensions

    International Nuclear Information System (INIS)

    Kapetanakis, D.; Zoupanos, G.

    1990-01-01

    We present a grand unified model defined in ten dimensions and based on the group SO(13). The model is dimensionally reduced over the non-simply-connected space [Su(3)/U(1)xU(1)]/Z 2 giving in four dimensions the standard model. (orig.)

  6. Toward a Unified Theory of Human Reasoning.

    Science.gov (United States)

    Sternberg, Robert J.

    1986-01-01

    The goal of this unified theory of human reasoning is to specify what constitutes reasoning and to characterize the psychological distinction between inductive and deductive reasoning. The theory views reasoning as the controlled and mediated application of three processes (encoding, comparison and selective combination) to inferential rules. (JAZ)

  7. IDEA: A Unifying Theory for Evaluation Systems

    DEFF Research Database (Denmark)

    Bella, Giampaolo; Giustolisi, Rosario

    2017-01-01

    Secure systems for voting, exams, auctions and conference paper management are theorised to address the same problem, that of secure evaluations. In support of such a unifying theory comes a model for Secure Evaluation Systems (SES), which offers innovative common grounds to understand all four...

  8. Lipid ratio as a suitable tool to identify individuals with MetS risk: A case- control study.

    Science.gov (United States)

    Abbasian, Maryam; Delvarianzadeh, Mehri; Ebrahimi, Hossein; Khosravi, Farideh

    2017-11-01

    This study aimed to compare the serum lipids ratio in staff with and without metabolic syndrome (MetS) who were working in Shahroud University of Medical Sciences. This case-control study was conducted in 2015 on 499 personnel aged 30-60 years old. ATP III criteria were used to diagnose patients with MetS. The data were analyzed by using logistic regression and ROC curve. Mean lipid ratio was higher in individuals having the MetS in both sexes compared with those without. In addition, the mean levels of lipid ratios significantly increased with increasing number of MetS components in both sexes. Also it could be concluded that TG/HDL-C ratio is the best marker for the diagnosis of MetS in men and women. Moreover, the cut-off point for the TG/HDL-C was 2.86 in women and 4.03 in men. It was found that for any unit of increases in the TG/HDL-C, the risk of developing the MetS will increase by 2.12 times. TG/HDL-C ratio is found to be the best clinical marker for the diagnosis of MetS compare with other lipid ratios, therefore it is recommended to be used as a feasible tool to identify individuals with MetS risk. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  9. Metáfora y conceptos abstractos

    OpenAIRE

    Danesi, Marcel

    2006-01-01

    La gran cantidad de datos recolectados sobre la metáfora sugiere enfáticamente que muchos de los conceptos abstractos, si no la mayoría, son codificables y reconocibles primordialmente como «ideas metaforizadas», es decir como conceptos que se derivan cognitivamente mediante el razonamiento metafórico y un proceso de asociación metafórica que en este artículo se denominará estratificación [layering] (Gibbs, 1994; Goatley, 1997). La literatura más actualizada sobre lo que se ha denominado Teor...

  10. Radial and Regge excitations in unified, grand unified and subconstituent models

    International Nuclear Information System (INIS)

    Schnitzer, H.J.

    1981-01-01

    Necessary group theoretic conditions for all elementary gauge bosons and fermions of an arbitrary renormalizable gauge theory to lie on Regge trajectories are reviewed. It is then argued that in properly unified gauge theories all particles of a given spin lie on Regge trajectories. This then implies that a properly unified gauge theory has no local U(1) factor groups, and no massive fermion singlets. A consideration of the general pattern of Regge and radial recurrences to be expected in quantum field theories suggests that the presence or absence of spin 3/2 quarks and/or leptons in the TeV region will provide crucial clues to enable one to distinguish between various classes of unified, grand unified, and subconstituent models. The correct interpretation of such excited fermions will require correlation with the higgs boson mass and possible radial and Regge excitations of the weak vector bosons. (orig.)

  11. Unified treatment of the classical and quantum mechanics

    International Nuclear Information System (INIS)

    Shirokov, Yu.M.

    1979-01-01

    Classical and Quantum Mechanics are unified in the sense that almost all axioms of both mechanics are identical. The only distinction is the explicit form of one algebraic identity. The unified theory is applied to scattering problem. (Z.M.)

  12. designing a framework for a unified electronic identity system

    African Journals Online (AJOL)

    DJFLEX

    In this paper, a Unified Identity System is proposed where single electronic identity (eID) is issued that can be used ... online commerce and public sector organizations. Because ..... SearchUnifiedCommunications.com Definitions, Access date.

  13. Dissection of combinatorial control by the Met4 transcriptional complex.

    Science.gov (United States)

    Lee, Traci A; Jorgensen, Paul; Bognar, Andrew L; Peyraud, Caroline; Thomas, Dominique; Tyers, Mike

    2010-02-01

    Met4 is the transcriptional activator of the sulfur metabolic network in Saccharomyces cerevisiae. Lacking DNA-binding ability, Met4 must interact with proteins called Met4 cofactors to target promoters for transcription. Two types of DNA-binding cofactors (Cbf1 and Met31/Met32) recruit Met4 to promoters and one cofactor (Met28) stabilizes the DNA-bound Met4 complexes. To dissect this combinatorial system, we systematically deleted each category of cofactor(s) and analyzed Met4-activated transcription on a genome-wide scale. We defined a core regulon for Met4, consisting of 45 target genes. Deletion of both Met31 and Met32 eliminated activation of the core regulon, whereas loss of Met28 or Cbf1 interfered with only a subset of targets that map to distinct sectors of the sulfur metabolic network. These transcriptional dependencies roughly correlated with the presence of Cbf1 promoter motifs. Quantitative analysis of in vivo promoter binding properties indicated varying levels of cooperativity and interdependency exists between members of this combinatorial system. Cbf1 was the only cofactor to remain fully bound to target promoters under all conditions, whereas other factors exhibited different degrees of regulated binding in a promoter-specific fashion. Taken together, Met4 cofactors use a variety of mechanisms to allow differential transcription of target genes in response to various cues.

  14. Saving energy with paint. Coating with ceramic globules; Energie besparen met verf. Coating met keramische bolletjes

    Energy Technology Data Exchange (ETDEWEB)

    Willemse, R. [Coateq Coatings, Haarlem (Netherlands)

    2011-07-01

    The special paint coating of ThermoShield saves energy. The coating consists for 50% of hollow, vacuum ceramic globules. The waterborne damp-open coating with capillary function resists rain water and removes redundant water in case of draught and it reflects sunlight. [Dutch] Met de speciale verfcoating ThermoShield kan energie worden bespaard. De coating bestaat voor 50% uit holle, vacuum getrokken keramische bolletjes. De watergedragen damp-open coating met capillaire werking stoot bij regen water af en voert bij droogte overtollig vocht af en reflecteert zonlicht.

  15. Tidal analysis of Met rocket wind data

    Science.gov (United States)

    Bedinger, J. F.; Constantinides, E.

    1976-01-01

    A method of analyzing Met Rocket wind data is described. Modern tidal theory and specialized analytical techniques were used to resolve specific tidal modes and prevailing components in observed wind data. A representation of the wind which is continuous in both space and time was formulated. Such a representation allows direct comparison with theory, allows the derivation of other quantities such as temperature and pressure which in turn may be compared with observed values, and allows the formation of a wind model which extends over a broader range of space and time. Significant diurnal tidal modes with wavelengths of 10 and 7 km were present in the data and were resolved by the analytical technique.

  16. Metástasis hipofisaria Hypophyseal metastasis

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Yanes Quesada

    2009-04-01

    Full Text Available mayoría son lesiones silentes descubiertas accidentalmente en las autopsia. La aparición de metástasis sintomáticas es, en cambio, excepcional. DESARROLLO: se describen aquí los hallazgos clínicos y radiológicos de una paciente femenina de 69 años, con un carcinoma indiferenciado del pulmón, diagnosticado hace 2 años y medio, que comenzó con cefalea y trastornos visuales sin hipopituitarismo ni diabetes insípida. Se le realizó resonancia magnética nuclear y se le diagnosticó una lesión hipofisaria, que fue operada por vía tranesfenoidal, y se informó por anatomía patológica una metástasis del carcinoma del pulmón. CONCLUSIONES: la paciente se encuentra en estos momentos recibiendo quimioterapia, radioterapia y anticuerpo monoclonal con evolución favorable.INTRODUCTION: metastatic tumors of hypophyseal gland are infrequent. Most are silent lesions discovered accidentally in necropsy. Appearance of symptomatic metastasis is however, exceptional. DEVELOPMENT: we describe here clinical and radiological findings in a female patient aged 69, presenting with a non-differential carcinoma of lung, diagnosed two years a half ago, starting with headache and visual disorders without hypopituitarism and insipidus diabetes. We made a nuclear magnetic resonance and diagnosis was a hypophyseal lesion operated on by trans-esphenoidal route, and Pathological Anatomy Service reports a metastasis of lung carcinoma. CONCLUSIONS: patient receives chemotherapy, radiotherapy, and monoclonal antibody with a favorable evolution.

  17. Multi-planed unified switching topologies

    Science.gov (United States)

    Chen, Dong; Heidelberger, Philip; Sugawara, Yutaka

    2017-07-04

    An apparatus and method for extending the scalability and improving the partitionability of networks that contain all-to-all links for transporting packet traffic from a source endpoint to a destination endpoint with low per-endpoint (per-server) cost and a small number of hops. An all-to-all wiring in the baseline topology is decomposed into smaller all-to-all components in which each smaller all-to-all connection is replaced with star topology by using global switches. Stacking multiple copies of the star topology baseline network creates a multi-planed switching topology for transporting packet traffic. Point-to-point unified stacking method using global switch wiring methods connects multiple planes of a baseline topology by using the global switches to create a large network size with a low number of hops, i.e., low network latency. Grouped unified stacking method increases the scalability (network size) of a stacked topology.

  18. Finite Unified Theories and the Higgs boson

    CERN Document Server

    Heinemeyer, Sven; Zoupanos, George

    2012-01-01

    All-loop Finite Unified Theories (FUTs) are very interesting N = 1 supersymmetric Grand Unified Theories (GUTs) realising an old field theory dream, and moreover have a remarkable predictive power due to the required reduction of couplings. Based on this theoretical framework phenomenologically consistent FUTs have been constructed. Here we review two FUT models based on the SU(5) gauge group, which can be seen as special, restricted and thus very predictive versions of the MSSM. We show that from the requirement of correct prediction of quark masses and other experimental constraints a light Higgs-boson mass in the range M_h ~ 121 - 126 GeV is predicted, in striking agreement with recent experimental results from ATLAS and CMS. The model furthermore naturally predicts a relatively heavy spectrum with colored supersymmetric particles above ~ 1.5 TeV in agreement with the non-observation of those particles at the LHC.

  19. Can the laws of physics be unified ?

    CERN Document Server

    Langacker, Paul

    2017-01-01

    The standard model of particle physics describes our current understanding of nature's fundamental particles and their interactions, yet gaps remain. For example, it does not include a quantum theory of gravity, nor does it explain the existence of dark matter. Once complete, however, the standard model could provide a unified description of the very building blocks of the universe. Researchers have been chasing this dream for decades, and many wonder whether such a dream can ever be made a reality. Can the Laws of Physics Be Unified? is a short introduction to this exciting frontier of physics. The book is accessibly written for students and researchers across the sciences, and for scientifically minded general readers. Paul Langacker begins with an overview of the key breakthroughs that have shaped the standard model, and then describes the fundamental particles, their interactions, and their role in cosmology. He goes on to explain field theory, internal symmetries, Yang-Mills theories, strong and electro...

  20. Unified-field theory: yesterday, today, tomorrow

    International Nuclear Information System (INIS)

    Bergman, P.G.

    1982-01-01

    Beginning with the expounding of Einstein understanding of advantages and disadvantages of general relativity theory, the authors proceed to consideration of what the complete unified theory have to be according to Einstein. The four theories which can be considered as ''unified'', namely weyl and Calutsa ones, worked out a half of century ago, and twistor twisting and supersymmetry theories, nowadays attracting attention, are briefly described and discussed. The authors come to a conclusion that achievements in elementary-particle physics have to affect any future theory, that this theory has to explain the principle contradictions between classical and quantum field theories, and that finally it can lead to change of the modern space-time model as a four-dimensional variety

  1. Fermilab Education Office - FAQ

    Science.gov (United States)

    Search The Education Office FAQ - Frequently Asked Questions Click on the question to see the answer and the difference between the Education Office and the Lederman Science Center? The Education Office is store selling logo items and science toys. The Education Office staff works on both the 15th floor of

  2. Towards a Unified Global ICT Infrastructure

    DEFF Research Database (Denmark)

    Madsen, Ole Brun

    2006-01-01

    A successful evolution towards a unified global WAN platform allowing for the coexistence and interoperability of all kind of services requires careful planning of the next generation global cooperative wired and wireless information infrastructure. The absence of commonly agreed upon and adopted...... to be solved can be found in the interrelation between communication, connectivity and convergence. This paper will focus on steps to be taken in planning the physical infrastructure as a prerequisite for a successful evolution....

  3. Unified geometric description of black hole thermodynamics

    International Nuclear Information System (INIS)

    Alvarez, Jose L.; Quevedo, Hernando; Sanchez, Alberto

    2008-01-01

    In the space of thermodynamic equilibrium states we introduce a Legendre invariant metric which contains all the information about the thermodynamics of black holes. The curvature of this thermodynamic metric becomes singular at those points where, according to the analysis of the heat capacities, phase transitions occur. This result is valid for the Kerr-Newman black hole and all its special cases and, therefore, provides a unified description of black hole phase transitions in terms of curvature singularities.

  4. The group manifold approach to unified gravity

    International Nuclear Information System (INIS)

    Regge, T.

    1984-01-01

    These lectures start with a synopsis of historical results in the construction of unified theories of gravity. The author keeps some mathematical rigour throughout the lectures. He gives a provisional description of supermanifolds and a set of formal rules intended to manipulate superforms or supermanifolds. Super Lie groups are discussed as well as the dimensional reduction of gravity theories, the Kaluza-Klein theory. A formal introduction of supersymmetry is given. (Auth.)

  5. Unifying Ancient and Modern Geometries Through Octonions

    International Nuclear Information System (INIS)

    Catto, Sultan; Gürcan, Yasemin; Kurt, Levent; Khalfan, Amish

    2016-01-01

    We show the first unified description of some of the oldest known geometries such as the Pappus’ theorem with more modern ones like Desargues' theorem, Monge's theorem and Ceva's theorem, through octonions, the highest normed division algebra in eight dimensions. We also show important applications in hadronic physics, giving a full description of the algebra of color applicable to quark physics, and comment on further applications. (paper)

  6. A unified architecture of transcriptional regulatory elements

    DEFF Research Database (Denmark)

    Andersson, Robin; Sandelin, Albin Gustav; Danko, Charles G.

    2015-01-01

    Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However...... and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements....

  7. Neutrino mixing in a grand unified theory

    International Nuclear Information System (INIS)

    Milton, K.; Tanaka, K.

    1980-01-01

    Neutrino mixing in a grand unified theory in which the neutrino mass matrix is determined by the Gell-Mann-Ramond-Slansky mechanism was investigated. With an arbitrary real right-handed Majorana mass matrix which incorporates three neutrino mass scales, the effects of the up-quark mass matrix are found to be dominant and as a result no significant mixing of ν/sub e/ occurs, while ν/sub μ/ - ν/sub γ/ mixing can be substantial

  8. Towards a unified theory of reciprocity.

    Science.gov (United States)

    Rosas, Alejandro

    2012-02-01

    In a unified theory of human reciprocity, the strong and weak forms are similar because neither is biologically altruistic and both require normative motivation to support cooperation. However, strong reciprocity is necessary to support cooperation in public goods games. It involves inflicting costs on defectors; and though the costs for punishers are recouped, recouping costs requires complex institutions that would not have emerged if weak reciprocity had been enough.

  9. A Unified Framework for Systematic Model Improvement

    DEFF Research Database (Denmark)

    Kristensen, Niels Rode; Madsen, Henrik; Jørgensen, Sten Bay

    2003-01-01

    A unified framework for improving the quality of continuous time models of dynamic systems based on experimental data is presented. The framework is based on an interplay between stochastic differential equation (SDE) modelling, statistical tests and multivariate nonparametric regression. This co......-batch bioreactor, where it is illustrated how an incorrectly modelled biomass growth rate can be pinpointed and an estimate provided of the functional relation needed to properly describe it....

  10. Office 365 For Dummies

    CERN Document Server

    Withee, Ken

    2012-01-01

    The information you need to create a virtual office that can be accessed anywhere Microsoft Office 365 is a revolutionary technology that allows individuals and companies of all sizes to create and maintain a virtual office in the cloud. Featuring familiar Office Professional applications, web apps, Exchange Online, and Lync Online, Office 365 offers business professionals added flexibility and an easy way to work on the go. This friendly guide explains the cloud, how Office 365 takes advantage of it, how to use the various components, and the many possibilities offered by Office 365. It provi

  11. Resultaten boomkorsurvey 2013: BTS met onderzoeksvaartuigen Isis en Tridens (interview met Ingeborg de Boois)

    NARCIS (Netherlands)

    Boois, de I.J.

    2013-01-01

    Van begin augustus tot half september heeft IMARES de boomkorsurvey (BTS) uitgevoerd met de onderzoeksschepen Isis en Tridens. Op 29 maart 2014 wordt een bijeenkomst georganiseerd voor geinteresseerden, waar de resultaten van zowel de BTS als de bedrijfssurvey gepresenteerd worden. De BTS wordt

  12. Cosmic strings in unified gauge theories

    International Nuclear Information System (INIS)

    Everett, A.E.

    1981-01-01

    Some spontaneously broken gauge theories can give rise to stringlike vacuum structures (vortices). It has been pointed out by Vilenkin that in grand unified theories these can be sufficiently massive to have cosmological implications, e.g., in explaining the formation of galaxies. The circumstances in which such structures occur are examined. They do not occur in the simplest grand unified theories, but can occur in some more elaborate models which have been proposed. The cross section for the scattering of elementary particles by strings is estimated. This is used to evaluate the effect of collisions on the dynamics of a collapsing circular string, with particular attention to the question of whether energy dissipation by collision can reduce the rate of formation of black holes by collapsed strings, which may be unacceptably large in models where strings occur. It is found that the effect of collisions is not important in the case of grand unified strings, although it can be important for lighter strings

  13. Coset realization of unifying W-algebras

    International Nuclear Information System (INIS)

    Blumenhagen, R.; Huebel, R.

    1994-06-01

    We construct several quantum coset W-algebras, e.g. sl(2,R)/U(1) and sl(2,R)+sl(2,R)/sl(2,R), and argue that they are finitely nonfreely generated. Furthermore, we discuss in detail their role as unifying W-algebras of Casimir W-algebras. We show that it is possible to give coset realizations of various types of unifying W-algebras, e.g. the diagonal cosets based on the symplectic Lie algebras sp(2n) realize the unifying W-algebras which have previously been introduced as 'WD -n '. In addition, minimal models of WD -n are studied. The coset realizations provide a generalization of level-rank-duality of dual coset pairs. As further examples of finitely nonfreely generated quantum W-algebras we discuss orbifolding of W-algebras which on the quantum level has different properties than in the classical case. We demonstrate in some examples that the classical limit according to Bowcock and Watts of these nonfreely finitely generated quantum W-algebras probably yields infinitely nonfreely generated classical W-algebras. (orig.)

  14. Unified strength theory and its applications

    CERN Document Server

    Yu, Mao-Hong

    2004-01-01

    This is a completely new theory dealing with the yield and failure of materials under multi-axial stresses. It provides a system of yield and failure criteria adopted for most materials, from metallic materials to rocks, concretes, soils, polymers etc. The Unified Strength Theory has been applied successfully to analyse the elastic limit, plastic limit capacities, the dynamic response behavior for some structures under static and moderate impulsive load, and may be implemented in some elasto-plastic finite element computer codes. The Unified Strength Theory is described in detail and by using this theory a series of results can be obtained. The Unified Strength Theory can improve the conservative Mohr-Coulomb Theory, and since intermediate principal stress is not taken into account in the Mohr-Coulomb theory and most experimental data is not pertainable to the Mohr-Coulomb Theory, a considerable economic benefit may be obtained. The book can also increase the effect of most commercial finite element computer ...

  15. Proton decay in grand unified theories

    International Nuclear Information System (INIS)

    Lucha, W.

    1984-01-01

    Interactions which violate the conservation of baryon and lepton number represent an intrinsic part of all grand unified theories (GUTs) of strong and electroweak interactions. These new interactions - predicted within the framework of GUTs - generate B and L violating four-fermion interactions via the exchange of superheavy particles which cannot be ascribed a well-defined baryon or lepton number. The effective coupling constant of these four-fermion interactions might be large enough to make the proton decay detectable by the present generation of experiments. In this review the basic concepts of conventional as well as supersymmetric GUTs relevant for proton decay are sketched. The baryon number violating sector of grand unified theories is discussed in more detail. Special emphasis is laid on the various selection rules arising as consequences of low-energy gauge invariance and supersymmetry for proton decay. These selection rules already determine the coarse pattern of the resulting decay modes and branching ratios without any reference to or detailed knowledge of the underlying grand unified theory. Finally the numerous theoretical predictions are summarized and confronted with experiment. (Author)

  16. Milde voedselverwerkingstechnologie II : milde conservering met hoge druk : nieuwe ontwikkelingen

    NARCIS (Netherlands)

    Matser, A.M.; Ven, van der C.; Berg, van den R.

    2004-01-01

    Met behulp van hogedruktechnologie kunnen producten langer houdbaar worden gemaakt. Deze bekende techniek kent de laatste tijd nieuwe ontwikkelingen en toepassingen . Naast pasteuriseren door een hogedrukbehandeling bij kamertemperatuur is het nu ook mogelijk om te steriliseren met hoge druk. Ook

  17. MetNet Network Mission for Martian Atmospheric Investigations

    Science.gov (United States)

    Harri, A.-M.; Alexashkin, S.; Arrugeo, I.; Schmidt, W.; Vazquez, L.; Genzer, M.; Haukka, H.

    2014-07-01

    A new kind of planetary exploration mission for Mars called MetNet is being developed for martian atmospheric investigations. The eventual scope of the MetNet Mission is to deploy tens of small landers on the martian surface.

  18. Dimensionering van de Uniqfill chemischer wasser met lamellen

    NARCIS (Netherlands)

    Starmans, D.A.J.

    2006-01-01

    In dit rapport wordt een eerste aanzet gegeven tot de modellering van een kruisstroom chemische wasser met lamellen. Met behulp van bestaande metingen is de stofoverdrachtscoëfficiënt afgeschat, waarna scenario's voor nieuwe wassers doorgerekend konden worden.

  19. Klimaatverandering en de stadsboom (interview met Jitze Kopinga)

    NARCIS (Netherlands)

    Bennink, P.; Kopinga, J.

    2010-01-01

    Bomen in de stad staan vaak op warme plaatsen met een gebrekkige waterhuishouding. Volgens het KNMI zal Nederland in de toekomst steeds vaker met hitte en droogte te maken hebben. Wat betekent dat voor onze stadsbomen?

  20. MET amplification, expression, and exon 14 mutations in colorectal adenocarcinoma.

    Science.gov (United States)

    Zhang, Meng; Li, Guichao; Sun, Xiangjie; Ni, Shujuan; Tan, Cong; Xu, Midie; Huang, Dan; Ren, Fei; Li, Dawei; Wei, Ping; Du, Xiang

    2018-04-08

    MET amplification, expression, and splice mutations at exon 14 result in dysregulation of the MET signaling pathway. The aim of this study was to identify the relationship between MET amplification, protein or mRNA expression, and mutations in colorectal cancer (CRC). MET immunohistochemistry (IHC) was used for MET protein expression analysis and fluorescence in situ hybridization (FISH) was used for MET amplification detection. Both analyses were performed in tissue microarrays (TMA) containing 294 of colorectal adenocarcinoma tissue samples and 131 samples of adjacent normal epithelial tissue. MET mRNA expression was examined by real-time quantitative polymerase chain reaction (qRT-PCR) in 72 fresh colorectal adenocarcinoma tissue samples and adjacent normal colon tissue. PCR sequencing was performed to screen for MET exon 14 splice mutations in 59 fresh CRC tissue samples. Our results showed that MET protein expression was higher in colorectal tumor tissue than in adjacent normal intestinal epithelium. Positive MET protein expression was associated with significantly poorer overall survival (OS) and disease-free survival (DFS). Multivariate analysis revealed that positive MET protein expression was an independent risk factor for DFS, but not for OS. MET mRNA expression was upregulated in tumor tissues compared with the adjacent normal tissues. The incidence of MET amplification was 4.4%. None of the patients was positive for MET mutation. Collectively, MET was overexpressed in colorectal adenocarcinoma, and its positive protein expression predicted a poorer outcome in CRC patients. Furthermore, according to our results, MET amplification and 14 exon mutation are extremely rare events in colorectal adenocarcinoma. Copyright © 2018. Published by Elsevier Inc.

  1. Effect of MET on formation and vigor of wheat roots

    International Nuclear Information System (INIS)

    Wang Bingkui; Jin Ziyu; Zhao Miaozhen; Zhao Yanshen

    1993-01-01

    Effect of MET on the formation and vigor of roots of wheat seedlings were studied. The results showed that 50 ∼ 200 ppm MET inhibited vertical elongation of roots, increased root, shoot ratio and enhanced the formation and vigor of roots. But MET had no effect on the dry weight of roots. The activity of peroxidase was decreased and the proportion of assimilates in roots was increased by MET treatment compared with the control

  2. Innoveren met serious games : Wat is serious gaming?

    NARCIS (Netherlands)

    Werkhoven, P.J.

    2008-01-01

    Het begrip serious gaming is inmiddels gekaapt door vele aanbieders van wat vroeger simulatie en virtual reality technologie genoemd werd. Met die technologie kunnen we mensen laten rondlopen in virtuele gebouwen en landschappen, al dan niet met grote projectieschermen of met brillen op. Maar dat is

  3. Groen proceswater: zuivering brouwerijprocesafvalwater met microalgen : Resultaten onderzoek 2013

    NARCIS (Netherlands)

    Dijk, van W.; Diem, van A.; Doornbusch, P.; Grobben-Gaastra, S.A.; Kleinhout, G.; Kroon, A.; Weide, van der R.Y.

    2014-01-01

    Afgelopen jaar is de pilot met het kweken van algen met afvalwater van de brouwerijlocatie Zoeterwoude geslaagd. Dit is gedaan in een samenwerkingsverband van Heineken Nederland BV, Algae Food & Fuel en WUR-Acrres. Dit is de eerste inline pilot in de wereld waarbij met LED verlichting op 1000 L

  4. Erlotinib e metástases cerebrais

    Directory of Open Access Journals (Sweden)

    Fernando Barata

    2008-10-01

    Full Text Available Resumo: Relatamos dois casos de carcinoma pulmonar de não pequenas células (CPNPC com metástases cerebrais que após quimioterapia sistémica receberam em segunda e terceira linha erlotinib 150 mg/dia, oral, com resposta completa das lesões secundárias cerebrais e franca resposta parcial das lesões torácicas.A metastização cerebral, bastante prevalente no contexto do CPNPC, está associada a escassas opções terapêuticas eficazes e, consequentemente, a uma sobre-vida mediana de 4 a 6 meses.Estes casos alertam para o erlotinib como uma excelente opção terapêutica para estes doentes. Os autores propõem um ensaio clínico com este fármaco neste grupo de doentes, procurando determinar da resposta objectiva.Rev Port Pneumol 2008; XIV (Supl 3: S35-S42 Abstract: We report two cases of brain metastases in context of non small cell lung cancer (NSCLC. After having progressed to chemotherapy they received erlotinib 150 mg/m2 orally daily, with complete response of brain metastasis and partial response of thoracic lesions.Brain metastases are both prevalent and a major cause of mortality in NSCLC, with few systemic treatment options. Median survival after whole brain radiotherapy is 4-6 months and the role of systemic therapy for brain metastases is limited with the most drugs use to stage IV disease ineffective in this setting.This case demonstrates that brain metastases may be sensitive to erlotinib and give to us growing body of evidence that EGFR-associated tyrosine kinase inhibition is a feasible strategy in the management of NSCLC patients with brain metastasesWe propose further study into the continued use of this drug in the situation where there is a differential response.Rev Port Pneumol 2008; XIV (Supl 3: S35-S42 Palavras-chave: Erlotinib, metástase cerebral, cancro do pulmão, Key-words: Erlotinib, brain metastasis, lung cancer

  5. Phase I Trial of Anti-MET Monoclonal Antibody in MET-Overexpressed Refractory Cancer.

    Science.gov (United States)

    Lee, Jeeyun; Kim, Seung Tae; Park, Sungju; Lee, Sujin; Park, Se Hoon; Park, Joon Oh; Lim, Ho Yeong; Ahn, Hongmo; Bok, Haesook; Kim, Kyoung-Mee; Ahn, Myung Ju; Kang, Won Ki; Park, Young Suk

    2018-06-01

    Samsung Advance Institute of Technology-301 (SAIT301) is a human immunoglobulin G2 antibody that can specifically target mesenchymal epithelial transition factor (c-MET). This novel antibody has higher priority over hepatocyte growth factors when binding to the Sema domain of c-MET and accelerates the internalization and degradation of c-MET, proving its powerful antitumor activities in intra- as well as extracellular areas. SAIT301 was administered intravenously once every 3 weeks in c-MET overexpressed solid tumor patients, focusing on metastatic colorectal cancer (CRC) according to common clinical phase I criteria. Dose escalation was performed according to a modified Fibonacci design, following the conventional 3+3 design. The purpose of this phase I study was to assess the safety profile, to establish the recommended dose for clinical phase II studies and to assess potential anticancer activity of the compound. Sixteen patients with a median age of 56 (range, 39-69) years were enrolled in the study. The most common adverse events were decreased appetite (50.0%), hypophosphatemia, fatigue and dizziness (25.0%, respectively), and diarrhea, blood alkaline phosphatase increased and dyspnea (18.8%, respectively). For tumor response, no patients achieved complete response. One (9.1%) CRC patient had a partial response in the 1.23 mg/kg group, 4 (36.4%) patients achieved stable disease (2 in the 0.41 mg/kg group, 2 in the 1.23 mg/kg group, 0 in the 3.69 mg/kg group, and 1 in the 8.61 mg/kg group). Because of the increase in dose-limiting toxicities (DLTs) at 8.61 mg/kg, the 3.69 mg/kg dose was considered the maximum tolerated dose and selected for further assessment in phase II. We successfully completed a phase I trial with MET antibody in a MET-overexpressed patient population focusing on CRC, and found that the DLTs were alkaline phosphatase elevation or hypophosphatemia. The recommended dose of SAIT301 for phase II is the dose of 3.69 mg/kg. Copyright © 2018

  6. 3D RoboMET Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Madison, Jonathan D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Susan, Donald F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kilgo, Alice C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    The goal of this project is to generate 3D microstructural data by destructive and non-destructive means and provide accompanying characterization and quantitative analysis of such data. This work is a continuing part of a larger effort to relate material performance variability to microstructural variability. That larger effort is called “Predicting Performance Margins” or PPM. In conjunction with that overarching initiative, the RoboMET.3D™ is a specific asset of Center 1800 and is an automated serialsectioning system for destructive analysis of microstructure, which is called upon to provide direct customer support to 1800 and non-1800 customers. To that end, data collection, 3d reconstruction and analysis of typical and atypical microstructures have been pursued for the purposes of qualitative and quantitative characterization with a goal toward linking microstructural defects and/or microstructural features with mechanical response. Material systems examined in FY15 include precipitation hardened 17-4 steel, laser-welds of 304L stainless steel, thermal spray coatings of 304L and geological samples of sandstone.

  7. Coriocarcinoma con metástasis pulmonar

    Directory of Open Access Journals (Sweden)

    Vicia Sánchez Abalos

    2014-05-01

    Full Text Available Se presenta el caso clínico de una fémina de 44 años de edad, con 32 semanas de embarazo, la cual fuera ingresada en la Unidad de Cuidados Intensivos del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, por presentar insuficiencia respiratoria aguda como consecuencia de una sepsis. La paciente fue tratada con cefalosporina de tercera generación y ventilación mecánica no invasiva, pero se mantuvieron las características gasométricas de hipoxemia y una mala reacción terapéutica, por lo que se requirió instrumentación de las vías respiratorias y soporte hemodinámico, sin lograr regresión del cuadro clínico, lo cual condujo a un paro cardiorrespiratorio y, con ello, a la muerte. La necropsia mostró un coriocarcinoma del endometrio con metástasis pulmonar

  8. Model of unified gauge fields; Le modele des champs de jauge unifies

    Energy Technology Data Exchange (ETDEWEB)

    Leite Lopes, J. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)

    1998-04-01

    In this work, we discuss the physical ideas which represents the basis for the unified gauge field model. Despite of the difficulties that we presently have for embodying in a natural manner muons and hadrons in that model, we have the feeling that we are on the way which seems to lead to the construction of a theory in which the Maxwell electromagnetic field and the Fermi weak interaction field are manifestations of a unique subjacent physical entity - the unified gauge fields. (author) 22 refs., 6 figs.

  9. Operating plan for the Office of International Health Programs

    International Nuclear Information System (INIS)

    1996-01-01

    In this report unified ideas are presented about what the Office of International Health Programs does, what the individual contributions are, and how the organization connects to the Department of Energy. The planning efforts have focused on the office's three areas of responsibility: Europe, Japan, and the Marshall Islands. Common to each technical program area are issues related to the following: health of populations exposed to radiation incidents and the associated medical aspects of exposure; dose reconstruction; training; and public involvement. Each of the program areas, its customers, and primary customer interests are described

  10. LEP constraints on grand unified theories

    International Nuclear Information System (INIS)

    Sarkar, Utpal

    1993-01-01

    Recent developments on grand unified theories (GUTs) in the context of the LEP measurements of the coupling constants are reviewed. The three coupling constants at the electroweak scale have been measured at LEP quite precisely. One can allow these couplings to evolve with energy following the renormalization group equations for the various groups and find out whether all the coupling constants meet at any energy. It was pointed out that the minimal SU(5) grand unified theory fails to satisfy this test. However, various extensions of the theory are still allowed. These extensions include (i) supersymmetric SU(5) GUT, with some arbitrariness in the susy breaking scale arising from the threshold corrections, (ii) non-susy SU(5) GUTs with additional fermions as well as Higgs multiplets, which has masses of the order of TeV, and (iii) non-renormalizable effect of gravity with a fine tuned relation among the coupling constants at the unification energy. The LEP results also constrain GUTs with an intermediate symmetry breaking scale. By adjusting the intermediate symmetry breaking scale, one usually can have unification, but these theories get constrained. For example, the left-right symmetric theories coming from GUTs can be broken only at energies higher than about ∼10 10 GeV. This implies that if right handed gauge bosons are found at energies lower than this scale, then that will rule out the possibility of grand unification. Another recent interesting development on the subject, namely, low energy unification, is discussed in this context. All the coupling constants are unified at energies of the order of ∼10 8 GeV when they are embedded in an SU(15)GUT, with some particular symmetry breaking pattern. But even in this case the results of the intermediate symmetry breaking scale remain unchanged. (author). 16 refs., 3 figs

  11. Progress in switching technology for METS systems

    International Nuclear Information System (INIS)

    Honig, E.M.; Swannack, C.E.; Warren, R.W.; Whitaker, D.H.

    1977-01-01

    Three distinct sets of switching requirements have emerged from design optimization studies of large superconducting magnetic energy storage systems, such as the METS system to power the adiabatic plasma compression field in the proposed theta-pinch SFTR. Extremely low joule loss cryogenic disconnects are required between storage coils in the liquid helium environment to allow charging the coils in series over a prolonged time, then to isolate the coils for parallel fast discharging into the load. Another switch must break the current in the series charging loop and absorb the energy from the stray inductance. This action will allow the subsequent opening of the cryogenic disconnects under near zero current condition. The current now has been transferred to the many paralleled circuits, each containing a high current, high voltage interrupter. The opening and arc commutation of the interrupter starts the energy transfer into the load. The primary activities associated with cryogenic disconnect have been testing and development of contact materials, configurations, and closing forces for carrying 26 kA with a resistance less than 40 nΩ, and development of an actuating system that is both reliable and fast acting in a liquid helium environment. The charging loop switch will include a continuous duty switch and a vacuum interrupter. The continuous duty switch resistance can be an order of magnitude larger than that of the cryogenic disconnect because it does not present a refrigeration load. The HVDC interrupter must break 26 kA and withstand 60 kV during the energy transfer time of 700 μs. Testing in progress already has shown successful interruption using single vacuum interrupters up to 31 kA and 66 kV

  12. Cosmotopological relation for a unified field theory

    International Nuclear Information System (INIS)

    Bij, J. J. van der

    2007-01-01

    I present an argument, based on the topology of the universe, why there are three generations of fermions. The argument implies a preferred unified gauge group of SU(5), but with SO(10) representations of the fermions. The breaking pattern SU(5)→SU(3)xSU(2)xU(1) is preferred over the pattern SU(5)→SU(4)xU(1). On the basis of the argument one expects an asymmetry in the early universe microwave data, which might have been detected already

  13. General unifying features of controlled quantum phenomena

    International Nuclear Information System (INIS)

    Pechen, Alexander; Brif, Constantin; Wu, Rebing; Chakrabarti, Raj; Rabitz, Herschel

    2010-01-01

    Many proposals have been put forth for controlling quantum phenomena, including open-loop, adaptive feedback, and real-time feedback control. Each of these approaches has been viewed as operationally, and even physically, distinct from the others. This work shows that all such scenarios inherently share the same fundamental control features residing in the topology of the landscape relating the target physical observable to the applied controls. This unified foundation may provide a basis for development of hybrid control schemes that would combine the advantages of the existing approaches to achieve the best overall performance.

  14. Towards unifying inheritance and automatic program specialization

    DEFF Research Database (Denmark)

    Schultz, Ulrik Pagh

    2002-01-01

    and specialization of classes (inheritance) are considered different abstractions. We present a new programming language, Lapis, that unifies inheritance and program specialization at the conceptual, syntactic, and semantic levels. This paper presents the initial development of Lapis, which uses inheritance...... with covariant specialization to control the automatic application of program specialization to class members. Lapis integrates object-oriented concepts, block structure, and techniques from automatic program specialization to provide both a language where object-oriented designs can be e#ciently implemented...

  15. Leading gravitational corrections and a unified universe

    DEFF Research Database (Denmark)

    Codello, Alessandro; Jain, Rajeev Kumar

    2016-01-01

    Leading order gravitational corrections to the Einstein-Hilbert action can lead to a consistent picture of the universe by unifying the epochs of inflation and dark energy in a single framework. While the leading local correction induces an inflationary phase in the early universe, the leading...... nonlocal term leads to an accelerated expansion of the universe at the present epoch. We argue that both the leading UV and IR terms can be obtained within the framework of a covariant effective field theory of gravity. The perturbative gravitational corrections therefore provide a fundamental basis...

  16. TOWARDS A UNIFIED VIEW OF METAHEURISTICS

    Directory of Open Access Journals (Sweden)

    El-Ghazali Talbi

    2013-02-01

    Full Text Available This talk provides a complete background on metaheuristics and presents in a unified view the main design questions for all families of metaheuristics and clearly illustrates how to implement the algorithms under a software framework to reuse both the design and code. The key search components of metaheuristics are considered as a toolbox for: - Designing efficient metaheuristics (e.g. local search, tabu search, simulated annealing, evolutionary algorithms, particle swarm optimization, scatter search, ant colonies, bee colonies, artificial immune systems for optimization problems. - Designing efficient metaheuristics for multi-objective optimization problems. - Designing hybrid, parallel and distributed metaheuristics. - Implementing metaheuristics on sequential and parallel machines.

  17. Improvements on a Unified Dark Matter Model

    Directory of Open Access Journals (Sweden)

    Del Popolo A.

    2016-06-01

    Full Text Available We study, by means of a spherical collapse model, the effect of shear, rotation, and baryons on a generalized Chaplygin gas (gCg dominated universe. We show that shear, rotation, and the presence of baryons slow down the collapse compared to the simple spherical collapse model. The slowing down in the growth of density perturbation is able to solve the instability of the unified dark matter (UDM models described in previous papers (e.g. Sandvik et al. 2004 at the linear perturbation level, as also shown by a direct comparison of our model with previous results.

  18. NOAA Workforce Management Office

    Science.gov (United States)

    Management Fellows (PMFs) Program Coordination Office - Leadership Development Program (PCO-LDP) Employee (NRAP) Presidential Management Fellows (PMFs) Program Coordination Office - Leadership Development ) NOAA Leadership Seminar (NLS) NOAA Rotational Assignment Program (NRAP) Presidential Management Fellows

  19. HUD's Local Office Directory

    Data.gov (United States)

    Department of Housing and Urban Development — HUD is organized in 10 Regions. Each Region is managed by a Regional Administrator, who also oversees the Regional Office. Each Field Office within a Region is...

  20. Fermilab Education Office - Contacts

    Science.gov (United States)

    Search The Office of Education and Public Outreach: Contacts All telephone numbers require area code Presentations for Presenters 840-3094 Office of Education and Public Outreach Spencer Pasero spasero@fnal.gov Education Office 840-3076 Fermilab Friends for Science Education General Questions Susan Dahl sdahl@fnal.gov

  1. Fermilab Education Office - Physicists

    Science.gov (United States)

    on Education Server, but to take full advantage of all of this site's features, you should turn Custom Search Connect with the Fermilab Education Office! Facebook Fermilab Education Office Join these groups: Science Adventures Group Teacher Resource Center Group Twitter Fermilab Education Office For more

  2. Office Computers: Ergonomic Considerations.

    Science.gov (United States)

    Ganus, Susannah

    1984-01-01

    Each new report of the office automation market indicates technology is overrunning the office. The impacts of this technology are described and some ways to manage and physically "soften" the change to a computer-based office environment are suggested. (Author/MLW)

  3. Deja vu: The Unified Command Plan of the Future Revisited

    Science.gov (United States)

    2011-05-19

    Approved for Public Release; Distribution is Unlimited Déjà vu : The Unified Command Plan of the Future Revisited A Monograph by Lieutenant...DD-MM-YYYY) 19-05-2011 2. REPORT TYPE Monograph 3. DATES COVERED (From - To) JUL 2010 – MAY 2011 4. TITLE AND SUBTITLE Déjà vu : The Unified...i SCHOOL OF ADVANCED MILITARY STUDIES MONOGRAPH APPROVAL Lieutenant Colonel Edward Francis Martignetti Title of Monograph: Déjà vu : The Unified

  4. A unified view of "how allostery works".

    Science.gov (United States)

    Tsai, Chung-Jung; Nussinov, Ruth

    2014-02-01

    The question of how allostery works was posed almost 50 years ago. Since then it has been the focus of much effort. This is for two reasons: first, the intellectual curiosity of basic science and the desire to understand fundamental phenomena, and second, its vast practical importance. Allostery is at play in all processes in the living cell, and increasingly in drug discovery. Many models have been successfully formulated, and are able to describe allostery even in the absence of a detailed structural mechanism. However, conceptual schemes designed to qualitatively explain allosteric mechanisms usually lack a quantitative mathematical model, and are unable to link its thermodynamic and structural foundations. This hampers insight into oncogenic mutations in cancer progression and biased agonists' actions. Here, we describe how allostery works from three different standpoints: thermodynamics, free energy landscape of population shift, and structure; all with exactly the same allosteric descriptors. This results in a unified view which not only clarifies the elusive allosteric mechanism but also provides structural grasp of agonist-mediated signaling pathways, and guides allosteric drug discovery. Of note, the unified view reasons that allosteric coupling (or communication) does not determine the allosteric efficacy; however, a communication channel is what makes potential binding sites allosteric.

  5. DataSpread: Unifying Databases and Spreadsheets.

    Science.gov (United States)

    Bendre, Mangesh; Sun, Bofan; Zhang, Ding; Zhou, Xinyan; Chang, Kevin ChenChuan; Parameswaran, Aditya

    2015-08-01

    Spreadsheet software is often the tool of choice for ad-hoc tabular data management, processing, and visualization, especially on tiny data sets. On the other hand, relational database systems offer significant power, expressivity, and efficiency over spreadsheet software for data management, while lacking in the ease of use and ad-hoc analysis capabilities. We demonstrate DataSpread, a data exploration tool that holistically unifies databases and spreadsheets. It continues to offer a Microsoft Excel-based spreadsheet front-end, while in parallel managing all the data in a back-end database, specifically, PostgreSQL. DataSpread retains all the advantages of spreadsheets, including ease of use, ad-hoc analysis and visualization capabilities, and a schema-free nature, while also adding the advantages of traditional relational databases, such as scalability and the ability to use arbitrary SQL to import, filter, or join external or internal tables and have the results appear in the spreadsheet. DataSpread needs to reason about and reconcile differences in the notions of schema, addressing of cells and tuples, and the current "pane" (which exists in spreadsheets but not in traditional databases), and support data modifications at both the front-end and the back-end. Our demonstration will center on our first and early prototype of the DataSpread, and will give the attendees a sense for the enormous data exploration capabilities offered by unifying spreadsheets and databases.

  6. SO(10) supersymmetric grand unified theories

    Science.gov (United States)

    Dermisek, Radovan

    The origin of the fermion mass hierarchy is one of the most challenging problems in elementary particle physics. In the standard model fermion masses and mixing angles are free parameters. Supersymmetric grand unified theories provide a beautiful framework for physics beyond the standard model. In addition to gauge coupling unification these theories provide relations between quark and lepton masses within families, and with additional family symmetry the hierarchy between families can be generated. We present a predictive SO(10) supersymmetric grand unified model with D 3 x U(1) family symmetry. The hierarchy in fermion masses is generated by the family symmetry breaking D 3 x U(1) → ZN → nothing. This model fits the low energy data in the charged fermion sector quite well. We discuss the prediction of this model for the proton lifetime in light of recent SuperKamiokande results and present a clear picture of the allowed spectra of supersymmetric particles. Finally, the detailed discussion of the Yukawa coupling unification of the third generation particles is provided. We find a narrow region is consistent with t, b, tau Yukawa unification for mu > 0 (suggested by b → sgamma and the anomalous magnetic moment of the muon) with A0 ˜ -1.9m16, m10 ˜ 1.4m16, m16 ≳ 1200 GeV and mu, M1/2 ˜ 100--500 GeV. Demanding Yukawa unification thus makes definite predictions for Higgs and sparticle masses.

  7. Unifying hydrotropy under Gibbs phase rule.

    Science.gov (United States)

    Shimizu, Seishi; Matubayasi, Nobuyuki

    2017-09-13

    The task of elucidating the mechanism of solubility enhancement using hydrotropes has been hampered by the wide variety of phase behaviour that hydrotropes can exhibit, encompassing near-ideal aqueous solution, self-association, micelle formation, and micro-emulsions. Instead of taking a field guide or encyclopedic approach to classify hydrotropes into different molecular classes, we take a rational approach aiming at constructing a unified theory of hydrotropy based upon the first principles of statistical thermodynamics. Achieving this aim can be facilitated by the two key concepts: (1) the Gibbs phase rule as the basis of classifying the hydrotropes in terms of the degrees of freedom and the number of variables to modulate the solvation free energy; (2) the Kirkwood-Buff integrals to quantify the interactions between the species and their relative contributions to the process of solubilization. We demonstrate that the application of the two key concepts can in principle be used to distinguish the different molecular scenarios at work under apparently similar solubility curves observed from experiments. In addition, a generalization of our previous approach to solutes beyond dilution reveals the unified mechanism of hydrotropy, driven by a strong solute-hydrotrope interaction which overcomes the apparent per-hydrotrope inefficiency due to hydrotrope self-clustering.

  8. A unified dynamics for micro and macrosystems

    International Nuclear Information System (INIS)

    Ghirardi, G.C.; Rimini, A.; Weber, T.

    1985-12-01

    An explicit model allowing a unified description of micro and macrosystems is exhibited. Firstly, a modified quantum dynamics for the description of macroobjects is constructed and it is shown that it forbids the occurrence of linear superpositions of states localized in far away spatial regions and induces an evolution agreeing with classical mechanics. This dynamics also allows a description of the evolution in terms of trajectories. To set up a unified description of all physical phenomena, a modification of the dynamics, with respect to the standard Hamiltonian one, is then postulated also for microscopic systems. It is shown that one can consistently deduce from it the previously considered dynamics for the centre of mass of macroscopic systems. Choosing in an appropriate way the parameters of the so obtained model one can show that the standard quantum theory for microobjects, the quantum mechanical wave packet reduction with fixed pointer positions, and the classical behaviour for macroobjects can be all derived in a consistent way. Moreover, in the case of a macroscopic system one can obtain, by means of appropriate approximations, a description of the evolution in terms of a phase-space density distribution obeying a Fokker-Planck diffusion equation. (author)

  9. Group theory for unified model building

    International Nuclear Information System (INIS)

    Slansky, R.

    1981-01-01

    The results gathered here on simple Lie algebras have been selected with attention to the needs of unified model builders who study Yang-Mills theories based on simple, local-symmetry groups that contain as a subgroup the SUsup(w) 2 x Usup(w) 1 x SUsup(c) 3 symmetry of the standard theory of electromagnetic, weak, and strong interactions. The major topics include, after a brief review of the standard model and its unification into a simple group, the use of Dynkin diagrams to analyze the structure of the group generators and to keep track of the weights (quantum numbers) of the representation vectors; an analysis of the subgroup structure of simple groups, including explicit coordinatizations of the projections in weight space; lists of representations, tensor products and branching rules for a number of simple groups; and other details about groups and their representations that are often helpful for surveying unified models, including vector-coupling coefficient calculations. Tabulations of representations, tensor products, and branching rules for E 6 , SO 10 , SU 6 , F 4 , SO 9 , SO 5 , SO 8 , SO 7 , SU 4 , E 7 , E 8 , SU 8 , SO 14 , SO 18 , SO 22 , and for completeness, SU 3 are included. (These tables may have other applications.) Group-theoretical techniques for analyzing symmetry breaking are described in detail and many examples are reviewed, including explicit parameterizations of mass matrices. (orig.)

  10. A Unified Theoretical Framework for Cognitive Sequencing.

    Science.gov (United States)

    Savalia, Tejas; Shukla, Anuj; Bapi, Raju S

    2016-01-01

    The capacity to sequence information is central to human performance. Sequencing ability forms the foundation stone for higher order cognition related to language and goal-directed planning. Information related to the order of items, their timing, chunking and hierarchical organization are important aspects in sequencing. Past research on sequencing has emphasized two distinct and independent dichotomies: implicit vs. explicit and goal-directed vs. habits. We propose a theoretical framework unifying these two streams. Our proposal relies on brain's ability to implicitly extract statistical regularities from the stream of stimuli and with attentional engagement organizing sequences explicitly and hierarchically. Similarly, sequences that need to be assembled purposively to accomplish a goal require engagement of attentional processes. With repetition, these goal-directed plans become habits with concomitant disengagement of attention. Thus, attention and awareness play a crucial role in the implicit-to-explicit transition as well as in how goal-directed plans become automatic habits. Cortico-subcortical loops basal ganglia-frontal cortex and hippocampus-frontal cortex loops mediate the transition process. We show how the computational principles of model-free and model-based learning paradigms, along with a pivotal role for attention and awareness, offer a unifying framework for these two dichotomies. Based on this framework, we make testable predictions related to the potential influence of response-to-stimulus interval (RSI) on developing awareness in implicit learning tasks.

  11. A Unified Theoretical Framework for Cognitive Sequencing

    Directory of Open Access Journals (Sweden)

    Tejas Savalia

    2016-11-01

    Full Text Available The capacity to sequence information is central to human performance. Sequencing ability forms the foundation stone for higher order cognition related to language and goal-directed planning. Information related to the order of items, their timing, chunking and hierarchical organization are important aspects in sequencing. Past research on sequencing has emphasized two distinct and independent dichotomies: implicit versus explicit and goal-directed versus habits. We propose a theoretical framework unifying these two streams. Our proposal relies on brain's ability to implicitly extract statistical regularities from the stream of stimuli and with attentional engagement organizing sequences explicitly and hierarchically. Similarly, sequences that need to be assembled purposively to accomplish a goal require engagement of attentional processes. With repetition, these goal-directed plans become habits with concomitant disengagement of attention. Thus attention and awareness play a crucial role in the implicit-to-explicit transition as well as in how goal-directed plans become automatic habits. Cortico-subcortical loops ─ basal ganglia-frontal cortex and hippocampus-frontal cortex loops ─ mediate the transition process. We show how the computational principles of model-free and model-based learning paradigms, along with a pivotal role for attention and awareness, offer a unifying framework for these two dichotomies. Based on this framework, we make testable predictions related to the potential influence of response-to-stimulus interval (RSI on developing awareness in implicit learning tasks.

  12. Aspects of extra dimensional supersymmetric unified theories

    International Nuclear Information System (INIS)

    Fichet, S.

    2011-09-01

    The purpose of this work is to investigate Grand Unified Theories (GUTs) and to make the link with passed and upcoming experiments. The structure of this thesis is as follows. In the first chapter, we will briefly review the sequence of arguments leading to the Higgs mechanism, then to the different concepts underlying physics beyond the Standard Model, and to the paradigm of extra dimensional supersymmetric grand unified theories. At each level of the argumentation, we will mention the different solutions available. The second chapter introduces more formally supersymmetry and extra dimensions, focusing in particular on the aspects of symmetry breaking. Then, in the third chapter, we present in details the two frameworks of extra dimensional theories in which we worked, called supersymmetric gauge-Higgs unification (GHU) and holographic grand unification (HGU) as well as the developments and modifications we brought to them. The fourth chapter is devoted to the low energy viability of the GHU framework, as well as its phenomenological implications. The fifth chapter presents a more generic study of the property of GUT-scale degenerate Higgs mass matrix, common to both frameworks. Finally, the sixth chapter is devoted to the viability and phenomenological implications of the HGU framework, with special emphasis on lepton flavour violation. This quantitative study takes properly into account effects of matrix anarchy, as well as exact flavour observables. The results obtained should generalize, at least qualitatively, to any other model with similar localization and supersymmetry breaking features

  13. Office 2013 simplified

    CERN Document Server

    Marmel, Elaine

    2013-01-01

    A basic introduction to learn Office 2013 quickly, easily, and in full color Office 2013 has new features and tools to master, and whether you're upgrading from an earlier version or using the Office applications for the first time, you'll appreciate this simplified approach. Offering a clear, visual style of learning, this book provides you with concise, step-by-step instructions and full-color screen shots that walk you through the applications in the Microsoft Office 2013 suite: Word, Excel, PowerPoint, Outlook, and Publisher.Shows you how to tackle dozens of Office 2013

  14. Office 2013 for dummies

    CERN Document Server

    Wang, Wallace

    2013-01-01

    Office 2013 For Dummies is the key to your brand new Office! Packed with straightforward, friendly instruction, this update to one of the bestselling Office books of all time gets you thoroughly up to speed and helps you learn how to take full advantage of the new features in Office 2013. After coverage of the fundamentals, you'll discover how to spice up your Word documents, edit Excel spreadsheets and create formulas, add pizazz to your PowerPoint presentation, and much more.Helps you harness the power of all five Office 2013 applications: Word, Excel, PowerPoint,

  15. MetRxn: a knowledgebase of metabolites and reactions spanning metabolic models and databases

    Directory of Open Access Journals (Sweden)

    Kumar Akhil

    2012-01-01

    Full Text Available Abstract Background Increasingly, metabolite and reaction information is organized in the form of genome-scale metabolic reconstructions that describe the reaction stoichiometry, directionality, and gene to protein to reaction associations. A key bottleneck in the pace of reconstruction of new, high-quality metabolic models is the inability to directly make use of metabolite/reaction information from biological databases or other models due to incompatibilities in content representation (i.e., metabolites with multiple names across databases and models, stoichiometric errors such as elemental or charge imbalances, and incomplete atomistic detail (e.g., use of generic R-group or non-explicit specification of stereo-specificity. Description MetRxn is a knowledgebase that includes standardized metabolite and reaction descriptions by integrating information from BRENDA, KEGG, MetaCyc, Reactome.org and 44 metabolic models into a single unified data set. All metabolite entries have matched synonyms, resolved protonation states, and are linked to unique structures. All reaction entries are elementally and charge balanced. This is accomplished through the use of a workflow of lexicographic, phonetic, and structural comparison algorithms. MetRxn allows for the download of standardized versions of existing genome-scale metabolic models and the use of metabolic information for the rapid reconstruction of new ones. Conclusions The standardization in description allows for the direct comparison of the metabolite and reaction content between metabolic models and databases and the exhaustive prospecting of pathways for biotechnological production. This ever-growing dataset currently consists of over 76,000 metabolites participating in more than 72,000 reactions (including unresolved entries. MetRxn is hosted on a web-based platform that uses relational database models (MySQL.

  16. Research progress in c-Met and hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    WANG Changqing

    2015-06-01

    Full Text Available c-Met plays a pivotal role in the development and progression of hepatocellular carcinoma (HCC, which can lead to proliferation, survival, cytoskeleton reorganization, separation and diffusion, and angiogenesis of tumor cells. Moreover, c-Met is an important prognostic factor for HCC. In HCC, c-Met acts as an activator of a series of signaling pathways, including PI3K/AKT/mTOR, ERK/MAPK, and Rac-Pak. In recent years, it has been reported that small-molecule kinase inhibitors can abolish phosphorylation at the intracellular carboxyl terminal of c-Met, and then inhibit the recruitment of signal convertors and downstream signaling pathways, which finally achieve anti-tumor activities. Based on the carcinogenic activity of c-Met in HCC, this paper points out that selective inhibitors of c-Met hold promise for targeted therapies for HCC.

  17. Design and Implementation of Image Research for the Columbia Mets

    Science.gov (United States)

    1992-01-01

    the other hand, developed an unusual camaraderie through identifying with their underdog Mets." (7) Teams are finding good public relations programs do...supports the club. Question 24 was designed to measure brand loyalty by respondents to Mets sponsors versus non-Mets sponsors. Finally, question 27...be done to attract crowds. Especially with a brand new stadium. The Carolinas, in my opinion, are big minor league baseball states. Let’s get people

  18. Effective implementation of novel MET pharmacodynamic assays in translational studies.

    Science.gov (United States)

    Srivastava, Apurva K; Navas, Tony; Herrick, William G; Hollingshead, Melinda G; Bottaro, Donald P; Doroshow, James H; Parchment, Ralph E

    2017-01-01

    MET tyrosine kinase (TK) dysregulation is significantly implicated in many types of cancer. Despite over 20 years of drug development to target MET in cancers, a pure anti-MET therapeutic has not yet received market approval. The failure of two recently concluded phase III trials point to a major weakness in biomarker strategies to identify patients who will benefit most from MET therapies. The capability to interrogate oncogenic mutations in MET via circulating tumor DNA (ctDNA) provides an important advancement in identification and stratification of patients for MET therapy. However, a wide range in type and frequency of these mutations suggest there is a need to carefully link these mutations to MET dysregulation, at least in proof-of-concept studies. In this review, we elaborate how we can utilize recently developed and validated pharmacodynamic biomarkers of MET not only to show target engagement, but more importantly to quantitatively measure MET dysregulation in tumor tissues. The MET assay endpoints provide evidence of both canonical and non-canonical MET signaling, can be used as "effect markers" to define biologically effective doses (BEDs) for molecularly targeted drugs, confirm mechanism-of-action in testing combination of drugs, and establish whether a diagnostic test is reporting MET dysregulation. We have established standard operating procedures for tumor biopsy collections to control pre-analytical variables that have produced valid results in proof-of-concept studies. The reagents and procedures are made available to the research community for potential implementation on multiple platforms such as ELISA, quantitative immunofluorescence assay (qIFA), and immuno-MRM assays.

  19. Targeting MET Amplification as a New Oncogenic Driver

    Energy Technology Data Exchange (ETDEWEB)

    Kawakami, Hisato [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Okamoto, Isamu, E-mail: okamotoi@kokyu.med.kyushu-u.ac.jp [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Center for Clinical and Translational Research, Kyushu University Hospital, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582 (Japan); Okamoto, Wataru [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Division of Transrlational Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577 (Japan); Tanizaki, Junko [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, HIM223, 450 Brookline Avenue, Boston, MA 02215 (United States); Nakagawa, Kazuhiko [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Nishio, Kazuto [Department of Genome Biology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan)

    2014-07-22

    Certain genetically defined cancers are dependent on a single overactive oncogene for their proliferation and survival, a phenomenon known as “oncogene addiction”. A new generation of drugs that selectively target such “driver oncogenes” manifests a clinical efficacy greater than that of conventional chemotherapy in appropriate genetically defined patients. MET is a proto-oncogene that encodes a receptor tyrosine kinase, and aberrant activation of MET signaling occurs in a subset of advanced cancers as result of various genetic alterations including gene amplification, polysomy, and gene mutation. Our preclinical studies have shown that inhibition of MET signaling either with the small-molecule MET inhibitor crizotinib or by RNA interference targeted to MET mRNA resulted in marked antitumor effects in cancer cell lines with MET amplification both in vitro and in vivo. Furthermore, patients with non-small cell lung cancer or gastric cancer positive for MET amplification have shown a pronounced clinical response to crizotinib. Accumulating preclinical and clinical evidence thus suggests that MET amplification is an “oncogenic driver” and therefore a valid target for treatment. However, the prevalence of MET amplification has not been fully determined, possibly in part because of the difficulty in evaluating gene amplification. In this review, we provide a rationale for targeting this genetic alteration in cancer therapy.

  20. Targeting MET Amplification as a New Oncogenic Driver

    International Nuclear Information System (INIS)

    Kawakami, Hisato; Okamoto, Isamu; Okamoto, Wataru; Tanizaki, Junko; Nakagawa, Kazuhiko; Nishio, Kazuto

    2014-01-01

    Certain genetically defined cancers are dependent on a single overactive oncogene for their proliferation and survival, a phenomenon known as “oncogene addiction”. A new generation of drugs that selectively target such “driver oncogenes” manifests a clinical efficacy greater than that of conventional chemotherapy in appropriate genetically defined patients. MET is a proto-oncogene that encodes a receptor tyrosine kinase, and aberrant activation of MET signaling occurs in a subset of advanced cancers as result of various genetic alterations including gene amplification, polysomy, and gene mutation. Our preclinical studies have shown that inhibition of MET signaling either with the small-molecule MET inhibitor crizotinib or by RNA interference targeted to MET mRNA resulted in marked antitumor effects in cancer cell lines with MET amplification both in vitro and in vivo. Furthermore, patients with non-small cell lung cancer or gastric cancer positive for MET amplification have shown a pronounced clinical response to crizotinib. Accumulating preclinical and clinical evidence thus suggests that MET amplification is an “oncogenic driver” and therefore a valid target for treatment. However, the prevalence of MET amplification has not been fully determined, possibly in part because of the difficulty in evaluating gene amplification. In this review, we provide a rationale for targeting this genetic alteration in cancer therapy

  1. Preproghrelin Leu72Met polymorphism in obese Korean children.

    Science.gov (United States)

    Jo, Dae-Sun; Kim, Se-Lim; Kim, Sun-Young; Hwang, Pyoung Han; Lee, Kee-Hyoung; Lee, Dae-Yeol

    2005-11-01

    Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.

  2. Mars MetNet Mission Pressure and Humidity Devices

    Science.gov (United States)

    Haukka, H.; Harri, A.-M.; Schmidt, W.; Genzer, M.; Polkko, J.; Kemppinen, O.; Leinonen, J.

    2012-09-01

    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). MetBaro and MetHumi are part of the scientific payload of the MNL. Main scientific goal of both devices is to measure the meteorological phenomena (pressure and humidity) of the Martian atmosphere and complement the previous Mars mission atmospheric measurements (Viking and Phoenix) for better understanding of the Martian atmospheric conditions.

  3. Hilltop supernatural inflation and SUSY unified models

    Science.gov (United States)

    Kohri, Kazunori; Lim, C. S.; Lin, Chia-Min; Mimura, Yukihiro

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is ns = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) the role of inflaton.

  4. Hilltop supernatural inflation and SUSY unified models

    Energy Technology Data Exchange (ETDEWEB)

    Kohri, Kazunori [Cosmophysics Group, Theory Center, IPNS KEK, and The Graduate University for Advanced Studies (Sokendai), 1-1 Oho, Tsukuba, 305-0801 (Japan); Lim, C.S. [Department of Mathematics, Tokyo Woman' s Christian University, Tokyo, 167-8585 (Japan); Lin, Chia-Min [Department of Physics, Chuo University, Bunkyo-ku, Tokyo, 112 (Japan); Mimura, Yukihiro, E-mail: kohri@post.kek.jp, E-mail: lim@lab.twcu.ac.jp, E-mail: lin@chuo-u.ac.jp, E-mail: mimura@hep1.phys.ntu.edu.tw [Department of Physics, National Taiwan University, Taipei, 10617 Taiwan (China)

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is n{sub s} = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) the role of inflaton.

  5. Unifying flipped SU(5) in five dimensions

    International Nuclear Information System (INIS)

    Barr, S.M.; Dorsner, Ilja

    2002-01-01

    It is shown that embedding a four-dimensional flipped SU(5) model in a five-dimensional SO(10) model preserves the best features of both flipped SU(5) and SO(10). The missing partner mechanism, which naturally achieves both doublet-triplet splitting and suppression of d=5 proton decay operators, is realized as in flipped SU(5), while the gauge couplings are unified as in SO(10). The masses of down quarks and charged leptons, which are independent in flipped SU(5), are related by the SO(10). Distinctive patterns of quark and lepton masses can result. The gaugino mass M 1 is independent of M 3 and M 2 , which are predicted to be equal

  6. Covariant extensions and the nonsymmetric unified field

    International Nuclear Information System (INIS)

    Borchsenius, K.

    1976-01-01

    The problem of generally covariant extension of Lorentz invariant field equations, by means of covariant derivatives extracted from the nonsymmetric unified field, is considered. It is shown that the contracted curvature tensor can be expressed in terms of a covariant gauge derivative which contains the gauge derivative corresponding to minimal coupling, if the universal constant p, characterizing the nonsymmetric theory, is fixed in terms of Planck's constant and the elementary quantum of charge. By this choice the spinor representation of the linear connection becomes closely related to the spinor affinity used by Infeld and Van Der Waerden (Sitzungsber. Preuss. Akad. Wiss. Phys. Math. Kl.; 9:380 (1933)) in their generally covariant formulation of Dirac's equation. (author)

  7. SUGERE - a unified system for waste management

    International Nuclear Information System (INIS)

    Silva, Eliane Magalhaes Pereira da; Vasconcelos, Vanderley de; Senne Junior, Murillo; Jordao, Elizabete

    2005-01-01

    Generation and disposal of wastes has been responsible for many economical, ecological and public health problems. In order to manage hazardous wastes in an environment friendly manner, many technical and administrative procedures should be implemented, including prevention, control of generation, and final disposal. A software named SUGERE - a unified system for waste management - is being developed. It is an easy to use tool that integrates all the steps involved in hazardous and radioactive waste management. This system is intended to help generators, transporters and owners of treatment, storage and disposal facilities to manage hazardous and radioactive wastes, by assuring compliance with environmental laws and consumer requirements. This paper presents the current status of the SUGERE software, developed using Borland Delphi package. The nuclear industry is used as a reference for developing this work. (author)

  8. UniPOPS: Unified data reduction suite

    Science.gov (United States)

    Maddalena, Ronald J.; Garwood, Robert W.; Salter, Christopher J.; Stobie, Elizabeth B.; Cram, Thomas R.; Morgan, Lorrie; Vance, Bob; Hudson, Jerome

    2015-03-01

    UniPOPS, a suite of programs and utilities developed at the National Radio Astronomy Observatory (NRAO), reduced data from the observatory's single-dish telescopes: the Tucson 12-m, the Green Bank 140-ft, and archived data from the Green Bank 300-ft. The primary reduction programs, 'line' (for spectral-line reduction) and 'condar' (for continuum reduction), used the People-Oriented Parsing Service (POPS) as the command line interpreter. UniPOPS unified previous analysis packages and provided new capabilities; development of UniPOPS continued within the NRAO until 2004 when the 12-m was turned over to the Arizona Radio Observatory (ARO). The submitted code is version 3.5 from 2004, the last supported by the NRAO.

  9. A unified grand tour of theoretical physics

    CERN Document Server

    Lawrie, Ian D

    2013-01-01

    A Unified Grand Tour of Theoretical Physics invites its readers to a guided exploration of the theoretical ideas that shape our contemporary understanding of the physical world at the fundamental level. Its central themes, comprising space-time geometry and the general relativistic account of gravity, quantum field theory and the gauge theories of fundamental forces, and statistical mechanics and the theory of phase transitions, are developed in explicit mathematical detail, with an emphasis on conceptual understanding. Straightforward treatments of the standard models of particle physics and cosmology are supplemented with introductory accounts of more speculative theories, including supersymmetry and string theory. This third edition of the Tour includes a new chapter on quantum gravity, focusing on the approach known as Loop Quantum Gravity, while new sections provide extended discussions of topics that have become prominent in recent years, such as the Higgs boson, massive neutrinos, cosmological perturba...

  10. A Unifying Theory of Biological Function.

    Science.gov (United States)

    van Hateren, J H

    2017-01-01

    A new theory that naturalizes biological function is explained and compared with earlier etiological and causal role theories. Etiological (or selected effects) theories explain functions from how they are caused over their evolutionary history. Causal role theories analyze how functional mechanisms serve the current capacities of their containing system. The new proposal unifies the key notions of both kinds of theories, but goes beyond them by explaining how functions in an organism can exist as factors with autonomous causal efficacy. The goal-directedness and normativity of functions exist in this strict sense as well. The theory depends on an internal physiological or neural process that mimics an organism's fitness, and modulates the organism's variability accordingly. The structure of the internal process can be subdivided into subprocesses that monitor specific functions in an organism. The theory matches well with each intuition on a previously published list of intuited ideas about biological functions, including intuitions that have posed difficulties for other theories.

  11. Hilltop supernatural inflation and SUSY unified models

    International Nuclear Information System (INIS)

    Kohri, Kazunori; Lim, C.S.; Lin, Chia-Min; Mimura, Yukihiro

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is n s = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) the role of inflaton

  12. Centrally managed unified shared virtual address space

    Science.gov (United States)

    Wilkes, John

    2018-02-13

    Systems, apparatuses, and methods for managing a unified shared virtual address space. A host may execute system software and manage a plurality of nodes coupled to the host. The host may send work tasks to the nodes, and for each node, the host may externally manage the node's view of the system's virtual address space. Each node may have a central processing unit (CPU) style memory management unit (MMU) with an internal translation lookaside buffer (TLB). In one embodiment, the host may be coupled to a given node via an input/output memory management unit (IOMMU) interface, where the IOMMU frontend interface shares the TLB with the given node's MMU. In another embodiment, the host may control the given node's view of virtual address space via memory-mapped control registers.

  13. Cosmological implications of grand unified theories

    International Nuclear Information System (INIS)

    Nanopoulos, D.V.

    1982-01-01

    These lectures, mainly devoted to the cosmological implications of GUTs, also include the essential ingredients of GUTs and some of their important applications to particle physics. Section 1 contains some basic points concerning the structure of the standard strong and electroweak interactions prior to grand unification. A detailed expose of GUTs is attempted in sect. 2, including their basci principles and their consequences for particle physics. The minimal, simplest GUT, SU 5 is analysed in some detail and it will be used throughout these lectures as the GUT prototype. Finally, sect. 3 contains the most important cosmological implications of GUTs, including baryon number generation in the early Universe (in rather lengthy detail), dissipative processes in the very early Universe, grand unified monopoles, etc. (orig./HSI)

  14. OPC from data access to unified architecture

    CERN Document Server

    Lange, Jurgen; Burke, Thomas J

    2010-01-01

    OPC stands for Openness, Productivity, and Collaboration, symbolizing the new possibilities opening up in automation technology. The main objective of the new OPC generation Unified Architecture is to facilitate global interoperability and to define an information and data-exchange mechanism that is service oriented, multivendor, and cross-platform capable – from the field device on the shop floor to the ERP system on the factory level. This book includes information on: - the birth, objectives, and fundamentals of OPC and OPC UA, - the technical specifications that currently exist and those that are in preparation, - the procedures for designing and implementing components, - a transparent presentation of the technology through application possibilities and examples, and - the outlook for the future of OPC and OPC UA. Important perspectives and updates in this new edition include - the new era and the exciting application possibilities developing with OPC UA, - the new OPC UA specifications, - the devel...

  15. Introduction to Grand Unified Theories. 12

    International Nuclear Information System (INIS)

    Wali, K.C.

    1989-01-01

    This chapter presents an introduction into Grand Unified Theories. After a discussion of the general features to be expected in any such theory, and of the motivations for them, a detailed presentation of SU(5) theory is given. The group structures, particle multiplets, gauge and Higgs bosons are explained. The two stages of spontaneous symmetry breaking via the Higgs model, are calculated individually and in combination. Fermion mass matrices and relations between quark and lepton masses are derived. predictions of SU(5) theory, calculated using renormalization group methods, are derived. The chapter ends with discussions that bring together particle physics and cosmology, including the baryon asymmetry problem, phase transitions in the very early universe, and singularities like domain walls, vortex lines and monopoles. (author). 9 refs.; 4 figs.; 5 tabs

  16. On the History of Unified Field Theories

    Directory of Open Access Journals (Sweden)

    Goenner Hubert F.M.

    2004-01-01

    Full Text Available This article is intended to give a review of the history of the classical aspects of unified field theories in the 20th century. It includes brief technical descriptions of the theories suggested, short biographical notes concerning the scientists involved, and an extensive bibliography. The present first installment covers the time span between 1914 and 1933, i.e., when Einstein was living and working in Berlin - with occasional digressions into other periods. Thus, the main theme is the unification of the electromagnetic and gravitational fields augmented by short-lived attempts to include the matter field described by Schrödinger's or Dirac's equations. While my focus lies on the conceptual development of the field, by also paying attention to the interaction of various schools of mathematicians with the research done by physicists, some prosopocraphical remarks are included.

  17. Supersymmetric grand unified theories and cosmology

    International Nuclear Information System (INIS)

    Lazarides, G.; Shafi, Q.

    1983-01-01

    By examining the behavior of supersymmetric grand unified theories (GUT's) in the very early universe we find two classes of realistic models. In one of them supersymmetry is broken at or near superheavy GUT scale. The cosmological implications of such models are expected to be similar to those of nonsupersymmetric GUT's. In the second class of models, the superheavy GUT scale is related to the supersymmetry-breaking scale in the manner of Witten. Two types of cosmological scenarios appear possible in this case, either with or without an intermediate (new) inflationary phase. They can be experimentally distinguished, since the former predicts an absence and the latter an observable number density of superheavy monopoles. A mechanism for generating baryon asymmetry in such models is pointed out

  18. A unified approach to the Darwin approximation

    International Nuclear Information System (INIS)

    Krause, Todd B.; Apte, A.; Morrison, P. J.

    2007-01-01

    There are two basic approaches to the Darwin approximation. The first involves solving the Maxwell equations in Coulomb gauge and then approximating the vector potential to remove retardation effects. The second approach approximates the Coulomb gauge equations themselves, then solves these exactly for the vector potential. There is no a priori reason that these should result in the same approximation. Here, the equivalence of these two approaches is investigated and a unified framework is provided in which to view the Darwin approximation. Darwin's original treatment is variational in nature, but subsequent applications of his ideas in the context of Vlasov's theory are not. We present here action principles for the Darwin approximation in the Vlasov context, and this serves as a consistency check on the use of the approximation in this setting

  19. New ideas about unified field theory

    International Nuclear Information System (INIS)

    Gleiser, M.

    1986-01-01

    An outline of the physical concepts evolution is given from the ancient philosophers to the present time. With qualitative explanations about the meaning of the theories that is the milestones of these concepts evolution, it mentions the ideas which lead the studies to the conception of a unified field theory. Chronologically, it has brief information about the ideas of Laplace (mechanical determinism), Maxwell (the field concept), Einsten (the space-time structure), Heisenberg and Schroedinger (the quantum mechanics), Dirac (the relativistic quantum and the antiparticles), Gell-Mann (the quarks), Weinberg-Salam (Weak interactions and eletromagnetic unification), H. Georgi and S. Glashon (strong interactions plus Weinberg-Salam), Kaluza-Klein (a fifth space-time coordinate), and Zumino-Weiss (supersymmetry and supergravity). (G.D.F.) [pt

  20. Preface to a GUT (Grand Unified Theory)

    International Nuclear Information System (INIS)

    Honig, W.

    1982-01-01

    A Grand Unified Theory (GUT) is proposed exhibiting relativistic invariance and based on a physical model for vacuum space consisting of the superposition of oppositely charged continuous fluids. Models for the photon, electron, neutrino, proton, etc., consist of separate unique variations in the relative densities of the fluids and their flow patterns. This GUT is also based on the use of transfinite axiomatic number forms and on a concept of metrical relativity which hopefully reconciles the many logical dichotomies in and between Special Relativity and Quantum Mechanics. These ideas result in a number of experimental proposals and predicted results which appear to be underivable from present paradigms, first among which is a physical model for the hidden variable of Quantum Mechanics. It is on these features that attention should rest. (Auth.)

  1. Higgsless grand unified theory breaking and trinification

    International Nuclear Information System (INIS)

    Carone, Christopher D.; Conroy, Justin M.

    2004-01-01

    Boundary conditions on an extra dimensional interval can be chosen to break bulk gauge symmetries and to reduce the rank of the gauge group. We consider this mechanism in models with gauge trinification. We determine the boundary conditions necessary to break the trinified gauge group directly down to that of the standard model. Working in an effective theory for the gauge-symmetry-breaking parameters on a boundary, we examine the limit in which the grand-unified theory-breaking-sector is Higgsless and show how one may obtain the low-energy particle content of the minimal supersymmetric standard model. We find that gauge unification is preserved in this scenario, and that the differential gauge coupling running is logarithmic above the scale of compactification. We compare the phenomenology of our model to that of four dimensional 'trinified' theories

  2. Grand unified models including extra Z bosons

    International Nuclear Information System (INIS)

    Li Tiezhong

    1989-01-01

    The grand unified theories (GUT) of the simple Lie groups including extra Z bosons are discussed. Under authors's hypothesis there are only SU 5+m SO 6+4n and E 6 groups. The general discussion of SU 5+m is given, then the SU 6 and SU 7 are considered. In SU 6 the 15+6 * +6 * fermion representations are used, which are not same as others in fermion content, Yukawa coupling and broken scales. A conception of clans of particles, which are not families, is suggested. These clans consist of extra Z bosons and the corresponding fermions of the scale. The all of fermions in the clans are down quarks except for the standard model which consists of Z bosons and 15 fermions, therefore, the spectrum of the hadrons which are composed of these down quarks are different from hadrons at present

  3. Centrally managed unified shared virtual address space

    Energy Technology Data Exchange (ETDEWEB)

    Wilkes, John

    2018-02-13

    Systems, apparatuses, and methods for managing a unified shared virtual address space. A host may execute system software and manage a plurality of nodes coupled to the host. The host may send work tasks to the nodes, and for each node, the host may externally manage the node's view of the system's virtual address space. Each node may have a central processing unit (CPU) style memory management unit (MMU) with an internal translation lookaside buffer (TLB). In one embodiment, the host may be coupled to a given node via an input/output memory management unit (IOMMU) interface, where the IOMMU frontend interface shares the TLB with the given node's MMU. In another embodiment, the host may control the given node's view of virtual address space via memory-mapped control registers.

  4. Alternative Fuels Data Center: Mesa Unified School District Reaps Economic

    Science.gov (United States)

    and Environmental Benefits with Propane Buses Mesa Unified School District Reaps Economic and School District Reaps Economic and Environmental Benefits with Propane Buses on Facebook Tweet about Alternative Fuels Data Center: Mesa Unified School District Reaps Economic and Environmental Benefits with

  5. Unified SU(4) color models in ten dimensions

    International Nuclear Information System (INIS)

    Hanlon, B.E.; Joshi, G.C.

    1992-01-01

    Some aspects of constructing unified models with SU(4) as the color group via a unifying group defined in ten dimensions are examined. Four dimensional theories are recovered using the Coset Space Dimensional Reduction scheme. Candidate models are considered in order to highlight some of the difficulties in constructing realistic four dimensional theories. 30 refs

  6. MET Expression in Primary and Metastatic Clear Cell Renal Cell Carcinoma: Implications of Correlative Biomarker Assessment to MET Pathway Inhibitors

    Directory of Open Access Journals (Sweden)

    Brian Shuch

    2015-01-01

    Full Text Available Aims. Inhibitors of the MET pathway hold promise in the treatment for metastatic kidney cancer. Assessment of predictive biomarkers may be necessary for appropriate patient selection. Understanding MET expression in metastases and the correlation to the primary site is important, as distant tissue is not always available. Methods and Results. MET immunofluorescence was performed using automated quantitative analysis and a tissue microarray containing matched nephrectomy and distant metastatic sites from 34 patients with clear cell renal cell carcinoma. Correlations between MET expressions in matched primary and metastatic sites and the extent of heterogeneity were calculated. The mean expression of MET was not significantly different between primary tumors when compared to metastases (P=0.1. MET expression weakly correlated between primary and matched metastatic sites (R=0.5 and a number of cases exhibited very high levels of discordance between these tumors. Heterogeneity within nephrectomy specimens compared to the paired metastatic tissues was not significantly different (P=0.39. Conclusions. We found that MET expression is not significantly different in primary tumors than metastatic sites and only weakly correlates between matched sites. Moderate concordance of MET expression and significant expression heterogeneity may be a barrier to the development of predictive biomarkers using MET targeting agents.

  7. A Unified Scaling Law in Spiral Galaxies.

    Science.gov (United States)

    Koda; Sofue; Wada

    2000-03-01

    We investigate the origin of a unified scaling relation in spiral galaxies. Observed spiral galaxies are spread on a plane in the three-dimensional logarithmic space of luminosity L, radius R, and rotation velocity V. The plane is expressed as L~&parl0;VR&parr0;alpha in the I passband, where alpha is a constant. On the plane, observed galaxies are distributed in an elongated region which looks like the shape of a surfboard. The well-known scaling relations L-V (Tully-Fisher [TF] relation), V-R (also the TF relation), and R-L (Freeman's law) can be understood as oblique projections of the surfboard-like plane into two-dimensional spaces. This unified interpretation of the known scaling relations should be a clue to understand the physical origin of all the relations consistently. Furthermore, this interpretation can also explain why previous studies could not find any correlation between TF residuals and radius. In order to clarify the origin of this plane, we simulate formation and evolution of spiral galaxies with the N-body/smoothed particle hydrodynamics method, including cooling, star formation, and stellar feedback. Initial conditions are set to 14 isolated spheres with two free parameters, such as mass and angular momentum. The cold dark matter (h=0.5, Omega0=1) cosmology is considered as a test case. The simulations provide the following two conclusions: (1) The slope of the plane is well reproduced but the zero point is not. This zero-point discrepancy could be solved in a low-density (Omega00.5) cosmology. (2) The surfboard-shaped plane can be explained by the control of galactic mass and angular momentum.

  8. Aptamers Binding to c-Met Inhibiting Tumor Cell Migration.

    Directory of Open Access Journals (Sweden)

    Birgit Piater

    Full Text Available The human receptor tyrosine kinase c-Met plays an important role in the control of critical cellular processes. Since c-Met is frequently over expressed or deregulated in human malignancies, blocking its activation is of special interest for therapy. In normal conditions, the c-Met receptor is activated by its bivalent ligand hepatocyte growth factor (HGF. Also bivalent antibodies can activate the receptor by cross linking, limiting therapeutic applications. We report the generation of the RNA aptamer CLN64 containing 2'-fluoro pyrimidine modifications by systematic evolution of ligands by exponential enrichment (SELEX. CLN64 and a previously described single-stranded DNA (ssDNA aptamer CLN3 exhibited high specificities and affinities to recombinant and cellular expressed c-Met. Both aptamers effectively inhibited HGF-dependent c-Met activation, signaling and cell migration. We showed that these aptamers did not induce c-Met activation, revealing an advantage over bivalent therapeutic molecules. Both aptamers were shown to bind overlapping epitopes but only CLN3 competed with HGF binding to cMet. In addition to their therapeutic and diagnostic potential, CLN3 and CLN64 aptamers exhibit valuable tools to further understand the structural and functional basis for c-Met activation or inhibition by synthetic ligands and their interplay with HGF binding.

  9. Alternative Fuels Data Center: Workplace Charging Success: MetLife

    Science.gov (United States)

    future." Several others noted that their decision to purchase or lease a PEV was based on MetLife's : MetLife " By making PEV charging stations more readily available to employees, we can encourage more promote alternative transportation. By making PEV charging stations more readily available to employees

  10. Invloed krachtvoerniveau op vleesproduktiekenmerken van Piemontese met zwartbont kruislingstieren

    NARCIS (Netherlands)

    Hanekamp, W.J.A.

    1989-01-01

    Met 3 ronden van elk 36 Piemontese X zwartbonte kruislingstieren is het effect van extra krachtvoer vergeleken met de normaal gangbare gift naast onbeperkt snijmaoskuil. De stieren waren gehuisvest in een natuurlijk geventileerde stal (space-boarding)en op een volledige roostervloer.

  11. Interview met Leon Deben: van tegenstellingen leer je het meeste

    NARCIS (Netherlands)

    van Diepen, A.; Huisman, C.

    2008-01-01

    Wat in de jaren zeventig begonnen is als Sociologie van bouwen en wonen is uitgegroeid tot Stadssociologie. Leon Deben heeft het medeopgebouwd. Hij nam onlangs afscheid van de universiteit met een rede over de openbare ruimte. "Het centrale bestuur van de stad is druk met de waan van de dag en dan

  12. Mindfulness voor volwassenen met een licht verstandelijke beperking

    NARCIS (Netherlands)

    Punt, M.; Helmond, P.E.; Meirmans, M.; Otten, R.; Speckens, A.E.M.

    2016-01-01

    Mensen met een licht verstandelijke beperking (LVB) hebben veelal te maken met een opeenstapeling van verschillende biologische, psychologische en sociale factoren, waardoor zij vijf tot zes keer meer kans hebben op het ontwikkelen van psychopathologie dan normaal begaafden (Allen, 2008; Buckles,

  13. 'Epistemology models ontology'− In gesprek met John Polkinghorne

    African Journals Online (AJOL)

    Test

    7 Jun 2011 ... maar met die aard daarvan. Polkinghorne wil met sy boek One World (1996) presies sê wat die titel suggereer. Hiervoor kry hy die oplossing by sy mentor en latere kollega, Paul Dirac. Vir meer as 30 jaar het Dirac dieselfde leerstoel in Fisika aan Cambridge beklee as Isaac Newton (Polkinghorne 2005:34).

  14. Efficacy of c-Met inhibitor for advanced prostate cancer

    International Nuclear Information System (INIS)

    Tu, William H; Zhu, Chunfang; Clark, Curtis; Christensen, James G; Sun, Zijie

    2010-01-01

    Aberrant expression of HGF/SF and its receptor, c-Met, often correlates with advanced prostate cancer. Our previous study showed that expression of c-Met in prostate cancer cells was increased after attenuation of androgen receptor (AR) signalling. This suggested that current androgen ablation therapy for prostate cancer activates c-Met expression and may contribute to development of more aggressive, castration resistant prostate cancer (CRPC). Therefore, we directly assessed the efficacy of c-Met inhibition during androgen ablation on the growth and progression of prostate cancer. We tested two c-Met small molecule inhibitors, PHA-665752 and PF-2341066, for anti-proliferative activity by MTS assay and cell proliferation assay on human prostate cancer cell lines with different levels of androgen sensitivity. We also used renal subcapsular and castrated orthotopic xenograft mouse models to assess the effect of the inhibitors on prostate tumor formation and progression. We demonstrated a dose-dependent inhibitory effect of PHA-665752 and PF-2341066 on the proliferation of human prostate cancer cells and the phosphorylation of c-Met. The effect on cell proliferation was stronger in androgen insensitive cells. The c-Met inhibitor, PF-2341066, significantly reduced growth of prostate tumor cells in the renal subcapsular mouse model and the castrated orthotopic mouse model. The effect on cell proliferation was greater following castration. The c-Met inhibitors demonstrated anti-proliferative efficacy when combined with androgen ablation therapy for advanced prostate cancer

  15. Auxiliary office chair

    OpenAIRE

    Pascual Osés, Maite

    2007-01-01

    The aim of this project is to develop an auxiliary office chair, which favorably will compete with the existing chairs on the market. Evolutions of ergonomical survey in the work environment and on the configuration of offices require new products which fulfill the requirements properly. In order to achieve it a survey about office chairs has been carried out: types, characteristics, ways of usage and products on the market besides a large antropometrical study and ergonomics related to work ...

  16. Coral Reef and Hardbottom from Unified Florida Reef Tract Map (NODC Accession 0123059)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a subset of the Unified Map representing Coral reef and Hardbottom areas. Version 1.1 - December 2013. The Unified Florida Reef Tract Map (Unified...

  17. Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks

    DEFF Research Database (Denmark)

    Dodds, Chris M; Henson, Richard N; Suckling, John

    2013-01-01

    It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activatio...

  18. Multi-office engineering

    International Nuclear Information System (INIS)

    Cowle, E.S.; Hall, L.D.; Koss, P.; Saheb, E.; Setrakian, V.

    1995-01-01

    This paper addresses the viability of multi-office project engineering as has been made possible in a large part by the computer age. Brief discussions are provided on two past projects describing the authors' initial efforts at multi-office engineering, and an in-depth discussion is provided on a current Bechtel project that demonstrates their multi-office engineering capabilities. Efficiencies and cost savings associated with executing an engineering project from multiple office locations was identified as a viable and cost-effective execution approach. The paper also discusses how the need for multi-office engineering came about, what is required to succeed, and where they are going from here. Furthermore, it summarizes the benefits to their clients and to Bechtel

  19. Pragmatic Information as a Unifying Biological Concept

    Directory of Open Access Journals (Sweden)

    Reza Maleeh

    2014-09-01

    Full Text Available This paper aims to introduce a developed reading of Roederer’s interpretation of pragmatic information as a good candidate for a Unifying Information Concept required for an as-yet-unavailable Science of Information. According to pragmatic information, information and information processing are exclusive attributes of biological systems related to the very definition of life. I will apply the notion to give new accounts in the following areas: (1 quantum interpretation: based on a modified version of David Bohm’s interpretation of quantum mechanics, I propose an ontological, information-based interpretation of quantum mechanics which, unlike Roederer’s interpretation, satisfies all conditions of pragmatic information; (2 artificial intelligence: the notion successfully distinguishes natural living systems from artifacts and natural non-living systems, providing a context to pose an information-based argument against the thesis of Strong Artificial Intelligence; (3 phenomenal consciousness: I will use pragmatic information to modify and update Chalmers’s Double-aspect Theory of Information to be explanatorily more powerful regarding the physical aspect of his theory; (4 causation: based on pragmatic information, I pose a new account of causation which differentiates causation in biology from causation in natural abiotic world.

  20. Unified creep-plasticity model for halite

    International Nuclear Information System (INIS)

    Krieg, R.D.

    1980-11-01

    There are two national energy programs which are considering caverns in geological salt (NaCl) as a storage repository. One is the disposal of nuclear wastes and the other is the storage of oil. Both short-time and long-time structural deformations and stresses must be predictable for these applications. At 300K, the nominal initial temperature for both applications, the salt is at 0.28 of the melting temperature and exhibits a significant time dependent behavior. A constitutive model has been developed which describes the behavior observed in an extensive set of triaxial creep tests. Analysis of these tests showed that a single deformation mechanism seems to be operative over the stress and temperature range of interest so that the secondary creep data can be represented by a power of the stress over the entire test range. This simple behavior allowed a new unified creep-plasticity model to be applied with some confidence. The resulting model recognizes no inherent difference between plastic and creep strains yet models the total inelastic strain reasonably well including primary and secondary creep and reverse loadings. A multiaxial formulation is applied with a back stress. A Bauschinger effect is exhibited as a consequence and is present regardless of the time scale over which the loading is applied. The model would be interpreted as kinematic hardening in the sense of classical plasticity. Comparisons are made between test data and model behavior

  1. Randomized central limit theorems: A unified theory.

    Science.gov (United States)

    Eliazar, Iddo; Klafter, Joseph

    2010-08-01

    The central limit theorems (CLTs) characterize the macroscopic statistical behavior of large ensembles of independent and identically distributed random variables. The CLTs assert that the universal probability laws governing ensembles' aggregate statistics are either Gaussian or Lévy, and that the universal probability laws governing ensembles' extreme statistics are Fréchet, Weibull, or Gumbel. The scaling schemes underlying the CLTs are deterministic-scaling all ensemble components by a common deterministic scale. However, there are "random environment" settings in which the underlying scaling schemes are stochastic-scaling the ensemble components by different random scales. Examples of such settings include Holtsmark's law for gravitational fields and the Stretched Exponential law for relaxation times. In this paper we establish a unified theory of randomized central limit theorems (RCLTs)-in which the deterministic CLT scaling schemes are replaced with stochastic scaling schemes-and present "randomized counterparts" to the classic CLTs. The RCLT scaling schemes are shown to be governed by Poisson processes with power-law statistics, and the RCLTs are shown to universally yield the Lévy, Fréchet, and Weibull probability laws.

  2. Argumentation and Inference: A Unified Approach

    Directory of Open Access Journals (Sweden)

    Christophe Fouqueré

    2013-12-01

    Full Text Available We propose in this paper to use Ludics as a unified framework for the analysis of dialogue and the reasoning system. Not only is Ludics a logical theory, but it may also be built by means of concepts of game theory. We first present the main concepts of Ludics. A design is an abstraction and a generalization of the concept of proof. Interaction between designs is equivalent to cut elimination or modus ponens in logical theories. It appears to be a natural means for representing dialogues and also for reasoning. A design is a set of sequences of alternate actions, similar to a move in game theory. We apply Ludics to argumentative dialogues. We discuss how to model the speech acts of argumentative dialogues in terms of dialogue acts. A dialogue act is given by a Ludics action together with the expression that reveals the action in a turn of speech. We show also how arguments may be stored in a commitment state used for reasoning. Finally we revisit an example of juridical dialogue that has been analyzed by Prakken in a different framework.

  3. Unifying Theories of Psychedelic Drug Effects

    Directory of Open Access Journals (Sweden)

    Link R. Swanson

    2018-03-01

    Full Text Available How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In this article I review theories of psychedelic drug effects and highlight key concepts which have endured over the last 125 years of psychedelic science. First, I describe the subjective phenomenology of acute psychedelic effects using the best available data. Next, I review late 19th-century and early 20th-century theories—model psychoses theory, filtration theory, and psychoanalytic theory—and highlight their shared features. I then briefly review recent findings on the neuropharmacology and neurophysiology of psychedelic drugs in humans. Finally, I describe recent theories of psychedelic drug effects which leverage 21st-century cognitive neuroscience frameworks—entropic brain theory, integrated information theory, and predictive processing—and point out key shared features that link back to earlier theories. I identify an abstract principle which cuts across many theories past and present: psychedelic drugs perturb universal brain processes that normally serve to constrain neural systems central to perception, emotion, cognition, and sense of self. I conclude that making an explicit effort to investigate the principles and mechanisms of psychedelic drug effects is a uniquely powerful way to iteratively develop and test unifying theories of brain function.

  4. Texture Repairing by Unified Low Rank Optimization

    Institute of Scientific and Technical Information of China (English)

    Xiao Liang; Xiang Ren; Zhengdong Zhang; Yi Ma

    2016-01-01

    In this paper, we show how to harness both low-rank and sparse structures in regular or near-regular textures for image completion. Our method is based on a unified formulation for both random and contiguous corruption. In addition to the low rank property of texture, the algorithm also uses the sparse assumption of the natural image: because the natural image is piecewise smooth, it is sparse in certain transformed domain (such as Fourier or wavelet transform). We combine low-rank and sparsity properties of the texture image together in the proposed algorithm. Our algorithm based on convex optimization can automatically and correctly repair the global structure of a corrupted texture, even without precise information about the regions to be completed. This algorithm integrates texture rectification and repairing into one optimization problem. Through extensive simulations, we show our method can complete and repair textures corrupted by errors with both random and contiguous supports better than existing low-rank matrix recovery methods. Our method demonstrates significant advantage over local patch based texture synthesis techniques in dealing with large corruption, non-uniform texture, and large perspective deformation.

  5. Constraints on grand unified superstring theories

    International Nuclear Information System (INIS)

    Ellis, J.; Lopez, J.L.; Nanopoulos, D.V.; Houston Advanced Research Center

    1990-01-01

    We evaluate some constraints on the construction of grand unified superstring theories (GUSTs) using higher level Kac-Moody algebras on the world-sheet. In the most general formulation of the heterotic string in four dimensions, an analysis of the basic GUST model-building constraints, including a realistic hidden gauge group, reveals that there are no E 6 models and any SO(10) models can only exist at level-5. Also, any such SU(5) models can exist only for levels 4≤k≤19. These SO(10) and SU(5) models risk having many large, massless, phenomenologically troublesome representations. We also show that with a suitable hidden sector gauge group, it is possible to avoid free light fractionally charged particles, which are endemic to string derived models. We list all such groups and their representations for the flipped SU(5)xU(1) model. We conclude that a sufficiently binding hidden sector gauge group becomes a basic model-building constraint. (orig.)

  6. A Unified Model for Tidal Disruption Events

    Science.gov (United States)

    Dai, Lixin; McKinney, Jonathan C.; Roth, Nathaniel; Ramirez-Ruiz, Enrico; Miller, M. Coleman

    2018-06-01

    In the past few years wide-field optical and UV transient surveys and X-ray telescopes have allowed us to identify a few dozen candidate tidal disruption events (TDEs). While in theory the physical processes in TDEs are ubiquitous, a few distinct classes of TDEs have been observed. Some TDEs radiate mainly in NUV/optical, while others produce prominent X-rays. Moreover, relativistic jets have been observed in only a handful of TDEs. This diversity might be related to the details of the super-Eddington accretion and emission physics relevant to TDE disks. In this Letter, we utilize novel three-dimensional general relativistic radiation magnetohydrodynamics simulations to study the super-Eddington compact disk phase expected in TDEs. Consistent with previous studies, geometrically thick disks, wide-angle optically thick fast outflows, and relativistic jets are produced. The outflow density and velocity depend sensitively on the inclination angle, and hence so does the reprocessing of emission produced from the inner disk. We then use Monte Carlo radiative transfer to calculate the reprocessed spectra and find that that the observed ratio of optical to X-ray fluxes increases with increasing inclination angle. This naturally leads to a unified model for different classes of TDEs in which the spectral properties of the TDE depend mainly on the viewing angle of the observer with respect to the orientation of the disk.

  7. A unified grand tour of theoretical physics

    CERN Document Server

    Griffiths, J

    2002-01-01

    Anyone offering a grand tour is faced with several options. Should they concentrate on what may be considered to be essential features, or should they attempt to present a brief glimpse of almost everything? The present offering is a compromise between these two extremes. The area considered - theoretical physics - is now such a vast subject that some kind of compromise is essential. Indeed, the field is now so wide that few could even attempt to review it in a single-authored work. My task here is to assess how well this book has succeeded in its main aim of providing a unified (though introductory) tour of this subject. Constrained within a single volume, this is clearly not an updated Landau-Lifschitz. It cannot be expected to take any particular topic to the level of recent research. Nevertheless, it does seem to cover the broad range of essential topics which now constitute the subject. It starts (most appropriately in my opinion) with geometry. It then covers classical physics, general relativity and qu...

  8. Unifying Theories of Psychedelic Drug Effects

    Science.gov (United States)

    Swanson, Link R.

    2018-01-01

    How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In this article I review theories of psychedelic drug effects and highlight key concepts which have endured over the last 125 years of psychedelic science. First, I describe the subjective phenomenology of acute psychedelic effects using the best available data. Next, I review late 19th-century and early 20th-century theories—model psychoses theory, filtration theory, and psychoanalytic theory—and highlight their shared features. I then briefly review recent findings on the neuropharmacology and neurophysiology of psychedelic drugs in humans. Finally, I describe recent theories of psychedelic drug effects which leverage 21st-century cognitive neuroscience frameworks—entropic brain theory, integrated information theory, and predictive processing—and point out key shared features that link back to earlier theories. I identify an abstract principle which cuts across many theories past and present: psychedelic drugs perturb universal brain processes that normally serve to constrain neural systems central to perception, emotion, cognition, and sense of self. I conclude that making an explicit effort to investigate the principles and mechanisms of psychedelic drug effects is a uniquely powerful way to iteratively develop and test unifying theories of brain function. PMID:29568270

  9. Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.

    Science.gov (United States)

    Dodds, Chris M; Henson, Richard N; Suckling, John; Miskowiak, Kamilla W; Ooi, Cinly; Tait, Roger; Soltesz, Fruzsina; Lawrence, Phil; Bentley, Graham; Maltby, Kay; Skeggs, Andrew; Miller, Sam R; McHugh, Simon; Bullmore, Edward T; Nathan, Pradeep J

    2013-01-01

    It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including an investigation of the effect of met allele load on memory related activation in the medial temporal lobe. In contrast to previous studies, we found no evidence for an effect of BDNF genotype or met load during episodic memory encoding. Met allele carriers showed increased activation during successful retrieval in right hippocampus but this was contrast-specific and unaffected by met allele load. These results suggest that the BDNF Val66Met polymorphism does not, as previously claimed, exert an observable effect on neural systems underlying encoding of new information into episodic memory but may exert a subtle effect on the efficiency with which such information can be retrieved.

  10. Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.

    Directory of Open Access Journals (Sweden)

    Chris M Dodds

    Full Text Available It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including an investigation of the effect of met allele load on memory related activation in the medial temporal lobe. In contrast to previous studies, we found no evidence for an effect of BDNF genotype or met load during episodic memory encoding. Met allele carriers showed increased activation during successful retrieval in right hippocampus but this was contrast-specific and unaffected by met allele load. These results suggest that the BDNF Val66Met polymorphism does not, as previously claimed, exert an observable effect on neural systems underlying encoding of new information into episodic memory but may exert a subtle effect on the efficiency with which such information can be retrieved.

  11. Acoustic conditions in open plan offices – Pilot test results

    Directory of Open Access Journals (Sweden)

    Witold Mikulski

    2016-10-01

    Full Text Available Background: The main source of noise in open plan office are conversations. Office work standards in such premises are attained by applying specific acoustic adaptation. This article presents the results of pilot tests and acoustic evaluation of open space rooms. Material and Methods: Acoustic properties of 6 open plan office rooms were the subject of the tests. Evaluation parameters, measurement methods and criterial values were adopted according to the following standards: PN-EN ISO 3382- 3:2012, PN-EN ISO 3382-2:2010, PN-B-02151-4:2015-06 and PN-B-02151-3:2015-10. Results: The reverberation time was 0.33– 0.55 s (maximum permissible value in offices – 0.6 s; the criterion was met, sound absorption coefficient in relation to 1 m2 of the room’s plan was 0.77–1.58 m2 (minimum permissible value – 1.1 m2; 2 out of 6 rooms met the criterion, distraction distance was 8.5–14 m (maximum permissible value – 5 m; none of the rooms met the criterion, A-weighted sound pressure level of speech at a distance of 4 m was 43.8–54.7 dB (maximum permissible value – 48 dB; 2 out of 6 rooms met the criterion, spatial decay rate of the speech was 1.8–6.3 dB (minimum permissible value – 7 dB; none of the rooms met the criterion. Conclusions: Standard acoustic treatment, containing sound absorbing suspended ceiling, sound absorbing materials on the walls, carpet flooring and sound absorbing workplace barriers, is not sufficient. These rooms require specific advanced acoustic solutions. Med Pr 2016;67(5:653–662

  12. Role of Met Axis in Head and Neck Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Yiru, E-mail: xuyiru@umich.edu; Fisher, Gary J., E-mail: xuyiru@umich.edu [Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 (United States)

    2013-11-26

    Head and neck cancer is the sixth most common type of cancer worldwide. Despite advances in aggressive multidisciplinary treatments, the 5-year survival rate for this dreadful disease is only 50%, mostly due to high rate of recurrence and early involvement of regional lymph nodes and subsequent metastasis. Understanding the molecular mechanisms responsible for invasion and metastasis is one of the most pressing goals in the field of head and neck cancer. Met, also known as hepatocyte growth factor receptor (HGFR), is a member of the receptor protein tyrosine kinase (RPTK) family. There is compelling evidence that Met axis is dysregulated and plays important roles in tumorigenesis, progression, metastasis, angiogenesis, and drug resistance in head and neck cancer. We describe in this review current understanding of Met axis in head and neck cancer biology and development of therapeutic inhibitors targeting Met axis.

  13. Met flora meer fauna de stad in trekken

    NARCIS (Netherlands)

    Hoffman, M.H.A.

    2010-01-01

    Meer flora en fauna in de stedelijke omgeving begint met de aanplant van gevarieerd groen. Plant Publicity Holland geeft in een overzicht aan welke bomen, heesters en vaste planten daarvoor geschikt zijn.

  14. Mars MetNet Mission - Martian Atmospheric Observational Post Network

    Science.gov (United States)

    Harri, A.-M.; Haukka, H.; Aleksashkin, S.; Arruego, I.; Schmidt, W.; Genzer, M.; Vazquez, L.; Siikonen, T.; Palin, M.

    2017-09-01

    A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

  15. Leven met de varroamijt in de 21ste eeuw

    NARCIS (Netherlands)

    Blacquiere, T.; Cornelissen, B.; Smeekens, C.C.; Steen, van der J.J.M.

    2002-01-01

    Overzicht van voorhanden bestrijdingsmethoden tegen Varroa destructor op de korte termijn en vooruitzichten voor de bestrijding op langere termijn. In de nabije toekomst gaat het om bestrijding met diergeneesmiddelen van natuurlijke oorsprong (mierenzuur, oxaalzuur, thymol) in het kader van een

  16. Mars MetNet Mission - Martian Atmospheric Observational Post Network

    Science.gov (United States)

    Hari, Ari-Matti; Haukka, Harri; Aleksashkin, Sergey; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Siikonen, Timo; Palin, Matti

    2017-04-01

    A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. 1. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. 2. Strawman Scientific Payload The strawman payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: - MetBaro Pressure device - MetHumi Humidity device - MetTemp Temperature sensors Optical devices: - PanCam Panoramic - MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer - DS Dust sensor Composition and Structure Devices: Tri-axial magnetometer MOURA Tri-axial System Accelerometer The descent processes dynamic properties are monitored by a special 3-axis

  17. Office 2013 digital classroom

    CERN Document Server

    Holland, Walter

    2013-01-01

    This complete training package makes learning the new Office 2013 even easier! Featuring both a video training DVD and a full-color book, this training package is like having your own personal instructor guiding you through each lesson of learning Office 2013, all while you work at your own pace. The self-paced lessons allow you to discover the new features and capabilities of the new Office suite. Each lesson includes step-by-step instructions and lesson files, and provides valuable video tutorials that complement what you're learning and clearly demonstrate how to do tasks. This essential

  18. Office 2010 Bible

    CERN Document Server

    Walkenbach, John; Groh, Michael R

    2010-01-01

    The best of the best from the bestselling authors of Excel, Word, and PowerPoint Bibles !. Take your pick of applications from the Office 2010 suite and your choice of leading experts to show you how to use them. This Office 2010 Bible features the best-of-the-best content from the Excel 2010 Bible , by "Mr. Spreadsheet" John Walkenbach; the Word 2010 Bible by Microsoft MVP Herb Tyson; the PowerPoint 2010 Bible , by PowerPoint expert Faithe Wempen; and coverage of Access 2010 from Microsoft MVP Michael Alexander. If you want to quickly and effectively begin using Office 2010, start i

  19. Office of the Chief Financial Officer Annual Report 2009

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Jeffrey

    2009-12-15

    Presented is the 2009 Chief Financial Officer's Annual Report. The data included in this report has been compiled from the Budget Office, the Controller, Procurement and Property Management and the Sponsored Projects Office.

  20. A exposição ocupacional ao mercúrio metálico no módulo odontológico de uma unidade básica de saúde localizada na cidade de São Paulo Occupational exposure to metallic mercury in the dentist's office of a public primary health care clinic in the city of São Paulo

    Directory of Open Access Journals (Sweden)

    Débora M. R. Glina

    1997-04-01

    Full Text Available Este artigo visa discutir a exposição ocupacional ao mercúrio metálico de dentistas e assistentes, enfocando a avaliação biológica, os efeitos na saúde e a avaliação ambiental. Os métodos utilizados foram visitas à unidade, avaliação ambiental, mapas de riscos, dosagens de mercúrio urinário e avaliação da saúde. Os resultados referentes ao ambiente e processos de trabalho mostraram: 1 as concentrações de vapor de mercúrio que impregnavam o revestimento ou tubulações de encanamentos variaram entre 0,001 e 0,051 mg/m3 de ar; 2 exposição ocupacional, havendo 62,5% dos trabalhadores com dosagens de mercúrio urinário entre 10 e 49µg/l e 37,5% abaixo de 10 µg/l em 1994. Estes trabalhadores estiveram expostos desde 1992, sendo suas dosagens de mercúrio urinário de 1992 inferiores às atuais; 3 vazamento de mercúrio e amalgamação inadequada, em função de um amalgamador defeituoso; 4 a necessidade de usar um pedaço de camurça para obter um amalgama homogêneo e remover o excesso de mercúrio; 5 a existência de riscos combinados e simultâneos na situação de trabalho. Os resultados concernentes à saúde mostraram: 1 a prevalência de sintomas relativos ao Sistema Nervoso Central; 2sinais do quadro neurológico e/ou do quadro psíquico, mas não do quadro gastrintestinal; 3 intoxicações crônicas de leves a moderadas em 62,5% dos trabalhadores.This paper discusses occupational exposure to metallic mercury among dentists and dental assistants, focusing on biological evaluation, effects on heaith, and environmental evaluation. Methods included visits to the clinic, hazard maps, urinary and environmental mercury measurements, and evaluation of health status. Results for the environment and work processes showed that mercury vapor concentrations impregnating surfaces and piping varied from 0.001 to 0.051 mg/m3 in air; occupational exposure with 62.5% of health workers having HgU ranging from 10 to 49 mg/l and 37

  1. Ontology-based Metadata Portal for Unified Semantics

    Data.gov (United States)

    National Aeronautics and Space Administration — The Ontology-based Metadata Portal for Unified Semantics (OlyMPUS) will extend the prototype Ontology-Driven Interactive Search Environment for Earth Sciences...

  2. The Relationship Between Unified Communications and Big Data ...

    African Journals Online (AJOL)

    pc

    2018-03-05

    Mar 5, 2018 ... Keywords- Big data, Unified Communications, Big Data. Analytics ... sensors through a phenomenon referred to as Internet of. Things (IoT). ... warehouse which utilized when dealing with large quantities of unstructured data.

  3. Constructing 5d orbifold grand unified theories from heterotic strings

    International Nuclear Information System (INIS)

    Kobayashi, Tatsuo; Raby, Stuart; Zhang Renjie

    2004-01-01

    A three-generation Pati-Salam model is constructed by compactifying the heterotic string on a particular T 6 /Z 6 Abelian symmetric orbifold with two discrete Wilson lines. The compactified space is taken to be the Lie algebra lattice G 2 -bar SU(3)-bar SO(4). When one dimension of the SO(4) lattice is large compared to the string scale, this model reproduces many features of a 5d SO(10) grand unified theory compactified on an S 1 /Z 2 orbifold. (Of course, with two large extra dimensions we can obtain a 6d SO(10) grand unified theory.) We identify the orbifold parities and other ingredients of the orbifold grand unified theories in the string model. Our construction provides a UV completion of orbifold grand unified theories, and gives new insights into both field theoretical and string theoretical constructions

  4. On unified-entropy characterization of quantum channels

    International Nuclear Information System (INIS)

    Rastegin, A E

    2012-01-01

    We consider properties of quantum channels with the use of unified entropies. Extremal unravelings of quantum channel with respect to these entropies are examined. The concept of map entropy is extended in terms of the unified entropies. The map (q, s)-entropy is naturally defined as the unified (q, s)-entropy of a rescaled dynamical matrix of given quantum channel. Inequalities of Fannes type are obtained for introduced entropies in terms of both the trace and Frobenius norms of difference between corresponding dynamical matrices. Additivity properties of introduced map entropies are discussed. The known inequality of Lindblad with the entropy exchange is generalized to many of the unified entropies. For the tensor product of a pair of quantum channels, we derive a two-sided estimate on the output entropy of a maximally entangled input state. (paper)

  5. Generalized projective synchronization of a unified chaotic system

    International Nuclear Information System (INIS)

    Yan Jianping; Li Changpin

    2005-01-01

    In the present paper, a simple but efficient control technique of the generalized projective synchronization is applied to a unified chaotic system. Numerical simulations show that this method works very well, which can also be applied to other chaotic systems

  6. A Unified Mathematical Definition of Classical Information Retrieval.

    Science.gov (United States)

    Dominich, Sandor

    2000-01-01

    Presents a unified mathematical definition for the classical models of information retrieval and identifies a mathematical structure behind relevance feedback. Highlights include vector information retrieval; probabilistic information retrieval; and similarity information retrieval. (Contains 118 references.) (Author/LRW)

  7. Unified composite model of all fundamental particles and forces

    International Nuclear Information System (INIS)

    Terazawa, H.

    2000-01-01

    The unified supersymmetric composite model of all fundamental particles (and forces) including not only the fundamental fermions (quarks and leptons) but also the fundamental bosons (gauge bosons and Higgs scalars) is reviewed in detail

  8. Unified Nonlinear Flight Dynamics and Aeroelastic Simulator Tool, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology, Inc. (ZONA) proposes a R&D effort to develop a Unified Nonlinear Flight Dynamics and Aeroelastic Simulator (UNFDAS) Tool that will combine...

  9. Supergravity and the quest for a unified theory

    International Nuclear Information System (INIS)

    Ferrara, S.

    1995-01-01

    The foundation of supergravity and research in its subsequent developments is described. Special emphasis is placed on the impact of supergravity on the search for a unified theory of fundamental interactions. (author)

  10. Features interior design offices

    OpenAIRE

    Novikov, A. S.; National Aviation University, Ukraine

    2014-01-01

    The article examines the laws and the formation of office space inthe current conditions and investigate the application of the latest technical tools aesthetics to improve the quality of design solutions.

  11. Planning for Office Automation.

    Science.gov (United States)

    Mick, Colin K.

    1983-01-01

    Outlines a practical approach to planning for office automation termed the "Focused Process Approach" (the "what" phase, "how" phase, "doing" phase) which is a synthesis of the problem-solving and participatory planning approaches. Thirteen references are provided. (EJS)

  12. NCEP Internal Office Notes

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Centers for Environmental Prediction (NCEP) and its predecessors have produced internal publications, known as Office Notes, since the mid-1950's. In...

  13. Top-down approach to unified supergravity models

    International Nuclear Information System (INIS)

    Hempfling, R.

    1994-03-01

    We introduce a new approach for studying unified supergravity models. In this approach all the parameters of the grand unified theory (GUT) are fixed by imposing the corresponding number of low energy observables. This determines the remaining particle spectrum whose dependence on the low energy observables can now be investigated. We also include some SUSY threshold corrections that have previously been neglected. In particular the SUSY threshold corrections to the fermion masses can have a significant impact on the Yukawa coupling unification. (orig.)

  14. Restrictions on SU(5) as a grand unified theory

    International Nuclear Information System (INIS)

    Shellard, R.C.

    1984-01-01

    Some restrictions imposed upon Grand Unified Theories by dynamical symetry breakdown are examined. They are shown that, in particular, theories SU(5) as symmetry group, with 3 or more fermion families undergo dynamical symmetry breakdown, and some of the fermions will acquire mass at the Grand Unified scale. On the other hand, the SO(10) group, with 3 families is free from this problem. (Author) [pt

  15. Lattice mechanics of ionic crystals - unified study

    International Nuclear Information System (INIS)

    Sengupta, S.; Roy, D.; Basu, A.N.

    1979-01-01

    The up-to-date situation in the understanding of the mechanical properties of ionic solids is reviewed. These properties are determined by the Born-Oppenheimer (B-O) potential energy function. For ionic crystals this potential energy function can be written down with some precision. To keep the expression tractable, the dominant electron deformation, the dipolar deformation, is treated as an adiabatic variable and the energy then becomes a function of both the nuclear coordinates and the ionic dipole moments. All the well known models for ionic crystals are discussed in terms of the energy expression they imply. This makes the comparison straight forward and brings out the essential difference between the models clearly. Next various quantum mechanical treatments for ionic crystals are reviewed. An attempt is made to obtain the B-O potential energy expression using a Heitler-London approach. By comparing the various models one can arrive at some definitive conclusions about the degree of validity and the assumptions underlying these models. Finally a comprehensive review of the results of actual computation on various ionic crystals done by different authors is undertaken. The crucial quantitative results are examined and the success and shortcoming of each calculation are critically analysed. The guiding principle in this part is the unified approach. i.e. to see how far a model with a given set of parameters accounts for both the dynamic and static properties. The discussion is divided in three sections for crystals with sodium chloride, cesium chloride and zinc sulfide structures. Outstanding problems and difficulties in the present understanding are pointed out. (auth.)

  16. Ecocitizen at the office

    CERN Multimedia

    Staff Association

    2014-01-01

    At the office, I do as I would at home At the office, just as at home, we need to stay warm, have light, be equipped (with office material, furniture). We thus need energy and raw materials. This consumption is not without consequences for our environment. How to reduce our consumption? In everyday life, we already have behaviours that allow us to save energy and resources, to sort our waste. At the office it is important to act in the same way as at home, as we spend a lot of time at our workplace. How to act more responsibly at the office, to reduce the environmental impact, and how to stay motivated? Computer, printer, copy machine… or coffee machine. There are quite a few electrical appliances which are indispensable in our office. Always turned on, or almost, they are also often inactive, and it is during these phases of inactivity that two thirds of their consumption occurs. The way one uses the computer is important in order to limit its consumption. Use the sleep mode with care. A c...

  17. Effects of the BDNF Val66Met Polymorphism and Met Allele Load on Declarative Memory Related Neural Networks

    OpenAIRE

    Dodds, Chris M.; Henson, Richard N.; Suckling, John; Miskowiak, Kamilla W.; Ooi, Cinly; Tait, Roger; Soltesz, Fruzsina; Lawrence, Phil; Bentley, Graham; Maltby, Kay; Skeggs, Andrew; Miller, Sam R.; McHugh, Simon; Bullmore, Edward T.; Nathan, Pradeep J.

    2013-01-01

    It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including...

  18. COMT (Val158Met and BDNF (Val66Met Genes Polymorphism in Schizophrenia: A Case-Control Report

    Directory of Open Access Journals (Sweden)

    ramin saravani

    2017-10-01

    Full Text Available Objective: The effects of human brain-derived neurotropic factor (BDNF Val66Met (G>A and the human Catechol-O-methylTransferase (COMT Val158Met (G>A polymorphisms on Schizophrenia (SCZ risk were evaluated.Methods: This case control study included 92 SCZ patients and 92 healthy controls (HCs. Genotyping of both variants were conducted using Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR.Results: The findings showed that BDNF Val66Met (G>A variant increased the risk of SCZ (OR=2.008 95%CI=1.008-4.00, P=0.047, GA vs. GG, OR=3.876 95%CI=1.001-14.925, P=0.049. AA vs. GG, OR=2.272. 95%CI=1.204-4.347, P=0.011, GA+AA vs. GG, OR=2.22 95%CI=1.29-3.82. P=0.005, A vs. G. COMT Val158Met (G>A polymorphism was not associated with the risk/protective of SCZ.Conclusion: The results proposed that BDNF Val66Met (G>A polymorphism may increase the risk of SCZ development and did not support an association between COMT Val158Met (G>A variant and risk/protective of SCZ. Further studies and different ethnicities are recommended to confirm the findings.

  19. A comparison of metabolic syndrome (MetS) risk factors in Filipino women and Filipino American women: a pilot study.

    Science.gov (United States)

    Ancheta, Irma B; Battie, Cynthia A; Tuason, Teresa; Ancheta, Christine V

    2012-01-01

    Cardiovascular disease (CVD) is a significant cause of morbidity and mortality in women of Filipino ethnicity. The objective of our work was to determine if metabolic syndrome (MetS), a modifiable CVD risk factor, differs in women as a function of country of residency and to determine if, CVD prevention strategies need to differ for these groups of Filipino women. Data were collected in community-based health screenings for this cross-sectional study. PARTICIPANTS were recruited at places of worship in southeast United States (n=60) and Central Visayas, Philippines (n=56). Prevalence of MetS and its component factors as defined by the International Diabetes Federation criteria. The prevalence of MetS in Filipino women (FW) and Filipino American women (FAW) groups was similar (52% vs 55%, P=.08) although the prevalence of elevated waist circumference was greater for FAW (78% vs 59%, P=.03). Conversely, the percentage of FW women with risk-associated high-density lipoprotein (HDL) levels was higher than the FAW group (84% vs 42%, PFilipino women regardless of the country of residency although the FAW tended to have higher rates of central obesity while the FW tended to have higher rates of risk-associated HDL levels. Further research should examine the cause of these differences in order to develop better cardiovascular screening and intervention strategies.

  20. 29 CFR 779.219 - Unified operation may be achieved without common control or common ownership.

    Science.gov (United States)

    2010-07-01

    ... Act May Apply; Enterprise Coverage Unified Operation Or Common Control § 779.219 Unified operation may... through “unified operation.” It is clear from the definition that if the described activities are performed through unified operation they will be part of the enterprise whether they are performed by one...

  1. Nordic network of meteorological services engaged in nuclear preparedness - NKS-MetNet

    Energy Technology Data Exchange (ETDEWEB)

    Persson, C; Kolax, M [Swedish Meteorological and Hydrological Institute, SHMI (Sweden); Baklanov, A; Soerensen, Jens H [Danish Meteorological Institute, DMI (Denmark); Sofiev, M; Valkama, I [Finnish Meteorological Institute, FMI (Finland); Karlsdottier, S [Icelandic Meteorological Office, IMO (Ireland); Bartnicki, J; Saltbones, J [Norwegian Meteorological Institute, met.no (Norway)

    2007-03-15

    The current NKS-MetNet project was initiated to strengthen the Nordic collaboration within the field of real-time atmospheric transport modelling for nuclear emergency preparedness and to improve its contacts to the Nordic radiation protection authorities. A backup facility for the network has been established regarding exchange of operational real-time long-range dispersion model calculations. The facility consists of national password protected Web sites, at which some few basic results (maps) of atmospheric dispersion model calculations (forecasts) in emergency situations (or exercises) can be made available to the network. Technical problems at one institute will not influence the calculations or presentations from the other participants, which makes the system robust. The project has fulfilled its main harmonization goal by bringing the Nordic emergency modelling towards more unified approaches of the presentations of results and introduced a voluntary unification of the model output formats. It was left optional to upload raw data in a format enabling import into one of the Decision Support System (DSS) ARGOS or RODOS. However, implementation of either of these formats is feasible only in case of availability and utilization of the systems by the end-users in the specific country. Within the Nordic countries to-date most but not all of the models are capable of producing the ARGOS-compatible results. Another format of the output data supported by almost all MetNet participants is ENSEMBLE a standard developed within the scope of the EC ENSEMBLE project that currently continues on a voluntary basis, regulated by a joint MoU, and covers nearly all European emergency-engaged services. It seems to be feasible to keep the Nordic network of MetNet Web sites also in a near future and continue its development regardless of presence of a third-party large-scale DSS, whether it is ARGOS, RODOS, ENSEMBLE or any other. Foreseen future close cooperation of the

  2. Nordic network of meteorological services engaged in nuclear preparedness - NKS-MetNet

    International Nuclear Information System (INIS)

    Persson, C.; Kolax, M.; Baklanov, A.; Soerensen, Jens H.; Sofiev, M.; Valkama, I.; Karlsdottier, S.; Bartnicki, J.; Saltbones, J.

    2007-03-01

    The current NKS-MetNet project was initiated to strengthen the Nordic collaboration within the field of real-time atmospheric transport modelling for nuclear emergency preparedness and to improve its contacts to the Nordic radiation protection authorities. A backup facility for the network has been established regarding exchange of operational real-time long-range dispersion model calculations. The facility consists of national password protected Web sites, at which some few basic results (maps) of atmospheric dispersion model calculations (forecasts) in emergency situations (or exercises) can be made available to the network. Technical problems at one institute will not influence the calculations or presentations from the other participants, which makes the system robust. The project has fulfilled its main harmonization goal by bringing the Nordic emergency modelling towards more unified approaches of the presentations of results and introduced a voluntary unification of the model output formats. It was left optional to upload raw data in a format enabling import into one of the Decision Support System (DSS) ARGOS or RODOS. However, implementation of either of these formats is feasible only in case of availability and utilization of the systems by the end-users in the specific country. Within the Nordic countries to-date most but not all of the models are capable of producing the ARGOS-compatible results. Another format of the output data supported by almost all MetNet participants is ENSEMBLE a standard developed within the scope of the EC ENSEMBLE project that currently continues on a voluntary basis, regulated by a joint MoU, and covers nearly all European emergency-engaged services. It seems to be feasible to keep the Nordic network of MetNet Web sites also in a near future and continue its development regardless of presence of a third-party large-scale DSS, whether it is ARGOS, RODOS, ENSEMBLE or any other. Foreseen future close cooperation of the

  3. Requirements to be met by the operation manual

    International Nuclear Information System (INIS)

    1981-03-01

    The rule applies to the contents and the lay-out of the operating manual for stationary nuclear power plants. The draft contains: 1. General requirement to be met by the contents of the operating manual. The operating manual to be arranged in 4 parts (part 1: internal rules and regulations; part 2: operation overall plant; part 3: incidents; part 4: operation systems). Safety specifications to be included in the manual, the exemption being the system of technical documentation. 2. General requirements to be met by the lay-out of the operating manual. Comprehensibility; legibility; structure and subdivisions; arrangement of the instructions and design of the manuals cover. 3. Requirements to be met by part 1. Defining the various internal rules and regulations (personnel management); rules and regulations concerning inspections and shift work; maintenance and repair; radiation protection; guard duty and admission; alarm; fire protection; first aid. 4. Requirements to be met by part 2. Provisions and operational limitations; limit values important from the point of view of safety; normal operation; anomalous operation; in-service inspections. 6. Requirements to be met by part 3. 7. Annex: Rules, regulations and stipulations mentioned in the rule draft. (orig.)

  4. Hydrogen storage capacity of titanium met-cars

    International Nuclear Information System (INIS)

    Akman, N; Durgun, E; Yildirim, T; Ciraci, S

    2006-01-01

    The adsorption of hydrogen molecules on the titanium metallocarbohedryne (met-car) cluster has been investigated by using the first-principles plane wave method. We have found that, while a single Ti atom at the corner can bind up to three hydrogen molecules, a single Ti atom on the surface of the cluster can bind only one hydrogen molecule. Accordingly, a Ti 8 C 12 met-car can bind up to 16 H 2 molecules and hence can be considered as a high-capacity hydrogen storage medium. Strong interaction between two met-car clusters leading to the dimer formation can affect H 2 storage capacity slightly. Increasing the storage capacity by directly inserting H 2 into the met-car or by functionalizing it with an Na atom have been explored. It is found that the insertion of neither an H 2 molecule nor an Na atom could further promote the H 2 storage capacity of a Ti 8 C 12 cluster. We have also tested the stability of the H 2 -adsorbed Ti 8 C 12 met-car with ab initio molecular dynamics calculations which have been carried out at room temperature

  5. MetReS, an Efficient Database for Genomic Applications.

    Science.gov (United States)

    Vilaplana, Jordi; Alves, Rui; Solsona, Francesc; Mateo, Jordi; Teixidó, Ivan; Pifarré, Marc

    2018-02-01

    MetReS (Metabolic Reconstruction Server) is a genomic database that is shared between two software applications that address important biological problems. Biblio-MetReS is a data-mining tool that enables the reconstruction of molecular networks based on automated text-mining analysis of published scientific literature. Homol-MetReS allows functional (re)annotation of proteomes, to properly identify both the individual proteins involved in the processes of interest and their function. The main goal of this work was to identify the areas where the performance of the MetReS database performance could be improved and to test whether this improvement would scale to larger datasets and more complex types of analysis. The study was started with a relational database, MySQL, which is the current database server used by the applications. We also tested the performance of an alternative data-handling framework, Apache Hadoop. Hadoop is currently used for large-scale data processing. We found that this data handling framework is likely to greatly improve the efficiency of the MetReS applications as the dataset and the processing needs increase by several orders of magnitude, as expected to happen in the near future.

  6. Instructed officers Radiation Protection

    International Nuclear Information System (INIS)

    2007-01-01

    This law contains instructions on the prevention of radiological and contains 4 articles Article I: describe the responsibilities of the institutions that operate within the scope of radiological protection in terms of the number of radiation protection officers and personal Supervisors who available in the practices radiation field. Article II: talking about the conditions of radiation protection officers that must be available in the main officers and working field in larg institutions and thecondition of specific requirements for large enterprises of work permits in the field of radiological work that issued by the Council. Article III: the functions and duties of officers in the prevention of radiological oversee the development of radiation protection programmes in the planning stages, construction and preparing the rules of local labour and what it lead of such tasks.Article IV: radiation protection officers powers: to modify and approve the programme of prevention and radiation safety at the company, stop any unsafe steps, amend the steps of the usage, operation of materials, devices and so on

  7. Rocket experiment METS - Microwave Energy Transmission in Space

    Science.gov (United States)

    Kaya, N.; Matsumoto, H.; Akiba, R.

    A Microwave Energy Transmission in Space (METS) rocket experiment is being planned by the Solar Power Satellite Working Group at the Institute of Space and Astronautical Science in Japan for the forthcoming International Space Year, 1992. The METS experiment is an advanced version of the previous MINIX rocket experiment (Matsumoto et al., 1990). This paper describes a conceptual design of the METS rocket experiment. It aims at verifying a newly developed microwave energy transmission system for space use and to study nonlinear effects of the microwave energy beam in the space plasma environment. A high power microwave of 936 W will be transmitted by the new phased-array antenna from a mother rocket to a separated target (daughter rocket) through the ionospheric plasma. The active phased-array system has a capability of focusing the microwave energy around any spatial point by controlling the digital phase shifters individually.

  8. Rocket experiment METS Microwave Energy Transmission in Space

    Science.gov (United States)

    Kaya, N.; Matsumoto, H.; Akiba, R.

    A METS (Microwave Energy Transmission in Space) rocket experiment is being planned by the SPS (Solar Power Satellite) Working Group at the Institute of Space and Astronautical Science (ISAS) in Japan for the forthcoming International Space Year (ISY), 1992. The METS experiment is an advanced version of our MINIX rocket experiment. This paper describes the conceptual design for the METS rocket experiment. Aims are to verify the feasibility of a newly developed microwave energy transmission system designed for use in space and to study nonlinear effects of the microwave energy beam on space plasma. A high power microwave (936 W) will be transmitted by a new phase-array antenna from a mother rocket to a separate target (daughter rocket) through the Earth's ionospheric plasma. The active phased-array system has the capability of being able to focus the microwave energy at any spatial point by individually controlling the digital phase shifters.

  9. El acertijo de la metáfora visual

    OpenAIRE

    De la Rosa Alzate, Adriana; Universidad Autónoma de Occidente

    2016-01-01

    En este artículo se presentan los resultados de la investigación sobre el proceso de interpretación de la metáfora visual, en niños entre tres y cuatro años de edad. El propósito de la investigación fue dar cuenta del proceso de interpretación de la metáfora visual y del razonamiento involucrado. La metáfora visual se entiende como un fenómeno en el que los objetos representados presentan transformaciones que traen como consecuencia la emergencia de nuevas categorías e incluso la ambigüedad, ...

  10. Met Ed gets reprieve: banks lend tax money

    International Nuclear Information System (INIS)

    Utroska, D.

    1981-01-01

    A consortium of banks agreed to loan Metropolitan Edison $23 million to pay its April 15 state taxes and temporarily relieve a cash-flow problem that is leading to default after the Pennsylvania Public Utility Commission expedited a rate request. The continued solvency of Met Ed is a matter of speculation because the present credit formula is based on liquid assets which the PUC did not address. While the action taken by the bankers gives Met Ed a reprieve, it does not provide a long-term solution. The Revolving Credit Agreement will expire on October 1. Met Ed is still faced with the problem of relicensing Three Mile Island-1 unit and the cost of underwriting the cleanup of the No. 2 unit

  11. The strategic security officer.

    Science.gov (United States)

    Hodges, Charles

    2014-01-01

    This article discusses the concept of the strategic security officer, and the potential that it brings to the healthcare security operational environment. The author believes that training and development, along with strict hiring practices, can enable a security department to reach a new level of professionalism, proficiency and efficiency. The strategic officer for healthcare security is adapted from the "strategic corporal" concept of US Marine Corps General Charles C. Krulak which focuses on understanding the total force implications of the decisions made by the lowest level leaders within the Corps (Krulak, 1999). This article focuses on the strategic organizational implications of every security officer's decisions in the constantly changing and increasingly volatile operational environment of healthcare security.

  12. Remembering the early days of the Met Lab

    International Nuclear Information System (INIS)

    Katz, J.J.

    1990-01-01

    The Met Lab was set up by the war-time Manhattan District, US Corp of Engineers to (i) find a system using normal uranium in which a chain reaction would occur; (ii) to show that if such a chain reaction did occur, it would be possible to separate plutonium chemically from the uranium matrix and the fission products formed in the chain reactions; and (iii) to prepare plans for the large-scale production of plutonium. Chemistry Section C-1 of the Met Lab was assigned the responsibility for developing separation methods for plutonium production on the industrial scale. This report describes some aspects of daily life in Section C-1

  13. Sustainable energy with thermochemical storage; Duurzame energie met thermochemische opslag

    Energy Technology Data Exchange (ETDEWEB)

    Bakker, M. [ECN Efficiency and Infrastructure, Petten (Netherlands)

    2010-03-15

    The Energy research Centre of the Netherlands ECN) foresees an important role for heat in sustainable construction of buildings. Using salt hydrates the surplus of heat can be stored in the summer which then can be used in the winter. By means of thermochemical storage natural gas for heating tap water or houses is no longer necessary. [Dutch] Energieonderzoek Centrum Nederland (ECN) ziet voor warmteopslag een belangrijke rol weggelegd in het duurzaam bouwen. Met behulp van zouthydraten kan de overtollige warmte in de zomer opgeslagen worden om deze in de winter weer vrij te maken. Met deze thermochemische opslag is in de nabije toekomst aardgas overbodig voor de verwarming van kraanwater of woonhuis.

  14. Physiological Signaling and Structure of the HGF Receptor MET

    Directory of Open Access Journals (Sweden)

    Gianluca Baldanzi

    2014-12-01

    Full Text Available The “hepatocyte growth factor” also known as “scatter factor”, is a multifunctional cytokine with the peculiar ability of simultaneously triggering epithelial cell proliferation, movement and survival. The combination of those proprieties results in the induction of an epithelial to mesenchymal transition in target cells, fundamental for embryogenesis but also exploited by tumor cells during metastatization. The hepatocyte growth factor receptor, MET, is a proto-oncogene and a prototypical transmembrane tyrosine kinase receptor. Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis.

  15. Nuclear security officer training

    International Nuclear Information System (INIS)

    Harrington, W.F.

    1981-01-01

    Training has become complex and precise in today's world of critical review and responsibility. Entrusted to a security officer is the success or demise of large business. In more critical environments the security officer is entrusted with the monitoring and protection of life sensitive systems and devices. The awareness of this high visibility training requirement has been addressed by a limited few. Those involved in the nuclear power industry through dedication and commitment to the American public have without a doubt become leading pioneers in demanding training excellence

  16. Nothing From Everything- A Unified Theory

    Science.gov (United States)

    Mehra, Vijay Kumar

    2016-07-01

    Nothing From Everything-A Unified Theory is a philosophical insight into principles of nature through principle of complementary spontaneity and principle of vertical continuity. This work is intended to explain various cosmological phenomena in light of behaviour of particles in range of their respective and relative speed of light. This theory explains creation of Universe from nothing or zero spacetime through scalar energy field collapsing into Higgs field resulting into giving mass to various particles. The energy particles taking origin from nothing while moving away from zero space-time would create space-time of their own order because energy/matter needs space to exist. The particles while moving away from zero space-time would end up in breaking symmetry of matter/energy at their mass infinity (highest possible mass of any particle, which is function of speed of spin). This break in symmetry would lead to curving of particles upon themselves and hence would lead to creation of antiparticles going back in time towards zero spacetime. Therefore the Universe could have been created by alternate layers of particles and antiparticles and also alternate layers of matter and antimatter with decelerating speed of light, which would lead to creation a closed and flat Universe. With increase in mass of Universe (creation of more and more Universe's matter from nothing), the gravitational force of Universe is bound to increase and hence with quantum by quantum increase in gravity, it would apply brakes on relative speed of photon/light out of its reference frame or designated space and hence speed of photon would decrease. If closed and flat Universe was created with decelerating speed of light, then such Universe is bound to contract back with accelerating speed of light which would have inverse impact on gravitational constant across various spacetime zones of Universe. And hence mass bodies would drift away spontaneously purely on basis and proportional to

  17. An Admissions Officer's Credentials

    Science.gov (United States)

    Chronicle of Higher Education, 2007

    2007-01-01

    Marilee Jones has resigned as a dean of admissions at the Massachusetts Institute of Technology after admitting that she had misrepresented her academic degrees when first applying to work at the university in 1979. As one of the nation's most prominent admissions officers--and a leader in the movement to make the application process less…

  18. ERGONOMIC OFFICE POSITION ANALYSIS

    Directory of Open Access Journals (Sweden)

    DUMITRU Bogdan

    2010-07-01

    Full Text Available This paper present the risks faced by people working in the office. In the next pages you will find some methods and suggestions how to prevent the appearance of occupational diseases. These suggestions can help anyone to rearrange his work place in order to make his job more pleasant and healthy.

  19. The Mindful Development Officer

    Science.gov (United States)

    Taft, Deb

    2012-01-01

    Delivering on a commitment to diversity in schools, colleges, and universities is a living, breathing endeavor for many members of the advancement community. While a diversity leadership agenda is set clearly from the top, advancement officers can and must play a critical role in this arena. Effective development and alumni leaders are uniquely…

  20. Office of the Ombudsman.

    Science.gov (United States)

    Office of Federal Student Aid (ED), Washington, DC.

    This pamphlet describes the Federal Student Aid Ombudsman, an impartial resource to help customers resolve student loan concerns when other approaches fail. The ombudsman helps resolve discrepancies in loan balances and payments, and helps customers understand interest and collection charges. The office helps resolve issues related to income tax…

  1. Users Office - Removal

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    As of 8 December 2010 and until the end of February 2011, the Users Office will move from Bldg. 60. New Location : Bldg. 510-R-033 Opening Hours: Monday, Tuesday, Thursday, Friday : 08.30 – 12.30 Monday to Friday: 14.00 – 16.00 Closed Wednesday mornings.

  2. Office-based anaesthesia

    African Journals Online (AJOL)

    infection, and consistency in nursing personnel. In the USA 17 -. 24% of all elective ambulatory surgery is ... knowledge base or personality to deal with the OBA environment. Compared with hospitals, office-based facilities currently ... disease or major cardiovascular risk factors). Intravenous access via a flexible cannula is.

  3. Financing medical office buildings.

    Science.gov (United States)

    Blake, J W

    1995-01-01

    This article discusses financing medical office buildings. In particular, financing and ownership options from a not-for-profit health care system perspective are reviewed, including use of tax-exempt debt, taxable debt, limited partnerships, sale, and real estate investment trusts (REITs).

  4. Zuivering brouwerijprocesafvalwater met behulp van microalgen: Resultaten onderzoek 2012

    NARCIS (Netherlands)

    Dijk, van W.; Schipperus, R.; Grobben, S.A.; Weide, van der R.Y.

    2013-01-01

    In een samenwerkingsverband van Heineken Nederland BV, Algae Food & Fuel en WUR (Acrres) is in 2012 een onderzoeksproject gestart om de mogelijkheden van zuivering van procesafvalwater van de brouwerijen met behulp van algen te onderzoeken. In het kader van dit project is in 2012 een

  5. Christus' offer bij Paulus vergeleken met de offeropvattingen van Philo

    NARCIS (Netherlands)

    Stelma, Juurd Hari

    1938-01-01

    Een vergelijking der offeropvattingen van Paulus en Philo brengt ons in aanraking met twee principieel verschillende voorstellingen aangaande het offer. Het offer van Christus is voor Paulus de gave Gods, waardoor de macht van de zonde en dood vernietigd en de schuld verzoend is. Door de

  6. Constant Cremer, voetballer in Tilburg met Afrikaanse wortels

    NARCIS (Netherlands)

    Drs. Thijs Kemmeren

    2012-01-01

    Constant Cremer is de eerste zwarte voetballer in Nederland. Hij is geboren in Belgisch Congo. Hij speelde bij Willem II in het seizoen 1904 -1905 en werd met Willem II Brabvants kampioen. Constant werd, als een donkere mulat een held in Tilburg. Hij kwam uiteindelijk terecht in Nederland Indie en

  7. Workshop ALOUD 'Onderzoek voor, door en met de OU'

    NARCIS (Netherlands)

    Gijselaers, Jérôme; De Groot, Renate

    2015-01-01

    Vraagt u zich wel eens af wat de doorsnee kenmerken zijn van de OU-student? Hoeveel studenten daadwerkelijk starten met de studeren? Wie van deze groep succesvol zijn? En welke verschillen er zitten tussen de faculteiten? En wilt u meedenken over wat voor details we van studenten willen weten voor

  8. Beoordeling gezondheidsrisico's door sporten op kunstgrasvelden met rubbergranulaat

    NARCIS (Netherlands)

    Oomen AG; de Groot GM; CPV; M&V

    2016-01-01

    Uit nieuw onderzoek van het RIVM blijkt dat het risico voor de gezondheid van sporten op kunstgrasvelden die zijn ingestrooid met rubbergranulaat, praktisch verwaarloosbaar is. Dat betekent dat het verantwoord is om op deze velden te sporten. Aanleiding voor het onderzoek is de maatschappelijke

  9. Van Weel: "Werken met minimumbuis de gebruikelijke, maar foute weg"

    NARCIS (Netherlands)

    Staalduinen, van J.; Weel, van P.A.

    2008-01-01

    Door het aanzuigen en in de kas brengen van relatief droge, voorverwarmde buitenlucht is de RV in de kas te verlagen en beter te beheersen. Omdat ook de verticale temperatuurverschillen afnemen, is het mogelijk om intensiever te schermen. Met Aircobreezeventilatoren, die via kieren of gaten lucht

  10. Ervaringen met ICT-onderzoek in het HBO.

    NARCIS (Netherlands)

    van Leeuwen, H.; Teeuw, W.J.; Tangelder, R.; Griffioen, P.; Krose, B.; Schouten, B.

    2011-01-01

    In dit artikel wordt het belang aangegeven van onderzoeksvaardigheden in het HBO. Met de komst van de lectoraten en de nieuwe positionering van het HBO is het belangrijk om een antwoord te vinden hoe het onderzoek binnen het HBO vormgegeven moet worden. Hierbij wordt gekeken naar de bruikbaarheid

  11. Imidacloprid of niet? (interview met Sjef van der Steen)

    NARCIS (Netherlands)

    Kleis, R.; Steen, van der J.J.M.

    2014-01-01

    Is bijensterfte het werk van neonicotinoïden? Ja, zeggen en denken velen. Volgens hen zijn de neo’s rechtstreeks verantwoordelijk voor de hoge sterfte onder bijen. Nee, toont Wagenings onderzoek aan. Intussen lijkt het met de sterfte voorzichtig de goede kant op te gaan.

  12. Vers bloed voor spinazie (interview met C. Kik)

    NARCIS (Netherlands)

    Nijland, R.; Kik, C.

    2011-01-01

    Chris Kik van het Centrum voor Genetische Bronnen Nederland (CGN) keerde afgelopen weekend terug van een eenmansexpeditie door Azerbeidzjan, Georgië en Armenië. Resultaat van de reis: een koffer volgepropt met 53 witte linnen zakjes zaad van wilde en lokaal geteelde spinazie. Dat materiaal gaat

  13. Slim in het verkeer met open data : adviesrapport

    NARCIS (Netherlands)

    Boelens, Danny; Plasmeyer, Luuk; van Heesewijk, Nick; Smeenge, Tetiana; Hoekzema, Niek; McCreesh, Séamus

    2013-01-01

    Rapport in opdracht van de gemeente Groningen. Aanleiding voor het schrijven van dit rapport is dat de gemeente Groningen graag wil weten hoe ze met het gebruik van open data het (openbaar) vervoer voor studenten in en naar de stad Groningen kunnen verbeteren. Het onderzoek richtte zich daarom op

  14. Een bepalingsmethode voor thallium in regenwater met behulp van voltammetrie

    NARCIS (Netherlands)

    Struijs; J.; Wolfs; P.M.; Esseveld; F.G.van

    1985-01-01

    In dit rapport wordt een bepalingmethode beschreven voor thallium in het nanogram/liter-gebied, waarbij gebruik wordt gemaakt van differentiele pulse-anodic stripping voltammetry (DPASV) aan de dunne kwikfilm. Met deze techniek blijkt het mogelijk om de concentratie van dit element rechtstreeks

  15. Subtiel verleiden met nudging : Verhogen van enquêterespons

    NARCIS (Netherlands)

    V. Versluis; dr. A.F. de Wild

    2015-01-01

    De nonrespons op enquêtes onder studenten is vaak hoog, waardoor verkregen informatie niet altijd betrouwbaar en valide is. Met nudges, subtiele interventies die gebaseerd zijn op inzichten uit de psychologie en sociologie, kan de respons op enquêtes aanzienlijk worden verhoogd. Bij de uitrol van

  16. Aan de slag met honors : praktijklessen uit Europa

    NARCIS (Netherlands)

    Wolfensberger, Marca; Hogenstijn, Maarten

    2015-01-01

    In de brochure ‘Aan de slag met honors’ worden onderzoeksresultaten van het onderzoeksproject Honors in Europe hertaald naar tips voor succesvol en inspirerend honorsonderwijs. De brochure is grotendeels gebaseerd op het boek Talent Development in European Higher Education – Honors programs in the

  17. San Diego Met High School: Personalization as a Foundation

    Science.gov (United States)

    Principal Leadership, 2010

    2010-01-01

    The mission of San Diego Met High School is to prepare students for college and the workforce through active learning, academic rigor, and community involvement in a small school setting. Because personalization is a key component of the school culture, advisories of 20-25 students work with the same teachers for all four years. Advisers, parents,…

  18. Randvoorwaarden ontwerp happy games voor ouderen met dementie

    NARCIS (Netherlands)

    Dr. A.L. Cordia

    2014-01-01

    Deze publicatie is in twee fasen tot stand gekomen tijdens het In Touch onderzoek. De eerste fase had als doel de randvoorwaarden te bepalen voor het ontwerpen van drie nieuwe iPad spellen voor ouderen met dementie en betrof een beperkt literatuuronderzoek op gerelateerde onderwerpen, daar

  19. Stalboekje varkens : natuurlijk gezond met kruiden en andere natuurproducten

    NARCIS (Netherlands)

    Groot, M.J.; Kleijer-Ligtenberg, G.; Asseldonk, van T.

    2014-01-01

    Het streven om het gebruik van antibiotica terug te dringen vraagt om een ander management. Goede voeding, huisvesting en hygiëne zijn hierbij belangrijk. In dit boekje worden handvaten gegeven om met natuurlijke middelen de gezondheid van de dieren te bevorderen en zo ziektes te voorkomen. Tevens

  20. Met hard werken alleen is niets mis : werkdruk en stress

    NARCIS (Netherlands)

    Klein Hesselink, J.; Man, M. de; Heeten, W. den

    1996-01-01

    Als men continu onder flinke druk werkt en die druk ook als last wordt ervaren, ontstaan klachten. Omgaan met werkdruk en werkstress is te leren. De cursus 'Anders werken' biedt die mogelijkheid. Dit artikel geeft na enige statische gevens over stress een nadere definiëring van het begrip

  1. Kenmerken en recidivecijfers van ex-terbeschikkinggestelden met een zedendelict

    NARCIS (Netherlands)

    Schönberger, H.J.M.; Kogel, C.H. de; Bregman, I.M.

    2012-01-01

    Dit rapport beschrijft de omvang, achtergrondkenmerken en recidivegegevens van tbs-gestelden met een zedendelict als indexdelict. Het indexdelict is het delict waarvoor de tbs-maatregel is opgelegd. Twee populaties zedendelinquenten komen aan de orde. De eerste populatie, de 'uitstroompopulatie',

  2. Praktijkervaringen met de Venlow energy kas 2010-2012

    NARCIS (Netherlands)

    Kempkes, F.L.K.; Janse, J.

    2013-01-01

    NL De energiebesparing bij het nieuwe telen werd tot nu toe altijd bereikt door meer schermen te gebruiken. Een alternatief is toepassing van isolatieglas dat door de komst van coatings zoals Anti Refl ectie een vergelijkbare transmissie heeft als standaard enkel glas. Met een aangepast

  3. MET-RODOS: A comprehensive atmospheric dispersion module

    DEFF Research Database (Denmark)

    Mikkelsen, T.; Thykier-Nielsen, S.; Astrup, P.

    1997-01-01

    A comprehensive meteorological dispersion module called MET-RODOS is being developed to serve the real-time RODOS(1-3) decision support system with an integrated prediction capability for airborne radioactive spread, deposition and gamma radiation exposure on all scales. Deposition, ground level ...

  4. Vakansiehuis met swembad. Herman Koch. Vertaal deur Daniel ...

    African Journals Online (AJOL)

    - tig minuten (“my verkoopspunt”), maar. “[p]asiënte verwar tyd met aandag”. Marc luistert niet echt, want een huisarts. “hoef mense nie gesond te maak nie” (12). En als ze zich niet laten afschepen, doet hij maar een rectaal touché, want “hulle.

  5. An Adaptive Unified Differential Evolution Algorithm for Global Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, Ji; Mitchell, Chad

    2014-11-03

    In this paper, we propose a new adaptive unified differential evolution algorithm for single-objective global optimization. Instead of the multiple mutation strate- gies proposed in conventional differential evolution algorithms, this algorithm employs a single equation unifying multiple strategies into one expression. It has the virtue of mathematical simplicity and also provides users the flexibility for broader exploration of the space of mutation operators. By making all control parameters in the proposed algorithm self-adaptively evolve during the process of optimization, it frees the application users from the burden of choosing appro- priate control parameters and also improves the performance of the algorithm. In numerical tests using thirteen basic unimodal and multimodal functions, the proposed adaptive unified algorithm shows promising performance in compari- son to several conventional differential evolution algorithms.

  6. Unified Phase Diagram for Iron-Based Superconductors.

    Science.gov (United States)

    Gu, Yanhong; Liu, Zhaoyu; Xie, Tao; Zhang, Wenliang; Gong, Dongliang; Hu, Ding; Ma, Xiaoyan; Li, Chunhong; Zhao, Lingxiao; Lin, Lifang; Xu, Zhuang; Tan, Guotai; Chen, Genfu; Meng, Zi Yang; Yang, Yi-Feng; Luo, Huiqian; Li, Shiliang

    2017-10-13

    High-temperature superconductivity is closely adjacent to a long-range antiferromagnet, which is called a parent compound. In cuprates, all parent compounds are alike and carrier doping leads to superconductivity, so a unified phase diagram can be drawn. However, the properties of parent compounds for iron-based superconductors show significant diversity and both carrier and isovalent dopings can cause superconductivity, which casts doubt on the idea that there exists a unified phase diagram for them. Here we show that the ordered moments in a variety of iron pnictides are inversely proportional to the effective Curie constants of their nematic susceptibility. This unexpected scaling behavior suggests that the magnetic ground states of iron pnictides can be achieved by tuning the strength of nematic fluctuations. Therefore, a unified phase diagram can be established where superconductivity emerges from a hypothetical parent compound with a large ordered moment but weak nematic fluctuations, which suggests that iron-based superconductors are strongly correlated electron systems.

  7. Unified Phase Diagram for Iron-Based Superconductors

    Science.gov (United States)

    Gu, Yanhong; Liu, Zhaoyu; Xie, Tao; Zhang, Wenliang; Gong, Dongliang; Hu, Ding; Ma, Xiaoyan; Li, Chunhong; Zhao, Lingxiao; Lin, Lifang; Xu, Zhuang; Tan, Guotai; Chen, Genfu; Meng, Zi Yang; Yang, Yi-feng; Luo, Huiqian; Li, Shiliang

    2017-10-01

    High-temperature superconductivity is closely adjacent to a long-range antiferromagnet, which is called a parent compound. In cuprates, all parent compounds are alike and carrier doping leads to superconductivity, so a unified phase diagram can be drawn. However, the properties of parent compounds for iron-based superconductors show significant diversity and both carrier and isovalent dopings can cause superconductivity, which casts doubt on the idea that there exists a unified phase diagram for them. Here we show that the ordered moments in a variety of iron pnictides are inversely proportional to the effective Curie constants of their nematic susceptibility. This unexpected scaling behavior suggests that the magnetic ground states of iron pnictides can be achieved by tuning the strength of nematic fluctuations. Therefore, a unified phase diagram can be established where superconductivity emerges from a hypothetical parent compound with a large ordered moment but weak nematic fluctuations, which suggests that iron-based superconductors are strongly correlated electron systems.

  8. Mechanical systems a unified approach to vibrations and controls

    CERN Document Server

    Gans, Roger F

    2015-01-01

    This essential textbook covers analysis and control of engineering mechanisms, which include almost any apparatus with moving parts used in daily life, from musical instruments to robots. The text  presents both vibrations and controls with considerable breadth and depth using a unified notation. It strikes a nice balance between the analytical and the practical.  This text contains enough material for a two semester sequence, but it can also be used in a single semester course combining the two topics. Mechanical Systems: A Unified Approach to Vibrations and Controls presents a common notation and approach to these closely related areas. Examples from the both vibrations and controls components are integrated throughout this text. This book also: ·         Presents a unified approach to vibrations and controls, including an excellent diagram that simultaneously discusses embedding classical vibrations (mechanical systems) in a discussion of models, inverse models, and open and closed loop control ...

  9. Canonical duality theory unified methodology for multidisciplinary study

    CERN Document Server

    Latorre, Vittorio; Ruan, Ning

    2017-01-01

    This book on canonical duality theory provides a comprehensive review of its philosophical origin, physics foundation, and mathematical statements in both finite- and infinite-dimensional spaces. A ground-breaking methodological theory, canonical duality theory can be used for modeling complex systems within a unified framework and for solving a large class of challenging problems in multidisciplinary fields in engineering, mathematics, and the sciences. This volume places a particular emphasis on canonical duality theory’s role in bridging the gap between non-convex analysis/mechanics and global optimization.  With 18 total chapters written by experts in their fields, this volume provides a nonconventional theory for unified understanding of the fundamental difficulties in large deformation mechanics, bifurcation/chaos in nonlinear science, and the NP-hard problems in global optimization. Additionally, readers will find a unified methodology and powerful algorithms for solving challenging problems in comp...

  10. a Unified Matrix Polynomial Approach to Modal Identification

    Science.gov (United States)

    Allemang, R. J.; Brown, D. L.

    1998-04-01

    One important current focus of modal identification is a reformulation of modal parameter estimation algorithms into a single, consistent mathematical formulation with a corresponding set of definitions and unifying concepts. Particularly, a matrix polynomial approach is used to unify the presentation with respect to current algorithms such as the least-squares complex exponential (LSCE), the polyreference time domain (PTD), Ibrahim time domain (ITD), eigensystem realization algorithm (ERA), rational fraction polynomial (RFP), polyreference frequency domain (PFD) and the complex mode indication function (CMIF) methods. Using this unified matrix polynomial approach (UMPA) allows a discussion of the similarities and differences of the commonly used methods. the use of least squares (LS), total least squares (TLS), double least squares (DLS) and singular value decomposition (SVD) methods is discussed in order to take advantage of redundant measurement data. Eigenvalue and SVD transformation methods are utilized to reduce the effective size of the resulting eigenvalue-eigenvector problem as well.

  11. MetAssimulo:Simulation of Realistic NMR Metabolic Profiles

    Directory of Open Access Journals (Sweden)

    De Iorio Maria

    2010-10-01

    Full Text Available Abstract Background Probing the complex fusion of genetic and environmental interactions, metabolic profiling (or metabolomics/metabonomics, the study of small molecules involved in metabolic reactions, is a rapidly expanding 'omics' field. A major technique for capturing metabolite data is 1H-NMR spectroscopy and this yields highly complex profiles that require sophisticated statistical analysis methods. However, experimental data is difficult to control and expensive to obtain. Thus data simulation is a productive route to aid algorithm development. Results MetAssimulo is a MATLAB-based package that has been developed to simulate 1H-NMR spectra of complex mixtures such as metabolic profiles. Drawing data from a metabolite standard spectral database in conjunction with concentration information input by the user or constructed automatically from the Human Metabolome Database, MetAssimulo is able to create realistic metabolic profiles containing large numbers of metabolites with a range of user-defined properties. Current features include the simulation of two groups ('case' and 'control' specified by means and standard deviations of concentrations for each metabolite. The software enables addition of spectral noise with a realistic autocorrelation structure at user controllable levels. A crucial feature of the algorithm is its ability to simulate both intra- and inter-metabolite correlations, the analysis of which is fundamental to many techniques in the field. Further, MetAssimulo is able to simulate shifts in NMR peak positions that result from matrix effects such as pH differences which are often observed in metabolic NMR spectra and pose serious challenges for statistical algorithms. Conclusions No other software is currently able to simulate NMR metabolic profiles with such complexity and flexibility. This paper describes the algorithm behind MetAssimulo and demonstrates how it can be used to simulate realistic NMR metabolic profiles with

  12. An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil

    International Nuclear Information System (INIS)

    Wragg, Joanna; Cave, Mark; Basta, Nick; Brandon, Esther; Casteel, Stan; Denys, Sebastien; Gron, Christian; Oomen, Agnes; Reimer, Kenneth; Tack, Karine; Van de Wiele, Tom

    2011-01-01

    The Bioaccessibility Research Group of Europe (BARGE) has carried out an inter-laboratory trial of a proposed harmonised in vitro physiologically based ingestion bioaccessibility procedure for soils, called the Unified BARGE Method (UBM). The UBM includes an initial saliva phase and simulated stomach and intestine compartments. The trial involved the participation of seven laboratories (five European and two North American) providing bioaccessibility data for As (11 samples), Cd (9 samples) and Pb (13 samples) using soils with in vivo relative bioavailability data measured using a swine model. The results of the study were compared with benchmark criteria for assessing the suitability of the UBM to provide data for human health risk assessments. Mine waste and slag soils containing high concentrations of As caused problems of poor repeatability and reproducibility which were alleviated when the samples were run at lower soil to solution ratios. The study showed that the UBM met the benchmark criteria for both the stomach and stomach and intestine phase for As. For Cd, three out of four criteria were met for the stomach phase but only one for the stomach and intestine phase. For Pb two, out of four criteria were met for the stomach phase and none for the stomach and intestine phase. However, the study recommends tighter control of pH in the stomach phase extraction to improve between-laboratory variability, more reproducible in vivo validation data and that a follow up inter-laboratory trial should be carried out.

  13. An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil

    Energy Technology Data Exchange (ETDEWEB)

    Wragg, Joanna [British Geological Survey, Nottingham (United Kingdom); Cave, Mark, E-mail: mrca@bgs.ac.uk [British Geological Survey, Nottingham (United Kingdom); Basta, Nick [School of Environment and Natural Resources, Ohio State University, Columbus, OH, 43210-1085 (United States); Brandon, Esther [National Institute for Public Health and the Environment, Bilthoven (Netherlands); Casteel, Stan [College of Veterinary Medicine, University of Missouri, 65205 (United States); Denys, Sebastien [INERIS, Parc Technologique Alata, Verneuil-en-Halatte (France); Gron, Christian [DHI Water Environment Health, Horsholm (Denmark); Oomen, Agnes [National Institute for Public Health and the Environment, Bilthoven (Netherlands); Reimer, Kenneth [Environmental Sciences Group, Royal Military College of Canada, Kingston, Ontario (Canada); Tack, Karine [INERIS, Parc Technologique Alata, Verneuil-en-Halatte (France); Van de Wiele, Tom [Laboratory of Microbial Ecology and Technology, University of Ghent, Ghent (Belgium)

    2011-09-01

    The Bioaccessibility Research Group of Europe (BARGE) has carried out an inter-laboratory trial of a proposed harmonised in vitro physiologically based ingestion bioaccessibility procedure for soils, called the Unified BARGE Method (UBM). The UBM includes an initial saliva phase and simulated stomach and intestine compartments. The trial involved the participation of seven laboratories (five European and two North American) providing bioaccessibility data for As (11 samples), Cd (9 samples) and Pb (13 samples) using soils with in vivo relative bioavailability data measured using a swine model. The results of the study were compared with benchmark criteria for assessing the suitability of the UBM to provide data for human health risk assessments. Mine waste and slag soils containing high concentrations of As caused problems of poor repeatability and reproducibility which were alleviated when the samples were run at lower soil to solution ratios. The study showed that the UBM met the benchmark criteria for both the stomach and stomach and intestine phase for As. For Cd, three out of four criteria were met for the stomach phase but only one for the stomach and intestine phase. For Pb two, out of four criteria were met for the stomach phase and none for the stomach and intestine phase. However, the study recommends tighter control of pH in the stomach phase extraction to improve between-laboratory variability, more reproducible in vivo validation data and that a follow up inter-laboratory trial should be carried out.

  14. Towards a Unified Sentiment Lexicon Based on Graphics Processing Units

    Directory of Open Access Journals (Sweden)

    Liliana Ibeth Barbosa-Santillán

    2014-01-01

    Full Text Available This paper presents an approach to create what we have called a Unified Sentiment Lexicon (USL. This approach aims at aligning, unifying, and expanding the set of sentiment lexicons which are available on the web in order to increase their robustness of coverage. One problem related to the task of the automatic unification of different scores of sentiment lexicons is that there are multiple lexical entries for which the classification of positive, negative, or neutral {P,N,Z} depends on the unit of measurement used in the annotation methodology of the source sentiment lexicon. Our USL approach computes the unified strength of polarity of each lexical entry based on the Pearson correlation coefficient which measures how correlated lexical entries are with a value between 1 and −1, where 1 indicates that the lexical entries are perfectly correlated, 0 indicates no correlation, and −1 means they are perfectly inversely correlated and so is the UnifiedMetrics procedure for CPU and GPU, respectively. Another problem is the high processing time required for computing all the lexical entries in the unification task. Thus, the USL approach computes a subset of lexical entries in each of the 1344 GPU cores and uses parallel processing in order to unify 155802 lexical entries. The results of the analysis conducted using the USL approach show that the USL has 95.430 lexical entries, out of which there are 35.201 considered to be positive, 22.029 negative, and 38.200 neutral. Finally, the runtime was 10 minutes for 95.430 lexical entries; this allows a reduction of the time computing for the UnifiedMetrics by 3 times.

  15. Past and future corollaries of theories on causes of metabolic syndrome and obesity related co-morbidities part 2: a composite unifying theory review of human-specific co-adaptations to brain energy consumption.

    Science.gov (United States)

    McGill, Anne-Thea

    2014-01-01

    Metabolic syndrome (MetS) predicts type II diabetes mellitus (TIIDM), cardiovascular disease (CVD) and cancer, and their rates have escalated over the last few decades. Obesity related co-morbidities also overlap the concept of the metabolic syndrome (MetS). However, understanding of the syndrome's underlying causes may have been misapprehended. The current paper follows on from a theory review by McGill, A-T in Archives of Public Health, 72: 30. This accompanying paper utilises research on human evolution and new biochemistry to theorise on why MetS and obesity arise and how they affect the population. The basis of this composite unifying theory is that the proportionately large, energy-demanding human brain may have driven co-adaptive mechanisms to provide, or conserve, energy for the brain. A 'dual system' is proposed. 1) The enlarged, complex cortico-limbic-striatal system increases dietary energy by developing strong neural self-reward/motivation pathways for the acquisition of energy dense food, and (2) the nuclear factor-erythroid 2-related factor 2 (NRF2) cellular protection system amplifies antioxidant, antitoxicant and repair activity by employing plant chemicals. In humans who consume a nutritious diet, the NRF2 system has become highly energy efficient. Other relevant human-specific co-adaptations are explored. In order to 'test' this composite unifying theory it is important to show that the hypothesis and sub-theories pertain throughout the whole of human evolution and history up till the current era. Corollaries of the composite unifying theory of MetS are examined with respect to past under-nutrition and malnutrition since agriculture began 10,000 years ago. The effects of man-made pollutants on degenerative change are examined. Projections are then made from current to future patterns on the state of 'insufficient micronutrient and/or unbalanced high energy malnutrition with central obesity and metabolic dysregulation' or 'malnubesity'. Forecasts

  16. Design of output feedback controller for a unified chaotic system

    International Nuclear Information System (INIS)

    Li Wenlin; Chen Xiuqin; Shen Zhiping

    2008-01-01

    In this paper, the synchronization of a unified chaotic system is investigated by the use of output feedback controllers; a two-input single-output feedback controller and single-input single-output feedback controller are presented to synchronize the unified chaotic system when the states are not all measurable. Compared with the existing results, the controllers designed in this paper have some advantages such as small feedback gain, simple structure and less conservation. Finally, numerical simulations results are provided to demonstrate the validity and effectiveness of the proposed method

  17. Nonlinear adaptive inverse control via the unified model neural network

    Science.gov (United States)

    Jeng, Jin-Tsong; Lee, Tsu-Tian

    1999-03-01

    In this paper, we propose a new nonlinear adaptive inverse control via a unified model neural network. In order to overcome nonsystematic design and long training time in nonlinear adaptive inverse control, we propose the approximate transformable technique to obtain a Chebyshev Polynomials Based Unified Model (CPBUM) neural network for the feedforward/recurrent neural networks. It turns out that the proposed method can use less training time to get an inverse model. Finally, we apply this proposed method to control magnetic bearing system. The experimental results show that the proposed nonlinear adaptive inverse control architecture provides a greater flexibility and better performance in controlling magnetic bearing systems.

  18. Role of baryons in unified dark matter models

    International Nuclear Information System (INIS)

    Beca, L.M.G.; Avelino, P.P.; Carvalho, J.P. de M.; Martins, C.J.A.P.

    2003-01-01

    We discuss the importance of including baryons in analyses of unified dark matter scenarios, focusing on toy models involving a generalized Chaplygin gas. We determine observational constraints on this unified dark matter scenario coming from large-scale structure, type Ia supernovae and CMB data showing how this component can bring about a different behavior from the classical cold dark matter model with a cosmological constant and thus motivate further studies of this type of models. We also speculate on interesting new features which are likely to be important on nonlinear scales in this context

  19. Geometric theory of fundamental interactions. Foundations of unified physics

    International Nuclear Information System (INIS)

    Pestov, A.B.

    2012-01-01

    We put forward an idea that regularities of unified physics are in a simple relation: everything in the concept of space and the concept of space in everything. With this hypothesis as a ground, a conceptual structure of a unified geometrical theory of fundamental interactions is created and deductive derivation of its main equations is produced. The formulated theory gives solution of the actual problems, provides opportunity to understand the origin and nature of physical fields, local internal symmetry, time, energy, spin, charge, confinement, dark energy and dark matter, thus conforming the existence of new physics in its unity

  20. Unified method to integrate and blend several, potentially related, sources of information for genetic evaluation.

    Science.gov (United States)

    Vandenplas, Jérémie; Colinet, Frederic G; Gengler, Nicolas

    2014-09-30

    A condition to predict unbiased estimated breeding values by best linear unbiased prediction is to use simultaneously all available data. However, this condition is not often fully met. For example, in dairy cattle, internal (i.e. local) populations lead to evaluations based only on internal records while widely used foreign sires have been selected using internally unavailable external records. In such cases, internal genetic evaluations may be less accurate and biased. Because external records are unavailable, methods were developed to combine external information that summarizes these records, i.e. external estimated breeding values and associated reliabilities, with internal records to improve accuracy of internal genetic evaluations. Two issues of these methods concern double-counting of contributions due to relationships and due to records. These issues could be worse if external information came from several evaluations, at least partially based on the same records, and combined into a single internal evaluation. Based on a Bayesian approach, the aim of this research was to develop a unified method to integrate and blend simultaneously several sources of information into an internal genetic evaluation by avoiding double-counting of contributions due to relationships and due to records. This research resulted in equations that integrate and blend simultaneously several sources of information and avoid double-counting of contributions due to relationships and due to records. The performance of the developed equations was evaluated using simulated and real datasets. The results showed that the developed equations integrated and blended several sources of information well into a genetic evaluation. The developed equations also avoided double-counting of contributions due to relationships and due to records. Furthermore, because all available external sources of information were correctly propagated, relatives of external animals benefited from the integrated

  1. 75 FR 1007 - MetLife, Inc. and MetLife Capital Trust V; Notice of Application

    Science.gov (United States)

    2010-01-07

    ... the definition of investment company by section 3(b) of the Act or by the rules or regulations under... Act for an exclusion from the definition of an investment company. To the extent MetLife or another... definition of a ``parent company'' in rule 3a-5(b)(2)(i) solely because it is an ``insurance company'' or...

  2. VIDEO: Dr. Henry Rodriguez - Proteogenomics in Cancer Medicine | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Dr. Henry Rodriguez, director of the Office of Cancer Clinical Proteomics Research (OCCPR) at NCI, speaks with ecancer television at WIN 2017 about the translation of the proteins expressed in a patient's tumor into a map for druggable targets. By combining genomic and proteomic information (proteogenomics), leading scientists are gaining new insights into ways to detect and treat cancer due to a more complete and unified understanding of complex biological processes.

  3. The Users Office turns 20

    CERN Multimedia

    2009-01-01

    20 years ago, in the summer of 1989, an office was created to assist the thousands of users who come to CERN each year, working over the broad range of projects and collaborations. Chris Onions (right), head of the Users’ Office, with Bryan Pattison (left), the Office’s founder.Before the inception of the Users Office, it was common for users to spend at least an entire day moving from office to office in search of necessary documentation and information in order to make their stay official. "Though the Office has undergone various changes throughout its lifetime, it has persisted in being a welcoming bridge to facilitate the installation of visitors coming from all over the world", says Chris Onions, head of the Users Office. This September, the Office will celebrate its 20-year anniversary with a drink offered to representatives of the User community, the CERN management and staff members from the services with whom the Office is involved. &...

  4. Activating mutation in MET oncogene in familial colorectal cancer

    Directory of Open Access Journals (Sweden)

    Schildkraut Joellen M

    2011-10-01

    Full Text Available Abstract Background In developed countries, the lifetime risk of developing colorectal cancer (CRC is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherited colon cancer syndromes account for approximately 5%, leaving greater than 20% without clear genetic definition. Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility. Methods MET exons were amplified by PCR from germline DNA of 148 affected sibling pairs with colorectal cancer. Amplicons with altered sequence were detected with high-resolution melt-curve analysis using a LightScanner (Idaho Technologies. Samples demonstrating alternative melt curves were sequenced. A TaqMan assay for the specific c.2975C >T change was used to confirm this mutation in a cohort of 299 colorectal cancer cases and to look for allelic amplification in tumors. Results Here we report a germline non-synonymous change in the MET proto-oncogene at amino acid position T992I (also reported as MET p.T1010I in 5.2% of a cohort of sibling pairs affected with CRC. This genetic variant was then confirmed in a second cohort of individuals diagnosed with CRC and having a first degree relative with CRC at prevalence of 4.1%. This mutation has been reported in cancer cells of multiple origins, including 2.5% of colon cancers, and in Conclusions Although the MET p.T992I genetic mutation is commonly found in somatic colorectal cancer tissues, this is the first report also implicating this MET genetic mutation as a germline inherited risk factor for familial colorectal cancer. Future studies on the cancer risks associated with this mutation and the prevalence in different at-risk populations will

  5. Biases of the MET Temperature and Relative Humidity Sensor (HMP45) Report

    Energy Technology Data Exchange (ETDEWEB)

    Kyrouac, Jenni [Argonne National Lab. (ANL), Argonne, IL (United States); Theisen, Adam [Univ. of Oklahoma, Norman, OK (United States)

    2017-06-30

    The U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility Data Quality (DQ) Office was alerted to a potential bias in the surface meteorological instrumentation (MET) temperature when compared with a nearby Mesonet station. This led to an investigation into this problem that was expanded to include many of the other extended facilities (EF) and both the temperature and relative humidity (RH) variables. For this study, the Mesonet was used as the standard reference due to results that showed an increased accuracy in high-humidity environments along with the fact that the Mesonet had previous documented a problem with the HMP45C sensors. Some differences between the sites were taken into account during the analysis: 1. ARM MET sensors were upgraded from an HMP35 to an HMP45 throughout 2007 2. Mesonet switched to aspirated shields in 2009 – To mitigate the differences between aspirated and non-aspirated measurements, data were only analyzed when the wind speed was higher than 3 m/s. This reduced the uncertainty for the non-aspirated measurements from 1.51 ºC to 0.4 ºC. 3. ARM MET is mounted 0.5m higher than the Mesonet station (2.0m versus 1.5m) – This is assumed to have a negligible effect on the differences. 4. Sites were not co-located – For some locations, the distances between sites were as much as 45 km. As part of the investigation into the differences, the Mesonet had reported that the HMP45 sensors had a low-temperature bias in high-humidity environments. This was verified at two different sites where the ARM measurements were compared with the Mesonet measurements. The Mesonet provided redundant temperature measurements from two different sensors at each site. These measurements compared fairly well, while the ARM sensor showed a bias overnight when the humidities were higher. After reviewing the yearly average differences in the data and analyzing the RH data during fog events when we assume it should be

  6. Operational Numerical Weather Prediction at the Met Office and potential ways forward for operational space weather prediction systems

    Science.gov (United States)

    Jackson, David

    NICT (National Institute of Information and Communications Technology) has been in charge of space weather forecast service in Japan for more than 20 years. The main target region of the space weather is the geo-space in the vicinity of the Earth where human activities are dominant. In the geo-space, serious damages of satellites, international space stations and astronauts take place caused by energetic particles or electromagnetic disturbances: the origin of the causes is dynamically changing of solar activities. Positioning systems via GPS satellites are also im-portant recently. Since the most significant effect of positioning error comes from disturbances of the ionosphere, it is crucial to estimate time-dependent modulation of the electron density profiles in the ionosphere. NICT is one of the 13 members of the ISES (International Space Environment Service), which is an international assembly of space weather forecast centers under the UNESCO. With help of geo-space environment data exchanging among the member nations, NICT operates daily space weather forecast service every day to provide informa-tion on forecasts of solar flare, geomagnetic disturbances, solar proton event, and radio-wave propagation conditions in the ionosphere. The space weather forecast at NICT is conducted based on the three methodologies: observations, simulations and informatics (OSI model). For real-time or quasi real-time reporting of space weather, we conduct our original observations: Hiraiso solar observatory to monitor the solar activity (solar flare, coronal mass ejection, and so on), domestic ionosonde network, magnetometer HF radar observations in far-east Siberia, and south-east Asia low-latitude ionosonde network (SEALION). Real-time observation data to monitor solar and solar-wind activities are obtained through antennae at NICT from ACE and STEREO satellites. We have a middle-class super-computer (NEC SX-8R) to maintain real-time computer simulations for solar and solar-wind, magnetosphere and ionosphere. The three simulations are directly or indirectly connected each other based on real-time observa-tion data to reproduce a virtual geo-space region on the super-computer. Informatics is a new methodology to make precise forecast of space weather. Based on new information and communication technologies (ICT), it provides more information in both quality and quantity. At NICT, we have been developing a cloud-computing system named "space weather cloud" based on a high-speed network system (JGN2+). Huge-scale distributed storage (1PB), clus-ter computers, visualization systems and other resources are expected to derive new findings and services of space weather forecasting. The final goal of NICT space weather service is to predict near-future space weather conditions and disturbances which will be causes of satellite malfunctions, tele-communication problems, and error of GPS navigations. In the present talk, we introduce our recent activities on the space weather services and discuss how we are going to develop the services from the view points of space science and practical uses.

  7. Office hysteroscopy and adenomyosis.

    Science.gov (United States)

    Molinas, Carlos Roger; Campo, Rudi

    2006-08-01

    Adenomyosis, the heterotopic presence of endometrial glands and stroma within the myometrium, has traditionally been diagnosed by the pathologist in hysterectomy specimens. However, the recent development of high-quality non-invasive techniques such as transvaginal sonography (TVS), magnetic resonance imaging (MRI) and hysteroscopy has renewed interest in diagnosing adenomyosis in the office prior to any treatment. Hysteroscopy offers the advantage of direct visualization of the uterine cavity, and since nowadays it is performed in the office, it can be offered as a first-line diagnostic tool for evaluation of uterine abnormalities in patients with abnormal uterine bleeding and/or infertility. The available data clearly indicate that high-quality mini-hysteroscopes, saline as a distension medium, and atraumatic insertion technique are essential for the success of office hysteroscopy. The procedure is indicated in any situation in which an intrauterine anomaly is suspected; it is immediately preceded by a physical exam and a TVS to evaluate uterine characteristics, and it is followed by a second TVS to take advantage of the intracavitary fluid for a contrast image of the uterus. Although diagnostic hysteroscopy does not provide pathognomonic signs for adenomyosis, some evidence suggests that irregular endometrium with endometrial defects, altered vascularization, and cystic haemorrhagic lesion are possibly associated with the entity. In addition to the direct visualization of the uterine cavity, the hysteroscopic approach offers the possibility of obtaining endometrial/myometrial biopsies under visual control. Since they can be performed in the office, the combination of TVS, fluid hysteroscopy and contrast sonography is therefore a powerful screening tool for detecting endometrial and myometrial abnormalities in association with adenomyosis.

  8. Officer Accessions Flow Model

    Science.gov (United States)

    2011-07-31

    officers select their own BOLC-B dates completely divorced of their unit assignment and that unit’s ARFORGEN cycle. We reschedule all FY10 cohort LTs...for BOLC-B based upon unit priority based upon number of days until LAD. Rescheduling all FY10 cohort LTs for BOLC-B based upon unit priority...with specialty branches (doctors, lawyers, nurses , chaplains, etc) which have minimal representation in BCT-level units.  DCs are not generally

  9. Office software Individual coaching

    CERN Multimedia

    HR Department

    2010-01-01

    If one or several particular topics cause you sleepless nights, you can get the help of our trainer who will come to your workplace for a multiple of 1-hour slots . All fields in which our trainer can help are detailed in the course description in our training catalogue (Microsoft Office software, Adobe applications, i-applications etc.). Please discover these new courses in our catalogue! Tel. 74924

  10. MAIL OFFICE Outgoing mail

    CERN Multimedia

    1999-01-01

    The Mail Office once again wishes to remind users that the Organisation's mail service is exclusively reserved for official mail._\tAll outgoing official mail must arrive at the Mail Office unfranked and with the sender's name and Division clearly marked under the Organsation's address (see example below).Private mail must be taken to the Post Offices at Meyrin (63-R-011) or Prévessin (866-R-C02)._\tPlease only use 'PRIORITY' envelopes for mail requiring priority handling. Internal mail_\tPlease do not forget to indicate your correspondent's 'MAILBOX' number on the internal mail envelopes either in the specific box provided (new envelopes) or next to his or her name (old envelopes). This will facilitate and accelerate the handling of your mail. Mailbox numbers can be found on: Macintosh\tin the 'Mailbox' field in 'VIPER'PC\tin the 'Mailbox' field of 'Phone book'Web: http://www.cern.ch/CERN/Phone.htmlin the 'MailBox' fieldonce you have selected your correspondent's name...

  11. Ways of radical change of the image of tax and customs officers

    Directory of Open Access Journals (Sweden)

    Arutiunian V. L.

    2018-03-01

    Full Text Available the article discusses the problem concerning some changes in image of tax and customs officers. Tax and customs system is a multifunctional structure, therefore, in order to ensure unified application of the legislation, professional training of staff should be organized by means of guidelines, workshop discussions, qualification trainings and other instruments, which should be attended by the employees of territorial and regional tax and customs authorities. Along with implementation of legislative reforms and application of advanced technologies for increase of confidence in tax system and expansion of capabilities, the role of a professional tax officer is of high importance.

  12. Estimation of METs by Accelerometers while Walking and Running

    Science.gov (United States)

    Kurihara, Yosuke; Watanabe, Kajiro; Yoneyama, Mitsuru

    It is quite important for Japan to maintain or promote the health condition of elderly citizens. Given the circumstances, the Ministry of Health, Labour and Welfare has established the standards for the activities and exercises for promoting the health, and quantitatively determined the exercise intensity on 107 items of activities. This exercise intensity, however, requires recording the type and the duration of the activity to be calculated. In this paper, the exercise intensities are surmised using 3D accelerometer while the subjects are walking and running. As the result, the exercise intensities were surmised to be within the root mean square error of 1.2[METs] for walking and 3.2[METs] for running respectively.

  13. Testing ATLAS Z+MET excess with LHC run 2

    International Nuclear Information System (INIS)

    Lu, Xiaochuan; Terada, Takahiro

    2016-05-01

    The ATLAS collaboration reported a 3σ excess in the search of events containing on-Z dilepton, jets, and large missing momentum (MET) in the 8 TeV LHC run. Motivated by this excess, many models of new physics have been proposed. Recently, the ATLAS and CMS collaborations reported new results for similar Z+MET channels in the 13 TeV run. In this paper, we comprehensively discuss the consistency between the proposed models and the LHC results of Run 1 and Run 2. We find that in models with heavy gluino production, there is generically some tension between the 8 TeV and 13 TeV results. On the other hand, models with light squark production provide relatively better fitting to both results.

  14. Cetuximab-Induced MET Activation Acts as a Novel Resistance Mechanism in Colon Cancer Cells

    Directory of Open Access Journals (Sweden)

    Na Song

    2014-04-01

    Full Text Available Aberrant MET expression and hepatocyte growth factor (HGF signaling are implicated in promoting resistance to targeted agents; however, the induced MET activation by epidermal growth factor receptor (EGFR inhibitors mediating resistance to targeted therapy remains elusive. In this study, we identified that cetuximab-induced MET activation contributed to cetuximab resistance in Caco-2 colon cancer cells. MET inhibition or knockdown sensitized Caco-2 cells to cetuximab-mediated growth inhibition. Additionally, SRC activation promoted cetuximab resistance by interacting with MET. Pretreatment with SRC inhibitors abolished cetuximab-mediated MET activation and rendered Caco-2 cells sensitive to cetuximab. Notably, cetuximab induced MET/SRC/EGFR complex formation. MET inhibitor or SRC inhibitor suppressed phosphorylation of MET and SRC in the complex, and MET inhibitor singly led to disruption of complex formation. These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer.

  15. MetWAMer: eukaryotic translation initiation site prediction

    Directory of Open Access Journals (Sweden)

    Brendel Volker

    2008-09-01

    Full Text Available Abstract Background Translation initiation site (TIS identification is an important aspect of the gene annotation process, requisite for the accurate delineation of protein sequences from transcript data. We have developed the MetWAMer package for TIS prediction in eukaryotic open reading frames of non-viral origin. MetWAMer can be used as a stand-alone, third-party tool for post-processing gene structure annotations generated by external computational programs and/or pipelines, or directly integrated into gene structure prediction software implementations. Results MetWAMer currently implements five distinct methods for TIS prediction, the most accurate of which is a routine that combines weighted, signal-based translation initiation site scores and the contrast in coding potential of sequences flanking TISs using a perceptron. Also, our program implements clustering capabilities through use of the k-medoids algorithm, thereby enabling cluster-specific TIS parameter utilization. In practice, our static weight array matrix-based indexing method for parameter set lookup can be used with good results in data sets exhibiting moderate levels of 5'-complete coverage. Conclusion We demonstrate that improvements in statistically-based models for TIS prediction can be achieved by taking the class of each potential start-methionine into account pending certain testing conditions, and that our perceptron-based model is suitable for the TIS identification task. MetWAMer represents a well-documented, extensible, and freely available software system that can be readily re-trained for differing target applications and/or extended with existing and novel TIS prediction methods, to support further research efforts in this area.

  16. Phase transitions at finite chemical potential in grand unified theories

    International Nuclear Information System (INIS)

    Bailin, D.; Love, A.

    1984-01-01

    We discuss the circumstances in which non-zero chemical potentials might prevent symmetry restoration in phase transitions in the early universe at grand unification or partial unification scales. The general arguments are illustrated by consideration of SO(10) and SU(5) grand unified theories. (orig.)

  17. About the Possibility of Creation of a Deterministic Unified Mechanics

    International Nuclear Information System (INIS)

    Khomyakov, G.K.

    2005-01-01

    The possibility of creation of a unified deterministic scheme of classical and quantum mechanics, allowing to preserve their achievements is discussed. It is shown that the canonical system of ordinary differential equation of Hamilton classical mechanics can be added with the vector system of ordinary differential equation for the variables of equations. The interpretational problems of quantum mechanics are considered

  18. Designing a framework for a unified electronic identity system ...

    African Journals Online (AJOL)

    In this paper, a Unified Identity System is proposed where single electronic identity (eID) is issued that can be used across the various platforms of business transaction. The activity/state diagram of the model is presented, and the means of authentication is based on the Secure Assertion Markup Language (SAML) ...

  19. A unifying approach to existence of Nash equilibria

    NARCIS (Netherlands)

    Balder, E.J.

    1997-01-01

    An approach initiated in [4] is shown to unify results about the existence of (i) Nash equilibria in games with at most countably many players, (ii) Cournot-Nash equilibrium distributions for large, anonymous games, and (iii) Nash equilibria (both mixed and pure) for continuum games. A new, central

  20. Seismic monitoring: a unified system for research and verifications

    International Nuclear Information System (INIS)

    Thigpen, L.

    1979-01-01

    A system for characterizing either a seismic source or geologic media from observational data was developed. This resulted from an examination of the forward and inverse problems of seismology. The system integrates many seismic monitoring research efforts into a single computational capability. Its main advantage is that it unifies computational and research efforts in seismic monitoring. 173 references, 9 figures, 3 tables

  1. Unified Model for Generation Complex Networks with Utility Preferential Attachment

    International Nuclear Information System (INIS)

    Wu Jianjun; Gao Ziyou; Sun Huijun

    2006-01-01

    In this paper, based on the utility preferential attachment, we propose a new unified model to generate different network topologies such as scale-free, small-world and random networks. Moreover, a new network structure named super scale network is found, which has monopoly characteristic in our simulation experiments. Finally, the characteristics of this new network are given.

  2. Adapting the unified software development process for user interface development

    NARCIS (Netherlands)

    Obrenovic, Z.; Starcevic, D.

    2006-01-01

    In this paper we describe how existing software developing processes, such as Rational Unified Process, can be adapted in order to allow disciplined and more efficient development of user interfaces. The main objective of this paper is to demonstrate that standard modeling environments, based on the

  3. Designing synchronization schemes for chaotic fractional-order unified systems

    International Nuclear Information System (INIS)

    Wang Junwei; Zhang Yanbin

    2006-01-01

    Synchronization in chaotic fractional-order differential systems is studied both theoretically and numerically. Two schemes are designed to achieve chaos synchronization of so-called unified chaotic systems and the corresponding numerical algorithms are established. Some sufficient conditions on synchronization are also derived based on the Laplace transformation theory. Computer simulations are used for demonstration

  4. Modeling of hydrodynamic cavitation reactors: a unified approach

    NARCIS (Netherlands)

    Moholkar, V.S.; Pandit, A.B.

    2001-01-01

    An attempt has been made to present a unified theoretical model for the cavitating flow in a hydrodynamic cavitation reactor using the nonlinear continuum mixture model for two-phase flow as the basis. This model has been used to describe the radial motion of bubble in the cavitating flow in two

  5. The Bjorken-Paschos relation in the unified gauge theory

    International Nuclear Information System (INIS)

    Oh, S.K.

    1980-07-01

    We have examined in the unified gauge theory with the integrally-charged quark model the Bjorken-Paschos relation within the impulse approximation of the parton picture. We find that the relation is valid for the forward scattering region and provides a reliable way to test the charge assignment of the quarks and the gluons. (author)

  6. Catastrophe Theory: A Unified Model for Educational Change.

    Science.gov (United States)

    Cryer, Patricia; Elton, Lewis

    1990-01-01

    Catastrophe Theory and Herzberg's theory of motivation at work was used to create a model of change that unifies and extends Lewin's two separate stage and force field models. This new model is used to analyze the behavior of academics as they adapt to the changing university environment. (Author/MLW)

  7. 78 FR 18235 - Unified Rule for Loss on Subsidiary Stock

    Science.gov (United States)

    2013-03-26

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 Unified Rule for Loss on... first sentence, reinstate the following sentence: Sec. 1.1502-32 Investment adjustments. * * * * * (c... than the time the distribution is taken into account under the Internal Revenue Code (e.g., under...

  8. Teachers' Perceptions of Technology Integration in a Unified School District

    Science.gov (United States)

    Bloodman, Suzette L.

    2014-01-01

    A unified school district (USD) continues to invest millions of dollars into its technology integration initiatives with minimal academic gains. Since teachers are essential to effective technology integration, the purpose of this phenomenological study was to analyze the perceptions of 13 teachers within the USD relative to how they could more…

  9. New unified field theory based on the conformal group

    Energy Technology Data Exchange (ETDEWEB)

    Pessa, E [Rome Univ. (Italy). Ist. di Matematica

    1980-10-01

    Based on a six-dimensional generalization of Maxwell's equations, a new unified theory of the electromagnetic and gravitational field is developed. Additional space-time coordinates are interpreted only as mathematical tools in order to obtain a linear realization of the four-dimensional conformal group.

  10. When Unified Teacher Pay Scales Meet Differential Alternative Returns

    Science.gov (United States)

    Walsh, Patrick

    2014-01-01

    This paper quantifies the extent to which unified teacher pay scales and differential alternatives produce opportunity costs that are asymmetric in math and verbal skills. Data from the Baccalaureate and Beyond 1997 and 2003 follow-ups are used to estimate a fully parametric, selection-corrected wage equation for nonteachers, which is then used to…

  11. Quintessential inflation: A unified scenario of inflation and dark energy

    Directory of Open Access Journals (Sweden)

    Hossain Wali

    2018-01-01

    Full Text Available Quintessential inflation unifies inflation and late time acceleration by a single scalar field. Such a scenario, with canonical and non-canonical scalar fields, has been discussed. The scalar field behaves as an inflaton field during inflation and as a quintessence field during late time. Also the predictions of the models has been compared with the recent Planck data.

  12. A unifying theory The universe on a string

    CERN Multimedia

    Greene, Brian

    2006-01-01

    Seventy-five years ago, Albert Einstein completed his unified field theory; but, as had happened before and would happen again, Einstein had to go bak to the drawing board. Much progress have been inspired, with the most recent advances coming from an approach called string theory. (1,5 page)

  13. Unified Approach to Universal Cloning and Phase-Covariant Cloning

    OpenAIRE

    Hu, Jia-Zhong; Yu, Zong-Wen; Wang, Xiang-Bin

    2008-01-01

    We analyze the problem of approximate quantum cloning when the quantum state is between two latitudes on the Bloch's sphere. We present an analytical formula for the optimized 1-to-2 cloning. The formula unifies the universal quantum cloning (UQCM) and the phase covariant quantum cloning.

  14. The Unified Levelling Network of Sarawak and its Adjustment

    Science.gov (United States)

    Som, Z. A. M.; Yazid, A. M.; Ming, T. K.; Yazid, N. M.

    2016-09-01

    The height reference network of Sarawak has seen major improvement in over the past two decades. The most significant improvement was the establishment of extended precise leveling network of which is now able to connect all three major datum points at Pulau Lakei, Original and Bintulu. Datum by following the major accessible routes across Sarawak. This means the leveling network in Sarawak has now been inter-connected and unified. By having such a unified network leads to the possibility of having a common single least squares adjustment been performed for the first time. The least squares adjustment of this unified levelling network was attempted in order to compute the height of all Bench Marks established in the entire levelling network. The adjustment was done by using MoreFix levelling adjustment package developed at FGHT UTM. The computational procedure adopted is linear parametric adjustment by minimum constraint. Since Sarawak has three separate datums therefore three separate adjustments were implemented by utilizing datum at Pulau Lakei, Original Miri and Bintulu Datum respectively. Results of the MoreFix unified adjustment agreed very well with adjustment repeated using Starnet. Further the results were compared with solution given by Jupem and they are in good agreement as well. The difference in height analysed were within 10mm for the case of minimum constraint at Pulau Lakei datum and with much better agreement in the case of Original Miri Datum.

  15. Towards a unified theory of task-specific motivation

    NARCIS (Netherlands)

    De Brabander, Cornelis; Martens, Rob

    2014-01-01

    This study aims to integrate the current proliferation of motivation theories in a Unified Model of Task-specific Motivation (UMTM). According to this model readiness for action results from an interaction between four relatively independent types of valences that can be classified as affective or

  16. The Vector Space as a Unifying Concept in School Mathematics.

    Science.gov (United States)

    Riggle, Timothy Andrew

    The purpose of this study was to show how the concept of vector space can serve as a unifying thread for mathematics programs--elementary school to pre-calculus college level mathematics. Indicated are a number of opportunities to demonstrate how emphasis upon the vector space structure can enhance the organization of the mathematics curriculum.…

  17. THE UNIFIED LEVELLING NETWORK OF SARAWAK AND ITS ADJUSTMENT

    Directory of Open Access Journals (Sweden)

    Z. A. M. Som

    2016-09-01

    Full Text Available The height reference network of Sarawak has seen major improvement in over the past two decades. The most significant improvement was the establishment of extended precise leveling network of which is now able to connect all three major datum points at Pulau Lakei, Original and Bintulu. Datum by following the major accessible routes across Sarawak. This means the leveling network in Sarawak has now been inter-connected and unified. By having such a unified network leads to the possibility of having a common single least squares adjustment been performed for the first time. The least squares adjustment of this unified levelling network was attempted in order to compute the height of all Bench Marks established in the entire levelling network. The adjustment was done by using MoreFix levelling adjustment package developed at FGHT UTM. The computational procedure adopted is linear parametric adjustment by minimum constraint. Since Sarawak has three separate datums therefore three separate adjustments were implemented by utilizing datum at Pulau Lakei, Original Miri and Bintulu Datum respectively. Results of the MoreFix unified adjustment agreed very well with adjustment repeated using Starnet. Further the results were compared with solution given by Jupem and they are in good agreement as well. The difference in height analysed were within 10mm for the case of minimum constraint at Pulau Lakei datum and with much better agreement in the case of Original Miri Datum.

  18. Unifying weak and electromagnetic forces in Weinberg-Salam theory

    International Nuclear Information System (INIS)

    Savoy, C.A.

    1978-01-01

    In this introduction to the ideas related to the unified gauge theories of the weak and electromagnetic interactions, we begin with the motivations for its basic principles. Then, the formalism is briefly developed, in particular the so-called Higgs mechanism. The advantages and the consequences of the (non-abelian) gauge invariance are emphasized, together with the experimental tests of the theory [fr

  19. Masses of particles in the SO(18) grand unified model

    International Nuclear Information System (INIS)

    Asatryan, G.M.

    1984-01-01

    The grand unified model based on the orthogonal group SO(18) is treated. The model involves four familiar and four mirror families of fermions. Arising of masses of familiar and mirror particles is studied. The mass of the right-handed Wsub(R) boson interacting via right-handed current way is estimated

  20. The coherence problem with th Unified Neutral Theory of biodiversity

    Science.gov (United States)

    James S. Clark

    2012-01-01

    The Unified Neutral Theory of Biodiversity (UNTB), proposed as an alternative to niche theory, has been viewed as a theory that species coexist without niche differences, without fitness differences, or with equal probability of success. Support is claimed when models lacking species differences predict highly aggregated metrics, such as species abundance distributions...

  1. Unifying the Universe the physics of heaven and earth

    CERN Document Server

    Padamsee, Hasan S

    2003-01-01

    Unifying the Universe: The Physics of Heaven and Earth provides a solid background in basic physics. With a humanistic perspective, it shows how science is significant for more than its technological consequences. The book includes clear and well-planned links to the arts and philosophies of relevant historical periods to bring science and the humanities together.

  2. Schr"odinger's Unified Field Theory: Physics by Public Relations

    Science.gov (United States)

    Halpern, Paul

    2009-05-01

    We will explore the circumstances surrounding Erwin Schr"odinger's announcement in January 1947 that he had developed a comprehensive unified field theory of gravitation and electromagnetism. We will speculate on Schr"odinger's motivations for the mode and tone of his statements, consider the reaction of the international press within the context of the postwar era, and examine Einstein's response.

  3. A Unified Analysis of Japanese Aspect Marker "te iru."

    Science.gov (United States)

    Shinzato, Rumiko

    1993-01-01

    Following Jacobson's 1990 work, this study is another attempt to offer a unified analysis of the Japanese aspect marker "te iru" that touches upon Gestalt psychologists' ideas of figure/ground opposition, Langacker's cognitive grammar, and Kunihiro's cognitive analysis. (Contains 34 references.) (LB)

  4. Annual Report 2008 -- Office of the Chief Financial Officer (OCFO)

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Jeffrey

    2008-12-22

    It is with great pleasure that I present to you the 2008 Chief Financial Officer's Annual Report. The data included in this report has been compiled from the Budget Office, the Controller, Procurement and Property Management and the Sponsored Projects Office. Also included are some financial comparisons with other DOE Laboratories and a glossary of commonly used acronyms.

  5. Effects of office innovation on office workers' health and performance

    NARCIS (Netherlands)

    Meijer, Eline M.; Frings-Dresen, Monique H. W.; Sluiter, Judith K.

    2009-01-01

    The implementation of an innovative office concept (e.g. open-plan, flexible workplaces and a paperless office concept) on health and productivity among office workers was evaluated with questionnaires of 138 workers at baseline and 6 and 15 months afterwards. Work-related fatigue, general health,

  6. El sexo de las metáforas

    Directory of Open Access Journals (Sweden)

    Pérez Sedeño, Eulalia

    2011-02-01

    Full Text Available The hypothesis that states metaphors are structurally determinant in our social relations, routines, and experience has been accepted broadly in the last decades. Moreover, metaphors are to be found in many different levels of scientific practices, and have a diverse set of functions in science. Therefore, they impregnate all scientific enterprise. In this work we examine selected gender metaphors used in biology. We show metaphors are effective precisely because its effectiveness depends on shared social conventions, kinship relations and, authority that, by convention, is given to those that use them.

    La tesis de que las metáforas estructuran gran parte de nuestras relaciones sociales y nuestra experiencia cotidiana ha sido ampliamente aceptada en las últimas décadas. En la ciencia, además, aparecen en muchos niveles y desempeñan diversas funciones, impregnando todo el quehacer científico. En este trabajo se examinan algunas metáforas de género usadas en biología. Se muestra que las metáforas eficaces lo son porque su efectividad depende de las convenciones sociales compartidas, los parecidos de familia ya vigentes y de la autoridad que, por convención, se otorga a quienes las usan.

  7. The EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma.

    Directory of Open Access Journals (Sweden)

    Steven N Steinway

    Full Text Available c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF, plays a critical role in tumor growth, invasion, and metastasis. Hepatocellular carcinoma (HCC patients with activated HGF/c-Met signaling have a significantly worse prognosis. Targeted therapies using c-Met tyrosine kinase inhibitors are currently in clinical trials for HCC, although receptor tyrosine kinase inhibition in other cancers has demonstrated early success. Unfortunately, therapeutic effect is frequently not durable due to acquired resistance.We utilized the human MHCC97-H c-Met positive (c-Met+ HCC cell line to explore the compensatory survival mechanisms that are acquired after c-Met inhibition. MHCC97-H cells with stable c-Met knockdown (MHCC97-H c-Met KD cells were generated using a c-Met shRNA vector with puromycin selection and stably transfected scrambled shRNA as a control. Gene expression profiling was conducted, and protein expression was analyzed to characterize MHCC97-H cells after blockade of the c-Met oncogene. A high-throughput siRNA screen was performed to find putative compensatory survival proteins, which could drive HCC growth in the absence of c-Met. Findings from this screen were validated through subsequent analyses.We have previously demonstrated that treatment of MHCC97-H cells with a c-Met inhibitor, PHA665752, results in stasis of tumor growth in vivo. MHCC97-H c-Met KD cells demonstrate slower growth kinetics, similar to c-Met inhibitor treated tumors. Using gene expression profiling and siRNA screening against 873 kinases and phosphatases, we identified ErbB3 and TGF-α as compensatory survival factors that are upregulated after c-Met inhibition. Suppressing these factors in c-Met KD MHCC97-H cells suppresses tumor growth in vitro. In addition, we found that the PI3K/Akt signaling pathway serves as a negative feedback signal responsible for the ErbB3 upregulation after c-Met inhibition. Furthermore, in vitro studies demonstrate that

  8. Virtuelt skrivebord med open office

    DEFF Research Database (Denmark)

    Nielsen, Kurt Gammelgaard

    2009-01-01

    SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende.......SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende....

  9. Office of Disability Employment Policy

    Science.gov (United States)

    ... STATES DEPARTMENT OF LABOR Facebook Twitter RSS Email Office of Disability Employment Policy (ODEP) Menu About ODEP ... LABOR DEPARTMENT Español A to Z Index Agencies Office of Inspector General Leadership Team Contact Us Subscribe ...

  10. The Office of Airline Information.

    Science.gov (United States)

    2015-01-01

    The Office of Airline Information (OAI) mandate is to collect, validate, compile and disseminate data on airline traffic, performance, finances, and fares. Each quarter, BTS Office of Airline Information (OAI) processes more than 3,800 filings sub...

  11. 76 FR 5276 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2011-01-31

    ... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of the... protection, Air pollution control, Incorporation by reference, Intergovernmental relations, Nitrogen dioxide...

  12. 76 FR 52623 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2011-08-23

    ... respiratory and cardiovascular disease, decreased lung function, visibility impairment, and damage to... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of...

  13. 75 FR 28509 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2010-05-21

    ..., aggravation of respiratory and cardiovascular disease, decreased lung function, visibility impairment, and... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of...

  14. 76 FR 37044 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2011-06-24

    ... premature mortality, aggravation of respiratory and cardiovascular disease, decreased lung function... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of...

  15. Ergonomics in the office environment

    Science.gov (United States)

    Courtney, Theodore K.

    1993-01-01

    Perhaps the four most popular 'ergonomic' office culprits are: (1) the computer or visual display terminal (VDT); (2) the office chair; (3) the workstation; and (4) other automated equipment such as the facsimile machine, photocopier, etc. Among the ergonomics issues in the office environment are visual fatigue, musculoskeletal disorders, and radiation/electromagnetic (VLF,ELF) field exposure from VDT's. We address each of these in turn and then review some regulatory considerations regarding such stressors in the office and general industrial environment.

  16. Is the Office Hour Obsolete?

    Science.gov (United States)

    Behrens, Susan

    2013-01-01

    A colleague can't make a coffee date at a time the author proposes because it would conflict with his office hour. No student has actually made an appointment with him during the hour, but he is committed to being in his office as promised in case someone drops by. The author's reaction to her colleague's faithfulness to his posted office hour…

  17. Fermilab Education Office: Science Adventures

    Science.gov (United States)

    Search The Education Office: Science Adventures Adventure Catalog Search for Adventures Calendar Class Facebook Group. Contact: Science Adventures Registrar, Education Office Fermilab, MS 777, P.O. Box 500 it again." Opportunities for Instructors The Education Office has openings for instructors who

  18. Assessing peak aerobic capacity in Dutch law enforcement officers

    Directory of Open Access Journals (Sweden)

    Harriet Wittink

    2015-06-01

    Full Text Available Objectives: To cross-validate the existing peak rate of oxygen consumption (VO2peak prediction equations in Dutch law enforcement officers and to determine whether these prediction equations can be used to predict VO2peak for groups and in a single individual. A further objective was to report normative absolute and relative VO2peak values of a sample of law enforcement officers in the Netherlands. Material and Methods: The peak rate of oxygen consumption (ml×kg–1×min–1 was measured using a maximal incremental bicycle test in 1530 subjects, including 1068 male and 461 female police officers. Validity of the prediction equations for groups was assessed by comparing predicted VO2peak with measured VO2peak using paired t-tests. For individual differences limits of agreement (LoA were calculated. Equations were considered valid for individuals when the difference between measured and predicted VO2peak did not exceed ±1 metabolic equivalent (MET in 95% of individuals. Results: None of the equations met the validity criterion of 95% of individuals having ±1 MET difference or less than the measured value. Limits of agreement (LoAs were large in all predictions. At the individual level, none of the equations were valid predictors of VO2peak (ml×kg–1×min–1. Normative values for Dutch law enforcement officers were presented. Conclusions: Substantial differences between measured and predicted VO2peak (ml×kg–1×min–1 were found. Most tested equations were invalid predictors of VO2peak at group level and all were invalid at individual levels.

  19. Deelname aan de samenleving van mensen met een beperking: participatiemonitor 2007.

    NARCIS (Netherlands)

    Hoogen, P. van den; Cardol, M.; Speet, M.; Spreeuwenberg, P.; Rijken, M.

    2008-01-01

    Hoe doen mensen met een beperking mee in de maatschappij? Mensen met een lichamelijke beperking wonen en werken meestal net als iedereen, en ook zij zijn niet altijd tevreden met hun werk. Mensen met een verstandelijke beperking wonen en werken vaak in een speciale omgeving. Het overheidsbeleid

  20. Office software Individual coaching

    CERN Multimedia

    HR Department

    2010-01-01

    If one or several particular topics cause you sleepless nights, you can get help from our trainer who will come to your workplace for a multiple of 1-hour slots . All fields in which our trainer can help are detailed in the course description in our training catalogue (Microsoft Office software, Adobe applications, i-applications etc.) Discover these new courses in our catalogue! http://cta.cern.ch/cta2/f?p=110:9 Technical Training Service Technical.Training@cern.ch Tel 74924

  1. Office lighting systems: Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Dagnino, U. (ENEL, Milan (Italy))

    1990-09-01

    Relative to office lighting systems, in particular, those making use of tubular fluorescent lamps, currently available on the international market, this paper tries to develop lighting system, design optimization criteria. The comparative assessment of the various design possibilities considers operating cost, energy consumption, and occupational comfort/safety aspects such as lighting level uniformity and equilibrium, reduction of glare and reflection, natural/artificial lighting balance, programmed switching, computerized control systems for multi-use requirements in large areas, programmed maintenance for greater efficiency and reliability.

  2. Building with green and glass. Innovations in the horticulture for living and working; Bouwen met groen en glas. Innovaties uit de glastuinbouw voor wonen en werken

    Energy Technology Data Exchange (ETDEWEB)

    Bergs, J.; Ter Haar, H.; Huisman, S.; Kristinsson, J.; Kruseman, I.; Oei, P.

    2007-07-01

    New technologies and insights from greenhouses, space technology and psychology are used for innovative applications in the building sector. Use is made of daylight, solar heat and vegetation. Architects can thus realize a clean, healthy and comfortable indoor climate in houses, school buildings, offices, health care centers, and also reduce the consumption of energy for cooling and heating. In particular attention is paid to the use of glass. [Dutch] Glastuinbouw, ruimtevaart en psychologie. Drie boeiende vakgebieden die op het eerste gezicht weinig met elkaar te maken hebben. Bouwen met groen en glas bewijst het tegendeel door gebruik te maken van nieuwe technieken en inzichten uit deze vakgebieden. Het concept maakt optimaal gebruik van daglicht, zonnewarmte en de weldaad van groen. Het toont de vele mogelijkheden die architecten met groen en glas kunnen aanboren. Waarom zou een architect dat doen? Omdat Bouwen met groen en glas de kern raakt van een uiterst actueel en tevens tijdloos thema: een schoon, gezond en prettig binnenklimaat in woningen, scholen, kantoren en zorginstellingen, gecombineerd met een substantieel lager energieverbruik voor koelen en verwarmen. Nieuwe technieken uit de glastuinbouw bieden nieuwe oplossingen. Bijvoorbeeld, in de zomer warmte oogsten en opslaan om die in de winter weer aan te boren. Veel glas stimuleert ook de toepassing van groen. Planten zijn meer dan versiering. Ze reinigen de lucht, zorgen voor bevochtiging en bieden mensen aangename omstandigheden om in te leren en te werken. Bouwen met groen en glas pleit dan ook voor gebouwen met een eigen ecosysteem, met planten als integraal onderdeel van het gebouw en de technische installaties.

  3. MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor.

    Science.gov (United States)

    Togashi, Yosuke; Mizuuchi, Hiroshi; Tomida, Shuta; Terashima, Masato; Hayashi, Hidetoshi; Nishio, Kazuto; Mitsudomi, Tetsuya

    2015-12-01

    MET splice site mutations resulting in an exon 14 deletion have been reported to be present in about 3% of all lung adenocarcinomas. Patients with lung adenocarcinoma and a MET splice site mutation who have responded to MET inhibitors have been reported. The CRISPR/Cas9 system is a recently developed genome-engineering tool that can easily and rapidly cause small insertions or deletions. We created an in vitro model for MET exon 14 deletion using the CRISPR/Cas9 system and the HEK293 cell line. The phenotype, which included MET inhibitor sensitivity, was then investigated in vitro. Additionally, MET splice site mutations were analyzed in several cancers included in The Cancer Genome Atlas (TCGA) dataset. An HEK293 cell line with a MET exon 14 deletion was easily and rapidly created; this cell line had a higher MET protein expression level, enhanced MET phosphorylation, and prolonged MET activation. In addition, a direct comparison of phenotypes using this system demonstrated enhanced cellular growth, colony formation, and MET inhibitor sensitivity. In the TCGA dataset, lung adenocarcinomas had the highest incidence of MET exon 14 deletions, while other cancers rarely carried such mutations. Approximately 10% of the lung adenocarcinoma samples without any of driver gene alterations carried the MET exon 14 deletion. These findings suggested that this system may be useful for experiments requiring the creation of specific mutations, and the present experimental findings encourage the development of MET-targeted therapy against lung cancer carrying the MET exon 14 deletion. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  4. Synchronization of a unified chaotic system and the application in secure communication

    International Nuclear Information System (INIS)

    Lu Junan; Wu Xiaoqun; Lue Jinhu

    2002-01-01

    This Letter further investigates the synchronization of a unified chaotic system via different methods. Several sufficient theorems for the synchronization of the unified chaotic system are deduced. A scheme of secure communication based on the synchronization of the unified chaotic system is presented. Numerical simulation shows its feasibility

  5. Performance Analysis of FSO Links over Unified Gamma-Gamma Turbulence Channels

    KAUST Repository

    Ansari, Imran Shafique; Yilmaz, Ferkan; Alouini, Mohamed-Slim

    2015-01-01

    , then, present unified exact closed-form expressions for various statistical characteristics of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system. We capitalize on these unified results to offer unified exact closed

  6. 76 FR 45212 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2011-07-28

    ... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... proposing to approve San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) Rule 3170... the environment. San Joaquin Valley Unified Air Pollution Control District SJVUAPCD is an extreme...

  7. Mastering VBA for Office 2010

    CERN Document Server

    Mansfield, Richard

    2010-01-01

    A comprehensive guide to the language used to customize Microsoft Office. Visual Basic for Applications (VBA) is the language used for writing macros, automating Office applications, and creating custom applications in Word, Excel, PowerPoint, Outlook, and Access. This complete guide shows both IT professionals and novice developers how to master VBA in order to customize the entire Office suite for specific business needs.: Office 2010 is the leading productivity suite, and the VBA language enables customizations of all the Office programs; this complete guide gives both novice and experience

  8. Teach yourself visually Office 2013

    CERN Document Server

    Marmel, Elaine

    2013-01-01

    Learn the new Microsoft Office suite the easy, visual way Microsoft Office 2013 is a power-packed suite of office productivity tools including Word, Excel, PowerPoint, Outlook, Access, and Publisher. This easy-to-use visual guide covers the basics of all six programs, with step-by-step instructions and full-color screen shots showing what you should see at each step. You'll also learn about using Office Internet and graphics tools, while the additional examples and advice scattered through the book give you tips on maximizing the Office suite. If you learn best when you can see how

  9. Deelname aan de samenleving van mensen met een beperking: participatiemonitor 2007.

    OpenAIRE

    Hoogen, P. van den; Cardol, M.; Speet, M.; Spreeuwenberg, P.; Rijken, M.

    2008-01-01

    Hoe doen mensen met een beperking mee in de maatschappij? Mensen met een lichamelijke beperking wonen en werken meestal net als iedereen, en ook zij zijn niet altijd tevreden met hun werk. Mensen met een verstandelijke beperking wonen en werken vaak in een speciale omgeving. Het overheidsbeleid is erop gericht dat iedereen – dus ook mensen met een beperking – zoveel mogelijk ‘gewoon mee kan doen’ in de maatschappij. Bijvoorbeeld werken bij een gewone werkgever, schoolgaan op een gewone school...

  10. 76 FR 5391 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director

    Science.gov (United States)

    2011-01-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science Policy, Office of the Director Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Science Advisory Board for Biosecurity (NSABB), February...

  11. Advanced CerMet ceramic composites for medical applications.

    Science.gov (United States)

    Dittmer, Robert; Schaefer, Christian M; Fischer, Jean-Francois; Hausch, Ulrich; Troetzschel, Jens; Specht, Heiko

    2017-11-01

    Implantable active devices such as pacemakers are facing rigorous requirements. Because they reside within the body for years, materials applied in this surrounding must exhibit biocompatibility and extraordinary reliability. They also have to provide a number of functional properties. In this work we present a method that enables the realization of a highly complex profile of properties by means of a dual composite approach. Using multilayer technology, an electrical conductor is embedded into a ceramic matrix, thus, creating conductive paths that are insulated from each other. In addition to this macroscopically hybrid architecture, this approach features a second composite aspect: the conductor is not composed of a single metallic phase, but is a ceramic-metal mixture. Owing to its interpenetrating microstructure, this CerMet allows for a strong and hermetic integration of the conductor into the ceramic matrix otherwise impossible due to mismatch in thermal expansion. In fact, the CerMet ceramic composite exhibits a higher strength than the pure ceramic as revealed by a three-point bending test study. At the same time, the CerMet offers high and virtually metal-like conductor properties, enabling a down-scaling of the conductive paths to 150µm diameter and smaller. Furthermore, the described composite is biocompatible, non-magnetic, and chemically inert, which is vital for the application in active, implantable, medical devices. Beside the general fabrication route, we present the microstructural, functional, and mechanical properties of this newly developed class of dual composites. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Met receptor inhibitor SU11274 localizes in the endoplasmic reticulum.

    Science.gov (United States)

    Wiest, Edwin J; Smith, Heather Jensen; Hollingsworth, Michael A

    2018-07-02

    We discovered that SU11274, a class I c-Met inhibitor, fluoresces when excited by 488 nm laser light and showed rapid specific accumulation in distinct subcellular compartments. Given that SU11274 reduces cancer cell viability, we exploited these newly identified spectral properties to determine SU11274 intracellular distribution and accumulation in human pancreatic cancer cells. The aim of the studies reported here was to identify organelle(s) to which SU11274 is trafficked. We conclude that SU11274 rapidly and predominantly accumulates in the endoplasmic reticulum. Copyright © 2018. Published by Elsevier Inc.

  13. A Comparative Study of virtual and operational met mast data

    International Nuclear Information System (INIS)

    Orhan, Dr Ö Emre; Ahmet, Gökhan

    2014-01-01

    Performance of wind assessment studies depend on the adequacy and duration of the wind data. For a reasonable wind assessment, at least one full year wind data is needed so that, all the variations throughout the year are represented. On the other hand, it is always a question of time and cost how to get the wind data. On-site measurements are the most common way of obtaining wind data but it is the most expensive and time consuming as well. Apart from onsite data, there are also reanalysis long term data sources like MERRA, NCAR, etc. Time and spatial resolution of these long term data are lower compared to on-site measurements but in cases where on-site measurements are not available, they are also utilized. On top of on-site and reanalysis wind data, weather forecasting models like WRF, MM5 are available. Although, these models mainly are used for forecasting services, flexibility of the models makes them suitable for preliminary resource assessment purposes. In this study, comparisons of annual energy production estimations are computed using virtual and on-site met mast data separately for a specific time range. The widely used weather research and forecasting model (WRF) is used to provide virtual met mast data. Once WRF simulations are completed, interpolation routines are employed in order to extract data for a specific location. The on-site met mast is located inside a wind farm project area which is under development. Project site is located in the south of Turkey. There are four different met masts, three of them recording wind data presently. On-site measurements together with WRF results are used to obtain energy yields for the project area. The performance of both methodologies is compared. It has been observed that WRF can as well serve as a preliminary model in cases where no other data source is available but the model has to be implemented with great care depending on the project site conditions

  14. Alkaline transition of pseudoazurin Met16X mutant proteins: protein stability influenced by the substitution of Met16 in the second sphere coordination.

    Science.gov (United States)

    Abdelhamid, Rehab F; Obara, Yuji; Kohzuma, Takamitsu

    2008-01-01

    Several blue copper proteins are known to change the active site structure at alkaline pH (alkaline transition). Spectroscopic studies of Met16Phe, Met16Tyr, Met16Trp, and Met16Val pseudoazurin variants were performed to investigate the second sphere role through alkaline transition. The visible electronic absorption and resonance Raman spectra of Met16Phe, Met16Tyr, and Met16Trp variants showed the increasing of axial component at pH approximately 11 like wild-type PAz. The visible electronic absorption and far-UV CD spectra of Met16Val demonstrated that the destabilization of the protein structure was triggered at pH>11. Resonance Raman (RR) spectra of PAz showed that the intensity-weighted averaged Cu-S(Cys) stretching frequency was shifted to higher frequency region at pH approximately 11. The higher frequency shift of Cu-S(Cys) bond is implied the stronger Cu-S(Cys) bond at alkaline transition pH approximately 11. The visible electronic absorption and far-UV CD spectra of Met16X PAz revealed that the Met16Val variant is denatured at pH>11, but Met16Phe, Met16Tyr, and Met16Trp mutant proteins are not denatured even at pH>11. These observations suggest that Met16 is important to maintain the protein structure through the possible weak interaction between methionine -SCH3 part and coordinated histidine imidazole moiety. The introduction of pi-pi interaction in the second coordination sphere may be contributed to the enhancement of protein structure stability.

  15. A first-in-human phase I study of SAR125844, a selective MET tyrosine kinase inhibitor, in patients with advanced solid tumours with MET amplification.

    Science.gov (United States)

    Angevin, Eric; Spitaleri, Gianluca; Rodon, Jordi; Dotti, Katia; Isambert, Nicolas; Salvagni, Stefania; Moreno, Victor; Assadourian, Sylvie; Gomez, Corinne; Harnois, Marzia; Hollebecque, Antoine; Azaro, Analia; Hervieu, Alice; Rihawi, Karim; De Marinis, Filippo

    2017-12-01

    Dysregulated MET signalling is implicated in oncogenesis. The safety and preliminary efficacy of a highly selective MET kinase inhibitor (SAR125844) was investigated in patients with advanced solid tumours and MET dysregulation. This was a phase I dose-escalation (3 + 3 design [50-740 mg/m 2 ]) and dose-expansion study. In the dose escalation, patients had high total MET (t-MET) expression by immunohistochemistry (IHC) or MET amplification by fluorescence in situ hybridisation. In the dose expansion, patients had MET amplification (including a subset of patients with non-small cell lung cancer [NSCLC]) or phosphorylated-MET (p-MET) expression (IHC). Objectives were determination of maximum tolerated dose (MTD) of once-weekly intravenous SAR125844 based on dose-limiting toxicities; safety and pharmacokinetic profile; preliminary efficacy of SAR125844 MTD in the expansion cohort. In total, 72 patients were enrolled: dose escalation, N = 33; dose expansion, N = 39; 570 mg/m 2 was established as the MTD. Most frequent treatment-emergent adverse events (AEs) were asthenia/fatigue (58.3%), nausea (31.9%), and abdominal pain, constipation, and dyspnea (27.8% for each); 58.3% of patients reported grade 3 AEs (19.4% were treatment related). Of the 29 evaluable patients with MET amplification treated at 570 mg/m 2 , five achieved a partial response, including four of 22 with NSCLC; 17 patients had stable disease. No response was observed in patients with high p-MET solid tumours. There was no correlation between tumour response and t-MET status or MET gene copy number. The MTD of once-weekly SAR125844 was 570 mg/m 2 ; SAR125844 was well tolerated, with significant antitumour activity in patients with MET-amplified NSCLC. NCT01391533. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  16. The Unified Database for BM@N experiment data handling

    Science.gov (United States)

    Gertsenberger, Konstantin; Rogachevsky, Oleg

    2018-04-01

    The article describes the developed Unified Database designed as a comprehensive relational data storage for the BM@N experiment at the Joint Institute for Nuclear Research in Dubna. The BM@N experiment, which is one of the main elements of the first stage of the NICA project, is a fixed target experiment at extracted Nuclotron beams of the Laboratory of High Energy Physics (LHEP JINR). The structure and purposes of the BM@N setup are briefly presented. The article considers the scheme of the Unified Database, its attributes and implemented features in detail. The use of the developed BM@N database provides correct multi-user access to actual information of the experiment for data processing. It stores information on the experiment runs, detectors and their geometries, different configuration, calibration and algorithm parameters used in offline data processing. An important part of any database - user interfaces are presented.

  17. Rational Unified Process jako metodika vývoje softwaru

    OpenAIRE

    Rytíř, Vladimír

    2008-01-01

    Cílem této práce je seznámit se s procesem vývoje softwaru dle vybraných metodik s hlavním zaměřením na metodiku Rational Unified Process od firmy IBM. Incepční a elaborační fáze této metody také aplikuji na praktickém  příkladě. Goal of my work is to introduce software development process metods specialized to Rational Unified Process metod from IBM. I aplicate inception and elaboration phases of RUP on practical example. B

  18. Hyperion technology enables unified meteorological and radiological monitoring

    International Nuclear Information System (INIS)

    Zigic, A.; Saponjic, D.; Arandjelovic, V.; Zunic, Z. . E-mail address of corresponding author: alex@vin.bg.ac.yu; Zigic, A.)

    2005-01-01

    The present state of meteorological and radiological measurement and monitoring are quite localized to smaller areas which implies the difficulties in knowing the measurement results in the wider region instantly. The need for establishing a distributed, flexible, modular and centralized measurement system for both meteorological and radiological parameters of environment is arising. The measurement and monitoring of radiological parameters of environment are not sufficient since there is a strong correlation between radiological and meteorological parameters which implies a unified distributed automatic monitoring system. The unified monitoring system makes it possible to transfer, process and store measured data in local and central databases. Central database gives a possibility of easy access to all measured data for authorized personnel and institutions. Stored measured data in central database gives a new opportunity to create a base for meteorological and radiological modelling and studies. (author)

  19. Transcultural nursing as a global care humanizer, diversifier, and unifier.

    Science.gov (United States)

    Leininger, M M

    1997-01-01

    Three dominant themes of transcultural nursing as a global humanizer, diversifier, and unifier are discussed in relation to their meaning and uses in education, practice, research and consultation. The presenter takes the position that these three dominant themes are essential and imperative to promote, transform, and maintain desired care outcomes which are beneficial, satisfying, and healthy for people of diverse and similar cultures. The three themes are discussed within Leininger's theory of Culture Care Diversity and Universality with focus on the modes of action and decision-making. The author encourages transcultural nurses to take leadership to be an active global humanizer, diversifier, and unifier and transform nursing and health care into the 21st century.

  20. Unified dark fluid in Brans-Dicke theory

    International Nuclear Information System (INIS)

    Tripathy, Sunil K.; Behera, Dipanjali; Mishra, Bivudutta

    2015-01-01

    Anisotropic dark energy cosmological models are constructed in the frame work of generalised Brans-Dicke theory with a self-interacting potential. A unified dark fluid characterised by a linear equation of state is considered as the source of dark energy. The shear scalar is considered to be proportional to the expansion scalar simulating an anisotropic relationship among the directional expansion rates. The dynamics of the universe in the presence of a unified dark fluid in anisotropic background have been discussed. The presence of an evolving scalar field makes it possible to get an accelerating phase of expansion even for a linear relationship among the directional Hubble rates. It is found that the anisotropy in expansion rates does not affect the scalar field, the self-interacting potential, but it controls the non-evolving part of the Brans-Dicke parameter. (orig.)

  1. Research and Design in Unified Coding Architecture for Smart Grids

    Directory of Open Access Journals (Sweden)

    Gang Han

    2013-09-01

    Full Text Available Standardized and sharing information platform is the foundation of the Smart Grids. In order to improve the dispatching center information integration of the power grids and achieve efficient data exchange, sharing and interoperability, a unified coding architecture is proposed. The architecture includes coding management layer, coding generation layer, information models layer and application system layer. Hierarchical design makes the whole coding architecture to adapt to different application environments, different interfaces, loosely coupled requirements, which can realize the integration model management function of the power grids. The life cycle and evaluation method of survival of unified coding architecture is proposed. It can ensure the stability and availability of the coding architecture. Finally, the development direction of coding technology of the Smart Grids in future is prospected.

  2. A unified treatment of kinetic effects in a tokamak pedestal

    International Nuclear Information System (INIS)

    Catto, Peter J; Landreman, Matt; Kagan, Grigory; Pusztai, Istvan

    2011-01-01

    We consider the effects of a finite pedestal radial electric field on ion orbits using a unified approach. We then employ these modified orbit results to retain finite E x B drift departures from flux surfaces in an improved drift-kinetic equation. The procedure allows us to make a clear distinction between transit averages and flux surface averages when solving this kinetic equation. The technique outlined here is intended to clarify and unify recent evaluations of the banana regime decrease and plateau regime alterations in the ion heat diffusivity; the reduction and possible reversal of the poloidal flow in the banana regime, and its augmentation in the plateau regime; the increase in the bootstrap current; and the enhancement of the residual zonal flow regulation of turbulence.

  3. Onset of the nonlinear regime in unified dark matter models

    International Nuclear Information System (INIS)

    Avelino, P.P.; Beca, L.M.G.; Carvalho, J.P.M. de; Martins, C.J.A.P.; Copeland, E.J.

    2004-01-01

    We discuss the onset of the nonlinear regime in the context of unified dark matter models involving a generalized Chaplygin gas. We show that the transition from dark-matter-like to dark-energy-like behavior will never be smooth. In some regions of space the transition will never take place while in others it may happen sooner or later than naively expected. As a result the linear theory used in previous studies may break down late in the matter dominated era even on large cosmological scales. We study the importance of this effect showing that its magnitude depends on the exact form of the equation of state in the low density regime. We expect that our results will be relevant for other unified dark matter scenarios, particularly those where the quartessence candidate is a perfect fluid

  4. High energy behaviour of particles and unified statistics

    International Nuclear Information System (INIS)

    Chang, Y.

    1984-01-01

    Theories and experiments suggest that particles at high energy appear to possess a new statistics unifying Bose-Einstein and Fermi-Dirac statistics via the GAMMA distribution. This hypothesis can be obtained from many models, and agrees quantitatively with scaling, the multiplicty, large transverse momentum, the mass spectrum, and other data. It may be applied to scatterings at high energy, and agrees with experiments and known QED's results. The Veneziano model and other theories have implied new statistics, such as, the B distribution and the Polya distribution. They revert to the GAMMA distribution at high energy. The possible inapplicability of Pauli's exclusion principle within the unified statistics is considered and associated to the quark constituents

  5. Reduction of parameters in Finite Unified Theories and the MSSM

    Science.gov (United States)

    Heinemeyer, Sven; Mondragón, Myriam; Tracas, Nicholas; Zoupanos, George

    2018-02-01

    The method of reduction of couplings developed by W. Zimmermann, combined with supersymmetry, can lead to realistic quantum field theories, where the gauge and Yukawa sectors are related. It is the basis to find all-loop Finite Unified Theories, where the β-function vanishes to all-loops in perturbation theory. It can also be applied to the Minimal Supersymmetric Standard Model, leading to a drastic reduction in the number of parameters. Both Finite Unified Theories and the reduced MSSM lead to successful predictions for the masses of the third generation of quarks and the Higgs boson, and also predict a heavy supersymmetric spectrum, consistent with the non-observation of supersymmetry so far.

  6. Low-energy neutral current phenomenology and grand unified theories

    International Nuclear Information System (INIS)

    Del Aguila, F.; Mendez, A.

    1981-01-01

    We derive necessary and sufficient conditions to be satisfied by any expanded electroweak gauge model in order to reproduce the standard model low-energy neutral current predictions. These conditions imply several constraints on the neutral gauge boson masses and the quantum number assignments for the ordinary fermions. Using these conditions, we prove that the popular grand unified theories based on the gauge groups SO(10) and E6 can only accommodate trivial extensions of the standard model. As a consequence, if any of these grand unified models works at some energy scale, present low-energy neutral current phenomenology implies that the Z-boson must be produced with the expected mass and couplings to the ordinary fermions. Any additional neutral gauge boson (with the possible exception of very heavy ones) could only be produced in hadronic collisions and it would not decay in e + e - . (orig.)

  7. Constructal Law and the Unifying Principle of Design

    CERN Document Server

    Lorente, Sylvie; Bejan, Adrian

    2013-01-01

    Design happens everywhere, whether in animate objects (e.g., dendritic lung structures, bacterial colonies, and corals), inanimate patterns (river basins, beach slope, and dendritic crystals), social dynamics (pedestrian traffic flows), or engineered systems (heat dissipation in electronic circuitry). This “design in nature” often takes on remarkably similar patterns, which can be explained under one unifying Constructal Law. This book explores the unifying power of the Constructal Law and its applications in all domains of design generation and evolution, ranging from biology and geophysics to globalization, energy, sustainability, and security.  The Constructal Law accounts for the universal tendency of flow systems to morph into evolving configurations that provide greater and easier access over time. The Constructal Law resolves the many and contradictory ad hoc statements of “optimality”, end design, and destiny in nature, such as minimum and maximum entropy production and minimum and maximum fl...

  8. Unified Digital Periodic Signal Filters for Power Converter Systems

    DEFF Research Database (Denmark)

    Yang, Yongheng; Xin, Zhen; Zhou, Keliang

    2017-01-01

    Periodic signal controllers like repetitive and resonant controllers have demonstrated much potential in the control of power electronic converters, where periodic signals (e.g., ac voltages and currents) can be precisely regulated to follow references. Beyond the control of periodic signals, ac...... signal processing (e.g., in synchronization and pre-filtering) is also very important for power converter systems. Hence, this paper serves to unify digital periodic signal filters so as to maximize their roles in power converter systems (e.g., enhance the control of ac signals). The unified digital...... periodic signal filters behave like a comb filter, but it can also be configured to selectively filter out the harmonics of interest (e.g., the odd-order harmonics in single-phase power converter systems). Moreover, a virtual variable-sampling-frequency unit delay that enables frequency adaptive periodic...

  9. Modeling Enterprise Authorization: A Unified Metamodel and Initial Validation

    Directory of Open Access Journals (Sweden)

    Matus Korman

    2016-07-01

    Full Text Available Authorization and its enforcement, access control, have stood at the beginning of the art and science of information security, and remain being crucial pillar of security in the information technology (IT and enterprises operations. Dozens of different models of access control have been proposed. Although Enterprise Architecture as the discipline strives to support the management of IT, support for modeling access policies in enterprises is often lacking, both in terms of supporting the variety of individual models of access control nowadays used, and in terms of providing a unified ontology capable of flexibly expressing access policies for all or the most of the models. This study summarizes a number of existing models of access control, proposes a unified metamodel mapped to ArchiMate, and illustrates its use on a selection of example scenarios and two business cases.

  10. La metáfora como proceso cognitivo

    Directory of Open Access Journals (Sweden)

    Luz Amparo Fajardo Uribe

    2006-01-01

    Full Text Available La metáfora es un mecanismo que hace posible conceptualizar y reconceptualizar el mundo a partir de la traslación de rasgos de un dominio de origen a un dominio de llegada. En esa medida, la metáfora no necesita inventar nuevos términos para referirse a la realidad, sino que a partir de los ya existentes brinda una visión diferente de ésta en tanto que ha sido enriquecida con la afectividad y la emotividad del sujeto cognoscente. Por esa razón, la comprensión y producción metafórica requiere más de la competencia comunicativa que de la competencia lingüística, dado que el sentido que éste adopta depende del contexto comunicativo y no de la constitución léxica, morfológica sintáctica del enunciado.

  11. DiPS: A Unifying Approach for developing System Software

    OpenAIRE

    Michiels, Sam; Matthijs, Frank; Walravens, Dirk; Verbaeten, Pierre

    2002-01-01

    In this paper we unify three essential features for flexible system software: a component oriented approach, self-adaptation and separation of concerns.We propose DiPS (Distrinet Protocol Stack), a component framework, which offers components, an anonymous interaction model and connectors to handle non-functional aspects such as concurrency. DiPS has effectively been used in industrial protocol stacks and device drivers.

  12. Skinner-Rusk unified formalism for higher-order systems

    Science.gov (United States)

    Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso

    2012-07-01

    The Lagrangian-Hamiltonian unified formalism of R. Skinner and R. Rusk was originally stated for autonomous dynamical systems in classical mechanics. It has been generalized for non-autonomous first-order mechanical systems, first-order and higher-order field theories, and higher-order autonomous systems. In this work we present a generalization of this formalism for higher-order non-autonomous mechanical systems.

  13. Flavor unifying schemes with a single fermionic representation

    International Nuclear Information System (INIS)

    Davidson, A.; Wali, K.C.

    1980-05-01

    If quarks and leptons are indeed elementary, it is natural that they belong to a single representation of a unifying group, G. It is shown that such a requirement, which is inconsistent with G = SU(N), can be satisfied within the semi-simple group G = SU(N) x SU(N). Furthermore, N = 7 emerges as the unique solution accompanied by a fermionic set that exhibits a natural generation structure

  14. Multiple growth regimes: Insights from unified growth theory

    OpenAIRE

    Galor, Oded

    2007-01-01

    Unified Growth Theory uncovers the forces that contributed to the existence of multiple growth regimes and the emergence of convergence clubs. It suggests that differential timing of take-offs from stagnation to growth segmented economies into three fundamental regimes: slow growing economies in a Malthusian regime, fast growing countries in a sustained growth regime, and economies in the transition between these regimes. In contrast to existing research that links regime switching thresholds...

  15. A Unified Access Model for Interconnecting Heterogeneous Wireless Networks

    Science.gov (United States)

    2015-05-01

    validation of the proposed network design for unified network access, and it lays the foundation for implementing a Software - Defined Networking ( SDN ...York (NY): Springer; 2014. Chapter 2, Software - defined networking ; p. 19–32. 5. Sharma S, Staessens D, Colle D, Pickavet M, Demeester P. A...demonstration of fast failure recovery in software defined networking . In: Korakis T, Zink M, Ott, M, editors. Testbeds and research infrastructure

  16. The Unified Problem-Solving Method Development Language UPML

    OpenAIRE

    Fensel, Dieter; Motta, Enrico; van Harmelen, Frank; Benjamins, V. Richard; Crubezy, Monica; Decker, Stefan; Gaspari, Mauro; Groenboom, Rix; Grosso, William; Musen, Mark; Plaza, Enric; Schreiber, Guus; Studer, Rudi; Wielinga, Bob

    2003-01-01

    Problem-solving methods provide reusable architectures and components for implementing the reasoning part of knowledge-based systems. The UNIFIED PROBLEM-SOLVING METHOD DESCRIPTION LANGUAGE (UPML) has been developed to describe and implement such architectures and components to facilitate their semi-automatic reuse and adaptation. In a nutshell, UPML is a framework for developing knowledge-intensive reasoning systems based on libraries ofg eneric problem-solving components. The paper describe...

  17. Split Octonion electrodynamics and unified fields of dyons

    International Nuclear Information System (INIS)

    Bisht, P.S.

    2004-01-01

    Split octonion electrodynamics has been developed in terms of Zorn's vector matrix realization by reformulating electromagnetic potential, current, field tensor and other dynamical quantities. Corresponding field equation (Unified Maxwell's equations) and equation of motion have been reformulated by means of split octonion and its Zorn vector realization in unique, simpler and consistent manner. It has been shown that this theory reproduces the dyon field equations in the absence of gravito-dyons and vice versa

  18. Unified Facilities Criteria (UFC) Design Guide. Army Reserve Facilities

    Science.gov (United States)

    2010-02-01

    horticulturally appropriate to the site specific location in which they are planted. Consideration should be given to adjacent structures and improvements...impact FPI Federal Prison Industries FPM Feet per minute GFCI Government-furnished/contractor-installed or Ground-Fault Circuit Interrupter GFGI...Uniform Federal Accessibility Standards UFGs Unified Facility Guide Specifications UFGs Rst UFGS - Reserve Support Team UnICoR Federal Prison Industry

  19. Chaos synchronization of a unified chaotic system via partial linearization

    International Nuclear Information System (INIS)

    Yu Yongguang; Li Hanxiong; Duan Jian

    2009-01-01

    A partial linearization method is proposed for realizing the chaos synchronization of an unified chaotic system. Through synchronizing partial state of the chaotic systems can result in the synchronization of their entire states, and the resulting controller is singularity free. The results can be easily extended to the synchronization of other similar chaotic systems. Simulation results are conducted to show the effectiveness of the method.

  20. Radiative breaking of cosmologically acceptable grand unified theories

    International Nuclear Information System (INIS)

    Gato, B.; Leon, J.; Quiros, M.

    1984-01-01

    We present a cosmologically acceptable grand unified model where the breaking of SU(5) proceeds through radiative corrections induced by supergravity soft-breaking terms. The breaking scale is determined by dimensional transmutation. The model is compatible with the radiative breaking of SU(2)sub(L)xU(1)sub(Y) which provides an experimentally accessible low energy particle spectrum and small top quark mass. (orig.)

  1. Z2 vortex strings in grand unified theories

    International Nuclear Information System (INIS)

    Olive, D.; Turok, N.

    1982-01-01

    Spontaneously broken gauge theories may display distinct vortex string solutions for the disconnected components of the exact gauge symmetry group. A type of Higgs mechanism thought to apply in grand unified theories as being responsible for fermion masses yields Z 2 vortex lines, irrespectively of the group. These could seed galaxy formation if the corresponding fermion masses are superheavy. More generally a Higgs mechanism producing Zsub(n) vortex strings is presented. (orig.)

  2. A unified BFKL/DGLAP description of deep inelastic scattering

    International Nuclear Information System (INIS)

    Kwiecinski, J.; Stasto, A. M.; Martin, A. D.

    1997-01-01

    We introduce a coupled pair of evolution equations for the unintegrated gluon distribution and the sea quark distribution which incorporate both the resummed leading ln(1/x) BFKL contributions and the resummed leading ln(Q 2 ) DGLAP contributions. We solve these unified equations in the perturbative QCD domain. With only two physically motivated parameters we obtain an excellent description of the HERA F 2 data

  3. Globalization and migration: A "unified brain drain" model

    OpenAIRE

    Brezis, Elise S.; Soueri, Ariel

    2012-01-01

    Globalization has led to a vast flow of migration of workers but also of students. The purpose of this paper is to analyze the migration of individuals encompassing decisions already at the level of education. We develop a unified brain drain model that incorporates the decisions of an individual vis - à - vis both education and migration. In the empirical part, this paper addresses international flows of migration within the EU and presents strong evidence of concentration of students in cou...

  4. Configuration Control Office

    CERN Multimedia

    Beltramello, O

    In order to enable Technical Coordination to manage the detector configuration and to be aware of all changes in this configuration, a baseline of the envelopes has been created in April 2001. Fifteen system and multi-system envelope drawings have been approved and baselined. An EDMS file is associated with each approved envelope, which provides a list of the current known unsolved conflicts related to the envelope and a list of remaining drawing inconsistencies to be corrected. The envelope status with the associated drawings and EDMS file can be found on the web at this adress: http://atlasinfo.cern.ch/Atlas/TCOORD/Activities/Installation/Configuration/ Any modification in the baseline has to be requested via the Engineering Change Requests. The procedure can be found under: http://atlasinfo.cern.ch/Atlas/TCOORD/Activities/TcOffice/Quality/ECR/ TC will review all the systems envelopes in the near future and manage conflict resolution with the collaboration of the systems.

  5. Badge Office Process Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Haurykiewicz, John Paul [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dinehart, Timothy Grant [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Parker, Robert Young [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-12

    The purpose of this process analysis was to analyze the Badge Offices’ current processes from a systems perspective and consider ways of pursuing objectives set forth by SEC-PS, namely increased customer flow (throughput) and reduced customer wait times. Information for the analysis was gathered for the project primarily through Badge Office Subject Matter Experts (SMEs), and in-person observation of prevailing processes. Using the information gathered, a process simulation model was constructed to represent current operations and allow assessment of potential process changes relative to factors mentioned previously. The overall purpose of the analysis was to provide SEC-PS management with information and recommendations to serve as a basis for additional focused study and areas for potential process improvements in the future.

  6. INEL Sample Management Office

    International Nuclear Information System (INIS)

    Watkins, C.

    1994-01-01

    The Idaho National Engineering Laboratory (INEL) Sample Management Office (SMO) was formed as part of the EG ampersand G Idaho Environmental Restoration Program (ERP) in June, 1990. Since then, the SMO has been recognized and sought out by other prime contractors and programs at the INEL. Since December 1991, the DOE-ID Division Directors for the Environmental Restoration Division and Waste Management Division supported the expansion of the INEL ERP SMO into the INEL site wide SMO. The INEL SMO serves as a point of contact for multiple environmental analytical chemistry and laboratory issues (e.g., capacity, capability). The SMO chemists work with project managers during planning to help develop data quality objectives, select appropriate analytical methods, identify special analytical services needs, identify a source for the services, and ensure that requirements for sampling and analysis (e.g., preservations, sample volumes) are clear and technically accurate. The SMO chemists also prepare work scope statements for the laboratories performing the analyses

  7. Physician offices marketing: assessing patients' views of office visits.

    Science.gov (United States)

    Emmett, Dennis; Chandra, Ashish

    2010-01-01

    Physician offices often lack the sense of incorporating appropriate strategies to make their facilities as marketer of their services. The patient experience at a physician's office not only incorporates the care they receive from the physician but also the other non-healthcare related aspects, such as the behavior of non-health professionals as well as the appearance of the facility itself. This paper is based on a primary research conducted to assess what patients assess from a physician office visit.

  8. The office based CHIVA

    Directory of Open Access Journals (Sweden)

    Passariello F

    2013-09-01

    Full Text Available Fausto Passariello,1 Stefano Ermini,2 Massimo Cappelli,3 Roberto Delfrate,4 Claude Franceschi5 1Centro Diagnostico Aquarius, Napoli, Italy; 2Private Practice, Grassina, Italy; 3Private Practice, Firenze, Italy; 4Casa di Cure Figlie di Maria, Cremona, Italy; 5Hospital St Joseph, Service d'Explorations Vasculaires, Paris, France Abstract: The cure Conservatrice Hémodynamique de l'Insuffisance Veineuse en Ambulatoire (CHIVA can be office based (OB. The OB-CHIVA protocol is aimed at transferring CHIVA procedures to specialists rooms. The protocol will check the feasibility of OB-CHIVA, data pertaining to recurrence, and will offer the opportunity to study saphenous femoral junction (SFJ stump evolution, the role of the washing vessels and the arch recanalization rate, and gather new data about the effect of the length of the treated saphenous vein. A simplified diagnostic procedure will allow an essential ultrasound examination of the venous net while a schematic and easily readable algorithm guides therapeutic choices. The Riobamba draining crossotomy (RDC tactic is composed of a set of OB procedures. While some of these procedures are, at the moment, only proposals, others are already applied. Devices generally used in ablative procedures such as Light Amplification by Stimulated Emission of Radiation (LASER, radio frequency, steam, and mechanical devices are used in this context to serve to conservative interventions for CHIVA. New techniques have also been proposed for devalvulation and tributary disconnection. Detailed follow-up is necessary in order to determine the effects of therapy and possible disease evolution. Finally, information is added about the informed consent and the ethical considerations of OB-CHIVA research. Keywords: CHIVA, office based procedures, LASER, RF, steam

  9. Unified Stochastic Geometry Model for MIMO Cellular Networks with Retransmissions

    KAUST Repository

    Afify, Laila H.

    2016-10-11

    This paper presents a unified mathematical paradigm, based on stochastic geometry, for downlink cellular networks with multiple-input-multiple-output (MIMO) base stations (BSs). The developed paradigm accounts for signal retransmission upon decoding errors, in which the temporal correlation among the signal-to-interference-plus-noise-ratio (SINR) of the original and retransmitted signals is captured. In addition to modeling the effect of retransmission on the network performance, the developed mathematical model presents twofold analysis unification for MIMO cellular networks literature. First, it integrates the tangible decoding error probability and the abstracted (i.e., modulation scheme and receiver type agnostic) outage probability analysis, which are largely disjoint in the literature. Second, it unifies the analysis for different MIMO configurations. The unified MIMO analysis is achieved by abstracting unnecessary information conveyed within the interfering signals by Gaussian signaling approximation along with an equivalent SISO representation for the per-data stream SINR in MIMO cellular networks. We show that the proposed unification simplifies the analysis without sacrificing the model accuracy. To this end, we discuss the diversity-multiplexing tradeoff imposed by different MIMO schemes and shed light on the diversity loss due to the temporal correlation among the SINRs of the original and retransmitted signals. Finally, several design insights are highlighted.

  10. Inverted Unified Power Quality Conditioner to compensate overvoltage

    Directory of Open Access Journals (Sweden)

    Yeison Alberto Garcés Gómez

    2017-07-01

    Full Text Available Introduction: The use of unified power quality conditioners UPQC in the electric systems can correct waveform distortions in a steady state, like harmonics, flicker, and the power factor. Objective: This paper presents a novel approach for active compensation of overvoltage with a UPQC in dual topology or iUPQC. Methodology: The study it is presented in five stages, the section I shows an introduction and the state of the art, section II presents the unified power quality conditioner UPQC, section III describes the generalized reactive power theory applied to the iUPQC (dual topology, section IV shows the numerical simulations and the results and section V presents the conclusions of the study. Results: The results for the application of the iUPQC to the compensation of overvoltage are proved and compared with the more representative theory related to compensation of harmonics and low power factor. Conclusions: The control algorithm presented for the unified power quality conditioner in dual topology allows to compensate the overvoltage in three-phase systems as well as voltage and current harmonics and the low power factor.

  11. Unified Stochastic Geometry Model for MIMO Cellular Networks with Retransmissions

    KAUST Repository

    Afify, Laila H.; Elsawy, Hesham; Al-Naffouri, Tareq Y.; Alouini, Mohamed-Slim

    2016-01-01

    This paper presents a unified mathematical paradigm, based on stochastic geometry, for downlink cellular networks with multiple-input-multiple-output (MIMO) base stations (BSs). The developed paradigm accounts for signal retransmission upon decoding errors, in which the temporal correlation among the signal-to-interference-plus-noise-ratio (SINR) of the original and retransmitted signals is captured. In addition to modeling the effect of retransmission on the network performance, the developed mathematical model presents twofold analysis unification for MIMO cellular networks literature. First, it integrates the tangible decoding error probability and the abstracted (i.e., modulation scheme and receiver type agnostic) outage probability analysis, which are largely disjoint in the literature. Second, it unifies the analysis for different MIMO configurations. The unified MIMO analysis is achieved by abstracting unnecessary information conveyed within the interfering signals by Gaussian signaling approximation along with an equivalent SISO representation for the per-data stream SINR in MIMO cellular networks. We show that the proposed unification simplifies the analysis without sacrificing the model accuracy. To this end, we discuss the diversity-multiplexing tradeoff imposed by different MIMO schemes and shed light on the diversity loss due to the temporal correlation among the SINRs of the original and retransmitted signals. Finally, several design insights are highlighted.

  12. United States Army Officer Professional Development: Black Officers' Perspectives

    National Research Council Canada - National Science Library

    Johnson, Craig

    1997-01-01

    .... Even so, they have not fared statistically as well as their majority contemporaries. These statistics pose interesting questions about black officer professional development and career progress...

  13. Higher Levels of c-Met Expression and Phosphorylation Identify Cell Lines With Increased Sensitivity to AMG-458, a Novel Selective c-Met Inhibitor With Radiosensitizing Effects

    International Nuclear Information System (INIS)

    Li Bo; Torossian, Artour; Sun, Yunguang; Du, Ruihong; Dicker, Adam P.; Lu Bo

    2012-01-01

    Purpose: c-Met is overexpressed in some non-small cell lung cancer (NSCLC) cell lines and tissues. Cell lines with higher levels of c-Met expression and phosphorylation depend on this receptor for survival. We studied the effects of AMG-458 on 2 NSCLC cell lines. Methods and Materials: 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl) -2H-tetrazolium assays assessed the sensitivities of the cells to AMG-458. Clonogenic survival assays illustrated the radiosensitizing effects of AMG-458. Western blot for cleaved caspase 3 measured apoptosis. Immunoblotting for c-Met, phospho-Met (p-Met), Akt/p-Akt, and Erk/p-Erk was performed to observe downstream signaling. Results: AMG-458 enhanced radiosensitivity in H441 but not in A549. H441 showed constitutive phosphorylation of c-Met. A549 expressed low levels of c-Met, which were phosphorylated only in the presence of exogenous hepatocyte growth factor. The combination of radiation therapy and AMG-458 treatment was found to synergistically increase apoptosis in the H441 cell line but not in A549. Radiation therapy, AMG-458, and combination treatment were found to reduce p-Akt and p-Erk levels in H441 but not in A549. H441 became less sensitive to AMG-458 after small interfering RNA knockdown of c-Met; there was no change in A549. After overexpression of c-Met, A549 became more sensitive, while H441 became less sensitive to AMG-458. Conclusions: AMG-458 was more effective in cells that expressed higher levels of c-Met/p-Met, suggesting that higher levels of c-Met and p-Met in NSCLC tissue may classify a subset of tumors that are more sensitive to molecular therapies against this receptor.

  14. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Science.gov (United States)

    2010-10-01

    ... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the authority... 49 Transportation 7 2010-10-01 2010-10-01 false Delegation to the Directors of Office of Aviation...

  15. Implications of a Non-Unified Command System and the Need for a Unified Command System in Zambia

    Science.gov (United States)

    2015-06-12

    aspects. It has been found that Zambia’s two attempts to unify its system happened during the one party participatory democracy era. Since the coming...and its Implication for Democracy ,” in Ourselves to Know: Civil Military Relations and Defence Transformation in Southern Africa, eds. Rocky Williams...adopted a multiparty system of government under the Movement for Multi-Party Democracy (MMD) which decided to revert to independent commands. As

  16. PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells

    International Nuclear Information System (INIS)

    Crosswell, Hal E; Dasgupta, Anindya; Alvarado, Carlos S; Watt, Tanya; Christensen, James G; De, Pradip; Durden, Donald L; Findley, Harry W

    2009-01-01

    c-Met is a tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), and both c-Met and its ligand are expressed in a variety of tissues. C-Met/HGF/SF signaling is essential for normal embryogenesis, organogenesis, and tissue regeneration. Abnormal c-Met/HGF/SF signaling has been demonstrated in different tumors and linked to aggressive and metastatic tumor phenotypes. In vitro and in vivo studies have demonstrated inhibition of c-Met/HGF/SF signaling by the small-molecule inhibitor PHA665752. This study investigated c-Met and HGF expression in two neuroblastoma (NBL) cell lines and tumor tissue from patients with NBL, as well as the effects of PHA665752 on growth and motility of NBL cell lines. The effect of the tumor suppressor protein PTEN on migration and proliferation of tumor cells treated with PHA665752 was also evaluated. Expression of c-Met and HGF in NBL cell lines SH-EP and SH-SY5Y and primary tumor tissue was assessed by immunohistochemistry and quantitative RT-PCR. The effect of PHA665752 on c-Met/HGF signaling involved in NBL cell proliferation and migration was evaluated in c-Met-positive cells and c-Met-transfected cells. The transwell chemotaxis assay and the MTT assay were used to measure migration and proliferation/cell-survival of tumor cells, respectively. The PPAR-γ agonist rosiglitazone was used to assess the effect of PTEN on PHA665752-induced inhibition of NBL cell proliferation/cell-survival and migration High c-Met expression was detected in SH-EP cells and primary tumors from patients with advanced-stage disease. C-Met/HGF signaling induced both migration and proliferation of SH-EP cells. Migration and proliferation/cell-survival were inhibited by PHA665752 in a dose-dependent manner. We also found that induced overexpression of PTEN following treatment with rosiglitazone significantly enhanced the inhibitory effect of PHA665752 on NBL-cell migration and proliferation. c-Met is highly expressed in most tumors from

  17. Becoming an Officer of Consequence

    Science.gov (United States)

    2007-01-01

    ndupress .ndu.edu   issue 44, 1st quarter 2007  /  JFQ        6 Becoming an officer of Consequence m uch of the literature about military history...commander become officers of consequence because their commanders value their judgment and seek their counsel when making difficult choices...COVERED 00-00-2007 to 00-00-2007 4. TITLE AND SUBTITLE Becoming an Officer of Consequence 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM

  18. Battlefield Electromagnetic Environments Office (BEEO)

    Data.gov (United States)

    Federal Laboratory Consortium — The Battlefield Electromagnetic Environments Office (BEEO) develops, maintains, and operates the Army Materiel Command (AMC) databases for spectrum management, per...

  19. Metallography at the Met Lab -- The first fifty years

    International Nuclear Information System (INIS)

    Lee, R.H.

    1995-01-01

    The Met Lab at the University of Chicago was established to build the world's first nuclear reactor. The object was to see if a pile (CP-1) could be built to create a sustained chain reaction, i.e., controlled nuclear fission. New materials of the very best quality were needed and people of many skills worked together to achieve the goal as quickly as possible. This is the story of a select group of people who were scientific and engineering pioneers in this new field. Research continued at new sites on more advanced reactors and cooling systems. Many problems were encountered in the fabrication of reactor components, and metallography was a crucial method of analyzing the reactions and quality of consolidation. 1996 will be the 50th anniversary of the beginning of the National Laboratories, so it is appropriate to commemorate and recall some pioneering achievements

  20. The MeteoMet2 project—highlights and results

    Science.gov (United States)

    Merlone, A.; Sanna, F.; Beges, G.; Bell, S.; Beltramino, G.; Bojkovski, J.; Brunet, M.; del Campo, D.; Castrillo, A.; Chiodo, N.; Colli, M.; Coppa, G.; Cuccaro, R.; Dobre, M.; Drnovsek, J.; Ebert, V.; Fernicola, V.; Garcia-Benadí, A.; Garcia-Izquierdo, C.; Gardiner, T.; Georgin, E.; Gonzalez, A.; Groselj, D.; Heinonen, M.; Hernandez, S.; Högström, R.; Hudoklin, D.; Kalemci, M.; Kowal, A.; Lanza, L.; Miao, P.; Musacchio, C.; Nielsen, J.; Nogueras-Cervera, M.; Oguz Aytekin, S.; Pavlasek, P.; de Podesta, M.; Rasmussen, M. K.; del-Río-Fernández, J.; Rosso, L.; Sairanen, H.; Salminen, J.; Sestan, D.; Šindelářová, L.; Smorgon, D.; Sparasci, F.; Strnad, R.; Underwood, R.; Uytun, A.; Voldan, M.

    2018-02-01

    Launched in 2011 within the European Metrology Research Programme (EMRP) of EURAMET, the joint research project ‘MeteoMet’—Metrology for Meteorology—is the largest EMRP consortium; national metrology institutes, universities, meteorological and climate agencies, research institutes, collaborators and manufacturers are working together, developing new metrological techniques, as well as improving existing ones, for use in meteorological observations and climate records. The project focuses on humidity in the upper and surface atmosphere, air temperature, surface and deep-sea temperatures, soil moisture, salinity, permafrost temperature, precipitation, and the snow albedo effect on air temperature. All tasks are performed using a rigorous metrological approach and include the design and study of new sensors, new calibration facilities, the investigation of sensor characteristics, improved techniques for measurements of essential climate variables with uncertainty evaluation, traceability, laboratory proficiency and the inclusion of field influencing parameters, long-lasting measurements, and campaigns in remote and extreme areas. The vision for MeteoMet is to take a step further towards establishing full data comparability, coherency, consistency, and long-term continuity, through a comprehensive evaluation of the measurement uncertainties for the quantities involved in the global climate observing systems and the derived observations. The improvement in quality of essential climate variables records, through the inclusion of measurement uncertainty budgets, will also highlight possible strategies for the reduction of the uncertainty. This contribution presents selected highlights of the MeteoMet project and reviews the main ongoing activities, tasks and deliverables, with a view to its possible future evolution and extended impact.