WorldWideScience

Sample records for met lab section

  1. History of Met Lab Section C-I, May 1943 to April 1944

    Energy Technology Data Exchange (ETDEWEB)

    Seaborg, G.T.

    1978-05-01

    This is part of a history of the research work of Seaborg and associates in the University of Chicago Metallurgical Laboratory, Chemistry Section C-I. The work was concerned with the development of chemical procedures for the extraction of plutonium, for the purification of plutonium, and for research on the isotopes of other heavy elements including other transuranium elements. The style of the history is that of a diary with footnotes giving additional information. (DLC)

  2. History of Met Lab Section C-I, May 1943 to April 1944

    International Nuclear Information System (INIS)

    Seaborg, G.T.

    1978-05-01

    This is part of a history of the research work of Seaborg and associates in the University of Chicago Metallurgical Laboratory, Chemistry Section C-I. The work was concerned with the development of chemical procedures for the extraction of plutonium, for the purification of plutonium, and for research on the isotopes of other heavy elements including other transuranium elements. The style of the history is that of a diary with footnotes giving additional information

  3. History of Met Lab Section C-I, May 1945 to May 1946

    Energy Technology Data Exchange (ETDEWEB)

    Seaborg, G.T.

    1980-06-01

    This is the final volume of a history of the research work of Seaborg and associates in the University of Chicago Metallurgical Laboratory, Chemistry Section C-1. The work was concerned with the development of chemical procedures for the extraction of plutonium, for the purification of plutonium and, in the later phases, for research on the isotopes of other heavy elements including other transuranium elements. The style of the history is that of a diary with footnotes giving additional information.

  4. History of Met Lab Section C-I, May 1945 to May 1946

    International Nuclear Information System (INIS)

    Seaborg, G.T.

    1980-06-01

    This is the final volume of a history of the research work of Seaborg and associates in the University of Chicago Metallurgical Laboratory, Chemistry Section C-1. The work was concerned with the development of chemical procedures for the extraction of plutonium, for the purification of plutonium and, in the later phases, for research on the isotopes of other heavy elements including other transuranium elements. The style of the history is that of a diary with footnotes giving additional information

  5. Remembering the early days of the Met Lab

    International Nuclear Information System (INIS)

    Katz, J.J.

    1990-01-01

    The Met Lab was set up by the war-time Manhattan District, US Corp of Engineers to (i) find a system using normal uranium in which a chain reaction would occur; (ii) to show that if such a chain reaction did occur, it would be possible to separate plutonium chemically from the uranium matrix and the fission products formed in the chain reactions; and (iii) to prepare plans for the large-scale production of plutonium. Chemistry Section C-1 of the Met Lab was assigned the responsibility for developing separation methods for plutonium production on the industrial scale. This report describes some aspects of daily life in Section C-1

  6. Metallography at the Met Lab -- The first fifty years

    International Nuclear Information System (INIS)

    Lee, R.H.

    1995-01-01

    The Met Lab at the University of Chicago was established to build the world's first nuclear reactor. The object was to see if a pile (CP-1) could be built to create a sustained chain reaction, i.e., controlled nuclear fission. New materials of the very best quality were needed and people of many skills worked together to achieve the goal as quickly as possible. This is the story of a select group of people who were scientific and engineering pioneers in this new field. Research continued at new sites on more advanced reactors and cooling systems. Many problems were encountered in the fabrication of reactor components, and metallography was a crucial method of analyzing the reactions and quality of consolidation. 1996 will be the 50th anniversary of the beginning of the National Laboratories, so it is appropriate to commemorate and recall some pioneering achievements

  7. From big data analysis in the cloud to robotic pot drumming: tales from the Met Office Informatics Lab

    Science.gov (United States)

    Robinson, Niall; Tomlinson, Jacob; Prudden, Rachel; Hilson, Alex; Arribas, Alberto

    2017-04-01

    The Met Office Informatics Lab is a small multidisciplinary team which sits between science, technology and design. Our mission is simply "to make Met Office data useful" - a deliberately broad objective. Our prototypes often trial cutting edge technologies, and so far have included projects such as virtual reality data visualisation in the web browser, bots and natural language interfaces, and artificially intelligent weather warnings. In this talk we focus on our latest project, Jade, a big data analysis platform in the cloud. It is a powerful, flexible and simple to use implementation which makes extensive use of technologies such as Jupyter, Dask, containerisation, Infrastructure as Code, and auto-scaling. Crucially, Jade is flexible enough to be used for a diverse set of applications: it can present weather forecast information to meteorologists and allow climate scientists to analyse big data sets, but it is also effective for analysing non-geospatial data. As well as making data useful, the Informatics Lab also trials new working practises. In this presentation, we will talk about our experience of making a group like the Lab successful.

  8. Metallurgical Laboratory (MetLab) Treatability Study: An Analysis of Passive Soil Vapor Extraction Wells (PSVE) FY1999 Update; ANNUAL

    International Nuclear Information System (INIS)

    Riha, B.D.

    1999-01-01

    The results to date on the treatability study of the PSVE system at the MetLab of the Savannah River Site (SRS) indicate the technology is performing well. Well concentrations are decreasing and contour maps of the vadose zone soil gas plume show a decrease in the extent of the plume. In the 18 months of operation approximately 200 pounds of chlorinated organic contaminants have been removed by natural barometric pumping of wells fitted with BaroBall valves (low pressure check valves). The mass removal estimates are approximate since the flow rates are estimated, the concentration data is based on exponential fits of a limited data set, and the concentration data is normalized to the average CO2.The concentration values presented in this report should be taken as the general trend or order of magnitude of concentration until longer-term data is collected. These trends are of exponentially decreasing concentration showing the same characteristics as the concentration trends at the SRS Miscellaneous Chemical Basin after three years of PSVE (Riha et. al., 1999)

  9. WheelerLab: An interactive program for sequence stratigraphic analysis of seismic sections, outcrops and well sections and the generation of chronostratigraphic sections and dynamic chronostratigraphic sections

    Science.gov (United States)

    Amosu, Adewale; Sun, Yuefeng

    WheelerLab is an interactive program that facilitates the interpretation of stratigraphic data (seismic sections, outcrop data and well sections) within a sequence stratigraphic framework and the subsequent transformation of the data into the chronostratigraphic domain. The transformation enables the identification of significant geological features, particularly erosional and non-depositional features that are not obvious in the original seismic domain. Although there are some software products that contain interactive environments for carrying out chronostratigraphic analysis, none of them are open-source codes. In addition to being open source, WheelerLab adds two important functionalities not present in currently available software: (1) WheelerLab generates a dynamic chronostratigraphic section and (2) WheelerLab enables chronostratigraphic analysis of older seismic data sets that exist only as images and not in the standard seismic file formats; it can also be used for the chronostratigraphic analysis of outcrop images and interpreted well sections. The dynamic chronostratigraphic section sequentially depicts the evolution of the chronostratigraphic chronosomes concurrently with the evolution of identified genetic stratal packages. This facilitates a better communication of the sequence-stratigraphic process. WheelerLab is designed to give the user both interactive and interpretational control over the transformation; this is most useful when determining the correct stratigraphic order for laterally separated genetic stratal packages. The program can also be used to generate synthetic sequence stratigraphic sections for chronostratigraphic analysis.

  10. WheelerLab: An interactive program for sequence stratigraphic analysis of seismic sections, outcrops and well sections and the generation of chronostratigraphic sections and dynamic chronostratigraphic sections

    Directory of Open Access Journals (Sweden)

    Adewale Amosu

    2017-01-01

    Full Text Available WheelerLab is an interactive program that facilitates the interpretation of stratigraphic data (seismic sections, outcrop data and well sections within a sequence stratigraphic framework and the subsequent transformation of the data into the chronostratigraphic domain. The transformation enables the identification of significant geological features, particularly erosional and non-depositional features that are not obvious in the original seismic domain. Although there are some software products that contain interactive environments for carrying out chronostratigraphic analysis, none of them are open-source codes. In addition to being open source, WheelerLab adds two important functionalities not present in currently available software: (1 WheelerLab generates a dynamic chronostratigraphic section and (2 WheelerLab enables chronostratigraphic analysis of older seismic data sets that exist only as images and not in the standard seismic file formats; it can also be used for the chronostratigraphic analysis of outcrop images and interpreted well sections. The dynamic chronostratigraphic section sequentially depicts the evolution of the chronostratigraphic chronosomes concurrently with the evolution of identified genetic stratal packages. This facilitates a better communication of the sequence-stratigraphic process. WheelerLab is designed to give the user both interactive and interpretational control over the transformation; this is most useful when determining the correct stratigraphic order for laterally separated genetic stratal packages. The program can also be used to generate synthetic sequence stratigraphic sections for chronostratigraphic analysis.

  11. History of MET Lab Section C-I, April 1942--April 1943

    International Nuclear Information System (INIS)

    Seaborg, G.T.

    1977-02-01

    A day-to-day account of the work done at the University of Chicago Metallurgical Laboratory from April 1942 to April 1943 is given. The work concerned the development of chemical procedures for the extraction of plutonium, for the purification of plutonium, and, in the later phases, for research on the isotopes of other heavy elements including other transuranium elements

  12. History of MET Lab Section C-I, April 1942--April 1943

    Energy Technology Data Exchange (ETDEWEB)

    Seaborg, G.T.

    1977-02-01

    A day-to-day account of the work done at the University of Chicago Metallurgical Laboratory from April 1942 to April 1943 is given. The work concerned the development of chemical procedures for the extraction of plutonium, for the purification of plutonium, and, in the later phases, for research on the isotopes of other heavy elements including other transuranium elements. (LK)

  13. WheelerLab: An interactive program for sequence stratigraphic analysis of seismic sections, outcrops and well sections and the generation of chronostratigraphic sections and dynamic chronostratigraphic sections

    OpenAIRE

    Adewale Amosu; Yuefeng Sun

    2017-01-01

    WheelerLab is an interactive program that facilitates the interpretation of stratigraphic data (seismic sections, outcrop data and well sections) within a sequence stratigraphic framework and the subsequent transformation of the data into the chronostratigraphic domain. The transformation enables the identification of significant geological features, particularly erosional and non-depositional features that are not obvious in the original seismic domain. Although there are some software produ...

  14. Rust Contamination from Water Leaks in the Cosmic Dust Lab and Lunar and Meteorite Thin Sections Labs at Johnson Space Center

    Science.gov (United States)

    Kent, J. J.; Berger, E. L.; Fries, M. D.; Bastien, R.; McCubbin, F. M.; Pace, L.; Righter, K.; Sutter, B.; Zeigler, R. A.; Zolensky, M.

    2017-01-01

    On the early morning of September 15th, 2016, on the first floor of Building 31 at NASA-Johnson Space Center, the hose from a water chiller ruptured and began spraying water onto the floor. The water had been circulating though old metal pipes, and the leaked water contained rust-colored particulates. The water flooded much of the western wing of the building's ground floor before the leak was stopped, and it left behind a residue of rust across the floor, most notably in the Apollo and Meteorite Thin Section Labs and Sample Preparation Lab. No samples were damaged in the event, and the affected facilities are in the process of remediation. At the beginning of 2016, a separate leak occurred in the Cosmic Dust Lab, located in the same building. In that lab, a water leak occurred at the bottom of the sink used to clean the lab's tools and containers with ultra-pure water. Over years of use, the ultra-pure water eroded the metal sink piping and leaked water onto the inside of the lab's flow bench. This water also left behind a film of rusty material. The material was cleaned up and the metal piping was replaced with PVC pipe and sealed with Teflon plumber's tape. Samples of the rust detritus were collected from both incidents. These samples were imaged and analyzed to determine their chemical and mineralogical compositions. The purpose of these analyses is to document the nature of the detritus for future reference in the unlikely event that these materials occur as contaminants in the Cosmic Dust samples or Apollo or Meteorite thin sections.

  15. Measurement of Compton scattering cross section during PrimEx-II Experiment at Jefferson Lab

    Science.gov (United States)

    Ye, Li; PrimEx Collaboration

    2017-09-01

    The electron Compton scattering is the most known fundamental QED process, however, a precision measurement of its cross section for the beam energy above 1 GeV has been lacking up to now. An updated high precision measurement of the neutral pion lifetime via the Primakoff effect (PrimEx-II) experiment was performed in Hall B of Jefferson Lab in 2010. The experiment used small angle coherent photoproduction of π0's in the Coulomb field of a nucleus, i.e. the Primakoff effect, to determine the lifetime with a precision of less than 1.5 % . It therefore requires thorough understanding of the underlying systematic uncertainties. To facilitate that data for well known electromagnetic processes were taken concurrently with the photoproduction data. This analysis pertains to measuring the Compton scattering cross section, which occurs at similar kinematics as the primary process. The combination of the well established theory of this process with large collected statistics allowed to extract this cross section with high precision in an energy region of 4-5 GeV for 12C and 28Si targets. The results of this analysis will be presented. This work is supported in part by the U.S. Department of Energy under Contacts No. DE-FG02-03ER41528, NSF MRI PHY-0079840, Thomas Jefferson National Laboratory, Mississippi State University and PrimEx collaboration.

  16. Differential cross section and recoil polarization measurements for the gamma p to K+ Lambda reaction using CLAS at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    McCracken, Michael E. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2010-02-01

    We present measurements of the differential cross section and Lambda recoil polarization for the gamma p to K+ Lambda reaction made using the CLAS detector at Jefferson Lab. These measurements cover the center-of-mass energy range from 1.62 to 2.84 GeV and a wide range of center-of-mass K+ production angles. Independent analyses were performed using the K+ p pi- and K+ p (missing pi -) final-state topologies; results from these analyses were found to exhibit good agreement. These differential cross section measurements show excellent agreement with previous CLAS and LEPS results and offer increased precision and a 300 MeV increase in energy coverage. The recoil polarization data agree well with previous results and offer a large increase in precision and a 500 MeV extension in energy range. The increased center-of-mass energy range that these data represent will allow for independent study of non-resonant K+ Lambda photoproduction mechanisms at all production angles.

  17. The Science Teaching Self-Efficacy of Prospective Elementary Education Majors Enrolled in Introductory Geology Lab Sections

    Science.gov (United States)

    Baldwin, Kathryn A.

    2014-01-01

    This study examined prospective elementary education majors' science teaching self-efficacy while they were enrolled in an introductory geology lab course for elementary education majors. The Science Teaching Efficacy Belief Instrument Form B (STEBI-B) was administered during the first and last lab class sessions. Additionally, students were…

  18. Vision Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Vision Lab personnel perform research, development, testing and evaluation of eye protection and vision performance. The lab maintains and continues to develop...

  19. Advanced LabVIEW Labs

    International Nuclear Information System (INIS)

    Jones, Eric D.

    1999-01-01

    In the world of computer-based data acquisition and control, the graphical interface program LabVIEW from National Instruments is so ubiquitous that in many ways it has almost become the laboratory standard. To date, there have been approximately fifteen books concerning LabVIEW, but Professor Essick's treatise takes on a completely different tack than all of the previous discussions. In the more standard treatments of the ways and wherefores of LabVIEW such as LabVIEW Graphical Programming: Practical Applications in Instrumentation and Control by Gary W. Johnson (McGraw Hill, NY 1997), the emphasis has been instructing the reader how to program LabVIEW to create a Virtual Instrument (VI) on the computer for interfacing to a particular instruments. LabVIEW is written in ''G'' a graphical programming language developed by National Instruments. In the past the emphasis has been on training the experimenter to learn ''G''. Without going into details here, ''G'' incorporates the usual loops, arithmetic expressions, etc., found in many programming languages, but in an icon (graphical) environment. The net result being that LabVIEW contains all of the standard methods needed for interfacing to instruments, data acquisition, data analysis, graphics, and also methodology to incorporate programs written in other languages into LabVIEW. Historically, according to Professor Essick, he developed a series of experiments for an upper division laboratory course for computer-based instrumentation. His observation was that while many students had the necessary background in computer programming languages, there were students who had virtually no concept about writing a computer program let alone a computer- based interfacing program. Thus the beginnings of a concept for not only teaching computer- based instrumentation techniques, but aiso a method for the beginner to experience writing a com- puter program. Professor Essick saw LabVIEW as the ''perfect environment in which to

  20. Estimating the met need for emergency obstetric care (EmOC) services in three payams of Torit County, South Sudan: a facility-based, retrospective cross-sectional study

    Science.gov (United States)

    Bayo, Pontius; Itua, Imose; Francis, Suzie Paul; Boateng, Kofi; Tahir, Elijo Omoro; Usman, Abdulmumini

    2018-01-01

    Objective To determine the met need for emergency obstetric care (EmOC) services in three Payams of Torit County, South Sudan in 2015 and to determine the frequency of each major obstetric complication. Design This was a retrospective cross-sectional study. Setting Four primary healthcare centres (PHCCs) and one state hospital in three payams (administrative areas that form a county) in Torit County, South Sudan. Participants All admissions in the obstetrics and gynaecology wards (a total of 2466 patient admission files) in 2015 in all the facilities designated to conduct deliveries in the study area were reviewed to identify obstetric complications. Primary and secondary outcome measures The primary outcome was met need for EmOC, which was defined as the proportion of all women with direct major obstetric complications in 2015 treated in health facilities providing EmOC services. The frequency of each complication and the interventions for treatment were the secondary outcomes. Results Two hundred and fifty four major obstetric complications were admitted in 2015 out of 390 expected from 2602 pregnancies, representing 65.13% met need. The met need was highest (88%) for Nyong Payam, an urban area, compared with the other two rural payams, and 98.8% of the complications were treated from the hospital, while no complications were treated from three PHCCs. The most common obstetric complications were abortions (45.7%), prolonged obstructed labour (23.2%) and haemorrhage (16.5%). Evacuation of the uterus for retained products (42.5%), caesarean sections (32.7%) and administration of oxytocin for treatment of postpartum haemorrhage (13.3%) were the most common interventions. Conclusion The met need for EmOC in Torit County is low, with 35% of women with major obstetric complications not accessing care, and there is disparity with Nyong Payam having a higher met need. We suggest more support supervision to the PHCCs to increase access for the rural population. PMID

  1. Estimating the met need for emergency obstetric care (EmOC) services in three payams of Torit County, South Sudan: a facility-based, retrospective cross-sectional study.

    Science.gov (United States)

    Bayo, Pontius; Itua, Imose; Francis, Suzie Paul; Boateng, Kofi; Tahir, Elijo Omoro; Usman, Abdulmumini

    2018-02-14

    To determine the met need for emergency obstetric care (EmOC) services in three Payams of Torit County, South Sudan in 2015 and to determine the frequency of each major obstetric complication. This was a retrospective cross-sectional study. Four primary healthcare centres (PHCCs) and one state hospital in three payams (administrative areas that form a county) in Torit County, South Sudan. All admissions in the obstetrics and gynaecology wards (a total of 2466 patient admission files) in 2015 in all the facilities designated to conduct deliveries in the study area were reviewed to identify obstetric complications. The primary outcome was met need for EmOC, which was defined as the proportion of all women with direct major obstetric complications in 2015 treated in health facilities providing EmOC services. The frequency of each complication and the interventions for treatment were the secondary outcomes. Two hundred and fifty four major obstetric complications were admitted in 2015 out of 390 expected from 2602 pregnancies, representing 65.13% met need. The met need was highest (88%) for Nyong Payam, an urban area, compared with the other two rural payams, and 98.8% of the complications were treated from the hospital, while no complications were treated from three PHCCs. The most common obstetric complications were abortions (45.7%), prolonged obstructed labour (23.2%) and haemorrhage (16.5%). Evacuation of the uterus for retained products (42.5%), caesarean sections (32.7%) and administration of oxytocin for treatment of postpartum haemorrhage (13.3%) were the most common interventions. The met need for EmOC in Torit County is low, with 35% of women with major obstetric complications not accessing care, and there is disparity with Nyong Payam having a higher met need. We suggest more support supervision to the PHCCs to increase access for the rural population. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All

  2. An Approach for WebLabs Analysis

    Directory of Open Access Journals (Sweden)

    Javier García Zubia

    2007-05-01

    Full Text Available The Faculty of Engineering of University of Deusto has a WebLab oriented to Microelectronics available since 2001. The first part of this paper shows several requirements that a WebLab should meet and the following sections present the WebLab-Deusto.

  3. Precisielandbouw komt met golven

    NARCIS (Netherlands)

    Schans, van der D.A.

    2009-01-01

    Met deze laatste golf van vernieuwing zijn we dicht bij het op grote schaal toepassen van prescisielandbouw gekomen. We kunnen beelden digitaal uitwisselen met bedrijfsmanagementprogramma's en kunnen ze op het perceel projecteren

  4. Deeply virtual compton scattering on the nucleon with the Clas Detector of Jefferson Lab: measurement of the polarized and unpolarized cross sections; Etude de la diffusion compton profondement virtuelle sur le nucleon avec le detecteur Clas de Jefferson Lab: mesure des sections efficaces polarisees et non polarisees

    Energy Technology Data Exchange (ETDEWEB)

    Jo, H.S

    2007-03-15

    The Generalized Parton Distributions (GPDs), introduced in the 1990's, provide the most complete description of the structure (in quarks and gluons) of the nucleon. The Deeply Virtual Compton Scattering (DVCS), which corresponds to the 'hard' exclusive electroproduction of photons on the nucleon, is a key process among the reactions allowing access to the GPDs. A DVCS-dedicated experiment was carried out in 2005 with the CLAS detector of Jefferson Lab, using a polarized electron beam of 5.776 GeV and a hydrogen target. For this experiment, we built and used a dedicated electromagnetic calorimeter capable of detecting the final-state photon. The collected data allowed us to study the DVCS in the widest kinematic range ever accessed for this reaction: 1 < Q{sup 2} < 4.6 GeV{sup 2}, 0.1 < x{sub B} < 0.58, 0.09 < -t < 2 GeV{sup 2}. The work performed during this PhD includes simulation work done for the preparation of the experiment, timing calibration of one of the CLAS subsystems, and data analysis. The aim of the data analysis was the extraction of the unpolarized cross sections of the studied reaction and of the difference of the polarized cross sections, this latter observable being linearly proportional to the GPDs. The obtained results were compared to DVCS theoretical calculations based on one of the most up-to-date GPD parametrizations. (author)

  5. Basic rules of hygiene protect health care and lab workers from nasal colonization by Staphylococcus aureus: an international cross-sectional study.

    Directory of Open Access Journals (Sweden)

    Mitra Saadatian-Elahi

    Full Text Available Acquisition of nasal Staphylococcus aureus (S. aureus colonization by contaminated hands is likely an important determinant of its nasal carriage rate in health care and lab setting. The objective of our cross-sectional study was to assess the prevalence of nasal methicillin-sensitive (MSSA or -resistant Staphylococcus aureus (MRSA carriage among health care professionals (HCPs attending an international symposium and to study the association between compliance with hygiene rules, individual-related parameters, and medical conditions with nasal S. aureus carriage in this population. After obtaining consent, two nasal swabs were collected. Nasal MSSA and MRSA carriage was measured by the: i molecular approach targeting spa, mecA and mecA-orfX junction sequences, and ii culture on selective S. aureus media combined with mecA molecular detection of isolated strains. Information on compliance with hygiene rules, demographic variables, sector of activity and long-term medication was collected by anonymous questionnaire. The participation rate was 32.3%. In total, 176 subjects from 34 countries were included in the analysis. S. aureus was isolated from the nasal swabs of 57 (32.4% subjects, of whom 3 (5.3% harbored MRSA strains. Overall, 123 subjects reported working in microbiology laboratories with direct manipulation of S. aureus, and 29 acknowledged regular contacts with patients. In this exposed population, hydro-alcoholic solutions appeared to have a significant protective effect against nasal S. aureus carriage (OR = 0.36; 95% CI: 0.15-0.85. Hospital work was associated with increased risk of nasal S. aureus carriage (OR = 2.38; 95% CI: 1.07-5.29. The results of this study showed that compliance with basic rules of hygiene, such as the use of hydro-alcoholic solutions, could reduce the risk of nasal S. aureus colonization. Hydro-alcoholic solution could interrupt auto-transmission of the pathogen, consequently decreasing the overall

  6. When Historiography Met Epistemology

    Directory of Open Access Journals (Sweden)

    Jean-François Stoffel

    2017-06-01

    Full Text Available Review of Bordoni, Stefano. When historiography met epistemology: Sophisticated histories and philosophies of science in French-speaking countries in the second half of the nineteenth century. Reviewed by Jean-François Stoffel.

  7. Autorijden met ADHD

    NARCIS (Netherlands)

    Fuermaier, Anselm B.M.; Tucha, Lara; de Vries, Stefanie M.; Koerts, Janneke; de Waard, Dick; Brookhuis, Karel; Tucha, Oliver

    Volwassenen met attention deficit hyperactivity disorder (ADHD) hebben uiteenlopende cognitieve beperkingen, die een aanzienlijke invloed kunnen hebben op verschillende aspecten van het dagelijks leven. Een van deze aspecten is het besturen van een auto. Autorijden is een belangrijke activiteit in

  8. Lindebladwespen bestrijd met geel

    NARCIS (Netherlands)

    Linden, van der A.

    2005-01-01

    De lindebladwesp (Caliros annulipes) komt in verschillende boomsoorten voor en is een lastig te bestrijden plaaginsect. PPO Bomen ontdekte dat de bladwesp goed te bestrijden is met behulp van gele signaalplaten

  9. Living Labs als een Vehikel voor (Onderwijs)innovatie

    NARCIS (Netherlands)

    Ellen Sjoer

    2014-01-01

    Wereldwijd schieten ze als paddenstoelen uit de grond: living labs. Deze ‘levende laboratoria’ zijn er in alle soorten en maten. Meestal wordt het lab gezien als een onderzoeks- en ontwikkelomgeving om een probleem met verschillende partijen op een innovatieve manier op te lossen. De thema’s van de

  10. Incorporating a Career Planning Lab into a Managerial Communications Course

    Science.gov (United States)

    May, Gary L.

    2005-01-01

    This article describes how a small business school, as part of a strategic planning initiative to improve career services, added a self-directed career planning lab to an existing managerial communication course. The lab concept and the learning design are innovative because they met a student need without creating additional time demands on the…

  11. Teachers' Perspectives on Online Virtual Labs vs. Hands-On Labs in High School Science

    Science.gov (United States)

    Bohr, Teresa M.

    This study of online science teachers' opinions addressed the use of virtual labs in online courses. A growing number of schools use virtual labs that must meet mandated laboratory standards to ensure they provide learning experiences comparable to hands-on labs, which are an integral part of science curricula. The purpose of this qualitative case study was to examine teachers' perceptions of the quality and effectiveness of high school virtual labs. The theoretical foundation was constructivism, as labs provide student-centered activities for problem solving, inquiry, and exploration of phenomena. The research questions focused on experienced teachers' perceptions of the quality of virtual vs. hands-on labs. Data were collected through survey questions derived from the lab objectives of The Next Generation Science Standards . Eighteen teachers rated the degree of importance of each objective and also rated how they felt virtual labs met these objectives; these ratings were reported using descriptive statistics. Responses to open-ended questions were few and served to illustrate the numerical results. Many teachers stated that virtual labs are valuable supplements but could not completely replace hands-on experiences. Studies on the quality and effectiveness of high school virtual labs are limited despite widespread use. Comprehensive studies will ensure that online students have equal access to quality labs. School districts need to define lab requirements, and colleges need to specify the lab experience they require. This study has potential to inspire positive social change by assisting science educators, including those in the local school district, in evaluating and selecting courseware designed to promote higher order thinking skills, real-world problem solving, and development of strong inquiry skills, thereby improving science instruction for all high school students.

  12. Onderhandelen met Hamas?

    NARCIS (Netherlands)

    Boekestijn, A.J.

    2006-01-01

    Volgens de Wetenschappelijke Raad voor het Regeringsbeleid is de terroristische organisatie Hamas geleidelijk aan het moderniseren. De WRR vindt dan ook dat het Westen zonder condities vooraf met deze organisatie moet gaan praten. Onze regering wil pas onderhandelen indien Hamas geweld afzweert en

  13. SPSS met syntax

    NARCIS (Netherlands)

    Grotenhuis, H.F. te; Visscher, C.A.M.

    2007-01-01

    Dit boekje wijkt af van de gebruikelijke statistiekboeken omdat het sec gaat over het bekende statistische computerprogramma SPSS, en dan alleen nog de oorspronkelijke variant waarin wordt gewerkt met syntax (intypen commando's -zoals bij DOS) i.p.v. de later ontwikkelde 'Windows-schil' (aanklikken

  14. Virtual Reality Lab Assistant

    Science.gov (United States)

    Saha, Hrishikesh; Palmer, Timothy A.

    1996-01-01

    Virtual Reality Lab Assistant (VRLA) demonstration model is aligned for engineering and material science experiments to be performed by undergraduate and graduate students in the course as a pre-lab simulation experience. This will help students to get a preview of how to use the lab equipment and run experiments without using the lab hardware/software equipment. The quality of the time available for laboratory experiments can be significantly improved through the use of virtual reality technology.

  15. Met kerse op met -konstruksies 1 : 'n Verwysingspuntperspektief ...

    African Journals Online (AJOL)

    Met kerse op met-konstruksies1: 'n Verwysingspuntperspektief. Johanna Messerschmidt, Luna Bergh. Abstract. This article analyses the usage of the Afrikaans preposition met ('with'). The analysis is done within the framework of Cognitive Linguistics and more specifically within the model proposed by Langacker (1993) ...

  16. The Telecom Lab is moving

    CERN Multimedia

    IT Department

    2009-01-01

    As of 2nd March 2009, the Telecom Lab will move to Building 58 R-017. The Telecom Lab is the central point for all support questions regarding CERN mobile phone services (provision of SIM cards, requests for modifications of subscriptions, diagnostics for mobile phone problems, etc.). The opening hours as well as the contact details for the Telecom Lab remain unchanged: New location: Building 58 R-017 Opening hours: Every week day, from 11 a.m. to 12 a.m. Phone number: 72480 Email address: labo.telecom@cern.ch This change has no impact on support requests for mobile services. Users can still submit their requests concerning mobile phone subscriptions using the usual EDH form (https://edh.cern.ch/Document/GSM). The automatic message sent to inform users of their SIM card availability will be updated to indicate the new Telecom Lab location. You can find all information related to CERN mobile phone services at the following link: http://cern.ch/gsm CS Section - IT/CS group

  17. Crystallization Formulation Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Crystallization Formulation Lab fills a critical need in the process development and optimization of current and new explosives and energetic formulations. The...

  18. USNA DIGITAL FORENSICS LAB

    Data.gov (United States)

    Federal Laboratory Consortium — To enable Digital Forensics and Computer Security research and educational opportunities across majors and departments. Lab MissionEstablish and maintain a Digital...

  19. Fabrication and Prototyping Lab

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose: The Fabrication and Prototyping Lab for composite structures provides a wide variety of fabrication capabilities critical to enabling hands-on research and...

  20. Magnetic Media Lab

    Data.gov (United States)

    Federal Laboratory Consortium — This lab specializes in tape certification and performance characterization of high density digital tape and isprepared to support the certification of standard size...

  1. Guidelines for Urban Labs

    DEFF Research Database (Denmark)

    Scholl, Christian; Agger Eriksen, Mette; Baerten, Nik

    2017-01-01

    urban lab initiatives from five different European cities: Antwerp (B), Graz and Leoben (A), Maastricht (NL) and Malmö (S). We do not pretend that these guidelines touch upon all possible challenges an urban lab may be confronted with, but we have incorporated all those we encountered in our...

  2. OpenLabNotes

    DEFF Research Database (Denmark)

    List, Markus; Franz, Michael; Tan, Qihua

    2015-01-01

    be advantageous if an ELN was Integrated with a laboratory information management system to allow for a comprehensive documentation of experimental work including the location of samples that were used in a particular experiment. Here, we present OpenLabNotes, which adds state-of-the-art ELN capabilities to Open......LabFramework, a powerful and flexible laboratory information management system. In contrast to comparable solutions, it allows to protect the intellectual property of its users by offering data protection with digital signatures. OpenLabNotes effectively Closes the gap between research documentation and sample management...

  3. Plaagrups te lijf met seksferomoon

    NARCIS (Netherlands)

    Bouter, H.; Griepink, F.C.

    2006-01-01

    Onderzoekers van Plant Research International kunnen het seksferomoon van het plaaginsect Duponchelia fovealis namaken. Telers van onder andere potplanten en paprika kunnen met deze lokstof veel gewasschade voorkomen

  4. LabVIEW Support at CERN

    CERN Multimedia

    HR Department

    2010-01-01

    Since the beginning of 2009, due to the CERN restructuring, LabVIEW support moved from the IT to the EN department, joining the Industrial Controls and Electronics Group (ICE). LabVIEW support has been merged with the Measurement, Test and Analysis (MTA) section which, using LabVIEW, has developed most of the measurement systems to qualify the LHC magnets and components over the past 10 years. The post mortem analysis for the LHC hardware commissioning has also been fully implemented using LabVIEW, customised into a framework, called RADE, for CERN needs. The MTA section has started with a proactive approach sharing its tools and experience with the CERN LabVIEW community. Its framework (RADE) for CERN integrated application development has been made available to the users. Courses on RADE have been integrated into the standard National Instruments training program at CERN. RADE and LabVIEW support were merged together in 2010 on a single email address:labview.support@cern.ch For more information please...

  5. Online labs and the MARVEL experience

    Directory of Open Access Journals (Sweden)

    Dieter Mueller

    2005-06-01

    Full Text Available MARVEL is a Leonardo da Vinci project that provides a framework to analyse the pedagogic effectiveness of online labs in various heterogeneous areas that include solar energy, robotics, electronics and electro-pneumatics. It is also used as a test bench to compare the implementation of purely remote labs, where all devices are real, versus mixed-reality environments, where real devices work together with simulation models. This paper describes the basic concepts underlying the implementation of such online labs and presents two case studies (which are openly available to the public. A final section discusses the main pedagogical implications of online labs and presents the research directions that are being considered as a follow-up from this project.

  6. The Udall Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Udall lab is interested in genome evolution and cotton genomics.The cotton genus ( Gossypium) is an extraordinarily diverse group with approximately 50 species...

  7. LIDAR Research & Development Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The LIDAR Research and Development labs are used to investigate and improve LIDAR components such as laser sources, optical signal detectors and optical filters. The...

  8. Clothing Systems Design Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Clothing Systems Design Lab houses facilities for the design and rapid prototyping of military protective apparel.Other focuses include: creation of patterns and...

  9. Secure Processing Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Secure Processing Lab is the center of excellence for new and novel processing techniques for the formation, calibration and analysis of radar. In addition, this...

  10. Guidelines for Urban Labs

    DEFF Research Database (Denmark)

    Scholl, Christian; Agger Eriksen, Mette; Baerten, Nik

    2017-01-01

    These guidelines are intended for team members and managers of urban labs and, more generally, for civil servants and facilitators in cities working with experimental processes to tackle complex challenges. They aim to support the everyday practice of collaboratively experimenting and learning ho...... the result is inspiring and instructive for all those who want to wrap their minds around experimental co-creative approaches to urban governance and city development.......These guidelines are intended for team members and managers of urban labs and, more generally, for civil servants and facilitators in cities working with experimental processes to tackle complex challenges. They aim to support the everyday practice of collaboratively experimenting and learning how...... to create more sustainable and inclusive cities. Policy-makers and urban development stakeholders may struggle to implement urban labs, and seek guidance for further development. Evidence-based guidelines and design principles are needed to decide for which types of challeng- es urban labs are most suited...

  11. Laser Research Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Laser Research lab is thecenter for the development of new laser sources, nonlinear optical materials, frequency conversion processes and laser-based sensors for...

  12. Next Practise Labs

    DEFF Research Database (Denmark)

    2016-01-01

    Klaus Thestrup explains what Next Practise Labs are and how that involves both participants, the researcher and teachers. He also talks about how the term builds upon the open laboratory and experimenting communities - and cultures of creativity.......Klaus Thestrup explains what Next Practise Labs are and how that involves both participants, the researcher and teachers. He also talks about how the term builds upon the open laboratory and experimenting communities - and cultures of creativity....

  13. Microbewerking met behulp van lasers

    NARCIS (Netherlands)

    Ezendam, M.M.M.

    1994-01-01

    Het bewerken van materialen met behulp van lasers staat momenteel enorm in de belangstelling, en terecht. De ontwikkeling van bestaande en nieuwe typen lasers staat alles behalve stil. Ontwikkelingen bevinden zich met name in het gebied van hogere vermogens, betere bundelkwaliteit en hogere

  14. Gezondheidsrisico's in verband met het werken met Polychloorbifenylen : een onderzoek

    NARCIS (Netherlands)

    Geuskens, R.B.M.; Nossent, S.M.; Koëter, H.B.W.M.; Dreef-van der Meulen, H.C.; Stijkel, A.; Zielhuis, R.L.

    1989-01-01

    Met behulp van gegevens verkregen uit een werkplekinventarisatie naar gegevens over produktie/gebruik, risicopopulatie en (mogelijke) blootstelling aan polychloorbifenylen (PCB's), en een literatuurstudie naar mogelijke schadelijke eigenschappen van PCB's op het reproductiesysteem en/of nageslacht

  15. Lab Attendance and Academic Performance

    OpenAIRE

    Adair, Kirk; Swinton, Omari H.

    2012-01-01

    The benefits from attendance of lectures have been established in the literature. This paper focuses on attendance not of the lecture, but of smaller labs. These labs are 50 minutes one-day-a-week sessions to emphasis material covered during lecture. Using a 200-student Principles of Economics class that covers microeconomics with six different labs, we investigate the effect of lab attendance on exam performance by taking into account individual characteristics. We find that lab attendance b...

  16. Compost voor biggen met diarree

    NARCIS (Netherlands)

    Gommers, T.

    1990-01-01

    Het geven van compost aan biggen met diarree zorgt op het Proefstation voor de Varkenshouderij voor minder medicijngebruik. De biggen krijgen de compost van groente-, fruit- en tuinafval vanaf de tweede dag na de geboorte, zodra de diarreeverschijnselen zichtbaar zijn.

  17. Bewaring aardappelen met koeling & ventileren

    NARCIS (Netherlands)

    Kamp, J.A.L.M.; Montsma, M.P.

    2013-01-01

    In de praktijk blijkt dat nogal wat telers de bewaring ondersteunen met koelapparatuur. Dit betreft vooral pootaardappelen (verlenging kiemrust), de lange bewaring van tafelaardappelen en fritesaardappelen. Dit resulteert in een hoger energieverbruik, maar wel in een betere kwaliteit bij aflevering.

  18. The NOAO Data Lab

    Science.gov (United States)

    Fitzpatrick, M.; Olsen, K.; Stobie, E. B.; Mighell, K. J.; Norris, P.

    2015-09-01

    We describe the NOAO Data Lab to help community users take advantage of current large surveys and prepare them even larger surveys in the era of LSST. The Data Lab will allow users to efficiently utilize catalogs of billions of objects, combine traditional telescope image and spectral data with external archives, share custom results with collaborators, publish data products to other users, and experiment with analysis toolkits. Specific science cases will be used to develop a prototype framework and tools, allowing us to work directly with scientists from survey teams to ensure development remains focused on scientifically productive tasks.

  19. SenseLab

    Science.gov (United States)

    Crasto, Chiquito J.; Marenco, Luis N.; Liu, Nian; Morse, Thomas M.; Cheung, Kei-Hoi; Lai, Peter C.; Bahl, Gautam; Masiar, Peter; Lam, Hugo Y.K.; Lim, Ernest; Chen, Huajin; Nadkarni, Prakash; Migliore, Michele; Miller, Perry L.; Shepherd, Gordon M.

    2009-01-01

    This article presents the latest developments in neuroscience information dissemination through the SenseLab suite of databases: NeuronDB, CellPropDB, ORDB, OdorDB, OdorMapDB, ModelDB and BrainPharm. These databases include information related to: (i) neuronal membrane properties and neuronal models, and (ii) genetics, genomics, proteomics and imaging studies of the olfactory system. We describe here: the new features for each database, the evolution of SenseLab’s unifying database architecture and instances of SenseLab database interoperation with other neuroscience online resources. PMID:17510162

  20. CDC Lab Values

    Centers for Disease Control (CDC) Podcasts

    2015-02-02

    More than fifteen hundred scientists fill the lab benches at CDC, logging more than four million hours each year. CDC’s laboratories play a critical role in the agency’s ability to find, stop, and prevent disease outbreaks. This podcast provides a brief overview of what goes on inside CDC’s labs, and why this work makes a difference in American’s health.  Created: 2/2/2015 by Office of the Associate Director for Communication (OADC).   Date Released: 2/2/2015.

  1. The Crime Lab Project.

    Science.gov (United States)

    Hein, Annamae J.

    2003-01-01

    Describes the Crime Lab Project, which takes an economical, hands-on, interdisciplinary approach to studying the career of forensics in the middle or high school classroom. Includes step-by-step student requirements for the investigative procedure, a sample evidence request form, and an assessment rubric. (KHR)

  2. Physics lab in spin

    CERN Multimedia

    Hawkes, N

    1999-01-01

    RAL is fostering commerical exploitation of its research and facilities in two main ways : spin-out companies exploit work done at the lab, spin-in companies work on site taking advantage of the facilities and the expertise available (1/2 page).

  3. A Big Bang Lab

    Science.gov (United States)

    Scheider, Walter

    2005-01-01

    The February 2005 issue of The Science Teacher (TST) reminded everyone that by learning how scientists study stars, students gain an understanding of how science measures things that can not be set up in lab, either because they are too big, too far away, or happened in a very distant past. The authors of "How Far are the Stars?" show how the…

  4. Lab on paper

    NARCIS (Netherlands)

    Zhao, Weian; van den Berg, Albert

    2008-01-01

    Lab-on-a-chip (LOC) devices, which are suited to portable point-of-care (POC) diagnostics and on-site detection, hold great promise for improving global health, and other applications.1–8 While their importance and utility are widely acknowledged and extensive research has been conducted in the

  5. Een model met een smaakje (Interview met Caroline Labrie)

    NARCIS (Netherlands)

    Langen, E.; Labrie, C.W.

    2013-01-01

    Over smaak valt niet te twisten. En toch gebeurt dat maar al te vaak. "Er kan oeverloos over de smaak van paprika's worden gepraat en gediscussieerd. Daarom is het belangrijk dat de smaak van paprika's geobjectiveerd wordt", vertelt Caroline Labrie van Wageningen UR Glastuinbouw. Dat kan met een

  6. Mesure de la section efficace de production de paires de quarks top dans le canal lepton+tau+jets+MET dans l'experience D0 et interpretation en termes de boson de Higgs charge

    Energy Technology Data Exchange (ETDEWEB)

    Lacroix, Florent [Clermont-Ferrand U.

    2008-12-01

    The standard model of particle physics describes the matter as elementary particles interacting via strong and electroweak interactions. The top quark is the heaviest quark described by this model and has been discovered in 1995 by CDF and D collaborations in proton-antiproton collisions at the Tevatron. This thesis is devoted to the measurement of the top pair production cross-section via the strong interaction, in a final state composed of one lepton, one hadronic tau, two b-jets and missing transverse energy. This analysis uses the 1,2 fb

  7. Digital Social Science Lab

    DEFF Research Database (Denmark)

    Svendsen, Michael; Lauersen, Christian Ulrich

    2015-01-01

    at the Faculty of Social Sciences. DSSL will host and facilitate an 80 m2 large mobile and intelligent study- and learning environment with a focus on academic events, teaching and collaboration. Besides the physical settings DSSL has two primary functions: 1. To implement relevant social scientific software......At the Faculty Library of Social Sciences (part of Copenhagen University Library) we are currently working intensely towards the establishment of a Digital Social Science Lab (DSSL). The purpose of the lab is to connect research, education and learning processes with the use of digital tools...... and hardware at the disposal for students and staff at The Faculty of Social Sciences along with instruction and teaching in the different types of software, e.g. Stata, Nvivo, Atlas.ti, R Studio, Zotero and GIS-software. 2. To facilitate academic events focusing on use of digital tools and analytic software...

  8. Nordic Study Labs

    DEFF Research Database (Denmark)

    Jørnø, Rasmus Leth Vergmann; Hestbech, Astrid Margrethe; Gynther, Karsten

    2016-01-01

    Denne rapport dokumenterer projektet Nordplus projektet The Nordic Study Lab. Projektet har haft til formål at udveksle eksisterende viden blandt projektdeltagerne om etablering og drift af distribueret uddannelse med særlig fokus på læringscentre. I løbet af en serie af studiebesøg har partnere...... med at skabe kvalificeret uddannelse på distancen. Nordic Study Labs projektet har afsløret et rigt reservoir af eksisterende erfaringer, med et stort transferpotentiale og både unikke og eksemplariske løsninger på uddannelses­ problematikker. Mange af de nordiske lande har mange års succesrige...

  9. Mogelijkheden voor notenteelt met tussengewas

    NARCIS (Netherlands)

    Oosterbaan, A.; Schepers, H.

    2005-01-01

    Er zijn enkele presentaties gehouden over de ervaringen met de teelt van walnoten in Nederland tijdens het vijfde Internationale Walnotencongres in Sorrento, Italië, gehouden in november 2004. De productie van walnoten in Nederland stelt nog niet veel voor. Er is dus ruimte voor eigen productie

  10. Allemaal andersdenkenden: omgaan met cultuurverschillen

    NARCIS (Netherlands)

    Hofstede, G.; Hofstede, G.J.; Minkov, M.

    2011-01-01

    Mensen uit andere landen denken, voelen en handelen anders dan wij hier gewend zijn. Ook landgenoten uit een andere streek of een andere sociale klasse gedragen zich vaak anders dan wij. In een open samenleving komt iedereen vaker met zulke andersdenkenden in aanraking dan vroeger. Voor die anderen

  11. Water zuiveren met drijvende planten

    NARCIS (Netherlands)

    Keizer-Vlek, H.E.; Verdonschot, P.F.M.; Verdonschot, R.C.M.; Dekkers, T.B.M.

    2013-01-01

    Drijvende moerassystemen met helofyten, ook wel floating treatment wetlands of floatlands genoemd, worden in Nederland uitsluitend toegepast om natuurbeleving te stimuleren en de biodiversiteit van het oppervlaktewater te vergroten. Floatlands zijn echter mogelijk ook geschikt om nutriënten uit het

  12. Voedingsnavorsing met die weidende dier

    African Journals Online (AJOL)

    van veral beeste (Bisschop, 1964; Niemann, Lombard & Van. Schalkwyk, 1963). In teenstelling met die relatiewe groot hoeveelheid inligting oor die chemiese samestelling van natuurlike weidings, is daar betreklik min bekend oor die verteerbaarheid en vrywillige in- name daarvan deur herkouers. 'n Skerp daling in die ...

  13. Steeds preciezer met de sensor

    NARCIS (Netherlands)

    Houweling, van P.; PPO Akkerbouw, Groene Ruimte en Vollegrondsgroente

    2014-01-01

    Maurits Bax uit Luyksgestel werkt met de Yara N-sensor. Zo spuit hij minder dan een derde van de voorgeschreven dosering voor loofdodingsmiddel in aardappelen. Andere toepassingen zijn minder praktijkrijp, zoals aardappelen bijmesten. Daarvoor lijkt een app, ontwikkeld door het PPO, uitkomst te gaan

  14. Archimedes Remote Lab for Secondary Schools

    NARCIS (Netherlands)

    Garcia Zubia, J.; Angulo Martinez, I.; Martinez Pieper, G.; Lopez de Ipina Gonzalez de Artaza, D.; Hernandez Jayo, U.; Orduna Fernandez, P.; Dziabenko, O.; Rodriguez Gil, L.; van Riesen, Siswa; Anjewierden, Anjo Allert; Kamp, Ellen; de Jong, Anthonius J.M.

    2015-01-01

    This paper presents a remote lab designed for teaching the Archimedes’ principle to secondary school students, as well as an online virtual lab on the general domain of buoyancy. The Archimedes remote lab is integrated into WebLab-Deusto. Both labs are promoted for usage in frame of the Go-Lab

  15. La metáfora

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2007-01-01

    cuestionamiento de la lógica y de las leyes establecidas se corresponde con lo que denominamos autonomía. Así pues, el proceso de autonomía zapatista consiste, por un lado, en la declaración y aplicación de los derechos indígenas y, por otro, en la creación de un sentido alternativo, donde la metáfora juega un...

  16. ONDERHOUD MET EDWIN ARRISON1

    African Journals Online (AJOL)

    Toe gaan ek met 'n UDF t‑hemp kerk toe. En die UDF t‑hemp was baie geel so mense kon dit maklik en duidelik sien, en agterop het gestaan “UDF unites; apartheid divides.” En daar was mense wat gevoel het dat ons politiek in die kerk wou inbring. – veral die persone wat in die leierskap was. Nie die predikant soveel nie,.

  17. DESY NanoLab

    Directory of Open Access Journals (Sweden)

    Andreas Stierle

    2016-06-01

    Full Text Available The DESY NanoLab is a facility providing access to nano-characterization, nano-structuring and nano-synthesis techniques which are complementary to the advanced X-ray techniques available at DESY’s light sources. It comprises state-of-the art scanning probe microscopy and focused ion beam manufacturing, as well as surface sensitive spectroscopy techniques for chemical analysis. Specialized laboratory x-ray diffraction setups are available for a successful sample pre-characterization before the precious synchrotron beamtimes. Future upgrades will include as well characterization of magnetic properties.

  18. e-Learning - Physics Labs

    Science.gov (United States)

    Mohottala, Hashini

    2014-03-01

    The general student population enrolled in any college level class is highly diverse. An increasing number of ``nontraditional'' students return to college and most of these students follow distance learning degree programs while engaging in their other commitments, work and family. However, those students tend to avoid taking science courses with labs, mostly because of the incapability of remotely completing the lab components in such courses. In order to address this issue, we have come across a method where introductory level physics labs can be taught remotely. In this process a lab kit with the critical lab components that can be easily accessible are conveniently packed into a box and distributed among students at the beginning of the semester. Once the students are given the apparatus they perform the experiments at home and gather data All communications with reference to the lab was done through an interactive user-friendly webpage - Wikispaces (WikiS). Students who create pages on WikiS can submit their lab write-ups, embed videos of the experiments they perform, post pictures and direct questions to the lab instructor. The students who are enrolled in the same lab can interact with each other through WikiS to discuss labs and even get assistance.

  19. Urban Living Labs: A living lab way of working

    OpenAIRE

    van Bueren, E.M.

    2017-01-01

    Urban living labs have become a popular phenomenon in today’s cities. The Living Lab approach would provide real life research with its multiple stakeholders in a co-innovating inclusive setting, crucial in creating metropolitan solutions with impact, that will be adopted smoothly and swiftly by all involved, and thus help achieve prosperous living environments that are more liveable, sustainable, resilient and just. With these ambitions, urban living labs are important links in the achieveme...

  20. 5 Pre-Lab and Lab Activities for Newtonian Mechanics

    Science.gov (United States)

    Mangold, James

    2010-03-01

    Key to success of a lab activity is the student's prerequisite skills. This workshop focuses on 5 pre-lab white board activities with the corresponding lab activities in Newtonian mechanics utilizing the GMLAD. The activities will cover projectile motion; kinematics, Newton's 2nd Law, Determination of Friction and its Coefficient, Conservation of Energy, Determination of the Spring Constant, and Conservation of Momentum in 2 Dimensions. Limited to 24 participants - 2 hours - Cost 5.00

  1. Tritium at Jefferson Lab

    Science.gov (United States)

    Bane, Jason; Jefferson Lab Hall A Collaboration Collaboration

    2017-09-01

    Jefferson Lab's recently upgraded accelerator will provide the perfect opportunity to increase the quality and quantity of the electron scattering world data on tritium. Tritium, the radioactive isotope of hydrogen with a half-life of 12 years, was last used in a large scale electron scattering experiment a few decades ago. This Fall Jefferson Lab will play host to a set of very exciting electron scattering experiments involving tritium. A 25 cm aluminum cell will be filled with 1 kCi of tritium with an internal pressure of approximately 200 psi at 295 kelvin. The tritium target will first see a 10.6 GeV beam to probe the deep inelastic scattering region to study the down to up quark ratio and the EMC effect. Then the beam will be set to 4.3 GeV to investigate SRCs and momentum distributions in the quasi-elastic scattering regime. If time permits, elastic scattering will be used to extract the ratio of the charge radius of tritium and helium3.

  2. 76 FR 401 - MetLife Insurance Company of Connecticut, et al.

    Science.gov (United States)

    2011-01-04

    ... Funds' adviser, profit distributions from the adviser. These profits from investment advisory fees may...''). ACTION: Notice of application for an order pursuant to Section 26(c) of the Investment Company Act of... CPPVUL 1''), MetLife Investors Insurance Company (``MetLife Investors''), MetLife Investors Variable...

  3. Urban Living Labs : A living lab way of working

    NARCIS (Netherlands)

    van Bueren, E.M.

    2017-01-01

    Urban living labs have become a popular phenomenon in today’s cities. The Living Lab approach would provide real life research with its multiple stakeholders in a co-innovating inclusive setting, crucial in creating metropolitan solutions with impact, that will be adopted smoothly and swiftly by all

  4. The Jefferson Lab Program

    International Nuclear Information System (INIS)

    The kW-class infrared (IR) free electron laser (FEL) at the Thomas Jefferson National Accelerator Facility (Jefferson Lab) had the capability of producing intra-cavity Thomson scattering of the IR off the electron beam thus producing high average flux, sub-picosecond x-rays. We have measured these x-rays and demonstrated the energy tunability range from 3.5 keV to 18 keV. The corresponding flux and brightness have been estimated and will be discussed. In 2002, the FEL was disassembled and has been reconfigured to produce 10 kW average power IR. We present the estimated x-ray capabilities for the new FEL and discuss potential applications

  5. The lab of fame

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    For a third time, CERN is organising the Swiss heat of Famelab, the world’s leading science communication competition that has already gathered over 5,000 young and talented scientists and engineers from all across the planet.   Besides their degrees, the scientists who participate in Famelab have another thing in common: their passion for communicating science. Coming from a variety of scientific fields, from medicine to particle physics and microbiology, the contestants have three minutes to present a science, technology, mathematics or engineering-based talk using only the props he or she can carry onto the stage; PowerPoint presentations are not permitted. The contestants are then judged by a panel of three judges who evaluate the content, clarity and charisma of their talks. What's unique about FameLab is the fact that content is an important aspect of the performance. At the end of their presentation, contestants are often questioned about the scientific relevance of...

  6. GitLab repository management

    CERN Document Server

    Hethey, Jonathan

    2013-01-01

    A simple, easy to understand tutorial guide on how to build teams and efficiently use version control, using GitLab.If you are a system administrator in a company that writes software or are in charge of an infrastructure, this book will show you the most important features of GitLab, including how to speed up the overall process

  7. Acuut nierfalen door vergiftiging met gordijnzwam

    NARCIS (Netherlands)

    Bouhbouh, S.; Haverkamp, L.; Kuyper, T.W.; Wolff, F.A.; Barendregt, J.N.M.

    2011-01-01

    Achtergrond Inname van bepaalde soorten gordijnzwammen kan leiden tot nierfalen. In Nederland is deze paddenstoelvergiftiging niet eerder beschreven. Casus Een 58-jarige vrouw presenteerde zich met hoofdpijn, braken en afnemende urineproductie, voorafgegaan door enkele dagen met pijnlijke,

  8. Roze appelluis bestrijden met plantenolie en feromoon

    NARCIS (Netherlands)

    Tol, van R.W.H.M.; Helsen, H.H.M.

    2004-01-01

    Gegevens figuren: 1) Reactie van gevleugelde roze appelluis op een onbespoten appelblad en op een met plantenoliën behandeld appelblad; 2) Reactie van gevleugelde roze appelluis op onbespoten appeltakken en op met Denka behandelde appeltakken

  9. Thinking Outside the Lab

    Science.gov (United States)

    Colter, Tabitha

    2017-01-01

    As an undergraduate physics major who spent 2015 deep in a quantum optics lab at Oak Ridge National Laboratory, I knew my 2016 experience with the House of Representatives Energy and Commerce Committee would be a completely new challenge. I have long had a passion for the bridge of communication between the technical and non-technical worlds but it was only through my AIP Mather internship this summer that I was able to see that passion come to life in the realm of science policy. Suddenly, I went from squeezing political philosophy classes into my packed schedule to witnessing the political process first-hand. I was thrilled to find that the skills of critical thinking and communicating complex issues I have developed throughout my training as a physicist were directly applicable to my work in Congress. Overall, my experience this summer has given me insight into the inner workings of the federal policy process, deepened my appreciation for the work of government employees to keep Congressional members informed on the pressing current issues, and exposed me to a whole range of alternative careers within science. AIP and SPS

  10. Advanced Active Acoustics Lab (AAAL)

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Active Acoustics Lab (AAAL) is a state-of-the-art Undersea Warfare (USW) acoustic data analysis facility capable of both active and passive underwater...

  11. An Annotated Math Lab Inventory.

    Science.gov (United States)

    Schussheim, Joan Yares

    1980-01-01

    A listing of mathematics laboratory material is organized as follows: learning kits, tape programs, manipulative learning materials, publications, math games, math lab library, and an alphabetized listing of publishers and/or companies offering materials. (MP)

  12. Pollution hazard closes neutrino lab

    CERN Multimedia

    Jones, Nicola

    2003-01-01

    "A leading astrophysics laboratory in Italy has closed down all but one of its experiments over concerns that toxic polluants could leak form the underground lab into the local water supply" (0.5 page)

  13. Common Systems Integration Lab (CSIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The Common Systems Integration Lab (CSIL)supports the PMA-209 Air Combat Electronics Program Office. CSIL also supports development, test, integration and life cycle...

  14. Virtual Labs and Virtual Worlds

    Science.gov (United States)

    Boehler, Ted

    2006-12-01

    Virtual Labs and Virtual Worlds Coastline Community College has under development several virtual lab simulations and activities that range from biology, to language labs, to virtual discussion environments. Imagine a virtual world that students enter online, by logging onto their computer from home or anywhere they have web access. Upon entering this world they select a personalized identity represented by a digitized character (avatar) that can freely move about, interact with the environment, and communicate with other characters. In these virtual worlds, buildings, gathering places, conference rooms, labs, science rooms, and a variety of other “real world” elements are evident. When characters move about and encounter other people (players) they may freely communicate. They can examine things, manipulate objects, read signs, watch video clips, hear sounds, and jump to other locations. Goals of critical thinking, social interaction, peer collaboration, group support, and enhanced learning can be achieved in surprising new ways with this innovative approach to peer-to-peer communication in a virtual discussion world. In this presentation, short demos will be given of several online learning environments including a virtual biology lab, a marine science module, a Spanish lab, and a virtual discussion world. Coastline College has been a leader in the development of distance learning and media-based education for nearly 30 years and currently offers courses through PDA, Internet, DVD, CD-ROM, TV, and Videoconferencing technologies. Its distance learning program serves over 20,000 students every year. sponsor Jerry Meisner

  15. Differences in MetS marker prevalence between black African and ...

    African Journals Online (AJOL)

    Multiple linear regression analysis, independent of covariates, showed that the albumin:creatinine ratio is explained only by glucose in Africans. Conclusion: African women, as a group, present with few MetS risk factors, and glucose is associated with renal function risk in Africans. Keywords: MetS, metabolic syndrome, ...

  16. CompTIA Network+ Lab Manual

    CERN Document Server

    Skandier, Toby

    2012-01-01

    Gain street-smart skills in network administration Think of the most common and challenging tasks that network administrators face, then read this book and find out how to perform those tasks, step by step. CompTIA Network + Lab Manual provides an inside look into the field of network administration as though you were actually on the job. You'll find a variety of scenarios and potential roadblocks, as well as clearly mapped sections to help you prepare for the CompTIA Network+ Exam N10-005. Learn how to design, implement, configure, maintain, secure, and troubleshoot a network with this street

  17. Quark Hadron Duality - Recent Jefferson Lab Results

    Energy Technology Data Exchange (ETDEWEB)

    Niculescu, Maria Ioana [James Madison Univ., Harrisonburg, VA (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-08-01

    The duality between the partonic and hadronic descriptions of electron--nucleon scattering is a remarkable feature of nuclear interactions. When averaged over appropriate energy intervals the cross section at low energy which is dominated by nucleon resonances resembles the smooth behavior expected from perturbative QCD. Recent Jefferson Lab results indicate that quark-hadron duality is present in a variety of observables, not just the proton F2 structure function. An overview of recent results, especially local quark-hadron duality on the neutron, are presented here.

  18. Differential elastic and inelastic cross sections in 1. 5 <= E/sub 0/ <= 25 keV He/sup +/-H collisions at scattering angles thetasub(lab) ranging from 5' to 2/sup 0/

    Energy Technology Data Exchange (ETDEWEB)

    Bordenave-Montesquieu, D.; Nouet, P.; Boutonnet, A.; Bergnes, C.; Dagnac, R.

    1987-09-14

    Elastic and inelastic cross sections, differential in energy loss and scattering angle, have been determined from the energy loss spectra of 1.5 - 25 keV He/sup +/ scattered from atomic hydrogen at scattering angles from 5'-2/sup 0/ (laboratory frame). The experimental results compare favourably with the experimental and theoretical data obtained at low incident energies by other authors, but for the higher energies, the present results exhibit a strong disagreement with many of the reported calculations.

  19. Virtual Compton scattering off the proton at Jefferson Lab (experiment E93050): preliminary results of the cross-sections of the reaction (ep{yields}ep{gamma}) in order to find out the generalized polarizabilities (GPs) of the proton at Q{sup 2} = 1.9 GeV{sup 2}; Diffusion compton virtuelle a jefferson lab (experience E93050): resultat preliminaire des sections efficaces (ep{yields}ep{gamma}) en vue d'extraire les polarisabilites generalisees du proton a Q{sup 2} = 1.9 GEV{sup 2}

    Energy Technology Data Exchange (ETDEWEB)

    Jaminion, St

    2000-12-01

    Virtual Compton Scattering off the proton ({gamma}{sup *}p {yields} {gamma}p) at low energy is accessible via the reaction (ep {yields} ep{gamma}), and contains 6 new observables: Generalized Polarizabilities (GPs). Their extraction needs the measurement of absolute five fold differential cross sections for photon electroproduction off the proton. The determination of GPs will put new constraints on models of nucleon structure in the non-perturbative Quantum Chromodynamics region. Following the Mainz experiment realized at four momentum transfer Q{sup 2} = 0.33 GeV{sup 2}, the E93050 experiment which was performed in the Hall A of Jefferson Lab during march-april 1998, will allow the measurement of combinations of generalized polarizabilities at Q{sup 2}=1 and 1.9 GeV{sup 2}. The final electron and proton were detected in coincidence in the Hall A high resolution spectrometers. The final photon is reconstructed like a missing particle, and all its variables can be determined. We had to optimize optics tensor of each spectrometer in order to have the best reconstruction at vertex point. We created an acceptance function, which is included in the software simulating solid angle. We determined different cuts to substract our background dominating (ep {yields} ep{gamma}) reaction. This work allows to carry out our first photon electro-production cross section measurement at Q{sup 2}=1.9 GeV{sup 2}. The results seem to indicate a measurable effect of generalized polarizabilities, which remains however to be confirmed. (author)

  20. Status of chemistry lab safety in Nepal

    Science.gov (United States)

    Kandel, Krishna Prasad; Neupane, Bhanu Bhakta

    2017-01-01

    Chemistry labs can become a dangerous environment for students as the lab exercises involve hazardous chemicals, glassware, and equipment. Approximately one hundred thousand students take chemistry laboratory classes annually in Nepal. We conducted a survey on chemical lab safety issues across Nepal. In this paper, we assess the safety policy and equipment, protocols and procedures followed, and waste disposal in chemistry teaching labs. Significant population of the respondents believed that there is no monitoring of the lab safety in their lab (p<0.001). Even though many labs do not allow food and beverages inside lab and have first aid kits, they lack some basic safety equipment. There is no institutional mechanism to dispose lab waste and chemical waste is disposed haphazardly. Majority of the respondents believed that the safety training should be a part of educational training (p = 0.001) and they would benefit from short course and/or workshop on lab safety (p<0.001). PMID:28644869

  1. Jefferson Lab E89-044 experiment: study of the quasi-elastic He{sup 3}(e,e'p)d reaction in parallel kinematics; Experience E89-044 de diffusion quasi-elastique {sup 3}He(e,e'p) au Jefferson Laboratory: analyse des sections efficaces de desintegration a deux corps en cinematique parallele

    Energy Technology Data Exchange (ETDEWEB)

    Penel-Nottaris, E

    2004-07-01

    The Jefferson Lab Hall A E89-044 experiment has measured the He{sup 3}(e,e'p) reaction cross-sections. The extraction of the longitudinal and transverse response functions for the two-body break-up He{sup 3}(e,e'p)d reaction in parallel kinematics allows the study of the bound proton electromagnetic properties inside the He{sup 3} nucleus and the involved nuclear mechanisms beyond plane waves approximations, for missing momenta of 0 and +- 300 MeV/c and transferred momenta from 0.8 to 4.1 GeV{sup 2}. Preliminary cross-sections have been obtained after calibration of the experimental setup by fitting theoretical models averaged over the experimental phase-space using a Monte-Carlo simulation. The 8% systematic error on cross-sections is linked mainly to the absolute normalization of the target density: the elastic scattering data analysis will allow to reduce this error. The preliminary results show some disagreement with theoretical predictions for the forward angles kinematics around 0 MeV/c missing momenta and sensitivity to final state interactions and He{sup 3} waves functions for missing momenta of 300 MeV/c. The longitudinal and transverse separation should constraint theoretical models more strongly. (author)

  2. Advanced Physics Lab at TCU

    Science.gov (United States)

    Quarles, C. A.

    2009-04-01

    The one semester, one credit hour Modern Physics Lab is viewed as a transition between the structured Physics 1 and 2 labs and junior/senior research. The labs focus on a variety of experiments built around a multichannel analyzer, various alpha, beta and gamma ray detectors and weak radioactive sources. Experiments include radiation safety and detection with a Geiger counter and NaI detector, gamma ray spectroscopy with a germanium detector, beta spectrum, alpha energy loss, gamma ray absorption, Compton effect, nuclear and positron annihilation lifetime, speed of gamma rays. Other experiments include using the analog oscilloscope, x-ray diffraction of diamond and using an SEM/EDX. Error analysis is emphasized throughout. The semester ends with an individual project, often an extension of one of the earlier experiments, and students present their results as a paper and an APS style presentation to the department.

  3. Is neurofeedback effectief bij kinderen met ADHD?

    NARCIS (Netherlands)

    de Hen, M.H.; Geurts, H.M.

    2008-01-01

    Kan neurofeedback verantwoord ingezet worden bij de behandeling van kinderen met ADHD? Omdeze vraag te beantwoorden worden zeven recente onderzoeken naar de effectiviteit van neurofeedback bij kinderen met ADHD geanalyseerd. Ondanks dat de resultaten in eerste instantie lijken te suggereren dat

  4. Resensies: Vakansiehuis met swembad | Maas | Tydskrif vir ...

    African Journals Online (AJOL)

    Resensies: Vakansiehuis met swembad. Tycho Maas. Abstract. Book Title: Vakansiehuis met swembad. Book Author: Herman Koch. Vertaal deur Daniel Hugo. Pretoria: Protea Boekhuis, 2015. 288 pp. ISBN: 978-1-4853-0545-3. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT ...

  5. Lab-on-fiber technology

    CERN Document Server

    Cusano, Andrea; Crescitelli, Alessio; Ricciardi, Armando

    2014-01-01

    This book focuses on a research field that is rapidly emerging as one of the most promising ones for the global optics and photonics community: the "lab-on-fiber" technology. Inspired by the well-established 'lab on-a-chip' concept, this new technology essentially envisages novel and highly functionalized devices completely integrated into a single optical fiber for both communication and sensing applications.Based on the R&D experience of some of the world's leading authorities in the fields of optics, photonics, nanotechnology, and material science, this book provides a broad and accurate de

  6. The reliability of the National Cholesterol Education Program's Adult Treatment Panel III (NCEP/ATP III) and the International Diabetes Federation (IDF) definitions in diagnosing metabolic syndrome (MetS) among Gaza Strip Palestinians.

    Science.gov (United States)

    Sirdah, Mahmoud M; Abu Ghali, Asmaa S; Al Laham, Nahed A

    2012-01-01

    Metabolic syndrome (MetS) which is a multifaceted syndrome, has been demonstrated as a common precursor for developing cardiovascular diseases and/or type 2 diabetes mellitus. Different diagnostic definitions for MetS have been proposed and recommended. We set up to evaluate the reliabilities of the National Cholesterol Education Program's Adult Treatment Panel III (NCEP/ATP III) and the International Diabetes Federation (IDF) definitions in diagnosing MetS among Gaza Strip Palestinians. This cross sectional study involved a randomly selected two hundred and thirty apparently healthy adults from the Gaza Strip. Anthropometric measurements, blood pressure, fasting plasma glucose, lipid profile, and questionnaire interviews were performed. The overall prevalence of MetS in our Gaza Strip cohort was 23.0% and 39.5% according to NCEP/ATP III and IDF definitions respectively (pdefinition (mean 3.42 ± 0.63 vs 3.52 ± 0.69 respectively, p=0.865). Both IDF and NCEP/ATP III showed an increased prevalence of MetS with age, and body mass index (BMI), however they revealed different prevalence trends with sex. Except for BMI, there were no significant differences in the general and metabolic related characteristics between subjects with MetS of IDF and NCEP/ATP III definitions. Independently of the definition used, MetS is highly prevalent in Gaza Strip population, with a steady increase in MetS prevalence through age and BMI. The IDF definition tends to give higher values for MetS prevalence, and therefore could be more appropriate for diagnosing MetS in Gaza Strip cohort. Copyright © 2012 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  7. Exclusive processes at Jefferson Lab

    Indian Academy of Sciences (India)

    Exclusive processes such as proton–proton elastic scattering, meson photoproduction, and deuteron photodisintegration have been pursued extensively at many laboratories over the years in the search for such a transition, particularly at Jefferson Lab in recent years, taking the advantage of the high luminosity capability of ...

  8. A Simple, Successful Capacitor Lab

    Science.gov (United States)

    Ennis, William

    2011-01-01

    Capacitors are a fundamental component of modern electronics. They appear in myriad devices and in an enormous range of sizes. Although our students are taught the function and analysis of capacitors, few have the opportunity to use them in our labs.

  9. 75 FR 16205 - MetLife Insurance Company of Connecticut, et al.

    Science.gov (United States)

    2010-03-31

    ... Funds' adviser, profit distributions from the adviser. These profits from investment advisory fees may...''). ACTION: Notice of application for an order pursuant to Section 26(c) of the Investment Company Act of...''), MetLife of CT Fund UL for Variable Life Insurance (``Fund UL''), MetLife Investors Insurance Company...

  10. CoMET: A Mesquite package for comparing models of continuous character evolution on phylogenies

    Directory of Open Access Journals (Sweden)

    Chunghau Lee

    2006-01-01

    Full Text Available Continuously varying traits such as body size or gene expression level evolve during the history of species or gene lineages. To test hypotheses about the evolution of such traits, the maximum likelihood (ML method is often used. Here we introduce CoMET (Continuous-character Model Evaluation and Testing, which is module for Mesquite that automates likelihood computations for nine different models of trait evolution. Due to its few restrictions on input data, CoMET is applicable to testing a wide range of character evolution hypotheses. The CoMET homepage, which links to freely available software and more detailed usage instructions, is located at http://www.lifesci.ucsb.edu/eemb/labs/oakley/software/comet.htm.

  11. Met1-linked Ubiquitination in Immune Signalling

    DEFF Research Database (Denmark)

    Fiil, Berthe Katrine; Gyrd-Hansen, Mads

    2014-01-01

    identification of physiological substrates for Met1-Ub in response to activation of innate immune receptors. These discoveries have significantly advanced our understanding of how non-degradative ubiquitin modifications control pro-inflammatory responses mediated by nuclear factor κB and mitogen......Methionine 1-linked ubiquitin chains (Met1-Ub), or linear ubiquitin, has emerged as a central post-translational modification in innate immune signalling. Molecular machinery that assembles, senses and, more recently, disassembles Met1-Ub has been identified, and technical advances have enabled...

  12. Mars MetNet Mission Payload Overview

    Science.gov (United States)

    Harri, A.-M.; Haukka, H.; Alexashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.

    2012-09-01

    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide crucial scientific data about the Martian atmospheric phenomena.

  13. SuperFormLab: showing SuperFormLab

    DEFF Research Database (Denmark)

    2013-01-01

    3D-printing in clay and ceramic objects shaped by your own sounds and movements! Digital form transferred via CNC-milling to ornamental ceramic wall-cladding. Brave New World… Students and their teacher at SuperFormLab, the new ceramic workshop of the School of Design at the Royal Danish Academy...... of Fine Arts in Copenhagen, will be showing results of their investigations into the potential of combining digital technologies with ceramic materials. It is now possible to shape the most complex mathematical, virtual 3D objects through the use of advanced software-programs. And more than that – you can...... now get these objects out of the computer and be able to hold and experience them with your hands. Even made in clay. At SuperFormLab, workshop for the new education in Ceramic Design at the School of Design, the integration of digital technologies in relation to the ceramic materials and techniques...

  14. Pluimvee met smaak: behoeften-inventarisaties

    NARCIS (Netherlands)

    Bos, A.P.; Janssen, A.P.H.M.; Leenstra, F.R.; Groot Koerkamp, P.W.G.

    2010-01-01

    Een integraal duurzaam productiesysteem voor vleespluimvee moet voldoen aan functies en eisen, die voortkomen uit behoeften. Deze behoeften van belanghebbenden worden op hoofdlijnen geïnventariseerd. Belanghebbenden zijn: het vleeskuiken, de pluimveehouder, het milieu, de burger als burger met

  15. Extraboard performance : TriMet case study.

    Science.gov (United States)

    2012-02-01

    This paper examines extraboard operations and management at TriMet, the transit provider for the Portland Oregon metropolitan area. The : extraboard consists of a pool of operators who fill open work resulting from absences and other causes. The pape...

  16. Overzicht van zuiveringsmethoden voor reststromen met bestrijdingsmiddelen

    NARCIS (Netherlands)

    Vulto, V.C.; Beltman, W.H.J.

    2007-01-01

    In verschillende landbouwsectoren ontstaan reststromen water met bestrijdingsmiddelen die kunnen leiden tot puntbelasting van het oppervlaktewater. Er is behoefte aan een overzicht van methoden die er zijn om bestrijdingsmiddelen te verwijderen uit reststromen. Dit rapport geeft een korte

  17. Mars MetNet Precursor Mission Status

    Science.gov (United States)

    Harri, A.-M.; Aleksashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.; Haukka, H.

    2013-09-01

    We are developing a new kind of planetary exploration mission for Mars in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

  18. Mars MetNet Mission Status

    Science.gov (United States)

    Harri, A.-M.; Aleksashkin, S.; Arruego, I.; Schmidt, W.; Genzer, M.; Vazquez, L.; Haukka, H.; Palin, M.; Nikkanen, T.

    2015-10-01

    New kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semihard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

  19. MMPM - Mars MetNet Precursor Mission

    Science.gov (United States)

    Harri, A.-M.; Schmidt, W.; Pichkhadze, K.; Linkin, V.; Vazquez, L.; Uspensky, M.; Polkko, J.; Genzer, M.; Lipatov, A.; Guerrero, H.; Alexashkin, S.; Haukka, H.; Savijarvi, H.; Kauhanen, J.

    2008-09-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. Prototyping of the payload instrumentation with final dimensions was carried out in 2003-2006.This huge development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development. To understand the behavior and dynamics of the Martian atmosphere, a wealth of simultaneous in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes. This will be performed by the Mars MetNet Mission. In addition to the science aspects the

  20. MetNet - Martian Network Mission

    Science.gov (United States)

    Harri, A.-M.

    2009-04-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The actual practical mission development work started in January 2009 with participation from various countries and space agencies. The scientific rationale and goals as well as key mission solutions will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. This development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development.

  1. Mars MetNet Mission Status

    Science.gov (United States)

    Harri, Ari-Matti; Aleksashkin, Sergei; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Haukka, Harri

    2015-04-01

    New kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. 1. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. 2. Scientific Payload The payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: 1. MetBaro Pressure device 2. MetHumi Humidity device 3. MetTemp Temperature sensors Optical devices: 1. PanCam Panoramic 2. MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer 3. DS Dust sensor The descent processes dynamic properties are monitored by a special 3-axis accelerometer combined with a 3-axis gyrometer. The data will be sent via auxiliary beacon antenna throughout the

  2. Recent results from Jefferson Lab

    International Nuclear Information System (INIS)

    Smith, E.

    2000-01-01

    Precision measurements of the structure of nucleons and nuclei in the regime of strong interaction QCD are now possible with the availability of high current polarized electron beams, polarized targets, and recoil polarimeters, in conjunction with modern spectrometers and detector instrumentation. The authors present some recent results from the Jefferson Lab on the charge and current distributions of nucleons and nuclei. They also review measurements which relate physics at small distances to the regime where strong interaction QCD is the relevant theory

  3. Designing inquiry learning spaces for online labs in the Go-Lab platform

    NARCIS (Netherlands)

    de Jong, Ton; Gillet, Dennis; Sotiriou, Sofoklis; Agogi, Ellinogermaniki; Zacharia, Zacharias

    2015-01-01

    The Go-Lab project (http://www.go-lab-project.eu/) aims to enable the integration of online labs through inquiry-based learning approaches into science classrooms. Through the use of an advanced plug and play technological solution the Go-Lab project opens up remote science laboratories, data

  4. Three-year-olds’ memory for a person met only once at the age of 12 months: Very long-term memory revealed by a late-manifesting novelty preference

    DEFF Research Database (Denmark)

    Kingo, Osman Skjold; Staugaard, Søren Risløv; Krøjgaard, Peter

    2014-01-01

    This study examined three-year-olds’ verbal and non-verbal memory for a person met only once after a 28 month interval. Children in the Test group (N=50) had participated in an earlier experiment at our lab at the age of 12 months where they met one of two possible experimenters. At this past event...

  5. LabVIEW 8 student edition

    CERN Document Server

    Bishop, Robert H

    2007-01-01

    For courses in Measurement and Instrumentation, Electrical Engineering lab, and Physics and Chemistry lab. This revised printing has been updated to include new LabVIEW 8.2 Student Edition. National Instruments' LabVIEW is the defacto industry standard for test, measurement, and automation software solutions. With the Student Edition of LabVIEW, students can design graphical programming solutions to their classroom problems and laboratory experiments with software that delivers the graphical programming capabilites of the LabVIEW professional version. . The Student Edition is also compatible with all National Instruments data acquisition and instrument control hardware. Note: The LabVIEW Student Edition is available to students, faculty, and staff for personal educational use only. It is not intended for research, institutional, or commercial use. For more information about these licensing options, please visit the National Instruments website at (http:www.ni.com/academic/)

  6. MetBaro - Pressure Device for Mars MetNet Lander

    Science.gov (United States)

    Haukka, Harri; Polkko, Jouni; Harri, Ari-Matti; Schmidt, Walter; Leinonen, Jussi; Genzer, Maria; Mäkinen, Teemu

    2010-05-01

    MetNet Mars Mission focused for Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetBaro is the pressure sensor of MetNet Lander designed to work on Martian surface. It is based on Barocap® technology developed by Vaisala, Inc. MetBaro is a capacitive type of sensing device where capasitor plates are moved by ambient pressure. MetBaro device consists of two pressure transducers including a total of 4 Barocap® sensor heads of high-stability and high-resolution types. The long-term stability of MetBaro is in order of 20…50 µBar and resolution a few µBar. MetBaro is small, lightweighed and has low power consumption. It weighs about 50g without wires and controlling FPGA, and consumes 15 mW of power. A similar device has successfully flown in Phoenix mission, where it performed months of measurements on Martian ground. Another device is also part of the Mars Science Laboratory REMS instrument (to be launched in 2011).

  7. MetHumi - Humidity Device for Mars MetNet Lander

    Science.gov (United States)

    Genzer, Maria; Polkko, Jouni; Harri, Ari-Matti; Schmidt, Walter; Leinonen, Jussi; Mäkinen, Teemu; Haukka, Harri

    2010-05-01

    MetNet Mars Mission focused for Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetHumi is the humidity sensor of MetNet Lander designed to work on Martian surface. It is based on Humicap® technology developed by Vaisala, Inc. MetHumi is a capacitive type of sensing device where an active polymer film changes capacitance as function of relative humidity. One MetHumi device package consists of one humidity transducer including three Humicap® sensor heads, an accurate temperature sensor head (Thermocap® by Vaisala, Inc.) and constant reference channels. MetHumi is very small, lightweighed and has low power consumption. It weighs only about 15 g without wires, and consumes 15 mW of power. MetHumi can make meaningful relative humidity measurements in range of 0 - 100%RH down to -70°C ambient temperature, but it survives even -135°C ambient temperature.

  8. C-MET overexpression and amplification in gliomas.

    Science.gov (United States)

    Kwak, Yoonjin; Kim, Seong-Ik; Park, Chul-Kee; Paek, Sun Ha; Lee, Soon-Tae; Park, Sung-Hye

    2015-01-01

    We investigated c-Met overexpression and MET gene amplification in gliomas to determine their incidence and prognostic significance. c-Met immunohistochemistry and MET gene fluorescence in situ hybridization were carried out on tissue microarrays from 250 patients with gliomas (137 grade IV GBMs and 113 grade II and III diffuse gliomas). Clinicopathological features of these cases were reviewed. c-Met overexpression and MET gene amplification were detected in 13.1% and 5.1% of the GBMs, respectively. All the MET-amplified cases showed c-Met overexpression, but MET amplification was not always concordant with c-Met overexpression. None of grade II and III gliomas demonstrated c-Met overexpression or MET gene amplification. Mean survival of the GBM patients with MET amplification was not significantly different from patients without MET amplification (P=0.155). However, GBM patients with c-Met overexpression survived longer than patients without c-Met overexpression (P=0.035). Although MET amplification was not related to poor GBM prognosis, it is partially associated with the aggressiveness of gliomas, as MET amplification was found only in grade IV, not in grade II and III gliomas. We suggest that MET inhibitor therapy may be beneficial in about 5% GBMs, which was the incidence of MET gene amplification found in the patients included in this study.

  9. Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis

    Directory of Open Access Journals (Sweden)

    Bozkaya Giray

    2012-09-01

    Full Text Available Abstract Background Hepatocyte growth factor (HGF induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration. Activation of HGF/c-Met signaling has been correlated with aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC. MUC1 is a transmembrane mucin, whose over-expression is reported in most cancers. Many of the oncogenic effects of MUC1 are believed to occur through the interaction of MUC1 with signaling molecules. To clarify the role of MUC1 in HGF/c-Met signaling, we determined whether MUC1 and c-Met interact cooperatively and what their role(s is in hepatocarcinogenesis. Results MUC1 and c-Met over-expression levels were determined in highly motile and invasive, mesenchymal-like HCC cell lines, and in serial sections of cirrhotic and HCC tissues, and these levels were compared to those in normal liver tissues. Co-expression of both c-Met and MUC1 was found to be associated with the differentiation status of HCC. We further demonstrated an interaction between c-Met and MUC1 in HCC cells. HGF-induced c-Met phosphorylation decreased this interaction, and down-regulated MUC1 expression. Inhibition of c-Met activation restored HGF-mediated MUC1 down-regulation, and decreased the migratory and invasive abilities of HCC cells via inhibition of β-catenin activation and c-Myc expression. In contrast, siRNA silencing of MUC1 increased HGF-induced c-Met activation and HGF-induced cell motility and invasion. Conclusions These findings indicate that the crosstalk between MUC1 and c-Met in HCC could provide an advantage for invasion to HCC cells through the β-catenin/c-Myc pathway. Thus, MUC1 and c-Met could serve as potential therapeutic targets in HCC.

  10. Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis.

    Science.gov (United States)

    Bozkaya, Giray; Korhan, Peyda; Cokaklı, Murat; Erdal, Esra; Sağol, Ozgül; Karademir, Sedat; Korch, Christopher; Atabey, Neşe

    2012-09-11

    Hepatocyte growth factor (HGF) induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration. Activation of HGF/c-Met signaling has been correlated with aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC). MUC1 is a transmembrane mucin, whose over-expression is reported in most cancers. Many of the oncogenic effects of MUC1 are believed to occur through the interaction of MUC1 with signaling molecules. To clarify the role of MUC1 in HGF/c-Met signaling, we determined whether MUC1 and c-Met interact cooperatively and what their role(s) is in hepatocarcinogenesis. MUC1 and c-Met over-expression levels were determined in highly motile and invasive, mesenchymal-like HCC cell lines, and in serial sections of cirrhotic and HCC tissues, and these levels were compared to those in normal liver tissues. Co-expression of both c-Met and MUC1 was found to be associated with the differentiation status of HCC. We further demonstrated an interaction between c-Met and MUC1 in HCC cells. HGF-induced c-Met phosphorylation decreased this interaction, and down-regulated MUC1 expression. Inhibition of c-Met activation restored HGF-mediated MUC1 down-regulation, and decreased the migratory and invasive abilities of HCC cells via inhibition of β-catenin activation and c-Myc expression. In contrast, siRNA silencing of MUC1 increased HGF-induced c-Met activation and HGF-induced cell motility and invasion. These findings indicate that the crosstalk between MUC1 and c-Met in HCC could provide an advantage for invasion to HCC cells through the β-catenin/c-Myc pathway. Thus, MUC1 and c-Met could serve as potential therapeutic targets in HCC.

  11. Double success for neutrino lab

    CERN Multimedia

    2010-01-01

    "The Gran Sasso National Laboratory in Italy is celebrating two key developments in the field of neutrino physics. Number one is the first ever detection, by the OPERA experiement, of possible tau neutrino that has switched its identity from a muon neutrino as it travelled form its origins at CERN in Switzerland to the Italian lab. Number two is the successful start-up of the ICARUS detector, which, like OPERA, is designed to study neutrinos that "oscillate" between types" (0.5 pages)

  12. Remote Lab for Robotics Applications

    Directory of Open Access Journals (Sweden)

    Robinson Jiménez

    2018-01-01

    Full Text Available This article describes the development of a remote lab environment used to test and training sessions for robotics tasks. This environment is made up of the components and devices based on two robotic arms, a network link, Arduino card and Arduino shield for Ethernet, as well as an IP camera. The remote laboratory is implemented to perform remote control of the robotic arms with visual feedback by camera, of the robots actions, where, with a group of test users, it was possible to obtain performance ranges in tasks of telecontrol of up to 92%.

  13. Laser safety in the lab

    CERN Document Server

    Barat, Ken L

    2012-01-01

    There is no more challenging setting for laser use than a research environment. In almost every other setting the laser controls count on engineering controls, and human exposure is kept to a minimum. In research, however, the user often manipulates the optical layout and thereby places him or herself in peril, but this does not mean that accidents and injury are unavoidable. On the contrary, laser accidents can be avoided by following a number of simple approaches. [i]Laser Safety in the Lab[/i] provides the laser user and laser safety officer with practical guidelines from housekeeping to ey

  14. Digital media labs in libraries

    CERN Document Server

    Goodman, Amanda L

    2014-01-01

    Families share stories with each other and veterans reconnect with their comrades, while teens edit music videos and then upload them to the web: all this and more can happen in the digital media lab (DML), a gathering of equipment with which people create digital content or convert content that is in analog formats. Enabling community members to create digital content was identified by The Edge Initiative, a national coalition of leading library and local government organizations, as a library technology benchmark. Surveying academic and public libraries in a variety of settings and sharing a

  15. Recent results from Jefferson Lab

    International Nuclear Information System (INIS)

    Volker D. Burkert

    1999-01-01

    Recent results on studies of the structure of nucleons and nuclei in the regime of strong interaction QCD are discussed. Use of high current polarized electron beams, polarized targets, and recoil polarimeters, in conjunction with modern spectrometers and detector instrumentation allow much more detailed studies of nucleon and nuclear structure than has been possible in the past. The CEBAF accelerator at Jefferson Lab was build to study the internal structure of hadrons in a regime where confinement is important and strong interaction QCD is the relevant theory. They author discusses how the first experiments already make significant contributions towards an improved understanding of hadronic structure

  16. Recent Results from Jefferson Lab

    International Nuclear Information System (INIS)

    Volker Burkert

    2000-03-01

    Recent results on studies of the structure of nucleons and nuclei in the regime of strong interaction QCD are discussed. Use of high current polarized electron beams, polarized targets, and recoil polarimeters, in conjunction with modern spectrometers and detector instrumentation allow much more detailed studies of nucleon and nuclear structure than has been possible in the past. The CEBAF accelerator at Jefferson Lab was built to study the internal structure of hadrons in a regime where confinement is important and strong interaction QCD is the relevant theory. I discuss how the first experiments already make significant contributions towards an improved understanding of hadronic structure

  17. A green chemistry lab course

    International Nuclear Information System (INIS)

    Rank, J.; Lenoir, D.; Bahadir, M.; Koning, B.

    2006-01-01

    The traditional course content of chemistry classes must change to achieve better awareness of the important issues of sustainability in chemistry within the next generation of professional chemists. To provide the necessary material for the organic chemistry teaching lab course, which is part of almost all study programs in chemistry, material was developed and collected (http://www.oc-praktikum.de/en) that allows students and teachers to assess reactions beyond the experimental set up, reaction mechanism and chemical yield. Additional parameters like atom economy of chemical transformations, energy efficiency, and questions of waste, renewable feed stocks, toxicity and ecotoxicity, as well as the safety measures for the chemicals used are discussed. (author)

  18. MetBaro - Pressure Instrument for Mars MetNet Lander

    Science.gov (United States)

    Polkko, J.; Haukka, H.; Harri, A.-M.; Schmidt, W.; Leinonen, J.; Mäkinen, T.

    2009-04-01

    THE METNET MISSION FOCUSED ON THE Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetBaro is the pressure instrument of MetNet Lander designed to work on Martian surface. It is based on Barocap® technology developed by Vaisala, Inc. MetBaro is a capacitic type of sensing device where capasitor plates are moved by ambient pressure. MetBaro device consists of two pressure transducers including a total of 6 Barocap® sensor heads of high-stability and high-resolution types. The long-term stability of MetBaro is in order of 20…50 µBar and resolution a few µBar. MetBaro is small, lightweighed and has low power consumption. It weighs about 50g without wires and controlling FPGA, and consumes 15 mW of power. A similar device has successfully flown in Phoenix mission, where it performed months of measurements on Martian ground. Another device is also part of the Mars Science Laboratory REMS instrument (to be launched in 2011).

  19. Groen proceswater: zuivering brouwerijprocesafvalwater met microalgen

    NARCIS (Netherlands)

    Dijk, van W.; Weide, van der R.Y.; Kroon, A.

    2016-01-01

    In 2012 is het project Groen Proceswater gestart. Hierin worden de mogelijkheden van zuivering van brouwerijprocesafvalwater met behulp van microalgen onderzocht. Dit is gedaan in een samenwerkingsverband van Heineken Nederland BV, Algae Food & Fuel en WUR-ACRRES. De resultaten behaald in 2012

  20. Allergische consument is tevreden met Santana

    NARCIS (Netherlands)

    Maas, van der M.P.; Schenk, M.F.

    2008-01-01

    Nederland had twee jaar geleden de primeur: Santana, een hyperallergeen appelras voor mensen met appelallergie. Wageningen UR heeft de ervaringen van de consumenten over 2006 en 2007 onderzocht. De vermindering van de allergische reactie is ongeveer volgens verwachting en de tevredenheid blijkt hoog

  1. Evangelisch Commando, onze omgamg met de buitenkerkelijke ...

    African Journals Online (AJOL)

    Test

    Of J. en E. dus interkerklik is, bly 'n vraag! Die gedeelte oor die „Oorzaken van buitenkerklijkheid is prikkelend en interessant. Die vraag is net of dit nie nog dieper gesoek moet word, nl. in die herontwaking van die Heidendom wat sig sins die Renaissance hardnekkig deur sit met die outonomie van die mens in die sentrum.

  2. Hindernisse met betrekking tot jeugsportdeelname | Coetzee | South ...

    African Journals Online (AJOL)

    Hindernisse met betrekking tot jeugsportdeelname. Zonja Coetzee, Mercia Coetzee, Karel Botha. Abstract. The purpose of this study was to assess barriers or constraints that can preclude or limit the sport participation of high school pupils in the Potchefstroom district. Four hundred and seventy eight pupils (211 boys and ...

  3. Met gezonde bijen naar de heide

    NARCIS (Netherlands)

    Cornelissen, B.; Calis, J.

    2010-01-01

    Op 22 maart 2010 kwam een bont gezelschap van bijenhouders van ABTB, ANI en NBV bijeen in Hoenderloo. Het onderwerp die avond was de vraag: “Hoe combineer ik varroabestrijding met de heidedracht?” Hieronder het antwoord en wel in de vorm van de basisprincipes van varroa bestrijding plus een concrete

  4. Varroabestrijding met bijenbroed als mijtenval (2)

    NARCIS (Netherlands)

    Calis, J.; Beetsma, J.; Boot, W.J.; Eijnde, van den J.; Ruijter, de A.

    1994-01-01

    Bij deze bestrijdingsmethode worden belegde darreraten uit een moergoede veger overgehangen naar het moerloze en later broedloze hoofdvolk. Hier worden de mijten die zich op de bijen bevinden gevangen. Nadat de laatste darreraat uit een hoofdvolk is verwijderd, wordt het bijenvolk met Perizine

  5. Beeldreconstructie in MRI met compressed sensing

    NARCIS (Netherlands)

    van Leeuwen, T.

    Philips Healthcare is een van de grootste fabrikanten van MRI-scanners ter wereld en is geïnteresseerd in het gebruik van compressed sensing-technieken om MRI-scans te versnellen. Tijdens de Studieweek Wiskunde met de Industrie 2015 in Utrecht vroeg Philips of en hoe patiënt-specifieke informatie

  6. Nieuwe ontwikkelingen met roofmijten tegen spint

    NARCIS (Netherlands)

    Dorresteijn, W.; Blok, de J.J.

    2008-01-01

    Bonenspintmijt is een lastig te bestrijden plaag. Een aantal boomkwekers heeft goede ervaringen met het inzetten van roofmijten tegen deze plaag. Nieuwe ontwikkelingen, zoals een lagere prijs en andere methoden van inzetten, kunnen ervoor zorgen dat deze vorm van geïntegreerde bestrijding steeds

  7. The cleverest man I never met

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 96; Issue 5. The cleverest man I never met. PATRICK BATESON. HALDANE AT 125 Volume 96 Issue 5 November 2017 pp 801-804. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/jgen/096/05/0801-0804. Keywords. J. B. S. Haldane ...

  8. A brief report on mets system

    Digital Repository Service at National Institute of Oceanography (India)

    Fernandes, W.A.

    Mets system is basically a gas monitoring system, used for the detection of underwater gas. The system consists of a sensor, datalogger and energy module. The sensor works on the diffusion techniques. The system can be deployed to a water depth...

  9. Onkruidbestrijding met Basta 200 in zomerbloemen

    NARCIS (Netherlands)

    Bulle, A.A.E.

    2010-01-01

    Onkruidbestrijding in zomerbloemen is een stuk lastiger geworden sinds het middel Gramoxone, met als werkzame stof paraquat-dichloride, niet meer is toegelaten. In een eerder onderzoek is onderzocht welke middelen als alternatief voor paraquat-dichloride kunnen worden gebruikt in de winter en het

  10. Behandeling non-vitale pulpa met formocresol

    NARCIS (Netherlands)

    Wijk, Pieter Harm

    1971-01-01

    Het principe van de endodontische behandeling volgens de richtlijnen van De Boer is gebaseerd op de gedachte dat het niet nodig is het gehele wortelkanaal te reinigen, mits men er voor zorgt dat de achtergelaten noxen met behulp van een chemischestof - in dit geval formaldehyde - onschadelijk worden

  11. Student Learning Outcomes and Attitudes When Biotechnology Lab Partners Are of Different Academic Levels

    Science.gov (United States)

    Miller, Heather B.; Witherow, D. Scott; Carson, Susan

    2012-01-01

    The North Carolina State University Biotechnology Program offers laboratory-intensive courses to both undergraduate and graduate students. In “Manipulation and Expression of Recombinant DNA,” students are separated into undergraduate and graduate sections for the laboratory, but not the lecture, component. Evidence has shown that students prefer pairing with someone of the same academic level. However, retention of main ideas in peer learning environments has been shown to be greater when partners have dissimilar abilities. Therefore, we tested the hypothesis that there will be enhanced student learning when lab partners are of different academic levels. We found that learning outcomes were met by both levels of student, regardless of pairing. Average undergraduate grades on every assessment method increased when undergraduates were paired with graduate students. Many of the average graduate student grades also increased modestly when graduate students were paired with undergraduates. Attitudes toward working with partners dramatically shifted toward favoring working with students of different academic levels. This work suggests that offering dual-level courses in which different-level partnerships are created does not inhibit learning by students of different academic levels. This format is useful for institutions that wish to offer “boutique” courses in which student enrollment may be low, but specialized equipment and faculty expertise are needed. PMID:22949428

  12. Kwantitatieve massaspectrometrie van Clenbuterol met behulp van isotoopverdunning

    NARCIS (Netherlands)

    Traag, W.A.; Bennekom, van E.O.; Weseman, J.M.; Kienhuis, P.G.M.; Tuinstra, L.G.M.Th.

    1989-01-01

    Om de toepassing van massaspectrometrie met behulp van isotoopverdunning in urine, vlees en lever te onderzoeken is een aantal experimenten uitgevoerd met de 'Hewlett-Packard Hass Selective Detector' (Electron Impact). Ook zijn met Finnigan 4500 aanvullende experimenten (Chemical Ionisation)

  13. Jefferson Lab, a status report

    International Nuclear Information System (INIS)

    Thomas Jefferson National Accelerator Facility (Jefferson Lab; formerly known as CEBAF), operates a 4 GeV, 200 microA continuous wave (CW) electron accelerator that re-circulates the beam five times through two superconducting 400 MeV linacs. Electrons can be extracted from any of the five recirculation passes and beam can be simultaneously delivered to the three experimental halls. As the commissioning stage nears completion, the accelerator is becoming a fully operational machine. Experiments in Hall C have been underway since November 1995 with beam powers of over 300 kW at various energies. Hall A has received beam for spectrometer commissioning, while Hall B is expected to receive its first beam in the fall of 1996. Accelerator availability of greater than 70% during physics runs and excellent beam quality have contributed to making Jefferson Lab a world class laboratory for accelerator-based electromagnetic nuclear physics. With the high performance of the superconducting RF cavities, machine upgrades to 6 GeV, and eventually 8 to 10 GeV are now in the planning stages. Operational and commissioning details concerning all aspects of the machine will be discussed

  14. Jefferson Lab, a status report

    International Nuclear Information System (INIS)

    Dunham, B.M.

    1996-01-01

    Thomas Jefferson National Accelerator Facility (Jefferson Lab; formerly known as CEBAF), operates a 4 GeV, 200 μA continuous wave (CW) electron accelerator that re-circulates the beam five times through two superconducting 400 MeV linacs. Electrons can be extracted from any of the five recirculation passes and beam can be simultaneously delivered to the three experimental halls. As the commissioning stage nears completion, the accelerator is becoming a fully operational machine. Experiments in Hall C have been underway since November 1995 with beam powers of over 300 kW at various energies. Hall A has received beam for spectrometer commissioning, while Hall B is expected to receive its first beam in the fall of 1996. Accelerator availability of greater than 70% during physics runs and excellent beam quality have contributed to making Jefferson Lab a world class laboratory for accelerator-based electromagnetic nuclear physics. With the high performance of the superconducting RF cavities, machine upgrades to 6 GeV, and eventually 8 to 10 GeV are now in the planning stages. Operational and commissioning details concerning all aspects of the machine will be discussed. (author)

  15. Jefferson Lab, a status report

    International Nuclear Information System (INIS)

    Dunham, B.M.

    1996-01-01

    Thomas Jefferson National Accelerator Facility (Jefferson Lab; formerly known as CEBAF), operates a 4 GeV, 200 microA continuous wave (CW) electron accelerator that re-circulates the beam five times through two superconducting 400 MeV linacs. Electrons can be extracted from any of the five recirculation passes and beam can be simultaneously delivered to the three experimental halls. As the commissioning stage nears completion, the accelerator is becoming a fully operational machine. Experiments in Hall C have been underway since November 1995 with beam powers of over 300 kW at various energies. Hall A has received beam for spectrometer commissioning, while Hall B is expected to receive its first beam in the fall of 1996. Accelerator availability of greater than 70% during physics runs and excellent beam quality have contributed to making Jefferson Lab a world class laboratory for accelerator-based electromagnetic nuclear physics. With the high performance of the superconducting RF cavities, machine upgrades to 6 GeV, and eventually 8 to 10 GeV are now in the planning stages. Operational and commissioning details concerning all aspects of the machine will be discussed

  16. MatLab Script and Functional Programming

    Science.gov (United States)

    Shaykhian, Gholam Ali

    2007-01-01

    MatLab Script and Functional Programming: MatLab is one of the most widely used very high level programming languages for scientific and engineering computations. It is very user-friendly and needs practically no formal programming knowledge. Presented here are MatLab programming aspects and not just the MatLab commands for scientists and engineers who do not have formal programming training and also have no significant time to spare for learning programming to solve their real world problems. Specifically provided are programs for visualization. The MatLab seminar covers the functional and script programming aspect of MatLab language. Specific expectations are: a) Recognize MatLab commands, script and function. b) Create, and run a MatLab function. c) Read, recognize, and describe MatLab syntax. d) Recognize decisions, loops and matrix operators. e) Evaluate scope among multiple files, and multiple functions within a file. f) Declare, define and use scalar variables, vectors and matrices.

  17. MET and Small-Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Francesco Gelsomino

    2014-10-01

    Full Text Available Small-cell lung cancer (SCLC is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC.

  18. MET and Small-Cell Lung Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Gelsomino, Francesco, E-mail: francesco.gelsomino@istitutotumori.mi.it [Medical Oncology Unit 1, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milano (Italy); Rossi, Giulio [Operative Unit of Pathology, Azienda Ospedaliero-Universitaria Policlinico, Via del Pozzo 71, 41124 Modena (Italy); Tiseo, Marcello [Medical Oncology Unit, Azienda Ospedaliero-Universitaria, Viale A. Gramsci 14, 43126 Parma (Italy)

    2014-10-13

    Small-cell lung cancer (SCLC) is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC.

  19. Die Calvinistiese Sondagbeskouing met spesiale verwysing na ...

    African Journals Online (AJOL)

    omver te werp. Aan die ander kant het die orde en vrede in die kerk dit wel ook nodig gemaak om 'n dag vir gebruik van die diens van die Here af te sonder. Calvyn se insigte in verband met die oorgang van die Sabbat na die Sondag, is die insigte wat as die eg reformatoriese behoue gebly het. Haitjema (1961:249) sê in.

  20. Famed lab seeks big grid

    CERN Document Server

    Lillington, K

    2001-01-01

    DUBLIN, Ireland -- CERN, the famed Swiss high-energy particle physics lab, has a problem. It's about to start generating more data than any computer or network anywhere in the world is able to analyze. That prospect has led CERN to drive a major European project to create a vast "grid" research network of computers across Europe. When completed, the 10 million euro, Linux-based endeavor called DataGRID, will become a principal European computing resource for researchers of many disciplines. "I believe grid computing will revolutionize the way we compute, in much the same way as the World Wide Web and Internet changed the way we communicate," said John Ellis, a theoretical physicist and adviser to the director general of CERN.

  1. Metáfora y estructura conceptual

    Directory of Open Access Journals (Sweden)

    Emilia Castaño

    2012-01-01

    Full Text Available La lingüística cognitiva siempre ha argumentado que la metáfora no pertenece exclusivamente al lenguaje, sino que es una competencia que se basa en la habilidad humana de concebir un dominio de experiencia en términos de otro. Entendida así, la metáfora no puede ser otra cosa que un fenómeno conceptual. No obstante, pocos adeptos de la lingüística cognitiva han concentrados sus esfuerzos en catalogar manifestaciones metafóricas en ámbitos no lingüísticos. En este trabajo, sugerimos que es factible encontrar pruebas de que la metáfora es un proceso conceptual y, como tal, se manifiesta en esferas que no son estrictamente lingüísticas. Para ello, aportamos un seguido de evidencias muy diversas, como por ejemplo su papel en el razonamiento lógico-matemático de los niños en la fase preoperacional del desarrollo cognitivo, la programación de interfaces para aplicaciones informáticas y los resultados de tres estudios empíricos realizados recientemente en el campo  de la psicología cognitiva que analizan los efectos whorfianos en la conceptualización del tiempo y los efectos del espacio en la memoria emocional.

  2. Could the organ shortage ever be met?

    Science.gov (United States)

    Levitt, Mairi

    2015-01-01

    The organ shortage is commonly presented as having a clear solution, increase the number of organs donated and the problem will be solved. In the light of the Northern Ireland Assembly's consultation on moving to an opt-out organ donor register this article focuses on the social factors and complexities which impact strongly on both the supply of, and demand for, transplantable organs. Judging by the experience of other countries presumed consent systems may or may not increase donations but have not met demand. Donation rates have risen considerably in all parts of the UK recently but there is also an increasing demand for organs. Looking at international donation rates and attitudes, future demand for organs and education on donation, the question is whether the organ shortage could ever be met. The increase in longevity, in rates of diabetes and obesity and in alcohol related liver disease all contribute both to increased demand for transplants, and re-transplants, and a reduction in the number of usable organs. It is unlikely that demand could ever be met, since, if supply was unlimited, the focus would move to financial resources and competing demands on the health care budget in a publicly funded health system. These factors point to the need to focus on ways of reducing, or at least stabilizing, demand where lifestyle factors contribute to the underlying disease.

  3. Innovations in STEM education: the Go-Lab federation of online labs

    NARCIS (Netherlands)

    de Jong, Anthonius J.M.; Sotiriou, Sofoklis; Gillet, Dennis

    2014-01-01

    The Go-Lab federation of online labs opens up virtual laboratories (simulation), remote laboratories (real equipment accessible at distance) and data sets from physical laboratory experiments (together called “online labs”) for large-scale use in education. In this way, Go-Lab enables inquiry-based

  4. The PNNL Lab Homes Experimental Plan, FY12-FY15

    Energy Technology Data Exchange (ETDEWEB)

    Widder, Sarah H; Parker, Graham B; Baechler, Michael C

    2012-05-01

    The PNNL lab homes (http://labhomes.pnnl.gov/ ) are two manufactured homes recently installed immediately south of the 6th Street Warehouse on the PNNL Richland, WA campus that will serve as a project test bed for DOE, PNNL and its research partners who aim to achieve highly energy efficient and grid-responsive homes. The PNNL Lab Homes project is the first of its kind in the Pacific Northwest region. The Energy & Environment Directorate at PNNL, working with multiple sponsors, will use the identical 1,500 square-foot homes for experiments focused on reducing energy use and peak demand. Research and demonstration primarily will focus on retrofit technologies, and the homes will offer a unique, side-by-side ability to test and compare new ideas and approaches that are applicable to site-built as well as manufactured homes. The test plan has the following objectives: • To define a retrofit solution packages for moderate to cold climates that can be cost effectively deployed in the Pacific NW to save 50% of the energy needs of a typical home while enhancing the comfort and indoor air quality. The retrofit strategies would also lower the peak demands on the grid. • To leverage the unique opportunity in the lab homes to reach out to researchers, industry, and other interested parties in the building science community to collaborate on new smart and efficient solutions for residential retrofits. • To increase PNNL’s visibility in the area of buildings energy efficiency based on the communication strategy and presentation of the unique and impactful data generated in the lab homes. This document describes the proposed test plan for the lab homes to achieve these goals, through FY15. The subsequent sections will provide a brief description of each proposed experiment, summarize the timing of the experiment (including any experiments that may be run in parallel, and propose potential contributors and collaborators. For those experiments with funding information

  5. Innovation - A view from the Lab

    Science.gov (United States)

    The USDA Ag Lab in Peoria helps bridge the gap between agricultural producers and commercial manufacturers. In 2015, the Ag Lab, officially known as the Agricultural Research Service (ARS) National Center for Agricultural Utilization Research (NCAUR), is celebrating 75 years of research in Peoria. T...

  6. Latest results from FROST at Jefferson Lab

    Directory of Open Access Journals (Sweden)

    Ritchie B.G.

    2014-06-01

    Full Text Available The spectrum of broad and overlapping nucleon excitations can be greatly clarified by use of a polarized photon beam incident on a polarized target in meson photoproduction experiments. At Jefferson Lab, a program of such measurements has made use of the Jefferson Lab FROzen Spin Target (FROST. An overview of preliminary results are presented.

  7. Latest results from FROST at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    Ritchie, Barry G. [Arizona State University

    2014-06-01

    The spectrum of broad and overlapping nucleon excitations can be greatly clarified by use of a polarized photon beam incident on a polarized target in meson photoproduction experiments. At Jefferson Lab, a program of such measurements has made use of the Jefferson Lab FROzen Spin Target (FROST). An overview of preliminary results are presented.

  8. Programming Arduino with LabVIEW

    CERN Document Server

    Schwartz, Marco

    2015-01-01

    If you already have some experience with LabVIEW and want to apply your skills to control physical objects and make measurements using the Arduino sensor, this book is for you. Prior knowledge of Arduino and LabVIEW is essential to fully understand the projects detailed in this book.

  9. Supercharging Lessons with a Virtual Lab

    Science.gov (United States)

    Stewart, Jefferson; Vincent, Daniel

    2013-01-01

    The authors describes their experiences incorporating the virtual lab into a simple circuit lesson during an energy unit in a sixth-grade class. The lesson included a hands-on group experiment using wire, batteries, and light bulbs to make a circuit and an online simulation, using a virtual lab. Class discussions, student inquiries, and the study…

  10. Assembly Manual for the Berkeley Lab Cosmic Ray Detector

    CERN Document Server

    Collier, M

    2002-01-01

    The Berkeley Lab Cosmic Ray Detector consists of 3 main components that must be prepared separately before they can be assembled. These components are the scintillator, circuit board, and casing. They are described in the main sections of this report, which may be completed in any order. Preparing the scintillator paddles involves several steps--cutting the scintillator material to the appropriate size and shape, preparing and attaching Lucite cookies (optional), polishing the edges, gluing the end to the photomultiplier tube (optional), and wrapping the scintillator. Since the detector has 2 paddles, each of the sections needs to be repeated for the other paddle.

  11. Assembly Manual for the Berkeley Lab Cosmic Ray Detector

    International Nuclear Information System (INIS)

    Collier, Michael

    2002-01-01

    The Berkeley Lab Cosmic Ray Detector consists of 3 main components that must be prepared separately before they can be assembled. These components are the scintillator, circuit board, and casing. They are described in the main sections of this report, which may be completed in any order. Preparing the scintillator paddles involves several steps--cutting the scintillator material to the appropriate size and shape, preparing and attaching Lucite cookies (optional), polishing the edges, gluing the end to the photomultiplier tube (optional), and wrapping the scintillator. Since the detector has 2 paddles, each of the sections needs to be repeated for the other paddle

  12. Assembly Manual for the Berkeley Lab Cosmic Ray Detector

    Energy Technology Data Exchange (ETDEWEB)

    Collier, Michael

    2002-12-17

    The Berkeley Lab Cosmic Ray Detector consists of 3 main components that must be prepared separately before they can be assembled. These components are the scintillator, circuit board, and casing. They are described in the main sections of this report, which may be completed in any order. Preparing the scintillator paddles involves several steps--cutting the scintillator material to the appropriate size and shape, preparing and attaching Lucite cookies (optional), polishing the edges, gluing the end to the photomultiplier tube (optional), and wrapping the scintillator. Since the detector has 2 paddles, each of the sections needs to be repeated for the other paddle.

  13. Exploring linear algebra labs and projects with Mathematica

    CERN Document Server

    Arangala, Crista

    2014-01-01

    Matrix Operations Lab 0: An Introduction to Mathematica Lab 1: Matrix Basics and Operations Lab 2: A Matrix Representation of Linear Systems Lab 3: Powers, Inverses, and Special Matrices Lab 4: Graph Theory and Adjacency Matrices Lab 5: Permutations and Determinants Lab 6: 4 x 4 Determinants and Beyond Project Set 1 Invertibility Lab 7: Singular or Nonsingular? Why Singularity Matters Lab 8: Mod It Out, Matrices with Entries in ZpLab 9: It's a Complex World Lab 10: Declaring Independence: Is It Linear? Project Set 2 Vector Spaces Lab 11: Vector Spaces and SubspacesLab 12: Basing It All on Just a Few Vectors Lab 13: Linear Transformations Lab 14: Eigenvalues and Eigenspaces Lab 15: Markov Chains, An Application of Eigenvalues Project Set 3 Orthogonality Lab 16: Inner Product Spaces Lab 17: The Geometry of Vector and Inner Product SpacesLab 18: Orthogonal Matrices, QR Decomposition, and Least Squares Regression Lab 19: Symmetric Matrices and Quadratic Forms Project Set 4 Matrix Decomposition with Applications L...

  14. 42 CFR 136.406 - Under what circumstances will the minimum standards of character be considered to be met?

    Science.gov (United States)

    2010-10-01

    ... of character be considered to be met? 136.406 Section 136.406 Public Health PUBLIC HEALTH SERVICE... minimum standards of character be considered to be met? The minimum standards of character shall be... with the individual's references and places of employment and education; (b) A criminal history...

  15. Lab-on-a-Chip

    Science.gov (United States)

    2004-01-01

    Labs on chips are manufactured in many shapes and sizes and can be used for numerous applications, from medical tests to water quality monitoring to detecting the signatures of life on other planets. The eight holes on this chip are actually ports that can be filled with fluids or chemicals. Tiny valves control the chemical processes by mixing fluids that move in the tiny channels that look like lines, connecting the ports. Scientists at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama designed this chip to grow biological crystals on the International Space Station. Through this research, they discovered that this technology is ideally suited for solving the challenges of the Vision for Space Exploration. For example, thousands of chips the size of dimes could be loaded on a Martian rover looking for biosignatures of past or present life. Other types of chips could be placed in handheld devices used to monitor microbes in water or to quickly conduct medical tests on astronauts. (NASA/MSFC/D.Stoffer)

  16. Designing Viable Business Models for Living Labs

    Directory of Open Access Journals (Sweden)

    Bernhard R. Katzy

    2012-09-01

    Full Text Available Over 300 regions have integrated the concept of living labs into their economic development strategy since 2006, when the former Finnish Prime Minister Esko Aho launched the living lab innovation policy initiative during his term of European presidency. Despite motivating initial results, however, success cases of turning research into usable new products and services remain few and uncertainty remains on what living labs actually do and contribute. This practitioner-oriented article presents a business excellence model that shows processes of idea creation and team mobilization, new product development, user involvement, and entrepreneurship through which living labs deliver high-potential investment opportunities. Customers of living labs are identified as investors such as venture capitalists or industrial firms because living labs can generate revenue from them to create their own sustainable business model. The article concludes that living labs provide extensive support “lab” infrastructure and that it remains a formidable challenge to finance it, which calls for a more intensive debate.

  17. Software Energy Footprint Lab (SEFlab). Towards the use of energy efficient software applications; Software Energy Footprint Lab (SEFlab). Naar toepassing van energiezuinige softwareapplicaties

    Energy Technology Data Exchange (ETDEWEB)

    Merkus, B.; Hoekstra, E.; Van den Hoed, R. [Hogeschool van Amsterdam HvA, Amsterdam (Netherlands)

    2012-12-15

    The Energy Footprint Software Lab (SEFLab) allows researchers to give a detailed overview of the energy consumption of the hardware and software with a combination of advanced techniques in a controlled environment. The project comprised four main activities: (1) professionalization of measurement setup and test protocol; (2) Concrete calculation of two software applications as case studies; (3) an (internal) stakeholder analysis; and (4) dissemination of results [Dutch] Het Software Energy Footprint Lab (SEFLab) stelt onderzoekers in staat met een combinatie van geavanceerde technieken in een gecontroleerde omgeving een gedetailleerd beeld van het energieverbruik van de hardware n.a.v. software-gebruik te meten. Binnen het project stonden vier activiteiten centraal: (1) professionalisering van meetopstelling en testprotocol; (2) concrete doorrekening van twee softwareapplicaties als cases; (3) een (interne) stakeholder-analyse; en (4) disseminatie van resultaten.

  18. Baseball Physics: A New Mechanics Lab

    Science.gov (United States)

    Wagoner, Kasey; Flanagan, Daniel

    2018-05-01

    The game of baseball provides an interesting laboratory for experimenting with mechanical phenomena (there are many good examples in The Physics Teacher, available on Professor Alan Nathan's website, and discussed in Physics of Baseball & Softball). We have developed a lab, for an introductory-level physics course, that investigates many of these phenomena. The lab uses inexpensive, readily available equipment such as wooden baseball bats, baseballs, and actual Major League Baseball data. By the end of the lab, students have revisited many concepts they learned earlier in the semester and come away with an understanding of how to put seemingly disparate ideas together to analyze a fun sport.

  19. C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes.

    Science.gov (United States)

    Siddiqui, Shahid S; Loganathan, Sivakumar; Krishnaswamy, Soundararajan; Faoro, Leonardo; Jagadeeswaran, Ramasamy; Salgia, Ravi

    2008-06-01

    Cancers typically harbour several mutant forms of key cellular genes that contribute to its complex phenotype. Our lab has previously identified gain-of-function mutations in some of the receptor tyrosine kinases such as c-Met in lung cancer. In order to investigate the mutant gene in the context of a whole organism, the current choice of in vivo model is limited to the mouse. To rapidly screen the functional aspects of mutant forms of c-Met detected in lung cancer, we used the nematode C. elegans as the model organism. Transgenic worms were generated that harbour wild type or the frequently seen mutant forms of c-Met in lung cancer (c-MetR988C and c-MetT1010I). Expression of the mutant human c-Met forms in C. elegans consistently resulted in significantly low fecundity and abnormal vulval development characterized by hyperplasia. Interestingly, exposure of c-Met mutant transgenic worms to nicotine resulted in enhanced abnormal vulval development, fecundity and locomotion. Our studies provide first evidence that human c-Met mutations can be studied in C. elegans, and that carcinogens can enhance mutant c-Met function expressed in C. elegans transgenic animals. We therefore propose the use of C. elegans as a model to rapidly assess the role of cancer specific gene mutations in the context of a whole organism.

  20. Labs not in a lab: A case study of instructor and student perceptions of an online biology lab class

    Science.gov (United States)

    Doiron, Jessica Boyce

    Distance learning is not a new phenomenon but with the advancement in technology, the different ways of delivering an education have increased. Today, many universities and colleges offer their students the option of taking courses online instead of sitting in a classroom on campus. In general students like online classes because they allow for flexibility, the comfort of sitting at home, and the potential to save money. Even though there are advantages to taking online classes, many students and instructors still debate the effectiveness and quality of education in a distant learning environment. Many universities and colleges are receiving pressure from students to offer more and more classes online. Research argues for both the advantages and disadvantages of online classes and stresses the importance of colleges and universities weighing both sides before deciding to adopt an online class. Certain classes may not be suitable for online instruction and not all instructors are suitable to teach online classes. The literature also reveals that there is a need for more research on online biology lab classes. With the lack of information on online biology labs needed by science educators who face the increasing demand for online biology labs, this case study hopes to provide insight into the use of online biology lab classes and the how students and an instructor at a community college in Virginia perceive their online biology lab experience as well as the effectiveness of the online labs.

  1. The Design:Lab as platform in participatory design research

    DEFF Research Database (Denmark)

    Binder, Thomas; Brandt, Eva

    2008-01-01

    The notion of laboratory or simply 'lab' has become popular in recent years in areas outside science and technology development. Learning Labs, Innovation Labs, Usability Labs, Media and Communication Labs and even Art Labs designate institutions or fora dedicated to change and experimentation...... as others have frequently used other metaphors like workshop, studio or atelier in design research. In this article we will argue that the laboratory metaphor is particularly suitable and useful for the design:lab, and we will give examples of how we have worked with the design:lab as a platform...

  2. MET Standards for Electro-Technical Officers

    Directory of Open Access Journals (Sweden)

    Janusz Mindykowski

    2014-12-01

    Full Text Available The paper deals with one of the most important changes in the STCW 1978 as amended in 2010 Convention, from the point of view of the watchkeeping officers responsible for control, maintenance, diagnostic and repair of electrical and electronic installations on board of ships. Some reasons, why the MET Standards for Electro-Technical had to be developed and implemented are shortly analyzed and described. A legislative way towards and a short description of the minimum standards competence for ETO are presented. Next, new tools supporting ETO’s standards implementation are appointed. Finally, the future works as well as the concluding remarks concerning discussed issue are formulated and commented on.

  3. Tidal analysis of Met rocket wind data

    Science.gov (United States)

    Bedinger, J. F.; Constantinides, E.

    1976-01-01

    A method of analyzing Met Rocket wind data is described. Modern tidal theory and specialized analytical techniques were used to resolve specific tidal modes and prevailing components in observed wind data. A representation of the wind which is continuous in both space and time was formulated. Such a representation allows direct comparison with theory, allows the derivation of other quantities such as temperature and pressure which in turn may be compared with observed values, and allows the formation of a wind model which extends over a broader range of space and time. Significant diurnal tidal modes with wavelengths of 10 and 7 km were present in the data and were resolved by the analytical technique.

  4. Metástasis hipofisaria Hypophyseal metastasis

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Yanes Quesada

    2009-04-01

    Full Text Available mayoría son lesiones silentes descubiertas accidentalmente en las autopsia. La aparición de metástasis sintomáticas es, en cambio, excepcional. DESARROLLO: se describen aquí los hallazgos clínicos y radiológicos de una paciente femenina de 69 años, con un carcinoma indiferenciado del pulmón, diagnosticado hace 2 años y medio, que comenzó con cefalea y trastornos visuales sin hipopituitarismo ni diabetes insípida. Se le realizó resonancia magnética nuclear y se le diagnosticó una lesión hipofisaria, que fue operada por vía tranesfenoidal, y se informó por anatomía patológica una metástasis del carcinoma del pulmón. CONCLUSIONES: la paciente se encuentra en estos momentos recibiendo quimioterapia, radioterapia y anticuerpo monoclonal con evolución favorable.INTRODUCTION: metastatic tumors of hypophyseal gland are infrequent. Most are silent lesions discovered accidentally in necropsy. Appearance of symptomatic metastasis is however, exceptional. DEVELOPMENT: we describe here clinical and radiological findings in a female patient aged 69, presenting with a non-differential carcinoma of lung, diagnosed two years a half ago, starting with headache and visual disorders without hypopituitarism and insipidus diabetes. We made a nuclear magnetic resonance and diagnosis was a hypophyseal lesion operated on by trans-esphenoidal route, and Pathological Anatomy Service reports a metastasis of lung carcinoma. CONCLUSIONS: patient receives chemotherapy, radiotherapy, and monoclonal antibody with a favorable evolution.

  5. Virtual labs in Leonardo da Vinci

    Directory of Open Access Journals (Sweden)

    Stanislaw Nagy

    2006-10-01

    Full Text Available This paper discusses the problem of virtual lab capabilities in the e-learning. Using combination of web conferencing and "virtual labs" capabilities, a new quality distance learning teaching is now in preparation and will be included in the course teaching to produce interactive, online simulations for the natural gas engineering studies. The activities are designed to enhance the existing curriculum and to include online assessments. A special care is devoted to the security problem between a server and a client computer. Several examples of the virtual labs related to the PVT thermodynamics, fluid flow, the natural gas well-testing, and thev gas network flow are prepared and tested. A major challenge for the 'CELGAS' system is in managing the delicate balance between the student collaboration and the isolation. Students may be encouraged to collaborate and work with each other, simulating their exploration of the lab material.

  6. LAB building a home for scientists

    CERN Document Server

    Fishman, Mark C

    2017-01-01

    Laboratories are both monasteries and space stations, redolent of the great ideas of generations past and of technologies to propel the future. Yet standard lab design has changed only little over recent years. Here Mark Fishman describes how to build labs as homes for scientists, to accommodate not just their fancy tools, but also their personalities. This richly illustrated book explores the roles of labs through history, from the alchemists of the Middle Ages to the chemists of the 19th and 20th centuries, and to the geneticists and structural biologists of today, and then turns to the special features of the laboratories Fishman helped to design in Cambridge, Shanghai, and Basel. Anyone who works in, or plans to build a lab, will enjoy this book, which will encourage them to think about how this special environment drives or impedes their important work.

  7. Jefferson Lab physics overview: Recent results

    International Nuclear Information System (INIS)

    I review highlights of the Jefferson Lab nucleon structure program. I shall emphasize recent results from experiments exploring the spin structure of the nucleon and from dedicated experiments aimed at accessing the generalized parton distributions (GPDs).

  8. Cockle Temperature Exposure Lab Experiment (2016)

    Data.gov (United States)

    U.S. Environmental Protection Agency — We carried out a lab experiment in which we exposed cockles to a range of air temperatures to simulate the physiological rigors of exposure to sunlight and air at...

  9. GeoLab Sample Handling System

    Data.gov (United States)

    National Aeronautics and Space Administration — This work builds upon the successes in developing and field testing GeoLab as part of the 2010 and 2011 Habitat Demonstration Unit (HDU) and Desert RATS activities....

  10. Photonics and Fiber Optics Processor Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Photonics and Fiber Optics Processor Lab develops, tests and evaluates high speed fiber optic network components as well as network protocols. In addition, this...

  11. Airborne Low-Frequency Sonar (ALFS) Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The ALFS lab is dedicated to support acoustic data analysis and processing software support to the AN/AQS-22 dipping sonar system. It includes stand-alone Software...

  12. Berkeley Lab Laser Accelerator (BELLA) facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Berkeley Lab Laser Accelerator (BELLA) facility (formerly LOASIS) develops advanced accelerators and radiation sources. High gradient (1-100 GV/m) laser-plasma...

  13. European labs fight back against cuts

    CERN Multimedia

    König, R

    1997-01-01

    Germany's 1997 budget contains cuts amounting to 3.7% in funding of domestic research programs and in contributions to international labs. Contributions will be cut to the European Space Agency, the European Synchrotron facility and CERN.

  14. Generator Inspection Report: Bio - Lab, Inc.

    Science.gov (United States)

    Contains report from Georgia Department of Natural Resources of July 21, 1999 inspection of the Bio - Lab Incorporated Plant 4 in Conyers, Rockdale County, Georgia, reporting that no violations were observed.

  15. Thanatology for Everyone: Developmental Labs and Workshops

    Science.gov (United States)

    O'Connell, Walter E.; And Others

    1977-01-01

    In an effort to "treat" the growing death concerns of many medical staffs, an experiential death and dying lab was created. Its evolution to meet changing needs is discussed, as well as future potential for work in this area. (Author)

  16. Are Statistics Labs Worth the Effort?--Comparison of Introductory Statistics Courses Using Different Teaching Methods

    Directory of Open Access Journals (Sweden)

    Jose H. Guardiola

    2010-01-01

    Full Text Available This paper compares the academic performance of students in three similar elementary statistics courses taught by the same instructor, but with the lab component differing among the three. One course is traditionally taught without a lab component; the second with a lab component using scenarios and an extensive use of technology, but without explicit coordination between lab and lecture; and the third using a lab component with an extensive use of technology that carefully coordinates the lab with the lecture. Extensive use of technology means, in this context, using Minitab software in the lab section, doing homework and quizzes using MyMathlab ©, and emphasizing interpretation of computer output during lectures. Initially, an online instrument based on Gardner’s multiple intelligences theory, is given to students to try to identify students’ learning styles and intelligence types as covariates. An analysis of covariance is performed in order to compare differences in achievement. In this study there is no attempt to measure difference in student performance across the different treatments. The purpose of this study is to find indications of associations among variables that support the claim that statistics labs could be associated with superior academic achievement in one of these three instructional environments. Also, this study tries to identify individual student characteristics that could be associated with superior academic performance. This study did not find evidence of any individual student characteristics that could be associated with superior achievement. The response variable was computed as percentage of correct answers for the three exams during the semester added together. The results of this study indicate a significant difference across these three different instructional methods, showing significantly higher mean scores for the response variable on students taking the lab component that was carefully coordinated with

  17. Resultaten boomkorsurvey 2013: BTS met onderzoeksvaartuigen Isis en Tridens (interview met Ingeborg de Boois)

    NARCIS (Netherlands)

    Boois, de I.J.

    2013-01-01

    Van begin augustus tot half september heeft IMARES de boomkorsurvey (BTS) uitgevoerd met de onderzoeksschepen Isis en Tridens. Op 29 maart 2014 wordt een bijeenkomst georganiseerd voor geinteresseerden, waar de resultaten van zowel de BTS als de bedrijfssurvey gepresenteerd worden. De BTS wordt

  18. PLC Support Software at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    P. Chevtsov; S. Higgins; S. Schaffner; D. Seidman

    2002-10-01

    Several Automation Direct (DirectNet) Programmable Logic Controllers (PLCs) have been integrated into the accelerator control system at Jefferson Lab. The integration is based on new software that consists of three main parts: a PLC driver with a state machine control block, a device support module, and a common serial driver. The components of new software and experience gained with the use of this software for beam dump systems at Jefferson Lab are presented.

  19. German lab wins linear collider contest

    CERN Multimedia

    Cartlidge, Edwin

    2004-01-01

    Particle physicists have chosen to base the proposed International Linear Collider on superconducting technology developed by an international collaboration centred on the DESY lab in Germany. The superconducting approach was chosen by an internatinal panel ahead of a rival technology developed at Stanford in the US and the KEK lab in Japan. The eagerly-awaited decision was announced at the International Conference on High Energy Physics in Beijing today (½ page)

  20. Evaluation of oral microbiology lab curriculum reform.

    Science.gov (United States)

    Nie, Min; Gao, Zhen Y; Wu, Xin Y; Jiang, Chen X; Du, Jia H

    2015-12-07

    According to the updated concept of oral microbiology, the School of Stomatology, Wuhan University, has carried out oral microbiology teaching reforms during the last 5 years. There was no lab curriculum before 2009 except for a theory course of oral microbiology. The school has implemented an innovative curriculum with oral medicine characteristics to strengthen understanding of knowledge, cultivate students' scientific interest and develop their potential, to cultivate the comprehensive ability of students. This study was designed to evaluate the oral microbiology lab curriculum by analyzing student performance and perceptions regarding the curriculum from 2009 to 2013. The lab curriculum adopted modalities for cooperative learning. Students collected dental plaque from each other and isolated the cariogenic bacteria with selective medium plates. Then they purified the enrichment culture medium and identified the cariogenic strains by Gram stain and biochemical tests. Both quantitative and qualitative data for 5 years were analysed in this study. Part One of the current study assessed student performance in the lab from 2009 to 2013. Part Two used qualitative means to assess students' perceptions by an open questionnaire. The 271 study students' grades on oral microbiology improved during the lab curriculum: "A" grades rose from 60.5 to 81.2 %, and "C" grades fell from 28.4 to 6.3 %. All students considered the lab curriculum to be interesting and helpful. Quantitative and qualitative data converge to suggest that the lab curriculum has strengthened students' grasp of important microbiology-related theory, cultivated their scientific interest, and developed their potential and comprehensive abilities. Our student performance and perception data support the continued use of the innovative teaching system. As an extension and complement of the theory course, the oral microbiology lab curriculum appears to improve the quality of oral medicine education and help to

  1. S'Cool LAB Summer CAMP 2017

    CERN Multimedia

    Woithe, Julia

    2017-01-01

    The S’Cool LAB Summer CAMP is an opportunity for high-school students (aged 16-19) from all around the world to spend 2 weeks exploring the fascinating world of particle physics. The 24 selected participants spend their summer at S’Cool LAB, CERN’s hands-on particle physics learning laboratory, for an epic programme of lectures and tutorials, team research projects, visits of CERN’s research installations, and social activities.

  2. Technology Roadmap: Lab-on-a-Chip

    OpenAIRE

    Pattharaporn Suntharasaj; Tugrul U Daim

    2010-01-01

    With the integration of microfluidic and MEMS technologies, biochips such as the lab-on-a-chip (LOC) devices are at the brink of revolutionizing the medical disease diagnostics industries. Remarkable advancements in the biochips industry are making products resembling Star Trek.s "tricorder" and handheld medical scanners a reality. Soon, doctors can screen for cancer at the molecular level without costly and cumbersome equipments, and discuss treatment plans based on immediate lab results. Th...

  3. Ziek en Zeer : Geelziek in Eucomis overdraagbaar met zaad

    NARCIS (Netherlands)

    Vink, P.

    2011-01-01

    In dit artikel een verslag van het onderzoek naar de risico's van overdracht van de geelziekbacterie Xanthomonas hyacinthi met Eucomiszaad. Uit het onderzoek is gebleken dat deze bacterie met het zaad kan overgaan naar een volgende teelt.

  4. MetNet Network Mission for Martian Atmospheric Investigations

    Science.gov (United States)

    Harri, A.-M.; Alexashkin, S.; Arrugeo, I.; Schmidt, W.; Vazquez, L.; Genzer, M.; Haukka, H.

    2014-07-01

    A new kind of planetary exploration mission for Mars called MetNet is being developed for martian atmospheric investigations. The eventual scope of the MetNet Mission is to deploy tens of small landers on the martian surface.

  5. Klimaatverandering en de stadsboom (interview met Jitze Kopinga)

    NARCIS (Netherlands)

    Bennink, P.; Kopinga, J.

    2010-01-01

    Bomen in de stad staan vaak op warme plaatsen met een gebrekkige waterhuishouding. Volgens het KNMI zal Nederland in de toekomst steeds vaker met hitte en droogte te maken hebben. Wat betekent dat voor onze stadsbomen?

  6. Oak Ridge National Lab., Tennessee

    International Nuclear Information System (INIS)

    Crandall, D.H.

    The available literature on electron impact ionization of ions of charge + 3 or greater is reviewed. Several easily used formulas are presented - the classical result, the Lotz formula, and a scaled Coulomb-Born prescription. The available experimental cross sections, which now include a few good quality crossed-beams measurements, are compared with the cross sections obtained from the formulae and where available with true Coulomb-Born calculations. The Lotz formula is found to be closest to the various experimental results. However, this result may be fortuitous since much of the experimental data are found to contain measurable contribution from the excitation-autoionization process not included in any of the formulae. It appears to be more important to include estimates of the excitation-autoionization contribution to ionization cross sections than to improve the models of the direct ionization process

  7. Effect of MET on formation and vigor of wheat roots

    International Nuclear Information System (INIS)

    Wang Bingkui; Jin Ziyu; Zhao Miaozhen; Zhao Yanshen

    1993-01-01

    Effect of MET on the formation and vigor of roots of wheat seedlings were studied. The results showed that 50 ∼ 200 ppm MET inhibited vertical elongation of roots, increased root, shoot ratio and enhanced the formation and vigor of roots. But MET had no effect on the dry weight of roots. The activity of peroxidase was decreased and the proportion of assimilates in roots was increased by MET treatment compared with the control

  8. Groen proceswater: zuivering brouwerijprocesafvalwater met microalgen : Resultaten onderzoek 2013

    NARCIS (Netherlands)

    Dijk, van W.; Diem, van A.; Doornbusch, P.; Grobben-Gaastra, S.A.; Kleinhout, G.; Kroon, A.; Weide, van der R.Y.

    2014-01-01

    Afgelopen jaar is de pilot met het kweken van algen met afvalwater van de brouwerijlocatie Zoeterwoude geslaagd. Dit is gedaan in een samenwerkingsverband van Heineken Nederland BV, Algae Food & Fuel en WUR-Acrres. Dit is de eerste inline pilot in de wereld waarbij met LED verlichting op 1000 L

  9. Innoveren met serious games : Wat is serious gaming?

    NARCIS (Netherlands)

    Werkhoven, P.J.

    2008-01-01

    Het begrip serious gaming is inmiddels gekaapt door vele aanbieders van wat vroeger simulatie en virtual reality technologie genoemd werd. Met die technologie kunnen we mensen laten rondlopen in virtuele gebouwen en landschappen, al dan niet met grote projectieschermen of met brillen op. Maar dat is

  10. Exclusive processes at Jefferson Lab

    Indian Academy of Sciences (India)

    probed through deeply virtual processes is therefore established. 2. Quark counting rule and oscillations. The quark counting rule predicts the energy dependence of the differential cross-section at fixed center-of-mass angles for an exclusive two-body reaction at high energy and large momentum transfer as follows:.

  11. THE STORY OF THE BC FAMILY JUSTICE INNOVATION LAB

    Directory of Open Access Journals (Sweden)

    Jane Morley

    2017-12-01

    prouvées par une séparation ou un divorce. Dans cet article, les auteures relatent les premières années d’existence du Lab. Le chemin parcouru jusqu’à maintenant est fascinant et met en lumière des objectifs ambitieux, mais il reste à savoir s’il mènera en définitive au succès. L’histoire est racontée pour que d’autres intervenants qui ont des ambitions semblables puissent s’inspirer de l’expérience et des succès du Lab et tirer des leçons de ses échecs. En raison de la nature et de la force de ces récits, l’intervenant pourra s’en inspirer pour faire ses propres expériences. De l’avis des auteures, la lecture de ces récits permet de comprendre que, pour transformer un système social aussi complexe que celui de la justice familiale de la Colombie-Britannique, il est impératif de tenir compte des différents enjeux paradoxaux et de refuser de baisser les bras, malgré les tensions créées par les vifs débats et par l’avalanche de questions épineuses auxquelles il est impossible de répondre.

  12. Bepaling van cadmium in levers en nieren van humane herkomst met behulp van atomaire-absorptiespectrofotometrie met vlamatomisatie

    NARCIS (Netherlands)

    Wubs KL; Mulder W; de Groot G

    1988-01-01

    In dit rapport wordt een methode beschreven voor de bepaling van cadmium in levers en nieren van humane herkomst met behulp van atomaire absorptiespectrofotometrie en vlamatomisatie. De weefselmonsters worden ontleed met een enzymatische methode onder fysiologische condities, gevolgd door

  13. Phase I Trial of Anti-MET Monoclonal Antibody in MET-Overexpressed Refractory Cancer.

    Science.gov (United States)

    Lee, Jeeyun; Kim, Seung Tae; Park, Sungju; Lee, Sujin; Park, Se Hoon; Park, Joon Oh; Lim, Ho Yeong; Ahn, Hongmo; Bok, Haesook; Kim, Kyoung-Mee; Ahn, Myung Ju; Kang, Won Ki; Park, Young Suk

    2018-01-31

    Samsung Advance Institute of Technology-301 (SAIT301) is a human immunoglobulin G2 antibody that can specifically target mesenchymal epithelial transition factor (c-MET). This novel antibody has higher priority over hepatocyte growth factors when binding to the Sema domain of c-MET and accelerates the internalization and degradation of c-MET, proving its powerful antitumor activities in intra- as well as extracellular areas. SAIT301 was administered intravenously once every 3 weeks in c-MET overexpressed solid tumor patients, focusing on metastatic colorectal cancer (CRC) according to common clinical phase I criteria. Dose escalation was performed according to a modified Fibonacci design, following the conventional 3+3 design. The purpose of this phase I study was to assess the safety profile, to establish the recommended dose for clinical phase II studies and to assess potential anticancer activity of the compound. Sixteen patients with a median age of 56 (range, 39-69) years were enrolled in the study. The most common adverse events were decreased appetite (50.0%), hypophosphatemia, fatigue and dizziness (25.0%, respectively), and diarrhea, blood alkaline phosphatase increased and dyspnea (18.8%, respectively). For tumor response, no patients achieved complete response. One (9.1%) CRC patient had a partial response in the 1.23 mg/kg group, 4 (36.4%) patients achieved stable disease (2 in the 0.41 mg/kg group, 2 in the 1.23 mg/kg group, 0 in the 3.69 mg/kg group, and 1 in the 8.61 mg/kg group). Because of the increase in dose-limiting toxicities (DLTs) at 8.61 mg/kg, the 3.69 mg/kg dose was considered the maximum tolerated dose and selected for further assessment in phase II. We successfully completed a phase I trial with MET antibody in a MET-overexpressed patient population focusing on CRC, and found that the DLTs were alkaline phosphatase elevation or hypophosphatemia. The recommended dose of SAIT301 for phase II is the dose of 3.69 mg/kg. Copyright © 2018

  14. 3D RoboMET Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Madison, Jonathan D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Susan, Donald F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kilgo, Alice C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    The goal of this project is to generate 3D microstructural data by destructive and non-destructive means and provide accompanying characterization and quantitative analysis of such data. This work is a continuing part of a larger effort to relate material performance variability to microstructural variability. That larger effort is called “Predicting Performance Margins” or PPM. In conjunction with that overarching initiative, the RoboMET.3D™ is a specific asset of Center 1800 and is an automated serialsectioning system for destructive analysis of microstructure, which is called upon to provide direct customer support to 1800 and non-1800 customers. To that end, data collection, 3d reconstruction and analysis of typical and atypical microstructures have been pursued for the purposes of qualitative and quantitative characterization with a goal toward linking microstructural defects and/or microstructural features with mechanical response. Material systems examined in FY15 include precipitation hardened 17-4 steel, laser-welds of 304L stainless steel, thermal spray coatings of 304L and geological samples of sandstone.

  15. Responses to the multitargeted MET/ALK/ROS1 inhibitor crizotinib and co-occurring mutations in lung adenocarcinomas with MET amplification or MET exon 14 skipping mutation.

    Science.gov (United States)

    Jorge, Susan E; Schulman, Sol; Freed, Jason A; VanderLaan, Paul A; Rangachari, Deepa; Kobayashi, Susumu S; Huberman, Mark S; Costa, Daniel B

    2015-12-01

    Genomic aberrations involving ALK, ROS1 and MET can be driver oncogenes in lung adenocarcinomas. Identification of tyrosine kinase inhibitors (TKIs) with activity against these tumors and of preclinical systems to model response are warranted. We analyzed cases with lung adenocarcinomas for representative genomic aberrations, evaluated the response to the multitargeted MET/ALK/ROS1 crizotinib TKI in cases with MET aberrations and profiled lung cancer cell lines with the aforementioned genomic changes. Lung cancer cell lines with ALK rearrangement, ROS1 rearrangement or MET amplification had expected in vitro responses to crizotinib and the ALK/ROS1 TKI ceritinib. However, a commercially-available cell line with MET exon 14 skipping mutation and co-occurring PIK3CA-p.Glu545Lys mutation did not respond to crizotinib; suggesting the latter abrogated response. 10% of MET exon 14 skipping mutation co-occurred with PIK3CA mutation in the TCGA cohort. Putative crizotinib-responsive somatic mutations (ALK rearrangements, ROS1 rearrangements, high level MET amplification or MET exon 14 skipping mutations) were present in 10% of lung adenocarcinomas analyzed at our service and in 9.5% of the TCGA lung adenocarcinoma database. One patient each whose advanced tumors harbored high level MET amplification with wild-type PIK3CA or MET exon 14 skipping mutation with PIK3CA-p.Glu542Lys had significant responses to crizotinib; suggesting that PIK3CA co-mutation did not affect clinical response. Approximately 10% of lung adenocarcinomas harbor aberrations that are targetable using the approved multitargeted TKI crizotinib. MET exon 14 skipping mutation predicts for response to MET TKIs in human lung adenocarcinomas but co-occurrence of PIK3CA mutation needs to be better evaluated as a modifier of response to TKI therapy. MET TKIs should not be omitted from MET exon 14 skipping mutated tumors until further preclinical and clinical data can confirm or refute mechanisms of primary or

  16. 21 CFR 111.73 - What is your responsibility for determining whether established specifications are met?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What is your responsibility for determining whether established specifications are met? 111.73 Section 111.73 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD...

  17. 21 CFR 111.77 - What must you do if established specifications are not met?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What must you do if established specifications are not met? 111.77 Section 111.77 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN...

  18. Assessing Usage and Maximizing Finance Lab Impact: A Case Exploration

    Science.gov (United States)

    Noguera, Magdy; Budden, Michael Craig; Silva, Alberto

    2011-01-01

    This paper reports the results of a survey conducted to assess students' usage and perceptions of a finance lab. Finance labs differ from simple computer labs as they typically contain data boards, streaming market quotes, terminals and software that allow for real-time financial analyses. Despite the fact that such labs represent significant and…

  19. An under-met and over-met expectations model of employee reactions to merit raises.

    Science.gov (United States)

    Schaubroeck, John; Shaw, Jason D; Duffy, Michelle K; Mitra, Atul

    2008-03-01

    The authors developed a model of how raise expectations influence the relationship between merit pay raises and employee reactions and tested it using a sample of hospital employees. Pay-for-performance (PFP) perceptions were consistently related to personal reactions (e.g., pay raise happiness, pay-level satisfaction, and turnover intentions). Merit pay raises were strongly related to reactions only among employees with high raise expectations and high PFP perceptions. The interactive effects of under-met/over-met expectations and PFP perceptions were mediated by the extent to which participants saw the raise as generous and they were happy with the raises they received. The authors discuss the implications of these findings for expectation-fulfillment theories, merit pay research, and the administration of incentives. Copyright 2008 APA

  20. The Design:Lab as platform in participatory design research

    DEFF Research Database (Denmark)

    Binder, Thomas; Brandt, Eva

    2008-01-01

    The notion of laboratory or simply 'lab' has become popular in recent years in areas outside science and technology development. Learning Labs, Innovation Labs, Usability Labs, Media and Communication Labs and even Art Labs designate institutions or fora dedicated to change and experimentation....... Influenced by these currents we use the expression 'Design:Lab' as a shorthand description of open collaborations between many stakeholders sharing a mutual interest in design research in a particular field. Many have reacted to the term 'laboratory' or 'lab' as foreign and awkward to design, and we as well...... as others have frequently used other metaphors like workshop, studio or atelier in design research. In this article we will argue that the laboratory metaphor is particularly suitable and useful for the design:lab, and we will give examples of how we have worked with the design:lab as a platform...

  1. MACMA: a Virtual Lab for Plate Tectonics

    Science.gov (United States)

    Grigne, C.; Combes, M.; Tisseau, C.

    2013-12-01

    MACMA (Multi-Agent Convective MAntle) is a tool developed to simulate evolutive plate tectonics and mantle convection in a 2-D cylindrical geometry (Combes et al., 2012). The model relies mainly on a force balance to compute the velocity of each plate, and on empirical rules to determine how plate boundaries move and evolve. It includes first-order features of plate tectonics: (a) all plates on Earth do not have the same size, (b) subduction zones are asymmetric, (c) plates driven by subducting slabs and upper plates do not exhibit the same velocities, and (d) plate boundaries are mobile, can collide, merge and disappear, and new plate boundaries can be created. The MACMA interface was designed to be user-friendly and a simple use of the simulator can be achieved without any prerequisite knowledge in fluid dynamics, mantle rheology, nor in numerical methods. As a preliminary study, the simulator was used by a few students from bachelor's degree to master's degree levels. An initial configuration for plate tectonics has to be created before starting a simulation: the number and types of plate boundaries (ridge, subduction, passive margins) has to be defined and seafloor ages must be given. A simple but interesting exercise consists in letting students build such an initial configuration: they must analyze a map of tectonic plates, choose a 2-D section and examine carefully a map of seafloor ages. Students mentioned that the exercise made them realize that the 3-D spherical structure of plate tectonics does not translate directly in a simple 2-D section, as opposed to what is usually shown in books. Physical parameters: e.g. mantle viscosity, number of layers to consider in the mantle (upper and lower mantle, possible asthenosphere), initial time and mantle temperature, have to be chosen, and students can use this virtual lab to see how different scenarios emerge when parameters are varied. Very importantly, the direct visualization of the mobility of plate

  2. eLabEL: Technology-supported living labs in primary care

    NARCIS (Netherlands)

    Vermeulen, Joan; Huygens, Martine; de Witte, Luc P.; Oude Nijeweme-d'Hollosy, Wendeline; Swinkels, Ilse; van Velsen, Lex Stefan; Jansen, Yvonne

    2015-01-01

    Telecare technologies and eHealth applications can support patients and care professionals. However, these technologies are currently not being implemented in primary care. The eLabEL project aims to contribute to a solution for this problem by establishing Living Labs in which patients, healthcare

  3. Progress in switching technology for METS systems

    International Nuclear Information System (INIS)

    Honig, E.M.; Swannack, C.E.; Warren, R.W.; Whitaker, D.H.

    1977-01-01

    Three distinct sets of switching requirements have emerged from design optimization studies of large superconducting magnetic energy storage systems, such as the METS system to power the adiabatic plasma compression field in the proposed theta-pinch SFTR. Extremely low joule loss cryogenic disconnects are required between storage coils in the liquid helium environment to allow charging the coils in series over a prolonged time, then to isolate the coils for parallel fast discharging into the load. Another switch must break the current in the series charging loop and absorb the energy from the stray inductance. This action will allow the subsequent opening of the cryogenic disconnects under near zero current condition. The current now has been transferred to the many paralleled circuits, each containing a high current, high voltage interrupter. The opening and arc commutation of the interrupter starts the energy transfer into the load. The primary activities associated with cryogenic disconnect have been testing and development of contact materials, configurations, and closing forces for carrying 26 kA with a resistance less than 40 nΩ, and development of an actuating system that is both reliable and fast acting in a liquid helium environment. The charging loop switch will include a continuous duty switch and a vacuum interrupter. The continuous duty switch resistance can be an order of magnitude larger than that of the cryogenic disconnect because it does not present a refrigeration load. The HVDC interrupter must break 26 kA and withstand 60 kV during the energy transfer time of 700 μs. Testing in progress already has shown successful interruption using single vacuum interrupters up to 31 kA and 66 kV

  4. Measurements of HONO during BAQS-Met

    Directory of Open Access Journals (Sweden)

    J. J. B. Wentzell

    2010-12-01

    Full Text Available Measurements of nitrous acid (HONO were performed as part of the 2007 Border Air Quality and Meteorology Study (BAQS-Met at the Harrow, Ontario, Canada supersite between 20 June and 10 July 2007. Nitrous acid is an important precursor of the hydroxyl radical and understanding its chemistry is important to understanding daytime oxidation chemistry. The HONO measurements were made using a custom built Long Path Absorption Photometer (LOPAP. The goal of this work was to shed light on sources of daytime HONO in the border region. During the course of the campaign HONO mixing ratios consistently exceeded expected daytime values by more than a factor of 6. Mean daytime mixing ratios of 61 pptv were observed. While HONO decay began at sunrise, minimum HONO values were measured during the late afternoon. There was little difference between the daytime (mean = 1.5% and night-time (mean = 1.7% ratios of HONO/NO2, thus there was a very strong daytime source of HONO which is consistent with other recent studies. Correlations of daytime HONO production with a variety of chemical and meteorological parameters indicate that production is dependent on UV radiation, NO2 and water vapour but is not consistent with a simple gas phase process. Apparent rate constants for the production of HONO from photolyticaly excited NO2 and water vapour vary from 2.8–7.8×10−13 cm3 molec−1 s−1, during the campaign. These results appear to be consistent with the heterogeneous conversion of NO2 enhanced by photo-excitation.

  5. Are Virtual Labs as Effective as Hands-on Labs for Undergraduate Physics? A Comparative Study at Two Major Universities

    Science.gov (United States)

    Darrah, Marjorie; Humbert, Roxann; Finstein, Jeanne; Simon, Marllin; Hopkins, John

    2014-01-01

    Most physics professors would agree that the lab experiences students have in introductory physics are central to the learning of the concepts in the course. It is also true that these physics labs require time and money for upkeep, not to mention the hours spent setting up and taking down labs. Virtual physics lab experiences can provide an…

  6. Feasibility online survey to estimate physical activity level among the students studying professional courses: a cross-sectional online survey.

    Science.gov (United States)

    Sudha, Bhumika; Samuel, Asir John; Narkeesh, Kanimozhi

    2018-02-01

    The aim of the study was to estimate the physical activity (PA) level among the professional college students in North India. One hundred three professional college students in the age group of 18-25 years were recruited by simple random sampling for this cross-sectional online survey. The survey was advertised on the social networking sites (Facebook, WhatsApp) through a link www.surveymonkey.com/r/MG-588BY. A Short Form of International Physical Activity Questionnaire was used for this survey study. The questionnaire included total 8 questions on the basis of previous 7 days. The questionnaire consists of 3 main categories which were vigorous, moderate and high PA. Time spent in each activity level was multiplied with the metabolic equivalent of task (MET), which has previously set to 8.0 for vigorous activity, 4.0 for moderate activity, 3.3 for walking, and 1.5 for sitting. By multiplying MET with number of days and minutes performed weekly, amount of each activity level was calculated and measured as MET-min/wk. Further by adding MET minutes for each activity level, total MET-min/wk was calculated. Total number of 100 students participated in this study, and it was shown that all professional course students show different levels in PA. The total PA level among professional college students, which includes, physiotherapy, dental, medical, nursing, lab technician, pharmacy, management, law, engineering, were 434.4 (0-7,866), 170.3 (0-1,129), 87.7 (0-445), 102.8 (0-180), 469 (0-1,164), 0 (0-0), 645 (0-1,836), 337 (0-1,890), 396 (0-968) MET-min/wk respectively. PA levels among professional college students in North India have been established.

  7. Are Remote Labs Worth the Cost? Insights From a Study of Student Perceptions of Remote Labs

    Directory of Open Access Journals (Sweden)

    David Uttal

    2011-05-01

    Full Text Available Remote online laboratories enable students to conduct scientific investigations using real experimental equipment. However, scaling up remote labs may require significant costs in purchasing and maintaining expensive equipment compared to scaling simulated labs. While these costs are a consequence of using physical equipment, we argue that there are unique educational advantages to remote labs. This paper presents the results of a preliminary study of student perceptions of a remote lab in comparison to an identical lab experience with simulated data. The findings reveal several intriguing themes that highlight the pedagogical value of remote laboratories. In addition, we provide recommendations for the design and pedagogy of online laboratory experiences based on our findings.

  8. Environment monitoring using LabVIEW

    International Nuclear Information System (INIS)

    Hawtree, J.

    1995-01-01

    A system has been developed for electronically recording and monitoring temperature, humidity, and other environmental variables at the Silicon Detector Facility located in Lab D. The data is collected by LabVIEW software, which runs in the background on an Apple Macintosh. The software is completely portable between Macintosh, MS Windows, and Sun platforms. The hardware includes a Macintosh with 8 MB of RAM; an external ADC-1 analog-to-digital converter that uses a serial port; LabVIEW software; temperature sensors; humidity sensors; and other voltage/current sensing devices. ADC values are converted to ASCII strings and entered into files which are read over Ethernet. Advantages include automatic logging, automatic recovery after power interruptions, and the availability of stand-alone applications for other locations with inexpensive software and hardware

  9. A Moodle extension to book online labs

    Directory of Open Access Journals (Sweden)

    Antonio C. Cardoso

    2005-11-01

    Full Text Available The social constructivist philosophy of Moodle makes it an excellent choice to deliver e-learning contents that require collaborative activities, such as those that are associated with online labs. In the case of online labs that enable web access to real devices (remote workbenches, access time should be reserved beforehand. A booking tool will avoid access conflicts and at the same time will help the students to organise their time and activities. This paper presents a Moodle extension that was developed within the Leonardo da Vinci MARVEL project, with the objective of meeting this requirement. The booking tool presented enables resource sharing in general and may be used to organise access to any type of scarce resources, such as to online labs and to the videoconferencing rooms that are needed to support collaborative activities.

  10. Collaborative Creation of a Lab Rubric

    Directory of Open Access Journals (Sweden)

    Carrie Miller-DeBoer

    2011-03-01

    Full Text Available While there are a number of tested rubrics in circulation, our task was to intervene in a particular situation: the lead professor was concerned because her graduate teaching assistants held negative views about student performance on the lab reports. GTAs found poor products frustrating, and admitted that their grading was thus superficial and provided no feedback to students. Specifically, GTAs did not feel equipped to evaluate writing and, as a result, simply graded on steps completed in the lab process.We have a rubric now for an Introduction to Zoology lab that could be submitted here as a pretty darn good rubric for other instructors to use. But the intent of our “Tips and Tools” is to describe the actual creation of the rubric. We believe the active “real time” development of the rubric carried as much or more value than the finished product.

  11. LabVIEW Real-Time

    CERN Multimedia

    CERN. Geneva; Flockhart, Ronald Bruce; Seppey, P

    2003-01-01

    With LabVIEW Real-Time, you can choose from a variety of RT Series hardware. Add a real-time data acquisition component into a larger measurement and automation system or create a single stand-alone real-time solution with data acquisition, signal conditioning, motion control, RS-232, GPIB instrumentation, and Ethernet connectivity. With the various hardware options, you can create a system to meet your precise needs today, while the modularity of the system means you can add to the solution as your system requirements grow. If you are interested in Reliable and Deterministic systems for Measurement and Automation, you will profit from this seminar. Agenda: Real-Time Overview LabVIEW RT Hardware Platforms - Linux on PXI Programming with LabVIEW RT Real-Time Operating Systems concepts Timing Applications Data Transfer

  12. Digital Design with KP-Lab

    Directory of Open Access Journals (Sweden)

    D. Ponta

    2007-08-01

    Full Text Available KP-Lab is an EU Integrated Project envisioning a learning system that facilitates innovative practices of sharing, creating and working with knowledge in education and workplaces. The project exploits a novel pedagogical view, the knowledge-creation metaphor of learning. According to such “trialogical” approach, cognition arises through collaborative work in systematically developing shared “knowledge artefacts”, such as concepts, plans, material products, or social practices. The paper presents the plan of a pilot course to test the KP-Lab methodologies and tools in the field of Digital Design.

  13. [Semiotic Studies Lab for Patient Care Interactions].

    Science.gov (United States)

    Nunes, Dulce Maria; Portella, Jean Cristtus; Bianchi e Silva, Laura

    2011-12-01

    The aim of this experience report is to present the Semiotic Studies Lab for Patient Care Interactions (Laboratório de Estudos Semióticos nas Interações de Cuidado - LESIC). The lab was set up at the Nursing School of the Federal University of Rio Grande do Sul (UFRGS), Brazil in 2010. It has the purpose of providing didactic and pedagogical updates, based on the Theory developed by the Paris School of Semiotics, that enable the increase of knowledge and interactive/observational skills regarding the nature and mastery of human care.

  14. Research progress in c-Met and hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    WANG Changqing

    2015-06-01

    Full Text Available c-Met plays a pivotal role in the development and progression of hepatocellular carcinoma (HCC, which can lead to proliferation, survival, cytoskeleton reorganization, separation and diffusion, and angiogenesis of tumor cells. Moreover, c-Met is an important prognostic factor for HCC. In HCC, c-Met acts as an activator of a series of signaling pathways, including PI3K/AKT/mTOR, ERK/MAPK, and Rac-Pak. In recent years, it has been reported that small-molecule kinase inhibitors can abolish phosphorylation at the intracellular carboxyl terminal of c-Met, and then inhibit the recruitment of signal convertors and downstream signaling pathways, which finally achieve anti-tumor activities. Based on the carcinogenic activity of c-Met in HCC, this paper points out that selective inhibitors of c-Met hold promise for targeted therapies for HCC.

  15. Effective implementation of novel MET pharmacodynamic assays in translational studies.

    Science.gov (United States)

    Srivastava, Apurva K; Navas, Tony; Herrick, William G; Hollingshead, Melinda G; Bottaro, Donald P; Doroshow, James H; Parchment, Ralph E

    2017-01-01

    MET tyrosine kinase (TK) dysregulation is significantly implicated in many types of cancer. Despite over 20 years of drug development to target MET in cancers, a pure anti-MET therapeutic has not yet received market approval. The failure of two recently concluded phase III trials point to a major weakness in biomarker strategies to identify patients who will benefit most from MET therapies. The capability to interrogate oncogenic mutations in MET via circulating tumor DNA (ctDNA) provides an important advancement in identification and stratification of patients for MET therapy. However, a wide range in type and frequency of these mutations suggest there is a need to carefully link these mutations to MET dysregulation, at least in proof-of-concept studies. In this review, we elaborate how we can utilize recently developed and validated pharmacodynamic biomarkers of MET not only to show target engagement, but more importantly to quantitatively measure MET dysregulation in tumor tissues. The MET assay endpoints provide evidence of both canonical and non-canonical MET signaling, can be used as "effect markers" to define biologically effective doses (BEDs) for molecularly targeted drugs, confirm mechanism-of-action in testing combination of drugs, and establish whether a diagnostic test is reporting MET dysregulation. We have established standard operating procedures for tumor biopsy collections to control pre-analytical variables that have produced valid results in proof-of-concept studies. The reagents and procedures are made available to the research community for potential implementation on multiple platforms such as ELISA, quantitative immunofluorescence assay (qIFA), and immuno-MRM assays.

  16. De kracht van sport: Sporten voor kinderen met gedragsproblemen

    OpenAIRE

    Pruim, Arjan; Mombarg, Remo

    2016-01-01

    In deze presentatie staat centraal hoe het bewegingsonderwijs kan worden aangepast op kinderen met een beperking. We weten dat kinderen met een beperking duidelijk minder vaak sporten en/of lid zijn van een vereniging. Desondanks heeft sport ook voor deze kinderen een betekenis. Zo kan sport een middel zijn om hyperactiviteit, emotionele problemen en externaliserende gedragsproblemen te verminderen. Een voorbeeld van een nationaal sportstimuleringsproject gericht op kinderen met een beperking...

  17. Targeting MET Amplification as a New Oncogenic Driver.

    Science.gov (United States)

    Kawakami, Hisato; Okamoto, Isamu; Okamoto, Wataru; Tanizaki, Junko; Nakagawa, Kazuhiko; Nishio, Kazuto

    2014-07-22

    Certain genetically defined cancers are dependent on a single overactive oncogene for their proliferation and survival, a phenomenon known as "oncogene addiction". A new generation of drugs that selectively target such "driver oncogenes" manifests a clinical efficacy greater than that of conventional chemotherapy in appropriate genetically defined patients. MET is a proto-oncogene that encodes a receptor tyrosine kinase, and aberrant activation of MET signaling occurs in a subset of advanced cancers as result of various genetic alterations including gene amplification, polysomy, and gene mutation. Our preclinical studies have shown that inhibition of MET signaling either with the small-molecule MET inhibitor crizotinib or by RNA interference targeted to MET mRNA resulted in marked antitumor effects in cancer cell lines with MET amplification both in vitro and in vivo. Furthermore, patients with non-small cell lung cancer or gastric cancer positive for MET amplification have shown a pronounced clinical response to crizotinib. Accumulating preclinical and clinical evidence thus suggests that MET amplification is an "oncogenic driver" and therefore a valid target for treatment. However, the prevalence of MET amplification has not been fully determined, possibly in part because of the difficulty in evaluating gene amplification. In this review, we provide a rationale for targeting this genetic alteration in cancer therapy.

  18. Targeting MET Amplification as a New Oncogenic Driver

    Directory of Open Access Journals (Sweden)

    Hisato Kawakami

    2014-07-01

    Full Text Available Certain genetically defined cancers are dependent on a single overactive oncogene for their proliferation and survival, a phenomenon known as “oncogene addiction”. A new generation of drugs that selectively target such “driver oncogenes” manifests a clinical efficacy greater than that of conventional chemotherapy in appropriate genetically defined patients. MET is a proto-oncogene that encodes a receptor tyrosine kinase, and aberrant activation of MET signaling occurs in a subset of advanced cancers as result of various genetic alterations including gene amplification, polysomy, and gene mutation. Our preclinical studies have shown that inhibition of MET signaling either with the small-molecule MET inhibitor crizotinib or by RNA interference targeted to MET mRNA resulted in marked antitumor effects in cancer cell lines with MET amplification both in vitro and in vivo. Furthermore, patients with non-small cell lung cancer or gastric cancer positive for MET amplification have shown a pronounced clinical response to crizotinib. Accumulating preclinical and clinical evidence thus suggests that MET amplification is an “oncogenic driver” and therefore a valid target for treatment. However, the prevalence of MET amplification has not been fully determined, possibly in part because of the difficulty in evaluating gene amplification. In this review, we provide a rationale for targeting this genetic alteration in cancer therapy.

  19. Targeting MET Amplification as a New Oncogenic Driver

    International Nuclear Information System (INIS)

    Kawakami, Hisato; Okamoto, Isamu; Okamoto, Wataru; Tanizaki, Junko; Nakagawa, Kazuhiko; Nishio, Kazuto

    2014-01-01

    Certain genetically defined cancers are dependent on a single overactive oncogene for their proliferation and survival, a phenomenon known as “oncogene addiction”. A new generation of drugs that selectively target such “driver oncogenes” manifests a clinical efficacy greater than that of conventional chemotherapy in appropriate genetically defined patients. MET is a proto-oncogene that encodes a receptor tyrosine kinase, and aberrant activation of MET signaling occurs in a subset of advanced cancers as result of various genetic alterations including gene amplification, polysomy, and gene mutation. Our preclinical studies have shown that inhibition of MET signaling either with the small-molecule MET inhibitor crizotinib or by RNA interference targeted to MET mRNA resulted in marked antitumor effects in cancer cell lines with MET amplification both in vitro and in vivo. Furthermore, patients with non-small cell lung cancer or gastric cancer positive for MET amplification have shown a pronounced clinical response to crizotinib. Accumulating preclinical and clinical evidence thus suggests that MET amplification is an “oncogenic driver” and therefore a valid target for treatment. However, the prevalence of MET amplification has not been fully determined, possibly in part because of the difficulty in evaluating gene amplification. In this review, we provide a rationale for targeting this genetic alteration in cancer therapy

  20. Targeting MET Amplification as a New Oncogenic Driver

    Energy Technology Data Exchange (ETDEWEB)

    Kawakami, Hisato [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Okamoto, Isamu, E-mail: okamotoi@kokyu.med.kyushu-u.ac.jp [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Center for Clinical and Translational Research, Kyushu University Hospital, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582 (Japan); Okamoto, Wataru [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Division of Transrlational Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577 (Japan); Tanizaki, Junko [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, HIM223, 450 Brookline Avenue, Boston, MA 02215 (United States); Nakagawa, Kazuhiko [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Nishio, Kazuto [Department of Genome Biology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan)

    2014-07-22

    Certain genetically defined cancers are dependent on a single overactive oncogene for their proliferation and survival, a phenomenon known as “oncogene addiction”. A new generation of drugs that selectively target such “driver oncogenes” manifests a clinical efficacy greater than that of conventional chemotherapy in appropriate genetically defined patients. MET is a proto-oncogene that encodes a receptor tyrosine kinase, and aberrant activation of MET signaling occurs in a subset of advanced cancers as result of various genetic alterations including gene amplification, polysomy, and gene mutation. Our preclinical studies have shown that inhibition of MET signaling either with the small-molecule MET inhibitor crizotinib or by RNA interference targeted to MET mRNA resulted in marked antitumor effects in cancer cell lines with MET amplification both in vitro and in vivo. Furthermore, patients with non-small cell lung cancer or gastric cancer positive for MET amplification have shown a pronounced clinical response to crizotinib. Accumulating preclinical and clinical evidence thus suggests that MET amplification is an “oncogenic driver” and therefore a valid target for treatment. However, the prevalence of MET amplification has not been fully determined, possibly in part because of the difficulty in evaluating gene amplification. In this review, we provide a rationale for targeting this genetic alteration in cancer therapy.

  1. Mars MetNet Mission Pressure and Humidity Devices

    Science.gov (United States)

    Haukka, H.; Harri, A.-M.; Schmidt, W.; Genzer, M.; Polkko, J.; Kemppinen, O.; Leinonen, J.

    2012-09-01

    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). MetBaro and MetHumi are part of the scientific payload of the MNL. Main scientific goal of both devices is to measure the meteorological phenomena (pressure and humidity) of the Martian atmosphere and complement the previous Mars mission atmospheric measurements (Viking and Phoenix) for better understanding of the Martian atmospheric conditions.

  2. The Portuguese Contribution for lab2go - pt.lab2go

    Directory of Open Access Journals (Sweden)

    Maria Teresa Restivo

    2013-01-01

    Full Text Available Online experimentation provides innovative and valuable tools for use in academy, in high schools, in industry and in medical areas. It has also become a precious tool for educational and training purposes in any of those areas. Looking at online experimentation as a pure distance learning tool it represents a very efficient way of sharing hands-on capabilities, for example with developing countries. In Portugal a new consortium of online experimentation was created for fostering the national potential, using the Portuguese version of lab2go web platform, pt.lab2go. The authors pretend to demonstrate some of capabilities of the consortium in sharing online labs.

  3. Electronics Lab Instructors' Approaches to Troubleshooting Instruction

    Science.gov (United States)

    Dounas-Frazer, Dimitri R.; Lewandowski, H. J.

    2017-01-01

    In this exploratory qualitative study, we describe instructors' self-reported practices for teaching and assessing students' ability to troubleshoot in electronics lab courses. We collected audio data from interviews with 20 electronics instructors from 18 institutions that varied by size, selectivity, and other factors. In addition to describing…

  4. Encouraging Creativity in the Science Lab

    Science.gov (United States)

    Eyster, Linda

    2010-01-01

    Although science is a creative endeavor (NRC 1996, p. 46), many students think they are not encouraged--or even allowed--to be creative in the laboratory. When students think there is only one correct way to do a lab, their creativity is inhibited. Park and Seung (2008) argue for the importance of creativity in science classrooms and for the…

  5. FameLab - Swiss Semi Finals

    CERN Multimedia

    Corinne Pralavorio

    2012-01-01

    Twenty-two young scientists participated in the FameLab semi-final at CERN's Globe of Science and Innovation on 4 February, supported by a large audience and by more than 100 fans following via webcast. A panel of judges chose Lemmer and four other candidates to join five other semi-finalists at the national finals in Zurich on 30 March.

  6. mQoL smart lab

    DEFF Research Database (Denmark)

    De Masi, Alexandre; Ciman, Matteo; Gustarini, Mattia

    2016-01-01

    As a base for hypothesis formulation and testing, accurate, timely and reproducible data collection is a challenge for all researchers. Data collection is especially challenging in uncontrolled environments, outside of the lab and when it involves many collaborating disciplines, where the data mu...

  7. Information at a Cost: A Lab Experiment

    NARCIS (Netherlands)

    P. Robalo (Pedro); R.S. Sayag (Rei)

    2012-01-01

    textabstractThe supposed irrelevance of historical costs for rational decision making has been the subject of much interest in the economic literature. In this paper we explore whether individual decision making under risk is affected by the cost of the supplied information. Outside of the lab, it

  8. Nonverbal Communication and Writing Lab Tutorials.

    Science.gov (United States)

    Claywell, Gina

    Writing labs should utilize the knowledge gained from a variety of fields to enhance further their programs, particularly with regard to the study of nonverbal communication. Regardless of the sincerity and importance of the tutor's suggestions, nonverbal messages often are sent to the student which undermine the session. Various channels of…

  9. Design Lab 2005 : pilk steriilsesse elektrotulevikku

    Index Scriptorium Estoniae

    2005-01-01

    Design Lab kutsub disainereid ja üliõpilasi üle terve maailma tegelema kaugemale tulevikku suunatud visioonidega. 2005. a. konkurss otsis nutikaid ja säästlikke lahendusi, mis võiksid 2020. a. kodudes olla juba juurdunud, keskenduti kodutehnikale

  10. Carleton to oversee $40 million lab grant

    CERN Multimedia

    Singer, Zev

    2003-01-01

    "Carleton University got a major gift yesterday, as the federal government announced the university will oversee a $40-million grant to run the world's deepest underground lab at the Sudbury Neutrino Observatory. Five other universities are partners in the project" (1/2 page).

  11. Displacing Media: LCD LAB Artistic Residency

    Directory of Open Access Journals (Sweden)

    Filipe Pais

    2012-12-01

    Full Text Available This review refers to an artistic residency which took place at LCD LAB -  CAAA at Guimarães, in March, exploring a strategy for media art called Media Displacement. The text introduces the strategy very briefly and describes the residency's organization, structure, processses and the results produced.

  12. Surfactant Adsorption: A Revised Physical Chemistry Lab

    Science.gov (United States)

    Bresler, Marc R.; Hagen, John P.

    2008-01-01

    Many physical chemistry lab courses include an experiment in which students measure surface tension as a function of surfactant concentration. In the traditional experiment, the data are fit to the Gibbs isotherm to determine the molar area for the surfactant, and the critical micelle concentration is used to calculate the Gibbs energy of micelle…

  13. A Hardware Lab Anywhere At Any Time

    Directory of Open Access Journals (Sweden)

    Tobias Schubert

    2004-12-01

    Full Text Available Scientific technical courses are an important component in any student's education. These courses are usually characterised by the fact that the students execute experiments in special laboratories. This leads to extremely high costs and a reduction in the maximum number of possible participants. From this traditional point of view, it doesn't seem possible to realise the concepts of a Virtual University in the context of sophisticated technical courses since the students must be "on the spot". In this paper we introduce the so-called Mobile Hardware Lab which makes student participation possible at any time and from any place. This lab nevertheless transfers a feeling of being present in a laboratory. This is accomplished with a special Learning Management System in combination with hardware components which correspond to a fully equipped laboratory workstation that are lent out to the students for the duration of the lab. The experiments are performed and solved at home, then handed in electronically. Judging and marking are also both performed electronically. Since 2003 the Mobile Hardware Lab is now offered in a completely web based form.

  14. Lab-on a-Chip

    Science.gov (United States)

    2003-01-01

    Helen Cole, the project manager for the Lab-on-a-Chip Applications Development program, and Lisa Monaco, the project scientist for the program, insert a lab on a chip into the Caliper 42 which is specialized equipment that controls processes on commercial chips to support development of lab-on-a-chip applications. The system has special microscopes and imaging systems, so scientists can process and study different types of fluid, chemical, and medical tests conducted on chips. For example, researchers have examined fluorescent bacteria as it flows through the chips' fluid channels or microfluidic capillaries. Researchers at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama, have been studying how the lab-on-a-chip technology can be used for microbial detection, water quality monitoring, and detecting biosignatures of past or present life on Mars. The Marshall Center team is also collaborating with scientists at other NASA centers and at universities to develop custom chip designs for not only space applications, but for many Earth applications, such as for detecting deadly microbes in heating and air systems. (NASA/MSFC/D.Stoffer)

  15. LabVIEW A Developer's Guide to Real World Integration

    CERN Document Server

    Fairweather, Ian

    2011-01-01

    LabVIEW(t) has become one of the preeminent platforms for the development of data acquisition and data analysis programs. LabVIEW(t): A Developer's Guide to Real World Integration explains how to integrate LabVIEW into real-life applications. Written by experienced LabVIEW developers and engineers, the book describes how LabVIEW has been pivotal in solving real-world challenges. Each chapter is self-contained and demonstrates the power and simplicity of LabVIEW in various applications, from image processing to solar tracking systems. Many of the chapters explore how exciting new technologies c

  16. Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks

    DEFF Research Database (Denmark)

    Dodds, Chris M; Henson, Richard N; Suckling, John

    2013-01-01

    It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation...... of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including an investigation of the effect of met allele load on memory related activation in the medial temporal lobe....... In contrast to previous studies, we found no evidence for an effect of BDNF genotype or met load during episodic memory encoding. Met allele carriers showed increased activation during successful retrieval in right hippocampus but this was contrast-specific and unaffected by met allele load. These results...

  17. MET Expression in Primary and Metastatic Clear Cell Renal Cell Carcinoma: Implications of Correlative Biomarker Assessment to MET Pathway Inhibitors

    Directory of Open Access Journals (Sweden)

    Brian Shuch

    2015-01-01

    Full Text Available Aims. Inhibitors of the MET pathway hold promise in the treatment for metastatic kidney cancer. Assessment of predictive biomarkers may be necessary for appropriate patient selection. Understanding MET expression in metastases and the correlation to the primary site is important, as distant tissue is not always available. Methods and Results. MET immunofluorescence was performed using automated quantitative analysis and a tissue microarray containing matched nephrectomy and distant metastatic sites from 34 patients with clear cell renal cell carcinoma. Correlations between MET expressions in matched primary and metastatic sites and the extent of heterogeneity were calculated. The mean expression of MET was not significantly different between primary tumors when compared to metastases (P=0.1. MET expression weakly correlated between primary and matched metastatic sites (R=0.5 and a number of cases exhibited very high levels of discordance between these tumors. Heterogeneity within nephrectomy specimens compared to the paired metastatic tissues was not significantly different (P=0.39. Conclusions. We found that MET expression is not significantly different in primary tumors than metastatic sites and only weakly correlates between matched sites. Moderate concordance of MET expression and significant expression heterogeneity may be a barrier to the development of predictive biomarkers using MET targeting agents.

  18. Awakening interest in the natural sciences - BASF's Kids' Labs.

    Science.gov (United States)

    Lang, Cinthia

    2012-01-01

    At BASF's Ludwigshafen headquarters, kids and young adults in grades 1-13 can learn about chemistry in the Kids' Labs. Different programs exist for different levels of knowledge. In the two 'Hands-on Lab H(2)O & Co.' Kids' Labs, students from grades 1-6 explore the secrets of chemistry. BASF Kids' Labs have now been set up in over 30 countries. In Switzerland alone, almost 2,000 students have taken part in the 'Water Loves Chemistry' Kids' Lab since it was started in 2011. In Alsace, 600 students have participated to date. In the Teens' Lab 'Xplore Middle School', middle school students explore five different programs with the themes 'substance labyrinth', 'nutrition', 'coffee, caffeine & co.', 'cosmetics' and 'energy'. Biotechnological methods are the focus of the Teens' Lab 'Xplore Biotech' for students taking basic and advanced biology courses. In the 'Xplore High School' Teens' Lab, chemistry teachers present their own experimental lab instruction for students in basic and advanced chemistry courses. The Virtual Lab has been expanding the offerings of the BASF Kids' Labs since 2011. The online lab was developed by the company for the International Year Of Chemistry and gives kids and young adults the opportunity to do interactive experiments outside of the lab.

  19. Aptamers Binding to c-Met Inhibiting Tumor Cell Migration.

    Directory of Open Access Journals (Sweden)

    Birgit Piater

    Full Text Available The human receptor tyrosine kinase c-Met plays an important role in the control of critical cellular processes. Since c-Met is frequently over expressed or deregulated in human malignancies, blocking its activation is of special interest for therapy. In normal conditions, the c-Met receptor is activated by its bivalent ligand hepatocyte growth factor (HGF. Also bivalent antibodies can activate the receptor by cross linking, limiting therapeutic applications. We report the generation of the RNA aptamer CLN64 containing 2'-fluoro pyrimidine modifications by systematic evolution of ligands by exponential enrichment (SELEX. CLN64 and a previously described single-stranded DNA (ssDNA aptamer CLN3 exhibited high specificities and affinities to recombinant and cellular expressed c-Met. Both aptamers effectively inhibited HGF-dependent c-Met activation, signaling and cell migration. We showed that these aptamers did not induce c-Met activation, revealing an advantage over bivalent therapeutic molecules. Both aptamers were shown to bind overlapping epitopes but only CLN3 competed with HGF binding to cMet. In addition to their therapeutic and diagnostic potential, CLN3 and CLN64 aptamers exhibit valuable tools to further understand the structural and functional basis for c-Met activation or inhibition by synthetic ligands and their interplay with HGF binding.

  20. Massage bij verpleeghuisbewoners met ernstige dementie: een waardevolle interventie.

    NARCIS (Netherlands)

    Inhulsen, M.B.; Verkaik, R.; Busch, M.; Francke, A.

    2016-01-01

    Zorgverleners vinden dat massage een waardevolle bijdrage levert aan de zorg voor verpleeghuisbewoners met ernstige dementie. Met name in het maken van contact en het verminderen van onrust. Dit blijkt uit een pilot uitgevoerd door zorgorganisatie Laurens, het Van Praag Instituut en

  1. Ringonderzoek : bepaling van coccidiostaticagehalte in diervoeders, met behulp van turbidimetrie

    NARCIS (Netherlands)

    Broex, N.J.G.; Huf, F.

    1988-01-01

    Voor de gehalte bepaling van monensin, salinomycine en narasin in diervoeders is de zg. turbidimetrische methode geringtest door 12 laboratoria. Ieder laboratorium heeft 9 monsters ontvangen, resp. 3 voormengsels en 6 diervoeders met monensin, salinomycine of narasin. De monsters zijn onderzocht met

  2. De kracht van sport : Sporten voor kinderen met gedragsproblemen

    NARCIS (Netherlands)

    dr. Remo Mombarg; Arjan Pruim

    2016-01-01

    In deze presentatie staat centraal hoe het bewegingsonderwijs kan worden aangepast op kinderen met een beperking. We weten dat kinderen met een beperking duidelijk minder vaak sporten en/of lid zijn van een vereniging. Desondanks heeft sport ook voor deze kinderen een betekenis. Zo kan sport een

  3. Wat doet sport met kinderen? : 'Inspiratiedag Aangepast Sporten’

    NARCIS (Netherlands)

    dr. Remo Mombarg

    2016-01-01

    Leren sporten is niet voor iedereen vanzelfsprekend. Zo heeft sport voor kinderen met een beperking vaak een andere betekenis dan voor kinderen zonder een beperking en zijn er voor kinderen met een beperking meer drempels om lid te worden van een sportvereniging. Drie belangrijke aspecten; de

  4. Invloed krachtvoerniveau op vleesproduktiekenmerken van Piemontese met zwartbont kruislingstieren

    NARCIS (Netherlands)

    Hanekamp, W.J.A.

    1989-01-01

    Met 3 ronden van elk 36 Piemontese X zwartbonte kruislingstieren is het effect van extra krachtvoer vergeleken met de normaal gangbare gift naast onbeperkt snijmaoskuil. De stieren waren gehuisvest in een natuurlijk geventileerde stal (space-boarding)en op een volledige roostervloer.

  5. Success, but Slowly, as Met School Redefines Learning

    Science.gov (United States)

    Pearson, George

    2012-01-01

    Seven Oaks Met School, the only high school in Canada that is part of the U.S.-based Big Picture Learning network of innovative schools, graduated its first class this spring. Internships with businesses and institutions in the community are a core element of the Met School experience. Students report on their internship experience, as well as on…

  6. Ontwerpen met biobased plastics : unieke eigenschappen en inspirerende toepassingsmogelijkheden

    NARCIS (Netherlands)

    Oskam, Inge; de Jong, Matthijs; Lepelaar, Mark; ten Kate, Rogier

    ‘Ontwerpen met biobased plastics’ is de eindpublicatie van het project “Design Challenges with Biobased Plastics”. In dit onderzoeksproject deed de HvA, samen met diverse mkb-bedrijven onderzoek naar de kennis een tools die ontwerpers nodig hebben om biobased plastics, kunststoffen van hernieuwbare

  7. Ultrafiltration Lactic Acid Bacteria (LAB in mung Beans Broth by Mixed LAB Culture

    Directory of Open Access Journals (Sweden)

    Aspiyanto Aspiyanto

    2014-06-01

    Full Text Available Increasing Lactic Acid Bacteria (LAB concentration in fermented broth of mung beans by mixed culture of Lactobacillus sp. and Streptococcus thermophillus through ultrafiltration (UF (20,000 MWCO at flow rate of ~8.87 L/min, room temperature and pressure 5 and 7 bars for 0, 30, 60, 90 and 120 minutes was performed. The results showed that pressure and time affected on UF performance, total solids, total protein and total number of LAB. Optimal time at pressure 5 bar was reached 60 minutes with flux 11.94 L/m2.hour, total solids 13.9423%, total protein 8.95%, total LAB 6.18 log CFU/mL, Robs of total solids 3.45%, total protein  58.67%, LAB 100% and DC 1.38 folds. The best time at 7 bar was reached 30 minutes with flux 16.16 L/m2.hour, total solids 12.2879%, total protein 4.41%, total LAB 6.04 Log CFU/mL, Robs of total solids 11.98%, total protein 45.76%, LAB 99.5 and DC 1.16 folds.

  8. BioMet Toolbox: genome-wide analysis of metabolism

    DEFF Research Database (Denmark)

    Cvijovic, M.; Olivares Hernandez, Roberto; Agren, R.

    2010-01-01

    standardized simulations. Model files for various model organisms (fungi and bacteria) are included. Overall, the BioMet Toolbox serves as a valuable resource for exploring the capabilities of these metabolic networks. BioMet Toolbox is freely available at www.sysbio.se/BioMet/....... models. Systematic analysis of biological processes by means of modelling and simulations has made the identification of metabolic networks and prediction of metabolic capabilities under different conditions possible. For facilitating such systemic analysis, we have developed the BioMet Toolbox, a web......-based resource for stoichiometric analysis and for integration of transcriptome and interactome data, thereby exploiting the capabilities of genome-scale metabolic models. The BioMet Toolbox provides an effective user-friendly way to perform linear programming simulations towards maximized or minimized growth...

  9. CELSTEC Learning Labs: Mobile App Development for Education and Training

    NARCIS (Netherlands)

    Specht, Marcus

    2011-01-01

    Specht, M. (2011). CELSTEC Learning Labs: Mobile App Development for Education and Training. Presentation given in Workshop at CELSTEC Learning Lab for Bluetea. February, 21, 2011, Heerlen, The Netherlands.

  10. Needsfinding in living labs : A structured research approach

    NARCIS (Netherlands)

    Savelkoul, L.E.M.; Peutz, M.

    Living labs enable innovations to be facilitated and implemented quickly and efficiently. A key element of the living lab approach is the active involvement of users. In this article, we examine a structured needsfinding phase of a living lab infrastructure project within the context of bicycle

  11. Experiential Learning of Digital Communication Using LabVIEW

    Science.gov (United States)

    Zhan, Wei; Porter, Jay R.; Morgan, Joseph A.

    2014-01-01

    This paper discusses the design and implementation of laboratories and course projects using LabVIEW in an instrumentation course. The pedagogical challenge is to enhance students' learning of digital communication using LabVIEW. LabVIEW was extensively used in the laboratory sessions, which better prepared students for the course projects. Two…

  12. Introduction to Computing: Lab Manual. Faculty Guide [and] Student Guide.

    Science.gov (United States)

    Frasca, Joseph W.

    This lab manual is designed to accompany a college course introducing students to computing. The exercises are designed to be completed by the average student in a supervised 2-hour block of time at a computer lab over 15 weeks. The intent of each lab session is to introduce a topic and have the student feel comfortable with the use of the machine…

  13. Cassandra - WP400 - final report of living lab 2

    NARCIS (Netherlands)

    Engler, M.; Klievink, A.J.

    2014-01-01

    This CASSANDRA LL2 final deliverable contains all information regarding the CASSANDRA Living Lab Europe – USA via Bremerhaven including information from two intermediate reports (CASSANDRA D4.21 and D4.22) about the very same Living Lab handed in during runtime of the Living Lab. CASSANDRA Living

  14. The NOAO Data Lab PHAT Photometry Database

    Science.gov (United States)

    Olsen, Knut; Williams, Ben; Fitzpatrick, Michael; PHAT Team

    2018-01-01

    We present a database containing both the combined photometric object catalog and the single epoch measurements from the Panchromatic Hubble Andromeda Treasury (PHAT). This database is hosted by the NOAO Data Lab (http://datalab.noao.edu), and as such exposes a number of data services to the PHAT photometry, including access through a Table Access Protocol (TAP) service, direct PostgreSQL queries, web-based and programmatic query interfaces, remote storage space for personal database tables and files, and a JupyterHub-based Notebook analysis environment, as well as image access through a Simple Image Access (SIA) service. We show how the Data Lab database and Jupyter Notebook environment allow for straightforward and efficient analyses of PHAT catalog data, including maps of object density, depth, and color, extraction of light curves of variable objects, and proper motion exploration.

  15. New mission for the national labs

    International Nuclear Information System (INIS)

    Weisman, J.

    1995-01-01

    As a testing moratorium takes hold, the future of the weapons laboratories may lie in a $3 billion package of science projects meant to keep the arsenal reliable-and weapons-designing talents sharp. When President Clinton declared an end to all nuclear testing a month ago, he offered the nation's three weapons laboratories an enormous, expensive pacifier-a $3 billion package of scientific projects to replace testing. The labs swallowed hard, choked back their conviction that explosive testing is the best and cheapest means of ensuring the reliability of the nation's nuclear stockpile, and took the bait. The lab directors duly issued statements embracing the test ban-providing the new program materializes

  16. New mission for the national labs

    Energy Technology Data Exchange (ETDEWEB)

    Weisman, J.

    1995-10-06

    As a testing moratorium takes hold, the future of the weapons laboratories may lie in a $3 billion package of science projects meant to keep the arsenal reliable-and weapons-designing talents sharp. When President Clinton declared an end to all nuclear testing a month ago, he offered the nation`s three weapons laboratories an enormous, expensive pacifier-a $3 billion package of scientific projects to replace testing. The labs swallowed hard, choked back their conviction that explosive testing is the best and cheapest means of ensuring the reliability of the nation`s nuclear stockpile, and took the bait. The lab directors duly issued statements embracing the test ban-providing the new program materializes.

  17. Implementation of a Mobile Accessible Remote Lab

    Directory of Open Access Journals (Sweden)

    Danilo Garbi Zutin

    2008-07-01

    Full Text Available The purpose of the proposed research is to designand implement a LabVIEW-based remote lab client to runon a TCP/IP enabled PDA (Personal Digital Assistantdevice, thus teaching using this wireless m-learning systemwill not be limited by time and location. In addition,resources and equipments can be integrated and shared tothe extent that critically events can be monitored andhandled in time. An environment will be created to trainstudents to handle factory automation, data acquisition,data management, and manufacturing processes usingmobile devices. Furthermore, the integration and sharing oflab equipments via the Internet is a kind of teachingenvironment which promotes learning interests andefficiency using mobile devices.

  18. Technology Roadmap: Lab-on-a-Chip

    Directory of Open Access Journals (Sweden)

    Pattharaporn Suntharasaj

    2010-04-01

    Full Text Available With the integration of microfluidic and MEMS technologies, biochips such as the lab-on-a-chip (LOC devices are at the brink of revolutionizing the medical disease diagnostics industries. Remarkable advancements in the biochips industry are making products resembling Star Trek.s "tricorder" and handheld medical scanners a reality. Soon, doctors can screen for cancer at the molecular level without costly and cumbersome equipments, and discuss treatment plans based on immediate lab results. This paper develops a roadmap for a hypothetical company (XI which is seeking to be successful in this market. The roadmapping process starts with gathering data through literature research and expert opinions, and progress through defining the market/product/technology layers, linking and integrating these layers, and finally creating a labon-a-chip for disease diagnostics technology roadmap.

  19. Lab-on-a-Chip Multiplex Assays.

    Science.gov (United States)

    Peter, Harald; Wienke, Julia; Bier, Frank F

    2017-01-01

    Lab-on-a-chip multiplex assays allow a rapid identification of multiple parameters in an automated manner. Here we describe a lab-based preparation followed by a rapid and fully automated DNA microarray hybridization and readout in less than 10 min using the Fraunhofer in vitro diagnostics (ivD) platform to enable rapid identification of bacterial species and detection of antibiotic resistance. The use of DNA microarrays allows a fast adaptation of new biomarkers enabling the identification of different genes as well as single-nucleotide-polymorphisms (SNPs) within these genes. In this protocol we describe a DNA microarray developed for identification of Staphylococcus aureus and the mecA resistance gene.

  20. A comparative study between met & unmet need groups of contraception in rural area of Maharashtra, India

    Directory of Open Access Journals (Sweden)

    Harsha M Solanki

    2013-03-01

    Full Text Available Objectives To compare met & unmet need groups of contraception with socio-economic, demographic, accessibility & family Planning (FP related factors. Methods Community based cross-sectional, comparative study was conducted among 363 married women of reproductive age groups in rural area selected by stratified simple random technique. After collecting preliminary information, the study population then divided into two groups based on their contraceptive use i.e. MET Group & UNMET NEED Groups. Then the role of socio-economic, demographic, accessibility & family Planning (FP related factors were studies to determine contraceptive use between these groups. Results Mean age of study subjects was 24.12 ± 4.45 years & average number of children per women was 2.02. Males were more literate than females (69.1% Vs 47.2%. 51.8% women were belonging to lower socio-economic status. Early marriages were still prevalent in this study (53.7%. Prevalence of met group of contraception was 59.2% & that of unmet need for contraception was 44.1%. Met groups were mainly from 20-29 years age group (46.6%; most of them (46.8% were literate & were from high socio-economic group (30.9% compared to unmet need groups. On comparison to unmet groups, most of the met group (33.9% got married after 18 years of age, residing within 5km area (26.4%, had visited to FP centre (49.0% & ever visited by FP staff (43.3%. Conclusion Education, income, marriage age, accessibility, FP staff related factors definitely has role among met & unmet need groups in their contraceptive use.

  1. BDNF val66met Polymorphism Affects Aging of Multiple Types of Memory

    Science.gov (United States)

    Kennedy, Kristen M.; Reese, Elizabeth D.; Horn, Marci M.; Sizemore, April N.; Unni, Asha K.; Meerbrey, Michael E.; Kalich, Allan G.; Rodrigue, Karen M.

    2014-01-01

    The BDNF val66met polymorphism (rs6265) influences activity-dependent secretion of brain-derived neurotrophic factor in the synapse, which is crucial for learning and memory. Individuals homozygous or heterozygous for the met allele have lower BDNF secretion than val homozygotes and may be at risk for reduced declarative memory performance, but it remains unclear which types of declarative memory may be affected and how aging of memory across the lifespan is impacted by the BDNF val66met polymorphism. This cross-sectional study investigated the effects of BDNF polymorphism on multiple indices of memory (item, associative, prospective, subjective complaints) in a lifespan sample of 116 healthy adults aged 20-93 years. Advancing age showed a negative effect on item, associative and prospective memory, but not on subjective memory complaints. For item and prospective memory, there were significant age x BDNF group interactions, indicating the adverse effect of age on memory performance across the lifespan was much stronger in the BDNF met carriers than for the val homozygotes. BDNF met carriers also endorsed significantly greater subjective memory complaints, regardless of age, and showed a trend (p memory performance compared to val homozygotes. These results suggest that genetic predisposition to the availability of brain-derived neurotrophic factor, by way of the BDNF val66met polymorphism, exerts an influence on multiple indices of episodic memory – in some cases in all individuals regardless of age (subjective memory and perhaps associative memory), in others as an exacerbation of age-related differences in memory across the lifespan (item and prospective memory). PMID:25264352

  2. co_LAB @ Web We Want

    OpenAIRE

    Thayne, Martyn; Cooper, Graham; Field, James; McCarthy, Clive; Vickers, Richard; Lawlor, Louise; West, Andrew

    2015-01-01

    co_LAB projects typically involve working with interdisciplinary groups of students, using discovery-based learning methods to explore questions, concerns and issues within digital culture and the incorporation of digital media into aspects of everyday life. Most recently the group participated in the 'Web We Want Festival' at the Southbank Arts Centre in London, which was part of Sir Tim Berners-Lee's campaign to develop a 'Magna Carta for the digital age'. In the week leading up to the fest...

  3. LAB bacteriocin applications in the last decade

    OpenAIRE

    Ma. del Rocío López-Cuellar; Adriana-Inés Rodríguez-Hernández; Norberto Chavarría-Hernández

    2016-01-01

    In the early 2000s, the expectations about bacteriocins produced by lactic acid bacteria (LABs) were aimed at food applications. However, the effectiveness of bacteriocins against undesirable micro-organisms opened endless possibilities for innovative research. In the present review, we collected a database including 429 published papers and 245 granted patents (from 2004 to 2015). Based on bibliometric analysis, the progress of bacteriocin research in the last 11 years was discussed in detai...

  4. Report to Lincoln Labs on TWPAs

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Carosi, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Woollett, N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Holland, E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Horsley, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Qu, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Materise, N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Drury, O. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chapline, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Friedrich, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-26

    This past spring LLNL’s Quantum Sensor’s team received two TWPA amplifiers from Lincoln Labs along with a data-sheet explaining handling, operations and expected performance. Here we will outline some of the initial tests performed on this amplifiers as part of LLNL’s Quantum Sensors Strategic Initiative (QSSI). Initial testing confirmed that both amplifiers worked and provided gain and SNR improvement similar to that called out in the data-sheets provided.

  5. Berkeley's Advanced Labs for Undergraduate Astronomy Majors

    Science.gov (United States)

    Heiles, C.

    1998-12-01

    We currently offer three advanced laboratory courses for undergraduate majors: optical, IR, and radio. These courses contain both intellectual and practical content; in this talk we focus on the radio lab as a representative example. The first half of the semester concentrates on fundamentals of microwave electronics and radio astronomy techniques in four formal laboratory exercises which emphasize hands-on use of microwave devices, laboratory instruments, and computer-controlled data taking. The second half of the course emphasizes astronomy, using a horn with ~ 1 m(2) aperture to map the HI in the Galaxy and a two-element interferometer composed of ~ 1 m diameter dishes on a ~ 10 m baseline to measure accurate positions of radio sources and accurate diameters for the Sun and Moon. These experiments and observations offer ideal opportunities for teaching coordinates, time, rotation matrices, data reduction techniques, least squares, signal processing, image processing, Fourier transforms, and laboratory and astronomical instrumentation. The students can't get along without using computers as actually used by astronomers. We stay away from packaged software such as IRAF, which are ``black boxes''; rather, students learn far more by writing their own software, usually for the first time. They use the IDL language to take and reduce data and prepare them for the lab reports. We insist on quality reports---including tables, postscript graphs and images, correct grammar, spelling, and all the rest---and we strongly urge (successfully!) the students to use LATEX. The other two lab courses have the same emphasis: the guiding spirit is to place the students in a real-life research-like situation. There is too much to do, so students perform the work in small groups of 3 or 4 and groups are encouraged to share their knowledge. Lab reports are written individually. These courses are very demanding, requiring an average of 20 hours per week from the students (and probably

  6. Berkeley Lab Computing Sciences: Accelerating Scientific Discovery

    International Nuclear Information System (INIS)

    Hules, John A.

    2008-01-01

    Scientists today rely on advances in computer science, mathematics, and computational science, as well as large-scale computing and networking facilities, to increase our understanding of ourselves, our planet, and our universe. Berkeley Lab's Computing Sciences organization researches, develops, and deploys new tools and technologies to meet these needs and to advance research in such areas as global climate change, combustion, fusion energy, nanotechnology, biology, and astrophysics

  7. MET and AKT genetic influence on facial emotion perception.

    Directory of Open Access Journals (Sweden)

    Ming-Teng Lin

    Full Text Available BACKGROUND: Facial emotion perception is a major social skill, but its molecular signal pathway remains unclear. The MET/AKT cascade affects neurodevelopment in general populations and face recognition in patients with autism. This study explores the possible role of MET/AKT cascade in facial emotion perception. METHODS: One hundred and eighty two unrelated healthy volunteers (82 men and 100 women were recruited. Four single nucleotide polymorphisms (SNP of MET (rs2237717, rs41735, rs42336, and rs1858830 and AKT rs1130233 were genotyped and tested for their effects on facial emotion perception. Facial emotion perception was assessed by the face task of Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT. Thorough neurocognitive functions were also assessed. RESULTS: Regarding MET rs2237717, individuals with the CT genotype performed better in facial emotion perception than those with TT (p = 0.016 by ANOVA, 0.018 by general linear regression model [GLM] to control for age, gender, and education duration, and showed no difference with those with CC. Carriers with the most common MET CGA haplotype (frequency = 50.5% performed better than non-carriers of CGA in facial emotion perception (p = 0.018, df = 1, F = 5.69, p = 0.009 by GLM. In MET rs2237717/AKT rs1130233 interaction, the C carrier/G carrier group showed better facial emotion perception than those with the TT/AA genotype (p = 0.035 by ANOVA, 0.015 by GLM, even when neurocognitive functions were controlled (p = 0.046 by GLM. CONCLUSIONS: To our knowledge, this is the first study to suggest that genetic factors can affect performance of facial emotion perception. The findings indicate that MET variances and MET/AKT interaction may affect facial emotion perception, implicating that the MET/AKT cascade plays a significant role in facial emotion perception. Further replication studies are needed.

  8. MET and AKT genetic influence on facial emotion perception.

    Science.gov (United States)

    Lin, Ming-Teng; Huang, Kuo-Hao; Huang, Chieh-Liang; Huang, Yu-Jhen; Tsai, Guochuan E; Lane, Hsien-Yuan

    2012-01-01

    Facial emotion perception is a major social skill, but its molecular signal pathway remains unclear. The MET/AKT cascade affects neurodevelopment in general populations and face recognition in patients with autism. This study explores the possible role of MET/AKT cascade in facial emotion perception. One hundred and eighty two unrelated healthy volunteers (82 men and 100 women) were recruited. Four single nucleotide polymorphisms (SNP) of MET (rs2237717, rs41735, rs42336, and rs1858830) and AKT rs1130233 were genotyped and tested for their effects on facial emotion perception. Facial emotion perception was assessed by the face task of Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT). Thorough neurocognitive functions were also assessed. Regarding MET rs2237717, individuals with the CT genotype performed better in facial emotion perception than those with TT (p = 0.016 by ANOVA, 0.018 by general linear regression model [GLM] to control for age, gender, and education duration), and showed no difference with those with CC. Carriers with the most common MET CGA haplotype (frequency = 50.5%) performed better than non-carriers of CGA in facial emotion perception (p = 0.018, df = 1, F = 5.69, p = 0.009 by GLM). In MET rs2237717/AKT rs1130233 interaction, the C carrier/G carrier group showed better facial emotion perception than those with the TT/AA genotype (p = 0.035 by ANOVA, 0.015 by GLM), even when neurocognitive functions were controlled (p = 0.046 by GLM). To our knowledge, this is the first study to suggest that genetic factors can affect performance of facial emotion perception. The findings indicate that MET variances and MET/AKT interaction may affect facial emotion perception, implicating that the MET/AKT cascade plays a significant role in facial emotion perception. Further replication studies are needed.

  9. MetNet Precursor - Network Mission to Mars

    Science.gov (United States)

    Harri, Arri-Matti

    2010-05-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The first MetNet vehicle, MetNet Precursor, slated for launch in 2011. The MetNet development work started already in 2001. The actual practical Precursor Mission development work started in January 2009 with participation from various space research institutes and agencies. The scientific rationale and goals as well as key mission solutions will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Time-resolved in situ Martian meteorological measurements acquired by the Viking, Mars Pathfinder and Phoenix landers and remote sensing observations by the Mariner 9, Viking, Mars Global Surveyor, Mars Odyssey and the Mars Express orbiters have provided the basis for our current understanding of the behavior of weather and climate on Mars. However, the available amount of data is still scarce and a wealth of additional in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes to address microscale and mesoscale atmospheric phenomena. Detailed characterization of the Martian atmospheric circulation patterns and climatological cycles requires simultaneous in situ atmospheric observations. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe

  10. Tele-Lab IT-Security: an Architecture for an online virtual IT Security Lab

    Directory of Open Access Journals (Sweden)

    Christoph Meinel

    2008-05-01

    Full Text Available Recently, Awareness Creation in terms of IT security has become a big thing – not only for enterprises. Campaigns for pupils try to highlight the importance of IT security even in the user’s early years. Common practices in security education – as seen in computer science courses at universities – mainly consist of literature and lecturing. In the best case, the teaching facility offers practical courses in a dedicated isolated computer lab. Additionally, there are some more or less interactive e-learning applications around. Most existing offers can do nothing more than impart theoretical knowledge or basic information. They all lack of possibilities to provide practical experience with security software or even hacker tools in a realistic environment. The only exceptions are the expensive and hard-to-maintain dedicated computer security labs. Those can only be provided by very few organizations. Tele-Lab IT-Security was designed to offer hands-on experience exercises in IT security without the need of additional hardware or maintenance expenses. The existing implementation of Tele-Lab even provides access to the learning environment over the Internet – and thus can be used anytime and anywhere. The present paper describes the extended architecture on which the current version of the Tele-Lab server is built.

  11. Combinatie van walnoten met grasproductie en reactie : verslag van resultaten en ervaringen van de eerste jaren met 'Multifunctionele beplantingen', als bouwsteen voor meervoudig duurzaam landgebruik

    NARCIS (Netherlands)

    Oosterbaan, A.; Berg, van den C.A.; Valk, H.

    2003-01-01

    In de omgeving van Winterswijk is vanaf 1999 10 ha multifunctionele beplantingen aangelegd, hoofdzakelijk van walnoot met gras. Overhoeken zijn ingeplant met vruchtstruiken. De eerste ervaringen met aanplant, grasbeheer, bijdrage aan recreatie en dergelijke zijn in dit rapport weergegeven.

  12. Intensieve veehouderij: met nieuwe producten samen naar gangbaar plus

    NARCIS (Netherlands)

    Kortstee, H.J.M.

    2007-01-01

    Samenwerkingverbanden van varkens- en pluimveehouders kunnen een geschikt instrument zijn om een nieuw product in de markt te zetten. Een succesvolle vermarkting vereist, naast een sterke initiatiefnemer met een overtuigend idee, ook krachtige partners in de keten en ondersteuning bij

  13. Leven met de varroamijt in de 21ste eeuw

    NARCIS (Netherlands)

    Blacquiere, T.; Cornelissen, B.; Smeekens, C.C.; Steen, van der J.J.M.

    2002-01-01

    Overzicht van voorhanden bestrijdingsmethoden tegen Varroa destructor op de korte termijn en vooruitzichten voor de bestrijding op langere termijn. In de nabije toekomst gaat het om bestrijding met diergeneesmiddelen van natuurlijke oorsprong (mierenzuur, oxaalzuur, thymol) in het kader van een

  14. Mars MetNet Mission - Martian Atmospheric Observational Post Network

    Science.gov (United States)

    Hari, Ari-Matti; Haukka, Harri; Aleksashkin, Sergey; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Siikonen, Timo; Palin, Matti

    2017-04-01

    A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. 1. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. 2. Strawman Scientific Payload The strawman payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: - MetBaro Pressure device - MetHumi Humidity device - MetTemp Temperature sensors Optical devices: - PanCam Panoramic - MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer - DS Dust sensor Composition and Structure Devices: Tri-axial magnetometer MOURA Tri-axial System Accelerometer The descent processes dynamic properties are monitored by a special 3-axis

  15. Mars MetNet Mission - Martian Atmospheric Observational Post Network

    Science.gov (United States)

    Harri, A.-M.; Haukka, H.; Aleksashkin, S.; Arruego, I.; Schmidt, W.; Genzer, M.; Vazquez, L.; Siikonen, T.; Palin, M.

    2017-09-01

    A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

  16. Role of Met Axis in Head and Neck Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Yiru, E-mail: xuyiru@umich.edu; Fisher, Gary J., E-mail: xuyiru@umich.edu [Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 (United States)

    2013-11-26

    Head and neck cancer is the sixth most common type of cancer worldwide. Despite advances in aggressive multidisciplinary treatments, the 5-year survival rate for this dreadful disease is only 50%, mostly due to high rate of recurrence and early involvement of regional lymph nodes and subsequent metastasis. Understanding the molecular mechanisms responsible for invasion and metastasis is one of the most pressing goals in the field of head and neck cancer. Met, also known as hepatocyte growth factor receptor (HGFR), is a member of the receptor protein tyrosine kinase (RPTK) family. There is compelling evidence that Met axis is dysregulated and plays important roles in tumorigenesis, progression, metastasis, angiogenesis, and drug resistance in head and neck cancer. We describe in this review current understanding of Met axis in head and neck cancer biology and development of therapeutic inhibitors targeting Met axis.

  17. The Dynamics and Facilitation of a Living Lab Construct

    DEFF Research Database (Denmark)

    Brønnum, Louise; Nielsen, Louise Møller

    2013-01-01

    During the last decade Living Labs have established itself as an attractive innovation approach. Living Labs are an interesting construction because it offers a collaboration platform for dynamic interaction with users in all the project phases. Living Labs frame knowledge about actors in their own...... settings, in which new opportunities for innovation can be discovered. However, the practical management of a Living Lab is often a great challenge. It involves managing several actors, who are working with different agendas and within very different development traditions. The managing of a Living Lab...... and the different actors, processes and methods are therefore interesting to put into perspective as it contains opportunities for staging a well‐functioning Living Lab. This paper contributes to unfolding and discussing some of the main challenges in managing a Living Lab while keeping the different actors engaged...

  18. MMPM - Mission implementation of Mars MetNet Precursor

    Science.gov (United States)

    Harri, A.-M.

    2009-04-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The key technical aspects and solutions of the mission will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. This development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development.

  19. Beyond Classroom, Lab, Studio and Field

    Science.gov (United States)

    Waller, J. L.; Brey, J. A.; DeMuynck, E.; Weglarz, T. C.

    2017-12-01

    When the arts work in tandem with the sciences, the insights of these disciplines can be easily shared and teaching and learning are enriched. Our shared experiences in classroom/lab/studio instruction and in art and science based exhibitions reward all involved. Our individual disciplines cover a wide range of content- Art, Biology, Geography, Geology- yet we connect on aspects that link to the others'. We easily move from lab to studio and back again as we teach—as do our students as they learn! Art and science education can take place outside labs and studios through study abroad, international workshops, museum or gallery spaces, and in forums like the National Academies' programs. We can reach our neighbors at local public gatherings, nature centers and libraries. Our reach is extended in printed publications and in conferences. We will describe some of our activities listed above, with special focus on exhibitions: "Layers: Places in Peril"; "small problems, BIG TROUBLE" and the in-progress "River Bookends: Headwaters, Delta and the Volume of Stories In Between". Through these, learning and edification take place between the show and gallery visitors and is extended via class visits and related assignments, field trips for child and adult learners, interviews, films and panel presentations. These exhibitions offer the important opportunities for exhibit- participating scientists to find common ground with each other about their varied work. We will highlight a recent collaborative show opening a new university-based environmental research center and the rewarding activities there with art and science students and professors. We will talk about the learning enhancement added through a project that brought together a physical geography and a painting class. We will explore how students shared the form and content of their research projects with each other and then, became the educators through paintings and text of their geoscience topics on gallery walls.

  20. E-Labs - Learning with Authentic Data

    Energy Technology Data Exchange (ETDEWEB)

    Bardeen, Marjorie G. [Fermilab; Wayne, Mitchell [Notre Dame U.

    2016-01-01

    the success teachers have had providing an opportunity for students to: • Organize and conduct authentic research. • Experience the environment of scientific collaborations. • Possibly make real contributions to a burgeoning scientific field. We've created projects that are problem-based, student driven and technology dependent. Students reach beyond classroom walls to explore data with other students and experts and share results, publishing original work to a worldwide audience. Students can discover and extend the research of other students, modeling the processes of modern, large-scale research projects. From start to finish e-Labs are student-led, teacher-guided projects. Students need only a Web browser to access computing techniques employed by professional researchers. A Project Map with milestones allows students to set the research plan rather than follow a step-by-step process common in other online projects. Most importantly, e-Labs build the learning experience around the students' own questions and let them use the very tools that scientists use. Students contribute to and access shared data, most derived from professional research databases. They use common analysis tools, store their work and use metadata to discover, replicate and confirm the research of others. This is where real scientific collaboration begins. Using online tools, students correspond with other research groups, post comments and questions, prepare summary reports, and in general participate in the part of scientific research that is often left out of classroom experiments. Teaching tools such as student and teacher logbooks, pre- and post-tests and an assessment rubric aligned with learner outcomes help teachers guide student work. Constraints on interface designs and administrative tools such as registration databases give teachers the "one-stop-shopping" they seek for multiple e-Labs. Teaching and administrative tools also allow us to track usage and assess the

  1. Charpy V, an application in Mat lab

    International Nuclear Information System (INIS)

    Castillo M, J.A.; Torres V, M.

    2003-01-01

    The obtained results with the system Charpy V V 1 designed in Mat lab for the estimate of parameters of three mathematical models are shown. The adjustment of data is used to determine the fracture energy, the lateral expansion and the percentage of ductility of steels coming from the reactor vessels of Laguna Verde, Veracruz. The data come from test tubes type Charpy V of irradiated material and not irradiated. To verify our results they were compared with those obtained by General Electric of data coming from the Laguna Verde nuclear power plant. (Author)

  2. DOSAR/CalLab Operations Manual

    Energy Technology Data Exchange (ETDEWEB)

    Bogard, J.S.

    2000-03-01

    The Life Sciences Division (LSD) of Oak Ridge National Laboratory (ORNL) has a long record of radiation dosimetry research, primarily using the Health Physics Research Reactor (HPRR) and the Dosimetry Applications Research (DOSAR) Program Calibration Laboratory (CalLab), referred to formerly as the Radiation Calibration Laboratory. These facilities have been used by a broad segment of the research community to perform a variety of experiments in areas including, but not limited to, radiobiology, radiation dosimeter and instrumentation development and calibration, and the testing of materials in a variety of radiation environments.

  3. Comparative genomics of Lactobacillus and other LAB

    DEFF Research Database (Denmark)

    Wassenaar, Trudy M.; Lukjancenko, Oksana

    2014-01-01

    The genomes of 66 LABs, belonging to five different genera, were compared for genome size and gene content. The analyzed genomes included 37 Lactobacillus genomes of 17 species, six Lactococcus lactis genomes, four Leuconostoc genomes of three species, six Streptococcus genomes of two species...... that of the others, with the two Streptococcus species having the shortest genomes. The widest distribution in genome content was observed for Lactobacillus. The number of tRNA and rRNA gene copies varied considerably, with exceptional high numbers observed for Lb. delbrueckii, while these numbers were relatively...

  4. COMT (Val158Met and BDNF (Val66Met Genes Polymorphism in Schizophrenia: A Case-Control Report

    Directory of Open Access Journals (Sweden)

    ramin saravani

    2017-10-01

    Full Text Available Objective: The effects of human brain-derived neurotropic factor (BDNF Val66Met (G>A and the human Catechol-O-methylTransferase (COMT Val158Met (G>A polymorphisms on Schizophrenia (SCZ risk were evaluated.Methods: This case control study included 92 SCZ patients and 92 healthy controls (HCs. Genotyping of both variants were conducted using Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR.Results: The findings showed that BDNF Val66Met (G>A variant increased the risk of SCZ (OR=2.008 95%CI=1.008-4.00, P=0.047, GA vs. GG, OR=3.876 95%CI=1.001-14.925, P=0.049. AA vs. GG, OR=2.272. 95%CI=1.204-4.347, P=0.011, GA+AA vs. GG, OR=2.22 95%CI=1.29-3.82. P=0.005, A vs. G. COMT Val158Met (G>A polymorphism was not associated with the risk/protective of SCZ.Conclusion: The results proposed that BDNF Val66Met (G>A polymorphism may increase the risk of SCZ development and did not support an association between COMT Val158Met (G>A variant and risk/protective of SCZ. Further studies and different ethnicities are recommended to confirm the findings.

  5. Test Report: Assembly and Structural Loading of Army Research Lab’s High Strength Low Alloy - Vanadium (HSLA - V) Bridge

    Science.gov (United States)

    2010-04-28

    Loading of Army Research Labs High Strength Low Alloy - Vanadium (HSLA - V) Bridge 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...Vanadium Technology Program developed a prototype bridge and then approached TARDEC to test and evaluate two-representative sections of bridge. The focus...join the assembled sections. A section designed along with a launch mechanism and crew choreography is suggested to optimize the time to cross the

  6. The Design of NetSecLab: A Small Competition-Based Network Security Lab

    Science.gov (United States)

    Lee, C. P.; Uluagac, A. S.; Fairbanks, K. D.; Copeland, J. A.

    2011-01-01

    This paper describes a competition-style of exercise to teach system and network security and to reinforce themes taught in class. The exercise, called NetSecLab, is conducted on a closed network with student-formed teams, each with their own Linux system to defend and from which to launch attacks. Students are expected to learn how to: 1) install…

  7. OpenLabNotes – An Electronic Laboratory Notebook Extension for OpenLabFramework

    Directory of Open Access Journals (Sweden)

    List Markus

    2015-09-01

    Full Text Available Electronic laboratory notebooks (ELNs are more accessible and reliable than their paper based alternatives and thus find widespread adoption. While a large number of commercial products is available, small- to mid-sized laboratories can often not afford the costs or are concerned about the longevity of the providers. Turning towards free alternatives, however, raises questions about data protection, which are not sufficiently addressed by available solutions. To serve as legal documents, ELNs must prevent scientific fraud through technical means such as digital signatures. It would also be advantageous if an ELN was integrated with a laboratory information management system to allow for a comprehensive documentation of experimental work including the location of samples that were used in a particular experiment. Here, we present OpenLabNotes, which adds state-of-the-art ELN capabilities to OpenLabFramework, a powerful and flexible laboratory information management system. In contrast to comparable solutions, it allows to protect the intellectual property of its users by offering data protection with digital signatures. OpenLabNotes effectively closes the gap between research documentation and sample management, thus making Open- LabFramework more attractive for laboratories that seek to increase productivity through electronic data management.

  8. Tools for application management at Jefferson Lab

    International Nuclear Information System (INIS)

    The Software Controls Group at Thomas Jefferson National Accelerator Facility (Jefferson Lab) is responsible for slow controls for many Jefferson Lab facilities. The Experimental Physics and Industrial Control System (EPICS) is used as the basis of these control systems. The Controls Group developed and maintains over 150 control applications running on over 100 I/O controllers (IOCs). With so many applications, it becomes increasingly difficult to maintain and upgrade older applications and still produce new applications. The difficulties became especially apparent this year as a major effort was undertaken to upgrade all control system applications to the newest versions of EPICS and VxWorks. Over the past few years, the Controls Group has worked on constructing a framework within which to develop and maintain applications more efficiently. As the framework has matured and applications have been structured to fit the framework, a number of tools have been developed to help with software maintenance and upgrades. This paper will describe some of these tools and how they are used to enhance the maintainability and reliability of the control system

  9. Control system reliability at Jefferson Lab

    International Nuclear Information System (INIS)

    At Thomas Jefferson National Accelerator Facility (Jefferson Lab), the availability of the control system is crucial to the operation of the accelerator for experimental programs. Jefferson Lab's control system, uses 68040 based microprocessors running VxWorks, Unix workstations, and a variety of VME, CAMAC. GPIB, and serial devices. The software consists of control system toolkit software, commercial packages, and over 200 custom and generic applications, some of which are highly complex. The challenge is to keep this highly diverse and still growing system, with over 162,000 control points, operating reliably, while managing changes and upgrades to both the hardware and software. Downtime attributable to the control system includes the time to troubleshoot and repair problems and the time to restore the machine to operation of the scheduled program. This paper describes the availability of the control system during the last year, the heaviest contributors to downtime and the response to problems. Strategies for improving the robustness of the control system am detailed and include changes in hardware, software, procedures and processes. The improvements range from the routine preventive hardware maintenance, to improving their ability to detect, predict and prevent problems. This paper also describes the software tools used to assist in control system troubleshooting, maintenance and failure recovery processes

  10. The evolution of Jefferson Lab's control system

    International Nuclear Information System (INIS)

    K. S. White; M. Bickley; W. Watson

    1999-01-01

    Thomas Jefferson National Accelerator Facility's (Jefferson Lab) accelerator controls were initially implemented as a proprietary in-house system. During machine commissioning, problems were encountered leading to a decision to migrate to the Experimental Physics and Industrial Controls System (EPICS). Since then, the accelerator and all other laboratory controls have been successfully converted. In addition to implementing Jefferson Lab's controls using EPICS, new data visualization tools have been developed and existing programs have been enhanced with new capabilities. In order to provide a more generic interface for high level applications development, a device abstraction layer, called Common DEVice (CDEV), was implemented. These additions have been made available to other laboratories and are in use at many sites, including some that do not use EPICS. Control System development is not limited to computer scientists; operators, engineers and physicists frequently add capabilities using EPICS, CDEV, Tel/tk, and other tools. These contributions have tailored the control system for many different types of customers. For the future, the authors envision more intelligent processing and more capable tools for data storage, retrieval and visualization

  11. Quality of Lab Appliances in Orthodontic Offices.

    Science.gov (United States)

    Pruzansky, D P; Park, J H

    Lab appliances are an integral part of orthodontics, from active treatment to retention. The quality and fit of an appliance can affect the treatment result and stability. This study aims to determine common points of failure in orthodontic appliances, and suggest methods to reduce this rate. A survey consisting of 23 questions was distributed to active members of the American Association of Orthodontists (AAO) via Survey Monkey. The most common appliance to need an adjustment was the wrap-around retainer, with the Hawley retainer as a close second. The least common appliance needing adjustment was the Essix/clear retainer. Respondents were asked which component of each appliance was most commonly responsible for an ill-fit. For Hawley and wrap-around retainers, clasps were the most common problem at 50%, whereas spring aligners had two components - clasps and labial bows, both at 38%. Ill-fitting Essix/clear retainers had gingival impingement (52%) closely followed by poor posterior seating (43%). Communication between the orthodontist and lab technician can be improved by establishing a quality assurance protocol for outgoing and incoming cases. The labial bow of Hawley's, wrap-arounds and spring aligners should be clearly demarcated on the casts. Impressions should be free of distortion and casts should be inspected for accuracy. Clear retainers and positioner should be trimmed to avoid gingival impingement. The type of clasp should be selected based on the anatomy of the teeth, and bands should be checked for accuracy of fit.

  12. Temperature quenching in LAB based liquid scintillator

    Science.gov (United States)

    Sörensen, A.; Hans, S.; Junghans, A. R.; Krosigk, B. v.; Kögler, T.; Lozza, V.; Wagner, A.; Yeh, M.; Zuber, K.

    2018-01-01

    The effect of temperature changes on the light output of LAB based liquid scintillator is investigated in a range from -5 to 30°C with α -particles and electrons in a small scale setup. Two PMTs observe the scintillator liquid inside a cylindrically shaped aluminum cuvette that is heated or cooled and the temperature dependent PMT sensitivity is monitored and corrected. The α -emitting isotopes in dissolved radon gas and in natural Samarium (bound to a LAB solution) excite the liquid scintillator mixtures and changes in light output with temperature variation are observed by fitting light output spectra. Furthermore, also changes in light output by compton electrons, which are generated from external calibration γ -ray sources, is analysed with varying temperature. Assuming a linear behaviour, a combined negative temperature coefficient of {(-0.29 ± 0.01)}{ %/°}C is found. Considering hints for a particle type dependency, electrons show {(-0.17 ± 0.02)}{ %/°}C, whereas the temperature dependency seems stronger for α -particles, with {(-0.35 ± 0.03)}{ %/°}C. Due to a high sampling rate, a pulse shape analysis can be performed and shows an enhanced slow decay component at lower temperatures, pointing to reduced non-radiative triplet state de-excitations.

  13. PC/104 Embedded IOCs at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    Jianxun Yan, Trent Allison, Sue Witherspoon, Anthony Cuffe

    2009-10-01

    Jefferson Lab has developed embedded IOCs based on PC/104 single board computers (SBC) for low level control systems. The PC/104 IOCs run EPICS on top of the RTEMS operating system. Two types of control system configurations are used in different applications, PC/104 SBC with commercial PC/104 I/O cards and PC/104 SBC with custom designed FPGA-based boards. RTEMS was built with CEXP shell to run on the PC/104 SBC. CEXP shell provides the function of dynamic object loading, which is similar to the widely used VxWorks operating system. Standard software configurations were setup for PC/104 IOC application development to provide a familiar format for new projects as well as ease the conversion of applications from VME based IOCs to PC/104 IOCs. Many new projects at Jefferson Lab are going to employ PC/104 SBCs as IOCs and some applications have already been running them for accelerator operations. The PC/104 - RTEMS IOC provides a free open source Real-Time Operating System (RTOS), low cost/maintenance, easily installed/ configured, flexible, and reliable solution for accelerator control and 12GeV Upgrade projects.

  14. Control system reliability at Jefferson Lab

    International Nuclear Information System (INIS)

    White, K.S.; Areti, H.; Garza, O.

    1997-01-01

    At Thomas Jefferson National Accelerator Facility (Jefferson Lab), the availability of the control system is crucial to the operation of the accelerator for experimental programs. Jefferson Lab's control system, uses 68040 based microprocessors running VxWorks, Unix workstations, and a variety of VME, CAMAC. GPIB, and serial devices. The software consists of control system toolkit software, commercial packages, and over 200 custom and generic applications, some of which are highly complex. The challenge is to keep this highly diverse and still growing system, with over 162,000 control points, operating reliably, while managing changes and upgrades to both the hardware and software. Downtime attributable to the control system includes the time to troubleshoot and repair problems and the time to restore the machine to operation of the scheduled program. This paper describes the availability of the control system during the last year, the heaviest contributors to downtime and the response to problems. Strategies for improving the robustness of the control system am detailed and include changes in hardware, software, procedures and processes. The improvements range from the routine preventive hardware maintenance, to improving their ability to detect, predict and prevent problems. This paper also describes the software tools used to assist in control system troubleshooting, maintenance and failure recovery processes

  15. Smartphones - the Geophysics Lab in Your Students' Pocket

    Science.gov (United States)

    Salaree, A.; Stein, S.; Saloor, N.; Elling, R. P.

    2017-12-01

    Many interesting topics are hard to demonstrate in geophysics classes without costly equipment and logistic hassles. For instance, the speed of P-waves in the Earth's crust is usually calculated using printed seismic sections from published studies, giving students little insight into the recording process. This is mainly due to the complex, costly, and weather-dependent logistics of conducting seismic reflection experiments using arrays of - either purchased or borrowed - expensive seismometers and recording units. Smartphones, which students own and are (perhaps unduly) comfortable with, have many otherwise expensive instruments as built-in sensors. These instruments are nifty tools that make labs easier, faster, and more fun. We use smartphones in several labs in an introductory geophysics class. In one, students use their phones to measure the latitude and longitude of a point on campus. Combining the data shows a nice spread of positions illustrating the precision of measurements, spatial trends in the scatter, and even differences between Android and iPhone data. Hence concepts about data that are often presented with ideal theoretical examples emerge from the students' measurements. Another uses the phones' accelerometers and available software to measure the speed of P-waves using a linear array of smartphones/seismometers along a table, similar to the procedure used in reflection seismology. In a third, students used their smartphones in an elevator to measure the acceleration of gravity in a moving reference frame, and thus explore key concepts that arise in many geophysical applications. These three applications illustrate the potential for using smartphones in a wide variety of geophysics teaching, much as their value is being increasingly recognized in other educational applications. Here are some links to an instructions document and a video from the seismic experiment: Instructions: http://www.earth.northwestern.edu/ amir/202/smartphone

  16. Hydrogen storage capacity of titanium met-cars

    Energy Technology Data Exchange (ETDEWEB)

    Akman, N [Department of Physics, Mersin University, 33342 Mersin (Turkey); Durgun, E [Department of Physics, Bilkent University, 06800 Ankara (Turkey); Yildirim, T [NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Ciraci, S [Department of Physics, Bilkent University, 06800 Ankara (Turkey)

    2006-10-18

    The adsorption of hydrogen molecules on the titanium metallocarbohedryne (met-car) cluster has been investigated by using the first-principles plane wave method. We have found that, while a single Ti atom at the corner can bind up to three hydrogen molecules, a single Ti atom on the surface of the cluster can bind only one hydrogen molecule. Accordingly, a Ti{sub 8}C{sub 12} met-car can bind up to 16 H{sub 2} molecules and hence can be considered as a high-capacity hydrogen storage medium. Strong interaction between two met-car clusters leading to the dimer formation can affect H{sub 2} storage capacity slightly. Increasing the storage capacity by directly inserting H{sub 2} into the met-car or by functionalizing it with an Na atom have been explored. It is found that the insertion of neither an H{sub 2} molecule nor an Na atom could further promote the H{sub 2} storage capacity of a Ti{sub 8}C{sub 12} cluster. We have also tested the stability of the H{sub 2}-adsorbed Ti{sub 8}C{sub 12} met-car with ab initio molecular dynamics calculations which have been carried out at room temperature.

  17. MetAmyl: a METa-predictor for AMYLoid proteins.

    Directory of Open Access Journals (Sweden)

    Mathieu Emily

    Full Text Available The aggregation of proteins or peptides in amyloid fibrils is associated with a number of clinical disorders, including Alzheimer's, Huntington's and prion diseases, medullary thyroid cancer, renal and cardiac amyloidosis. Despite extensive studies, the molecular mechanisms underlying the initiation of fibril formation remain largely unknown. Several lines of evidence revealed that short amino-acid segments (hot spots, located in amyloid precursor proteins act as seeds for fibril elongation. Therefore, hot spots are potential targets for diagnostic/therapeutic applications, and a current challenge in bioinformatics is the development of methods to accurately predict hot spots from protein sequences. In this paper, we combined existing methods into a meta-predictor for hot spots prediction, called MetAmyl for METapredictor for AMYLoid proteins. MetAmyl is based on a logistic regression model that aims at weighting predictions from a set of popular algorithms, statistically selected as being the most informative and complementary predictors. We evaluated the performances of MetAmyl through a large scale comparative study based on three independent datasets and thus demonstrated its ability to differentiate between amyloidogenic and non-amyloidogenic polypeptides. Compared to 9 other methods, MetAmyl provides significant improvement in prediction on studied datasets. We further show that MetAmyl is efficient to highlight the effect of point mutations involved in human amyloidosis, so we suggest this program should be a useful complementary tool for the diagnosis of these diseases.

  18. Requirements to be met by the operation manual

    International Nuclear Information System (INIS)

    1981-03-01

    The rule applies to the contents and the lay-out of the operating manual for stationary nuclear power plants. The draft contains: 1. General requirement to be met by the contents of the operating manual. The operating manual to be arranged in 4 parts (part 1: internal rules and regulations; part 2: operation overall plant; part 3: incidents; part 4: operation systems). Safety specifications to be included in the manual, the exemption being the system of technical documentation. 2. General requirements to be met by the lay-out of the operating manual. Comprehensibility; legibility; structure and subdivisions; arrangement of the instructions and design of the manuals cover. 3. Requirements to be met by part 1. Defining the various internal rules and regulations (personnel management); rules and regulations concerning inspections and shift work; maintenance and repair; radiation protection; guard duty and admission; alarm; fire protection; first aid. 4. Requirements to be met by part 2. Provisions and operational limitations; limit values important from the point of view of safety; normal operation; anomalous operation; in-service inspections. 6. Requirements to be met by part 3. 7. Annex: Rules, regulations and stipulations mentioned in the rule draft. (orig.)

  19. MetReS, an Efficient Database for Genomic Applications.

    Science.gov (United States)

    Vilaplana, Jordi; Alves, Rui; Solsona, Francesc; Mateo, Jordi; Teixidó, Ivan; Pifarré, Marc

    2018-02-01

    MetReS (Metabolic Reconstruction Server) is a genomic database that is shared between two software applications that address important biological problems. Biblio-MetReS is a data-mining tool that enables the reconstruction of molecular networks based on automated text-mining analysis of published scientific literature. Homol-MetReS allows functional (re)annotation of proteomes, to properly identify both the individual proteins involved in the processes of interest and their function. The main goal of this work was to identify the areas where the performance of the MetReS database performance could be improved and to test whether this improvement would scale to larger datasets and more complex types of analysis. The study was started with a relational database, MySQL, which is the current database server used by the applications. We also tested the performance of an alternative data-handling framework, Apache Hadoop. Hadoop is currently used for large-scale data processing. We found that this data handling framework is likely to greatly improve the efficiency of the MetReS applications as the dataset and the processing needs increase by several orders of magnitude, as expected to happen in the near future.

  20. Hydrogen storage capacity of titanium met-cars

    International Nuclear Information System (INIS)

    Akman, N; Durgun, E; Yildirim, T; Ciraci, S

    2006-01-01

    The adsorption of hydrogen molecules on the titanium metallocarbohedryne (met-car) cluster has been investigated by using the first-principles plane wave method. We have found that, while a single Ti atom at the corner can bind up to three hydrogen molecules, a single Ti atom on the surface of the cluster can bind only one hydrogen molecule. Accordingly, a Ti 8 C 12 met-car can bind up to 16 H 2 molecules and hence can be considered as a high-capacity hydrogen storage medium. Strong interaction between two met-car clusters leading to the dimer formation can affect H 2 storage capacity slightly. Increasing the storage capacity by directly inserting H 2 into the met-car or by functionalizing it with an Na atom have been explored. It is found that the insertion of neither an H 2 molecule nor an Na atom could further promote the H 2 storage capacity of a Ti 8 C 12 cluster. We have also tested the stability of the H 2 -adsorbed Ti 8 C 12 met-car with ab initio molecular dynamics calculations which have been carried out at room temperature

  1. Innovative Educational Practice: Using Virtual Labs in the Secondary Classroom

    Directory of Open Access Journals (Sweden)

    Marcel Satsky Kerr, PhD

    2004-07-01

    Full Text Available Two studies investigated the effectiveness of teaching science labs online to secondary students. Study 1 compared achievement among students instructed using hands-on Chemistry labs versus those instructed using virtual Chemistry labs (eLabs. Study 2 compared the same groups of students again while both teachers instructed using hands-on Chemistry labs to determine whether teacher or student characteristics may have affected Study 1’s findings. Participants were high school Chemistry students from a Central Texas Independent School District. Results indicated that: students learn science effectively online, schools may experience cost savings from delivering labs online, and students gain valuable technology skills needed later in college and in the workplace.

  2. JAVA Implementation of the Batched iLab Shared Architecture

    Directory of Open Access Journals (Sweden)

    Lenard Payne

    2013-04-01

    Full Text Available The MIT iLab Shared Architecture is limited currently to running on the Microsoft Windows platform. A JAVA implementation of the Batched iLab Shared Architecture has been developed that can be used on other operating systems and still interoperate with the existing Microsoft .NET web services of MIT’s iLab ServiceBroker. The Batched iLab Shared Architecture has been revised and separates the Labserver into a LabServer that handles experiment management and a LabEquipment that handles experiment execution. The JAVA implementation provides a 3-tier code development model that allows code to be reused and to develop only the code that is specific to each experiment.

  3. Dietary Patterns and Risk for Metabolic Syndrome in Korean Women: A Cross-Sectional Study.

    Science.gov (United States)

    Choi, Jeong-Hwa; Woo, Hae Dong; Lee, Jeong-Hee; Kim, Jeongseon

    2015-08-01

    Dietary patterns are a risk factor for metabolic syndrome (MetS). The prevalence of MetS has increased in Korea, and this condition has become a public health issue. Therefore, the present cross-sectional study aimed to identify the associations between dietary patterns and the risk of MetS among Korean women.The data of 5189 participants were analyzed to determine dietary intake and lifestyle. A principal components analysis was employed to determine participant dietary patterns with regard to 106 food items. MetS was diagnosed using the National Cholesterol Education Program, Adult Treatment Panel III. Logistic regression analyses were applied to evaluate the associations between dietary pattern quintiles and MetS and to generate odds ratios (ORs) and 95% confidence intervals (CIs) after adjusting for potential confounders.Three dietary patterns were identified: "traditional," "western," and "prudent." The "prudent" dietary pattern consisted of a high intake of fruits and fruit products as well as nuts, dairy, and a low consumption of grains; this pattern was negatively associated with the risk of MetS. The highest quintile of the "prudent" dietary pattern was significantly less likely to develop MetS (OR: 0.5, 95% CI: 0.36-0.68, P for trend traditional" and "western" dietary patterns were not associated with the risk of MetS.The "prudent" dietary pattern was negatively associated with the risk of developing MetS among Korean women.

  4. El acertijo de la metáfora visual

    OpenAIRE

    De la Rosa Alzate, Adriana; Universidad Autónoma de Occidente

    2016-01-01

    En este artículo se presentan los resultados de la investigación sobre el proceso de interpretación de la metáfora visual, en niños entre tres y cuatro años de edad. El propósito de la investigación fue dar cuenta del proceso de interpretación de la metáfora visual y del razonamiento involucrado. La metáfora visual se entiende como un fenómeno en el que los objetos representados presentan transformaciones que traen como consecuencia la emergencia de nuevas categorías e incluso la ambigüedad, ...

  5. Metáforas rígidas

    Directory of Open Access Journals (Sweden)

    González-Marín, Carmen

    1997-04-01

    Full Text Available No disponible.Las metáforas del tipo «Julieta es el sol» se interpretan normalmente como enunciados predicativos, y en consecuencia, como usos defectivos del lenguaje. Como tratamiento alternativo, analizamos el citado tipo de metáforas como enunciados que instauran una identidad entre dos objetos y no como enunciados que predican una semejanza o una defectiva pertenencia de un objeto a una clase dada. Las metáforas que responden a un esquema «a es (un b» son consideradas como parte de un enunciado que da cuenta de un estado intencional, o en otras palabras, como el alcance de un operador epistémico M, con la fuerza ilocucionaria de una declaración. Un trasfondo platónico justifica nuestra propuesta.

  6. Respecifying lab ethnography an ethnomethodological study of experimental physics

    CERN Document Server

    Sormani, Philippe

    2014-01-01

    Respecifying Lab Ethnography delivers the first ethnomethodological study of current experimental physics in action, describing the disciplinary orientation of lab work and exploring the discipline in its social order, formal stringency and skilful performance - in situ and in vivo. In bringing together two major strands of ethnomethodological inquiry, reflexive ethnography and video analysis, which have hitherto existed in parallel, Respecifying Lab Ethnography introduces a practice-based video analysis. In doing so, the book recasts conventional distinctions to shed fresh light on methodolog

  7. Evaluation of the Usability of Different Virtual Lab Software Used in Physics Courses

    Directory of Open Access Journals (Sweden)

    O. Karagoz

    2010-11-01

    Full Text Available In recent years the use of virtual lab software has become ubiquitous in education settings. The purpose of the current study is to de¬velop an Evaluation Scale to allow the easy and fast assessment of virtual lab software. During the development of the Evaluation Scale, theoretical and experimental studies investigating the effects of different software on learn¬ing, particularly in terms of usability, were utilized. The Evaluation Scale was created by adding new attributes to pre-existing scales, and comprises three sections – attributes related to the interface of the software; attributes related to its use as a material in education; and attributes related to product and ser¬vice support – and 79 items. Testing of the Evaluation Scale was carried out using two different virtual lab programmes, with the help of a checklist. The evaluation was carried out by physics teachers and academics that had previ¬ously used similar software, and consistency between the results was consid¬ered to represent inter-rater reliability. At the end of the study, the usability of the Evaluation Scale was tested, and the instructor evaluations regarding the usability characteristics considered sufficient and that require improvement in virtual lab software were also investigated.

  8. Remote monitoring of vacuum and valve status using LabVIEW

    International Nuclear Information System (INIS)

    Rozario, C.; Pal, S.; Nanal, V.; Pillay, R.G.

    2015-01-01

    For remote monitoring of vacuum status in LINAC and associated beam transport lines, a LabVIEW based interface through RS232 communication is developed. All vacuum stations in LINAC are equipped with Pfeiffer pressure measurement units, namely, TPQ 262 (for 2 no.s) and TPG256 (for 6 no.s). The communication to the unit is done via RS232 with the Serial Device Server. The electro-pneumatic gate valves separating beam line sections and cryostats are fitted with limit switches for indicating open/close status. A modular unit based on PIC 18F4520 microcontroller is developed to read the limit switch positions of up to 10 valves. Both the vacuum readout unit and the gate valve monitor unit act as a server to the client PC on the console. Each unit is assigned a unique IP address and connected to the TCP/IP Ethernet bus. The LabVIEW Virtual Instrument based TCP/IP is used for communication through the distributed LAN. It is possible to connect additional client PCs using the LabVIEW Remote Console features. During the accelerator operation the vacuum reading of the gauge and the status of valves can be monitored from the control room console. All the vacuum parameters like gauge value and status at different physical locations are scanned and logged approximately every second. The LabVIEW GUI has helped in making the system user friendly and can be expanded easily. (author)

  9. VR/IS Lab Virtual Actor research overview

    Energy Technology Data Exchange (ETDEWEB)

    Shawver, D.M.; Stansfield, S.

    1995-06-22

    This overview presents current research at Sandia National Laboratories in the Virtual Reality and Intelligent Simulation Lab. Into an existing distributed VR environment which we have been developing, and which provides shared immersion for multiple users, we are adding virtual actor support. The virtual actor support we are adding to this environment is intended to provide semi-autonomous actors, with oversight and high-level guiding control by a director/user, and to allow the overall action to be driven by a scenario. We present an overview of the environment into which our virtual actors will be added in Section 3, and discuss the direction of the Virtual Actor research itself in Section 4. We will briefly review related work in Section 2. First however we need to place the research in the context of what motivates it. The motivation for our construction of this environment, and the line of research associated with it, is based on a long-term program of providing support, through simulation, for situational training, by which we mean a type of training in which students learn to handle multiple situations or scenarios. In these situations, the student may encounter events ranging from the routine occurance to the rare emergency. Indeed, the appeal of such training systems is that they could allow the student to experience and develop effective responses for situations they would otherwise have no opportunity to practice, until they happened to encounter an actual occurance. Examples of the type of students for this kind of training would be security forces or emergency response forces. An example of the type of training scenario we would like to support is given in Section 4.2.

  10. Esiselkeytysaltaan lietepatjan hallinta Metsä-Board Kyrolla

    OpenAIRE

    Isokivijärvi, Jyri

    2016-01-01

    Metsä-Board Kyron kartonkitehtaan jätevesilaitoksella oli tarve saada tietoa esiselkeytysaltaan pohjalla olevasta lietepatjasta. Tiedon avulla haluttiin optimoida lietteenkäsittelyn toimintaa, säästää raaka-ainekustannuksissa ja estää esiselkeytysaltaan kaavintasillan liiallisesta kuormituksesta aiheutuva pysähtyminen. Aikaisemmin Metsä-Board Kyrolla pyrittiin pitämään lietepatja mahdollisimman vähissä, joka on johtanut siihen, että käyttökelpoista kuitupitoista paperi/kartonkimassaa on joudu...

  11. Stream piracy in the Black Hills: A geomorphology lab exercise

    Science.gov (United States)

    Zaprowski, B.J.; Evenson, E.B.; Epstein, J.B.

    2002-01-01

    The Black Hills of South Dakota exhibits many fine examples of stream piracy that are very suitable for teaching geomorphology lab exercises. This lab goes beyond standard topographic map interpretation by using geologic maps, well logs, gravel provenance and other types of data to teach students about stream piracy. Using a step-by-step method in which the lab exercises ramp up in difficulty, students hone their skills in deductive reasoning and data assimilation. The first exercises deal with the identification of stream piracy at a variety of spatial scales and the lab culminates with an exercise on landscape evolution and drainage rearrangement.

  12. The History of Science and Technology at Bell Labs

    Science.gov (United States)

    Bishop, David

    2008-03-01

    Over the last 80 years, Bell Labs has been one of the most scientifically and technologically productive research labs in the world. Inventions such as the transistor, laser, cell phone, solar cell, negative feedback amplifier, communications satellite and many others were made there. Scientific breakthroughs such as discovery of the Big Bang, the wave nature of the electron, electron localization and the fractional quantum hall effect were also made there making Bell Labs almost unique in terms of large impacts in both science and technology. In my talk, I will discuss the history of the lab, talk about the present and give some suggestions for how I see it evolving into the future.

  13. EarthLabs Meet Sister Corita Kent

    Science.gov (United States)

    Quartini, E.; Ellins, K. K.; Cavitte, M. G.; Thirumalai, K.; Ledley, T. S.; Haddad, N.; Lynds, S. E.

    2013-12-01

    The EarthLabs project provides a framework to enhance high school students' climate literacy and awareness of climate change. The project provides climate science curriculum and teacher professional development, followed by research on students' learning as teachers implement EarthLabs climate modules in the classroom. The professional development targets high school teachers whose professional growth is structured around exposure to current climate science research, data observation collection and analysis. During summer workshops in Texas and Mississippi, teachers work through the laboratories, experiments, and hand-on activities developed for their students. In summer 2013, three graduate students from the University of Texas at Austin Institute for Geophysics with expertise in climate science participated in two weeklong workshops. The graduate students partnered with exemplary teacher leaders to provide scientific content and lead the EarthLabs learning activities. As an experiment, we integrated a visit to the Blanton Museum and an associated activity in order to motivate participants to think creatively, as well as analytically, about science. This exercise was inspired by the work and educational philosophy of Sister Corita Kent. During the visit to the Blanton Museum, we steered participants towards specific works of art pre-selected to emphasize aspects of the climate of Texas and to draw participants' attention to ways in which artists convey different concepts. For example, artists use of color, lines, and symbols conjure emotional responses to imagery in the viewer. The second part of the exercise asked participants to choose a climate message and to convey this through a collage. We encouraged participants to combine their experience at the museum with examples of Sister Corita Kent's artwork. We gave them simple guidelines for the project based on techniques and teaching of Sister Corita Kent. Evaluation results reveal that participants enjoyed the

  14. Jefferson Lab's Journey into the Nucleus

    International Nuclear Information System (INIS)

    Douglas Higinbotham

    2004-01-01

    The year 1969 saw the publication of the first results indicating that hard scattering centres exist deep inside protons. A collaboration between the Stanford Linear Accelerator Center (SLAC) and the Massachusetts Institute of Technology was using SLAC's new high-energy electron LINAC to pioneer a rich new field in the study of the nucleus--deep inelastic scattering. Their measurements revealed that nucleons are made up of point-like particles, which Richard Feynman dubbed ''partons''. Thirty-five years on, studies of the parton-nature of the nucleus continue, not only at the traditional high-energy centres, but also at lower-energy laboratories, and in particular at the Thomas Jefferson National Accelerator Facility (Jefferson Lab) in Virginia. Jefferson Lab is home to the Continuous Electron Beam Accelerator Facility (CEBAF). Its main mission is to explore the atomic nucleus and the fundamental building-blocks of matter. As part of this mission, researchers there study the transition from the picture of the nucleus as a bound state of neutrons and protons to its deeper structure in terms of quarks and gluons--in other words, the transition from the hadronic degrees of freedom of nuclear physics to the quark-gluon degrees of freedom of high-energy physics. In exploring this transition, a wide range of experiments has been performed, from measurements of elastic form factors at large momentum transfers to studies of deep inelastic scattering. An array of spectrometers together with electron-beam energies of up to 5.7 GeV has allowed the laboratory to make significant contributions to this field. This article describes three experiments, each aimed at improving our understanding of a different aspect of the partonic nature of matter. The first, a classic deep inelastic scattering experiment, seeks to further our understanding of the composition of nucleon spin. The second experiment studies the concept of quark-hadron duality--a link between the deep inelastic

  15. RASPBERRY PI TIEDONKERUULAITTEENA : Case: Nab Labs Oy

    OpenAIRE

    Aho, Henri

    2016-01-01

    Opinnäytetyön aiheena oli Raspberry Pi-alustalle suunnitellun etäluettavan ja -hallittavan mittausjärjes-telmän toteuttaminen Nab Labs Oy:n ilmatutkimusyksikölle. Työn tavoitteena oli automatisoida mit-taustulosten keräämistä ja käsittelyä. Rinnakkain kulkeva teorian ja käytännön kuvaus jakaantuu kolmeen eri osa-alueeseen: Raspberry Pi ja siihen liitetyt laitteet, järjestelmän toiminta ja sen ohjelmointi sekä internet-käyttöliityntä ja www-ohjelmointi. Työn tuloksena syntyi mittalaitt...

  16. Innovation Incubator: Whisker Labs Technical Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Sparn, Bethany F. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Frank, Stephen M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Earle, Lieko [National Renewable Energy Lab. (NREL), Golden, CO (United States); Scheib, Jennifer G. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-08-01

    The Wells Fargo Innovation Incubator (IN2) is a program to foster and accelerate startup companies with commercial building energy-efficiency and demand management technologies. The program is funded by the Wells Fargo Foundation and co-administered by the National Renewable Energy Laboratory (NREL). Whisker Labs, an Oakland, California-based company, was one of four awardees in the first IN2 cohort and was invited to participate in the program because of its novel electrical power sensing technology for circuit breakers. The stick-on Whisker meters install directly on the front face of the circuit breakers in an electrical panel using adhesive, eliminating the need to open the panel and install current transducers (CTs) on the circuit wiring.

  17. Making the Case for Jefferson Lab

    International Nuclear Information System (INIS)

    This chapter is a personal account of the initial planning and competition for a new laboratory, which eventually became known as the Thomas Jefferson National Accelerator Facility, with the official nickname 'Jefferson Lab'. The period covered starts as far back as 1964, with the introduction of quarks, and extends up to the late 1980s after the initial team was assembled, the superconducting design was in place, and construction was well underway. I describe some of the major experiments that were proposed to justify the laboratory, reflect on the present status of those initially proposed experiments, and very briefly outline some of the new ideas that emerged after the laboratory was constructed. The science is presented in a simple manner intended for a lay audience, with some of the ideas illustrated by cartoons that were often used in popular lectures given during this period.

  18. The SPARC-LAB Thomson source

    Energy Technology Data Exchange (ETDEWEB)

    Vaccarezza, C., E-mail: cristina.vaccarezza@lnf.infn.it [INFN-LNF, Via Enrico Fermi, 40 00044 Frascati, Rome (Italy); Alesini, D.; Anania, M.P. [INFN-LNF, Via Enrico Fermi, 40 00044 Frascati, Rome (Italy); Bacci, A. [INFN-MI, Via Celoria 16, 20133 Milan (Italy); Biagioni, A.; Bisesto, F.; Bellaveglia, M. [INFN-LNF, Via Enrico Fermi, 40 00044 Frascati, Rome (Italy); Cardarelli, P. [University of Ferrara and INFN-FE, via Saragat 1, 44122 Ferrara (Italy); Cardelli, F. [University La Sapienza and INFN-Roma1, Piazzale Aldo Moro, 2 00161 Rome (Italy); Cianchi, A. [University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome (Italy); Chiadroni, E.; Croia, M.; Curcio, A. [INFN-LNF, Via Enrico Fermi, 40 00044 Frascati, Rome (Italy); Delogu, P. [University of Pisa and INFN-PI, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Giovenale, D. Di [INFN-LNF, Via Enrico Fermi, 40 00044 Frascati, Rome (Italy); Domenico, G. Di [University of Ferrara and INFN-FE, via Saragat 1, 44122 Ferrara (Italy); Pirro, G. Di [INFN-LNF, Via Enrico Fermi, 40 00044 Frascati, Rome (Italy); Drebot, I. [INFN-MI, Via Celoria 16, 20133 Milan (Italy); Ferrario, M. [INFN-LNF, Via Enrico Fermi, 40 00044 Frascati, Rome (Italy); Filippi, F. [University La Sapienza and INFN-Roma1, Piazzale Aldo Moro, 2 00161 Rome (Italy); and others

    2016-09-01

    The SPARC-LAB Thomson source is a compact X-ray source based on the Thomson backscattering process presently under its second phase of commissioning at the LNF. The electron beam energy ranges between 30 and 150 MeV, the electrons collide head-on with the Ti:Sapphire FLAME laser pulse the energy of which ranges between 1 and 5 J with pulse lengths in the 25 fs–10 ps range, this provides an X-ray energy tunability in the range of 20–500 keV, with the further capability to generate strongly non-linear phenomena and to drive diffusion processes due to multiple and plural scattering effects. The experimental results of the obtained X-ray radiation are presented.

  19. Replacing textbook problems with lab experiences

    Science.gov (United States)

    Register, Trevor

    2017-10-01

    End-of-the-chapter textbook problems are often the bread and butter of any traditional physics classroom. However, research strongly suggests that students be given the opportunity to apply their knowledge in multiple contexts as well as be provided with opportunities to do the process of science through laboratory experiences. Little correlation has been shown linking the number of textbook problems solved with conceptual understanding of topics in mechanics. Furthermore, textbook problems as the primary source of practice for students robs them of the joy and productive struggle of learning how to think like an experimental physicist. Methods such as Modeling Instruction tackle this problem head-on by starting each instructional unit with an inquiry-based lab aimed at establishing the important concepts and equations for the unit, and this article will discuss ideas and experiences for how to carry that philosophy throughout a unit.

  20. Making the Case for Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    Gross, Franz

    2011-06-01

    This chapter is a personal account of the initial planning and competition for a new laboratory, which eventually became known as the Thomas Jefferson National Accelerator Facility, with the official nickname "Jefferson Lab." The period covered starts as far back as 1964, with the introduction of quarks, and extends up to the late 1980s after the initial team was assembled, the superconducting design was in place, and construction was well underway. I describe some of the major experiments that were proposed to justify the laboratory, reflect on the present status of those initially proposed experiments, and very briefly outline some of the new ideas that emerged after the laboratory was constructed. The science is presented in a simple manner intended for a lay audience, with some of the ideas illustrated by cartoons that were often used in popular lectures given during this period.

  1. The Jefferson Lab Frozen Spin Target

    Energy Technology Data Exchange (ETDEWEB)

    Christopher Keith, James Brock, Christopher Carlin, Sara Comer, David Kashy, Josephine McAndrew, David Meekins, Eugene Pasyuk, Joshua Pierce, Mikell Seely

    2012-08-01

    A frozen spin polarized target, constructed at Jefferson Lab for use inside a large acceptance spectrometer, is described. The target has been utilized for photoproduction measurements with polarized tagged photons of both longitudinal and circular polarization. Protons in TEMPO-doped butanol were dynamically polarized to approximately 90% outside the spectrometer at 5 T and 200-300 mK. Photoproduction data were acquired with the target inside the spectrometer at a frozen-spin temperature of approximately 30 mK with the polarization maintained by a thin, superconducting coil installed inside the target cryostat. A 0.56 T solenoid was used for longitudinal target polarization and a 0.50 T dipole for transverse polarization. Spin relaxation times as high as 4000 hours were observed. We also report polarization results for deuterated propanediol doped with the trityl radical OX063.

  2. VPPD Lab - The Chemical Product Simulator

    DEFF Research Database (Denmark)

    Kalakul, Sawitree; Hussain, Rehan; Elbashir, Nimir

    2015-01-01

    of product performance models and product-chemical property models are used to evaluate different classes of product. The product classes are single molecular structure chemicals (lipids, solvents, aroma, etc.), blended products (gasoline, jet-fuels, lubricants, etc.), and emulsified product (hand wash......In this paper, the development of a systematic model-based framework for product design, implemented in the new product design software called VPPD-Lab is presented. This framework employs its in-house knowledge-based system to design and evaluate chemical products. The built-in libraries......, detergent, etc.). It has interface to identify workflow/data-flow for the inter-related activities between knowledge-based system and model-based calculation procedures to systematically, efficiently and robustly solve various types of product design-analysis problems. The application of the software...

  3. Tough Times Ahead for Government Labs

    International Nuclear Information System (INIS)

    Ban, Stephen; Buchanan, Michelle V.; Cheeks, Nona; Funsten, Herbert; Hawsey, Robert; Lane, Monya; Whitlow, Woodrow Jr.; Studt, Tim

    2008-01-01

    Many government R and D laboratory executives face a tough couple of months ahead. These anxieties are fueled by (1) possible management, technical direction, and budgetary changes in their agencies due to changes in the federal administration; (2) frozen operating budgets until March 2009 due to the Continuing Resolution (CR) attachment to the recent banking bailout bill; and (3) the financial fallout from the economic downturn. These and other pertinent questions regarding their R and D operations were addressed in R and D Magazine's 9th Annual Government R and D Executive Roundtable held on Oct. 16, 2008, in conjunction with the 46th Annual R and D 100 Awards at Chicago's Navy Pier. Most members of this year's government executive panel were hesitant to speculate on the changes that might occur in their labs as a result of the new administration. The exception to this stand was the National Renewable Energy Laboratory's (NREL's) Robert Hawsey. ''No matter who wins (the Roundtable was held before the Nov. 4th Presidential election), we expect to see continued support,'' says Hawsey. ''All of our cooperative research facilities are over-subscribed and we're looking at how we can expand them.'' Obviously, renewable energy is a hot button in the administration and likely to get increased financial backing to help meet our country's energy independence goals. When pressed, the panel was mostly optimistic about their future support, stating that external threats to the U.S. have not changed, and research work associated with homeland security and national defense is unlikely to see drastic change. ''We have a strong portfolio in life science and don't expect any changes,'' says Oak Ridge National Laboratory's (ORNL's) Michelle Buchanan. Ongoing federally funded work at the national labs that was started before the Oct. 1st start of the FY2009 fiscal year will continue without any changes - those funds are unaffected by the CR action. This applies as well to any

  4. Characterization of Tri-lab Tantalum Plate.

    Energy Technology Data Exchange (ETDEWEB)

    Buchheit, Thomas E.; Cerreta, Ellen K.; Deibler, Lisa Anne; Chen, Shu-Rong; Michael, Joseph R.

    2014-09-01

    This report provides a detailed characterization Tri-lab Tantalum (Ta) plate jointly purchased from HCStark Inc. by Sandia, Los Alamos and Lawrence Livermore National Laboratories. Data in this report was compiled from series of material and properties characterization experiments carried out at Sandia (SNL) and Los Alamos (LANL) Laboratories through a leveraged effort funded by the C2 campaign. Results include microstructure characterization detailing the crystallographic texture of the material and an increase in grain size near the end of the rolled plate. Mechanical properties evaluations include, compression cylinder, sub-scale tension specimen, micohardness and instrumented indentation testing. The plate was found to have vastly superior uniformity when compare with previously characterized wrought Ta material. Small but measurable variations in microstructure and properties were noted at the end, and at the top and bottom edges of the plate.

  5. Cesarean Section

    Science.gov (United States)

    A Cesarean section (C-section) is surgery to deliver a baby. The baby is taken out through the mother's ... are able to have a vaginal birth after cesarean (VBAC). NIH: National Institute of Child Health and ...

  6. The Jefferson Lab High Power Light Source

    International Nuclear Information System (INIS)

    Jefferson Lab has designed, built and operated two high average power free-electron lasers (FEL) using superconducting RF (SRF) technology and energy recovery techniques. Between 1999-2001 Jefferson Lab operated the IR Demo FEL. This device produced over 2 kW in the mid-infrared, in addition to producing world record average powers in the visible (50 W), ultraviolet (10 W) and terahertz range (50 W) for tunable, short-pulse (< ps) light. This FEL was the first high power demonstration of an accelerator configuration that is being exploited for a number of new accelerator-driven light source facilities that are currently under design or construction. The driver accelerator for the IR Demo FEL uses an Energy Recovered Linac (ERL) configuration that improves the energy efficiency and lowers both the capital and operating cost of such devices by recovering most of the power in the spent electron beam after optical power is extracted from the beam. The IR Demo FEL was de-commissioned in late 2001 for an upgraded FEL for extending the IR power to over 10 kW and the ultraviolet power to over 1 kW. The FEL Upgrade achieved 10 kW of average power in the mid-IR (6 microns) in July of 2004, and its IR operation currently is being extended down to 1 micron. In addition, we have demonstrated the capability of on/off cycling and recovering over a megawatt of electron beam power without diminishing machine performance. A complementary UV FEL will come on-line within the next year. This paper presents a summary of the FEL characteristics, user community accomplishments with the IR Demo, and planned user experiments

  7. The Jefferson Lab High Power Light Source

    Energy Technology Data Exchange (ETDEWEB)

    James R. Boyce

    2006-01-01

    Jefferson Lab has designed, built and operated two high average power free-electron lasers (FEL) using superconducting RF (SRF) technology and energy recovery techniques. Between 1999-2001 Jefferson Lab operated the IR Demo FEL. This device produced over 2 kW in the mid-infrared, in addition to producing world record average powers in the visible (50 W), ultraviolet (10 W) and terahertz range (50 W) for tunable, short-pulse (< ps) light. This FEL was the first high power demonstration of an accelerator configuration that is being exploited for a number of new accelerator-driven light source facilities that are currently under design or construction. The driver accelerator for the IR Demo FEL uses an Energy Recovered Linac (ERL) configuration that improves the energy efficiency and lowers both the capital and operating cost of such devices by recovering most of the power in the spent electron beam after optical power is extracted from the beam. The IR Demo FEL was de-commissioned in late 2001 for an upgraded FEL for extending the IR power to over 10 kW and the ultraviolet power to over 1 kW. The FEL Upgrade achieved 10 kW of average power in the mid-IR (6 microns) in July of 2004, and its IR operation currently is being extended down to 1 micron. In addition, we have demonstrated the capability of on/off cycling and recovering over a megawatt of electron beam power without diminishing machine performance. A complementary UV FEL will come on-line within the next year. This paper presents a summary of the FEL characteristics, user community accomplishments with the IR Demo, and planned user experiments.

  8. LAB bacteriocin applications in the last decade

    Directory of Open Access Journals (Sweden)

    Ma. del Rocío López-Cuellar

    2016-11-01

    Full Text Available In the early 2000s, the expectations about bacteriocins produced by lactic acid bacteria (LABs were aimed at food applications. However, the effectiveness of bacteriocins against undesirable micro-organisms opened endless possibilities for innovative research. In the present review, we collected a database including 429 published papers and 245 granted patents (from 2004 to 2015. Based on bibliometric analysis, the progress of bacteriocin research in the last 11 years was discussed in detail. It was found that 164 patents were granted in 2010–2015, which is equivalent to 60% in comparison with previous years (i.e. only 81 patents were granted in 2004–2009. Currently, the research on bacteriocins is still gaining importance. In the realm of therapeutic strategies, about a 37% of the published research was focused on biomedical applications in the last decade. This vein of research is currently seeking for alternative solutions to problems such as cancer, systemic infections, oral-care, vaginal infections, contraception and skincare. On the other hand, food preservation, bio-nanomaterial and veterinary applications represent 29%, 25% and 9%, respectively. All this technology is being applied and will surely grow in the future, since about 31% of the patents granted since 2004 are focused on the biomedical area, 29% on food preservation, 5% on veterinary use; whereas 13% and 16% correspond to patents granted on production–purification systems and recombinant proteins or molecular modifications in the producer strains. This review contributes to the analysis of recent LAB bacteriocin applications and their role in safety, quality and improvement of human health.

  9. Lab-on a-Chip

    Science.gov (United States)

    1999-01-01

    Labs on chips are manufactured in many shapes and sizes and can be used for numerous applications, from medical tests to water quality monitoring to detecting the signatures of life on other planets. The eight holes on this chip are actually ports that can be filled with fluids or chemicals. Tiny valves control the chemical processes by mixing fluids that move in the tiny channels that look like lines, connecting the ports. Scientists at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama designed this chip to grow biological crystals on the International Space Station (ISS). Through this research, they discovered that this technology is ideally suited for solving the challenges of the Vision for Space Exploration. For example, thousands of chips the size of dimes could be loaded on a Martian rover looking for biosignatures of past or present life. Other types of chips could be placed in handheld devices used to monitor microbes in water or to quickly conduct medical tests on astronauts. The portable, handheld Lab-on-a Chip Application Development Portable Test System (LOCAD-PTS) made its debut flight aboard Discovery during the STS-116 mission launched December 9, 2006. The system allowed crew members to monitor their environment for problematic contaminants such as yeast, mold, and even E.coli, and salmonella. Once LOCAD-PTS reached the ISS, the Marshall team continued to manage the experiment, monitoring the study from a console in the Payload Operations Center at MSFC. The results of these studies will help NASA researchers refine the technology for future Moon and Mars missions. (NASA/MSFC/D.Stoffer)

  10. Serum vitamin d levels and the components of metabolic syndrome: an analytical cross-sectional study

    International Nuclear Information System (INIS)

    Roomi, M.A.; Farooq, A.; Ullah, E.; Lone, K.P.

    2015-01-01

    The present study was planned to determine the serum vitamin D levels and its relation with the various components of metabolic syndrome (MetS) in MetS positive and MetS negative subjects. Methods: This analytical cross-sectional study on 88 subjects who were divided into two groups based on whether they fulfill the diagnostic criteria for MetS or not. Fasting serum glucose, lipid profile, insulin, HOMA-IR and vitamin D levels were measured. Two sample-t test and Mann-Whitney U tests were used to compare the differences. Pearson and Spearman correlation tests were used to observe the correlations. Results: BMI (p=0.001), waist/hip ratio (p=0.001), systolic blood pressure (p=0.010), diastolic blood pressure (p=0.010), fasting serum TGs (p = 0.001), TG/HDL ratio (p=0.001), fasting blood sugar (p=0.010), fasting serum insulin (p = 0.001) and HOMA-IR (p=0.001) were significantly high in MetS positive than MetS negative subjects. In MetS Positive subjects, serum vitamin D levels were found to have negative correlation with serum LDL (r= -0.485, p=0.001), total cholesterol (r= -0.408, p=0.007) and total cholesterol/HDL ratio (r= -0.355, p=0.019). Moreover, serum vitamin D levels were found to have positive correlation with HDL/LDL ratio (r= 0.443, p=0.003). Other components of MetS did not show significant correlation with serum vitamin D levels in MetS positive subjects. In MetS negative subjects, serum vitamin D levels did not show any significant correlation with any of the study parameters. Conclusions: Serum vitamin D levels were correlated with a number of MetS components which may be controlled by optimizing vitamin D levels. (author)

  11. Las metáforas de comunicación como metáforas que cobran realidad

    OpenAIRE

    Meunier, Jean Pierrer; Université catholique de Louvain

    1997-01-01

    En el paisaje teórico relativo a la comunicación, la noción de metáfora parece manifestarse y producir efectos en todas las dimensiones de la comunicación que sucesivamente se dan en el campo de la investigación: la significación, la relación, la cognición. La metáfora se presenta a la vez como un concepto iluminador y un concepto apra iluminar, como un concepto capaz de esclarecer toda clase de relaciones concretas de comunicación.

  12. Reducing unnecessary lab testing in the ICU with artificial intelligence.

    Science.gov (United States)

    Cismondi, F; Celi, L A; Fialho, A S; Vieira, S M; Reti, S R; Sousa, J M C; Finkelstein, S N

    2013-05-01

    To reduce unnecessary lab testing by predicting when a proposed future lab test is likely to contribute information gain and thereby influence clinical management in patients with gastrointestinal bleeding. Recent studies have demonstrated that frequent laboratory testing does not necessarily relate to better outcomes. Data preprocessing, feature selection, and classification were performed and an artificial intelligence tool, fuzzy modeling, was used to identify lab tests that do not contribute an information gain. There were 11 input variables in total. Ten of these were derived from bedside monitor trends heart rate, oxygen saturation, respiratory rate, temperature, blood pressure, and urine collections, as well as infusion products and transfusions. The final input variable was a previous value from one of the eight lab tests being predicted: calcium, PTT, hematocrit, fibrinogen, lactate, platelets, INR and hemoglobin. The outcome for each test was a binary framework defining whether a test result contributed information gain or not. Predictive modeling was applied to recognize unnecessary lab tests in a real world ICU database extract comprising 746 patients with gastrointestinal bleeding. Classification accuracy of necessary and unnecessary lab tests of greater than 80% was achieved for all eight lab tests. Sensitivity and specificity were satisfactory for all the outcomes. An average reduction of 50% of the lab tests was obtained. This is an improvement from previously reported similar studies with average performance 37% by [1-3]. Reducing frequent lab testing and the potential clinical and financial implications are an important issue in intensive care. In this work we present an artificial intelligence method to predict the benefit of proposed future laboratory tests. Using ICU data from 746 patients with gastrointestinal bleeding, and eleven measurements, we demonstrate high accuracy in predicting the likely information to be gained from proposed future

  13. Reducing unnecessary lab testing in the ICU with artificial intelligence

    Science.gov (United States)

    Cismondi, F.; Celi, L.A.; Fialho, A.S.; Vieira, S.M.; Reti, S.R.; Sousa, J.M.C.; Finkelstein, S.N.

    2017-01-01

    Objectives To reduce unnecessary lab testing by predicting when a proposed future lab test is likely to contribute information gain and thereby influence clinical management in patients with gastrointestinal bleeding. Recent studies have demonstrated that frequent laboratory testing does not necessarily relate to better outcomes. Design Data preprocessing, feature selection, and classification were performed and an artificial intelligence tool, fuzzy modeling, was used to identify lab tests that do not contribute an information gain. There were 11 input variables in total. Ten of these were derived from bedside monitor trends heart rate, oxygen saturation, respiratory rate, temperature, blood pressure, and urine collections, as well as infusion products and transfusions. The final input variable was a previous value from one of the eight lab tests being predicted: calcium, PTT, hematocrit, fibrinogen, lactate, platelets, INR and hemoglobin. The outcome for each test was a binary framework defining whether a test result contributed information gain or not. Patients Predictive modeling was applied to recognize unnecessary lab tests in a real world ICU database extract comprising 746 patients with gastrointestinal bleeding. Main results Classification accuracy of necessary and unnecessary lab tests of greater than 80% was achieved for all eight lab tests. Sensitivity and specificity were satisfactory for all the outcomes. An average reduction of 50% of the lab tests was obtained. This is an improvement from previously reported similar studies with average performance 37% by [1–3]. Conclusions Reducing frequent lab testing and the potential clinical and financial implications are an important issue in intensive care. In this work we present an artificial intelligence method to predict the benefit of proposed future laboratory tests. Using ICU data from 746 patients with gastrointestinal bleeding, and eleven measurements, we demonstrate high accuracy in predicting the

  14. Vakansiehuis met swembad. Herman Koch. Vertaal deur Daniel ...

    African Journals Online (AJOL)

    - tig minuten (“my verkoopspunt”), maar. “[p]asiënte verwar tyd met aandag”. Marc luistert niet echt, want een huisarts. “hoef mense nie gesond te maak nie” (12). En als ze zich niet laten afschepen, doet hij maar een rectaal touché, want “hulle.

  15. Permanent dysphagia in familial amyloid polyneuropathy (ATTRVal30Met).

    Science.gov (United States)

    Monteiro, Cecília; Magalhães, Marina; Correia, Carlos; Taipa, Ricardo

    2012-06-01

    Gastrointestinal symptoms are frequent in familial amyloid polyneuropathy, mainly resulting from autonomic nervous system involvement. Dysphagia is one of the possible symptoms, although rarely severe or sudden. We describe a case of a sudden onset and severe dysphagia, a rare form of presentation, in a patient whose polyneuropathy was still beeing investigated and turned out to be ATTRVal30Met-polyneuropathy.

  16. De overeenkomst van internet service providers met consumenten

    NARCIS (Netherlands)

    Siemerink, Leonie Anna Rika

    2007-01-01

    Dit boek schetst het juridisch kader voor overeenkomsten van Internet Service Providers (ISP’s) met consumenten. Daartoe is ondermeer een analyse gemaakt van de inhoud van algemene voorwaarden die verschillende ISP’s hanteren.Wat regelen de ISP’s in hun algemene voorwaarden en wat zijn de

  17. Beoordeling gezondheidsrisico's door sporten op kunstgrasvelden met rubbergranulaat

    NARCIS (Netherlands)

    Oomen AG; de Groot GM; CPV; M&V

    2016-01-01

    Uit nieuw onderzoek van het RIVM blijkt dat het risico voor de gezondheid van sporten op kunstgrasvelden die zijn ingestrooid met rubbergranulaat, praktisch verwaarloosbaar is. Dat betekent dat het verantwoord is om op deze velden te sporten. Aanleiding voor het onderzoek is de maatschappelijke

  18. Ontsmetten met Easy Ice Clean ("Coldblast") "Proof of principle"

    NARCIS (Netherlands)

    Ludeking, D.J.W.; Hamelink, R.; Gulik, van M.W.; Diepenhorst, T.

    2012-01-01

    In dit onderzoek is er gekeken naar de potentie en het proof of principle van de Cold Jet techniek van Easy Ice Clean in de tuinbouw. Met dit onderzoek is getracht te beantwoorden of de Cold Jet techniek potentie heeft als alternatieve ontsmettingstechniek voor chemische middelen. De techniek die in

  19. Aanvullend radiumonderzoek op twee met woningen bebouwde havenspeciepolders

    NARCIS (Netherlands)

    Stoop P; Hiemstra YS; Lembrechts JFMM; LSO

    1995-01-01

    Dit rapport beschrijft een onderzoek naar radiumgehalten dat uitgevoerd is voor de locaties Steendijkpolder-zuid, Maassluis (STPZ) en Woudhoek-noord, Schiedam (WH). Het doel van het onderzoek is, voor een met havenspecie opgespoten polder zonder afdeklaag (STPZ), te bepalen of de variatie in het

  20. Een adolescente jongen met fibreuze dysplasie van het kaakbot

    NARCIS (Netherlands)

    Nieuwland, A.C.; Vierhout, I.; Eekhoff, E.M.W.; van der Waal, I.

    2012-01-01

    Een 16-jarige jongen bleek na diagnostisch onderzoek met computertomografie en een skeletscan de monostotische verschijningsvorm van fibreuze dysplasie in de maxilla te hebben. De diagnose is bevestigd aan de hand van een botbiopt. Tijdens een periode van 8 jaar afwachtend beleid hebben zich geen

  1. Klaverbank Survey met de ARCA 17‐21 Nov 2014

    NARCIS (Netherlands)

    Lavaleye, M.

    2014-01-01

    Op Maandag 17 Nov 2014 vertrok de ARCA om 9:00 van uit de haven van Scheveningen richting Klaverbank. Het weer was bijzonder mooi en rustig, uitzonderlijk voor deze tijd van het jaar. Om 19:00 werd de Klaverbank bereikt, en werd gelijk begonnen met de Multibeam en side scan sonar raaien (Fig. 1).

  2. Liturgiese klere met besondere verwysing na die Nederduitsch ...

    African Journals Online (AJOL)

    koorrok 'n mantel en 'n bef gedra het. In Suid-Afrika was daar aanvanklik nie sprake van ampsdrag nie (SKLAS 1987: 9). Uit sketse en foto's is dit egter duidelik dat predikante en reg.sgeleerdes oral in die alledaagse deftige drag met toga of mantel en bef gekleed gegaan het. Sommige foto's toon predikante uit die agtiende ...

  3. Christus' offer bij Paulus vergeleken met de offeropvattingen van Philo

    NARCIS (Netherlands)

    Stelma, Juurd Hari

    1938-01-01

    Een vergelijking der offeropvattingen van Paulus en Philo brengt ons in aanraking met twee principieel verschillende voorstellingen aangaande het offer. Het offer van Christus is voor Paulus de gave Gods, waardoor de macht van de zonde en dood vernietigd en de schuld verzoend is. Door de

  4. 'Epistemology models ontology'− In gesprek met John Polkinghorne

    African Journals Online (AJOL)

    Test

    7 Jun 2011 ... en wel aan die hand van John Polkinghorne2, 'n ander laureatus en wat verlede jaar 80 jaar oud geword het en spesifiek met die onderhawige kwessie dekades lank reeds ... Triniteitsleer word dus 'n heuristiese instrument om die natuur te verstaan: 'we know the economic quark but not the immanent ...

  5. Die hervertolking van die paradigma in verband met die ...

    African Journals Online (AJOL)

    Die hervertolking van die paradigma in verband met die Kollegialisme om die. Afrikaanse kerke kerkregtelik te verstaan. E Brown. Universiteit van Stellenbosch. Abstract. Reinterpreting the paradigm concerning 'Kollegialisme' in order to understand the Afrikaans churches accoring to church law. The Afrikaans term ...

  6. Voedingsnavorsing met die weidende dier | Engels | South African ...

    African Journals Online (AJOL)

    South African Journal of Animal Science. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 13, No 4 (1983) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Voedingsnavorsing met die weidende dier.

  7. Tweetalig onderwijs met vervroegd Engels in het basisonderwijs

    NARCIS (Netherlands)

    Aarts, R.; Ronde, S.

    2006-01-01

    In dit artikel wordt verslag gedaan van een explortief onderzoek naar het functioneren van een tweetalig onderwijsprogramma waarin (naast het Nederlands) Engels aangeboden wordt in de onderbouw van het basisonderwijs. De resultaten laten zien dat de betrokkenen positieve ervaringen met en hoge

  8. DYNAMIND: Naar dynamisch en gestructureerd vraaggestuurd leren met digitaal mindmappen

    NARCIS (Netherlands)

    Harry Stokhof; Haske van Vlokhoven; Martijn Peters; Dominique Sluijsmans

    2011-01-01

    Werken met papieren mindmaps lijkt echter nog onvoldoende uit te nodigen tot het herzien en herschikken van conceptuele verbanden (Stokhof, De Vries 2009). Mindmapping via meer dynamische tools lijkt dit meer mogelijk te maken. In dit quasi-experimentele exploratieve onderzoek worden twee vragen

  9. Evidence-based doceren in het hoger onderwijs met ICT

    NARCIS (Netherlands)

    Van den Berg, Ellen; Kirschner, Paul A.

    2013-01-01

    Van den Berg, E., & Kirschner, P. A. (2012). Evidence-based doceren in het hoger onderwijs met ICT [Evidence based teaching in higher education with ICT]. In L. A. Plugge (Ed.), WTR Trendrapport 2012 De Bakens verzetten (pp. 1-10). Utrecht, Nederland: Stichting SURF.

  10. Zuivering brouwerijprocesafvalwater met behulp van microalgen: Resultaten onderzoek 2012

    NARCIS (Netherlands)

    Dijk, van W.; Schipperus, R.; Grobben, S.A.; Weide, van der R.Y.

    2013-01-01

    In een samenwerkingsverband van Heineken Nederland BV, Algae Food & Fuel en WUR (Acrres) is in 2012 een onderzoeksproject gestart om de mogelijkheden van zuivering van procesafvalwater van de brouwerijen met behulp van algen te onderzoeken. In het kader van dit project is in 2012 een

  11. Een bepalingsmethode voor thallium in regenwater met behulp van voltammetrie

    NARCIS (Netherlands)

    Struijs; J.; Wolfs; P.M.; Esseveld; F.G.van

    1985-01-01

    In dit rapport wordt een bepalingmethode beschreven voor thallium in het nanogram/liter-gebied, waarbij gebruik wordt gemaakt van differentiele pulse-anodic stripping voltammetry (DPASV) aan de dunne kwikfilm. Met deze techniek blijkt het mogelijk om de concentratie van dit element rechtstreeks

  12. Consumentenpanel Gezondheidszorg: basisrapport met informatie over het panel .

    NARCIS (Netherlands)

    Brabers, A.E.M.; Reitsma-van Rooijen, M.; Jong, J.D. de

    2012-01-01

    Het NIVEL is onlangs gestart met de werving van 1.000 migranten voor het Consumentenpanel Gezondheidszorg. In het panel worden landelijk meningen en ervaringen verzameld van gebruikers van de gezondheidszorg. De panelleden moeten daarom een goede afspiegeling vormen van de bevolking. Het panel

  13. Consumentenpanel Gezondheidszorg: basisrapport met informatie over het panel, 2009.

    NARCIS (Netherlands)

    Reitsma-van Rooijen, M.; Jong, J.D. de

    2009-01-01

    Wat vinden we van de gezondheidszorg? Wat weten we ervan en wat zijn onze verwachtingen en ervaringen? Het NIVEL vindt een antwoord op dit soort vragen met het Consumentenpanel Gezondheidszorg, waarover nu een basisrapport is verschenen. De gezondheidszorg gaat iedereen aan. Het Consumentenpanel

  14. Testen van stoffen met een mogelijk afwerende werking op trips

    NARCIS (Netherlands)

    Pijnakker, J.; Leman, A.

    2014-01-01

    Secundaire plantenstoffen, zoals essentiële oliën, hebben het vermogen om te interfereren met het selectieproces van een geschikte waardplant door een plaaginsect. In het eerste gedeelte van dit verslag worden de resultaten beschreven van laboratorium- en kasproeven waarin een aantal mogelijk

  15. MetAssimulo:Simulation of Realistic NMR Metabolic Profiles

    Directory of Open Access Journals (Sweden)

    De Iorio Maria

    2010-10-01

    Full Text Available Abstract Background Probing the complex fusion of genetic and environmental interactions, metabolic profiling (or metabolomics/metabonomics, the study of small molecules involved in metabolic reactions, is a rapidly expanding 'omics' field. A major technique for capturing metabolite data is 1H-NMR spectroscopy and this yields highly complex profiles that require sophisticated statistical analysis methods. However, experimental data is difficult to control and expensive to obtain. Thus data simulation is a productive route to aid algorithm development. Results MetAssimulo is a MATLAB-based package that has been developed to simulate 1H-NMR spectra of complex mixtures such as metabolic profiles. Drawing data from a metabolite standard spectral database in conjunction with concentration information input by the user or constructed automatically from the Human Metabolome Database, MetAssimulo is able to create realistic metabolic profiles containing large numbers of metabolites with a range of user-defined properties. Current features include the simulation of two groups ('case' and 'control' specified by means and standard deviations of concentrations for each metabolite. The software enables addition of spectral noise with a realistic autocorrelation structure at user controllable levels. A crucial feature of the algorithm is its ability to simulate both intra- and inter-metabolite correlations, the analysis of which is fundamental to many techniques in the field. Further, MetAssimulo is able to simulate shifts in NMR peak positions that result from matrix effects such as pH differences which are often observed in metabolic NMR spectra and pose serious challenges for statistical algorithms. Conclusions No other software is currently able to simulate NMR metabolic profiles with such complexity and flexibility. This paper describes the algorithm behind MetAssimulo and demonstrates how it can be used to simulate realistic NMR metabolic profiles with

  16. Sociale economie en de lokale overheid : samenwerken met sociale ondernemers als strategie bij werkgelegenheidsbeleid

    NARCIS (Netherlands)

    Smit, A.; Fermin, B.; Penninga, M.; Andriessen, S.

    2007-01-01

    Deze uitgave, vooral bestemd voor gemeenten, gaat over sociale economie en samenwerken met sociale ondernemingen. Sociale ondernemingen zijn bedrijven met een dubbele doelstelling, economisch én sociaal. Gemeenten kunnen met deze bedrijven samenwerken vanuit publieke doelstellingen, zoals activering

  17. Metabolic syndrome among adults of surendranagar District of Saurashtra, Gujarat: A cross-sectional Study

    Directory of Open Access Journals (Sweden)

    Chaitanya Gopalrao Chinawale

    2018-01-01

    Full Text Available Background: The metabolic syndrome (MetS is a complex disorder and a major health concern in developing countries. Data on MetS in Indian population show multiplicity. There are no published reports about the prevalence of MetS in population of Saurashtra region, Gujarat. The aim of this study is to assess the prevalence of MetS and its components in adult population of this region. Methods: This cross-sectional observational study was carried out among 473 participants who attended free health checkup camps. Demographics, personal details along with anthropometric, clinical, and biochemical data were recorded. The MetS was diagnosed as per the definition provided by Joint Interim Statement 2009. Results: The overall prevalence of MetS among studied population was found to be 41.01% (females 44.21% and males 37.91%. Abdominal obesity (66.38%, low high-density lipoprotein-cholesterol (64.69%, and high blood pressure (40.59% appeared as the most prevalent components. MetS showed a significant association with age, body mass index, total cholesterol, habit of chewing tobacco, and history of hypertension and hyperglycemia. Conclusion: The high prevalence of MetS shows that population of Saurashtra is at an increased risk of cardiovascular disease (CVD and diabetes. This highlights the need for extensive diabetes and CVD prevention and control program in this region.

  18. Ontology: A Support Structure for a V-Labs Network: Euronet-Lab

    Directory of Open Access Journals (Sweden)

    Raul Cordeiro Correia

    2012-11-01

    Full Text Available Our propose is to build a network of virtual laboratories, based in a Virtual Closet that will contain all the elements and parts that are needed to build the various experiences available in a v-labs network (that we call Euronet-Lab. To build this complex network we need to find a system that supports effectively this structure. This probably will be a enormous database of v-labs and independent elements, where will be possible sometimes to “recycle” some of the elements. This means “re-use” the same element several times in many experiences. To do this is necessary to have a structure that allows us to have several instances of the same element. It’s important that in our structure and virtual environment we can create several “images” of the same reality and this images can be used simultaneously in different circuits/experiments. This means that we can create several instances of the same element, to be used in different experiences and exercises.

  19. The Living Labs: Innovation in Real-Life Settings

    Science.gov (United States)

    Hawk, Nathan; Bartle, Gamin; Romine, Martha

    2012-01-01

    The living lab (LL) is an open innovation ecosystem serving to provide opportunities for local stakeholders to practice research and to experiment with meaningful improvements for cities and other organizations. Living labs aim at involving the user as a cocreator. In this article the relationship between the LLs and a variety of stakeholders is…

  20. Aerial view of the water reservoirs for Lab II

    CERN Multimedia

    1974-01-01

    Two large reservoirs (5000 m3 each) were built on the Swiss part of the site (Lab I is on the left). The water was drawn from the pumping station at Le Vengeron on Lac Léman, through a 10 km long pipe to be distributed over all Lab II.

  1. The Global MRIO Lab - charting the world economy

    NARCIS (Netherlands)

    Lenzen, Manfred; Geschke, Arne; Rahman, Muhammad Daaniyall Abd; Xiao, Yanyan; Fry, Jacob; Reyes, Rachel; Dietzenbacher, Hendrikus; Inomata, Satoshi; Kanemoto, Keiichiro; Los, Bart; Moran, Daniel; Schulte in den Bäumen, Hagen; Tukker, Arnold; Walmsley, Terrie; Wiedmann, Thomas; Wood, Richard; Yamano, Norihiko

    2017-01-01

    We describe the creation of the Global Multi-Region Input-Output (MRIO) Lab, which is a cloud-computing platform offering a collaborative research environment through which participants can use each other's resources to assemble their own individual MRIO versions. The Global MRIO Lab's main purpose

  2. Macromolecules Inquiry: Transformation of a Standard Biochemistry Lab

    Science.gov (United States)

    Unsworth, Elizabeth

    2014-01-01

    Identification of macromolecules in food is a standard introductory high school biology lab. The intent of this article is to describe the conversion of this standard cookbook lab into an inquiry investigation. Instead of verifying the macromolecules found in food, students use their knowledge of the macromolecules in food to determine the…

  3. European labs brace for German cuts: international collaboration

    CERN Multimedia

    Clery, D

    1996-01-01

    Germany, the largest contributor to international European research labs, announced plans to reduce its contributions an average of 8% in the nation's latest budget. CERN and other labs are worried that the cuts will endanger ongoing projects and that other countries may follow Germany's lead.

  4. Genomics Education in Practice: Evaluation of a Mobile Lab Design

    Science.gov (United States)

    Van Mil, Marc H. W.; Boerwinkel, Dirk Jan; Buizer-Voskamp, Jacobine E.; Speksnijder, Annelies; Waarlo, Arend Jan

    2010-01-01

    Dutch genomics research centers have developed the "DNA labs on the road" to bridge the gap between modern genomics research practice and secondary-school curriculum in the Netherlands. These mobile DNA labs offer upper-secondary students the opportunity to experience genomics research through experiments with laboratory equipment that…

  5. The Multisensory Sound Lab: Sounds You Can See and Feel.

    Science.gov (United States)

    Lederman, Norman; Hendricks, Paula

    1994-01-01

    A multisensory sound lab has been developed at the Model Secondary School for the Deaf (District of Columbia). A special floor allows vibrations to be felt, and a spectrum analyzer displays frequencies and harmonics visually. The lab is used for science education, auditory training, speech therapy, music and dance instruction, and relaxation…

  6. Living Labs as boundary-spanners between Triple Helix actors

    NARCIS (Netherlands)

    van Geenhuizen, M.S.

    2016-01-01

    Living labs are an increasingly popular methodology to enhance innovation. Living labs aim to span boundaries between different organizations, among others Triple helix actors, by acting as a network organization typically in a real-life environment to foster co-creation by user-groups. This paper

  7. Engineering Students' Experiences from Physics Group Work in Learning Labs

    Science.gov (United States)

    Mellingsaeter, Magnus Strøm

    2014-01-01

    Background: This paper presents a case study from a physics course at a Norwegian university college, investigating key aspects of a group-work project, so-called learning labs, from the participating students' perspective. Purpose: In order to develop these learning labs further, the students' perspective is important. Which aspects are essential…

  8. Clinical training in medical students during preclinical years in the skill lab

    Directory of Open Access Journals (Sweden)

    Upadhayay N

    2017-03-01

    Full Text Available Namrata Upadhayay Department of Physiology, Gandaki Medical College Teaching Hospital and Research Center, Kaski, Nepal Background: In Nepal, medical education is a high-stakes and stressful course. To enhance learning and minimize students’ stress, the conventional method has been replaced by integrated, student-centered learning. As an approach to train effectively, colleges have started establishing skill labs.Objectives: To evaluate the effectiveness of clinical skill training on exam performance as compared with the conventional teaching practice. Further, to assess the perceptions of students of the importance of skill lab training in college.Method: Twenty students were randomly selected to participate in this cross-sectional study. On the internal examination, students showed skills on manikins, and examiners evaluated them. A sample question in the exam was “To perform cardiopulmonary resuscitation (CPR on half body human manikin.” On completion of the exam, opinions were collected from the students via a predesigned self-administered questionnaire. The questionnaire included questions regarding skill lab use and its benefits to them in developing their skills, with a few questions related to the exam pattern. The responses were expressed in frequencies.Results: We found that all (20/20 students performed CPR with confidence and without hesitation on the manikin. The practical examination performance (marks was categorized as excellent (7/20, good (8/20, average (3/20, and poor (2/20. The pass percentage after skill training was increased by 25% as compared with conventional teaching practice. The majority of the students (17/20 mentioned that skill is better learned by doing than by observing others’ performance or watching videos. A few students (6/20 said skills are better learned by observing the real disease state. They mentioned that skill lab is the better choice for learning major skills such as catheterization, opening

  9. The Met-genotype of the BDNF Val66Met polymorphism is associated with reduced Stroop interference in elderly.

    Science.gov (United States)

    Gajewski, Patrick D; Hengstler, Jan G; Golka, Klaus; Falkenstein, Michael; Beste, Christian

    2012-12-01

    Aging is accompanied by impairments of executive functions that rely on the functional integrity of fronto-striatal networks. This integrity is modulated by the release of neurotrophins like the brain-derived-neurotrophic factor (BDNF). Here, we investigate effects of the functional BDNF Val66Met polymorphism on interference processing in 131 healthy elderly subjects using event-related potentials (ERPs). In a Stroop task, participants had to indicate the name or the colour of colour-words while colour was either compatible or incompatible with the name. We show that susceptibility to Stroop-interference is affected by the BDNF Val66Met polymorphism: the Met-allele carriers showed better performance and enhanced N450 in interference trials. Other processes necessary to prepare and allocate cognitive resources to a particular task were not affected by BDNF Val66Met polymorphism, underlining the specificity of the observed effects. The observed performance and ERP difference is possibly due to dopamine related effects of BDNF in fronto-striatal networks, where it putatively mediates a shift in the balance of the direct and indirect pathway involved in inhibitory functions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. The Work Smart Standards process at Jefferson Lab

    International Nuclear Information System (INIS)

    The Thomas Jefferson National Accelerator Facility (Jefferson Lab) has developed a set of Work Smart Standards for the Lab. The effort incorporated the Lab's performance-based contract into the Necessary and Sufficient (N and S) Standards identification process of the DOE. A rigorous protocol identified hazards in the workplace and standards that provide adequate protection of workers, public, and the environment at reasonable cost. The intensive process was a joint effort between the Lab and DOE and it required trained teams of knowledgeable experts in three fields: (1) actual required work conditions at Jefferson Lab; (2) laws, regulations, DOE directives and performance-based contracts; and (3) Environmental Health and Safety (EH and S), Rad Con, and QA. The criteria for selection of the teams, the database designed and used for the process, and lessons learned are discussed

  11. Use of tablets for instruction and learning in microbiology labs

    DEFF Research Database (Denmark)

    Møller, Karen Louise; Jelsbak, Vibe Alopaeus; Georgsen, Marianne

    ? The empirical part of the project has been documented through field observations in the lab (in writing and with photos). We have found the following to be characteristic of the work of the students: the students use the tablets collaboratively, take more photos than requested, use the video based instructions......In the Bachelor Programme of Biomedical Laboratory Analysis at University College VIA, the students work in a classified microbiology laboratory. This means that they are not allowed to bring their personal computers into the lab. Until now the students have used paper based lab instructions...... and taken notes by hand. Use of tablets in the lab offers new opportunities. In September 2012, nine tablets were introduced into one of the labs of the college. Groups of students use the tablets to access documents, watch video instructions, and to document results and procedures digitally. The objectives...

  12. Lab-on-paper micro- and nano-analytical devices: Fabrication, modification, detection and emerging applications

    International Nuclear Information System (INIS)

    Xu, Yuanhong; Liu, Mengli; Kong, Na; Liu, Jingquan

    2016-01-01

    Paper-based chips (PB-chips; also referred to as lab-on-paper chips) are using patterned paper as a substrate in a lab-on-a-chip platform. They represent an outstanding technique for fabrication of analytical devices for multiplex analyte assays. Typical features include low-cost, portability, disposability and small sample consumption. This review (with 211 refs.) gives a comprehensive and critical insight into current trends in terms of materials and techniques for use in fabrication, modification and detection. Following an introduction into the principles of PB-chips, we discuss features of using paper in lab-on-a-chip devices and the proper choice of paper. We then discuss the versatile methods known for fabrication of PB-chips (ranging from photolithography, plasma treatment, ink jet etching, plotting, to printing including flexographic printing). The modification of PB-chips with micro- and nano-materials possessing superior optical or electronic properties is then reviewed, and the final section covers detection techniques (such as colorimetry, electrochemistry, electrochemiluminescence and chemiluminescence) along with specific (bio)analytical examples. A conclusion and outlook section discusses the challenges and future prospectives in this field. (author)

  13. Activating mutation in MET oncogene in familial colorectal cancer

    Directory of Open Access Journals (Sweden)

    Schildkraut Joellen M

    2011-10-01

    Full Text Available Abstract Background In developed countries, the lifetime risk of developing colorectal cancer (CRC is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherited colon cancer syndromes account for approximately 5%, leaving greater than 20% without clear genetic definition. Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility. Methods MET exons were amplified by PCR from germline DNA of 148 affected sibling pairs with colorectal cancer. Amplicons with altered sequence were detected with high-resolution melt-curve analysis using a LightScanner (Idaho Technologies. Samples demonstrating alternative melt curves were sequenced. A TaqMan assay for the specific c.2975C >T change was used to confirm this mutation in a cohort of 299 colorectal cancer cases and to look for allelic amplification in tumors. Results Here we report a germline non-synonymous change in the MET proto-oncogene at amino acid position T992I (also reported as MET p.T1010I in 5.2% of a cohort of sibling pairs affected with CRC. This genetic variant was then confirmed in a second cohort of individuals diagnosed with CRC and having a first degree relative with CRC at prevalence of 4.1%. This mutation has been reported in cancer cells of multiple origins, including 2.5% of colon cancers, and in Conclusions Although the MET p.T992I genetic mutation is commonly found in somatic colorectal cancer tissues, this is the first report also implicating this MET genetic mutation as a germline inherited risk factor for familial colorectal cancer. Future studies on the cancer risks associated with this mutation and the prevalence in different at-risk populations will

  14. Learning by Viewing - Nobel Labs 360

    Science.gov (United States)

    Mather, John C.

    2013-01-01

    First of all, my thanks to the Nobel Lindau Foundation for their inspiration and leadership in sharing the excitement of scientific discovery with the public and with future scientists! I have had the pleasure of participating twice in the Lindau meetings, and recently worked with the Nobel Labs 360 project to show how we are building the world's greatest telescope yet, the James Webb Space Telescope (JWST). For the future, I see the greatest challenges for all the sciences in continued public outreach and inspiration. Outreach, so the public knows why we are doing what we are doing, and what difference it makes for them today and in the long-term future. Who knows what our destiny may be? It could be glorious, or not, depending on how we all behave. Inspiration, so that the most creative and inquisitive minds can pursue the scientific and engineering discoveries that are at the heart of so much of human prosperity, health, and progress. And, of course, national and local security depend on those discoveries too; scientists have been working with "the government" throughout recorded history. For the Lindau Nobel experiment, we have a truly abundant supply of knowledge and excitement, through the interactions of young scientists with the Nobelists, and through the lectures and the video recordings we can now share with the whole world across the Internet. But the challenge is always to draw attention! With 7 billion inhabitants on Earth, trying to earn a living and have some fun, there are plenty of competing opportunities and demands on us all. So what will draw attention to our efforts at Lindau? These days, word of mouth has become word of (computer) mouse, and ideas propagate as viruses ( or memes) across the Internet according to the interests of the participants. So our challenge is to find and match those interests, so that the efforts of our scientists, photographers, moviemakers, and writers are rewarded by our public. The world changes every day, so there

  15. Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders.

    Science.gov (United States)

    Carrà, Giuseppe; Nicolini, Gabriella; Crocamo, Cristina; Lax, Annamaria; Amidani, Francesca; Bartoli, Francesco; Castellano, Filippo; Chiorazzi, Alessia; Gamba, Giulia; Papagno, Costanza; Clerici, Massimo

    2017-07-01

    A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis. To explore the potential moderating effect of these factors, a cross-sectional study was conducted, randomly recruiting subjects with DSM-IV diagnosis of schizophrenia. AUD/SUD was rigorously assessed, as well as COMT Val158Met polymorphism. Executive control functioning was measured using the Intra-Extra Dimensional Set Shift (IED). The effect of a possible interaction between comorbid AUD/SUD and COMT Val158Met polymorphism on IED scores was explored. Subjects with schizophrenia, comorbid AUD/SUD, and MetMet carriers for SNP rs4680 of the COMT gene showed worse performance on IED completed stages scores, as compared with individuals with ValVal genotype. However, among subjects without AUD/SUD, those with the MetMet variant performed better than people carrying ValVal genotype. This study is the first to date examining the impact of COMT on cognition in a highly representative sample of people with schizophrenia and comorbid AUD/SUD. Differential moderating effects of COMT Val/Met genotype variations may similarly influence executive functions in people with schizophrenia and comorbid AUD/SUD.

  16. MET-RODOS: A comprehensive atmospheric dispersion module

    DEFF Research Database (Denmark)

    Mikkelsen, T.; Thykier-Nielsen, S.; Astrup, P.

    1997-01-01

    air concentrations, and ground level gamma dose rates from up to 15 simultaneous released nuclides are calculated using a nested system of local and long range atmospheric dispersion models, driven by real-time available on-line meteorological information. The MET-PODOS module uses concurrently...... the available source term and weather information in the RODOS data base system, and returns, up to +36 h forecasts of nuclei-specific air and deposited concentrations including gamma dose rate estimations for display and subsequent processing within the RODOS framework. Weather and meteorology is available...... for operational use in 1999, the: MET-RODOS meteorological module is intended to service the PODOS system with actual and forecast (+36 h) nuclei-specific air concentrations, deposition values, and gamma radiation estimates on the local, national, and European scale. Provisions are furthermore being made...

  17. Operational Use of OGC Web Services at the Met Office

    Science.gov (United States)

    Wright, Bruce

    2010-05-01

    The Met Office has adopted the Service-Orientated Architecture paradigm to deliver services to a range of customers through Rich Internet Applications (RIAs). The approach uses standard Open Geospatial Consortium (OGC) web services to provide information to web-based applications through a range of generic data services. "Invent", the Met Office beta site, is used to showcase Met Office future plans for presenting web-based weather forecasts, product and information to the public. This currently hosts a freely accessible Weather Map Viewer, written in JavaScript, which accesses a Web Map Service (WMS), to deliver innovative web-based visualizations of weather and its potential impacts to the public. The intention is to engage the public in the development of new web-based services that more accurately meet their needs. As the service is intended for public use within the UK, it has been designed to support a user base of 5 million, the analysed level of UK web traffic reaching the Met Office's public weather information site. The required scalability has been realised through the use of multi-tier tile caching: - WMS requests are made for 256x256 tiles for fixed areas and zoom levels; - a Tile Cache, developed in house, efficiently serves tiles on demand, managing WMS request for the new tiles; - Edge Servers, externally hosted by Akamai, provide a highly scalable (UK-centric) service for pre-cached tiles, passing new requests to the Tile Cache; - the Invent Weather Map Viewer uses the Google Maps API to request tiles from Edge Servers. (We would expect to make use of the Web Map Tiling Service, when it becomes an OGC standard.) The Met Office delivers specialist commercial products to market sectors such as transport, utilities and defence, which exploit a Web Feature Service (WFS) for data relating forecasts and observations to specific geographic features, and a Web Coverage Service (WCS) for sub-selections of gridded data. These are locally rendered as maps or

  18. Testing ATLAS Z+MET excess with LHC run 2

    International Nuclear Information System (INIS)

    Lu, Xiaochuan; Terada, Takahiro

    2016-05-01

    The ATLAS collaboration reported a 3σ excess in the search of events containing on-Z dilepton, jets, and large missing momentum (MET) in the 8 TeV LHC run. Motivated by this excess, many models of new physics have been proposed. Recently, the ATLAS and CMS collaborations reported new results for similar Z+MET channels in the 13 TeV run. In this paper, we comprehensively discuss the consistency between the proposed models and the LHC results of Run 1 and Run 2. We find that in models with heavy gluino production, there is generically some tension between the 8 TeV and 13 TeV results. On the other hand, models with light squark production provide relatively better fitting to both results.

  19. Estimation of METs by Accelerometers while Walking and Running

    Science.gov (United States)

    Kurihara, Yosuke; Watanabe, Kajiro; Yoneyama, Mitsuru

    It is quite important for Japan to maintain or promote the health condition of elderly citizens. Given the circumstances, the Ministry of Health, Labour and Welfare has established the standards for the activities and exercises for promoting the health, and quantitatively determined the exercise intensity on 107 items of activities. This exercise intensity, however, requires recording the type and the duration of the activity to be calculated. In this paper, the exercise intensities are surmised using 3D accelerometer while the subjects are walking and running. As the result, the exercise intensities were surmised to be within the root mean square error of 1.2[METs] for walking and 3.2[METs] for running respectively.

  20. UniSchooLabs Toolkit: Tools and Methodologies to Support the Adoption of Universities’ Remote and Virtual Labs in Schools

    Directory of Open Access Journals (Sweden)

    Augusto Chioccariello

    2012-11-01

    Full Text Available The UniSchooLabs project aims at creating an infrastructure supporting web access to remote/virtual labs and associated educational resources to engage learners with hands-on and minds-on activities in science, technology and math in schools. The UniSchooLabs tool-kit supports the teacher in selecting a remote or virtual lab and developing a lab activity based on an inquiry model template. While working with the toolkit the teacher has access to three main features: a a catalogue of available online laboratories; b an archive of activities created by other users; c a tool for creating new activities or reusing existing ones.

  1. Designing virtual science labs for the Islamic Academy of Delaware

    Science.gov (United States)

    AlZahrani, Nada Saeed

    Science education is a basic part of the curriculum in modern day classrooms. Instructional approaches to science education can take many forms but hands-on application of theory via science laboratory activities for the learner is common. Not all schools have the resources to provide the laboratory environment necessary for hands-on application of science theory. Some settings rely on technology to provide a virtual laboratory experience instead. The Islamic Academy of Delaware (IAD), a typical community-based organization, was formed to support and meet the essential needs of the Muslim community of Delaware. IAD provides science education as part of the overall curriculum, but cannot provide laboratory activities as part of the science program. Virtual science labs may be a successful model for students at IAD. This study was conducted to investigate the potential of implementing virtual science labs at IAD and to develop an implementation plan for integrating the virtual labs. The literature has shown us that the lab experience is a valuable part of the science curriculum (NBPTS, 2013, Wolf, 2010, National Research Council, 1997 & 2012). The National Research Council (2012) stressed the inclusion of laboratory investigations in the science curriculum. The literature also supports the use of virtual labs as an effective substitute for classroom labs (Babateen, 2011; National Science Teachers Association, 2008). Pyatt and Simms (2011) found evidence that virtual labs were as good, if not better than physical lab experiences in some respects. Although not identical in experience to a live lab, the virtual lab has been shown to provide the student with an effective laboratory experience in situations where the live lab is not possible. The results of the IAD teacher interviews indicate that the teachers are well-prepared for, and supportive of, the implementation of virtual labs to improve the science education curriculum. The investigator believes that with the

  2. MetWAMer: eukaryotic translation initiation site prediction

    Directory of Open Access Journals (Sweden)

    Brendel Volker

    2008-09-01

    Full Text Available Abstract Background Translation initiation site (TIS identification is an important aspect of the gene annotation process, requisite for the accurate delineation of protein sequences from transcript data. We have developed the MetWAMer package for TIS prediction in eukaryotic open reading frames of non-viral origin. MetWAMer can be used as a stand-alone, third-party tool for post-processing gene structure annotations generated by external computational programs and/or pipelines, or directly integrated into gene structure prediction software implementations. Results MetWAMer currently implements five distinct methods for TIS prediction, the most accurate of which is a routine that combines weighted, signal-based translation initiation site scores and the contrast in coding potential of sequences flanking TISs using a perceptron. Also, our program implements clustering capabilities through use of the k-medoids algorithm, thereby enabling cluster-specific TIS parameter utilization. In practice, our static weight array matrix-based indexing method for parameter set lookup can be used with good results in data sets exhibiting moderate levels of 5'-complete coverage. Conclusion We demonstrate that improvements in statistically-based models for TIS prediction can be achieved by taking the class of each potential start-methionine into account pending certain testing conditions, and that our perceptron-based model is suitable for the TIS identification task. MetWAMer represents a well-documented, extensible, and freely available software system that can be readily re-trained for differing target applications and/or extended with existing and novel TIS prediction methods, to support further research efforts in this area.

  3. The NOAO Data Lab virtual storage system

    Science.gov (United States)

    Graham, Matthew J.; Fitzpatrick, Michael J.; Norris, Patrick; Mighell, Kenneth J.; Olsen, Knut; Stobie, Elizabeth B.; Ridgway, Stephen T.; Bolton, Adam S.; Saha, Abhijit; Huang, Lijuan W.

    2016-07-01

    Collaborative research/computing environments are essential for working with the next generations of large astronomical data sets. A key component of them is a distributed storage system to enable data hosting, sharing, and publication. VOSpace1 is a lightweight interface providing network access to arbitrary backend storage solutions and endorsed by the International Virtual Observatory Alliance (IVOA). Although similar APIs exist, such as Amazon S3, WebDav, and Dropbox, VOSpace is designed to be protocol agnostic, focusing on data control operations, and supports asynchronous and third-party data transfers, thereby minimizing unnecessary data transfers. It also allows arbitrary computations to be triggered as a result of a transfer operation: for example, a file can be automatically ingested into a database when put into an active directory or a data reduction task, such as Sextractor, can be run on it. In this paper, we shall describe the VOSpace implementations that we have developed for the NOAO Data Lab. These offer both dedicated remote storage, accessible as a local file system via FUSE, and a local VOSpace service to easily enable data synchronization.

  4. Featured Image: Making Dust in the Lab

    Science.gov (United States)

    Kohler, Susanna

    2017-12-01

    This remarkable photograph (which spans only 10 m across; click for a full view) reveals what happens when you form dust grains in a laboratory under conditions similar to those of interstellar space. The cosmic life cycle of dust grains is not well understood we know that in the interstellar medium (ISM), dust is destroyed at a higher rate than it is produced by stellar sources. Since the amount of dust in the ISM stays constant, however, there must be additional sources of dust production besides stars. A team of scientists led by Daniele Fulvio (Pontifical Catholic University of Rio de Janeiro and the Max Planck Institute for Astronomy at the Friedrich Schiller University Jena) have now studied formation mechanisms of dust grains in the lab by mimicking low-temperature ISM conditions and exploring how, under these conditions, carbonaceous materials condense from gas phase to form dust grains. To read more about their results and see additional images, check out the paper below.CitationDaniele Fulvio et al 2017 ApJS 233 14. doi:10.3847/1538-4365/aa9224

  5. BOREAS TE-1 SSA Soil Lab Data

    Science.gov (United States)

    Hall, Forrest G. (Editor); Knapp, David E. (Editor); Nerbas, Tim; Anderson, Darwin

    2000-01-01

    This data set was collected by TE-1 to provide a set of soil properties for BOREAS investigators in the SSA. The soil samples were collected at sets of soil pits in 1993 and 1994. Each set of soil pits was in the vicinity of one of the five flux towers in the BOREAS SSA. The collected soil samples were sent to a lab, where the major soil properties were determined. These properties include, but are not limited to, soil horizon; dry soil color; pH; bulk density; total, organic, and inorganic carbon; electric conductivity; cation exchange capacity; exchangeable sodium, potassium, calcium, magnesium, and hydrogen; water content at 0.01, 0.033, and 1.5 MPascals; nitrogen; phosphorus; particle size distribution; texture; pH of the mineral soil and of the organic soil; extractable acid; and sulfur. The data are stored in tabular ASCII text files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  6. Di-hadron production at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    Anefalos Pereira, Sergio [Lab. Naz. Frascati, Frascati, Italy; et. al.,

    2014-10-01

    Semi-inclusive deep inelastic scattering (SIDIS) has been used extensively in recent years as an important testing ground for QCD. Studies so far have concentrated on better determination of parton distribution functions, distinguishing between the quark and antiquark contributions, and understanding the fragmentation of quarks into hadrons. Hadron pair (di-hadron) SIDIS provides information on the nucleon structure and hadronization dynamics that complement single hadron SIDIS. Di-hadrons allow the study of low- and high-twist distribution functions and Dihadron Fragmentation Functions (DiFF). Together with the twist-2 PDFs ( f1, g1, h1), the Higher Twist (HT) e and hL functions are very interesting because they offer insights into the physics of the largely unexplored quark-gluon correlations, which provide access into the dynamics inside hadrons. The CLAS spectrometer, installed in Hall-B at Jefferson Lab, has collected data using the CEBAF 6 GeV longitudinally polarized electron beam on longitudinally polarized solid NH3 targets. Preliminary results on di-hadron beam-, target- and double-spin asymmetries will be presented.

  7. El sexo de las metáforas

    Directory of Open Access Journals (Sweden)

    Pérez Sedeño, Eulalia

    2011-02-01

    Full Text Available The hypothesis that states metaphors are structurally determinant in our social relations, routines, and experience has been accepted broadly in the last decades. Moreover, metaphors are to be found in many different levels of scientific practices, and have a diverse set of functions in science. Therefore, they impregnate all scientific enterprise. In this work we examine selected gender metaphors used in biology. We show metaphors are effective precisely because its effectiveness depends on shared social conventions, kinship relations and, authority that, by convention, is given to those that use them.

    La tesis de que las metáforas estructuran gran parte de nuestras relaciones sociales y nuestra experiencia cotidiana ha sido ampliamente aceptada en las últimas décadas. En la ciencia, además, aparecen en muchos niveles y desempeñan diversas funciones, impregnando todo el quehacer científico. En este trabajo se examinan algunas metáforas de género usadas en biología. Se muestra que las metáforas eficaces lo son porque su efectividad depende de las convenciones sociales compartidas, los parecidos de familia ya vigentes y de la autoridad que, por convención, se otorga a quienes las usan.

  8. A new LabVIEW interface for MDSplus

    Energy Technology Data Exchange (ETDEWEB)

    Manduchi, G., E-mail: gabriele.manduchi@igi.cnr.it [Consorzio RFX, Euratom-ENEA Association, Padova (Italy); De Marchi, E. [Department of Information Engineering, Padova University (Italy); Mandelli, A. [National Instruments (Italy)

    2013-10-15

    Highlights: ► Integration object oriented data access layer in LabVIEW. ► A new component of the MDSplus data acquisition package. ► A new approach in the graphical presentation of data acquisition systems. -- Abstract: The paper presents a new interface providing full integration of MDSplus in LabVIEW, based on the recent features of MDSplus, in particular, data streaming, multithreading and Object Oriented interface. Data streaming support fits into the data driven concept of LabVIEW and multithreading is a native concept in LabVIEW. The object oriented interface of MDSplus defines a set of classes which map specific functionality, such as Tree and TreeNode to represent pulse files and data items, respectively, and fits naturally into the LabVIEW Object Oriented programming interface (LVOOP) introduced in version 8.2. MDSplus objects have been mapped onto LabVIEW objects, which act as wrappers to the underlying MDSplus object instance. This approach allows exporting the full MDSplus functionality into LabVIEW retaining the language-independent system view provided by the MDSplus object oriented interface.

  9. A new LabVIEW interface for MDSplus

    International Nuclear Information System (INIS)

    Manduchi, G.; De Marchi, E.; Mandelli, A.

    2013-01-01

    Highlights: ► Integration object oriented data access layer in LabVIEW. ► A new component of the MDSplus data acquisition package. ► A new approach in the graphical presentation of data acquisition systems. -- Abstract: The paper presents a new interface providing full integration of MDSplus in LabVIEW, based on the recent features of MDSplus, in particular, data streaming, multithreading and Object Oriented interface. Data streaming support fits into the data driven concept of LabVIEW and multithreading is a native concept in LabVIEW. The object oriented interface of MDSplus defines a set of classes which map specific functionality, such as Tree and TreeNode to represent pulse files and data items, respectively, and fits naturally into the LabVIEW Object Oriented programming interface (LVOOP) introduced in version 8.2. MDSplus objects have been mapped onto LabVIEW objects, which act as wrappers to the underlying MDSplus object instance. This approach allows exporting the full MDSplus functionality into LabVIEW retaining the language-independent system view provided by the MDSplus object oriented interface

  10. Can Direct Measurement Videos Inspire Lab-like Learning?

    Science.gov (United States)

    Vonk, M.; Bohacek, P. H.

    2014-12-01

    Hands-on labs can offer students a rare opportunity to confront the laws of physics first hand and to gain experience using science practices. As such, hands-on labs are an important learning tool which have played a foundational role in science education since the time of Galileo. But labs also have features that make them difficult to implement in practice. They are often time consuming for the instructor to plan and setup, time consuming for students to perform, expensive to implement, and fraught with potential missteps that can send confused students into a spiral of misunderstanding. Our Direct Measurement Video team is working to create several series' of videos with an interface that allows students to interact with them in a way that (we hope) will start to feel lab-like, but with fewer of the impediments that tend to undermine lab-learning in the real world. We hope that lab-like videos will soon provide a needed complement to traditional hands-on labs in science classrooms across the nation. In this talk, I will present our vision of the pedagogical possibilities of video and highlight our progress toward the goal. This work is supported by NSF TUES award #1245268

  11. GeoLab: A Geological Workstation for Future Missions

    Science.gov (United States)

    Evans, Cynthia; Calaway, Michael; Bell, Mary Sue; Li, Zheng; Tong, Shuo; Zhong, Ye; Dahiwala, Ravi

    2014-01-01

    The GeoLab glovebox was, until November 2012, fully integrated into NASA's Deep Space Habitat (DSH) Analog Testbed. The conceptual design for GeoLab came from several sources, including current research instruments (Microgravity Science Glovebox) used on the International Space Station, existing Astromaterials Curation Laboratory hardware and clean room procedures, and mission scenarios developed for earlier programs. GeoLab allowed NASA scientists to test science operations related to contained sample examination during simulated exploration missions. The team demonstrated science operations that enhance theThe GeoLab glovebox was, until November 2012, fully integrated into NASA's Deep Space Habitat (DSH) Analog Testbed. The conceptual design for GeoLab came from several sources, including current research instruments (Microgravity Science Glovebox) used on the International Space Station, existing Astromaterials Curation Laboratory hardware and clean room procedures, and mission scenarios developed for earlier programs. GeoLab allowed NASA scientists to test science operations related to contained sample examination during simulated exploration missions. The team demonstrated science operations that enhance the early scientific returns from future missions and ensure that the best samples are selected for Earth return. The facility was also designed to foster the development of instrument technology. Since 2009, when GeoLab design and construction began, the GeoLab team [a group of scientists from the Astromaterials Acquisition and Curation Office within the Astromaterials Research and Exploration Science (ARES) Directorate at JSC] has progressively developed and reconfigured the GeoLab hardware and software interfaces and developed test objectives, which were to 1) determine requirements and strategies for sample handling and prioritization for geological operations on other planetary surfaces, 2) assess the scientific contribution of selective in-situ sample

  12. A mobile design lab for user-driven innovation

    DEFF Research Database (Denmark)

    Christiansen, Ellen; Kanstrup, Anne Marie

    2007-01-01

    The paper presents the history and conceptual foundation for the Mobile Design Lab, ment to support both designers and users in the acts of user-driven innovation. The Mobile Design Lab is based on Vygotsky's theory of tool- and language-mediation, and was created in 2004 to support research...... to get 'into the street'. To support these moves might seem simple, but it is in practice not at all easy. As for today the Mobile Design Lab comprises tools and techniques for categorization, articulation and concretizatoin in design projects involving lead users as well as ordinary users, and invisible...

  13. Living lab: Format for rehearsing a new (service) practice

    DEFF Research Database (Denmark)

    Yndigegn, Signe; Aakjær, Marie Kirstejn

    service platforms takes place in the format of living labs. We characterize living labs as the design of experiential spaces where ‘what is’ and ‘what could be’ are explored over a longer period of engagement. The labs are staged to integrate multiple stakeholders’ issues and resources and to create new......Citizen engagement and the citizens as a resource are key concepts in rethinking the Danish welfare system to meet the challenges of delivering better services for the elderly, while simultaneously reducing the cost of healthcare. In this method paper, we address how the co-design of new digital...

  14. [Probiotics: from the lab to the consumer].

    Science.gov (United States)

    Rodríguez, J M

    2015-02-07

    In the last years, the field of probiotics has grown notably. However, out of the thousands of strains isolated each year in the labs around the world, very few enter in a phase of industrial development and even a lower number go to the market. In this article, the main aspects that have to be taken into account in the, usually, long and winding road that a strain must follow from isolation to the market are reviewed Results and conclusions: A probiotic microorganism has to be correctly identified at the species and strain levels. The genome sequence is the gold identification standard and provides valuable information on the safety, functionality and technological properties of a strain. The cases in which a link between a probiotic and an adverse effect has been established are scarce and have involved people with underlying pathologies. There is a wide variety of in vitro, ex vivo and animal model assays for the screening of probiotics, which provide useful information throughout the selection process; however, correctly designed clinical trials are the only way to obtain direct results on the safety and efficacy of a probiotic to the target population. Probiotic companies have the need to obtain a very high bacterial biomass in an economically viable manner while preserving the concentration of live bacteria required for exerting the expected beneficial effect until the end of the probiotic's shelf life. Finally, commercial aspects play a key role in the decision of starting an industrial development and, eventually, to place a probiotic in the market. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  15. Link Analysis in the Mission Planning Lab

    Science.gov (United States)

    McCarthy, Jessica A.; Cervantes, Benjamin W.; Daugherty, Sarah C.; Arroyo, Felipe; Mago, Divyang

    2011-01-01

    The legacy communications link analysis software currently used at Wallops Flight Facility involves processes that are different for command destruct, radar, and telemetry. There is a clear advantage to developing an easy-to-use tool that combines all the processes in one application. Link Analysis in the Mission Planning Lab (MPL) uses custom software and algorithms integrated with Analytical Graphics Inc. Satellite Toolkit (AGI STK). The MPL link analysis tool uses pre/post-mission data to conduct a dynamic link analysis between ground assets and the launch vehicle. Just as the legacy methods do, the MPL link analysis tool calculates signal strength and signal- to-noise according to the accepted processes for command destruct, radar, and telemetry assets. Graphs and other custom data are generated rapidly in formats for reports and presentations. STK is used for analysis as well as to depict plume angles and antenna gain patterns in 3D. The MPL has developed two interfaces with the STK software (see figure). The first interface is an HTML utility, which was developed in Visual Basic to enhance analysis for plume modeling and to offer a more user friendly, flexible tool. A graphical user interface (GUI) written in MATLAB (see figure upper right-hand corner) is also used to quickly depict link budget information for multiple ground assets. This new method yields a dramatic decrease in the time it takes to provide launch managers with the required link budgets to make critical pre-mission decisions. The software code used for these two custom utilities is a product of NASA's MPL.

  16. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations.

    Science.gov (United States)

    Tanizaki, Junko; Okamoto, Isamu; Okamoto, Kunio; Takezawa, Ken; Kuwata, Kiyoko; Yamaguchi, Haruka; Nakagawa, Kazuhiko

    2011-10-01

    Tyrosine kinase inhibitors (TKIs) targeted to MET are undergoing clinical trials in patients with solid tumors, but the precise mechanism of the antitumor activity of these drugs remains unclear. We examined the antitumor action of the MET-TKI crizotinib (PF-02341066) in lung cancer cells that are positive or negative for MET amplification or mutation. The antitumor action of crizotinib was evaluated on the basis of signal transduction, cell proliferation, apoptosis, and progression of tumor xenografts. Inhibition of MET signaling by crizotinib or by RNA interference-mediated MET depletion resulted in the induction of apoptosis accompanied by inhibition of AKT and extracellular signal-regulated kinase phosphorylation in lung cancer cells with MET amplification but not in cells with a MET mutation or in those without amplification or mutation of MET. These results suggest that MET signaling is essential for the survival of cells with MET amplification but not for that of cells without this genetic change, including those with a MET mutation. Crizotinib up-regulated the expression of BIM, a proapoptotic member of the Bcl-2 family, and down-regulated that of survivin, a member of the inhibitor of apoptosis protein family, in cells with MET amplification. Forced depletion of BIM and expression of survivin each inhibited crizotinib-induced apoptosis, suggesting that both up-regulation of BIM and down-regulation of survivin contribute to the proapoptotic effect of crizotinib. Crizotinib shows a marked antitumor action in MET amplification-positive lung cancer cells but not in cells without MET amplification, including those with a MET mutation.

  17. MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor.

    Science.gov (United States)

    Togashi, Yosuke; Mizuuchi, Hiroshi; Tomida, Shuta; Terashima, Masato; Hayashi, Hidetoshi; Nishio, Kazuto; Mitsudomi, Tetsuya

    2015-12-01

    MET splice site mutations resulting in an exon 14 deletion have been reported to be present in about 3% of all lung adenocarcinomas. Patients with lung adenocarcinoma and a MET splice site mutation who have responded to MET inhibitors have been reported. The CRISPR/Cas9 system is a recently developed genome-engineering tool that can easily and rapidly cause small insertions or deletions. We created an in vitro model for MET exon 14 deletion using the CRISPR/Cas9 system and the HEK293 cell line. The phenotype, which included MET inhibitor sensitivity, was then investigated in vitro. Additionally, MET splice site mutations were analyzed in several cancers included in The Cancer Genome Atlas (TCGA) dataset. An HEK293 cell line with a MET exon 14 deletion was easily and rapidly created; this cell line had a higher MET protein expression level, enhanced MET phosphorylation, and prolonged MET activation. In addition, a direct comparison of phenotypes using this system demonstrated enhanced cellular growth, colony formation, and MET inhibitor sensitivity. In the TCGA dataset, lung adenocarcinomas had the highest incidence of MET exon 14 deletions, while other cancers rarely carried such mutations. Approximately 10% of the lung adenocarcinoma samples without any of driver gene alterations carried the MET exon 14 deletion. These findings suggested that this system may be useful for experiments requiring the creation of specific mutations, and the present experimental findings encourage the development of MET-targeted therapy against lung cancer carrying the MET exon 14 deletion. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. MieLab: A Software Tool to Perform Calculations on the Scattering of Electromagnetic Waves by Multilayered Spheres

    International Nuclear Information System (INIS)

    Pena-Rodriguez, O.; Perez, P.P.G.; Pal, U.

    2011-01-01

    In this paper, we present MieLab, a free computational package for simulating the scattering of electromagnetic radiation by multilayered spheres or an ensemble of particles with normal size distribution. It has been designed as a virtual laboratory, including a friendly graphical user interface (GUI), an optimization algorithm (to fit the simulations to experimental results) and scripting capabilities. The paper is structured in five different sections: the introduction is a perspective on the importance of the software for the study of scattering of light scattering. In the second section, various approaches used for modeling the scattering of electromagnetic radiation by small particles are discussed. The third and fourth sections are devoted to provide an overview of MieLab and to describe the main features of its architectural model and functional behavior, respectively. Finally, several examples are provided to illustrate the main characteristics of the software

  19. MieLab: A Software Tool to Perform Calculations on the Scattering of Electromagnetic Waves by Multilayered Spheres

    Directory of Open Access Journals (Sweden)

    Ovidio Peña-Rodríguez

    2011-01-01

    Full Text Available In this paper, we present MieLab, a free computational package for simulating the scattering of electromagnetic radiation by multilayered spheres or an ensemble of particles with normal size distribution. It has been designed as a virtual laboratory, including a friendly graphical user interface (GUI, an optimization algorithm (to fit the simulations to experimental results and scripting capabilities. The paper is structured in five different sections: the introduction is a perspective on the importance of the software for the study of scattering of light scattering. In the second section, various approaches used for modeling the scattering of electromagnetic radiation by small particles are discussed. The third and fourth sections are devoted to provide an overview of MieLab and to describe the main features of its architectural model and functional behavior, respectively. Finally, several examples are provided to illustrate the main characteristics of the software.

  20. Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays.

    Science.gov (United States)

    Lee, Jong Bong; Zgair, Atheer; Taha, Dhiaa A; Zang, Xiaowei; Kagan, Leonid; Kim, Tae Hwan; Kim, Min Gi; Yun, Hwi-Yeol; Fischer, Peter M; Gershkovich, Pavel

    2017-05-01

    In this study, Caco-2 permeability results from different laboratories were compared. Six different sets of apparent permeability coefficient (P app ) values reported in the literature were compared to experimental P app obtained in our laboratory. The differences were assessed by determining the root mean square error (RMSE) values between the datasets, which reached levels as high as 0.581 for the training set compounds, i.e. ten compounds with known effective human permeability (P eff ). The consequences of these differences in P app for prediction of oral drug absorption were demonstrated by introducing the P app into the absorption and pharmacokinetics simulation software application GastroPlus™ for prediction of the fraction absorbed (F a ) in humans using calibrated "user-defined permeability models". The RMSE were calculated to assess the differences between the simulated F a and experimental values reported in the literature. The RMSE for F a simulated with the permeability model calibrated using experimental P app from our laboratory was 0.128. When the calibration was performed using P app from literature datasets, the RMSE values for F a were higher in all cases except one. This study shows quantitative lab-to-lab variability of Caco-2 permeability results and the potential consequences this can have in the use of these results for predicting intestinal absorption of drugs. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Enabling miniaturised personalised diagnostics: from lab-on-a-chip to lab-in-a-drop.

    Science.gov (United States)

    Koo, Kevin M; Wee, Eugene J H; Wang, Yuling; Trau, Matt

    2017-09-26

    The concept of personalised diagnostics is to direct accurate clinical decisions based on an individual's unique disease molecular profile. Lab-on-a-chip (LOC) systems are prime personalised diagnostics examples which seek to perform an entire sample-to-outcome detection of disease nucleic acid (NA) biomarkers on a single miniaturised platform with minimal user handling. Despite the great potential of LOC devices in providing rapid, portable, and inexpensive personalised diagnosis at the point-of-care (POC), the translation of this technology into widespread use has still been hampered by the need for sophisticated and complex engineering. As an alternative miniaturised diagnostics platform free of precision fabrication, there have been recent developments towards a solution-based lab-in-a-drop (LID) system by which an entire laboratory-based diagnostics workflow could be downscaled and integrated within a singular fluid droplet for POC detection of NA biomarkers. In contrast to existing excellent reviews on miniaturised LOC fabrication and individual steps of NA biomarker sensing, we herein focus on miniaturised solution-based NA biosensing strategies suited for integrated LID personalised diagnostics development. In this review, we first evaluate the three fundamental bioassay steps for miniaturised NA biomarker detection: crude sample preparation, isothermal target amplification, and detection readout of amplicons. Then, we provide insights into research advancements towards a functional LID system which integrates all three of the above-mentioned fundamental steps. Finally, we discuss perspectives and future directions of LID diagnostic platforms in personalised medicine applications.

  2. Diverting lava flows in the lab

    Science.gov (United States)

    Dietterich, Hannah; Cashman, Katharine V.; Rust, Alison C.; Lev, Einat

    2015-01-01

    Recent volcanic eruptions in Hawai'i, Iceland and Cape Verde highlight the challenges of mitigating hazards when lava flows threaten infrastructure. Diversion barriers are the most common form of intervention, but historical attempts to divert lava flows have met with mixed success and there has been little systematic analysis of optimal barrier design. We examine the interaction of viscous flows of syrup and molten basalt with barriers in the laboratory. We find that flows thicken immediately upslope of an obstacle, forming a localized bow wave that can overtop barriers. Larger bow waves are generated by faster flows and by obstacles oriented at a high angle to the flow direction. The geometry of barriers also influences flow behaviour. Barriers designed to split or dam flows will slow flow advance, but cause the flow to widen, whereas oblique barriers can effectively divert flows, but may also accelerate flow advance. We argue that to be successful, mitigation of lava-flow hazards must incorporate the dynamics of lava flow–obstacle interactions into barrier design. The same generalizations apply to the effect of natural topographic features on flow geometry and advance rates.

  3. MET17 and Hydrogen Sulfide Formation in Saccharomyces cerevisiae

    Science.gov (United States)

    Spiropoulos, Apostolos; Bisson, Linda F.

    2000-01-01

    Commercial isolates of Saccharomyces cerevisiae differ in the production of hydrogen sulfide (H2S) during fermentation, which has been attributed to variation in the ability to incorporate reduced sulfur into organic compounds. We transformed two commercial strains (UCD522 and UCD713) with a plasmid overexpressing the MET17 gene, which encodes the bifunctional O-acetylserine/O-acetylhomoserine sulfhydrylase (OAS/OAH SHLase), to test the hypothesis that the level of activity of this enzyme limits reduced sulfur incorporation, leading to H2S release. Overexpression of MET17 resulted in a 10- to 70-fold increase in OAS/OAH SHLase activity in UCD522 but had no impact on the level of H2S produced. In contrast, OAS/OAH SHLase activity was not as highly expressed in transformants of UCD713 (0.5- to 10-fold) but resulted in greatly reduced H2S formation. Overexpression of OAS/OAH SHLase activity was greater in UCD713 when grown under low-nitrogen conditions, but the impact on reduction of H2S was greater under high-nitrogen conditions. Thus, there was not a good correlation between the level of enzyme activity and H2S production. We measured cellular levels of cysteine to determine the impact of overexpression of OAS/OAH SHLase activity on sulfur incorporation. While Met17p activity was not correlated with increased cysteine production, conditions that led to elevated cytoplasmic levels of cysteine also reduced H2S formation. Our data do not support the simple hypothesis that variation in OAS/OAH SHLase activity is correlated with H2S production and release. PMID:11010893

  4. Sandscape - engaging people in Met Office science through sand sculpture

    Science.gov (United States)

    Liggins, Felicity; Dowell, Ellen; Wardley, Jamie; Jamieson, Claire

    2017-04-01

    In 2015, the Met Office's award-winning outreach programme, designed to inspire the next generation of scientists and engineers, delivered one of its most ambitious and creative activities to date. It explored how scientists and artists can come together to create an engaging experience for young people and families. This activity was called Sandscape. Sandscape is an interactive sand sculpture workshop exploring how weather and climate affect our health. Budding sand sculptors are shown how to fashion elaborate structures from sand and water - creating a landscape with bridges, skyscrapers, forests and factories. As they work, participants are encouraged by the scientists delivering the activity to reflect on what makes a healthy city, considering how the natural and built environments influence air quality and circulation and how this impacts our health. Topics discussed include urban heat islands, air pollution and dispersion modelling, pollen forecasting and predicting the wind-borne spread of animal diseases. Each hour long workshop culminates in a dramatic demonstration that uses dry ice to represent clean air circulating from mountains, along rivers and into cities. Here we present an overview of Sandscape, identify the strengths and challenges of such a collaborative, innovative and playful approach to public engagement and share the results of our evaluation. Sandscape was originally supported by the Met Office and the Wellcome Trust, and produced by Einstein's Garden in collaboration with the Met Office, scientists from the University of Exeter and sand sculptors from Sand in Your Eye. It was first presented in Einstein's Garden at Green Man festival 2015, an independent music and arts festival held annually in Wales, and has since been invited to run at the 2015 Bournemouth Arts By the Sea Festival and Teignmouth's TRAIL Sculpture Festival in the summer of 2016.

  5. Chapel Hill, NC Lab--Office of Research and Development

    Science.gov (United States)

    ORD scientists at the state-of-the-art lab in Chapel Hill conduct integrated research to improve our understanding of how social, economic, and health related factors affect an individual’s or com-munity’s health risks.

  6. Safety in the Chemical Laboratory: Hazards in a Photography Lab.

    Science.gov (United States)

    Houk, Cliff; Hart, Charles

    1987-01-01

    Described are case studies illustrating chemical hazards in a photography lab due to compounds containing cyanide. Suggestions for preventing problems including proper procedures, housekeeping, facilities, and ventilation are considered. (RH)

  7. VirexLab a Virtual Reality Educational System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The VirexLab, the centerpiece of this Tietronix proposal offers significant innovation to NASA and to the Marshall Space Flight Center, implementing the Biological...

  8. City Labs as Vehicles for Innovation in Urban Planning Processes

    Directory of Open Access Journals (Sweden)

    Christian Scholl

    2016-12-01

    Full Text Available This paper assesses the role of urban experiments for local planning processes through a case-based analysis of the city lab of Maastricht. In conjunction with this, the article offers three contributions, as additional elements. Firstly, the paper develops a set of defining characteristics of city labs as an analytical concept which is relevant for discussions about (collaborative planning. Secondly, it refines the literature on collaborative planning by drawing attention to experimentation and innovation. Thirdly, the paper assesses the potential of city labs to contribute to the innovation of urban governance. The work draws from the literature on experimentation and learning as well as the literature on collaborative urban planning. In the conclusions, we discuss the potential of city labs as vehicles for learning about new urban planning approaches and their limitations as spaces for small-scale experimentation. The paper is based on research for the URB@Exp research project funded by JPI Urban Europe.

  9. Lab-scale hydrogen peroxide data from ECBC

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data from small lab scale tests conducted at ECBC. It contains efficacy data as well as data on env conditions such as temperature, RH, and hydrogen peroxide vapor...

  10. Establishing an intelligent transportation systems (ITS) lab at LTRC.

    Science.gov (United States)

    2008-09-30

    The primary goal of this research project is to lay the foundation for establishing a state-of-the-art Intelligent Transportation Systems (ITS) : lab at the Louisiana Transportation Research Center (LTRC), where data will be collected, analyzed, and ...

  11. In silico and wet lab approaches to study transcriptional regulation

    NARCIS (Netherlands)

    Hestand, Matthew Scott

    2010-01-01

    Gene expression is a complicated process with multiple types of regulation, including binding of proteins termed transcription factors. This thesis looks at transcription factors and transcription factor binding site discovery through computational predictions and wet lab work to better elucidate

  12. Chapter 3 – VPPD-Lab: The Chemical Product Simulator

    DEFF Research Database (Denmark)

    Kalakul, Sawitree; Cignitti, Stefano; Zhang, L.

    2017-01-01

    for computer-aided chemical product design and evaluation, implemented in the software called VPPD-Lab, is presented. In the same way a typical process simulator works, the VPPD-Lab allows users to: (1) analyze chemical-based products by performing virtual experiments (product property and performance...... calculations), (2) predict the properties of products, and (3) create new product property and product performance models when needed. However, unlike process simulators, VPPD-Lab can also be used directly for (1) design of chemicals based products using design templates for various types of products......, such as single molecule products, formulations, blends, emulsions, and devices; and (2) to create new product design templates when the needed template for a desired product is not available. VPPD-Lab employs a suite of algorithms (such as database search, molecular and mixture blend design) and toolboxes (such...

  13. VirexLab a Virtual Reality Educational System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The VirexLab, the centerpiece of this Tietronix proposal offers significant innovation to NASA and to the Marshall Space Flight Center, implementing the Biological...

  14. A Comparative Study of virtual and operational met mast data

    International Nuclear Information System (INIS)

    Orhan, Dr Ö Emre; Ahmet, Gökhan

    2014-01-01

    Performance of wind assessment studies depend on the adequacy and duration of the wind data. For a reasonable wind assessment, at least one full year wind data is needed so that, all the variations throughout the year are represented. On the other hand, it is always a question of time and cost how to get the wind data. On-site measurements are the most common way of obtaining wind data but it is the most expensive and time consuming as well. Apart from onsite data, there are also reanalysis long term data sources like MERRA, NCAR, etc. Time and spatial resolution of these long term data are lower compared to on-site measurements but in cases where on-site measurements are not available, they are also utilized. On top of on-site and reanalysis wind data, weather forecasting models like WRF, MM5 are available. Although, these models mainly are used for forecasting services, flexibility of the models makes them suitable for preliminary resource assessment purposes. In this study, comparisons of annual energy production estimations are computed using virtual and on-site met mast data separately for a specific time range. The widely used weather research and forecasting model (WRF) is used to provide virtual met mast data. Once WRF simulations are completed, interpolation routines are employed in order to extract data for a specific location. The on-site met mast is located inside a wind farm project area which is under development. Project site is located in the south of Turkey. There are four different met masts, three of them recording wind data presently. On-site measurements together with WRF results are used to obtain energy yields for the project area. The performance of both methodologies is compared. It has been observed that WRF can as well serve as a preliminary model in cases where no other data source is available but the model has to be implemented with great care depending on the project site conditions

  15. Flare forecasting at the Met Office Space Weather Operations Centre

    OpenAIRE

    Murray, Sophie A.; Bingham, Suzy; Sharpe, Michael; Jackson, David R.

    2017-01-01

    The Met Office Space Weather Operations Centre produces 24/7/365 space weather guidance, alerts, and forecasts to a wide range of government and commercial end users across the United Kingdom. Solar flare forecasts are one of its products, which are issued multiple times a day in two forms; forecasts for each active region on the solar disk over the next 24 hours, and full-disk forecasts for the next four days. Here the forecasting process is described in detail, as well as first verification...

  16. Gail Harlamoff: Executive Director, Life Lab Science Program

    OpenAIRE

    Rabkin, Sarah

    2010-01-01

    Gail Harlamoff is Executive Director of the Life Lab Science Program, a nationally recognized, award-winning nonprofit science and environmental organization located on the UC Santa Cruz campus. Founded in 1979, Life Lab helps schools develop gardens and implement curricula to enhance students’ learning about science, math, and the natural world. The program has trained tens of thousands of educators in more than 1400 schools across the country. Life Lab’s specialized initiatives inc...

  17. Qualification Lab Testing on M1 Abrams Engine Oil Filters

    Science.gov (United States)

    2016-11-01

    OIL FILTERS FINAL REPORT TFLRF No. 483 by Kristi K. Rutta U.S...the originator. UNCLASSIFIED QUALIFICATION LAB TESTING ON M1 ABRAMS ENGINE OIL FILTERS FINAL REPORT TFLRF No. 483 by Kristi K...TITLE AND SUBTITLE Qualification Lab Testing on M1 Abrams Engine Oil Filter 5a. CONTRACT NUMBER W56HZV-15-C-0030 5b. GRANT NUMBER 5c.

  18. Implementation of Siemens USS protocol into LabVIEW.

    Science.gov (United States)

    Hosek, P; Diblik, M

    2011-10-01

    This article gives basic overview of the USS protocol as a communication interface to drive Siemens frequency inverters. It presents our implementation of this protocol into LabVIEW, as there was permanent demand from the community of the users to have native LabVIEW implementation of the USS protocol. It also states encountered problems and their solutions. Copyright © 2011 Society for Laboratory Automation and Screening. Published by Elsevier Inc. All rights reserved.

  19. A Case Study of a High School Fab Lab

    Science.gov (United States)

    Lacy, Jennifer E.

    This dissertation examines making and design-based STEM education in a formal makerspace. It focuses on how the design and implementation of a Fab Lab learning environment and curriculum affect how instructors and students see themselves engaging in science, and how the Fab Lab relates to the social sorting practices that already take place at North High School. While there is research examining design-based STEM education in informal and formal learning environments, we know little about how K-12 teachers define STEM in making activities when no university or museum partnership exists. This study sought to help fill this gap in the research literature. This case study of a formal makerspace followed instructors and students in one introductory Fab Lab course for one semester. Additional observations of an introductory woodworking course helped build the case and set it into the school context, and provided supplementary material to better understand the similarities and differences between the Fab Lab course and a more traditional design-based learning course. Using evidence from observational field notes, participant interviews, course materials, and student work, I found that the North Fab Lab relies on artifacts and rhetoric symbolic of science and STEM to set itself apart from other design-based courses at North High School. Secondly, the North Fab Lab instructors and students were unable to explain how what they were doing in the Fab Lab was science, and instead relied on vague and unsupported claims related to interdisciplinary STEM practices and dated descriptions of science. Lastly, the design and implementation of the Fab Lab learning environment and curriculum and its separation from North High School's low tech, design-based courses effectively reinforced social sorting practices and cultural assumptions about student work and intelligence.

  20. Automatic creation of LabVIEW network shared variables

    International Nuclear Information System (INIS)

    Kluge, T.; Schroeder, H.

    2012-01-01

    We are in the process of preparing the LabVIEW controlled system components of our Solid State Direct Drive experiments for the integration into a Supervisory Control And Data Acquisition (SCADA) or distributed control system. The predetermined route to this is the generation of LabVIEW network shared variables that can easily be exported by LabVIEW to the SCADA system using OLE for Process Control (OPC) or other means. Many repetitive tasks are associated with the creation of the shared variables and the required code. We are introducing an efficient and inexpensive procedure that automatically creates shared variable libraries and sets default values for the shared variables. Furthermore, LabVIEW controls are created that are used for managing the connection to the shared variable inside the LabVIEW code operating on the shared variables. The procedure takes as input an XML spread-sheet defining the required input. The procedure utilizes XSLT and LabVIEW scripting. In a later state of the project the code generation can be expanded to also create code and configuration files that will become necessary in order to access the shared variables from the SCADA system of choice. (authors)

  1. Installation and use of LabKey Server for proteomics.

    Science.gov (United States)

    Eckels, Joshua; Hussey, Peter; Nelson, Elizabeth K; Myers, Tamra; Rauch, Adam; Bellew, Matthew; Connolly, Brian; Law, Wendy; Eng, Jimmy K; Katz, Jonathan; McIntosh, Martin; Mallick, Parag; Igra, Mark

    2011-12-01

    LabKey Server (formerly CPAS, the Computational Proteomics Analysis System) provides a Web-based platform for mining data from liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic experiments. This open source platform supports systematic proteomic analyses and secure data management, integration, and sharing. LabKey Server incorporates several tools currently used in proteomic analysis, including the X! Tandem search engine, the ProteoWizard toolkit, and the PeptideProphet and ProteinProphet data mining tools. These tools and others are integrated into LabKey Server, which provides an extensible architecture for developing high-throughput biological applications. The LabKey Server analysis pipeline acts on data in standardized file formats, so that researchers may use LabKey Server with other search engines, including Mascot or SEQUEST, that follow a standardized format for reporting search engine results. Supported builds of LabKey Server are freely available at http://www.labkey.com/. Documentation and source code are available under the Apache License 2.0 at http://www.labkey.org. © 2011 by John Wiley & Sons, Inc.

  2. Future{at}Labs.Prosperity Game{trademark}

    Energy Technology Data Exchange (ETDEWEB)

    Beck, D.F.; Boyack, K.W.; Berman, M. [Sandia National Labs., Albuquerque, NM (United States). Innovative Alliances Dept.

    1996-10-01

    Prosperity Games{trademark} are an outgrowth and adaptation of move/countermove and seminar War Games, Prosperity Games{trademark} are simulations that explore complex issues in a variety of areas including economics, politics, sociology, environment, education, and research. These issues can be examined from a variety of perspectives ranging from global, macroeconomic and geopolitical viewpoint down to the details of customer/supplier/market interactions specific industries. All Prosperity Games{trademark} are unique in that both the game format and the player contributions vary from game to game. This report documents the Future{at}Labs.Prosperity Game{trademark} conducted under the sponsorship of the Industry Advisory Boards of the national labs, the national labs, Lockheed Martin Corporation, and the University of California. Players were drawn from all stakeholders involved including government, industry, labs, and academia. The primary objectives of this game were to: (1) explore ways to optimize the role of the multidisciplinary labs in serving national missions and needs; (2) explore ways to increase collaboration and partnerships among government, laboratories, universities, and industry; and (3) create a network of partnership champions to promote findings and policy options. The deliberations and recommendations of these players provided valuable insights as to the views of this diverse group of decision makers concerning the future of the labs.

  3. Hybrid Reality Lab Capabilities - Video 2

    Science.gov (United States)

    Delgado, Francisco J.; Noyes, Matthew

    2016-01-01

    Our Hybrid Reality and Advanced Operations Lab is developing incredibly realistic and immersive systems that could be used to provide training, support engineering analysis, and augment data collection for various human performance metrics at NASA. To get a better understanding of what Hybrid Reality is, let's go through the two most commonly known types of immersive realities: Virtual Reality, and Augmented Reality. Virtual Reality creates immersive scenes that are completely made up of digital information. This technology has been used to train astronauts at NASA, used during teleoperation of remote assets (arms, rovers, robots, etc.) and other activities. One challenge with Virtual Reality is that if you are using it for real time-applications (like landing an airplane) then the information used to create the virtual scenes can be old (i.e. visualized long after physical objects moved in the scene) and not accurate enough to land the airplane safely. This is where Augmented Reality comes in. Augmented Reality takes real-time environment information (from a camera, or see through window, and places digitally created information into the scene so that it matches with the video/glass information). Augmented Reality enhances real environment information collected with a live sensor or viewport (e.g. camera, window, etc.) with the information-rich visualization provided by Virtual Reality. Hybrid Reality takes Augmented Reality even further, by creating a higher level of immersion where interactivity can take place. Hybrid Reality takes Virtual Reality objects and a trackable, physical representation of those objects, places them in the same coordinate system, and allows people to interact with both objects' representations (virtual and physical) simultaneously. After a short period of adjustment, the individuals begin to interact with all the objects in the scene as if they were real-life objects. The ability to physically touch and interact with digitally created

  4. UbuLab, or pataphysics at the university: Searching for the threshold of articulability

    Directory of Open Access Journals (Sweden)

    Piotr Marecki

    2017-10-01

    Full Text Available My proposal runs somewhat counter to the current call for papers for the Journal of Research Cultures on Patainstitutional Research. In my text, I would like to introduce the idea of ​​the pataphysical institution within the structure of the university. I will focus on the UbuLab, founded in 2016, which I am the director of at the Jagiellonian University in Krakow. The UbuLab is a place of experimental software, which operates in the field of ​​creative computing and experimental writing and humanities. This is a place where we work together with digital media theorists, artists and programers. We have also developed a collection of personal computers (from the 1980s till today, especially those platforms that were important for Central and Eastern Europe. One of our main goals is to produce digital work in the context of the university and to study the creative processes in the digital era. This place was modelled on several similar institutions at universities in the United States: The Trope Tank (MIT Media Archeology Lab (the University of Colorado, Boulder, Computer Club (Carnegie Mellon. I participated in internships at all these institutions as a Postdoc (MIT and Visiting Professor. My text will therefore begin with a discussion about these institutions and recall passages from interviews with the directors of these laboratories in which they discuss the design of such a lab. In the next section I will focus on my own experiences with the development of the humanities lab with the participation of artists in the structure of the Polish university, where similar projects have not been implemented. On the one hand, I will focus on completed projects, artistic works, their presentations (for example, during demoparties and achievements; on the other hand, I will showcase institutional problems (lack of meeting places and space, research development, monstrous bureaucracy. In this section, I compare this with my 17 years of experience

  5. Verification of space weather forecasts at the UK Met Office

    Science.gov (United States)

    Bingham, S.; Sharpe, M.; Jackson, D.; Murray, S.

    2017-12-01

    The UK Met Office Space Weather Operations Centre (MOSWOC) has produced space weather guidance twice a day since its official opening in 2014. Guidance includes 4-day probabilistic forecasts of X-ray flares, geomagnetic storms, high-energy electron events and high-energy proton events. Evaluation of such forecasts is important to forecasters, stakeholders, model developers and users to understand the performance of these forecasts and also strengths and weaknesses to enable further development. Met Office terrestrial near real-time verification systems have been adapted to provide verification of X-ray flare and geomagnetic storm forecasts. Verification is updated daily to produce Relative Operating Characteristic (ROC) curves and Reliability diagrams, and rolling Ranked Probability Skill Scores (RPSSs) thus providing understanding of forecast performance and skill. Results suggest that the MOSWOC issued X-ray flare forecasts are usually not statistically significantly better than a benchmark climatological forecast (where the climatology is based on observations from the previous few months). By contrast, the issued geomagnetic storm activity forecast typically performs better against this climatological benchmark.

  6. A Novel Use of Wikipedia in the Instruction of Introduction Physics Labs for Non-majors

    Science.gov (United States)

    Erickson, Nathan

    2010-03-01

    Over the past 2 years, I have incorporated the use of Wikipedia entries into the conclusion sections of the students' lab reports for an introductory physics I laboratory course. The goal of this inclusion is to give students further motivation to learn the knowledge was well as allow the students to bring their knowledge of physics from a memorization schema to a deeper and more fundamental understanding. I will provide initial feedback from students which indicates that this simple cross-disciplinary addition has helped with motivation while exciting a more robust understanding of course material.

  7. Cesarean Sections

    Science.gov (United States)

    ... time. They'll get smaller and become a natural skin color in the weeks and months after delivery. And because incisions are often made in the "bikini" area, many C-section scars aren't even noticeable. What If I Don't Feel Better? Call your health care provider if you have: a fever signs of ...

  8. Telemetry Monitoring and Display Using LabVIEW

    Science.gov (United States)

    Wells, George; Baroth, Edmund C.

    1993-01-01

    The Measurement Technology Center of the Instrumentation Section configures automated data acquisition systems to meet the diverse needs of JPL's experimental research community. These systems are based on personal computers or workstations (Apple, IBM/Compatible, Hewlett-Packard, and Sun Microsystems) and often include integrated data analysis, visualization and experiment control functions in addition to data acquisition capabilities. These integrated systems may include sensors, signal conditioning, data acquisition interface cards, software, and a user interface. Graphical programming is used to simplify configuration of such systems. Employment of a graphical programming language is the most important factor in enabling the implementation of data acquisition, analysis, display and visualization systems at low cost. Other important factors are the use of commercial software packages and off-the-shelf data acquisition hardware where possible. Understanding the experimenter's needs is also critical. An interactive approach to user interface construction and training of operators is also important. One application was created as a result of a competative effort between a graphical programming language team and a text-based C language programming team to verify the advantages of using a graphical programming language approach. With approximately eight weeks of funding over a period of three months, the text-based programming team accomplished about 10% of the basic requirements, while the Macintosh/LabVIEW team accomplished about 150%, having gone beyond the original requirements to simulate a telemetry stream and provide utility programs. This application verified that using graphical programming can significantly reduce software development time. As a result of this initial effort, additional follow-on work was awarded to the graphical programming team.

  9. Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.

    Directory of Open Access Journals (Sweden)

    Sameer A Greenall

    Full Text Available The c-MET receptor has a function in many human cancers and is a proven therapeutic target. Generating antagonistic or therapeutic monoclonal antibodies (mAbs targeting c-MET has been difficult because bivalent, intact anti-Met antibodies frequently display agonistic activity, necessitating the use of monovalent antibody fragments for therapy. By using a novel strategy that included immunizing with cells expressing c-MET, we obtained a range of mAbs. These c-MET mAbs were tested for binding specificity and anti-tumor activity using a range of cell-based techniques and in silico modeling. The LMH 80 antibody bound an epitope, contained in the small cysteine-rich domain of c-MET (amino acids 519-561, that was preferentially exposed on the c-MET precursor. Since the c-MET precursor is only expressed on the surface of cancer cells and not normal cells, this antibody is potentially tumor specific. An interesting subset of our antibodies displayed profound activities on c-MET internalization and degradation. LMH 87, an antibody binding the loop connecting strands 3d and 4a of the 7-bladed β-propeller domain of c-MET, displayed no intrinsic agonistic activity but promoted receptor internalization and degradation. LMH 87 inhibited HGF/SF-induced migration of SK-OV-3 ovarian carcinoma cells, the proliferation of A549 lung cancer cells and the growth of human U87MG glioma cells in a mouse xenograft model. These results indicate that c-MET antibodies targeting epitopes controlling receptor internalization and degradation provide new ways of controlling c-MET expression and activity and may enable the therapeutic targeting of c-MET by intact, bivalent antibodies.

  10. Higher Levels of c-Met Expression and Phosphorylation Identify Cell Lines With Increased Sensitivity to AMG-458, a Novel Selective c-Met Inhibitor With Radiosensitizing Effects

    International Nuclear Information System (INIS)

    Li Bo; Torossian, Artour; Sun, Yunguang; Du, Ruihong; Dicker, Adam P.; Lu Bo

    2012-01-01

    Purpose: c-Met is overexpressed in some non-small cell lung cancer (NSCLC) cell lines and tissues. Cell lines with higher levels of c-Met expression and phosphorylation depend on this receptor for survival. We studied the effects of AMG-458 on 2 NSCLC cell lines. Methods and Materials: 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl) -2H-tetrazolium assays assessed the sensitivities of the cells to AMG-458. Clonogenic survival assays illustrated the radiosensitizing effects of AMG-458. Western blot for cleaved caspase 3 measured apoptosis. Immunoblotting for c-Met, phospho-Met (p-Met), Akt/p-Akt, and Erk/p-Erk was performed to observe downstream signaling. Results: AMG-458 enhanced radiosensitivity in H441 but not in A549. H441 showed constitutive phosphorylation of c-Met. A549 expressed low levels of c-Met, which were phosphorylated only in the presence of exogenous hepatocyte growth factor. The combination of radiation therapy and AMG-458 treatment was found to synergistically increase apoptosis in the H441 cell line but not in A549. Radiation therapy, AMG-458, and combination treatment were found to reduce p-Akt and p-Erk levels in H441 but not in A549. H441 became less sensitive to AMG-458 after small interfering RNA knockdown of c-Met; there was no change in A549. After overexpression of c-Met, A549 became more sensitive, while H441 became less sensitive to AMG-458. Conclusions: AMG-458 was more effective in cells that expressed higher levels of c-Met/p-Met, suggesting that higher levels of c-Met and p-Met in NSCLC tissue may classify a subset of tumors that are more sensitive to molecular therapies against this receptor.

  11. OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

    DEFF Research Database (Denmark)

    Fiil, Berthe Katrine; Damgaard, Rune Busk; Wagner, Sebastian Alexander

    2013-01-01

    Conjugation of Met1-linked polyubiquitin (Met1-Ub) by the linear ubiquitin chain assembly complex (LUBAC) is an important regulatory modification in innate immune signaling. So far, only few Met1-Ub substrates have been described, and the regulatory mechanisms have remained elusive. We recently...... spontaneously accumulated Met1-Ub on LUBAC components, and NOD2 or TNFR1 stimulation led to extensive Met1-Ub accumulation on receptor complex components. We propose that OTULIN restricts Met1-Ub formation after immune receptor stimulation to prevent unwarranted proinflammatory signaling....

  12. PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells

    International Nuclear Information System (INIS)

    Crosswell, Hal E; Dasgupta, Anindya; Alvarado, Carlos S; Watt, Tanya; Christensen, James G; De, Pradip; Durden, Donald L; Findley, Harry W

    2009-01-01

    c-Met is a tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), and both c-Met and its ligand are expressed in a variety of tissues. C-Met/HGF/SF signaling is essential for normal embryogenesis, organogenesis, and tissue regeneration. Abnormal c-Met/HGF/SF signaling has been demonstrated in different tumors and linked to aggressive and metastatic tumor phenotypes. In vitro and in vivo studies have demonstrated inhibition of c-Met/HGF/SF signaling by the small-molecule inhibitor PHA665752. This study investigated c-Met and HGF expression in two neuroblastoma (NBL) cell lines and tumor tissue from patients with NBL, as well as the effects of PHA665752 on growth and motility of NBL cell lines. The effect of the tumor suppressor protein PTEN on migration and proliferation of tumor cells treated with PHA665752 was also evaluated. Expression of c-Met and HGF in NBL cell lines SH-EP and SH-SY5Y and primary tumor tissue was assessed by immunohistochemistry and quantitative RT-PCR. The effect of PHA665752 on c-Met/HGF signaling involved in NBL cell proliferation and migration was evaluated in c-Met-positive cells and c-Met-transfected cells. The transwell chemotaxis assay and the MTT assay were used to measure migration and proliferation/cell-survival of tumor cells, respectively. The PPAR-γ agonist rosiglitazone was used to assess the effect of PTEN on PHA665752-induced inhibition of NBL cell proliferation/cell-survival and migration High c-Met expression was detected in SH-EP cells and primary tumors from patients with advanced-stage disease. C-Met/HGF signaling induced both migration and proliferation of SH-EP cells. Migration and proliferation/cell-survival were inhibited by PHA665752 in a dose-dependent manner. We also found that induced overexpression of PTEN following treatment with rosiglitazone significantly enhanced the inhibitory effect of PHA665752 on NBL-cell migration and proliferation. c-Met is highly expressed in most tumors from

  13. Engineering students' experiences from physics group work in learning labs

    Science.gov (United States)

    Strøm Mellingsæter, Magnus

    2014-01-01

    Background: This paper presents a case study from a physics course at a Norwegian university college, investigating key aspects of a group-work project, so-called learning labs, from the participating students' perspective. Purpose: In order to develop these learning labs further, the students' perspective is important. Which aspects are essential for how the students experience the learning labs, and how do these aspects relate to the emergence of occurrences termed joint workspace, i.e. the maintenance of content-related dialogues within the group? Programme description: First year mechanical engineering students attended the learning labs as a compulsory part of the physics course. The student groups were instructed to solve physics problems using the interactive whiteboard and then submit their work as whiteboard files. Sample: One group of five male students was followed during their work in these learning labs through one term. Design and methods: Data were collected as video recordings and fieldwork observation. In this paper, a focus group interview with the students was the main source of analysis. The interpretations of the interview data were compared with the video material and the fieldwork observations. Results: The results show that the students' overall experience with the learning labs was positive. They did, however, point to internal aspects of conflicting common and personal goals, which led to a group-work dynamics that seemed to inhibit elaborate discussions and collaboration. The students also pointed to external aspects, such as a close temporal proximity between lectures and exercises, which also seemed to inhibit occurrences termed joint workspace. Conclusions: In order to increase the likelihood of a joint workspace throughout the term in the learning labs, careful considerations have to be made with regard to timing between lectures and exercises, but also with regard to raising the students' awareness about shared and personal goals.

  14. Flare forecasting at the Met Office Space Weather Operations Centre

    Science.gov (United States)

    Murray, S. A.; Bingham, S.; Sharpe, M.; Jackson, D. R.

    2017-04-01

    The Met Office Space Weather Operations Centre produces 24/7/365 space weather guidance, alerts, and forecasts to a wide range of government and commercial end-users across the United Kingdom. Solar flare forecasts are one of its products, which are issued multiple times a day in two forms: forecasts for each active region on the solar disk over the next 24 h and full-disk forecasts for the next 4 days. Here the forecasting process is described in detail, as well as first verification of archived forecasts using methods commonly used in operational weather prediction. Real-time verification available for operational flare forecasting use is also described. The influence of human forecasters is highlighted, with human-edited forecasts outperforming original model results and forecasting skill decreasing over longer forecast lead times.

  15. The MeteoMet2 project—highlights and results

    Science.gov (United States)

    Merlone, A.; Sanna, F.; Beges, G.; Bell, S.; Beltramino, G.; Bojkovski, J.; Brunet, M.; del Campo, D.; Castrillo, A.; Chiodo, N.; Colli, M.; Coppa, G.; Cuccaro, R.; Dobre, M.; Drnovsek, J.; Ebert, V.; Fernicola, V.; Garcia-Benadí, A.; Garcia-Izquierdo, C.; Gardiner, T.; Georgin, E.; Gonzalez, A.; Groselj, D.; Heinonen, M.; Hernandez, S.; Högström, R.; Hudoklin, D.; Kalemci, M.; Kowal, A.; Lanza, L.; Miao, P.; Musacchio, C.; Nielsen, J.; Nogueras-Cervera, M.; Oguz Aytekin, S.; Pavlasek, P.; de Podesta, M.; Rasmussen, M. K.; del-Río-Fernández, J.; Rosso, L.; Sairanen, H.; Salminen, J.; Sestan, D.; Šindelářová, L.; Smorgon, D.; Sparasci, F.; Strnad, R.; Underwood, R.; Uytun, A.; Voldan, M.

    2018-02-01

    Launched in 2011 within the European Metrology Research Programme (EMRP) of EURAMET, the joint research project ‘MeteoMet’—Metrology for Meteorology—is the largest EMRP consortium; national metrology institutes, universities, meteorological and climate agencies, research institutes, collaborators and manufacturers are working together, developing new metrological techniques, as well as improving existing ones, for use in meteorological observations and climate records. The project focuses on humidity in the upper and surface atmosphere, air temperature, surface and deep-sea temperatures, soil moisture, salinity, permafrost temperature, precipitation, and the snow albedo effect on air temperature. All tasks are performed using a rigorous metrological approach and include the design and study of new sensors, new calibration facilities, the investigation of sensor characteristics, improved techniques for measurements of essential climate variables with uncertainty evaluation, traceability, laboratory proficiency and the inclusion of field influencing parameters, long-lasting measurements, and campaigns in remote and extreme areas. The vision for MeteoMet is to take a step further towards establishing full data comparability, coherency, consistency, and long-term continuity, through a comprehensive evaluation of the measurement uncertainties for the quantities involved in the global climate observing systems and the derived observations. The improvement in quality of essential climate variables records, through the inclusion of measurement uncertainty budgets, will also highlight possible strategies for the reduction of the uncertainty. This contribution presents selected highlights of the MeteoMet project and reviews the main ongoing activities, tasks and deliverables, with a view to its possible future evolution and extended impact.

  16. Recursos minerais não-metálicos

    Directory of Open Access Journals (Sweden)

    Arlei Benedito Macedo

    1998-08-01

    Full Text Available OS RECURSOS minerais não-metálicos, embora muito importantes para o atendimento das necessidades da população e para o comércio exterior, são pouco contemplados pelas ações governamentais e ignorados pelo público. Geralmente não-incluída no planejamento territorial, a mineração de não-metálicos no Brasil causa extensos impactos ambientais mal controlados. Propõe-se uma ação coordenada de fomento e controle patrimonial e ambiental da mineração, que só será conseguida por ação política, a qual depende da formação abrangente dos profissionais da mineração e de sua maior comunicação com a totalidade da população.NONMETALLIC mineral resources, albeit very important for the needs of the population and for exportation, are ill-favored by governmental actions and ignored by the public. Generally not included in territorial planning, the mining of nonmetallic minerals in Brazil produces extensive, ill-controlled environmental impacts. A coordinated action of promotion and control, both patrimonial and environmental of mining, is proposed. This will only be achieved by political action, which depends on a more comprehensive education of mining professionals and on a greater communication by them with the population as a whole.

  17. C-terminal truncated forms of Met, the hepatocyte growth factor receptor.

    Science.gov (United States)

    Prat, M; Crepaldi, T; Gandino, L; Giordano, S; Longati, P; Comoglio, P

    1991-12-01

    The MET proto-oncogene encodes a transmembrane tyrosine kinase of 190 kDa (p190MET), which has recently been identified as the receptor for hepatocyte growth factor/scatter factor. p190MET is a heterodimer composed of two disulfide-linked chains of 50 kDa (p50 alpha) and 145 kDa (p145 beta). We have produced four different monoclonal antibodies that are specific for the extracellular domain of the Met receptor. These antibodies immunoprecipitate with p190MET two additional Met proteins of 140 and 130 kDa. The first protein (p140MET) is membrane bound and is composed of an alpha chain (p50 alpha) and an 85-kDa C-terminal truncated beta chain (p85 beta). The second protein (p130MET) is released in the culture supernatant and consists of an alpha chain (p50 alpha) and a 75-kDa C-terminal truncated beta chain (p75 beta). Both truncated forms lack the tyrosine kinase domain. p140MET and p130MET are consistently detected in vivo, together with p190MET, in different cell lines or their culture supernatants. p140MET is preferentially localized at the cell surface, where it is present in roughly half the amount of p190MET. The two C-terminal truncated forms of the Met receptor are also found in stable transfectants expressing the full-length MET cDNA, thus showing that they originate from posttranslational proteolysis. This process is regulated by protein kinase C activation. Together, these data suggest that the production of the C-terminal truncated Met forms may have a physiological role in modulating the Met receptor function.

  18. c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target

    International Nuclear Information System (INIS)

    Ozawa, Yohei; Nakamura, Yasuhiro; Fujishima, Fumiyoshi; Felizola, Saulo JA; Takeda, Kenichiro; Okamoto, Hiroshi; Ito, Ken; Ishida, Hirotaka; Konno, Takuro; Kamei, Takashi; Miyata, Go; Ohuchi, Noriaki; Sasano, Hironobu

    2015-01-01

    c-Met is widely known as a poor prognostic factor in various human malignancies. Previous studies have suggested the involvement of c-Met and/or its ligand, hepatocyte growth factor (HGF), in esophageal squamous cell carcinoma (ESCC), but the correlation between c-Met status and clinical outcome remains unclear. Furthermore, the identification of a novel molecular therapeutic target might potentially help improve the clinical outcome of ESCC patients. The expression of c-Met and HGF was immunohistochemically assessed in 104 surgically obtained tissue specimens. The correlation between c-Met/HGF expression and patients’ clinicopathological features, including survival, was evaluated. We also investigated changes in cell functions and protein expression of c-Met and its downstream signaling pathway components under treatments with HGF and/or c-Met inhibitor in ESCC cell lines. Elevated expression of c-Met was significantly correlated with tumor depth and pathological stage. Patients with high c-Met expression had significantly worse survival. In addition, multivariate analysis identified the high expression of c-Met as an independent prognostic factor. Treatment with c-Met inhibitor under HGF stimulation significantly inhibited the invasive capacity of an ESCC cell line with elevated c-Met mRNA expression. Moreover, c-Met and its downstream signaling inactivation was also detected after treatment with c-Met inhibitor. The results of our study identified c-Met expression as an independent prognostic factor in ESCC patients and demonstrated that c-Met could be a potential molecular therapeutic target for the treatment of ESCC with elevated c-Met expression. The online version of this article (doi:10.1186/s12885-015-1450-3) contains supplementary material, which is available to authorized users

  19. Prevalence of metabolic syndrome in patients with rheumatoid arthritis in Morocco: a cross-sectional study of 179 cases.

    Science.gov (United States)

    Abourazzak, Fatima Ezzahra; Mansouri, Samia; Najdi, Adil; Tahiri, Latifa; Nejjari, Chakib; Harzy, Taoufik

    2014-11-01

    Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular disease (CVD). The prevalence of metabolic syndrome (MetS)-a major contributor to CVD-in RA seems to be increased, suggesting that systemic inflammation and antirheumatic therapy may contribute to its presence. We aimed to determine the prevalence of MetS in RA, to identify the potential factors associated with its presence, and to evaluate the influence of antirheumatic drugs on the occurrence of MetS in a cohort of Moroccan patients with RA. The prevalence of MetS was assessed cross-sectionally in 179 patients with RA over a period of 17 months (July 2011-December 2012). Three definitions of MetS were used (National Cholesterol Education Program/Adult Treatment Panel III 2005, International Diabetes Federation 2005, and American Association of Clinical Endocrinologists 2003). All statistical analyses were done using the SPSS software version 18.0. Multivariate logistic regression model was constructed to identify independent predictors of MetS in patients with RA. The prevalence of MetS in RA varied from 24.6 to 30.7 % according to the definitions used. In a multivariate logistic regression model, the severity of RA and less methotrexate use were identified as significant independent predictors of the presence of MetS in RA patients. Our study suggests that MetS is common among Moroccan patients with severe RA. Methotrexate therapy was identified as an independent factor associated with a reduced risk of having MetS in these patients, suggesting a drug-specific mechanism and making methotrexate a first-line disease-modifying antirheumatic drug in RA patients who are at high risk of developing MetS.

  20. A Conceptual Review of Lab-Based Aggression Paradigms

    Directory of Open Access Journals (Sweden)

    Randy J. McCarthy

    2018-01-01

    Full Text Available Aggression is often defined as a behavior that is done with the intent to harm an individual who is believed to want avoid being harmed (e.g., Baron & Richardson, 1994. Accordingly, social scientists have developed several tasks to study aggression in laboratory settings; tasks that we refer to as “lab-based aggression paradigms.” However, because of the legal, ethical, and practical issues inherent in provoking aggression within the confines of a laboratory setting, it is feasible to study only very mildly harmful aggression. The current conceptual review examines the criteria that are necessary to study aggression in a laboratory setting, discusses the strengths and weaknesses of several new and/or commonly-used lab-based aggression paradigms, and offers recommendations for the future of lab-based aggression research. Collectively, we hope the current discussion helps researchers to describe the contributions and limitations of lab-based aggression research and, ultimately, helps to improve the informativeness of lab-based aggression research.

  1. Lab-on-a-chip pathogen sensors for food safety.

    Science.gov (United States)

    Yoon, Jeong-Yeol; Kim, Bumsang

    2012-01-01

    There have been a number of cases of foodborne illness among humans that are caused by pathogens such as Escherichia coli O157:H7, Salmonella typhimurium, etc. The current practices to detect such pathogenic agents are cell culturing, immunoassays, or polymerase chain reactions (PCRs). These methods are essentially laboratory-based methods that are not at all real-time and thus unavailable for early-monitoring of such pathogens. They are also very difficult to implement in the field. Lab-on-a-chip biosensors, however, have a strong potential to be used in the field since they can be miniaturized and automated; they are also potentially fast and very sensitive. These lab-on-a-chip biosensors can detect pathogens in farms, packaging/processing facilities, delivery/distribution systems, and at the consumer level. There are still several issues to be resolved before applying these lab-on-a-chip sensors to field applications, including the pre-treatment of a sample, proper storage of reagents, full integration into a battery-powered system, and demonstration of very high sensitivity, which are addressed in this review article. Several different types of lab-on-a-chip biosensors, including immunoassay- and PCR-based, have been developed and tested for detecting foodborne pathogens. Their assay performance, including detection limit and assay time, are also summarized. Finally, the use of optical fibers or optical waveguide is discussed as a means to improve the portability and sensitivity of lab-on-a-chip pathogen sensors.

  2. MetNetAPI: A flexible method to access and manipulate biological network data from MetNet

    Directory of Open Access Journals (Sweden)

    Sucaet Yves

    2010-11-01

    Full Text Available Abstract Background Convenient programmatic access to different biological databases allows automated integration of scientific knowledge. Many databases support a function to download files or data snapshots, or a webservice that offers "live" data. However, the functionality that a database offers cannot be represented in a static data download file, and webservices may consume considerable computational resources from the host server. Results MetNetAPI is a versatile Application Programming Interface (API to the MetNetDB database. It abstracts, captures and retains operations away from a biological network repository and website. A range of database functions, previously only available online, can be immediately (and independently from the website applied to a dataset of interest. Data is available in four layers: molecular entities, localized entities (linked to a specific organelle, interactions, and pathways. Navigation between these layers is intuitive (e.g. one can request the molecular entities in a pathway, as well as request in what pathways a specific entity participates. Data retrieval can be customized: Network objects allow the construction of new and integration of existing pathways and interactions, which can be uploaded back to our server. In contrast to webservices, the computational demand on the host server is limited to processing data-related queries only. Conclusions An API provides several advantages to a systems biology software platform. MetNetAPI illustrates an interface with a central repository of data that represents the complex interrelationships of a metabolic and regulatory network. As an alternative to data-dumps and webservices, it allows access to a current and "live" database and exposes analytical functions to application developers. Yet it only requires limited resources on the server-side (thin server/fat client setup. The API is available for Java, Microsoft.NET and R programming environments and offers

  3. Antibaryon Photoproduction using CLAS at Jefferson Lab

    Science.gov (United States)

    Phelps, William; CLAS Collaboration

    2017-09-01

    There is little known about the baryon-antibaryon photoproduction mechanism. Three reactions, γp -> pp p , γp -> pp n π- , and γp -> pn p π+ have been investigated for the photon energy range of 3.95-5.45 GeV. The data were from the g12 experiment taken with the CLAS detector using a liquid hydrogen target in Hall B at Thomas Jefferson National Accelerator Facility. This experiment had high statistics, with an integrated luminosity of 68 pb-1. General features of the data and preliminary cross sections for the p p system will be discussed.

  4. Die era van Suid-Afrika se militere hoogbloei met die ...

    African Journals Online (AJOL)

    -. Afrikaanse inmenging in .... Yaaldriehoekers is oak met die begrip die 'totale aanslag' teen Suid-Afrika bekend gemaak.26 Met die ..... Anon, "White flee violent Vaal Triangle", in Vaal Ster, 21-25 Feb 1994. Dagboek, J. Bergh ...

  5. An Analysis of the HEU-MET-FAST-035 Problem Using CENTRM and SCALE

    International Nuclear Information System (INIS)

    Hollenbach, D.F.; Jordan, W.C.

    1999-01-01

    An U/Fe benchmark, designated as HEU-MET-FAST-035, has been approved for inclusion in the International Handbook of Evaluated Criticality Safety Benchmark Experiments. The SCALE code and cross sections performed poorly in calculating this critical experiment. Deficiencies in both the ENDF/B-V representation of the resonance region for Fe and in the Nordheim integral treatment when applied to Fe were identified. The combination of these deficiencies led to an almost 10% over-prediction of k(eff). Problems involving a large percentage of Fe and intermediate-energy spectrums present special cross-section processing difficulties for SCALE. In ENDF/B-V, resonance data for Fe only go to 400 keV, although resonances are present well above 1 MeV. Significant resonance data are stored as file 3 data instead of as resonance parameters. The Nordheim Integral Treatment used in NITAWL to process cross sections assume: resonances are widely spaced and all relevant information is contained in the resonance parameters (file 3 data is not processed). These limitations and assumptions result in poor solutions for this class of problems

  6. RiskLab - a joint Teaching Lab on Hazard and Risk Management

    Science.gov (United States)

    Baruffini, Mi.; Baruffini, Mo.; Thuering, M.

    2009-04-01

    In the future natural disasters are expected to increase due to climatic changes that strongly affect environmental, social and economical systems. For this reason and because of the limited resources, governments require analytical risk analysis for a better mitigation planning. Risk analysis is a process to determine the nature and extent of risk by estimating potential hazards and evaluating existing conditions of vulnerability that could pose a potential threat or harm to people, property, livelihoods and environment. This process has become a generally accepted approach for the assessment of cost-benefit scenarios; originating from technical risks it is being applied to natural hazards for several years now in Switzerland. Starting from these premises "Risk Lab", a joint collaboration between the Institute of Earth Sciences of the University of Applied Sciences of Southern Switzerland and the Institute for Economic Research of the University of Lugano, has been started in 2006, aiming to become a competence centre about Risk Analysis and Evaluation. The main issue studied by the lab concerns the topic "What security at what price?" and the activities follow the philosophy of the integral risk management as proposed by PLANAT, that defines the process as a cycle that contains different and interrelated phases. The final aim is to change the population and technician idea about risk from "defending against danger" to "being aware of risks" through a proper academic course specially addressed to young people. In fact the most important activity of the laboratory consists in a degree course, offered both to Engineering and Architecture students of the University of Applied Sciences of Southern Switzerland and Economy Students of the University of Lugano. The course is structured in two main parts: an introductive, theoretical part, composed by class lessons, where the main aspects of natural hazards, risk perception and evaluation and risk management are presented

  7. Kids are not little adults: what MET threshold captures sedentary behavior in children?

    Science.gov (United States)

    Saint-Maurice, Pedro F; Kim, Youngwon; Welk, Gregory J; Gaesser, Glenn A

    2016-01-01

    The study compares MET-defined cutpoints used to classify sedentary behaviors in children using a simulated free-living design. A sample of 102 children (54 boys and 48 girls; 7-13 years) completed a set of 12 activities (randomly selected from a pool of 24 activities) in a random order. Activities were predetermined and ranged from sedentary to vigorous intensities. Participant's energy expenditure was measured using a portable indirect calorimetry system, Oxycon mobile. Measured minute-by-minute VO2 values (i.e., ml/kg/min) were converted to an adult- or child-MET value using the standard 3.5 ml/kg/min or the estimated child resting metabolic rate, respectively. Classification agreement was examined for both the "standard" (1.5 adult-METs) and an "adjusted" (2.0 adult-METs) MET-derived threshold for classifying sedentary behavior. Alternatively, we also tested the classification accuracy of a 1.5 child-MET threshold. Classification accuracy of sedentary activities was evaluated relative to the predetermined intensity categorization using receiver operator characteristic curves. There were clear improvements in the classification accuracy for sedentary activities when a threshold of 2.0 adult-METs was used instead of 1.5 METs (Se1.5 METs = 4.7%, Sp1.5 METs = 100.0%; Se2.0 METs = 36.9%, Sp2.0 METs = 100.0 %). The use of child-METs while maintaining the 1.5 threshold also resulted in improvements in classification (Se = 45.1%, Sp = 100.0%). Adult-MET thresholds are not appropriate for children when classifying sedentary activities. Classification accuracy for identifying sedentary activities was improved when either an adult-MET of 2.0 or a child-MET of 1.5 was used.

  8. Lab-scale Technology for Biogas Production from Lignocellulose Wastes

    Directory of Open Access Journals (Sweden)

    Lukáš Krátký

    2012-01-01

    Full Text Available Currently-operating biogas plants are based on the treatment of lignocellulose biomass, which is included in materials such as agriculture and forestry wastes, municipal solid wastes, waste paper, wood and herbaceous energy crops. Lab-scale biogas technology was specially developed for evaluating the anaerobic biodegrability and the specific methane yields of solid organic substrates. This technology falls into two main categories – pretreatment equipments, and fermentation equipments. Pretreatment units use physical principles based on mechanical comminution (ball mills, macerator orhydrothermal treatment (liquid hot water pretreatment technology. The biochemical methane potential test is used to evaluate the specific methane yields of treated or non-treated organic substrates. This test can be performed both by lab testing units and by lab fermenter.

  9. Integration of remote lab exercises into standard course packages

    Directory of Open Access Journals (Sweden)

    T. Zimmer

    2007-08-01

    Full Text Available We propose to integrate remote lab exercises into standard course packages. A standard course package consists in classroom sessions, exercise sessions and lab sessions, the whole completed by homework for following up and preparing the different sessions. Homework is crucial in the learning process and we have developed a dedicated platform integrating four levels of activities accompanying each lesson. The first level recalls the learning objectives and learning contents of each lesson. The corresponding exercises are proposed in a second level. An auto-evaluation can be done in a third level. Finally, lab exercises are proposed for each topic in the forth level. The whole is organised in a hierarchical tree structure for easy navigation and a good overview.

  10. Living labs design and assessment of sustainable living

    CERN Document Server

    Guerra-Santin, Olivia; Lockton, Dan

    2017-01-01

    This book presents the results of a multi-annual project with sustainable Living Labs in the United Kingdom, Sweden, Germany and the Netherlands. Living Labs – as initiated by the authors – have proved to be very promising research, design, co-creation and communication facilities for the development and implementation of sustainable innovations in the home. The book provides an inspiring introduction to both the methodology and business modelling for the Living Lab facilities. Understanding daily living at home is key to designing products and services that support households in their transition to more sustainable lifestyles. This book not only explores new ways of gaining insights into daily practices, but also discusses developing and testing design methods to create sustainable solutions for households. These new methods and tools are needed because those available are either ineffective or cause rebound-effects. Intended for researchers and designers with an interest in the transition to sustainable...

  11. EUSO@TurLab: An experimental replica of ISS orbits

    Directory of Open Access Journals (Sweden)

    Bertaina M.

    2015-01-01

    Full Text Available The EUSO@TurLab project is an on-going activity aimed to reproduce atmospheric and luminous conditions that JEM-EUSO will encounter on its orbits around the Earth. The use of the TurLab facility, part of the Department of Physics of the University of Torino, allows the simulation of different surface conditions in a very dark and rotating environment in order to test the response of JEM-EUSO's sensors and sensitivity. The experimental setup currently in operation has been used to check the potential of the TurLab facility for the above purposes, and the acquired data will be used to test the concept of JEM-EUSO's trigger system.

  12. Promoting Metacognition in Introductory Calculus-based Physics Labs

    Science.gov (United States)

    Grennell, Drew; Boudreaux, Andrew

    2010-10-01

    In the Western Washington University physics department, a project is underway to develop research-based laboratory curriculum for the introductory calculus-based course. Instructional goals not only include supporting students' conceptual understanding and reasoning ability, but also providing students with opportunities to engage in metacognition. For the latter, our approach has been to scaffold reflective thinking with guided questions. Specific instructional strategies include analysis of alternate reasoning presented in fictitious dialogues and comparison of students' initial ideas with their lab group's final, consensus understanding. Assessment of student metacognition includes pre- and post- course data from selected questions on the CLASS survey, analysis of written lab worksheets, and student opinion surveys. CLASS results are similar to a traditional physics course and analysis of lab sheets show that students struggle to engage in a metacognitive process. Future directions include video studies, as well as use of additional written assessments adapted from educational psychology.

  13. Lab-on-a-chip technologies for stem cell analysis.

    Science.gov (United States)

    Ertl, Peter; Sticker, Drago; Charwat, Verena; Kasper, Cornelia; Lepperdinger, Günter

    2014-05-01

    The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of analyzing cell cultures under physiologically relevant conditions. In the present review, we address recent lab-on-a-chip developments for stem cell analysis. We highlight in particular the tangible advantages of microfluidic devices to overcome most of the challenges associated with stem cell identification, expansion and differentiation, with the greatest advantage being that lab-on-a-chip technology allows for the precise regulation of culturing conditions, while simultaneously monitoring relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of stem cell cultures are presented and their potential future applications discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Lab on a chip technologies for algae detection: a review.

    Science.gov (United States)

    Schaap, Allison; Rohrlack, Thomas; Bellouard, Yves

    2012-08-01

    Over the last few decades, lab on a chip technologies have emerged as powerful tools for high-accuracy diagnosis with minute quantities of liquid and as tools for exploring cell properties in general. In this paper, we present a review of the current status of this technology in the context of algae detection and monitoring. We start with an overview of the detection methods currently used for algae monitoring, followed by a review of lab on a chip devices for algae detection and classification, and then discuss a case study based on our own research activities. We conclude with a discussion on future challenges and motivations for algae-oriented lab on a chip technologies. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer.

    Science.gov (United States)

    Song, Na; Qu, Xiujuan; Liu, Shizhou; Zhang, Simeng; Liu, Jing; Qu, Jinglei; Zheng, Huachuan; Liu, Yunpeng; Che, Xiaofang

    2017-08-01

    Hepatocyte growth factor (HGF)/MET signaling is implicated in the development of colorectal cancer (CRC) and possesses therapeutic value for various types of cancer. However, inhibition of MET alone has been demonstrated to have limited efficacy. The present study examined the combined inhibition of MET and SRC kinase activity in colon cancer cells. Furthermore, the role of the HGF/MET pathway in ligand-dependent and -independent activation was demonstrated. The single inhibition of MET by knockdown small interfering RNA or inhibitor indicated a limited anti-viability effects without inhibiting the basal phosphorylation levels of SRC, protein kinase B (AKT) or extracellular signal-regulated kinase (ERK). In view of the strong association between MET and SRC identified by direct regulation, growth factor-induced MET activation was suppressed by pretreatment with the SRC inhibitor, dasatinib, and downstream phosphorylation of AKT and ERK partially decreased, which suggested that SRC activation was essential for ligand-dependent and -independent activation of MET. Considering that both the activation of MET and SRC was required in ligand-dependent and -independent MET activation, the antitumor effect of concurrent inhibition of MET and SRC was examined, and it was demonstrated that combination treatment exerted increased viability inhibition and apoptosis enhancement in mutant and wild type RAS colon cancer cells. Therefore, combinational inhibition of MET and SRC may be a promising strategy for the treatment of CRC.

  16. Samen opgespoord? : Eindrapport "Pilot samenwerking particuliere onderzoeksbureaus met politie en OM"

    NARCIS (Netherlands)

    Friperson, R.; Bouman, S.; Wilms, P.

    2013-01-01

    In samenwerking met de Nederlandse Veiligheidsbranche (NV) is een pilot ingericht met als doel na te gaan welke rol particuliere onderzoeksbureau's (POB’s) kunnen spelen bij de opsporing in strafzaken. De pilot heeft plaatsgevonden tussen 1 mei 2012 tot en met 3o april 2013. Aan de pilot namen negen

  17. Examination of mobile phones in a university forensic lab environment

    Science.gov (United States)

    Luttenberger, Silas; Kröger, Knut; Creutzburg, Reiner

    2011-06-01

    The aim of this article is to show forensic investigation methods for mobile phones to students in a university forensic lab environment. Students have to learn the usefulness of forensic procedures to ensure evidence collection, evidence preservation, forensic analysis, and reporting. Open source tools as well as commercial forensic tools for forensic investigation of modern mobile (smart) phones are used. It is demonstrated how important data stored in the mobile device are investigated. Different scenarios of investigations are presented that are well-suited for forensics lab work in university.

  18. Touch-enabled Programming for the Lab of Things

    OpenAIRE

    Dong, Zheng; Samuel, Arjmand

    2013-01-01

    Lab of Things (LoT, lab-of-things.com) is a research platform for interconnection, programming, and large scale deployment of devices and sensors. These devices and sensors can then be used for deployment of field studies in a variety of research areas including elderly care, energy management, and the like. LoT is built on top of HomeOS, a middle-ware component, making interconnection of a wide range of devices possible. LoT also provides cloud storage and remote monitoring capabilities. Tra...

  19. An Overview of Dark Matter Experiments at Jefferson Lab

    International Nuclear Information System (INIS)

    Boyce, James R

    2012-01-01

    Dark Matter research at Jefferson Lab started in 2006 with the LIght Pseudoscalar and Scalar Search (LIPSS) collaboration to check the validity of results reported by the PVLAS collaboration. In the intervening years interest in dark matter laboratory experiments has grown at Jefferson Lab. Current research underway or in planning stages probe various mass regions covering 14 orders of magnitude: from 10 −6 eV to 100 MeV. This presentation will be an overview of our dark matter searches, three of which focus on the hypothesized A' gauge boson.

  20. NASA Dryden: Flight Loads Lab Capabilities and Mass Properties Testing

    Science.gov (United States)

    Wolfe, David Michael; Bakalyar, John A.

    2011-01-01

    This presentation covers the basic capabilities of the Dryden Flight Loads Lab. It also covers in detail the mass properties capabilities of the loads lab, focusing on the recent mass properties testing of the X-48B, and the recent tests of the Dynamic Inertia Measurement method (DIMM). Presentation focuses on the test methods and issues discovered during the mass properties testing of the X-48B leading to the requirement of new instrumentation on all conventional mass properties testing. Presentation also focuses on development of DIMM for replacement of conventional mass properties tests.

  1. Design and Evaluation of an Instructional Solar Energy Technologies Lab

    Directory of Open Access Journals (Sweden)

    Christina B. Class

    2011-09-01

    Full Text Available This paper presents a design for a solar energy lab that allows students to plan, install and evaluate different system architectures and gain relevant practical experiences. The addressed learning outcomes are analyzed based on the 13 learning outcomes defined by the Accreditation Board for Engineering and Technology (ABET as well as based on the taxonomy levels of the cognitive domain after Bloom. In this paper we present a sample lab assignment and map its tasks to the learning outcomes and cognitive domains. First results of qualitative student feedback are equally presented.

  2. Innovative Use of a Classroom Response System During Physics Lab

    Science.gov (United States)

    Walgren, Jay

    2011-01-01

    More and more physics instructors are making use of personal/classroom response systems or "clickers." The use of clickers to engage students with multiple-choice questions during lecture and available instructor resources for clickers have been well documented in this journal.1-4 Newer-generation clickers, which I refer to as classroom response systems (CRS), have evolved to accept numeric answers (such as 9.81) instead of just single "multiple-choice" entries (Fig. 1). This advancement is available from most major clicker companies and allows for a greater variety of engaging questions during lecture. In addition, these new "numeric ready" clickers are marketed to be used for student assessments. During a test or quiz, students' answers are entered into their clicker instead of on paper or Scantron® and immediately absorbed by wireless connection into a computer for grading and analysis. I recognize the usefulness and benefit these new-generation CRSs provide for many instructors. However, I do not use my CRS in either of the aforementioned activities. Instead, I use it in an unconventional way. I use the CRS to electronically capture students' lab data as they are performing a physics lab (Fig. 2). I set up the clickers as if I were going to use them for a test, but instead of entering answers to a test, my students enter lab data as they collect it. In this paper I discuss my use of a classroom response system during physics laboratory and three benefits that result: 1) Students are encouraged to "take ownership of" and "have integrity with" their physics lab data. 2) Students' measuring and unit conversion deficiencies are identified immediately during the lab. 3) The process of grading students' labs is simplified because the results of each student's lab calculations can be pre-calculated for the instructor using a spreadsheet. My use of clickers during lab can be implemented with most clicker systems available to instructors today. The CRS I use is the e

  3. Integrated lasers for polymer Lab-on-a-Chip systems

    DEFF Research Database (Denmark)

    Mappes, Timo; Vannahme, Christoph; Grosmann, Tobias

    2012-01-01

    We develop optical Lab-on-a-Chips on different platforms for marker-based and label-free biophotonic sensor applications. Our chips are based on polymers and fabricated by mass production technologies to integrate microfluidic channels, optical waveguides and miniaturized lasers.......We develop optical Lab-on-a-Chips on different platforms for marker-based and label-free biophotonic sensor applications. Our chips are based on polymers and fabricated by mass production technologies to integrate microfluidic channels, optical waveguides and miniaturized lasers....

  4. Professional penetration testing creating and operating a formal hacking lab

    CERN Document Server

    Wilhelm, Thomas

    2009-01-01

    PART I - Setting Up. Chapter 1: Introduction. Chapter 2: Ethics and Hacking. Chapter 3: Hacking as a Career. Chapter 4: Setting up Your Lab. Chapter 5: Creating and Using PenTest Targets in Your Lab. Chapter 6: Methodologies. Chapter 7: PenTest Metrics. Chapter 8: Management of a PenTest. PART II - Running a PenTest. Chapter 9: Information Gathering. Chapter 10: Vulnerability Identification. Chapter 11: Vulnerability Verification. Chapter 12: Compromising a System and Privilege Escalation. Chapter 13: Maintaining Access. Chapter 14: Covering Your Tracks. PART III - Wrapping Everything Up. Chap

  5. Collarín para soportes metálicos

    Directory of Open Access Journals (Sweden)

    de Miguel, J. L.

    1998-10-01

    Full Text Available In architectural works, structural calculations are usually few and simple, they mostly corroborate what is already known. Calculations are made for the most part with the purpose of exploring solutions. When working in a specific case operations ought to be framed in the practical understanding, with predictable values and tabulated solutions, with no surprises. To write numbers and trust them blindly, is like a reckless appointment, something that should not be done in structures. This article shows how to use the structural knowledge in order to explore a specific solution: a collar for metal supports.

    En las obras de arquitectura los cálculos estructurales suelen ser pocos y sencillos, más bien para corroborar algo que se sabía de antemano. Los números se hacen, en su mayor parte, para explorar soluciones; cuando se trabaja en un caso particular debe operarse en un marco conocido, con valores predictables y soluciones tabuladas, sin sorpresas. Hacer números para fiarse a pies juntillas de ellos, es como una cita a ciegas, algo no recomendable en estructuras. Este artículo muestra cómo usar los conocimientos estructurales para explorar una solución: la de un collarín para soportes metálicos.

  6. Mecanismo cognitivos en la memoria; la Metáfora

    Directory of Open Access Journals (Sweden)

    Francisco José Ruiz de Mendoza Ibañez

    2010-12-01

    Full Text Available La Lingüística Cognitiva (LC es una disciplina que, pese a su juventud, ha experimentado un desarrollo vertiginoso en los últimos treinta años1. Uno de los mayores logros de la LC (que la distingue de enfoques anteriores sobre el lenguaje como el estructuralismo y el generativismo chomskyano radica en no considerar el lenguaje como un sistema autosuficiente, sino más bien como una facultad cognitiva que interactúa con otras capacidades como son la percepción, la atención, la memoria, la emoción y el razonamiento. Por tanto, en LC los significados son parte de nuestro mundo conceptual. En la versión más temprana de la TMC Lakoff y Johnson defienden que tanto el lenguaje como el pensamiento están ligados y se estructuran de acuerdo con la experiencia corpórea (embodied experience. Así, la experiencia perceptual y espacial es la base para la categorización del mundo de manera que estas categorías (que pertenecen a dominios concretos se hacen corresponder con dominios más abstractos como los de la emoción, el tiempo o la estructura. Por tanto, la metáfora queda definida como un conjunto de correspondencias (conceptual mapping entre un dominio fuente (más concreto y un dominio meta (más abstracto.

  7. 40 CFR 80.1338 - What criteria must be met to qualify as a small refiner for the gasoline benzene requirements of...

    Science.gov (United States)

    2010-07-01

    ... as a small refiner for the gasoline benzene requirements of this subpart? 80.1338 Section 80.1338... FUELS AND FUEL ADDITIVES Gasoline Benzene Small Refiner Provisions § 80.1338 What criteria must be met to qualify as a small refiner for the gasoline benzene requirements of this subpart? (a) A small...

  8. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

    DEFF Research Database (Denmark)

    Sehested, Astrid Marie

    2016-01-01

    fusions activated mitogen-activated protein kinase (MAPK) signaling and, in cooperation with lesions compromising cell cycle regulation, induced aggressive glial tumors in vivo. MET inhibitors suppressed MET tumor growth in xenograft models. Finally, we treated a pediatric patient bearing a MET-fusion......Pediatric glioblastoma is one of the most common and most deadly brain tumors in childhood. Using an integrative genetic analysis of 53 pediatric glioblastomas and five in vitro model systems, we identified previously unidentified gene fusions involving the MET oncogene in ∼10% of cases. These MET...

  9. c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.

    Science.gov (United States)

    Granito, Alessandro; Guidetti, Elena; Gramantieri, Laura

    2015-01-01

    c-MET is the membrane receptor for hepatocyte growth factor (HGF), also known as scatter factor or tumor cytotoxic factor, a mitogenic growth factor for hepatocytes. HGF is mainly produced by cells of mesenchymal origin and it mainly acts on neighboring epidermal and endothelial cells, regulating epithelial growth and morphogenesis. HGF/MET signaling has been identified among the drivers of tumorigenesis in human cancers. As such, c-MET is a recognized druggable target, and against it, targeted agents are currently under clinical investigation. c-MET overexpression is a common event in a wide range of human malignancies, including gastric, lung, breast, ovary, colon, kidney, thyroid, and liver carcinomas. Despite c-MET overexpression being reported by a large majority of studies, no evidence for a c-MET oncogenic addiction exists in hepatocellular carcinoma (HCC). In particular, c-MET amplification is a rare event, accounting for 4%-5% of cases while no mutation has been identified in c-MET oncogene in HCC. Thus, the selection of patient subgroups more likely to benefit from c-MET inhibition is challenging. Notwithstanding, c-MET overexpression was reported to be associated with increased metastatic potential and poor prognosis in patients with HCC, providing a rationale for its therapeutic inhibition. Here we summarize the role of activated HGF/MET signaling in HCC, its prognostic relevance, and the implications for therapeutic approaches in HCC.

  10. c-Met and Other Cell Surface Molecules: Interaction, Activation and Functional Consequences

    Directory of Open Access Journals (Sweden)

    Giuditta Viticchiè

    2015-01-01

    Full Text Available The c-Met receptor, also known as the HGF receptor, is one of the most studied tyrosine kinase receptors, yet its biological functions and activation mechanisms are still not fully understood. c-Met has been implicated in embryonic development and organogenesis, in tissue remodelling homeostasis and repair and in cancer metastasis. These functions are indicative of the many cellular processes in which the receptor plays a role, including cell motility, scattering, survival and proliferation. In the context of malignancy, sustained activation of c-Met leads to a signalling cascade involving a multitude of kinases that initiate an invasive and metastatic program. Many proteins can affect the activation of c-Met, including a variety of other cell surface and membrane-spanning molecules or receptors. Some cell surface molecules share structural homology with the c-Met extracellular domain and can activate c-Met via clustering through this domain (e.g., plexins, whereas other receptor tyrosine kinases can enhance c-Met activation and signalling through intracellular signalling cascades (e.g., EGFR. In this review, we provide an overview of c-Met interactions and crosstalk with partner molecules and the functional consequences of these interactions on c-Met activation and downstream signalling, c-Met intracellular localization/recycling and c-Met degradation.

  11. MET targeted therapy for lung cancer: clinical development and future directions

    Directory of Open Access Journals (Sweden)

    Feng Y

    2012-08-01

    Full Text Available Yan Feng,1,2 Patrick C Ma1–31Translational Hematology and Oncology Research, 2Solid Tumor Oncology, 3Aerodigestive Oncology Translational Research, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USAAbstract: MET, the receptor for hepatocyte growth factor, has been identified as a novel promising target in various human malignancies, including lung cancer. Research studies have demonstrated that MET signaling plays important physiologic roles in embryogenesis and early development, whereas its deregulation from an otherwise quiescent signaling state in mature adult tissues can lead to upregulated cell proliferation, survival, scattering, motility and migration, angiogenesis, invasion, and metastasis in tumorigenesis and tumor progression. The MET pathway can be activated through ligand (hepatocyte growth factor, HGF or MET receptor overexpression, genomic amplification, MET mutations, and alternative splicing. A number of novel therapeutic agents that target the MET/hepatocyte growth factor pathway have been tested in early-phase clinical studies with promising results. Phase III studies of MET targeting agents have recently been initiated. This paper will review the MET signaling pathway and biology in lung cancer, and the recent clinical development and advances of MET/hepatocyte growth factor targeting agents. Emphasis will be placed on discussing various unanswered issues and key strategies needed to optimize further clinical development of MET targeting personalized lung cancer therapy.Keywords: MET, HGF, lung cancer, targeted therapy

  12. K+ nucleus total cross sections

    International Nuclear Information System (INIS)

    Sawafta, R.

    1990-01-01

    The scattering of K + mesons from nuclei has attracted considerable interest in the last few years. The K + holds a very special position as the weakest of all strongly interaction probes. The average cross section is not larger than about 10 mb at lab momenta below 800 MeV/c, corresponding to a mean free path in the nucleus larger than 5 fm. Thus the K + is capable of probing the entire volume of the nucleus. Single scattering of the K + with a nucleon in the nucleus dominates the nuclear scattering, and only small and calculable higher order corrections are needed. The nucleon is a dynamical entity and its internal structure can, in principle, be altered by its surrounding nuclear environment. This work reports an experiment in which the K + is used to compare the nucleon in the nucleus with a free nucleon

  13. An interview with the president. "I'd like to see America used as a global lab".

    Science.gov (United States)

    Clinton, W J

    2000-12-22

    AN INTERVIEW WITH THE PRESIDENT:"I'd Like to See America Used as a Global Lab" President Bill Clinton met with Science magazine on 6 December for a broad-ranging interview that looked at how science and technology are likely to change our world, and how he might continue to interact with the scientific community after he leaves office in January. What emerged confirms a portrait many people have painted of Clinton: a polymath who rarely resorts to the platitudes we have come to expect from politicians--especially on the topic of science. This online transcript of the conversation between Clinton and Science Editor Ellis Rubinstein contains material which could not be included in print for space reasons.

  14. Ionic Liquids and Green Chemistry: A Lab Experiment

    Science.gov (United States)

    Stark, Annegret; Ott, Denise; Kralisch, Dana; Kreisel, Guenter; Ondruschka, Bernd

    2010-01-01

    Although ionic liquids have been investigated as solvents for many applications and are starting to be used in industrial processes, only a few lab experiments are available to introduce students to these materials. Ionic liquids have been discussed in the context of green chemistry, but few investigations have actually assessed the degree of…

  15. ThinkSpace: Spatial Thinking in Middle School Astronomy Labs

    Science.gov (United States)

    Udomprasert, Patricia S.; Goodman, Alyssa A.; Plummer, Julia; Sadler, Philip M.; Johnson, Erin; Sunbury, Susan; Zhang, Helen; Dussault, Mary E.

    2016-01-01

    Critical breakthroughs in science (e.g., Einstein's Theory of General Relativity, and Watson & Crick's discovery of the structure of DNA), originated with those scientists' ability to think spatially, and research has shown that spatial ability correlates strongly with likelihood of entering a career in STEM. Mounting evidence also shows that spatial skills are malleable, i.e., they can be improved through training. We report early work from a new project that will build on this research to create a series of middle schools science labs called "Thinking Spatially about the Universe" (ThinkSpace), in which students will use a blend of physical and virtual models (in WorldWide Telescope) to explore complex 3-dimensional phenomena in space science. In the three-year ThinkSpace labs project, astronomers, technologists, and education researchers are collaborating to create and test a suite of three labs designed to improve learners' spatial abilities through studies of: 1) Moon phases and eclipses; 2) planetary systems around stars other than the Sun; and 3.) celestial motions within the broader universe. The research program will determine which elements in the labs will best promote improvement of spatial skills within activities that emphasize disciplinary core ideas; and how best to optimize interactive dynamic visualizations to maximize student understanding.

  16. The Jefferson Lab 12 GeV Program

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, Hugh [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2017-04-19

    The Jefferson Lab facilities have undergone a substantial upgrade, both of accelerator, CEBAF, and of the experimental installations. We will discuss the progress to completion of these facilities, the status of accelerator commissioning, and the recent first operations for physics. We will then flesh out the anticipated exciting physics program of the next several years.

  17. Head first: Living labs for ad-hoc search evaluation

    NARCIS (Netherlands)

    Balog, K.; Kelly, L.; Schuth, A.; Li, J.; Wang, X.S.

    2014-01-01

    The information retrieval (IR) community strives to make evaluation more centered on real users and their needs. The living labs evaluation paradigm, i.e., observing users in their natural task environments, offers great promise in this regard. Yet, progress in an academic setting has been limited.

  18. SHORT REPORT Practical considerations in planning a cath-lab ...

    African Journals Online (AJOL)

    This room hosts the C-arm power supply cabinets, as well as X-ray tube heat converters and any other computer hardware necessary for the vascular lab. The control room should be state of the art with huge glass windows that overlook the vascular laboratory so that effective handling of software occurs during a procedure.

  19. Fungal Culture Test: MedlinePlus Lab Test Information

    Science.gov (United States)

    ... Tools Español You Are Here: Home → Lab Test Information → Fungal Culture Test URL of this page: https://medlineplus.gov/ ... of Wisconsin Hospitals and Clinics Authority; c2017. Health Information: Fungal Culture for Athlete's Foot: Exam Overview [updated 2016 Oct ...

  20. Fermentation art and science at the Nordic Food Lab

    DEFF Research Database (Denmark)

    Reade, Benedict; de Valicourt, Justine; Evans, Joshua David

    2015-01-01

    The Nordic Food Lab (NFL) is a self-governed foundation based in Copenhagen, Denmark. The aim of NFL is to investigate food diversity and deliciousness and to share the results in an open-source format. We combine scientific and cultural approaches with culinary techniques from around the world...