WorldWideScience

Sample records for meanings semantic toxicological

  1. Gricean Semantics and Vague Speaker-Meaning

    OpenAIRE

    Schiffer, Stephen

    2017-01-01

    Presentations of Gricean semantics, including Stephen Neale’s in “Silent Reference,” totally ignore vagueness, even though virtually every utterance is vague. I ask how Gricean semantics might be adjusted to accommodate vague speaker-meaning. My answer is that it can’t accommodate it: the Gricean program collapses in the face of vague speaker-meaning. The Gricean might, however, fi nd some solace in knowing that every other extant meta-semantic and semantic program is in the same boat.

  2. Semantics, pragmatics and the theory of meaning

    NARCIS (Netherlands)

    Groenendijk, J.A.G.; Stokhof, M.J.B.

    1978-01-01

    In this paper arguments are given for the thesis that an adequate theory of meaning for a natural language has to consist at least of a recursive specification of the truth conditions (semantics) and of a recursive specification of the correctness conditions (pragmatics) of the sentences of that

  3. A Semantic Basis for Meaning Construction in Constructivist Interactions

    DEFF Research Database (Denmark)

    Badie, Farshad

    2015-01-01

    . In this research I will analyse 'meaning construction' within constructivism. I will focus on a semantic loop that the learner and mentor as intentional participants move through and organise their personal constructed conceptions in order to construct meanings and produce their individual meaningful...... comprehensions. Subsequently, I will provide a semantic framework for analysing the meaning construction based on personal knowings and personal conceptions within constructivist interactions. This research could propose a new scheme for interpretation based on semantics and on interaction....

  4. Principal semantic components of language and the measurement of meaning.

    Science.gov (United States)

    Samsonovich, Alexei V; Samsonovic, Alexei V; Ascoli, Giorgio A

    2010-06-11

    Metric systems for semantics, or semantic cognitive maps, are allocations of words or other representations in a metric space based on their meaning. Existing methods for semantic mapping, such as Latent Semantic Analysis and Latent Dirichlet Allocation, are based on paradigms involving dissimilarity metrics. They typically do not take into account relations of antonymy and yield a large number of domain-specific semantic dimensions. Here, using a novel self-organization approach, we construct a low-dimensional, context-independent semantic map of natural language that represents simultaneously synonymy and antonymy. Emergent semantics of the map principal components are clearly identifiable: the first three correspond to the meanings of "good/bad" (valence), "calm/excited" (arousal), and "open/closed" (freedom), respectively. The semantic map is sufficiently robust to allow the automated extraction of synonyms and antonyms not originally in the dictionaries used to construct the map and to predict connotation from their coordinates. The map geometric characteristics include a limited number ( approximately 4) of statistically significant dimensions, a bimodal distribution of the first component, increasing kurtosis of subsequent (unimodal) components, and a U-shaped maximum-spread planar projection. Both the semantic content and the main geometric features of the map are consistent between dictionaries (Microsoft Word and Princeton's WordNet), among Western languages (English, French, German, and Spanish), and with previously established psychometric measures. By defining the semantics of its dimensions, the constructed map provides a foundational metric system for the quantitative analysis of word meaning. Language can be viewed as a cumulative product of human experiences. Therefore, the extracted principal semantic dimensions may be useful to characterize the general semantic dimensions of the content of mental states. This is a fundamental step toward a

  5. Principal semantic components of language and the measurement of meaning.

    Directory of Open Access Journals (Sweden)

    Alexei V Samsonovich

    Full Text Available Metric systems for semantics, or semantic cognitive maps, are allocations of words or other representations in a metric space based on their meaning. Existing methods for semantic mapping, such as Latent Semantic Analysis and Latent Dirichlet Allocation, are based on paradigms involving dissimilarity metrics. They typically do not take into account relations of antonymy and yield a large number of domain-specific semantic dimensions. Here, using a novel self-organization approach, we construct a low-dimensional, context-independent semantic map of natural language that represents simultaneously synonymy and antonymy. Emergent semantics of the map principal components are clearly identifiable: the first three correspond to the meanings of "good/bad" (valence, "calm/excited" (arousal, and "open/closed" (freedom, respectively. The semantic map is sufficiently robust to allow the automated extraction of synonyms and antonyms not originally in the dictionaries used to construct the map and to predict connotation from their coordinates. The map geometric characteristics include a limited number ( approximately 4 of statistically significant dimensions, a bimodal distribution of the first component, increasing kurtosis of subsequent (unimodal components, and a U-shaped maximum-spread planar projection. Both the semantic content and the main geometric features of the map are consistent between dictionaries (Microsoft Word and Princeton's WordNet, among Western languages (English, French, German, and Spanish, and with previously established psychometric measures. By defining the semantics of its dimensions, the constructed map provides a foundational metric system for the quantitative analysis of word meaning. Language can be viewed as a cumulative product of human experiences. Therefore, the extracted principal semantic dimensions may be useful to characterize the general semantic dimensions of the content of mental states. This is a fundamental step

  6. Forms of encoded pragmatic meaning: semantic prosody. A lexicographic perspective.

    Directory of Open Access Journals (Sweden)

    Mojca Šorli

    2014-03-01

    Full Text Available Abstract – The present paper focuses on ways in which the pragmatic (functional meaning that arises from various contextual features, known in corpus linguistics as semantic prosody (Sinclair 1996, 2004; Louw 1993, etc. can become an integral part of lexicographic descriptions. This is especially important for the treatment of phraseology and idiomatics. The workings of semantic prosody are a good example of the ways pragmatic meaning exploits linguistic means to be codified in the text. We thus investigate the meaning that can only be studied in context, as it is completely dependent on collocation, i.e., syntagmatic relations, and therefore cannot be attributed solely to a concrete word form. Corpus analysis has yielded significant results in areas such as the lexicographic treatment of semantic prosody. We believe that in order to improve teaching pragmatics in all its complexity, it is necessary to recognise and assess various aspects of pragmatic meaning both in written and spoken language. Second/foreign language teaching/learning in particular has been strongly dependent on the inclusion of relevant information in dictionaries, in which, traditionally, pragmatic aspects of meaning have been largely neglected. Language technologies have enabled us both to study the subtleties of pragmatic meaning and to design accurate and more user-friendly (pedagogical dictionaries. We will attempt to demonstrate the value of explicit description of functional pragmatic meaning, i.e. semantic prosody, as implemented in the Slovene Lexical Database (2008-2012. A brief overview of the theoretical background is first provided, after which we describe the definition strategies employed to include pragmatics, as well as presenting a case study and arguing that explicating semantic prosody is crucial in developing pragmatic competence in (young/foreign language learners. Keywords: semantic prosody; pragmatics; lexicographic description; dictionary; lexical

  7. Taxonomies, Folksonomies, and Semantics: Establishing Functional Meaning in Navigational Structures

    Science.gov (United States)

    Bacha, Jeffrey A.

    2012-01-01

    This article argues for the establishment of a usability process that incorporates the study of "words" and "word phrases." It demonstrates how semantically mapping a navigational taxonomy can help the developers of digital environments establish a more focused sense of functional meaning for the users of their digital designs.

  8. Personal Experience and Arithmetic Meaning in Semantic Dementia

    Science.gov (United States)

    Julien, Camille L.; Neary, David; Snowden, Julie S.

    2010-01-01

    Arithmetic skills are generally claimed to be preserved in semantic dementia (SD), suggesting functional independence of arithmetic knowledge from other aspects of semantic memory. However, in a recent case series analysis we showed that arithmetic performance in SD is not entirely normal. The finding of a direct association between severity of…

  9. OpenTox predictive toxicology framework: toxicological ontology and semantic media wiki-based OpenToxipedia.

    Science.gov (United States)

    Tcheremenskaia, Olga; Benigni, Romualdo; Nikolova, Ivelina; Jeliazkova, Nina; Escher, Sylvia E; Batke, Monika; Baier, Thomas; Poroikov, Vladimir; Lagunin, Alexey; Rautenberg, Micha; Hardy, Barry

    2012-04-24

    The OpenTox Framework, developed by the partners in the OpenTox project (http://www.opentox.org), aims at providing a unified access to toxicity data, predictive models and validation procedures. Interoperability of resources is achieved using a common information model, based on the OpenTox ontologies, describing predictive algorithms, models and toxicity data. As toxicological data may come from different, heterogeneous sources, a deployed ontology, unifying the terminology and the resources, is critical for the rational and reliable organization of the data, and its automatic processing. The following related ontologies have been developed for OpenTox: a) Toxicological ontology - listing the toxicological endpoints; b) Organs system and Effects ontology - addressing organs, targets/examinations and effects observed in in vivo studies; c) ToxML ontology - representing semi-automatic conversion of the ToxML schema; d) OpenTox ontology- representation of OpenTox framework components: chemical compounds, datasets, types of algorithms, models and validation web services; e) ToxLink-ToxCast assays ontology and f) OpenToxipedia community knowledge resource on toxicology terminology.OpenTox components are made available through standardized REST web services, where every compound, data set, and predictive method has a unique resolvable address (URI), used to retrieve its Resource Description Framework (RDF) representation, or to initiate the associated calculations and generate new RDF-based resources.The services support the integration of toxicity and chemical data from various sources, the generation and validation of computer models for toxic effects, seamless integration of new algorithms and scientifically sound validation routines and provide a flexible framework, which allows building arbitrary number of applications, tailored to solving different problems by end users (e.g. toxicologists). The OpenTox toxicological ontology projects may be accessed via the Open

  10. Teaching Semantic Radicals Facilitates Inferring New Character Meaning in Sentence Reading for Nonnative Chinese Speakers

    Directory of Open Access Journals (Sweden)

    Thi Phuong Nguyen

    2017-10-01

    Full Text Available This study investigates the effects of teaching semantic radicals in inferring the meanings of unfamiliar characters among nonnative Chinese speakers. A total of 54 undergraduates majoring in Chinese Language from a university in Hanoi, Vietnam, who had 1 year of learning experience in Chinese were assigned to two experimental groups that received instructional intervention, called “old-for-new” semantic radical teaching, through two counterbalanced sets of semantic radicals, with one control group. All of the students completed pre- and post-tests of a sentence cloze task where they were required to choose an appropriate character that fit the sentence context among four options. The four options shared the same phonetic radicals but had different semantic radicals. The results showed that the pre-test and post-test score increases were significant for the experimental groups, but not for the control group. Most importantly, the experimental groups successfully transferred the semantic radical strategy to figure out the meanings of unfamiliar characters containing semantic radicals that had not been taught. The results demonstrate the effectiveness of teaching semantic radicals for lexical inference in sentence reading for nonnative speakers, and highlight the ability of transfer learning to acquire semantic categories of sub-lexical units (semantic radicals in Chinese characters among foreign language learners.

  11. of Geoffrey Leech's Semantics: the Study of Meaning

    African Journals Online (AJOL)

    ings of units of form (e.g. 'words'), together with rules governing the semantic ... who has before him Harrap's French-English, English-French dictionary as his sale ..... The second distinction is between 'conceptual' ('literal ') and other kinds of ...

  12. Vection is modulated by the semantic meaning of stimuli and experimental instructions.

    Science.gov (United States)

    Ogawa, Masaki; Seno, Takeharu

    2014-01-01

    Vection strength is modulated by the semantic meanings of stimuli. In experiment 1--even though vection stimuli were of uniform size, color, and luminance--when they also had semantic meaning as falling objects, vection was inhibited. Specifically, stimuli perceived as feathers, petals, and leaves did not effectively induce vection. In experiment 2 we used the downward motion of identical dots to induce vection. Participants observed stimuli while holding either an umbrella or a wooden sword. Results showed that vection was inhibited when participants held the umbrella and the stimuli was perceived as rain or snow falling. The two experiments suggest that vection is modulated by the semantic meaning of stimuli.

  13. Toxicological evaluation of Cd-based fluorescent nanoprobes by means of in vivo studies

    Science.gov (United States)

    Farias, Patricia M. A.; Ma-Hock, Lan; Landsiedel, Robert; van Ravenzwaay, Bennard

    2018-02-01

    Cadmium still represents a stigma for many research- and/or industrial applications. Some deleterious effects are attributed to Cadmium. In the present work, highly fluorescent Cadmium sulfide quantum dots are investigated by e.g. physical-chemical characterization. Most important however is their application as fluorescent probes for bio-imaging in living cells and tissues. This work presents their toxicological evaluation by means of in vivo studies. Bio-imaging experiments are performed without any pre-treatment. The toxicological studies performed, strongly indicate that the use of Cadmium based nanoparticles as fluorescent probes may be nonhazardous and not induce side effects for cells/tissues.

  14. Semantic Ambiguity: Do Multiple Meanings Inhibit or Facilitate Word Recognition?

    Science.gov (United States)

    Haro, Juan; Ferré, Pilar

    2018-06-01

    It is not clear whether multiple unrelated meanings inhibit or facilitate word recognition. Some studies have found a disadvantage for words having multiple meanings with respect to unambiguous words in lexical decision tasks (LDT), whereas several others have shown a facilitation for such words. In the present study, we argue that these inconsistent findings may be due to the approach employed to select ambiguous words across studies. To address this issue, we conducted three LDT experiments in which we varied the measure used to classify ambiguous and unambiguous words. The results suggest that multiple unrelated meanings facilitate word recognition. In addition, we observed that the approach employed to select ambiguous words may affect the pattern of experimental results. This evidence has relevant implications for theoretical accounts of ambiguous words processing and representation.

  15. The semantics of prosody: acoustic and perceptual evidence of prosodic correlates to word meaning.

    Science.gov (United States)

    Nygaard, Lynne C; Herold, Debora S; Namy, Laura L

    2009-01-01

    This investigation examined whether speakers produce reliable prosodic correlates to meaning across semantic domains and whether listeners use these cues to derive word meaning from novel words. Speakers were asked to produce phrases in infant-directed speech in which novel words were used to convey one of two meanings from a set of antonym pairs (e.g., big/small). Acoustic analyses revealed that some acoustic features were correlated with overall valence of the meaning. However, each word meaning also displayed a unique acoustic signature, and semantically related meanings elicited similar acoustic profiles. In two perceptual tests, listeners either attempted to identify the novel words with a matching meaning dimension (picture pair) or with mismatched meaning dimensions. Listeners inferred the meaning of the novel words significantly more often when prosody matched the word meaning choices than when prosody mismatched. These findings suggest that speech contains reliable prosodic markers to word meaning and that listeners use these prosodic cues to differentiate meanings. That prosody is semantic suggests a reconceptualization of traditional distinctions between linguistic and nonlinguistic properties of spoken language. Copyright © 2009 Cognitive Science Society, Inc.

  16. Statistical means to enhance the comparability of data within a pooled analysis of individual data in neurobehavioral toxicology

    DEFF Research Database (Denmark)

    Meyer-Baron, Monika; Schäper, Michael; Knapp, Guido

    2011-01-01

    Meta-analyses of individual participant data (IPD) provide important contributions to toxicological risk assessments. However, comparability of individual data cannot be taken for granted when information from different studies has to be summarized. By means of statistical standardization...

  17. Anesthesiology Journal club assessment by means of semantic changes.

    Science.gov (United States)

    Vieira, Joaquim Edson; Torres, Marcelo Luís Abramides; Pose, Regina Albanese; Auler, José Otávio Costa Junior

    2014-01-01

    the interactive approach of a journal club has been described in the medical education literature. The aim of this investigation is to present an assessment of journal club as a tool to address the question whether residents read more and critically. this study reports the performance of medical residents in anesthesiology from the Clinics Hospital - University of São Paulo Medical School. All medical residents were invited to answer five questions derived from discussed papers. The answer sheet consisted of an affirmative statement with a Likert type scale (totally disagree-disagree-not sure-agree-totally agree), each related to one of the chosen articles. The results were evaluated by means of item analysis - difficulty index and discrimination power. residents filled one hundred and seventy three evaluations in the months of December 2011 (n=51), July 2012 (n=66) and December 2012 (n=56). The first exam presented all items with straight statement, second and third exams presented mixed items. Separating "totally agree" from "agree" increased the difficulty indices, but did not improve the discrimination power. the use of a journal club assessment with straight and inverted statements and by means of five points scale for agreement has been shown to increase its item difficulty and discrimination power. This may reflect involvement either with the reading or the discussion during the journal meeting. Copyright © 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

  18. Neural Semantic Parsing by Character-based Translation: Experiments with Abstract Meaning Representations

    NARCIS (Netherlands)

    van Noord, Rik; Bos, Johannes

    2017-01-01

    We evaluate the character-level translation method for neural semantic parsing on a large corpus of sentences annotated with Abstract Meaning Representations (AMRs). Using a sequence-to-sequence model, and some trivial preprocessing and postprocessing of AMRs, we obtain a baseline accuracy of 53.1

  19. Identifying Meaning Components in the Translation of Medical Terms from English into Indonesian: A Semantic Approach

    Directory of Open Access Journals (Sweden)

    I Gusti Agung Sri Rwa Jayantini

    2017-10-01

    Full Text Available This paper focuses on identifying meaning components in the translation of English medical terms into Indonesian. The data used in this study are the English medical term disorder and its Indonesian equivalent penyakit (disease. The two terms are purposively chosen as the data of the present study, which is a comparative research on the lexical meaning investigation in two different languages. The investigation involving a particular term in one language and its equivalent in the other language is worth doing since the lexicons in every language have their own specific concepts that may be synonymous, yet they are not always interchangeable in all contexts. The analysis into meaning components is called decomposition by means of several semantic theories to analyse the meaning of a lexical item (Löbner 2013. Here, the meaning components of the two compared terms are demonstrated through a semantic approach, particularly Natural Semantic Metalanguage (NSM supported by the investigation on their synonyms and how the terms are used in different contexts. The results show that the meaning components of a particular term in one language like the English term disorder are not always found in the Indonesian term penyakit, or, conversely, some of the meaning components of the Indonesian term do not always exist in the English term.

  20. Semantic embodiment, disembodiment or misembodiment? In search of meaning in modules and neuron circuits.

    Science.gov (United States)

    Pulvermüller, Friedemann

    2013-10-01

    "Embodied" proposals claim that the meaning of at least some words, concepts and constructions is grounded in knowledge about actions and objects. An alternative "disembodied" position locates semantics in a symbolic system functionally detached from sensorimotor modules. This latter view is not tenable theoretically and has been empirically falsified by neuroscience research. A minimally-embodied approach now claims that action-perception systems may "color", but not represent, meaning; however, such minimal embodiment (misembodiment?) still fails to explain why action and perception systems exert causal effects on the processing of symbols from specific semantic classes. Action perception theory (APT) offers neurobiological mechanisms for "embodied" referential, affective and action semantics along with "disembodied" mechanisms of semantic abstraction, generalization and symbol combination, which draw upon multimodal brain systems. In this sense, APT suggests integrative-neuromechanistic explanations of why both sensorimotor and multimodal areas of the human brain differentially contribute to specific facets of meaning and concepts. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  1. What does it all mean? Capturing Semantics of Surgical Data and Algorithms with Ontologies

    OpenAIRE

    Katić, Darko; Maleshkova, Maria; Engelhardt, Sandy; Wolf, Ivo; März, Keno; Maier-Hein, Lena; Nolden, Marco; Wagner, Martin; Kenngott, Hannes; Müller-Stich, Beat Peter; Dillmann, Rüdiger; Speidel, Stefanie

    2017-01-01

    Every year approximately 234 million major surgeries are performed, leading to plentiful, highly diverse data. This is accompanied by a matching number of novel algorithms for the surgical domain. To garner all benefits of surgical data science it is necessary to have an unambiguous, shared understanding of algorithms and data. This includes inputs and outputs of algorithms and thus their function, but also the semantic content, i.e. meaning of data such as patient parameters. We therefore pr...

  2. Semantic Advertising

    OpenAIRE

    Zamanzadeh, Ben; Ashish, Naveen; Ramakrishnan, Cartic; Zimmerman, John

    2013-01-01

    We present the concept of Semantic Advertising which we see as the future of online advertising. Semantic Advertising is online advertising powered by semantic technology which essentially enables us to represent and reason with concepts and the meaning of things. This paper aims to 1) Define semantic advertising, 2) Place it in the context of broader and more widely used concepts such as the Semantic Web and Semantic Search, 3) Provide a survey of work in related areas such as context matchi...

  3. New comparison of psychological meaning of colors in samples and objects with semantic ratings

    Science.gov (United States)

    Lee, Tien-Rein

    2002-06-01

    In color preference and color-meaning research, color chips are widely used as stimuli. Are meanings of isolated color chips generalizeable to contextualized colors? According to Taft (1996), few significant differences exist between chip and object ratings for the same color. A similar survey was performed on 192 college students. This article reports the results of the study comparing semantic rating of color applied to a variety of familiar objects. The objects were a cup, T-shirt, sofa, car, notebook, and MP3 player, all images that represent daily life familiar objects. Subjects rated a set of 16 color chips, against 6 bipolar, 7-step semantic differential scales. The scales consisted of beautiful-ugly, soft-hard, warm-cool, elegant-vulgar, loud- discreet, and masculine-feminine. Analyses performed on the data indicated that unlike Taft's findings on 1996, significant differences existed between chip and object rating for the same color in every scale. The results of the study have implications for the use of color chips in color planning which suggest they are not compatible with the generality of results of the earlier color meaning research. Generally, a color judged to be beautiful, elegant and warm when presented as a chip does not equal beautiful, elegant, and warm when applied to the surface of an object such as a cup, T-shirt, sofa, car.

  4. Universal Dimensions of Meaning Derived from Semantic Relations among Words and Senses: Mereological Completeness vs. Ontological Generality

    Directory of Open Access Journals (Sweden)

    Alexei V. Samsonovich

    2014-07-01

    Full Text Available A key to semantic analysis is a precise and practically useful definition of meaning that is general for all domains of knowledge. We previously introduced the notion of weak semantic map: a metric space allocating concepts along their most general (universal semantic characteristics while at the same time ignoring other, domain-specific aspects of their meanings. Here we address questions of the number, quality, and mutual independence of the weak semantic dimensions. Specifically, we employ semantic relationships not previously used for weak semantic mapping, such as holonymy/meronymy (“is-part/member-of”, and we compare maps constructed from word senses to those constructed from words. We show that the “completeness” dimension derived from the holonym/meronym relation is independent of, and practically orthogonal to, the “abstractness” dimension derived from the hypernym-hyponym (“is-a” relation, while both dimensions are orthogonal to the maps derived from synonymy and antonymy. Interestingly, the choice of using relations among words vs. senses implies a non-trivial trade-off between rich and unambiguous information due to homonymy and polysemy. The practical utility of the new and prior dimensions is illustrated by the automated evaluation of different kinds of documents. Residual analysis of available linguistic resources, such as WordNet, suggests that the number of universal semantic dimensions representable in natural language may be finite. Their complete characterization, as well as the extension of results to non-linguistic materials, remains an open challenge.

  5. Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R.

    Science.gov (United States)

    Sauer, Ursula G; Wächter, Thomas; Hareng, Lars; Wareing, Britta; Langsch, Angelika; Zschunke, Matthias; Alvers, Michael R; Landsiedel, Robert

    2014-06-01

    The knowledge-based search engine Go3R, www.Go3R.org, has been developed to assist scientists from industry and regulatory authorities in collecting comprehensive toxicological information with a special focus on identifying available alternatives to animal testing. The semantic search paradigm of Go3R makes use of expert knowledge on 3Rs methods and regulatory toxicology, laid down in the ontology, a network of concepts, terms, and synonyms, to recognize the contents of documents. Search results are automatically sorted into a dynamic table of contents presented alongside the list of documents retrieved. This table of contents allows the user to quickly filter the set of documents by topics of interest. Documents containing hazard information are automatically assigned to a user interface following the endpoint-specific IUCLID5 categorization scheme required, e.g. for REACH registration dossiers. For this purpose, complex endpoint-specific search queries were compiled and integrated into the search engine (based upon a gold standard of 310 references that had been assigned manually to the different endpoint categories). Go3R sorts 87% of the references concordantly into the respective IUCLID5 categories. Currently, Go3R searches in the 22 million documents available in the PubMed and TOXNET databases. However, it can be customized to search in other databases including in-house databanks. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. Sharing meanings: developing interoperable semantic technologies to enhance reproducibility in earth and environmental science research

    Science.gov (United States)

    Schildhauer, M.

    2015-12-01

    Earth and environmental scientists are familiar with the entities, processes, and theories germane to their field of study, and comfortable collecting and analyzing data in their area of interest. Yet, while there appears to be consistency and agreement as to the scientific "terms" used to describe features in their data and analyses, aside from a few fundamental physical characteristics—such as mass or velocity-- there can be broad tolerances, if not considerable ambiguity, in how many earth science "terms" map to the underlying "concepts" that they actually represent. This ambiguity in meanings, or "semantics", creates major problems for scientific reproducibility. It greatly impedes the ability to replicate results—by making it difficult to determine the specifics of the intended meanings of terms such as deforestation or carbon flux -- as to scope, composition, magnitude, etc. In addition, semantic ambiguity complicates assemblage of comparable data for reproducing results, due to ambiguous or idiosyncratic labels for measurements, such as percent cover of forest, where the term "forest" is undefined; or where a reported output of "total carbon-emissions" might just include CO2 emissions, but not methane emissions. In this talk, we describe how the NSF-funded DataONE repository for earth and environmental science data (http://dataone.org), is using W3C-standard languages (RDF/OWL) to build an ontology for clarifying concepts embodied in heterogeneous data and model outputs. With an initial focus on carbon cycling concepts using terrestrial biospheric model outputs and LTER productivity data, we describe how we are achieving interoperability with "semantic vocabularies" (or ontologies) from aligned earth and life science domains, including OBO-foundry ontologies such as ENVO and BCO; the ISO/OGC O&M; and the NSF Earthcube GeoLink project. Our talk will also discuss best practices that may be helpful for other groups interested in constructing their own

  7. The semantic representation of event information depends on the cue modality: an instance of meaning-based retrieval.

    Science.gov (United States)

    Karlsson, Kristina; Sikström, Sverker; Willander, Johan

    2013-01-01

    The semantic content, or the meaning, is the essence of autobiographical memories. In comparison to previous research, which has mainly focused on the phenomenological experience and the age distribution of retrieved events, the present study provides a novel view on the retrieval of event information by quantifying the information as semantic representations. We investigated the semantic representation of sensory cued autobiographical events and studied the modality hierarchy within the multimodal retrieval cues. The experiment comprised a cued recall task, where the participants were presented with visual, auditory, olfactory or multimodal retrieval cues and asked to recall autobiographical events. The results indicated that the three different unimodal retrieval cues generate significantly different semantic representations. Further, the auditory and the visual modalities contributed the most to the semantic representation of the multimodally retrieved events. Finally, the semantic representation of the multimodal condition could be described as a combination of the three unimodal conditions. In conclusion, these results suggest that the meaning of the retrieved event information depends on the modality of the retrieval cues.

  8. The semantic representation of event information depends on the cue modality: an instance of meaning-based retrieval.

    Directory of Open Access Journals (Sweden)

    Kristina Karlsson

    Full Text Available The semantic content, or the meaning, is the essence of autobiographical memories. In comparison to previous research, which has mainly focused on the phenomenological experience and the age distribution of retrieved events, the present study provides a novel view on the retrieval of event information by quantifying the information as semantic representations. We investigated the semantic representation of sensory cued autobiographical events and studied the modality hierarchy within the multimodal retrieval cues. The experiment comprised a cued recall task, where the participants were presented with visual, auditory, olfactory or multimodal retrieval cues and asked to recall autobiographical events. The results indicated that the three different unimodal retrieval cues generate significantly different semantic representations. Further, the auditory and the visual modalities contributed the most to the semantic representation of the multimodally retrieved events. Finally, the semantic representation of the multimodal condition could be described as a combination of the three unimodal conditions. In conclusion, these results suggest that the meaning of the retrieved event information depends on the modality of the retrieval cues.

  9. From imitation to meaning: circuit plasticity and the acquisition of a primitive semantics.

    Directory of Open Access Journals (Sweden)

    Ricardo R Garcia

    2014-08-01

    Full Text Available The capacity for language is arguably the most remarkable innovation of the human brain. A relatively recent interpretation prescribes that part of the language-related circuits were co-opted from circuitry involved in hand control –the mirror neuron system, involved both in the perception and in the execution of voluntary grasping actions. A less radical view is that in early humans, communication was opportunistic and multimodal, using signs, vocalizations or whatever means available to transmit social information. However, one point that is not yet clear under either perspective is how learned communication acquired a semantic property thereby allowing us to name objects and eventually describe our surrounding environment. Here we suggest a scenario involving both manual gestures and learned vocalizations that led to the development of a primitive form of conventionalized reference. This proposal is based on comparative evidence gathered from other species and on neurolinguistic evidence in humans, which points to a crucial role for vocal learning in the early development of language. Firstly, the capacity to direct the attention of others to a common object may have been crucial for developing a consensual referential system. Pointing, which is a ritualized grasping gesture, may have been crucial to this end. Vocalizations also served to generate joint attention among conversants, especially when combined with gaze direction. Another contributing element was the development of pantomimic actions resembling events or animals. In conjunction with this mimicry, the development of plastic neural circuits that support complex, learned vocalizations was probably a significant factor in the evolution of conventionalized semantics in our species. Thus, vocal imitations of sounds, as in onomatopoeias (words whose sound resembles their meaning, are possibly supported by mirror system circuits, and may have been relevant in the acquisition of early

  10. From imitation to meaning: circuit plasticity and the acquisition of a conventionalized semantics.

    Science.gov (United States)

    García, Ricardo R; Zamorano, Francisco; Aboitiz, Francisco

    2014-01-01

    The capacity for language is arguably the most remarkable innovation of the human brain. A relatively recent interpretation prescribes that part of the language-related circuits were co-opted from circuitry involved in hand control-the mirror neuron system (MNS), involved both in the perception and in the execution of voluntary grasping actions. A less radical view is that in early humans, communication was opportunistic and multimodal, using signs, vocalizations or whatever means available to transmit social information. However, one point that is not yet clear under either perspective is how learned communication acquired a semantic property thereby allowing us to name objects and eventually describe our surrounding environment. Here we suggest a scenario involving both manual gestures and learned vocalizations that led to the development of a primitive form of conventionalized reference. This proposal is based on comparative evidence gathered from other species and on neurolinguistic evidence in humans, which points to a crucial role for vocal learning in the early development of language. Firstly, the capacity to direct the attention of others to a common object may have been crucial for developing a consensual referential system. Pointing, which is a ritualized grasping gesture, may have been crucial to this end. Vocalizations also served to generate joint attention among conversants, especially when combined with gaze direction. Another contributing element was the development of pantomimic actions resembling events or animals. In conjunction with this mimicry, the development of plastic neural circuits that support complex, learned vocalizations was probably a significant factor in the evolution of conventionalized semantics in our species. Thus, vocal imitations of sounds, as in onomatopoeias (words whose sound resembles their meaning), are possibly supported by mirror system circuits, and may have been relevant in the acquisition of early meanings.

  11. Affective Congruence between Sound and Meaning of Words Facilitates Semantic Decision.

    Science.gov (United States)

    Aryani, Arash; Jacobs, Arthur M

    2018-05-31

    A similarity between the form and meaning of a word (i.e., iconicity) may help language users to more readily access its meaning through direct form-meaning mapping. Previous work has supported this view by providing empirical evidence for this facilitatory effect in sign language, as well as for onomatopoetic words (e.g., cuckoo) and ideophones (e.g., zigzag). Thus, it remains largely unknown whether the beneficial role of iconicity in making semantic decisions can be considered a general feature in spoken language applying also to "ordinary" words in the lexicon. By capitalizing on the affective domain, and in particular arousal, we organized words in two distinctive groups of iconic vs. non-iconic based on the congruence vs. incongruence of their lexical (meaning) and sublexical (sound) arousal. In a two-alternative forced choice task, we asked participants to evaluate the arousal of printed words that were lexically either high or low arousing. In line with our hypothesis, iconic words were evaluated more quickly and more accurately than their non-iconic counterparts. These results indicate a processing advantage for iconic words, suggesting that language users are sensitive to sound-meaning mappings even when words are presented visually and read silently.

  12. Distinctive Features Hold a Privileged Status in the Computation of Word Meaning: Implications for Theories of Semantic Memory

    Science.gov (United States)

    Cree, George S.; McNorgan, Chris; McRae, Ken

    2006-01-01

    The authors present data from 2 feature verification experiments designed to determine whether distinctive features have a privileged status in the computation of word meaning. They use an attractor-based connectionist model of semantic memory to derive predictions for the experiments. Contrary to central predictions of the conceptual structure…

  13. Semantics and the multisensory brain: how meaning modulates processes of audio-visual integration.

    Science.gov (United States)

    Doehrmann, Oliver; Naumer, Marcus J

    2008-11-25

    By using meaningful stimuli, multisensory research has recently started to investigate the impact of stimulus content on crossmodal integration. Variations in this respect have often been termed as "semantic". In this paper we will review work related to the question for which tasks the influence of semantic factors has been found and which cortical networks are most likely to mediate these effects. More specifically, the focus of this paper will be on processing of object stimuli presented in the auditory and visual sensory modalities. Furthermore, we will investigate which cortical regions are particularly responsive to experimental variations of content by comparing semantically matching ("congruent") and mismatching ("incongruent") experimental conditions. In this context, recent neuroimaging studies point toward a possible functional differentiation of temporal and frontal cortical regions, with the former being more responsive to semantically congruent and the latter to semantically incongruent audio-visual (AV) stimulation. To account for these differential effects, we will suggest in the final section of this paper a possible synthesis of these data on semantic modulation of AV integration with findings from neuroimaging studies and theoretical accounts of semantic memory.

  14. Word meaning in the ventral visual path: a perceptual to conceptual gradient of semantic coding.

    Science.gov (United States)

    Borghesani, Valentina; Pedregosa, Fabian; Buiatti, Marco; Amadon, Alexis; Eger, Evelyn; Piazza, Manuela

    2016-12-01

    The meaning of words referring to concrete items is thought of as a multidimensional representation that includes both perceptual (e.g., average size, prototypical color) and conceptual (e.g., taxonomic class) dimensions. Are these different dimensions coded in different brain regions? In healthy human subjects, we tested the presence of a mapping between the implied real object size (a perceptual dimension) and the taxonomic categories at different levels of specificity (conceptual dimensions) of a series of words, and the patterns of brain activity recorded with functional magnetic resonance imaging in six areas along the ventral occipito-temporal cortical path. Combining multivariate pattern classification and representational similarity analysis, we found that the real object size implied by a word appears to be primarily encoded in early visual regions, while the taxonomic category and sub-categorical cluster in more anterior temporal regions. This anteroposterior gradient of information content indicates that different areas along the ventral stream encode complementary dimensions of the semantic space. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. When Meaning Is Not Enough: Distributional and Semantic Cues to Word Categorization in Child Directed Speech.

    Science.gov (United States)

    Feijoo, Sara; Muñoz, Carmen; Amadó, Anna; Serrat, Elisabet

    2017-01-01

    One of the most important tasks in first language development is assigning words to their grammatical category. The Semantic Bootstrapping Hypothesis postulates that, in order to accomplish this task, children are guided by a neat correspondence between semantic and grammatical categories, since nouns typically refer to objects and verbs to actions. It is this correspondence that guides children's initial word categorization. Other approaches, on the other hand, suggest that children might make use of distributional cues and word contexts to accomplish the word categorization task. According to such approaches, the Semantic Bootstrapping assumption offers an important limitation, as it might not be true that all the nouns that children hear refer to specific objects or people. In order to explore that, we carried out two studies based on analyses of children's linguistic input. We analyzed child-directed speech addressed to four children under the age of 2;6, taken from the CHILDES database. The corpora were selected from the Manchester corpus. The corpora from the four selected children contained a total of 10,681 word types and 364,196 word tokens. In our first study, discriminant analyses were performed using semantic cues alone. The results show that many of the nouns found in parents' speech do not relate to specific objects and that semantic information alone might not be sufficient for successful word categorization. Given that there must be an additional source of information which, alongside with semantics, might assist young learners in word categorization, our second study explores the availability of both distributional and semantic cues in child-directed speech. Our results confirm that this combination might yield better results for word categorization. These results are in line with theories that suggest the need for an integration of multiple cues from different sources in language development.

  16. Semantic modeling and structural synthesis of onboard electronics protection means as open information system

    Science.gov (United States)

    Zhevnerchuk, D. V.; Surkova, A. S.; Lomakina, L. S.; Golubev, A. S.

    2018-05-01

    The article describes the component representation approach and semantic models of on-board electronics protection from ionizing radiation of various nature. Semantic models are constructed, the feature of which is the representation of electronic elements, protection modules, sources of impact in the form of blocks with interfaces. The rules of logical inference and algorithms for synthesizing the object properties of the semantic network, imitating the interface between the components of the protection system and the sources of radiation, are developed. The results of the algorithm are considered using the example of radiation-resistant microcircuits 1645RU5U, 1645RT2U and the calculation and experimental method for estimating the durability of on-board electronics.

  17. Dancing with the Web: Students Bring Meaning to the Semantic Web

    Science.gov (United States)

    Brooks, Pauline

    2012-01-01

    This article will discuss the issues concerning the storage, retrieval and use of multimedia technology in dance, and how semantic web technologies can support those requirements. It will identify the key aims and outcomes of four international telematic dance projects, and review the use of reflective practice to engage students in their learning…

  18. The Acquisition of Epistemic Modality: From Semantic Meaning to Pragmatic Interpretation

    Science.gov (United States)

    Ozturk, Ozge; Papafragou, Anna

    2015-01-01

    Three experiments investigated the acquisition of English epistemic modal verbs (e.g., "may", "have to"). Semantically, these verbs encode possibility or necessity with respect to available evidence. Pragmatically, the use of weak epistemic modals often gives rise to scalar conversational inferences (e.g., "The toy may be…

  19. Lexical-Semantic Organization in Bilingually Developing Deaf Children with ASL-Dominant Language Exposure: Evidence from a Repeated Meaning Association Task

    Science.gov (United States)

    Mann, Wolfgang; Sheng, Li; Morgan, Gary

    2016-01-01

    This study compared the lexical-semantic organization skills of bilingually developing deaf children in American Sign Language (ASL) and English with those of a monolingual hearing group. A repeated meaning-association paradigm was used to assess retrieval of semantic relations in deaf 6-10-year-olds exposed to ASL from birth by their deaf…

  20. MEANING OF CO-RESIDENCE IN ELDERLY VISION: A STRATEGY FOR COGNITIVE ANALYSIS WITH USE OF SEMANTICS NETWORKS

    Directory of Open Access Journals (Sweden)

    Claudia Ribeiro Santos Lopes

    2015-06-01

    Full Text Available This paper presents a pilot study for cognitive analysis of the concept of co-residence from the perspective of a group of elderly based on the analysis of semantic networks. The data were collected in research with elderly people in a city in the state of Bahia, using the free evocation of words technique. The term inducer was co-residence. Each individual participant of the research should say up to five words that came to his/her mind. Data analysis was interpretively carried out and related to the use of semantic networks with the theoretical support the social and complex network analysis. The elderly gave to the concept of coresidence the meanings of love, happiness, goodness, union and peace, which leads us to believe the emphasis on co-residence, since it represents an interaction leading to a better living and health conditions.

  1. MEANING OF CO-RESIDENCE IN ELDERLY VISION: A STRATEGY FOR COGNITIVE ANALYSIS WITH USE OF SEMANTICS NETWORKS

    Directory of Open Access Journals (Sweden)

    Claudia Ribeiro Santos Lopes

    2015-04-01

    Full Text Available This paper presents a pilot study for cognitive analysis of the concept of co-residence from the perspective of a group of elderly based on the analysis of semantic networks. The data were collected in research with elderly people in a city in the state of Bahia, using the free evocation of words technique. The term inducer was co-residence. Each individual participant of the research should say up to five words that came to his/her mind. Data analysis was interpretively carried out and related to the use of semantic networks with the theoretical support the social and complex network analysis. The elderly gave to the concept of co-residence the meanings of love, happiness, goodness, union and peace, which leads us to believe the emphasis on co-residence, since it represents an interaction leading to a better living and health conditions.

  2. The interpretation of dream meaning: Resolving ambiguity using Latent Semantic Analysis in a small corpus of text.

    Science.gov (United States)

    Altszyler, Edgar; Ribeiro, Sidarta; Sigman, Mariano; Fernández Slezak, Diego

    2017-11-01

    Computer-based dreams content analysis relies on word frequencies within predefined categories in order to identify different elements in text. As a complementary approach, we explored the capabilities and limitations of word-embedding techniques to identify word usage patterns among dream reports. These tools allow us to quantify words associations in text and to identify the meaning of target words. Word-embeddings have been extensively studied in large datasets, but only a few studies analyze semantic representations in small corpora. To fill this gap, we compared Skip-gram and Latent Semantic Analysis (LSA) capabilities to extract semantic associations from dream reports. LSA showed better performance than Skip-gram in small size corpora in two tests. Furthermore, LSA captured relevant word associations in dream collection, even in cases with low-frequency words or small numbers of dreams. Word associations in dreams reports can thus be quantified by LSA, which opens new avenues for dream interpretation and decoding. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Semantic Meaning in Attitudinal Lexemes in the Domain of Kesenangan (Joy in Indonesian: An Analysis of Meaning Components and Lexical Relation

    Directory of Open Access Journals (Sweden)

    Prima Gusti Yanti

    2017-04-01

    Full Text Available The attitudinal lexeme on the domain of kesenangan in Indonesia language has not shown such clear meaning relationship, for both the common and diagnostic meaning of the lexemes. Those lexemes have such circular definitions, confusing upon their use. This study is conducted using a qualitative research approach employing content analysis technique. The aim of this study is to find out lexical relation and semantic meaning in attitudinal lexeme in the domain of kesenangan (joy in Indonesian language. Data is collected from seven Indonesian dictionaries, two magazines, five newspapers, and six literary works. All data is analyzed using a component analysis in the semantic theory. The research findings show that fourteen (14 lexemes (senang, nikmat, enak, puas, asyik, sukacita, ria, bangga, lega, bahagia, gembira, girang, riang, and ceria of attitudinal lexemes are related with the domain of kesenangan. The result shows that hyponymy and synonymy lexical relations occur in the domain of kesenangan. Synonymy relation consists of near-synonymy and propositional synonymy. In this case, absolute synonymy is not found.

  4. Toxicology ontology perspectives.

    Science.gov (United States)

    Hardy, Barry; Apic, Gordana; Carthew, Philip; Clark, Dominic; Cook, David; Dix, Ian; Escher, Sylvia; Hastings, Janna; Heard, David J; Jeliazkova, Nina; Judson, Philip; Matis-Mitchell, Sherri; Mitic, Dragana; Myatt, Glenn; Shah, Imran; Spjuth, Ola; Tcheremenskaia, Olga; Toldo, Luca; Watson, David; White, Andrew; Yang, Chihae

    2012-01-01

    The field of predictive toxicology requires the development of open, public, computable, standardized toxicology vocabularies and ontologies to support the applications required by in silico, in vitro, and in vivo toxicology methods and related analysis and reporting activities. In this article we review ontology developments based on a set of perspectives showing how ontologies are being used in predictive toxicology initiatives and applications. Perspectives on resources and initiatives reviewed include OpenTox, eTOX, Pistoia Alliance, ToxWiz, Virtual Liver, EU-ADR, BEL, ToxML, and Bioclipse. We also review existing ontology developments in neighboring fields that can contribute to establishing an ontological framework for predictive toxicology. A significant set of resources is already available to provide a foundation for an ontological framework for 21st century mechanistic-based toxicology research. Ontologies such as ToxWiz provide a basis for application to toxicology investigations, whereas other ontologies under development in the biological, chemical, and biomedical communities could be incorporated in an extended future framework. OpenTox has provided a semantic web framework for the implementation of such ontologies into software applications and linked data resources. Bioclipse developers have shown the benefit of interoperability obtained through ontology by being able to link their workbench application with remote OpenTox web services. Although these developments are promising, an increased international coordination of efforts is greatly needed to develop a more unified, standardized, and open toxicology ontology framework.

  5. Testing for a cultural influence on reading for meaning in the developing brain: the neural basis of semantic processing in Chinese children

    Directory of Open Access Journals (Sweden)

    Tai-Li Chou

    2009-11-01

    Full Text Available Functional magnetic resonance imaging (fMRI was used to explore the neural correlates of semantic judgments in a group of 8- to 15-year-old Chinese children. Participants were asked to indicate if pairs of Chinese characters presented visually were related in meaning. The related pairs were arranged in a continuous variable according to association strength. Pairs of characters with weaker semantic association elicited greater activation in the mid ventral region (BA 45 of left inferior frontal gyrus, suggesting increased demands on the process of selecting appropriate semantic features. By contrast, characters with stronger semantic association elicited greater activation in left inferior parietal lobule (BA 39, suggesting stronger integration of highly related features. In addition, there was a developmental increase, similar to previously reported findings in English, in left posterior middle temporal gyrus (BA 21, suggesting that older children have more elaborated semantic representations. There were additional age-related increases in the posterior region of left inferior parietal lobule and in the ventral regions of left inferior frontal gyrus, suggesting that reading acquisition relies more on the mapping from orthography to semantics in Chinese children as compared to previously reported findings in English.

  6. Semantic and Affective Salience: The Role of Meaning and Preference in Attentional Capture and Disengagement

    Science.gov (United States)

    Biggs, Adam T.; Kreager, Ryan D.; Gibson, Bradley S.; Villano, Michael; Crowell, Charles R.

    2012-01-01

    Emotion appears to have a substantial impact on a wide variety of attentional functions. However, stimuli that elicit affective responses also tend to be meaningful. Here we attempted to disentangle the effects of meaning from the effects of affect on attentional capture by irrelevant distractors. Experiment 1 used a previously unfamiliar…

  7. Snapshots for Semantic Maps

    National Research Council Canada - National Science Library

    Nielsen, Curtis W; Ricks, Bob; Goodrich, Michael A; Bruemmer, David; Few, Doug; Walton, Miles

    2004-01-01

    .... Semantic maps are a relatively new approach to information presentation. Semantic maps provide more detail about an environment than typical maps because they are augmented by icons or symbols that provide meaning for places or objects of interest...

  8. The Separability of Morphological Processes from Semantic Meaning and Syntactic Class in Production of Single Words: Evidence from the Hebrew Root Morpheme

    Science.gov (United States)

    Deutsch, Avital

    2016-01-01

    In the present study we investigated to what extent the morphological facilitation effect induced by the derivational root morpheme in Hebrew is independent of semantic meaning and grammatical information of the part of speech involved. Using the picture-word interference paradigm with auditorily presented distractors, Experiment 1 compared the…

  9. Toxicology screen

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003578.htm Toxicology screen To use the sharing features on this page, please enable JavaScript. A toxicology screen refers to various tests that determine the ...

  10. Toxicology elements

    International Nuclear Information System (INIS)

    Viala, A.

    1998-01-01

    This work studies the different aspects of the modern toxicology: toxico-kinetic, biological, medico legal, food, professional, pharmaceuticals, environmental, social and regulatory. It is divided in three parts that consider the principle problems of general toxicology and analytical toxicology. (N.C.)

  11. Green toxicology.

    Science.gov (United States)

    Maertens, Alexandra; Anastas, Nicholas; Spencer, Pamela J; Stephens, Martin; Goldberg, Alan; Hartung, Thomas

    2014-01-01

    Historically, early identification and characterization of adverse effects of industrial chemicals was difficult because conventional toxicological test methods did not meet R&D needs for rapid, relatively inexpensive methods amenable to small amounts of test material. The pharmaceutical industry now front-loads toxicity testing, using in silico, in vitro, and less demanding animal tests at earlier stages of product development to identify and anticipate undesirable toxicological effects and optimize product development. The Green Chemistry movement embraces similar ideas for development of less toxic products, safer processes, and less waste and exposure. Further, the concept of benign design suggests ways to consider possible toxicities before the actual synthesis and to apply some structure/activity rules (SAR) and in silico methods. This requires not only scientific development but also a change in corporate culture in which synthetic chemists work with toxicologists. An emerging discipline called Green Toxicology (Anastas, 2012) provides a framework for integrating the principles of toxicology into the enterprise of designing safer chemicals, thereby minimizing potential toxicity as early in production as possible. Green Toxicology`s novel utility lies in driving innovation by moving safety considerations to the earliest stage in a chemical`s lifecycle, i.e., to molecular design. In principle, this field is no different than other subdisciplines of toxicology that endeavor to focus on a specific area - for example, clinical, environmental or forensic toxicology. We use the same principles and tools to evaluate an existing substance or to design a new one. The unique emphasis is in using 21st century toxicology tools as a preventative strategy to "design out" undesired human health and environmental effects, thereby increasing the likelihood of launching a successful, sustainable product. Starting with the formation of a steering group and a series of workshops

  12. A way toward analyzing high-content bioimage data by means of semantic annotation and visual data mining

    Science.gov (United States)

    Herold, Julia; Abouna, Sylvie; Zhou, Luxian; Pelengaris, Stella; Epstein, David B. A.; Khan, Michael; Nattkemper, Tim W.

    2009-02-01

    In the last years, bioimaging has turned from qualitative measurements towards a high-throughput and highcontent modality, providing multiple variables for each biological sample analyzed. We present a system which combines machine learning based semantic image annotation and visual data mining to analyze such new multivariate bioimage data. Machine learning is employed for automatic semantic annotation of regions of interest. The annotation is the prerequisite for a biological object-oriented exploration of the feature space derived from the image variables. With the aid of visual data mining, the obtained data can be explored simultaneously in the image as well as in the feature domain. Especially when little is known of the underlying data, for example in the case of exploring the effects of a drug treatment, visual data mining can greatly aid the process of data evaluation. We demonstrate how our system is used for image evaluation to obtain information relevant to diabetes study and screening of new anti-diabetes treatments. Cells of the Islet of Langerhans and whole pancreas in pancreas tissue samples are annotated and object specific molecular features are extracted from aligned multichannel fluorescence images. These are interactively evaluated for cell type classification in order to determine the cell number and mass. Only few parameters need to be specified which makes it usable also for non computer experts and allows for high-throughput analysis.

  13. Forensic toxicology.

    Science.gov (United States)

    Davis, Gregory G

    2012-01-01

    Toxicologic analysis is an integral part of death investigation, and the use or abuse of an unsuspected substance belongs in the differential diagnosis of patients who have a sudden, unexpected change in their condition. History and physical findings may alter suspicion that intoxication played a role in a patient's decline or death, but suspicions cannot be confirmed and is performed, analysis unless toxicologic no toxicologic analysis is possible unless someone collects the proper specimens necessary for analysis. In a hospital autopsy the only specimens that can rightfully be collected are those within the restrictions stated in the autopsy permit. Autopsies performed by the medical examiner do not have these restrictions. Sometimes the importance of toxicologic testing in a case is not evident until days or weeks after the change in the patient's status, thus retaining the appropriate specimens until investigation of that case has ended is important. Proper interpretation of toxicologic findings requires integrating the clinical setting and findings with the toxicologic results in a way that makes medical sense. If called upon to testify concerning findings, answer the questions truthfully, politely, and in a way that is understandable to someone who has no special training in toxicology.

  14. Jigsaw Semantics

    Directory of Open Access Journals (Sweden)

    Paul J. E. Dekker

    2010-12-01

    Full Text Available In the last decade the enterprise of formal semantics has been under attack from several philosophical and linguistic perspectives, and it has certainly suffered from its own scattered state, which hosts quite a variety of paradigms which may seem to be incompatible. It will not do to try and answer the arguments of the critics, because the arguments are often well-taken. The negative conclusions, however, I believe are not. The only adequate reply seems to be a constructive one, which puts several pieces of formal semantics, in particular dynamic semantics, together again. In this paper I will try and sketch an overview of tasks, techniques, and results, which serves to at least suggest that it is possible to develop a coherent overall picture of undeniably important and structural phenomena in the interpretation of natural language. The idea is that the concept of meanings as truth conditions after all provides an excellent start for an integrated study of the meaning and use of natural language, and that an extended notion of goal directed pragmatics naturally complements this picture. None of the results reported here are really new, but we think it is important to re-collect them.ReferencesAsher, Nicholas & Lascarides, Alex. 1998. ‘Questions in Dialogue’. Linguistics and Philosophy 23: 237–309.http://dx.doi.org/10.1023/A:1005364332007Borg, Emma. 2007. ‘Minimalism versus contextualism in semantics’. In Gerhard Preyer & Georg Peter (eds. ‘Context-Sensitivity and Semantic Minimalism’, pp. 339–359. Oxford: Oxford University Press.Cappelen, Herman & Lepore, Ernest. 1997. ‘On an Alleged Connection between Indirect Quotation and Semantic Theory’. Mind and Language 12: pp. 278–296.Cappelen, Herman & Lepore, Ernie. 2005. Insensitive Semantics. Oxford: Blackwell.http://dx.doi.org/10.1002/9780470755792Dekker, Paul. 2002. ‘Meaning and Use of Indefinite Expressions’. Journal of Logic, Language and Information 11: pp. 141–194

  15. Temporal Representation in Semantic Graphs

    Energy Technology Data Exchange (ETDEWEB)

    Levandoski, J J; Abdulla, G M

    2007-08-07

    A wide range of knowledge discovery and analysis applications, ranging from business to biological, make use of semantic graphs when modeling relationships and concepts. Most of the semantic graphs used in these applications are assumed to be static pieces of information, meaning temporal evolution of concepts and relationships are not taken into account. Guided by the need for more advanced semantic graph queries involving temporal concepts, this paper surveys the existing work involving temporal representations in semantic graphs.

  16. Semantic Multimedia

    NARCIS (Netherlands)

    S. Staab; A. Scherp; R. Arndt; R. Troncy (Raphael); M. Grzegorzek; C. Saathoff; S. Schenk; L. Hardman (Lynda)

    2008-01-01

    htmlabstractMultimedia constitutes an interesting field of application for Semantic Web and Semantic Web reasoning, as the access and management of multimedia content and context depends strongly on the semantic descriptions of both. At the same time, multimedia resources constitute complex objects,

  17. Generative Semantics.

    Science.gov (United States)

    King, Margaret

    The first section of this paper deals with the attempts within the framework of transformational grammar to make semantics a systematic part of linguistic description, and outlines the characteristics of the generative semantics position. The second section takes a critical look at generative semantics in its later manifestations, and makes a case…

  18. Behavior Modification Through Covert Semantic Desensitization

    Science.gov (United States)

    Hekmat, Hamid; Vanian, Daniel

    1971-01-01

    Results support the hypothesized relationship between meaning and phobia. Semantic desensitization techniques based on counter conditioning of meaning were significantly effective in altering the semantic value of the word from unpleasantness to neutrality. (Author)

  19. Semantic change and grammaticalization : The development of modal and postmodal meanings in Mainland Scandinavian ma, matte and maste

    NARCIS (Netherlands)

    Beijering, K.

    2011-01-01

    This paper presents a comparative synchronic corpus investigation of Mainland Scandinavian ma, matte and maste 'must, may'. These modals developed a wide range of different meanings and uses within the realm of necessity, possibility and beyond, i.e., ability, capacity, need, desirability,

  20. The Two-Level Theory of verb meaning: An approach to integrating the semantics of action with the mirror neuron system.

    Science.gov (United States)

    Kemmerer, David; Gonzalez-Castillo, Javier

    2010-01-01

    Verbs have two separate levels of meaning. One level reflects the uniqueness of every verb and is called the "root". The other level consists of a more austere representation that is shared by all the verbs in a given class and is called the "event structure template". We explore the following hypotheses about how, with specific reference to the motor features of action verbs, these two distinct levels of semantic representation might correspond to two distinct levels of the mirror neuron system. Hypothesis 1: Root-level motor features of verb meaning are partially subserved by somatotopically mapped mirror neurons in the left primary motor and/or premotor cortices. Hypothesis 2: Template-level motor features of verb meaning are partially subserved by representationally more schematic mirror neurons in Brodmann area 44 of the left inferior frontal gyrus. Evidence has been accumulating in support of the general neuroanatomical claims made by these two hypotheses-namely, that each level of verb meaning is associated with the designated cortical areas. However, as yet no studies have satisfied all the criteria necessary to support the more specific neurobiological claims made by the two hypotheses-namely, that each level of verb meaning is associated with mirror neurons in the pertinent brain regions. This would require demonstrating that within those regions the same neuronal populations are engaged during (a) the linguistic processing of particular motor features of verb meaning, (b) the execution of actions with the corresponding motor features, and (c) the observation of actions with the corresponding motor features. 2008 Elsevier Inc. All rights reserved.

  1. A Machine Learning Based Analytical Framework for Semantic Annotation Requirements

    OpenAIRE

    Hamed Hassanzadeh; MohammadReza Keyvanpour

    2011-01-01

    The Semantic Web is an extension of the current web in which information is given well-defined meaning. The perspective of Semantic Web is to promote the quality and intelligence of the current web by changing its contents into machine understandable form. Therefore, semantic level information is one of the cornerstones of the Semantic Web. The process of adding semantic metadata to web resources is called Semantic Annotation. There are many obstacles against the Semantic Annotation, such as ...

  2. Semantic Songket Image Search with Cultural Computing of Symbolic Meaning Extraction and Analytical Aggregation of Color and Shape Features

    Directory of Open Access Journals (Sweden)

    Desi Amirullah

    2015-06-01

    Full Text Available The term "Songket" comes from the Malay word "Sungkit", which means "to hook" or "to gouge". Every motifs names and variations was derived from plants and animals as source of inspiration to create many patterns of songket. Each of songket patterns have a philosophy in form of rhyme that refers to the nature of the sources of songket patterns and that philosophy reflects to the beliefs and values of Malay culture. In this research, we propose a system to facilitate an understanding of songket and the philosophy as a way to conserve Songket culture. We propose a system which is able to collect information in image songket motif variations based on feature extraction methods. On each image songket motif variations, we extracted philosophy of rhyme into impressions, and extracting color features of songket images using a histogram 3D-Color Vector quantization (3D-CVQ, shape feature extraction songket image using HU Moment invariants. Then, we created an image search based on impressions, and impressions search based on image. We use techniques of search based on color, shape and aggregation (combination of colors and shapes. The experiment using impression as query : 1 Result based on color, the average value of true 7.3, total score 41.9, 2 Result based on shape, the average value of true 3, total score 16.4, 3 Result based on aggregation, the average value of true 3, total score 17.4. While based using Image Query : 1 Result based on color, the average precision 95%, 2 Result based on shape, average precision 43.3%, 3 Based aggregation, the average precision 73.3%. From our experiments, it can be concluded that the best search system using query impression and query image is based on the color. Keyword : Image Search, Philosophy, impression, Songket, cultural computing, Feature Extraction, Analytical aggregation.

  3. Semantic metrics

    OpenAIRE

    Hu, Bo; Kalfoglou, Yannis; Dupplaw, David; Alani, Harith; Lewis, Paul; Shadbolt, Nigel

    2006-01-01

    In the context of the Semantic Web, many ontology-related operations, e.g. ontology ranking, segmentation, alignment, articulation, reuse, evaluation, can be boiled down to one fundamental operation: computing the similarity and/or dissimilarity among ontological entities, and in some cases among ontologies themselves. In this paper, we review standard metrics for computing distance measures and we propose a series of semantic metrics. We give a formal account of semantic metrics drawn from a...

  4. TOXNET: Toxicology Data Network

    Science.gov (United States)

    ... to TOXNET Your resource for searching databases on toxicology, hazardous chemicals, environmental health, and toxic releases SEARCH ... over 3,000 chemicals (1991-1998) Environmental Health & Toxicology Resources on environmental health and toxicology Visit Site ...

  5. Relaxation as a Factor in Semantic Desensitization

    Science.gov (United States)

    Bechtel, James E.; McNamara, J. Regis

    1975-01-01

    Relaxation and semantic desensitization were used to alleviate the fear of phobic females. Results showed that semantic desensitization, alone or in combination with relaxation, failed to modify the evaluative meanings evoked by the feared object. (SE)

  6. Montague semantics

    NARCIS (Netherlands)

    Janssen, T.M.V.

    2012-01-01

    Montague semantics is a theory of natural language semantics and of its relation with syntax. It was originally developed by the logician Richard Montague (1930-1971) and subsequently modified and extended by linguists, philosophers, and logicians. The most important features of the theory are its

  7. Space Toxicology

    Science.gov (United States)

    James, John T.

    2011-01-01

    Safe breathing air for space faring crews is essential whether they are inside an Extravehicular Mobility Suit (EMU), a small capsule such as Soyuz, or the expansive International Space Station (ISS). Sources of air pollution can include entry of propellants, excess offgassing from polymeric materials, leakage of systems compounds, escape of payload compounds, over-use of utility compounds, microbial metabolism, and human metabolism. The toxicological risk posed by a compound is comprised of the probability of escaping to cause air pollution and the magnitude of adverse effects on human health if escape occurs. The risk from highly toxic compounds is controlled by requiring multiple levels of containment to greatly reduce the probability of escape; whereas compounds that are virtually non-toxic may require little or no containment. The potential for toxicity is determined by the inherent toxicity of the compound and the amount that could potentially escape into the breathing air.

  8. Animal toxicology

    Energy Technology Data Exchange (ETDEWEB)

    Amdur, M.

    1996-12-31

    The chapter evaluates results of toxicological studies on experimental animals to investigate health effects of air pollutants and examines the animal data have predicted the response to human subject. Data are presented on the comparative toxicity of sulfur dioxide and sulfuric acid. The animal data obtained by measurement of airway resistance in guinea pigs and of bronchial clearance of particles in donkeys predicted clearly that sulfuric acid was more irritant than sulfur dioxide. Data obtained on human subjects confirmed this prediction. These acute studies also correctly predicted the comparative toxicity of the two compounds in two year studies of monkeys. Such chronic studies are not possible in human subjects but it is a reasonable to assume that sulfuric acid would be more toxic than sulfur dioxide. Current findings in epidemiological studies certainly support this assumption.

  9. Computing meaning v.4

    CERN Document Server

    Bunt, Harry; Pulman, Stephen

    2013-01-01

    This book is a collection of papers by leading researchers in computational semantics. It presents a state-of-the-art overview of recent and current research in computational semantics, including descriptions of new methods for constructing and improving resources for semantic computation, such as WordNet, VerbNet, and semantically annotated corpora. It also presents new statistical methods in semantic computation, such as the application of distributional semantics in the compositional calculation of sentence meanings. Computing the meaning of sentences, texts, and spoken or texted dialogue i

  10. Forensic Toxicology: An Introduction.

    Science.gov (United States)

    Smith, Michael P; Bluth, Martin H

    2016-12-01

    This article presents an overview of forensic toxicology. The authors describe the three components that make up forensic toxicology: workplace drug testing, postmortem toxicology, and human performance toxicology. Also discussed are the specimens that are tested, the methods used, and how the results are interpreted in this particular discipline. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Semantic Desktop

    Science.gov (United States)

    Sauermann, Leo; Kiesel, Malte; Schumacher, Kinga; Bernardi, Ansgar

    In diesem Beitrag wird gezeigt, wie der Arbeitsplatz der Zukunft aussehen könnte und wo das Semantic Web neue Möglichkeiten eröffnet. Dazu werden Ansätze aus dem Bereich Semantic Web, Knowledge Representation, Desktop-Anwendungen und Visualisierung vorgestellt, die es uns ermöglichen, die bestehenden Daten eines Benutzers neu zu interpretieren und zu verwenden. Dabei bringt die Kombination von Semantic Web und Desktop Computern besondere Vorteile - ein Paradigma, das unter dem Titel Semantic Desktop bekannt ist. Die beschriebenen Möglichkeiten der Applikationsintegration sind aber nicht auf den Desktop beschränkt, sondern können genauso in Web-Anwendungen Verwendung finden.

  12. Semantic Keys and Reading

    Directory of Open Access Journals (Sweden)

    Zev bar-Lev

    2016-12-01

    Full Text Available Semantic Keys are elements (word-parts of written language that give an iconic, general representation of the whole word’s meaning. In written Sino-Japanese the “radical” or semantic components play this role. For example, the character meaning ‘woman, female’ is the Semantic Key of the character for Ma ‘Mama’ (alongside the phonetic component Ma, which means ‘horse’ as a separate character. The theory of semantic Keys in both graphic and phonemic aspects is called qTheory or nanosemantics. The most innovative aspect of the present article is the hypothesis that, in languages using alphabetic writing systems, the role of Semantic Key is played by consonants, more specifically the first consonant. Thus, L meaning ‘LIFT’ is the Semantic Key of English Lift, Ladle, Lofty, aLps, eLevator, oLympus; Spanish Leva, Lecantarse, aLto, Lengua; Arabic aLLah, and Hebrew① ªeL-ºaL ‘upto-above’ (the Israeli airline, Polish Lot ‘flight’ (the Polish airline; Hebrew ªeL, ªeLohim ‘God’, and haLLeluyah ‘praise-ye God’ (using Parallels, ‘Lift up God’. Evidence for the universality of the theory is shown by many examples drawn from various languages, including Indo-European Semitic, Chinese and Japanese. The theory reveals hundreds of relationships within and between languages, related and unrelated, that have been “Hiding in Plain Sight”, to mention just one example: the Parallel between Spanish Pan ‘bread’ and Mandarin Fan ‘rice’.

  13. Complications of Translating the Meanings of the Holy Qur'an at Word Level in the English Language in Relation to Frame Semantic Theory

    Science.gov (United States)

    Balla, Asjad Ahmed Saeed; Siddiek, Ahmed Gumaa

    2017-01-01

    The present study is an attempt to investigate the problems resulting from the lexical choice in the translation of the Holy Qur'an to emphasize the importance of the theory of "Frame Semantics" in the translation process. It has been conducted with the aim of measuring the difference in concept between the two languages Arabic and…

  14. Meaning

    Science.gov (United States)

    Harteveld, Casper

    The second world to be considered concerns Meaning. In contrast to Reality and Play, this world relates to the people, disciplines, and domains that are focused on creating a certain value. For example, if this value is about providing students knowledge about physics, it involves teachers, the learning sciences, and the domains education and physics. This level goes into the aspects and criteria that designers need to take into account from this perspective. The first aspect seems obvious when we talk of “games with a serious purpose.” They have a purpose and this needs to be elaborated on, for example in terms of what “learning objectives” it attempts to achieve. The subsequent aspect is not about what is being pursued but how. To attain a value, designers have to think about a strategy that they employ. In my case this concerned looking at the learning paradigms that have come into existence in the past century and see what they have to tell us about learning. This way, their principles can be translated into a game environment. This translation involves making the strategy concrete. Or, in other words, operationalizing the plan. This is the third aspect. In this level, I will further specifically explain how I derived requirements from each of the learning paradigms, like reflection and exploration, and how they can possibly be related to games. The fourth and final aspect is the context in which the game is going to be used. It matters who uses the game and when, where, and how the game is going to be used. When designers have looked at these aspects, they have developed a “value proposal” and the worth of it may be judged by criteria, like motivation, relevance, and transfer. But before I get to this, I first go into how we human beings are meaning creators and what role assumptions, knowledge, and ambiguity have in this. I will illustrate this with some silly jokes about doctors and Mickey Mouse, and with an illusion.

  15. Evolution of semantic systems

    CERN Document Server

    Küppers, Bernd-Olaf; Artmann, Stefan

    2013-01-01

    Complex systems in nature and society make use of information for the development of their internal organization and the control of their functional mechanisms. Alongside technical aspects of storing, transmitting and processing information, the various semantic aspects of information, such as meaning, sense, reference and function, play a decisive part in the analysis of such systems.With the aim of fostering a better understanding of semantic systems from an evolutionary and multidisciplinary perspective, this volume collects contributions by philosophers and natural scientists, linguists, i

  16. Cornerstones of Toxicology.

    Science.gov (United States)

    Hayes, A Wallace; Dixon, Darlene

    2017-01-01

    The 35th Annual Society of Toxicologic Pathology Symposium, held in June 2016 in San Diego, California, focused on "The Basis and Relevance of Variation in Toxicologic Responses." In order to review the basic tenants of toxicology, a "broad brush" interactive talk that gave an overview of the Cornerstones of Toxicology was presented. The presentation focused on the historical milestones and perspectives of toxicology and through many scientific graphs, data, and real-life examples covered the three basic principles of toxicology that can be summarized, as dose matters (as does timing), people differ, and things change (related to metabolism and biotransformation).

  17. Polycyclic aromatic hydrocarbon-contaminated soils: bioaugmentation of autochthonous bacteria and toxicological assessment of the bioremediation process by means of Vicia faba L.

    Science.gov (United States)

    Ruffini Castiglione, Monica; Giorgetti, Lucia; Becarelli, Simone; Siracusa, Giovanna; Lorenzi, Roberto; Di Gregorio, Simona

    2016-04-01

    Two bacterial strains, Achromobacter sp. (ACH01) and Sphingomonas sp. (SPH01), were isolated from a heavily polycyclic aromatic hydrocarbon (PAH)-contaminated soil (5431.3 ± 102.3 ppm) for their capacity to use a mixture of anthracene, pyrene, phenanthrene and fluorene as sole carbon sources for growth and for the capacity to produce biosurfactants. The two strains were exploited for bioaugmentation in a biopile pilot plant to increase the bioavailability and the degradation of the residual PAH contamination (99.5 ± 7.1 ppm) reached after 9 months of treatment. The denaturing gel gradient electrophoresis (DGGE) profile of the microbial ecology of the soil during the experimentation showed that the bioaugmentation approach was successful in terms of permanence of the two strains in the soil in treatment. The bioaugmentation of the two bacterial isolates positively correlated with the PAH depletion that reached 7.9 ± 2 ppm value in 2 months of treatment. The PAH depletion was assessed by the loss of the phyto-genotoxicity of soil elutriates on the model plant Vicia faba L., toxicological assessment adopted also to determine the minimum length of the decontamination process for obtaining both the depletion of the PAH contamination and the detoxification of the soil at the end of the process. The intermediate phases of the bioremediation process were the most significant in terms of toxicity, inducing genotoxic effects and selective DNA fragmentation in the stem cell niche of the root tip. The selective DNA fragmentation can be related to the selective induction of cell death of mutant stem cells that can compromise offsprings.

  18. National Toxicology Program

    Science.gov (United States)

    ... NTP? NTP develops and applies tools of modern toxicology and molecular biology to identify substances in the ... depend on for decisions that matter. The National Toxicology Program provides the scientific basis for programs, activities, ...

  19. Toxicology Education Foundation

    Science.gov (United States)

    ... bodies and our world. Welcome to the Toxicology Education Foundation! Our mission is to enhance public understanding ... In with us, follow our Tweets, choose Toxicology Education Foundation as your preferred charity through Smile.Amazon. ...

  20. Environmental Toxicology Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Fully-equipped facilities for environmental toxicology researchThe Environmental Toxicology Research Facility (ETRF) located in Vicksburg, MS provides over 8,200 ft...

  1. Handbook of systems toxicology

    National Research Council Canada - National Science Library

    Casciano, Daniel A; Sahu, Saura C

    2011-01-01

    "In the first handbook to comprehensively cover the emerging area of systems toxicology, the Handbook of Systems Toxicology provides an authoritative compilation of up-to-date developments presented...

  2. Green Toxicology – Application of predictive toxicology

    DEFF Research Database (Denmark)

    Vinggaard, Anne Marie; Wedebye, Eva Bay; Taxvig, Camilla

    2014-01-01

    safer chemicals and to identify problematic compounds already in use such as industrial compounds, drugs, pesticides and cosmetics, is required. Green toxicology is the application of predictive toxicology to the production of chemicals with the specific intent of improving their design for hazard...

  3. Representations for Semantic Learning Webs: Semantic Web Technology in Learning Support

    Science.gov (United States)

    Dzbor, M.; Stutt, A.; Motta, E.; Collins, T.

    2007-01-01

    Recent work on applying semantic technologies to learning has concentrated on providing novel means of accessing and making use of learning objects. However, this is unnecessarily limiting: semantic technologies will make it possible to develop a range of educational Semantic Web services, such as interpretation, structure-visualization, support…

  4. Pascal Semantics by a Combination of Denotational Semantics and High-level Petri Nets

    DEFF Research Database (Denmark)

    Jensen, Kurt; Schmidt, Erik Meineche

    1986-01-01

    This paper describes the formal semantics of a subset of PASCAL, by means of a semantic model based on a combination of denotational semantics and high-level Petri nets. It is our intention that the paper can be used as part of the written material for an introductory course in computer science....

  5. Generative Semantics

    Science.gov (United States)

    Bagha, Karim Nazari

    2011-01-01

    Generative semantics is (or perhaps was) a research program within linguistics, initiated by the work of George Lakoff, John R. Ross, Paul Postal and later McCawley. The approach developed out of transformational generative grammar in the mid 1960s, but stood largely in opposition to work by Noam Chomsky and his students. The nature and genesis of…

  6. Inferentializing Semantics

    Czech Academy of Sciences Publication Activity Database

    Peregrin, Jaroslav

    2010-01-01

    Roč. 39, č. 3 (2010), s. 255-274 ISSN 0022-3611 R&D Projects: GA ČR(CZ) GA401/07/0904 Institutional research plan: CEZ:AV0Z90090514 Keywords : inference * proof theory * model theory * inferentialism * semantics Subject RIV: AA - Philosophy ; Religion

  7. Semantic Blogging : Spreading the Semantic Web Meme

    OpenAIRE

    Cayzer, Steve

    2004-01-01

    This paper is about semantic blogging, an application of the semantic web to blogging. The semantic web promises to make the web more useful by endowing metadata with machine processable semantics. Blogging is a lightweight web publishing paradigm which provides a very low barrier to entry, useful syndication and aggregation behaviour, a simple to understand structure and decentralized construction of a rich information network. Semantic blogging builds upon the success and clear network valu...

  8. Trust estimation of the semantic web using semantic web clustering

    Science.gov (United States)

    Shirgahi, Hossein; Mohsenzadeh, Mehran; Haj Seyyed Javadi, Hamid

    2017-05-01

    Development of semantic web and social network is undeniable in the Internet world these days. Widespread nature of semantic web has been very challenging to assess the trust in this field. In recent years, extensive researches have been done to estimate the trust of semantic web. Since trust of semantic web is a multidimensional problem, in this paper, we used parameters of social network authority, the value of pages links authority and semantic authority to assess the trust. Due to the large space of semantic network, we considered the problem scope to the clusters of semantic subnetworks and obtained the trust of each cluster elements as local and calculated the trust of outside resources according to their local trusts and trust of clusters to each other. According to the experimental result, the proposed method shows more than 79% Fscore that is about 11.9% in average more than Eigen, Tidal and centralised trust methods. Mean of error in this proposed method is 12.936, that is 9.75% in average less than Eigen and Tidal trust methods.

  9. Are Some Semantic Changes Predictable?

    DEFF Research Database (Denmark)

    Schousboe, Steen

    2010-01-01

      Historical linguistics is traditionally concerned with phonology and syntax. With the exception of grammaticalization - the development of auxiliary verbs, the syntactic rather than localistic use of prepositions, etc. - semantic change has usually not been described as a result of regular...... developments, but only as specific meaning changes in individual words. This paper will suggest some regularities in semantic change, regularities which, like sound laws, have predictive power and can be tested against recorded languages....

  10. Semantics, contrastive linguistics and parallel corpora

    Directory of Open Access Journals (Sweden)

    Violetta Koseska

    2014-09-01

    Full Text Available Semantics, contrastive linguistics and parallel corpora In view of the ambiguity of the term “semantics”, the author shows the differences between the traditional lexical semantics and the contemporary semantics in the light of various semantic schools. She examines semantics differently in connection with contrastive studies where the description must necessary go from the meaning towards the linguistic form, whereas in traditional contrastive studies the description proceeded from the form towards the meaning. This requirement regarding theoretical contrastive studies necessitates construction of a semantic interlanguage, rather than only singling out universal semantic categories expressed with various language means. Such studies can be strongly supported by parallel corpora. However, in order to make them useful for linguists in manual and computer translations, as well as in the development of dictionaries, including online ones, we need not only formal, often automatic, annotation of texts, but also semantic annotation - which is unfortunately manual. In the article we focus on semantic annotation concerning time, aspect and quantification of names and predicates in the whole semantic structure of the sentence on the example of the “Polish-Bulgarian-Russian parallel corpus”.

  11. A Semantic Analysis Method for Scientific and Engineering Code

    Science.gov (United States)

    Stewart, Mark E. M.

    1998-01-01

    This paper develops a procedure to statically analyze aspects of the meaning or semantics of scientific and engineering code. The analysis involves adding semantic declarations to a user's code and parsing this semantic knowledge with the original code using multiple expert parsers. These semantic parsers are designed to recognize formulae in different disciplines including physical and mathematical formulae and geometrical position in a numerical scheme. In practice, a user would submit code with semantic declarations of primitive variables to the analysis procedure, and its semantic parsers would automatically recognize and document some static, semantic concepts and locate some program semantic errors. A prototype implementation of this analysis procedure is demonstrated. Further, the relationship between the fundamental algebraic manipulations of equations and the parsing of expressions is explained. This ability to locate some semantic errors and document semantic concepts in scientific and engineering code should reduce the time, risk, and effort of developing and using these codes.

  12. Semantically Enhanced Recommender Systems

    Science.gov (United States)

    Ruiz-Montiel, Manuela; Aldana-Montes, José F.

    Recommender Systems have become a significant area in the context of web personalization, given the large amount of available data. Ontologies can be widely taken advantage of in recommender systems, since they provide a means of classifying and discovering of new information about the items to recommend, about user profiles and even about their context. We have developed a semantically enhanced recommender system based on this kind of ontologies. In this paper we present a description of the proposed system.

  13. Recall from Semantic and Episodic Memory.

    Science.gov (United States)

    Gillund, Gary; Perlmutter, Marion

    Although research in episodic recall memory, comparing younger and older adults, favors the younger adults, findings in semantic memory research are less consistent. To examine age differences in semantic and episodic memory recall, 72 young adults (mean age, 20.8) and 72 older adults (mean age 71) completed three memory tests under varied…

  14. Nuclear toxicology at CEA

    International Nuclear Information System (INIS)

    Giustranti, C.

    2001-01-01

    CEA (French commission of atomic energy) has launched a new program dedicated to the study of the transfer of heavy metals and some radionuclides from environment to living beings. The substances that will be studied, are those that are involved in research, medical activities, and in nuclear industry. It means iodine, technetium, trans-uranides (uranium and plutonium), fission products (iodine, cesium), carbon, cobalt, boron and beryllium. This program is composed of 2 axis: the first one concerns the bio-geo-chemical cycles that are involved in transfer and the second axis deals with the detoxication processes that appear in animal and man cells. This program will rely on the strong competencies of CEA in chemistry, radiochemistry, biology, physiology and toxicology. (A.C.)

  15. Semantics, Conceptual Role

    OpenAIRE

    Block, Ned

    1997-01-01

    According to Conceptual Role Semantics ("CRS"), the meaning of a representation is the role of that representation in the cognitive life of the agent, e.g. in perception, thought and decision-making. It is an extension of the well known "use" theory of meaning, according to which the meaning of a word is its use in communication and more generally, in social interaction. CRS supplements external use by including the role of a symbol inside a computer or a brain. The uses appealed to are not j...

  16. A Denotational Semantics for Logic Programming

    DEFF Research Database (Denmark)

    Frandsen, Gudmund Skovbjerg

    A fully abstract denotational semantics for logic programming has not been constructed yet. In this paper we present a denotational semantics that is almost fully abstract. We take the meaning of a logic program to be an element in a Plotkin power domain of substitutions. In this way our result...... shows that standard domain constructions suffice, when giving a semantics for logic programming. Using the well-known fixpoint semantics of logic programming we have to consider two different fixpoints in order to obtain information about both successful and failed computations. In contrast, our...... semantics is uniform in that the (single) meaning of a logic program contains information about both successful, failed and infinite computations. Finally, based on the full abstractness result, we argue that the detail level of substitutions is needed in any denotational semantics for logic programming....

  17. Method for the control of (rat) liver functions by means of 14C-acetate for the toxicological analysis of foreign substances

    International Nuclear Information System (INIS)

    Seidler, H.; Koslowski, C.; Haertig, M.

    1977-01-01

    A test procedure is presented which permits to obtain, by means of a single carbon-14-labelled compound as structural element in a series of essential substances, a survey of important fields of liver function. Special attention was paid to cholesterol. Methodical studies resulted in an optimization of the application under in vivo and in vitro conditions, and of the isolation of carbon-14-labelled cholesterol, ester cholesterol and glucose as well as of carbon-14-labelled phospholipids, triglycerides, bile acids, proteins and nucleic acids as groups. A comparison of the experimental techniques demonstrated the advantages of in vivo application. The method and its validity are illustrated by an example (DDT). Its use in studies on various active principles will be dealt with in future communications. (author)

  18. Reproductive and developmental toxicology

    National Research Council Canada - National Science Library

    Gupta, Ramesh C

    2011-01-01

    .... Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science...

  19. A primer on systematic reviews in toxicology.

    Science.gov (United States)

    Hoffmann, Sebastian; de Vries, Rob B M; Stephens, Martin L; Beck, Nancy B; Dirven, Hubert A A M; Fowle, John R; Goodman, Julie E; Hartung, Thomas; Kimber, Ian; Lalu, Manoj M; Thayer, Kristina; Whaley, Paul; Wikoff, Daniele; Tsaioun, Katya

    2017-07-01

    Systematic reviews, pioneered in the clinical field, provide a transparent, methodologically rigorous and reproducible means of summarizing the available evidence on a precisely framed research question. Having matured to a well-established approach in many research fields, systematic reviews are receiving increasing attention as a potential tool for answering toxicological questions. In the larger framework of evidence-based toxicology, the advantages and obstacles of, as well as the approaches for, adapting and adopting systematic reviews to toxicology are still being explored. To provide the toxicology community with a starting point for conducting or understanding systematic reviews, we herein summarized available guidance documents from various fields of application. We have elaborated on the systematic review process by breaking it down into ten steps, starting with planning the project, framing the question, and writing and publishing the protocol, and concluding with interpretation and reporting. In addition, we have identified the specific methodological challenges of toxicological questions and have summarized how these can be addressed. Ultimately, this primer is intended to stimulate scientific discussions of the identified issues to fuel the development of toxicology-specific methodology and to encourage the application of systematic review methodology to toxicological issues.

  20. Semantic interpretation of search engine resultant

    Science.gov (United States)

    Nasution, M. K. M.

    2018-01-01

    In semantic, logical language can be interpreted in various forms, but the certainty of meaning is included in the uncertainty, which directly always influences the role of technology. One results of this uncertainty applies to search engines as user interfaces with information spaces such as the Web. Therefore, the behaviour of search engine results should be interpreted with certainty through semantic formulation as interpretation. Behaviour formulation shows there are various interpretations that can be done semantically either temporary, inclusion, or repeat.

  1. SEMANTIC DERIVATION OF BORROWINGS

    Directory of Open Access Journals (Sweden)

    Shigapova, F.F.

    2017-09-01

    Full Text Available The author carried out the contrastive analysis of the word спикер borrowed into Russian from English and the English word speaker. The findings of the analysis include confirm (1 different derivational abilities and functions of the borrowed word and the native word; (2 distinctive features in the definitions, i.e. semantic structures, registered in monolingual non-abridged dictionaries; (3 heterogeneous parameters of frequencies recorded in the National Corpus of the Russian language and the British National Corpus; (4 absence of bilingual equivalent collocations with words спикер and speaker. The collocations with words studied revealed new lexical and connotative senses in the meaning of the word. Relevance of the study conducted is justified by the new facts revealed about the semantic adaptation of the borrowed word in the system of the Russian language and its paradigmatic and syntagmatic connections in the system of the recipient language.

  2. Fossil fuel toxicology

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    A program is described for the investigation of the toxicology of coal-derived effluents that will utilize a battery of cellular and mammalian test systems and end points to evaluate the toxicological effects of acute, sub-acute, and long-term, low-level exposure to gaseous and particulate effluents from combustion of coal, with special emphasis on fluidized bed combustion

  3. COTARD SYNDROME IN SEMANTIC DEMENTIA

    Science.gov (United States)

    Mendez, Mario F.; Ramírez-Bermúdez, Jesús

    2011-01-01

    Background Semantic dementia is a neurodegenerative disorder characterized by the loss of meaning of words or concepts. semantic dementia can offer potential insights into the mechanisms of content-specific delusions. Objective The authors present a rare case of semantic dementia with Cotard syndrome, a delusion characterized by nihilism or self-negation. Method The semantic deficits and other features of semantic dementia were evaluated in relation to the patient's Cotard syndrome. Results Mrs. A developed the delusional belief that she was wasting and dying. This occurred after she lost knowledge for her somatic discomforts and sensations and for the organs that were the source of these sensations. Her nihilistic beliefs appeared to emerge from her misunderstanding of her somatic sensations. Conclusion This unique patient suggests that a mechanism for Cotard syndrome is difficulty interpreting the nature and source of internal pains and sensations. We propose that loss of semantic knowledge about one's own body may lead to the delusion of nihilism or death. PMID:22054629

  4. SEMANTIC WEB MINING: ISSUES AND CHALLENGES

    OpenAIRE

    Karan Singh*, Anil kumar, Arun Kumar Yadav

    2016-01-01

    The combination of the two fast evolving scientific research areas “Semantic Web” and “Web Mining” are well-known as “Semantic Web Mining” in computer science. These two areas cover way for the mining of related and meaningful information from the web, by this means giving growth to the term “Semantic Web Mining”. The “Semantic Web” makes mining easy and “Web Mining” can construct new structure of Web. Web Mining applies Data Mining technique on web content, Structure and Usage. This paper gi...

  5. Preserved musical semantic memory in semantic dementia.

    Science.gov (United States)

    Weinstein, Jessica; Koenig, Phyllis; Gunawardena, Delani; McMillan, Corey; Bonner, Michael; Grossman, Murray

    2011-02-01

    To understand the scope of semantic impairment in semantic dementia. Case study. Academic medical center. A man with semantic dementia, as demonstrated by clinical, neuropsychological, and imaging studies. Music performance and magnetic resonance imaging results. Despite profoundly impaired semantic memory for words and objects due to left temporal lobe atrophy, this semiprofessional musician was creative and expressive in demonstrating preserved musical knowledge. Long-term representations of words and objects in semantic memory may be dissociated from meaningful knowledge in other domains, such as music.

  6. Inquisitive semantics and pragmatics

    NARCIS (Netherlands)

    Groenendijk, J.; Roelofsen, F.; Larrazabal, J.M.; Zubeldia, L.

    2009-01-01

    This paper starts with an informal introduction to inquisitive semantics. After that, we present a formal definition of the semantics, and introduce the basic semantic notions of inquisitiveness and informativeness, in terms of wich we define the semantic categories of questions, assertions, and

  7. Semantic Web

    Directory of Open Access Journals (Sweden)

    Anna Lamandini

    2011-06-01

    Full Text Available The semantic Web is a technology at the service of knowledge which is aimed at accessibility and the sharing of content; facilitating interoperability between different systems and as such is one of the nine key technological pillars of TIC (technologies for information and communication within the third theme, programme specific cooperation of the seventh programme framework for research and development (7°PQRS, 2007-2013. As a system it seeks to overcome overload or excess of irrelevant information in Internet, in order to facilitate specific or pertinent research. It is an extension of the existing Web in which the aim is for cooperation between and the computer and people (the dream of Sir Tim Berners –Lee where machines can give more support to people when integrating and elaborating data in order to obtain inferences and a global sharing of data. It is a technology that is able to favour the development of a “data web” in other words the creation of a space in both sets of interconnected and shared data (Linked Data which allows users to link different types of data coming from different sources. It is a technology that will have great effect on everyday life since it will permit the planning of “intelligent applications” in various sectors such as education and training, research, the business world, public information, tourism, health, and e-government. It is an innovative technology that activates a social transformation (socio-semantic Web on a world level since it redefines the cognitive universe of users and enables the sharing not only of information but of significance (collective and connected intelligence.

  8. Geospatial semantic web

    CERN Document Server

    Zhang, Chuanrong; Li, Weidong

    2015-01-01

    This book covers key issues related to Geospatial Semantic Web, including geospatial web services for spatial data interoperability; geospatial ontology for semantic interoperability; ontology creation, sharing, and integration; querying knowledge and information from heterogeneous data source; interfaces for Geospatial Semantic Web, VGI (Volunteered Geographic Information) and Geospatial Semantic Web; challenges of Geospatial Semantic Web; and development of Geospatial Semantic Web applications. This book also describes state-of-the-art technologies that attempt to solve these problems such as WFS, WMS, RDF, OWL, and GeoSPARQL, and demonstrates how to use the Geospatial Semantic Web technologies to solve practical real-world problems such as spatial data interoperability.

  9. Semantics and expressiveness of ordered SOS

    NARCIS (Netherlands)

    Mousavi, M.R.; Phillips, I.C.C.; Reniers, M.A.; Ulidowski, I.

    2009-01-01

    Structured Operational Semantics (SOS) is a popular method for defining semantics by means of transition rules. An important feature of SOS rules is negative premises, which are crucial in the definitions of such phenomena as priority mechanisms and time-outs. However, the inclusion of negative

  10. UML Semantics FAQ: Dynamic Behaviour and Concurrency

    NARCIS (Netherlands)

    Wieringa, Roelf J.; Demeyer, Serge; Astesiano, Egidio; Reggio, Gianna; Le Guennec, Alain; Hussman, Heinrich; van den Berg, Klaas; van den Broek, P.M.

    This paper reports the results of a workshop held at ECOOP'99. The workshop was set up to find answers to questions fundamental to the definition of a semantics for the Unified Modelling Language. Questions examined the meaning of the term semantics in the context of UML; approaches to defining the

  11. Towards Semantic Interpretation of Movement Behavior

    NARCIS (Netherlands)

    Baglioni, M.; Macedo, J.; Renso, C.; Trasarti, R.; Wachowicz, M.

    2009-01-01

    In this paper we aim at providing a model for the conceptual representation and deductive reasoning of trajectory patterns obtained from mining raw trajectories. This has been achieved by means of a semantic enrichment process, where raw trajectories are enhanced with semantic information and

  12. Learning the Semantics of Structured Data Sources

    Science.gov (United States)

    Taheriyan, Mohsen

    2015-01-01

    Information sources such as relational databases, spreadsheets, XML, JSON, and Web APIs contain a tremendous amount of structured data, however, they rarely provide a semantic model to describe their contents. Semantic models of data sources capture the intended meaning of data sources by mapping them to the concepts and relationships defined by a…

  13. Semantique et psychologie (Semantics and Psychology)

    Science.gov (United States)

    Le Ny, Jean-Francois

    1975-01-01

    Semantic activities constitute a sub-class of psychological activities; from this point of departure the article discusses such topics as: idiosyncrasies, meaning and causality, internal determinants, neo-associationism, componential theories, noun- and verb-formation, sentences and propositions, semantics and cognition, mnemesic compontents, and…

  14. Semantics by analogy for illustrative volume visualization

    NARCIS (Netherlands)

    Gerl, Moritz; Rautek, Peter; Isenberg, Tobias; Groeller, Eduard

    We present an interactive graphical approach for the explicit specification of semantics for volume visualization. This explicit and graphical specification of semantics for volumetric features allows us to visually assign meaning to both input and output parameters of the visualization mapping.

  15. Adding Recursive Constructs to Bialgebraic Semantics

    DEFF Research Database (Denmark)

    Klin, Bartek

    2004-01-01

    This paper aims at fitting a general class of recursive equations into the framework of ‘well-behaved' structural operational semantics, formalized as bialgebraic semantics by Turi and Plotkin. Rather than interpreting recursive constructs by means of operational rules, separate recursive equatio...

  16. Evidence-Based Toxicology.

    Science.gov (United States)

    Hoffmann, Sebastian; Hartung, Thomas; Stephens, Martin

    Evidence-based toxicology (EBT) was introduced independently by two groups in 2005, in the context of toxicological risk assessment and causation as well as based on parallels between the evaluation of test methods in toxicology and evidence-based assessment of diagnostics tests in medicine. The role model of evidence-based medicine (EBM) motivated both proposals and guided the evolution of EBT, whereas especially systematic reviews and evidence quality assessment attract considerable attention in toxicology.Regarding test assessment, in the search of solutions for various problems related to validation, such as the imperfectness of the reference standard or the challenge to comprehensively evaluate tests, the field of Diagnostic Test Assessment (DTA) was identified as a potential resource. DTA being an EBM discipline, test method assessment/validation therefore became one of the main drivers spurring the development of EBT.In the context of pathway-based toxicology, EBT approaches, given their objectivity, transparency and consistency, have been proposed to be used for carrying out a (retrospective) mechanistic validation.In summary, implementation of more evidence-based approaches may provide the tools necessary to adapt the assessment/validation of toxicological test methods and testing strategies to face the challenges of toxicology in the twenty first century.

  17. Semantics and pragmatics.

    Science.gov (United States)

    McNally, Louise

    2013-05-01

    The fields of semantics and pragmatics are devoted to the study of conventionalized and context- or use-dependent aspects of natural language meaning, respectively. The complexity of human language as a semiotic system has led to considerable debate about how the semantics/pragmatics distinction should be drawn, if at all. This debate largely reflects contrasting views of meaning as a property of linguistic expressions versus something that speakers do. The fact that both views of meaning are essential to a complete understanding of language has led to a variety of efforts over the last 40 years to develop better integrated and more comprehensive theories of language use and interpretation. The most important advances have included the adaptation of propositional analyses of declarative sentences to interrogative, imperative and exclamative forms; the emergence of dynamic, game theoretic, and multi-dimensional theories of meaning; and the development of various techniques for incorporating context-dependent aspects of content into representations of context-invariant content with the goal of handling phenomena such as vagueness resolution, metaphor, and metonymy. WIREs Cogn Sci 2013, 4:285-297. doi: 10.1002/wcs.1227 For further resources related to this article, please visit the WIREs website. The authors declare no conflict of interest. Copyright © 2013 John Wiley & Sons, Ltd.

  18. Agenda of behavioral toxicology

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, B

    1978-01-01

    The author describes behavioral toxicology as a new discipline and contrasts it to the fields of physics and pharmacology. Several questions are raised and discussed concerning the field of behavioral toxicology. Some of these questions are: (1) how is an adverse behavioral effect recognized; (2) how can the non-specific be specified; (3) are standardized test batteries feasible. The problem of chronic intake is discussed as well as drawing information from other related disciplines such as neurochemistry, neuropathology and neurophysiology. The author concludes with several statements concerning new directions in the discipline of behavioral toxicology.

  19. [Clinical toxicology of the Academy: yesterday, today and tomorrow].

    Science.gov (United States)

    Sofronov, G A; Khalimov, Iu Sh; Matveev, S Iu; Kuz'mich, V G; Fomichev, A V

    2013-12-01

    National toxicology school of the Kirov Military Medical Academy, demonstrates the unity of clinical and experimental approaches related to one purpose throughout its history--saving human life and health from exposure to toxic substances of chemical nature. For more than three centuries the russian science of toxicology has been steadily developing, often ahead of the world science. It helped to create the means of protection and develop methods of treatment for chemical lesions. Currently, toxicology departments of military field therapy and military toxicology and medical protection are actively involved in the current study of military medicine, restructuring policy to provide toxicological aid in the Armed Forces, the development and introduction of Innovative methods of diagnosis and treatment of victims of toxicological etiology.

  20. Interpreting semantic clustering effects in free recall.

    Science.gov (United States)

    Manning, Jeremy R; Kahana, Michael J

    2012-07-01

    The order in which participants choose to recall words from a studied list of randomly selected words provides insights into how memories of the words are represented, organised, and retrieved. One pervasive finding is that when a pair of semantically related words (e.g., "cat" and "dog") is embedded in the studied list, the related words are often recalled successively. This tendency to successively recall semantically related words is termed semantic clustering (Bousfield, 1953; Bousfield & Sedgewick, 1944; Cofer, Bruce, & Reicher, 1966). Measuring semantic clustering effects requires making assumptions about which words participants consider to be similar in meaning. However, it is often difficult to gain insights into individual participants' internal semantic models, and for this reason researchers typically rely on standardised semantic similarity metrics. Here we use simulations to gain insights into the expected magnitudes of semantic clustering effects given systematic differences between participants' internal similarity models and the similarity metric used to quantify the degree of semantic clustering. Our results provide a number of useful insights into the interpretation of semantic clustering effects in free recall.

  1. Semantics of Kinship Terms in Tamil from the Semantic Typology Point of View

    Directory of Open Access Journals (Sweden)

    Анна Александровна Смирнитская

    2016-12-01

    Full Text Available In this article the author examines the lexical-semantic group “kinship terms” in Tamil, applying the attainments of modern semantic typology and the theory of semantic derivation. The kinship terms describing nuclear and extended family are explored. The “semantic shift” relation between two different meanings is established if such relation is realized by synchronous polysemy in one lexeme, semantic derivation, diachronic semantic change, cognates or some other means. The starting point of the study is the typological data from the DatSemShift catalogue of semantic shifts in languages of the world developed by a group of researchers under the guidance of Anna A. Zalizniak in the Institute of Linguistics, RAS. We verify the presence of semantic shifts described in the Database in Tamil. Also, we propose new semantic shifts specific only for this language. We confirm the presence of semantic relation of the studied type among the meanings with English “labels”: father - parents, girl - daughter, to deliver (a child - parents, - child, old woman - wife, owner - wife and others. The data also allows the assumption that the same relation exists between the meanings: old - grandfather, earth - mother, son - courage, unripe - son and others. The meanings of this field are the sources of semantic movements to abstract notions, lexicon of posession, forms of address and others; in addition many inner semantic relations inside this field are revealed. The meanings covering the nuclear part of the kinship system participate in universal semantic shifts described in the DatSemShift catalogue, while the meanings from collateral branches of this bifurcative kinship system (uncle, aunt turn out to be incomparable with kinship terms from indo-european lineal systems. Their meanings can be included in the DatSemShift catalogue only with an indication of system specifics. The information about semantic shifts can be useful for

  2. Scandinavian Semantics and the Human Body

    DEFF Research Database (Denmark)

    Levisen, Carsten

    2015-01-01

    , it is demonstrated that Scandinavian and English systems differ significantly in some aspects of the way in which the construe the human body with words. The study ventures an innovative combination of methods, pairing the Natural Semantic Metalanguage (NSM) approach to linguistic and conceptual analysis......This paper presents an ethnolinguistic analysis of how the space between the head and the body is construed in Scandinavian semantic systems vis-a-vis the semantic system of English. With an extensive case study of neck-related meanings in Danish, and with cross-Scandinavian reference...... with empirical evidence from the Evolution of Semantic Systems (EoSS) project. This combination of empirical and interpretative tools helps to integrate evidence from semantics and semiotics, pinning out in great detail the intricacies of the meanings of particular body words. The paper concludes that body words...

  3. Latent semantic analysis.

    Science.gov (United States)

    Evangelopoulos, Nicholas E

    2013-11-01

    This article reviews latent semantic analysis (LSA), a theory of meaning as well as a method for extracting that meaning from passages of text, based on statistical computations over a collection of documents. LSA as a theory of meaning defines a latent semantic space where documents and individual words are represented as vectors. LSA as a computational technique uses linear algebra to extract dimensions that represent that space. This representation enables the computation of similarity among terms and documents, categorization of terms and documents, and summarization of large collections of documents using automated procedures that mimic the way humans perform similar cognitive tasks. We present some technical details, various illustrative examples, and discuss a number of applications from linguistics, psychology, cognitive science, education, information science, and analysis of textual data in general. WIREs Cogn Sci 2013, 4:683-692. doi: 10.1002/wcs.1254 CONFLICT OF INTEREST: The author has declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website. © 2013 John Wiley & Sons, Ltd.

  4. Metabonomics and toxicology.

    Science.gov (United States)

    Zhao, Liang; Hartung, Thomas

    2015-01-01

    Being an emerging field of "omics" research, metabonomics has been increasingly used in toxicological studies mostly because this technology has the ability to provide more detailed information to elucidate mechanism of toxicity. As an interdisciplinary field of science, metabonomics combines analytical chemistry, bioinformatics, statistics, and biochemistry. When applied to toxicology, metabonomics also includes aspects of patho-biochemistry, systems biology, and molecular diagnostics. During a toxicological study, the metabolic changes over time and dose after chemical treatment can be monitored. Therefore, the most important use of this emerging technology is the identification of signatures of toxicity-patterns of metabolic changes predictive of a hazard manifestation. This chapter summarizes the current state of metabonomics technology and its applications in various areas of toxicological studies.

  5. Downloadable Computational Toxicology Data

    Science.gov (United States)

    EPA’s computational toxicology research generates data that investigates the potential harm, or hazard of a chemical, the degree of exposure to chemicals as well as the unique chemical characteristics. This data is publicly available here.

  6. Occupational medicine and toxicology

    Directory of Open Access Journals (Sweden)

    Fischer Axel

    2006-02-01

    Full Text Available Abstract This editorial is to announce the Journal of Occupational Medicine and Toxicology, a new Open Access, peer-reviewed, online journal published by BioMed Central. Occupational medicine and toxicology belong to the most wide ranging disciplines of all medical specialties. The field is devoted to the diagnosis, prevention, management and scientific analysis of diseases from the fields of occupational and environmental medicine and toxicology. It also covers the promotion of occupational and environmental health. The complexity of modern industrial processes has dramatically changed over the past years and today's areas include effects of atmospheric pollution, carcinogenesis, biological monitoring, ergonomics, epidemiology, product safety and health promotion. We hope that the launch of the Journal of Occupational Medicine and Toxicology will aid in the advance of these important areas of research bringing together multi-disciplinary research findings.

  7. The Two-Level Theory of Verb Meaning: An Approach to Integrating the Semantics of Action with the Mirror Neuron System

    Science.gov (United States)

    Kemmerer, David; Gonzalez-Castillo, Javier

    2010-01-01

    Verbs have two separate levels of meaning. One level reflects the uniqueness of every verb and is called the "root". The other level consists of a more austere representation that is shared by all the verbs in a given class and is called the "event structure template". We explore the following hypotheses about how, with specific reference to the…

  8. Progress in computational toxicology.

    Science.gov (United States)

    Ekins, Sean

    2014-01-01

    Computational methods have been widely applied to toxicology across pharmaceutical, consumer product and environmental fields over the past decade. Progress in computational toxicology is now reviewed. A literature review was performed on computational models for hepatotoxicity (e.g. for drug-induced liver injury (DILI)), cardiotoxicity, renal toxicity and genotoxicity. In addition various publications have been highlighted that use machine learning methods. Several computational toxicology model datasets from past publications were used to compare Bayesian and Support Vector Machine (SVM) learning methods. The increasing amounts of data for defined toxicology endpoints have enabled machine learning models that have been increasingly used for predictions. It is shown that across many different models Bayesian and SVM perform similarly based on cross validation data. Considerable progress has been made in computational toxicology in a decade in both model development and availability of larger scale or 'big data' models. The future efforts in toxicology data generation will likely provide us with hundreds of thousands of compounds that are readily accessible for machine learning models. These models will cover relevant chemistry space for pharmaceutical, consumer product and environmental applications. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. In silico toxicology protocols.

    Science.gov (United States)

    Myatt, Glenn J; Ahlberg, Ernst; Akahori, Yumi; Allen, David; Amberg, Alexander; Anger, Lennart T; Aptula, Aynur; Auerbach, Scott; Beilke, Lisa; Bellion, Phillip; Benigni, Romualdo; Bercu, Joel; Booth, Ewan D; Bower, Dave; Brigo, Alessandro; Burden, Natalie; Cammerer, Zoryana; Cronin, Mark T D; Cross, Kevin P; Custer, Laura; Dettwiler, Magdalena; Dobo, Krista; Ford, Kevin A; Fortin, Marie C; Gad-McDonald, Samantha E; Gellatly, Nichola; Gervais, Véronique; Glover, Kyle P; Glowienke, Susanne; Van Gompel, Jacky; Gutsell, Steve; Hardy, Barry; Harvey, James S; Hillegass, Jedd; Honma, Masamitsu; Hsieh, Jui-Hua; Hsu, Chia-Wen; Hughes, Kathy; Johnson, Candice; Jolly, Robert; Jones, David; Kemper, Ray; Kenyon, Michelle O; Kim, Marlene T; Kruhlak, Naomi L; Kulkarni, Sunil A; Kümmerer, Klaus; Leavitt, Penny; Majer, Bernhard; Masten, Scott; Miller, Scott; Moser, Janet; Mumtaz, Moiz; Muster, Wolfgang; Neilson, Louise; Oprea, Tudor I; Patlewicz, Grace; Paulino, Alexandre; Lo Piparo, Elena; Powley, Mark; Quigley, Donald P; Reddy, M Vijayaraj; Richarz, Andrea-Nicole; Ruiz, Patricia; Schilter, Benoit; Serafimova, Rositsa; Simpson, Wendy; Stavitskaya, Lidiya; Stidl, Reinhard; Suarez-Rodriguez, Diana; Szabo, David T; Teasdale, Andrew; Trejo-Martin, Alejandra; Valentin, Jean-Pierre; Vuorinen, Anna; Wall, Brian A; Watts, Pete; White, Angela T; Wichard, Joerg; Witt, Kristine L; Woolley, Adam; Woolley, David; Zwickl, Craig; Hasselgren, Catrin

    2018-04-17

    The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related predictions. This contribution articulates the information needed for protocols to support in silico predictions for major toxicological endpoints of concern (e.g., genetic toxicity, carcinogenicity, acute toxicity, reproductive toxicity, developmental toxicity) across several industries and regulatory bodies. Such novel in silico toxicology (IST) protocols, when fully developed and implemented, will ensure in silico toxicological assessments are performed and evaluated in a consistent, reproducible, and well-documented manner across industries and regulatory bodies to support wider uptake and acceptance of the approaches. The development of IST protocols is an initiative developed through a collaboration among an international consortium to reflect the state-of-the-art in in silico toxicology for hazard identification and characterization. A general outline for describing the development of such protocols is included and it is based on in silico predictions and/or available experimental data for a defined series of relevant toxicological effects or mechanisms. The publication presents a novel approach for determining the reliability of in silico predictions alongside experimental data. In addition, we discuss how to determine the level of confidence in the assessment based on the relevance and reliability of the information. Copyright © 2018. Published by Elsevier Inc.

  10. Towards semantic software engineering enviroments

    NARCIS (Netherlands)

    Falbo, R.A.; Guizzardi, G.; Natali, A.; Bertollo, G.; Ruy, F.; Mian, P.; Tortora, G.; Chang, S.K.

    2002-01-01

    Software tools processing partially common set of data should share an understanding of what these data mean. Since ontologies have been used to express formally a shared understanding of information, we argue that they are a way towards Semantic SEEs. In this paper we discuss an ontology-based

  11. Programming the semantic web

    CERN Document Server

    Segaran, Toby; Taylor, Jamie

    2009-01-01

    With this book, the promise of the Semantic Web -- in which machines can find, share, and combine data on the Web -- is not just a technical possibility, but a practical reality Programming the Semantic Web demonstrates several ways to implement semantic web applications, using current and emerging standards and technologies. You'll learn how to incorporate existing data sources into semantically aware applications and publish rich semantic data. Each chapter walks you through a single piece of semantic technology and explains how you can use it to solve real problems. Whether you're writing

  12. The semantic structure of gratitude

    Directory of Open Access Journals (Sweden)

    Smirnov, Alexander V.

    2016-06-01

    Full Text Available In the modern social and economic environment of Russia, gratitude might be considered an ambiguous phenomenon. It can have different meaning for a person in different contexts and can manifest itself differently as well (that is, as an expression of sincere feelings or as an element of corruption. In this respect it is topical to investigate the system of meanings and relationships that define the semantic space of gratitude. The goal of the study was the investigation and description of the content and structure of the semantic space of the gratitude phenomenon as well as the determination of male, female, age, and ethnic peculiarities of the expression of gratitude. The objective was achieved by using the semantic differential designed by the authors to investigate attitudes toward gratitude. This investigation was carried out with the participation of 184 respondents (Russians, Tatars, Ukrainians, Jews living in the Russian Federation, Belarus, Kazakhstan, Tajikistan, Israel, Australia, Canada, and the United Kingdom and identifying themselves as representatives of one of these nationalities. The structural components of gratitude were singled out by means of exploratory factor analysis of the empirical data from the designed semantic differential. Gender, age, and ethnic differences were differentiated by means of Student’s t-test. Gratitude can be represented by material and nonmaterial forms as well as by actions in response to help given. The empirical data allowed us to design the ethnically nonspecified semantic structure of gratitude. During the elaboration of the differential, semantic universals of gratitude, which constitute its psychosemantic content, were distinguished. Peculiarities of attitudes toward gratitude by those in different age and gender groups were revealed. Differences in the degree of manifestation of components of the psychosemantic structure of gratitude related to ethnic characteristics were not discovered

  13. Universal Dimensions of Meaning Derived from Semantic Relations among Words and Senses: Mereological Completeness vs. Ontological Generality (Open Access, Publisher’s Version)

    Science.gov (United States)

    2014-07-15

    Octopus 3.99 Reptilia −2.82 linolenic_acid 3.97 Dilleniidae −2.82 horseshoe_crab 3.94 Asteridae −2.78 Asian_horseshoe_crab 3.88 Eutheria −2.71...corresponds to a movement toward a definite meaning (e.g., more positive, or more exciting, or more abstract), but pairs of unrelated concepts can be found

  14. WEATHER FORECAST DATA SEMANTIC ANALYSIS IN F-LOGIC

    Directory of Open Access Journals (Sweden)

    Ana Meštrović

    2007-06-01

    Full Text Available This paper addresses the semantic analysis problem in a spoken dialog system developed for the domain of weather forecasts. The main goal of semantic analysis is to extract the meaning from the spoken utterances and to transform it into a domain database format. In this work a semantic database for the domain of weather forecasts is represented using the F-logic formalism. Semantic knowledge is captured through semantic categories a semantic dictionary using phrases and output templates. Procedures for semantic analysis of Croatian weather data combine parsing techniques for Croatian language and slot filling approach. Semantic analysis is conducted in three phases. In the first phase the main semantic category for the input utterance is determined. The lattices are used for hierarchical semantic relation representation and main category derivation. In the second phase semantic units are analyzed and knowledge slots in the database are filled. Since some slot values of input data are missing in the third phase, incomplete data is updated with missing values. All rules for semantic analysis are defined in the F-logic and implemented using the FLORA-2 system. The results of semantic analysis evaluation in terms of frame and slot error rates are presented.

  15. Word-embeddings Italian semantic spaces: A semantic model for psycholinguistic research

    Directory of Open Access Journals (Sweden)

    Marelli Marco

    2017-01-01

    Full Text Available Distributional semantics has been for long a source of successful models in psycholinguistics, permitting to obtain semantic estimates for a large number of words in an automatic and fast way. However, resources in this respect remain scarce or limitedly accessible for languages different from English. The present paper describes WEISS (Word-Embeddings Italian Semantic Space, a distributional semantic model based on Italian. WEISS includes models of semantic representations that are trained adopting state-of-the-art word-embeddings methods, applying neural networks to induce distributed representations for lexical meanings. The resource is evaluated against two test sets, demonstrating that WEISS obtains a better performance with respect to a baseline encoding word associations. Moreover, an extensive qualitative analysis of the WEISS output provides examples of the model potentialities in capturing several semantic phenomena. Two variants of WEISS are released and made easily accessible via web through the SNAUT graphic interface.

  16. Semantic Analysis of Fast Food Advertisement Slogans

    OpenAIRE

    Ginting, Enda Christiani Nora

    2017-01-01

    The aims of this study are to find out the types of meaning,and explain the ways of fast food advertisement slogans. This research is conducted by using descriptive qualitative design. The data are analyze by using The seven types of meaning is conducted by using Semantics (the study of meaning) theory by G. Leech (1983). The data are divided into Seven Types of meaning,they are; Conceptual meaning, Connotative meaning, Social meaning, Affective meaning, Reflected meaning, C...

  17. On the Existence of Semantic Working Memory: Evidence for Direct Semantic Maintenance

    Science.gov (United States)

    Shivde, Geeta; Anderson, Michael C.

    2011-01-01

    Despite widespread acknowledgment of the importance of online semantic maintenance, there has been astonishingly little work that clearly establishes this construct. We review the extant work relevant to short-term retention of meaning and show that, although consistent with semantic working memory, most data can be accommodated in other ways.…

  18. Systems Toxicology: Real World Applications and Opportunities

    Science.gov (United States)

    2017-01-01

    Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology entails the integration of in vitro and in vivo toxicity data with computational modeling. This evolving approach depends critically on data reliability and relevance, which in turn depends on the quality of experimental models and bioanalysis techniques used to generate toxicological data. Systems Toxicology involves the use of large-scale data streams (“big data”), such as those derived from omics measurements that require computational means for obtaining informative results. Thus, integrative analysis of multiple molecular measurements, particularly acquired by omics strategies, is a key approach in Systems Toxicology. In recent years, there have been significant advances centered on in vitro test systems and bioanalytical strategies, yet a frontier challenge concerns linking observed network perturbations to phenotypes, which will require understanding pathways and networks that give rise to adverse responses. This summary perspective from a 2016 Systems Toxicology meeting, an international conference held in the Alps of Switzerland, describes the limitations and opportunities of selected emerging applications in this rapidly advancing field. Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized, from empirical end points to pathways of toxicity. This requires the integration of in vitro and in vivo data with computational modeling. Test systems and bioanalytical technologies have made significant advances, but ensuring data reliability and relevance is an ongoing concern. The major challenge facing the new pathway approach is determining how to link observed network perturbations to phenotypic toxicity. PMID:28362102

  19. Systems Toxicology: Real World Applications and Opportunities.

    Science.gov (United States)

    Hartung, Thomas; FitzGerald, Rex E; Jennings, Paul; Mirams, Gary R; Peitsch, Manuel C; Rostami-Hodjegan, Amin; Shah, Imran; Wilks, Martin F; Sturla, Shana J

    2017-04-17

    Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology entails the integration of in vitro and in vivo toxicity data with computational modeling. This evolving approach depends critically on data reliability and relevance, which in turn depends on the quality of experimental models and bioanalysis techniques used to generate toxicological data. Systems Toxicology involves the use of large-scale data streams ("big data"), such as those derived from omics measurements that require computational means for obtaining informative results. Thus, integrative analysis of multiple molecular measurements, particularly acquired by omics strategies, is a key approach in Systems Toxicology. In recent years, there have been significant advances centered on in vitro test systems and bioanalytical strategies, yet a frontier challenge concerns linking observed network perturbations to phenotypes, which will require understanding pathways and networks that give rise to adverse responses. This summary perspective from a 2016 Systems Toxicology meeting, an international conference held in the Alps of Switzerland, describes the limitations and opportunities of selected emerging applications in this rapidly advancing field. Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized, from empirical end points to pathways of toxicity. This requires the integration of in vitro and in vivo data with computational modeling. Test systems and bioanalytical technologies have made significant advances, but ensuring data reliability and relevance is an ongoing concern. The major challenge facing the new pathway approach is determining how to link observed network perturbations to phenotypic toxicity.

  20. Retrieval from semantic memory.

    NARCIS (Netherlands)

    Noordman-Vonk, Wietske

    1977-01-01

    The present study has been concerned with the retrieval of semantic information. Retrieving semantic information is a fundamental process in almost any kind of cognitive behavior. The introduction presented the main experimental paradigms and results found in the literature on semantic memory as

  1. Towards Universal Semantic Tagging

    NARCIS (Netherlands)

    Abzianidze, Lasha; Bos, Johan

    2017-01-01

    The paper proposes the task of universal semantic tagging---tagging word tokens with language-neutral, semantically informative tags. We argue that the task, with its independent nature, contributes to better semantic analysis for wide-coverage multilingual text. We present the initial version of

  2. Aerospace Toxicology and Microbiology

    Science.gov (United States)

    James, John T.; Parmet, A. J.; Pierson, Duane L.

    2007-01-01

    Toxicology dates to the very earliest history of humanity with various poisons and venom being recognized as a method of hunting or waging war with the earliest documentation in the Evers papyrus (circa 1500 BCE). The Greeks identified specific poisons such as hemlock, a method of state execution, and the Greek word toxos (arrow) became the root of our modern science. The first scientific approach to the understanding of poisons and toxicology was the work during the late middle ages of Paracelsus. He formulated what were then revolutionary views that a specific toxic agent or "toxicon" caused specific dose-related effects. His principles have established the basis of modern pharmacology and toxicology. In 1700, Bernardo Ramazzini published the book De Morbis Artificum Diatriba (The Diseases of Workers) describing specific illnesses associated with certain labor, particularly metal workers exposed to mercury, lead, arsenic, and rock dust. Modern toxicology dates from development of the modern industrial chemical processes, the earliest involving an analytical method for arsenic by Marsh in 1836. Industrial organic chemicals were synthesized in the late 1800 s along with anesthetics and disinfectants. In 1908, Hamilton began the long study of occupational toxicology issues, and by WW I the scientific use of toxicants saw Haber creating war gases and defining time-dosage relationships that are used even today.

  3. Semantic annotation in biomedicine: the current landscape.

    Science.gov (United States)

    Jovanović, Jelena; Bagheri, Ebrahim

    2017-09-22

    The abundance and unstructured nature of biomedical texts, be it clinical or research content, impose significant challenges for the effective and efficient use of information and knowledge stored in such texts. Annotation of biomedical documents with machine intelligible semantics facilitates advanced, semantics-based text management, curation, indexing, and search. This paper focuses on annotation of biomedical entity mentions with concepts from relevant biomedical knowledge bases such as UMLS. As a result, the meaning of those mentions is unambiguously and explicitly defined, and thus made readily available for automated processing. This process is widely known as semantic annotation, and the tools that perform it are known as semantic annotators.Over the last dozen years, the biomedical research community has invested significant efforts in the development of biomedical semantic annotation technology. Aiming to establish grounds for further developments in this area, we review a selected set of state of the art biomedical semantic annotators, focusing particularly on general purpose annotators, that is, semantic annotation tools that can be customized to work with texts from any area of biomedicine. We also examine potential directions for further improvements of today's annotators which could make them even more capable of meeting the needs of real-world applications. To motivate and encourage further developments in this area, along the suggested and/or related directions, we review existing and potential practical applications and benefits of semantic annotators.

  4. Cancer and Toxicology Section

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    The Cancer and Toxicology Section is concerned with the investigation of the mechanisms by which chemicals, radiation, and viruses cause the changes broadly identified as cancer. In addition, the study of mechanisms has been extended to include the nontumorigenic effects of various agents associated with fossil energy and fuels. Research in molecular genetics of carcinogenesis focuses largely on the transposon properties of the genomes of retroviruses. The transposon structure of the DNA genomes of endogenous murine N-tropic and B-tropic type C retroviruses is being elucidated, and their chromosomal location mapped in hamster-mouse cell hybrids. A model of the mechanism of retrovirus induction by radiation and chemicals is being developed, and experiments have established that compounds such as hydroxyurea act as inducer. There is the possibility that transposition of sequences of this endogenous virus may be linked to leukemogenesis. Research in regulation of gene expression aims at defining in molecular terms the mechanisms determining expression of specific genes, how these are regulated by hormones, and the events responsible for dysfunction of gene expression in cancer. In corollary work, a library of cloned cDNAs specific for products of genes of special interest to regulation is being developed. Improvement of reversed-phase chromatography as a means of isolating bacterial plasmids and restriction fragments of DNA is underway. Newly developed techniques permit the isolation of supercoiled plasmid DNA directly from bacterial extracts. The technology has been developed recently for the photosynthetic growth of the chemo-autotrophic organism Rhodospirillum rubrum and the enzyme ribulosebisphosphate carboxylase has been produced in quantity

  5. Animal-free toxicology

    DEFF Research Database (Denmark)

    Knudsen, Lisbeth E

    2013-01-01

    Human data on exposure and adverse effects are the most appropriate for human risk assessment, and modern toxicology focuses on human pathway analysis and the development of human biomarkers. Human biomonitoring and human placental transport studies provide necessary information for human risk...... assessment, in accordance with the legislation on chemical, medicine and food safety. Toxicology studies based on human mechanistic and exposure information can replace animal studies. These animal-free approaches can be further supplemented by new in silico methods and chemical structure......-activity relationships. The inclusion of replacement expertise in the international Three Rs centres, the ongoing exploration of alternatives to animal research, and the improvement of conditions for research animals, all imply the beginning of a paradigm shift in toxicology research toward the use of human data....

  6. Evolution of toxicology information systems

    Energy Technology Data Exchange (ETDEWEB)

    Wassom, J.S.; Lu, P.Y. [Oak Ridge National Laboratory, TN (United States)

    1990-12-31

    Society today is faced with new health risk situations that have been brought about by recent scientific and technical advances. Federal and state governments are required to assess the many potential health risks to exposed populations from the products (chemicals) and by-products (pollutants) of these advances. Because a sound analysis of any potential health risk should be based on the use of relevant information, it behooves those individuals responsible for making the risk assessments to know where to obtain needed information. This paper reviews the origins of toxicology information systems and explores the specialized information center concept that was proposed in 1963 as a means of providing ready access to scientific and technical information. As a means of illustrating this concept, the operation of one specialized information center (the Environmental Mutagen Information Center at Oak Ridge National Laboratory) will be discussed. Insights into how toxicological information resources came into being, their design and makeup, will be of value to those seeking to acquire information for risk assessment purposes. 7 refs., 1 fig., 4 tabs.

  7. Shuttle Lesson Learned - Toxicology

    Science.gov (United States)

    James, John T.

    2010-01-01

    This is a script for a video about toxicology and the space shuttle. The first segment is deals with dust in the space vehicle. The next segment will be about archival samples. Then we'll look at real time on-board analyzers that give us a lot of capability in terms of monitoring for combustion products and the ability to monitor volatile organics on the station. Finally we will look at other issues that are about setting limits and dealing with ground based lessons that pertain to toxicology.

  8. Biomedical semantics in the Semantic Web.

    Science.gov (United States)

    Splendiani, Andrea; Burger, Albert; Paschke, Adrian; Romano, Paolo; Marshall, M Scott

    2011-03-07

    The Semantic Web offers an ideal platform for representing and linking biomedical information, which is a prerequisite for the development and application of analytical tools to address problems in data-intensive areas such as systems biology and translational medicine. As for any new paradigm, the adoption of the Semantic Web offers opportunities and poses questions and challenges to the life sciences scientific community: which technologies in the Semantic Web stack will be more beneficial for the life sciences? Is biomedical information too complex to benefit from simple interlinked representations? What are the implications of adopting a new paradigm for knowledge representation? What are the incentives for the adoption of the Semantic Web, and who are the facilitators? Is there going to be a Semantic Web revolution in the life sciences?We report here a few reflections on these questions, following discussions at the SWAT4LS (Semantic Web Applications and Tools for Life Sciences) workshop series, of which this Journal of Biomedical Semantics special issue presents selected papers from the 2009 edition, held in Amsterdam on November 20th.

  9. Semantically Interoperable XML Data.

    Science.gov (United States)

    Vergara-Niedermayr, Cristobal; Wang, Fusheng; Pan, Tony; Kurc, Tahsin; Saltz, Joel

    2013-09-01

    XML is ubiquitously used as an information exchange platform for web-based applications in healthcare, life sciences, and many other domains. Proliferating XML data are now managed through latest native XML database technologies. XML data sources conforming to common XML schemas could be shared and integrated with syntactic interoperability. Semantic interoperability can be achieved through semantic annotations of data models using common data elements linked to concepts from ontologies. In this paper, we present a framework and software system to support the development of semantic interoperable XML based data sources that can be shared through a Grid infrastructure. We also present our work on supporting semantic validated XML data through semantic annotations for XML Schema, semantic validation and semantic authoring of XML data. We demonstrate the use of the system for a biomedical database of medical image annotations and markups.

  10. Semantically Interoperable XML Data

    Science.gov (United States)

    Vergara-Niedermayr, Cristobal; Wang, Fusheng; Pan, Tony; Kurc, Tahsin; Saltz, Joel

    2013-01-01

    XML is ubiquitously used as an information exchange platform for web-based applications in healthcare, life sciences, and many other domains. Proliferating XML data are now managed through latest native XML database technologies. XML data sources conforming to common XML schemas could be shared and integrated with syntactic interoperability. Semantic interoperability can be achieved through semantic annotations of data models using common data elements linked to concepts from ontologies. In this paper, we present a framework and software system to support the development of semantic interoperable XML based data sources that can be shared through a Grid infrastructure. We also present our work on supporting semantic validated XML data through semantic annotations for XML Schema, semantic validation and semantic authoring of XML data. We demonstrate the use of the system for a biomedical database of medical image annotations and markups. PMID:25298789

  11. Semantic Frameworks

    DEFF Research Database (Denmark)

    Bergendorff, Steen

    2007-01-01

    This article departs from what has become known as Mekeo "sorcery" to argue that postfieldwork analysis should pay special attention to local organizations of meaning and how these are reflected in local practices. With this in mind, I first seek to eliminate Western notions from my field notes. ...

  12. Toxicología Vegetal

    OpenAIRE

    García Fernández, Antonio Juan

    2010-01-01

    Presentaciones de clase de los temas de Toxicología Vegetal de la licenciatura de Veterinaria de la Universidad de Murcia del curso 2011/12. Presentaciones de Toxicología Vegetal de la asignatura de Toxicología de la Licenciatura de Veterinaria del curso 2011/12

  13. Toxicological aspects of water

    International Nuclear Information System (INIS)

    Garcia Puertas, P.

    1991-01-01

    Different toxicological aspects of water have been studied, remarking the activity of various chemical substances in the organism. These substances are divided in: trace metals (Sb, As, Cd, Zn, Cu, Cr, Fe, Mn, Hg, Ni, Pb, Se), other contaminants (CN-, polycyclic aromatic hydrocarbons, phenols, pesticides, detergents) and radioactivity. Finally, some considerations on this subject are made [es

  14. The semantic sphere of juvenile offenders

    Directory of Open Access Journals (Sweden)

    Oshevsky D.S.

    2017-01-01

    Full Text Available The article presents the results of a preliminary empirical study aimed to identify features of the semantic sphere of adolescents who have committed illegal, including aggressive acts. The study included 50 male juveniles aged of 16 - 17 years. The first group consisted of adolescents convicted of aggressive and violent crimes; the second – of property socially dangerous acts (SDA. It is shown that evaluation of such adolescents is generally categorical and polar, the semantic field is subdifferentiable, less hierarchic, and has not enough realistic structure of meanings. Developed structure of motives and meanings is the basis of voluntary regulation of socially significant behavior. Thus, assessing the semantic sphere of juvenile offenders we can highlight its characteristics as risk factors of unlawful behavior, as well as the resource side, that will contribute to addressing issues of prevention and correction of unlawful behavior. Key words: juvenile offenders, semantic field of juvenile offenders, unlawful behavior.

  15. The Global Educational Toxicology Uniting Project (GETUP): an Analysis of the First Year of a Novel Toxicology Education Project.

    Science.gov (United States)

    Wong, Anselm; Vohra, Rais; Ruha, Anne-Michelle; Koutsogiannis, Zeff; Graeme, Kimberlie; Dargan, Paul I; Wood, David M; Greene, Shaun L

    2015-09-01

    The international boundaries to medical education are becoming less marked as new technologies such as multiuser videoconferencing are developed and become more accessible to help bridge the communication gaps. The Global Educational Toxicology Uniting Project (GETUP) is aimed at connecting clinicians in countries with established clinical toxicology services to clinicians in countries without clinical toxicologists around the globe. Centers that manage or consult on toxicology cases were registered through the American College of Medical Toxicology website via Survey Monkey®. Data was analyzed retrospectively from February 2014 to January 2015. Google hangouts® was used as the main conferencing software, but some sites preferred the use of Skype®. Registration data included contact details and toxicology background and qualifications. Thirty sites in 19 different countries in Australasia, Europe, Africa, and America were registered. Twenty-eight (93 %) sites were located in a major urban center, one (3.5 %) site in a major rural center and one (3.5 %) a private practice. Expectations of GETUP included sharing toxicology cases and education (30, 100 % of sites), assistance with toxicology management guidelines (2, 7 %), assistance with providing a toxicology teaching curriculum in languages other than English (2, 7 %), and managing toxicology presentations in resource-poor settings, international collaboration, and toxicovigilance (2 sites, 7 %). Twenty-two conferences were performed during the first 12 months with a mean of 3 cases per conference. GETUP has connected countries and clinical units with and without toxicology services and will provide a platform to improve international collaboration in clinical toxicology.

  16. SEMSIN SEMANTIC AND SYNTACTIC PARSER

    Directory of Open Access Journals (Sweden)

    K. K. Boyarsky

    2015-09-01

    Full Text Available The paper deals with the principle of operation for SemSin semantic and syntactic parser creating a dependency tree for the Russian language sentences. The parser consists of 4 blocks: a dictionary, morphological analyzer, production rules and lexical analyzer. An important logical part of the parser is pre-syntactical module, which harmonizes and complements morphological analysis results, separates the text paragraphs into individual sentences, and also carries out predisambiguation. Characteristic feature of the presented parser is an open type of control – it is done by means of a set of production rules. A varied set of commands provides the ability to both morphological and semantic-syntactic analysis of the sentence. The paper presents the sequence of rules usage and examples of their work. Specific feature of the rules is the decision making on establishment of syntactic links with simultaneous removal of the morphological and semantic ambiguity. The lexical analyzer provides the execution of commands and rules, and manages the parser in manual or automatic modes of the text analysis. In the first case, the analysis is performed interactively with the possibility of step-by-step execution of the rules and scanning the resulting parse tree. In the second case, analysis results are filed in an xml-file. Active usage of syntactic and semantic dictionary information gives the possibility to reduce significantly the ambiguity of parsing. In addition to marking the text, the parser is also usable as a tool for information extraction from natural language texts.

  17. Geospatial Semantics and the Semantic Web

    CERN Document Server

    Ashish, Naveen

    2011-01-01

    The availability of geographic and geospatial information and services, especially on the open Web has become abundant in the last several years with the proliferation of online maps, geo-coding services, geospatial Web services and geospatially enabled applications. The need for geospatial reasoning has significantly increased in many everyday applications including personal digital assistants, Web search applications, local aware mobile services, specialized systems for emergency response, medical triaging, intelligence analysis and more. Geospatial Semantics and the Semantic Web: Foundation

  18. Concurrent semantics for structured design methods

    OpenAIRE

    Nixon, Patrick

    1996-01-01

    Also in Jelly, I., Gordon, I., & Groll, P. Software Engineering for Parallel and Distributed Systems. London: Chapman Hall. Design methods can be ambiguous due to di#11;erent interpretations of symbols or concepts. This paper presents a formal semantics for the Ward/Mellor Structured Analysis Method for Real Time systems. These semantics ensures that an unambiguous meaning can be attributed to a particular design. Speci#12;cally, it ensures that concurrent and real-time propert...

  19. Meinongian Semantics and Artificial Intelligence

    Directory of Open Access Journals (Sweden)

    William J. Rapaport

    2013-12-01

    Full Text Available This essay describes computational semantic networks for a philosophical audience and surveys several approaches to semantic-network semantics. In particular, propositional semantic networks (exemplified by SNePS are discussed; it is argued that only a fully intensional, Meinongian semantics is appropriate for them; and several Meinongian systems are presented.

  20. Electrocortical N400 Effects of Semantic Satiation

    Directory of Open Access Journals (Sweden)

    Kim Ströberg

    2017-12-01

    Full Text Available Semantic satiation is characterised by the subjective and temporary loss of meaning after high repetition of a prime word. To study the nature of this effect, previous electroencephalography (EEG research recorded the N400, an ERP component that is sensitive to violations of semantic context. The N400 is characterised by a relative negativity to words that are unrelated vs. related to the semantic context. The semantic satiation hypothesis predicts that the N400 should decrease with high repetition. However, previous findings have been inconsistent. Because of these inconsistent findings and the shortcomings of previous research, we used a modified design that minimises confounding effects from non-semantic processes. We recorded 64-channel EEG and analysed the N400 in a semantic priming task in which the primes were repeated 3 or 30 times. Critically, we separated low and high repetition trials and excluded response trials. Further, we varied the physical features (letter case and format of consecutive primes to minimise confounding effects from perceptual habituation. For centrofrontal electrodes, the N400 was reduced after 30 repetitions (vs. 3 repetitions. Explorative source reconstructions suggested that activity decreased after 30 repetitions in bilateral inferior temporal gyrus, the right posterior section of the superior and middle temporal gyrus, right supramarginal gyrus, bilateral lateral occipital cortex, and bilateral lateral orbitofrontal cortex. These areas overlap broadly with those typically involved in the N400, namely middle temporal gyrus and inferior frontal gyrus. The results support the semantic rather than the perceptual nature of the satiation effect.

  1. Semantic framework for mapping object-oriented model to semantic web languages.

    Science.gov (United States)

    Ježek, Petr; Mouček, Roman

    2015-01-01

    The article deals with and discusses two main approaches in building semantic structures for electrophysiological metadata. It is the use of conventional data structures, repositories, and programming languages on one hand and the use of formal representations of ontologies, known from knowledge representation, such as description logics or semantic web languages on the other hand. Although knowledge engineering offers languages supporting richer semantic means of expression and technological advanced approaches, conventional data structures and repositories are still popular among developers, administrators and users because of their simplicity, overall intelligibility, and lower demands on technical equipment. The choice of conventional data resources and repositories, however, raises the question of how and where to add semantics that cannot be naturally expressed using them. As one of the possible solutions, this semantics can be added into the structures of the programming language that accesses and processes the underlying data. To support this idea we introduced a software prototype that enables its users to add semantically richer expressions into a Java object-oriented code. This approach does not burden users with additional demands on programming environment since reflective Java annotations were used as an entry for these expressions. Moreover, additional semantics need not to be written by the programmer directly to the code, but it can be collected from non-programmers using a graphic user interface. The mapping that allows the transformation of the semantically enriched Java code into the Semantic Web language OWL was proposed and implemented in a library named the Semantic Framework. This approach was validated by the integration of the Semantic Framework in the EEG/ERP Portal and by the subsequent registration of the EEG/ERP Portal in the Neuroscience Information Framework.

  2. The Semantic Web Revisited

    OpenAIRE

    Shadbolt, Nigel; Berners-Lee, Tim; Hall, Wendy

    2006-01-01

    The original Scientific American article on the Semantic Web appeared in 2001. It described the evolution of a Web that consisted largely of documents for humans to read to one that included data and information for computers to manipulate. The Semantic Web is a Web of actionable information--information derived from data through a semantic theory for interpreting the symbols.This simple idea, however, remains largely unrealized. Shopbots and auction bots abound on the Web, but these are esse...

  3. Applied Semantic Web Technologies

    CERN Document Server

    Sugumaran, Vijayan

    2011-01-01

    The rapid advancement of semantic web technologies, along with the fact that they are at various levels of maturity, has left many practitioners confused about the current state of these technologies. Focusing on the most mature technologies, Applied Semantic Web Technologies integrates theory with case studies to illustrate the history, current state, and future direction of the semantic web. It maintains an emphasis on real-world applications and examines the technical and practical issues related to the use of semantic technologies in intelligent information management. The book starts with

  4. Semantic web for dummies

    CERN Document Server

    Pollock, Jeffrey T

    2009-01-01

    Semantic Web technology is already changing how we interact with data on the Web. By connecting random information on the Internet in new ways, Web 3.0, as it is sometimes called, represents an exciting online evolution. Whether you're a consumer doing research online, a business owner who wants to offer your customers the most useful Web site, or an IT manager eager to understand Semantic Web solutions, Semantic Web For Dummies is the place to start! It will help you:Know how the typical Internet user will recognize the effects of the Semantic WebExplore all the benefits the data Web offers t

  5. Semantic Role Labeling

    CERN Document Server

    Palmer, Martha; Xue, Nianwen

    2011-01-01

    This book is aimed at providing an overview of several aspects of semantic role labeling. Chapter 1 begins with linguistic background on the definition of semantic roles and the controversies surrounding them. Chapter 2 describes how the theories have led to structured lexicons such as FrameNet, VerbNet and the PropBank Frame Files that in turn provide the basis for large scale semantic annotation of corpora. This data has facilitated the development of automatic semantic role labeling systems based on supervised machine learning techniques. Chapter 3 presents the general principles of applyin

  6. Phonological learning in semantic dementia.

    Science.gov (United States)

    Jefferies, Elizabeth; Bott, Samantha; Ehsan, Sheeba; Lambon Ralph, Matthew A

    2011-04-01

    Patients with semantic dementia (SD) have anterior temporal lobe (ATL) atrophy that gives rise to a highly selective deterioration of semantic knowledge. Despite pronounced anomia and poor comprehension of words and pictures, SD patients have well-formed, fluent speech and normal digit span. Given the intimate connection between phonological STM and word learning revealed by both neuropsychological and developmental studies, SD patients might be expected to show good acquisition of new phonological forms, even though their ability to map these onto meanings is impaired. In contradiction of these predictions, a limited amount of previous research has found poor learning of new phonological forms in SD. In a series of experiments, we examined whether SD patient, GE, could learn novel phonological sequences and, if so, under which circumstances. GE showed normal benefits of phonological knowledge in STM (i.e., normal phonotactic frequency and phonological similarity effects) but reduced support from semantic memory (i.e., poor immediate serial recall for semantically degraded words, characterised by frequent item errors). Next, we demonstrated normal learning of serial order information for repeated lists of single-digit number words using the Hebb paradigm: these items were well-understood allowing them to be repeated without frequent item errors. In contrast, patient GE showed little learning of nonsense syllable sequences using the same Hebb paradigm. Detailed analysis revealed that both GE and the controls showed a tendency to learn their own errors as opposed to the target items. Finally, we showed normal learning of phonological sequences for GE when he was prevented from repeating his errors. These findings confirm that the ATL atrophy in SD disrupts phonological processing for semantically degraded words but leaves the phonological architecture intact. Consequently, when item errors are minimised, phonological STM can support the acquisition of new phoneme

  7. Developmental toxicology: adequacy of current methods.

    Science.gov (United States)

    Peters, P W

    1998-01-01

    Toxicology embraces several disciplines such as carcinogenicity, mutagenicity and reproductive toxicity. Reproductive toxicology is concerned with possible effects of substances on the reproductive process, i.e. on sexual organs and their functions, endocrine regulation, fertilization, transport of the fertilized ovum, implantation, and embryonic, fetal and postnatal development, until the end-differentiation of the organs is achieved. Reproductive toxicology is divided into areas related to male and female fertility, and developmental toxicology. Developmental toxicology can be further broken down into prenatal and postnatal toxicology. Today, much new information is available about the origins of developmental disorders resulting from chemical exposure. While these findings seem to promise important new developments in methodology and research, there is a danger of losing sight of the precepts and principles established in the light of existing knowledge. There is also a danger that we may fail to correct shortcomings in our existing procedures and practice. The aim of this presentation is to emphasize the importance of testing substances for their impact in advance of their use and to underline that we must use the best existing tools for carrying out risk assessments. Moreover, it needs to be stressed that there are many substances that are never assessed with respect to reproductive and developmental toxicity. Similarly, our programmes for post-marketing surveillance with respect to developmental toxicology are grossly inadequate. Our ability to identify risks to normal development and reproduction would be much improved, first if a number of straightforward precepts were always followed and second, if we had a clearer understanding of what we mean by risk and acceptable levels of risk in the context of development. Other aims of this paper are: to stress the complexity of the different stages of normal prenatal development; to note the principles that are

  8. Veterinary Forensic Toxicology.

    Science.gov (United States)

    Gwaltney-Brant, S M

    2016-09-01

    Veterinary pathologists working in diagnostic laboratories are sometimes presented with cases involving animal poisonings that become the object of criminal or civil litigation. Forensic veterinary toxicology cases can include cases involving animal cruelty (malicious poisoning), regulatory issues (eg, contamination of the food supply), insurance litigation, or poisoning of wildlife. An understanding of the appropriate approach to these types of cases, including proper sample collection, handling, and transport, is essential so that chain of custody rules are followed and proper samples are obtained for toxicological analysis. Consultation with veterinary toxicologists at the diagnostic laboratory that will be processing the samples before, during, and after the forensic necropsy can help to ensure that the analytical tests performed are appropriate for the circumstances and findings surrounding the individual case. © The Author(s) 2016.

  9. Semantics by levels: An example for an image language

    International Nuclear Information System (INIS)

    Fasciano, M.; Levialdi, S.; Tortora, G.

    1984-01-01

    Ambiguities in formal language constructs may decrease both the understanding and the coding efficiency of a program. Within an image language, two semantic levels have been detected, corresponding to the lower level (pixel-based) and to the higher level (image-based). Denotational semantics has been used to define both levels within PIXAL (an image language) in order to enable the reader to visualize a concrete application of the semantic levels and their implications in a programming environment. This paper presents the semantics of different levels of conceptualization in the abstract formal description of an image language. The disambiguation of the meaning of special purpose constructs that imply either the elementary (pixels) level or the high image (array) level is naturally obtained by means of such semantic clauses. Perhaps non Von architectures on which hierarchical computations may be performed could also benefit from the use of semantic clauses to explicit the different levels where such computations are executed

  10. Toxicology of inorganic tin

    International Nuclear Information System (INIS)

    Burba, J.V.

    1982-01-01

    Tin(II) or stannous ion as a reducing agent is important in nuclear medicine because it is an essential component and common denominator for many in vivo radiodiagnostic agents, commonly called kits for the preparation of radiopharmaceuticals. This report is intended to alert nuclear medicine community regarding the wide range of biological effects that the stannous ion is capable of producing, and is a review of a large number of selected publications on the toxicological potential of tin(II)

  11. Operational Toxicology Research

    Science.gov (United States)

    2006-08-01

    techniques for perchlorate in water, groundwater, soil and biological matrices such as blood, urine, milk . thyroid and other tissues required for...toxicity when they are inhaled or ingested and they are irritating to the skin and mucus membranes (Committee on Toxicology, 1996). When compared to...the data collected. Develop analytical techniques for perchlorate in water, groundwater, soil, and biological matrices such as blood, urine, milk

  12. Morphological Cues for Lexical Semantics

    National Research Council Canada - National Science Library

    Light, Marc

    1996-01-01

    Most natural language processing tasks require lexical semantic information such as verbal argument structure and selectional restrictions, corresponding nominal semantic class, verbal aspectual class...

  13. Good cell culture practices &in vitro toxicology.

    Science.gov (United States)

    Eskes, Chantra; Boström, Ann-Charlotte; Bowe, Gerhard; Coecke, Sandra; Hartung, Thomas; Hendriks, Giel; Pamies, David; Piton, Alain; Rovida, Costanza

    2017-12-01

    Good Cell Culture Practices (GCCP) is of high relevance to in vitro toxicology. The European Society of Toxicology In Vitro (ESTIV), the Center for Alternatives for Animal Testing (CAAT) and the In Vitro Toxicology Industrial Platform (IVTIP) joined forces to address by means of an ESTIV 2016 pre-congress session the different aspects and applications of GCCP. The covered aspects comprised the current status of the OECD guidance document on Good In Vitro Method Practices, the importance of quality assurance for new technological advances in in vitro toxicology including stem cells, and the optimized implementation of Good Manufacturing Practices and Good Laboratory Practices for regulatory testing purposes. General discussions raised the duality related to the difficulties in implementing GCCP in an academic innovative research framework on one hand, and on the other hand, the need for such GCCP principles in order to ensure reproducibility and robustness of in vitro test methods for toxicity testing. Indeed, if good cell culture principles are critical to take into consideration for all uses of in vitro test methods for toxicity testing, the level of application of such principles may depend on the stage of development of the test method as well as on the applications of the test methods, i.e., academic innovative research vs. regulatory standardized test method. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Collection of biological samples in forensic toxicology.

    Science.gov (United States)

    Dinis-Oliveira, R J; Carvalho, F; Duarte, J A; Remião, F; Marques, A; Santos, A; Magalhães, T

    2010-09-01

    Forensic toxicology is the study and practice of the application of toxicology to the purposes of the law. The relevance of any finding is determined, in the first instance, by the nature and integrity of the specimen(s) submitted for analysis. This means that there are several specific challenges to select and collect specimens for ante-mortem and post-mortem toxicology investigation. Post-mortem specimens may be numerous and can endow some special difficulties compared to clinical specimens, namely those resulting from autolytic and putrefactive changes. Storage stability is also an important issue to be considered during the pre-analytic phase, since its consideration should facilitate the assessment of sample quality and the analytical result obtained from that sample. The knowledge on degradation mechanisms and methods to increase storage stability may enable the forensic toxicologist to circumvent possible difficulties. Therefore, advantages and limitations of specimen preservation procedures are thoroughfully discussed in this review. Presently, harmonized protocols for sampling in suspected intoxications would have obvious utility. In the present article an overview is given on sampling procedures for routinely collected specimens as well as on alternative specimens that may provide additional information on the route and timing of exposure to a specific xenobiotic. Last, but not least, a discussion on possible bias that can influence the interpretation of toxicological results is provided. This comprehensive review article is intented as a significant help for forensic toxicologists to accomplish their frequently overwhelming mission.

  15. Experience of Developing a Meta-Semantic Search Engine

    OpenAIRE

    Mukhopadhyay, Debajyoti; Sharma, Manoj; Joshi, Gajanan; Pagare, Trupti; Palwe, Adarsha

    2013-01-01

    Thinking of todays web search scenario which is mainly keyword based, leads to the need of effective and meaningful search provided by Semantic Web. Existing search engines are vulnerable to provide relevant answers to users query due to their dependency on simple data available in web pages. On other hand, semantic search engines provide efficient and relevant results as the semantic web manages information with well defined meaning using ontology. A Meta-Search engine is a search tool that ...

  16. Intelligent Agent Based Semantic Web in Cloud Computing Environment

    OpenAIRE

    Mukhopadhyay, Debajyoti; Sharma, Manoj; Joshi, Gajanan; Pagare, Trupti; Palwe, Adarsha

    2013-01-01

    Considering today's web scenario, there is a need of effective and meaningful search over the web which is provided by Semantic Web. Existing search engines are keyword based. They are vulnerable in answering intelligent queries from the user due to the dependence of their results on information available in web pages. While semantic search engines provides efficient and relevant results as the semantic web is an extension of the current web in which information is given well defined meaning....

  17. Toxicological Benchmarks for Wildlife

    Energy Technology Data Exchange (ETDEWEB)

    Sample, B.E. Opresko, D.M. Suter, G.W.

    1993-01-01

    Ecological risks of environmental contaminants are evaluated by using a two-tiered process. In the first tier, a screening assessment is performed where concentrations of contaminants in the environment are compared to no observed adverse effects level (NOAEL)-based toxicological benchmarks. These benchmarks represent concentrations of chemicals (i.e., concentrations presumed to be nonhazardous to the biota) in environmental media (water, sediment, soil, food, etc.). While exceedance of these benchmarks does not indicate any particular level or type of risk, concentrations below the benchmarks should not result in significant effects. In practice, when contaminant concentrations in food or water resources are less than these toxicological benchmarks, the contaminants may be excluded from further consideration. However, if the concentration of a contaminant exceeds a benchmark, that contaminant should be retained as a contaminant of potential concern (COPC) and investigated further. The second tier in ecological risk assessment, the baseline ecological risk assessment, may use toxicological benchmarks as part of a weight-of-evidence approach (Suter 1993). Under this approach, based toxicological benchmarks are one of several lines of evidence used to support or refute the presence of ecological effects. Other sources of evidence include media toxicity tests, surveys of biota (abundance and diversity), measures of contaminant body burdens, and biomarkers. This report presents NOAEL- and lowest observed adverse effects level (LOAEL)-based toxicological benchmarks for assessment of effects of 85 chemicals on 9 representative mammalian wildlife species (short-tailed shrew, little brown bat, meadow vole, white-footed mouse, cottontail rabbit, mink, red fox, and whitetail deer) or 11 avian wildlife species (American robin, rough-winged swallow, American woodcock, wild turkey, belted kingfisher, great blue heron, barred owl, barn owl, Cooper's hawk, and red

  18. Quality of semantic standards

    NARCIS (Netherlands)

    Folmer, Erwin Johan Albert

    2012-01-01

    Little scientific literature addresses the issue of quality of semantic standards, albeit a problem with high economic and social impact. Our problem survey, including 34 semantic Standard Setting Organizations (SSOs), gives evidence that quality of standards can be improved, but for improvement a

  19. Semantic Business Process Modeling

    OpenAIRE

    Markovic, Ivan

    2010-01-01

    This book presents a process-oriented business modeling framework based on semantic technologies. The framework consists of modeling languages, methods, and tools that allow for semantic modeling of business motivation, business policies and rules, and business processes. Quality of the proposed modeling framework is evaluated based on the modeling content of SAP Solution Composer and several real-world business scenarios.

  20. Semantic Web Primer

    NARCIS (Netherlands)

    Antoniou, Grigoris; Harmelen, Frank van

    2004-01-01

    The development of the Semantic Web, with machine-readable content, has the potential to revolutionize the World Wide Web and its use. A Semantic Web Primer provides an introduction and guide to this still emerging field, describing its key ideas, languages, and technologies. Suitable for use as a

  1. Pragmatics for formal semantics

    DEFF Research Database (Denmark)

    Danvy, Olivier

    2011-01-01

    This tech talk describes how to write and how to inter-derive formal semantics for sequential programming languages. The progress reported here is (1) concrete guidelines to write each formal semantics to alleviate their proof obligations, and (2) simple calculational tools to obtain a formal...

  2. A reasonable Semantic Web

    NARCIS (Netherlands)

    Hitzler, Pascal; Van Harmelen, Frank

    2010-01-01

    The realization of Semantic Web reasoning is central to substantiating the Semantic Web vision. However, current mainstream research on this topic faces serious challenges, which forces us to question established lines of research and to rethink the underlying approaches. We argue that reasoning for

  3. Semantic Web status model

    CSIR Research Space (South Africa)

    Gerber, AJ

    2006-06-01

    Full Text Available Semantic Web application areas are experiencing intensified interest due to the rapid growth in the use of the Web, together with the innovation and renovation of information content technologies. The Semantic Web is regarded as an integrator across...

  4. Summary introduction to environmental toxicology

    International Nuclear Information System (INIS)

    Heinzow, B.; Jessen, H.; Wendorff, D.

    1986-01-01

    The increasing environmental consciousness and the increasing public interest in environmental medicine and toxicology is much appreciated by the Research Institute for Environmental Toxicology. This information brochure gives the reader some insight into the importance of environmental toxicology and into the waste of the Research Institute. In response to the current situation, the authors have included an appendix on radiation protection. (orig./PW) [de

  5. A study of expertise effects for products with contradictory semantics

    Directory of Open Access Journals (Sweden)

    Wang Ching-Yi

    2017-01-01

    Full Text Available In the design studies, researchers often use the semantic differential method with bipolar adjectives, such as “modern vs. classical” or “simple vs. complex” when investigating the semantics projected by product forms. However, in design practice, some design examples clearly exhibit the simultaneous use of contradictory meanings in product semantics. For example, retro car evokes nostalgia by borrowing characteristics from classical cars. At the same time it exhibits a modern style. However, most studies measure the product semantics mostly by using subjective measurement. There is lack objective measurement for that. In this research, we examined the results of applying the semantic differential method to measure contradiction in product semantics. The results showed that the distributions of semantic differential ratings for the stimuli with contradictory meanings have higher standard deviations. The sensitivity of semantic recognition may depend on participant expertise. The design experts are trained to be good at visual thinking that could easily identify the contradiction semantics between products. In general, successful embedding of contradictory meanings into product forms are based on simple, typical, and rational forms that can display complex, novel, and perceptual images by adding supplementary elements.

  6. High Throughput Transcriptomics @ USEPA (Toxicology ...

    Science.gov (United States)

    The ideal chemical testing approach will provide complete coverage of all relevant toxicological responses. It should be sensitive and specific It should identify the mechanism/mode-of-action (with dose-dependence). It should identify responses relevant to the species of interest. Responses should ideally be translated into tissue-, organ-, and organism-level effects. It must be economical and scalable. Using a High Throughput Transcriptomics platform within US EPA provides broader coverage of biological activity space and toxicological MOAs and helps fill the toxicological data gap. Slide presentation at the 2016 ToxForum on using High Throughput Transcriptomics at US EPA for broader coverage biological activity space and toxicological MOAs.

  7. Semantic Web and Contextual Information: Semantic Network Analysis of Online Journalistic Texts

    Science.gov (United States)

    Lim, Yon Soo

    This study examines why contextual information is important to actualize the idea of semantic web, based on a case study of a socio-political issue in South Korea. For this study, semantic network analyses were conducted regarding English-language based 62 blog posts and 101 news stories on the web. The results indicated the differences of the meaning structures between blog posts and professional journalism as well as between conservative journalism and progressive journalism. From the results, this study ascertains empirical validity of current concerns about the practical application of the new web technology, and discusses how the semantic web should be developed.

  8. A Semantic and Pragmatic Analyses of Igbo Names

    African Journals Online (AJOL)

    Key words: personal names, Igbo, semantic content, pragmatic content, structure. Background to the Study ... Igbo name is a story, a book or a dictionary itself. ..... the meaning (literal meaning) of some of the data structurally presented above.

  9. ACToR-AGGREGATED COMPUTATIONAL TOXICOLOGY ...

    Science.gov (United States)

    One goal of the field of computational toxicology is to predict chemical toxicity by combining computer models with biological and toxicological data. predict chemical toxicity by combining computer models with biological and toxicological data

  10. Semantics by analogy for illustrative volume visualization☆

    Science.gov (United States)

    Gerl, Moritz; Rautek, Peter; Isenberg, Tobias; Gröller, Eduard

    2012-01-01

    We present an interactive graphical approach for the explicit specification of semantics for volume visualization. This explicit and graphical specification of semantics for volumetric features allows us to visually assign meaning to both input and output parameters of the visualization mapping. This is in contrast to the implicit way of specifying semantics using transfer functions. In particular, we demonstrate how to realize a dynamic specification of semantics which allows to flexibly explore a wide range of mappings. Our approach is based on three concepts. First, we use semantic shader augmentation to automatically add rule-based rendering functionality to static visualization mappings in a shader program, while preserving the visual abstraction that the initial shader encodes. With this technique we extend recent developments that define a mapping between data attributes and visual attributes with rules, which are evaluated using fuzzy logic. Second, we let users define the semantics by analogy through brushing on renderings of the data attributes of interest. Third, the rules are specified graphically in an interface that provides visual clues for potential modifications. Together, the presented methods offer a high degree of freedom in the specification and exploration of rule-based mappings and avoid the limitations of a linguistic rule formulation. PMID:23576827

  11. Usage of semantic representations in recognition memory.

    Science.gov (United States)

    Nishiyama, Ryoji; Hirano, Tetsuji; Ukita, Jun

    2017-11-01

    Meanings of words facilitate false acceptance as well as correct rejection of lures in recognition memory tests, depending on the experimental context. This suggests that semantic representations are both directly and indirectly (i.e., mediated by perceptual representations) used in remembering. Studies using memory conjunction errors (MCEs) paradigms, in which the lures consist of component parts of studied words, have reported semantic facilitation of rejection of the lures. However, attending to components of the lures could potentially cause this. Therefore, we investigated whether semantic overlap of lures facilitates MCEs using Japanese Kanji words in which a whole-word image is more concerned in reading. Experiments demonstrated semantic facilitation of MCEs in a delayed recognition test (Experiment 1), and in immediate recognition tests in which participants were prevented from using phonological or orthographic representations (Experiment 2), and the salient effect on individuals with high semantic memory capacities (Experiment 3). Additionally, analysis of the receiver operating characteristic suggested that this effect is attributed to familiarity-based memory judgement and phantom recollection. These findings indicate that semantic representations can be directly used in remembering, even when perceptual representations of studied words are available.

  12. Postmortem Biochemistry and Toxicology

    Directory of Open Access Journals (Sweden)

    Robert Flanagan

    2017-04-01

    Full Text Available The aim of postmortem biochemistry and toxicology is either to help establish the cause of death, or to gain information on events immediately before death. If self-poisoning is suspected, the diagnosis may be straightforward and all that could be required is confirmation of the agents involved. However, if the cause of death is not immediately obvious then suspicion of possible poisoning or of conditions such as alcoholic ketoacidosis is of course crucial. On the other hand, it may be important to investigate adherence to prescribed therapy, for example with anticonvulsants or antipsychotics, hence sensitive methods are required. Blood sampling (needle aspiration, peripheral vein, for example femoral, ideally after proximal ligation before opening the body minimizes the risk of sample contamination with, for example, gut contents or urine. Other specimens (stomach contents, urine, liver, vitreous humor may also be valuable and may be needed to corroborate unexpected or unusual findings in the absence of other evidence. The site of sampling should always be recorded. The availability of antemortem specimens should not necessarily preclude postmortem sampling. Appropriate sample preservation, transport, and storage are mandatory. Interpretation of analytical toxicology results must take into account what is known of the pharmacokinetics and toxicology of the agent(s in question, the circumstances under which death occurred including the mechanism of exposure, and other factors such as the stability of the analyte(s and the analytical methods used. It is important to realise that changes may occur in the composition of body fluids, even peripheral blood, after death. Such changes are likely to be greater after attempted resuscitation, and with centrally-acting drugs with large volumes of distribution given chronically, and may perhaps be minimised by prompt refrigeration of the body and performing the autopsy quickly.

  13. Concealed semantic and episodic autobiographical memory electrified

    Directory of Open Access Journals (Sweden)

    Giorgio eGanis

    2013-01-01

    Full Text Available Electrophysiology-based concealed information tests (CIT try to determine whether somebody possesses concealed information about a probe item by comparing event-related potentials (ERPs between this item and comparison items (irrelevants. Although the broader field is sometimes referred to as memory detection, little attention has been paid to the precise type of underlying memory involved. This study begins addressing this issue by examining the key distinction between semantic and episodic memory in the autobiographical domain within a CIT paradigm. This study also addressed the issue of whether multiple repetitions of the items over the course of the session habituate the brain responses. Participants were tested in a 3-stimulus CIT with semantic autobiographical probes (their own date of birth and episodic autobiographical probes (a secret date learned just before the study. Results dissociated these two memory conditions on several ERP components. Semantic probes elicited a smaller frontal N2 than episodic probes, consistent with the idea that the frontal N2 decreases with greater pre-existing semantic knowledge about the item. Likewise, semantic probes elicited a smaller central N400 than episodic probes. Semantic probes also elicited a larger P3b than episodic probes because of their richer meaning. In contrast, episodic probes elicited a larger late positive component (LPC than semantic probes, because of the recent episodic memory associated with them. All these ERPs showed a difference between probes and irrelevants in both memory conditions, except for the N400, which showed a difference only in the semantic condition. Finally, although repetition affected the ERPs, it did not reduce the difference between probes and irrelevants. Thus, the type of memory associated with a probe has both theoretical and practical importance for CIT research.

  14. Toxicology of freshwater cyanobacteria.

    Science.gov (United States)

    Liyanage, H M; Arachchi, D N Magana; Abeysekara, T; Guneratne, L

    2016-07-02

    Many chemical contaminants in drinking water have been shown to cause adverse health effects in humans after prolonged exposure. Cyanobacteria are one of the most potent and diverse groups of photosynthetic prokaryotes. One key component of cyanobacterial success in the environment is the production of potent toxins as secondary metabolites, which have been responsible for numerous adverse health impacts in humans. Anthropogenic activities have led to the increase of eutrophication in freshwater bodies' worldwide, causing cyanobacterial blooms to become more frequent. The present article will discuss about harmful cyanobacteria and their toxicology with special references to microcystin, nodularin, and cylindrospermopsin.

  15. Pharmacogenetics and forensic toxicology.

    Science.gov (United States)

    Musshoff, Frank; Stamer, Ulrike M; Madea, Burkhard

    2010-12-15

    Large inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with its target often are determined by genetic differences. Pharmacokinetic and pharmacodynamic variations can appear at the level of drug metabolizing enzymes (e.g., the cytochrome P450 system), drug transporters, drug targets or other biomarker genes. Pharmacogenetics or toxicogenetics can therefore be relevant in forensic toxicology. This review presents relevant aspects together with some examples from daily routines. Copyright © 2010. Published by Elsevier Ireland Ltd.

  16. The meaning of ordered SOS

    NARCIS (Netherlands)

    Mousavi, M.R.; Phillips, I.C.C.; Reniers, M.A.; Ulidowski, I.; Arun-Kumar, S.; Garg, N.

    2006-01-01

    Structured Operational Semantics (SOS) is a popular method for defining semantics by means of deduction rules. An important feature of deduction rules, or simply SOS rules, are negative premises, which are crucial in the definitions of such phenomena as priority mechanisms and time-outs. Orderings

  17. Translational toxicology: a developmental focus for integrated research strategies.

    Science.gov (United States)

    Hughes, Claude; Waters, Michael; Allen, David; Obasanjo, Iyabo

    2013-09-30

    Given that toxicology studies the potential adverse effects of environmental exposures on various forms of life and that clinical toxicology typically focuses on human health effects, what can and should the relatively new term of "translational toxicology" be taken to mean? Our assertion is that the core concept of translational toxicology must incorporate existing principles of toxicology and epidemiology, but be driven by the aim of developing safe and effective interventions beyond simple reduction or avoidance of exposure to prevent, mitigate or reverse adverse human health effects of exposures.The field of toxicology has now reached a point where advances in multiple areas of biomedical research and information technologies empower us to make fundamental transitions in directly impacting human health. Translational toxicology must encompass four action elements as follows: 1) Assessing human exposures in critical windows across the lifespan; 2) Defining modes of action and relevance of data from animal models; 3) Use of mathematical models to develop plausible predictions as the basis for: 4) Protective and restorative human health interventions. The discussion focuses on the critical window of in-utero development. Exposure assessment, basic toxicology and development of certain categories of mathematical models are not new areas of research; however overtly integrating these in order to conceive, assess and validate effective interventions to mitigate or reverse adverse effects of environmental exposures is our novel opportunity. This is what we should do in translational toxicology so that we have a portfolio of interventional options to improve human health that include both minimizing exposures and specific preventative/restorative/mitigative therapeutics.

  18. A Defense of Semantic Minimalism

    Science.gov (United States)

    Kim, Su

    2012-01-01

    Semantic Minimalism is a position about the semantic content of declarative sentences, i.e., the content that is determined entirely by syntax. It is defined by the following two points: "Point 1": The semantic content is a complete/truth-conditional proposition. "Point 2": The semantic content is useful to a theory of…

  19. Basic semantics of product sounds

    NARCIS (Netherlands)

    Özcan Vieira, E.; Van Egmond, R.

    2012-01-01

    Product experience is a result of sensory and semantic experiences with product properties. In this paper, we focus on the semantic attributes of product sounds and explore the basic components for product sound related semantics using a semantic differential paradigmand factor analysis. With two

  20. Arabic web pages clustering and annotation using semantic class features

    Directory of Open Access Journals (Sweden)

    Hanan M. Alghamdi

    2014-12-01

    Full Text Available To effectively manage the great amount of data on Arabic web pages and to enable the classification of relevant information are very important research problems. Studies on sentiment text mining have been very limited in the Arabic language because they need to involve deep semantic processing. Therefore, in this paper, we aim to retrieve machine-understandable data with the help of a Web content mining technique to detect covert knowledge within these data. We propose an approach to achieve clustering with semantic similarities. This approach comprises integrating k-means document clustering with semantic feature extraction and document vectorization to group Arabic web pages according to semantic similarities and then show the semantic annotation. The document vectorization helps to transform text documents into a semantic class probability distribution or semantic class density. To reach semantic similarities, the approach extracts the semantic class features and integrates them into the similarity weighting schema. The quality of the clustering result has evaluated the use of the purity and the mean intra-cluster distance (MICD evaluation measures. We have evaluated the proposed approach on a set of common Arabic news web pages. We have acquired favorable clustering results that are effective in minimizing the MICD, expanding the purity and lowering the runtime.

  1. Benchmarking semantic web technology

    CERN Document Server

    García-Castro, R

    2009-01-01

    This book addresses the problem of benchmarking Semantic Web Technologies; first, from a methodological point of view, proposing a general methodology to follow in benchmarking activities over Semantic Web Technologies and, second, from a practical point of view, presenting two international benchmarking activities that involved benchmarking the interoperability of Semantic Web technologies using RDF(S) as the interchange language in one activity and OWL in the other.The book presents in detail how the different resources needed for these interoperability benchmarking activities were defined:

  2. Reactive Kripke semantics

    CERN Document Server

    Gabbay, Dov M

    2013-01-01

    This text offers an extension to the traditional Kripke semantics for non-classical logics by adding the notion of reactivity. Reactive Kripke models change their accessibility relation as we progress in the evaluation process of formulas in the model. This feature makes the reactive Kripke semantics strictly stronger and more applicable than the traditional one. Here we investigate the properties and axiomatisations of this new and most effective semantics, and we offer a wide landscape of applications of the idea of reactivity. Applied topics include reactive automata, reactive grammars, rea

  3. UML 2 Semantics and Applications

    CERN Document Server

    Lano, Kevin

    2009-01-01

    A coherent and integrated account of the leading UML 2 semantics work and the practical applications of UML semantics development With contributions from leading experts in the field, the book begins with an introduction to UML and goes on to offer in-depth and up-to-date coverage of: The role of semantics Considerations and rationale for a UML system model Definition of the UML system model UML descriptive semantics Axiomatic semantics of UML class diagrams The object constraint language Axiomatic semantics of state machines A coalgebraic semantic framework for reasoning about interaction des

  4. Translational semantics: A discussion of the second edition of ...

    African Journals Online (AJOL)

    Translational semantics: A discussion of the second edition of Geoffrey Leech's Semantics: the Study of Meaning. N Love. Abstract. No abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.5774/11-0-106 · AJOL African Journals ...

  5. Ontology-Based Information Visualization: Toward Semantic Web Applications

    NARCIS (Netherlands)

    Fluit, Christiaan; Sabou, Marta; Harmelen, Frank van

    2006-01-01

    The Semantic Web is an extension of the current World Wide Web, based on the idea of exchanging information with explicit, formal, and machine-accessible descriptions of meaning. Providing information with such semantics will enable the construction of applications that have an increased awareness

  6. Analysis of Statistical Methods Currently used in Toxicology Journals.

    Science.gov (United States)

    Na, Jihye; Yang, Hyeri; Bae, SeungJin; Lim, Kyung-Min

    2014-09-01

    Statistical methods are frequently used in toxicology, yet it is not clear whether the methods employed by the studies are used consistently and conducted based on sound statistical grounds. The purpose of this paper is to describe statistical methods used in top toxicology journals. More specifically, we sampled 30 papers published in 2014 from Toxicology and Applied Pharmacology, Archives of Toxicology, and Toxicological Science and described methodologies used to provide descriptive and inferential statistics. One hundred thirteen endpoints were observed in those 30 papers, and most studies had sample size less than 10, with the median and the mode being 6 and 3 & 6, respectively. Mean (105/113, 93%) was dominantly used to measure central tendency, and standard error of the mean (64/113, 57%) and standard deviation (39/113, 34%) were used to measure dispersion, while few studies provide justifications regarding why the methods being selected. Inferential statistics were frequently conducted (93/113, 82%), with one-way ANOVA being most popular (52/93, 56%), yet few studies conducted either normality or equal variance test. These results suggest that more consistent and appropriate use of statistical method is necessary which may enhance the role of toxicology in public health.

  7. Semantic Web Technologies for the Adaptive Web

    DEFF Research Database (Denmark)

    Dolog, Peter; Nejdl, Wolfgang

    2007-01-01

    Ontologies and reasoning are the key terms brought into focus by the semantic web community. Formal representation of ontologies in a common data model on the web can be taken as a foundation for adaptive web technologies as well. This chapter describes how ontologies shared on the semantic web...... provide conceptualization for the links which are a main vehicle to access information on the web. The subject domain ontologies serve as constraints for generating only those links which are relevant for the domain a user is currently interested in. Furthermore, user model ontologies provide additional...... means for deciding which links to show, annotate, hide, generate, and reorder. The semantic web technologies provide means to formalize the domain ontologies and metadata created from them. The formalization enables reasoning for personalization decisions. This chapter describes which components...

  8. Algebraic Semantics for Narrative

    Science.gov (United States)

    Kahn, E.

    1974-01-01

    This paper uses discussion of Edmund Spenser's "The Faerie Queene" to present a theoretical framework for explaining the semantics of narrative discourse. The algebraic theory of finite automata is used. (CK)

  9. Semantic Web Development

    National Research Council Canada - National Science Library

    Berners-Lee, Tim; Swick, Ralph

    2006-01-01

    ...) project between 2002 and 2005 provided key steps in the research in the Semantic Web technology, and also played an essential role in delivering the technology to industry and government in the form...

  10. A Semantic Prosody Analysis of Three Adjective Synonymous Pairs in COCA

    Science.gov (United States)

    Hu, H. C. Marcella

    2015-01-01

    Over the past two decades the concept of semantic prosody has attracted considerable research interest since Sinclair (1991) observed that "many uses of words and phrases show a tendency to occur in a certain semantic environment" (p. 112). Sinclair (2003) also noted that semantic prosody conveys its pragmatic meaning and attitudinal…

  11. Neural correlates of concreteness in semantic categorization.

    Science.gov (United States)

    Pexman, Penny M; Hargreaves, Ian S; Edwards, Jodi D; Henry, Luke C; Goodyear, Bradley G

    2007-08-01

    In some contexts, concrete words (CARROT) are recognized and remembered more readily than abstract words (TRUTH). This concreteness effect has historically been explained by two theories of semantic representation: dual-coding [Paivio, A. Dual coding theory: Retrospect and current status. Canadian Journal of Psychology, 45, 255-287, 1991] and context-availability [Schwanenflugel, P. J. Why are abstract concepts hard to understand? In P. J. Schwanenflugel (Ed.), The psychology of word meanings (pp. 223-250). Hillsdale, NJ: Erlbaum, 1991]. Past efforts to adjudicate between these theories using functional magnetic resonance imaging have produced mixed results. Using event-related functional magnetic resonance imaging, we reexamined this issue with a semantic categorization task that allowed for uniform semantic judgments of concrete and abstract words. The participants were 20 healthy adults. Functional analyses contrasted activation associated with concrete and abstract meanings of ambiguous and unambiguous words. Results showed that for both ambiguous and unambiguous words, abstract meanings were associated with more widespread cortical activation than concrete meanings in numerous regions associated with semantic processing, including temporal, parietal, and frontal cortices. These results are inconsistent with both dual-coding and context-availability theories, as these theories propose that the representations of abstract concepts are relatively impoverished. Our results suggest, instead, that semantic retrieval of abstract concepts involves a network of association areas. We argue that this finding is compatible with a theory of semantic representation such as Barsalou's [Barsalou, L. W. Perceptual symbol systems. Behavioral & Brain Sciences, 22, 577-660, 1999] perceptual symbol systems, whereby concrete and abstract concepts are represented by similar mechanisms but with differences in focal content.

  12. Semantic guidance of eye movements in real-world scenes.

    Science.gov (United States)

    Hwang, Alex D; Wang, Hsueh-Cheng; Pomplun, Marc

    2011-05-25

    The perception of objects in our visual world is influenced by not only their low-level visual features such as shape and color, but also their high-level features such as meaning and semantic relations among them. While it has been shown that low-level features in real-world scenes guide eye movements during scene inspection and search, the influence of semantic similarity among scene objects on eye movements in such situations has not been investigated. Here we study guidance of eye movements by semantic similarity among objects during real-world scene inspection and search. By selecting scenes from the LabelMe object-annotated image database and applying latent semantic analysis (LSA) to the object labels, we generated semantic saliency maps of real-world scenes based on the semantic similarity of scene objects to the currently fixated object or the search target. An ROC analysis of these maps as predictors of subjects' gaze transitions between objects during scene inspection revealed a preference for transitions to objects that were semantically similar to the currently inspected one. Furthermore, during the course of a scene search, subjects' eye movements were progressively guided toward objects that were semantically similar to the search target. These findings demonstrate substantial semantic guidance of eye movements in real-world scenes and show its importance for understanding real-world attentional control. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. Emerging approaches in predictive toxicology.

    Science.gov (United States)

    Zhang, Luoping; McHale, Cliona M; Greene, Nigel; Snyder, Ronald D; Rich, Ivan N; Aardema, Marilyn J; Roy, Shambhu; Pfuhler, Stefan; Venkatactahalam, Sundaresan

    2014-12-01

    Predictive toxicology plays an important role in the assessment of toxicity of chemicals and the drug development process. While there are several well-established in vitro and in vivo assays that are suitable for predictive toxicology, recent advances in high-throughput analytical technologies and model systems are expected to have a major impact on the field of predictive toxicology. This commentary provides an overview of the state of the current science and a brief discussion on future perspectives for the field of predictive toxicology for human toxicity. Computational models for predictive toxicology, needs for further refinement and obstacles to expand computational models to include additional classes of chemical compounds are highlighted. Functional and comparative genomics approaches in predictive toxicology are discussed with an emphasis on successful utilization of recently developed model systems for high-throughput analysis. The advantages of three-dimensional model systems and stem cells and their use in predictive toxicology testing are also described. © 2014 Wiley Periodicals, Inc.

  14. Mass Spectrometry Applications for Toxicology.

    Science.gov (United States)

    Mbughuni, Michael M; Jannetto, Paul J; Langman, Loralie J

    2016-12-01

    Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used in the Toxicological analysis of drugs, poisons, and metabolites of both. To date, MS applications have permeated all fields of toxicology which include; environmental, clinical, and forensic toxicology. While many different analytical applications are used in these fields, MS and its hyphenated applications such as; gas chromatography MS (GC-MS), liquid chromatography MS (LC-MS), inductively coupled plasma ionization MS (ICP-MS), tandem mass spectrometry (MS/MS and MS n ) have emerged as powerful tools used in toxicology laboratories. This review will focus on these hyphenated MS technologies and their applications for toxicology.

  15. Mass Spectrometry Applications for Toxicology

    Science.gov (United States)

    Mbughuni, Michael M.; Jannetto, Paul J.

    2016-01-01

    Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used in the Toxicological analysis of drugs, poisons, and metabolites of both. To date, MS applications have permeated all fields of toxicology which include; environmental, clinical, and forensic toxicology. While many different analytical applications are used in these fields, MS and its hyphenated applications such as; gas chromatography MS (GC-MS), liquid chromatography MS (LC-MS), inductively coupled plasma ionization MS (ICP-MS), tandem mass spectrometry (MS/MS and MSn) have emerged as powerful tools used in toxicology laboratories. This review will focus on these hyphenated MS technologies and their applications for toxicology. PMID:28149262

  16. 164 Meaning and Thematic Roles in the Igbo Language Chukwuma ...

    African Journals Online (AJOL)

    Ike Odimegwu

    Chukwuma O. Okeke*. Abstract. Semantics is ... syntactic level of words, phrases, sentences, and even larger units of discourse ... Semantics has been defined as a level of linguistics which studies meaning. ..... English Language. New York: ...

  17. Concealed semantic and episodic autobiographical memory electrified.

    Science.gov (United States)

    Ganis, Giorgio; Schendan, Haline E

    2012-01-01

    Electrophysiology-based concealed information tests (CIT) try to determine whether somebody possesses concealed information about a crime-related item (probe) by comparing event-related potentials (ERPs) between this item and comparison items (irrelevants). Although the broader field is sometimes referred to as "memory detection," little attention has been paid to the precise type of underlying memory involved. This study begins addressing this issue by examining the key distinction between semantic and episodic memory in the autobiographical domain within a CIT paradigm. This study also addresses the issue of whether multiple repetitions of the items over the course of the session habituate the brain responses. Participants were tested in a 3-stimulus CIT with semantic autobiographical probes (their own date of birth) and episodic autobiographical probes (a secret date learned just before the study). Results dissociated these two memory conditions on several ERP components. Semantic probes elicited a smaller frontal N2 than episodic probes, consistent with the idea that the frontal N2 decreases with greater pre-existing knowledge about the item. Likewise, semantic probes elicited a smaller central N400 than episodic probes. Semantic probes also elicited a larger P3b than episodic probes because of their richer meaning. In contrast, episodic probes elicited a larger late positive complex (LPC) than semantic probes, because of the recent episodic memory associated with them. All these ERPs showed a difference between probes and irrelevants in both memory conditions, except for the N400, which showed a difference only in the semantic condition. Finally, although repetition affected the ERPs, it did not reduce the difference between probes and irrelevants. These findings show that the type of memory associated with a probe has both theoretical and practical importance for CIT research.

  18. Concealed semantic and episodic autobiographical memory electrified

    Science.gov (United States)

    Ganis, Giorgio; Schendan, Haline E.

    2013-01-01

    Electrophysiology-based concealed information tests (CIT) try to determine whether somebody possesses concealed information about a crime-related item (probe) by comparing event-related potentials (ERPs) between this item and comparison items (irrelevants). Although the broader field is sometimes referred to as “memory detection,” little attention has been paid to the precise type of underlying memory involved. This study begins addressing this issue by examining the key distinction between semantic and episodic memory in the autobiographical domain within a CIT paradigm. This study also addresses the issue of whether multiple repetitions of the items over the course of the session habituate the brain responses. Participants were tested in a 3-stimulus CIT with semantic autobiographical probes (their own date of birth) and episodic autobiographical probes (a secret date learned just before the study). Results dissociated these two memory conditions on several ERP components. Semantic probes elicited a smaller frontal N2 than episodic probes, consistent with the idea that the frontal N2 decreases with greater pre-existing knowledge about the item. Likewise, semantic probes elicited a smaller central N400 than episodic probes. Semantic probes also elicited a larger P3b than episodic probes because of their richer meaning. In contrast, episodic probes elicited a larger late positive complex (LPC) than semantic probes, because of the recent episodic memory associated with them. All these ERPs showed a difference between probes and irrelevants in both memory conditions, except for the N400, which showed a difference only in the semantic condition. Finally, although repetition affected the ERPs, it did not reduce the difference between probes and irrelevants. These findings show that the type of memory associated with a probe has both theoretical and practical importance for CIT research. PMID:23355816

  19. COMPUTATIONAL TOXICOLOGY-WHERE IS THE DATA? ...

    Science.gov (United States)

    This talk will briefly describe the state of the data world for computational toxicology and one approach to improve the situation, called ACToR (Aggregated Computational Toxicology Resource). This talk will briefly describe the state of the data world for computational toxicology and one approach to improve the situation, called ACToR (Aggregated Computational Toxicology Resource).

  20. Ninth Triennial Toxicology Salary Survey.

    Science.gov (United States)

    Gad, Shayne Cox; Sullivan, Dexter Wayne

    2016-01-01

    This survey serves as the ninth in a series of toxicology salary surveys conducted at 3-year intervals and beginning in 1988. An electronic survey instrument was distributed to 5919 individuals including members of the Society of Toxicology, American College of Toxicology, and 23 additional professional organizations. Question items inquired about gender, age, degree, years of experience, certifications held, areas of specialization, society membership, employment and income. Overall, 1293 responses were received (response rate 21.8%). The results of the 2014 survey provide insight into the job market and career path for current and future toxicologists. © The Author(s) 2016.

  1. Systems Toxicology: From Basic Research to Risk Assessment

    Science.gov (United States)

    2014-01-01

    Systems Toxicology is the integration of classical toxicology with quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Society demands increasingly close scrutiny of the potential health risks associated with exposure to chemicals present in our everyday life, leading to an increasing need for more predictive and accurate risk-assessment approaches. Developing such approaches requires a detailed mechanistic understanding of the ways in which xenobiotic substances perturb biological systems and lead to adverse outcomes. Thus, Systems Toxicology approaches offer modern strategies for gaining such mechanistic knowledge by combining advanced analytical and computational tools. Furthermore, Systems Toxicology is a means for the identification and application of biomarkers for improved safety assessments. In Systems Toxicology, quantitative systems-wide molecular changes in the context of an exposure are measured, and a causal chain of molecular events linking exposures with adverse outcomes (i.e., functional and apical end points) is deciphered. Mathematical models are then built to describe these processes in a quantitative manner. The integrated data analysis leads to the identification of how biological networks are perturbed by the exposure and enables the development of predictive mathematical models of toxicological processes. This perspective integrates current knowledge regarding bioanalytical approaches, computational analysis, and the potential for improved risk assessment. PMID:24446777

  2. Leveraging the Semantic Web for Adaptive Education

    Science.gov (United States)

    Kravcik, Milos; Gasevic, Dragan

    2007-01-01

    In the area of technology-enhanced learning reusability and interoperability issues essentially influence the productivity and efficiency of learning and authoring solutions. There are two basic approaches how to overcome these problems--one attempts to do it via standards and the other by means of the Semantic Web. In practice, these approaches…

  3. Validity Semantics in Educational and Psychological Assessment

    Science.gov (United States)

    Hathcoat, John D.

    2013-01-01

    The semantics, or meaning, of validity is a fluid concept in educational and psychological testing. Contemporary controversies surrounding this concept appear to stem from the proper location of validity. Under one view, validity is a property of score-based inferences and entailed uses of test scores. This view is challenged by the…

  4. Subtyping can have a simple semantics

    NARCIS (Netherlands)

    Balsters, H.; Fokkinga, M.M.

    1991-01-01

    Consider a first order typed language, with semantics $S$ for expressions and types. Adding subtyping means that a partial order $<$; on types is defined and that the typing rules are extended to the effect that expression $e$ has type $t$ whenever $e$ has type $s$ and $s

  5. 19 Additive and Substitutive Borrowing against Semantic ...

    African Journals Online (AJOL)

    reflexes mean 'to forge' and/or 'black-smith' (Ibid, 49). The Theory of Semantic Narrowing and Broadening in the. Realm of Lexical Borrowing ..... should be noticed that the traditional label referred to a hole on the whole of a traditional house ...

  6. Foundations of semantic web technologies

    CERN Document Server

    Hitzler, Pascal; Rudolph, Sebastian

    2009-01-01

    The Quest for Semantics Building Models Calculating with Knowledge Exchanging Information Semanic Web Technologies RESOURCE DESCRIPTION LANGUAGE (RDF)Simple Ontologies in RDF and RDF SchemaIntroduction to RDF Syntax for RDF Advanced Features Simple Ontologies in RDF Schema Encoding of Special Data Structures An ExampleRDF Formal Semantics Why Semantics? Model-Theoretic Semantics for RDF(S) Syntactic Reasoning with Deduction Rules The Semantic Limits of RDF(S)WEB ONTOLOGY LANGUAGE (OWL) Ontologies in OWL OWL Syntax and Intuitive Semantics OWL Species The Forthcoming OWL 2 StandardOWL Formal Sem

  7. Semantic Web and Model-Driven Engineering

    CERN Document Server

    Parreiras, Fernando S

    2012-01-01

    The next enterprise computing era will rely on the synergy between both technologies: semantic web and model-driven software development (MDSD). The semantic web organizes system knowledge in conceptual domains according to its meaning. It addresses various enterprise computing needs by identifying, abstracting and rationalizing commonalities, and checking for inconsistencies across system specifications. On the other side, model-driven software development is closing the gap among business requirements, designs and executables by using domain-specific languages with custom-built syntax and se

  8. Comparing Refinements for Failure and Bisimulation Semantics

    NARCIS (Netherlands)

    Eshuis, H.; Fokkinga, M.M.

    2002-01-01

    Refinement in bisimulation semantics is defined differently from refinement in failure semantics: in bisimulation semantics refinement is based on simulations between labelled transition systems, whereas in failure semantics refinement is based on inclusions between failure systems. There exist

  9. The autonomy of grammar and semantic internalism

    Directory of Open Access Journals (Sweden)

    Dobler Tamara

    2014-01-01

    Full Text Available In his post-Tractatus work on natural language use, Wittgenstein defended the notion of what he dubbed the autonomy of grammar. According to this thought, grammar - or semantics, in a more recent idiom - is essentially autonomous from metaphysical considerations, and is not answerable to the nature of things. The argument has several related incarnations in Wittgenstein’s post-Tractatus writings, and has given rise to a number of important insights, both critical and constructive. In this paper I will argue for a potential connection between Wittgenstein’s autonomy argument and some more recent internalist arguments for the autonomy of semantics. My main motivation for establishing this connection comes from the fact that the later Wittgenstein’s comments on grammar and meaning stand in opposition to some of the core assumptions of semantic externalism.

  10. American College of Medical Toxicology

    Science.gov (United States)

    ... Publications Journal of Medical Toxicology About ACMT About Us History of ACMT ACMT Fact Sheet Strategic Plan ACMT ... Policies IJMT JMT Editorial Board About ACMT About Us History of ACMT ACMT Fact Sheet Strategic Plan ACMT ...

  11. Aggregated Computational Toxicology Resource (ACTOR)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Aggregated Computational Toxicology Resource (ACTOR) is a database on environmental chemicals that is searchable by chemical name and other identifiers, and by...

  12. Predictive toxicology in drug safety

    National Research Council Canada - National Science Library

    Xu, Jinghai J; Urban, Laszlo

    2011-01-01

    .... It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment, and promotes evidence-based toxicology...

  13. Aggregated Computational Toxicology Online Resource

    Data.gov (United States)

    U.S. Environmental Protection Agency — Aggregated Computational Toxicology Online Resource (AcTOR) is EPA's online aggregator of all the public sources of chemical toxicity data. ACToR aggregates data...

  14. Toxicology of Biodiesel Combustion products

    Science.gov (United States)

    1. Introduction The toxicology of combusted biodiesel is an emerging field. Much of the current knowledge about biological responses and health effects stems from studies of exposures to other fuel sources (typically petroleum diesel, gasoline, and wood) incompletely combusted. ...

  15. Mass Spectrometry Applications for Toxicology

    OpenAIRE

    Mbughuni, Michael M.; Jannetto, Paul J.; Langman, Loralie J.

    2016-01-01

    Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used i...

  16. Behavioral assays in environmental toxicology

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, B.

    1979-01-01

    Environmental toxicology is too permeated by questions about how the whole organism functions to abandon intact animals as test systems. Behavior does not participate as a single entity or discipline. It ranges across the total spectrum of functional toxicity, from tenuous subjective complaints to subtle sensory and motor disturbances demanding advanced instrumentation for their evaluation. Three facets of behavioral toxicology that illustrate its breadth of interests and potential contributions are discussed.

  17. A practice analysis of toxicology.

    Science.gov (United States)

    Wood, Carol S; Weis, Christopher P; Caro, Carla M; Roe, Amy

    2016-12-01

    In 2015, the American Board of Toxicology (ABT), with collaboration from the Society of Toxicology (SOT), in consultation with Professional Examination Service, performed a practice analysis study of the knowledge required for general toxicology. The purpose of this study is to help assure that the examination and requirements for attainment of Diplomate status are relevant to modern toxicology and based upon an empirical foundation of knowledge. A profile of the domains and tasks used in toxicology practice was developed by subject-matter experts representing a broad range of experiences and perspectives. An on-line survey of toxicologists, including Diplomates of the ABT and SOT members, confirmed the delineation. Results of the study can be used to improve understanding of toxicology practice, to better serve all toxicologists, and to present the role of toxicologists to those outside the profession. Survey results may also be used by the ABT Board of Directors to develop test specifications for the certifying examination and will be useful for evaluating and updating the content of professional preparation, development, and continuing education programs. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Semantic Learning Service Personalized

    Directory of Open Access Journals (Sweden)

    Yibo Chen

    2012-02-01

    Full Text Available To provide users with more suitable and personalized service, personalization is widely used in various fields. Current e-Learning systems search for learning resources using information search technology, based on the keywords that selected or inputted by the user. Due to lack of semantic analysis for keywords and exploring the user contexts, the system cannot provide a good learning experiment. In this paper, we defined the concept and characteristic of the personalized learning service, and proposed a semantic learning service personalized framework. Moreover, we made full use of semantic technology, using ontologies to represent the learning contents and user profile, mining and utilizing the friendship and membership of the social relationship to construct the user social relationship profile, and improved the collaboration filtering algorithm to recommend personalized learning resources for users. The results of the empirical evaluation show that the approach is effectiveness in augmenting recommendation.

  19. Semantic Observation Integration

    Directory of Open Access Journals (Sweden)

    Werner Kuhn

    2012-09-01

    Full Text Available Although the integration of sensor-based information into analysis and decision making has been a research topic for many years, semantic interoperability has not yet been reached. The advent of user-generated content for the geospatial domain, Volunteered Geographic Information (VGI, makes it even more difficult to establish semantic integration. This paper proposes a novel approach to integrating conventional sensor information and VGI, which is exploited in the context of detecting forest fires. In contrast to common logic-based semantic descriptions, we present a formal system using algebraic specifications to unambiguously describe the processing steps from natural phenomena to value-added information. A generic ontology of observations is extended and profiled for forest fire detection in order to illustrate how the sensing process, and transformations between heterogeneous sensing systems, can be represented as mathematical functions and grouped into abstract data types. We discuss the required ontological commitments and a possible generalization.

  20. The Semantics of "Violence"

    DEFF Research Database (Denmark)

    Levisen, Carsten

    This paper presents a semantic analysis of “violence” – a word around which Anglo-internationaldiscourses revolve. Many ethnolinguistic communities around the world are currently adapting thisEnglish lexical concept into their linguistic systems, and, presumably also, the view of the worldembodied...... by the “violence” concept.Based on semantic fieldwork in Port Vila, the creolophone capital of Vanuatu in the SouthPacific, the paper investigates the discursive introduction of “violence” into a community which,until recently, lived by other concepts. I compare and contrast the traditional Bislama concepts...... kilimand faetem with the newly imported English word vaeolens (violence). My study provides newevidence for how cognitive and semantic change co-occur in the context of postcolonial linguisticcommunities, and my paper addresses an important, ongoing controversy related to the notion of“Anglocentric bias...

  1. Intuitions and Competence in Formal Semantics

    Directory of Open Access Journals (Sweden)

    Martin Stokhof

    2010-12-01

    Full Text Available In formal semantics intuition plays a key role, in two ways. Intuitions about semantic properties of expressions are the primary data, and intuitions of the semanticists are the main access to these data. The paper investigates how this dual role is related to the concept of competence and the role that this concept plays in semantics. And it inquires whether the self-reflexive role of intuitions has consequences for the methodology of semantics as an empirical discipline.ReferencesBaggio, Giosuè, van Lambalgen, Michiel & Hagoort, Peter. 2008. ‘Computing and recomputing discourse models: an ERP study of the semantics of temporal connectives’. Journal of Memory and Language 59, no. 1: 36–53.http://dx.doi.org/10.1016/j.jml.2008.02.005Chierchia, Gennaro & McConnell-Ginet, Sally. 2000. Meaning and Grammar. second ed. Cambridge, Mass.: MIT Press.Chomsky, Noam. 1965. Aspects of the Theory of Syntax. Cambridge, Mass.: MIT Press.Cresswell, Max J. 1978. ‘Semantic competence’. In F. Guenthner & M. Guenther-Reutter (eds. ‘Meaning and Translation’, 9–27. Duckworth, London. de Swart, Henriëtte. 1998. Introduction to Natural Language Semantics. Stanford: CSLI.Dowty, David, Wall, Robert & Peters, Stanley. 1981. Introduction to Montague Semantics. Dordrecht: Reidel.Heim, Irene & Kratzer, Angelika. 1998. Semantics in Generative Grammar. Oxford: Blackwell.Larson, Richard & Segal, Gabriel. 1995. Knowledge of Meaning. Cambridge, Mass.: MIT Press.Lewis, David K. 1975. ‘Languages and Language’. In Keith Gunderson (ed. ‘Language, Mind and Knowledge’, 3–35. Minneapolis: University of Minnesota Press.Montague, Richard. 1970. ‘Universal Grammar’. Theoria 36: 373–98.http://dx.doi.org/10.1111/j.1755-2567.1970.tb00434.xPartee, Barbara H. 1979. ‘Semantics – Mathematics or Psychology?’ In Rainer Bäuerle, Urs Egli & Arnim von Stechow (eds. ‘Semantics from Different Points of View’, 1–14. Berlin: Springer.Partee, Barbara H. 1980.

  2. The MMI Semantic Framework: Rosetta Stones for Earth Sciences

    Science.gov (United States)

    Rueda, C.; Bermudez, L. E.; Graybeal, J.; Alexander, P.

    2009-12-01

    Semantic interoperability—the exchange of meaning among computer systems—is needed to successfully share data in Ocean Science and across all Earth sciences. The best approach toward semantic interoperability requires a designed framework, and operationally tested tools and infrastructure within that framework. Currently available technologies make a scientific semantic framework feasible, but its development requires sustainable architectural vision and development processes. This presentation outlines the MMI Semantic Framework, including recent progress on it and its client applications. The MMI Semantic Framework consists of tools, infrastructure, and operational and community procedures and best practices, to meet short-term and long-term semantic interoperability goals. The design and prioritization of the semantic framework capabilities are based on real-world scenarios in Earth observation systems. We describe some key uses cases, as well as the associated requirements for building the overall infrastructure, which is realized through the MMI Ontology Registry and Repository. This system includes support for community creation and sharing of semantic content, ontology registration, version management, and seamless integration of user-friendly tools and application programming interfaces. The presentation describes the architectural components for semantic mediation, registry and repository for vocabularies, ontology, and term mappings. We show how the technologies and approaches in the framework can address community needs for managing and exchanging semantic information. We will demonstrate how different types of users and client applications exploit the tools and services for data aggregation, visualization, archiving, and integration. Specific examples from OOSTethys (http://www.oostethys.org) and the Ocean Observatories Initiative Cyberinfrastructure (http://www.oceanobservatories.org) will be cited. Finally, we show how semantic augmentation of web

  3. Combining semantics with non-standard interpreter hierarchies

    DEFF Research Database (Denmark)

    Abramov, Sergei M.; Glück, Robert

    2000-01-01

    This paper reports on results concerning the combination of non-standard semantics via interpreters. We define what a semantics combination means and identify under which conditions a combination can be realized by computer programs (robustness, safely combinable). We develop the underlying mathe...... mathematical theory and examine the meaning of several non-standard interpreter towers. Our results suggest a technique for the implementation of a certain class of programming language dialects by composing a hierarchy of non-standard interpreters....

  4. Ontology based heterogeneous materials database integration and semantic query

    Science.gov (United States)

    Zhao, Shuai; Qian, Quan

    2017-10-01

    Materials digital data, high throughput experiments and high throughput computations are regarded as three key pillars of materials genome initiatives. With the fast growth of materials data, the integration and sharing of data is very urgent, that has gradually become a hot topic of materials informatics. Due to the lack of semantic description, it is difficult to integrate data deeply in semantic level when adopting the conventional heterogeneous database integration approaches such as federal database or data warehouse. In this paper, a semantic integration method is proposed to create the semantic ontology by extracting the database schema semi-automatically. Other heterogeneous databases are integrated to the ontology by means of relational algebra and the rooted graph. Based on integrated ontology, semantic query can be done using SPARQL. During the experiments, two world famous First Principle Computational databases, OQMD and Materials Project are used as the integration targets, which show the availability and effectiveness of our method.

  5. Semi-Supervised Learning to Identify UMLS Semantic Relations.

    Science.gov (United States)

    Luo, Yuan; Uzuner, Ozlem

    2014-01-01

    The UMLS Semantic Network is constructed by experts and requires periodic expert review to update. We propose and implement a semi-supervised approach for automatically identifying UMLS semantic relations from narrative text in PubMed. Our method analyzes biomedical narrative text to collect semantic entity pairs, and extracts multiple semantic, syntactic and orthographic features for the collected pairs. We experiment with seeded k-means clustering with various distance metrics. We create and annotate a ground truth corpus according to the top two levels of the UMLS semantic relation hierarchy. We evaluate our system on this corpus and characterize the learning curves of different clustering configuration. Using KL divergence consistently performs the best on the held-out test data. With full seeding, we obtain macro-averaged F-measures above 70% for clustering the top level UMLS relations (2-way), and above 50% for clustering the second level relations (7-way).

  6. Semantic Versus Syntactic Cutting Planes

    OpenAIRE

    Filmus, Yuval; Hrubeš, Pavel; Lauria, Massimo

    2016-01-01

    In this paper, we compare the strength of the semantic and syntactic version of the cutting planes proof system. First, we show that the lower bound technique of Pudlák applies also to semantic cutting planes: the proof system has feasible interpolation via monotone real circuits, which gives an exponential lower bound on lengths of semantic cutting planes refutations. Second, we show that semantic refutations are stronger than syntactic ones. In particular, we give a formula for whic...

  7. Flow Logics and Operational Semantics

    DEFF Research Database (Denmark)

    Nielson, Flemming; Nielson, Hanne Riis

    1998-01-01

    Flow logic is a “fast prototyping” approach to program analysis that shows great promise of being able to deal with a wide variety of languages and calculi for computation. However, seemingly innocent choices in the flow logic as well as in the operational semantics may inhibit proving the analys...... correct. Our main conclusion is that environment based semantics is more flexible than either substitution based semantics or semantics making use of structural congruences (like alpha-renaming)....

  8. Ethanol Forensic Toxicology.

    Science.gov (United States)

    Perry, Paul J; Doroudgar, Shadi; Van Dyke, Priscilla

    2017-12-01

    Ethanol abuse can lead to negative consequences that oftentimes result in criminal charges and civil lawsuits. When an individual is suspected of driving under the influence, law enforcement agents can determine the extent of intoxication by measuring the blood alcohol concentration (BAC) and performing a standardized field sobriety test. The BAC is dependent on rates of absorption, distribution, and elimination, which are influenced mostly by the dose of ethanol ingested and rate of consumption. Other factors contributing to BAC are gender, body mass and composition, food effects, type of alcohol, and chronic alcohol exposure. Because of individual variability in ethanol pharmacology and toxicology, careful extrapolation and interpretation of the BAC is needed, to justify an arrest and assignment of criminal liability. This review provides a summary of the pharmacokinetic properties of ethanol and the clinical effects of acute intoxication as they relate to common forensic questions. Concerns regarding the extrapolation of BAC and the implications of impaired memory caused by alcohol-induced blackouts are discussed. © 2017 American Academy of Psychiatry and the Law.

  9. [Toxicologic blood emergency screening].

    Science.gov (United States)

    Cohen, Sabine; Manat, Aurélie; Dumont, Benoit; Bévalot, Fabien; Manchon, Monique; Berny, Claudette

    2010-01-01

    In order to overcome the stop marketing by Biorad company of automated high performance liquid chromatograph with UV detection (Remedi), we developed a gas chromatography-mass spectrometry (GC-MS) to detect and to give an approximation of the overdose of molecules frequently encountered in drug intoxications. Therefore two hundred eighty seventeen blood samples were collected over a period of one year and allowed us to evaluate and compare the performance of these two techniques. As identification, GC-MS does not identify all molecules detected by Remedi in 24.2% of cases; there is a lack of sensitivity for opiates and the systematic absence of certain molecules such as betablockers. However, in 75.8% of cases the GC-MS detects all molecules found by Remedi and other molecules such as meprobamate, paracetamol, benzodiazepines and phenobarbital. The concentrations obtained are interpreted in terms of overdose showed 15.7% of discrepancy and 84.3% of concordance between the two techniques. The GC-MS technique described here is robust, fast and relatively simple to implement; the identification is facilitated by macro commands and the semi quantification remains manual. Despite a sequence of cleaning the column after each sample, carryover of a sample to the next remains possible. This technique can be used for toxicologic screening in acute intoxications. Nevertheless it must be supplemented by a HPLC with UV detection if molecules such as betablockers are suspected.

  10. Toxicology of plutonium

    International Nuclear Information System (INIS)

    Bair, W.J.

    1974-01-01

    Data are reviewed from studies on the toxicity of Pu in experimental animals. Of the several plutonium isotopes, only 238 Pu and 239 Pu have been studied well. Sufficient results have been obtained to show that the behavior of 238 Pu in biological systems and the resulting biological effects cannot be precisely predicted from studies of 239 Pu. This probably applies also to other radiologically important plutonium isotopes which have half-lives ranging from 45 days to 10 7 years and decay by β-emission, electron capture, and spontaneous fission, as well as by emission of α-particles. All the biological effects of plutonium described in this review are attributed to alpha-particle radiation emitted by the plutonium. However, since plutonium is a chemically active heavy metal, one cannot ignore the possibility of chemical toxicity of the low-specific-activity isotopes, 239 Pu, 242 Pu, and 244 Pu. The preponderance of our knowledge of plutonium toxicology has come from short-term studies of relatively high dosage levels in several animal species. The consequences of high-level internal exposures can be predicted with confidence in experimental animals and probably also in man. However, considering the care with which plutonium is handled in the nuclear industry, a high-level contamination event is unlikely. Considerably less is known about the long-term effects of low levels of contamination. (250 references) (U.S.)

  11. Semantic Search of Web Services

    Science.gov (United States)

    Hao, Ke

    2013-01-01

    This dissertation addresses semantic search of Web services using natural language processing. We first survey various existing approaches, focusing on the fact that the expensive costs of current semantic annotation frameworks result in limited use of semantic search for large scale applications. We then propose a vector space model based service…

  12. Semantic memory in object use.

    Science.gov (United States)

    Silveri, Maria Caterina; Ciccarelli, Nicoletta

    2009-10-01

    We studied five patients with semantic memory disorders, four with semantic dementia and one with herpes simplex virus encephalitis, to investigate the involvement of semantic conceptual knowledge in object use. Comparisons between patients who had semantic deficits of different severity, as well as the follow-up, showed that the ability to use objects was largely preserved when the deficit was mild but progressively decayed as the deficit became more severe. Naming was generally more impaired than object use. Production tasks (pantomime execution and actual object use) and comprehension tasks (pantomime recognition and action recognition) as well as functional knowledge about objects were impaired when the semantic deficit was severe. Semantic and unrelated errors were produced during object use, but actions were always fluent and patients performed normally on a novel tools task in which the semantic demand was minimal. Patients with severe semantic deficits scored borderline on ideational apraxia tasks. Our data indicate that functional semantic knowledge is crucial for using objects in a conventional way and suggest that non-semantic factors, mainly non-declarative components of memory, might compensate to some extent for semantic disorders and guarantee some residual ability to use very common objects independently of semantic knowledge.

  13. Perceptual-Semantic Congruency Facilitates Semantic Discrimination of Thermal Qualities

    Directory of Open Access Journals (Sweden)

    Yizhen Zhou

    2017-12-01

    Full Text Available The ability to sense temperature is vital to our life. It signals the environmental condition, reflects the physiological conditions of our own body, and generates feelings of pleasantness or unpleasantness. Moreover, recent studies have demonstrated implicit associations between physical temperature and social/emotional concepts, suggesting the processing of temperature may even influence cognition. In this work, we examined the effect of physical warmth and coldness on semantic cognition. Participants performed speeded target categorization for thermal descriptors in the form of semantic words or illustrative figures representing the thermal qualities “warm” or “cold” while physical thermal stimulation was presented. We compared the average reaction time (RT for the congruent and incongruent conditions managed by response key assignments. In the congruent condition, the response key for the symbol associated with warmth (coldness was assigned to the hand with warm (cold thermal stimulation, and in the incongruent condition the key assignment was reversed. Our results demonstrate that the average RT in the congruent condition was faster than in the incongruent one for both forms of thermal descriptors, suggesting that the experience of physical temperature facilitates the internal processing of the meaning of thermal quality.

  14. In silico toxicology for the pharmaceutical sciences

    International Nuclear Information System (INIS)

    Valerio, Luis G.

    2009-01-01

    The applied use of in silico technologies (a.k.a. computational toxicology, in silico toxicology, computer-assisted tox, e-tox, i-drug discovery, predictive ADME, etc.) for predicting preclinical toxicological endpoints, clinical adverse effects, and metabolism of pharmaceutical substances has become of high interest to the scientific community and the public. The increased accessibility of these technologies for scientists and recent regulations permitting their use for chemical risk assessment supports this notion. The scientific community is interested in the appropriate use of such technologies as a tool to enhance product development and safety of pharmaceuticals and other xenobiotics, while ensuring the reliability and accuracy of in silico approaches for the toxicological and pharmacological sciences. For pharmaceutical substances, this means active and impurity chemicals in the drug product may be screened using specialized software and databases designed to cover these substances through a chemical structure-based screening process and algorithm specific to a given software program. A major goal for use of these software programs is to enable industry scientists not only to enhance the discovery process but also to ensure the judicious use of in silico tools to support risk assessments of drug-induced toxicities and in safety evaluations. However, a great amount of applied research is still needed, and there are many limitations with these approaches which are described in this review. Currently, there is a wide range of endpoints available from predictive quantitative structure-activity relationship models driven by many different computational software programs and data sources, and this is only expected to grow. For example, there are models based on non-proprietary and/or proprietary information specific to assessing potential rodent carcinogenicity, in silico screens for ICH genetic toxicity assays, reproductive and developmental toxicity, theoretical

  15. Semantator: annotating clinical narratives with semantic web ontologies.

    Science.gov (United States)

    Song, Dezhao; Chute, Christopher G; Tao, Cui

    2012-01-01

    To facilitate clinical research, clinical data needs to be stored in a machine processable and understandable way. Manual annotating clinical data is time consuming. Automatic approaches (e.g., Natural Language Processing systems) have been adopted to convert such data into structured formats; however, the quality of such automatically extracted data may not always be satisfying. In this paper, we propose Semantator, a semi-automatic tool for document annotation with Semantic Web ontologies. With a loaded free text document and an ontology, Semantator supports the creation/deletion of ontology instances for any document fragment, linking/disconnecting instances with the properties in the ontology, and also enables automatic annotation by connecting to the NCBO annotator and cTAKES. By representing annotations in Semantic Web standards, Semantator supports reasoning based upon the underlying semantics of the owl:disjointWith and owl:equivalentClass predicates. We present discussions based on user experiences of using Semantator.

  16. Semantic Barbs and Biorthogonality

    OpenAIRE

    Rathke, J.; Sassone, V.; Sobocinski, P.

    2007-01-01

    We use the framework of biorthogonality to introduce a novel semantic definition of the concept of barb (basic observable) for process calculi. We develop a uniform basic theory of barbs and demonstrate its robustness by showing that it gives rise to the correct observables in specific process calculi which model synchronous, asynchronous and broadcast communication regimes.

  17. Semantic data bank

    International Nuclear Information System (INIS)

    Anoreewsky, Evelyne; Nicolas, P.; Grillo, J.P.

    1977-01-01

    A system is proposed for determining semantic relations between lexical items. To do this, a descriptor is associated with each lexical item; two types of algorithms are used to calculate the relationships between descriptors ('similarity' or 'predicativity' relations). This system makes it possible to simulate linguistic experiences. Some results have been predicted and verified experimentally. [fr

  18. The semantic similarity ensemble

    Directory of Open Access Journals (Sweden)

    Andrea Ballatore

    2013-12-01

    Full Text Available Computational measures of semantic similarity between geographic terms provide valuable support across geographic information retrieval, data mining, and information integration. To date, a wide variety of approaches to geo-semantic similarity have been devised. A judgment of similarity is not intrinsically right or wrong, but obtains a certain degree of cognitive plausibility, depending on how closely it mimics human behavior. Thus selecting the most appropriate measure for a specific task is a significant challenge. To address this issue, we make an analogy between computational similarity measures and soliciting domain expert opinions, which incorporate a subjective set of beliefs, perceptions, hypotheses, and epistemic biases. Following this analogy, we define the semantic similarity ensemble (SSE as a composition of different similarity measures, acting as a panel of experts having to reach a decision on the semantic similarity of a set of geographic terms. The approach is evaluated in comparison to human judgments, and results indicate that an SSE performs better than the average of its parts. Although the best member tends to outperform the ensemble, all ensembles outperform the average performance of each ensemble's member. Hence, in contexts where the best measure is unknown, the ensemble provides a more cognitively plausible approach.

  19. Learning semantic query suggestions

    NARCIS (Netherlands)

    Meij, E.; Bron, M.; Hollink, L.; Huurnink, B.; de Rijke, M.

    2009-01-01

    An important application of semantic web technology is recognizing human-defined concepts in text. Query transformation is a strategy often used in search engines to derive queries that are able to return more useful search results than the original query and most popular search engines provide

  20. Levels of Literary Meaning

    DEFF Research Database (Denmark)

    Klausen, Søren Harnow

    2017-01-01

    I argue that intentionalist theories of meaning and interpretation, like those of Hirsch and Juhl, have been insufficiently attentive to the different levels of authorial intention that are operative in literary works. By countenancing intentions on different levels – ranging from simple semantic...

  1. Semantic Neighborhood Effects for Abstract versus Concrete Words.

    Science.gov (United States)

    Danguecan, Ashley N; Buchanan, Lori

    2016-01-01

    Studies show that semantic effects may be task-specific, and thus, that semantic representations are flexible and dynamic. Such findings are critical to the development of a comprehensive theory of semantic processing in visual word recognition, which should arguably account for how semantic effects may vary by task. It has been suggested that semantic effects are more directly examined using tasks that explicitly require meaning processing relative to those for which meaning processing is not necessary (e.g., lexical decision task). The purpose of the present study was to chart the processing of concrete versus abstract words in the context of a global co-occurrence variable, semantic neighborhood density (SND), by comparing word recognition response times (RTs) across four tasks varying in explicit semantic demands: standard lexical decision task (with non-pronounceable non-words), go/no-go lexical decision task (with pronounceable non-words), progressive demasking task, and sentence relatedness task. The same experimental stimulus set was used across experiments and consisted of 44 concrete and 44 abstract words, with half of these being low SND, and half being high SND. In this way, concreteness and SND were manipulated in a factorial design using a number of visual word recognition tasks. A consistent RT pattern emerged across tasks, in which SND effects were found for abstract (but not necessarily concrete) words. Ultimately, these findings highlight the importance of studying interactive effects in word recognition, and suggest that linguistic associative information is particularly important for abstract words.

  2. Focus on Meaning

    DEFF Research Database (Denmark)

    Zhang, Chun; Wang Jingjing, Jenny

    recognizing new vocabulary (two-, three and four-character words) in a series of simple meaning recognition tests administered by the authors over three weeks. The test sets consist of vocabulary with target words that were given semantic and conceptual explanation by the authors in the previous week......Abstract This study examines the effect of mapping between the semantic and conceptual representation of target words 房,堂,屋, and 厅on Chinese (L2) vocabulary learning at a university class. Students (N=25) were the 2nd-year Chinese –major students at one university in Denmark. They were given tests...... of Chinese (L2) words can have a measurable effect on students’ efficacy of (Nation 2011) vocabulary learning in the classroom. The findings also reveal that conceptual representation of Chinese (L2) words reinforce the students’ reliance on L 1 by building a link between L 1semantic representations and L 2...

  3. Manpower Development in Toxicology. EURO Reports and Studies, No. 9.

    Science.gov (United States)

    World Health Organization, Copenhagen (Denmark). Regional Office for Europe.

    This report addresses the widely held view that currently available literature in toxicology is inadequate in that there is a need to identify manpower deficiencies in this field and to suggest means to correct these deficiencies. It contains a list of specific recommendations including the organization of a working group, sponsored by the World…

  4. In Silico Toxicology – Non-Testing Methods

    Science.gov (United States)

    Raunio, Hannu

    2011-01-01

    In silico toxicology in its broadest sense means “anything that we can do with a computer in toxicology.” Many different types of in silico methods have been developed to characterize and predict toxic outcomes in humans and environment. The term non-testing methods denote grouping approaches, structure–activity relationship, and expert systems. These methods are already used for regulatory purposes and it is anticipated that their role will be much more prominent in the near future. This Perspective will delineate the basic principles of non-testing methods and evaluate their role in current and future risk assessment of chemical compounds. PMID:21772821

  5. Exploring and linking biomedical resources through multidimensional semantic spaces.

    Science.gov (United States)

    Berlanga, Rafael; Jiménez-Ruiz, Ernesto; Nebot, Victoria

    2012-01-25

    The semantic integration of biomedical resources is still a challenging issue which is required for effective information processing and data analysis. The availability of comprehensive knowledge resources such as biomedical ontologies and integrated thesauri greatly facilitates this integration effort by means of semantic annotation, which allows disparate data formats and contents to be expressed under a common semantic space. In this paper, we propose a multidimensional representation for such a semantic space, where dimensions regard the different perspectives in biomedical research (e.g., population, disease, anatomy and protein/genes). This paper presents a novel method for building multidimensional semantic spaces from semantically annotated biomedical data collections. This method consists of two main processes: knowledge and data normalization. The former one arranges the concepts provided by a reference knowledge resource (e.g., biomedical ontologies and thesauri) into a set of hierarchical dimensions for analysis purposes. The latter one reduces the annotation set associated to each collection item into a set of points of the multidimensional space. Additionally, we have developed a visual tool, called 3D-Browser, which implements OLAP-like operators over the generated multidimensional space. The method and the tool have been tested and evaluated in the context of the Health-e-Child (HeC) project. Automatic semantic annotation was applied to tag three collections of abstracts taken from PubMed, one for each target disease of the project, the Uniprot database, and the HeC patient record database. We adopted the UMLS Meta-thesaurus 2010AA as the reference knowledge resource. Current knowledge resources and semantic-aware technology make possible the integration of biomedical resources. Such an integration is performed through semantic annotation of the intended biomedical data resources. This paper shows how these annotations can be exploited for

  6. Toxicological aspects of energy production

    International Nuclear Information System (INIS)

    Sanders, C.L.

    1986-01-01

    Part I reviews the principles of toxicology, describes the biological fate of chemicals in the body, discusses basic pathobiology, and reviews short-term toxicity tests. Part II describes the toxicology and pathology of pollutants in several important organ systems. The greatest emphasis is placed on the respiratory tract because of its high probability as a route of exposure to pollutants from energy technologies and its high sensitivity to pollutant related tissue damage. Part III describes the toxicological aspects of specific chemical classes associated with fossil fuels; these include polycyclic hydrocarbons, gases and metals. Part IV describes the biomedical effects associated with each energy technology, including coal and oil, fossil fuel and biomass conversions, solar and geothermal and radiological health aspects associated with uranium mining, nuclear fission and fusion, and with nonionising radiations and electromagnetic fields

  7. 2007 TOXICOLOGY AND RISK ASSESSMENT ...

    Science.gov (United States)

    EPA has announced The 2007 Toxicology and Risk Assessment Conference Cincinnati Marriott North, West Chester (Cincinnati), OHApril 23- 26, 2007 - Click to register!The Annual Toxicology and Risk Assessment Conference is a unique meeting where several Government Agencies come together to discuss toxicology and risk assessment issues that are not only of concern to the government, but also to a broader audience including academia and industry. The theme of this year's conference is Emerging Issues and Challenges in Risk Assessment and the preliminary agenda includes: Plenary Sessions and prominent speakers (tentative) include: Issues of Emerging Chemical ContaminantsUncertainty and Variability in Risk Assessment Use of Mechanistic data in IARC evaluationsParallel Sessions:Uncertainty and Variability in Dose-Response Assessment Recent Advances in Toxicity and Risk Assessment of RDX The Use of Epidemiologic Data for Risk Assessment Applications Cumulative Health Risk Assessment:

  8. Semantics of the VDM Real-Time Dialect

    DEFF Research Database (Denmark)

    Lausdahl, Kenneth; Coleman, Joey; Larsen, Peter Gorm

    All formally defined languages need to be given an unambiguous semantics such that the meaning of all models expressed using the language is clear. In this technical report a semantic model is provided for the Real-Time dialect of the Vienna Development Method (VDM). This builds upon both...... the formal semantics provided for the ISO standard VDM Specification Language, and on other work on the core of the VDM-RT notation. Although none of the VDM dialects are executable in general, the primary focus of the work presented here is on the executable subset. This focus is result of parallel work...

  9. Data Cleaning and Semantic Improvement in Biological Databases

    Directory of Open Access Journals (Sweden)

    Apiletti Daniele

    2006-12-01

    Full Text Available Public genomic and proteomic databases can be affected by a variety of errors. These errors may involve either the description or the meaning of data (namely, syntactic or semantic errors. We focus our analysis on the detection of semantic errors, in order to verify the accuracy of the stored information. In particular, we address the issue of data constraints and functional dependencies among attributes in a given relational database. Constraints and dependencies show semantics among attributes in a database schema and their knowledge may be exploited to improve data quality and integration in database design, and to perform query optimization and dimensional reduction.

  10. Developmental and Reproductive Toxicology Database (DART)

    Data.gov (United States)

    U.S. Department of Health & Human Services — A bibliographic database on the National Library of Medicine's (NLM) Toxicology Data Network (TOXNET) with references to developmental and reproductive toxicology...

  11. IRIS Toxicological Review of Acrolein (2003 Final)

    Science.gov (United States)

    EPA announced the release of the final report, Toxicological Review of Acrolein: in support of the Integrated Risk Information System (IRIS). The updated Summary for Acrolein and accompanying toxicological review have been added to the IRIS Database.

  12. 2nd International Conference on Proof-Theoretic Semantics

    CERN Document Server

    Schroeder-Heister, Peter

    2016-01-01

    This volume is the first ever collection devoted to the field of proof-theoretic semantics. Contributions address topics including the systematics of introduction and elimination rules and proofs of normalization, the categorial characterization of deductions, the relation between Heyting's and Gentzen's approaches to meaning, knowability paradoxes, proof-theoretic foundations of set theory, Dummett's justification of logical laws, Kreisel's theory of constructions, paradoxical reasoning, and the defence of model theory. The field of proof-theoretic semantics has existed for almost 50 years, but the term itself was proposed by Schroeder-Heister in the 1980s. Proof-theoretic semantics explains the meaning of linguistic expressions in general and of logical constants in particular in terms of the notion of proof. This volume emerges from presentations at the Second International Conference on Proof-Theoretic Semantics in Tübingen in 2013, where contributing authors were asked to provide a self-contained descri...

  13. Generation of Signs within Semantic and Phonological Categories: Data from Deaf Adults and Children Who Use American Sign Language

    Science.gov (United States)

    Beal-Alvarez, Jennifer S.; Figueroa, Daileen M.

    2017-01-01

    Two key areas of language development include semantic and phonological knowledge. Semantic knowledge relates to word and concept knowledge. Phonological knowledge relates to how language parameters combine to create meaning. We investigated signing deaf adults' and children's semantic and phonological sign generation via one-minute tasks,…

  14. From Data to Semantic Information

    Directory of Open Access Journals (Sweden)

    Luciano Floridi

    2003-06-01

    Full Text Available Abstract: There is no consensus yet on the definition of semantic information. This paper contributes to the current debate by criticising and revising the Standard Definition of semantic Information (SDI as meaningful data, in favour of the Dretske-Grice approach: meaningful and well-formed data constitute semantic information only if they also qualify as contingently truthful. After a brief introduction, SDI is criticised for providing necessary but insufficient conditions for the definition of semantic information. SDI is incorrect because truth-values do not supervene on semantic information, and misinformation (that is, false semantic information is not a type of semantic information, but pseudo-information, that is not semantic information at all. This is shown by arguing that none of the reasons for interpreting misinformation as a type of semantic information is convincing, whilst there are compelling reasons to treat it as pseudo-information. As a consequence, SDI is revised to include a necessary truth-condition. The last section summarises the main results of the paper and indicates the important implications of the revised definition for the analysis of the deflationary theories of truth, the standard definition of knowledge and the classic, quantitative theory of semantic information.

  15. Semantics of color in chromatism

    Science.gov (United States)

    Serov, Nikolai V.

    2002-06-01

    The aim of this investigation is to describe the semantics of color in chromatism (from the ancient Greek triune notion of >: (1) color as ideal (Id- plan), psychic; (2) tint as physical, verbal; material (M- plan), physiological, syntonic (S-plan), and (3) emotion as their informative-energetic correlation). Being a new field of science, chromatism links humanitarian and natural subjects by means of interdiscipline investigation of a real (f-m) man living in a real (color) surrounding environment. According to the definition for >, color may be considered to be the most universal notion, permitting to assume the unity of both a man and an environment. Due to this assumption, we may give models of human intellect.

  16. The role of the left anterior temporal lobe in semantic composition vs. semantic memory.

    Science.gov (United States)

    Westerlund, Masha; Pylkkänen, Liina

    2014-05-01

    The left anterior temporal lobe (LATL) is robustly implicated in semantic processing by a growing body of literature. However, these results have emerged from two distinct bodies of work, addressing two different processing levels. On the one hand, the LATL has been characterized as a 'semantic hub׳ that binds features of concepts across a distributed network, based on results from semantic dementia and hemodynamic findings on the categorization of specific compared to basic exemplars. On the other, the LATL has been implicated in combinatorial operations in language, as shown by increased activity in this region associated with the processing of sentences and of basic phrases. The present work aimed to reconcile these two literatures by independently manipulating combination and concept specificity within a minimal MEG paradigm. Participants viewed simple nouns that denoted either low specificity (fish) or high specificity categories (trout) presented in either combinatorial (spotted fish/trout) or non-combinatorial contexts (xhsl fish/trout). By combining these paradigms from the two literatures, we directly compared the engagement of the LATL in semantic memory vs. semantic composition. Our results indicate that although noun specificity subtly modulates the LATL activity elicited by single nouns, it most robustly affects the size of the composition effect when these nouns are adjectivally modified, with low specificity nouns eliciting a much larger effect. We conclude that these findings are compatible with an account in which the specificity and composition effects arise from a shared mechanism of meaning specification. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. Incidental Vocabulary Learning: A Semantic Field Approach

    Directory of Open Access Journals (Sweden)

    Parvaneh Khosravizadeh

    2011-10-01

    Full Text Available

    This study is an attempt to explore the difference between acquiring new words with different semantic fields to which they belong. In other words, the purpose of this study is to scrutinize the contribution of semantic field theory in learning new vocabulary items in an EFL setting. Thirty-eight students of three different levels of education took part in this research. They were exposed to some new words from four different semantic fields, and then they were tested on their acquisition of the words meaning. This exposure was through reading texts and the aim of reading was just comprehension, therefore the words were acquired incidentally. The outcome showed significant differences between groups with different levels of education regarding retention of words from different semantic fields.

  18. Bridging the semantic gap in sports

    Science.gov (United States)

    Li, Baoxin; Errico, James; Pan, Hao; Sezan, M. Ibrahim

    2003-01-01

    One of the major challenges facing current media management systems and the related applications is the so-called "semantic gap" between the rich meaning that a user desires and the shallowness of the content descriptions that are automatically extracted from the media. In this paper, we address the problem of bridging this gap in the sports domain. We propose a general framework for indexing and summarizing sports broadcast programs. The framework is based on a high-level model of sports broadcast video using the concept of an event, defined according to domain-specific knowledge for different types of sports. Within this general framework, we develop automatic event detection algorithms that are based on automatic analysis of the visual and aural signals in the media. We have successfully applied the event detection algorithms to different types of sports including American football, baseball, Japanese sumo wrestling, and soccer. Event modeling and detection contribute to the reduction of the semantic gap by providing rudimentary semantic information obtained through media analysis. We further propose a novel approach, which makes use of independently generated rich textual metadata, to fill the gap completely through synchronization of the information-laden textual data with the basic event segments. An MPEG-7 compliant prototype browsing system has been implemented to demonstrate semantic retrieval and summarization of sports video.

  19. Auto-Generated Semantic Processing Services

    Science.gov (United States)

    Davis, Rodney; Hupf, Greg

    2009-01-01

    Auto-Generated Semantic Processing (AGSP) Services is a suite of software tools for automated generation of other computer programs, denoted cross-platform semantic adapters, that support interoperability of computer-based communication systems that utilize a variety of both new and legacy communication software running in a variety of operating- system/computer-hardware combinations. AGSP has numerous potential uses in military, space-exploration, and other government applications as well as in commercial telecommunications. The cross-platform semantic adapters take advantage of common features of computer- based communication systems to enforce semantics, messaging protocols, and standards of processing of streams of binary data to ensure integrity of data and consistency of meaning among interoperating systems. The auto-generation aspect of AGSP Services reduces development time and effort by emphasizing specification and minimizing implementation: In effect, the design, building, and debugging of software for effecting conversions among complex communication protocols, custom device mappings, and unique data-manipulation algorithms is replaced with metadata specifications that map to an abstract platform-independent communications model. AGSP Services is modular and has been shown to be easily integrable into new and legacy NASA flight and ground communication systems.

  20. [Study on the change of semantic perspective of schistosomiasis control in China].

    Science.gov (United States)

    Zhou, Li-ying; Liu, Si-yuan; Li, Yu-ye; Deng, Yao; Yang, Kun

    2015-12-01

    To analyze the evolution process, discourse and semantic meaning of schistosomiasis prevention and control, so as to provide suggestions for control work. The official documents and mainstream media reports of schistosomiasis prevention and control were selected at different periods as discourse samples, and the deep social reasons behind the strategy change and the semantic meaning of the utterance were analyzed at different periods. The discourse of schistosomiasis prevention and control experienced the evolution of the political discourse, pluralistic discourse and public discourse, and the semantic connotations showed the authority conflict semantic features, and then transferred to semantic cooperation. The prevention and control of schistosomiasis have different semantic meanings at different periods, and the prevention and control work should correspond to a social practice, seek truth from facts, correctly understand the actual situation, and then establish the effective control policy.

  1. 42 CFR 493.937 - Toxicology.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Toxicology. 493.937 Section 493.937 Public Health... Proficiency Testing Programs by Specialty and Subspecialty § 493.937 Toxicology. (a) Program content and frequency of challenge. To be approved for proficiency testing for toxicology, the annual program must...

  2. 42 CFR 493.1213 - Condition: Toxicology.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Toxicology. 493.1213 Section 493.1213 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES....1213 Condition: Toxicology. If the laboratory provides services in the subspecialty of Toxicology, the...

  3. Life, Information, Entropy, and Time: Vehicles for Semantic Inheritance

    OpenAIRE

    Crofts, Antony R.

    2007-01-01

    Attempts to understand how information content can be included in an accounting of the energy flux of the biosphere have led to the conclusion that, in information transmission, one component, the semantic content, or “the meaning of the message,” adds no thermodynamic burden over and above costs arising from coding, transmission and translation. In biology, semantic content has two major roles. For all life forms, the message of the genotype encoded in DNA specifies the phenotype, and hence ...

  4. Semantic Activity Recognition

    OpenAIRE

    Thonnat , Monique

    2008-01-01

    International audience; Extracting automatically the semantics from visual data is a real challenge. We describe in this paper how recent work in cognitive vision leads to significative results in activity recognition for visualsurveillance and video monitoring. In particular we present work performed in the domain of video understanding in our PULSAR team at INRIA in Sophia Antipolis. Our main objective is to analyse in real-time video streams captured by static video cameras and to recogniz...

  5. [Toxicological consultation data management system based on experience of Pomeranian Center of Toxicology].

    Science.gov (United States)

    Kabata, Piotr Maciej; Waldman, Wojciech; Sein Anand, Jacek

    2015-01-01

    In this paper the structure of poisonings is described, based on the material collected from tele-toxicology consults by the Pomeranian Center of Toxicology in Gdańsk and harvested from its Electronic Poison Information Management System. In addition, we analyzed conclusions drawn from a 27-month operation of the system. Data were harvested from the Electronic Poison Information Management System developed in 2012 and used by the Pomeranian Center of Toxicology since then. The research was based on 2550 tele-toxicology consults between January 1 and December 31, 2014. Subsequently the data were electronically cleaned and presented using R programming language. The Pomeranian voivodeship was the prevalent localisation of calls (N = 1879; 73.7%). Most of the calls came from emergency rooms (N = 1495; 58.63%). In the case of 1396 (54.7%) patients the time-lag between intoxication and the consult was less than 6 h. There were no differences in the age distribution between genders. Mean age was 26.3 years. Young people predominated among intoxicated individuals. The majority of intoxications were incidental (N = 888; 34.8%) or suicidal (N = 814; 31.9%) and the most of them took place in the patient's home. Information about Poison Control Center consultations access should be better spread among medical service providers. The extent of poison information collected by Polish Poison Control Centers should be limited and unified. This should contribute to the increased percentage of properly documented consultations. Additional duties stemming from the need of digital archiving of consults provided, require the involvement of additional staff, leading to the increased operation costs incurred by Poison Control Centers. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  6. Insensitive Enough Semantics

    Directory of Open Access Journals (Sweden)

    Richard Vallée

    2006-06-01

    Full Text Available According to some philosophers, sentences like (1 “It is raining” and (2 “John is ready” are context sensitive sentences even if they do not contain indexicals or demonstratives. That view initiated a context sensitivity frenzy. Cappelen and Lepore (2005 summarize the frenzy by the slogan “Every sentence is context sensitive” (Insensitive Semantics, p. 6, note 5. They suggest a view they call Minimalism according to which the truth conditions of utterances of sentences like (1/(2 are exactly what Convention T gives you. I will distinguish different propositions, and refocus semantics on sentences. As distinct from what the protagonists in the ongoing debate think, I argue that the content or truth conditions of utterances of both context sensitive sentences and sentences like (1/(2 are not interesting from a semantic point of view, and that the problem sentences like (1/(2 raises is not about context sensitivity or context insensitivity of sentences, but relevance of the content of utterances.

  7. Causality in the semantics of Esterel : revisited

    NARCIS (Netherlands)

    Mousavi, M.R.; Klin, B.; Sobocinski, P.

    2010-01-01

    We re-examine the challenges concerning causality in the semantics of Esterel and show that they pertain to the known issues in the semantics of Structured Operational Semantics with negative premises. We show that the solutions offered for the semantics of SOS also provide answers to the semantic

  8. Chemical Entity Semantic Specification: Knowledge representation for efficient semantic cheminformatics and facile data integration

    Science.gov (United States)

    2011-01-01

    Background Over the past several centuries, chemistry has permeated virtually every facet of human lifestyle, enriching fields as diverse as medicine, agriculture, manufacturing, warfare, and electronics, among numerous others. Unfortunately, application-specific, incompatible chemical information formats and representation strategies have emerged as a result of such diverse adoption of chemistry. Although a number of efforts have been dedicated to unifying the computational representation of chemical information, disparities between the various chemical databases still persist and stand in the way of cross-domain, interdisciplinary investigations. Through a common syntax and formal semantics, Semantic Web technology offers the ability to accurately represent, integrate, reason about and query across diverse chemical information. Results Here we specify and implement the Chemical Entity Semantic Specification (CHESS) for the representation of polyatomic chemical entities, their substructures, bonds, atoms, and reactions using Semantic Web technologies. CHESS provides means to capture aspects of their corresponding chemical descriptors, connectivity, functional composition, and geometric structure while specifying mechanisms for data provenance. We demonstrate that using our readily extensible specification, it is possible to efficiently integrate multiple disparate chemical data sources, while retaining appropriate correspondence of chemical descriptors, with very little additional effort. We demonstrate the impact of some of our representational decisions on the performance of chemically-aware knowledgebase searching and rudimentary reaction candidate selection. Finally, we provide access to the tools necessary to carry out chemical entity encoding in CHESS, along with a sample knowledgebase. Conclusions By harnessing the power of Semantic Web technologies with CHESS, it is possible to provide a means of facile cross-domain chemical knowledge integration with full

  9. Fundamentals of analytical toxicology

    National Research Council Canada - National Science Library

    Flanagan, R.J; Taylor, A; Watson, I.D; Whelpton, R

    2007-01-01

    ... may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except under the terms of the Cop...

  10. Pulmonary toxicology of respirable particles

    International Nuclear Information System (INIS)

    Sanders, C.L.; Cross, F.T.; Dagle, G.E.; Mahaffey, J.A.

    1980-09-01

    Separate abstracts were prepared for the 44 papers presented in these proceedings that deal will radioactive particles. The last paper (Stannard) in the proceedings is an historical review of the field of inhalation toxicology and is not included in the analytics

  11. Surprises and omissions in toxicology

    Czech Academy of Sciences Publication Activity Database

    Rašková, H.; Zídek, Zdeněk

    2004-01-01

    Roč. 12, - (2004), S94-S96 ISSN 1210-7778. [Inderdisciplinary Czech-Slovak Toxicological Conference /8./. Praha, 03.09.2004-05.09.2004] Institutional research plan: CEZ:AV0Z5008914 Keywords : bacterial toxins Subject RIV: FR - Pharmacology ; Medidal Chemistry

  12. Subliminal semantic priming in speech.

    Directory of Open Access Journals (Sweden)

    Jérôme Daltrozzo

    Full Text Available Numerous studies have reported subliminal repetition and semantic priming in the visual modality. We transferred this paradigm to the auditory modality. Prime awareness was manipulated by a reduction of sound intensity level. Uncategorized prime words (according to a post-test were followed by semantically related, unrelated, or repeated target words (presented without intensity reduction and participants performed a lexical decision task (LDT. Participants with slower reaction times in the LDT showed semantic priming (faster reaction times for semantically related compared to unrelated targets and negative repetition priming (slower reaction times for repeated compared to semantically related targets. This is the first report of semantic priming in the auditory modality without conscious categorization of the prime.

  13. Hierarchical Semantic Model of Geovideo

    Directory of Open Access Journals (Sweden)

    XIE Xiao

    2015-05-01

    Full Text Available The public security incidents were getting increasingly challenging with regard to their new features, including multi-scale mobility, multistage dynamic evolution, as well as spatiotemporal concurrency and uncertainty in the complex urban environment. However, the existing video models, which were used/designed for independent archive or local analysis of surveillance video, have seriously inhibited emergency response to the urgent requirements.Aiming at the explicit representation of change mechanism in video, the paper proposed a novel hierarchical geovideo semantic model using UML. This model was characterized by the hierarchical representation of both data structure and semantics based on the change-oriented three domains (feature domain, process domain and event domain instead of overall semantic description of video streaming; combining both geographical semantics and video content semantics, in support of global semantic association between multiple geovideo data. The public security incidents by video surveillance are inspected as an example to illustrate the validity of this model.

  14. The geometric semantics of algebraic quantum mechanics.

    Science.gov (United States)

    Cruz Morales, John Alexander; Zilber, Boris

    2015-08-06

    In this paper, we will present an ongoing project that aims to use model theory as a suitable mathematical setting for studying the formalism of quantum mechanics. We argue that this approach provides a geometric semantics for such a formalism by means of establishing a (non-commutative) duality between certain algebraic and geometric objects. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  15. [The challenges of the ethics of personalism to clinical toxicology].

    Science.gov (United States)

    Brusiło, Jerzy

    2011-01-01

    The fields of philosophical anthropology and the ethics of personalism overlap in the area of many difficult personal situations involving clinical toxicology. These therapeutic situations need an integral, multidimensional, and personal approach for both the patient and the toxicologist. This means that man is treated not only as a physical (biological) being but also there is an appreciation for the mental sphere, which includes rational, emotional, and spiritual elements while not forgetting that the human person is also part of the human community. Studying such an individual's personal decision as suicide, we must realize that it's not just physiological or biochemical poisons but also includes the poisoning of the psyche, as well as poisoning relationships with loved ones (family), poisoning social relations (in school or the workplace) and poisoning the spirit, in other words, there is no meaning in life itself, nor the meaning of God's existence, nor the meaning of faith, hope and love. Not only is there a greater "variety of poisons" than before, they are much more extensive and deep. For example, we can name environmental pollution, industrial poisons, chemical waste, genetic modification, powerful medications, or even the toxic social environment of evil ideas, malicious manipulation of the human mind (destructive religious sects). In approaching the challenges of clinical toxicology, the doctor must not only be a specialist in chemistry, biochemistry and pharmacology. What then is of future of toxicology because of this human dimension (anthropological, ethical and spiritual) of this teaching? As today marks the occasion of the 45th anniversary of the Clinic of Toxicology CM UJ, should we shape the ethos of young doctors who want to deal with toxicology seriously?

  16. Survey of semantic modeling techniques

    Energy Technology Data Exchange (ETDEWEB)

    Smith, C.L.

    1975-07-01

    The analysis of the semantics of programing languages was attempted with numerous modeling techniques. By providing a brief survey of these techniques together with an analysis of their applicability for answering semantic issues, this report attempts to illuminate the state-of-the-art in this area. The intent is to be illustrative rather than thorough in the coverage of semantic models. A bibliography is included for the reader who is interested in pursuing this area of research in more detail.

  17. Semantic multimedia analysis and processing

    CERN Document Server

    Spyrou, Evaggelos; Mylonas, Phivos

    2014-01-01

    Broad in scope, Semantic Multimedia Analysis and Processing provides a complete reference of techniques, algorithms, and solutions for the design and the implementation of contemporary multimedia systems. Offering a balanced, global look at the latest advances in semantic indexing, retrieval, analysis, and processing of multimedia, the book features the contributions of renowned researchers from around the world. Its contents are based on four fundamental thematic pillars: 1) information and content retrieval, 2) semantic knowledge exploitation paradigms, 3) multimedia personalization, and 4)

  18. Regulatory issues in accreditation of toxicology laboratories.

    Science.gov (United States)

    Bissell, Michael G

    2012-09-01

    Clinical toxicology laboratories and forensic toxicology laboratories operate in a highly regulated environment. This article outlines major US legal/regulatory issues and requirements relevant to accreditation of toxicology laboratories (state and local regulations are not covered in any depth). The most fundamental regulatory distinction involves the purposes for which the laboratory operates: clinical versus nonclinical. The applicable regulations and the requirements and options for operations depend most basically on this consideration, with clinical toxicology laboratories being directly subject to federal law including mandated options for accreditation and forensic toxicology laboratories being subject to degrees of voluntary or state government–required accreditation.

  19. The Semantics of Heart: Translation Problems

    Directory of Open Access Journals (Sweden)

    Hortensia Pârlog

    2005-06-01

    Full Text Available Words hardly ever occur on their own, because they can hardly mean anything on their own, when asked about the meaning of an isolated word, in order to figure it out, what one does is try to place it in a context or use it in a collocation. The verbal contexts in which words appear influence or at least clarify their semantic value, it is because of contextual factors that a word may have more than one meaning. Therefore, the analysis above word level is extremely important. An analysis of translational decisions may also prove to be a valuable source of information in establishing the semantics of a lexical item. The above statements are illustrated by discussing the semantics of heart. The word occurs in a great number of structures in both English and Romanian, of which eight will be analysed: heart + verb, verb + heart, heart + of phrase, adjective + heart, heart + head noun, head noun +of heart, adjective + preposition + heart, heart in sayings or fixed expressions.

  20. Semantic Representatives of the Concept

    Directory of Open Access Journals (Sweden)

    Elena N. Tsay

    2013-01-01

    Full Text Available In the article concept as one of the principle notions of cognitive linguistics is investigated. Considering concept as culture phenomenon, having language realization and ethnocultural peculiarities, the description of the concept “happiness” is presented. Lexical and semantic paradigm of the concept of happiness correlates with a great number of lexical and semantic variants. In the work semantic representatives of the concept of happiness, covering supreme spiritual values are revealed and semantic interpretation of their functioning in the Biblical discourse is given.

  1. System semantics of explanatory dictionaries

    Directory of Open Access Journals (Sweden)

    Volodymyr Shyrokov

    2015-11-01

    Full Text Available System semantics of explanatory dictionaries Some semantic properties of the language to be followed from the structure of lexicographical systems of big explanatory dictionaries are considered. The hyperchains and hypercycles are determined as the definite kind of automorphisms of the lexicographical system of explanatory dictionary. Some semantic consequencies following from the principles of lexicographic closure and lexicographic completeness are investigated using the hyperchains and hypercycles formalism. The connection between the hypercyle properties of the lexicographical system semantics and Goedel’s incompleteness theorem is discussed.

  2. The Interaction between Semantic Representation and Episodic Memory.

    Science.gov (United States)

    Fang, Jing; Rüther, Naima; Bellebaum, Christian; Wiskott, Laurenz; Cheng, Sen

    2018-02-01

    The experimental evidence on the interrelation between episodic memory and semantic memory is inconclusive. Are they independent systems, different aspects of a single system, or separate but strongly interacting systems? Here, we propose a computational role for the interaction between the semantic and episodic systems that might help resolve this debate. We hypothesize that episodic memories are represented as sequences of activation patterns. These patterns are the output of a semantic representational network that compresses the high-dimensional sensory input. We show quantitatively that the accuracy of episodic memory crucially depends on the quality of the semantic representation. We compare two types of semantic representations: appropriate representations, which means that the representation is used to store input sequences that are of the same type as those that it was trained on, and inappropriate representations, which means that stored inputs differ from the training data. Retrieval accuracy is higher for appropriate representations because the encoded sequences are less divergent than those encoded with inappropriate representations. Consistent with our model prediction, we found that human subjects remember some aspects of episodes significantly more accurately if they had previously been familiarized with the objects occurring in the episode, as compared to episodes involving unfamiliar objects. We thus conclude that the interaction with the semantic system plays an important role for episodic memory.

  3. Semantic Technologies for Nuclear Knowledge Modelling and Applications

    International Nuclear Information System (INIS)

    Beraha, D.; Gladyshev, M.

    2016-01-01

    Full text: The IAEA has been engaged in working with Member States to preserve and enhance nuclear knowledge, and in supporting wide dissemination of safety related technical and technological information enhancing nuclear safety. The knowledge organization systems (ontologies, taxonomies, thesauri, etc.) provide one of the means to model and structure a given knowledge domain. The significance of knowledge organization systems (KOS) has been greatly enhanced by the evolution of the semantic technologies, enabling machines to “understand” the concepts described in a KOS, and to use them in a variety of applications. Over recent years semantic technologies have emerged as efficient means to improve access to information and knowledge. The Semantic Web Standards play an important role in creating an infrastructure of interoperable data sources based on principles of Linked Data. The status of utilizing semantic technologies in the nuclear domain is shortly reviewed, noting that such technologies are in their early stage of adoption, and considering some aspects which are specific to nuclear knowledge management. Several areas are described where semantic technologies are already deployed, and other areas are indicated where applications based on semantic technologies will have a strong impact on nuclear knowledge management in the near future. (author

  4. Semantic content-based recommendations using semantic graphs.

    Science.gov (United States)

    Guo, Weisen; Kraines, Steven B

    2010-01-01

    Recommender systems (RSs) can be useful for suggesting items that might be of interest to specific users. Most existing content-based recommendation (CBR) systems are designed to recommend items based on text content, and the items in these systems are usually described with keywords. However, similarity evaluations based on keywords suffer from the ambiguity of natural languages. We present a semantic CBR method that uses Semantic Web technologies to recommend items that are more similar semantically with the items that the user prefers. We use semantic graphs to represent the items and we calculate the similarity scores for each pair of semantic graphs using an inverse graph frequency algorithm. The items having higher similarity scores to the items that are known to be preferred by the user are recommended.

  5. Personal semantics: at the crossroads of semantic and episodic memory.

    Science.gov (United States)

    Renoult, Louis; Davidson, Patrick S R; Palombo, Daniela J; Moscovitch, Morris; Levine, Brian

    2012-11-01

    Declarative memory is usually described as consisting of two systems: semantic and episodic memory. Between these two poles, however, may lie a third entity: personal semantics (PS). PS concerns knowledge of one's past. Although typically assumed to be an aspect of semantic memory, it is essentially absent from existing models of knowledge. Furthermore, like episodic memory (EM), PS is idiosyncratically personal (i.e., not culturally-shared). We show that, depending on how it is operationalized, the neural correlates of PS can look more similar to semantic memory, more similar to EM, or dissimilar to both. We consider three different perspectives to better integrate PS into existing models of declarative memory and suggest experimental strategies for disentangling PS from semantic and episodic memory. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Modeling of the Case Grammatical Meaning

    Directory of Open Access Journals (Sweden)

    Алексей Львович Новиков

    2014-12-01

    Full Text Available The article raises the problem of constructing a semantic model to describe the meaning of the grammatical category of case in the languages of different types. The main objective of this publication - to provide an overview of different points of view on the semantic structure of the category of case and to compare different models of case semantics. Initial impulse to the development of problems of case semantics became the grammar and typological ideas of A.A. Potebnya and R. Jakobson. The basis of these models, which differ from each other in the number and nature of the allocation of features is the idea of the possibility of representing grammatical meaning as a structured set of semantic features. The analysis shows that the construction of formal models of grammatical categories is impossible without referring to the content of the dominant semantic features in the structure of grammatical meaning. Despite all the difficulties of modeling grammatical semantics, to construct a semantic model of case is an interesting and promising task of general morphology and typological linguistics.

  7. Connectionism and Compositional Semantics

    Science.gov (United States)

    1989-05-01

    can use their hidden layers to learn difficult discriminations. such as panty or the Penzias two clumps/three clumps problem, where the output is...sauce." For novel sentences that are similar to the training sentences (e.g., train on "the girl hit the boy," test on -the boy hit the girl "), the...overridden by semantic considerations. as in this example from Wendy Lehnert (personal communicanon): (5) John saw the girl with the telescope in a red

  8. A Semantics of Synchronization.

    Science.gov (United States)

    1980-09-01

    suggestion of having very hungry philosophers. One can easily imagine the complexity of the equivalent implementation using semaphores . Synchronization types...Edinburgh, July 1978. [STAR79] Stark, E.W., " Semaphore Primitives and Fair Mutual Exclusion," TM-158, Laboratory for Computer Science, M.I.T., Cambridge...AD-AQ91 015 MASSACHUSETTS INST OF TECH CAMBRIDGE LAB FOR COMPUTE--ETC F/S 9/2 A SEMANTICS OF SYNCHRONIZATION .(U) .C SEP 80 C A SEAQUIST N00015-75

  9. Semantic projection: recovering human knowledge of multiple, distinct object features from word embeddings

    OpenAIRE

    Grand, Gabriel; Blank, Idan Asher; Pereira, Francisco; Fedorenko, Evelina

    2018-01-01

    The words of a language reflect the structure of the human mind, allowing us to transmit thoughts between individuals. However, language can represent only a subset of our rich and detailed cognitive architecture. Here, we ask what kinds of common knowledge (semantic memory) are captured by word meanings (lexical semantics). We examine a prominent computational model that represents words as vectors in a multidimensional space, such that proximity between word-vectors approximates semantic re...

  10. A Generalization of Inquisitive Semantics

    Czech Academy of Sciences Publication Activity Database

    Punčochář, Vít

    2016-01-01

    Roč. 45, č. 4 (2016), s. 399-428 ISSN 0022-3611 R&D Projects: GA ČR(CZ) GA13-21076S Institutional support: RVO:67985955 Keywords : Intuitionistic logic * Superintuitionistic logics * Inquisitive logic * Topological semantics * Kripke semantics * Disjunction Subject RIV: AA - Philosophy ; Religion

  11. The Problem of Naturalizing Semantics.

    Science.gov (United States)

    Sullivan, Arthur

    2000-01-01

    Investigates conceptual barriers prevalent in the works of both proponents and opponents of semantic naturalism. Searches for a tenable definition of naturalism according to which one can be a realist, a non-reductionist, and a naturalist about semantic content. (Author/VWL)

  12. On the Semantics of Focus

    Science.gov (United States)

    Kess, Joseph F.

    1975-01-01

    This article discusses the semantics of the notion of focus, insofar as it relates to Filipino languages. The evolution of this notion is reviewed, and an alternative explanation of it is given, stressing the fact that grammar and semantics should be kept separate in a discussion of focus. (CLK)

  13. Semantic web in the e-learning

    Directory of Open Access Journals (Sweden)

    Andrenizia Aquino Eluan

    2008-01-01

    Full Text Available With the evolution of the technology of information and communication, the Web is adding diversity of resources that can facilitate the development of some areas of the knowledge, because promotes the access and the use of information globalised, accessible and without borders. Discusses the semantic Web as a means of sharing information to adopt standards for interoperability to the communication in network. Among the concerns that surround the education area, are the strategies of search and information retrieval in a relevant and effective for the knowledge of construction and learning. In this context, is the Distance Education, which area can enjoy the resources of the Semantic Web and the advantages of using ontology, which will be presented in this article

  14. Safety and Toxicology of Cannabinoids

    OpenAIRE

    Sachs, Jane; McGlade, Erin; Yurgelun-Todd, Deborah

    2015-01-01

    There is extensive research on the safety, toxicology, potency, and therapeutic potential of cannabis. However, uncertainty remains facilitating continued debate on medical and recreational cannabis policies at the state and federal levels. This review will include a brief description of cannabinoids and the endocannabinoid system; a summary of the acute and long-term effects of cannabis; and a discussion of the therapeutic potential of cannabis. The conclusions about safety and efficacy will...

  15. Semantic Coherence Facilitates Distributional Learning.

    Science.gov (United States)

    Ouyang, Long; Boroditsky, Lera; Frank, Michael C

    2017-04-01

    Computational models have shown that purely statistical knowledge about words' linguistic contexts is sufficient to learn many properties of words, including syntactic and semantic category. For example, models can infer that "postman" and "mailman" are semantically similar because they have quantitatively similar patterns of association with other words (e.g., they both tend to occur with words like "deliver," "truck," "package"). In contrast to these computational results, artificial language learning experiments suggest that distributional statistics alone do not facilitate learning of linguistic categories. However, experiments in this paradigm expose participants to entirely novel words, whereas real language learners encounter input that contains some known words that are semantically organized. In three experiments, we show that (a) the presence of familiar semantic reference points facilitates distributional learning and (b) this effect crucially depends both on the presence of known words and the adherence of these known words to some semantic organization. Copyright © 2016 Cognitive Science Society, Inc.

  16. Polish Semantic Parser

    Directory of Open Access Journals (Sweden)

    Agnieszka Grudzinska

    2000-01-01

    Full Text Available Amount of information transferred by computers grows very rapidly thus outgrowing the average man's capability of reception. It implies computer programs increase in the demand for which would be able to perform an introductory classitication or even selection of information directed to a particular receiver. Due to the complexity of the problem, we restricted it to understanding short newspaper notes. Among many conceptions formulated so far, the conceptual dependency worked out by Roger Schank has been chosen. It is a formal language of description of the semantics of pronouncement integrated with a text understanding algorithm. Substantial part of each text transformation system is a semantic parser of the Polish language. It is a module, which as the first and the only one has an access to the text in the Polish language. lt plays the role of an element, which finds relations between words of the Polish language and the formal registration. It translates sentences written in the language used by people into the language theory. The presented structure of knowledge units and the shape of understanding process algorithms are universal by virtue of the theory. On the other hand the defined knowledge units and the rules used in the algorithms ure only examples because they are constructed in order to understand short newspaper notes.

  17. Communication as Sociocultural Meaning Exchange:

    Directory of Open Access Journals (Sweden)

    Iyabode Omolara Akewo Daniel

    2013-09-01

    Full Text Available Communication is expected to result in meaning exchange. However, when definite meanings could not be established in a communication exchange, an odd situation usually results. Such situations are observed to actually go beyond syntactic and logical misnomer in the communication process. This paper thus examines the semantic oddities in Richard Wright’s Black Boy. It made use of the linkage points of such linguistic approaches like pragmatics, semiotics, presupposition and truth-condition semantics to do a semantic analysis of the novel. It found that sociological factors have a great deal of influence on the odd way of interpreting utterances/communication signals in the text. The paper therefore advocates that there is the need to incorporate co-text sociological elements as being of relevance to meaning analysis.

  18. Semantic Priming During Sentence Processing by Young and Older Adults.

    Science.gov (United States)

    Burke, Deborah M.; Yee, Penny L.

    1984-01-01

    Compares the semantic processing skills of younger adults (mean age 25) and older adults (mean age 68). After reading a sentence, subjects performed a task in which responses did not depend on retention. Results provided no evidence for age-related changes, including those associated with access to implied information. (Author/RH)

  19. 21 CFR 862.3200 - Clinical toxicology calibrator.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Clinical toxicology calibrator. 862.3200 Section... (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Toxicology Test Systems § 862.3200 Clinical toxicology calibrator. (a) Identification. A clinical toxicology calibrator is...

  20. Resource Guide to Careers in Toxicology, 3rd Edition.

    Science.gov (United States)

    Society of Toxicology, Reston, VA.

    This resource guide was prepared by the Tox 90's Educational Issues Task Force of the Society of Toxicology. The introduction provides information on the Society of Toxicology and financial support for graduate students in toxicology. Other sections include career opportunities in toxicology, academic and postdoctoral programs in toxicology, and…

  1. Postmortem aviation forensic toxicology: an overview.

    Science.gov (United States)

    Chaturvedi, Arvind K

    2010-05-01

    An overview of the subtopic aviation combustion toxicology of the field of aerospace toxicology has been published. In a continuation of the overview, the findings associated with postmortem aviation forensic toxicology are being summarized in the present overview. A literature search for the period of 1960-2007 was performed. The important findings related to postmortem toxicology were evaluated. In addition to a brief introduction, this overview is divided into the sections of analytical methods; carboxyhemoglobin and blood cyanide ion; ethanol; drugs; result interpretation; glucose and hemoglobin A(1c); and references. Specific details of the subject matter were discussed. It is anticipated that this overview will be an outline source for aviation forensic toxicology within the field of aerospace toxicology.

  2. Semantic web data warehousing for caGrid.

    Science.gov (United States)

    McCusker, James P; Phillips, Joshua A; González Beltrán, Alejandra; Finkelstein, Anthony; Krauthammer, Michael

    2009-10-01

    The National Cancer Institute (NCI) is developing caGrid as a means for sharing cancer-related data and services. As more data sets become available on caGrid, we need effective ways of accessing and integrating this information. Although the data models exposed on caGrid are semantically well annotated, it is currently up to the caGrid client to infer relationships between the different models and their classes. In this paper, we present a Semantic Web-based data warehouse (Corvus) for creating relationships among caGrid models. This is accomplished through the transformation of semantically-annotated caBIG Unified Modeling Language (UML) information models into Web Ontology Language (OWL) ontologies that preserve those semantics. We demonstrate the validity of the approach by Semantic Extraction, Transformation and Loading (SETL) of data from two caGrid data sources, caTissue and caArray, as well as alignment and query of those sources in Corvus. We argue that semantic integration is necessary for integration of data from distributed web services and that Corvus is a useful way of accomplishing this. Our approach is generalizable and of broad utility to researchers facing similar integration challenges.

  3. Ontology-based knowledge representation for resolution of semantic heterogeneity in GIS

    Science.gov (United States)

    Liu, Ying; Xiao, Han; Wang, Limin; Han, Jialing

    2017-07-01

    Lack of semantic interoperability in geographical information systems has been identified as the main obstacle for data sharing and database integration. The new method should be found to overcome the problems of semantic heterogeneity. Ontologies are considered to be one approach to support geographic information sharing. This paper presents an ontology-driven integration approach to help in detecting and possibly resolving semantic conflicts. Its originality is that each data source participating in the integration process contains an ontology that defines the meaning of its own data. This approach ensures the automation of the integration through regulation of semantic integration algorithm. Finally, land classification in field GIS is described as the example.

  4. Semantic attributes based texture generation

    Science.gov (United States)

    Chi, Huifang; Gan, Yanhai; Qi, Lin; Dong, Junyu; Madessa, Amanuel Hirpa

    2018-04-01

    Semantic attributes are commonly used for texture description. They can be used to describe the information of a texture, such as patterns, textons, distributions, brightness, and so on. Generally speaking, semantic attributes are more concrete descriptors than perceptual features. Therefore, it is practical to generate texture images from semantic attributes. In this paper, we propose to generate high-quality texture images from semantic attributes. Over the last two decades, several works have been done on texture synthesis and generation. Most of them focusing on example-based texture synthesis and procedural texture generation. Semantic attributes based texture generation still deserves more devotion. Gan et al. proposed a useful joint model for perception driven texture generation. However, perceptual features are nonobjective spatial statistics used by humans to distinguish different textures in pre-attentive situations. To give more describing information about texture appearance, semantic attributes which are more in line with human description habits are desired. In this paper, we use sigmoid cross entropy loss in an auxiliary model to provide enough information for a generator. Consequently, the discriminator is released from the relatively intractable mission of figuring out the joint distribution of condition vectors and samples. To demonstrate the validity of our method, we compare our method to Gan et al.'s method on generating textures by designing experiments on PTD and DTD. All experimental results show that our model can generate textures from semantic attributes.

  5. History of Japanese Society of Toxicology.

    Science.gov (United States)

    Satoh, Tetsuo

    2016-01-01

    Founded in 1981, the Japanese Society of Toxicology (JSOT) has grown into an organization of nearly 3,000 members working together to advance the nation's scientific knowledge and understanding of toxicology through the implementation of planning that ensures a systematic and efficient expenditure of energies and resources, and is closely aligned with a strategy for accomplishing the Society's long-range plans. To promote public education in toxicology, the Society organizes public lectures during each year's annual meeting. Other activities include hosting scientific conferences, promoting continuing education, and facilitating international collaboration. Internally, the JSOT operates five standing committees: General Affairs, Educational, Editorial, Finance, and Science and Publicity to handle its necessary relationships. To bestow official recognition, the Society established its Toxicologist Certification Program in 1997, and has certified 536 members as Diplomat Toxicologists (DJSOT) as of May 1, 2016. Furthermore, on the same date, 43 JSOT members were certified as Emeritus Diplomats of the JSOT (EDJSOT). The Society has launched two official journals, the "Journal of Toxicological Sciences (JTS)" in 1981 and "Fundamental Toxicological Sciences (Fundam. Toxicol. Sci.)" in 2014. As for participation in the international organizations, the JSOT (then known as the Toxicological Research Group) joined the International Union of Toxicology as a charter member in 1980, and became a founding member of the Asian Society of Toxicology at its inauguration in 1994. Into the future, the JSOT will continue working diligently to advance knowledge and understanding of toxicology and secure its place among the interdisciplinary fields of science, humane studies, and ethics.

  6. Mapping the Structure of Semantic Memory

    Science.gov (United States)

    Morais, Ana Sofia; Olsson, Henrik; Schooler, Lael J.

    2013-01-01

    Aggregating snippets from the semantic memories of many individuals may not yield a good map of an individual's semantic memory. The authors analyze the structure of semantic networks that they sampled from individuals through a new snowball sampling paradigm during approximately 6 weeks of 1-hr daily sessions. The semantic networks of individuals…

  7. Adaptive semantics visualization

    CERN Document Server

    Nazemi, Kawa

    2016-01-01

    This book introduces a novel approach for intelligent visualizations that adapts the different visual variables and data processing to human’s behavior and given tasks. Thereby a number of new algorithms and methods are introduced to satisfy the human need of information and knowledge and enable a usable and attractive way of information acquisition. Each method and algorithm is illustrated in a replicable way to enable the reproduction of the entire “SemaVis” system or parts of it. The introduced evaluation is scientifically well-designed and performed with more than enough participants to validate the benefits of the methods. Beside the introduced new approaches and algorithms, readers may find a sophisticated literature review in Information Visualization and Visual Analytics, Semantics and information extraction, and intelligent and adaptive systems. This book is based on an awarded and distinguished doctoral thesis in computer science.

  8. Communication of Semantic Properties

    DEFF Research Database (Denmark)

    Lenau, Torben Anker; Boelskifte, Per

    2004-01-01

    The selection of materials and planning for production play a key role for the design of physical products. Product function, appearance and expression are influenced by the chosen materials and how they are shaped. However these properties are not carried by the material itself, but by the speci......The selection of materials and planning for production play a key role for the design of physical products. Product function, appearance and expression are influenced by the chosen materials and how they are shaped. However these properties are not carried by the material itself...... processes. This working paper argues for the need for a commonly accepted terminology used to communicate semantic product properties. Designers and others involved in design processes are dependent of a sharp and clear verbal communication. Search facilities in computer programs for product and material...

  9. 78 FR 45253 - National Toxicology Program Scientific Advisory Committee on Alternative Toxicological Methods...

    Science.gov (United States)

    2013-07-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Toxicology Program... Alternative Methods (ICCVAM), the National Toxicology Program (NTP) Interagency Center for the Evaluation of... Director, National Toxicology Program. [FR Doc. 2013-17919 Filed 7-25-13; 8:45 am] BILLING CODE 4140-01-P ...

  10. Semantic Location Extraction from Crowdsourced Data

    Science.gov (United States)

    Koswatte, S.; Mcdougall, K.; Liu, X.

    2016-06-01

    Crowdsourced Data (CSD) has recently received increased attention in many application areas including disaster management. Convenience of production and use, data currency and abundancy are some of the key reasons for attracting this high interest. Conversely, quality issues like incompleteness, credibility and relevancy prevent the direct use of such data in important applications like disaster management. Moreover, location information availability of CSD is problematic as it remains very low in many crowd sourced platforms such as Twitter. Also, this recorded location is mostly related to the mobile device or user location and often does not represent the event location. In CSD, event location is discussed descriptively in the comments in addition to the recorded location (which is generated by means of mobile device's GPS or mobile communication network). This study attempts to semantically extract the CSD location information with the help of an ontological Gazetteer and other available resources. 2011 Queensland flood tweets and Ushahidi Crowd Map data were semantically analysed to extract the location information with the support of Queensland Gazetteer which is converted to an ontological gazetteer and a global gazetteer. Some preliminary results show that the use of ontologies and semantics can improve the accuracy of place name identification of CSD and the process of location information extraction.

  11. SEMANTIC LOCATION EXTRACTION FROM CROWDSOURCED DATA

    Directory of Open Access Journals (Sweden)

    S. Koswatte

    2016-06-01

    Full Text Available Crowdsourced Data (CSD has recently received increased attention in many application areas including disaster management. Convenience of production and use, data currency and abundancy are some of the key reasons for attracting this high interest. Conversely, quality issues like incompleteness, credibility and relevancy prevent the direct use of such data in important applications like disaster management. Moreover, location information availability of CSD is problematic as it remains very low in many crowd sourced platforms such as Twitter. Also, this recorded location is mostly related to the mobile device or user location and often does not represent the event location. In CSD, event location is discussed descriptively in the comments in addition to the recorded location (which is generated by means of mobile device's GPS or mobile communication network. This study attempts to semantically extract the CSD location information with the help of an ontological Gazetteer and other available resources. 2011 Queensland flood tweets and Ushahidi Crowd Map data were semantically analysed to extract the location information with the support of Queensland Gazetteer which is converted to an ontological gazetteer and a global gazetteer. Some preliminary results show that the use of ontologies and semantics can improve the accuracy of place name identification of CSD and the process of location information extraction.

  12. Learning preferences from paired opposite-based semantics

    DEFF Research Database (Denmark)

    Franco de los Ríos, Camilo; Rodríguez, J. Tinguaro; Montero, Javier

    2017-01-01

    Preference semantics examine the meaning of the preference predicate, according to the way that alternatives can be understood and organized for decision making purposes. Through opposite-based semantics, preference structures can be characterized by their paired decomposition of preference...... on the character of opposition, the compound meaning of preference emerges from the fuzzy reinforcement of paired opposite concepts, searching for significant evidence for affirming dominance among the decision objects. Here we propose a general model for the paired decomposition of preference, examining its...

  13. Workspaces in the Semantic Web

    Science.gov (United States)

    Wolfe, Shawn R.; Keller, RIchard M.

    2005-01-01

    Due to the recency and relatively limited adoption of Semantic Web technologies. practical issues related to technology scaling have received less attention than foundational issues. Nonetheless, these issues must be addressed if the Semantic Web is to realize its full potential. In particular, we concentrate on the lack of scoping methods that reduce the size of semantic information spaces so they are more efficient to work with and more relevant to an agent's needs. We provide some intuition to motivate the need for such reduced information spaces, called workspaces, give a formal definition, and suggest possible methods of deriving them.

  14. Semantic acquisition games harnessing manpower for creating semantics

    CERN Document Server

    Šimko, Jakub

    2014-01-01

    A comprehensive and extensive review of state-of-the-art in semantics acquisition game (SAG) design A set of design patterns for SAG designers A set of case studies (real SAG projects) demonstrating the use of SAG design patterns

  15. High Performance Descriptive Semantic Analysis of Semantic Graph Databases

    Energy Technology Data Exchange (ETDEWEB)

    Joslyn, Cliff A.; Adolf, Robert D.; al-Saffar, Sinan; Feo, John T.; Haglin, David J.; Mackey, Greg E.; Mizell, David W.

    2011-06-02

    As semantic graph database technology grows to address components ranging from extant large triple stores to SPARQL endpoints over SQL-structured relational databases, it will become increasingly important to be able to understand their inherent semantic structure, whether codified in explicit ontologies or not. Our group is researching novel methods for what we call descriptive semantic analysis of RDF triplestores, to serve purposes of analysis, interpretation, visualization, and optimization. But data size and computational complexity makes it increasingly necessary to bring high performance computational resources to bear on this task. Our research group built a novel high performance hybrid system comprising computational capability for semantic graph database processing utilizing the large multi-threaded architecture of the Cray XMT platform, conventional servers, and large data stores. In this paper we describe that architecture and our methods, and present the results of our analyses of basic properties, connected components, namespace interaction, and typed paths such for the Billion Triple Challenge 2010 dataset.

  16. Reviewing the design of DAML+OIL : An ontology language for the Semantic Web

    NARCIS (Netherlands)

    Horrocks, Ian; Patel-Schneider, Peter F.; Van Harmelen, Frank

    2002-01-01

    In the current "Syntactic Web", uninterpreted syntactic constructs are given meaning only by private off-line agreements that are inaccessible to computers. In the Semantic Web vision, this is replaced by a web where both data and its semantic definition are accessible and manipulable by computer

  17. Semantically Induced Distortions of Visual Awareness in a Patient with Balint's Syndrome

    Science.gov (United States)

    Soto, David; Humphreys, Glyn W.

    2009-01-01

    We present data indicating that visual awareness for a basic perceptual feature (colour) can be influenced by the relation between the feature and the semantic properties of the stimulus. We examined semantic interference from the meaning of a colour word ("RED") on simple colour (ink related) detection responses in a patient with simultagnosia…

  18. Safety and Toxicology of Cannabinoids.

    Science.gov (United States)

    Sachs, Jane; McGlade, Erin; Yurgelun-Todd, Deborah

    2015-10-01

    There is extensive research on the safety, toxicology, potency, and therapeutic potential of cannabis. However, uncertainty remains facilitating continued debate on medical and recreational cannabis policies at the state and federal levels. This review will include a brief description of cannabinoids and the endocannabinoid system; a summary of the acute and long-term effects of cannabis; and a discussion of the therapeutic potential of cannabis. The conclusions about safety and efficacy will then be compared with the current social and political climate to suggest future policy directions and general guidelines.

  19. An Architecture for Semantically Interoperable Electronic Health Records.

    Science.gov (United States)

    Toffanello, André; Gonçalves, Ricardo; Kitajima, Adriana; Puttini, Ricardo; Aguiar, Atualpa

    2017-01-01

    Despite the increasing adhesion of electronic health records, the challenge of semantic interoperability remains unsolved. The fact that different parties can exchange messages does not mean they can understand the underlying clinical meaning, therefore, it cannot be assumed or treated as a requirement. This work introduces an architecture designed to achieve semantic interoperability, in a way which organizations that follow different policies may still share medical information through a common infrastructure comparable to an ecosystem, whose organisms are exemplified within the Brazilian scenario. Nonetheless, the proposed approach describes a service-oriented design with modules adaptable to different contexts. We also discuss the establishment of an enterprise service bus to mediate a health infrastructure defined on top of international standards, such as openEHR and IHE. Moreover, we argue that, in order to achieve truly semantic interoperability in a wide sense, a proper profile must be published and maintained.

  20. Semantic Knowledge Representation (SKR) API

    Data.gov (United States)

    U.S. Department of Health & Human Services — The SKR Project was initiated at NLM in order to develop programs to provide usable semantic representation of biomedical free text by building on resources...

  1. Problem Solving with General Semantics.

    Science.gov (United States)

    Hewson, David

    1996-01-01

    Discusses how to use general semantics formulations to improve problem solving at home or at work--methods come from the areas of artificial intelligence/computer science, engineering, operations research, and psychology. (PA)

  2. NASA and The Semantic Web

    Science.gov (United States)

    Ashish, Naveen

    2005-01-01

    We provide an overview of several ongoing NASA endeavors based on concepts, systems, and technology from the Semantic Web arena. Indeed NASA has been one of the early adopters of Semantic Web Technology and we describe ongoing and completed R&D efforts for several applications ranging from collaborative systems to airspace information management to enterprise search to scientific information gathering and discovery systems at NASA.

  3. Efficient computation of argumentation semantics

    CERN Document Server

    Liao, Beishui

    2013-01-01

    Efficient Computation of Argumentation Semantics addresses argumentation semantics and systems, introducing readers to cutting-edge decomposition methods that drive increasingly efficient logic computation in AI and intelligent systems. Such complex and distributed systems are increasingly used in the automation and transportation systems field, and particularly autonomous systems, as well as more generic intelligent computation research. The Series in Intelligent Systems publishes titles that cover state-of-the-art knowledge and the latest advances in research and development in intelligen

  4. Psycholinguistic measures for German verb pairs: Semantic transparency, semantic relatedness, verb family size, and age of reading acquisition.

    Science.gov (United States)

    Smolka, Eva; Eulitz, Carsten

    2018-06-18

    A central issue in visual and spoken word recognition is the lexical representation of complex words-in particular, whether the lexical representation of complex words depends on semantic transparency: Is a complex verb like understand lexically represented as a whole word or via its base stand, given that its meaning is not transparent from the meanings of its parts? To study this issue, a number of stimulus characteristics are of interest that are not yet available in public databases of German. This article provides semantic association ratings, lexical paraphrases, and vector-based similarity measures for German verbs, measuring (a) the semantic transparency between 1,259 complex verbs and their bases, (b) the semantic relatedness between 1,109 verb pairs with 432 different bases, and (c) the vector-based similarity measures of 846 verb pairs. Additionally, we include the verb regularity of all verbs and two counts of verb family size for 184 base verbs, as well as estimates of age of acquisition and age of reading for 200 verbs. Together with lemma and type frequencies from public lexical databases, all measures can be downloaded along with this article. Statistical analyses indicate that verb family size, morphological complexity, frequency, and verb regularity affect the semantic transparency and relatedness ratings as well as the age of acquisition estimates, indicating that these are relevant variables in psycholinguistic experiments. Although lexical paraphrases, vector-based similarity measures, and semantic association ratings may deliver complementary information, the interrater reliability of the semantic association ratings for each verb pair provides valuable information when selecting stimuli for psycholinguistic experiments.

  5. The Toxicology Education Summit: building the future of toxicology through education.

    Science.gov (United States)

    Barchowsky, Aaron; Buckley, Lorrene A; Carlson, Gary P; Fitsanakis, Vanessa A; Ford, Sue M; Genter, Mary Beth; Germolec, Dori R; Leavens, Teresa L; Lehman-McKeeman, Lois D; Safe, Stephen H; Sulentic, Courtney E W; Eidemiller, Betty J

    2012-06-01

    Toxicology and careers in toxicology, as well as many other scientific disciplines, are undergoing rapid and dramatic changes as new discoveries, technologies, and hazards advance at a blinding rate. There are new and ever increasing demands on toxicologists to keep pace with expanding global economies, highly fluid policy debates, and increasingly complex global threats to public health. These demands must be met with new paradigms for multidisciplinary, technologically complex, and collaborative approaches that require advanced and continuing education in toxicology and associated disciplines. This requires paradigm shifts in educational programs that support recruitment, development, and training of the modern toxicologist, as well as continued education and retraining of the midcareer professional to keep pace and sustain careers in industry, government, and academia. The Society of Toxicology convened the Toxicology Educational Summit to discuss the state of toxicology education and to strategically address educational needs and the sustained advancement of toxicology as a profession. The Summit focused on core issues of: building for the future of toxicology through educational programs; defining education and training needs; developing the "Total Toxicologist"; continued training and retraining toxicologists to sustain their careers; and, finally, supporting toxicology education and professional development. This report summarizes the outcomes of the Summit, presents examples of successful programs that advance toxicology education, and concludes with strategies that will insure the future of toxicology through advanced educational initiatives.

  6. The Emergence of Systematic Review in Toxicology.

    Science.gov (United States)

    Stephens, Martin L; Betts, Kellyn; Beck, Nancy B; Cogliano, Vincent; Dickersin, Kay; Fitzpatrick, Suzanne; Freeman, James; Gray, George; Hartung, Thomas; McPartland, Jennifer; Rooney, Andrew A; Scherer, Roberta W; Verloo, Didier; Hoffmann, Sebastian

    2016-07-01

    The Evidence-based Toxicology Collaboration hosted a workshop on "The Emergence of Systematic Review and Related Evidence-based Approaches in Toxicology," on November 21, 2014 in Baltimore, Maryland. The workshop featured speakers from agencies and organizations applying systematic review approaches to questions in toxicology, speakers with experience in conducting systematic reviews in medicine and healthcare, and stakeholders in industry, government, academia, and non-governmental organizations. Based on the workshop presentations and discussion, here we address the state of systematic review methods in toxicology, historical antecedents in both medicine and toxicology, challenges to the translation of systematic review from medicine to toxicology, and thoughts on the way forward. We conclude with a recommendation that as various agencies and organizations adapt systematic review methods, they continue to work together to ensure that there is a harmonized process for how the basic elements of systematic review methods are applied in toxicology. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology.

  7. 42 CFR 493.845 - Standard; Toxicology.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; Toxicology. 493.845 Section 493.845 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... These Tests § 493.845 Standard; Toxicology. (a) Failure to attain a score of at least 80 percent of...

  8. Graph-based Operational Semantics of a Lazy Functional Languages

    DEFF Research Database (Denmark)

    Rose, Kristoffer Høgsbro

    1992-01-01

    Presents Graph Operational Semantics (GOS): a semantic specification formalism based on structural operational semantics and term graph rewriting. Demonstrates the method by specifying the dynamic ...

  9. Blood transcriptomics: applications in toxicology

    Science.gov (United States)

    Joseph, Pius; Umbright, Christina; Sellamuthu, Rajendran

    2015-01-01

    The number of new chemicals that are being synthesized each year has been steadily increasing. While chemicals are of immense benefit to mankind, many of them have a significant negative impact, primarily owing to their inherent chemistry and toxicity, on the environment as well as human health. In addition to chemical exposures, human exposures to numerous non-chemical toxic agents take place in the environment and workplace. Given that human exposure to toxic agents is often unavoidable and many of these agents are found to have detrimental human health effects, it is important to develop strategies to prevent the adverse health effects associated with toxic exposures. Early detection of adverse health effects as well as a clear understanding of the mechanisms, especially at the molecular level, underlying these effects are key elements in preventing the adverse health effects associated with human exposure to toxic agents. Recent developments in genomics, especially transcriptomics, have prompted investigations into this important area of toxicology. Previous studies conducted in our laboratory and elsewhere have demonstrated the potential application of blood gene expression profiling as a sensitive, mechanistically relevant and practical surrogate approach for the early detection of adverse health effects associated with exposure to toxic agents. The advantages of blood gene expression profiling as a surrogate approach to detect early target organ toxicity and the molecular mechanisms underlying the toxicity are illustrated and discussed using recent studies on hepatotoxicity and pulmonary toxicity. Furthermore, the important challenges this emerging field in toxicology faces are presented in this review article. PMID:23456664

  10. Toxicological profile for thorium. Draft report (Final)

    International Nuclear Information System (INIS)

    1990-10-01

    The ATSDR Toxicological Profile for Thorium is intended to characterize succinctly the toxicological and health effects information for the substance. It identifies and reviews the key literature that describes the substance's toxicological properties. Other literature is presented but described in less detail. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profile begins with a public health statement, which describes in nontechnical language the substance's relevant toxicological properties. Following the statement is material that presents levels of significant human exposure and, where known, significant health effects. The adequacy of information to determine the substance's health effects is described. Research gaps in nontoxic and health effects information are described. Research gaps that are of significance to the protection of public health will be identified in a separate effort. The focus of the document is on health and toxicological information

  11. Toxicological profile for uranium. Final report

    International Nuclear Information System (INIS)

    1990-12-01

    The ATSDR Toxicological Profile for Uranium is intended to characterize succinctly the toxicological and health effects information for the substance. It identifies and reviews the key literature that describes the substances's toxicological properties. Other literature is presented but described in less detail. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profile begins with a public health statement, which describes in nontechnical language the substance's relevant toxicological properties. Following the statement is material that presents levels of significant human exposure and, where known, significant health effects. The adequacy of information to determine the substance's health effects is described. Research gaps in nontoxic and health effects information are described. Research gaps that are of significance to the protection of public health will be identified in a separate effort. The focus of the document is on health and toxicological information

  12. Toxicological profile for radon. Final report

    International Nuclear Information System (INIS)

    1990-12-01

    The ATSDR Toxicological Profile for Radon is intended to characterize succinctly the toxicological and health effects information for the substance. It identifies and reviews the key literature that describes the substance's toxicological properties. Other literature is presented but described in less detail. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profile begins with a public health statement, which describes in nontechnical language the substance's relevant toxicological properties. Following the statement is material that presents levels of significant human exposure and, where known, significant health effects. The adequacy of information to determine the substance's health effects is described. Research gaps in nontoxic and health effects information are described. Research gaps that are of significance to the protection of public health will be identified in a separate effort. The focus of the document is on health and toxicological information

  13. Toxicological profile for plutonium. Final report

    International Nuclear Information System (INIS)

    1990-12-01

    The ATSDR Toxicological Profile for Plutonium is intended to characterize succinctly the toxicological and health effects information for the substance. It identifies and reviews the key literature that describes the substance's toxicological properties. Other literature is presented but described in less detail. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profile begins with a public health statement, which describes in nontechnical language the substance's relevant toxicological properties. Following the statement is material that presents levels of significant human exposure and, where known, significant health effects. The adequacy of information to determine the substance's health effects is described. Research gaps in nontoxic and health effects information are described. Research gaps that are of significance to the protection of public health will be identified in a separate effort. The focus of the document is on health and toxicological information

  14. Toxicological profile for radium. Final report

    International Nuclear Information System (INIS)

    1990-12-01

    The ATSDR Toxicological Profile for Radium is intended to characterize succinctly the toxicological and health effects information for the substance. It identifies and reviews the key literature that describes the substances' toxicological properties. Other literature is presented but described in less detail. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profile begins with a public health statement, which describes in nontechnical language the substance's relevant toxicological properties. Following the statement is material that presents levels of significant human exposure and, where known, significant health effects. The adequacy of information to determine the substance's health effects is described. Research gaps in nontoxic and health effects information are described. Research gaps that are of significance to the protection of public health will be identified in a separate effort. The focus of the document is on health and toxicological information

  15. Toxicology

    Science.gov (United States)

    Macewen, J. W.

    1973-01-01

    Oxygen toxicity is examined, including the effects of oxygen partial pressure variations on toxicity and oxygen effects on ozone and nitrogen dioxide toxicity. Toxicity of fuels and oxidizers, such as hydrazines, are reported. Carbon monoxide, spacecraft threshold limit values, emergency exposure limits, spacecraft contaminants, and water quality standards for space missions are briefly summarized.

  16. Semantic processes leading to true and false memory formation in schizophrenia.

    Science.gov (United States)

    Paz-Alonso, Pedro M; Ghetti, Simona; Ramsay, Ian; Solomon, Marjorie; Yoon, Jong; Carter, Cameron S; Ragland, J Daniel

    2013-07-01

    Encoding semantic relationships between items on word lists (semantic processing) enhances true memories, but also increases memory distortions. Episodic memory impairments in schizophrenia (SZ) are strongly driven by failures to process semantic relations, but the exact nature of these relational semantic processing deficits is not well understood. Here, we used a false memory paradigm to investigate the impact of implicit and explicit semantic processing manipulations on episodic memory in SZ. Thirty SZ and 30 demographically matched healthy controls (HC) studied Deese/Roediger-McDermott (DRM) lists of semantically associated words. Half of the lists had strong implicit semantic associations and the remainder had low strength associations. Similarly, half of the lists were presented under "standard" instructions and the other half under explicit "relational processing" instructions. After study, participants performed recall and old/new recognition tests composed of targets, critical lures, and unrelated lures. HC exhibited higher true memories and better discriminability between true and false memory compared to SZ. High, versus low, associative strength increased false memory rates in both groups. However, explicit "relational processing" instructions positively improved true memory rates only in HC. Finally, true and false memory rates were associated with severity of disorganized and negative symptoms in SZ. These results suggest that reduced processing of semantic relationships during encoding in SZ may stem from an inability to implement explicit relational processing strategies rather than a fundamental deficit in the implicit activation and retrieval of word meanings from patients' semantic lexicon. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. A model-driven approach for representing clinical archetypes for Semantic Web environments.

    Science.gov (United States)

    Martínez-Costa, Catalina; Menárguez-Tortosa, Marcos; Fernández-Breis, Jesualdo Tomás; Maldonado, José Alberto

    2009-02-01

    The life-long clinical information of any person supported by electronic means configures his Electronic Health Record (EHR). This information is usually distributed among several independent and heterogeneous systems that may be syntactically or semantically incompatible. There are currently different standards for representing and exchanging EHR information among different systems. In advanced EHR approaches, clinical information is represented by means of archetypes. Most of these approaches use the Archetype Definition Language (ADL) to specify archetypes. However, ADL has some drawbacks when attempting to perform semantic activities in Semantic Web environments. In this work, Semantic Web technologies are used to specify clinical archetypes for advanced EHR architectures. The advantages of using the Ontology Web Language (OWL) instead of ADL are described and discussed in this work. Moreover, a solution combining Semantic Web and Model-driven Engineering technologies is proposed to transform ADL into OWL for the CEN EN13606 EHR architecture.

  18. Hair: a complementary source of bioanalytical information in forensic toxicology.

    Science.gov (United States)

    Barroso, Mário; Gallardo, Eugenia; Vieira, Duarte Nuno; López-Rivadulla, Manuel; Queiroz, João António

    2011-01-01

    Hair has been used for years in the assessment and documentation of human exposure to drugs, as it presents characteristics that make it extremely valuable for this purpose, namely the fact that sample collection is performed in a noninvasive manner, under close supervision, the possibility of collecting a specimen reflecting a similar timeline in the case of claims or suspicion of a leak in the chain of custody, and the increased window of detection for the drugs. For these reasons, testing for drugs in hair provides unique and useful information in several fields of toxicology, from which the most prominent is the possibility of studying individual drug use histories by means of segmental analysis. This paper will review the unique role of hair as a complementary sample in documenting human exposure to drugs in the fields of clinical and forensic toxicology and workplace drug testing.

  19. What Do Monkey Calls Mean?

    Science.gov (United States)

    Schlenker, Philippe; Chemla, Emmanuel; Zuberbühler, Klaus

    2016-12-01

    A field of primate linguistics is gradually emerging. It combines general questions and tools from theoretical linguistics with rich data gathered in experimental primatology. Analyses of several monkey systems have uncovered very simple morphological and syntactic rules and have led to the development of a primate semantics that asks new questions about the division of semantic labor between the literal meaning of monkey calls, additional mechanisms of pragmatic enrichment, and the environmental context. We show that comparative studies across species may validate this program and may in some cases help in reconstructing the evolution of monkey communication over millions of years. Copyright © 2016. Published by Elsevier Ltd.

  20. Why Are Verbs so Hard to Remember? Effects of Semantic Context on Memory for Verbs and Nouns

    Science.gov (United States)

    Earles, Julie L.; Kersten, Alan W.

    2017-01-01

    Three experiments test the theory that verb meanings are more malleable than noun meanings in different semantic contexts, making a previously seen verb difficult to remember when it appears in a new semantic context. Experiment 1 revealed that changing the direct object noun in a transitive sentence reduced recognition of a previously seen verb,…

  1. E-Learning System Overview Based on Semantic Web

    Science.gov (United States)

    Alsultanny, Yas A.

    2006-01-01

    The challenge of the semantic web is the provision of distributed information with well-defined meaning, understandable for different parties. e-Learning is efficient task relevant and just-in-time learning grown from the learning requirements of the new dynamically changing, distributed business world. In this paper we design an e-Learning system…

  2. Using General Semantics Principles in the Basic News Reporting Classroom.

    Science.gov (United States)

    Russell, Charles G.; Many, Paul

    1993-01-01

    Shows how certain principles of the study of semantics might be employed in the journalism curriculum as a means of enhancing student reporters' understanding that their perceptions are limited and subject to distortion. Provides a model for explaining these limitations. (HB)

  3. The Food Code in the Yakut Culture: Semantics and Functions

    Science.gov (United States)

    Gabysheva, Luiza Lvovna

    2016-01-01

    The relevance of researching the issue of a specific cultural meaning for a word in a folklore text is based on its being insufficiently studied and due to the importance for solving the problem of the folklore language semantic features. Yakut nominations for dairy products, which are the key words in the language of the Sakha people's folklore,…

  4. Some Semantic Properties of Romanian Interrogatives: "Care" and "Cine."

    Science.gov (United States)

    Vasiliu, E.

    The aim of this paper is to account for some semantic properties of Romanian interrogatives "ce" and "cine" by establishing some definite correlations between various contextual restrictions governing the use of these interrogative particles and the "meaning" which might be assigned to each of these particles in any…

  5. E-Learning for Depth in the Semantic Web

    Science.gov (United States)

    Shafrir, Uri; Etkind, Masha

    2006-01-01

    In this paper, we describe concept parsing algorithms, a novel semantic analysis methodology at the core of a new pedagogy that focuses learners attention on deep comprehension of the conceptual content of learned material. Two new e-learning tools are described in some detail: interactive concept discovery learning and meaning equivalence…

  6. Process-oriented semantic web search

    CERN Document Server

    Tran, DT

    2011-01-01

    The book is composed of two main parts. The first part is a general study of Semantic Web Search. The second part specifically focuses on the use of semantics throughout the search process, compiling a big picture of Process-oriented Semantic Web Search from different pieces of work that target specific aspects of the process.In particular, this book provides a rigorous account of the concepts and technologies proposed for searching resources and semantic data on the Semantic Web. To collate the various approaches and to better understand what the notion of Semantic Web Search entails, this bo

  7. CASL The Common Algebraic Specification Language Semantics

    DEFF Research Database (Denmark)

    Haxthausen, Anne

    1998-01-01

    This is version 1.0 of the CASL Language Summary, annotated by the CoFI Semantics Task Group with the semantics of constructs. This is the first complete but possibly imperfect version of the semantics. It was compiled prior to the CoFI workshop at Cachan in November 1998.......This is version 1.0 of the CASL Language Summary, annotated by the CoFI Semantics Task Group with the semantics of constructs. This is the first complete but possibly imperfect version of the semantics. It was compiled prior to the CoFI workshop at Cachan in November 1998....

  8. Quantification and Negation in Event Semantics

    Directory of Open Access Journals (Sweden)

    Lucas Champollion

    2010-12-01

    and Meaning’, Lecture Notes in Computer Science, vol. 6042, 203–212. Berlin, Germany: Springer.Carlson, Gregory N. 1977. Reference to Kinds in English. Ph.D. thesis, University of Massachusetts, Amherst, MA.Carlson, Gregory N. 1984. ‘Thematic roles and their role in semantic interpretation’. Linguistics 22: 259–279.http://dx.doi.org/10.1515/ling.1984.22.3.259Champollion, Lucas. 2010. Parts of a whole: Distributivity as a bridge between aspect and measurement. Ph.D. thesis, University of Pennsylvania, Philadelphia, PA.Champollion, Lucas, Tauberer, Josh & Romero, Maribel. 2007. ‘The Penn Lambda Calculator: Pedagogical software for natural language semantics’. In Tracy Holloway King & Emily Bender (eds. ‘Proceedings of the Grammar Engineering Across Frameworks(GEAF 2007 Workshop’, Stanford, CA: CSLI Online Publications.Condoravdi, Cleo. 2002. ‘Punctual until as a scalar NPI’. In Sharon Inkelas & Kristin Hanson (eds. ‘The nature of the word’, 631–654. Cambridge, MA: MIT Press.Csirmaz, Aniko. 2006. ‘Aspect, Negation and Quantifiers’. In Liliane Haegeman, Joan Maling, James McCloskey & Katalin E. Kiss (eds. ‘Event Structure And The Left Periphery’, Studies in Natural Language and Linguistic Theory, vol. 68, 225–253. SpringerNetherlands.Davidson, Donald. 1967. ‘The logical form of action sentences’. In Nicholas Rescher (ed. ‘The logic of decision and action’, 81–95. Pittsburgh, PA: University of Pittsburgh Press.de Swart, Henriëtte. 1996. ‘Meaning and use of not . . . until’. Journal of Semantics 13: 221–263.http://dx.doi.org/10.1093/jos/13.3.221de Swart, Henriëtte & Molendijk, Arie. 1999. ‘Negation and the temporal structure of narrative discourse’. Journal of Semantics 16: 1–42.http://dx.doi.org/10.1093/jos/16.1.1Dowty, David R. 1979. Word meaning and Montague grammar. Dordrecht, Netherlands: Reidel.Eckardt, Regine. 2010. ‘A Logic for Easy Linking Semantics’. In Maria Aloni, Harald Bastiaanse, Tikitu de

  9. Linguistic expressions and semantic processing a practical approach

    CERN Document Server

    Butler, Alastair

    2015-01-01

    This book introduces formal semantics techniques for a natural language processing audience. Methods discussed involve: (i) the denotational techniques used in model-theoretic semantics, which make it possible to determine whether a linguistic expression is true or false with respect to some model of the way things happen to be; and (ii) stages of interpretation, i.e., ways to arrive at meanings by evaluating and converting source linguistic expressions, possibly with respect to contexts, into output (logical) forms that could be used with (i). The book demonstrates that the methods allow w

  10. Introduction to semantic e-Science in biomedicine

    Directory of Open Access Journals (Sweden)

    Wang Yimin

    2007-05-01

    Full Text Available Abstract The Semantic Web technologies provide enhanced capabilities that allow data and the meaning of the data to be shared and reused across application, enterprise, and community boundaries, better enabling integrative research and more effective knowledge discovery. This special issue is intended to give an introduction of the state-of-the-art of Semantic Web technologies and describe how such technologies would be used to build the e-Science infrastructure for biomedical communities. Six papers have been selected and included, featuring different approaches and experiences in a variety of biomedical domains.

  11. SM4MQ: A Semantic Model for Multidimensional Queries

    DEFF Research Database (Denmark)

    Varga, Jovan; Dobrokhotova, Ekaterina; Romero, Oscar

    2017-01-01

    On-Line Analytical Processing (OLAP) is a data analysis approach to support decision-making. On top of that, Exploratory OLAP is a novel initiative for the convergence of OLAP and the Semantic Web (SW) that enables the use of OLAP techniques on SW data. Moreover, OLAP approaches exploit different......, sharing, and reuse on the SW. As OLAP is based on the underlying multidimensional (MD) data model we denote such queries as MD queries and define SM4MQ: A Semantic Model for Multidimensional Queries. Furthermore, we propose a method to automate the exploitation of queries by means of SPARQL. We apply...

  12. Taxonomy, Ontology and Semantics at Johnson Space Center

    Science.gov (United States)

    Berndt, Sarah Ann

    2011-01-01

    At NASA Johnson Space Center (JSC), the Chief Knowledge Officer has been developing the JSC Taxonomy to capitalize on the accomplishments of yesterday while maintaining the flexibility needed for the evolving information environment of today. A clear vision and scope for the semantic system is integral to its success. The vision for the JSC Taxonomy is to connect information stovepipes to present a unified view for information and knowledge across the Center, across organizations, and across decades. Semantic search at JSC means seemless integration of disparate information sets into a single interface. Ever increasing use, interest, and organizational participation mark successful integration and provide the framework for future application.

  13. Semantic guidance of eye movements in real-world scenes

    OpenAIRE

    Hwang, Alex D.; Wang, Hsueh-Cheng; Pomplun, Marc

    2011-01-01

    The perception of objects in our visual world is influenced by not only their low-level visual features such as shape and color, but also their high-level features such as meaning and semantic relations among them. While it has been shown that low-level features in real-world scenes guide eye movements during scene inspection and search, the influence of semantic similarity among scene objects on eye movements in such situations has not been investigated. Here we study guidance of eye movemen...

  14. Measurement of semantic similarity for land use and land cover classification systems

    Science.gov (United States)

    Deng, Dongpo

    2008-12-01

    Land use and land cover (LULC) data is essential to environmental and ecological research. However, semantic heterogeneous of land use and land cover classification are often resulted from different data resources, different cultural contexts, and different utilities. Therefore, there is need to develop a method to measure, compare and integrate between land cover categories. To understand the meaning and the use of terminology from different domains, the common ontology approach is used to acquire information regarding the meaning of terms, and to compare two terms to determine how they might be related. Ontology is a formal specification of a shared conceptualization of a domain of interest. LULC classification system is a ontology. The semantic similarity method is used to compare to entities of three LULC classification systems: CORINE (European Environmental Agency), Oregon State, USA), and Taiwan. The semantic properties and relations firstly have been extracted from their definitions of LULC classification systems. Then semantic properties and relations of categories in three LULC classification systems are mutually compared. The visualization of semantic proximity is finally presented to explore the similarity or dissimilarity of data. This study shows the semantic similarity method efficiently detect semantic distance in three LULC classification systems and find out the semantic similar objects.

  15. Semantic similarity between old and new items produces false alarms in recognition memory.

    Science.gov (United States)

    Montefinese, Maria; Zannino, Gian Daniele; Ambrosini, Ettore

    2015-09-01

    In everyday life, human beings can report memories of past events that did not occur or that occurred differently from the way they remember them because memory is an imperfect process of reconstruction and is prone to distortion and errors. In this recognition study using word stimuli, we investigated whether a specific operationalization of semantic similarity among concepts can modulate false memories while controlling for the possible effect of associative strength and word co-occurrence in an old-new recognition task. The semantic similarity value of each new concept was calculated as the mean cosine similarity between pairs of vectors representing that new concept and each old concept belonging to the same semantic category. Results showed that, compared with (new) low-similarity concepts, (new) high-similarity concepts had significantly higher probability of being falsely recognized as old, even after partialling out the effect of confounding variables, including associative relatedness and lexical co-occurrence. This finding supports the feature-based view of semantic memory, suggesting that meaning overlap and sharing of semantic features (which are greater when more similar semantic concepts are being processed) have an influence on recognition performance, resulting in more false alarms for new high-similarity concepts. We propose that the associative strength and word co-occurrence among concepts are not sufficient to explain illusory memories but is important to take into account also the effects of feature-based semantic relations, and, in particular, the semantic similarity among concepts.

  16. Method Development in Forensic Toxicology.

    Science.gov (United States)

    Peters, Frank T; Wissenbach, Dirk K; Busardo, Francesco Paolo; Marchei, Emilia; Pichini, Simona

    2017-01-01

    In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development. The presented article will provide an overview on the process of developing methods for forensic applications. This includes the definition of the method's purpose (e.g. qualitative vs quantitative) and the analytes to be included, choosing an appropriate sample matrix, setting up separation and detection systems as well as establishing a versatile sample preparation. Method development is concluded by an optimization process after which the new method is subject to method validation. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  17. Testing of Binders Toxicological Effects

    Science.gov (United States)

    Strokova, V.; Nelyubova, V.; Rykunova, M.

    2017-11-01

    The article presents the results of a study of the toxicological effect of binders with different compositions on the vital activity of plant and animal test-objects. The analysis of the effect on plant cultures was made on the basis of the phytotesting data. The study of the effect of binders on objects of animal origin was carried out using the method of short-term testing. Based on the data obtained, binders are ranked according to the degree of increase in the toxic effect: Gypsum → Portland cement → Slag Portland cement. Regardless of the test-object type, the influence of binders is due to the release of various elements (calcium ions or heavy metals) into the solution. In case of plant cultures, the saturation of the solution with elements has a positive effect (there is no inhibitory effect), and in case of animal specimens - an increase in the toxic effect.

  18. Information resources in toxicology--Italy

    International Nuclear Information System (INIS)

    Preziosi, Paolo; Dracos, Adriana; Marcello, Ida

    2003-01-01

    The purpose of the present paper is to provide an overview of current resources in the field of toxicology in Italy. The discussion will begin with a brief history of toxicology in this country, which includes the study of the toxicity of plants and other natural substances, and the birth of industrial and forensic toxicology. We will also provide information on research, education, and hazard control in the field of toxicology. Within this context we will examine the public bodies responsible for surveillance and regulatory activities, state-owned and private structures involved in toxicological research, and the educational programs and research activities of universities. Particular emphasis will be placed on the activities of the National Health Service, which plays an important role in areas such as clinical toxicology, food safety, and animal health, as well as those of national and regional agencies dedicated to the protection of the environment. The presentation will be organized as follows: - A Brief History of Toxicology in Italy; - Professional Societies; - National Health Service; - National Bodies; - Resources for the Environment; - Biomedical Websites; - Recent Publications; - Research Structures; - Graduate and Postgraduate Programs; - Legislation

  19. Predictive toxicology: the paths of the future

    International Nuclear Information System (INIS)

    Detilleux, Ph.; Vallier, L.; Legallais, C.; Leclerc, E.; Prot, J.M.; Choucha, L.; Baudoin, R.; Dufresne, M.; Gautier, A.; Carpentier, B.; Mansuy, D.; Pery, A.; Brochot, C.; Manivet, Ph.; Rabilloud, Th.; Spire, C.; Coumoul, X.; Junot, Ch.; Laprevote, O.; Le pape, A.; Le Guevel, R.; Tourneur, E.; Ben Mkaddem, S.; Chassin, C.; Aloulou, M.; Goujon, J.M.; Hertif, A.; Ouali, N.; Vimont, S.; Monteiro, R.; Rondeau, E.; Elbim, C.; Werts, C.; Vandewalle, A.; Ben Mkaddem, S.; Pedruzzi, E.; Coant, N.; Bens, M.; Cluzeaud, F.; Ogier-Denis, E.; Pongnimitprasert, N.; Babin-Chevaye, C.; Fay, M.; Bernard, M.; Dupuy, C.; Ei Benna, J.; Gougerot-Pocidale, M.A.; Braut-Boucher, F.; Pinton, Ph.; Lucioli, J.; Tsybulskyy, D.; Joly, B.; Laffitte, J.; Bourges-Abella, N.; Oswald, I.P.; Kolf-Clauw, M.; Pierre, St.; Bats, A.S.; Chevallier, A.; Bui, L.Ch.; Ambolet-Camoit, A.; Garlatti, M.; Aggerbeck, M.; Barouki, R.; Al Khansa, I.; Blanck, O.; Guillouzo, A.; Bars, R.; Rouas, C.; Bensoussan, H.; Suhard, D.; Tessier, C.; Grandcolas, L.; Pallardy, M.; Gueguen, Y.; Sparfel, L.; Pinel-Marie, M.L.; Boize, M.; Koscielny, S.; Desmots, S.; Pery, A.; Fardel, O.; Alvergnas, M.; Rouleau, A.; Lucchi, G.; Mantion, G.; Heyd, B.; Richert, L.; Ducoroy, P.; Martin, H.; Val, St.; Martinon, L.; Cachier, H.; Yahyaoui, A.; Marfaing, H.; Baeza-Squiban, A.; Martin-Chouly, C.; Bonvallet, M.; Morzadec, C.; Fardel, O.; Vernhet, L.; Baverel, G.; El Hage, M.; Nazaret, R.; Conjard-Duplany, A.; Ferrier, B.; Martin, G.; Legendre, A.; Desmots, S.; Lecomte, A.; Froment, P.; Habert, R.; Lemazurier, E.; Robinel, F.; Dupont, O.; Sanfins, E.; Dairou, J.; Chaffotte, A.F.; Busi, F.; Rodrigues Lima, F.; Dupret, J.M.; Mayati, A.; Le Ferrec, E.; Levoin, N.; Paris, H.; Uriac, Ph.; N'Diaye, M.; Lagadic-Gossmann, D.; Fardel, O.; Assemat, E.; Boublil, L.; Borot, M.C.; Marano, F.; Baeza-Squiban, A.; Martiny, V.Y.; Moroy, G.; Badel, A.; Miteva, M.A.; Hussain, S.; Ferecatu, I.; Borot, C.; Andreau, K.; Baeza-Squiban, A.; Marano, F.; Boland, S.; Leroux, M.; Zucchini-Pascal, N.; Peyre, L.; Rahmani, R.; Buron, N.; Porcedou, M.; Fromenty, B.; Borgne-Sanchez, A.; Rogue, A.; Spire, C.; Claude, N.; Guillouzo, A.

    2010-01-01

    Prevention of possible noxious effects in relation with the exposure to one or several chemical, physical or biological agents present in our domestic or professional environment is one of today's big public health stakes. Another stake is the better assessment of the risks linked with the use of health-care products. The efficacy and predictiveness of toxicology studies are directly related to the combination of alternate complementary methods and animal experiments (obtaining data from different species and with different models: in vitro, ex vivo and in vivo). Despite important efforts, the toxicological evaluation remains perfectible. The proceedings of this 2010 congress of the French Society of cell pharmaco-toxicology deal with recent advances, both scientific and technological, in 'predictive toxicology'. Four main topics are approached: cell and organ models, 'omics', in silico modeling, and new technologies (imaging, cell ships, high-speed processing). Among the different presentations, 3 abstracts present some recent advances in imaging techniques applied to toxicology studies. These are: 1 - first uses in toxicology of TOF-SIMS mass spectroscopy imaging (O. Laprevote, Paris-Descartes Univ. (FR)); 2 - Small animal imaging, a tool for predictive toxicology (A. Le Pape, CNRS Orleans (FR)); 3 - uranium localization at cell level using SIMS imaging technique (C. Rouas et al., IRSN Fontenay-aux-Roses (FR)). (J.S.)

  20. Interdiscursive Character of Semantic Development of Coreferential Metaphors

    Directory of Open Access Journals (Sweden)

    Мансур Фарвазович Гайнаншин

    2016-12-01

    Full Text Available The article is devoted to establishing the character of semantic development involving coreferential metaphors in interdiscursive space. The solution of this problem is aimed at determining semantic relations between different links in chains made up by a number of coreferential metaphors that share the property of variant imagery nomination. The task is implemented within the boundaries of an interdiscourse viewed as a minimum cultural associative context. Empirical data have been drawn from financial and economic texts in electronic and online versions of leading English mass media resources. The meanings of key language units that underlie metaphoric designations of economic notions are clarified with the help of general English language dictionaries and culturological reference books. The analysis of selected examples is carried out based on componential, contextual, discursive, pragmatic analyses and procedures of semantic interpretation supplemented by linguaculturological methods. The investigation allows us to draw the following conclusions: semantic development of coreferential metaphors occurs on two levels: between variant imagery nominations within metaphorical chains M1 + M2 + M3 + ... Мn and between the head metaphor and submetaphors M1 ® ma + mb + mc +... mn; it has proved the role of interdiscursive contextual relations between metaphors having the same type of reference; it has shown the participation of imagery nominations within coreferential chains in the process of sense profiling; it has demonstrated intensification of semantic tension resulting from metaphoric density in coreferential blocks signaling greater synergetic effect produced on the reader.

  1. Historical perspectives on cadmium toxicology

    International Nuclear Information System (INIS)

    Nordberg, Gunnar F.

    2009-01-01

    The first health effects of cadmium (Cd) were reported already in 1858. Respiratory and gastrointestinal symptoms occurred among persons using Cd-containing polishing agent. The first experimental toxicological studies are from 1919. Bone effects and proteinuria in humans were reported in the 1940's. After World War II, a bone disease with fractures and severe pain, the itai-itai disease, a form of Cd-induced renal osteomalacia, was identified in Japan. Subsequently, the toxicokinetics and toxicodynamics of Cd were described including its binding to the protein metallothionein. International warnings of health risks from Cd-pollution were issued in the 1970's. Reproductive and carcinogenic effects were studied at an early stage, but a quantitative assessment of these effects in humans is still subject to considerable uncertainty. The World Health Organization in its International Program on Chemical Safety, WHO/IPCS (1992) (Cadmium. Environmental Health Criteria Document 134, IPCS. WHO, Geneva, 1-280.) identified renal dysfunction as the critical effect and a crude quantitative evaluation was presented. In the 1990's and 2000 several epidemiological studies have reported adverse health effects, sometimes at low environmental exposures to Cd, in population groups in Japan, China, Europe and USA (reviewed in other contributions to the present volume). The early identification of an important role of metallothionein in cadmium toxicology formed the basis for recent studies using biomarkers of susceptibility to development of Cd-related renal dysfunction such as gene expression of metallothionein in peripheral lymphocytes and autoantibodies against metallothionein in blood plasma. Findings in these studies indicate that very low exposure levels to cadmium may give rise to renal dysfunction among sensitive subgroups of human populations such as persons with diabetes.

  2. Semantically Enriching the Search System of a Music Digital Library

    Science.gov (United States)

    de Juan, Paloma; Iglesias, Carlos

    Traditional search systems are usually based on keywords, a very simple and convenient mechanism to express a need for information. This is the most popular way of searching the Web, although it is not always an easy task to accurately summarize a natural language query in a few keywords. Working with keywords means losing the context, which is the only thing that can help us deal with ambiguity. This is the biggest problem of keyword-based systems. Semantic Web technologies seem a perfect solution to this problem, since they make it possible to represent the semantics of a given domain. In this chapter, we present three projects, Harmos, Semusici and Cantiga, whose aim is to provide access to a music digital library. We will describe two search systems, a traditional one and a semantic one, developed in the context of these projects and compare them in terms of usability and effectiveness.

  3. Semantic Annotation of Unstructured Documents Using Concepts Similarity

    Directory of Open Access Journals (Sweden)

    Fernando Pech

    2017-01-01

    Full Text Available There is a large amount of information in the form of unstructured documents which pose challenges in the information storage, search, and retrieval. This situation has given rise to several information search approaches. Some proposals take into account the contextual meaning of the terms specified in the query. Semantic annotation technique can help to retrieve and extract information in unstructured documents. We propose a semantic annotation strategy for unstructured documents as part of a semantic search engine. In this proposal, ontologies are used to determine the context of the entities specified in the query. Our strategy for extracting the context is focused on concepts similarity. Each relevant term of the document is associated with an instance in the ontology. The similarity between each of the explicit relationships is measured through the combination of two types of associations: the association between each pair of concepts and the calculation of the weight of the relationships.

  4. Testing the limits of the semantic illusion phenomenon: ERPs reveal temporary semantic change deafness in discourse comprehension

    NARCIS (Netherlands)

    Nieuwland, M.S.; van Berkum, J.J.A.

    2005-01-01

    In general, language comprehension is surprisingly reliable. Listeners very rapidly extract meaning from the unfolding speech signal, on a word-by-word basis, and usually successfully. Research on ‘semantic illusions’ however suggests that under certain conditions, people fail to notice that the

  5. Psychologizing the Semantics of Fiction

    Directory of Open Access Journals (Sweden)

    John Woods

    2010-04-01

    Full Text Available Psychologiser la sémantique de la fictionLes théoriciens sémantistes de la fiction cherchent typiquement à expliquer nos relations sémantiques au fictionnel dans le contexte plus général des théories de la référence, privilégiant une explication de la sémantique sur le psychologique. Dans cet article, nous défendons une dépendance inverse. Par l’éclaircissement de nos relations psychologiques au fictionnel, nous trouverons un guide pour savoir comment développer une sémantique de la fiction. S’ensuivra une esquisse de la sémantique.Semantic theorists of fiction typically look for an account of our semantic relations to the fictional within general-purpose theories of reference, privileging an explanation of the semantic over the psychological. In this paper, we counsel a reverse dependency. In sorting out our psychological relations to the fictional, there is useful guidance about how to proceed with the semantics of fiction. A sketch of the semantics follows.

  6. Semantic graphs and associative memories

    Science.gov (United States)

    Pomi, Andrés; Mizraji, Eduardo

    2004-12-01

    Graphs have been increasingly utilized in the characterization of complex networks from diverse origins, including different kinds of semantic networks. Human memories are associative and are known to support complex semantic nets; these nets are represented by graphs. However, it is not known how the brain can sustain these semantic graphs. The vision of cognitive brain activities, shown by modern functional imaging techniques, assigns renewed value to classical distributed associative memory models. Here we show that these neural network models, also known as correlation matrix memories, naturally support a graph representation of the stored semantic structure. We demonstrate that the adjacency matrix of this graph of associations is just the memory coded with the standard basis of the concept vector space, and that the spectrum of the graph is a code invariant of the memory. As long as the assumptions of the model remain valid this result provides a practical method to predict and modify the evolution of the cognitive dynamics. Also, it could provide us with a way to comprehend how individual brains that map the external reality, almost surely with different particular vector representations, are nevertheless able to communicate and share a common knowledge of the world. We finish presenting adaptive association graphs, an extension of the model that makes use of the tensor product, which provides a solution to the known problem of branching in semantic nets.

  7. ERPs, semantic processing and age.

    Science.gov (United States)

    Miyamoto, T; Katayama, J; Koyama, T

    1998-06-01

    ERPs (N400, LPC and CNV) were elicited in two sets of subjects grouped according to age (young vs. elderly) using a word-pair category matching paradigm. Each prime consisted of a Japanese noun (constructed from two to four characters of the Hiragana) followed by one Chinese character (Kanji) as the target, this latter representing one of five semantic categories. There were two equally probable target conditions: match or mismatch. Each target was preceded by a prime, either belonging to, or not belonging to, the same semantic category. The subjects were required to respond with a specified button press to the given target according to the condition. We found RTs to be longer in the elderly subjects and under the mismatch condition. N400 amplitude was reduced in the elderly subjects under the mismatch condition and there was no difference between match and mismatch response, which were similar in amplitude to that under match condition for the young subjects. In addition, the CNV amplitudes were larger in the elderly subjects. These results suggested that functional changes in semantic processing through aging (larger semantic networks and diffuse semantic activation) were the cause of this N400 reduction, attributing a subsidiary role to attentional disturbance. We also discuss the importance of taking age-related changes into consideration in clinical studies.

  8. Predictive Toxicology: Current Status and Future Outlook (EBI ...

    Science.gov (United States)

    Slide presentation at the EBI-EMBL Industry Programme Workshop on Predictive Toxicology and the currently status of Computational Toxicology activities at the US EPA. Slide presentation at the EBI-EMBL Industry Programme Workshop on Predictive Toxicology and the currently status of Computational Toxicology activities at the US EPA.

  9. Principles and procedures in forensic toxicology.

    Science.gov (United States)

    Wyman, John F

    2012-09-01

    The principles and procedures employed in a modern forensic toxicology lab are detailed in this review. Aspects of Behavioral and Postmortem toxicology, including certification of analysts and accreditation of labs, chain of custody requirements, typical testing services provided, rationale for specimen selection, and principles of quality assurance are discussed. Interpretation of toxicology results in postmortem specimens requires the toxicologist and pathologist to be cognizant of drug-drug interactions, drug polymorphisms and pharmacogenomics, the gross signs of toxic pathology, postmortem redistribution, confirmation of systemic toxicity in suspected overdoses, the possibility of developed tolerance, and the effects of decomposition on drug concentration.

  10. A Semantic Basis for Meaning Construction in Constructivist Interactions

    Science.gov (United States)

    Badie, Farshad

    2015-01-01

    Regarding constructivism as a learning philosophy and/or a model of knowing, a person (learner or mentor) based on her/his preconceptions and on personal knowings could actively participate in an interaction with another person (learner or mentor) in order to construct her/his personal knowledge. In this research I will analyse "meaning…

  11. Slogans and meanings – a grammatical, semantic and stylistic analysis

    Directory of Open Access Journals (Sweden)

    Marinela Doina NISTEA

    2012-01-01

    Full Text Available According to DEX, explanatory dictionary of the Romanian language, published by the Institute of Linguistics of the Romanian Academy, a slogan is “an eminent, compelling phrasing expressing in a lapidary manner the political or economic aims of groups, organizations, etc., a topical issue” or “a battle cry of old Scottish clans”. Extrapolating, one may say that, nowadays, a product’s slogan is equivalent to the old battle cry: it is defined by concision and memorability, it has a precise purpose and emphasizes the offerer’s personality. Its efficiency for advertising is undeniable. The role of a slogan is to evoke the message in the most focused possible wording, meant to draw the addressee’s attention, even to surprise him/her, getting them to remember the idea suggested, regardless of whether it concerns a certain product offered for sale, or it regards a candidate, a political program or an ideology.

  12. Tattoos: the relationship of diagnostic and semantic meaning.

    Science.gov (United States)

    Romaniuk, A; Tatsenko, N; Smeyanov, V; Movchan, D; Moskalenko, R

    2014-01-01

    This article investigates a tattoo as a component of non-verbal semiotics of medical discourse in pathological anatomy. The purpose is to estimate the diagnostic value of tattoos on the body of patients as semiotic and symbolic aspect of medical communication. Tattoos are classified into three types: image tattoos, feature tattoos, and conventional tattoos (symbolic tattoos). Conventional tattoos are the most informative component of medical discourse symbolics because of their diagnostic value. During the investigation it has been found out that criminal tattoos have the greatest value because of their structuring, clear connection with certain diseases (tuberculosis, liver cirrhosis), and also valuable are tattoos related to drug and alcohol addiction, which are characteristic for patients with viral hepatitis, osteomyelitis.

  13. Filaments of Meaning in Word Space

    OpenAIRE

    Karlgren, Jussi; Holst, Anders; Sahlgren, Magnus

    2008-01-01

    Word space models, in the sense of vector space models built on distributional data taken from texts, are used to model semantic relations between words. We argue that the high dimensionality of typical vector space models lead to unintuitive effects on modeling likeness of meaning and that the local structure of word spaces is where interesting semantic relations reside. We show that the local structure of word spaces has substantially different dimensionality and character than the global s...

  14. Formal Semantics: Origins, Issues, Early Impact

    Directory of Open Access Journals (Sweden)

    Barbara H. Partee

    2010-12-01

    Full Text Available Formal semantics and pragmatics as they have developed since the late 1960's have been shaped by fruitful interdisciplinary collaboration among linguists, philosophers, and logicians, among others, and in turn have had noticeable effects on developments in syntax, philosophy of language, computational linguistics, and cognitive science.In this paper I describe the environment in which formal semantics was born and took root, highlighting the differences in ways of thinking about natural language semantics in linguistics and in philosophy and logic. With Montague as a central but not solo player in the story, I reflect on crucial developments in the 1960's and 70's in linguistics and philosophy, and the growth of formal semantics and formal pragmatics from there. I discuss innovations, key players, and leading ideas that shaped the development of formal semantics and its relation to syntax, to pragmatics, and to the philosophy of language in its early years, and some central aspects of its early impact on those fields.ReferencesAbbott, B. 1999. ‘The formal approach to meaning: Formal semantics and its recent developments’. Journal of Foreign Languages (Shanghai119, no. 1: 2–20. https://www.msu.edu/~abbottb/formal.htm.Ajdukiewicz, K. 1960. Je¸zyk i Poznanie (Language and Knowledge. Warsaw.Bach, E. 1968. ‘Nouns and Noun Phrases’. In E. Bach & R.T. Harms (eds. ‘Universals in Linguistic Theory’, 90–122. NY: Holt, Rinehart & Winston.Bach, E. 1989. Informal Lectures on Formal Semantics. New York: State University of New York Press.Bar-Hillel, Y. 1954a. ‘Logical syntax and semantics’. Language 30: 230–237.http://dx.doi.org/10.2307/410265Bar-Hillel, Y. 1954b. ‘Indexical Expressions’. Mind 63: 359–379.http://dx.doi.org/10.1093/mind/LXIII.251.359Bar-Hillel, Y. 1963. ‘Remarks on Carnap’s Logical Syntax of Language’. In P. A. Schilpp (ed. ‘The Philosophy of Rudolf Carnap’, 519–543. LaSalle, Illinois / London: Open

  15. Compiling Dictionaries Using Semantic Domains*

    Directory of Open Access Journals (Sweden)

    Ronald Moe

    2011-10-01

    Full Text Available

    Abstract: The task of providing dictionaries for all the world's languages is prodigious, re-quiring efficient techniques. The text corpus method cannot be used for minority languages lacking texts. To meet the need, the author has constructed a list of 1 600 semantic domains, which he has successfully used to collect words. In a workshop setting, a group of speakers can collect as many as 17 000 words in ten days. This method results in a classified word list that can be efficiently expanded into a full dictionary. The method works because the mental lexicon is a giant web or-ganized around key concepts. A semantic domain can be defined as an important concept together with the words directly related to it by lexical relations. A person can utilize the mental web to quickly jump from word to word within a domain. The author is developing a template for each domain to aid in collecting words and in de-scribing their semantics. Investigating semantics within the context of a domain yields many in-sights. The method permits the production of both alphabetically and semantically organized dic-tionaries. The list of domains is intended to be universal in scope and applicability. Perhaps due to universals of human experience and universals of linguistic competence, there are striking simi-larities in various lists of semantic domains developed for languages around the world. Using a standardized list of domains to classify multiple dictionaries opens up possibilities for cross-lin-guistic research into semantic and lexical universals.

    Keywords: SEMANTIC DOMAINS, SEMANTIC FIELDS, SEMANTIC CATEGORIES, LEX-ICAL RELATIONS, SEMANTIC PRIMITIVES, DOMAIN TEMPLATES, MENTAL LEXICON, SEMANTIC UNIVERSALS, MINORITY LANGUAGES, LEXICOGRAPHY

    Opsomming: Samestelling van woordeboeke deur gebruikmaking van se-mantiese domeine. Die taak van die voorsiening van woordeboeke aan al die tale van die wêreld is geweldig en vereis doeltreffende tegnieke. Die

  16. Ontology Matching with Semantic Verification.

    Science.gov (United States)

    Jean-Mary, Yves R; Shironoshita, E Patrick; Kabuka, Mansur R

    2009-09-01

    ASMOV (Automated Semantic Matching of Ontologies with Verification) is a novel algorithm that uses lexical and structural characteristics of two ontologies to iteratively calculate a similarity measure between them, derives an alignment, and then verifies it to ensure that it does not contain semantic inconsistencies. In this paper, we describe the ASMOV algorithm, and then present experimental results that measure its accuracy using the OAEI 2008 tests, and that evaluate its use with two different thesauri: WordNet, and the Unified Medical Language System (UMLS). These results show the increased accuracy obtained by combining lexical, structural and extensional matchers with semantic verification, and demonstrate the advantage of using a domain-specific thesaurus for the alignment of specialized ontologies.

  17. The surplus value of semantic annotations

    NARCIS (Netherlands)

    Marx, M.

    2010-01-01

    We compare the costs of semantic annotation of textual documents to its benefits for information processing tasks. Semantic annotation can improve the performance of retrieval tasks and facilitates an improved search experience through faceted search, focused retrieval, better document summaries,

  18. Multiscale Toxicology- Building the Next Generation Tools for Toxicology

    Energy Technology Data Exchange (ETDEWEB)

    Retterer, S. T. [ORNL; Holsapple, M. P. [Battelle Memorial Institute

    2013-10-31

    A Cooperative Research and Development Agreement (CRADA) was established between Battelle Memorial Institute (BMI), Pacific Northwest National Laboratory (PNNL), Oak Ridge National Laboratory (ORNL), Brookhaven National Laboratory (BNL), Lawrence Livermore National Laboratory (LLNL) with the goal of combining the analytical and synthetic strengths of the National Laboratories with BMI's expertise in basic and translational medical research to develop a collaborative pipeline and suite of high throughput and imaging technologies that could be used to provide a more comprehensive understanding of material and drug toxicology in humans. The Multi-Scale Toxicity Initiative (MSTI), consisting of the team members above, was established to coordinate cellular scale, high-throughput in vitro testing, computational modeling and whole animal in vivo toxicology studies between MSTI team members. Development of a common, well-characterized set of materials for testing was identified as a crucial need for the initiative. Two research tracks were established by BMI during the course of the CRADA. The first research track focused on the development of tools and techniques for understanding the toxicity of nanomaterials, specifically inorganic nanoparticles (NPs). ORNL"s work focused primarily on the synthesis, functionalization and characterization of a common set of NPs for dissemination to the participating laboratories. These particles were synthesized to retain the same surface characteristics and size, but to allow visualization using the variety of imaging technologies present across the team. Characterization included the quantitative analysis of physical and chemical properties of the materials as well as the preliminary assessment of NP toxicity using commercially available toxicity screens and emerging optical imaging strategies. Additional efforts examined the development of high-throughput microfluidic and imaging assays for measuring NP uptake, localization, and

  19. The snake as the symbol of medicine, toxicology and toxinology.

    Science.gov (United States)

    Ramoutsaki, I A; Haniotakis, S; Tsatsakis, A M

    2000-10-01

    We investigated the meaning and the roots of the snake's usage as a symbol of medicine, the medical profession, toxicology and toxinology by examining mythological, archeological data and a variety of texts from the ancient Greek world. The snake figure was associated with Asclepios, the ancient Greek God of medicine, and possessed benevolent properties. It was believed to be able to cure a patient or a wounded person just by touch. The snake is also connected with pharmacology and antisepsis, as snakes possess an antivenom against their own poison. The snake is related to sciences associated with poison and death, such as toxicology and toxinology, and it also implies a metaphysical idea. It is connected with the underworld, not only because it crawls on the ground, but because it can bring death, connecting the upper with the underground world. The ability of the snake to shed its skin has been associated with the circle of life, and the renaissance spirit also, ever since early Hellenic antiquity. Consequently, as a symbol of the modern medical profession, toxicology and toxinology, the snake twisted around a stick or the snake beside a pharmapeutic cup, which also implies the use of medicines or even poison, has its roots in the ancient Mediterranean area as proven by the archeological data combined with literary references. Its benevolent as well as its poisonous properties could be paralleled by the similar properties of medicines.

  20. Genetic toxicology in the 21st century: Reflections and future ...

    Science.gov (United States)

    A symposium at the 40th anniversary of the Environmental Mutagen Society, held from October 24–28, 2009 in St. Louis, MO, surveyed the current status and future directions of genetic toxicology. This article summarizes the presentations and provides a perspective on the future. An abbreviated history is presented, highlighting the current standard battery of genotoxicity assays and persistent challenges. Application of computational toxicology to safety testing within a regulatory setting is discussed as a means for reducing the need for animal testing and human clinical trials, and current approaches and applications of in silico genotoxicity screening approaches across the pharmaceutical industry were surveyed and are reported here. The expanded use of toxicogenomics to illuminate mechanisms and bridge genotoxicity and carcinogenicity, and new public efforts to use high-throughput screening technologies to address lack of toxicity evaluation for the backlog of thousands of industrial chemicals in the environment are detailed. The Tox21 project involves coordinated efforts of four U.S. Government regulatory/research entities to use new and innovative assays to characterize key steps in toxicity pathways, including genotoxic and nongenotoxic mechanisms for carcinogenesis. Progress to date, highlighting preliminary test results from the National Toxicology Program is summarized. Finally, an overview is presented of ToxCast™, a related research program of the

  1. Analysis and visualization of disease courses in a semantically-enabled cancer registry.

    Science.gov (United States)

    Esteban-Gil, Angel; Fernández-Breis, Jesualdo Tomás; Boeker, Martin

    2017-09-29

    Regional and epidemiological cancer registries are important for cancer research and the quality management of cancer treatment. Many technological solutions are available to collect and analyse data for cancer registries nowadays. However, the lack of a well-defined common semantic model is a problem when user-defined analyses and data linking to external resources are required. The objectives of this study are: (1) design of a semantic model for local cancer registries; (2) development of a semantically-enabled cancer registry based on this model; and (3) semantic exploitation of the cancer registry for analysing and visualising disease courses. Our proposal is based on our previous results and experience working with semantic technologies. Data stored in a cancer registry database were transformed into RDF employing a process driven by OWL ontologies. The semantic representation of the data was then processed to extract semantic patient profiles, which were exploited by means of SPARQL queries to identify groups of similar patients and to analyse the disease timelines of patients. Based on the requirements analysis, we have produced a draft of an ontology that models the semantics of a local cancer registry in a pragmatic extensible way. We have implemented a Semantic Web platform that allows transforming and storing data from cancer registries in RDF. This platform also permits users to formulate incremental user-defined queries through a graphical user interface. The query results can be displayed in several customisable ways. The complex disease timelines of individual patients can be clearly represented. Different events, e.g. different therapies and disease courses, are presented according to their temporal and causal relations. The presented platform is an example of the parallel development of ontologies and applications that take advantage of semantic web technologies in the medical field. The semantic structure of the representation renders it easy to

  2. Toxicological Evaluation of Lactase Derived from Recombinant Pichia pastoris

    Science.gov (United States)

    Liu, Yifei; Chen, Delong; Luo, Yunbo; Huang, Kunlun; Zhang, Wei; Xu, Wentao

    2014-01-01

    A recombinant lactase was expressed in Pichia pastoris, resulting in enzymatic activity of 3600 U/mL in a 5 L fermenter. The lactase product was subjected to a series of toxicological tests to determine its safety for use as an enzyme preparation in the dairy industry. This recombinant lactase had the highest activity of all recombinant strains reported thus far. Acute oral toxicity, mutagenicity, genotoxic, and subchronic toxicity tests performed in rats and mice showed no death in any groups. The lethal dose 50% (LD50) based on the acute oral toxicity study is greater than 30 mL/kg body weight, which is in accordance with the 1500 L milk consumption of a 50 kg human daily. The lactase showed no mutagenic activity in the Ames test or a mouse sperm abnormality test at levels of up to 5 mg/plate and 1250 mg/kg body weight, respectively. It also showed no genetic toxicology in a bone marrow cell micronucleus test at levels of up to 1250 mg/kg body weight. A 90-day subchronic repeated toxicity study via the diet with lactase levels up to 1646 mg/kg (1000-fold greater than the mean human exposure) did not show any treatment-related significant toxicological effects on body weight, food consumption, organ weights, hematological and clinical chemistry, or histopathology compared to the control groups. This toxicological evaluation system is comprehensive and can be used in the safety evaluation of other enzyme preparations. The lactase showed no acute, mutagenic, genetic, or subchronic toxicity under our evaluation system. PMID:25184300

  3. Toxicological evaluation of lactase derived from recombinant Pichia pastoris.

    Directory of Open Access Journals (Sweden)

    Shiying Zou

    Full Text Available A recombinant lactase was expressed in Pichia pastoris, resulting in enzymatic activity of 3600 U/mL in a 5 L fermenter. The lactase product was subjected to a series of toxicological tests to determine its safety for use as an enzyme preparation in the dairy industry. This recombinant lactase had the highest activity of all recombinant strains reported thus far. Acute oral toxicity, mutagenicity, genotoxic, and subchronic toxicity tests performed in rats and mice showed no death in any groups. The lethal dose 50% (LD50 based on the acute oral toxicity study is greater than 30 mL/kg body weight, which is in accordance with the 1500 L milk consumption of a 50 kg human daily. The lactase showed no mutagenic activity in the Ames test or a mouse sperm abnormality test at levels of up to 5 mg/plate and 1250 mg/kg body weight, respectively. It also showed no genetic toxicology in a bone marrow cell micronucleus test at levels of up to 1250 mg/kg body weight. A 90-day subchronic repeated toxicity study via the diet with lactase levels up to 1646 mg/kg (1000-fold greater than the mean human exposure did not show any treatment-related significant toxicological effects on body weight, food consumption, organ weights, hematological and clinical chemistry, or histopathology compared to the control groups. This toxicological evaluation system is comprehensive and can be used in the safety evaluation of other enzyme preparations. The lactase showed no acute, mutagenic, genetic, or subchronic toxicity under our evaluation system.

  4. Semantic priming effects of synonyms, antonyms, frame, implication and verb-object categories

    Directory of Open Access Journals (Sweden)

    Elsa Skënderi-Rakipllari

    2017-12-01

    Full Text Available Semantic priming has been a major subject of interest for psycholinguists, whose aim is to discover how lexical memory is structured and organized. The facilitation process of word retrieval through semantic priming has long been studied. The present research is aimed to reveal which semantic category has the best priming effect. Through a lexical decision task experiment we compared the reaction times of masked primed pairs and unprimed pairs. In addition, we analyzed the reaction times and priming effect of connected semantic relations: antonymy, frame, synonymy, implication and verb-object. The data collected and interpreted unveiled that the mean reaction times of primed pairs were shorter than those of unprimed pairs. As to semantic priming, the most significantly primed pairs were those of implications and verb- objects, and not those of synonymy or antonymy as it might be expected.

  5. A generalized notion of semantic independence

    DEFF Research Database (Denmark)

    Fränzle, Martin; Stengel, Bernhard von; Wittmüss, Arne

    1995-01-01

    For programs represented semantically as relations, a concept of semantic independence is defined that is more general than previously stated notions. It allows for shared input variables and irrelevant interference due to nondeterminism.......For programs represented semantically as relations, a concept of semantic independence is defined that is more general than previously stated notions. It allows for shared input variables and irrelevant interference due to nondeterminism....

  6. Semantic Indexing of Medical Learning Objects: Medical Students' Usage of a Semantic Network.

    Science.gov (United States)

    Tix, Nadine; Gießler, Paul; Ohnesorge-Radtke, Ursula; Spreckelsen, Cord

    2015-11-11

    The Semantically Annotated Media (SAM) project aims to provide a flexible platform for searching, browsing, and indexing medical learning objects (MLOs) based on a semantic network derived from established classification systems. Primarily, SAM supports the Aachen emedia skills lab, but SAM is ready for indexing distributed content and the Simple Knowledge Organizing System standard provides a means for easily upgrading or even exchanging SAM's semantic network. There is a lack of research addressing the usability of MLO indexes or search portals like SAM and the user behavior with such platforms. The purpose of this study was to assess the usability of SAM by investigating characteristic user behavior of medical students accessing MLOs via SAM. In this study, we chose a mixed-methods approach. Lean usability testing was combined with usability inspection by having the participants complete four typical usage scenarios before filling out a questionnaire. The questionnaire was based on the IsoMetrics usability inventory. Direct user interaction with SAM (mouse clicks and pages accessed) was logged. The study analyzed the typical usage patterns and habits of students using a semantic network for accessing MLOs. Four scenarios capturing characteristics of typical tasks to be solved by using SAM yielded high ratings of usability items and showed good results concerning the consistency of indexing by different users. Long-tail phenomena emerge as they are typical for a collaborative Web 2.0 platform. Suitable but nonetheless rarely used keywords were assigned to MLOs by some users. It is possible to develop a Web-based tool with high usability and acceptance for indexing and retrieval of MLOs. SAM can be applied to indexing multicentered repositories of MLOs collaboratively.

  7. Techniques for Investigating Molecular Toxicology of Nanomaterials.

    Science.gov (United States)

    Wang, Yanli; Li, Chenchen; Yao, Chenjie; Ding, Lin; Lei, Zhendong; Wu, Minghong

    2016-06-01

    Nanotechnology has been a rapidly developing field in the past few decades, resulting in the more and more exposure of nanomaterials to human. The increased applications of nanomaterials for industrial, commercial and life purposes, such as fillers, catalysts, semiconductors, paints, cosmetic additives and drug carriers, have caused both obvious and potential impacts on human health and environment. Nanotoxicology is used to study the safety of nanomaterials and has grown at the historic moment. Molecular toxicology is a new subdiscipline to study the interactions and impacts of materials at the molecular level. To better understand the relationship between the molecular toxicology and nanomaterials, this review summarizes the typical techniques and methods in molecular toxicology which are applied when investigating the toxicology of nanomaterials and include six categories: namely; genetic mutation detection, gene expression analysis, DNA damage detection, chromosomal aberration analysis, proteomics, and metabolomics. Each category involves several experimental techniques and methods.

  8. Space Toxicology: Human Health during Space Operations

    Science.gov (United States)

    Khan-Mayberry, Noreen; James, John T.; Tyl, ROchelle; Lam, Chiu-Wing

    2010-01-01

    Space Toxicology is a unique and targeted discipline for spaceflight, space habitation and occupation of celestial bodies including planets, moons and asteroids. Astronaut explorers face distinctive health challenges and limited resources for rescue and medical care during space operation. A central goal of space toxicology is to protect the health of the astronaut by assessing potential chemical exposures during spaceflight and setting safe limits that will protect the astronaut against chemical exposures, in a physiologically altered state. In order to maintain sustained occupation in space on the International Space Station (ISS), toxicological risks must be assessed and managed within the context of isolation continuous exposures, reuse of air and water, limited rescue options, and the need to use highly toxic compounds for propulsion. As we begin to explore other celestial bodies in situ toxicological risks, such as inhalation of reactive mineral dusts, must also be managed.

  9. Comparative BioInformatics and Computational Toxicology

    Science.gov (United States)

    Reflecting the numerous changes in the field since the publication of the previous edition, this third edition of Developmental Toxicology focuses on the mechanisms of developmental toxicity and incorporates current technologies for testing in the risk assessment process.

  10. Pulmonary toxicology of respirable particles. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, C.L.; Cross, F.T.; Dagle, G.E.; Mahaffey, J.A. (eds.)

    1980-09-01

    Separate abstracts were prepared for the 44 papers presented in these proceedings. The last paper (Stannard) in the proceedings is an historical review of the field of inhalation toxicology and is not included in the analytics. (DS)

  11. Environmental chemistry and toxicology of mercury

    National Research Council Canada - National Science Library

    Liu, Guangliang; Cai, Yong; O'Driscoll, Nelson J

    2012-01-01

    ... employed in recent studies. The coverage discusses the environmental behavior and toxicological effects of mercury on organisms, including humans, and provides case studies at the end of each chapter...

  12. IRIS Toxicological Review of Chloroform (Final Report)

    Science.gov (United States)

    EPA is announcing the release of the final report, Toxicological Review of Chloroform: in support of the Integrated Risk Information System (IRIS). The updated Summary for Chloroform and accompanying Quickview have also been added to the IRIS Database.

  13. Multiscale Toxicology - Building the Next Generation Tools for Toxicology

    Energy Technology Data Exchange (ETDEWEB)

    Thrall, Brian D.; Minard, Kevin R.; Teeguarden, Justin G.; Waters, Katrina M.

    2012-09-01

    A Cooperative Research and Development Agreement (CRADA) was sponsored by Battelle Memorial Institute (Battelle, Columbus), to initiate a collaborative research program across multiple Department of Energy (DOE) National Laboratories aimed at developing a suite of new capabilities for predictive toxicology. Predicting the potential toxicity of emerging classes of engineered nanomaterials was chosen as one of two focusing problems for this program. PNNL’s focus toward this broader goal was to refine and apply experimental and computational tools needed to provide quantitative understanding of nanoparticle dosimetry for in vitro cell culture systems, which is necessary for comparative risk estimates for different nanomaterials or biological systems. Research conducted using lung epithelial and macrophage cell models successfully adapted magnetic particle detection and fluorescent microscopy technologies to quantify uptake of various forms of engineered nanoparticles, and provided experimental constraints and test datasets for benchmark comparison against results obtained using an in vitro computational dosimetry model, termed the ISSD model. The experimental and computational approaches developed were used to demonstrate how cell dosimetry is applied to aid in interpretation of genomic studies of nanoparticle-mediated biological responses in model cell culture systems. The combined experimental and theoretical approach provides a highly quantitative framework for evaluating relationships between biocompatibility of nanoparticles and their physical form in a controlled manner.

  14. Semantic Query Processing : Estimating Relational Purity

    NARCIS (Netherlands)

    Kalo, Jan-Christoph; Lofi, C.; Maseli, René Pascal; Balke, Wolf-Tilo; Leyer, M.

    2017-01-01

    The use of semantic information found in structured knowledge bases has become an integral part of the processing pipeline of modern intelligent in-
    formation systems. However, such semantic information is frequently insuffi-cient to capture the rich semantics demanded by the applications, and

  15. A Model for Semantic IS Standards

    NARCIS (Netherlands)

    Folmer, Erwin Johan Albert; Oude Luttighuis, Paul; van Hillegersberg, Jos

    2011-01-01

    We argue that, in order to suggest improvements of any kind to semantic information system (IS) standards, better understanding of the conceptual structure of semantic IS standard is required. This study develops a model for semantic IS standard, based on literature and expert knowledge. The model

  16. Fluoride in groundwater: toxicological exposure and remedies.

    Science.gov (United States)

    Jha, S K; Singh, R K; Damodaran, T; Mishra, V K; Sharma, D K; Rai, Deepak

    2013-01-01

    Fluoride is a chemical element that is found most frequently in groundwater and has become one of the most important toxicological environmental hazards globally. The occurrence of fluoride in groundwater is due to weathering and leaching of fluoride-bearing minerals from rocks and sediments. Fluoride when ingested in small quantities (dental health by reducing dental caries, whereas higher concentrations (>1.5 mg/L) may cause fluorosis. It is estimated that about 200 million people, from among 25 nations the world over, may suffer from fluorosis and the causes have been ascribed to fluoride contamination in groundwater including India. High fluoride occurrence in groundwaters is expected from sodium bicarbonate-type water, which is calcium deficient. The alkalinity of water also helps in mobilizing fluoride from fluorite (CaF2). Fluoride exposure in humans is related to (1) fluoride concentration in drinking water, (2) duration of consumption, and (3) climate of the area. In hotter climates where water consumption is greater, exposure doses of fluoride need to be modified based on mean fluoride intake. Various cost-effective and simple procedures for water defluoridation techniques are already known, but the benefits of such techniques have not reached the rural affected population due to limitations. Therefore, there is a need to develop workable strategies to provide fluoride-safe drinking water to rural communities. The study investigated the geochemistry and occurrence of fluoride and its contamination in groundwater, human exposure, various adverse health effects, and possible remedial measures from fluoride toxicity effects.

  17. Modern Instrumental Methods in Forensic Toxicology*

    Science.gov (United States)

    Smith, Michael L.; Vorce, Shawn P.; Holler, Justin M.; Shimomura, Eric; Magluilo, Joe; Jacobs, Aaron J.; Huestis, Marilyn A.

    2009-01-01

    This article reviews modern analytical instrumentation in forensic toxicology for identification and quantification of drugs and toxins in biological fluids and tissues. A brief description of the theory and inherent strengths and limitations of each methodology is included. The focus is on new technologies that address current analytical limitations. A goal of this review is to encourage innovations to improve our technological capabilities and to encourage use of these analytical techniques in forensic toxicology practice. PMID:17579968

  18. Integrative Systems Biology Applied to Toxicology

    DEFF Research Database (Denmark)

    Kongsbak, Kristine Grønning

    associated with combined exposure to multiple chemicals. Testing all possible combinations of the tens of thousands environmental chemicals is impractical. This PhD project was launched to apply existing computational systems biology methods to toxicological research. In this thesis, I present in three...... of a system thereby suggesting new ways of thinking specific toxicological endpoints. Furthermore, computational methods can serve as valuable input for the hypothesis generating phase of the preparations of a research project....

  19. Semantic heterogeneity: comparing new semantic web approaches with those of digital libraries

    OpenAIRE

    Krause, Jürgen

    2008-01-01

    To demonstrate that newer developments in the semantic web community, particularly those based on ontologies (simple knowledge organization system and others) mitigate common arguments from the digital library (DL) community against participation in the Semantic web. The approach is a semantic web discussion focusing on the weak structure of the Web and the lack of consideration given to the semantic content during indexing. The points criticised by the semantic web and ontology approaches ar...

  20. Semantic Data Matching: Principles and Performance

    Science.gov (United States)

    Deaton, Russell; Doan, Thao; Schweiger, Tom

    Automated and real-time management of customer relationships requires robust and intelligent data matching across widespread and diverse data sources. Simple string matching algorithms, such as dynamic programming, can handle typographical errors in the data, but are less able to match records that require contextual and experiential knowledge. Latent Semantic Indexing (LSI) (Berry et al. ; Deerwester et al. is a machine intelligence technique that can match data based upon higher order structure, and is able to handle difficult problems, such as words that have different meanings but the same spelling, are synonymous, or have multiple meanings. Essentially, the technique matches records based upon context, or mathematically quantifying when terms occur in the same record.

  1. The Semantic Web in Education

    Science.gov (United States)

    Ohler, Jason

    2008-01-01

    The semantic web or Web 3.0 makes information more meaningful to people by making it more understandable to machines. In this article, the author examines the implications of Web 3.0 for education. The author considers three areas of impact: knowledge construction, personal learning network maintenance, and personal educational administration.…

  2. Quest for a Computerised Semantics.

    Science.gov (United States)

    Leslie, Adrian R.

    The objective of this thesis was to colligate the various strands of research in the literature of computational linguistics that have to do with the computational treatment of semantic content so as to encode it into a computerized dictionary. In chapter 1 the course of mechanical translation (1947-1960) and quantitative linguistics is traced to…

  3. Russian nominal semantics and morphology

    DEFF Research Database (Denmark)

    Nørgård-Sørensen, Jens

    The principal idea behind this book is that lexis and grammar make up a single coherent structure. It is shown that the grammatical patterns of the different classes of Russian nominals are closely interconnected. They can be described as reflecting a limited set of semantic distinctions which ar...... or weaker, of Russian. Students will see a pattern in what is traditionally described as disparate subsystems, and linguists may be inspired to consider the theoretical points concerning language as a coherent system, determining usage.......The principal idea behind this book is that lexis and grammar make up a single coherent structure. It is shown that the grammatical patterns of the different classes of Russian nominals are closely interconnected. They can be described as reflecting a limited set of semantic distinctions which...... are also rooted in the lexical-semantic classification of Russian nouns. The presentation focuses on semantics, both lexical and grammatical, and not least the connection between these two levels of content. The principal theoretical impact is the insight that grammar and lexis should not be seen...

  4. Semantic Reasoning for Scene Interpretation

    DEFF Research Database (Denmark)

    Jensen, Lars Baunegaard With; Baseski, Emre; Pugeault, Nicolas

    2008-01-01

    In this paper, we propose a hierarchical architecture for representing scenes, covering 2D and 3D aspects of visual scenes as well as the semantic relations between the different aspects. We argue that labeled graphs are a suitable representational framework for this representation and demonstrat...

  5. Semantic Enrichment of GPS Trajectories

    NARCIS (Netherlands)

    de Graaff, V.; van Keulen, Maurice; de By, R.A.

    2012-01-01

    Semantic annotation of GPS trajectories helps us to recognize the interests of the creator of the GPS trajectories. Automating this trajectory annotation circumvents the requirement of additional user input. To annotate the GPS traces automatically, two types of automated input are required: 1) a

  6. Semantic Preview Benefit during Reading

    Science.gov (United States)

    Hohenstein, Sven; Kliegl, Reinhold

    2014-01-01

    Word features in parafoveal vision influence eye movements during reading. The question of whether readers extract semantic information from parafoveal words was studied in 3 experiments by using a gaze-contingent display change technique. Subjects read German sentences containing 1 of several preview words that were replaced by a target word…

  7. Semantic search during divergent thinking.

    Science.gov (United States)

    Hass, Richard W

    2017-09-01

    Divergent thinking, as a method of examining creative cognition, has not been adequately analyzed in the context of modern cognitive theories. This article casts divergent thinking responding in the context of theories of memory search. First, it was argued that divergent thinking tasks are similar to semantic fluency tasks, but are more constrained, and less well structured. Next, response time distributions from 54 participants were analyzed for temporal and semantic clustering. Participants responded to two prompts from the alternative uses test: uses for a brick and uses for a bottle, for two minutes each. Participants' cumulative response curves were negatively accelerating, in line with theories of search of associative memory. However, results of analyses of semantic and temporal clustering suggested that clustering is less evident in alternative uses responding compared to semantic fluency tasks. This suggests either that divergent thinking responding does not involve an exhaustive search through a clustered memory trace, but rather that the process is more exploratory, yielding fewer overall responses that tend to drift away from close associates of the divergent thinking prompt. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Clustering semantics for hypermedia presentation

    NARCIS (Netherlands)

    Alberink, M.J.; Rutledge, L.W.; Hardman, H.L.; Veenstra, M.J.A.

    2004-01-01

    Semantic annotations of media repositories make relationships among the stored media and relevant concepts explicit. However, these relationships and the media they join are not directly presentable as hypermedia. Previous work shows how clustering over the annotations in the repositories can

  9. Bare coordination: the semantic shift

    NARCIS (Netherlands)

    de Swart, Henriette; Le Bruyn, Bert

    2014-01-01

    This paper develops an analysis of the syntax-semantics interface of two types of split coordination structures. In the first type, two bare singular count nouns appear as arguments in a coordinated structure, as in bride and groom were happy. We call this the N&N construction. In the second type,

  10. On the universal structure of human lexical semantics.

    Science.gov (United States)

    Youn, Hyejin; Sutton, Logan; Smith, Eric; Moore, Cristopher; Wilkins, Jon F; Maddieson, Ian; Croft, William; Bhattacharya, Tanmoy

    2016-02-16

    How universal is human conceptual structure? The way concepts are organized in the human brain may reflect distinct features of cultural, historical, and environmental background in addition to properties universal to human cognition. Semantics, or meaning expressed through language, provides indirect access to the underlying conceptual structure, but meaning is notoriously difficult to measure, let alone parameterize. Here, we provide an empirical measure of semantic proximity between concepts using cross-linguistic dictionaries to translate words to and from languages carefully selected to be representative of worldwide diversity. These translations reveal cases where a particular language uses a single "polysemous" word to express multiple concepts that another language represents using distinct words. We use the frequency of such polysemies linking two concepts as a measure of their semantic proximity and represent the pattern of these linkages by a weighted network. This network is highly structured: Certain concepts are far more prone to polysemy than others, and naturally interpretable clusters of closely related concepts emerge. Statistical analysis of the polysemies observed in a subset of the basic vocabulary shows that these structural properties are consistent across different language groups, and largely independent of geography, environment, and the presence or absence of a literary tradition. The methods developed here can be applied to any semantic domain to reveal the extent to which its conceptual structure is, similarly, a universal attribute of human cognition and language use.

  11. Assessing semantic similarity of texts - Methods and algorithms

    Science.gov (United States)

    Rozeva, Anna; Zerkova, Silvia

    2017-12-01

    Assessing the semantic similarity of texts is an important part of different text-related applications like educational systems, information retrieval, text summarization, etc. This task is performed by sophisticated analysis, which implements text-mining techniques. Text mining involves several pre-processing steps, which provide for obtaining structured representative model of the documents in a corpus by means of extracting and selecting the features, characterizing their content. Generally the model is vector-based and enables further analysis with knowledge discovery approaches. Algorithms and measures are used for assessing texts at syntactical and semantic level. An important text-mining method and similarity measure is latent semantic analysis (LSA). It provides for reducing the dimensionality of the document vector space and better capturing the text semantics. The mathematical background of LSA for deriving the meaning of the words in a given text by exploring their co-occurrence is examined. The algorithm for obtaining the vector representation of words and their corresponding latent concepts in a reduced multidimensional space as well as similarity calculation are presented.

  12. Does semantic impairment explain surface dyslexia? VLSM evidence for a double dissociation between regularization errors in reading and semantic errors in picture naming

    Directory of Open Access Journals (Sweden)

    Sara Pillay

    2014-04-01

    Full Text Available The correlation between semantic deficits and exception word regularization errors ("surface dyslexia" in semantic dementia has been taken as strong evidence for involvement of semantic codes in exception word pronunciation. Rare cases with semantic deficits but no exception word reading deficit have been explained as due to individual differences in reading strategy, but this account is hotly debated. Semantic dementia is a diffuse process that always includes semantic impairment, making lesion localization difficult and independent assessment of semantic deficits and reading errors impossible. We addressed this problem using voxel-based lesion symptom mapping in 38 patients with left hemisphere stroke. Patients were all right-handed, native English speakers and at least 6 months from stroke onset. Patients performed an oral reading task that included 80 exception words (words with inconsistent orthographic-phonologic correspondence, e.g., pint, plaid, glove. Regularization errors were defined as plausible but incorrect pronunciations based on application of spelling-sound correspondence rules (e.g., 'plaid' pronounced as "played". Two additional tests examined explicit semantic knowledge and retrieval. The first measured semantic substitution errors during naming of 80 standard line drawings of objects. This error type is generally presumed to arise at the level of concept selection. The second test (semantic matching required patients to match a printed sample word (e.g., bus with one of two alternative choice words (e.g., car, taxi on the basis of greater similarity of meaning. Lesions were labeled on high-resolution T1 MRI volumes using a semi-automated segmentation method, followed by diffeomorphic registration to a template. VLSM used an ANCOVA approach to remove variance due to age, education, and total lesion volume. Regularization errors during reading were correlated with damage in the posterior half of the middle temporal gyrus and

  13. [Toxicological evaluation in the childhood].

    Science.gov (United States)

    Arroyo, Amparo; Rodrigo, Carlos; Marrón, M Teresa

    2014-03-01

    Intoxications in infancy require urgent medical treatment within national health systems. In our country they represent 0.3% of paediatric urgencies. Most of them are accidental intoxications but is not infrequent to find some related to child abuse or to suicidal intentions, especially in adolescence. The objectives of the study are to evaluate both clinical health care and medical legal aspects in intoxications in infancy. Medical assistance is described and it includes clinical diagnosis, typology of the more common toxics, percentages and referral to social work and emergency care equipment units of the Ministry of Social Welfare and the Department of Health or, where appropriate, directly to prosecutors and courts for their intervention. In cases of detection of alcohol, drugs or medication in infants, the importance of the correct interpretation of the results of toxicological findings is discussed. Several studies for the interpretation of results concerning the detection of these toxics are reported. Both legal aspects and the forensic medical opinion are assessed. The findings will be analysed by the judicial authority in order to circumscribe responsibilities or to take appropriate decisions concerning the protection of infants' interests. In conclusion intoxication in infancy can lead to legal proceedings requiring specific actions for their protection. Both physicians and hospitals must comply with the legal requirement of the submission to the court of judicial parties. On the other hand, this information is an interesting step toward reinforcing public health surveillance. Copyright © 2014 Elsevier España, S.L. All rights reserved.

  14. Good Practices in Forensic Toxicology.

    Science.gov (United States)

    Drummer, Olaf H

    2017-01-01

    This manuscript provides an overview for analysts, medical and scientific investigators, and laboratory administrators, the range of factors that should be considered to implement best practice forensic toxicology. These include laboratory influence over the collection of specimens, their proper transport and chain-of-custody before arrival in the laboratory. In addition, the laboratory needs to ensure properly trained staff use suitably validated and documented analytical procedures that meet the intended purpose and type of case in an accredited or suitably quality oriented management system. To assist the investigating officers laboratory results require an interpretation over their possible significance when sufficient details are available over the circumstances of the case. This requires a thorough understanding of the various factors that influence concentrations of substances and ultimately their likely physiological effect. These include consideration of the route of ingestion, influence over chronicity of usage on tissue concentrations and tolerance, possible combined drug effects or likely adverse reactions and consideration of relevant genetic factors that may have influenced pharmacokinetic or pharmacodynamic response. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  15. Introduction: biomarkers in neurodevelopment toxicology

    Energy Technology Data Exchange (ETDEWEB)

    Needleman, H.L.

    1987-10-01

    The search for markers of toxicant exposure and effect upon the development of organisms presents a set of challenges that differ in many ways from those encountered in the study of markers in reproduction or pregnancy. These latter two fields specify a relatively narrow set of organs or biological systems. The term development, on the other hand, can apply to any organ system, or to any set of phenomena that changes in an ordered way over time. For this reason the papers presented in the session on development were chosen to narrow the focus to neurodevelopmental markers, as such markers may be altered by neurotoxic exposure. In attempting to meet this task, the authors have been able to select a group of investigators who work at the leading edges of their respective fields of developmental neuroanatomy, neurotoxicology, neuroendocrinology, neuropsychology, and infant development. The notion that toxicants could affect behavior certainly is not new. Recent knowledge that behavioral aberrations can occur at exposures below those which produce organic changes, and that behavioral aberrations can occur at exposures below those which produce organic changes, and that behavioral observation might provide early markers of effect has given rise to two new fields: behavioral toxicology and behavioral teratology.

  16. Action representation: crosstalk between semantics and pragmatics.

    Science.gov (United States)

    Prinz, Wolfgang

    2014-03-01

    Marc Jeannerod pioneered a representational approach to movement and action. In his approach, motor representations provide both, declarative knowledge about action and procedural knowledge for action (action semantics and action pragmatics, respectively). Recent evidence from language comprehension and action simulation supports the claim that action pragmatics and action semantics draw on common representational resources, thus challenging the traditional divide between declarative and procedural action knowledge. To account for these observations, three kinds of theoretical frameworks are discussed: (i) semantics is grounded in pragmatics, (ii) pragmatics is anchored in semantics, and (iii) pragmatics is part and parcel of semantics. © 2013 Elsevier Ltd. All rights reserved.

  17. Semantic Representations in 3D Perceptual Space

    Directory of Open Access Journals (Sweden)

    Suncica Zdravkovic

    2011-05-01

    Full Text Available Barsalou's (1999 perceptual theory of knowledge echoes the pre-20th century tradition of conceptualizing all knowledge as inherently perceptual. Hence conceptual space has an infinite number of dimensions and heavily relies on perceptual experience. Osgood's (1952 semantic differential technique was developed as a bridge between perception and semantics. We updated Osgood's methodology in order to investigate current issues in visual cognition by: (1 using a 2D rather than a 1D space to place the concepts, (2 having dimensions that were perceptual while the targets were conceptual, (3 coupling visual experience with another two perceptual domains (audition and touch, (4 analyzing the data using MDS (not factor analysis. In three experiments, subjects (N = 57 judged five concrete and five abstract words on seven bipolar scales in three perceptual modalities. The 2D space led to different patterns of response compared to the classic 1D space. MDS revealed that perceptual modalities are not equally informative for mapping word-meaning distances (Mantel min = −.23; Mantel max = .88. There was no reliable differences due to test administration modality (paper vs. computer, nor scale orientation. The present findings are consistent with multidimensionality of conceptual space, a perceptual basis for knowledge, and dynamic characteristics of concepts discussed in contemporary theories.

  18. Semantic and phonological coding in poor and normal readers.

    Science.gov (United States)

    Vellutino, F R; Scanlon, D M; Spearing, D

    1995-02-01

    Three studies were conducted evaluating semantic and phonological coding deficits as alternative explanations of reading disability. In the first study, poor and normal readers in second and sixth grade were compared on various tests evaluating semantic development as well as on tests evaluating rapid naming and pseudoword decoding as independent measures of phonological coding ability. In a second study, the same subjects were given verbal memory and visual-verbal learning tasks using high and low meaning words as verbal stimuli and Chinese ideographs as visual stimuli. On the semantic tasks, poor readers performed below the level of the normal readers only at the sixth grade level, but, on the rapid naming and pseudoword learning tasks, they performed below the normal readers at the second as well as at the sixth grade level. On both the verbal memory and visual-verbal learning tasks, performance in poor readers approximated that of normal readers when the word stimuli were high in meaning but not when they were low in meaning. These patterns were essentially replicated in a third study that used some of the same semantic and phonological measures used in the first experiment, and verbal memory and visual-verbal learning tasks that employed word lists and visual stimuli (novel alphabetic characters) that more closely approximated those used in learning to read. It was concluded that semantic coding deficits are an unlikely cause of reading difficulties in most poor readers at the beginning stages of reading skills acquisition, but accrue as a consequence of prolonged reading difficulties in older readers. It was also concluded that phonological coding deficits are a probable cause of reading difficulties in most poor readers.

  19. Data governance in predictive toxicology: A review.

    Science.gov (United States)

    Fu, Xin; Wojak, Anna; Neagu, Daniel; Ridley, Mick; Travis, Kim

    2011-07-13

    Due to recent advances in data storage and sharing for further data processing in predictive toxicology, there is an increasing need for flexible data representations, secure and consistent data curation and automated data quality checking. Toxicity prediction involves multidisciplinary data. There are hundreds of collections of chemical, biological and toxicological data that are widely dispersed, mostly in the open literature, professional research bodies and commercial companies. In order to better manage and make full use of such large amount of toxicity data, there is a trend to develop functionalities aiming towards data governance in predictive toxicology to formalise a set of processes to guarantee high data quality and better data management. In this paper, data quality mainly refers in a data storage sense (e.g. accuracy, completeness and integrity) and not in a toxicological sense (e.g. the quality of experimental results). This paper reviews seven widely used predictive toxicology data sources and applications, with a particular focus on their data governance aspects, including: data accuracy, data completeness, data integrity, metadata and its management, data availability and data authorisation. This review reveals the current problems (e.g. lack of systematic and standard measures of data quality) and desirable needs (e.g. better management and further use of captured metadata and the development of flexible multi-level user access authorisation schemas) of predictive toxicology data sources development. The analytical results will help to address a significant gap in toxicology data quality assessment and lead to the development of novel frameworks for predictive toxicology data and model governance. While the discussed public data sources are well developed, there nevertheless remain some gaps in the development of a data governance framework to support predictive toxicology. In this paper, data governance is identified as the new challenge in

  20. Data governance in predictive toxicology: A review

    Directory of Open Access Journals (Sweden)

    Fu Xin

    2011-07-01

    Full Text Available Abstract Background Due to recent advances in data storage and sharing for further data processing in predictive toxicology, there is an increasing need for flexible data representations, secure and consistent data curation and automated data quality checking. Toxicity prediction involves multidisciplinary data. There are hundreds of collections of chemical, biological and toxicological data that are widely dispersed, mostly in the open literature, professional research bodies and commercial companies. In order to better manage and make full use of such large amount of toxicity data, there is a trend to develop functionalities aiming towards data governance in predictive toxicology to formalise a set of processes to guarantee high data quality and better data management. In this paper, data quality mainly refers in a data storage sense (e.g. accuracy, completeness and integrity and not in a toxicological sense (e.g. the quality of experimental results. Results This paper reviews seven widely used predictive toxicology data sources and applications, with a particular focus on their data governance aspects, including: data accuracy, data completeness, data integrity, metadata and its management, data availability and data authorisation. This review reveals the current problems (e.g. lack of systematic and standard measures of data quality and desirable needs (e.g. better management and further use of captured metadata and the development of flexible multi-level user access authorisation schemas of predictive toxicology data sources development. The analytical results will help to address a significant gap in toxicology data quality assessment and lead to the development of novel frameworks for predictive toxicology data and model governance. Conclusions While the discussed public data sources are well developed, there nevertheless remain some gaps in the development of a data governance framework to support predictive toxicology. In this paper

  1. A Denotational Semantics for Communicating Unstructured Code

    Directory of Open Access Journals (Sweden)

    Nils Jähnig

    2015-03-01

    Full Text Available An important property of programming language semantics is that they should be compositional. However, unstructured low-level code contains goto-like commands making it hard to define a semantics that is compositional. In this paper, we follow the ideas of Saabas and Uustalu to structure low-level code. This gives us the possibility to define a compositional denotational semantics based on least fixed points to allow for the use of inductive verification methods. We capture the semantics of communication using finite traces similar to the denotations of CSP. In addition, we examine properties of this semantics and give an example that demonstrates reasoning about communication and jumps. With this semantics, we lay the foundations for a proof calculus that captures both, the semantics of unstructured low-level code and communication.

  2. A Semantics for Distributed Execution of Statemate

    DEFF Research Database (Denmark)

    Fränzle, Martin; Niehaus, Jürgen; Metzner, Alexander

    2003-01-01

    We present a semantics for the statechart variant implemented in the Statemate product of i-Logix. Our semantics enables distributed code generation for Statemate models in the context of rapid prototyping for embedded control applications. We argue that it seems impossible to efficiently generate......, the changes made regarding the interaction of distributed model parts are similar to the interaction between the model and its environment in the original semantics, thus giving designers a familiar execution model. The semantics has been implemented in Grace, a framework for rapid prototyping code generation...... distributed code using the original Statemate semantics. The new, distributed semantics has the advantages that, first, it enables the generation of efficient distributed code, second, it preserves many aspects of the original semantics for those parts of a model that are not distributed, and third...

  3. Occupational risk and toxicology evaluations of industrial water conditioning.

    Science.gov (United States)

    Broussard, G; Bramanti, O; Marchese, F M

    1997-08-01

    This study addresses the chemical and toxicological questions due to the wide use of chemical treatment programmes for industrial cooling water. First, natural problems encountered in cooling tower systems were presented and grouped into three categories: (i) scaling; (ii) corrosion and (iii) biofouling. Chemical solutions adopted in industrial plants were outlined for each one in order to minimize damage and categorized as shut-down, production loss, heat transfer reduction, upsets, etc. Above all, the purpose of the work was to identify the most dangerous chemicals normally used, which means sources of chemical risk for safety workers and their environment; thus, symptoms of exposure, prevention measures and protection tools are also described.

  4. Precision toxicology based on single cell sequencing: an evolving trend in toxicological evaluations and mechanism exploration.

    Science.gov (United States)

    Zhang, Boyang; Huang, Kunlun; Zhu, Liye; Luo, Yunbo; Xu, Wentao

    2017-07-01

    In this review, we introduce a new concept, precision toxicology: the mode of action of chemical- or drug-induced toxicity can be sensitively and specifically investigated by isolating a small group of cells or even a single cell with typical phenotype of interest followed by a single cell sequencing-based analysis. Precision toxicology can contribute to the better detection of subtle intracellular changes in response to exogenous substrates, and thus help researchers find solutions to control or relieve the toxicological effects that are serious threats to human health. We give examples for single cell isolation and recommend laser capture microdissection for in vivo studies and flow cytometric sorting for in vitro studies. In addition, we introduce the procedures for single cell sequencing and describe the expected application of these techniques to toxicological evaluations and mechanism exploration, which we believe will become a trend in toxicology.

  5. Non-precautionary aspects of toxicology

    International Nuclear Information System (INIS)

    Grandjean, Philippe

    2005-01-01

    Empirical studies in toxicology aim at deciphering complex causal relationships, especially in regard to human disease etiologies. Several scientific traditions limit the usefulness of documentation from current toxicological research, in regard to decision-making based on the precautionary principle. Among non-precautionary aspects of toxicology are the focus on simplified model systems and the effects of single hazards, one by one. Thus, less attention is paid to sources of variability and uncertainty, including individual susceptibility, impacts of mixed and variable exposures, susceptible life-stages, and vulnerable communities. In emphasizing the need for confirmatory evidence, toxicology tends to penalize false positives more than false negatives. An important source of uncertainty is measurement error that results in misclassification, especially in regard to exposure assessment. Standard statistical analysis assumes that the exposure is measured without error, and imprecisions will usually result in an underestimation of the dose-effect relationship. In testing whether an effect could be considered a possible result of natural variability, a 5% limit for 'statistical significance' is usually applied, even though it may rule out many findings of causal associations, simply because the study was too small (and thus lacked statistical power) or because some imprecision or limited sensitivity of the parameters precluded a more definitive observation. These limitations may be aggravated when toxicology is influenced by vested interests. Because current toxicology overlooks the important goal of achieving a better characterization of uncertainties and their implications, research approaches should be revised and strengthened to counteract the innate ideological biases, thereby supporting our confidence in using toxicology as a main source of documentation and in using the precautionary principle as a decision procedure in the public policy arena

  6. MORPHOLOGICAL REPRESENTATION AND SEMANTIC ...

    African Journals Online (AJOL)

    The present paper deals with the question of whether the Compositionality. Condition can be ... Selkirk's rule for assigning grammatical functions to the nonhead of .... the meaning of Godel numbering is strictly compositional, a simple ... ennoble, encase), and (ii) nouns of the form V P which are headless ..... *v --> her Prt.

  7. A semantic web framework to integrate cancer omics data with biological knowledge.

    Science.gov (United States)

    Holford, Matthew E; McCusker, James P; Cheung, Kei-Hoi; Krauthammer, Michael

    2012-01-25

    The RDF triple provides a simple linguistic means of describing limitless types of information. Triples can be flexibly combined into a unified data source we call a semantic model. Semantic models open new possibilities for the integration of variegated biological data. We use Semantic Web technology to explicate high throughput clinical data in the context of fundamental biological knowledge. We have extended Corvus, a data warehouse which provides a uniform interface to various forms of Omics data, by providing a SPARQL endpoint. With the querying and reasoning tools made possible by the Semantic Web, we were able to explore quantitative semantic models retrieved from Corvus in the light of systematic biological knowledge. For this paper, we merged semantic models containing genomic, transcriptomic and epigenomic data from melanoma samples with two semantic models of functional data - one containing Gene Ontology (GO) data, the other, regulatory networks constructed from transcription factor binding information. These two semantic models were created in an ad hoc manner but support a common interface for integration with the quantitative semantic models. Such combined semantic models allow us to pose significant translational medicine questions. Here, we study the interplay between a cell's molecular state and its response to anti-cancer therapy by exploring the resistance of cancer cells to Decitabine, a demethylating agent. We were able to generate a testable hypothesis to explain how Decitabine fights cancer - namely, that it targets apoptosis-related gene promoters predominantly in Decitabine-sensitive cell lines, thus conveying its cytotoxic effect by activating the apoptosis pathway. Our research provides a framework whereby similar hypotheses can be developed easily.

  8. The absoluteness of semantic processing: lessons from the analysis of temporal clusters in phonemic verbal fluency.

    Directory of Open Access Journals (Sweden)

    Isabelle Vonberg

    Full Text Available For word production, we may consciously pursue semantic or phonological search strategies, but it is uncertain whether we can retrieve the different aspects of lexical information independently from each other. We therefore studied the spread of semantic information into words produced under exclusively phonemic task demands.42 subjects participated in a letter verbal fluency task, demanding the production of as many s-words as possible in two minutes. Based on curve fittings for the time courses of word production, output spurts (temporal clusters considered to reflect rapid lexical retrieval based on automatic activation spread, were identified. Semantic and phonemic word relatedness within versus between these clusters was assessed by respective scores (0 meaning no relation, 4 maximum relation.Subjects produced 27.5 (±9.4 words belonging to 6.7 (±2.4 clusters. Both phonemically and semantically words were more related within clusters than between clusters (phon: 0.33±0.22 vs. 0.19±0.17, p<.01; sem: 0.65±0.29 vs. 0.37±0.29, p<.01. Whereas the extent of phonemic relatedness correlated with high task performance, the contrary was the case for the extent of semantic relatedness.The results indicate that semantic information spread occurs, even if the consciously pursued word search strategy is purely phonological. This, together with the negative correlation between semantic relatedness and verbal output suits the idea of a semantic default mode of lexical search, acting against rapid task performance in the given scenario of phonemic verbal fluency. The simultaneity of enhanced semantic and phonemic word relatedness within the same temporal cluster boundaries suggests an interaction between content and sound-related information whenever a new semantic field has been opened.

  9. Life, Information, Entropy, and Time: Vehicles for Semantic Inheritance.

    Science.gov (United States)

    Crofts, Antony R

    2007-01-01

    Attempts to understand how information content can be included in an accounting of the energy flux of the biosphere have led to the conclusion that, in information transmission, one component, the semantic content, or "the meaning of the message," adds no thermodynamic burden over and above costs arising from coding, transmission and translation. In biology, semantic content has two major roles. For all life forms, the message of the genotype encoded in DNA specifies the phenotype, and hence the organism that is tested against the real world through the mechanisms of Darwinian evolution. For human beings, communication through language and similar abstractions provides an additional supra-phenotypic vehicle for semantic inheritance, which supports the cultural heritages around which civilizations revolve. The following three postulates provide the basis for discussion of a number of themes that demonstrate some important consequences. (i) Information transmission through either pathway has thermodynamic components associated with data storage and transmission. (ii) The semantic content adds no additional thermodynamic cost. (iii) For all semantic exchange, meaning is accessible only through translation and interpretation, and has a value only in context. (1) For both pathways of semantic inheritance, translational and copying machineries are imperfect. As a consequence both pathways are subject to mutation and to evolutionary pressure by selection. Recognition of semantic content as a common component allows an understanding of the relationship between genes and memes, and a reformulation of Universal Darwinism. (2) The emergent properties of life are dependent on a processing of semantic content. The translational steps allow amplification in complexity through combinatorial possibilities in space and time. Amplification depends on the increased potential for complexity opened by 3D interaction specificity of proteins, and on the selection of useful variants by

  10. IRIS TOXICOLOGICAL REVIEW AND SUMMARY ...

    Science.gov (United States)

    The Draft Toxicological Review was developed to evaluate both the cancer and non cancer human health risks from environmental exposure to vinyl chloride. A reference concentration (RfC), and a reference dose (RfD) were developed based upon induction of liver cell polymorphism in a chronic dietary study utilizing Wistar rats. An RfC of 1E-1 mg/m3 and an RfD of 5E-3 mg/kg-d are recommended. On the basis of sufficient evidence for carcinogenicity in human epidemiology studies vinyl chloride is reaffirmed to be a known human carcinogen. Cancer potencies were derived for oral and inhalation exposure. An oral slope factor of 1.3 per (mg/kg-day) for continuous exposure during adulthood and 2.5 per (mg/kg-day) for continuous lifetime exposure from birth, based upon a chronic dietary study in female Wistar rats is recommended; an inhalation unit risk of 4.3 E-6 per (55g/m3) for continuous exposure during adulthood and 8.7 E-6 per (55g/m3) for continuous lifetime exposure from birth is also recommended, based upon exposure of male and female Sprague Dawley rats and Swiss mice, via inhalation, for a lifetime. A PBPK model was used in the derivation of the RfC, RfD, and cancer potency estimates. Its use is based on the assumption that equal tissue concentrations of reactive metabolite, chlorethylene oxide or chloracetaldehyde, at the critical target site will result in equivalent toxicity between species.

  11. Exploiting semantic linkages among multiple sources for semantic information retrieval

    Science.gov (United States)

    Li, JianQiang; Yang, Ji-Jiang; Liu, Chunchen; Zhao, Yu; Liu, Bo; Shi, Yuliang

    2014-07-01

    The vision of the Semantic Web is to build a global Web of machine-readable data to be consumed by intelligent applications. As the first step to make this vision come true, the initiative of linked open data has fostered many novel applications aimed at improving data accessibility in the public Web. Comparably, the enterprise environment is so different from the public Web that most potentially usable business information originates in an unstructured form (typically in free text), which poses a challenge for the adoption of semantic technologies in the enterprise environment. Considering that the business information in a company is highly specific and centred around a set of commonly used concepts, this paper describes a pilot study to migrate the concept of linked data into the development of a domain-specific application, i.e. the vehicle repair support system. The set of commonly used concepts, including the part name of a car and the phenomenon term on the car repairing, are employed to build the linkage between data and documents distributed among different sources, leading to the fusion of documents and data across source boundaries. Then, we describe the approaches of semantic information retrieval to consume these linkages for value creation for companies. The experiments on two real-world data sets show that the proposed approaches outperform the best baseline 6.3-10.8% and 6.4-11.1% in terms of top five and top 10 precisions, respectively. We believe that our pilot study can serve as an important reference for the development of similar semantic applications in an enterprise environment.

  12. Information adaptation the interplay between Shannon information and semantic information in cognition

    CERN Document Server

    Haken, Hermann

    2015-01-01

    This monograph demonstrates the interplay between Shannon information and semantic information in cognition. It shows that Shannon’s information acts as driving force for the formation of semantic information; and vice versa, namely, that semantic information participates in the formation of Shannonian information. The authors show that in cognition, Shannonian and semantic information are interrelated as two aspects of a cognitive process termed as information adaptation. In the latter the mind/brain adapts to the environment by the deflating and/or inflating of the information conveyed by the environment. In the process of information adaptation, quantitative variations in Shannon’s information entail different meanings while different meanings affect the quantity of information. The book illustrates the above conceptually and mathematically by reference to three cognitive processes: pattern recognition, face learning and the recognition of a moving object.

  13. Semantic analyzability in children's understanding of idioms.

    Science.gov (United States)

    Gibbs, R W

    1991-06-01

    This study investigated the role of semantic analyzability in children's understanding of idioms. Kindergartners and first, third, and fourth graders listened to idiomatic expressions either alone or at the end of short story contexts. Their task was to explain verbally the intended meanings of these phrases and then to choose their correct idiomatic interpretations. The idioms presented to the children differed in their degree of analyzability. Some idioms were highly analyzable or decomposable, with the meanings of their parts contributing independently to their overall figurative meanings. Other idioms were nondecomposable because it was difficult to see any relation between a phrase's individual components and the idiom's figurative meaning. The results showed that younger children (kindergartners and first graders) understood decomposable idioms better than they did nondecomposable phrases. Older children (third and fourth graders) understood both kinds of idioms equally well in supporting contexts, but were better at interpreting decomposable idioms than they were at understanding nondecomposable idioms without contextual information. These findings demonstrate that young children better understand idiomatic phrases whose individual parts independently contribute to their overall figurative meanings.

  14. Efficient Mobile Client Caching Supporting Transaction Semantics

    Directory of Open Access Journals (Sweden)

    IlYoung Chung

    2000-05-01

    Full Text Available In mobile client-server database systems, caching of frequently accessed data is an important technique that will reduce the contention on the narrow bandwidth wireless channel. As the server in mobile environments may not have any information about the state of its clients' cache(stateless server, using broadcasting approach to transmit the updated data lists to numerous concurrent mobile clients is an attractive approach. In this paper, a caching policy is proposed to maintain cache consistency for mobile computers. The proposed protocol adopts asynchronous(non-periodic broadcasting as the cache invalidation scheme, and supports transaction semantics in mobile environments. With the asynchronous broadcasting approach, the proposed protocol can improve the throughput by reducing the abortion of transactions with low communication costs. We study the performance of the protocol by means of simulation experiments.

  15. Semantics and artificial intelligence in machine translation

    Energy Technology Data Exchange (ETDEWEB)

    King, M

    1981-01-01

    The author exemplifies three types of ambiguity that the introduction of semantics or of AI methods might be expected to solve: word sense, structural, and referential ambiguity. From this point of view she examines the works of Schank, Riesbeck, Minsky, Charniak, and Wilks, and she comes to the conclusion that the systems described will not be of much help for the development of operational MT-systems, except within a well-defined, constrained world. The latter aspect is illustrated by the author by means of a description of the Edinburgh Mecho-project. But, as the vast majority of texts destined for MT does not come from a constrained world, such systems will hardly be used as MT production systems. Still, MT-systems like Eurotra give the chance of making intelligent use of AI ideas. 16 references.

  16. Long-term interference at the semantic level: Evidence from blocked-cyclic picture matching.

    Science.gov (United States)

    Wei, Tao; Schnur, Tatiana T

    2016-01-01

    Processing semantically related stimuli creates interference across various domains of cognition, including language and memory. In this study, we identify the locus and mechanism of interference when retrieving meanings associated with words and pictures. Subjects matched a probe stimulus (e.g., cat) to its associated target picture (e.g., yarn) from an array of unrelated pictures. Across trials, probes were either semantically related or unrelated. To test the locus of interference, we presented probes as either words or pictures. If semantic interference occurs at the stage common to both tasks, that is, access to semantic representations, then interference should occur in both probe presentation modalities. Results showed clear semantic interference effects independent of presentation modality and lexical frequency, confirming a semantic locus of interference in comprehension. To test the mechanism of interference, we repeated trials across 4 presentation cycles and manipulated the number of unrelated intervening trials (zero vs. two). We found that semantic interference was additive across cycles and survived 2 intervening trials, demonstrating interference to be long-lasting as opposed to short-lived. However, interference was smaller with zero versus 2 intervening trials, which we interpret to suggest that short-lived facilitation counteracted the long-lived interference. We propose that retrieving meanings associated with words/pictures from the same semantic category yields both interference due to long-lasting changes in connection strength between semantic representations (i.e., incremental learning) and facilitation caused by short-lived residual activation. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  17. Accelerating cancer systems biology research through Semantic Web technology.

    Science.gov (United States)

    Wang, Zhihui; Sagotsky, Jonathan; Taylor, Thomas; Shironoshita, Patrick; Deisboeck, Thomas S

    2013-01-01

    Cancer systems biology is an interdisciplinary, rapidly expanding research field in which collaborations are a critical means to advance the field. Yet the prevalent database technologies often isolate data rather than making it easily accessible. The Semantic Web has the potential to help facilitate web-based collaborative cancer research by presenting data in a manner that is self-descriptive, human and machine readable, and easily sharable. We have created a semantically linked online Digital Model Repository (DMR) for storing, managing, executing, annotating, and sharing computational cancer models. Within the DMR, distributed, multidisciplinary, and inter-organizational teams can collaborate on projects, without forfeiting intellectual property. This is achieved by the introduction of a new stakeholder to the collaboration workflow, the institutional licensing officer, part of the Technology Transfer Office. Furthermore, the DMR has achieved silver level compatibility with the National Cancer Institute's caBIG, so users can interact with the DMR not only through a web browser but also through a semantically annotated and secure web service. We also discuss the technology behind the DMR leveraging the Semantic Web, ontologies, and grid computing to provide secure inter-institutional collaboration on cancer modeling projects, online grid-based execution of shared models, and the collaboration workflow protecting researchers' intellectual property. Copyright © 2012 Wiley Periodicals, Inc.

  18. Semantic relations differentially impact associative recognition memory: electrophysiological evidence.

    Science.gov (United States)

    Kriukova, Olga; Bridger, Emma; Mecklinger, Axel

    2013-10-01

    Though associative recognition memory is thought to rely primarily on recollection, recent research indicates that familiarity might also make a substantial contribution when to-be-learned items are integrated into a coherent structure by means of an existing semantic relation. It remains unclear how different types of semantic relations, such as categorical (e.g., dancer-singer) and thematic (e.g., dancer-stage) relations might affect associative recognition, however. Using event-related potentials (ERPs), we addressed this question by manipulating the type of semantic link between paired words in an associative recognition memory experiment. An early midfrontal old/new effect, typically linked to familiarity, was observed across the relation types. In contrast, a robust left parietal old/new effect was found in the categorical condition only, suggesting a clear contribution of recollection to associative recognition for this kind of pairs. One interpretation of this pattern is that familiarity was sufficiently diagnostic for associative recognition of thematic relations, which could result from the integrative nature of the thematic relatedness compared to the similarity-based nature of categorical pairs. The present study suggests that the extent to which recollection and familiarity are involved in associative recognition is at least in part determined by the properties of semantic relations between the paired associates. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. Context effects in embodied lexical-semantic processing

    Directory of Open Access Journals (Sweden)

    Wessel O Van Dam

    2010-10-01

    Full Text Available The embodied view of language comprehension proposes that the meaning of words is grounded in perception and action rather than represented in abstract amodal symbols. Support for embodied theories of language processing comes from behavioural studies showing that understanding a sentence about an action can modulate congruent and incongruent physical responses, suggesting motor involvement during comprehension of sentences referring to bodily movement. Additionally, several neuroimaging studies have provided evidence that comprehending single words denoting manipulable objects elicits specific responses in the neural motor system. An interesting question that remains is whether action semantic knowledge is directly activated as motor simulations in the brain, or rather modulated by the semantic context in which action words are encountered. In the current paper we investigated the nature of conceptual representations using a go/no-go lexical decision task. Specifically, target words were either presented in a semantic context that emphasized dominant action features (features related to the functional use of an object or non-dominant action features. The response latencies in a lexical decision task reveal that participants were faster to respond to words denoting objects for which the functional use was congruent with the prepared movement. This facilitation effect, however, was only apparent when the semantic context emphasized corresponding motor properties. These findings suggest that motor involvement during comprehension of sentences is not automatic. Rather, the results suggest that conceptual processing is a context-dependent process that incorporates motor-related knowledge in a flexible manner.

  20. A Postcolonial Semantics of Personhood

    DEFF Research Database (Denmark)

    Levisen, Carsten

    that provide an answer to the question: “what makes up a person?” The paper aims toarticulate semantic explications and cultural scripts for personhood constructs in Bislama, beingmindful of the anglicizations, contradictions, and reinventions that are characteristic of postcolonialdiscourse......, 2013-2015 (Levisen 2016a, 2016b). I willfocus on the keyword tingting ‘mind, heart’ (from English ‘think-think’), and the related concepts speret(from English ‘spirit’), devil (from English ‘devil’), and pija (from English ‘picture’), as well as morerecent imports from English: maen (mind), sol (soul...... levels. Traditionalterms like devil and pija are being problematized by urban speakers, and are both in decline. Sol,maen, and had have become more common, and speret/spirit has undergone a semanticanglicization. Tingting remains the key construct, around which Bislama personhood semantics isorganized...

  1. Learning for Semantic Parsing with Kernels under Various Forms of Supervision

    Science.gov (United States)

    2007-08-01

    natural language sentences to their formal executable meaning representations. This is a challenging problem and is critical for developing computing...sentences are semantically tractable. This indi- cates that Geoquery is more challenging domain for semantic parsing than ATIS. In the past, there have been a...Combining parsers. In Proceedings of the Conference on Em- pirical Methods in Natural Language Processing and Very Large Corpora (EMNLP/ VLC -99), pp. 187–194

  2. Weak negation in inquisitive semantics

    Czech Academy of Sciences Publication Activity Database

    Punčochář, Vít

    2015-01-01

    Roč. 24, č. 3 (2015), s. 323-355 ISSN 0925-8531 R&D Projects: GA ČR(CZ) GA13-21076S Institutional support: RVO:67985955 Keywords : inquisitive semantics * negation * possible worlds * Fitch-style natural deduction * denial Subject RIV: AA - Philosophy ; Religion Impact factor: 0.450, year: 2015 http://link.springer.com/article/10.1007%2Fs10849-015-9219-2

  3. ACToR - Aggregated Computational Toxicology Resource

    International Nuclear Information System (INIS)

    Judson, Richard; Richard, Ann; Dix, David; Houck, Keith; Elloumi, Fathi; Martin, Matthew; Cathey, Tommy; Transue, Thomas R.; Spencer, Richard; Wolf, Maritja

    2008-01-01

    ACToR (Aggregated Computational Toxicology Resource) is a database and set of software applications that bring into one central location many types and sources of data on environmental chemicals. Currently, the ACToR chemical database contains information on chemical structure, in vitro bioassays and in vivo toxicology assays derived from more than 150 sources including the U.S. Environmental Protection Agency (EPA), Centers for Disease Control (CDC), U.S. Food and Drug Administration (FDA), National Institutes of Health (NIH), state agencies, corresponding government agencies in Canada, Europe and Japan, universities, the World Health Organization (WHO) and non-governmental organizations (NGOs). At the EPA National Center for Computational Toxicology, ACToR helps manage large data sets being used in a high-throughput environmental chemical screening and prioritization program called ToxCast TM

  4. Toxicology research projects directory, 1978. Monthly repts

    International Nuclear Information System (INIS)

    1978-01-01

    The Toxicology Research Projects Directory is a monthly publication of ongoing research projects in toxicology and related fields selected from the files of the Smithsonian Science Information Exchange (SSIE). Each issue lists toxicology-related research projects reported to SSIE during the one-month period preceding that issue. Each of the summaries is categorized by scientific discipline and assigned a unique identification number for cross-referencing from the Directory Indexes--Subject, Investigator, Performing Organization, Supporting Agency, and Master Grant Number. The thirteenth issue consists of Cumulative Indexes for the entire volume with referencing to projects in all of the previous twelve issues. The emphasis of the Directory is on the manifestations of the exposure of man and animals to toxic substances. Projects are classified by toxic agents, research orientation, and areas of environmental concern

  5. Prospects for applying synthetic biology to toxicology

    DEFF Research Database (Denmark)

    Behrendorff, James Bruce Yarnton H; Gillam, Elizabeth M.J.

    2017-01-01

    The 30 years since the inception of Chemical Research in Toxicology, game-changing advances in chemical and molecular biology, the fundamental disciplines underpinning molecular toxicology, have been made. While these have led to important advances in the study of mechanisms by which chemicals...... damage cells and systems, there has been less focus on applying these advances to prediction, detection, and mitigation of toxicity. Over the last ∼15 years, synthetic biology, the repurposing of biological "parts" in systems engineered for useful ends, has been explored in other areas of the biomedical...... and life sciences, for such applications as detecting metabolites, drug discovery and delivery, investigating disease mechanisms, improving medical treatment, and producing useful chemicals. These examples provide models for the application of synthetic biology to toxicology, which, for the most part, has...

  6. Semantic Memory in the Clinical Progression of Alzheimer Disease.

    Science.gov (United States)

    Tchakoute, Christophe T; Sainani, Kristin L; Henderson, Victor W

    2017-09-01

    Semantic memory measures may be useful in tracking and predicting progression of Alzheimer disease. We investigated relationships among semantic memory tasks and their 1-year predictive value in women with Alzheimer disease. We conducted secondary analyses of a randomized clinical trial of raloxifene in 42 women with late-onset mild-to-moderate Alzheimer disease. We assessed semantic memory with tests of oral confrontation naming, category fluency, semantic recognition and semantic naming, and semantic density in written narrative discourse. We measured global cognition (Alzheimer Disease Assessment Scale, cognitive subscale), dementia severity (Clinical Dementia Rating sum of boxes), and daily function (Activities of Daily Living Inventory) at baseline and 1 year. At baseline and 1 year, most semantic memory scores correlated highly or moderately with each other and with global cognition, dementia severity, and daily function. Semantic memory task performance at 1 year had worsened one-third to one-half standard deviation. Factor analysis of baseline test scores distinguished processes in semantic and lexical retrieval (semantic recognition, semantic naming, confrontation naming) from processes in lexical search (semantic density, category fluency). The semantic-lexical retrieval factor predicted global cognition at 1 year. Considered separately, baseline confrontation naming and category fluency predicted dementia severity, while semantic recognition and a composite of semantic recognition and semantic naming predicted global cognition. No individual semantic memory test predicted daily function. Semantic-lexical retrieval and lexical search may represent distinct aspects of semantic memory. Semantic memory processes are sensitive to cognitive decline and dementia severity in Alzheimer disease.

  7. A Survey on the Semantic Field of ‘Vagabond’

    Directory of Open Access Journals (Sweden)

    Avishek Ray

    2017-10-01

    Full Text Available How we perceive a certain concept is grounded in the ‘language game’: the values, prejudices, dispositions, and cultural baggage among its interpretive communities. In other words, there is no ‘true meaning’ inherent in a word per se; rather the meaning is derived out of what Derrida (1993 calls the ‘chain’ of signification: the context, history, contingency, and often semantic contradictions that render a word polysemic. Taking off from here, this paper seeks to unpack the social ‘constructivism’ immanent in the a priori assumptions that cloak the idea of the ‘vagabond’. While invoking the contingency in the genesis and semantic history of ‘vagabond’ as a case study, this paper illustrates how meanings of certain heuristic concepts – in this case, ‘vagabond’, without a fixed referent – are often (reconfigured, not because of reasons entirely linguistic, but rather due to changes in the prevailing epistemic paradigms.

  8. Comparison of toxicological and radiological aspects of K basins sludge

    International Nuclear Information System (INIS)

    RITTMANN, P.D.

    1999-01-01

    The composition of various K Basins sludge is evaluated for its toxicological and radiological impacts downwind from accidents. It is shown that the radiological risk evaluation guidelines are always more limiting than the toxicological risk evaluation guidelines

  9. The Pivotal Role of Semantic Memory in Remembering the Past and Imagining the Future

    Science.gov (United States)

    Irish, Muireann; Piguet, Olivier

    2013-01-01

    Episodic memory refers to a complex and multifaceted process which enables the retrieval of richly detailed evocative memories from the past. In contrast, semantic memory is conceptualized as the retrieval of general conceptual knowledge divested of a specific spatiotemporal context. The neural substrates of the episodic and semantic memory systems have been dissociated in healthy individuals during functional imaging studies, and in clinical cohorts, leading to the prevailing view that episodic and semantic memory represent functionally distinct systems subtended by discrete neurobiological substrates. Importantly, however, converging evidence focusing on widespread neural networks now points to significant overlap between those regions essential for retrieval of autobiographical memories, episodic learning, and semantic processing. Here we review recent advances in episodic memory research focusing on neurodegenerative populations which has proved revelatory for our understanding of the complex interplay between episodic and semantic memory. Whereas episodic memory research has traditionally focused on retrieval of autobiographical events from the past, we also include evidence from the recent paradigm shift in which episodic memory is viewed as an adaptive and constructive process which facilitates the imagining of possible events in the future. We examine the available evidence which converges to highlight the pivotal role of semantic memory in providing schemas and meaning whether one is engaged in autobiographical retrieval for the past, or indeed, is endeavoring to construct a plausible scenario of an event in the future. It therefore seems plausible to contend that semantic processing may underlie most, if not all, forms of episodic memory, irrespective of temporal condition. PMID:23565081

  10. Beyond the VWFA: The orthography-semantics interface in spelling and reading

    Science.gov (United States)

    Purcell, Jeremy J.; Shea, Jennifer; Rapp, Brenda

    2014-01-01

    Lexical orthographic information provides the basis for recovering the meanings of words in reading and for generating correct word spellings in writing. Research has provided evidence that an area of the left ventral temporal cortex, a sub-region of what is often referred to as the Visual Word Form Area (VWFA), plays a significant role specifically in lexical orthographic processing. The current investigation goes beyond this previous work by examining the neurotopography of the interface of lexical orthography with semantics. We apply a novel lesion mapping approach with three individuals with acquired dysgraphia and dyslexia who suffered lesions to left ventral temporal cortex. To map cognitive processes to their neural substrates, this lesion mapping approach applies similar logical constraints as used in cognitive neuropsychological research. Using this approach, this investigation: (1) Identifies a region anterior to the VWFA that is important in the interface of orthographic information with semantics for reading and spelling; (2) Determines that, within this Orthography-Semantics Interface Region (OSIR), access to orthography from semantics (spelling) is topographically distinct from access to semantics from orthography (reading); (3) Provides evidence that, within this region, there is modality-specific access to and from lexical semantics for both spoken and written modalities, in both word production and comprehension. Overall, this study contributes to our understanding of the neural architecture at the lexical orthography-semantic-phonological interface within left ventral temporal cortex. PMID:24833190

  11. Differentiation of perceptual and semantic subsequent memory effects using an orthographic paradigm.

    Science.gov (United States)

    Kuo, Michael C C; Liu, Karen P Y; Ting, Kin Hung; Chan, Chetwyn C H

    2012-11-27

    This study aimed to differentiate perceptual and semantic encoding processes using subsequent memory effects (SMEs) elicited by the recognition of orthographs of single Chinese characters. Participants studied a series of Chinese characters perceptually (by inspecting orthographic components) or semantically (by determining the object making sounds), and then made studied or unstudied judgments during the recognition phase. Recognition performance in terms of d-prime measure in the semantic condition was higher, though not significant, than that of the perceptual condition. The between perceptual-semantic condition differences in SMEs at P550 and late positive component latencies (700-1000ms) were not significant in the frontal area. An additional analysis identified larger SME in the semantic condition during 600-1000ms in the frontal pole regions. These results indicate that coordination and incorporation of orthographic information into mental representation is essential to both task conditions. The differentiation was also revealed in earlier SMEs (perceptual>semantic) at N3 (240-360ms) latency, which is a novel finding. The left-distributed N3 was interpreted as more efficient processing of meaning with semantically learned characters. Frontal pole SMEs indicated strategic processing by executive functions, which would further enhance memory. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. Modulation of alpha oscillations is required for the suppression of semantic interference.

    Science.gov (United States)

    Melnik, Natalia; Mapelli, Igor; Özkurt, Tolga Esat

    2017-10-01

    Recent findings on alpha band oscillations suggest their important role in memory consolidation and suppression of external distractors such as environmental noise. However, less attention was given to the phenomenon of internal distracting information being solely inherent to the stimuli content. Human memory may be prone to internal distractions caused by semantic relatedness between the meaning of words (e.g., atom, neutron, nucleus, etc.) to be encoded, i.e., semantic interference. Our study investigates the brain oscillatory dynamics behind the semantic interference phenomenon, whose possible outcome is known as false memories. In this direction, Deese-Roediger-McDermott word lists were appropriated for a modified Sternberg paradigm in auditory modality. Participants received semantically related and unrelated word lists via headphones while EEG data were acquired. Semantic interference triggered the false memory rates to be higher than those of other types of memory errors. Analysis demonstrated that the upper part of alpha band (∼10-12Hz) power decreases on parieto-occipital channels in the retention interval, prior to the probe item for semantically related condition. Our study elucidates the oscillatory mechanisms behind semantic interference by relying on alpha functional inhibition theory. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Toxicological benchmarks for wildlife: 1996 Revision

    International Nuclear Information System (INIS)

    Sample, B.E.; Opresko, D.M.; Suter, G.W., II.

    1996-06-01

    The purpose of this report is to present toxicological benchmarks for assessment of effects of certain chemicals on mammalian and avian wildlife species. Publication of this document meets a milestone for the Environmental Restoration (ER) Risk Assessment Program. This document provides the ER Program with toxicological benchmarks that may be used as comparative tools in screening assessments as well as lines of evidence to support or refute the presence of ecological effects in ecological risk assessments. The chemicals considered in this report are some that occur at US DOE waste sites, and the wildlife species evaluated herein were chosen because they represent a range of body sizes and diets

  14. IRIS Toxicological Review of Trichloroethylene (TCE) ...

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroethylene (TCE) that when finalized will appear on the Integrated Risk Information System (IRIS) database. The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to trichloroethylene. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of trichloroethylene.

  15. [Forensic toxicology, a growing scientific discipline].

    Science.gov (United States)

    Augsburger, Marc; Staub, Christian

    2008-07-02

    Forensic toxicology has to bring evidence of substances that could have been involved directly or indirectly in the cause of death or that could influence the behaviour of somebody. The increase of the consumption of illegal and legal drugs in modern societies during last decades gave a boost to forensic toxicology. Moreover, improvement with analytical technology gave tools with high degrees of sensitivity and specificity for the screening and quantification of a large amount of substances in various biological specimens, even with very low concentration resulting of a single dose of medication.

  16. Toxicological benchmarks for wildlife: 1996 Revision

    Energy Technology Data Exchange (ETDEWEB)

    Sample, B.E.; Opresko, D.M.; Suter, G.W., II

    1996-06-01

    The purpose of this report is to present toxicological benchmarks for assessment of effects of certain chemicals on mammalian and avian wildlife species. Publication of this document meets a milestone for the Environmental Restoration (ER) Risk Assessment Program. This document provides the ER Program with toxicological benchmarks that may be used as comparative tools in screening assessments as well as lines of evidence to support or refute the presence of ecological effects in ecological risk assessments. The chemicals considered in this report are some that occur at US DOE waste sites, and the wildlife species evaluated herein were chosen because they represent a range of body sizes and diets.

  17. Discovery and Selection of Semantic Web Services

    CERN Document Server

    Wang, Xia

    2013-01-01

    For advanced web search engines to be able not only to search for semantically related information dispersed over different web pages, but also for semantic services providing certain functionalities, discovering semantic services is the key issue. Addressing four problems of current solution, this book presents the following contributions. A novel service model independent of semantic service description models is proposed, which clearly defines all elements necessary for service discovery and selection. It takes service selection as its gist and improves efficiency. Corresponding selection algorithms and their implementation as components of the extended Semantically Enabled Service-oriented Architecture in the Web Service Modeling Environment are detailed. Many applications of semantic web services, e.g. discovery, composition and mediation, can benefit from a general approach for building application ontologies. With application ontologies thus built, services are discovered in the same way as with single...

  18. IBRI-CASONTO: Ontology-based semantic search engine

    OpenAIRE

    Awny Sayed; Amal Al Muqrishi

    2017-01-01

    The vast availability of information, that added in a very fast pace, in the data repositories creates a challenge in extracting correct and accurate information. Which has increased the competition among developers in order to gain access to technology that seeks to understand the intent researcher and contextual meaning of terms. While the competition for developing an Arabic Semantic Search systems are still in their infancy, and the reason could be traced back to the complexity of Arabic ...

  19. SEMANTIC NETWORKS: THEORETICAL, TECHNICAL, METHODOLOGIC AND ANALYTICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    José Ángel Vera Noriega

    2005-09-01

    Full Text Available This work is a review of the methodological procedures and cares for the measurement of the connotative meanings which will be used in the elaboration of instruments with ethnic validity. Beginning from the techniques originally proposed by Figueroa et al. (1981 and later described by Lagunes (1993, the intention is to offer a didactic panorama to carry out the measurement by semantic networks introducing some recommendations derived from the studies performed with this method.

  20. An Algebraic Specification of the Semantic Web

    OpenAIRE

    Ksystra, Katerina; Triantafyllou, Nikolaos; Stefaneas, Petros; Frangos, Panayiotis

    2011-01-01

    We present a formal specification of the Semantic Web, as an extension of the World Wide Web using the well known algebraic specification language CafeOBJ. Our approach allows the description of the key elements of the Semantic Web technologies, in order to give a better understanding of the system, without getting involved with their implementation details that might not yet be standardized. This specification is part of our work in progress concerning the modeling the Social Semantic Web.

  1. Semantic Web Requirements through Web Mining Techniques

    OpenAIRE

    Hassanzadeh, Hamed; Keyvanpour, Mohammad Reza

    2012-01-01

    In recent years, Semantic web has become a topic of active research in several fields of computer science and has applied in a wide range of domains such as bioinformatics, life sciences, and knowledge management. The two fast-developing research areas semantic web and web mining can complement each other and their different techniques can be used jointly or separately to solve the issues in both areas. In addition, since shifting from current web to semantic web mainly depends on the enhance...

  2. 40 CFR 161.340 - Toxicology data requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Toxicology data requirements. 161.340... Toxicology data requirements. (a) Table. Sections 161.100 through 161.102 describe how to use this table to determine the toxicology data requirements and the substance to be tested. Kind of data required (b) Notes...

  3. Three lessons for genetic toxicology from baseball analytics.

    Science.gov (United States)

    Dertinger, Stephen D

    2017-07-01

    In many respects the evolution of baseball statistics mirrors advances made in the field of genetic toxicology. From its inception, baseball and statistics have been inextricably linked. Generations of players and fans have used a number of relatively simple measurements to describe team and individual player's current performance, as well as for historical record-keeping purposes. Over the years, baseball analytics has progressed in several important ways. Early advances were based on deriving more meaningful metrics from simpler forerunners. Now, technological innovations are delivering much deeper insights. Videography, radar, and other advances that include automatic player recognition capabilities provide the means to measure more complex and useful factors. Fielders' reaction times, efficiency of the route taken to reach a batted ball, and pitch-framing effectiveness come to mind. With the current availability of complex measurements from multiple data streams, multifactorial analyses occurring via machine learning algorithms have become necessary to make sense of the terabytes of data that are now being captured in every Major League Baseball game. Collectively, these advances have transformed baseball statistics from being largely descriptive in nature to serving data-driven, predictive roles. Whereas genetic toxicology has charted a somewhat parallel course, a case can be made that greater utilization of baseball's mindset and strategies would serve our scientific field well. This paper describes three useful lessons for genetic toxicology, courtesy of the field of baseball analytics: seek objective knowledge; incorporate multiple data streams; and embrace machine learning. Environ. Mol. Mutagen. 58:390-397, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  4. Risk assessment and toxicology databases for health effects assessment

    Energy Technology Data Exchange (ETDEWEB)

    Lu, P.Y.; Wassom, J.S. [Oak Ridge National Laboratory, TN (United States)

    1990-12-31

    Scientific and technological developments bring unprecedented stress to our environment. Society has to predict the results of potential health risks from technologically based actions that may have serious, far-reaching consequences. The potential for error in making such predictions or assessment is great and multiplies with the increasing size and complexity of the problem being studied. Because of this, the availability and use of reliable data is the key to any successful forecasting effort. Scientific research and development generate new data and information. Much of the scientific data being produced daily is stored in computers for subsequent analysis. This situation provides both an invaluable resource and an enormous challenge. With large amounts of government funds being devoted to health and environmental research programs and with maintenance of our living environment at stake, we must make maximum use of the resulting data to forecast and avert catastrophic effects. Along with the readily available. The most efficient means of obtaining the data necessary for assessing the health effects of chemicals is to utilize applications include the toxicology databases and information files developed at ORNL. To make most efficient use of the data/information that has already been prepared, attention and resources should be directed toward projects that meticulously evaluate the available data/information and create specialized peer-reviewed value-added databases. Such projects include the National Library of Medicine`s Hazardous Substances Data Bank, and the U.S. Air Force Installation Restoration Toxicology Guide. These and similar value-added toxicology databases were developed at ORNL and are being maintained and updated. These databases and supporting information files, as well as some data evaluation techniques are discussed in this paper with special focus on how they are used to assess potential health effects of environmental agents. 19 refs., 5 tabs.

  5. Some Novel Techniques in Operational Semantics

    DEFF Research Database (Denmark)

    Mosses, Peter David

    2003-01-01

    Several novel techniques for use in operational semantics are presented. They were developed in connection with a modular vatriant of the conventional Structural Operational Semantics framework, but can also be exploited when modularity is of no great concern. Gives a simple introduction to the m......Several novel techniques for use in operational semantics are presented. They were developed in connection with a modular vatriant of the conventional Structural Operational Semantics framework, but can also be exploited when modularity is of no great concern. Gives a simple introduction...

  6. Language networks associated with computerized semantic indices.

    Science.gov (United States)

    Pakhomov, Serguei V S; Jones, David T; Knopman, David S

    2015-01-01

    Tests of generative semantic verbal fluency are widely used to study organization and representation of concepts in the human brain. Previous studies demonstrated that clustering and switching behavior during verbal fluency tasks is supported by multiple brain mechanisms associated with semantic memory and executive control. Previous work relied on manual assessments of semantic relatedness between words and grouping of words into semantic clusters. We investigated a computational linguistic approach to measuring the strength of semantic relatedness between words based on latent semantic analysis of word co-occurrences in a subset of a large online encyclopedia. We computed semantic clustering indices and compared them to brain network connectivity measures obtained with task-free fMRI in a sample consisting of healthy participants and those differentially affected by cognitive impairment. We found that semantic clustering indices were associated with brain network connectivity in distinct areas including fronto-temporal, fronto-parietal and fusiform gyrus regions. This study shows that computerized semantic indices complement traditional assessments of verbal fluency to provide a more complete account of the relationship between brain and verbal behavior involved organization and retrieval of lexical information from memory. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Semantic models for adaptive interactive systems

    CERN Document Server

    Hussein, Tim; Lukosch, Stephan; Ziegler, Jürgen; Calvary, Gaëlle

    2013-01-01

    Providing insights into methodologies for designing adaptive systems based on semantic data, and introducing semantic models that can be used for building interactive systems, this book showcases many of the applications made possible by the use of semantic models.Ontologies may enhance the functional coverage of an interactive system as well as its visualization and interaction capabilities in various ways. Semantic models can also contribute to bridging gaps; for example, between user models, context-aware interfaces, and model-driven UI generation. There is considerable potential for using

  8. Neural correlates underlying musical semantic memory.

    Science.gov (United States)

    Groussard, M; Viader, F; Landeau, B; Desgranges, B; Eustache, F; Platel, H

    2009-07-01

    Numerous functional imaging studies have examined the neural basis of semantic memory mainly using verbal and visuospatial materials. Musical material also allows an original way to explore semantic memory processes. We used PET imaging to determine the neural substrates that underlie musical semantic memory using different tasks and stimuli. The results of three PET studies revealed a greater involvement of the anterior part of the temporal lobe. Concerning clinical observations and our neuroimaging data, the musical lexicon (and most widely musical semantic memory) appears to be sustained by a temporo-prefrontal cerebral network involving right and left cerebral regions.

  9. Towards a Reactive Semantic Execution Environment

    Science.gov (United States)

    Komazec, Srdjan; Facca, Federico Michele

    Managing complex and distributed software systems built on top of the service-oriented paradigm has never been more challenging. While Semantic Web Service technologies offer a promising set of languages and tools as a foundation to resolve the heterogeneity and scalability issues, they are still failing to provide an autonomic execution environment. In this paper we present an approach based on Semantic Web Services to enable the monitoring and self-management of a Semantic Execution Environment (SEE), a brokerage system for Semantic Web Services. Our approach is founded on the event-triggered reactivity paradigm in order to facilitate environment control, thus contributing to its autonomicity, robustness and flexibility.

  10. Semantics-based Automated Web Testing

    Directory of Open Access Journals (Sweden)

    Hai-Feng Guo

    2015-08-01

    Full Text Available We present TAO, a software testing tool performing automated test and oracle generation based on a semantic approach. TAO entangles grammar-based test generation with automated semantics evaluation using a denotational semantics framework. We show how TAO can be incorporated with the Selenium automation tool for automated web testing, and how TAO can be further extended to support automated delta debugging, where a failing web test script can be systematically reduced based on grammar-directed strategies. A real-life parking website is adopted throughout the paper to demonstrate the effectivity of our semantics-based web testing approach.

  11. Semantic, phonologic, and verb fluency in Huntington's disease

    Directory of Open Access Journals (Sweden)

    Mariana Jardim Azambuja

    Full Text Available Abstract Verbal fluency tasks have been identified as important indicators of executive functioning impairment in patients with frontal lobe dysfunction. Although the usual evaluation of this ability considers phonologic and semantic criteria, there is some evidence that fluency of verbs would be more sensitive in disclosing frontostriatal physiopathology since frontal regions primarily mediate retrieval of verbs. Huntington's disease usually affects these circuitries. Objective: To compare three types of verbal fluency task in the assessment of frontal-striatal dysfunction in HD subjects. Methods: We studied 26 Huntington's disease subjects, divided into two subgroups: mild (11 and moderate (15 along with 26 normal volunteers matched for age, gender and schooling, for three types of verbal fluency: phonologic fluency (F-A-S, semantic fluency and fluency of verbs. Results: Huntington's disease subjects showed a significant reduction in the number of words correctly generated in the three tasks when compared to the normal group. Both controls and Huntington's disease subjects showed a similar pattern of decreasing task performance with the greatest number of words being generated by semantic elicitation followed by verbs and lastly phonologic criteria. We did not find greater production of verbs compared with F-A-S and semantic conditions. Moreover, the fluency of verbs distinguished only the moderate group from controls. Conclusion: Our results indicated that phonologic and semantic fluency can be used to evaluate executive functioning, proving more sensitive than verb fluency. However, it is important to point out that the diverse presentations of Huntington's disease means that an extended sample is necessary for more consistent analysis of this issue.

  12. GRAPHIC REALIZATION FOUNDATIONS OF LOGIC-SEMANTIC MODELING IN DIDACTICS

    Directory of Open Access Journals (Sweden)

    V. E. Steinberg

    2017-01-01

    Full Text Available Introduction. Nowadays, there are not a lot of works devoted to a graphic method of logic-semantic modeling of knowledge. Meanwhile, an interest towards this method increases due to the fact of essential increase of the content of visual component in information and educational sources. The present publication is the authors’ contribution into the solution of the problem of search of new forms and means convenient for visual and logic perception of a training material, its assimilation, operating by elements of knowledge and their transformations.The aim of the research is to justify graphical implementation of the method of logic-semantic modeling of knowledge, presented by a natural language (training language and to show the possibilities of application of figurative and conceptual models in student teaching.Methodology and research methods. The research methodology is based on the specified activity-regulatory, system-multi-dimensional and structural-invariant approach and the principle of multidimensionality. The methodology the graphic realization of the logic-semantic models in learning technologies is based on didactic design using computer training programs.Results and scientific novelty. Social and anthropological-cultural adaptation bases of the method of logical-semantic knowledge modeling to the problems of didactics are established and reasoned: coordinate-invariant matrix structure is presented as the basis of logical-semantic models of figurative and conceptual nature; the possibilities of using such models as multifunctional didactic regulators – support schemes, navigation in the content of the educational material, educational activities carried out by navigators, etc., are shown. The characteristics of new teaching tools as objects of semiotics and didactic of regulators are considered; their place and role in the structure of the external and internal training curricula learning activities are pointed out

  13. Fine-coarse semantic processing in schizophrenia: a reversed pattern of hemispheric dominance.

    Science.gov (United States)

    Zeev-Wolf, Maor; Goldstein, Abraham; Levkovitz, Yechiel; Faust, Miriam

    2014-04-01

    Left lateralization for language processing is a feature of neurotypical brains. In individuals with schizophrenia, lack of left lateralization is associated with the language impairments manifested in this population. Beeman׳s fine-coarse semantic coding model asserts left hemisphere specialization in fine (i.e., conventionalized) semantic coding and right hemisphere specialization in coarse (i.e., non-conventionalized) semantic coding. Applying this model to schizophrenia would suggest that language impairments in this population are a result of greater reliance on coarse semantic coding. We investigated this hypothesis and examined whether a reversed pattern of hemispheric involvement in fine-coarse semantic coding along the time course of activation could be detected in individuals with schizophrenia. Seventeen individuals with schizophrenia and 30 neurotypical participants were presented with two word expressions of four types: literal, conventional metaphoric, unrelated (exemplars of fine semantic coding) and novel metaphoric (an exemplar of coarse semantic coding). Expressions were separated by either a short (250 ms) or long (750 ms) delay. Findings indicate that whereas during novel metaphor processing, controls displayed a left hemisphere advantage at 250 ms delay and right hemisphere advantage at 750 ms, individuals with schizophrenia displayed the opposite. For conventional metaphoric and unrelated expressions, controls showed left hemisphere advantage across times, while individuals with schizophrenia showed a right hemisphere advantage. Furthermore, whereas individuals with schizophrenia were less accurate than control at judging literal, conventional metaphoric and unrelated expressions they were more accurate when judging novel metaphors. Results suggest that individuals with schizophrenia display a reversed pattern of lateralization for semantic coding which causes them to rely more heavily on coarse semantic coding. Thus, for individuals with

  14. A Semantic Analysis of the Language of Advertising | Emodi | African ...

    African Journals Online (AJOL)

    A Semantic Analysis of the Language of Advertising. ... After a brief introduction to semantics and advertising language, the paper is focused on the linguistic realizations in English advertising from the semantic ... AJOL African Journals Online.

  15. Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

    NARCIS (Netherlands)

    Heijne, W.H.M.; Kienhuis, A.S.; Ommen, van B.; Stierum, R.; Groten, J.P.

    2005-01-01

    Toxicogenomics can facilitate the identification and characterization of toxicity, as illustrated in this review. Toxicogenomics, the application of the functional genomics technologies (transcriptomics, proteomics and metabolomics) in toxicology enables the study of adverse effects of xenobiotic

  16. Toxicological aspects of fuel and exhaust gas

    International Nuclear Information System (INIS)

    Avella, F.

    1993-01-01

    Some aspects concerning fuels (gasoline) and gas exhaust vehicle emissions toxicology are briefly examined in light of the results reported in recent literature on this argument. Many experimental studies carried out on animals and men turn out incomplete and do not allow thorough evaluations, for every aspect, of the risk to which men and the environment are subjected

  17. Evolution of Computational Toxicology-from Primitive ...

    Science.gov (United States)

    Presentation at the Health Canada seminar in Ottawa, ON, Canada on Nov. 15. 2016 Presentation at the Health Canada seminar in Ottawa, ON, Canada on Nov. 15. 2016 on the Evolution of Computational Toxicology-from Primitive Beginnings to Sophisticated Application

  18. Research Models in Developmental Behavioral Toxicology.

    Science.gov (United States)

    Dietrich, Kim N.; Pearson, Douglas T.

    Developmental models currently used by child behavioral toxicologists and teratologists are inadequate to address current issues in these fields. Both child behavioral teratology and toxicology scientifically study the impact of exposure to toxic agents on behavior development: teratology focuses on prenatal exposure and postnatal behavior…

  19. A medical-toxicological view of tattooing

    DEFF Research Database (Denmark)

    Laux, Peter; Tralau, Tewes; Tentschert, Jutta

    2016-01-01

    of infections. Meanwhile, the increasing popularity of tattooing has led to the development of many new colours, allowing tattoos to be more spectacular than ever before. However, little is known about the toxicological risks of the ingredients used. For risk assessment, safe intradermal application...

  20. Toxicodynetics: A new discipline in clinical toxicology.

    Science.gov (United States)

    Baud, F J; Houzé, P; Villa, A; Borron, S W; Carli, P

    2016-05-01

    Regarding the different disciplines that encompass the pharmacology and the toxicology, none is specifically dedicated to the description and analysis of the time-course of relevant toxic effects both in experimental and clinical studies. The lack of a discipline devoted to this major field in toxicology results in misconception and even in errors by clinicians. Review of the basic different disciplines that encompass pharmacology toxicology and comparing with the description of the time-course of effects in conditions in which toxicological analysis was not performed or with limited analytical evidence. Review of the literature clearly shows how misleading is the current extrapolation of toxicokinetic data to the description of the time-course of toxic effects. A new discipline entitled toxicodynetics should be developed aiming at a more systematic description of the time-course of effects in acute human and experimental poisonings. Toxicodynetics might help emergency physicians in risk assessment when facing a poisoning and contribute to a better assessment of quality control of data collected by poison control centres. Toxicodynetics would also allow a quantitative approach to the clinical effects resulting from drug-drug interaction. Copyright © 2016. Published by Elsevier Masson SAS.