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Sample records for mci correspondence training

  1. Cognitive Training Program to Improve Working Memory in Older Adults with MCI.

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    Hyer, Lee; Scott, Ciera; Atkinson, Mary Michael; Mullen, Christine M; Lee, Anna; Johnson, Aaron; Mckenzie, Laura C

    2016-01-01

    Deficits in working memory (WM) are associated with age-related decline. We report findings from a clinical trial that examined the effectiveness of Cogmed, a computerized program that trains WM. We compare this program to a Sham condition in older adults with Mild Cognitive Impairment (MCI). Older adults (N = 68) living in the community were assessed. Participants reported memory impairment and met criteria for MCI, either by poor delayed memory or poor performance in other cognitive areas. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS, Delayed Memory Index) and the Clinical Dementia Rating scale (CDR) were utilized. All presented with normal Mini Mental State Exams (MMSE) and activities of daily living (ADLs). Participants were randomized to Cogmed or a Sham computer program. Twenty-five sessions were completed over five to seven weeks. Pre, post, and follow-up measures included a battery of cognitive measures (three WM tests), a subjective memory scale, and a functional measure. Both intervention groups improved over time. Cogmed significantly outperformed Sham on Span Board and exceeded in subjective memory reports at follow-up as assessed by the Cognitive Failures Questionnaire (CFQ). The Cogmed group demonstrated better performance on the Functional Activities Questionnaire (FAQ), a measure of adjustment and far transfer, at follow-up. Both groups, especially Cogmed, enjoyed the intervention. Results suggest that WM was enhanced in both groups of older adults with MCI. Cogmed was better on one core WM measure and had higher ratings of satisfaction. The Sham condition declined on adjustment.

  2. Comparison of Resistance and Chair Yoga Training on Subjective Sleep Quality in MCI Women

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    Maria Karydaki

    2017-01-01

    Full Text Available Background: Self-rated sleep disorders are common in older adults, resulting in various health problems. Two types of exercise are suggested as an affordable and accessible non-pharmacological treatment and are being compared and discussed. Objectives: This randomized, controlled, 12-week trial investigates the effects of different types of exercise (resistance vs chair yoga training on subjective sleep quality, in women with Mild Cognitive Impairment (MCI. Methods: In order to measure cognitive function, the Mini-Mental State Examination (MMSE was used. Forty nine participants enrolled in the study were randomized to a resistance training program (n=16, or a chair yoga program (n=15, or a control group (n=18. All participants engaged in cognitive activities. Results: At baseline, PSQI scores for CYG, RTG and CG (8.2±5.1, 6.1±4.3, 7.4±4.1, respectively and MMSE (28.3±1.4, 27.8±1.2, 28.0±2.3, respectively did not differ statistically between the three groups (F2,46= 1.993, p= 0.143. After the intervention, a significant improvement in PSQI total score was noted in resistance training group (t=2.335, df15, p=0.03. Conclusions: There were no significant differences between groups before and after test for the PSQI subscale scores (sleep onset latency (h, time spent in bed before sleep (min, morning waking up (h and sleep duration (h. No significant difference was found in PSQI subscales scores within each group. This study proposes that resistance training is an effective treatment approach to improve sleep quality in women with mild cognitive impairment.

  3. Correspondence Training: An Example of Rule-Governed Behavior?

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    Deacon, Joseph R.; Konarski, Edward A., Jr.

    1987-01-01

    Results of a study comparing the outcome of a reinforcement (do only) procedure with correspondence (say/do) training indicated no apparent differences in generalization between two groups of mentally retarded adults (N=12). Rule-governed behavior, rather than verbal regulation of behavior, may best account for behavior changes seen in…

  4. Mild Cognitive Impairment (MCI)

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    Mild cognitive impairment (MCI) Overview Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and the more-serious decline of dementia. It ...

  5. The Memory Aid study: protocol for a randomized controlled clinical trial evaluating the effect of computer-based working memory training in elderly patients with mild cognitive impairment (MCI).

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    Flak, Marianne M; Hernes, Susanne S; Chang, Linda; Ernst, Thomas; Douet, Vanessa; Skranes, Jon; Løhaugen, Gro C C

    2014-05-03

    Mild cognitive impairment (MCI) is a condition characterized by memory problems that are more severe than the normal cognitive changes due to aging, but less severe than dementia. Reduced working memory (WM) is regarded as one of the core symptoms of an MCI condition. Recent studies have indicated that WM can be improved through computer-based training. The objective of this study is to evaluate if WM training is effective in improving cognitive function in elderly patients with MCI, and if cognitive training induces structural changes in the white and gray matter of the brain, as assessed by structural MRI. The proposed study is a blinded, randomized, controlled trail that will include 90 elderly patients diagnosed with MCI at a hospital-based memory clinic. The participants will be randomized to either a training program or a placebo version of the program. The intervention is computerized WM training performed for 45 minutes of 25 sessions over 5 weeks. The placebo version is identical in duration but is non-adaptive in the difficulty level of the tasks. Neuropsychological assessment and structural MRI will be performed before and 1 month after training, and at a 5-month folllow-up. If computer-based training results in positive changes to memory functions in patients with MCI this may represent a new, cost-effective treatment for MCI. Secondly, evaluation of any training-induced structural changes to gray or white matter will improve the current understanding of the mechanisms behind effective cognitive interventions in patients with MCI. ClinicalTrials.gov NCT01991405. November 18, 2013.

  6. Health effects from swimming training in chlorinated pools and the corresponding metabolic stress pathways.

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    Jiang-Hua Li

    Full Text Available Chlorination is the most popular method for disinfecting swimming pool water; however, although pathogens are being killed, many toxic compounds, called disinfection by-products (DBPs, are formed. Numerous epidemiological publications have associated the chlorination of pools with dysfunctions of the respiratory system and with some other diseases. However, the findings concerning these associations are not always consistent and have not been confirmed by toxicological studies. Therefore, the health effects from swimming in chlorinated pools and the corresponding stress reactions in organisms are unclear. In this study, we show that although the growth and behaviors of experimental rats were not affected, their health, training effects and metabolic profiles were significantly affected by a 12-week swimming training program in chlorinated water identical to that of public pools. Interestingly, the eyes and skin are the organs that are more directly affected than the lungs by the irritants in chlorinated water; instead of chlorination, training intensity, training frequency and choking on water may be the primary factors for lung damage induced by swimming. Among the five major organs (the heart, liver, spleen, lungs and kidneys, the liver is the most likely target of DBPs. Through metabolomics analysis, the corresponding metabolic stress pathways and a defensive system focusing on taurine were presented, based on which the corresponding countermeasures can be developed for swimming athletes and for others who spend a lot of time in chlorinated swimming pools.

  7. Multimodal manifold-regularized transfer learning for MCI conversion prediction.

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    Cheng, Bo; Liu, Mingxia; Suk, Heung-Il; Shen, Dinggang; Zhang, Daoqiang

    2015-12-01

    As the early stage of Alzheimer's disease (AD), mild cognitive impairment (MCI) has high chance to convert to AD. Effective prediction of such conversion from MCI to AD is of great importance for early diagnosis of AD and also for evaluating AD risk pre-symptomatically. Unlike most previous methods that used only the samples from a target domain to train a classifier, in this paper, we propose a novel multimodal manifold-regularized transfer learning (M2TL) method that jointly utilizes samples from another domain (e.g., AD vs. normal controls (NC)) as well as unlabeled samples to boost the performance of the MCI conversion prediction. Specifically, the proposed M2TL method includes two key components. The first one is a kernel-based maximum mean discrepancy criterion, which helps eliminate the potential negative effect induced by the distributional difference between the auxiliary domain (i.e., AD and NC) and the target domain (i.e., MCI converters (MCI-C) and MCI non-converters (MCI-NC)). The second one is a semi-supervised multimodal manifold-regularized least squares classification method, where the target-domain samples, the auxiliary-domain samples, and the unlabeled samples can be jointly used for training our classifier. Furthermore, with the integration of a group sparsity constraint into our objective function, the proposed M2TL has a capability of selecting the informative samples to build a robust classifier. Experimental results on the Alzheimer's Disease Neuroimaging Initiative (ADNI) database validate the effectiveness of the proposed method by significantly improving the classification accuracy of 80.1 % for MCI conversion prediction, and also outperforming the state-of-the-art methods.

  8. Cognitive Training Using a Novel Memory Game on an iPad in Patients with Amnestic Mild Cognitive Impairment (aMCI).

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    Savulich, George; Piercy, Thomas; Fox, Chris; Suckling, John; Rowe, James B; O'Brien, John T; Sahakian, Barbara J

    2017-08-01

    Cognitive training is effective in patients with mild cognitive impairment but does not typically address the motivational deficits associated with older populations with memory difficulties. We conducted a randomized controlled trial of cognitive training using a novel memory game on an iPad in 42 patients with a diagnosis of amnestic mild cognitive impairment assigned to either the cognitive training (n=21; 8 hours of gameplay over 4 weeks) or control (n=21; clinic visits as usual) groups. Significant time-by-pattern-by-group interactions were found for cognitive performance in terms of the number of errors made and trials needed on the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning task (P=.044; P=.027). Significant time-by-group interactions were also found for the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning first trial memory score (P=.002), Mini-Mental State Examination (P=.036), the Brief Visuospatial Memory Test (P=.032), and the Apathy Evaluation Scale (P=.026). Within-group comparisons revealed highly specific effects of cognitive training on episodic memory. The cognitive training group maintained high levels of enjoyment and motivation to continue after each hour of gameplay, with self-confidence and self-rated memory ability improving over time. Episodic memory robustly improved in the cognitive training group. "Gamified" cognitive training may also enhance visuospatial abilities in patients with amnestic mild cognitive impairment. Gamification maximizes engagement with cognitive training by increasing motivation and could complement pharmacological treatments for amnestic mild cognitive impairment and mild Alzheimer's disease. Larger, more controlled trials are needed to replicate and extend these findings. © The Author 2017. Published by Oxford University Press on behalf of CINP.

  9. Classifying MCI Subtypes in Community-Dwelling Elderly Using Cross-Sectional and Longitudinal MRI-Based Biomarkers

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    Hao Guan

    2017-09-01

    Full Text Available Amnestic MCI (aMCI and non-amnestic MCI (naMCI are considered to differ in etiology and outcome. Accurately classifying MCI into meaningful subtypes would enable early intervention with targeted treatment. In this study, we employed structural magnetic resonance imaging (MRI for MCI subtype classification. This was carried out in a sample of 184 community-dwelling individuals (aged 73–85 years. Cortical surface based measurements were computed from longitudinal and cross-sectional scans. By introducing a feature selection algorithm, we identified a set of discriminative features, and further investigated the temporal patterns of these features. A voting classifier was trained and evaluated via 10 iterations of cross-validation. The best classification accuracies achieved were: 77% (naMCI vs. aMCI, 81% (aMCI vs. cognitively normal (CN and 70% (naMCI vs. CN. The best results for differentiating aMCI from naMCI were achieved with baseline features. Hippocampus, amygdala and frontal pole were found to be most discriminative for classifying MCI subtypes. Additionally, we observed the dynamics of classification of several MRI biomarkers. Learning the dynamics of atrophy may aid in the development of better biomarkers, as it may track the progression of cognitive impairment.

  10. FEATURES OF THE INDEPENDENT WORK OF STUDENTS OF HIGHER EDUCATIONAL INSTITUTIONS IN THE CONDITIONS OF THE CORRESPONDENCE FORM OF TRAINING

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    Volodymyr V. Dyvak

    2013-03-01

    Full Text Available The article is devoted to the issues of introduction of information and communication technologies in educational process of higher educational institutions in the conditions of implementation of the correspondence form of training. Examples of the use of information and communication technologies in educational process of higher educational institutions, in particular in the preparation of specialists in pedagogics of higher school in the conditions of the correspondence form of training are presented. Discussed the basic didactic principles of distance and traditional forms of education. The theoretical substantiation of a choice of a virtual learning environment compass for the needs of training of specialists in pedagogics of higher school is presented. Determined the location of independent work of students in the educational process of higher education. Outputed the main functional modules of modern management systems of distance learning.

  11. Predicting conversion from MCI to AD using resting-state fMRI, graph theoretical approach and SVM.

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    Hojjati, Seyed Hani; Ebrahimzadeh, Ata; Khazaee, Ali; Babajani-Feremi, Abbas

    2017-04-15

    We investigated identifying patients with mild cognitive impairment (MCI) who progress to Alzheimer's disease (AD), MCI converter (MCI-C), from those with MCI who do not progress to AD, MCI non-converter (MCI-NC), based on resting-state fMRI (rs-fMRI). Graph theory and machine learning approach were utilized to predict progress of patients with MCI to AD using rs-fMRI. Eighteen MCI converts (average age 73.6 years; 11 male) and 62 age-matched MCI non-converters (average age 73.0 years, 28 male) were included in this study. We trained and tested a support vector machine (SVM) to classify MCI-C from MCI-NC using features constructed based on the local and global graph measures. A novel feature selection algorithm was developed and utilized to select an optimal subset of features. Using subset of optimal features in SVM, we classified MCI-C from MCI-NC with an accuracy, sensitivity, specificity, and the area under the receiver operating characteristic (ROC) curve of 91.4%, 83.24%, 90.1%, and 0.95, respectively. Furthermore, results of our statistical analyses were used to identify the affected brain regions in AD. To the best of our knowledge, this is the first study that combines the graph measures (constructed based on rs-fMRI) with machine learning approach and accurately classify MCI-C from MCI-NC. Results of this study demonstrate potential of the proposed approach for early AD diagnosis and demonstrate capability of rs-fMRI to predict conversion from MCI to AD by identifying affected brain regions underlying this conversion. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. The Test Your Memory for Mild Cognitive Impairment (TYM-MCI).

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    Brown, Jeremy M; Lansdall, Claire J; Wiggins, Julie; Dawson, Kate E; Hunter, Kristina; Rowe, James B; Parker, Richard A

    2017-12-01

    To validate a short cognitive test: the Test Your Memory for Mild Cognitive Impairment (TYM-MCI) in the diagnosis of patients with amnestic mild cognitive impairment or mild Alzheimer's disease (aMCI/AD). Two hundred and two patients with mild memory problems were recruited. All had 'passed' the Mini-Mental State Examination (MMSE). Patients completed the TYM-MCI, the Test Your Memory test (TYM), MMSE and revised Addenbrooke's Cognitive Examination (ACE-R), had a neurological examination, clinical diagnostics and multidisciplinary team review. As a single test, the TYM-MCI performed as well as the ACE-R in the distinction of patients with aMCI/AD from patients with subjective memory impairment with a sensitivity of 0.79 and specificity of 0.91. Used in combination with the ACE-R, it provided additional value and identified almost all cases of aMCI/AD. The TYM-MCI correctly classified most patients who had equivocal ACE-R scores. Integrated discriminant improvement analysis showed that the TYM-MCI added value to the conventional memory assessment. Patients initially diagnosed as unknown or with subjective memory impairment who were later rediagnosed with aMCI/AD scored poorly on their original TYM-MCI. The TYM-MCI is a powerful short cognitive test that examines verbal and visual recall and is a valuable addition to the assessment of patients with aMCI/AD. It is simple and cheap to administer and requires minimal staff time and training. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  13. Correspondence between training load executed by volleyball players and the one observed by coaches.

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    Rodríguez-Marroyo, Jose A; Medina, Javier; García-López, Juan; García-Tormo, José V; Foster, Carl

    2014-06-01

    The main aim of this study was to compare the training load (TL) executed by volleyball players with that observed by coaches. Second, we analyzed the influence of the coaches' experience in the estimated TL. Twelve female volleyball players and 4 male coaches participated in this study. During a period of 15 weeks, physical (PT) and technical-tactical training sessions and matches were monitored. In each session, the session rating of perceived exertion (sRPE) was recorded to analyze the players' exercise intensity and TL(RP)E. Coaches were present in all sessions and rated their estimate of sRPE at the same time as the players to calculate the coaches' TL(RPE). Both players' and coaches' mean sRPE (4.0 ± 1.1, 3.7 ± 1.1, and 3.8 ± 1.0 in players and expert and beginning coaches, respectively) and TLRPE (380.1 ± 106.8, 358.3 ± 110.5, and 359.7 ± 108.0 in players and expert and beginning coaches, respectively) were similar. However, a higher (p volleyball.

  14. Organizational methods conditions of formation of motivation at corresponding pedagogical skills to professional-applied physical training

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    Victorya Tsybul’ska

    2014-12-01

    Full Text Available Purpose: to develop organizational and methodological conditions of formation and motivation of students to determine their effectiveness. Materials and Methods: the study was conducted by third year student of the correspondence department of the Faculty of Primary Education (53 people. We used the following methods: survey of theoretical knowledge, motor tests, evaluation methods of physical health (G. Apanasenko, psychological methods of training motivation (T. Ilyina, motivation to succeed (T. Elers, rapid diagnosis empathy (I. Yusupova, methods of mathematical statistics. Results: the factors that affect the state of professionally-applied physical fitness of students of the correspondence department of the Faculty of Primary Education. Conclusions: the proposed organizational and methodological conditions activation independent of external students is the basis for providing in centives for self-study educational materials, improving theoretical knowledge in the field of physical education, increased motor activity through various forms of regular exercise.

  15. Clinical utility of FDG-PET for the clinical diagnosis in MCI.

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    Arbizu, Javier; Festari, Cristina; Altomare, Daniele; Walker, Zuzana; Bouwman, Femke; Rivolta, Jasmine; Orini, Stefania; Barthel, Henryk; Agosta, Federica; Drzezga, Alexander; Nestor, Peter; Boccardi, Marina; Frisoni, Giovanni Battista; Nobili, Flavio

    2018-04-27

    We aim to report the quality of accuracy studies investigating the utility of [ 18 F]fluorodeoxyglucose (FDG)-PET in supporting the diagnosis of prodromal Alzheimer's Disease (AD), frontotemporal lobar degeneration (FTLD) and prodromal dementia with Lewy bodies (DLB) in mild cognitive impairment (MCI) subjects, and the corresponding recommendations made by a panel of experts. Seven panellist, four from the European Association of Nuclear Medicine, and three from the European Academy of Neurology, produced recommendations taking into consideration the incremental value of FDG-PET, as added on clinical-neuropsychological examination, to ascertain the aetiology of MCI (AD, FTLD or DLB). A literature search using harmonized population, intervention, comparison, and outcome (PICO) strings was performed, and an evidence assessment consistent with the European Federation of Neurological Societies guidance was provided. The consensual recommendation was achieved based on Delphi rounds. Fifty-four papers reported the comparison of interest. The selected papers allowed the identification of FDG patterns that characterized MCI due to AD, FTLD and DLB. While clinical outcome studies supporting the diagnosis of MCI due to AD showed varying accuracies (ranging from 58 to 100%) and varying areas under the receiver-operator characteristic curves (0.66 to 0.97), no respective data were identified for MCI due to FTLD or for MCI due to DLB. However, the high negative predictive value of FDG-PET and the existence of different disease-specific patterns of hypometabolism support the consensus recommendations for the clinical use of this imaging technique in MCI subjects. FDG-PET has clinical utility on a fair level of evidence in detecting MCI due to AD. Although promising also in detecting MCI due to FTLD and MCI due to DLB, more research is needed to ultimately judge the clinical utility of FDG-PET in these entities.

  16. A Rehabilitation Protocol for Empowering Spatial Orientation in MCI. A Pilot Study.

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    Gadler, Erminia; Grassi, Alessandra; Riva, Giuseppe

    2009-01-01

    Spatial navigation is among the first cognitive functions to be impaired in Alzheimer's disease [1] and deficit in this domain is detectable earlier in patients with Mild Cognitive Impairment [2]. Since efficacy of cognitive training in persons with MCI was successfully assessed [3], we developed a multitasking training protocol using virtual environments for stimulating attention, perception and visuo-spatial cognition in order to empower spatial orientation in MCI. Two healthy elders were exposed to the training over a period of four weeks and both showed improved performances in attention and orientation after the end of the intervention.

  17. Principal component analysis of FDG PET in amnestic MCI

    International Nuclear Information System (INIS)

    Nobili, Flavio; Girtler, Nicola; Brugnolo, Andrea; Dessi, Barbara; Rodriguez, Guido; Salmaso, Dario; Morbelli, Silvia; Piccardo, Arnoldo; Larsson, Stig A.; Pagani, Marco

    2008-01-01

    The purpose of the study is to evaluate the combined accuracy of episodic memory performance and 18 F-FDG PET in identifying patients with amnestic mild cognitive impairment (aMCI) converting to Alzheimer's disease (AD), aMCI non-converters, and controls. Thirty-three patients with aMCI and 15 controls (CTR) were followed up for a mean of 21 months. Eleven patients developed AD (MCI/AD) and 22 remained with aMCI (MCI/MCI). 18 F-FDG PET volumetric regions of interest underwent principal component analysis (PCA) that identified 12 principal components (PC), expressed by coarse component scores (CCS). Discriminant analysis was performed using the significant PCs and episodic memory scores. PCA highlighted relative hypometabolism in PC5, including bilateral posterior cingulate and left temporal pole, and in PC7, including the bilateral orbitofrontal cortex, both in MCI/MCI and MCI/AD vs CTR. PC5 itself plus PC12, including the left lateral frontal cortex (LFC: BAs 44, 45, 46, 47), were significantly different between MCI/AD and MCI/MCI. By a three-group discriminant analysis, CTR were more accurately identified by PET-CCS + delayed recall score (100%), MCI/MCI by PET-CCS + either immediate or delayed recall scores (91%), while MCI/AD was identified by PET-CCS alone (82%). PET increased by 25% the correct allocations achieved by memory scores, while memory scores increased by 15% the correct allocations achieved by PET. Combining memory performance and 18 F-FDG PET yielded a higher accuracy than each single tool in identifying CTR and MCI/MCI. The PC containing bilateral posterior cingulate and left temporal pole was the hallmark of MCI/MCI patients, while the PC including the left LFC was the hallmark of conversion to AD. (orig.)

  18. Principal component analysis of FDG PET in amnestic MCI

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    Nobili, Flavio; Girtler, Nicola; Brugnolo, Andrea; Dessi, Barbara; Rodriguez, Guido [University of Genoa, Clinical Neurophysiology, Department of Endocrinological and Medical Sciences, Genoa (Italy); S. Martino Hospital, Alzheimer Evaluation Unit, Genoa (Italy); S. Martino Hospital, Head-Neck Department, Genoa (Italy); Salmaso, Dario [CNR, Institute of Cognitive Sciences and Technologies, Rome (Italy); CNR, Institute of Cognitive Sciences and Technologies, Padua (Italy); Morbelli, Silvia [University of Genoa, Nuclear Medicine Unit, Department of Internal Medicine, Genoa (Italy); Piccardo, Arnoldo [Galliera Hospital, Nuclear Medicine Unit, Department of Imaging Diagnostics, Genoa (Italy); Larsson, Stig A. [Karolinska Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Pagani, Marco [CNR, Institute of Cognitive Sciences and Technologies, Rome (Italy); CNR, Institute of Cognitive Sciences and Technologies, Padua (Italy); Karolinska Hospital, Department of Nuclear Medicine, Stockholm (Sweden)

    2008-12-15

    The purpose of the study is to evaluate the combined accuracy of episodic memory performance and {sup 18}F-FDG PET in identifying patients with amnestic mild cognitive impairment (aMCI) converting to Alzheimer's disease (AD), aMCI non-converters, and controls. Thirty-three patients with aMCI and 15 controls (CTR) were followed up for a mean of 21 months. Eleven patients developed AD (MCI/AD) and 22 remained with aMCI (MCI/MCI). {sup 18}F-FDG PET volumetric regions of interest underwent principal component analysis (PCA) that identified 12 principal components (PC), expressed by coarse component scores (CCS). Discriminant analysis was performed using the significant PCs and episodic memory scores. PCA highlighted relative hypometabolism in PC5, including bilateral posterior cingulate and left temporal pole, and in PC7, including the bilateral orbitofrontal cortex, both in MCI/MCI and MCI/AD vs CTR. PC5 itself plus PC12, including the left lateral frontal cortex (LFC: BAs 44, 45, 46, 47), were significantly different between MCI/AD and MCI/MCI. By a three-group discriminant analysis, CTR were more accurately identified by PET-CCS + delayed recall score (100%), MCI/MCI by PET-CCS + either immediate or delayed recall scores (91%), while MCI/AD was identified by PET-CCS alone (82%). PET increased by 25% the correct allocations achieved by memory scores, while memory scores increased by 15% the correct allocations achieved by PET. Combining memory performance and {sup 18}F-FDG PET yielded a higher accuracy than each single tool in identifying CTR and MCI/MCI. The PC containing bilateral posterior cingulate and left temporal pole was the hallmark of MCI/MCI patients, while the PC including the left LFC was the hallmark of conversion to AD. (orig.)

  19. Neuropathology of mild cognitive impairment (MCI)

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    Murayama, Shigeo; Saito, Yuko

    2007-01-01

    Described are retrospective pathological studies on mild cognitive impairment (MCI) of brain specimens in the brain bank of authors' institute and current clinical studies of outpatients for screening of MCI based on those pathological findings. The study projects, aided by Ministry of Health, Labour and Welfare (MHLW) from 2003 and from 2007, have aimed to develop the optimal way for prophylaxis of dementia. In the former autopsy, about 10% of the elderly dead registered in the institute are found to have pathological changes of the clinical dementia rating 0.5, in whom the early Alzheimer disease (AD), Lewy body dementia, argentaffin granular disease and neurofibrillary tangle dominant disease are involved in a similar ratio to each other. Clinically, new patients with memory complaint are first screened by neurological tests involving CT, and then those with suspicious dementia undergo the second screening (2-day hospitalization) involving MRI with VSRAD (Voxel-based Specific Regional Analysis System for AD), ECD single photon emission computed tomography (SPECT) with eZis (easy Z-score imaging system), myocardial scintigraphy with homovanillic acid (HVA)/m-iodobenzylguanidine (MIBG), and if necessary, PET with fluorodeoxyglucose (FDG), PIB (Pittsburgh Compound B, an amyloid prove) and/or 11 C-CFT and 11 C-raclopride. Further, new patients with suspicious Parkinson disease undergo the screening (3-day) of various tests involving MRI with voxel-based morphometry and VSRAD, cerebral blood flow ECD SPECT with eZis and MIBG myocardial scintigraphy. It is concluded that AD is the most important subject in MCI and systemic diseases can also affect the cognitive ability as well. (R.T.)

  20. Two Minute Training in Class Significantly Increases the Use of Professional Formatting in Student to Faculty Email Correspondence

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    Aguilar-Roca, Nancy; Williams, Adrienne; Warrior, Rahul; O'Dowd, Diane K.

    2009-01-01

    Many university faculty value email as an important tool for communicating with colleagues, but express frustration with a high incidence of unprofessional email correspondence from students. The goals of this study were to document the frequency of specific formatting mistakes that contribute to faculty's unfavorable perception of student emails…

  1. Treinamento de habilidades fonológicas e correspondência grafema-fonema em crianças de risco para dislexia Phonological skills and grapheme-phoneme training correspondence in children under dyslexia risk

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    Maryse Tomoko Matsuzawa Fukuda

    2011-04-01

    Full Text Available OBJETIVO: verificar a eficácia do programa de treinamento fonológico e correspondência grafema-fonema em crianças de risco para dislexia da 1ª série. MÉTODOS: participaram deste estudo 30 crianças de 1ª série de ensino público, de ambos os gêneros, na faixa etária de 6 a 7 anos de idade. Neste estudo foi realizada a adaptação brasileira da pesquisa sobre treinamento de habilidades fonológicas e correspondência grafema-fonema composta de pré-testagem, intervenção e pós-testagem. Em situação de pré e pós-testagem, todas as crianças foram submetidas à aplicação do teste para identificação precoce dos problemas de leitura e aquelas que apresentaram desempenho inferior a 51% das provas do teste foram divididas em Grupo I (GI: composto por 15 crianças submetidas ao programa de treinamento; e em Grupo II (GII: composto por 15 crianças não submetidas ao programa de treinamento. RESULTADOS: os resultados desse estudo revelaram diferenças estatisticamente significantes, evidenciando que das 15 crianças submetidas ao programa, apenas uma não respondeu à intervenção proposta, sendo submetida, portanto, à avaliação interdisciplinar e confirmado o diagnóstico de dislexia. CONCLUSÃO: a realização do programa de treinamento das habilidades fonológicas e correspondência grafema-fonema foi eficaz para a identificação das crianças com sinais de dislexia, comprovado pela melhora das habilidades fonológicas e leitura em situação de pós-testagem em relação à pré-testagem, evidenciando que quando é fornecida a instrução formal do princípio alfabético associado ao principio de conversão letra-som da Língua Portuguesa, as crianças que não apresentam dislexia deixam de apresentar suas manifestações com resposta à instrução formal do princípio alfabético.PURPOSE: to check the efficacy of the phonological training and grapheme-phoneme correspondence program in first-grade children under dyslexia

  2. Foreign correspondence

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    Hamilton, John Maxwell

    2013-01-01

    Despite the importance of foreign news, its history, transformation and indeed its future have not been much studied. The scholarly community often calls attention to journalism's shortcomings covering the world, yet the topic has not been systematically examined across countries or over time. The need to redress this neglect and the desire to assess the impact of new media technologies on the future of journalism - including foreign correspondence - provide the motivation for this stimulating, exciting and thought-provoking book. While the old economic models supporting news have crumbled in

  3. Computer-assisted training of phoneme-grapheme correspondence for children who are deaf and hard of hearing: effects on phonological processing skills.

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    Nakeva von Mentzer, Cecilia; Lyxell, Björn; Sahlén, Birgitta; Wass, Malin; Lindgren, Magnus; Ors, Marianne; Kallioinen, Petter; Uhlén, Inger

    2013-12-01

    Examine deaf and hard of hearing (DHH) children's phonological processing skills in relation to a reference group of children with normal hearing (NH) at two baselines pre intervention. Study the effects of computer-assisted phoneme-grapheme correspondence training in the children. Specifically analyze possible effects on DHH children's phonological processing skills. The study included 48 children who participated in a computer-assisted intervention study, which focuses on phoneme-grapheme correspondence. Children were 5, 6, and 7 years of age. There were 32 DHH children using cochlear implants (CI) or hearing aids (HA), or both in combination, and 16 children with NH. The study had a quasi-experimental design with three test occasions separated in time by four weeks; baseline 1 and 2 pre intervention, and 3 post intervention. Children performed tasks measuring lexical access, phonological processing, and letter knowledge. All children were asked to practice ten minutes per day at home supported by their parents. NH children outperformed DHH children on the majority of tasks. All children improved their accuracy in phoneme-grapheme correspondence and output phonology as a function of the computer-assisted intervention. For the whole group of children, and specifically for children with CI, a lower initial phonological composite score was associated with a larger phonological change between baseline 2 and post intervention. Finally, 18 DHH children, whereof 11 children with CI, showed specific intervention effects on their phonological processing skills, and strong effect sizes for their improved accuracy of phoneme-grapheme correspondence. For some DHH children phonological processing skills are boosted relatively more by phoneme-grapheme correspondence training. This reflects the reciprocal relationship between phonological change and exposure to and manipulations of letters. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  4. Designing for Mild Cognitive Impairment (MCI): A Design Anthropological Perspective.

    Science.gov (United States)

    Collier, Guy; Kayes, Nicola; Reay, Stephen; Bill, Amanda

    2017-01-01

    This paper will present a design anthropological perspective on an ongoing project called 'Living Well with Mild Cognitive Impairment (MCI)'. The project explores how people with MCI (and their families) manage and respond to changes in their memory and thinking. One of the primary aims of this project is to design an online resource that will support people to 'Live Well' within the context of possible cognitive decline. The resource was originally proposed to function as a kind of online community, where users could both share and learn about home-grown strategies for managing the cognitive changes associated with MCI in everyday life. Much of this project has been guided by the methodological approach of design anthropology, which encourages project researchers and stakeholders to critically examine underlying assumptions and conceptual frameworks, which in this case revolve around the disputed MCI category. In this paper we will provide some background to the Living Well project before highlighting a number of key insights attained from design anthropology.

  5. Cortical hypermetabolism in MCI subjects: a compensatory mechanism?

    International Nuclear Information System (INIS)

    Ashraf, A.; Fan, Z.; Brooks, D.J.; Edison, P.

    2015-01-01

    Alzheimer's disease (AD) is associated with amyloid accumulation that takes place decades before symptoms appear. Cognitive impairment in AD is associated with reduced glucose metabolism. However, neuronal plasticity/compensatory mechanisms might come into play before the onset of dementia. The aim of this study was to determine whether there is evidence of cortical hypermetabolism as a compensatory mechanism before amyloid deposition takes place in subjects with amnestic mild cognitive impairment (aMCI). Nine AD subjects and ten aMCI subjects had both [ 11 C]PIB and [ 18 F]FDG PET scans with arterial input in order to quantify the amyloid deposition and glucose metabolism in vivo in comparison with healthy control subjects who underwent either [ 11 C]PIB or [ 18 F]FDG PET scans. The [ 11 C]PIB PET scans were quantified using [ 11 C]PIB target region to cerebellum uptake ratio images created by integrating the activity collected from 60 to 90 min, and regional cerebral glucose metabolism was quantified using spectral analysis. In MCI subjects, cortical hypermetabolism was observed in four amyloid-negative subjects and one amyloid-positive subject, while hypometabolism was seen in five other MCI subjects with high amyloid load. Subjects with hypermetabolism and low amyloid did not convert to AD during clinical follow-up for 18 months in contrast to four amyloid-positive hypometabolic subjects who did convert to AD. This preliminary study suggests that compensatory hypermetabolism can occur in aMCI subjects, particularly in those who are amyloid-negative. The increase in metabolic rate in different cortical regions with predominance in the occipital cortex may be a compensatory response to the neuronal damage occurring early in the disease process. It may also reflect recruitment of relatively minimally affected cortical regions to compensate for reduced function in the temporoparietal cortical association areas. (orig.)

  6. Cortical hypermetabolism in MCI subjects: a compensatory mechanism?

    Energy Technology Data Exchange (ETDEWEB)

    Ashraf, A.; Fan, Z.; Brooks, D.J.; Edison, P. [Imperial College London, Neurology Imaging Unit, Division of Brain Sciences, London (United Kingdom)

    2014-09-30

    Alzheimer's disease (AD) is associated with amyloid accumulation that takes place decades before symptoms appear. Cognitive impairment in AD is associated with reduced glucose metabolism. However, neuronal plasticity/compensatory mechanisms might come into play before the onset of dementia. The aim of this study was to determine whether there is evidence of cortical hypermetabolism as a compensatory mechanism before amyloid deposition takes place in subjects with amnestic mild cognitive impairment (aMCI). Nine AD subjects and ten aMCI subjects had both [{sup 11}C]PIB and [{sup 18}F]FDG PET scans with arterial input in order to quantify the amyloid deposition and glucose metabolism in vivo in comparison with healthy control subjects who underwent either [{sup 11}C]PIB or [{sup 18}F]FDG PET scans. The [{sup 11}C]PIB PET scans were quantified using [{sup 11}C]PIB target region to cerebellum uptake ratio images created by integrating the activity collected from 60 to 90 min, and regional cerebral glucose metabolism was quantified using spectral analysis. In MCI subjects, cortical hypermetabolism was observed in four amyloid-negative subjects and one amyloid-positive subject, while hypometabolism was seen in five other MCI subjects with high amyloid load. Subjects with hypermetabolism and low amyloid did not convert to AD during clinical follow-up for 18 months in contrast to four amyloid-positive hypometabolic subjects who did convert to AD. This preliminary study suggests that compensatory hypermetabolism can occur in aMCI subjects, particularly in those who are amyloid-negative. The increase in metabolic rate in different cortical regions with predominance in the occipital cortex may be a compensatory response to the neuronal damage occurring early in the disease process. It may also reflect recruitment of relatively minimally affected cortical regions to compensate for reduced function in the temporoparietal cortical association areas. (orig.)

  7. Microcystin mcyA and mcyE Gene Abundances Are Not Appropriate Indicators of Microcystin Concentrations in Lakes.

    Science.gov (United States)

    Beversdorf, Lucas J; Chaston, Sheena D; Miller, Todd R; McMahon, Katherine D

    2015-01-01

    Cyanobacterial harmful algal blooms (cyanoHABs) are a primary source of water quality degradation in eutrophic lakes. The occurrence of cyanoHABs is ubiquitous and expected to increase with current climate and land use change scenarios. However, it is currently unknown what environmental parameters are important for indicating the presence of cyanoHAB toxins making them difficult to predict or even monitor on time-scales relevant to protecting public health. Using qPCR, we aimed to quantify genes within the microcystin operon (mcy) to determine which cyanobacterial taxa, and what percentage of the total cyanobacterial community, were responsible for microcystin production in four eutrophic lakes. We targeted Microcystis-16S, mcyA, and Microcystis, Planktothrix, and Anabaena-specific mcyE genes. We also measured microcystins and several biological, chemical, and physical parameters--such as temperature, lake stability, nutrients, pigments and cyanobacterial community composition (CCC)--to search for possible correlations to gene copy abundance and MC production. All four lakes contained Microcystis-mcyE genes and high percentages of toxic Microcystis, suggesting Microcystis was the dominant microcystin producer. However, all genes were highly variable temporally, and in few cases, correlated with increased temperature and nutrients as the summer progressed. Interestingly, toxin gene abundances (and biomass indicators) were anti-correlated with microcystin in all lakes except the largest lake, Lake Mendota. Similarly, gene abundance and microcystins differentially correlated to CCC in all lakes. Thus, we conclude that the presence of microcystin genes are not a useful tool for eliciting an ecological role for toxins in the environment, nor are microcystin genes (e.g. DNA) a good indicator of toxins in the environment.

  8. Early identification of MCI converting to AD: a FDG PET study

    International Nuclear Information System (INIS)

    Pagani, Marco; Nobili, Flavio; Arnaldi, Dario; Brugnolo, Andrea; Picco, Agnese; Morbelli, Silvia; Bauckneht, Matteo; Piva, Roberta; Sambuceti, Gianmario; Giuliani, Alessandro; Oeberg, Johanna; Girtler, Nicola; Chincarini, Andrea; Jonsson, Cathrine; De Carli, Fabrizio

    2017-01-01

    Mild cognitive impairment (MCI) is a transitional pathological stage between normal ageing (NA) and Alzheimer's disease (AD). Although subjects with MCI show a decline at different rates, some individuals remain stable or even show an improvement in their cognitive level after some years. We assessed the accuracy of FDG PET in discriminating MCI patients who converted to AD from those who did not. FDG PET was performed in 42 NA subjects, 27 MCI patients who had not converted to AD at 5 years (nc-MCI; mean follow-up time 7.5 ± 1.5 years), and 95 MCI patients who converted to AD within 5 years (MCI-AD; mean conversion time 1.8 ± 1.1 years). Relative FDG uptake values in 26 meta-volumes of interest were submitted to ANCOVA and support vector machine analyses to evaluate regional differences and discrimination accuracy. The MCI-AD group showed significantly lower FDG uptake values in the temporoparietal cortex than the other two groups. FDG uptake values in the nc-MCI group were similar to those in the NA group. Support vector machine analysis discriminated nc-MCI from MCI-AD patients with an accuracy of 89% (AUC 0.91), correctly detecting 93% of the nc-MCI patients. In MCI patients not converting to AD within a minimum follow-up time of 5 years and MCI patients converting within 5 years, baseline FDG PET and volume-based analysis identified those who converted with an accuracy of 89%. However, further analysis is needed in patients with amnestic MCI who convert to a dementia other than AD. (orig.)

  9. Early identification of MCI converting to AD: a FDG PET study

    Energy Technology Data Exchange (ETDEWEB)

    Pagani, Marco [Institute of Cognitive Sciences and Technologies, CNR, Rome (Italy); Karolinska Hospital Stockholm, Department of Nuclear Medicine, Stockholm (Sweden); Nobili, Flavio; Arnaldi, Dario; Brugnolo, Andrea; Picco, Agnese [University of Genoa and IRCCS AOU San Martino-IST, Clinical Neurology, Department of Neuroscience (DINOGMI), Genoa (Italy); Morbelli, Silvia; Bauckneht, Matteo; Piva, Roberta; Sambuceti, Gianmario [University of Genoa and IRCCS AOU San Martino-IST, Department of Nuclear Medicine, Department of Health Science (DISSAL), Genoa (Italy); Giuliani, Alessandro [Istituto Superiore di Sanita, Environment and Health Department, Rome (Italy); Oeberg, Johanna [Karolinska Hospital, Department of Hospital Physics, Stockholm (Sweden); Girtler, Nicola [University of Genoa and IRCCS AOU San Martino-IST, Clinical Neurology, Department of Neuroscience (DINOGMI), Genoa (Italy); IRCCS AOU San Martino-IST, Clinical Psychology, Genoa (Italy); Chincarini, Andrea [National Institute of Nuclear Physics (INFN), Genoa section, Genoa (Italy); Jonsson, Cathrine [Karolinska University Hospital, Medical Radiation Physics and Nuclear Medicine, Imaging and Physiology, Stockholm (Sweden); De Carli, Fabrizio [AOU San Martino-IST, Institute of Molecular Bioimaging and Physiology, CNR - Genoa Unit, Genoa (Italy)

    2017-11-15

    Mild cognitive impairment (MCI) is a transitional pathological stage between normal ageing (NA) and Alzheimer's disease (AD). Although subjects with MCI show a decline at different rates, some individuals remain stable or even show an improvement in their cognitive level after some years. We assessed the accuracy of FDG PET in discriminating MCI patients who converted to AD from those who did not. FDG PET was performed in 42 NA subjects, 27 MCI patients who had not converted to AD at 5 years (nc-MCI; mean follow-up time 7.5 ± 1.5 years), and 95 MCI patients who converted to AD within 5 years (MCI-AD; mean conversion time 1.8 ± 1.1 years). Relative FDG uptake values in 26 meta-volumes of interest were submitted to ANCOVA and support vector machine analyses to evaluate regional differences and discrimination accuracy. The MCI-AD group showed significantly lower FDG uptake values in the temporoparietal cortex than the other two groups. FDG uptake values in the nc-MCI group were similar to those in the NA group. Support vector machine analysis discriminated nc-MCI from MCI-AD patients with an accuracy of 89% (AUC 0.91), correctly detecting 93% of the nc-MCI patients. In MCI patients not converting to AD within a minimum follow-up time of 5 years and MCI patients converting within 5 years, baseline FDG PET and volume-based analysis identified those who converted with an accuracy of 89%. However, further analysis is needed in patients with amnestic MCI who convert to a dementia other than AD. (orig.)

  10. Multimodal Hyper-connectivity Networks for MCI Classification.

    Science.gov (United States)

    Li, Yang; Gao, Xinqiang; Jie, Biao; Yap, Pew-Thian; Kim, Min-Jeong; Wee, Chong-Yaw; Shen, Dinggang

    2017-09-01

    Hyper-connectivity network is a network where every edge is connected to more than two nodes, and can be naturally denoted using a hyper-graph. Hyper-connectivity brain network, either based on structural or functional interactions among the brain regions, has been used for brain disease diagnosis. However, the conventional hyper-connectivity network is constructed solely based on single modality data, ignoring potential complementary information conveyed by other modalities. The integration of complementary information from multiple modalities has been shown to provide a more comprehensive representation about the brain disruptions. In this paper, a novel multimodal hyper-network modelling method was proposed for improving the diagnostic accuracy of mild cognitive impairment (MCI). Specifically, we first constructed a multimodal hyper-connectivity network by simultaneously considering information from diffusion tensor imaging and resting-state functional magnetic resonance imaging data. We then extracted different types of network features from the hyper-connectivity network, and further exploited a manifold regularized multi-task feature selection method to jointly select the most discriminative features. Our proposed multimodal hyper-connectivity network demonstrated a better MCI classification performance than the conventional single modality based hyper-connectivity networks.

  11. Correspondence Management System

    Data.gov (United States)

    U.S. Environmental Protection Agency — CMS is EPA's correspondence tracking and workflow management system. It scans, logs, routes, tracks, and stores incoming and outgoing correspondence in all Program...

  12. Controlled Correspondence Tracking -

    Data.gov (United States)

    Department of Transportation — This data set contains information on external and internal correspondence addressed to the Secretary, Deputy Secretary, or Chief of Staff. Data include information...

  13. Unified correspondence and canonicity

    NARCIS (Netherlands)

    Zhao, Z.

    2018-01-01

    Correspondence theory originally arises as the study of the relation between modal formulas and first-order formulas interpreted over Kripke frames. We say that a modal formula and a first-order formula correspond to each other if they are valid on the same class of Kripke frames. Canonicity theory

  14. Cognitive profiles in Mild Cognitive Impairment (MCI patients associated with Parkinson′s disease and cognitive disorders

    Directory of Open Access Journals (Sweden)

    Michele Pistacchi

    2015-01-01

    Full Text Available Background: Mild cognitive impairment (MCI is rapidly becoming one of the most common clinical manifestations affecting the elderly and represents an heterogeneous clinical syndrome that can be ascribed to different etiologies; the construct of MCI in Parkinson′s disease (PD (MCI-PD is more recent but the range of deficits is still variable. Early recognition and accurate classification of MCI-PD could offer opportunities for novel therapeutic interventions to improve the natural pathologic course. Objective: To investigate the clinical phenotype of amnestic mild cognitive impairment (aMCI and in patients with PD and MCI (MCI-PD. Materials and Methods: Seventy-three patients with aMCI and in 38 patients with MCI-PD were enrolled. They all underwent Mini-mental State Examination (MMSE, the Rey auditory-verbal learning test and the immediate visual memory (IVM item of the Mental Deterioration Battery, the Rey auditory-verbal learning test included the Rey-immediate (Rey-I, and the delayed recall of the word list (Rey test deferred, Rey-D. The Geriatric Depression Scale (GDS was used for mood assessment. Results: The results of the Rey-I and Rey-D and of the IVM item showed statistically significant differences between the aMCI and the MCI-PD group. The mean Rey-I and Rey-D score was significantly lower as well as the IVM score was higher in patients with aMCI than in those with MCI-PD, aMCI patients showed greater impairment in long-term memory, whereas more aMCI than MCI-PD patients had preserved attention, computation, praxis, and conceptualization. Conclusions: Our findings demonstrate that the cognitive deficit profile is specific for each of the two disorders: Memory impairment was a typical feature in aMCI patients while MCI-PD patients suffered from executive functions and visuospatial attention deficits.

  15. Abnormal-induced theta activity supports early directed-attention network deficits in progressive MCI.

    Science.gov (United States)

    Deiber, Marie-Pierre; Ibañez, Vicente; Missonnier, Pascal; Herrmann, François; Fazio-Costa, Lara; Gold, Gabriel; Giannakopoulos, Panteleimon

    2009-09-01

    The electroencephalography (EEG) theta frequency band reacts to memory and selective attention paradigms. Global theta oscillatory activity includes a posterior phase-locked component related to stimulus processing and a frontal-induced component modulated by directed attention. To investigate the presence of early deficits in the directed attention-related network in elderly individuals with mild cognitive impairment (MCI), time-frequency analysis at baseline was used to assess global and induced theta oscillatory activity (4-6Hz) during n-back working memory tasks in 29 individuals with MCI and 24 elderly controls (EC). At 1-year follow-up, 13 MCI patients were still stable and 16 had progressed. Baseline task performance was similar in stable and progressive MCI cases. Induced theta activity at baseline was significantly reduced in progressive MCI as compared to EC and stable MCI in all n-back tasks, which were similar in terms of directed attention requirements. While performance is maintained, the decrease of induced theta activity suggests early deficits in the directed-attention network in progressive MCI, whereas this network is functionally preserved in stable MCI.

  16. Hierarchical anatomical brain networks for MCI prediction: revisiting volumetric measures.

    Directory of Open Access Journals (Sweden)

    Luping Zhou

    Full Text Available Owning to its clinical accessibility, T1-weighted MRI (Magnetic Resonance Imaging has been extensively studied in the past decades for prediction of Alzheimer's disease (AD and mild cognitive impairment (MCI. The volumes of gray matter (GM, white matter (WM and cerebrospinal fluid (CSF are the most commonly used measurements, resulting in many successful applications. It has been widely observed that disease-induced structural changes may not occur at isolated spots, but in several inter-related regions. Therefore, for better characterization of brain pathology, we propose in this paper a means to extract inter-regional correlation based features from local volumetric measurements. Specifically, our approach involves constructing an anatomical brain network for each subject, with each node representing a Region of Interest (ROI and each edge representing Pearson correlation of tissue volumetric measurements between ROI pairs. As second order volumetric measurements, network features are more descriptive but also more sensitive to noise. To overcome this limitation, a hierarchy of ROIs is used to suppress noise at different scales. Pairwise interactions are considered not only for ROIs with the same scale in the same layer of the hierarchy, but also for ROIs across different scales in different layers. To address the high dimensionality problem resulting from the large number of network features, a supervised dimensionality reduction method is further employed to embed a selected subset of features into a low dimensional feature space, while at the same time preserving discriminative information. We demonstrate with experimental results the efficacy of this embedding strategy in comparison with some other commonly used approaches. In addition, although the proposed method can be easily generalized to incorporate other metrics of regional similarities, the benefits of using Pearson correlation in our application are reinforced by the experimental

  17. Complex Correspondence Principle

    International Nuclear Information System (INIS)

    Bender, Carl M.; Meisinger, Peter N.; Hook, Daniel W.; Wang Qinghai

    2010-01-01

    Quantum mechanics and classical mechanics are distinctly different theories, but the correspondence principle states that quantum particles behave classically in the limit of high quantum number. In recent years much research has been done on extending both quantum and classical mechanics into the complex domain. These complex extensions continue to exhibit a correspondence, and this correspondence becomes more pronounced in the complex domain. The association between complex quantum mechanics and complex classical mechanics is subtle and demonstrating this relationship requires the use of asymptotics beyond all orders.

  18. Advance prediction of mild cognitive impairment (MCI) using 99mTc-ECD SPECT brain blood flow imaging

    International Nuclear Information System (INIS)

    Kawasaki, Yohsuke

    2008-01-01

    Mild Cognitive Impairment (MCI) is considered as a precursor state of Alzheimer disease (AD). Single photon emission computed tomography (SPECT) brain blood flow imaging was investigated in MCI and it's relevance to the prognosis of MCI was evaluated in an attempt define the characteristics of brain blood flow imaging of MCI (amnestic MCI; aMCI) converting to AD. Ninety-two patients over 60 years old with amnesia were studied. 99m Tc-ethyl cysteinate dimer (ECD) SPECT brain blood flow examinations of the subject under drug-free conditions were conducted and imaging was analyzed according to the first clinical diagnosis. Patients given a diagnosis of MCI on the first clinical diagnosis, were examined again after 2 years and the SPECT imaging before 2 years previously was classified and analyzed. Of them, there were 35 MCI patients, converting of 13 AD patients (37.1%; aMCI), 10 MCI patients (28.6%; non-converter), 4 depression patients (11.4%; Depression type MCI (dMCI)), 1 Geriatric psychosis patient, but 7 patients dropped out. In the aMCI group, relative hypoperfusion was recognized in the posterior cingulate and the precuneus. In the dMCI group, relative hypoperfusion was recognized in the dorsolateral prefrontal cortex (DLPFC) and the anterior cingulate. In the non-converter group, relative hypoperfusion was recognized in the basal forebrain. The hypoperfusion of the precuneus in aMCI, and the hypoperfusion of the right frontal lobe (DLPFC, dorsal-anterior cingulate) in dMCI were characteristic brain blood-flow abnormalities. We believe 99m Tc-ECD SPECT brain blood flow imaging to be useful in the diagnosis of aMCI and in the early detection of depression. (author)

  19. 18F-FDG PET diagnostic and prognostic patterns do not overlap in Alzheimer's disease (AD) patients at the mild cognitive impairment (MCI) stage

    International Nuclear Information System (INIS)

    Morbelli, Silvia; Bauckneht, Matteo; Buschiazzo, Ambra; Nieri, Alberto; Sambuceti, Gianmario; Pagani, Marco; De Carli, Fabrizio

    2017-01-01

    We aimed to identify the cortical regions where hypometabolism can predict the speed of conversion to dementia in mild cognitive impairment due to Alzheimer's disease (MCI-AD). We selected from the clinical database of our tertiary center memory clinic, eighty-two consecutive MCI-AD that underwent 18F-fluorodeoxyglucose (FDG) PET at baseline during the first diagnostic work-up and were followed up at least until their clinical conversion to AD dementia. The whole group of MCI-AD was compared in SPM8 with a group of age-matched healthy controls (CTR) to verify the presence of AD diagnostic-pattern; then the correlation between conversion time and brain metabolism was assessed to identify the prognostic-pattern. Significance threshold was set at p < 0.05 False-Discovery-Rate (FDR) corrected at peak and at cluster level. Each MCI-AD was then compared with CTR by means of a SPM single-subject analysis and grouped according to presence of AD diagnostic-pattern and prognostic-pattern. Kaplan-Meier-analysis was used to evaluate if diagnostic- and/or prognostic-patterns can predict speed of conversion to dementia. Diagnostic-pattern corresponded to typical posterior hypometabolism (BA 7, 18, 19, 30, 31 and 40) and did not correlate with time to conversion, which was instead correlated with metabolic levels in right middle and inferior temporal gyri as well as in the fusiform gyrus (prognostic-pattern, BA 20, 21 and 38). At Kaplan-Meier analysis, patients with hypometabolism in the prognostic pattern converted to AD-dementia significantly earlier than patients not showing significant hypometabolism in the right middle and inferior temporal cortex (9 versus 19 months; Log rank p < 0.02, Breslow test: p < 0.003, Tarone-Ware test: p < 0.007). The present findings support the role of FDG PET as a robust progression biomarker even in a naturalist population of MCI-AD. However, not the AD-typical diagnostic-pattern in posterior regions but the middle and inferior temporal

  20. 18F-FDG PET diagnostic and prognostic patterns do not overlap in Alzheimer's disease (AD) patients at the mild cognitive impairment (MCI) stage

    Energy Technology Data Exchange (ETDEWEB)

    Morbelli, Silvia; Bauckneht, Matteo; Buschiazzo, Ambra; Nieri, Alberto; Sambuceti, Gianmario [Genoa Univ. (Italy). Dept. of Health Sciences; IRCCS AOU San Martino-IST, Genoa (Italy). Nuclear Medicine Unit; Arnaldi, Dario; Picco, Agnese; Pardini, Matteo; Brugnolo, Andrea; Girtler, Nicola; Nobili, Flavio [Genoa Univ. (Italy). Clinical Neurology, Department of Neuroscience (DINOGMI); IRCCS AOU San Martino-IST, Genoa (Italy); Pagani, Marco [Institute of Cognitive Sciences and Technologies, Rome (Italy); Karolinska Hospital, Stockholm (Sweden). Department of Nuclear Medicine; Chincarini, Andrea [Istituto Nazionale di Fisica Nucleare, Genoa (Italy); De Carli, Fabrizio [National Research Council, Genoa (Italy). Institute of Bioimaging and Molecular Physiology

    2017-11-15

    We aimed to identify the cortical regions where hypometabolism can predict the speed of conversion to dementia in mild cognitive impairment due to Alzheimer's disease (MCI-AD). We selected from the clinical database of our tertiary center memory clinic, eighty-two consecutive MCI-AD that underwent 18F-fluorodeoxyglucose (FDG) PET at baseline during the first diagnostic work-up and were followed up at least until their clinical conversion to AD dementia. The whole group of MCI-AD was compared in SPM8 with a group of age-matched healthy controls (CTR) to verify the presence of AD diagnostic-pattern; then the correlation between conversion time and brain metabolism was assessed to identify the prognostic-pattern. Significance threshold was set at p < 0.05 False-Discovery-Rate (FDR) corrected at peak and at cluster level. Each MCI-AD was then compared with CTR by means of a SPM single-subject analysis and grouped according to presence of AD diagnostic-pattern and prognostic-pattern. Kaplan-Meier-analysis was used to evaluate if diagnostic- and/or prognostic-patterns can predict speed of conversion to dementia. Diagnostic-pattern corresponded to typical posterior hypometabolism (BA 7, 18, 19, 30, 31 and 40) and did not correlate with time to conversion, which was instead correlated with metabolic levels in right middle and inferior temporal gyri as well as in the fusiform gyrus (prognostic-pattern, BA 20, 21 and 38). At Kaplan-Meier analysis, patients with hypometabolism in the prognostic pattern converted to AD-dementia significantly earlier than patients not showing significant hypometabolism in the right middle and inferior temporal cortex (9 versus 19 months; Log rank p < 0.02, Breslow test: p < 0.003, Tarone-Ware test: p < 0.007). The present findings support the role of FDG PET as a robust progression biomarker even in a naturalist population of MCI-AD. However, not the AD-typical diagnostic-pattern in posterior regions but the middle and inferior temporal

  1. Rotation in correspondence analysis

    NARCIS (Netherlands)

    van de Velden, Michel; Kiers, Henk A.L.

    2005-01-01

    In correspondence analysis rows and columns of a nonnegative data matrix are depicted as points in a, usually, two-dimensional plot. Although such a two-dimensional plot often provides a reasonable approximation, the situation can occur that an approximation of higher dimensionality is required.

  2. The Bohr Correspondence Principle

    Indian Academy of Sciences (India)

    IAS Admin

    Deepak Dhar. Keywords. Correspondence principle, hy- drogen atom, Kepler orbit. Deepak Dhar works at the. Tata Institute of Funda- mental Research,. Mumbai. His research interests are mainly in the area of statistical physics. We consider the quantum-mechanical non-relati- vistic hydrogen atom. We show that for bound.

  3. Characterizing brain patterns in conversion from mild cognitive impairment (MCI) to Alzheimer's disease

    Science.gov (United States)

    Silva R., Santiago S.; Giraldo, Diana L.; Romero, Eduardo

    2017-11-01

    Structural Magnetic Resonance (MR) brain images should provide quantitative information about the stage and progression of Alzheimer's disease. However, the use of MRI is limited and practically reduced to corroborate a diagnosis already performed with neuropsychological tools. This paper presents an automated strategy for extraction of relevant anatomic patterns related with the conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) using T1-weighted MR images. The process starts by representing each of the possible classes with models generated from a linear combination of volumes. The difference between models allows us to establish which are the regions where relevant patterns might be located. The approach searches patterns in a space of brain sulci, herein approximated by the most representative gradients found in regions of interest defined by the difference between the linear models. This hypothesis is assessed by training a conventional SVM model with the found relevant patterns under a leave-one-out scheme. The resultant AUC was 0.86 for the group of women and 0.61 for the group of men.

  4. Predicting Stability of Mild Cognitive Impairment (MCI): Findings of a Community Based Sample

    NARCIS (Netherlands)

    Ellendt, S.; Vobeta, B.; Kohn, N.; Wagels, L.; Goerlich, K.S.; Drexler, E.; Schneider, F.; Habel, U.

    2017-01-01

    BACKGROUND: Mild Cognitive Impairment (MCI) is a risk factor for Alzheimer's disease (AD) and other forms of dementia. However, much heterogeneity concerning neuropsychological measures, prevalence and progression rates impedes distinct diagnosis and treatment implications. OBJECTIVE: Aim of the

  5. Correspondences. Equivalence relations

    International Nuclear Information System (INIS)

    Bouligand, G.M.

    1978-03-01

    We comment on sections paragraph 3 'Correspondences' and paragraph 6 'Equivalence Relations' in chapter II of 'Elements de mathematique' by N. Bourbaki in order to simplify their comprehension. Paragraph 3 exposes the ideas of a graph, correspondence and map or of function, and their composition laws. We draw attention to the following points: 1) Adopting the convention of writting from left to right, the composition law for two correspondences (A,F,B), (U,G,V) of graphs F, G is written in full generality (A,F,B)o(U,G,V) = (A,FoG,V). It is not therefore assumed that the co-domain B of the first correspondence is identical to the domain U of the second (EII.13 D.7), (1970). 2) The axiom of choice consists of creating the Hilbert terms from the only relations admitting a graph. 3) The statement of the existence theorem of a function h such that f = goh, where f and g are two given maps having the same domain (of definition), is completed if h is more precisely an injection. Paragraph 6 considers the generalisation of equality: First, by 'the equivalence relation associated with a map f of a set E identical to (x is a member of the set E and y is a member of the set E and x:f = y:f). Consequently, every relation R(x,y) which is equivalent to this is an equivalence relation in E (symmetrical, transitive, reflexive); then R admits a graph included in E x E, etc. Secondly, by means of the Hilbert term of a relation R submitted to the equivalence. In this last case, if R(x,y) is separately collectivizing in x and y, theta(x) is not the class of objects equivalent to x for R (EII.47.9), (1970). The interest of bringing together these two subjects, apart from this logical order, resides also in the fact that the theorem mentioned in 3) can be expressed by means of the equivalence relations associated with the functions f and g. The solutions of the examples proposed reveal their simplicity [fr

  6. Awareness of deficits in mild cognitive impairment and Alzheimer's disease: do MCI patients have impaired insight

    DEFF Research Database (Denmark)

    Vogel, Asmus; Stokholm, Jette; Gade, Anders

    2004-01-01

    In this study we investigated impaired awareness of cognitive deficits in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Very few studies have addressed this topic, and methodological inconsistencies make the comparison of previous studies difficult. From a prospective...... heterogeneity in the clinical presentation of awareness. The results demonstrate that subjective memory problems should not be a mandatory prerequisite in suspected dementia or MCI, which makes reports from informants together with thorough clinical interview and observation central when assessing suspected...

  7. High Blood Caffeine Levels in MCI Linked to Lack of Progression to Dementia

    Science.gov (United States)

    Cao, Chuanhai; Loewenstein, David A.; Lin, Xiaoyang; Zhang, Chi; Wang, Li; Duara, Ranjan; Wu, Yougui; Giannini, Alessandra; Bai, Ge; Cai, Jianfeng; Greig, Maria; Schofield, Elizabeth; Ashok, Raj; Small, Brent; Potter, Huntington; Arendash, Gary W.

    2017-01-01

    Although both human epidemiologic and animal model studies have suggested that caffeine/coffee protects against Alzheimer’s disease, direct human evidence for this premise has been lacking. In the present case-control study, two separate cohorts consisting of 124 total individuals (65–88 years old) were cognitively assessed and a blood sample taken for caffeine/biomarker analysis. Subjects were then monitored for cognitive status over the ensuing 2–4 year period to determine the extent to which initial plasma caffeine/biomarkers levels would be predictive of changes in cognitive status. Plasma caffeine levels at study onset were substantially lower (−51%) in mild cognitive impairment (MCI) subjects who later progressed to dementia (MCI→DEM) compared to levels in stable MCI subjects (MCI→MCI). Moreover, none of the MCI→DEM subjects had initial blood caffeine levels that were above a critical level of 1200 ng/ml, while half of stable MCI→MCI subjects had blood caffeine levels higher than that critical level. Thus, plasma caffeine levels greater than 1200 ng/ml (≈6 µM) in MCI subjects were associated with no conversion to dementia during the ensuing 2–4 year follow-up period. Among the 11 cytokines measured in plasma, three of them (GCSF, IL-10, and IL-6) were decreased in MCI→DEM subjects, but not in stable MCI→MCI subjects with high plasma caffeine levels. Coffee would appear to be the major or perhaps only source of caffeine for such stable MCI patients. This case-control study provides the first direct evidence that caffeine/coffee intake is associated with a reduced risk of dementia or delayed onset, particularly for those who already have MCI. PMID:22430531

  8. Altered causal connectivity of resting state brain networks in amnesic MCI.

    Directory of Open Access Journals (Sweden)

    Peipeng Liang

    Full Text Available Most neuroimaging studies of resting state networks in amnesic mild cognitive impairment (aMCI have concentrated on functional connectivity (FC based on instantaneous correlation in a single network. The purpose of the current study was to investigate effective connectivity in aMCI patients based on Granger causality of four important networks at resting state derived from functional magnetic resonance imaging data--default mode network (DMN, hippocampal cortical memory network (HCMN, dorsal attention network (DAN and fronto-parietal control network (FPCN. Structural and functional MRI data were collected from 16 aMCI patients and 16 age, gender-matched healthy controls. Correlation-purged Granger causality analysis was used, taking gray matter atrophy as covariates, to compare the group difference between aMCI patients and healthy controls. We found that the causal connectivity between networks in aMCI patients was significantly altered with both increases and decreases in the aMCI group as compared to healthy controls. Some alterations were significantly correlated with the disease severity as measured by mini-mental state examination (MMSE, and California verbal learning test (CVLT scores. When the whole-brain signal averaged over the entire brain was used as a nuisance co-variate, the within-group maps were significantly altered while the between-group difference maps did not. These results suggest that the alterations in causal influences may be one of the possible underlying substrates of cognitive impairments in aMCI. The present study extends and complements previous FC studies and demonstrates the coexistence of causal disconnection and compensation in aMCI patients, and thus might provide insights into biological mechanism of the disease.

  9. A Robotic Solution for Assisting People with MCI at Home: Preliminary Tests of the ENRICHME System.

    Science.gov (United States)

    Salatino, Claudia; Pigini, Lucia; Van Kol, Marlies Maria Elisabeth; Gower, Valerio; Andrich, Renzo; Munaro, Giulia; Rosso, Roberto; Castellani, Angelo P; Farina, Elisabetta

    2017-01-01

    Robots have the potential to support care and independence of older adults. The ENRICHME project is developing an integrated system composed of a robot, sensors and a networking care platform, aiming at assisting older adults with MCI in their home environment. This paper reports findings of the tests performed on a sample of MCI users and their caregivers, with the first version of the ENRICHME system, in a controlled environment.

  10. Comparative evaluation of the two methods of fixed dose radioiodine therapy (5 mCi and 10 mCi) for the treatment of Graves' disease

    International Nuclear Information System (INIS)

    Fard Esfehani, A.; Dabbagh Kakhki, V.R.; Eftekhari, M.; Zarpak, B.; Fallahi Seyjani, B.; Saghari, M.

    2002-01-01

    Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment in most patients with Graves' disease. Due to complexity of methods for dose determination, the tendency is toward using fixed doses of I-131 for this purpose. As there is conflict for the best fixed dose, regarding it's efficiency and complication of hypothyroidism, standardized dose selection is of particular importance in treatment of Grave' disease. 59 patients with grave' disease, referred to the nuclear medicine center of Shariati Hospital from 78.5.25 were studied. In this clinical trial, the patients were randomized into two groups, one were treated with 5 mCi of 1-131 and the other received 10 mCi of the same agent. All patients were followed for two years, with 6-month intervals. Among 65 patients treated with I-131, 20 (33 9%) patients became euthyroid and 19(32.2%) became hypothyroid while relapse was noticed in 20 patients (33.9%) In The group treated by 5 mCi I-131 (33 patients), 10(30%) were euthyroid, 6(18.2%) were hypothyroid (overall cure of 48.5% while 17(51.5%) remained hyperthyroid by the end of the follow -up period(two years). From the 26 patients who were treated with 10 mCi, the euthyroid, hypothyroid and hypothyroid states were observed in 10(38.5%), 13(50%), 13(50%) and 3(11.5%) patients respectively (with an overall cure rate of 88.5%). No relationship was noted between the outcome and age, sex, size of the thyroid gland and thyroid uptake, but the relationship between the disease outcome and the amount of administered radioiodine was statistically significant (P=0.003). For most of the patients, age, sex, iodine uptake and even thyroid size play minor roles in dose selection. Although the incidence-rate of early hypothyroidism (by the end of 2 years) in the cases related with 5 mCi is less than those treated with 10 mCi, the incidence of relapse is greatly higher in the former group. In addition, it was found that long

  11. Disrupted Structural Brain Network in AD and aMCI: A Finding of Long Fiber Degeneration.

    Science.gov (United States)

    Fang, Rong; Yan, Xiao-Xiao; Wu, Zhi-Yuan; Sun, Yu; Yin, Qi-Hua; Wang, Ying; Tang, Hui-Dong; Sun, Jun-Feng; Miao, Fei; Chen, Sheng-Di

    2015-01-01

    Although recent evidence has emerged that Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) patients show both regional brain abnormalities and topological degeneration in brain networks, our understanding of the effects of white matter fiber aberrations on brain network topology in AD and aMCI is still rudimentary. In this study, we investigated the regional volumetric aberrations and the global topological abnormalities in AD and aMCI patients. The results showed a widely distributed atrophy in both gray and white matters in the AD and aMCI groups. In particular, AD patients had weaker connectivity with long fiber length than aMCI and normal control (NC) groups, as assessed by fractional anisotropy (FA). Furthermore, the brain networks of all three groups exhibited prominent economical small-world properties. Interestingly, the topological characteristics estimated from binary brain networks showed no significant group effect, indicating a tendency of preserving an optimal topological architecture in AD and aMCI during degeneration. However, significantly longer characteristic path length was observed in the FA weighted brain networks of AD and aMCI patients, suggesting dysfunctional global integration. Moreover, the abnormality of the characteristic path length was negatively correlated with the clinical ratings of cognitive impairment. Thus, the results therefore suggested that the topological alterations in weighted brain networks of AD are induced by the loss of connectivity with long fiber lengths. Our findings provide new insights into the alterations of the brain network in AD and may indicate the predictive value of the network metrics as biomarkers of disease development.

  12. Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment (MCI during Episodic Memory Encoding

    Directory of Open Access Journals (Sweden)

    Shannon L Risacher

    2013-09-01

    Full Text Available Objective: To determine the physiological impact of treatment with donepezil (Aricept on neural circuitry supporting episodic memory encoding in patients with amnestic mild cognitive impairment (MCI using functional MRI (fMRI. Methods: 18 patients with MCI and 20 age-matched healthy controls (HC were scanned twice while performing an event-related verbal episodic encoding task. MCI participants were scanned before treatment and after approximately 3 months on donepezil; HC were untreated but rescanned at the same interval. Voxel-level analyses assessed treatment effects in activation profile relative to retest changes in non-treated HC. Changes in task-related connectivity in medial temporal circuitry were also evaluated, as were associations between brain activation pattern, task-related functional connectivity, task performance, and clinical measures of cognition.Results: At baseline, the MCI group showed reduced activation during encoding relative to HC in the right medial temporal lobe (MTL; hippocampal/parahippocampal and additional regions, as well as attenuated task-related deactivation, relative to rest, in a medial parietal lobe cluster. After treatment, the MCI group showed normalized MTL activation and improved parietal deactivation. These changes were associated with cognitive performance. After treatment, the MCI group also demonstrated increased task-related functional connectivity from the right MTL cluster seed region to a network of other sites including the basal nucleus/caudate and bilateral frontal lobes. Increased functional connectivity was associated with improved task performance.Conclusions: Pharmacologic enhancement of cholinergic function in amnestic MCI is associated with changes in brain activation pattern and functional connectivity during episodic memory processing which are in turn related to increased cognitive performance. fMRI is a promising biomarker for assessing treatment related changes in brain function.

  13. The Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): an expansion of the ADAS-Cog to improve responsiveness in MCI.

    Science.gov (United States)

    Skinner, Jeannine; Carvalho, Janessa O; Potter, Guy G; Thames, April; Zelinski, Elizabeth; Crane, Paul K; Gibbons, Laura E

    2012-12-01

    The Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-Cog) is widely used in AD, but may be less responsive to change when used in people with mild cognitive impairment (MCI). Participants from the Alzheimer's Disease Neuroimaging Initiative were administered a neuropsychological battery and 1.5 T MRI scans over 2-3 years. Informants were queried regarding functional impairments. Some participants had lumbar punctures to obtain cerebrospinal fluid (CSF). We added executive functioning (EF) and functional ability (FA) items to the ADAS-Cog to generate candidate augmented measures. We calibrated these candidates using baseline data (n = 811) and selected the best candidate that added EF items alone and that added EF and FA items. We selected candidates based on their responsiveness over three years in a training sample of participants with MCI (n = 160). We compared traditional ADAS-Cog scores with the two candidates based on their responsiveness in a validation sample of participants with MCI (n = 234), ability to predict conversion to dementia (n = 394), strength of association with baseline MRI (n = 394) and CSF biomarkers (n = 193). The selected EF candidate added category fluency (ADAS Plus EF), and the selected EF and FA candidate added category fluency, Digit Symbol, Trail Making, and five items from the Functional Assessment Questionnaire (ADAS Plus EF&FA). The ADAS Plus EF& FA performed as well as or better than traditional ADAS-Cog scores. Adding EF and FA items to the ADAS-Cog may improve responsiveness among people with MCI without impairing validity.

  14. Cognitive reserve moderates the association between functional network anti-correlations and memory in MCI.

    Science.gov (United States)

    Franzmeier, Nicolai; Buerger, Katharina; Teipel, Stefan; Stern, Yaakov; Dichgans, Martin; Ewers, Michael

    2017-02-01

    Cognitive reserve (CR) shows protective effects on cognitive function in older adults. Here, we focused on the effects of CR at the functional network level. We assessed in patients with amnestic mild cognitive impairment (aMCI) whether higher CR moderates the association between low internetwork cross-talk on memory performance. In 2 independent aMCI samples (n = 76 and 93) and healthy controls (HC, n = 36), CR was assessed via years of education and intelligence (IQ). We focused on the anti-correlation between the dorsal attention network (DAN) and an anterior and posterior default mode network (DMN), assessed via sliding time window analysis of resting-state functional magnetic resonance imaging (fMRI). The DMN-DAN anti-correlation was numerically but not significantly lower in aMCI compared to HC. However, in aMCI, lower anterior DMN-DAN anti-correlation was associated with lower memory performance. This association was moderated by CR proxies, where the association between the internetwork anti-correlation and memory performance was alleviated at higher levels of education or IQ. In conclusion, lower DAN-DMN cross-talk is associated with lower memory in aMCI, where such effects are buffered by higher CR. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI.

    Science.gov (United States)

    Caroli, Anna; Prestia, Annapaola; Wade, Sara; Chen, Kewei; Ayutyanont, Napatkamon; Landau, Susan M; Madison, Cindee M; Haense, Cathleen; Herholz, Karl; Reiman, Eric M; Jagust, William J; Frisoni, Giovanni B

    2015-01-01

    The aim of this study was to compare the performance and power of the best-established diagnostic biological markers as outcome measures for clinical trials in patients with mild cognitive impairment (MCI). Magnetic resonance imaging, F-18 fluorodeoxyglucose positron emission tomography markers, and Alzheimer's Disease Assessment Scale-cognitive subscale were compared in terms of effect size and statistical power over different follow-up periods in 2 MCI groups, selected from Alzheimer's Disease Neuroimaging Initiative data set based on cerebrospinal fluid (abnormal cerebrospinal fluid Aβ1-42 concentration-ABETA+) or magnetic resonance imaging evidence of Alzheimer disease (positivity to hippocampal atrophy-HIPPO+). Biomarkers progression was modeled through mixed effect models. Scaled slope was chosen as measure of effect size. Biomarkers power was estimated using simulation algorithms. Seventy-four ABETA+ and 51 HIPPO+ MCI patients were included in the study. Imaging biomarkers of neurodegeneration, especially MR measurements, showed highest performance. For all biomarkers and both MCI groups, power increased with increasing follow-up time, irrespective of biomarker assessment frequency. These findings provide information about biomarker enrichment and outcome measurements that could be employed to reduce MCI patient samples and treatment duration in future clinical trials.

  16. The role of the DLPFC in inductive reasoning of MCI patients and normal agings: an fMRI study.

    Science.gov (United States)

    Yang, YanHui; Liang, PeiPeng; Lu, ShengFu; Li, KunCheng; Zhong, Ning

    2009-08-01

    Previous studies of young people have revealed that the left dorsolateral prefrontal cortex (DLPFC) plays an important role in inductive reasoning. An fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal aging, and whether the activation pattern of this region was different between MCI patients and normal aging. The fMRI results indicated that MCI patients had no difference from normal aging in behavior performance (reaction time and accuracy) and the activation pattern of DLPFC. However, the BOLD response of the DLPFC region for MCI patients was weaker than that for normal aging, and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal aging. Taken together, these results indicated that DLPFC plays an important role in inductive reasoning of aging, and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.

  17. Multi-task linear programming discriminant analysis for the identification of progressive MCI individuals.

    Directory of Open Access Journals (Sweden)

    Guan Yu

    Full Text Available Accurately identifying mild cognitive impairment (MCI individuals who will progress to Alzheimer's disease (AD is very important for making early interventions. Many classification methods focus on integrating multiple imaging modalities such as magnetic resonance imaging (MRI and fluorodeoxyglucose positron emission tomography (FDG-PET. However, the main challenge for MCI classification using multiple imaging modalities is the existence of a lot of missing data in many subjects. For example, in the Alzheimer's Disease Neuroimaging Initiative (ADNI study, almost half of the subjects do not have PET images. In this paper, we propose a new and flexible binary classification method, namely Multi-task Linear Programming Discriminant (MLPD analysis, for the incomplete multi-source feature learning. Specifically, we decompose the classification problem into different classification tasks, i.e., one for each combination of available data sources. To solve all different classification tasks jointly, our proposed MLPD method links them together by constraining them to achieve the similar estimated mean difference between the two classes (under classification for those shared features. Compared with the state-of-the-art incomplete Multi-Source Feature (iMSF learning method, instead of constraining different classification tasks to choose a common feature subset for those shared features, MLPD can flexibly and adaptively choose different feature subsets for different classification tasks. Furthermore, our proposed MLPD method can be efficiently implemented by linear programming. To validate our MLPD method, we perform experiments on the ADNI baseline dataset with the incomplete MRI and PET images from 167 progressive MCI (pMCI subjects and 226 stable MCI (sMCI subjects. We further compared our method with the iMSF method (using incomplete MRI and PET images and also the single-task classification method (using only MRI or only subjects with both MRI and

  18. Multi-task linear programming discriminant analysis for the identification of progressive MCI individuals.

    Science.gov (United States)

    Yu, Guan; Liu, Yufeng; Thung, Kim-Han; Shen, Dinggang

    2014-01-01

    Accurately identifying mild cognitive impairment (MCI) individuals who will progress to Alzheimer's disease (AD) is very important for making early interventions. Many classification methods focus on integrating multiple imaging modalities such as magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET). However, the main challenge for MCI classification using multiple imaging modalities is the existence of a lot of missing data in many subjects. For example, in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, almost half of the subjects do not have PET images. In this paper, we propose a new and flexible binary classification method, namely Multi-task Linear Programming Discriminant (MLPD) analysis, for the incomplete multi-source feature learning. Specifically, we decompose the classification problem into different classification tasks, i.e., one for each combination of available data sources. To solve all different classification tasks jointly, our proposed MLPD method links them together by constraining them to achieve the similar estimated mean difference between the two classes (under classification) for those shared features. Compared with the state-of-the-art incomplete Multi-Source Feature (iMSF) learning method, instead of constraining different classification tasks to choose a common feature subset for those shared features, MLPD can flexibly and adaptively choose different feature subsets for different classification tasks. Furthermore, our proposed MLPD method can be efficiently implemented by linear programming. To validate our MLPD method, we perform experiments on the ADNI baseline dataset with the incomplete MRI and PET images from 167 progressive MCI (pMCI) subjects and 226 stable MCI (sMCI) subjects. We further compared our method with the iMSF method (using incomplete MRI and PET images) and also the single-task classification method (using only MRI or only subjects with both MRI and PET images

  19. Visualizing stages of cortical atrophy in progressive MCI from the ADNI cohort

    DEFF Research Database (Denmark)

    Eskildsen, Simon Fristed; Fonov, Vladimir; Coupé, Pierrick

    Amnestic mild cognitive impairment (MCI) is considered a condition where patients are at risk of developing clinically definite Alzheimer’s disease (AD) with an annual conversion rate of approximately 15%[1]. AD is characterized by progressive brain atrophy with major impact on the cerebral cortex...... and visualize the cortical atrophy at different stages in patients who eventually converted to clinically definite AD. We selected patients with a diagnosis of MCI from the ADNI database who converted to AD during the follow-up period. T1-weighted MRI scans were collected at time of conversion(n=140...

  20. MOTORES DE COMBUSTIÓN INTERNA (MCI) OPERANDO CON MEZCLAS DE ETANOL GASOLINA: REVISIÓN

    OpenAIRE

    Garcia Mariaca, Alexander; Cendales Ladino, Edwin Darío; Eslava Sarmiento, Andrés Felipe

    2016-01-01

    En este artículo se presenta una revisión bibliográfica acerca del uso de etanol como combustible en motores de combustión interna de encendido provocado (MCI-EP). Este empieza por una breve descripción de las diversas formas de producción y principales productores en el mundo de etanol, para posteriormente profundizar en el desempeño, combustión y las emisiones en MCI-EP al operar con diferentes mezclas de etanol y gasolina convencional. Los resultados obtenidos por los diferentes autores de...

  1. Monte-Carlo Impurity transport simulations in the edge of the DIII-D tokamak using the MCI code

    International Nuclear Information System (INIS)

    Evans, T.E.; Mahdavi, M.A.; Sager, G.T.; West, W.P.; Fenstermacher, M.E.; Meyer, W.H.; Porter, G.D.

    1995-07-01

    A Monte-Carlo Impurity (MCI) transport code is used to follow trace impurities through multiple ionization states in realistic 2-D tokamak geometries. The MCI code is used to study impurity transport along the open magnetic field lines of the Scrape-off Layer (SOL) and to understand how impurities get into the core from the SOL. An MCI study concentrating on the entrainment of carbon impurities ions by deuterium background plasma into the DIII-D divertor is discussed. MCI simulation results are compared to experimental DIII-D carbon measurements

  2. Monte-Carlo Impurity transport simulations in the edge of the DIII-D tokamak using the MCI code

    International Nuclear Information System (INIS)

    Evans, T.E.; Sager, G.T.; Mahdavi, M.A.; Porter, G.D.; Fenstermacher, M.E.; Meyer, W.H.

    1995-01-01

    A Monte-Carlo Impurity (MCI) transport code is used to follow trace impurities through multiple ionization states in realistic 2-D tokamak geometries. The MCI code is used to study impurity transport along the open magnetic field lines of the Scrape-off Layer (SOL) and to understand how impurities get into the core from the SOL. An MCI study concentrating on the entrainment of carbon impurities ions by deuterium background plasma into the DII-D divertor is discussed. MCI simulation results are compared to experimental DII-D carbon measurements. 2 refs

  3. Selective Changes of Resting-State Brain Oscillations in aMCI: An fMRI Study Using ALFF

    Directory of Open Access Journals (Sweden)

    Zhilian Zhao

    2014-01-01

    Full Text Available Mild cognitive impairment (MCI refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual’s age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI most often leads to Alzheimer’s disease. This study aims to elucidate the altered brain activation in patients with aMCI using resting-state functional magnetic resonance. We observed Frequency-dependent changes in the amplitude of low-frequency fluctuations in aMCI patients (n=20, and normal subjects (n=18. At the same time, we took gray matter volume as a covariate. We found that aMCI patients had decreased amplitude of low-frequency fluctuation signal in left superior temporal gyrus, right middle temporal gyrus, right inferior parietal lobe, and right postcentral gyrus compared to the control group. Specially, aMCI patients showed increased signal in left superior and middle frontal gyrus. Our results suggested that increased activation in frontal lobe of aMCI patients may indicate effective recruitment of compensatory brain resources. This finding and interpretation may lead to the better understanding of cognitive changes of aMCI.

  4. Correspondence

    African Journals Online (AJOL)

    raoul

    2011-12-14

    Dec 14, 2011 ... achieved in Africa without an adequate health workforce [1]. ... capacity, African countries will be unable to build and use disease surveillance ..... Laboratory epidemiologist: skilled partner in field epidemiology and disease ...

  5. Correspondence

    African Journals Online (AJOL)

    employees, and their primary obligation is to patients who use public medical services. It is therefore sheer ... state employees, some at senior consultant level, who run full-on single-handed private practices, ... altered, this must be done through proper engagement and negotiation. To do otherwise sets a dangerous ...

  6. Correspondence

    African Journals Online (AJOL)

    Finally, SAMA remains deeply concerned about the sensationalist way in which the media and government alike are dealing with this matter. Generalisations are being made and doctors are being vilified by forensic reports without the courtesy of engaging with or informing SAMA. Equally, if high-ranking officials and MECs ...

  7. CORRESPONDENCE

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    efficient healthcare across the world. The use of medical ... technologies, and particularly on the availability of specific medical devices, policies ... management of medical devices, as well as the absence of a regulatory environment, are major ...

  8. Correspondence

    African Journals Online (AJOL)

    raoul

    2011-12-14

    Dec 14, 2011 ... 11Tanzania Ministry of Health and Social Welfare, P.O. Box 9083, Dar es Salam, Tanzania, 2African Field Epidemiology Network P.O. Box 12874,. Kampala, Uganda .... oversee research activities for the students and provide expertise in abstract and manuscript writing. NIMR provides the base of ...

  9. Correspondence

    African Journals Online (AJOL)

    ebutamanya

    2015-07-30

    Jul 30, 2015 ... goal of the H3A is to use data obtained from research efforts to influence and inform strategies that will address .... challenges associated with obtaining a valid informed consent [24,. 25]. Genetic studies are extremely ... Multidisciplinary approach is the silver lining in the dark cloud that has befallen genetic ...

  10. CORRESPONDENCE

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    [1] The treatment rate in 2012 for the public sector is essentially unchanged at 73 pmp, compared with 620 pmp (of insured persons) in the private sector. In ... of different ethnic groups, with a 64% increase in black patients accessing RRT since ...

  11. CORRESPONDENCE

    African Journals Online (AJOL)

    monitors, in keeping with international quality assurance require- ments. .... reference to locally advanced breast cancer. World J Surg ... Results of an audit of mammography in women younger than 40 in a resource restricted environment.

  12. CORRESPONDENCE

    African Journals Online (AJOL)

    The article claims to explore parents' views on the HIV counselling and testing campaign to be conducted in high schools, within an interpretative qualitative paradigm. This is an interesting and important topic. However, the methodology of the study is deeply flawed and unfortunately gives qualitative research a bad name.

  13. Correspondence

    African Journals Online (AJOL)

    A new algorithm for the diagnosis of all forms of tuberculosis is required for. South Africa. To the Editor: I write in response to 'Diagnosing Xpert MTB/RIF- negative TB: Impact and cost of alternative algorithms for South. Africa' published in the SAMJ in February 2013.[1]. Modelling the impact and cost of alternative algorithms ...

  14. Correspondence

    African Journals Online (AJOL)

    is itself reasonable, fair and ethical. Clearly, there are glaring deficiencies in the existing coding and billing structure that do not allow for the addition of codes applicable to new procedures. Equally importantly, intertwined with a coding structure, is the billing structure. Each code has a unit value and each unit a Rand value, ...

  15. CORRESPONDENCE

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    for subsets of CDs are often interpreted as the totality of CDs when it is not the case. If single-gene disorders, accounting for 30.0% of CDs. (B Modell − personal communication, 2016), were pooled with con- genital abnormalities in the study by Reid et al.,[1] a greater proportion of under-5 deaths may be attributed to CDs.

  16. Correspondence

    African Journals Online (AJOL)

    of paediatric beds is about 40 km away, and there is no formal public transport or railway link between Mzamomhle and the hospital. In response to ... We present our positive experience as a motivation for other junior health ... All it takes is a.

  17. CORRESPONDENCE

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    conflict of interest (CoI) is a growing problem in medical publi cations.[1] The critique ... For example, different sources cite academic commitments, personal relationships ... ecigarettes and the adoption of sugarsweetened beverage taxes, we.

  18. CORRESPONDENCE

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    REDS-II Donor Iron Status Evaluation (RISE) study documents that among frequent US ... [3] We were unable to find data on the prevalence of ... fatal myocardial infarction and stroke. ... had donated an average of 119 units of blood per individual (range ... patient when the 'regular blood donor' explanation is accepted as the.

  19. CORRESPONDENCE

    African Journals Online (AJOL)

    regular blood donation on iron stores, and consequent risks of iron depletion and iron deficiency anaemia. There is little doubt that frequent blood donation may result in reduced iron stores. It is also important to note that haemoglobin (Hb) levels may remain relatively normal in spite of reduced iron stores, although changes.

  20. CORRESPONDENCE

    African Journals Online (AJOL)

    airborne allergens, which may lead to the onset of rhinitis, pneumonia or asthma. Patients with these respiratory conditions often develop a cough, which is responsible for increased abdominal pressure. The latter promotes visceral protrusion through the collar of the hernia, and causes discomfort. The loop continues to ...

  1. CORRESPONDENCE

    African Journals Online (AJOL)

    Recommendations for the handling of fluorescent lamps in public schools in. Johannesburg, South Africa. To the Editor: Fluorescent lamps are regarded as hazardous waste because of their mercury content.[1] Mercury has toxic properties that may have acute or chronic detrimental impacts on human health and the ...

  2. Predicting the time of conversion to MCI in the elderly: role of verbal expression and learning.

    Science.gov (United States)

    Oulhaj, Abderrahim; Wilcock, Gordon K; Smith, A David; de Jager, Celeste A

    2009-11-03

    Increasing awareness that minimal or mild cognitive impairment (MCI) in the elderly may be a precursor of dementia has led to an increase in the number of people attending memory clinics. We aimed to develop a way of predicting the period of time before cognitive impairment occurs in community-dwelling elderly. The method is illustrated by the use of simple tests of different cognitive domains. A cohort of 241 normal elderly volunteers was followed for up to 20 years with regular assessments of cognitive abilities using the Cambridge Cognitive Examination (CAMCOG); 91 participants developed MCI. We used interval-censored survival analysis statistical methods to model which baseline cognitive tests best predicted the time to convert to MCI. Out of several baseline variables, only age and CAMCOG subscores for expression and learning/memory were predictors of the time to conversion. The time to conversion was 14% shorter for each 5 years of age, 17% shorter for each point lower in the expression score, and 15% shorter for each point lower in the learning score. We present in tabular form the probability of converting to MCI over intervals between 2 and 10 years for different combinations of expression and learning scores. In apparently normal elderly people, subtle measurable cognitive deficits that occur within the normal range on standard testing protocols reliably predict the time to clinically relevant cognitive impairment long before clinical symptoms are reported.

  3. Quantitative comparisons between experimentally measured 2-D carbon radiation and Monte Carlo impurity (MCI) code simulations

    International Nuclear Information System (INIS)

    Evans, T.E.; Leonard, A.W.; West, W.P.; Finkenthal, D.F.; Fenstermacher, M.E.; Porter, G.D.

    1998-08-01

    Experimentally measured carbon line emissions and total radiated power distributions from the DIII-D divertor and Scrape-Off Layer (SOL) are compared to those calculated with the Monte Carlo Impurity (MCI) model. A UEDGE background plasma is used in MCI with the Roth and Garcia-Rosales (RG-R) chemical sputtering model and/or one of six physical sputtering models. While results from these simulations do not reproduce all of the features seen in the experimentally measured radiation patterns, the total radiated power calculated in MCI is in relatively good agreement with that measured by the DIII-D bolometric system when the Smith78 physical sputtering model is coupled to RG-R chemical sputtering in an unaltered UEDGE plasma. Alternatively, MCI simulations done with UEDGE background ion temperatures along the divertor target plates adjusted to better match those measured in the experiment resulted in three physical sputtering models which when coupled to the RG-R model gave a total radiated power that was within 10% of measured value

  4. Oxygen-saving effect of a new cardiotonic agent, MCI-154, in diseased human hearts.

    Science.gov (United States)

    Mori, M; Takeuchi, M; Takaoka, H; Hata, K; Hayashi, Y; Yamakawa, H; Yokoyama, M

    1997-03-01

    The aim of this study was to examine the left ventricular mechanoenergetic effects of a novel Ca2+ sensitizing agent, MCI-154, on diseased human hearts compared with dobutamine. Unlike conventional cardiotonic agents, a Ca2+ sensitizer that could produce a positive inotropic action by altering the responsiveness of myofilament to Ca2+ could generate force with smaller amounts of Ca2+; thus, it may potentially save energy expenditure. The left ventricular pressure-volume relation and myocardial oxygen consumption per beat (Vo2) were measured by a conductance (volume) catheter and a Webster catheter. Left ventricular contractility (Emax), systolic pressure-volume area (PVA [index of left ventricular total mechanical energy]) and Vo2 were assessed before and after infusion of MCI-154 or dobut-amine. The PVA-independent Vo2 (Vo2 mainly for excitation-contraction coupling) was assessed as the Vo2 at zero PVA. Both agents increased Emax comparably (dobutamine: from 3.55 +/- 1.10 [mean +/- SD] to 5.04 +/- 1.16 mm Hg/ml per m2, p delta PVA-independent Vo2/delta Emax) was less with MCI-154 than with dobutamine (0.14 +/- 0.18 vs. 1.10 +/- 0.80 J/mm Hg per ml per m2, p action mediated by MCI-154 could provide an energetic advantage over the conventional cardiotonic action with currently used inotropic agents.

  5. 1H-Magnetic resonance spectroscopy in Mb. Alzheimer's and MCI patients

    International Nuclear Information System (INIS)

    Fankhauser, M.

    2009-01-01

    In this study a proton magnetic spectroscopy was conducted on 38 patients suffering from Alzheimer, 10 patients with MCI (mild cognitive impairment) and 21 elderly controls. The analyzed metabolites were N-acetyl-aspartate (NAA), creatine (Cr), choline (Cho) and myo-Inositol (Ins). 1 H-MRS was conducted in the cingulated gyri and the centrum semiovale of 38 patients with AD, 10 patients with MCI and 21 elderly controls. A STEAM sequence was used at 1,5 Tesla. The values of NAA, Cho, Cr and Ins were measured and the ratios of NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were statistically evaluated. The Ins/Cr Ratio in the posterior cingulated gyrus was significantly lower in the MCI group than in the DAT group (p=0,007), while the decrease of the Ins/Cr Ratio in the compared controls was not significant. The NAA/Cr ratio was not significantly different whether in patients with AD, MCI nor in the examined controls. NAA/Cho and Cho/Cr ratios were likewise not significantly different in the three groups. Our findings of an increased Ins/Cr Ratio in the AD group might indicate the beginning of glial activation in the posterior cingulated gyri. As the other examined ratios were not significantly different among the three groups, our patients may not have suffered significant neuronal loss yet. (author) [de

  6. Integrative EEG biomarkers predict progression to Alzheimer's disease at the MCI stage

    Directory of Open Access Journals (Sweden)

    Simon-Shlomo ePoil

    2013-10-01

    Full Text Available Alzheimer's disease (AD is a devastating disorder of increasing prevalence in modern society. Mild cognitive impairment (MCI is considered a transitional stage between normal aging and AD; however, not all subjects with MCI progress to AD. Prediction of conversion to AD at an early stage would enable an earlier, and potentially more effective, treatment of AD. Electroencephalography (EEG biomarkers would provide a non-invasive and relatively cheap screening tool to predict conversion to AD; however, traditional EEG biomarkers have not been considered accurate enough to be useful in clinical practice. Here, we aim to combine the information from multiple EEG biomarkers into a diagnostic classification index in order to improve the accuracy of predicting conversion from MCI to AD within a two-year period. We followed 86 patients initially diagnosed with MCI for two years during which 25 patients converted to AD. We show that multiple EEG biomarkers mainly related to activity in the beta-frequency range (13–30 Hz can predict conversion from MCI to AD. Importantly, by integrating six EEG biomarkers into a diagnostic index using logistic regression the prediction improved compared with the classification using the individual biomarkers, with a sensitivity of 88% and specificity of 82%, compared with a sensitivity of 64% and specificity of 62% of the best individual biomarker in this index. In order to identify this diagnostic index we developed a data mining approach implemented in the Neurophysiological Biomarker Toolbox (http://www.nbtwiki.net/. We suggest that this approach can be used to identify optimal combinations of biomarkers (integrative biomarkers also in other modalities. Potentially, these integrative biomarkers could be more sensitive to disease progression and response to therapeutic intervention.

  7. Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer's disease?

    Science.gov (United States)

    Visser, P; Scheltens, P; Verhey, F

    2005-01-01

    Background: Drugs effective in Alzheimer-type dementia have been tested in subjects with mild cognitive impairment (MCI) because these are supposed to have Alzheimer's disease in the predementia stage. Objectives: To investigate whether MCI criteria used in these drug trials can accurately diagnose subjects with predementia Alzheimer's disease. Methods: MCI criteria of the Gal-Int 11 study, InDDEx study, ADCS memory impairment study, ampakine CX 516 study, piracetam study, and Merck rofecoxib study were applied retrospectively in a cohort of 150 non-demented subjects from a memory clinic. Forty two had progressed to Alzheimer type dementia during a five year follow up period and were considered to have predementia Alzheimer's disease at baseline. Outcome measures were the odds ratio, sensitivity, specificity, and positive and negative predictive value. Results: The odds ratio of the MCI criteria for predementia Alzheimer's disease varied between 0.84 and 11. Sensitivity varied between 0.46 and 0.83 and positive predictive value between 0.43 and 0.76. None of the criteria combined a high sensitivity with a high positive predictive value. Exclusion criteria for depression led to an increase in positive predictive value and specificity at the cost of sensitivity. In subjects older than 65 years the positive predictive value was higher than in younger subjects. Conclusions: The diagnostic accuracy of MCI criteria used in trials for predementia Alzheimer's disease is low to moderate. Their use may lead to inclusion of many patients who do not have predementia Alzheimer's disease or to exclusion of many who do. Subjects with moderately severe depression should not be excluded from trials in order not to reduce the sensitivity. PMID:16170074

  8. Five-year follow-up of 11C-PIB uptake in Alzheimer's disease and MCI

    International Nuclear Information System (INIS)

    Kemppainen, N.M.; Scheinin, N.M.; Koivunen, J.; Johansson, J.; Toivonen, J.T.; Naagren, K.; Rokka, J.; Rinne, J.O.; Karrasch, M.; Parkkola, R.

    2014-01-01

    The aim of this study was to evaluate the longitudinal changes in [ 11 C]PIB uptake in mild cognitive impairment (MCI) and Alzheimer's disease (AD) over a long-term follow-up. Six AD patients, ten MCI patients and eight healthy subjects underwent a [ 11 C]PIB PET scan at baseline and at 2 and 5 years. The clinical status of the MCI patients was evaluated every 6 months. The MCI group showed a significant increase in [ 11 C]PIB uptake over time (p 11 C]PIB scan at baseline but increased uptake later. There was an increase in [ 11 C]PIB uptake with time in the AD group (p = 0.02), but this did not significantly differ from the change in the control group. Our results revealed a significant increase in amyloid load even at the time of AD diagnosis in some of the MCI patients who converted. A positive [ 11 C]PIB scan at baseline in MCI patients strongly predicted future conversion to AD but a negative PIB scan in MCI patients did not exclude future conversion. The results suggest that there is wide individual variation in the brain amyloid load in MCI, and in the course of amyloid accumulation in relation to the clinical diagnosis of AD. (orig.)

  9. Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI

    Directory of Open Access Journals (Sweden)

    Shankar Tumati

    2018-04-01

    Full Text Available Apathy is a common symptom in patients with amnestic mild cognitive impairment (aMCI and is associated with an increased risk of progression to Alzheimer’s disease (AD. The neural substrates underlying apathy in aMCI may involve multiple brain regions, including the anterior cingulate cortex and the temporo-parietal region. Here we investigated neurometabolites in brain regions that may underlie apathy in aMCI patients using proton magnetic resonance spectroscopy (1H-MRS. Twenty-eight aMCI patients with varying degrees of apathy and 20 matched controls underwent 1H-MRS. Spectra were acquired from single voxels in the posterior cingulate cortex (PCC, dorsal anterior cingulate cortex (DACC, right dorsolateral prefrontal cortex (DLPFC, and right temporo-parietal cortex (TPC. Apathy was measured with the Apathy Evaluation Scale (AES. Spearman partial correlations between metabolite concentrations in each region and severity of apathy were determined. Additionally, analyses of covariance (ANCOVA were performed to determine whether metabolite changes differed between patients with or without clinically-diagnosed apathy. The degree of apathy was found to be negatively correlated with choline and myo-inositol (mI in the TPC. Additional exploratory analyses suggested that N-acetylaspartate (NAA/mI ratio was reduced in aMCI without clinical apathy but not in aMCI with clinical apathy. In the DACC, glutamate and glutamine (Glx levels tended to be higher in the aMCI with apathy group compared to controls and reduced in association with depression scores. In conclusion, apathy in aMCI patients was associated with neurometabolite changes indicative of altered membranal integrity and glial function in the right TPC. Findings also indicated that in a clinically-diagnosed aMCI cohort, apathy symptoms may be suggestive of neural changes that are distinct from aMCI without apathy.

  10. Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI.

    Science.gov (United States)

    Tumati, Shankar; Opmeer, Esther M; Marsman, Jan-Bernard C; Martens, Sander; Reesink, Fransje E; De Deyn, Peter P; Aleman, André

    2018-01-01

    Apathy is a common symptom in patients with amnestic mild cognitive impairment (aMCI) and is associated with an increased risk of progression to Alzheimer's disease (AD). The neural substrates underlying apathy in aMCI may involve multiple brain regions, including the anterior cingulate cortex and the temporo-parietal region. Here we investigated neurometabolites in brain regions that may underlie apathy in aMCI patients using proton magnetic resonance spectroscopy ( 1 H-MRS). Twenty-eight aMCI patients with varying degrees of apathy and 20 matched controls underwent 1 H-MRS. Spectra were acquired from single voxels in the posterior cingulate cortex (PCC), dorsal anterior cingulate cortex (DACC), right dorsolateral prefrontal cortex (DLPFC), and right temporo-parietal cortex (TPC). Apathy was measured with the Apathy Evaluation Scale (AES). Spearman partial correlations between metabolite concentrations in each region and severity of apathy were determined. Additionally, analyses of covariance (ANCOVA) were performed to determine whether metabolite changes differed between patients with or without clinically-diagnosed apathy. The degree of apathy was found to be negatively correlated with choline and myo-inositol (mI) in the TPC. Additional exploratory analyses suggested that N-acetylaspartate (NAA)/mI ratio was reduced in aMCI without clinical apathy but not in aMCI with clinical apathy. In the DACC, glutamate and glutamine (Glx) levels tended to be higher in the aMCI with apathy group compared to controls and reduced in association with depression scores. In conclusion, apathy in aMCI patients was associated with neurometabolite changes indicative of altered membranal integrity and glial function in the right TPC. Findings also indicated that in a clinically-diagnosed aMCI cohort, apathy symptoms may be suggestive of neural changes that are distinct from aMCI without apathy.

  11. Analysis of factors affecting the outcome of Graves disease patients treated with two regimens of fixed Iodine-131 doses (10 mCi and 15 mCi)

    International Nuclear Information System (INIS)

    Machado, Ana C.B.; Santos, Roberto B.; Chaves, Fatima R.; Romaldini, Joao H.; Ward, Laura S.

    2005-01-01

    Full text: The use of fixed doses of radioiodine ( 131 I) simplifies the approach to treatment for Graves' disease (GD) patients with potential cost savings. In order to evaluate factors that may affect the outcome of 2 different regimens of 131 I, we prospectively examined 128 patients with overt thyrotoxicosis from GD, as confirmed by suppressed serum TSH, presence of TRAb, increased serum T 3 and FT 4 values. Group 1 comprised 76 patients who received a fixed dose of 10 mCi and Group 2=52 patients who received a fixed dose of 15 mCi. 36 patients did not use any antithyroid drugs and 92 patients used methimazole that was withdrawn at least 5 days before radioiodine administration. Antithyroid drugs treatment was restarted at least 7 days following 131 I therapy when needed. Baseline serum TSH and FT 4 levels were measured at 3, 6, 9 and 12 months after treatment. The groups were similar concerning age, gender, smoke, eye disease, goiter size, serum T 3 , FT 4 , TRAb, anti-Tg and anti-TPO levels as well as 24-hour 131 I or Tec-uptake values and thyroid scan. Clinical outcome was evaluated at the end of 1-year follow-up and cure of hyperthyroidism was defined as clinical and laboratory evidence of either euthyroidism or hypothyroidism in the absence of antithyroid drugs. The cure rate obtained was similar in groups 1 and 2: 73.7% and 80.8%, respectively (p=0.35). Hypothyroidism was diagnosed in 56.5% and 71.15% of the patients from groups 1 and 2, respectively (p=0.13). There was no correlation between clinical features, thyroid uptake, antibodies, serum hormones and outcome. However, logistic regression analysis demonstrated that patients with larger thyroids (weight >60 g) that, consequently, received a lower dose of radioiodine in MBq/g, had 2.4 times less chance to cure (95% Cl=1.18-4.96). The use of fixed doses of radioiodine ( 131 I) simplifies the approach to treatment for Graves' disease (GD) patients with potential cost savings. In order to evaluate

  12. Revisiting Ethics in Correspondence Testing

    OpenAIRE

    Zschirnt, Eva

    2017-01-01

    Questions of research ethics always arise when planning a correspondence test to study discrimination in the market place. However, the issue is addressed relatively little in published correspondence tests with authors usually referring to the two seminal articles written in this field (i.e. Banton (1997) and Riach and Rich (2004)). Since then correspondence testing has become more widespread and the technique is increasingly relying on the internet to find and send applications. It is there...

  13. Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients

    Directory of Open Access Journals (Sweden)

    João Guilherme Fiorani Borgio

    2012-11-01

    Full Text Available OBJECTIVE: To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB and hippocampal volume (HV as predictors of conversion from mild cognitive impairment (MCI to dementia. METHODS: Twenty-eight individuals (9 normal and 19 with MCI were classified according to their CDR sum of boxes scores into 3 groups. RESULTS: The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups. CONCLUSION: We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.

  14. Amnestic MCI Patients' Perspectives toward Disclosure of Amyloid PET Results in a Research Context.

    Science.gov (United States)

    Vanderschaeghe, Gwendolien; Schaeverbeke, Jolien; Vandenberghe, Rik; Dierickx, Kris

    2017-01-01

    Researchers currently are not obligated to share individual research results (IRR) with participants. This non-disclosure policy has been challenged on the basis of participants' rights to be aware and in control of their personal medical information. Here, we determined how patients view disclosure of research PET results of brain amyloid and why they believe it is advantageous or disadvantageous to disclose. As a part of a larger diagnostic trial, we conducted semi-structured interviews with patients with amnestic Mild Cognitive Impairment (aMCI). Participants had the option to receive their brain amyloid PET scan result (i.e., their IRR). Interviews were conducted before they received their IRR. A total of 38 aMCI patients (100% of study participants) wanted to know their IRR. The two most frequently mentioned reasons for choosing IRR disclosure were to better understand their brain health status and to be better able to make informed decisions about future personal arrangements (e.g., inheritance tax, moving into a smaller house, end-of-life decisions, etc.). Emotional risk was mentioned as the primary disadvantage of knowing one's IRR. On the other hand, non-disclosure was considered to be emotionally difficult also, as patients would be uncertain about their future health condition. Many patients diagnosed clinically with aMCI want to know their brain amyloid test results, even though this knowledge may be disadvantageous to them. Knowing what is going on with their health and the ability to make informed decisions about their future were the two principal advantages mentioned for obtaining their amyloid PET results. Because of the overwhelming consensus of aMCI patients was to disclose their brain amyloid PET scan results, researchers should strongly consider releasing this information to research subjects.

  15. Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients

    Energy Technology Data Exchange (ETDEWEB)

    Brendel, Matthias; Xiong, Guoming; Delker, Andreas [University of Munich, Department of Nuclear Medicine, Munich (Germany); Pogarell, Oliver [University of Munich, Department of Psychiatry, Munich (Germany); Bartenstein, Peter; Rominger, Axel [University of Munich, Department of Nuclear Medicine, Munich (Germany); Munich Cluster for Systems Neurology (SyNergy), Munich (Germany); Collaboration: for the Alzheimer' s Disease Neuroimaging Initiative

    2015-04-01

    Late-life depression even in subsyndromal stages is strongly associated with Alzheimer's disease (AD). Furthermore, brain amyloidosis is an early biomarker in subjects who subsequently suffer from AD and can be sensitively detected by amyloid PET. Therefore, we aimed to compare amyloid load and glucose metabolism in subsyndromally depressed subjects with mild cognitive impairment (MCI). [{sup 18}F]AV45 PET, [{sup 18}F]FDG PET and MRI were performed in 371 MCI subjects from the Alzheimer's Disease Neuroimaging Initiative Subjects were judged β-amyloid-positive (Aβ+; 206 patients) or β-amyloid-negative (Aβ-; 165 patients) according to [{sup 18}F]AV45 PET. Depressive symptoms were assessed by the Neuropsychiatric Inventory Questionnaire depression item 4. Subjects with depressive symptoms (65 Aβ+, 41 Aβ-) were compared with their nondepressed counterparts. Conversion rates to AD were analysed (mean follow-up time 21.5 ± 9.1 months) with regard to coexisting depressive symptoms and brain amyloid load. Aβ+ depressed subjects showed large clusters with a higher amyloid load in the frontotemporal and insular cortices (p < 0.001) with coincident hypermetabolism (p < 0.001) in the frontal cortices than nondepressed subjects. Faster progression to AD was observed in subjects with depressive symptoms (p < 0.005) and in Aβ+ subjects (p < 0.001). Coincident depressive symptoms additionally shortened the conversion time in all Aβ+ subjects (p < 0.005) and to a greater extent in those with a high amyloid load (p < 0.001). Our results clearly indicate that Aβ+ MCI subjects with depressive symptoms have an elevated amyloid load together with relative hypermetabolism of connected brain areas compared with cognitively matched nondepressed individuals. MCI subjects with high amyloid load and coexistent depressive symptoms are at high risk of faster conversion to AD. (orig.)

  16. Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients

    International Nuclear Information System (INIS)

    Brendel, Matthias; Xiong, Guoming; Delker, Andreas; Pogarell, Oliver; Bartenstein, Peter; Rominger, Axel

    2015-01-01

    Late-life depression even in subsyndromal stages is strongly associated with Alzheimer's disease (AD). Furthermore, brain amyloidosis is an early biomarker in subjects who subsequently suffer from AD and can be sensitively detected by amyloid PET. Therefore, we aimed to compare amyloid load and glucose metabolism in subsyndromally depressed subjects with mild cognitive impairment (MCI). [ 18 F]AV45 PET, [ 18 F]FDG PET and MRI were performed in 371 MCI subjects from the Alzheimer's Disease Neuroimaging Initiative Subjects were judged β-amyloid-positive (Aβ+; 206 patients) or β-amyloid-negative (Aβ-; 165 patients) according to [ 18 F]AV45 PET. Depressive symptoms were assessed by the Neuropsychiatric Inventory Questionnaire depression item 4. Subjects with depressive symptoms (65 Aβ+, 41 Aβ-) were compared with their nondepressed counterparts. Conversion rates to AD were analysed (mean follow-up time 21.5 ± 9.1 months) with regard to coexisting depressive symptoms and brain amyloid load. Aβ+ depressed subjects showed large clusters with a higher amyloid load in the frontotemporal and insular cortices (p < 0.001) with coincident hypermetabolism (p < 0.001) in the frontal cortices than nondepressed subjects. Faster progression to AD was observed in subjects with depressive symptoms (p < 0.005) and in Aβ+ subjects (p < 0.001). Coincident depressive symptoms additionally shortened the conversion time in all Aβ+ subjects (p < 0.005) and to a greater extent in those with a high amyloid load (p < 0.001). Our results clearly indicate that Aβ+ MCI subjects with depressive symptoms have an elevated amyloid load together with relative hypermetabolism of connected brain areas compared with cognitively matched nondepressed individuals. MCI subjects with high amyloid load and coexistent depressive symptoms are at high risk of faster conversion to AD. (orig.)

  17. CSF Aβ1-42, but not p-Tau181, differentiates aMCI from SCI.

    Science.gov (United States)

    Rizzi, Liara; Maria Portal, Marcelle; Batista, Carlos Eduardo Alves; Missiaggia, Luciane; Roriz-Cruz, Matheus

    2018-01-01

    Individuals with amnestic mild cognitive impairment (aMCI) are at a high risk to develop Alzheimer's disease (AD). We compared CSF levels of biomarkers of amyloidosis (Aβ 1-42 ) and neurodegeneration (p-Tau 181 ) in individuals with aMCI and with subjective cognitive impairment (SCI) in order to ascertain diagnostic accuracy and predict the odds ratio associated with aMCI. We collected CSF of individuals clinically diagnosed with aMCI (33) and SCI (12) of a memory clinic of Southern Brazil. Levels of Aβ 1-42 and p-Tau 181 were measured by immunoenzymatic assay. Participants also underwent neuropsychological testing including the verbal memory test subscore of the Consortium to Establish a Registry for Alzheimer's Disease (VM-CERAD). CSF concentration of Aβ 1-42 was significantly lower (p: .007) and p-Tau 181 /Aβ 1-42 ratio higher (p: .014) in aMCI individuals than in SCI. However, isolate p-Tau 181 levels were not associated with aMCI (p: .166). There was a statistically significant association between Aβ 1-42 and p-Tau 181 (R 2 : 0.177; β: -4.43; p: .017). ROC AUC of CSF Aβ 1-42 was 0.768 and of the p-Tau 181 /Aβ 1-42 ratio equals 0.742. Individuals with Aβ 1-42   0.071 were at 4.6 increased odds to have aMCI (p: .043), with a 64.5% accuracy. VM-CERAD was significantly lower in aMCI than among SCI (p: .041). CSF Aβ 1-42 , but not p-Tau 181, level was significantly associated with aMCI. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Neurogranin as a predictor of memory and executive function decline in MCI patients.

    Science.gov (United States)

    Headley, Alison; De Leon-Benedetti, Andres; Dong, Chuanhui; Levin, Bonnie; Loewenstein, David; Camargo, Christian; Rundek, Tatjana; Zetterberg, Henrik; Blennow, Kaj; Wright, Clinton B; Sun, Xiaoyan

    2018-03-06

    To determine whether high CSF levels of neurogranin (Ng) predict longitudinal decline in memory and executive function during early-stage Alzheimer disease (AD). Baseline levels of CSF Ng were studied in relation to cross-sectional and longitudinal cognitive performance over 8 years. Data were obtained from the Alzheimer's Disease Neuroimaging Initiative database, and participants with normal cognition (n = 111) and mild cognitive impairment (MCI) (n = 193) were included. High levels of CSF Ng were associated with poor baseline memory scores (β = -0.21, p the rate of decline by tertiles was examined, CSF Ng was a level-dependent predictor of memory function, whereby the group with highest levels of Ng showed the fastest rates of decline in both memory and executive function. When examined separately, elevated Ng was associated with cognitive decline in participants with MCI but not in those with normal cognition. The levels of CSF Ng were not associated with cognitive measures when tau and amyloid 42 (Aβ 42 ) were controlled for in these analyses. High CSF Ng associates with poor memory scores in participants with MCI cross-sectionally and with poor memory and executive function longitudinally. The association of Ng with cognitive measures disappears when tau and Aβ 42 are included in the statistical models. Our findings suggest that CSF Ng may serve as a biomarker of cognition. Synaptic dysfunction contributes to cognitive impairment in early-stage AD. © 2018 American Academy of Neurology.

  19. Cognitive Impairment Questionnaire (CIMP-QUEST): reported topographic symptoms in MCI and dementia.

    Science.gov (United States)

    Astrand, R; Rolstad, S; Wallin, A

    2010-06-01

    The Cognitive Impairment Questionnaire (CIMP-QUEST) is an instrument based on information obtained by key informants to identify symptoms of dementia and dementia-like disorders. The questionnaire consists of three subscales reflecting impairment in parietal-temporal (PT), frontal (F) and subcortical (SC) brain regions. The questionnaire includes a memory scale and lists non-cognitive symptoms. The reliability and validity of the questionnaire were examined in 131 patients with mild cognitive impairment (MCI) or mild dementia at a university-based memory unit. Cronbach alpha for all subscales was calculated at r = 0.90. Factor analysis supported the tri-dimensionality of CIMP-QUEST's brain region-oriented construct. Test-retest reliability for a subgroup of cognitively stable MCI-patients (n = 25) was found to be r = 0.83 (P = 0.0005). The correlation between the score on the cognitive subscales (PT + F + M) and Informant Questionnaire on Cognitive Decline in the Elderly was r = 0.83 (P = 0.0005, n = 123). The memory subscale correlated significantly with episodic memory tests, the PT subscale with visuospatial and language-oriented tests, and the SC and F subscales with tests of attention, psychomotor tempo and executive function. CIMP-QUEST has high reliability and validity, and provides information about cognitive impairment and brain region-oriented symptomatology in patients with MCI and mild dementia.

  20. Contact sensitization to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (MCI/MI). A European multicentre study

    DEFF Research Database (Denmark)

    Menné, T; Frosch, P J; Veien, Niels

    1991-01-01

    , formaldehyde, paraben-mix, and MCI/MI. 19.4% of the patients had positive patch tests to nickel, making this the most common allergen. 3% of the patients reacted to 100 ppm MCI/MI, while 2.6% reacted to formaldehyde and 1.1% to parabens. There was great variation in the frequency of MCI/MI sensitivity among...

  1. Transformation of Correspondence Education into Distance Education

    Directory of Open Access Journals (Sweden)

    Marjan Velej

    1997-12-01

    Full Text Available Since 1957 the Correspondence-Education Centre Univerzum has been involved in correspondence education, which - as a matter of principle - uses the written word as a basic and predorninam medium of instruction, ensuring a two­ directional communication between the teacher and the student. Following the world-wide trends in adult education, the institution has gradually updated its teaching methods by incorporating correspondence-consulting and correspondence-seminar methods. As a result of the forceful development of new technologies and media the written word has become only one among many media of instruction, replacing the concept of correspon­ dence education with that of distance education. Although the latter hasa num­ ber of advantages, it is rather difficult to implement. ln view of its role and in the interese of its own development, the Correspondence-Education Centre Univerzum is forced to effect the transition to distance education. In order to be able to effectively adopt new methods, extensive training has been organised for the teaching staff, the results of which are encouraging. They enable us to plan further changes and improvements of our methods of instruction.

  2. Super boson-fermion correspondence

    International Nuclear Information System (INIS)

    Kac, V.G.; Leur van de, J.W.

    1987-01-01

    Since the pioneering work of Skyrme, the boson-fermion correspondence has been playing an increasingly important role in 2-dimensional quantum field theory. More recently, it has become an important ingredient in the work of the Kyoto school on the KP hierarchy of soliton equations. In the present paper we establish a super boson-fermion correspondence, having in mind its applications to super KP hierarchies

  3. The evaluation of MCI, MI, PMI and GT on both genders with different age and dental status.

    Science.gov (United States)

    Bozdag, G; Sener, S

    2015-01-01

    The aim of this study was to measure the mandibular cortical index (MCI), mental index (MI), panoramic mandibular index (PMI) and cortical bone thickness in the zone of the gonial angle (GT) in panoramic radiographies from a large sample of males and females and to determine how they relate to patients' age, gender and dental status. 910 panoramic radiographs were obtained and grouped into age, dental status and gender. The MCI, MI, PMI and GT were analysed. Remarkable differences were observed for MCI and GT regarding gender, age groups and dental status on both sides (p PMI in females, dental status had an effect on the MI and PMI in males (p PMI (p PMI and MI measurements. The effects of age and tooth loss in the GT and MCI measurements are similar, and these indices can be accepted as more reliable in studies including both genders.

  4. Differences in the use of everyday technology among persons with MCI, SCI and older adults without known cognitive impairment.

    Science.gov (United States)

    Malinowsky, Camilla; Kottorp, Anders; Wallin, Anders; Nordlund, Arto; Björklund, Eva; Melin, Ilse; Pernevik, Anette; Rosenberg, Lena; Nygård, Louise

    2017-07-01

    To use valid subjective reports sensible to cognitive decline is vital to identify very early signs of dementia development. Use of everyday technology (ET) has been shown to be sensitive to differentiate adults with mild cognitive impairment (MCI) from controls, but the group with subjective cognitive impairment (SCI) has not yet been examined. This study aims to investigate and compare self-perceived ability in ET use and number of ETs reported as actually used in a sample of older adults with SCI, MCI, and older adults with no known cognitive impairment, i.e. Older adults with MCI (n = 29), SCI ( n = 26), and controls (n = 30) were interviewed with the short version of the Everyday Technology Use Questionnaire (S-ETUQ) to capture self-perceived ability in ET use and number of ETs used. To generate individual measures of ability to use ET, Rasch analysis was used. The measures were then compared group-wise using ANCOVA. The numbers of ETs used were compared group-wise with ANOVA. Controls versus SCI and MCI differed significantly regarding ETs reported as used, but not SCI versus MCI. Similarly, in ability to use ET, controls versus SCI and MCI differed significantly but not SCI versus MCI. The significantly lower numbers of ETs reported as actually used and the lower ability in SCI and MCI groups compared to controls suggest that ET use is affected already in very minor cognitive decline. This indicates that self-reported ET use based on the S-ETUQ is sensitive to detect changes already in SCI.

  5. Reverters from PD-MCI to cognitively intact are at risk for future cognitive impairment: Analysis of the PPMI cohort.

    Science.gov (United States)

    Jones, Jacob D; Kuhn, Taylor P; Szymkowicz, Sarah M

    2018-02-01

    Past studies have shown that a large portion of individuals with Parkinson's disease (PD) and mild cognitive impairment (MCI) will revert to a cognitively intact (CI) status in the future. Aging studies have shown that individuals who revert from MCI to CI are at increased risk for reconverting to MCI or dementia in the future. The current study examined if individuals who revert from PD-mild cognitive impairment (PD-MCI) to CI will be at increased risk for future PD-MCI and Parkinson's disease dementia (PDD). The study utilized data from the Parkinson's Progression Markers Initiative (PPMI). The sample included 364 newly diagnosed PD participants who were followed annually for up to 4 years. Based on the first and second assessments, we identified individuals who were CI at each assessment (CI-Stable) and individuals who were PD-MCI at baseline but then reverted to CI (Reversion). Analyses examined if participants in the Reversion group were at greater risk, relative to the CI-Stable group, for cognitive impairment at future assessments. Participants in the Reversion group were at greater risk for future cognitive impairment (PD-MCI or PDD) at the 2nd, 3rd and 4th annual follow-up, relative to the CI-Stable group. The Reversion group continued to be at increased risk for future cognitive impairment when adjusting for age, gender, education, depressive symptoms, and motor severity. A large proportion of individuals with PD-MCI will not show evidence of cognitive impairment within a year. However, these "reverters" continue to be at risk for future development of cognitive impairment. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Coherence and phase synchrony analyses of EEG signals in Mild Cognitive Impairment (MCI): A study of functional brain connectivity

    Science.gov (United States)

    Handayani, Nita; Haryanto, Freddy; Khotimah, Siti Nurul; Arif, Idam; Taruno, Warsito Purwo

    2018-03-01

    This paper presents an EEG study for coherence and phase synchrony in mild cognitive impairment (MCI) subjects. MCI is characterized by cognitive decline, which is an early stage of Alzheimer's disease (AD). AD is a neurodegenerative disorder with symptoms such as memory loss and cognitive impairment. EEG coherence is a statistical measure of correlation between signals from electrodes spatially separated on the scalp. The magnitude of phase synchrony is expressed in the phase locking value (PLV), a statistical measure of neuronal connectivity in the human brain. Brain signals were recorded using an Emotiv Epoc 14-channel wireless EEG at a sampling frequency of 128 Hz. In this study, we used 22 elderly subjects consisted of 10 MCI subjects and 12 healthy subjects as control group. The coherence between each electrode pair was measured for all frequency bands (delta, theta, alpha and beta). In the MCI subjects, the value of coherence and phase synchrony was generally lower than in the healthy subjects especially in the beta frequency. A decline of intrahemisphere coherence in the MCI subjects occurred in the left temporo-parietal-occipital region. The pattern of decline in MCI coherence is associated with decreased cholinergic connectivity along the path that connects the temporal, occipital, and parietal areas of the brain to the frontal area of the brain. EEG coherence and phase synchrony are able to distinguish persons who suffer AD in the early stages from healthy elderly subjects.

  7. System Development Guidelines From a Review of Motion-Based Technology for People With Dementia or MCI

    Directory of Open Access Journals (Sweden)

    Arlene J. Astell

    2018-05-01

    Full Text Available As the population ages and the number of people living with dementia or mild cognitive impairment (MCI continues to increase, it is critical to identify creative and innovative ways to support and improve their quality of life. Motion-based technology has shown significant potential for people living with dementia or MCI by providing opportunities for cognitive stimulation, physical activity and participation in meaningful leisure activities, while simultaneously functioning as a useful tool for research and development of interventions. However, many of the current systems created using motion-based technology have not been designed specifically for people with dementia or MCI. Additionally, the usability and accessibility of these systems for these populations has not been thoroughly considered. This paper presents a set of system development guidelines derived from a review of the state of the art of motion-based technologies for people with dementia or MCI. These guidelines highlight three overarching domains of consideration for systems targeting people with dementia or MCI: (i cognitive, (ii physical, and (iii social. We present the guidelines in terms of relevant design and use considerations within these domains and the emergent design themes within each domain. Our hope is that these guidelines will aid in designing motion-based software to meet the needs of people with dementia or MCI such that the potential of these technologies can be realized.

  8. MOTORES DE COMBUSTIÓN INTERNA (MCI) OPERANDO CON MEZCLAS DE ETANOL GASOLINA: REVISIÓN

    OpenAIRE

    Alexander García Mariaca; Edwin Darío Cendales Ladino; Andrés Felipe Eslava Sarmiento

    2016-01-01

    En este artículo se presenta una revisión bibliográfica acerca del uso de etanol como combustible en motores de combustión interna de encendido provocado (MCI-EP). Este empieza por una breve descripción de las diversas formas de producción y principales productores en el mundo de etanol, para posteriormente profundizar en el desempeño, combustión y las emisiones en MCIEP al operar con diferentes mezclas de etanol y gasolina convencional. Los resultados obtenidos por los diferentes autores de ...

  9. Correspondence analysis of longitudinal data

    NARCIS (Netherlands)

    Van der Heijden, P.G.M.|info:eu-repo/dai/nl/073087998

    2005-01-01

    Correspondence analysis is an exploratory tool for the analysis of associations between categorical variables, the results of which may be displayed graphically. For longitudinal data with two time points, an analysis of the transition matrix (showing the relative frequencies for pairs of

  10. Evaluation of radioiodine therapy with fixed doses of 10 and 15 mCi in patients with Graves disease; Avaliacao da radioiodoterapia com doses fixas de 10 e 15 mCi em pacientes com doenca de Graves

    Energy Technology Data Exchange (ETDEWEB)

    Canadas, Viviane; Vilar, Lucio; Moura, Eliane; Brito, Ana; Castellar, Enio [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Hospital das Clinicas. Servico de Endocrinologia]. E-mail: vivi2207@ig.com.br

    2007-10-15

    The treatment options for the hyperthyroidism of Graves' disease are antithyroid drugs, surgery and radioiodine, none of which is considered ideal, as they do not act directly on the etiopathogenesis of the disease. Radioiodine has been increasingly used as the treatment of choice because it is a safe and definitive therapy whose administration is very easy. Some authors prefer to administer higher doses in order to deliberately induce hypothyroidism, while others recommend lower doses that result in a lower incidence of hypothyroidism and a greater incidence of euthyroidism. There is no consensus for the optimal regimen of fixed doses to be used and this is the main focus of the present study, where doses of 10 and 15 mCi of {sup 131}I were compared. Among the 164 patients analyzed, 61 (37.2%) were submitted to 10 mCi and 103 (62.8%) to 15 mCi. In the longitudinal analysis it was observed that remission of the hyperthyroidism was statistically different in the sixth month (p < 0.001), being higher in the group that used the dose of 15 mCi, but similar in both groups at 12 and 24 months. It may be concluded that the administration of fixed doses of 10 and 15 mCi of {sup 131}I brought about a similar remission of the hyperthyroidism after 12 months of treatment. Moreover, the remission rate of the hyperthyroidism had no association with age, sex or previous therapy with antithyroid drugs. (author)

  11. Computing effects for correspondence types

    OpenAIRE

    Hüttel, Hans

    2010-01-01

    We show that type and effect inference is possible for a type and  effect system for authenticity using non-injective correspondences, opponent  types and a spi-calculus with symmetric encryption. We do this by a general  account of how effects can be computed given knowledge of how and where they  appear in type judgments. 

  12. Computing effects for correspondence types

    DEFF Research Database (Denmark)

    Hüttel, Hans

    2010-01-01

    We show that type and effect inference is possible for a type and  effect system for authenticity using non-injective correspondences, opponent  types and a spi-calculus with symmetric encryption. We do this by a general  account of how effects can be computed given knowledge of how and where they......  appear in type judgments. ...

  13. The correspondance of Michael Faraday

    CERN Document Server

    1991-01-01

    The initial volume of the correspondence of Micahel Faraday (1791-1867), published in the year of the bicentenary of his birth, covers his early years up to his discovery of electromagnetic induction in 1831. Other scientific and technical topics covered include Faraday's discovery of electromagnetic rotations (in 1821), the liquefaction of gases (in 1823) and the long series of experiments in the latter part of the 1820s to improve optical glass.

  14. Six psychotropics for pre-symptomatic & early Alzheimer's (MCI, Parkinson's, and Huntington's disease modification

    Directory of Open Access Journals (Sweden)

    Edward C Lauterbach

    2016-01-01

    Full Text Available The quest for neuroprotective drugs to slow the progression of neurodegenerative diseases (NDDs, including Alzheimer's disease (AD, Parkinson's disease (PD, and Huntington's disease (HD, has been largely unrewarding. Preclinical evidence suggests that repurposing quetiapine, lithium, valproate, fluoxetine, donepezil, and memantine for early and pre-symptomatic disease-modification in NDDs may be promising and can spare regulatory barriers. The literature of these psychotropics in early stage and pre-symptomatic AD, PD, and HD is reviewed and propitious findings follow. Mild cognitive impairment (MCI phase of AD: salutary human randomized controlled trial findings for low-dose lithium and, in selected patients, donepezil await replication. Pre-symptomatic AD: human epidemiological data indicate that lithium reduces AD risk. Animal model studies (AMS reveal encouraging results for quetiapine, lithium, donepezil, and memantine. Early PD: valproate AMS findings show promise. Pre-symptomatic PD: lithium and valproate AMS findings are encouraging. Early HD: uncontrolled clinical data indicate non-progression with lithium, fluoxetine, donepezil, and memantine. Pre-symptomatic HD: lithium and valproate are auspicious in AMS. Many other promising findings awaiting replication (valproate in MCI; lithium, valproate, fluoxetine in pre-symptomatic AD; lithium in early PD; lithium, valproate, fluoxetine in pre-symptomatic PD; donepezil in early HD; lithium, fluoxetine, memantine in pre-symptomatic HD are reviewed. Dose- and stage-dependent effects are considered. Suggestions for signal-enhancement in human trials are provided for each NDD stage.

  15. Serial position effects are sensitive predictors of conversion from MCI to Alzheimer's disease dementia.

    Science.gov (United States)

    Egli, Simone C; Beck, Irene R; Berres, Manfred; Foldi, Nancy S; Monsch, Andreas U; Sollberger, Marc

    2014-10-01

    It is unclear whether the predictive strength of established cognitive variables for progression to Alzheimer's disease (AD) dementia from mild cognitive impairment (MCI) varies depending on time to conversion. We investigated which cognitive variables were best predictors, and which of these variables remained predictive for patients with longer times to conversion. Seventy-five participants with MCI were assessed on measures of learning, memory, language, and executive function. Relative predictive strengths of these measures were analyzed using Cox regression models. Measures of word-list position-namely, serial position scores-together with Short Delay Free Recall of word-list learning best predicted conversion to AD dementia. However, only serial position scores predicted those participants with longer time to conversion. Results emphasize that the predictive strength of cognitive variables varies depending on time to conversion to dementia. Moreover, finer measures of learning captured by serial position scores were the most sensitive predictors of AD dementia. Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

  16. Skeletal shape correspondence via entropy minimization

    Science.gov (United States)

    Tu, Liyun; Styner, Martin; Vicory, Jared; Paniagua, Beatriz; Prieto, Juan Carlos; Yang, Dan; Pizer, Stephen M.

    2015-03-01

    Purpose: Improving the shape statistics of medical image objects by generating correspondence of interior skeletal points. Data: Synthetic objects and real world lateral ventricles segmented from MR images. Method(s): Each object's interior is modeled by a skeletal representation called the s-rep, which is a quadrilaterally sampled, folded 2-sided skeletal sheet with spoke vectors proceeding from the sheet to the boundary. The skeleton is divided into three parts: up-side, down-side and fold-curve. The spokes on each part are treated separately and, using spoke interpolation, are shifted along their skeletal parts in each training sample so as to tighten the probability distribution on those spokes' geometric properties while sampling the object interior regularly. As with the surface-based correspondence method of Cates et al., entropy is used to measure both the probability distribution tightness and sampling regularity. The spokes' geometric properties are skeletal position, spoke length and spoke direction. The properties used to measure the regularity are the volumetric subregions bounded by the spokes, their quadrilateral sub-area and edge lengths on the skeletal surface and on the boundary. Results: Evaluation on synthetic and real world lateral ventricles demonstrated improvement in the performance of statistics using the resulting probability distributions, as compared to methods based on boundary models. The evaluation measures used were generalization, specificity, and compactness. Conclusions: S-rep models with the proposed improved correspondence provide significantly enhanced statistics as compared to standard boundary models.

  17. An evaluation of dose/unit area and time as key factors influencing the elicitation capacity of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in MCI/MI-allergic patients

    DEFF Research Database (Denmark)

    Zachariae, Claus; Lerbaek, Anne; McNamee, Pauline M

    2006-01-01

    Methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) contact allergy affects 1-3% of patch-tested patients in European centres. The aim of the present study was to evaluate the importance of the factors--time and concentration (dose/per unit area)--in the elicitation capacity by means...... (2 p.p.m.) of MCI/MI/unit area of the skin for 4 weeks. After a wash-out period of at least 4 weeks, the subjects were exposed to 0.094 microg/cm2 (7.5 p.p.m.) of MCI/MI/unit area of the skin for 4 weeks. The study showed the importance of both time and exposure in the elicitation process...

  18. Post-hoc analysis of randomised, placebo-controlled, double-blind study (MCI186-19) of edaravone (MCI-186) in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Takei, Koji; Takahashi, Fumihiro; Liu, Shawn; Tsuda, Kikumi; Palumbo, Joseph

    2017-10-01

    Post-hoc analyses of the ALS Functional Rating Scale-Revised (ALSFRS-R) score data, the primary endpoint in the 24-week double-blind placebo-controlled study of edaravone (MCI186-19, NCT01492686), were performed to confirm statistical robustness of the result. The previously reported original analysis had used a last observation carried forward (LOCF) method and also excluded patients with fewer than three completed treatment cycles. The post-hoc sensitivity analyses used different statistical methods as follows: 1) including all patients regardless of treatment cycles received (ALL LOCF); 2) a mixed model for repeated measurements (MMRM) analysis; and 3) the Combined Assessment of Function and Survival (CAFS) endpoint. Findings were consistent with the original primary analysis in showing superiority of edaravone over placebo. We also investigated the distribution of change in ALSFRS-R total score across all patients in the study as well as which ALSFRS-R items and domains may have contributed to the overall efficacy findings. The distribution of changes in ALSFRS-R total score from baseline to the end of cycle 6 (ALL LOCF) shifted in favour of edaravone compared to placebo. Edaravone was descriptively favoured for each ALSFRS-R item and each of the four ALSFRS-R domains at the end of cycle 6 (ALL LOCF), suggesting a generalised effect of edaravone in slowing functional decline across all anatomical regions. The effect of edaravone appeared to be similar in patients with bulbar onset and limb onset. Together, these observations would be consistent with its putative neuroprotective effects against the development of oxidative damage unspecific to anatomical regions.

  19. The ADAS-Cog revisited: novel composite scales based on ADAS-Cog to improve efficiency in MCI and early AD trials.

    Science.gov (United States)

    Raghavan, Nandini; Samtani, Mahesh N; Farnum, Michael; Yang, Eric; Novak, Gerald; Grundman, Michael; Narayan, Vaibhav; DiBernardo, Allitia

    2013-02-01

    The Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) has been used widely as a cognitive end point in Alzheimer's Disease (AD) clinical trials. Efforts to treat AD pathology at earlier stages have also used ADAS-Cog, but failure in these trials can be difficult to interpret because the scale has well-known ceiling effects that limit its use in mild cognitive impairment (MCI) and early AD. A wealth of data exists in ADAS-Cog from both historical trials and contemporary longitudinal natural history studies that can provide insights about parts of the scale that may be better suited for MCI and early AD trials. Using Alzheimer's Disease Neuroimaging Initiative study data, we identified the most informative cognitive measures from the ADAS-Cog and other available scales. We used cross-sectional analyses to characterize trajectories of ADAS-Cog and its individual subscales, as well as other cognitive, functional, or global measures across disease stages. Informative measures were identified based on standardized mean of 2-year change from baseline and were combined into novel composite endpoints. We assessed performance of the novel endpoints based on sample size requirements for a 2-year clinical trial. A bootstrap validation procedure was also undertaken to assess the reproducibility of the standardized mean changes of the selected measures and the corresponding composites. All proposed novel endpoints have improved standardized mean changes and thus improved statistical power compared with the ADAS-Cog 11. Further improvements were achieved by using cognitive-functional composites. Combining the novel composites with an enrichment strategy based on cerebral spinal fluid beta-amyloid (Aβ(1-42)) in a 2-year trial yielded gains in power of 20% to 40% over ADAS-Cog 11, regardless of the novel measure considered. An empirical, data-driven approach with existing instruments was used to derive novel composite scales based on ADAS-Cog 11 with improved performance

  20. Type inference for correspondence types

    DEFF Research Database (Denmark)

    Hüttel, Hans; Gordon, Andy; Hansen, Rene Rydhof

    2009-01-01

    We present a correspondence type/effect system for authenticity in a π-calculus with polarized channels, dependent pair types and effect terms and show how one may, given a process P and an a priori type environment E, generate constraints that are formulae in the Alternating Least Fixed......-Point (ALFP) logic. We then show how a reasonable model of the generated constraints yields a type/effect assignment such that P becomes well-typed with respect to E if and only if this is possible. The formulae generated satisfy a finite model property; a system of constraints is satisfiable if and only...... if it has a finite model. As a consequence, we obtain the result that type/effect inference in our system is polynomial-time decidable....

  1. Cytological profile of antibacterial FtsZ inhibitors and synthetic peptide MciZ

    Directory of Open Access Journals (Sweden)

    Lidia Araujo-Bazan

    2016-10-01

    Full Text Available Cell division protein FtsZ is the organizer of the cytokinetic ring in almost all bacteria and a target for the discovery of new antibacterial agents that are needed to counter widespread antibiotic resistance. Bacterial cytological profiling, using quantitative microscopy, is a powerful approach for identifying the mechanism of action of antibacterial molecules affecting different cellular pathways. We have determined the cytological profile on Bacillus subtilis cells of a selection of small molecule inhibitors targeting FtsZ on different binding sites. FtsZ inhibitors lead to long undivided cells, impair the normal assembly of FtsZ into the midcell Z-rings, induce aberrant ring distributions, punctate FtsZ foci, membrane spots and also modify nucleoid length. Quantitative analysis of cell and nucleoid length combined, or the Z-ring distribution, allows categorizing FtsZ inhibitors and to distinguish them from antibiotics with other mechanisms of action, which should be useful for identifying new antibacterial FtsZ inhibitors. Biochemical assays of FtsZ polymerization and GTPase activity combined explain the cellular effects of the FtsZ polymer stabilizing agent PC190723 and its fragments. MciZ is a 40-aminoacid endogenous inhibitor of cell division normally expressed during sporulation in B. subtilis. Using FtsZ cytological profiling we have determined that exogenous synthetic MciZ is an effective inhibitor of B. subtilis cell division, Z-ring formation and localization. This finding supports our cell-based approach to screen for FtsZ inhibitors and opens new possibilities for peptide inhibitors of bacterial cell division.

  2. MOTORES DE COMBUSTIÓN INTERNA (MCI OPERANDO CON MEZCLAS DE ETANOL GASOLINA: REVISIÓN

    Directory of Open Access Journals (Sweden)

    Alexander García Mariaca

    2016-01-01

    Full Text Available En este artículo se presenta una revisión bibliográfica acerca del uso de etanol como combustible en motores de combustión interna de encendido provocado (MCI-EP. Este empieza por una breve descripción de las diversas formas de producción y principales productores en el mundo de etanol, para posteriormente profundizar en el desempeño, combustión y las emisiones en MCIEP al operar con diferentes mezclas de etanol y gasolina convencional. Los resultados obtenidos por los diferentes autores de los parámetros de desempeño, combustión y emisiones, como potencia, torque, presión media efectiva al freno (BME, eficiencia térmica, tasa de liberación de calor, eficiencia de combustión, presión en la cámara de combustión y emisiones reguladas (NOx, THC, CO, CO2 y MP, muestran que el etanol es un excelente comburente para utilizarse en mezcla con gasolina, especialmente en relaciones superiores al 20 % en volumen (E20; debido a que se produce un mejor proceso de combustión causado por el aumento en la cantidad de oxígeno, y se logran así mejoras en los parámetros de desempeño y emisiones del MCI, tales como incrementos en la potencia y la eficiencia térmica y disminución de las emisiones de CO y THC. Sin embargo, se generan aumentos en algunas emisiones contaminantes, como el CO2 y los NOx causados por el exceso de oxígeno en la combustión y el incremento de la temperatura de los gases de escape.

  3. Stereo Correspondence Using Moment Invariants

    Science.gov (United States)

    Premaratne, Prashan; Safaei, Farzad

    Autonomous navigation is seen as a vital tool in harnessing the enormous potential of Unmanned Aerial Vehicles (UAV) and small robotic vehicles for both military and civilian use. Even though, laser based scanning solutions for Simultaneous Location And Mapping (SLAM) is considered as the most reliable for depth estimation, they are not feasible for use in UAV and land-based small vehicles due to their physical size and weight. Stereovision is considered as the best approach for any autonomous navigation solution as stereo rigs are considered to be lightweight and inexpensive. However, stereoscopy which estimates the depth information through pairs of stereo images can still be computationally expensive and unreliable. This is mainly due to some of the algorithms used in successful stereovision solutions require high computational requirements that cannot be met by small robotic vehicles. In our research, we implement a feature-based stereovision solution using moment invariants as a metric to find corresponding regions in image pairs that will reduce the computational complexity and improve the accuracy of the disparity measures that will be significant for the use in UAVs and in small robotic vehicles.

  4. Awareness of memory failures and motivation for cognitive training in mild cognitive impairment.

    Science.gov (United States)

    Werheid, Katja; Ziegler, Matthias; Klapper, Annina; Kühl, Klaus-Peter

    2010-01-01

    Awareness of cognitive deficits is considered to be decisive for the effectiveness of cognitive training in mild cognitive impairment (MCI). However, it is unclear in what way awareness influences motivation to participate in cognitive training. Thirty-two elderly adults with MCI and 72 controls completed the 5-scale Memory Functioning Questionnaire (MFQ) and a motivation questionnaire. The predictive value of the MFQ scales on motivation was analyzed using regression analysis. In the MCI group, but not in controls, higher perceived frequency of memory failures was associated with a lower motivation score. Our findings indicate that, in MCI, greater awareness of cognitive deficits does not necessarily increase motivation to participate in cognitive trainings, and suggest that success expectancy may be a moderating factor. Copyright © 2010 S. Karger AG, Basel.

  5. Correspondence model of occupational accidents

    Directory of Open Access Journals (Sweden)

    Juan C. Conte

    2011-09-01

    Full Text Available We present a new generalized model for the diagnosis and prediction of accidents among the Spanish workforce. Based on observational data of the accident rate in all Spanish companies over eleven years (7,519,732 accidents, we classified them in a new risk-injury contingency table (19×19. Through correspondence analysis, we obtained a structure composed of three axes whose combination identifies three separate risk and injury groups, which we used as a general Spanish pattern. The most likely or frequent relationships between the risk and injuries identified in the pattern facilitated the decision-making process in companies at an early stage of risk assessment. Each risk-injury group has its own characteristics, which are understandable within the phenomenological framework of the accident. The main advantages of this model are its potential application to any other country and the feasibility of contrasting different country results. One limiting factor, however, is the need to set a common classification framework for risks and injuries to enhance comparison, a framework that does not exist today. The model aims to manage work-related accidents automatically at any level.Apresentamos aqui um modelo generalizado para o diagnóstico e predição de acidentes na classe de trabalhadores da Espanha. Baseados em dados sobre a frequência de acidentes em todas as companhias da Espanha em 11 anos (7.519.732 acidentes, nós os classificamos em uma nova tabela de contingência risco-injúria (19×19. Através de uma análise por correspondência obtivemos uma estrutura composta por 3 eixos cuja combinação identifica 3 grupos separados de risco e injúria, que nós usamos como um perfil geral na Espanha. As mais prováveis ou frequentes relações entre risco e injúrias identificadas nesse perfil facilitaram o processo de decisão nas companhias em um estágio inicial de apreciação do risco. Cada grupo de risco-injúria tem suas próprias caracter

  6. An Investigation on the Status of Implementation of Communications and Information Management System (MCI) in Khorasan Razavi Hospitals.

    Science.gov (United States)

    Shojaei, Saeed; Farzianpour, Fereshteh; Arab, Mohammad; Rahimi Foroushani, Abbas

    2015-09-02

    The aim of this investigation is to determine the mean scores of the possibility of implementing the MCI standards in Khorasan Razavi hospitals, from the perspective of Managers, in order to provide a suitable model for evaluating and promoting the system. This was a Research and method (R&D) and Survey Research method, which is of the type of Cross- Sectional, descriptive-analytic Studies conducted in two steps in hospitals of Khorasan Razavi from July to December 2014. This study was approved by the Ethical Committee of Tehran University of Medical Sciences (TUMS) in 2013/6/10. About the nature and purpose of the study was explained to the participants. Were used to apply functional assessment, based on Accreditation Model. In order to collect data, two questionnaires were used, all of which were taken from the standards of MCI. The reliability and validity of the questionnaires were approved by experts.Cronbach's alphas for the questionnaires were obtained to be (0.95, 0.86), respectively. In order to analyze information, statistical analyses, including one way ANOVA, and Independent sample t-test were used. The mean scores of the possibility of implementing the MCI standards in Khorasan Razavi hospitals, were (51.6 and 12.27), respectively. According to half (43.8%) of managers, the MCI standards are applicable in hospitals of Khorasan Razavi; however, their application requires greater efforts by the hospitals.

  7. "You've got a friend in me": can social networks mediate the relationship between mood and MCI?

    Science.gov (United States)

    Yates, Jennifer A; Clare, Linda; Woods, Robert T

    2017-07-13

    Social networks can change with age, for reasons that are adaptive or unwanted. Social engagement is beneficial to both mental health and cognition, and represents a potentially modifiable factor. Consequently this study explored this association and assessed whether the relationship between mild cognitive impairment (MCI) and mood problems was mediated by social networks. This study includes an analysis of data from the Cognitive Function and Ageing Study Wales (CFAS Wales). CFAS Wales Phase 1 data were collected from 2010 to 2013 by conducting structured interviews with older people aged over 65 years of age living in urban and rural areas of Wales, and included questions that assessed cognitive functioning, mood, and social networks. Regression analyses were used to investigate the associations between individual variables and the mediating role of social networks. Having richer social networks was beneficial to both mood and cognition. Participants in the MCI category had weaker social networks than participants without cognitive impairment, whereas stronger social networks were associated with a decrease in the odds of experiencing mood problems, suggesting that they may offer a protective effect against anxiety and depression. Regression analyses revealed that social networks are a significant mediator of the relationship between MCI and mood problems. These findings are important, as mood problems are a risk factor for progression from MCI to dementia, so interventions that increase and strengthen social networks may have beneficial effects on slowing the progression of cognitive decline.

  8. A novel biomarker of amnestic MCI based on dynamic Cross-Frequency Coupling patterns during cognitive brain responses

    Directory of Open Access Journals (Sweden)

    Stavros I Dimitriadis

    2015-10-01

    Full Text Available The detection of mild cognitive impairment (MCI, the transitional stage between normal cognitive changes of aging and the cognitive decline caused by AD, is of paramount clinical importance, since MCI patients are at increased risk of progressing into AD. Electroencephalographic (EEG alterations in the spectral content of brainwaves and connectivity at resting state have been associated with early-stage AD. Recently, cognitive event-related potentials (ERPs have entered into the picture as an easy to perform screening test. Motivated by the recent findings about the role of cross-frequency coupling (CFC in cognition, we introduce a relevant methodological approach for detecting MCI based on cognitive responses from a standard auditory oddball paradigm. By using the single trial signals recorded at Pz sensor and comparing the responses to target and non-target stimuli, we first demonstrate that increased CFC is associated with the cognitive task. Then, considering the dynamic character of CFC, we identify instances during which the coupling between particular pairs of brainwave frequencies carries sufficient information for discriminating between normal subjects and patients with MCI. In this way, we form a multiparametric signature of impaired cognition. The new composite biomarker was tested using data from a cohort that consists of 25 amnestic MCI patients and 15 age-matched controls. Standard machine-learning algorithms were employed so as to implement the binary classification task. Based on leave-one-out cross-validation, the measured classification rate was found reaching very high levels (95%. Our approach compares favorably with the traditional alternative of using the morphology of averaged ERP response to make the diagnosis and the usage of features from spectro-temporal analysis of single-trial response. This further indicates that task-related CFC measurements can provide invaluable analytics in AD diagnosis and prognosis.

  9. Self-awareness of cognitive efficiency: Differences between healthy elderly and patients with mild cognitive impairment (MCI).

    Science.gov (United States)

    Fragkiadaki, Stella; Kontaxopoulou, Dionysia; Beratis, Ion N; Andronas, Nikolaos; Economou, Alexandra; Yannis, George; Papanicolaou, Andrew; Papageorgiou, Sokratis G

    2016-12-01

    Self-estimation of performance implies the ability to understand one's own performance with relatively objective terms. Up to date, few studies have addressed this topic in mild cognitive impairment (MCI) patients. The aim of the present study was to compare objective measures of performance with subjective perception of specific performance on cognitive tests and investigate differences in assessment between MCI patients and healthy elderly. Thirty-five participants diagnosed with MCI (women = 16, men = 19, mean age = 65.09 years ±SD = 7.81, mean education = 12.83 years ±SD = 4.32) and 35 control subjects similar in terms of age and education (women = 20, men = 15, mean age = 62.46 years ± SD = 9.35, mean education = 14.26 ± SD = 2.84) were examined with an extended battery of neuropsychological tests. After every test they were asked to self-evaluate their performance by comparing it to what they considered as average for people of their age and educational level. This self-evaluation was reported on a scale ranging from -100 to +100. Significant differences were found in the self-assessment patterns of the two groups in memory measures of verbal and visual delayed recall, visuospatial perception, and tests of attention. MCI patients overestimated their performance on every cognitive domain while control participants underestimated their performance on measures of verbal memory. The present results indicate that accuracy of self-report is not uniform across groups and functional areas. The discrepancies in the MCI patients indicate unawareness of their memory deficits, which is contradictory to subjective memory complaints as being an important component for clinical diagnosis.

  10. Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy.

    Science.gov (United States)

    Sundermann, Erin E; Biegon, Anat; Rubin, Leah H; Lipton, Richard B; Mowrey, Wenzhu; Landau, Susan; Maki, Pauline M

    2016-04-12

    To examine sex differences in the relationship between clinical symptoms related to Alzheimer disease (AD) (verbal memory deficits) and neurodegeneration (hippocampal volume/intracranial volume ratio [HpVR]) across AD stages. The sample included 379 healthy participants, 694 participants with amnestic mild cognitive impairment (aMCI), and 235 participants with AD and dementia from the Alzheimer's Disease Neuroimaging Initiative who completed the Rey Auditory Verbal Learning Test (RAVLT). Cross-sectional analyses were conducted using linear regression to examine the interaction between sex and HpVR on RAVLT across and within diagnostic groups adjusting for age, education, and APOE ε4 status. Across groups, there were significant sex × HpVR interactions for immediate and delayed recall (p better RAVLT performance was independently associated with female sex (immediate, p = 0.04) and larger HpVR (delayed, p = 0.001). Women showed an advantage in verbal memory despite evidence of moderate hippocampal atrophy. This advantage may represent a sex-specific form of cognitive reserve delaying verbal memory decline until more advanced disease stages. © 2016 American Academy of Neurology.

  11. Music Training Can Improve Music and Speech Perception in Pediatric Mandarin-Speaking Cochlear Implant Users.

    Science.gov (United States)

    Cheng, Xiaoting; Liu, Yangwenyi; Shu, Yilai; Tao, Duo-Duo; Wang, Bing; Yuan, Yasheng; Galvin, John J; Fu, Qian-Jie; Chen, Bing

    2018-01-01

    Due to limited spectral resolution, cochlear implants (CIs) do not convey pitch information very well. Pitch cues are important for perception of music and tonal language; it is possible that music training may improve performance in both listening tasks. In this study, we investigated music training outcomes in terms of perception of music, lexical tones, and sentences in 22 young (4.8 to 9.3 years old), prelingually deaf Mandarin-speaking CI users. Music perception was measured using a melodic contour identification (MCI) task. Speech perception was measured for lexical tones and sentences presented in quiet. Subjects received 8 weeks of MCI training using pitch ranges not used for testing. Music and speech perception were measured at 2, 4, and 8 weeks after training was begun; follow-up measures were made 4 weeks after training was stopped. Mean baseline performance was 33.2%, 76.9%, and 45.8% correct for MCI, lexical tone recognition, and sentence recognition, respectively. After 8 weeks of MCI training, mean performance significantly improved by 22.9, 14.4, and 14.5 percentage points for MCI, lexical tone recognition, and sentence recognition, respectively ( p music and speech performance. The results suggest that music training can significantly improve pediatric Mandarin-speaking CI users' music and speech perception.

  12. Benefits of music training in mandarin-speaking pediatric cochlear implant users.

    Science.gov (United States)

    Fu, Qian-Jie; Galvin, John J; Wang, Xiaosong; Wu, Jiunn-Liang

    2015-02-01

    The aims of this study were to assess young (5- to 10-year-old) Mandarin-speaking cochlear implant (CI) users' musical pitch perception and to assess the benefits of computer-based home training on performance. Melodic contour identification (MCI) was used to assess musical pitch perception in 14 Mandarin-speaking pediatric CI users; the instrument timbre and the contour length were varied as experimental parameters. Six subjects received subsequent MCI training on their home computer in which auditory and visual feedback were provided. MCI performance was generally poor (grand mean=33.3% correct) and highly variable, with scores ranging from 9.3% to 98.1% correct; there was no significant effect of instrument timbre or contour length on performance (p>.05). After 4 weeks of training, performance sharply improved. Follow-up measures that were conducted 8 weeks after training was stopped showed no significant decline in MCI performance. For the 6 trained subjects, there was a significant effect of contour length for the training and follow-up measures. These preliminary data suggest that although baseline MCI performance initially may be poor, training may greatly improve Mandarin-speaking pediatric CI users' melodic pitch perception.

  13. Post-hoc analysis of MCI186-17, the extension study to MCI186-16, the confirmatory double-blind, parallel-group, placebo-controlled study of edaravone in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Takahashi, Fumihiro; Takei, Koji; Tsuda, Kikumi; Palumbo, Joseph

    2017-10-01

    In the 24-week double-blind study of edaravone in ALS (MCI186-16), edaravone did not show a statistically significant difference versus placebo for the primary efficacy endpoint. For post-hoc analyses, two subpopulations were identified in which edaravone might be expected to show efficacy: the efficacy-expected subpopulation (EESP), defined by scores of ≥2 points on all 12 items of the ALS Functional Rating Scale-Revised (ALSFRS-R) and a percent predicted forced vital capacity (%FVC) ≥80% at baseline; and the definite/probable EESP 2 years (dpEESP2y) subpopulation which, in addition to EESP criteria, had definite or probable ALS diagnosed by El Escorial revised criteria, and disease duration of ≤2 years. In the 36-week extension study of MCI186-16, a 24-week double-blind comparison followed by 12 weeks of open-label edaravone (MCI186-17; NCT00424463), analyses of ALSFRS-R scores of the edaravone-edaravone group and edaravone-placebo group for the full analysis set (FAS) and EESP, as prospectively defined, were reported in a previous article. Here we additionally report results in patients who met dpEESP2y criteria at the baseline of MCI186-16. In the dpEESP2y, the difference in ALSFRS-R changes from 24 to 48 weeks between the edaravone-edaravone and edaravone-placebo groups was 2.79 (p = 0.0719), which was greater than the differences previously reported for the EESP and the FAS. The pattern of adverse events in the dpEESP2y did not show any additional safety findings to those from the earlier prospective study. In conclusion, this post-hoc analysis suggests a potential effect of edaravone between 24 and 48 weeks in patients meeting dpEESP2y criteria at baseline.

  14. A Hybrid of Deep Network and Hidden Markov Model for MCI Identification with Resting-State fMRI.

    Science.gov (United States)

    Suk, Heung-Il; Lee, Seong-Whan; Shen, Dinggang

    2015-10-01

    In this paper, we propose a novel method for modelling functional dynamics in resting-state fMRI (rs-fMRI) for Mild Cognitive Impairment (MCI) identification. Specifically, we devise a hybrid architecture by combining Deep Auto-Encoder (DAE) and Hidden Markov Model (HMM). The roles of DAE and HMM are, respectively, to discover hierarchical non-linear relations among features, by which we transform the original features into a lower dimension space, and to model dynamic characteristics inherent in rs-fMRI, i.e. , internal state changes. By building a generative model with HMMs for each class individually, we estimate the data likelihood of a test subject as MCI or normal healthy control, based on which we identify the clinical label. In our experiments, we achieved the maximal accuracy of 81.08% with the proposed method, outperforming state-of-the-art methods in the literature.

  15. Lexical factors and cerebral regions influencing verbal fluency performance in MCI.

    Science.gov (United States)

    Clark, D G; Wadley, V G; Kapur, P; DeRamus, T P; Singletary, B; Nicholas, A P; Blanton, P D; Lokken, K; Deshpande, H; Marson, D; Deutsch, G

    2014-02-01

    To evaluate assumptions regarding semantic (noun), verb, and letter fluency in mild cognitive impairment (MCI) and Alzheimer disease (AD) using novel techniques for measuring word similarity in fluency lists and a region of interest (ROI) analysis of gray matter correlates. Fifty-eight individuals with normal cognition (NC, n=25), MCI (n=23), or AD (n=10) underwent neuropsychological tests, including 10 verbal fluency tasks (three letter tasks [F, A, S], six noun categories [animals, water creatures, fruits and vegetables, tools, vehicles, boats], and verbs). All pairs of words generated by each participant on each task were compared in terms of semantic (meaning), orthographic (spelling), and phonemic (pronunciation) similarity. We used mixed-effects logistic regression to determine which lexical factors were predictive of word adjacency within the lists. Associations between each fluency raw score and gray matter volumes in sixteen ROIs were identified by means of multiple linear regression. We evaluated causal models for both types of analyses to specify the contributions of diagnosis and various mediator variables to the outcomes of word adjacency and fluency raw score. Semantic similarity between words emerged as the strongest predictor of word adjacency for all fluency tasks, including the letter fluency tasks. Semantic similarity mediated the effect of cognitive impairment on word adjacency only for three fluency tasks employing a biological cue. Orthographic similarity was predictive of word adjacency for the A and S tasks, while phonemic similarity was predictive only for the S task and one semantic task (vehicles). The ROI analysis revealed different patterns of correlations among the various fluency tasks, with the most common associations in the right lower temporal and bilateral dorsal frontal regions. Following correction with gray matter volumes from the opposite hemisphere, significant associations persisted for animals, vehicles, and a composite

  16. Japanese version of the Montreal Cognitive Assessment cut-off score to clarify improvement of mild cognitive impairment after exercise training in community-dwelling older adults.

    Science.gov (United States)

    Nara, Marina; Sugie, Masamitsu; Takahashi, Tetsuya; Koyama, Teruyuki; Sengoku, Renpei; Fujiwara, Yoshinori; Obuchi, Shuichi; Harada, Kazumasa; Kyo, Shunei; Ito, Hideki

    2018-02-02

    Physical exercise improves cognitive function in people with mild cognitive impairment (MCI). However, information about whether the degree of MCI before exercise training affects improvement in cognitive function is lacking. Therefore, we aimed to investigate the cut-off value in a MCI screening tool that predicts reversal to normal cognitive function after exercise training in older adults with MCI. Participants included 112 Japanese community-dwelling older adult outpatients (37 men, 75 women; mean age 76.3 years). We administered the Japanese version of the Montreal Cognitive Assessment (MoCA-J) before and after exercise training. MCI was defined as a MoCA-J score cognitive function. The MoCA-J cut-off score to predict cognitive function potentially reversible to normal was 23, with receiver operating characteristic analysis showing an area under the curve of 0.80, sensitivity of 79.4% and specificity of 69.2%. Multiple logistic regression analysis to predict non-MCI after exercise training showed that MoCA-J score ≥23 (OR 6.9, P cognitive function that is potentially reversible to normal among community-dwelling Japanese older adults with MCI. Geriatr Gerontol Int 2018; ••: ••-••. © 2018 The Authors Geriatrics & Gerontology International published by John Wiley & Sons Australia, Ltd on behalf of Japan Geriatrics Society.

  17. "You've got a friend in me": can social networks mediate the relationship between mood and MCI?

    OpenAIRE

    Yates, Jennifer A.; Clare, Linda; Woods, Robert T.

    2017-01-01

    Background Social networks can change with age, for reasons that are adaptive or unwanted. Social engagement is beneficial to both mental health and cognition, and represents a potentially modifiable factor. Consequently this study explored this association and assessed whether the relationship between mild cognitive impairment (MCI) and mood problems was mediated by social networks. Methods This study includes an analysis of data from the Cognitive Function and Ageing Study Wales (CFAS Wales...

  18. Assessment of PET & ASL metabolism in the hippocampal subfields of MCI and AD using simultaneous PET-MR

    Energy Technology Data Exchange (ETDEWEB)

    Goubran, Maged; Douglas, David; Chao, Steven; Quon, Andrew; Tripathi, Pragya; Holley, Dawn; Vasanawala, Minal; Zaharchuk, Greg; Zeineh, Michael [Stanford University (United States)

    2015-05-18

    Alzheimer’s disease (AD) has been reported to show decreased metabolic activity in the hippocampus using FDG PET-MR. Histological data suggests that the hippocampal subfields are selectively affected in AD. Given the simultaneous imaging nature of integrated PET-MR scanners and the multimodal capabilities of PET-MR, our purpose here is to assess FDG activity, as well as ASL perfusion in the subfields of MCI and AD patients. 10 consecutive subjects were recruited for this study 3 MCI, 3 AD patients and 4 age-matched controls. The scanning was performed on a simultaneous 3T PET/MR scanner. To delineate the hippocampal subfields, automatic segmentation of hippocampal subfields (ASHS) was employed. Static FDG-PET series were reconstructed for analysis at 45-75 min for all subjects. All imaging sequences were automatically registered to the oblique coronal T2-weighted images (segmentation space). PET standardized uptake values (SUV) in the hippocampal subfields were normalized by the pons. FDG PET metabolism was reduced significantly in AD, as well as MCI patients as compared to controls, with the highest effect demonstrated in the CA3/DG and CA1/2 (p = 0.047, subfields. Patients (MCI and AD combined) had decreased metabolism as compared to controls in CA1/2 and significantly smaller volumes the Subiculum. When assessing CBF across groups, a significant decrease in CBF was found in the Subiculum. Our preliminary results demonstrate that PET-MRI may potentially be a sensitive biomarker and tool for early diagnosis of AD. They also confirm the importance of assessing metabolic and structural changes of neurodegenerative diseases at the subfield level.

  19. Sensitivities and detection limits of X-ray fluorescence analysis with a 10 mCi241Am source

    International Nuclear Information System (INIS)

    Wundt, K.; Janghorbani, M.; Starke, K.

    1976-01-01

    Seven trace elements ranging from chromium to barium were preconcentrated on Amberlite IR-120 cation exchange paper and determined in an energy dispersive X-ray fluorescence system using a 10 mCi 241 Am source. Sensitivities were experimentally determined and checked with theoretically calculated values. The detection limits are compared with elemental levels present in typical surface waters and those allowed in drinking water. Appropriate conclusions as to feasibility of such a system for environmental monitoring are drawn. (orig.) [de

  20. EMS Response to Mass Casualty Incidents: The Critical Importance of Automatic Statewide Mutual Aid and MCI Training

    Science.gov (United States)

    2008-09-01

    incidents, dam failure, earthquakes, fires and wild fires, thunderstorms, tsunamis, volcanoes , winter storms, heat, landslides , nuclear power plant...President Bush reorganized the federal government and created the U.S. Department of Homeland Security, which produced the National Strategy for...to produce the best outcome and ensure personnel safety. This discipline prevented units from treating the first victim they came upon and ensured

  1. Five-year follow-up of {sup 11}C-PIB uptake in Alzheimer's disease and MCI

    Energy Technology Data Exchange (ETDEWEB)

    Kemppainen, N.M.; Scheinin, N.M.; Koivunen, J.; Johansson, J.; Toivonen, J.T.; Naagren, K.; Rokka, J.; Rinne, J.O. [University of Turku, Turku PET Centre, P.O. Box 52, Turku (Finland); Karrasch, M. [Abo Akademi University, Department of Psychology and Logopedics, Turku (Finland); Parkkola, R. [Tampere University and Tampere University Hospital, Department of Radiology, Tampere (Finland)

    2014-02-15

    The aim of this study was to evaluate the longitudinal changes in [{sup 11}C]PIB uptake in mild cognitive impairment (MCI) and Alzheimer's disease (AD) over a long-term follow-up. Six AD patients, ten MCI patients and eight healthy subjects underwent a [{sup 11}C]PIB PET scan at baseline and at 2 and 5 years. The clinical status of the MCI patients was evaluated every 6 months. The MCI group showed a significant increase in [{sup 11}C]PIB uptake over time (p < 0.001), with a similar increase from baseline to 2 years (4.7 % per year) and from 2 to 5 years (5.0 % per year). Eight MCI patients (80 %) converted to AD, and two of these patients showed a normal [{sup 11}C]PIB scan at baseline but increased uptake later. There was an increase in [{sup 11}C]PIB uptake with time in the AD group (p = 0.02), but this did not significantly differ from the change in the control group. Our results revealed a significant increase in amyloid load even at the time of AD diagnosis in some of the MCI patients who converted. A positive [{sup 11}C]PIB scan at baseline in MCI patients strongly predicted future conversion to AD but a negative PIB scan in MCI patients did not exclude future conversion. The results suggest that there is wide individual variation in the brain amyloid load in MCI, and in the course of amyloid accumulation in relation to the clinical diagnosis of AD. (orig.)

  2. Citation analysis of The Korean Journal of Internal Medicine from KoMCI, Web of Science, and Scopus.

    Science.gov (United States)

    Huh, Sun

    2011-03-01

    The Korean Journal of Internal Medicine (KJIM) is the international journal published in English by the Korean Association of Internal Medicine. To understand the position of the journal in three different databases, the citation indicators were elucidated. From databases such as Korean Medical Citation Index (KoMCI), Web of Science, and Scopus, citation indicators such as the impact factor, SCImago journal rank (SJR), or Hirsch Index were calculated according to the year and the results were drawn. The KJIM 2010 impact factor increased to 0.623 in Web of Science. That of year 2009 in KoMCI was a 0.149. The 2009 SJR in Scopus was 0.073, with a ranking of 27/72 (37.5%) in the category of internal medicine and 414/1,618 (25.6%) in the category of medicine, miscellaneous. The Hirsch Index from KoMCI, Web of Science and Scopus were 5, 14, and 16, respectively. The KJIM is now cited more by international researchers than Korean researchers, indicating that the content of the journal is now valued at the international level.

  3. Mapping brain morphological and functional conversion patterns in amnestic MCI: a voxel-based MRI and FDG-PET study

    Energy Technology Data Exchange (ETDEWEB)

    Morbelli, Silvia [University of Genoa, Nuclear Medicine Unit, Department of Internal Medicine, Genoa (Italy); Piccardo, Arnoldo; Villavecchia, Giampiero [Galliera Hospital, Nuclear Medicine Unit, Department of Radiology, Genoa (Italy); Dessi, Barbara; Brugnolo, Andrea; Rodriguez, Guido; Nobili, Flavio [University of Genoa, Clinical Neurophysiology Unit, Department of Neurosciences, Ophthalmology and Genetics, Genoa (Italy); Piccini, Alessandra [Cell Biology Unit, National Cancer Research Institute, Genoa (Italy); Caroli, Anna [LENITEM - Laboratory of Epidemiology Neuroimaging and Telemedicine, Brescia (Italy); Mario Negri Institute, Medical Imaging Unit, Biomedical Engineering Department, Bergamo (Italy); Frisoni, Giovanni [LENITEM - Laboratory of Epidemiology Neuroimaging and Telemedicine, Brescia (Italy)

    2010-01-15

    To reveal the morphological and functional substrates of memory impairment and conversion to Alzheimer disease (AD) from the stage of amnestic mild cognitive impairment (aMCI). Brain MRI and FDG-PET were performed in 20 patients with aMCI and 12 controls at baseline. During a mean follow-up of about 2 years, 9 patients developed AD (converters), and 11 did not (nonconverters). All images were processed with SPM2. FDG-PET and segmented grey matter (GM) images were compared in: (1) converters versus controls, (2) nonconverters versus controls, and (3) converters versus nonconverters. As compared to controls, converters showed lower GM density in the left parahippocampal gyrus and both thalami, and hypometabolism in the precuneus, posterior cingulate and superior parietal lobule in the left hemisphere. Hypometabolism was found in nonconverters as compared to controls in the left precuneus and posterior cingulated gyrus. As compared to nonconverters, converters showed significant hypometabolism in the left middle and superior temporal gyri. The discordant topography between atrophy and hypometabolism reported in AD is already present at the aMCI stage. Posterior cingulate-precuneus hypometabolism seemed to be an early sign of memory deficit, whereas hypometabolism in the left temporal cortex marked the conversion to AD. (orig.)

  4. Self-administered Gerocognitive Examination (SAGE): a brief cognitive assessment Instrument for mild cognitive impairment (MCI) and early dementia.

    Science.gov (United States)

    Scharre, Douglas W; Chang, Shu-Ing; Murden, Robert A; Lamb, James; Beversdorf, David Q; Kataki, Maria; Nagaraja, Haikady N; Bornstein, Robert A

    2010-01-01

    To develop a self-administered cognitive assessment instrument to facilitate the screening of mild cognitive impairment (MCI) and early dementia and determine its association with gold standard clinical assessments including neuropsychologic evaluation. Adults aged above 59 years with sufficient vision and English literacy were recruited from geriatric and memory disorder clinics, educational talks, independent living facilities, senior centers, and memory screens. After Self-administered Gerocognitive Examination (SAGE) screening, subjects were randomly selected to complete a clinical evaluation, neurologic examination, neuropsychologic battery, functional assessment, and mini-mental state examination (MMSE). Subjects were identified as dementia, MCI, or normal based on standard clinical criteria and neuropsychologic testing. Two hundred fifty-four participants took the SAGE screen and 63 subjects completed the extensive evaluation (21 normal, 21 MCI, and 21 dementia subjects). Spearman rank correlation between SAGE and neuropsychologic battery was 0.84 (0.76 for MMSE). SAGE receiver operating characteristics on the basis of clinical diagnosis showed 95% specificity (90% for MMSE) and 79% sensitivity (71% for MMSE) in detecting those with cognitive impairment from normal subjects. This study suggests that SAGE is a reliable instrument for detecting cognitive impairment and compares favorably with the MMSE. The self-administered feature may promote cognitive testing by busy clinicians prompting earlier diagnosis and treatment.

  5. Mapping brain morphological and functional conversion patterns in amnestic MCI: a voxel-based MRI and FDG-PET study

    International Nuclear Information System (INIS)

    Morbelli, Silvia; Piccardo, Arnoldo; Villavecchia, Giampiero; Dessi, Barbara; Brugnolo, Andrea; Rodriguez, Guido; Nobili, Flavio; Piccini, Alessandra; Caroli, Anna; Frisoni, Giovanni

    2010-01-01

    To reveal the morphological and functional substrates of memory impairment and conversion to Alzheimer disease (AD) from the stage of amnestic mild cognitive impairment (aMCI). Brain MRI and FDG-PET were performed in 20 patients with aMCI and 12 controls at baseline. During a mean follow-up of about 2 years, 9 patients developed AD (converters), and 11 did not (nonconverters). All images were processed with SPM2. FDG-PET and segmented grey matter (GM) images were compared in: (1) converters versus controls, (2) nonconverters versus controls, and (3) converters versus nonconverters. As compared to controls, converters showed lower GM density in the left parahippocampal gyrus and both thalami, and hypometabolism in the precuneus, posterior cingulate and superior parietal lobule in the left hemisphere. Hypometabolism was found in nonconverters as compared to controls in the left precuneus and posterior cingulated gyrus. As compared to nonconverters, converters showed significant hypometabolism in the left middle and superior temporal gyri. The discordant topography between atrophy and hypometabolism reported in AD is already present at the aMCI stage. Posterior cingulate-precuneus hypometabolism seemed to be an early sign of memory deficit, whereas hypometabolism in the left temporal cortex marked the conversion to AD. (orig.)

  6. Evaluation of radioiodine therapy with fixed doses of 10 and 15 mCi in patients with Graves disease

    International Nuclear Information System (INIS)

    Canadas, Viviane; Vilar, Lucio; Moura, Eliane; Brito, Ana; Castellar, Enio

    2007-01-01

    The treatment options for the hyperthyroidism of Graves' disease are antithyroid drugs, surgery and radioiodine, none of which is considered ideal, as they do not act directly on the etiopathogenesis of the disease. Radioiodine has been increasingly used as the treatment of choice because it is a safe and definitive therapy whose administration is very easy. Some authors prefer to administer higher doses in order to deliberately induce hypothyroidism, while others recommend lower doses that result in a lower incidence of hypothyroidism and a greater incidence of euthyroidism. There is no consensus for the optimal regimen of fixed doses to be used and this is the main focus of the present study, where doses of 10 and 15 mCi of 131 I were compared. Among the 164 patients analyzed, 61 (37.2%) were submitted to 10 mCi and 103 (62.8%) to 15 mCi. In the longitudinal analysis it was observed that remission of the hyperthyroidism was statistically different in the sixth month (p 131 I brought about a similar remission of the hyperthyroidism after 12 months of treatment. Moreover, the remission rate of the hyperthyroidism had no association with age, sex or previous therapy with antithyroid drugs. (author)

  7. Dense image correspondences for computer vision

    CERN Document Server

    Liu, Ce

    2016-01-01

    This book describes the fundamental building-block of many new computer vision systems: dense and robust correspondence estimation. Dense correspondence estimation techniques are now successfully being used to solve a wide range of computer vision problems, very different from the traditional applications such techniques were originally developed to solve. This book introduces the techniques used for establishing correspondences between challenging image pairs, the novel features used to make these techniques robust, and the many problems dense correspondences are now being used to solve. The book provides information to anyone attempting to utilize dense correspondences in order to solve new or existing computer vision problems. The editors describe how to solve many computer vision problems by using dense correspondence estimation. Finally, it surveys resources, code, and data necessary for expediting the development of effective correspondence-based computer vision systems.   ·         Provides i...

  8. Performing prototype distortion tasks requires no contribution from the explicit memory systems: evidence from amnesic MCI patients in a new experimental paradigm.

    Science.gov (United States)

    Zannino, Gian Daniele; Perri, Roberta; Zabberoni, Silvia; Caltagirone, Carlo; Marra, Camillo; Carlesimo, Giovanni A

    2012-10-01

    Evidence shows that amnesic patients are able to categorize new exemplars drawn from the same prototype as in previously encountered items. It is still unclear, however, whether this ability is due to a spared implicit learning system or residual explicit memory and/or working memory resources. In this study, we used a new paradigm devised expressly to rule out any possible contribution of episodic and working memory in performing a prototype distortion task. We enrolled patients with amnesic MCI and Normal Controls. Our paradigm consisted of a study phase and a test phase; two-thirds of the participants performed the study phase and all participants performed the test phase. In the study phase, participants had to judge how pleasant morphed faces, drawn from a single prototype, seemed to them. Half of the participants were shown faces drawn from the A-prototype and half from the B-prototype. A- and B-faces were opposite in a morphing space with a neutral human face at the center. In the test phase, participants had to judge the regularity of faces they had never seen before. Three different types of faces were shown in the test phase, that is, A-, B-, or neutral-faces. We expected that implicit learning of the category boundaries would lead to a category-specific increase in perceived regularity. The results confirmed our predictions. In fact, trained subjects (compared with subjects who did not undergo the study phase) assigned higher regularity scores to new faces drawn from the same prototype as the faces seen during training, and they gave lower regularity scores to new faces drawn from the opposite prototype. This effect was super imposable across subjects' groups. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. The value of whole-brain CT perfusion imaging and CT angiography using a 320-slice CT scanner in the diagnosis of MCI and AD patients

    International Nuclear Information System (INIS)

    Zhang, Bo; Gu, Guo-jun; Jiang, Hong; Guo, Yi; Shen, Xing; Li, Bo; Zhang, Wei

    2017-01-01

    To validate the value of whole-brain computed tomography perfusion (CTP) and CT angiography (CTA) in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Whole-brain CTP and four-dimensional CT angiography (4D-CTA) images were acquired in 30 MCI, 35 mild AD patients, 35 moderate AD patients, 30 severe AD patients and 50 normal controls (NC). Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and correlation between CTP and 4D-CTA were analysed. Elevated CBF in the left frontal and temporal cortex was found in MCI compared with the NC group. However, TTP was increased in the left hippocampus in mild AD patients compared with NC. In moderate and severe AD patients, hypoperfusion was found in multiple brain areas compared with NC. Finally, we found that the extent of arterial stenosis was negatively correlated with CBF in partial cerebral cortex and hippocampus, and positively correlated with TTP in these areas of AD and MCI patients. Our findings suggest that whole-brain CTP and 4D-CTA could serve as a diagnostic modality in distinguishing MCI and AD, and predicting conversion from MCI based on TTP of left hippocampus. (orig.)

  10. The value of whole-brain CT perfusion imaging and CT angiography using a 320-slice CT scanner in the diagnosis of MCI and AD patients

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Bo; Gu, Guo-jun; Jiang, Hong; Guo, Yi [Medical School of Tongji University, Department of Medical Imaging, Tongji Hospital, Shanghai (China); Shen, Xing [Traditional Chinese Hospital, Department of Radiology, Kun Shan, Jiangsu Province (China); Li, Bo; Zhang, Wei [Medical School of Jiaotong University, Department of Medical Imaging, Renji Hospital, Shanghai (China)

    2017-11-15

    To validate the value of whole-brain computed tomography perfusion (CTP) and CT angiography (CTA) in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Whole-brain CTP and four-dimensional CT angiography (4D-CTA) images were acquired in 30 MCI, 35 mild AD patients, 35 moderate AD patients, 30 severe AD patients and 50 normal controls (NC). Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and correlation between CTP and 4D-CTA were analysed. Elevated CBF in the left frontal and temporal cortex was found in MCI compared with the NC group. However, TTP was increased in the left hippocampus in mild AD patients compared with NC. In moderate and severe AD patients, hypoperfusion was found in multiple brain areas compared with NC. Finally, we found that the extent of arterial stenosis was negatively correlated with CBF in partial cerebral cortex and hippocampus, and positively correlated with TTP in these areas of AD and MCI patients. Our findings suggest that whole-brain CTP and 4D-CTA could serve as a diagnostic modality in distinguishing MCI and AD, and predicting conversion from MCI based on TTP of left hippocampus. (orig.)

  11. Correspondence analysis theory, practice and new strategies

    CERN Document Server

    Beh, Eric J

    2014-01-01

    A comprehensive overview of the internationalisation of correspondence analysis Correspondence Analysis: Theory, Practice and New Strategies examines the key issues of correspondence analysis, and discusses the new advances that have been made over the last 20 years. The main focus of this book is to provide a comprehensive discussion of some of the key technical and practical aspects of correspondence analysis, and to demonstrate how they may be put to use.  Particular attention is given to the history and mathematical links of the developments made. These links include not just those majo

  12. Comparisons of physical and chemical sputtering in high density divertor plasmas with the Monte Carlo Impurity (MCI) transport model

    International Nuclear Information System (INIS)

    Evans, T.E.; Loh, Y.S.; West, W.P.; Finkenthal, D.F.

    1997-11-01

    The MCI transport model was used to compare chemical and physical sputtering for a DIII-D divertor plasma near detachment. With physical sputtering alone the integrated carbon influx was 8.4 x 10 19 neutral/s while physical plus chemical sputtering produced an integrated carbon influx of 1.7 x 10 21 neutrals/s. The average carbon concentration in the computational volume increased from 0.012% with only physical sputtering to 0.182% with both chemical and physical sputtering. This increase in the carbon inventory produced more radiated power which is in better agreement with experimental measurements

  13. 28 CFR 540.14 - General correspondence.

    Science.gov (United States)

    2010-07-01

    ... would facilitate criminal activity; (ii) If the inmate is on a restricted correspondence list; (iii) If... if it might facilitate criminal activity. Correspondence which may be rejected by a Warden includes... which may lead to the use of physical violence or group disruption; (3) Information of escape plots, of...

  14. Prefrontal activation may predict working-memory training gain in normal aging and mild cognitive impairment

    NARCIS (Netherlands)

    Vermeij, A.; Kessels, R.P.C.; Heskamp, L.; Simons, E.M.F.; Dautzenberg, P.LJ.; Claassen, J.A.H.R.

    2017-01-01

    Cognitive training has been shown to result in improved behavioral performance in normal aging and mild cognitive impairment (MCI), yet little is known about the neural correlates of cognitive plasticity, or about individual differences in responsiveness to cognitive training. In this study, 21

  15. Computer-Based Training Programs for Older People with Mild Cognitive Impairment and/or Dementia

    Directory of Open Access Journals (Sweden)

    Blanka Klimova

    2017-05-01

    Full Text Available Currently, due to the demographic trends, the number of aging population groups is dramatically rising, especially in developed countries. This trend causes serious economic and social issues, but also an increase of aging disorders such as mild cognitive impairment (MCI or dementia in older population groups. MCI and dementia are connected with deterioration of cognitive functions. The aim of this mini review article is therefore to explore whether computer-based training programs might be an effective intervention tool for older people with MCI and/or dementia or not. The methods include a literature search in the world’s acknowledged databases: Web of Science, Scopus, Science Direct, MEDLINE and Springer, and consequently, evaluation of the findings of the relevant studies. The findings from the selected studies are quite neutral with respect to the efficacy of the computer assisted intervention programs on the improvement of basic cognitive functions. On the one hand, they suggest that the computer-based training interventions might generate some positive effects on patients with MCI and/or dementia, such as the improvement of learning and short-term memory, as well as behavioral symptoms. On the other hand, these training interventions seem to be short-term, with small sample sizes and their efficacy was proved only in the half of the detected studies. Therefore more longitudinal randomized controlled trials (RCTs are needed to prove the efficacy of the computer-based training programs among older individuals with MCI and/or dementia.

  16. N-acetylaspartate, choline and myoinositol concentration changes in MR spectroscopy (1H MRS) of hippocampal formation in patients with mild cognitive impairment (MCI) - preliminary study

    International Nuclear Information System (INIS)

    Pawlowska, A.; Cwikla, J.; Walecki, J.; Gabryelewicz, T.; Barcikowska, M.

    2004-01-01

    Cognitive and memory impairment are very common problems in elderly patients. Mild cognitive impairment (MCI) is known as a transitional clinical state between normal ('successful') aging and dementia. In some cases MCI may be a precursor to Alzheimer's disease (AD). Early neuronal loss and metabolic changes have been documented in previous studies in AD patients in some 'strategic ' regions of the brain, mainly in hippocampal formation. Our goal was to determine whether there are statistically significant changes in hippocampal N-acetylaspartate, choline and myoinositol levels obtained by single-voxel spectroscopy in MCI patients and normal aging and to evaluate its clinical diagnostic utility. 30 patients with MCI and 15 cognitively normal elderly subjects underwent proton MR spectroscopy at 1.5 T system. MR spectra were obtained from anterior and posterior part of hippocampal formation bilaterally, using the point-resolved spectroscopy sequence. Metabolite ratios of NAA/H 2 O, Cho/H 2 O and mI/H 2 O were calculated from the peak height measurements. Relative to the control group, patients with MCI demonstrated elevated mI/H 2 O and Cho/H 2 O ratios in both hippocampal formations. The most significant increase was observed in mI/H 2 O ratio in anterior part of left hippocampus and in Cho/H 2 O ratio in posterior part of right hippocampus, in MCI patients vs.cognitively normal elderly. There were no significant differences between mean NAA/H 2 O ratios measured in hippocampal formation in both groups. Proton MRS may be used as valuable additional tool in the evaluation of regional metabolic changes in patients with MCI. Increase of mI and Cho levels in hippocampal formation may be an early sign of cognitive impairment in elderly subjects that can be measured using MRS. (author)

  17. ADMultiImg: a novel missing modality transfer learning based CAD system for diagnosis of MCI due to AD using incomplete multi-modality imaging data

    Science.gov (United States)

    Liu, Xiaonan; Chen, Kewei; Wu, Teresa; Weidman, David; Lure, Fleming; Li, Jing

    2018-02-01

    Alzheimer's Disease (AD) is the most common cause of dementia and currently has no cure. Treatments targeting early stages of AD such as Mild Cognitive Impairment (MCI) may be most effective to deaccelerate AD, thus attracting increasing attention. However, MCI has substantial heterogeneity in that it can be caused by various underlying conditions, not only AD. To detect MCI due to AD, NIA-AA published updated consensus criteria in 2011, in which the use of multi-modality images was highlighted as one of the most promising methods. It is of great interest to develop a CAD system based on automatic, quantitative analysis of multi-modality images and machine learning algorithms to help physicians more adequately diagnose MCI due to AD. The challenge, however, is that multi-modality images are not universally available for many patients due to cost, access, safety, and lack of consent. We developed a novel Missing Modality Transfer Learning (MMTL) algorithm capable of utilizing whatever imaging modalities are available for an MCI patient to diagnose the patient's likelihood of MCI due to AD. Furthermore, we integrated MMTL with radiomics steps including image processing, feature extraction, and feature screening, and a post-processing for uncertainty quantification (UQ), and developed a CAD system called "ADMultiImg" to assist clinical diagnosis of MCI due to AD using multi-modality images together with patient demographic and genetic information. Tested on ADNI date, our system can generate a diagnosis with high accuracy even for patients with only partially available image modalities (AUC=0.94), and therefore may have broad clinical utility.

  18. Coherence and correspondence in engineering design

    Directory of Open Access Journals (Sweden)

    Konstantinos V. Katsikopoulos

    2009-03-01

    Full Text Available I show how the coherence/correspondence distinction can inform the conversation about decision methods for engineering design. Some engineers argue for the application of multi-attribute utility theory while others argue for what they call heuristics. To clarify the differences among methods, I first ask whether each method aims at achieving coherence or correspondence. By analyzing statements in the design literature, I argue that utility theory aims at achieving coherence and heuristics aim at achieving correspondence. Second, I ask if achieving coherence always implies achieving correspondence. It is important to provide an answer because while in design the objective is correspondence, it is difficult to assess it, and coherence that is easier to assess is used as a surrogate. I argue that coherence does not always imply correspondence in design and that this is also the case in problems studied in judgment and decision-making research. Uncovering the conditions under which coherence implies, or does not imply, correspondence is a topic where engineering design and judgment and decision-making research might connect.

  19. Effects of bilingualism on the age of onset and progression of MCI and AD: evidence from executive function tests.

    Science.gov (United States)

    Bialystok, Ellen; Craik, Fergus I M; Binns, Malcolm A; Ossher, Lynn; Freedman, Morris

    2014-03-01

    Previous articles have reported that bilingualism is associated with a substantial delay in the onset of both Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). The present study reports results from 74 MCI patients and 75 AD patients; approximately half of the patients in each group were bilingual. All patients were interviewed to obtain details of their language use, onset of their condition, and lifestyle habits. Patients performed three executive function (EF) tests from the D-KEFS battery (Trails, Color-Word Interference, Verbal Fluency) on 3 occasions over a period of approximately 1 year. Results replicated the finding that bilingual patients are several years older than comparable monolinguals at both age of symptom onset and date of first clinic visit. This result could not be attributed to language group differences in such lifestyle variables as diet, smoking, alcohol consumption, physical activity, or social activity. On the first testing occasion, performance on the EF tasks was generally comparable between the language groups, contesting arguments that bilinguals wait longer before attending the clinic. Finally, EF performance tended to decline over the 3 sessions, but no differences were found between monolinguals and bilinguals in the rate of decline. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  20. Microcystin Biosynthesis and mcyA Expression in Geographically Distinct Microcystis Strains under Different Nitrogen, Phosphorus, and Boron Regimes

    Directory of Open Access Journals (Sweden)

    Ankita Srivastava

    2016-01-01

    Full Text Available Roles of nutrients and other environmental variables in development of cyanobacterial bloom and its toxicity are complex and not well understood. We have monitored the photoautotrophic growth, total microcystin concentration, and microcystins synthetase gene (mcyA expression in lab-grown strains of Microcystis NIES 843 (reference strain, KW (Wangsong Reservoir, South Korea, and Durgakund (Varanasi, India under different nutrient regimes (nitrogen, phosphorus, and boron. Higher level of nitrogen and boron resulted in increased growth (avg. 5 and 6.5 Chl a mg/L, resp., total microcystin concentrations (avg. 1.185 and 7.153 mg/L, resp., and mcyA transcript but its expression was not directly correlated with total microcystin concentrations in the target strains. Interestingly, Durgakund strain had much lower microcystin content and lacked microcystin-YR variant over NIES 843 and KW. It is inferred that microcystin concentration and its variants are strain specific. We have also examined the heterotrophic bacteria associated with cyanobacterial bloom in Durgakund Pond and Wangsong Reservoir which were found to be enriched in Alpha-, Beta-, and Gammaproteobacteria and that could influence the bloom dynamics.

  1. The AdS/CFT correspondence

    International Nuclear Information System (INIS)

    Hubeny, Veronika E

    2015-01-01

    We give a brief review of the AdS/CFT correspondence, which posits the equivalence between a certain gravitational theory and a lower-dimensional non-gravitational one. This remarkable duality, formulated in 1997, has sparked a vigorous research program that has gained in breadth over the years, with applications to many aspects of theoretical (and even experimental) physics, not least to general relativity and quantum gravity. To put the AdS/CFT correspondence into historical context, we start by reviewing the relevant aspects of string theory (of which no prior knowledge is assumed). We then develop the statement of the correspondence, and explain how the two sides of the duality map into each other. Finally, we discuss the implications and applications of the correspondence, and indicate some of the current trends in this subject. The presentation attempts to convey the main concepts in a simple and self-contained manner, relegating supplementary remarks to footnotes. (paper)

  2. 45 CFR 170.405 - Correspondence.

    Science.gov (United States)

    2010-10-01

    ... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Temporary Certification Program for HIT § 170.405 Correspondence. (a...

  3. Effective diameters and corresponding states of fluids

    Science.gov (United States)

    Del Río, Fernando

    Effective hard-sphere diameters of fluids with purely repulsive interactions are derived from a generalized corresponding-states principle of Leland, Rowlinson and coworkers. Various alternative definitions are discussed and related. Virial expansions of the effective diameters and their corresponding volumes are obtained and compared with results of perturbation theory. Applications are made to inverse-power potentials, the repulsive part of the Lennard-Jones potential and hard spherocylinders and dumbells.

  4. 18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

    Science.gov (United States)

    Martínez, Gabriel; Vernooij, Robin Wm; Fuentes Padilla, Paulina; Zamora, Javier; Bonfill Cosp, Xavier; Flicker, Leon

    2017-11-22

    18 F-florbetapir uptake by brain tissue measured by positron emission tomography (PET) is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using amyloid biomarkers tests like 18 F-florbetapir. These tests, added to the MCI core clinical criteria, might increase the diagnostic test accuracy (DTA) of a testing strategy. However, the DTA of 18 F-florbetapir to predict the progression from MCI to Alzheimer's disease dementia (ADD) or other dementias has not yet been systematically evaluated. To determine the DTA of the 18 F-florbetapir PET scan for detecting people with MCI at time of performing the test who will clinically progress to ADD, other forms of dementia (non-ADD), or any form of dementia at follow-up. This review is current to May 2017. We searched MEDLINE (OvidSP), Embase (OvidSP), PsycINFO (OvidSP), BIOSIS Citation Index (Thomson Reuters Web of Science), Web of Science Core Collection, including the Science Citation Index (Thomson Reuters Web of Science) and the Conference Proceedings Citation Index (Thomson Reuters Web of Science), LILACS (BIREME), CINAHL (EBSCOhost), ClinicalTrials.gov (https://clinicaltrials.gov), and the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) (http://www.who.int/ictrp/search/en/). We also searched ALOIS, the Cochrane Dementia & Cognitive Improvement Group's specialised register of dementia studies (http://www.medicine.ox.ac.uk/alois/). We checked the reference lists of any relevant studies and systematic reviews, and

  5. Tensor network state correspondence and holography

    Science.gov (United States)

    Singh, Sukhwinder

    2018-01-01

    In recent years, tensor network states have emerged as a very useful conceptual and simulation framework to study quantum many-body systems at low energies. In this paper, we describe a particular way in which any given tensor network can be viewed as a representation of two different quantum many-body states. The two quantum many-body states are said to correspond to each other by means of the tensor network. We apply this "tensor network state correspondence"—a correspondence between quantum many-body states mediated by tensor networks as we describe—to the multi-scale entanglement renormalization ansatz (MERA) representation of ground states of one dimensional (1D) quantum many-body systems. Since the MERA is a 2D hyperbolic tensor network (the extra dimension is identified as the length scale of the 1D system), the two quantum many-body states obtained from the MERA, via tensor network state correspondence, are seen to live in the bulk and on the boundary of a discrete hyperbolic geometry. The bulk state so obtained from a MERA exhibits interesting features, some of which caricature known features of the holographic correspondence of String theory. We show how (i) the bulk state admits a description in terms of "holographic screens", (ii) the conformal field theory data associated with a critical ground state can be obtained from the corresponding bulk state, in particular, how pointlike boundary operators are identified with extended bulk operators. (iii) We also present numerical results to illustrate that bulk states, dual to ground states of several critical spin chains, have exponentially decaying correlations, and that the bulk correlation length generally decreases with increase in central charge for these spin chains.

  6. On Painlevé/gauge theory correspondence

    Science.gov (United States)

    Bonelli, Giulio; Lisovyy, Oleg; Maruyoshi, Kazunobu; Sciarappa, Antonio; Tanzini, Alessandro

    2017-12-01

    We elucidate the relation between Painlevé equations and four-dimensional rank one N = 2 theories by identifying the connection associated with Painlevé isomonodromic problems with the oper limit of the flat connection of the Hitchin system associated with gauge theories and by studying the corresponding renormalization group flow. Based on this correspondence, we provide long-distance expansions at various canonical rays for all Painlevé τ -functions in terms of magnetic and dyonic Nekrasov partition functions for N = 2 SQCD and Argyres-Douglas theories at self-dual Omega background ɛ _1 + ɛ _2 = 0 or equivalently in terms of c=1 irregular conformal blocks.

  7. Integration and relative value of biomarkers for prediction of MCI to AD progression: Spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers

    Directory of Open Access Journals (Sweden)

    Xiao Da

    2014-01-01

    Full Text Available This study evaluates the individual, as well as relative and joint value of indices obtained from magnetic resonance imaging (MRI patterns of brain atrophy (quantified by the SPARE-AD index, cerebrospinal fluid (CSF biomarkers, APOE genotype, and cognitive performance (ADAS-Cog in progression from mild cognitive impairment (MCI to Alzheimer's disease (AD within a variable follow-up period up to 6 years, using data from the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI-1. SPARE-AD was first established as a highly sensitive and specific MRI-marker of AD vs. cognitively normal (CN subjects (AUC = 0.98. Baseline predictive values of all aforementioned indices were then compared using survival analysis on 381 MCI subjects. SPARE-AD and ADAS-Cog were found to have similar predictive value, and their combination was significantly better than their individual performance. APOE genotype did not significantly improve prediction, although the combination of SPARE-AD, ADAS-Cog and APOE ε4 provided the highest hazard ratio estimates of 17.8 (last vs. first quartile. In a subset of 192 MCI patients who also had CSF biomarkers, the addition of Aβ1–42, t-tau, and p-tau181p to the previous model did not improve predictive value significantly over SPARE-AD and ADAS-Cog combined. Importantly, in amyloid-negative patients with MCI, SPARE-AD had high predictive power of clinical progression. Our findings suggest that SPARE-AD and ADAS-Cog in combination offer the highest predictive power of conversion from MCI to AD, which is improved, albeit not significantly, by APOE genotype. The finding that SPARE-AD in amyloid-negative MCI patients was predictive of clinical progression is not expected under the amyloid hypothesis and merits further investigation.

  8. Selective potentiation of noradrenaline in the guinea-pig vas deferens by 2-(4-methylaminobutoxy) diphenylmethane hydrochloride (MCI-2016), a new psychotropic drug.

    OpenAIRE

    Ohizumi, Y.; Takahashi, M.; Tobe, A.

    1982-01-01

    In the isolated vas deferens of the guinea-pig, the effects of 2-(4-methylaminobutoxy) diphenylmethane hydrochloride (MCI-2016), a new psychotropic drug, on the contractile response to various agonists or transmural electrical stimulation and on the release of noradrenaline (NA) from the tissue were examined and compared with cocaine. MCI-2016 (3 X 10(-6)M) and cocaine (3 X 10(-5)M) produced a leftward shift (15 and 20 times, respectively) of the dose-response curves for the contractile effec...

  9. Correspondence passed between Einstein and Schroedinger

    International Nuclear Information System (INIS)

    Balibar, F.

    1992-01-01

    The main points of the 26 year long correspondence between Einstein and Schroedinger are reviewed: from the de Broglie thesis and the Bose-Einstein statistics to the Schroedinger equation (1925-1926); from the EPR paradox to the cat parable (1935); a complete collaboration on unitary theories

  10. Thermodynamic Properties from Corresponding States Theory

    DEFF Research Database (Denmark)

    Mollerup, Jørgen

    1980-01-01

    A corresponding states approach has been applied to the two-constant equations of state by Wilson, Soave, Peng—Robinson, Hamam et al., Lu et al., Simonet—Behar, and Chaudron et al. in order to obtain the equivalent shape-factor correlations. The correlations derived are compared with the Leach...

  11. 77 FR 4998 - List of Correspondence

    Science.gov (United States)

    2012-02-01

    ... DEPARTMENT OF EDUCATION List of Correspondence AGENCY: Office of Special Education and... [cir] Letter dated September 26, 2011, to Commonwealth of Virginia Department of Education Special... permissible for a student's individualized education program (IEP) to include a postsecondary goal or goals...

  12. Using Correspondence Analysis in Multiple Case Studies

    NARCIS (Netherlands)

    Kienstra, Natascha; van der Heijden, Peter G.M.

    2015-01-01

    In qualitative research of multiple case studies, Miles and Huberman proposed to summarize the separate cases in a so-called meta-matrix that consists of cases by variables. Yin discusses cross-case synthesis to study this matrix. We propose correspondence analysis (CA) as a useful tool to study

  13. Using correspondence analysis in multiple case studies

    NARCIS (Netherlands)

    Kienstra, N.H.H.; van der Heijden, P.G.M.

    2015-01-01

    In qualitative research of multiple case studies, Miles and Huberman proposed to summarize the separate cases in a so-called meta-matrix that consists of cases by variables. Yin discusses cross-case synthesis to study this matrix. We propose correspondence analysis (CA) as a useful tool to study

  14. 34 CFR 686.25 - Correspondence study.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Correspondence study. 686.25 Section 686.25 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION TEACHER EDUCATION ASSISTANCE FOR COLLEGE AND HIGHER EDUCATION (TEACH) GRANT PROGRAM...

  15. AdS/CFT correspondence and supersymmetry

    International Nuclear Information System (INIS)

    Dobrev, V.K.

    2002-05-01

    We use the group-theoretic interpretation of the AdS/CFT correspondence which we proposed earlier in order to lift intertwining operators acting between boundary conformal representations to intertwining operators acting between bulk conformal representations. Further, we present the classification of the positive energy (lowest weight) unitary irreducible representations of the D=6 superconformal algebras osp(8*/2N). (author)

  16. 12 CFR 7.5007 - Correspondent services.

    Science.gov (United States)

    2010-01-01

    ... Electronic Activities § 7.5007 Correspondent services. It is part of the business of banking for a national... of software that performs data processing functions; (d) The development, operation, management, and marketing of products and processing services for transactions conducted at electronic terminal devices; (e...

  17. Fundamentals of Solar Heating. Correspondence Course.

    Science.gov (United States)

    Sheet Metal and Air Conditioning Contractors National Association, Vienna, VA.

    This course is designed for the use of employees of the air conditioning industry, and offers supervised correspondence instruction about solar technology. The following aspects of applied solar technology are covered: solar heating and cooling, solar radiation, solar collectors, heat storage control devices and specialty items, sizing solar…

  18. 456 Hours to Train the Reserve Component: Analysis of the Impact of Increased Annual Training Requirements on 4th Assault Amphibian Battalion

    Science.gov (United States)

    2016-12-01

    blended learning format” (p. 92). Online training can be used in the following ways: a sole source of learning , supplemental traditional, follow-up to... Learned MCI Marine Corps Institute MCO Marine Corps Order MCR Marine Corps Reserve MCTIMS Marine Corps Training Information Management System MCTL...Reserve SMCR Selected Marine Corps Reserve SNCO Staff Noncommissioned Officer SUL Small Unit Leader TAM Technology Acceptance Model TEEP Training

  19. Introduction to AdS/CFT correspondence

    CERN Document Server

    Nastase, Horatiu

    2015-01-01

    Providing a pedagogical introduction to the rapidly developing field of AdS/CFT correspondence, this is one of the first texts to provide an accessible introduction to all the necessary concepts needed to engage with the methods, tools and applications of AdS/CFT. Without assuming anything beyond an introductory course in quantum field theory, it begins by guiding the reader through the basic concepts of field theory and gauge theory, general relativity, supersymmetry, supergravity, string theory and conformal field theory, before moving on to give a clear and rigorous account of AdS/CFT correspondence. The final section discusses the more specialised applications, including QCD, quark-gluon plasma and condensed matter. This book is self-contained and learner-focused, featuring numerous exercises and examples. It is essential reading for both students and researchers across the fields of particle, nuclear and condensed matter physics.

  20. Correspondence Theory and Phonological Blending in French

    Directory of Open Access Journals (Sweden)

    Lee Scott

    2014-07-01

    Full Text Available Though less productive than rival word-formation processes like compounding and affixation, blending is still a rich source of neologisms in French. Despite this productivity, however, blends are often seen by scholars as unpredictable, uninteresting, or both. This analysis picks up where recent studies of blending have left off, using Correspondence Theory and a bundle of segmental constraints to deal with this phenomenon as it pertains to French. More specifically, it shows that blending is the result of a single output standing in correspondence with two or more other outputs, and that we do not need to refer to prosodic information, which is crucial in accounts of blending in languages with lexical stress like English, to account for the process in French. The analysis also differs from previous studies in that it locates blending exclusively within the phonology, leaving its morphological and semantic characteristics to be handled by other processes in the grammar.

  1. Mitogenomes of polar bodies and corresponding oocytes.

    Directory of Open Access Journals (Sweden)

    Luca Gianaroli

    Full Text Available The objective of the present study was to develop an approach that could assess the chromosomal status and the mitochondrial DNA (mtDNA content of oocytes and their corresponding polar bodies (PBs with the goal of obtaining a comparative picture of the segregation process both for nuclear and mtDNA. After Whole Genome Amplification (WGA, sequencing of the whole mitochondrial genome was attempted to analyze the segregation of mutant and wild-type mtDNA during human meiosis. Three triads, composed of oocyte and corresponding PBs, were analyzed and their chromosome status was successfully assessed. The complete mitochondrial genome (mitogenome was almost entirely sequenced in the oocytes (95.99% compared to 98.43% in blood, while the percentage of sequences obtained in the corresponding PB1 and PB2 was lower (69.70% and 69.04% respectively. The comparison with the mtDNA sequence in blood revealed no changes in the D-loop region for any of the cells of each triad. In the coding region of blood mtDNA and oocyte mtDNA sequences showed full correspondence, whereas all PBs had at least one change with respect to the blood-oocyte pairs. In all, 9 changes were found, either in PB1 or PB2: 4 in MT-ND5, 2 in MT-RNR2, and 1 each in MT-ATP8, MT-ND4, MT-CYTB. The full concordance between oocyte and blood in the 3 triads, and the relegation of changes to PBs, revealed the unexpected coexistence of different variants, giving a refined estimation of mitochondrial heteroplasmy. Should these findings be confirmed by additional data, an active mechanism could be postulated in the oocyte to preserve a condition of 'normality'.

  2. Mahnaz MOHAMADZADEH (Correspond author) Jabraeal FARZANEH

    OpenAIRE

    MOHAMADZADEH, Mahnaz; FARZANEH, Jabraeal; MOUSAVi, Mina; MAGHABL, Rouhallah

    2015-01-01

    Higher education in Iran is confronting with several challenges; Some of them are increasing demand for education and insufficiency of current programs to meet the growing needs, emerging information age and the necessity of achieving information literacy, speed up in knowledge production and the necessity of development of a lifelong and continuous training system, necessity of considering to user orientation and extending educational justice. It is assumes that a high performance e-learning...

  3. Crowdsourcing for reference correspondence generation in endoscopic images.

    Science.gov (United States)

    Maier-Hein, Lena; Mersmann, Sven; Kondermann, Daniel; Stock, Christian; Kenngott, Hannes Gotz; Sanchez, Alexandro; Wagner, Martin; Preukschas, Anas; Wekerle, Anna-Laura; Helfert, Stefanie; Bodenstedt, Sebastian; Speidel, Stefanie

    2014-01-01

    Computer-assisted minimally-invasive surgery (MIS) is often based on algorithms that require establishing correspondences between endoscopic images. However, reference annotations frequently required to train or validate a method are extremely difficult to obtain because they are typically made by a medical expert with very limited resources, and publicly available data sets are still far too small to capture the wide range of anatomical/scene variance. Crowdsourcing is a new trend that is based on outsourcing cognitive tasks to many anonymous untrained individuals from an online community. To our knowledge, this paper is the first to investigate the concept of crowdsourcing in the context of endoscopic video image annotation for computer-assisted MIS. According to our study on publicly available in vivo data with manual reference annotations, anonymous non-experts obtain a median annotation error of 2 px (n = 10,000). By applying cluster analysis to multiple annotations per correspondence, this error can be reduced to about 1 px, which is comparable to that obtained by medical experts (n = 500). We conclude that crowdsourcing is a viable method for generating high quality reference correspondences in endoscopic video images.

  4. Generation of human iPSC line GRX-MCiPS4F-A2 from adult peripheral blood mononuclear cells (PBMCs with Spanish genetic background

    Directory of Open Access Journals (Sweden)

    Sonia Cabrera

    2015-09-01

    Full Text Available We have generated iPSCs from peripheral blood mononuclear cells (PBMCs of a healthy man using heat sensitive and non-integrative Sendai virus containing Sox2, Oct3/4, c-Myc and Klf4. Human GRX-MCiPS4F-A2 cell line was established and characterized through this study.

  5. Correspondence normalized ghost imaging on compressive sensing

    International Nuclear Information System (INIS)

    Zhao Sheng-Mei; Zhuang Peng

    2014-01-01

    Ghost imaging (GI) offers great potential with respect to conventional imaging techniques. It is an open problem in GI systems that a long acquisition time is be required for reconstructing images with good visibility and signal-to-noise ratios (SNRs). In this paper, we propose a new scheme to get good performance with a shorter construction time. We call it correspondence normalized ghost imaging based on compressive sensing (CCNGI). In the scheme, we enhance the signal-to-noise performance by normalizing the reference beam intensity to eliminate the noise caused by laser power fluctuations, and reduce the reconstruction time by using both compressive sensing (CS) and time-correspondence imaging (CI) techniques. It is shown that the qualities of the images have been improved and the reconstruction time has been reduced using CCNGI scheme. For the two-grayscale ''double-slit'' image, the mean square error (MSE) by GI and the normalized GI (NGI) schemes with the measurement number of 5000 are 0.237 and 0.164, respectively, and that is 0.021 by CCNGI scheme with 2500 measurements. For the eight-grayscale ''lena'' object, the peak signal-to-noise rates (PSNRs) are 10.506 and 13.098, respectively using GI and NGI schemes while the value turns to 16.198 using CCNGI scheme. The results also show that a high-fidelity GI reconstruction has been achieved using only 44% of the number of measurements corresponding to the Nyquist limit for the two-grayscale “double-slit'' object. The qualities of the reconstructed images using CCNGI are almost the same as those from GI via sparsity constraints (GISC) with a shorter reconstruction time. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  6. Super-Liouville — double Liouville correspondence

    Science.gov (United States)

    Hadasz, Leszek; Jaskólski, Zbigniew

    2014-05-01

    The AGT motivated relation between the tensor product of the = 1 super-Liouville field theory with the imaginary free fermion (SL) and a certain projected tensor product of the real and the imaginary Liouville field theories (LL) is analyzed. Using conformal field theory techniques we give a complete proof of the equivalence in the NS sector. It is shown that the SL-LL correspondence is based on the equivalence of chiral objects including suitably chosen chiral structure constants of all the three Liouville theories involved.

  7. Super-Liouville — double Liouville correspondence

    International Nuclear Information System (INIS)

    Hadasz, Leszek; Jaskólski, Zbigniew

    2014-01-01

    The AGT motivated relation between the tensor product of the N=1 super-Liouville field theory with the imaginary free fermion (SL) and a certain projected tensor product of the real and the imaginary Liouville field theories (LL) is analyzed. Using conformal field theory techniques we give a complete proof of the equivalence in the NS sector. It is shown that the SL-LL correspondence is based on the equivalence of chiral objects including suitably chosen chiral structure constants of all the three Liouville theories involved.

  8. Super-Liouville — double Liouville correspondence

    Energy Technology Data Exchange (ETDEWEB)

    Hadasz, Leszek [M. Smoluchowski Institute of Physics, Jagiellonian University,W. Reymonta 4, 30-059 Kraków (Poland); Jaskólski, Zbigniew [Institute of Theoretical Physics, University of Wrocław,pl. M. Borna 1, 95-204 Wrocław (Poland)

    2014-05-27

    The AGT motivated relation between the tensor product of the N=1 super-Liouville field theory with the imaginary free fermion (SL) and a certain projected tensor product of the real and the imaginary Liouville field theories (LL) is analyzed. Using conformal field theory techniques we give a complete proof of the equivalence in the NS sector. It is shown that the SL-LL correspondence is based on the equivalence of chiral objects including suitably chosen chiral structure constants of all the three Liouville theories involved.

  9. Instability and degeneracy in the BMN correspondence

    International Nuclear Information System (INIS)

    Freedman, Daniel Z.; Guersoy, Umut

    2003-01-01

    Non-degenerate perturbation theory, which was used to calculate the scale dimension of operators on the gauge theory side of the correspondence, breaks down when effects of triple trace operators are included. We interpret this as an instability of excited single-string states in the dual string theory for decay into the continuum of degenerate 3-string states. We apply time-dependent perturbation theory to calculate the decay widths from gauge theory. These widths are new gauge theory data which can be compared with future calculations in light cone string field theory. (author)

  10. Ordinal-Measure Based Shape Correspondence

    Directory of Open Access Journals (Sweden)

    Faouzi Alaya Cheikh

    2002-04-01

    Full Text Available We present a novel approach to shape similarity estimation based on distance transformation and ordinal correlation. The proposed method operates in three steps: object alignment, contour to multilevel image transformation, and similarity evaluation. This approach is suitable for use in shape classification, content-based image retrieval and performance evaluation of segmentation algorithms. The two latter applications are addressed in this papers. Simulation results show that in both applications our proposed measure performs quite well in quantifying shape similarity. The scores obtained using this technique reflect well the correspondence between object contours as humans perceive it.

  11. Quantum classical correspondence in nonrelativistic electrodynamics

    International Nuclear Information System (INIS)

    Ritchie, B.; Weatherford, C.A.

    1999-01-01

    A form of classical electrodynamic field exists which gives exact agreement with the operator field of quantum electrodynamics (QED) for the Lamb shift of a harmonically bound point electron. Here it is pointed out that this form of classical theory, with its physically acceptable interpretation, is the result of an unconventional resolution of a mathematically ambiguous term in classical field theory. Finally, a quantum classical correspondence principle is shown to exist in the sense that the classical field and expectation value of the QED operator field are identical, if retardation is neglected in the latter

  12. Functional Correspondence between Evaluators and Abstract Machines

    DEFF Research Database (Denmark)

    Ager, Mads Stig; Biernacki, Dariusz; Danvy, Olivier

    2003-01-01

    We bridge the gap between functional evaluators and abstract machines for the λ-calculus, using closure conversion, transformation into continuation-passing style, and defunctionalization.We illustrate this approach by deriving Krivine's abstract machine from an ordinary call-by-name evaluator...... and by deriving an ordinary call-by-value evaluator from Felleisen et al.'s CEK machine. The first derivation is strikingly simpler than what can be found in the literature. The second one is new. Together, they show that Krivine's abstract machine and the CEK machine correspond to the call-by-name and call...

  13. Evaluation of treatment with 15 mCi of 131I to patients bearing toxic diffuse goiter (graves disease)

    International Nuclear Information System (INIS)

    Filho, J.A.; Silva, J.M. Ferreira da; Santoro, C.

    2008-01-01

    Full text: The multiple interferences of the physical and social environment on the people, represented especially for the lack of iodine, the basic chemical element for good functioning of the thyroid, in interior or raised regions; in situations of nutritional deficiency or excess of that chemical element absorbed through foods and or drugs; by stress and inadequate feeding to which they are submitted, when facing assumed social responsibilities; for the rural exodus in search of new chances in the great cities; and especially, the women, for the consequences of the continuous use of contraceptives; for greater sensitivity to the humoral and tumoral answers etc., if it becomes the greater target of the thyroid disease called Toxic Diffuse Goiter or Graves disease, as is verified in this report, the existence of about 4 women for each 1 man. However, the implemented sanitary actions for the treatment that such complex diseases, demand, are not satisfactory. The applied doses, on average, are not satisfying the necessities, according to the study carried out with 180 patients (38 males and 142 females), with an average age of (43.6 ± 12.6) years, varying from 15 to 70 years; an average thyroid mass of (37.4 ± 19.5) g, varying from 19.0 to 89.3 g; an average 24-hour uptake of 131 I of (53.6 ± 20.3) %, varying from 20.5 88.1 %; that they had been submitted to in average radiotherapeutic activity of (15.0 ± 1.4) mCi, varying from 12 to 20 mCi; where the output was (41.1 ± 15.6) % and the rate of desistance reached (52.4 ± 15.3) %. A retrospective study on the radiotherapeutic efficiency, covering dozens of treatments and thousands of patients from dozens of countries, in physical, clinical and biokinetic situations of iodine uptake by he thyroid, on average, similar to ours showed that the most efficient average dose, compared with our averages of dosimetric parameters, was about 30.2-34.5 mCi, that is, 2.0-2.3 times bigger than that the applied here. The data

  14. TCMB’nin Para Politikası Duruşunun Alternatif Açıklaması: Parasal Durum Endeksi (MCI (Alternative Explanations for the Monetary Stance of CBRT: Monetary Condition Index (MCI

    Directory of Open Access Journals (Sweden)

    Bora SÜSLÜ

    2012-01-01

    Full Text Available Knowledge of economic agent’s expectations enables the policy authorities to evaluate responsiveness of economic and political decisions. Hence, all central banks in the World including the Central Bank of Republic of Turkey (CBRT want to know public expectations and re-use this knowledge to influence expectations of people especially in implementing interest rate as an instrument. However, considering the stability of economy, central banks try to take into account real variables which are more flexible and effective as policy tools. Moreover, real variables are directly related to welfare of the society.The main aim of this study is to investigate whether the monetary stance of CBRT that bases on policy rules takes into account aggregate demand that impacts growth and price level during past decade. The study employs ARDL approach using time series data obtained from CBRT. The results indicate that CBRT was heavily relied on Monetary Condition Index (MCI over the past decade contrary to its official discourse.

  15. To an effective local Langlands correspondence

    CERN Document Server

    Bushnell, Colin J

    2014-01-01

    Let F be a non-Archimedean local field. Let \\mathcal{W}_{F} be the Weil group of F and \\mathcal{P}_{F} the wild inertia subgroup of \\mathcal{W}_{F}. Let \\widehat {\\mathcal{W}}_{F} be the set of equivalence classes of irreducible smooth representations of \\mathcal{W}_{F}. Let \\mathcal{A}^{0}_{n}(F) denote the set of equivalence classes of irreducible cuspidal representations of \\mathrm{GL}_{n}(F) and set \\widehat {\\mathrm{GL}}_{F} = \\bigcup _{n\\ge 1} \\mathcal{A}^{0}_{n}(F). If \\sigma \\in \\widehat {\\mathcal{W}}_{F}, let ^{L}{\\sigma }\\in \\widehat {\\mathrm{GL}}_{F} be the cuspidal representation matched with \\sigma by the Langlands Correspondence. If \\sigma is totally wildly ramified, in that its restriction to \\mathcal{P}_{F} is irreducible, the authors treat ^{L}{\\sigma} as known. From that starting point, the authors construct an explicit bijection \\mathbb{N}:\\widehat {\\mathcal{W}}_{F} \\to \\widehat {\\mathrm{GL}}_{F}, sending \\sigma to ^{N}{\\sigma}. The authors compare this "naïve correspondence" with the L...

  16. Effect of 30 mCi radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone

    Energy Technology Data Exchange (ETDEWEB)

    Paz-Filho, G.J.; Mesa-Junior, C.O.; Boguszewski, C.L.; Carvalho, G.A.; Graf, H. [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Hospital de Clinicas. Servico de Endocrinologia e Metabologia; Olandoski, M. [Pontificia Univ. Catolica do Parana, Curitiba, PR (Brazil). Nucleo de Bioestatistica; Woellner, L.C. [Centro de Medicina Nuclear, Curitiba, PR (Brazil); Goedert, C.A. [Centro de Tomografia Computadorizada, Curitiba, PR (Brazil)

    2007-12-15

    Recombinant human thyroid-stimulating hormone (rhTSH) enhances {sup 131}I uptake, permitting a decrease in radiation for the treatment of multinodular goiter (MNG). Our objective was to evaluate the safety and efficacy of a single 0.1-mg dose of rhTSH, followed by 30 mCi {sup 131}I, in patients with MNG. Seventeen patients (15 females, 59.0 {+-} 13.1 years), who had never been submitted to {sup 131}I therapy, received a single 0.1-mg injection of rhTSH followed by 30 mCi {sup 131}I on the next day. Mean basal thyroid volume measured by computed tomography was 106.1 {+-} 64.4 mL. {sup 131}I 24-h uptake, TSH, free-T4, T3, thyroglobulin, anti-thyroid antibodies, and thyroid volume were evaluated at regular intervals of 12 months. Mean {sup 131}I 24-h uptake increased from 18.1 {+-} 9.7 to 49.6 {+-} 13.4% (P < 0.001), a median 2.6-fold increase (1.2 to 9.2). Peak hormonal levels were 10.86 {+-} 5.44 mU/L for TSH (a median 15.5-fold increase), 1.80 {+-} 0.48 ng/dL for free-T4, 204.61 {+-} 58.37 ng/dL for T3, and a median of 557.0 ng/mL for thyroglobulin. The adverse effects observed were hyperthyroidism (17.6%), painful thyroiditis (29.4%) and hypothyroidism (52.9%). Thyroid volume was reduced by 34.3 {+-} 14.3% after 6 months (P < 0.001) and by 46.0 {+-} 14.6% after 1 year (P < 0.001). Treatment of MNG with a single 0.1-mg dose of rhTSH, followed by a fixed amount of radioactivity of {sup 131}I, leads to an efficacious decrease in thyroid volume for the majority of the patients, with a moderate incidence of non-serious and readily treatable adverse effects. (author)

  17. Effect of 30 mCi radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone

    Directory of Open Access Journals (Sweden)

    G.J. Paz-Filho

    2007-12-01

    Full Text Available Recombinant human thyroid-stimulating hormone (rhTSH enhances 131I uptake, permitting a decrease in radiation for the treatment of multinodular goiter (MNG. Our objective was to evaluate the safety and efficacy of a single 0.1-mg dose of rhTSH, followed by 30 mCi 131I, in patients with MNG. Seventeen patients (15 females, 59.0 ± 13.1 years, who had never been submitted to 131I therapy, received a single 0.1-mg injection of rhTSH followed by 30 mCi 131I on the next day. Mean basal thyroid volume measured by computed tomography was 106.1 ± 64.4 mL. 131I 24-h uptake, TSH, free-T4, T3, thyroglobulin, anti-thyroid antibodies, and thyroid volume were evaluated at regular intervals of 12 months. Mean 131I 24-h uptake increased from 18.1 ± 9.7 to 49.6 ± 13.4% (P < 0.001, a median 2.6-fold increase (1.2 to 9.2. Peak hormonal levels were 10.86 ± 5.44 mU/L for TSH (a median 15.5-fold increase, 1.80 ± 0.48 ng/dL for free-T4, 204.61 ± 58.37 ng/dL for T3, and a median of 557.0 ng/mL for thyroglobulin. The adverse effects observed were hyperthyroidism (17.6%, painful thyroiditis (29.4% and hypothyroidism (52.9%. Thyroid volume was reduced by 34.3 ± 14.3% after 6 months (P < 0.001 and by 46.0 ± 14.6% after 1 year (P < 0.001. Treatment of MNG with a single 0.1-mg dose of rhTSH, followed by a fixed amount of radioactivity of 131I, leads to an efficacious decrease in thyroid volume for the majority of the patients, with a moderate incidence of non-serious and readily treatable adverse effects.

  18. Mild cognitive impairment (MCI) - the novel trend of targeting Alzheimer's disease in its early stages - methodological considerations.

    Science.gov (United States)

    Pater, C

    2011-11-01

    While much uncertainty exists in the estimates of the global burden of Alzheimer's disease and about the potential impact of various interventions, there is a widespread acceptance of the fact that the steady increase in the incidence and prevalence of the condition worldwide is becoming a massive public health problem as well as a huge economic burden for all healthcare systems and societies. These heavy demands are further compounded by the poor quality of life of the affected individuals, of their families and of their caregivers. The epidemic proportion of Alzheimer's disease has triggered relentless attempts for development of treatment approaches during the past two decades by a multitude of pharmaceuticals and biotech companies. Commercial development of the acetylcholinesterase inhibitors has, until recently, virtually dominated the field and, although efficacy has been demonstrated for five different products, the longterm clinical results suggested that alternate approaches were warranted. Disease modifying strategies targeting the β- amyloid plaques (e.g., decreasing β-amyloid formation through β- and γ-secretase inhibition, diminishing β-amyloid aggregation through anti-aggregants or enhancement of β-amyloid clearance through active/passive immunization), targeting the neurofibrillary tangles through inhibition of tau protein hyperphosphorilation or, more recently, by increasing mitochondrial permeability, all these potential treatment modalities are facing major methodological challenges during the conduct of a myriad of clinical trials meant to bring the novel therapies to the market. Failure of more than 400 products tested in more than 800 clinical trials to date, with many of these failures occurring in late stage development (phase III) have triggered a paradigm shift toward targeting of the early stages of cognitive deficiencies (mild cognitive impairment- MCI) and a refinement of the investigative methodologies. The great heterogeneity of

  19. The dS/dS correspondence

    International Nuclear Information System (INIS)

    Alishahiha, M.; Karch, A.; Silverstein, E.; Tong, D.

    2004-07-01

    We present a holographic duality for the de Sitter static patch which consolidates basic features of its geometry and the behavior of gravity and brane probes, valid on timescales short compared to the decay or Poincare recurrence times. Namely de Sitter spacetime dS d (R) in d dimensions with curvature radius R is holographically dual to two conformal field theories on dS d-l (R), cut off at an energy scale 1/R where they couple to each other and to d-1 dimensional gravity. As part of our analysis, we study brane probes in de Sitter and thermal Anti de Sitter spaces, and interpret the terms in the corresponding DBI action via strongly coupled thermal field theory. This provides a dual field theoretic interpretation of the fact that probes take forever to reach a horizon in general relativity. (author)

  20. The dS/dS Correspondence

    International Nuclear Information System (INIS)

    Alishahiha, Mohsen; Karch, Andreas; Silverstein, Eva; Tong, David

    2004-01-01

    We present a holographic duality for the de Sitter static patch which consolidates basic features of its geometry and the behavior of gravity and brane probes, valid on timescales short compared to the decay or Poincare recurrence times. Namely de Sitter spacetime dSd(R) in d dimensions with curvature radius R is holographically dual to two conformal field theories on dSd-1(R), cut off at an energy scale 1/R where they couple to each other and to d - 1 dimensional gravity. As part of our analysis, we study brane probes in de Sitter and thermal Anti de Sitter spaces, and interpret the terms in the corresponding DBI action via strongly coupled thermal field theory. This provides a dual field theoretic interpretation of the fact that probes take forever to reach a horizon in general relativity

  1. Refined 3d-3d correspondence

    Energy Technology Data Exchange (ETDEWEB)

    Alday, Luis F.; Genolini, Pietro Benetti; Bullimore, Mathew; Loon, Mark van [Mathematical Institute, University of Oxford, Andrew Wiles Building,Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG (United Kingdom)

    2017-04-28

    We explore aspects of the correspondence between Seifert 3-manifolds and 3d N=2 supersymmetric theories with a distinguished abelian flavour symmetry. We give a prescription for computing the squashed three-sphere partition functions of such 3d N=2 theories constructed from boundary conditions and interfaces in a 4d N=2{sup ∗} theory, mirroring the construction of Seifert manifold invariants via Dehn surgery. This is extended to include links in the Seifert manifold by the insertion of supersymmetric Wilson-’t Hooft loops in the 4d N=2{sup ∗} theory. In the presence of a mass parameter for the distinguished flavour symmetry, we recover aspects of refined Chern-Simons theory with complex gauge group, and in particular construct an analytic continuation of the S-matrix of refined Chern-Simons theory.

  2. Physical properties corresponding to vortical flow geometry

    Energy Technology Data Exchange (ETDEWEB)

    Nakayama, K, E-mail: nakayama@aitech.ac.jp [Department of Mechanical Engineering, Aichi Institute of Technology, Toyota, Aichi 470-0392 (Japan)

    2014-10-01

    We examine a vortical flow geometry specified by the velocity gradient tensor ∇v, and derive properties representing the symmetry (axisymmetry or skewness) of the vortical flow in the swirl plane and a property specifying inflowing (outflowing) motion in all directions around the point. We focus on the radial and azimuthal velocities in a plane nonparallel to the eigenvector corresponding to the real eigenvalue of ∇v and show that these components are expressed as specific quadratic forms. The real and imaginary parts of the complex eigenvalues of ∇v represent averages of these eigenvalues of the quadratic forms, and are inadequate to specify the detailed flow geometry uniquely. The new properties complement specifying the precise flow geometry of the vortical flow.

  3. Correspondence principle for black holes and strings

    International Nuclear Information System (INIS)

    Horowitz, G.T.; Polchinski, J.

    1997-01-01

    For most black holes in string theory, the Schwarzschild radius in string units decreases as the string coupling is reduced. We formulate a correspondence principle, which states that (i) when the size of the horizon drops below the size of a string, the typical black hole state becomes a typical state of strings and D-branes with the same charges, and (ii) the mass does not change abruptly during the transition. This provides a statistical interpretation of black hole entropy. This approach does not yield the numerical coefficient, but gives the correct dependence on mass and charge in a wide range of cases, including neutral black holes. copyright 1997 The American Physical Society

  4. A Role of the Parasympathetic Nervous System in Cognitive Training.

    Science.gov (United States)

    Lin, Feng; Heffner, Kathi L; Ren, Ping; Tadin, Duje

    2017-01-01

    Vision-based speed of processing (VSOP) training can result in broad cognitive improvements in older adults with amnestic mild cognitive impairment (aMCI). What remains unknown, however, is what neurophysiological mechanisms account for the observed training effect. Much of the work in this area has focused on the central nervous system, neglecting the fact that the peripheral system can contributes to changes of the central nervous system and vice versa. We examined the prospective relationship between an adaptive parasympathetic nervous system response to cognitive stimuli and VSOP training-induced plasticity. Twenty-one participants with aMCI (10 for VSOP training, and 11 for mental leisure activities (MLA) control) were enrolled. We assessed high-frequency heart rate variability (HF-HRV) during training sessions, and striatum-related neural networks and cognition at baseline and post-training. Compared to MLA, the VSOP group showed a significant U-shaped pattern of HF-HRV response during training, as well as decreases in connectivity strength between bilateral striatal and prefrontal regions. These two effects were associated with training-induced improvements in both the trained (attention and processing speed) and transferred (working memory) cognitive domains. This work provides novel support for interactions between the central and the peripheral nervous systems in relation to cognitive training, and motivates further studies to elucidate the causality of the observed link. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  5. Benefits of Music Training in Mandarin-Speaking Pediatric Cochlear Implant Users

    Science.gov (United States)

    Fu, Qian-Jie; Galvin, John J., III; Wang, Xiaosong; Wu, Jiunn-Liang

    2015-01-01

    Purpose: The aims of this study were to assess young (5- to 10-year-old) Mandarin-speaking cochlear implant (CI) users' musical pitch perception and to assess the benefits of computer-based home training on performance. Method: Melodic contour identification (MCI) was used to assess musical pitch perception in 14 Mandarin-speaking pediatric CI…

  6. Positive Effects of Computer-Based Cognitive Training in Adults with Mild Cognitive Impairment

    Science.gov (United States)

    Herrera, C.; Chambon, C.; Michel, B. F.; Paban, V.; Alescio-Lautier, B.

    2012-01-01

    Considering the high risk for individuals with amnestic Mild Cognitive Impairment (A-MCI) to progress towards Alzheimer's disease (AD), we investigated the efficacy of a non-pharmacological intervention, that is, cognitive training that could reduce cognitive difficulties and delay the cognitive decline. For this, we evaluated the efficacy of a…

  7. Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy.

    Science.gov (United States)

    Barban, Francesco; Annicchiarico, Roberta; Pantelopoulos, Stelios; Federici, Alessia; Perri, Roberta; Fadda, Lucia; Carlesimo, Giovanni Augusto; Ricci, Claudia; Giuli, Simone; Scalici, Francesco; Turchetta, Chiara Stella; Adriano, Fulvia; Lombardi, Maria Giovanna; Zaccarelli, Chiara; Cirillo, Giulio; Passuti, Simone; Mattarelli, Paolo; Lymperopoulou, Olga; Sakka, Paraskevi; Ntanasi, Eva; Moliner, Reyes; Garcia-Palacios, Azucena; Caltagirone, Carlo

    2016-04-01

    The aim of this paper was to assess the efficacy of process-based cognitive training (pb-CT) combined with reminiscence therapy (RT) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and in healthy elderly (HE) subjects. This multicenter, randomized, controlled trial involved 348 participants with mAD, MCI, and HE from four European countries. Participants were randomly assigned to two arms of a crossover design: those in arm A underwent 3 months of computerized pb-CT for memory and executive functions combined with RT and 3 months of rest; those in arm B underwent the reverse. The primary outcome was the effect of the training on memory and executive functions performance. The secondary outcome was the effect of the training on functional abilities in mAD assessed with the instrumental activities of daily living. We found a significant effect of the training for memory in all three groups on delayed recall of the Rey Auditory Verbal Learning Test and for executive functions in HE on the phonological fluency test. MCI and HE participants maintained these effects at follow-up. MCI and mAD participants also showed a significant effect of the training on the Mini-mental state examination scale. Participants with mAD showed more stable instrumental activities of daily living during the training versus the rest period. Our results corroborate the positive effect of pb-CT and its maintenance primarily on memory in HE and MCI participants that did not seem to be potentiated by RT. Moreover, our results are very promising for the mAD participants. Copyright © 2015 John Wiley & Sons, Ltd.

  8. Neck and whole-body scanning with 5-mCi dose of (123)I as diagnostic tracer in patients with well-differentiated thyroid cancer.

    Science.gov (United States)

    Gulzar, Z; Jana, S; Young, I; Bukberg, P; Yen, V; Naddaf, S; Abdel-Dayem, H M

    2001-01-01

    To determine whether a 5-mCi dose of 123I can be used as an effective radiotracer for assessing the presence of remnant thyroid tissue and for searching for metastatic lesions in patients with well-differentiated thyroid cancer as well as to attempt to ascertain whether a scan performed only at 4 hours is sufficient for accurate diagnosis and might replace the conventional protocol of scanning at both 4 hours and 24 hours. We prospectively studied 27 patients who had undergone near-total thyroidectomy and had a documented diagnosis of well-differentiated thyroid carcinoma. Patients underwent scanning after receiving a 5-mCi dose of 123I, at a time when they had discontinued thyroid replacement therapy and had a thyrotropin level in excess of 30 mIU/mL. Whole-body images at 4 hours and 24 hours were obtained and were compared with posttherapy scans obtained 5 to 7 days after administration of 131I. Scans were interpreted by two board-certified nuclear medicine physicians. Of the 27 patients, 2 (7.4%) showed discordance between the 123I scan performed at 24 hours and the posttherapy 131I scan. When 4-hour images after administration of 123I were compared with the posttherapy 131I scans, a discordance rate of 14.8% (4 of 27 patients) was noted. In addition, two of these four patients showed lesions on the 24-hour images that were not seen on the 4-hour images (one with new lung metastatic involvement and the other with a local recurrence in the lower neck area). The prognosis and treatment of these two patients were substantially changed by the result of the 24-hour images. On comparison of scans obtained after administration of a 5-mCi dose of 123I with those obtained after 131I therapy, we conclude that 5 mCi of 123I produces images that have excellent quality and resolution and also compare favorably with those obtained after 131I therapy. Furthermore, a decrease in the dose of 123I from 10 mCi to 5 mCi lowered the cost of the study without compromising the

  9. A Novel Study Paradigm for Long-term Prevention Trials in Alzheimer Disease: The Placebo Group Simulation Approach (PGSA): Application to MCI data from the NACC database.

    Science.gov (United States)

    Berres, M; Kukull, W A; Miserez, A R; Monsch, A U; Monsell, S E; Spiegel, R

    2014-01-01

    The PGSA (Placebo Group Simulation Approach) aims at avoiding problems of sample representativeness and ethical issues typical of placebo-controlled secondary prevention trials with MCI patients. The PGSA uses mathematical modeling to forecast the distribution of quantified outcomes of MCI patient groups based on their own baseline data established at the outset of clinical trials. These forecasted distributions are then compared with the distribution of actual outcomes observed on candidate treatments, thus substituting for a concomitant placebo group. Here we investigate whether a PGSA algorithm that was developed from the MCI population of ADNI 1*, can reliably simulate the distribution of composite neuropsychological outcomes from a larger, independently selected MCI subject sample. Data available from the National Alzheimer's Coordinating Center (NACC) were used. We included 1523 patients with single or multiple domain amnestic mild cognitive impairment (aMCI) and at least two follow-ups after baseline. In order to strengthen the analysis and to verify whether there was a drift over time in the neuropsychological outcomes, the NACC subject sample was split into 3 subsamples of similar size. The previously described PGSA algorithm for the trajectory of a composite neuropsychological test battery (NTB) score was adapted to the test battery used in NACC. Nine demographic, clinical, biological and neuropsychological candidate predictors were included in a mixed model; this model and its error terms were used to simulate trajectories of the adapted NTB. The distributions of empirically observed and simulated data after 1, 2 and 3 years were very similar, with some over-estimation of decline in all 3 subgroups. The by far most important predictor of the NTB trajectories is the baseline NTB score. Other significant predictors are the MMSE baseline score and the interactions of time with ApoE4 and FAQ (functional abilities). These are essentially the same predictors

  10. La correspondance comme genre éthique Correspondance as an Ethical Genre

    Directory of Open Access Journals (Sweden)

    Anna Jaubert

    2010-10-01

    Full Text Available Les caractéristiques d’un genre de discours découlent de la situation de communication dans laquelle il s’inscrit, et qu’il reflète. Pour une correspondance, et singulièrement pour une correspondance d’auteurs, cette situation est celle d’une interaction à la fois directe et biaisée qui engage l’ethos de l’épistolier. Nous analysons les idéaux qu’il produit sur un fond de valeurs partagées. Le champ d’investigation retenu est celui de certaines correspondances célèbres du 18e siècle, car la lettre est à cette époque une manifestation très accomplie de la sociabilité. De ce fait, elle a connu une dérive littérarisante, source d’un décalage pragmatique qui l’attire dans la mouvance d’un genre second, la correspondance littéraire, où l’implication éthique du discours devient sa détermination majeure.The characteristics of a genre of discourse depend upon its specific situation of communication - the genre being embedded in this situation and, at the same time, reflecting it. Concerning correspondences, especially between authors, this situation consists of an interaction both direct and indirect, involving the ethos of the letter writer. Our analysis focuses on the ideals it produces on a background of shared values. The field of inquiry is a choice of famous correspondences of the 18th century, since the letter was at that time an accomplished manifestation of sociability. As such, it adopted a literary form, which created a pragmatic gap and put it under the dependence of another genre, the fictional correspondence, in which ethic implications became its determining factor.

  11. The scientific correspondence of Arcangelo Scacchi

    Directory of Open Access Journals (Sweden)

    Rossella De Ceglie

    2009-06-01

    Full Text Available

    The scientist Arcangelo Scacchi (1810-1893, is today rarely mentioned in histories of Italian science in the

    nineteenth century. Even a brief consideration of his career, however, reveals that his work was of great importance to the scientific community of his age. For more than fifty years he was Professor of Mineralogy at the University of Naples and Curator of the Royal Mineralogical Museum, which under his guidance enjoyed a period of unprecedented success. The as yet unpublished Scacchi papers shed interesting light on the world of this Italian naturalist. His correspondence reveals much about Scacchi’s role in the scientific community both in Italy and abroad, and illustrate the extent to which he was involved in contemporary debates and research in the fields of geology, mineralogy, volcanology and crystallography.


  12. Matching Cost Filtering for Dense Stereo Correspondence

    Directory of Open Access Journals (Sweden)

    Yimin Lin

    2013-01-01

    Full Text Available Dense stereo correspondence enabling reconstruction of depth information in a scene is of great importance in the field of computer vision. Recently, some local solutions based on matching cost filtering with an edge-preserving filter have been proved to be capable of achieving more accuracy than global approaches. Unfortunately, the computational complexity of these algorithms is quadratically related to the window size used to aggregate the matching costs. The recent trend has been to pursue higher accuracy with greater efficiency in execution. Therefore, this paper proposes a new cost-aggregation module to compute the matching responses for all the image pixels at a set of sampling points generated by a hierarchical clustering algorithm. The complexity of this implementation is linear both in the number of image pixels and the number of clusters. Experimental results demonstrate that the proposed algorithm outperforms state-of-the-art local methods in terms of both accuracy and speed. Moreover, performance tests indicate that parameters such as the height of the hierarchical binary tree and the spatial and range standard deviations have a significant influence on time consumption and the accuracy of disparity maps.

  13. Prefrontal activation may predict working-memory training gain in normal aging and mild cognitive impairment.

    Science.gov (United States)

    Vermeij, Anouk; Kessels, Roy P C; Heskamp, Linda; Simons, Esther M F; Dautzenberg, Paul L J; Claassen, Jurgen A H R

    2017-02-01

    Cognitive training has been shown to result in improved behavioral performance in normal aging and mild cognitive impairment (MCI), yet little is known about the neural correlates of cognitive plasticity, or about individual differences in responsiveness to cognitive training. In this study, 21 healthy older adults and 14 patients with MCI received five weeks of adaptive computerized working-memory (WM) training. Before and after training, functional Near-Infrared Spectroscopy (fNIRS) was used to assess the hemodynamic response in left and right prefrontal cortex during performance of a verbal n-back task with varying levels of WM load. After training, healthy older adults demonstrated decreased prefrontal activation at high WM load, which may indicate increased processing efficiency. Although MCI patients showed improved behavioral performance at low WM load after training, no evidence was found for training-related changes in prefrontal activation. Whole-group analyses showed that a relatively strong hemodynamic response at low WM load was related to worse behavioral performance, while a relatively strong hemodynamic response at high WM load was related to higher training gain. Therefore, a 'youth-like' prefrontal activation pattern at older age may be associated with better behavioral outcome and cognitive plasticity.

  14. Destruction of post-surgery thyroid remnants by 19 mCi (703 MBq) of iodine 131

    International Nuclear Information System (INIS)

    Tassy, D.; Lonchampt, M.F.; Minebois, A.; Antigny, J.F.

    1997-01-01

    The adjuvant treatment by iodine 131 in good prognostic forms of differentiated thyroid cancers (DTC) makes not the object of a general consensus. There is no study demonstrating the benefit from such a treatment. Administration of an elevated iodine 131 activity and the constraint of a supplementary hospitalization are in these conditions questionable. In 6 patients, presenting the criteria of good prognostic and in post-operation, ambulatory conditions, administration of 19 mCi (703 MBc) of iodine 131 was done without previous administration of tracing dosage, followed after 72 hours by a whole-body scintigraphy, in the usual pause conditions. This administration was repeated 6 to 12 months later and followed by a new scintigraphic examination. The cervical fixation of iodine 131 was established qualitatively and quantitatively (as compared with a control zone). Five/six patients presented initially a cervical intense fixation with the star-like usual image and 1/6 patient a moderated fixation. Beginning with the second administration no cervical fixation was noted in 4/6 patients and a very low fixation in 2/6 patients. The concomitantly measured thyroglobulin, under simulation by TSH endogenous, was 131 I after quasi-total thyroidectomy in good-prognostic forms of DTC, without administration of previous tracing dosage to avoid possible phenomena of thyroid tissue blocking, allows probably, in overwhelming majority of cases, both a full or quasi-full destruction of the thyroid remnants and a severe reduction in the thyroglobulin rate measured in the conditions of pause of hormone-therapy

  15. Female patients dosimetry in brain exams with PET/CT scan for diagnosis of Mild Cognitive Impairment (MCI)

    International Nuclear Information System (INIS)

    Santana, P.C.; Mamede, M.; Carvalho, F.M.V.; Mourao, A.P.

    2013-01-01

    Dementia affects over 35 million people worldwide, with strong personal, social and financial impacts. Alzheimer's disease is the most common form of dementia, accounting for 60-70% of cases, affecting mostly females. Recent technological innovations, using methods of anatomical and functional neuroimaging, with particular emphasis on PET / CT (positron emission tomography with computed tomography associated), have shown excellent prospects for early diagnosis of Alzheimer's disease represented by Mild Cognitive Impairment (MCI). The use of PET / CT helps diagnosis, but the patients effective dose is higher and directly dependent on the radiopharmaceutical activity and the computed tomographic (CT) protocol used. The aim of this study was evaluated the organs absorbed doses and effective doses in 59 female patients undergoing the PET/CT diagnostic technique. For the measurements of radiation levels from the CT was used TLD100 (LiF:Mg, Ti) Rod detectors inserted in Alderson Randon ® anthropomorphic phantom, which simulates a female pattern, of 155 cm and weight 50 kg, subjected to the same clinical protocol of acquiring patients images. The effective dose resulting from the radiopharmaceutical injected activity was estimated by ICRP106 model using the weight of the patients undergoing to the procedure. The average effective dose due was (7.65 ± 2.22) mSv. The effective dose contribution to the brain and the thyroid due to CT were (2.21 ± 0.38) and (0.72 ± 0.14) mSv, respectively. The use of CT optimized protocols can assist in reducing the dose in this type of procedure. (author)

  16. FDG-PET and CSF biomarker accuracy in prediction of conversion to different dementias in a large multicentre MCI cohort.

    Science.gov (United States)

    Caminiti, Silvia Paola; Ballarini, Tommaso; Sala, Arianna; Cerami, Chiara; Presotto, Luca; Santangelo, Roberto; Fallanca, Federico; Vanoli, Emilia Giovanna; Gianolli, Luigi; Iannaccone, Sandro; Magnani, Giuseppe; Perani, Daniela

    2018-01-01

    In this multicentre study in clinical settings, we assessed the accuracy of optimized procedures for FDG-PET brain metabolism and CSF classifications in predicting or excluding the conversion to Alzheimer's disease (AD) dementia and non-AD dementias. We included 80 MCI subjects with neurological and neuropsychological assessments, FDG-PET scan and CSF measures at entry, all with clinical follow-up. FDG-PET data were analysed with a validated voxel-based SPM method. Resulting single-subject SPM maps were classified by five imaging experts according to the disease-specific patterns, as "typical-AD", "atypical-AD" (i.e. posterior cortical atrophy, asymmetric logopenic AD variant, frontal-AD variant), "non-AD" (i.e. behavioural variant FTD, corticobasal degeneration, semantic variant FTD; dementia with Lewy bodies) or "negative" patterns. To perform the statistical analyses, the individual patterns were grouped either as "AD dementia vs. non-AD dementia (all diseases)" or as "FTD vs. non-FTD (all diseases)". Aβ42, total and phosphorylated Tau CSF-levels were classified dichotomously, and using the Erlangen Score algorithm. Multivariate logistic models tested the prognostic accuracy of FDG-PET-SPM and CSF dichotomous classifications. Accuracy of Erlangen score and Erlangen Score aided by FDG-PET SPM classification was evaluated. The multivariate logistic model identified FDG-PET "AD" SPM classification (Expβ = 19.35, 95% C.I. 4.8-77.8, p CSF Aβ42 (Expβ = 6.5, 95% C.I. 1.64-25.43, p CSF biomarkers.

  17. Female patients dosimetry in brain exams with PET/CT scan for diagnosis of Mild Cognitive Impairment (MCI)

    Energy Technology Data Exchange (ETDEWEB)

    Santana, P.C.; Mamede, M.; Carvalho, F.M.V., E-mail: pridili@gmail.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil); Mourao, A.P., E-mail: apratabhz@gmail.com [Centro Federal de Educacao Tecnologica, Belo Horionte, MG (Brazil). Dept. de Engenharia Eletrica; Oliveira, P.M.C.; Silva, T.A. da, E-mail: pmco@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2013-07-01

    Dementia affects over 35 million people worldwide, with strong personal, social and financial impacts. Alzheimer's disease is the most common form of dementia, accounting for 60-70% of cases, affecting mostly females. Recent technological innovations, using methods of anatomical and functional neuroimaging, with particular emphasis on PET / CT (positron emission tomography with computed tomography associated), have shown excellent prospects for early diagnosis of Alzheimer's disease represented by Mild Cognitive Impairment (MCI). The use of PET / CT helps diagnosis, but the patients effective dose is higher and directly dependent on the radiopharmaceutical activity and the computed tomographic (CT) protocol used. The aim of this study was evaluated the organs absorbed doses and effective doses in 59 female patients undergoing the PET/CT diagnostic technique. For the measurements of radiation levels from the CT was used TLD100 (LiF:Mg, Ti) Rod detectors inserted in Alderson Randon ® anthropomorphic phantom, which simulates a female pattern, of 155 cm and weight 50 kg, subjected to the same clinical protocol of acquiring patients images. The effective dose resulting from the radiopharmaceutical injected activity was estimated by ICRP106 model using the weight of the patients undergoing to the procedure. The average effective dose due was (7.65 ± 2.22) mSv. The effective dose contribution to the brain and the thyroid due to CT were (2.21 ± 0.38) and (0.72 ± 0.14) mSv, respectively. The use of CT optimized protocols can assist in reducing the dose in this type of procedure. (author)

  18. Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects.

    Science.gov (United States)

    Hua, Xue; Leow, Alex D; Parikshak, Neelroop; Lee, Suh; Chiang, Ming-Chang; Toga, Arthur W; Jack, Clifford R; Weiner, Michael W; Thompson, Paul M

    2008-11-15

    In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy elderly controls, scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). Using inverse-consistent 3D non-linear elastic image registration, we warped 676 individual brain MRI volumes to a population mean geometric template. Jacobian determinant maps were created, revealing the 3D profile of local volumetric expansion and compression. We compared the anatomical distribution of atrophy in 165 AD patients (age: 75.6+/-7.6 years), 330 MCI subjects (74.8+/-7.5), and 181 controls (75.9+/-5.1). Brain atrophy in selected regions-of-interest was correlated with clinical measurements--the sum-of-boxes clinical dementia rating (CDR-SB), mini-mental state examination (MMSE), and the logical memory test scores - at voxel level followed by correction for multiple comparisons. Baseline temporal lobe atrophy correlated with current cognitive performance, future cognitive decline, and conversion from MCI to AD over the following year; it predicted future decline even in healthy subjects. Over half of the AD and MCI subjects carried the ApoE4 (apolipoprotein E4) gene, which increases risk for AD; they showed greater hippocampal and temporal lobe deficits than non-carriers. ApoE2 gene carriers--1/6 of the normal group--showed reduced ventricular expansion, suggesting a protective effect. As an automated image analysis technique, TBM reveals 3D correlations between neuroimaging markers, genes, and future clinical changes, and is highly efficient for large-scale MRI studies.

  19. Volume of interest-based [18F]fluorodeoxyglucose PET discriminates MCI converting to Alzheimer's disease from healthy controls. A European Alzheimer's Disease Consortium (EADC study

    Directory of Open Access Journals (Sweden)

    M. Pagani

    2015-01-01

    Full Text Available An emerging issue in neuroimaging is to assess the diagnostic reliability of PET and its application in clinical practice. We aimed at assessing the accuracy of brain FDG-PET in discriminating patients with MCI due to Alzheimer's disease and healthy controls. Sixty-two patients with amnestic MCI and 109 healthy subjects recruited in five centers of the European AD Consortium were enrolled. Group analysis was performed by SPM8 to confirm metabolic differences. Discriminant analyses were then carried out using the mean FDG uptake values normalized to the cerebellum computed in 45 anatomical volumes of interest (VOIs in each hemisphere (90 VOIs as defined in the Automated Anatomical Labeling (AAL Atlas and on 12 meta-VOIs, bilaterally, obtained merging VOIs with similar anatomo-functional characteristics. Further, asymmetry indexes were calculated for both datasets. Accuracy of discrimination by a Support Vector Machine (SVM and the AAL VOIs was tested against a validated method (PALZ. At the voxel level SMP8 showed a relative hypometabolism in the bilateral precuneus, and posterior cingulate, temporo-parietal and frontal cortices. Discriminant analysis classified subjects with an accuracy ranging between .91 and .83 as a function of data organization. The best values were obtained from a subset of 6 meta-VOIs plus 6 asymmetry values reaching an area under the ROC curve of .947, significantly larger than the one obtained by the PALZ score. High accuracy in discriminating MCI converters from healthy controls was reached by a non-linear classifier based on SVM applied on predefined anatomo-functional regions and inter-hemispheric asymmetries. Data pre-processing was automated and simplified by an in-house created Matlab-based script encouraging its routine clinical use. Further validation toward nonconverter MCI patients with adequately long follow-up is needed.

  20. Register Variation in Electronic Business Correspondence

    Directory of Open Access Journals (Sweden)

    Rosa Giménez Moreno

    2011-06-01

    Full Text Available Electronic correspondence is a highly dynamic genre within the business world in which Register Variation (RV is frequently used as a tool to improve communication but it often can lead to misunderstanding. In order to shed some light on this still unexplored area, the present study firstly offers a practical approach to classify and analyse RV within professional communication. After this, it reviews previous studies on email writing to apply their findings to this approach and, in the third part of the study, a corpus of recent business emails in English is analysed to examine how the key parameters of RV are currently used within this genre. The results will show that, not only the context, but also the roles and intentions of the senders influence an email’s register, often causing internal oscillations between different registers within the same text.La correspondencia electrónica es un género comunicativo de especial dinamismo dentro del mundo empresarial en el que la variación de registros se utiliza como herramienta para mejorar la interacción y las relaciones entre los interlocutores, pero que a menudo también genera confusión y malentendidos. Para aportar luz a esta área, el presente trabajo ofrece una aproximación práctica para la clasificación y el análisis de los registros lingüísticos dentro de la comunicación profesional. A continuación, revisa los estudios previos sobre este género con el fin de adaptar sus resultados a la teoría propuesta. Finalmente, se analiza un corpus de mensajes escritos en inglés para examinar el funcionamiento de los registros dentro de este género. Los resultados mostrarán que, no solo el contexto situacional, sino sobre todo los roles e intenciones de los emisores determinan el registro de un mensaje, provocando a menudo oscilación interna entre varios registros dentro del mismo texto.

  1. Medical Records and Correspondence Demand Respect

    Directory of Open Access Journals (Sweden)

    M Benamer

    2007-01-01

    Full Text Available To The Editor: I was amazed recently to see a patient from Libya who came to the UK for treatment based on the advice of his Libyan physicians. The patient carried with him no referral letter whatsoever. Not one physician familiar with his case bothered to write a few lines for the poor patient, although each of those doctors saw the patient at least twice and prescribed one or more treatment. The patient carried with him different medications that had been prescribed, and a few empty containers of other medicines he had used. I mention the above short tale to bring to light what I feel is a major ethical problem with the way medicine is practiced in Libya [1]. The keeping of good medical records together with clear and concise correspondence between physicians is imperative for several reasons. Not only does it avoid duplication of services and unnecessary costs, it decreases the time invested by both the patient and physician, and it fosters a collegial relationship among healthcare providers. Many times, referring physicians may not know each other. It provides a channel for them to learn from each other as well as a method for them to form professional relationships. It occurred to me that colleagues in Libya may be shy of writing referral letters or may even be phobic about disclosing their practice habits. Patient information can best be written as referral letters which summaries the patient presentation, testing, response to treatment, possible consultation, and reason for referral. The referral may be because the physician(s initially treating the patient simply have tried all treatments known to them, or they may need to refer if they lack certain diagnostic equipment necessary to continue the care. To refer the patient to colleagues simply says “we think more can be done for this patient but we may not be able to do it here; please evaluate.” It shows respect for the patient and for the colleague. No physician knows everything

  2. 18F PET with flutemetamol for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

    Science.gov (United States)

    Martínez, Gabriel; Vernooij, Robin Wm; Fuentes Padilla, Paulina; Zamora, Javier; Flicker, Leon; Bonfill Cosp, Xavier

    2017-11-22

    18 F-flutemetamol uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and the confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using some amyloid biomarkers tests like 18 F-flutemetamol. These tests, added to the MCI core clinical criteria, might increase the diagnostic test accuracy (DTA) of a testing strategy. However, the DTA of 18 F-flutemetamol to predict the progression from MCI to Alzheimer's disease dementia (ADD) or other dementias has not yet been systematically evaluated. To determine the DTA of the 18 F-flutemetamol PET scan for detecting people with MCI at time of performing the test who will clinically progress to ADD, other forms of dementia (non-ADD) or any form of dementia at follow-up. The most recent search for this review was performed in May 2017. We searched MEDLINE (OvidSP), Embase (OvidSP), PsycINFO (OvidSP), BIOSIS Citation Index (Thomson Reuters Web of Science), Web of Science Core Collection, including the Science Citation Index (Thomson Reuters Web of Science) and the Conference Proceedings Citation Index (Thomson Reuters Web of Science), LILACS (BIREME), CINAHL (EBSCOhost), ClinicalTrials.gov (https://clinicaltrials.gov), and the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) (http://www.who.int/ictrp/search/en/). We also searched ALOIS, the Cochrane Dementia & Cognitive Improvement Group's specialised register of dementia studies (http://www.medicine.ox.ac.uk/alois/). We checked the reference lists of any

  3. Correspondence passed between Einstein and Schroedinger; La correspondance entre Einstein et Schroedinger

    Energy Technology Data Exchange (ETDEWEB)

    Balibar, F. [Paris-7 Univ., 75 (France)

    1992-12-31

    The main points of the 26 year long correspondence between Einstein and Schroedinger are reviewed: from the de Broglie thesis and the Bose-Einstein statistics to the Schroedinger equation (1925-1926); from the EPR paradox to the cat parable (1935); a complete collaboration on unitary theories.

  4. Effect of Exercise and Cognitive Training on Falls and Fall-Related Factors in Older Adults With Mild Cognitive Impairment: A Systematic Review.

    Science.gov (United States)

    Lipardo, Donald S; Aseron, Anne Marie C; Kwan, Marcella M; Tsang, William W

    2017-10-01

    To evaluate the effect of exercise and cognitive training on falls reduction and on factors known to be associated with falls among community-dwelling older adults with mild cognitive impairment (MCI). Seven databases (PubMed, CINAHL, Cochrane Library, Web of Science, ProQuest, ProQuest Dissertations and Theses, Digital Dissertation Consortium) and reference lists of pertinent articles were searched. Randomized controlled trials (RCTs) on the effect of exercise, cognitive training, or a combination of both on falls and factors associated with falls such as balance, lower limb muscle strength, gait, and cognitive function among community-dwelling older adults with MCI were included. Data were extracted using the modified Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) tool. Study quality was assessed using the JBI-MAStARI appraisal instrument. Seventeen RCTs (1679 participants; mean age ± SD, 74.4±2.4y) were included. Exercise improved gait speed and global cognitive function in MCI; both are known factors associated with falls. Cognitive training alone had no significant effect on cognitive function, while combined exercise and cognitive training improved balance in MCI. Neither fall rate nor the number of fallers was reported in any of the studies included. This review suggests that exercise, and combined exercise and cognitive training improve specific factors associated with falls such as gait speed, cognitive function, and balance in MCI. Further research on the direct effect of exercise and cognitive training on the fall rate and incidence in older adults with MCI with larger sample sizes is highly recommended. Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  5. Cognitive and memory training in adults at risk of dementia: A Systematic Review

    Science.gov (United States)

    2011-01-01

    Background Effective non-pharmacological cognitive interventions to prevent Alzheimer's dementia or slow its progression are an urgent international priority. The aim of this review was to evaluate cognitive training trials in individuals with mild cognitive impairment (MCI), and evaluate the efficacy of training in memory strategies or cognitive exercises to determine if cognitive training could benefit individuals at risk of developing dementia. Methods A systematic review of eligible trials was undertaken, followed by effect size analysis. Cognitive training was differentiated from other cognitive interventions not meeting generally accepted definitions, and included both cognitive exercises and memory strategies. Results Ten studies enrolling a total of 305 subjects met criteria for cognitive training in MCI. Only five of the studies were randomized controlled trials. Meta-analysis was not considered appropriate due to the heterogeneity of interventions. Moderate effects on memory outcomes were identified in seven trials. Cognitive exercises (relative effect sizes ranged from .10 to 1.21) may lead to greater benefits than memory strategies (.88 to -1.18) on memory. Conclusions Previous conclusions of a lack of efficacy for cognitive training in MCI may have been influenced by not clearly defining the intervention. Our systematic review found that cognitive exercises can produce moderate-to-large beneficial effects on memory-related outcomes. However, the number of high quality RCTs remains low, and so further trials must be a priority. Several suggestions for the better design of cognitive training trials are provided. PMID:21942932

  6. Comparison of Two Music Training Approaches on Music and Speech Perception in Cochlear Implant Users.

    Science.gov (United States)

    Fuller, Christina D; Galvin, John J; Maat, Bert; Başkent, Deniz; Free, Rolien H

    2018-01-01

    In normal-hearing (NH) adults, long-term music training may benefit music and speech perception, even when listening to spectro-temporally degraded signals as experienced by cochlear implant (CI) users. In this study, we compared two different music training approaches in CI users and their effects on speech and music perception, as it remains unclear which approach to music training might be best. The approaches differed in terms of music exercises and social interaction. For the pitch/timbre group, melodic contour identification (MCI) training was performed using computer software. For the music therapy group, training involved face-to-face group exercises (rhythm perception, musical speech perception, music perception, singing, vocal emotion identification, and music improvisation). For the control group, training involved group nonmusic activities (e.g., writing, cooking, and woodworking). Training consisted of weekly 2-hr sessions over a 6-week period. Speech intelligibility in quiet and noise, vocal emotion identification, MCI, and quality of life (QoL) were measured before and after training. The different training approaches appeared to offer different benefits for music and speech perception. Training effects were observed within-domain (better MCI performance for the pitch/timbre group), with little cross-domain transfer of music training (emotion identification significantly improved for the music therapy group). While training had no significant effect on QoL, the music therapy group reported better perceptual skills across training sessions. These results suggest that more extensive and intensive training approaches that combine pitch training with the social aspects of music therapy may further benefit CI users.

  7. Older Adults with Mild Cognitive Impairments Show Less Driving Errors after a Multiple Sessions Simulator Training Program but Do Not Exhibit Long Term Retention.

    Science.gov (United States)

    Teasdale, Normand; Simoneau, Martin; Hudon, Lisa; Germain Robitaille, Mathieu; Moszkowicz, Thierry; Laurendeau, Denis; Bherer, Louis; Duchesne, Simon; Hudon, Carol

    2016-01-01

    The driving performance of individuals with mild cognitive impairment (MCI) is suboptimal when compared to healthy older adults. It is expected that the driving will worsen with the progression of the cognitive decline and thus, whether or not these individuals should continue to drive is a matter of debate. The aim of the study was to provide support to the claim that individuals with MCI can benefit from a training program and improve their overall driving performance in a driving simulator. Fifteen older drivers with MCI participated in five training sessions in a simulator (over a 21-day period) and in a 6-month recall session. During training, they received automated auditory feedback on their performance when an error was noted about various maneuvers known to be suboptimal in MCI individuals (for instance, weaving, omitting to indicate a lane change, to verify a blind spot, or to engage in a visual search before crossing an intersection). The number of errors was compiled for eight different maneuvers for all sessions. For the initial five sessions, a gradual and significant decrease in the number of errors was observed, indicating learning and safer driving. The level of performance, however, was not maintained at the 6-month recall session. Nevertheless, the initial learning observed opens up possibilities to undertake more regular interventions to maintain driving skills and safe driving in MCI individuals.

  8. 18F PET with florbetaben for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

    Science.gov (United States)

    Martínez, Gabriel; Vernooij, Robin Wm; Fuentes Padilla, Paulina; Zamora, Javier; Flicker, Leon; Bonfill Cosp, Xavier

    2017-11-22

    18 F-florbetaben uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using some amyloid biomarkers tests like 18 F-florbetaben. These tests, added to the MCI core clinical criteria, might increase the diagnostic test accuracy (DTA) of a testing strategy. However, the DTA of 18 F-florbetaben to predict the progression from MCI to Alzheimer's disease dementia (ADD) or other dementias has not yet been systematically evaluated. To determine the DTA of the 18 F-florbetaben PET scan for detecting people with MCI at time of performing the test who will clinically progress to ADD, other forms of dementia (non-ADD), or any form of dementia at follow-up. The most recent search for this review was performed in May 2017. We searched MEDLINE (OvidSP), Embase (OvidSP), PsycINFO (OvidSP), BIOSIS Citation Index (Thomson Reuters Web of Science), Web of Science Core Collection, including the Science Citation Index (Thomson Reuters Web of Science) and the Conference Proceedings Citation Index (Thomson Reuters Web of Science), LILACS (BIREME), CINAHL (EBSCOhost), ClinicalTrials.gov (https://clinicaltrials.gov), and the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) (http://www.who.int/ictrp/search/en/). We also searched ALOIS, the Cochrane Dementia & Cognitive Improvement Group's specialised register of dementia studies (http://www.medicine.ox.ac.uk/alois/). We checked the reference lists of any

  9. Assignment and Correspondence Tracking System - Tactical / Operational Reporting

    Data.gov (United States)

    Social Security Administration — Reporting data store for the Assignment and Correspondence Tracking System (ACT). ACT automates the assignment and tracking of correspondence processing within the...

  10. Impaired acquisition of novel grapheme-color correspondences in synesthesia

    Directory of Open Access Journals (Sweden)

    David eBrang

    2013-10-01

    Full Text Available Grapheme-color synesthesia is a neurological phenomenon in which letters and numbers (graphemes consistently evoke particular colors (e.g. A may be experienced as red. These sensations are thought to arise through the cross-activation of grapheme processing regions in the fusiform gyrus and color area V4, supported by anatomical and functional imaging. However, the developmental onset of grapheme-color synesthesia remains elusive as research in this area has largely relied on self-report of these experiences in children. One possible account suggests that synesthesia is present at or near birth and initially binds basic shapes and forms to colors, which are later refined to grapheme-color associations through experience. Consistent with this view, studies show that similarly shaped letters and numbers tend to elicit similar colors in synesthesia and that some synesthetes consciously associate basic shapes with colors; research additionally suggests that synesthetic colors can emerge for newly learned characters with repeated presentation. This model further predicts that the initial shape-color correspondences in synesthesia may persist as implicit associations, driving the acquisition of colors for novel characters. To examine the presence of latent color associations for novel characters, synesthetes and controls were trained on pre-defined associations between colors and complex shapes, on the assumption that the prescribed shape-color correspondences would on average differ from implicit synesthetic associations. Results revealed synesthetes were less accurate than controls to learn novel shape-color associations, consistent with our suggestion that implicit form-color associations conflicted with the learned pairings.

  11. Ontology Mapping Neural Network: An Approach to Learning and Inferring Correspondences among Ontologies

    Science.gov (United States)

    Peng, Yefei

    2010-01-01

    An ontology mapping neural network (OMNN) is proposed in order to learn and infer correspondences among ontologies. It extends the Identical Elements Neural Network (IENN)'s ability to represent and map complex relationships. The learning dynamics of simultaneous (interlaced) training of similar tasks interact at the shared connections of the…

  12. Computer versus Compensatory Calendar Training in Individuals with Mild Cognitive Impairment: Functional Impact in a Pilot Study.

    Science.gov (United States)

    Chandler, Melanie J; Locke, Dona E C; Duncan, Noah L; Hanna, Sherrie M; Cuc, Andrea V; Fields, Julie A; Hoffman Snyder, Charlene R; Lunde, Angela M; Smith, Glenn E

    2017-09-06

    This pilot study examined the functional impact of computerized versus compensatory calendar training in cognitive rehabilitation participants with mild cognitive impairment (MCI). Fifty-seven participants with amnestic MCI completed randomly assigned calendar or computer training. A standard care control group was used for comparison. Measures of adherence, memory-based activities of daily living (mADLs), and self-efficacy were completed. The calendar training group demonstrated significant improvement in mADLs compared to controls, while the computer training group did not. Calendar training may be more effective in improving mADLs than computerized intervention. However, this study highlights how behavioral trials with fewer than 30-50 participants per arm are likely underpowered, resulting in seemingly null findings.

  13. Performance of a sample of patients with Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD) and healthy elderly on a lexical decision test (LDT) as a measure of pre-morbid intelligence

    OpenAIRE

    Serrao, Valéria Trunkl; Brucki, Sônia Maria Dozzi; Campanholo, Kenia Repiso; Mansur, Letícia Lessa; Nitrini, Ricardo; Miotto, Eliane Correa

    2015-01-01

    Objective: The objective of this study was to describe the performance of healthy elderly patients with aging-related pathologies (MCI) and patients with AD on a lexical decision test. Methods: The study included 38 healthy elderly subjects, 61 MCI and 26 AD patients from the Neurology Department of the Hospital das Clinicas, Behavioral and Cognitive Neurology Group. The neuropsychological instruments included the episodic memory test (RAVLT), subtests from the WAIS-III (Matrix Reasoning and...

  14. A Preliminary Study on the Feasibility of Using a Virtual Reality Cognitive Training Application for Remote Detection of Mild Cognitive Impairment.

    Science.gov (United States)

    Zygouris, Stelios; Ntovas, Konstantinos; Giakoumis, Dimitrios; Votis, Konstantinos; Doumpoulakis, Stefanos; Segkouli, Sofia; Karagiannidis, Charalampos; Tzovaras, Dimitrios; Tsolaki, Magda

    2017-01-01

    It has been demonstrated that virtual reality (VR) applications can be used for the detection of mild cognitive impairment (MCI). The aim of this study is to provide a preliminary investigation on whether a VR cognitive training application can be used to detect MCI in persons using the application at home without the help of an examiner. Two groups, one of healthy older adults (n = 6) and one of MCI patients (n = 6) were recruited from Thessaloniki day centers for cognitive disorders and provided with a tablet PC with custom software enabling the self-administration of the Virtual Super Market (VSM) cognitive training exercise. The average performance (from 20 administrations of the exercise) of the two groups was compared and was also correlated with performance in established neuropsychological tests. Average performance in terms of duration to complete the given exercise differed significantly between healthy(μ  = 247.41 s/ sd = 89.006) and MCI (μ= 454.52 s/ sd = 177.604) groups, yielding a correct classification rate of 91.8% with a sensitivity and specificity of 94% and 89% respectively for MCI detection. Average performance also correlated significantly with performance in Functional Cognitive Assessment Scale (FUCAS), Test of Everyday Attention (TEA), and Rey Osterrieth Complex Figure test (ROCFT). The VR application exhibited very high accuracy in detecting MCI while all participants were able to operate the tablet and application on their own. Diagnostic accuracy was improved compared to a previous study using data from only one administration of the exercise. The results of the present study suggest that remote MCI detection through VR applications can be feasible.

  15. Comparison of different methods of spatial normalization of FDG-PET brain images in the voxel-wise analysis of MCI patients and controls

    International Nuclear Information System (INIS)

    Martino, M.E.; Villoria, J.G. de; Lacalle-Aurioles, M.; Olazaran, J.; Navarro, E.; Desco, M.; Cruz, I.; Garcia-Vazquez, V.; Carreras, J.L.

    2013-01-01

    One of the most interesting clinical applications of 18F-fluorodexyglucose (FDG) positron emission tomography (PET) imaging in neurodegenerative pathologies is that of establishing the prognosis of patients with mild cognitive impairment (MCI), some of whom have a high risk of progressing to Alzheimer's disease (AD). One method of analyzing these images is to perform statistical parametric mapping (SPM) analysis. Spatial normalization is a critical step in such an analysis. The purpose of this study was to assess the effect of using different methods of spatial normalization on the results of SPM analysis of 18F-FDG PET images by comparing patients with MCI and controls. We evaluated the results of three spatial normalization methods in an SPM analysis by comparing patients diagnosed with MCI with a group of control subjects. We tested three methods of spatial normalization: MRI-diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) and MRI-SPM8, which combine structural and functional images, and FDG-SPM8, which is based on the functional images only. The results obtained with the three methods were consistent in terms of the main pattern of functional alterations detected; namely, a bilateral reduction in glucose metabolism in the frontal and parietal cortices in the patient group. However, MRI-SPM8 also revealed differences in the left temporal cortex, and MRI-DARTEL revealed further differences in the left temporal cortex, precuneus, and left posterior cingulate. The results obtained with MRI-DARTEL were the most consistent with the pattern of changes in AD. When we compared our observations with those of previous reports, MRI-SPM8 and FDG-SPM8 seemed to show an incomplete pattern. Our results suggest that basing the spatial normalization method on functional images only can considerably impair the results of SPM analysis of 18F-FDG PET studies. (author)

  16. Predictive value of pyramidal lobe, percentage thyroid uptake and age for ablation outcome after 15 mCi fixed dose of radioiodine-131 in Graves’ disease

    International Nuclear Information System (INIS)

    Zaman, Maseeh uz; Fatima, Nosheen; Zaman, Unaiza; Sajjad, Zafar; Zaman, Areeba; Tahseen, Rabia

    2015-01-01

    The purpose was to find out the efficacy of fixed 15 mCi radioactive iodine-131 (RAI) dose and predictive values of various factors for inducing hypothyroidism in Graves’ disease (GD). Retrospective study conducted from January 2012 till August 2014. Patients with GD who had a technetium-99m thyroid scan, thyroid antibodies, received fixed 15 mCi RAI and did follow endocrine clinics for at least 6 months were selected. RAI was considered successful if within 6 months of RAI therapy patients developed hypothyroidism. Of the 370 patients with GD who had RAI during study period, 210 (57%) qualified study criteria. Mean age of patients was 48 ± 15 years with female: male ratio of 69:31, positive thyroid antibodies in 61%, means thyroid uptake of 15.09 ± 11.23%, and presence of pyramidal lobe in 40% of total population. Hypothyroidism was achieved in 161 (77%) patients while 49 (23%) patients failed to achieve it (remained either hyperthyroid or euthyroid on antithyroid medication). Patients who became hypothyroid were significantly younger with higher proportion of presence of thyroid antibodies and pyramidal lobe and lower percentage thyroid uptake than those who failed. Multiple logistic regression analysis revealed that age (odds ratio; OR = 2.074), pyramidal lobe (OR = 3.317), thyroid antibodies (OR = 8.198), and percentage thyroid uptake (OR = 3.043) were found to be significant prognostic risk factors for post-RAI hypothyroidism. Gender was found to have nonsignificant association with the development of hypothyroidism. Receiver operating characteristic analysis revealed age <42 years and thyroid uptake <15% as threshold values for the development of post-RAI hypothyroidism. We conclude that fixed (15 mCi) RAI dose is highly effective in rendering hypothyroidism in patients with GD. Age (≤42 years), thyroid uptake (≤15%) and presence of pyramidal lobe are strong predictors of hypothyroidism and must be considered for selecting optimal RAI dose

  17. The epidemiology of mild cognitive impairment (MCI and Alzheimer’s disease (AD in community-living seniors: protocol of the MemoVie cohort study, Luxembourg

    Directory of Open Access Journals (Sweden)

    Perquin Magali

    2012-07-01

    Full Text Available Abstract Background Cognitive impairment and Alzheimer’s disease (AD are increasingly considered a major public health problem. The MemoVie cohort study aims to investigate the living conditions or risk factors under which the normal cognitive capacities of the senior population in Luxembourg (≥ 65 year-old evolve (1 to mild cognitive impairment (MCI – transitory non-clinical stage – and (2 to AD. Identifying MCI and AD predictors undeniably constitutes a challenge in public health in that it would allow interventions which could protect or delay the occurrence of cognitive disorders in elderly people. In addition, the MemoVie study sets out to generate hitherto unavailable data, and a comprehensive view of the elderly population in the country. Methods/design The study has been designed with a view to highlighting the prevalence in Luxembourg of MCI and AD in the first step of the survey, conducted among participants selected from a random sample of the general population. A prospective cohort is consequently set up in the second step, and appropriate follow-up of the non-demented participants allows improving the knowledge of the preclinical stage of MCI. Case-control designs are used for cross-sectional or retrospective comparisons between outcomes and biological or clinical factors. To ensure maximal reliability of the information collected, we decided to opt for structured face to face interviews. Besides health status, medical and family history, demographic and socio-cultural information are explored, as well as education, habitat network, social behavior, leisure and physical activities. As multilingualism is expected to challenge the cognitive alterations associated with pathological ageing, it is additionally investigated. Data relative to motor function, including balance, walk, limits of stability, history of falls and accidents are further detailed. Finally, biological examinations, including ApoE genetic polymorphism are

  18. Utility training

    International Nuclear Information System (INIS)

    Villaros, P.E.; Luxo, Armando; Bruant, Jacques

    1977-01-01

    The study of operational training systems for electro-nuclear utilities may be conducted through two different approaches. A first analytical approach consists of determining, for each position of a given organization chart, the necessary qualifications required and the corresponding complementary training to be provided. This approach applies preferentially to existing classical systems which are converted to nuclear operation with objectives of minimum structural changes and conservation of maximum efficiency. A second synthetical approach consists of determining the specific characteristics of nuclear plant operation, then, of deducting the training contingencies and the optimized organization chart of the plant, while taking into account, at each step, the parameters linked to local conditions. This last approach is studied in some detail in the present paper, taking advantage of its better suitability to the problems raised at the first stage of an electro-nuclear program development. In this respect, the possibility offered by this apprach to coordinate the training system of a given nuclear power station personnel with the overall problem of developing a skilled industrial labor force in the country, may lead to reconsideration of some usual priorities in the economy of operation of the nuclear power plant

  19. A logical correspondence between natural semantics and abstract machines

    DEFF Research Database (Denmark)

    Simmons, Robert J.; Zerny, Ian

    2013-01-01

    We present a logical correspondence between natural semantics and abstract machines. This correspondence enables the mechanical and fully-correct construction of an abstract machine from a natural semantics. Our logical correspondence mirrors the Reynolds functional correspondence, but we...... manipulate semantic specifications encoded in a logical framework instead of manipulating functional programs. Natural semantics and abstract machines are instances of substructural operational semantics. As a byproduct, using a substructural logical framework, we bring concurrent and stateful models...

  20. 48 CFR 252.225-7041 - Correspondence in English.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Correspondence in English... of Provisions And Clauses 252.225-7041 Correspondence in English. As prescribed in 225.1103(2), use the following clause: Correspondence in English (JUN 1997) The Contractor shall ensure that all...

  1. Identificação do gene mcyA em florações naturais de Radiocystis fernandoi, em um tributário do reservatório de Rosana, Brasil = Identification of the mcyA gene in natural blooms of Radiocystis fernandoi from a tributary of the Rosana reservoir, Brazil

    Directory of Open Access Journals (Sweden)

    Iraúza Arroteia Fonseca

    2011-07-01

    Full Text Available As cianobactérias são conhecidamente produtoras de toxinas. Dentro de uma mesma espécie, podemos encontrar variedades tóxicas e não-tóxicas, impossíveis de diferenciação apenas pela morfologia. A principal toxina produzida pelas cianobactérias é a microcistina. Esta proteína é biossintetizada por um grupo de genes conhecidos como mcy. A detecção destes genes a partir de PCR permite a distinção das variedades tóxicas e nãotóxicas. Desse modo, o objetivo desse trabalho foi investigar a ocorrência de florações produtoras de toxinas em um rio tributário do reservatório de Rosana, via amplificação do gene mcyA por PCR. Foram coletadas duas amostras de água da subsuperfície. As duas amostras coletadas no rio do Corvo foram dominadas pela espécie Radiocystis fernandoi e apresentaram resultados positivos para a presença do gene mcyA, confirmando o potencial tóxico dessa espécie. Os resultados representam alerta sobre a qualidade da água do rio do Corvo. A técnica PCR foi eficiente para a rápida detecção de cianobactérias produtoras detoxinas, inclusive podendo ser utilizada antes mesmo do agravamento das condições ambientais pela produção de toxinas, além de apresentar baixo custo.Cyanobacterias are known as toxin producers. Within the same species, toxic and non-toxic varieties can be found and it is impossible to differentiate them only by morphology. The most important toxinproduced by cyanobacteria is microcystin. This protein is synthesized by a cluster of genes known as mcy. The detection of these genes by PCR allows the differentiation of the producing toxin strain from the non-producing toxin strain. Thus, the goal of this work was to investigate the occurrence of toxigenic blooms of cyanobacteria in the Corvo River through PCR amplification of mcyA gene. For this, two samples of blooms of cyanobacteria were collected in Corvo River. Both samples were dominated by Radiocystis fernandoi and presented

  2. Quantum-classical correspondence in the vicinity of periodic orbits

    Science.gov (United States)

    Kumari, Meenu; Ghose, Shohini

    2018-05-01

    Quantum-classical correspondence in chaotic systems is a long-standing problem. We describe a method to quantify Bohr's correspondence principle and calculate the size of quantum numbers for which we can expect to observe quantum-classical correspondence near periodic orbits of Floquet systems. Our method shows how the stability of classical periodic orbits affects quantum dynamics. We demonstrate our method by analyzing quantum-classical correspondence in the quantum kicked top (QKT), which exhibits both regular and chaotic behavior. We use our correspondence conditions to identify signatures of classical bifurcations even in a deep quantum regime. Our method can be used to explain the breakdown of quantum-classical correspondence in chaotic systems.

  3. Basic Disaster Life Support (BDLS) Training Improves First Responder Confidence to Face Mass-Casualty Incidents in Thailand.

    Science.gov (United States)

    Kuhls, Deborah A; Chestovich, Paul J; Coule, Phillip; Carrison, Dale M; Chua, Charleston M; Wora-Urai, Nopadol; Kanchanarin, Tavatchai

    2017-10-01

    Medical response to mass-casualty incidents (MCIs) requires specialized training and preparation. Basic Disaster Life Support (BDLS) is a course designed to prepare health care workers for a MCI. The purpose of this study was to evaluate the confidence of health care professionals in Thailand to face a MCI after participating in a BDLS course. Basic Disaster Life Support was taught to health care professionals in Thailand in July 2008. Demographics and medical experience were recorded, and participants rated their confidence before and after the course using a five-point Likert scale in 11 pertinent MCI categories. Survey results were compiled and compared with PBasic Disaster Life Support significantly improves confidence to respond to MCI situations, but nurses and active duty military benefit the most from the course. Future courses should focus on these groups to prepare for MCIs. Kuhls DA , Chestovich PJ , Coule P , Carrison DM , Chua CM , Wora-Urai N , Kanchanarin T . Basic Disaster Life Support (BDLS) training improves first responder confidence to face mass-casualty incidents in Thailand. Prehosp Disaster Med. 2017;32(5):492-500 .

  4. Tsuruga: 1 ton, some 10 mCi of rad-liquid leaks out to the sea, no environmental and human costs

    International Nuclear Information System (INIS)

    1981-01-01

    In the Tsuruga Nuclear Power Station of Japan Atomic Power Co., the leakage of radioactivity from the site into the sea occurred, as follows. Due to a valve being left open on March 8, 1981, the overflow of liquid waste from the filter sludge storage tank into the laundry waste filtering room took place. A part of it leaked through the floor into the general underground waterway. The amount was estimated to be one ton with some 10 mCi. The incident is reviewed with the following topics: nobody expected rad-material in the waterway with the leakage from a filter sludge tank; construction, human and management mistakes were revealed in the survey; no environmental impact, with the defect peculiar to Tsuruga; JAPCO executives assume the responsibility; JAPCO and regulatory authorities need review. (Mori, K.)

  5. Language Training: English Training

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Language Training Françoise Benz tel. 73127 language.training@cern.ch General and Professional English Courses The next session will take place: from 1st March to 25 June 2004 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957.

  6. Language Training: English Training

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch General and Professional English Courses The next session will take place: from 1st March to 25 June 2004 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957.

  7. Energy aspect of the correspondence principle in gravitation theory

    International Nuclear Information System (INIS)

    Mitskevich, N.V.; Nesterov, A.I.

    1976-01-01

    The correspondence of different definitions of invariant values in the general relativity theory with the Newton theory is considered. The analysis is carried out in the system of reference of a single Fermi-observer. It turns out that of the values considered the Papapetru pseudotensor only satisfies the correspondence principle

  8. 46 CFR 159.001-5 - Correspondence and applications.

    Science.gov (United States)

    2010-10-01

    ....001-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND... Correspondence and applications. Unless otherwise specified, all correspondence and applications in connection with approval and testing of equipment and materials must be addressed to: Commandant (CG-5214), U.S...

  9. Simultaneous Two-Way Clustering of Multiple Correspondence Analysis

    Science.gov (United States)

    Hwang, Heungsun; Dillon, William R.

    2010-01-01

    A 2-way clustering approach to multiple correspondence analysis is proposed to account for cluster-level heterogeneity of both respondents and variable categories in multivariate categorical data. Specifically, in the proposed method, multiple correspondence analysis is combined with k-means in a unified framework in which "k"-means is…

  10. The Bohr-Heisenberg correspondence principle viewed from phase space

    DEFF Research Database (Denmark)

    Dahl, Jens Peder

    2002-01-01

    Phase-space representations play an increasingly important role in several branches of physics. Here, we review the author's studies of the Bohr-Heisenberg correspondence principle within the Weyl-Wigner phase-space representation. The analysis leads to refined correspondence rules that can...

  11. Correspondence and canonicity in non-classical logic

    NARCIS (Netherlands)

    Sourabh, S.

    2015-01-01

    In this thesis we study correspondence and canonicity for non-classical logic using algebraic and order-topological methods. Correspondence theory is aimed at answering the question of how precisely modal, first-order, second-order languages interact and overlap in their shared semantic environment.

  12. 37 CFR 7.3 - Correspondence must be in English.

    Science.gov (United States)

    2010-07-01

    ... English. 7.3 Section 7.3 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... English. International applications and registrations, requests for extension of protection and all other related correspondence with the Office must be in English. The Office will not process correspondence that...

  13. Introduction to the AdS/CFT correspondence

    NARCIS (Netherlands)

    de Boer, J.; Baulieu, L.; Benakli, K.; Douglas, M.R.; Mansoulié, B.; Rabinovici, E.; Cugliandolo, L.F.

    2015-01-01

    This chapter provides a summary of some of the most important aspects of the AdS/CFT correspondence, together with pointers to some of the vast number of papers that have been published on this subject. The AdS/CFT correspondence is one of the most exciting discoveries in theoretical physics of the

  14. 12 CFR 206.5 - Capital levels of correspondents.

    Science.gov (United States)

    2010-01-01

    ... not identical to the definition of that term as used for the purposes of the prompt corrective action... capital levels. A bank shall obtain information to demonstrate that a correspondent is at least adequately..., Thrift Financial Report, financial statement, or bank rating report for the correspondent. For a foreign...

  15. Automatic Camera Calibration Using Multiple Sets of Pairwise Correspondences.

    Science.gov (United States)

    Vasconcelos, Francisco; Barreto, Joao P; Boyer, Edmond

    2018-04-01

    We propose a new method to add an uncalibrated node into a network of calibrated cameras using only pairwise point correspondences. While previous methods perform this task using triple correspondences, these are often difficult to establish when there is limited overlap between different views. In such challenging cases we must rely on pairwise correspondences and our solution becomes more advantageous. Our method includes an 11-point minimal solution for the intrinsic and extrinsic calibration of a camera from pairwise correspondences with other two calibrated cameras, and a new inlier selection framework that extends the traditional RANSAC family of algorithms to sampling across multiple datasets. Our method is validated on different application scenarios where a lack of triple correspondences might occur: addition of a new node to a camera network; calibration and motion estimation of a moving camera inside a camera network; and addition of views with limited overlap to a Structure-from-Motion model.

  16. Cognitive and Neural Effects of Vision-Based Speed-of-Processing Training in Older Adults with Amnestic Mild Cognitive Impairment: A Pilot Study.

    Science.gov (United States)

    Lin, Feng; Heffner, Kathi L; Ren, Ping; Tivarus, Madalina E; Brasch, Judith; Chen, Ding-Geng; Mapstone, Mark; Porsteinsson, Anton P; Tadin, Duje

    2016-06-01

    To examine the cognitive and neural effects of vision-based speed-of-processing (VSOP) training in older adults with amnestic mild cognitive impairment (aMCI) and contrast those effects with an active control (mental leisure activities (MLA)). Randomized single-blind controlled pilot trial. Academic medical center. Individuals with aMCI (N = 21). Six-week computerized VSOP training. Multiple cognitive processing measures, instrumental activities of daily living (IADLs), and two resting state neural networks regulating cognitive processing: central executive network (CEN) and default mode network (DMN). VSOP training led to significantly greater improvements in trained (processing speed and attention: F1,19  = 6.61, partial η(2)  = 0.26, P = .02) and untrained (working memory: F1,19  = 7.33, partial η(2)  = 0.28, P = .01; IADLs: F1,19  = 5.16, partial η(2)  = 0.21, P = .03) cognitive domains than MLA and protective maintenance in DMN (F1, 9  = 14.63, partial η(2)  = 0.62, P = .004). VSOP training, but not MLA, resulted in a significant improvement in CEN connectivity (Z = -2.37, P = .02). Target and transfer effects of VSOP training were identified, and links between VSOP training and two neural networks associated with aMCI were found. These findings highlight the potential of VSOP training to slow cognitive decline in individuals with aMCI. Further delineation of mechanisms underlying VSOP-induced plasticity is necessary to understand in which populations and under what conditions such training may be most effective. © 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

  17. Breaking object correspondence across saccadic eye movements deteriorates object recognition

    Directory of Open Access Journals (Sweden)

    Christian H. Poth

    2015-12-01

    Full Text Available Visual perception is based on information processing during periods of eye fixations that are interrupted by fast saccadic eye movements. The ability to sample and relate information on task-relevant objects across fixations implies that correspondence between presaccadic and postsaccadic objects is established. Postsaccadic object information usually updates and overwrites information on the corresponding presaccadic object. The presaccadic object representation is then lost. In contrast, the presaccadic object is conserved when object correspondence is broken. This helps transsaccadic memory but it may impose attentional costs on object recognition. Therefore, we investigated how breaking object correspondence across the saccade affects postsaccadic object recognition. In Experiment 1, object correspondence was broken by a brief postsaccadic blank screen. Observers made a saccade to a peripheral object which was displaced during the saccade. This object reappeared either immediately after the saccade or after the blank screen. Within the postsaccadic object, a letter was briefly presented (terminated by a mask. Observers reported displacement direction and letter identity in different blocks. Breaking object correspondence by blanking improved displacement identification but deteriorated postsaccadic letter recognition. In Experiment 2, object correspondence was broken by changing the object’s contrast-polarity. There were no object displacements and observers only reported letter identity. Again, breaking object correspondence deteriorated postsaccadic letter recognition. These findings identify transsaccadic object correspondence as a key determinant of object recognition across the saccade. This is in line with the recent hypothesis that breaking object correspondence results in separate representations of presaccadic and postsaccadic objects which then compete for limited attentional processing resources (Schneider, 2013. Postsaccadic

  18. Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment.

    Science.gov (United States)

    Peter, Jessica; Schumacher, Lena V; Landerer, Verena; Abdulkadir, Ahmed; Kaller, Christoph P; Lahr, Jacob; Klöppel, Stefan

    2018-01-01

    In mild cognitive impairment (MCI), small benefits from cognitive training were observed for memory functions but there appears to be great variability in the response to treatment. Our study aimed to improve the characterization and selection of those participants who will benefit from cognitive intervention. We evaluated the predictive value of disease-specific biological factors for the outcome after cognitive training in MCI (n = 25) and also considered motivation of the participants. We compared the results of the cognitive intervention group with two independent control groups of MCI patients (local memory clinic, n = 20; ADNI cohort, n = 302). The primary outcome measure was episodic memory as measured by verbal delayed recall of a 10-word list. Episodic memory remained stable after treatment and slightly increased 6 months after the intervention. In contrast, in MCI patients who did not receive an intervention, episodic memory significantly decreased during the same time interval. A larger left entorhinal cortex predicted more improvement in episodic memory after treatment and so did higher levels of motivation. Adding disease-specific biological factors significantly improved the prediction of training-related change compared to a model based simply on age and baseline performance. Bootstrapping with resampling (n = 1000) verified the stability of our finding. Cognitive training might be particularly helpful in individuals with a bigger left entorhinal cortex as individuals who did not benefit from intervention showed 17% less volume in this area. When extended to alternative treatment options, stratification based on disease-specific biological factors is a useful step towards individualized medicine.

  19. Computer-Based Cognitive Training for Mild Cognitive Impairment: Results from a Pilot Randomized, Controlled Trial

    OpenAIRE

    Barnes, Deborah E.; Yaffe, Kristine; Belfor, Nataliya; Jagust, William J.; DeCarli, Charles; Reed, Bruce R.; Kramer, Joel H.

    2009-01-01

    We performed a pilot randomized, controlled trial of intensive, computer-based cognitive training in 47 subjects with mild cognitive impairment (MCI). The intervention group performed exercises specifically designed to improve auditory processing speed and accuracy for 100 minutes/day, 5 days/week for 6 weeks; the control group performed more passive computer activities (reading, listening, visuospatial game) for similar amounts of time. Subjects had a mean age of 74 years and 60% were men; 7...

  20. Pseudo-supersymmetry and the domain-wall/cosmology correspondence

    International Nuclear Information System (INIS)

    Skenderis, Kostas; Townsend, Paul K

    2007-01-01

    The correspondence between domain-wall and cosmological solutions of gravity coupled to scalar fields is explained. Any domain-wall solutions that admit a Killing spinor are shown to correspond to a cosmology that admits a pseudo-Killing spinor; whereas the Killing spinor obeys a Dirac-type equation with Hermitian 'mass'-matrix, the corresponding pseudo-Killing spinor obeys a Dirac-type equation with a anti-Hermitian 'mass'-matrix. We comment on some implications of (pseudo)supersymmetry

  1. Weyl-Wigner correspondence in two space dimensions

    DEFF Research Database (Denmark)

    Dahl, Jens Peder; Varro, S.; Wolf, A.

    2007-01-01

    We consider Wigner functions in two space dimensions. In particular, we focus on Wigner functions corresponding to energy eigenstates of a non-relativistic particle moving in two dimensions in the absence of a potential. With the help of the Weyl-Wigner correspondence we first transform...... the eigenvalue equations for energy and angular momentum into phase space. As a result we arrive at partial differential equations in phase space which determine the corresponding Wigner function. We then solve the resulting equations using appropriate coordinates....

  2. (Anti)symmetric multivariate exponential functions and corresponding Fourier transforms

    International Nuclear Information System (INIS)

    Klimyk, A U; Patera, J

    2007-01-01

    We define and study symmetrized and antisymmetrized multivariate exponential functions. They are defined as determinants and antideterminants of matrices whose entries are exponential functions of one variable. These functions are eigenfunctions of the Laplace operator on the corresponding fundamental domains satisfying certain boundary conditions. To symmetric and antisymmetric multivariate exponential functions there correspond Fourier transforms. There are three types of such Fourier transforms: expansions into the corresponding Fourier series, integral Fourier transforms and multivariate finite Fourier transforms. Eigenfunctions of the integral Fourier transforms are found

  3. Dimensions of cultural consumption among tourists : Multiple correspondence analysis

    NARCIS (Netherlands)

    Richards, G.W.; van der Ark, L.A.

    2013-01-01

    The cultural tourism market has diversified and fragmented into many different niches. Previous attempts to segment cultural tourists have been largely unidimensional, failing to capture the complexity of cultural production and consumption. We employ multiple correspondence analysis to visualize

  4. Correspondence between Grammatical Categories and Grammatical Functions in Chinese.

    Science.gov (United States)

    Tan, Fu

    1993-01-01

    A correspondence is shown between grammatical categories and grammatical functions in Chinese. Some syntactic properties distinguish finite verbs from nonfinite verbs, nominals from other categories, and verbs from other categories. (Contains seven references.) (LB)

  5. Twisted vertex algebras, bicharacter construction and boson-fermion correspondences

    International Nuclear Information System (INIS)

    Anguelova, Iana I.

    2013-01-01

    The boson-fermion correspondences are an important phenomena on the intersection of several areas in mathematical physics: representation theory, vertex algebras and conformal field theory, integrable systems, number theory, cohomology. Two such correspondences are well known: the types A and B (and their super extensions). As a main result of this paper we present a new boson-fermion correspondence of type D-A. Further, we define a new concept of twisted vertex algebra of order N, which generalizes super vertex algebra. We develop the bicharacter construction which we use for constructing classes of examples of twisted vertex algebras, as well as for deriving formulas for the operator product expansions, analytic continuations, and normal ordered products. By using the underlying Hopf algebra structure we prove general bicharacter formulas for the vacuum expectation values for two important groups of examples. We show that the correspondences of types B, C, and D-A are isomorphisms of twisted vertex algebras

  6. Privacy Impact Assessment for the Correspondence Management System

    Science.gov (United States)

    The Correspondence Management System collects basic contact information (name, address, e-mail and phone number). Learn how this data is collected, how it will be used, access to the data, the purpose of data collection, and record retention policies.

  7. PWR surveillance based on correspondence between empirical models and physical

    International Nuclear Information System (INIS)

    Zwingelstein, G.; Upadhyaya, B.R.; Kerlin, T.W.

    1976-01-01

    An on line surveillance method based on the correspondence between empirical models and physicals models is proposed for pressurized water reactors. Two types of empirical models are considered as well as the mathematical models defining the correspondence between the physical and empirical parameters. The efficiency of this method is illustrated for the surveillance of the Doppler coefficient for Oconee I (an 886 MWe PWR) [fr

  8. PEMBUATAN SUMBER RADIASI GAMMA 137Cs DENGAN AKTIVITAS 20 mCi DARI PEB U3Si2-Al PASCA IRADIASI DALAM CONTAINER STAINLESS STEEL

    Directory of Open Access Journals (Sweden)

    Aslina Br. Ginting

    2016-03-01

    Full Text Available ABSTRAK PEMBUATAN SUMBER RADIASI GAMMA ISOTOP 137Cs DENGAN AKTIVITAS 20 mCi DARI PEB U3Si2-Al PASCA IRADIASI DALAM CONTAINER STAINLESS STEEL. Kegiatan uji pasca iradiasi pelat elemen bakar (PEB U3Si2-Al banyak menghasilkan larutan dengan keaktifan yang sangat tinggi. Larutan tersebut mengandung isotop 137Cs, uranium serta transuranium yang mempunyai waktu paroh panjang dan berbahaya bagi lingkungan. Namun larutan tersebut memiliki nilai ekonomis tinggi karena dapat dimanfaatkan sebagai bahan baku untuk pembuatan sumber radiasi sinar gamma isotop 137Cs. Hal ini dapat membantu bidang industri dalam memenuhi kebutuhan sumber radioaktif dalam negeri karena selama ini kebutuhan isotop 137Cs di Indonesia masih tergantung dari industri luar negeri. Selain itu, pengadaan dan transportasi isotop 137Cs dari luar negeri serta dalam penggunaannya memerlukan persyaratan yang cukup ketat dari Badan Pengawas Tenaga Nuklir Nasional (BAPETEN, sehingga menyebabkan harga isotop 137Cs menjadi mahal sampai di Indonesia. Dengan alasan tersebut, BATAN sebagai lembaga litbang nuklir di Indonesia perlu mempelajari pembuatan sumber radiasi gamma isotop 137Cs dari larutan hasil pengujian bahan bakar nuklir U3Si2-Al pasca iradiasi. Manfaat isotop 137Cs sangat luas antara lain digunakan dalam menganalisis sampel lingkungan, industri migas, konstruksi, radiografi, perikanan, rumah sakit dan pertambangan. Pembuatan sumber radiasi gamma isotop 137Cs dimulai dari pengumpulan larutan hasil pengujian PEB U3Si2-Al. Larutan larutan hasil pengujian mengandung isotop 137Cs dan isotop lainnya dikumpulkan menjadi satu dalam botol dengan volume 65 mL. Pemisahan isotop 137Cs dari hasil fisi lainnya dilakukan dengan metode penukar kation menggunakan zeolit Lampung dengan berat 45 gr. Hasil pemisahan diperoleh 137Cs-zeolit dalam fasa padat dan isotop lainnya berada dalam fasa cair. Padatan137Cs-zeolit kering kemudian kemudian ditimbang dan diukur aktivitasnya menggunakan spektrometer

  9. Radioiodine therapy of differentiated thyroid cancer: radiologic impact of out-patient treatment with 100 to 150 mCi Iodine-131 activities; Radioiodoterapia do carcinoma diferenciado da tireoide: impacto radiologico da liberacao hospitalar de pacientes com atividades entre 100 e 150 mCi de iodo-131

    Energy Technology Data Exchange (ETDEWEB)

    Sapienza, Marcelo Tatit; Willegaignon, Jose; Ono, Carla Rachel; Watanabe, Tomoco; Guimaraes, Maria Ines Calil Cury; Buchpiguel, Carlos Alberto [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Medicina. Servico de Medicina Nuclear; Gutterres, Ricardo Fraga; Marechal, Maria Helena da Hora [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2009-07-01

    Purpose: To evaluate exposure and dosimetry to family members and environment due to outpatient radioiodine therapy of differentiated thyroid carcinoma. Methods: Twenty patients were treated with 100-150 mCi of iodine-131 on an out-patient basis. Family members dosimetry (n = 27) and potential doses inside the house were measured with thermoluminescent dosimeters. Surface contamination and radioactive wastes were also monitored. Results: Less than 1.0 mSv doses were found in 26 co-habitants and 2.8 mSv in a single case (inferior to the acceptable value of 5.0 mSv/procedure). Potential doses in the houses were inferior to 0.25 mSv, excluding the patients bedroom (mean value = 0.69 mSv). Surface contamination (mean = 4.2 Bq.cm{sup -2}) were below clearance levels. Radioactive wastes generated had a volume of 2.5 liters and a total activity estimated in 90 {mu}Ci, with a calculated exposure close to the background radiation levels. Conclusions: No radiological impact was detected after iodine therapy with 100-150 mCi on an out-patient basis followed by experienced professionals. (author)

  10. Automatic correspondence detection in mammogram and breast tomosynthesis images

    Science.gov (United States)

    Ehrhardt, Jan; Krüger, Julia; Bischof, Arpad; Barkhausen, Jörg; Handels, Heinz

    2012-02-01

    Two-dimensional mammography is the major imaging modality in breast cancer detection. A disadvantage of mammography is the projective nature of this imaging technique. Tomosynthesis is an attractive modality with the potential to combine the high contrast and high resolution of digital mammography with the advantages of 3D imaging. In order to facilitate diagnostics and treatment in the current clinical work-flow, correspondences between tomosynthesis images and previous mammographic exams of the same women have to be determined. In this paper, we propose a method to detect correspondences in 2D mammograms and 3D tomosynthesis images automatically. In general, this 2D/3D correspondence problem is ill-posed, because a point in the 2D mammogram corresponds to a line in the 3D tomosynthesis image. The goal of our method is to detect the "most probable" 3D position in the tomosynthesis images corresponding to a selected point in the 2D mammogram. We present two alternative approaches to solve this 2D/3D correspondence problem: a 2D/3D registration method and a 2D/2D mapping between mammogram and tomosynthesis projection images with a following back projection. The advantages and limitations of both approaches are discussed and the performance of the methods is evaluated qualitatively and quantitatively using a software phantom and clinical breast image data. Although the proposed 2D/3D registration method can compensate for moderate breast deformations caused by different breast compressions, this approach is not suitable for clinical tomosynthesis data due to the limited resolution and blurring effects perpendicular to the direction of projection. The quantitative results show that the proposed 2D/2D mapping method is capable of detecting corresponding positions in mammograms and tomosynthesis images automatically for 61 out of 65 landmarks. The proposed method can facilitate diagnosis, visual inspection and comparison of 2D mammograms and 3D tomosynthesis images for

  11. Language Training: French Training

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch General and Professional French Courses The next session will take place from 26 April to 02 July 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 April to 02 July 2004. This course is designed for people with a good level of s...

  12. Language Training: French Training

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch General and Professional French Courses The next session will take place from 26 April to 02 July 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 April to 02 July 2004. This course is designed for people with a good level...

  13. Sensor-based balance training with motion feedback in people with mild cognitive impairment.

    Science.gov (United States)

    Schwenk, Michael; Sabbagh, Marwan; Lin, Ivy; Morgan, Pharah; Grewal, Gurtej S; Mohler, Jane; Coon, David W; Najafi, Bijan

    2016-01-01

    Some individuals with mild cognitive impairment (MCI) experience not only cognitive deficits but also a decline in motor function, including postural balance. This pilot study sought to estimate the feasibility, user experience, and effects of a novel sensor-based balance training program. Patients with amnestic MCI (mean age 78.2 yr) were randomized to an intervention group (IG, n = 12) or control group (CG, n = 10). The IG underwent balance training (4 wk, twice a week) that included weight shifting and virtual obstacle crossing. Real-time visual/audio lower-limb motion feedback was provided from wearable sensors. The CG received no training. User experience was measured by a questionnaire. Postintervention effects on balance (center of mass sway during standing with eyes open [EO] and eyes closed), gait (speed, variability), cognition, and fear of falling were measured. Eleven participants (92%) completed the training and expressed fun, safety, and helpfulness of sensor feedback. Sway (EO, p = 0.04) and fear of falling (p = 0.02) were reduced in the IG compared to the CG. Changes in other measures were nonsignificant. Results suggest that the sensor-based training paradigm is well accepted in the target population and beneficial for improving postural control. Future studies should evaluate the added value of the sensor-based training compared to traditional training.

  14. Hardware Design Considerations for Edge-Accelerated Stereo Correspondence Algorithms

    Directory of Open Access Journals (Sweden)

    Christos Ttofis

    2012-01-01

    Full Text Available Stereo correspondence is a popular algorithm for the extraction of depth information from a pair of rectified 2D images. Hence, it has been used in many computer vision applications that require knowledge about depth. However, stereo correspondence is a computationally intensive algorithm and requires high-end hardware resources in order to achieve real-time processing speed in embedded computer vision systems. This paper presents an overview of the use of edge information as a means to accelerate hardware implementations of stereo correspondence algorithms. The presented approach restricts the stereo correspondence algorithm only to the edges of the input images rather than to all image points, thus resulting in a considerable reduction of the search space. The paper highlights the benefits of the edge-directed approach by applying it to two stereo correspondence algorithms: an SAD-based fixed-support algorithm and a more complex adaptive support weight algorithm. Furthermore, we present design considerations about the implementation of these algorithms on reconfigurable hardware and also discuss issues related to the memory structures needed, the amount of parallelism that can be exploited, the organization of the processing blocks, and so forth. The two architectures (fixed-support based versus adaptive-support weight based are compared in terms of processing speed, disparity map accuracy, and hardware overheads, when both are implemented on a Virtex-5 FPGA platform.

  15. Fluid/gravity correspondence and the CFM black brane solutions

    Energy Technology Data Exchange (ETDEWEB)

    Casadio, R. [Universita di Bologna, Dipartimento di Fisica e Astronomia, Bologna (Italy); I.N.F.N., Sezione di Bologna, Bologna (Italy); Cavalcanti, R.T. [Universita di Bologna, Dipartimento di Fisica e Astronomia, Bologna (Italy); Universidade Federal do ABC-UFABC, Centro de Ciencias Naturais e Humanas, Santo Andre (Brazil); Rocha, Roldao da [Universidade Federal do ABC-UFABC, Centro de Matematica, Computacao e Cognicao, Santo Andre (Brazil)

    2016-10-15

    We consider the lower bound for the shear viscosity-to-entropy density ratio, obtained from the fluid/gravity correspondence, in order to constrain the post-Newtonian parameter of brane-world metrics. In particular, we analyse the Casadio-Fabbri-Mazzacurati (CFM) effective solutions for the gravity side of the correspondence and argue that including higher-order terms in the hydrodynamic expansion can lead to a full agreement with the experimental bounds, for the Eddington-Robertson-Schiff post-Newtonian parameter in the CFM metrics. This lends further support to the physical relevance of the viscosity-to-entropy ratio lower bound and fluid/gravity correspondence. Hence we show that CFM black branes are, effectively, Schwarzschild black branes. (orig.)

  16. ODE/IM correspondence and the Argyres-Douglas theory

    Science.gov (United States)

    Ito, Katsushi; Shu, Hongfei

    2017-08-01

    We study the quantum spectral curve of the Argyres-Douglas theories in the Nekrasov-Sahashvili limit of the Omega-background. Using the ODE/IM correspondence we investigate the quantum integrable model corresponding to the quantum spectral curve. We show that the models for the A 2 N -type theories are non-unitary coset models ( A 1)1 × ( A 1) L /( A 1) L+1 at the fractional level L=2/2N+1-2 , which appear in the study of the 4d/2d correspondence of N = 2 superconformal field theories. Based on the WKB analysis, we clarify the relation between the Y-functions and the quantum periods and study the exact Bohr-Sommerfeld quantization condition for the quantum periods. We also discuss the quantum spectral curves for the D and E type theories.

  17. On the correspondence between CAL and lagged cohort life expectancy

    Directory of Open Access Journals (Sweden)

    Michel Guillot

    2011-04-01

    Full Text Available It has been established that under certain mortality assumptions, the current value of the Cross-sectional Average length of Life (CAL is equal to the life expectancy for the cohort currently reaching its life expectancy. This correspondence is important, because the life expectancy for the cohort currently reaching its life expectancy, or lagged cohort life expectancy (LCLE, has been discussed in the tempo literature as a summary mortality measure of substantive interest. In this paper, we build on previous work by evaluating the extent to which the correspondence holds in actual populations. We also discuss the implications of the CAL-LCLE correspondence (or lack thereof for using CAL as a measure of cohort life expectancy, and for understanding the connection between CAL, LCLE, and underlying period mortality conditions.

  18. Quantum hair and the string-black hole correspondence

    CERN Document Server

    Veneziano, Gabriele

    2013-01-01

    We consider a thought experiment in which an energetic massless string probes a "stringhole" (a heavy string lying on the correspondence curve between strings and black holes) at large enough impact parameter for the regime to be under theoretical control. The corresponding, explicitly unitary, $S$-matrix turns out to be perturbatively sensitive to the microstate of the stringhole: in particular, at leading order in $l_s/b$, it depends on a projection of the stringhole's Lorentz-contracted quadrupole moment. The string-black hole correspondence is therefore violated if one assumes quantum hair to be exponentially suppressed as a function of black-hole entropy. Implications for the information paradox are briefly discussed.

  19. Fermions in nonrelativistic AdS/CFT correspondence

    International Nuclear Information System (INIS)

    Akhavan, Amin; Alishahiha, Mohsen; Davody, Ali; Vahedi, Ali

    2009-01-01

    We extend the nonrelativistic AdS/CFT correspondence to the fermionic fields. In particular, we study the two point function of a fermionic operator in nonrelativistic CFTs by making use of a massive fermion propagating in geometries with Schroedinger group isometry. Although the boundary of the geometries with Schroedinger group isometry differ from that in AdS geometries where the dictionary of AdS/CFT is established, using the general procedure of AdS/CFT correspondence, we see that the resultant two point function has the expected form for fermionic operators in nonrelativistic CFTs, though a nontrivial regularization may be needed.

  20. ODE/IM correspondence and modified affine Toda field equations

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Katsushi; Locke, Christopher

    2014-08-15

    We study the two-dimensional affine Toda field equations for affine Lie algebra g{sup ^} modified by a conformal transformation and the associated linear equations. In the conformal limit, the associated linear problem reduces to a (pseudo-)differential equation. For classical affine Lie algebra g{sup ^}, we obtain a (pseudo-)differential equation corresponding to the Bethe equations for the Langlands dual of the Lie algebra g, which were found by Dorey et al. in study of the ODE/IM correspondence.

  1. Quantum-classical correspondence in steady states of nonadiabatic systems

    International Nuclear Information System (INIS)

    Fujii, Mikiya; Yamashita, Koichi

    2015-01-01

    We first present nonadiabatic path integral which is exact formulation of quantum dynamics in nonadiabatic systems. Then, by applying the stationary phase approximations to the nonadiabatic path integral, a semiclassical quantization condition, i.e., quantum-classical correspondence, for steady states of nonadiabatic systems is presented as a nonadiabatic trace formula. The present quantum-classical correspondence indicates that a set of primitive hopping periodic orbits, which are invariant under time evolution in the phase space of the slow degree of freedom, should be quantized. The semiclassical quantization is then applied to a simple nonadiabatic model and accurately reproduces exact quantum energy levels

  2. Gravitational collapse disturbs the dS/CFT correspondence?

    International Nuclear Information System (INIS)

    Iwashita, Yukinori; Yoshino, Hirotaka; Shiromizu, Tetsuya

    2005-01-01

    We study the gravitational collapse in five-dimensional de Sitter (dS) spacetime and discuss the existence of the conformal boundaries at future timelike infinity (I + ) from the perspective of the dS/conformal field theories correspondence. We investigate the motion of a spherical dust shell and the black-hole area bounds. The latter includes the analysis of the trapping horizon and the initial data with spindle-shaped matter distribution. In all the above analyses we find the evidences that guarantee the existence of the conformal boundaries at future timelike infinity which may be essential to apply the dS/conformal field theories correspondence

  3. 78 FR 52431 - Amendments to ONRR's Service of Official Correspondence

    Science.gov (United States)

    2013-08-23

    ... service is effected; (3) Private mailing service (e.g., United Parcel Service, or Federal Express), with...-2013-0001; DS63610300 DR2PS0000.CH7000 134D0102R2] RIN 1012-AA14 Amendments to ONRR's Service of...), Interior. ACTION: Direct final rule. SUMMARY: This rule will update the Service of Official Correspondence...

  4. Non-linear Calibration Leads to Improved Correspondence between Uncertainties

    DEFF Research Database (Denmark)

    Andersen, Jens Enevold Thaulov

    2007-01-01

    limit theorem, an excellent correspondence was obtained between predicted uncertainties and measured uncertainties. In order to validate the method, experiments were applied of flame atomic absorption spectrometry (FAAS) for the analysis of Co and Pt, and experiments of electrothermal atomic absorption...

  5. Correspondence Analysis-Theory and Application in Management Accounting Research

    Science.gov (United States)

    Duller, Christine

    2010-09-01

    Correspondence analysis is an explanatory data analytic technique and is used to identify systematic relations between categorical variables. It is related to principal component analysis and the results provide information on the structure of categorical variables similar to the results given by a principal component analysis in case of metric variables. Classical correspondence analysis is designed two-dimensional, whereas multiple correspondence analysis is an extension to more than two variables. After an introductory overview of the idea and the implementation in standard software packages (PASW, SAS, R) an example in recent research is presented, which deals with strategic management accounting in family and non-family enterprises in Austria, where 70% to 80% of all enterprises can be classified as family firms. Although there is a growing body of literature focusing on various management issues in family firms, so far the state of the art of strategic management accounting in family firms is an empirically under-researched subject. In relevant literature only the (empirically untested) hypothesis can be found, that family firms tend to have less formalized management accounting systems than non-family enterprises. Creating a correspondence analysis will help to identify the underlying structure, which is responsible for differences in strategic management accounting.

  6. A Foreign Correspondent's View of the Electoral Process.

    Science.gov (United States)

    Gardner, Mary A. Ed.

    According to their personal points of view regarding United States politics, a panel of foreign correspondents from other nations evaluated the United States electoral process and discussed the difficulties involved in conveying the complexities of this process to an audience. This document contains an edited transcript of the panel's comments.…

  7. Shape Modelling Using Markov Random Field Restoration of Point Correspondences

    DEFF Research Database (Denmark)

    Paulsen, Rasmus Reinhold; Hilger, Klaus Baggesen

    2003-01-01

    A method for building statistical point distribution models is proposed. The novelty in this paper is the adaption of Markov random field regularization of the correspondence field over the set of shapes. The new approach leads to a generative model that produces highly homogeneous polygonized sh...

  8. The Correspondence of René Descartes: 1643

    NARCIS (Netherlands)

    Verbeek, T.; Bos, E.-J. (Erik-Jan); Ven, Jeroen van de

    2003-01-01

    There is little disagreement that the standard edition of Descartes by Charles Adam and Paul Tannery (1897-1913, known as AT) should be redone, in any case as far as the correspondence is concerned. The reason is not only that its chronology is defective and that in its latest reprint the

  9. Virtual Foreign Correspondence: Experimental Instructions in Digital Foreign News Reporting

    Science.gov (United States)

    Hahn, Oliver; Stalph, Florian; Steller, Tom

    2018-01-01

    Within a series of six qualitative studies over seven years, this research in instructing journalism students investigates whether or not covering foreign news from home via Internet technology can substitute foreign correspondents on-site to reduce costs. Co-orientation and decontextualization can be described as characteristic for virtual…

  10. Planning using dynamic epistemic logic: Correspondence and complexity

    DEFF Research Database (Denmark)

    Jensen, Martin Holm

    2013-01-01

    A growing community investigates planning using dynamic epistemic logic. Another framework based on similar ideas is knowledge-based programs as plans. Here we show how actions correspond in the two frameworks. We finally discuss fragments of DEL planning obtained by the restriction of event models...

  11. Galois Corings and a Jacobson-Bourbaki type Correspondence

    OpenAIRE

    Cuadra, J.; Gomez-Torrecillas, J.

    2005-01-01

    The Jacobson-Bourbaki Theorem for division rings was formulated in terms of corings by Sweedler in 1975. Finiteness conditions hypotheses are not required in this new approach. In this paper we extend Sweedler's result to simple artinian rings using a particular class of corings, comatrix corings. A Jacobson-Bourbaki like correspondence for simple artinian rings is then obtained by duality.

  12. mckay correspondence in quasi-sl quasitoric orbifolds

    Indian Academy of Sciences (India)

    57

    works with M.Poddar we proved the correspondence in dimensions four and six. Here we deal with the general ... Global versions were formulated later as .... Construction. Fix a copy N ... Define an equivalence relation ∼ on the space P × TN by. (2.2) ...... The following has been taken from the paper of Batyrev and. Dais [3].

  13. Deformation theory and local-global compatibility of Langlands correspondences

    CERN Document Server

    Luu, Martin

    2015-01-01

    The deformation theory of automorphic representations is used to study local properties of Galois representations associated to automorphic representations of general linear groups and symplectic groups. In some cases this allows to identify the local Galois representations with representations predicted by a local Langlands correspondence.

  14. Writing through Bureaucracy: Migrant Correspondence and Managed Mobility

    Science.gov (United States)

    Leonard, Rebecca Lorimer

    2015-01-01

    Contemporary international migration produces a great deal of bureaucratic writing activity. This article reports on a study of one bureaucratic literacy practice--correspondence--of 25 international migrants in the United States. Contextual and practice-based analysis of data collected through literacy history interviews shows that (a) by virtue…

  15. Finite Difference Schemes as Algebraic Correspondences between Layers

    Science.gov (United States)

    Malykh, Mikhail; Sevastianov, Leonid

    2018-02-01

    For some differential equations, especially for Riccati equation, new finite difference schemes are suggested. These schemes define protective correspondences between the layers. Calculation using these schemes can be extended to the area beyond movable singularities of exact solution without any error accumulation.

  16. Open-closed string correspondence in open string field theory

    International Nuclear Information System (INIS)

    Baumgartl, M.; Sachs, I.

    2008-01-01

    We address the problem of describing different closed string backgrounds in background independent open string field theory: A shift in the closed string background corresponds to a collective excitation of open strings. As an illustration we apply the formalism to the case where the closed string background is a group manifold. (Abstract Copyright [2008], Wiley Periodicals, Inc.)

  17. The uses and abuses of the coherence – correspondence distinction

    Science.gov (United States)

    Polonioli, Andrea

    2015-01-01

    Kenneth Hammond introduced a distinction between coherence and correspondence criteria of rationality as a tool in the study of judgment and decision-making. This distinction has been widely used in the field. Yet, as this paper seeks to show, the relevant notions of coherence and correspondence have been progressively considered to be too narrow and have undergone non-trivial conceptual changes since their original introduction. I try to show, first, that the proliferation of conceptualizations of coherence and correspondence has created confusion in the literature and that appealing to such notions has not helped to elucidate discussions over the nature of rational judgment and decision-making. Nevertheless, I also argue for a reframing of the debate. In fact, what seems to underlie several contemporary appeals to the notions of coherence and correspondence is best explained in terms of a contrast between what I call rule-based and goal-based rationality. Whilst these categories do need further refinement, they do seem to be useful for organizing and understanding research on rational judgment and decision-making. PMID:25983700

  18. 21 CFR 10.65 - Meetings and correspondence.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Meetings and correspondence. 10.65 Section 10.65 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... religion. (e) An official transcript, recording, or memorandum summarizing the substance of any meeting...

  19. 38 CFR 21.4279 - Combination correspondence-residence program.

    Science.gov (United States)

    2010-07-01

    ... VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Administration of Educational.... (a) Requirements for pursuit. A program of education may be pursued partly in residence and partly by correspondence for the attainment of a predetermined and identified objective under the following conditions: (1...

  20. Fourth Order Nonlinear Intensity and the corresponding Refractive ...

    African Journals Online (AJOL)

    Nonlinear effects occur whenever the optical fields associated with one or more intense light such as from laser beams propagating in a crystal are large enough to produce polarization fields. This paper describes how the fourth order nonlinear intensity and the corresponding effective refractive index that is intensity ...

  1. The Relationship between British War Correspondents in the Field ...

    African Journals Online (AJOL)

    In particular, the article looks at the problem and issues relating to the relationship: licensing correspondents, censorship, monitoring journalists' activities, as well as the successful attempt of the intelligence sector to bring the press into their campaign to spread pro-British propaganda. The role of the press in the saga of the ...

  2. 37 CFR 7.4 - Receipt of correspondence.

    Science.gov (United States)

    2010-07-01

    ... CONCERNING THE INTERNATIONAL REGISTRATION OF MARKS General Information § 7.4 Receipt of correspondence. (a... accorded the date of deposit with the United States Postal Service. (2) Responses to notices of....4 Section 7.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE...

  3. AdS/CFT correspondence in the Euclidean context

    International Nuclear Information System (INIS)

    Gottschalk, H.; Thaler, H.

    2007-01-01

    We study two possible prescriptions for AdS/CFT correspondence by means of functional integrals. The considerations are non-perturbative and reveal certain divergencies which turn out to be harmless, in the sense that reflection-positivity and conformal invariance are not destroyed. (orig.)

  4. ICTs for Microcredit Delivery : Correspondent Banking in Brazil ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Although microfinance has proved a powerful tool in fighting poverty in developing countries, it has been slow to catch on in Latin America, particularly Brazil. On the other hand, correspondent banking enabled by information and communication technologies (ICTs) has allowed Brazil to reach low-income families in remote ...

  5. Generation of a statistical shape model with probabilistic point correspondences and the expectation maximization- iterative closest point algorithm

    International Nuclear Information System (INIS)

    Hufnagel, Heike; Pennec, Xavier; Ayache, Nicholas; Ehrhardt, Jan; Handels, Heinz

    2008-01-01

    Identification of point correspondences between shapes is required for statistical analysis of organ shapes differences. Since manual identification of landmarks is not a feasible option in 3D, several methods were developed to automatically find one-to-one correspondences on shape surfaces. For unstructured point sets, however, one-to-one correspondences do not exist but correspondence probabilities can be determined. A method was developed to compute a statistical shape model based on shapes which are represented by unstructured point sets with arbitrary point numbers. A fundamental problem when computing statistical shape models is the determination of correspondences between the points of the shape observations of the training data set. In the absence of landmarks, exact correspondences can only be determined between continuous surfaces, not between unstructured point sets. To overcome this problem, we introduce correspondence probabilities instead of exact correspondences. The correspondence probabilities are found by aligning the observation shapes with the affine expectation maximization-iterative closest points (EM-ICP) registration algorithm. In a second step, the correspondence probabilities are used as input to compute a mean shape (represented once again by an unstructured point set). Both steps are unified in a single optimization criterion which depe nds on the two parameters 'registration transformation' and 'mean shape'. In a last step, a variability model which best represents the variability in the training data set is computed. Experiments on synthetic data sets and in vivo brain structure data sets (MRI) are then designed to evaluate the performance of our algorithm. The new method was applied to brain MRI data sets, and the estimated point correspondences were compared to a statistical shape model built on exact correspondences. Based on established measures of ''generalization ability'' and ''specificity'', the estimates were very satisfactory

  6. Training management

    International Nuclear Information System (INIS)

    Martin, H.D.

    1986-01-01

    The following topics to be covered in this report are: Design principles for training programmes; training methods, materials and facilities; national and international organization; training assessment and documentation; relation between supplier and customer, licensing requirements and practices. (orig.)

  7. Language Training: English Training

    CERN Document Server

    Françoise Benz

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in...

  8. The Chomsky-Place correspondence 1993-1994.

    Science.gov (United States)

    Chomsky, N; Place, U T

    2000-01-01

    Edited correspondence between Ullin T. Place and Noam Chomsky, which occurred in 1993-1994, is presented. The principal topics are (a) deep versus surface structure; (b) computer modeling of the brain; (c) the evolutionary origins of language; (d) behaviorism; and (e) a dispositional account of language. This correspondence includes Chomsky's denial that he ever characterized deep structure as innate; Chomsky's critique of computer modeling (both traditional and connectionist) of the brain; Place's critique of Chomsky's alleged failure to provide an adequate account of the evolutionary origins of language, and Chomsky's response that such accounts are "pop-Darwinian fairy tales"; and Place's arguments for, and Chomsky's against, the relevance of behaviorism to linguistic theory, especially the relevance of a behavioral approach to language that is buttressed by a dispositional account of sentence construction.

  9. The Chomsky—Place correspondence 1993–1994

    Science.gov (United States)

    Chomsky, Noam; Place, Ullin T.

    2000-01-01

    Edited correspondence between Ullin T. Place and Noam Chomsky, which occurred in 1993–1994, is presented. The principal topics are (a) deep versus surface structure; (b) computer modeling of the brain; (c) the evolutionary origins of language; (d) behaviorism; and (e) a dispositional account of language. This correspondence includes Chomsky's denial that he ever characterized deep structure as innate; Chomsky's critique of computer modeling (both traditional and connectionist) of the brain; Place's critique of Chomsky's alleged failure to provide an adequate account of the evolutionary origins of language, and Chomsky's response that such accounts are “pop-Darwinian fairy tales”; and Place's arguments for, and Chomsky's against, the relevance of behaviorism to linguistic theory, especially the relevance of a behavioral approach to language that is buttressed by a dispositional account of sentence construction. PMID:22477211

  10. On Perturbation Components Correspondence between Diffusion and Transport

    Energy Technology Data Exchange (ETDEWEB)

    G. Palmiotti

    2012-11-01

    We have established a correspondence between perturbation components in diffusion and transport theory. In particular we have established the correspondence between the leakage perturbation component of the diffusion theory to that of the group self scattering in transport theory. This has been confirmed by practical applications on sodium void reactivity calculations of fast reactors. Why this is important for current investigations? Recently, there has been a renewed interest in designing fast reactors where the sodium void reactivity coefficient is minimized. In particular the ASTRID8,9 reactor concept has been optimized with this goal in mind. The correspondence on the leakage term that has been established here has a twofold implication for the design of this kind of reactors. First, this type of reactor has a radial reflector; therefore, as shown before, the sodium void reactivity coefficient calculation requires the use of transport theory. The minimization of the sodium reactivity coefficient is normally done by increasing the leakage component that has a negative sign. The correspondence established in this paper allows to directly look at this component in transport theory. The second implication is related to the uncertainty evaluation on sodium void reactivity. As it has shown before, the total sodium void reactivity effect is the result of a large compensation (opposite sign) between the scattering (called often spectral) component and the leakage one. Consequently, one has to evaluate separately the uncertainty on each separate component and then combine them statistically. If one wants to compute the cross section sensitivity coefficients of the two different components, the formulation established in this paper allows to achieve this goal by playing on the contribution to the sodium void reactivity coming from the group self scattering of the sodium cross section.

  11. Engineering a bosonic AdS/CFT correspondence

    OpenAIRE

    Ketov, Sergei V.; Leonhardt, Thorsten; Rühl, Werner

    2001-01-01

    We search for a possible bosonic (i.e. non-supersymmetric) string/gauge theory correspondence by using IIB and 0B strings as a guide. Our construction is based on the low-energy bosonic string effective action modified by an extra form flux. The closed string tachyon can be stabilyzed if the AdS scale L does not exceed certain critical value, L

  12. Fluid/Gravity Correspondence, Second Order Transport and Gravitational Anomaly*,**

    Directory of Open Access Journals (Sweden)

    Megías Eugenio

    2014-03-01

    Full Text Available We study the transport properties of a relativistic fluid affected by chiral and gauge-gravitational anomalies. The computation is performed in the framework of the fluid/gravity correspondence for a 5 dim holographic model with Chern-Simons terms in the action. We find new anomalous and non anomalous transport coefficients, as well as new contributions to the existing ones coming from the mixed gauge-gravitational anomaly. Consequences for the shear waves dispersion relation are analyzed.

  13. Establishing correspondence in wood: the challenge and some solutions?

    Science.gov (United States)

    Courtin, Gerard M; Fairgrieve, Scott I

    2013-09-01

    Establishing correspondence between the upper portion of a white birch sapling, a suspected weapon, and a potential source from a stand of trees was posed to one of us (GMC). A bending force shattered the sapling, precluding physical matching. Three white birch saplings were taken from the same stand of trees in a similar manner. Correspondence was achieved by measuring the width of the annual rings along four radii from a disk cut above and below the break. The regression coefficient of the data from the two disks from the same sapling was r(2) = 0.95. Regressing the upper disk against the lower disk of two other saplings resulted in r(2) values of 0.26 and 0.17, respectively. The various characteristics that are confined to a wood stem as part of its normal process of growth can be used to eliminate candidate saplings and establish correspondence between two pieces of wood. © 2013 American Academy of Forensic Sciences.

  14. Integrability and the AdS/CFT correspondence

    International Nuclear Information System (INIS)

    Serban, Didina

    2011-01-01

    The description of gauge theories at strong coupling is one of the long-standing problems in theoretical physics. The idea of a relation between strongly coupled gauge theories and string theory was pioneered by 't Hooft, Wilson and Polyakov. A decade ago, Maldacena made this relation explicit by conjecturing the exact equivalence of a conformally invariant theory in four dimensions, the maximally supersymmetric Yang-Mills theory, with string theory in the AdS 5 x S 5 background. Other examples of correspondence between a conformally invariant theory and string theory in an AdS background were discovered recently. The comparison of the two sides of the correspondence requires the use of non-perturbative methods. The discovery of integrable structures in gauge theory and string theory led to the conjecture that the two theories are integrable for any value of the coupling constant and that they share the same integrable structure defined non-perturbatively. The last 8 years brought remarkable progress in identifying this solvable model and in explicitly solving the problem of computing the spectrum of conformal dimensions of the theory. The progress came from the identification of the dilatation operator with an integrable spin chain and from the study of the string sigma model. In this review, I present the evolution of the concept of integrability in the framework of the AdS/CFT correspondence and the main results obtained using this approach. (review)

  15. Quantum-classical correspondence for the inverted oscillator

    Science.gov (United States)

    Maamache, Mustapha; Ryeol Choi, Jeong

    2017-11-01

    While quantum-classical correspondence for a system is a very fundamental problem in modern physics, the understanding of its mechanism is often elusive, so the methods used and the results of detailed theoretical analysis have been accompanied by active debate. In this study, the differences and similarities between quantum and classical behavior for an inverted oscillator have been analyzed based on the description of a complete generalized Airy function-type quantum wave solution. The inverted oscillator model plays an important role in several branches of cosmology and particle physics. The quantum wave packet of the system is composed of many sub-packets that are localized at different positions with regular intervals between them. It is shown from illustrations of the probability density that, although the quantum trajectory of the wave propagation is somewhat different from the corresponding classical one, the difference becomes relatively small when the classical excitation is sufficiently high. We have confirmed that a quantum wave packet moving along a positive or negative direction accelerates over time like a classical wave. From these main interpretations and others in the text, we conclude that our theory exquisitely illustrates quantum and classical correspondence for the system, which is a crucial concept in quantum mechanics. Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1A09919503)

  16. The Lyttleton-Hoyle correspondence 1939-42

    Science.gov (United States)

    Mitton, S.

    2005-12-01

    Fred Hoyle started to collaborate with his older colleague Raymond Lyttleton in 1938. Hoyle's doctoral research had been in nuclear physics, and his supervisors were Rudolph Peierls and Paul Dirac. His first papers were in quantum electrodynamics. When Hoyle decided to change his research field to astronomy, Lyttleton acted as a mentor, and it was he who suggested that Hoyle should look at the physics of accretion. From late-1939, Lyttleton and Hoyle were both scientific civil servants drafted in for war work. They were in different establishments and could communicate only by the postal service. Some 70 letters from Lyttleton to Hoyle have survived, but we do not have any copies of Hoyle's correspondence. Many letters are undated, so it required detective work to assemble them in the correct sequence. The correspondence shows that Lyttleton played the senior role in determining what problems they should tackle, and in what order. Apart from the scientific content, these letters are remarkable for the sharp personal remarks Lyttleton makes of other colleagues, and particularly the Council of the Royal Astronomical Society. I make the suggestion that the poisonous and prolonged nature of the correspondence considerably influenced Hoyle's subsequent attitude to the establishment, to government-employed astronomers, and to the RAS. This was detrimental when Hoyle found, later in his career, that he would have to provide answers to these stakeholders. This research has been supported by St Edmund's College, Cambridge, UK.

  17. Modified Van der Waals equation and law of corresponding states

    Science.gov (United States)

    Zhong, Wei; Xiao, Changming; Zhu, Yongkai

    2017-04-01

    It is well known that the Van der Waals equation is a modification of the ideal gas law, yet it can be used to describe both gas and liquid, and some important messages can be obtained from this state equation. However, the Van der Waals equation is not a precise state equation, and it does not give a good description of the law of corresponding states. In this paper, we expand the Van der Waals equation into its Taylor's series form, and then modify the fourth order expansion by changing the constant Virial coefficients into their analogous ones. Via this way, a more precise result about the law of corresponding states has been obtained, and the law of corresponding states can then be expressed as: in terms of the reduced variables, all fluids should obey the same equation with the analogous Virial coefficients. In addition, the system of 3 He with quantum effects has also been taken into consideration with our modified Van der Waals equation, and it is found that, for a normal system without quantum effect, the modification on ideal gas law from the Van der Waals equation is more significant than the real case, however, for a system with quantum effect, this modification is less significant than the real case, thus a factor is introduced in this paper to weaken or strengthen the modification of the Van der Waals equation, respectively.

  18. Spatial Congruity Effects Reveal Metaphorical Thinking, not Polarity Correspondence.

    Science.gov (United States)

    Dolscheid, Sarah; Casasanto, Daniel

    2015-01-01

    Spatial congruity effects have often been interpreted as evidence for metaphorical thinking, but an alternative account based on polarity correspondence (a.k.a. markedness) has challenged this view. Here we compared metaphor- and polarity-correspondence-based explanations for spatial congruity effects, using musical pitch as a testbed. In one experiment, English speakers classified high- and low-frequency pitches as "high" and "low," or as "front" and "back," to determine whether space-pitch congruity effects could be elicited by any marked spatial continuum. Although both pairs of terms describe bipolar spatial continuums, we found congruity effects only for high/low judgments, indicating that markedness is not sufficient to produce space-pitch congruity effects. A second experiment confirmed that there were no space-pitch congruity effects for another pair of terms that have clear markedness (big/small), but which do not denote spatial height. By contrast, this experiment showed congruity effects for words that cued an appropriate vertical spatial schema (tall/short), even though these words are not used conventionally in English to describe pitches, ruling out explanations for the observed pattern of results based on verbal polysemy. Together, results suggest that space-pitch congruity effects reveal metaphorical uses of spatial schemas, not polarity correspondence effects.

  19. Spatial congruity effects reveal metaphorical thinking, not polarity correspondence

    Directory of Open Access Journals (Sweden)

    Sarah eDolscheid

    2015-11-01

    Full Text Available Spatial congruity effects have often been interpreted as evidence for metaphorical thinking, but an alternative account based on polarity correspondence (a.k.a. markedness has challenged this view. Here we compared metaphor- and polarity-correspondence-based explanations for spatial congruity effects, using musical pitch as a testbed. In one experiment, English speakers classified high- and low-frequency pitches as high and low, or as front and back, to determine whether space-pitch congruity effects could be elicited by any marked spatial continuum. Although both pairs of terms describe bipolar spatial continuums, we found congruity effects only for high/low judgments, indicating that markedness is not sufficient to produce space-pitch congruity effects. A second experiment confirmed that there were no space-pitch congruity effects for another pair of terms that have clear markedness (big/small, but which do not denote spatial height. By contrast, this experiment showed congruity effects for words that cued an appropriate vertical spatial schema (tall/short, even though these words are not used conventionally in English to describe pitches, ruling out explanations for the observed pattern of results based on verbal polysemy. Together, results suggest that space-pitch congruity effects reveal metaphorical uses of spatial schemas, not polarity correspondence effects.

  20. Quantum-Classical Correspondence Principle for Work Distributions

    Directory of Open Access Journals (Sweden)

    Christopher Jarzynski

    2015-09-01

    Full Text Available For closed quantum systems driven away from equilibrium, work is often defined in terms of projective measurements of initial and final energies. This definition leads to statistical distributions of work that satisfy nonequilibrium work and fluctuation relations. While this two-point measurement definition of quantum work can be justified heuristically by appeal to the first law of thermodynamics, its relationship to the classical definition of work has not been carefully examined. In this paper, we employ semiclassical methods, combined with numerical simulations of a driven quartic oscillator, to study the correspondence between classical and quantal definitions of work in systems with 1 degree of freedom. We find that a semiclassical work distribution, built from classical trajectories that connect the initial and final energies, provides an excellent approximation to the quantum work distribution when the trajectories are assigned suitable phases and are allowed to interfere. Neglecting the interferences between trajectories reduces the distribution to that of the corresponding classical process. Hence, in the semiclassical limit, the quantum work distribution converges to the classical distribution, decorated by a quantum interference pattern. We also derive the form of the quantum work distribution at the boundary between classically allowed and forbidden regions, where this distribution tunnels into the forbidden region. Our results clarify how the correspondence principle applies in the context of quantum and classical work distributions and contribute to the understanding of work and nonequilibrium work relations in the quantum regime.

  1. Main principles of development stationary training facilities

    International Nuclear Information System (INIS)

    Tsiptsyura, R.D.

    1986-01-01

    The designation of stationary training facilities is shown and the main requirements for them are formulated. When considering the above-mentioned requirements, special attention was paid to obligatory correspondence between training experience and practical skill of an operator. It is shown, that the switchboard block is the major unit of the training facility, which should develop skills and habits of an operator

  2. Declarative terrain modeling for military training games

    NARCIS (Netherlands)

    Smelik, R.M.; Tutenel, T.; Kraker, J.K.. de; Bidarra, R.

    2010-01-01

    Military training instructors increasingly often employ computer games to train soldiers in all sorts of skills and tactics. One of the difficulties instructors face when using games as a training tool is the creation of suitable content, including scenarios, entities, and corresponding terrain

  3. Upgraded operator training by using advanced simulators

    International Nuclear Information System (INIS)

    Iwashita, Akira; Toeda, Susumu; Fujita, Eimitsu; Moriguchi, Iwao; Wada, Kouji

    1991-01-01

    BWR Operator Training Center Corporation (BTC) has been conducting the operator training for all BWR utilities in Japan using fullscope simulators. Corresponding to increasing quantitative demands and higher qualitative needs of operator training, BTC put advanced simulators in operation (BTC-2 simulator in 1983 and BTC-3 simulator in 1989). This paper describes the methods and the effects of upgraded training contents by using these advanced simulators. These training methods are applied to the 'Advanced Operator Training course,' the 'Operator Retraining Course' and also the 'Family (crew) Training Course.' (author)

  4. Monju operator training report. Training results and upgrade of the operation training simulator in 2002 YF

    International Nuclear Information System (INIS)

    Koyagoshi, Naoki; Sasaki, Kazuichi; Sawada, Makoto; Kawanishi, Tomotake; Yoshida, Kazuo

    2003-09-01

    The prototype fast breeder reactor, Monju, has been performing deliberately the operator training which is composed of the regulated training required by the government and the self-training. The training used a full scope type simulator (MARS: Monju Advanced Reactor Simulator) plays an important role among of the above mentioned trainings and greatly contributes to the Monju operator training for Monju restarting. This report covers the activities of Monju operator training in 2002 FY, i.e. the training results and the remodeling working of the MARS in progress since 1999. (1) Eight simulator training courses were carried out 46 times and 180 trainees participated. Additionally, both the regulated training and self-training were held total 10 times by attended 34 trainees, as besides simulator training. (2) Above training data was reduced compare with the last year's data (69 times (338 trainees)) due to the indispensable training courses in Monju operator training were changed by reorganized operator's number and decreasing of training times owing to remodeling working of the simulator was conducted. (3) By means of upgrading of the MARS completed in 2002 FY, its logic arithmetic time was became speedier and its instructing function was improved remarkably, thus, the simulator training was became to be more effective. Moreover, it's planning to do both remodeling in the next year as the final working: remodeling of reactor core model with the aim of improvement simulating accuracy and corresponding to the sodium leakage measures. Regarding on the Monju training results and simulator's remodeling so far finished, please referring JNC report number of JNC TN 4410 2002-001 Translation of Monju Simulator Training owing Monju Accident and Upgrade of MARS''. (author)

  5. Development of the State Correspondence Language of the Crimean Khanate

    Directory of Open Access Journals (Sweden)

    R.R. Abduzhemilev

    2016-12-01

    Full Text Available Objectvie and materials of the research: In the article the matter for consideration is the problem of the lingual basis in yarlyks of the Crimean Khanate. The author seeks to trace the process of the formation of the state language of the Crimean Khanate on the material of the official letters and decrees. The main statements characterizing the object of the study are formulated. The article presents the views of the famous orientalists, in which the structure of the yarlyk’s language is reflected. An important attention is focused on the ration of the Kipchak and Oguz elements. The period from the 13th century to the 16th century is marked by the development of the language called «desht tili», i.e. the language of Desht-i Kipchak. Results and novelty of the research: The author emphasizes that the language of the yarlyks of the Crimean Khanate is a heritage of the literary language of the Jochid ulus (Golden Horde, and even earlier one – of Desht-i Kipchak. Kipchaks dominated the extremely vast territory. The Kipchak language for a long time was used in the correspondence between Bakhchisaray and Moscow. As for the correspondence between Bakhchisaray and Istanbul, instead of Kipchak there was used Ottoman language. The correspondence between Crimea and Poland was mixed: both Kipchak and Ottoman languages were in use. Concerning the lexical structure of yarlyks, there are many Arabic and Persian words and forms which became inseparable part of the Crimean Tatar language. While the texts of the early yarlyks are full mostly of Turkic words, then in the late yarlyks Arabic and Persian words in some cases displaced original Turkic words. Therefore, today the issue of the reconstruction of the Turkic basis is of high importance. The language of the official correspondence from the Crimean Khanate’s Office is one of the indicators of the development of integral state formation on the map of the Eastern Europe. On the one hand, the language

  6. Hematological toxicity in radioimmunotherapy is predicted both by the computed absorbed whole body dose (cGy) and by the administered dose (mCi)

    International Nuclear Information System (INIS)

    Marquez, Sheri D.; Knox, Susan J.; Trisler, Kirk D.; Goris, Michael L.

    1997-01-01

    Purpose/Objective: Radioimmunotherapy (RIT) has yielded encouraging response rates in patients with recurrent non-Hodgkin's lymphoma, but myelotoxicity remains the dose limiting factor. Dose optimization is theoretically possible, since a pretreatment biodistribution study with tracer doses allows for a fairly accurate estimate of the whole body (and by implication the bone marrow) dose in patients. It has been shown that the radiation dose as a function of the administered dose varies widely from patient to patient. The pretreatment study could therefore be used to determine the maximum tolerable dose for each individual patient. The purpose of this study was to examine whether the administered dose or the estimated whole body absorbed radiation dose were indeed predictors of bone marrow toxicity. Materials and Methods: We studied two cohorts of patients to determine if the computed integral whole body or marrow dose is predictive of myelotoxicity. The first cohort consisted of 13 patients treated with Yttrium-90 labeled anti-CD20 (2B8) monoclonal antibody. Those patients were treated in a dose escalation protocol, based on the administered dose, without correction for weight or body surface. The computed whole body dose varied from 41 to 129 cGy. The second cohort (6 patients) were treated with Iodine-131 labeled anti-CD20 (B1) antibody. In this group the administered dose was tailored to deliver an estimated 75 cGy whole body dose. The administered dose varied from 54 to 84 mCi of Iodine-131. For each patient, white blood cell count with differential, hemoglobin, hematocrit, and platelet levels were measured before and at regular intervals after RIT was administered. Using linear regression analysis, a relationship between administered dose, absorbed dose and myelotoxicity was determined for each patient cohort. Results: Marrow toxicity was measured by the absolute decrease in white blood cell (DWBC), platelet (DPLAT), and neutrophil (DN) values. In the Yttrium

  7. Teacher candidates' mastery of phoneme-grapheme correspondence: massed versus distributed practice in teacher education.

    Science.gov (United States)

    Sayeski, Kristin L; Earle, Gentry A; Eslinger, R Paige; Whitenton, Jessy N

    2017-04-01

    Matching phonemes (speech sounds) to graphemes (letters and letter combinations) is an important aspect of decoding (translating print to speech) and encoding (translating speech to print). Yet, many teacher candidates do not receive explicit training in phoneme-grapheme correspondence. Difficulty with accurate phoneme production and/or lack of understanding of sound-symbol correspondence can make it challenging for teachers to (a) identify student errors on common assessments and (b) serve as a model for students when teaching beginning reading or providing remedial reading instruction. For students with dyslexia, lack of teacher proficiency in this area is particularly problematic. This study examined differences between two learning conditions (massed and distributed practice) on teacher candidates' development of phoneme-grapheme correspondence knowledge and skills. An experimental, pretest-posttest-delayed test design was employed with teacher candidates (n = 52) to compare a massed practice condition (one, 60-min session) to a distributed practice condition (four, 15-min sessions distributed over 4 weeks) for learning phonemes associated with letters and letter combinations. Participants in the distributed practice condition significantly outperformed participants in the massed practice condition on their ability to correctly produce phonemes associated with different letters and letter combinations. Implications for teacher preparation are discussed.

  8. Automated corresponding point candidate selection for image registration using wavelet transformation neurla network with rotation invariant inputs and context information about neighboring candidates

    Science.gov (United States)

    Okumura, Hiroshi; Suezaki, Masashi; Sueyasu, Hideki; Arai, Kohei

    2003-03-01

    An automated method that can select corresponding point candidates is developed. This method has the following three features: 1) employment of the RIN-net for corresponding point candidate selection; 2) employment of multi resolution analysis with Haar wavelet transformation for improvement of selection accuracy and noise tolerance; 3) employment of context information about corresponding point candidates for screening of selected candidates. Here, the 'RIN-net' means the back-propagation trained feed-forward 3-layer artificial neural network that feeds rotation invariants as input data. In our system, pseudo Zernike moments are employed as the rotation invariants. The RIN-net has N x N pixels field of view (FOV). Some experiments are conducted to evaluate corresponding point candidate selection capability of the proposed method by using various kinds of remotely sensed images. The experimental results show the proposed method achieves fewer training patterns, less training time, and higher selection accuracy than conventional method.

  9. Language Training - French Training

    CERN Multimedia

    HR Department

    2008-01-01

    General and Professional French Courses The next session will take place from 26 January to 3rd April 2009. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Writing Professional Documents in French The next session will take place from 26 January to 3rd April 2009. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF For further information and registration, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Nathalie Dumeaux Tel. 78144 mailto:nathalie.dumeaux@cern.ch

  10. Language Training - French Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional French Courses The next session will take place from 26 January to 3rd April 2009. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Writing Professional Documents in French The next session will take place from 26 January to 3rd April 2009. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF For further information and registration, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Nathalie Dumeaux Tel. 78144 mailto:nathalie.dumeaux@cern.ch

  11. Training organisation

    International Nuclear Information System (INIS)

    Andrlova, Z.

    2012-01-01

    Slovenske elektrarne considers a specific training and education of experienced experts to be a key issue. The company gradually undergoes quite demanding change in the field of education and training of the nuclear power plants staff. We have an ambitious vision - to create one of the best training organisations in Europe by the means of systematic approach to the training. (author)

  12. Finding Chemical Structures Corresponding to a Set of Coordinates in Chemical Descriptor Space.

    Science.gov (United States)

    Miyao, Tomoyuki; Funatsu, Kimito

    2017-08-01

    When chemical structures are searched based on descriptor values, or descriptors are interpreted based on values, it is important that corresponding chemical structures actually exist. In order to consider the existence of chemical structures located in a specific region in the chemical space, we propose to search them inside training data domains (TDDs), which are dense areas of a training dataset in the chemical space. We investigated TDDs' features using diverse and local datasets, assuming that GDB11 is the chemical universe. These two analyses showed that considering TDDs gives higher chance of finding chemical structures than a random search-based method, and that novel chemical structures actually exist inside TDDs. In addition to those findings, we tested the hypothesis that chemical structures were distributed on the limited areas of chemical space. This hypothesis was confirmed by the fact that distances among chemical structures in several descriptor spaces were much shorter than those among randomly generated coordinates in the training data range. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Audiovisual correspondence between musical timbre and visual shapes.

    Directory of Open Access Journals (Sweden)

    Mohammad eAdeli

    2014-05-01

    Full Text Available This article investigates the cross-modal correspondences between musical timbre and shapes. Previously, such features as pitch, loudness, light intensity, visual size, and color characteristics have mostly been used in studies of audio-visual correspondences. Moreover, in most studies, simple stimuli e.g. simple tones have been utilized. In this experiment, 23 musical sounds varying in fundamental frequency and timbre but fixed in loudness were used. Each sound was presented once against colored shapes and once against grayscale shapes. Subjects had to select the visual equivalent of a given sound i.e. its shape, color (or grayscale and vertical position. This scenario permitted studying the associations between normalized timbre and visual shapes as well as some of the previous findings for more complex stimuli. 119 subjects (31 females and 88 males participated in the online experiment. Subjects included 36 claimed professional musicians, 47 claimed amateur musicians and 36 claimed non-musicians. 31 subjects have also claimed to have synesthesia-like experiences. A strong association between timbre of envelope normalized sounds and visual shapes was observed. Subjects have strongly associated soft timbres with blue, green or light gray rounded shapes, harsh timbres with red, yellow or dark gray sharp angular shapes and timbres having elements of softness and harshness together with a mixture of the two previous shapes. Color or grayscale had no effect on timbre-shape associations. Fundamental frequency was not associated with height, grayscale or color. The significant correspondence between timbre and shape revealed by the present work allows designing substitution systems which might help the blind to perceive shapes through timbre.

  14. Black holes in the gravity/gauge theory correspondence

    International Nuclear Information System (INIS)

    Gregory, J.P.

    2002-06-01

    The AdS/CFT correspondence provides a microscopic description of black hole thermodynamics. In this thesis, I study the relation between the classical physics of black holes and this microscopic description. I first consider the gauge theory's holographic encoding of non-trivial global causal structure, by studying various probes of the black hole. I study the charged black hole, so that the thermal scale is separated from the horizon scale, to demonstrate which relates to the field theory scale size. I find that, when probing the horizon, both Wilson loops and the duals of static supergravity probes have a scale size determined by the horizon, but the field theory scale size is divergent for a time-dependent probe. I also use the bulk black hole geometry to study the physics of the boundary theory. If we consider a dynamical boundary, a braneworld cosmology is induced from the bulk. However, the presence of matter on the brane introduces unconventional quadratic terms in the FRW equations of this braneworld. I find that bulk black holes induce identical unconventional terms on a matterless brane, therefore providing an alternative description of the same cosmology. A new conjecture relating classical and thermodynamic stability of black branes has emerged from the AdS/CFT correspondence. I make progress in proving this for the case of Schwarzschild black holes in a finite cavity. I also extend the conjecture to the supergravity backgrounds of the direct product form Schwarzschild-AdS x Sphere, which are relevant to my study of the AdS/CFT correspondence. (author)

  15. Unified bulk-boundary correspondence for band insulators

    Science.gov (United States)

    Rhim, Jun-Won; Bardarson, Jens H.; Slager, Robert-Jan

    2018-03-01

    The bulk-boundary correspondence, a topic of intensive research interest over the past decades, is one of the quintessential ideas in the physics of topological quantum matter. Nevertheless, it has not been proven in all generality and has in certain scenarios even been shown to fail, depending on the boundary profiles of the terminated system. Here, we introduce bulk numbers that capture the exact number of in-gap modes, without any such subtleties in one spatial dimension. Similarly, based on these 1D bulk numbers, we define a new 2D winding number, which we call the pole winding number, that specifies the number of robust metallic surface bands in the gap as well as their topological character. The underlying general methodology relies on a simple continuous extrapolation from the bulk to the boundary, while tracking the evolution of Green's function's poles in the vicinity of the bulk band edges. As a main result we find that all the obtained numbers can be applied to the known insulating phases in a unified manner regardless of the specific symmetries. Additionally, from a computational point of view, these numbers can be effectively evaluated without any gauge fixing problems. In particular, we directly apply our bulk-boundary correspondence construction to various systems, including 1D examples without a traditional bulk-boundary correspondence, and predict the existence of boundary modes on various experimentally studied graphene edges, such as open boundaries and grain boundaries. Finally, we sketch the 3D generalization of the pole winding number by in the context of topological insulators.

  16. Alternating multivariate trigonometric functions and corresponding Fourier transforms

    International Nuclear Information System (INIS)

    Klimyk, A U; Patera, J

    2008-01-01

    We define and study multivariate sine and cosine functions, symmetric with respect to the alternating group A n , which is a subgroup of the permutation (symmetric) group S n . These functions are eigenfunctions of the Laplace operator. They determine Fourier-type transforms. There exist three types of such transforms: expansions into corresponding sine-Fourier and cosine-Fourier series, integral sine-Fourier and cosine-Fourier transforms, and multivariate finite sine and cosine transforms. In all these transforms, alternating multivariate sine and cosine functions are used as a kernel

  17. Sir Rudolf Peierls Selected private and scientific correspondence

    CERN Document Server

    Lee, Sabine

    2007-01-01

    This edition of the private and scientific correspondence of Sir Rudolf Peierls gives a unique insight into the life and work of one of the greatest theoretical physicists of the 20th century. Rudolf Peierls' scientific work contributed to the early developments in quantum mechanics, and he is well known and much appreciated for his contributions to various disciplines, including solid state physics, nuclear physics, and particle physics. As an enthusiastic and devoted teacher, he passed on his knowledge and understanding and inspired the work of collaborators and students alike. As an effecti

  18. THE FLEXIBILITY-AUTOMATION CORRESPONDENCE TO A VIRTUAL COMMERCIAL SOCIETY

    Directory of Open Access Journals (Sweden)

    Liliana Doble

    2012-01-01

    Full Text Available Design and operation of FMS is based on system requirement can be as productive and flexible as necessary, i.e. obtaining controlled correspondence between the degree of flexibility and automation of system.The flexibility of a FMS (Flexible Manufacturing Systems is determined by two important criteria: Flexible hardware structure of the system; Flexible software structure. Flexible hardware structure of the CS system (calculation system is determined to its turn according to three components: Flexibility of technological subsystem; Flexibility subsystem of storage, transport and handling;Flexibility of informational subsystem.

  19. D-instantons on orbifolds and gauge/gravity correspondence

    International Nuclear Information System (INIS)

    Tanzini, Alessandro

    2002-01-01

    D-instantons are used to probe the near-horizon geometry of D3-branes systems on orbifold spaces. For fractional D3-branes, D-instanton calculus correctly reproduces the gauge β-function and U(1) R anomaly of the corresponding N=2 non-conformal Super Yang-Mills theories. For D3-branes wrapping the orbifold singularity, D-instantons can be identified with gauge instantons on ALE space, providing evidence of AdS/CFT duality for gauge theories on curved spaces. (Abstract Copyright[2002], Wiley Periodicals, Inc.)

  20. Scaling dimensions in hidden Kerr/CFT correspondence

    International Nuclear Information System (INIS)

    Lowe, David A.; Messamah, Ilies; Skanata, Antun

    2011-01-01

    It has been proposed that a hidden conformal field theory (CFT) governs the dynamics of low frequency scattering in a general Kerr black hole background. We further investigate this correspondence by mapping higher order corrections to the massless wave equations in a Kerr background to an expansion within the CFT in terms of higher dimension operators. This implies the presence of infinite towers of CFT primary operators with positive conformal dimensions compatible with unitarity. The exact Kerr background softly breaks the conformal symmetry and the scaling dimensions of these operators run with frequency. The scale-invariant fixed point is dual to a degenerate case of flat spacetime.

  1. Unraveling mulitple translatorship through an e-mail correspondence

    DEFF Research Database (Denmark)

    Jansen, Hanne

    2017-01-01

    The aim of this study is to shed light on questions of “multiple translatorship” and particularly on translation collaboration processes. The empirical material consists of more than three hundred e-mails exchanged between two co-translators who translated Claudio Magris’s novel Alla cieca (2005......) into Danish. The theoretical framework presents a double perspective through which the e-mail correspondence is studied: on the one hand, as an ethnographic “thick description” (focusing on translation as an event), with the aim of uncovering who the agents involved are, how they interact, and what...

  2. Schwinger-Keldysh propagators from AdS/CFT correspondence

    International Nuclear Information System (INIS)

    Herzog, C.P.; Son, D.T.

    2003-01-01

    We demonstrate how to compute real-time Green's functions for a class of finite temperature field theories from their AdS gravity duals. In particular, we reproduce the two-by-two Schwinger-Keldysh matrix propagator from a gravity calculation. Our methods should work also for computing higher point lorentzian signature correlators. We elucidate the boundary condition subtleties which hampered previous efforts to build a lorentzian-signature AdS/CFT correspondence. For two-point correlators, our construction is automatically equivalent to the previously formulated prescription for the retarded propagator. (author)

  3. Toward the correspondence between Q-clouds and sphalerons

    Energy Technology Data Exchange (ETDEWEB)

    Nugaev, E., E-mail: emin@ms2.inr.ac.ru [Institute for Nuclear Research of the Russian Academy of Sciences, 60th October Anniversary prospect 7a, 117312, Moscow (Russian Federation); Shkerin, A., E-mail: shkerin@inr.ru [Institute for Nuclear Research of the Russian Academy of Sciences, 60th October Anniversary prospect 7a, 117312, Moscow (Russian Federation); École Polytechnique Fédérale de Lausanne, CH-1015, Lausanne (Switzerland)

    2015-07-30

    Non-linear classical equations of motion may admit degenerate solutions at fixed charges. Whereas the solutions with lower energies are classically stable, those with larger energies are unstable and are referred to as Q-clouds. We consider a theory in which a homogeneous charged condensate is classically stable and argue that Q-clouds correspond to sphalerons between the stable Q-balls and the condensate. For a model with an analytical solution, we present the Arrhenius formula for the quantum production of Q-balls from a condensate at high temperatures.

  4. Introduction to the AdS/CFT Correspondence

    Science.gov (United States)

    Nąstase, Horaǧiu

    2015-09-01

    Preface; Introduction; Part I. Background: 1. Elements of quantum field theory and gauge theory; 2. Basics of general relativity. Anti-de Sitter space; 3. Basics of supersymmetry; 4. Basics of supergravity; 5. Kaluza-Klein dimensional reduction; 6. Black holes and p-branes; 7. String theory actions and spectra; 8. Elements of conformal field theory; 9. D-branes; Part II. Basics of AdS/CFT for N = 4 SYM vs AdS5 × S5: 10. The AdS/CFT correspondence: motivation, definition and spectra; 11. Witten prescription and 3-point correlator calculations; 12. Holography in Lorentzian signature: Poincaré and global; 13. Solitonic objects in AdS/CFT; 14. Quarks and the Wilson loop; 15. Finite temperature and N = 4 SYM plasmas; 16. Scattering processes and gravitational shockwave limit; 17. The pp-wave correspondence; 18. Spin chains; Part III. AdS/CFT Developments and Gauge-Gravity Dualities: 19. Other conformal cases; 20. The 3 dimensional ABJM model vs. AdS4 × CP3; 21. Gravity duals; 22. Holographic renormalization; 23. RG flow between fixed points; 24. Phenomenological gauge-gravity duality I: AdS/QCD; 25. Phenomenological gauge-gravity duality II: AdS/CMT; 26. Gluon scattering: the Alday-Maldacena prescription; 27. Holographic entanglement entropy: the Ryu-Takayanagi prescription.

  5. Light-Front Holography and AdS/QCD Correspondence

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, Stanley J.; de Teramond, Guy F.

    2008-04-23

    Light-Front Holography is a remarkable consequence of the correspondence between string theory in AdS space and conformal field theories in physical-space time. It allows string modes {Phi}(z) in the AdS fifth dimension to be precisely mapped to the light-front wavefunctions of hadrons in terms of a specific light-front impact variable {zeta} which measures the separation of the quark and gluonic constituents within the hadron. This mapping was originally obtained by matching the exact expression for electromagnetic current matrix elements in AdS space with the corresponding exact expression for the current matrix element using light-front theory in physical space-time. More recently we have shown that one obtains the identical holographic mapping using matrix elements of the energy-momentum tensor, thus providing an important consistency test and verification of holographic mapping from AdS to physical observables defined on the light-front. The resulting light-front Schrodinger equations predicted from AdS/QCD give a good representation of the observed meson and baryon spectra and give excellent phenomenological predictions for amplitudes such as electromagnetic form factors and decay constants.

  6. Investigating the correspondence between driver head position and glance location

    Directory of Open Access Journals (Sweden)

    Joonbum Lee

    2018-02-01

    Full Text Available The relationship between a driver’s glance orientation and corresponding head rotation is highly complex due to its nonlinear dependence on the individual, task, and driving context. This paper presents expanded analytic detail and findings from an effort that explored the ability of head pose to serve as an estimator for driver gaze by connecting head rotation data with manually coded gaze region data using both a statistical analysis approach and a predictive (i.e., machine learning approach. For the latter, classification accuracy increased as visual angles between two glance locations increased. In other words, the greater the shift in gaze, the higher the accuracy of classification. This is an intuitive but important concept that we make explicit through our analysis. The highest accuracy achieved was 83% using the method of Hidden Markov Models (HMM for the binary gaze classification problem of (a glances to the forward roadway versus (b glances to the center stack. Results suggest that although there are individual differences in head-glance correspondence while driving, classifier models based on head-rotation data may be robust to these differences and therefore can serve as reasonable estimators for glance location. The results suggest that driver head pose can be used as a surrogate for eye gaze in several key conditions including the identification of high-eccentricity glances. Inexpensive driver head pose tracking may be a key element in detection systems developed to mitigate driver distraction and inattention.

  7. Topologically massive gravity and the AdS/CFT correspondence

    International Nuclear Information System (INIS)

    Skenderis, Kostas; Taylor, Marika; Rees, Balt C. van

    2009-01-01

    We set up the AdS/CFT correspondence for topologically massive gravity (TMG) in three dimensions. The first step in this procedure is to determine the appropriate fall off conditions at infinity. These cannot be fixed a priori as they depend on the bulk theory under consideration and are derived by solving asymptotically the non-linear field equations. We discuss in detail the asymptotic structure of the field equations for TMG, showing that it contains leading and subleading logarithms, determine the map between bulk fields and CFT operators, obtain the appropriate counterterms needed for holographic renormalization and compute holographically one- and two-point functions at and away from the 'chiral point' (μ = 1). The 2-point functions at the chiral point are those of a logarithmic CFT (LCFT) with c L = 0,c R = 3l/G N and b = -3l/G N , where b is a parameter characterizing different c = 0 LCFTs. The bulk correlators away from the chiral point (μ ≠ 1) smoothly limit to the LCFT ones as μ → 1. Away from the chiral point, the CFT contains a state of negative norm and the expectation value of the energy momentum tensor in that state is also negative, reflecting a corresponding bulk instability due to negative energy modes.

  8. Aspects of defects in 3d-3d correspondence

    International Nuclear Information System (INIS)

    Gang, Dongmin; Kim, Nakwoo; Romo, Mauricio; Yamazaki, Masahito

    2016-01-01

    In this paper we study supersymmetric co-dimension 2 and 4 defects in the compactification of the 6d (2,0) theory of type A_N_−_1 on a 3-manifold M. The so-called 3d-3d correspondence is a relation between complexified Chern-Simons theory (with gauge group SL(N,ℂ)) on M and a 3d N=2 theory T_N[M]. We study this correspondence in the presence of supersymmetric defects, which are knots/links inside the 3-manifold. Our study employs a number of different methods: state-integral models for complex Chern-Simons theory, cluster algebra techniques, domain wall theory T[SU(N)], 5d N=2 SYM, and also supergravity analysis through holography. These methods are complementary and we find agreement between them. In some cases the results lead to highly non-trivial predictions on the partition function. Our discussion includes a general expression for the cluster partition function, which can be used to compute in the presence of maximal and certain class of non-maximal punctures when N>2. We also highlight the non-Abelian description of the 3d N=2T_N[M] theory with defect included, when such a description is available. This paper is a companion to our shorter paper http://dx.doi.org/10.1088/1751-8113/49/30/30LT02, which summarizes our main results.

  9. Fundamental quark, lepton correspondence and dynamics with weak decay interactions

    International Nuclear Information System (INIS)

    Van der Spuy, E.

    1977-10-01

    A nonlinear fermion-field equation of motion and its (in principle) exact solutions, making use of the previously developed technique of infinite component free spinor fields, are discussed. It is shown to be essential for the existence of the solutions to introduce the isosymmetry breaking mechanism by coupling the isospin polarization of the domain of the universe of such particle fields to the field isospin. The essential trigger for the isosymmetry breaking mechanism is the existence of the electromagnetic interaction and the photon fields, carrying an infinite range isospin polarization change in the domain. A quartet of proton, neutron, lambda and charmed quark field solutions, with their respective characteristic Regge trajectories and primary isospin quantum numbers, and a quartet of lepton fields electron neutrino, electron, muon, muon nutrino, are shown to emerge naturally. The equations of motion of the quark and lepton propagators are deduced. The complicated charge nature of the quarks and the need for quark confinement is discussed and a correspondence principle is established between the quark and lepton field solutions. The correspondence is such that the dynamics of the leptons on their own appears to be compatible with quantum electrodynamics on the one hand, and on the other hand permits a natural GIM-Cabibbo weak decay interaction with a Cibibbo angle equal to the domain isospin polarization-change phase angle

  10. Extremal black hole/CFT correspondence in (gauged) supergravities

    International Nuclear Information System (INIS)

    Chow, David D. K.; Cvetic, M.; Lue, H.; Pope, C. N.

    2009-01-01

    We extend the investigation of the recently proposed Kerr/conformal field theory correspondence to large classes of rotating black hole solutions in gauged and ungauged supergravities. The correspondence, proposed originally for four-dimensional Kerr black holes, asserts that the quantum states in the near-horizon region of an extremal rotating black hole are holographically dual to a two-dimensional chiral theory whose Virasoro algebra arises as an asymptotic symmetry of the near-horizon geometry. In fact, in dimension D there are [(D-1)/2] commuting Virasoro algebras. We consider a general canonical class of near-horizon geometries in arbitrary dimension D, and show that in any such metric the [(D-1)/2] central charges each imply, via the Cardy formula, a microscopic entropy that agrees with the Bekenstein-Hawking entropy of the associated extremal black hole. In the remainder of the paper we show for most of the known rotating black hole solutions of gauged supergravity, and for the ungauged supergravity solutions with four charges in D=4 and three charges in D=5, that their extremal near-horizon geometries indeed lie within the canonical form. This establishes that, in all these examples, the microscopic entropies of the dual conformal field theories agree with the Bekenstein-Hawking entropies of the extremal rotating black holes.

  11. Facial Performance Transfer via Deformable Models and Parametric Correspondence.

    Science.gov (United States)

    Asthana, Akshay; de la Hunty, Miles; Dhall, Abhinav; Goecke, Roland

    2012-09-01

    The issue of transferring facial performance from one person's face to another's has been an area of interest for the movie industry and the computer graphics community for quite some time. In recent years, deformable face models, such as the Active Appearance Model (AAM), have made it possible to track and synthesize faces in real time. Not surprisingly, deformable face model-based approaches for facial performance transfer have gained tremendous interest in the computer vision and graphics community. In this paper, we focus on the problem of real-time facial performance transfer using the AAM framework. We propose a novel approach of learning the mapping between the parameters of two completely independent AAMs, using them to facilitate the facial performance transfer in a more realistic manner than previous approaches. The main advantage of modeling this parametric correspondence is that it allows a "meaningful" transfer of both the nonrigid shape and texture across faces irrespective of the speakers' gender, shape, and size of the faces, and illumination conditions. We explore linear and nonlinear methods for modeling the parametric correspondence between the AAMs and show that the sparse linear regression method performs the best. Moreover, we show the utility of the proposed framework for a cross-language facial performance transfer that is an area of interest for the movie dubbing industry.

  12. Difference of cerebral activation between healthy volunteers and MCI-patients during navigation in a virtual reality environment. A parametric study using O15 H2O-PET

    International Nuclear Information System (INIS)

    Drzezga, A.; Wermke, M.D.; Schwaiger, M.; Grimmer, T.; Foerstl, H.; Kurz, A.

    2002-01-01

    Aim: To assess the regional cerebral activation during navigation in a virtual reality (VR) environment in healthy volunteers and patients with mild cognitive impairment (MCI) to identify possible differences in cerebral processing of a complex cognitive task. Materials and Methods: A computer-based VR-system has been developed that allows movements in a virtual labyrinth using a special space-mouse and 3-dimensional perception by shutter-glasses. In 11 healthy, right-handed volunteers (3 female, age 66+/-9 years) and 9 patients with MCI (3 female, 69+/-10 years, diagnosis according to criteria of the Mayo-Clinic) twelve H215O PET-scans were performed (each 370 MBq i.v.-bolus). During the scan subjects had to navigate actively from startpoint to a predefined destination point. Three difficulty levels were presented, 4 times each, in randomized order. Test performance (speed, mistakes) was co-registered. PET data were analyzed using statistical parametric mapping (SPM99, Wellcome Inst., London, UK) including correlation analysis with the acquired test performance results. A significance threshold of p<0,001 uncorrected was applied. Results: In both groups a similar network of extended cerebral activation was identified during active navigation, including maxima in the cerebellum, premotor cortex (Brodmann area [BA] 6), parietal cortex (BA 7, 40) and posterior cingulate cortex (BA 31). However, in MCI-patients a significantly stronger activation of anterior cingulate cortex (BA 24), prefrontal cortex (BA 8) and parietal cortex (BA 40) was observed, as compared to healthy volunteers. Conclusion: The applied combination of PET and VR-technology allows to examine the processing of complex cognitive tasks in the brain. During active navigation significant differences have been observed between the activated cerebral networks in MCI-patients and healthy volunteers. In MCI-patients stronger activation has been identified in cerebral regions associated with attention and

  13. The Aerobic and Cognitive Exercise Study (ACES for Community-Dwelling Older Adults With or At-Risk for Mild Cognitive Impairment (MCI: Neuropsychological, Neurobiological and Neuroimaging Outcomes of a Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Cay Anderson-Hanley

    2018-05-01

    Full Text Available Prior research has found that cognitive benefits of physical exercise and brain health in older adults may be enhanced when mental exercise is interactive simultaneously, as in exergaming. It is unclear whether the cognitive benefit can be maximized by increasing the degree of mental challenge during exercise. This randomized clinical trial (RCT, the Aerobic and Cognitive Exercise Study (ACES sought to replicate and extend prior findings of added cognitive benefit from exergaming to those with or at risk for mild cognitive impairment (MCI. ACES compares the effects of 6 months of an exer-tour (virtual reality bike rides with the effects of a more effortful exer-score (pedaling through a videogame to score points. Fourteen community-dwelling older adults meeting screening criteria for MCI (sMCI were adherent to their assigned exercise for 6 months. The primary outcome was executive function, while secondary outcomes included memory and everyday cognitive function. Exer-tour and exer-score yielded significant moderate effects on executive function (Stroop A/C; d's = 0.51 and 0.47; there was no significant interaction effect. However, after 3 months the exer-tour revealed a significant and moderate effect, while exer-score showed little impact, as did a game-only condition. Both exer-tour and exer-score conditions also resulted in significant improvements in verbal memory. Effects appear to generalize to self-reported everyday cognitive function. Pilot data, including salivary biomarkers and structural MRI, were gathered at baseline and 6 months; exercise dose was associated with increased BDNF as well as increased gray matter volume in the PFC and ACC. Improvement in memory was associated with an increase in the DLPFC. Improved executive function was associated with increased expression of exosomal miRNA-9. Interactive physical and cognitive exercise (both high and low mental challenge yielded similarly significant cognitive benefit for adherent sMCI

  14. The Aerobic and Cognitive Exercise Study (ACES) for Community-Dwelling Older Adults With or At-Risk for Mild Cognitive Impairment (MCI): Neuropsychological, Neurobiological and Neuroimaging Outcomes of a Randomized Clinical Trial.

    Science.gov (United States)

    Anderson-Hanley, Cay; Barcelos, Nicole M; Zimmerman, Earl A; Gillen, Robert W; Dunnam, Mina; Cohen, Brian D; Yerokhin, Vadim; Miller, Kenneth E; Hayes, David J; Arciero, Paul J; Maloney, Molly; Kramer, Arthur F

    2018-01-01

    Prior research has found that cognitive benefits of physical exercise and brain health in older adults may be enhanced when mental exercise is interactive simultaneously, as in exergaming. It is unclear whether the cognitive benefit can be maximized by increasing the degree of mental challenge during exercise. This randomized clinical trial (RCT), the Aerobic and Cognitive Exercise Study (ACES) sought to replicate and extend prior findings of added cognitive benefit from exergaming to those with or at risk for mild cognitive impairment (MCI). ACES compares the effects of 6 months of an exer-tour (virtual reality bike rides) with the effects of a more effortful exer-score (pedaling through a videogame to score points). Fourteen community-dwelling older adults meeting screening criteria for MCI (sMCI) were adherent to their assigned exercise for 6 months. The primary outcome was executive function, while secondary outcomes included memory and everyday cognitive function. Exer-tour and exer-score yielded significant moderate effects on executive function (Stroop A/C; d 's = 0.51 and 0.47); there was no significant interaction effect. However, after 3 months the exer-tour revealed a significant and moderate effect, while exer-score showed little impact, as did a game-only condition. Both exer-tour and exer-score conditions also resulted in significant improvements in verbal memory. Effects appear to generalize to self-reported everyday cognitive function. Pilot data, including salivary biomarkers and structural MRI, were gathered at baseline and 6 months; exercise dose was associated with increased BDNF as well as increased gray matter volume in the PFC and ACC. Improvement in memory was associated with an increase in the DLPFC. Improved executive function was associated with increased expression of exosomal miRNA-9. Interactive physical and cognitive exercise (both high and low mental challenge) yielded similarly significant cognitive benefit for adherent sMCI

  15. Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis.

    Science.gov (United States)

    Ciesielska, Natalia; Sokołowski, Remigiusz; Mazur, Ewelina; Podhorecka, Marta; Polak-Szabela, Anna; Kędziora-Kornatowska, Kornelia

    2016-10-31

    Screening tests play a crucial role in dementia diagnostics, thus they should be very sensitive for mild cognitive impairment (MCI) assessment. Nowadays, the MiniMental State Examination (MMSE) is the most commonly used scale in cognitive function evaluation, albeit it is claimed to be imprecise for MCI detection. The Montreal Cognitive Assessment (MoCA), was created as an alternative method for MMSE. Aim. MoCA vs. MMSE credibility assessment in detecting MCI, while taking into consideration the sensitivity and specificity by cut-off points. A systematic literature search was carried out by the authors using EBSCO host Web, Wiley Online Library, Springer Link, Science Direct and Medline databases. The following medical subject headings were used in the search: mild cognitive impairment, mini-mental state examination, Montreal cognitive assessment, diagnostics value. Papers which met inclusion and exclusion criteria were chosen to be included in this review. At the end, for the evaluation of MoCA 20, and MMSE 13 studies were qualified. Research credibility was established by computing weighted arithmetic mean, where weight is defined as population for which the result of sensitivity and specificity for the cut-off point was achieved. The cut-offs are shown as ROC curve and accuracy of diagnosis for MoCA and MMSE was calculated as the area under the curve (AUC). ROC curve analysis for MoCA demonstrated that MCI best detection can be achieved with a cut-off point of 24/25 (n = 9350, the sensitivity of 80.48% and specificity of 81.19%). AUC was 0.846 (95% CI 0.823-0.868). For MMSE, it turned out that more important cut-off was of 27/28 (n = 882, 66.34% sensitivity and specificity of 72.94%). AUC was 0.736 (95% CI 0.718-0.767). MoCA test better meets the criteria for screening tests for the detection of MCI among patients over 60 years of age than MMSE.

  16. Discrete physics: Practice, representation and rules of correspondence

    International Nuclear Information System (INIS)

    Noyes, H.P.

    1988-07-01

    We make a brief historical review of some aspects of modern physics which we find most significant in our own endeavor. We discuss the ''Yukawa Vertices'' of elementary particle theory as used in laboratory practice, second quantized field theory, analytic S-Matrix theory and in our own approach. We review the conserved quantum numbers in the Standard Model of quarks and leptons. This concludes our presentation of the ''E-frame.'' We try to develop a self-consistent representation of our theory. We have already claimed that this approach provides a discrete reconciliation between the formal (representational) aspects of quantum mechanics and relativity. Also discussed are rules of correspondence connecting the formalism to the practice of physics by using the counter paradigm and event-based coordinates to construct relativistic quantum mechanics in a new way. 31 refs., 12 figs., 1 tab

  17. USING THE FACTORIAL CORRESPONDENCES FOR ANALYZING TOURIST FLOWS

    Directory of Open Access Journals (Sweden)

    Kamer Ainur M. AIVAZ

    2016-06-01

    Full Text Available This study aims to analyze the distribution of each flow of non-residents tourists, coming from 33 countries, on the six main categories of touristic destinations in Romania, in 2015, and assumes that there are differences or similarities between the tourists origin country and the touristic destinations that they chose. The performances recorded in Romania regarding the attraction of foreign tourists were relatively modest during the past three decades, from various reasons, starting with a poor access infrastructure and finishing with a deficient and, sometimes inadequate activity of tourism promotion. The statistical method used is the factorial correspondences analysis. The data processing, the indicators significance testing and the graph representations were performed using SPSS statistical software. We consider that the usage of this method allows the indirect knowledge of the tourist preferences and the results may be useful in developing a strategy for tourism promotion, customized for each country that sends tourists.

  18. Homogeneous nucleation in 4He: A corresponding-states analysis

    International Nuclear Information System (INIS)

    Sinha, D.N.; Semura, J.S.; Brodie, L.C.

    1982-01-01

    We report homogeneous-nucleation-temperature measurements in liquid 4 He over a bath-temperature range 2.31 4 He, in a region far from the critical point. A simple empirical form is presented for estimating the homogeneous nucleation temperatures for any liquid with a spherically symmetric interatomic potential. The 4 He data are compared with nucleation data for Ar, Kr, Xe, and H; theoretical predictions for 3 He are given in terms of reduced quantities. It is shown that the nucleation data for both quantum and classical liquids obey a quantum law of corresponding states (QCS). On the basis of this QCS analysis, predictions of homogeneous nucleation temperatures are made for hydrogen isotopes such as HD, DT, HT, and T 2

  19. Adaptive differential correspondence imaging based on sorting technique

    Directory of Open Access Journals (Sweden)

    Heng Wu

    2017-04-01

    Full Text Available We develop an adaptive differential correspondence imaging (CI method using a sorting technique. Different from the conventional CI schemes, the bucket detector signals (BDS are first processed by a differential technique, and then sorted in a descending (or ascending order. Subsequently, according to the front and last several frames of the sorted BDS, the positive and negative subsets (PNS are created by selecting the relative frames from the reference detector signals. Finally, the object image is recovered from the PNS. Besides, an adaptive method based on two-step iteration is designed to select the optimum number of frames. To verify the proposed method, a single-detector computational ghost imaging (GI setup is constructed. We experimentally and numerically compare the performance of the proposed method with different GI algorithms. The results show that our method can improve the reconstruction quality and reduce the computation cost by using fewer measurement data.

  20. Commensurate scale relations and the Abelian correspondence principle

    International Nuclear Information System (INIS)

    Brodsky, S.J.

    1998-06-01

    Commensurate scale relations are perturbative QCD predictions which relate observable to observable at fixed relative scales, independent of the choice of intermediate renormalization scheme or other theoretical conventions. A prominent example is the generalized Crewther relation which connects the Bjorken and Gross-Llewellyn Smith deep inelastic scattering sum rules to measurements of the e + e - annihilation cross section. Commensurate scale relations also provide an extension of the standard minimal subtraction scheme which is analytic in the quark masses, has non-ambiguous scale-setting properties, and inherits the physical properties of the effective charge α V (Q 2 ) defined from the heavy quark potential. The author also discusses a property of perturbation theory, the Abelian correspondence principle, which provides an analytic constraint on non-Abelian gauge theory for N C → 0

  1. Translating Politeness in Bilingual English-Spanish Business Correspondence

    DEFF Research Database (Denmark)

    Nielsen, Sandro; Fuertes Olivera, Pedro

    2008-01-01

    which pragmatic information types are needed when translating business letters. The analysis focuses on a Spanish-English business dictionary and its treatment of politeness in special sections dealing with business correspondence. The findings show that the treatment is insufficient, because users......Politeness is an important element in interlingual business communication. Translators uae bilingual dictionaries as tools helping them in business discourse across cultures, but dictionaries do not contain the relevant pragmatic information. The functions of dictionaries are used to determine......' business-language competence does not enable them to express the right level of politeness. Bilingual dictionaries should offer a systematic treatment of cultural and genre-specific means of expressing politeness in contrastive, informative texts showing the specific uses of politeness in business...

  2. Aspects of warped AdS3/CFT2 correspondence

    Science.gov (United States)

    Chen, Bin; Zhang, Jia-Ju; Zhang, Jian-Dong; Zhong, De-Liang

    2013-04-01

    In this paper we apply the thermodynamics method to investigate the holographic pictures for the BTZ black hole, the spacelike and the null warped black holes in three-dimensional topologically massive gravity (TMG) and new massive gravity (NMG). Even though there are higher derivative terms in these theories, the thermodynamics method is still effective. It gives consistent results with the ones obtained by using asymptotical symmetry group (ASG) analysis. In doing the ASG analysis we develop a brute-force realization of the Barnich-Brandt-Compere formalism with Mathematica code, which also allows us to calculate the masses and the angular momenta of the black holes. In particular, we propose the warped AdS3/CFT2 correspondence in the new massive gravity, which states that quantum gravity in the warped spacetime could holographically dual to a two-dimensional CFT with {c_R}={c_L}=24 /{Gm{β^2√{{2( {21-4{β^2}} )}}}}.

  3. The New Edition of Chopin’s Correspondence

    Directory of Open Access Journals (Sweden)

    Helman-Bednarczyk Zofia

    2016-12-01

    Full Text Available Some of Fryderyk Chopin’s letters were published individually or in groups already in the 2nd half of the 19th century. With the passage of time, more letters from and to Chopin were printed in monographs dedicated to his life and work. The first editions of Chopin’s collected letters come from the 1st half of the 20th century (by Scharlitt and von Guttry in Germany, Henryk Opieński – in Poland. B.E. Sydow’s Fryderyk Chopin’s Correspondence of 1955 continues to be used as the basic source edition by Chopin biographers. It has many strong points, but has become largely outdated.

  4. The AdS/CFT Correspondence and Holographic QCD

    International Nuclear Information System (INIS)

    Erlich, J.

    2012-01-01

    Holographic QCD is an extra-dimensional approach to modeling QCD resonances and their interactions. Holographic models encode information about chiral symmetry breaking, Weinberg sum rules, vector meson dominance, and other phenomenological features of QCD. There are two complementary approaches to holographic model building: a top-down approach which begins with string-theory brane configurations, and a bottom-up approach which is more phenomenological. In this talk I will describe the AdS/CFT correspondence, which motivates Holographic QCD, and the techniques used to build holographic models of QCD and to calculate observables in those models. I will also discuss an intriguing light cone approach to Holographic QCD discovered by Brodsky and De Teramond. (author)

  5. Plethystic vertex operators and boson-fermion correspondences

    International Nuclear Information System (INIS)

    Fauser, Bertfried; Jarvis, Peter D; King, Ronald C

    2016-01-01

    We study the algebraic properties of plethystic vertex operators, introduced in (2010 J. Phys. A: Math. Theor. 43 405202), underlying the structure of symmetric functions associated with certain generalized universal character rings of subgroups of the general linear group, defined to stabilize tensors of Young symmetry type characterized by a partition of arbitrary shape π . Here we establish an extension of the well-known boson-fermion correspondence involving Schur functions and their associated (Bernstein) vertex operators: for each π , the modes generated by the plethystic vertex operators and their suitably constructed duals, satisfy the anticommutation relations of a complex Clifford algebra. The combinatorial manipulations underlying the results involve exchange identities exploiting the Hopf-algebraic structure of certain symmetric function series and their plethysms. (paper)

  6. The correspondence between Miodrag Vasiljević and Bulgarian Musicians

    Directory of Open Access Journals (Sweden)

    Jovanović Jelena L.

    2002-01-01

    Full Text Available The Serbian ethnomusicologist and music pedagogue Miodrag A. Vasiljević corresponded with colleagues from neighboring Bulgaria between 1934 and 1962. This exchange of letters went through three phases. The first phase was linked with his stay in Skopje until the breakout of World War II; during the second phase - in the course of the 1940's - he was active in the Department for Folk Music at Radio Belgrade and he founded his method of music teaching on traditional Serbian music; in the third phase (the 1950's and beginning of 1960's Vasiljević aimed at a closer cooperation with Bulgarian musicians. All the phases are characterized by his pronounced interest in the folk music heritage of Balkan peoples. At the beginning that interest was focused on popularizing art music that was based on folk music. Later, he enthusiastically carried out his reforms of music teaching in Serbia, as well as improvements of methods in Serbian ethnomusicology.

  7. Fault Correspondence Analysis in Complex Electric Power Systems

    Directory of Open Access Journals (Sweden)

    WANG, C.

    2015-02-01

    Full Text Available Wide area measurement system (WAMS mainly serves for the requirement of time synchronization in complex electric power systems. The analysis and control of power system mostly depends on the measurement of state variables, and WAMS provides the basis for dynamic monitoring of power system by these measurements, which can also satisfy the demands of observable, controllable, real-time analysis and decision, self-adaptive etc. requested by smart grid. In this paper, based on the principles of fault correspondence analysis, by calculating row characteristic which represents nodal electrical information and column characteristic which represents acquisition time information, we will conduct intensive research on fault detection. The research results indicate that the fault location is determined by the first dimensional variable, and the occurrence time of fault is determined by the second dimensional variable. The research in this paper will contribute to the development of future smart grid.

  8. The correspondence between interracial births and multiple-race reporting.

    Science.gov (United States)

    Parker, Jennifer D; Madans, Jennifer H

    2002-12-01

    Race-specific health statistics are routinely reported in scientific publications; most describe health disparities across groups. Census 2000 showed that 2.4% of the US population identifies with more than 1 race group. We examined the hypothesis that multiple-race reporting is associated with interracial births by comparing parental race reported on birth certificates with reported race in a national health survey. US natality data from 1968 through 1998 and National Health Interview Survey data from 1990 through 1998 were compared, by year of birth. Overall multiple-race survey responses correspond to expectations from interracial births. However, there are discrepancies for specific multiple-race combinations. Projected estimates of the multiple-race population can be only partially informed by vital records.

  9. FACTORIAL CORRESPONDENCES ANALYSIS – A TOOL IN TOURISM MOTIVATION RESEARCH

    Directory of Open Access Journals (Sweden)

    Ion Danut I. JUGANARU

    2016-05-01

    Full Text Available This study aims at analyzing the distribution of tourist flows in 2014, from 25 European countries, on three main categories of trip purposes, and assumes that there are differences or similarities between the tourists’ countries of residence and their trip purposes. "Purpose'' is a multidimensional concept used in marketing research, most often for understanding consumer behavior, and for identifying market segments or customer target groups, reunited in terms of similar characteristics. Being aware that the decision of choice/ purchase is based on purposes, their knowledge proves useful in designing strategies to increase the satisfaction level provided to the customer. The statistical method used in this paper is the factorial correspondences analysis. In our opinion, the identification, by this method, of the existence of differences or similarities between the tourists’ countries of residence and their trip purposes can represent a useful step in studying the tourism market and the choice/ reformulation of strategies.

  10. The GL(1 vertical stroke 1)-symplectic fermion correspondence

    International Nuclear Information System (INIS)

    Creutzig, Thomas; Roenne, Peter B.

    2008-12-01

    In this note we prove a correspondence between the Wess-Zumino-Novikov-Witten model of the Lie supergroup GL(1 vertical stroke 1) and a free model consisting of two scalars and a pair of symplectic fermions. This model was discussed earlier by LeClair. Vertex operators for the symplectic fermions include twist fields, and correlation functions of GL(1 vertical stroke 1) agree with the known results for the scalars and symplectic fermions. We perform a detailed study of boundary states for symplectic fermions and apply them to branes in GL(1 vertical stroke 1). This allows us to compute new amplitudes of strings stretching between branes of different types and confirming Cardy's condition. (orig.)

  11. A recurrent dynamic model for correspondence-based face recognition.

    Science.gov (United States)

    Wolfrum, Philipp; Wolff, Christian; Lücke, Jörg; von der Malsburg, Christoph

    2008-12-29

    Our aim here is to create a fully neural, functionally competitive, and correspondence-based model for invariant face recognition. By recurrently integrating information about feature similarities, spatial feature relations, and facial structure stored in memory, the system evaluates face identity ("what"-information) and face position ("where"-information) using explicit representations for both. The network consists of three functional layers of processing, (1) an input layer for image representation, (2) a middle layer for recurrent information integration, and (3) a gallery layer for memory storage. Each layer consists of cortical columns as functional building blocks that are modeled in accordance with recent experimental findings. In numerical simulations we apply the system to standard benchmark databases for face recognition. We find that recognition rates of our biologically inspired approach lie in the same range as recognition rates of recent and purely functionally motivated systems.

  12. The GL(1 vertical stroke 1)-symplectic fermion correspondence

    Energy Technology Data Exchange (ETDEWEB)

    Creutzig, Thomas; Roenne, Peter B.

    2008-12-15

    In this note we prove a correspondence between the Wess-Zumino-Novikov-Witten model of the Lie supergroup GL(1 vertical stroke 1) and a free model consisting of two scalars and a pair of symplectic fermions. This model was discussed earlier by LeClair. Vertex operators for the symplectic fermions include twist fields, and correlation functions of GL(1 vertical stroke 1) agree with the known results for the scalars and symplectic fermions. We perform a detailed study of boundary states for symplectic fermions and apply them to branes in GL(1 vertical stroke 1). This allows us to compute new amplitudes of strings stretching between branes of different types and confirming Cardy's condition. (orig.)

  13. Plethystic vertex operators and boson-fermion correspondences

    Science.gov (United States)

    Fauser, Bertfried; Jarvis, Peter D.; King, Ronald C.

    2016-10-01

    We study the algebraic properties of plethystic vertex operators, introduced in (2010 J. Phys. A: Math. Theor. 43 405202), underlying the structure of symmetric functions associated with certain generalized universal character rings of subgroups of the general linear group, defined to stabilize tensors of Young symmetry type characterized by a partition of arbitrary shape π. Here we establish an extension of the well-known boson-fermion correspondence involving Schur functions and their associated (Bernstein) vertex operators: for each π, the modes generated by the plethystic vertex operators and their suitably constructed duals, satisfy the anticommutation relations of a complex Clifford algebra. The combinatorial manipulations underlying the results involve exchange identities exploiting the Hopf-algebraic structure of certain symmetric function series and their plethysms.

  14. Corresponding Angle Feedback in an innovative weighted transportation system

    International Nuclear Information System (INIS)

    Dong Chuanfei; Ma Xu

    2010-01-01

    The optimal information feedback has a significant effect on many socioeconomic systems like stock market and traffic systems aiming to make full use of resources. In this Letter, we study dynamics of traffic flow with real-time information. The influence of a feedback strategy named Corresponding Angle Feedback Strategy (CAFS) is introduced, based on a two-route scenario in which dynamic information can be generated and displayed on the board to guide road users to make a choice. Our model incorporates the effects of adaptability into the cellular automaton models of traffic flow and simulation results adopting this optimal information feedback strategy have demonstrated high efficiency in controlling spatial distribution of traffic patterns compared with the other three information feedback strategies, i.e., vehicle number and flux.

  15. Fair Value and the Missing Correspondence between Accounting and Auditing

    DEFF Research Database (Denmark)

    Liempd, Dennis van; Jeppesen, Kim Klarskov

    . The second turning point is from historical cost to fair values, which changes the ontological premises of accounting thought in the direction of ontological subjectivity. This has profound consequences for auditing, which so far has failed to develop new epistemic criteria to deal with fair value accounting’s......The paper outlines the history of accounting and auditing thought, demonstrating how auditing has had an isomorphic relationship with accounting throughout most of its history. We focus this history on two turning points. The first is the turn from reporting the truth to reporting in accordance...... with Generally Accepted Accounting Principles, which occurred in the 1960s as a result of the politicization of accounting standard setting. We argue that auditing adapted to this change by establishing a conceptual framework based on checking the correspondence between assertions and established criteria...

  16. DLP system and the secret of personal correspondence

    Directory of Open Access Journals (Sweden)

    Mavrinskaya T.V.

    2017-04-01

    Full Text Available according to the authors, every day a number of threats to information security increases, and this requires an increase in resources (systems of information protection of organizations and enterprises. There are many information security tools with different functionality, but the main mean of preventing information leakage is the Date Loss Prevention (DLP system. If you need to establish control over the leak of confidential information there appear a number of questions of conformity of decisions with the legislation and regulations. This article describes the issue of compliance functionality of a DLP system the provisions and requirements of the legislation in the sphere of protection of family and personal secrets, as well as compliance with the Constitutional right of citizens to privacy of correspondence.

  17. Discrete physics: Practice, representation and rules of correspondence

    Energy Technology Data Exchange (ETDEWEB)

    Noyes, H.P.

    1988-07-01

    We make a brief historical review of some aspects of modern physics which we find most significant in our own endeavor. We discuss the ''Yukawa Vertices'' of elementary particle theory as used in laboratory practice, second quantized field theory, analytic S-Matrix theory and in our own approach. We review the conserved quantum numbers in the Standard Model of quarks and leptons. This concludes our presentation of the ''E-frame.'' We try to develop a self-consistent representation of our theory. We have already claimed that this approach provides a discrete reconciliation between the formal (representational) aspects of quantum mechanics and relativity. Also discussed are rules of correspondence connecting the formalism to the practice of physics by using the counter paradigm and event-based coordinates to construct relativistic quantum mechanics in a new way. 31 refs., 12 figs., 1 tab.

  18. Language Training - French Training

    CERN Document Server

    2007-01-01

    General and Professional French Courses The next session will take place from 29 January to 30 March 2007. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz : Tel. 73127. Writing Professional Documents in French The next session will take place from 29 January to 30 March 2007. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF (for 8 students) For further information and registration, please consult our Web pages:   http://cern.ch/Training or contact Mrs. Benz : Tel. 73127. Writing Professional Documents in English The next session will take place from January to June 2007 (break at Easter). This course is designed for people with a good level of spoken English. Duration: 30 hours Price: 660 CHF (for 8 students) Timetable will be fixed after discussion with the students. For registratio...

  19. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For further information, please contact Mr. Liptow, tel. 72957. Date and timetable will be fixed when there are sufficient participants enrolled. FORMATION EN LANGUES LANGUAGE TRAINING Françoise Benz 73127 langua...

  20. Language Training: English Training

    CERN Document Server

    Françoise Benz

    2004-01-01

    General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For further information, please contact Mr. Liptow, tel. 72957. Date and timetable will be fixed when there are sufficient participants enrolled. FORMATION EN LANGUES LANGUAGE TRAINING Françoise Benz 73127 languag...

  1. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    La prochaine session se déroulera du 04 octobre 2004 au 11 février 2005 (interruption de 3 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web : http://cern.ch/Training Vous pouvez aussi contacter M. Liptow, tél. 72957. General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants ...

  2. Crisis and Correspondence: Style in the Nineteenth Century

    Directory of Open Access Journals (Sweden)

    Mari Hvattum

    2013-10-01

    Full Text Available In his manifesto 'Das Kunstwerk der Zukunft' (1850, Richard Wagner characterised the nineteenth century as a time of crisis. Echoing Saint-Simon, he defined this crisis as a discrepancy between the spirit of the age and the actual, historical conditions. Evoking some of the most potent concepts of modern thinking—Zeitgeist, genius, and the Gesamtkunstwerk—Wagner outlined an aesthetic theory by which the artwork (including architecture simultaneously reflects and shapes its context, serving both as a mirror of its age and an agent of change.      Wagner’s seemingly paradoxical notion of art provides an apt introduction to historicist thinking. Obsessed with the idea of correspondence (or the lack of it between art and its times, nineteenth-century thinkers such as Heinrich Hübsch, Carl Bötticher and Gottfried Semper all responded to the perceived crisis. While Hübsch and Bötticher sought to alleviate the crisis by redefining this correspondence for a modern world, Semper presented a far more radical alternative. Not only did he see the current crisis as inevitable; he welcomed it as a necessary dissolution of an old order, out of which a new architecture could emerge. He thus anticipated modernists, such as Sigfried Giedion, for whom historicism was a necessary melt-down; an apocalypse, preparing for the advent of modernism. In this essay, I propose that crisis and style are intrinsically linked in modern thinking. To look closely at this coupling may throw new light not only on historicism but also on the noticeable unease with which the notion of style is treated in contemporary architectural history.

  3. Identificação do gene mcyA em florações naturais de Radiocystis fernandoi, em um tributário do reservatório de Rosana, Brasil - doi: 10.4025/actascibiolsci.v33i3.6802 Identification of the mcyA gene in natural blooms of Radiocystis fernandoi from a tributary of the Rosana reservoir, Brazil - doi: 10.4025/actascibiolsci.v33i3.6802

    Directory of Open Access Journals (Sweden)

    Sônia Maria Alves Pinto Prioli

    2011-07-01

    Full Text Available As cianobactérias são conhecidamente produtoras de toxinas. Dentro de uma mesma espécie, podemos encontrar variedades tóxicas e não-tóxicas, impossíveis de diferenciação apenas pela morfologia. A principal toxina produzida pelas cianobactérias é a microcistina. Esta proteína é biossintetizada por um grupo de genes conhecidos como mcy. A detecção destes genes a partir de PCR permite a distinção das variedades tóxicas e não-tóxicas. Desse modo, o objetivo desse trabalho foi investigar a ocorrência de florações produtoras de toxinas em um rio tributário do reservatório de Rosana, via amplificação do gene mcyA por PCR. Foram coletadas duas amostras de água da subsuperfície. As duas amostras coletadas no rio do Corvo foram dominadas pela espécie Radiocystis fernandoi e apresentaram resultados positivos para a presença do gene mcyA, confirmando o potencial tóxico dessa espécie. Os resultados representam alerta sobre a qualidade da água do rio do Corvo. A técnica PCR foi eficiente para a rápida detecção de cianobactérias produtoras de toxinas, inclusive podendo ser utilizada antes mesmo do agravamento das condições ambientais pela produção de toxinas, além de apresentar baixo custo.Cyanobacterias are known as toxin producers. Within the same species, toxic and non-toxic varieties can be found and it is impossible to differentiate them only by morphology. The most important toxin produced by cyanobacteria is microcystin. This protein is synthesized by a cluster of genes known as mcy. The detection of these genes by PCR allows the differentiation of the producing toxin strain from the non-producing toxin strain. Thus, the goal of this work was to investigate the occurrence of toxigenic blooms of cyanobacteria in the Corvo River through PCR amplification of mcyA gene. For this, two samples of blooms of cyanobacteria were collected in Corvo River. Both samples were dominated by Radiocystis fernandoi and presented

  4. Simultaneous fitting of a potential-energy surface and its corresponding force fields using feedforward neural networks

    Science.gov (United States)

    Pukrittayakamee, A.; Malshe, M.; Hagan, M.; Raff, L. M.; Narulkar, R.; Bukkapatnum, S.; Komanduri, R.

    2009-04-01

    An improved neural network (NN) approach is presented for the simultaneous development of accurate potential-energy hypersurfaces and corresponding force fields that can be utilized to conduct ab initio molecular dynamics and Monte Carlo studies on gas-phase chemical reactions. The method is termed as combined function derivative approximation (CFDA). The novelty of the CFDA method lies in the fact that although the NN has only a single output neuron that represents potential energy, the network is trained in such a way that the derivatives of the NN output match the gradient of the potential-energy hypersurface. Accurate force fields can therefore be computed simply by differentiating the network. Both the computed energies and the gradients are then accurately interpolated using the NN. This approach is superior to having the gradients appear in the output layer of the NN because it greatly simplifies the required architecture of the network. The CFDA permits weighting of function fitting relative to gradient fitting. In every test that we have run on six different systems, CFDA training (without a validation set) has produced smaller out-of-sample testing error than early stopping (with a validation set) or Bayesian regularization (without a validation set). This indicates that CFDA training does a better job of preventing overfitting than the standard methods currently in use. The training data can be obtained using an empirical potential surface or any ab initio method. The accuracy and interpolation power of the method have been tested for the reaction dynamics of H+HBr using an analytical potential. The results show that the present NN training technique produces more accurate fits to both the potential-energy surface as well as the corresponding force fields than the previous methods. The fitting and interpolation accuracy is so high (rms error=1.2 cm-1) that trajectories computed on the NN potential exhibit point-by-point agreement with corresponding

  5. Crane and Excavator Operator.

    Science.gov (United States)

    Marine Corps Inst., Washington, DC.

    Developed as part of the Marine Corps Institute (MCI) correspondence training program, this course on crane and excavator operation is designed to enable the crane and excavator operator to perform his/her duties more proficiently. Introductory materials include specific information for MCI students, a course introduction, and a study guide…

  6. Salads, Sandwiches and Desserts.

    Science.gov (United States)

    Marine Corps Inst., Washington, DC.

    Developed as part of the Marine Corps Institute (MCI) correspondence training program, this course on salads, sandwiches, and desserts is designed to provide Marine food service personnel with a general background in the proper techniques for the preparation of these items. Introductory materials include specific information for MCI students and a…

  7. Snake Train

    Institute of Scientific and Technical Information of China (English)

    李鲁

    1993-01-01

    The Parisian Transit Authority (RATP) has beguntesting a new train it hopes will be the 'metro① of theyear 2000': a 150-foot-long continuous tube dubbed② the'Boa.' The train is not sectioned off into cars③, thusallowing as many as 890 passengers to walk from one endof the Boa to the other. Swiveling axles beneath the train

  8. Marginalia, commonplaces, and correspondence: scribal exchange in early modern science.

    Science.gov (United States)

    Yale, Elizabeth

    2011-06-01

    In recent years, historians of science have increasingly turned their attention to the "print culture" of early modern science. These studies have revealed that printing, as both a technology and a social and economic system, structured the forms and meanings of natural knowledge. Yet in early modern Europe, naturalists, including John Aubrey, John Evelyn, and John Ray, whose work is discussed in this paper, often shared and read scientific texts in manuscript either before or in lieu of printing. Scribal exchange, exemplified in the circulation of writings like commonplace books, marginalia, manuscript treatises, and correspondence, was the primary means by which communities of naturalists constructed scientific knowledge. Print and manuscript were necessary partners. Manuscript fostered close collaboration, and could be circulated relatively cheaply; but, unlike print, it could not reliably secure priority or survival for posterity. Naturalists approached scribal and print communication strategically, choosing the medium that best suited their goals at any given moment. As a result, print and scribal modes of disseminating information, constructing natural knowledge, and organizing communities developed in tandem. Practices typically associated with print culture manifested themselves in scribal texts and exchanges, and vice versa. "Print culture" cannot be hived off from "scribal culture." Rather, in their daily jottings and exchanges, naturalists inhabited, and produced, one common culture of communication. Copyright © 2010 Elsevier Ltd. All rights reserved.

  9. The law of corresponding states and surface tension of metals

    International Nuclear Information System (INIS)

    Digilov, R.

    2001-01-01

    Full Text: Surface tension of liquid metals is one of fundamental and most important quantities in theory and practice of material processing and its temperature dependence leads to the well-known Marangoni convection. Although currently methods are sufficiently precise to measure the surface tension, there are uncertainties in experimental data and its temperature dependence mainly due to impurity, which even a trace of it strongly affects the results of measurements. The theoretical treatment from the first principles is unwieldy and not always permits one to calculate the surface tension with certainty. Another active research field deals with empirical correlation between the surface tension and bulk thermodynamic properties, which we interpret as a simple consequence of the law of corresponding states. In order to relate the surface tension and to bulk properties of liquid metals the reduced formula is derived by scaling with the melting point T m (0) at p = 0 and atomic volume Ω 0 2/3 at T = 0 K as macroscopic parameters for scaling ε and a characterizing the interatomic potential in metals. The reduced surface tension and the reduced surface entropy obtained in high temperature limit are discussed and compared with the experiment. The reduced temperature coefficient of the surface tension found is a universal constant for the metals of the same structure. It is shown that pressure dependence of the surface tension, so called baric coefficient of the surface tension, can be described by pressure dependence of scaling parameters T m (p) and Ω 0 (p). (author)

  10. Object-Image Correspondence for Algebraic Curves under Projections

    Directory of Open Access Journals (Sweden)

    Joseph M. Burdis

    2013-03-01

    Full Text Available We present a novel algorithm for deciding whether a given planar curve is an image of a given spatial curve, obtained by a central or a parallel projection with unknown parameters. The motivation comes from the problem of establishing a correspondence between an object and an image, taken by a camera with unknown position and parameters. A straightforward approach to this problem consists of setting up a system of conditions on the projection parameters and then checking whether or not this system has a solution. The computational advantage of the algorithm presented here, in comparison to algorithms based on the straightforward approach, lies in a significant reduction of a number of real parameters that need to be eliminated in order to establish existence or non-existence of a projection that maps a given spatial curve to a given planar curve. Our algorithm is based on projection criteria that reduce the projection problem to a certain modification of the equivalence problem of planar curves under affine and projective transformations. To solve the latter problem we make an algebraic adaptation of signature construction that has been used to solve the equivalence problems for smooth curves. We introduce a notion of a classifying set of rational differential invariants and produce explicit formulas for such invariants for the actions of the projective and the affine groups on the plane.

  11. Apparatus and method for comparing corresponding acoustic resonances in liquids

    Science.gov (United States)

    Sinha, Dipen N.

    1999-01-01

    Apparatus and method for comparing corresponding acoustic resonances in liquids. The present invention permits the measurement of certain characteristics of liquids which affect the speed of sound therein. For example, a direct correlation between the octane rating of gasoline and the speed of sound in a gasoline sample has been experimentally observed. Therefore, changes in the speed of sound therein can be utilized as a sensitive parameter for determining changes in composition of a liquid sample. The present apparatus establishes interference patterns inside of a liquid without requiring the use of very thin, rigorously parallel ceramic discs, but rather uses readily available piezoelectric transducers attached to the outside surface of the usual container for the liquid and located on the same side thereof in the vicinity of one another. That is, various receptacle geometries may be employed, and the driving and receiving transducers may be located on the same side of the receptacle. The cell may also be constructed of any material that is inert to the liquid under investigation. A single-transducer embodiment, where the same transducer provides the excitation to the sample container and receives signals impressed therein, is also described.

  12. The Kerr/CFT Correspondence and its Extensions

    Directory of Open Access Journals (Sweden)

    Geoffrey Compère

    2012-10-01

    Full Text Available We present a first-principles derivation of the main results of the Kerr/CFT correspondence and its extensions using only tools from gravity and quantum field theory, filling a few gaps in the literature when necessary. Firstly, we review properties of extremal black holes that imply, according to semi-classical quantization rules, that their near-horizon quantum states form a centrally-extended representation of the one-dimensional conformal group. This motivates the conjecture that the extremal Kerr and Reissner–Nordström black holes are dual to the chiral limit of a two-dimensional CFT. We also motivate the existence of an SL (2,ℤ family of two-dimensional CFTs, which describe in their chiral limit the extremal Kerr–Newman black hole. We present generalizations in anti-de Sitter spacetime and discuss other matter-coupling and higher-derivative corrections. Secondly, we show how a near-chiral limit of these CFTs reproduces the dynamics of near-superradiant probes around near-extremal black holes in the semi-classical limit. Thirdly, we review how the hidden conformal symmetries of asymptotically-flat black holes away from extremality, combined with their properties at extremality, allow for a microscopic accounting of the entropy of non-extremal asymptotically-flat rotating or charged black holes. We conclude with a list of open problems.

  13. The correspondence between Winkler and Monakow during World War I.

    Science.gov (United States)

    Koehler, Peter J; Jagella, Caroline

    2015-01-01

    The correspondence (1907-1930) between two leading European neurologists, Cornelis Winkler (1855-1941) and Constantin von Monakow (1853-1930), has been preserved in Amsterdam and Zurich. For this paper, letters exchanged during World War I were studied. Professional as well as personal issues were discussed. An international neurology meeting in Berne in September 1914 had to be cancelled due to the war. They hoped that (neuro)scientists would remain politically neutral, continue scientific cooperation, and even be able to influence the course of the war. Winkler and Monakow tried to continue their work on the International Brain Atlas. Although living in neutral countries (The Netherlands and Switzerland), they observed that their practice and scientific work suffered from war conditions. While Winkler continued his activities as a neurologist, Monakow, affected emotionally, experienced a change in scientific interest toward psychoneurology. He used his diaschisis concept, originally an explanation for transient phenomena in stroke, as a metaphor for the social and cultural effects of the war. He directly related cultural development and brain science, bringing in his own emotions, which resulted in the first of several publications on the relations between biology, brain science, and culture.

  14. Exploring the tensor networks/AdS correspondence

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharyya, Arpan [Department of Physics and Center for Field Theory and Particle Physics, Fudan University,220 Handan Road, 200433 Shanghai (China); Centre For High Energy Physics, Indian Institute of Science,560012 Bangalore (India); Gao, Zhe-Shen [Department of Physics and Center for Field Theory and Particle Physics, Fudan University,220 Handan Road, 200433 Shanghai (China); Hung, Ling-Yan [Department of Physics and Center for Field Theory and Particle Physics, Fudan University,220 Handan Road, 200433 Shanghai (China); State Key Laboratory of Surface Physics and Department of Physics, Fudan University,220 Handan Road, 200433 Shanghai (China); Collaborative Innovation Center of Advanced Microstructures, Nanjing University,Nanjing, 210093 (China); Liu, Si-Nong [Department of Physics and Center for Field Theory and Particle Physics, Fudan University,220 Handan Road, 200433 Shanghai (China)

    2016-08-11

    In this paper we study the recently proposed tensor networks/AdS correspondence. We found that the Coxeter group is a useful tool to describe tensor networks in a negatively curved space. Studying generic tensor network populated by perfect tensors, we find that the physical wave function generically do not admit any connected correlation functions of local operators. To remedy the problem, we assume that wavefunctions admitting such semi-classical gravitational interpretation are composed of tensors close to, but not exactly perfect tensors. Computing corrections to the connected two point correlation functions, we find that the leading contribution is given by structures related to geodesics connecting the operators inserted at the boundary physical dofs. Such considerations admit generalizations at least to three point functions. This is highly suggestive of the emergence of the analogues of Witten diagrams in the tensor network. The perturbations alone however do not give the right entanglement spectrum. Using the Coxeter construction, we also constructed the tensor network counterpart of the BTZ black hole, by orbifolding the discrete lattice on which the network resides. We found that the construction naturally reproduces some of the salient features of the BTZ black hole, such as the appearance of RT surfaces that could wrap the horizon, depending on the size of the entanglement region A.

  15. Perceptual load corresponds with factors known to influence visual search.

    Science.gov (United States)

    Roper, Zachary J J; Cosman, Joshua D; Vecera, Shaun P

    2013-10-01

    One account of the early versus late selection debate in attention proposes that perceptual load determines the locus of selection. Attention selects stimuli at a late processing level under low-load conditions but selects stimuli at an early level under high-load conditions. Despite the successes of perceptual load theory, a noncircular definition of perceptual load remains elusive. We investigated the factors that influence perceptual load by using manipulations that have been studied extensively in visual search, namely target-distractor similarity and distractor-distractor similarity. Consistent with previous work, search was most efficient when targets and distractors were dissimilar and the displays contained homogeneous distractors; search became less efficient when target-distractor similarity increased irrespective of display heterogeneity. Importantly, we used these same stimuli in a typical perceptual load task that measured attentional spillover to a task-irrelevant flanker. We found a strong correspondence between search efficiency and perceptual load; stimuli that generated efficient searches produced flanker interference effects, suggesting that such displays involved low perceptual load. Flanker interference effects were reduced in displays that produced less efficient searches. Furthermore, our results demonstrate that search difficulty, as measured by search intercept, has little bearing on perceptual load. We conclude that rather than be arbitrarily defined, perceptual load might be defined by well-characterized, continuous factors that influence visual search. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  16. A composition algorithm based on crossmodal taste-music correspondences

    Directory of Open Access Journals (Sweden)

    Bruno eMesz

    2012-04-01

    Full Text Available While there is broad consensus about the structural similarities between language and music, comparably less attention has been devoted to semantic correspondences between these two ubiquitous manifestations of human culture. We have investigated the relations between music and a narrow and bounded domain of semantics: the words and concepts referring to taste sensations. In a recent work, we found that taste words were consistently mapped to musical parameters. Bitter is associated with low-pitched and continuous music (legato, salty is characterized by silences between notes (staccato, sour is high pitched, dissonant and fast and sweet is consonant, slow and soft (Mesz2011. Here we extended these ideas, in a synergistic dialog between music and science, investigating whether music can be algorithmically generated from taste-words. We developed and implemented an algorithm that exploits a large corpus of classic and popular songs. New musical pieces were produced by choosing fragments from the corpus and modifying them to minimize their distance to the region in musical space that characterizes each taste. In order to test the capability of the produced music to elicit significant associations with the different tastes, musical pieces were produced and judged by a group of non musicians. Results showed that participants could decode well above chance the taste-word of the composition. We also discuss how our findings can be expressed in a performance bridging music and cognitive science.

  17. Dental Pulp: Correspondences and Contradictions between Clinical and Histological Diagnosis

    Science.gov (United States)

    Giuroiu, Cristian Levente; Căruntu, Irina-Draga; Lozneanu, Ludmila; Melian, Anca; Vataman, Maria; Andrian, Sorin

    2015-01-01

    Dental pulp represents a specialized connective tissue enclosed by dentin and enamel, the most highly mineralized tissues of the body. Consequently, the direct examination as well as pathological evaluation of dental pulp is difficult. Within this anatomical context, our study aimed to evaluate the correlation between dental pulp lesions and clinical diagnosis. Pulpectomies were performed for 54 patients with acute and chronic irreversible pulpitides and for 5 patients (control group) with orthodontic extractions. The morphological features were semiquantitatively assessed by specific score values. The clinical and morphological correspondence was noted for 35 cases (68.62%), whereas inconsistency was recorded for 16 cases (31.38%). The results of the statistical analysis revealed the correlations between clinically and pathologically diagnosed acute/chronic pulpitides. No significant differences were established between the score values for inflammatory infiltrate intensity, collagen depositions, calcifications and necrosis, and acute, respectively chronic pulpitides. We also obtained significant differences between acute pulpitides and inflammatory infiltrate and calcifications and between chronic pulpitides and inflammatory infiltrate, collagen deposition, and calcifications. On the basis of the predominant pathological aspects, namely, acute and chronic pulpitis, we consider that the classification schemes can be simplified by adequately reducing the number of clinical entities. PMID:26078972

  18. The lattice correspondence and diffusional-displacive phase transformations

    International Nuclear Information System (INIS)

    Nie, J.F.; Muddle, B.C.

    1999-01-01

    When a coherent interface is maintained between parent and product phases in a solid state phase transformation, then it is always possible to define a lattice correspondence across this interface and describe the structural change by a homogeneous lattice deformation, S T . For certain transformations, this strain is an invariant plane strain, with the invariant plane defining the planar, coherent interface between parent and product. This group includes the familiar martensitic face-centred cubic to close-packed hexagonal transformation in, for example, cobalt-based alloys, but it is demonstrated here that it also contains transformations giving rise to a broad range of plate-shaped, diffusional precipitation products. For many such transformation products, the transformation strain has a significant shear component and the accommodation of shear strain energy is potentially an important, and often overlooked, factor in both the nucleation and growth of such products. More commonly S T is not an invariant plane strain and, if a planar interface is to be preserved between parent and product, it is necessary to combine S T with a lattice invariant strain to allow a partially-coherent interface that is macroscopically invariant. It is demonstrated that there are diffusional transformation products which also have the geometric and crystallographic features of both of the common forms of partially-coherent martensitic products

  19. Scaffolding in Business English Correspondence Classes at College Level

    Directory of Open Access Journals (Sweden)

    Eric Sulindra Widjojokoesoemo

    2015-11-01

    Full Text Available Language teaching and education have been so long influenced by developmental psychology, namely constructivism. This idea enlightens the world of language teaching. Constructivism has received both praises and critics. Communicative approach followers claim that the principles in constructivism support their thoughts while the followers of a more traditional approach, namely, Grammar Translation Method, claim that the constructivism is just another experiment in language teaching, just like other methods. This article is based on a classroom action research investigation of how scaffolding instruction, the operational ‘terms’ of constructivism, based on its ‘ZPD’ (Zone of Proximal Development, play roles in language teaching, specifically in Business English Writing. The investigation has perceived several important aspects in scaffolding instruction for teaching Business English Correspondence, such as the importance of modeling or giving examples, as well as corrective and immediate feedback, together with positive reinforcement, to improve the learners’ performance. It showed that modeling or giving examples, peer reviewing, together with immediate feedback, brought significant influence on the learners’ perspective, about their learning performance. Keywords: constructivism, Scaffolding, ZPD, Business English Writing

  20. Corresponding control of the administration - procedural development and deadlocks

    International Nuclear Information System (INIS)

    Breuer, R.

    1980-01-01

    The author proceeds from a decision of the Higher Administrative Court of Lueneburg of February 2, 1979 which limits the execution of a partial construction permit for a nuclear power plant to the extent that 'the approved plant components may and will only be used under certain conditions'. He critically reflects on the development of administrative legal protection. In principle, corresponding control of the administration leads to a latent change in the function of appeals aiming at cassation. As a rule, this is not against the law, since sect. 80 of the VwGO acknowledges 'individual interim regulations'. In this case it is a condition of a cancelling nature. The discussion of acknowledged and problematic cases of judicial decisions made under certain conditions is followed by the explanation that the Higher Administrative Court of Lueneburg has delegated the decision which is incumbent upon the Court to the Commission on Reactor Safety. Such a delegation of jurisdiction is contradictory to the constitutional postulate of Art. 19/IV and 91 of the Basic Law. (HSCH) [de

  1. Bulk-edge correspondence in topological transport and pumping

    Science.gov (United States)

    Imura, Ken-Ichiro; Yoshimura, Yukinori; Fukui, Takahiro; Hatsugai, Yasuhiro

    2018-03-01

    The bulk-edge correspondence (BEC) refers to a one-to-one relation between the bulk and edge properties ubiquitous in topologically nontrivial systems. Depending on the setup, BEC manifests in different forms and govern the spectral and transport properties of topological insulators and semimetals. Although the topological pump is theoretically old, BEC in the pump has been established just recently [1] motivated by the state-of-the-art experiments using cold atoms [2, 3]. The center of mass (CM) of a system with boundaries shows a sequence of quantized jumps in the adiabatic limit associated with the edge states. Despite that the bulk is adiabatic, the edge is inevitably non-adiabatic in the experimental setup or in any numerical simulations. Still the pumped charge is quantized and carried by the bulk. Its quantization is guaranteed by a compensation between the bulk and edges. We show that in the presence of disorder the pumped charge continues to be quantized despite the appearance of non-quantized jumps.

  2. CFT/gravity correspondence on the isolated horizon

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, Amit, E-mail: amit.ghosh@saha.ac.in [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, 700064 Kolkata (India); Pranzetti, Daniele, E-mail: daniele.pranzetti@gravity.fau.de [Institute for Quantum Gravity, University of Erlangen-Nürnberg (FAU), Staudtstrasse 7/B2, 91058 Erlangen (Germany)

    2014-12-15

    A quantum isolated horizon can be modelled by an SU(2) Chern–Simons theory on a punctured 2-sphere. We show how a local 2-dimensional conformal symmetry arises at each puncture inducing an infinite set of new observables localised at the horizon which satisfy a Kac–Moody algebra. By means of the isolated horizon boundary conditions, we represent the gravitational flux degrees of freedom in terms of the zero modes of the Kac–Moody algebra defined on the boundary of a punctured disk. In this way, our construction encodes a precise notion of CFT/gravity correspondence. The higher modes in the algebra represent new nongeometric charges which can be represented in terms of free matter field degrees of freedom. When computing the CFT partition function of the system, these new states induce an extra degeneracy factor, representing the density of horizon states at a given energy level, which reproduces the Bekenstein's holographic bound for an imaginary Immirzi parameter. This allows us to recover the Bekenstein–Hawking entropy formula without the large quantum gravity corrections associated with the number of punctures.

  3. Intrahepatic cholangiocarcinoma : gross appearance and corresponding pathologic and radiologic features

    International Nuclear Information System (INIS)

    Yoon, Kwon Ha; Kim, Chang Guhn; Lee, Moon Gyu; Ha, Hyun Kwon; Auh, Yong Ho; Lim, Jae Hoon

    1999-01-01

    To assess the clinical and pathologic features of each type of intrahepatic cholangiocarcinoma, which is divided into three types according to gross appearance, and to determine the efficacy of CT in detecting this tumor. The pathologic and CT features of 53 surgically proven cases of intrahepatic cholangio-carcinoma were reviewed. On the basis of their gross appearance, the tumors were divided into three types, as follows : mass forming (n=33), periductal infiltrating (n=6), and intraductal growth type (n=14). CT scans were analyzed for sensitivity of detection and correlation between a tumors appearance and its histopathology. The most common histopathologic feature of mass forming and periductal infiltrating type was tubular adenocarcinoma, while in the intraductal growth type, papillary adenocarcinoma (100%) was common. With regard to pattern of tumor spread, intrahepatic and lymph node metastasis were more common in the mass forming and periductal infiltrating type than in the intraductal growth type. CT findings including intrahepatic mass, ductal wall thickening or intraductal mass associated with segmental dilatation of intrahepataic bile ducts, corresponded with these morphologic types. This classification according to gross appearance is of considerable value when interpreting the pathologic features of intrahepatic cholangiocarcinoma. CT seems to be a useful modality for the detection of tumors and may be consistent with their gross morphologic findings

  4. Two-Way Regularized Fuzzy Clustering of Multiple Correspondence Analysis.

    Science.gov (United States)

    Kim, Sunmee; Choi, Ji Yeh; Hwang, Heungsun

    2017-01-01

    Multiple correspondence analysis (MCA) is a useful tool for investigating the interrelationships among dummy-coded categorical variables. MCA has been combined with clustering methods to examine whether there exist heterogeneous subclusters of a population, which exhibit cluster-level heterogeneity. These combined approaches aim to classify either observations only (one-way clustering of MCA) or both observations and variable categories (two-way clustering of MCA). The latter approach is favored because its solutions are easier to interpret by providing explicitly which subgroup of observations is associated with which subset of variable categories. Nonetheless, the two-way approach has been built on hard classification that assumes observations and/or variable categories to belong to only one cluster. To relax this assumption, we propose two-way fuzzy clustering of MCA. Specifically, we combine MCA with fuzzy k-means simultaneously to classify a subgroup of observations and a subset of variable categories into a common cluster, while allowing both observations and variable categories to belong partially to multiple clusters. Importantly, we adopt regularized fuzzy k-means, thereby enabling us to decide the degree of fuzziness in cluster memberships automatically. We evaluate the performance of the proposed approach through the analysis of simulated and real data, in comparison with existing two-way clustering approaches.

  5. Fluid/Gravity Correspondence, Second Order Transport and Gravitational Anomaly***

    Science.gov (United States)

    Megías, Eugenio; Pena-Benitez, Francisco

    2014-03-01

    We study the transport properties of a relativistic fluid affected by chiral and gauge-gravitational anomalies. The computation is performed in the framework of the fluid/gravity correspondence for a 5 dim holographic model with Chern-Simons terms in the action. We find new anomalous and non anomalous transport coefficients, as well as new contributions to the existing ones coming from the mixed gauge-gravitational anomaly. Consequences for the shear waves dispersion relation are analyzed. Talk given by E. Megías at the International Nuclear Physics Conference INPC 2013, 2-7 June 2013, Firenze, Italy.Supported by Plan Nacional de Altas Energías (FPA2009-07908, FPA2011-25948), Spanish MICINN Consolider-Ingenio 2010 Programme CPAN (CSD2007-00042), Comunidad de Madrid HEP-HACOS S2009/ESP-1473, Spanish MINECO's Centro de Excelencia Severo Ochoa Program (SEV-2012-0234, SEV-2012-0249), and the Juan de la Cierva Program.

  6. Correspondência entre obesidade e hiperlipidemia em cães Correspondence between obesity and hyperlipidemia in dogs

    Directory of Open Access Journals (Sweden)

    Márcio Antonio Brunetto

    2011-02-01

    Full Text Available Os efeitos deletérios do excesso de peso sobre a saúde dos cães são bastante citados na literatura, mas pouco investigados. O termo hiperlipidemia refere-se ao aumento da concentração de lipídeos (colesterol, triglicérides ou ambos séricos. As desordens lipídicas são relativamente comuns nos cães e essas condições podem ocorrer como resultado de um defeito primário no metabolismo de lipoproteínas ou como consequência de doença sistêmica subjacente. O objetivo deste estudo foi avaliar a frequência de animais obesos que apresentam alterações nas concentrações de lipídios séricos e analisar a possível correspondência dessa condição com grau de obesidade, sexo, idade e castração. Foram incluídos 30 cães obesos com escore de condição corporal (ECC igual ou superior a 8 (em escala de um a nove, com nove representando obesidade acentuada e um grupo controle de dez animais com ECC igual a cinco. Nos animais com ECC 9 (n=21, foi encontrada frequência de 52,4% (n=11 de cães com hipercolesterolemia e 33,3% (n=7 com hipertrigliceridemia. Nos animais com EEC 8 (n=9, foi encontrada frequência de 22,2% (n=2 de hipercolesterolemia e de 33,3% (n=3 de hipertrigliceridemia. Essas alterações também apresentaram correspondência com o sexo feminino, faixa etária entre quatro e sete anos e a castração. Todavia, a elevação desses metabólitos foi moderada e não se situou em faixa de reconhecido risco à saúde.The harmful effects of obesity on dog health are quite mentioned in the literature, but little investigated. The term hyperlipidemia refers to the increase of lipid and/or fat concentration (cholesterol, triglycerides or both in serum. These disorders are relatively common in dogs and may happen as a result of a primary defect in metabolism of lipoproteins or as a consequence of a subjacent systemic disease. The aim of this study was to evaluate the frequency of obese dogs that present alterations on cholesterol

  7. The AdS/QCD correspondence: still undelivered

    International Nuclear Information System (INIS)

    Csaki, Csaba; Reece, Matthew; Terning, John

    2009-01-01

    We consider the particle spectrum and event shapes in large N gauge theories in different regimes of the short-distance 't Hooft coupling, λ. The mesons in the small λ limit should have a Regge spectrum in order to agree with perturbation theory, while generically the large λ theories with gravity duals produce spectra reminiscent of KK modes. We argue that these KK-like states are qualitatively different from QCD modes: they are deeply bound states which are sensitive to short distance interactions rather than the flux tube-like states expected in asymptotically free, confining gauge theories. In addition, we also find that the characteristic event shapes for the large λ theories with gravity duals are close to spherical, very different from QCD-like (small λ, small N) and Nambu-Goto-like (small λ, large N) theories which have jets. This observation is in agreement with the conjecture of Strassler on event shapes in large 't Hooft coupling theories, which was recently proved by Hofman and Maldacena for the conformal case. This conclusion does not change even when considering soft-wall backgrounds for the gravity dual. The picture that emerges is the following: theories with small and large λ are qualitatively different, while theories with small and large N are qualitatively similar. Thus it seems that it is the relative smallness of the 't Hooft coupling in QCD that prevents a reliable AdS/QCD correspondence from emerging, and that reproducing characteristic QCD-like behavior will require genuine stringy dynamics to be incorporated into any putative dual theory.

  8. The Compton-Schwarzschild correspondence from extended de Broglie relations

    Energy Technology Data Exchange (ETDEWEB)

    Lake, Matthew J. [The Institute for Fundamental Study, “The Tah Poe Academia Institute' ,Naresuan University, Phitsanulok 65000 (Thailand); Thailand Center of Excellence in Physics, Ministry of Education,Bangkok 10400 (Thailand); Carr, Bernard [School of Physics and Astronomy, Queen Mary University of London,Mile End Road, London E1 4NS (United Kingdom)

    2015-11-17

    The Compton wavelength gives the minimum radius within which the mass of a particle may be localized due to quantum effects, while the Schwarzschild radius gives the maximum radius within which the mass of a black hole may be localized due to classial gravity. In a mass-radius diagram, the two lines intersect near the Planck point (l{sub P},m{sub P}), where quantum gravity effects become significant. Since canonical (non-gravitational) quantum mechanics is based on the concept of wave-particle duality, encapsulated in the de Broglie relations, these relations should break down near (l{sub P},m{sub P}). It is unclear what physical interpretation can be given to quantum particles with energy E≫m{sub P}c{sup 2}, since they correspond to wavelengths λ≪l{sub P} or time periods τ≪t{sub P} in the standard theory. We therefore propose a correction to the standard de Broglie relations, which gives rise to a modified Schrödinger equation and a modified expression for the Compton wavelength, which may be extended into the region E≫m{sub P}c{sup 2}. For the proposed modification, we recover the expression for the Schwarzschild radius for E≫m{sub P}c{sup 2} and the usual Compton formula for E≪m{sub P}c{sup 2}. The sign of the inequality obtained from the uncertainty principle reverses at m≈m{sub P}, so that the Compton wavelength and event horizon size may be interpreted as minimum and maximum radii, respectively. We interpret the additional terms in the modified de Broglie relations as representing the self-gravitation of the wave packet.

  9. Lanthanum deposition corresponds to white lesions in the stomach.

    Science.gov (United States)

    Iwamuro, Masaya; Urata, Haruo; Tanaka, Takehiro; Kawano, Seiji; Kawahara, Yoshiro; Kimoto, Katsuhiko; Okada, Hiroyuki

    2018-05-23

    Although lanthanum deposition in the stomach has been most frequently reported to occur as white lesions, no study has investigated whether the white lesions observed during esophagogastroduodenoscopy are truly lanthanum-related. Here, we retrospectively investigated the amount of lanthanum in endoscopic biopsy specimens. We reviewed four patients showing gastric white spots or annular whitish mucosa in the gastric white lesions (Bw) and peripheral mucosa where the white substance was not endoscopically observed (Bp) during biopsy. We also reviewed three patients with diffuse whitish mucosa and three patients with no whitish lesions. We performed scanning electron microscopy and energy dispersive X-ray spectrometry to quantify the lanthanum elements (wt%) in the biopsy specimens. The amount of lanthanum in the Bw ranged from 0.15-0.31 wt%, whereas that of Bp was 0.00-0.13 wt%. The difference was statistically significant (P < 0.05). The amount of lanthanum in the Bw, endoscopically presented with white spots or annular whitish mucosa, was significantly higher than that of no whitish lesions (0.05-0.14 wt%, P < 0.05). The amount of lanthanum was also higher in the diffuse whitish mucosa (0.21-0.23 wt%) compared with no whitish lesions (P < 0.01). This study is the first to reveal that pathological lanthanum deposition corresponds to the endoscopically observed white lesions in the gastric mucosa. Therefore, during esophagogastroduodenoscopy, physicians should pay attention to possible presence of white lesions in patients treated with oral lanthanum carbonate to ensure prompt identification of associated issues. Copyright © 2018 Elsevier GmbH. All rights reserved.

  10. Is Bumblebee Foraging Efficiency Mediated by Morphological Correspondence to Flowers?

    Directory of Open Access Journals (Sweden)

    Ikumi Dohzono

    2011-01-01

    Full Text Available Preference for certain types of flowers in bee species may be an adaptation for efficient foraging, and they often prefer flowers whose shape fits their mouthparts. However, it is unclear whether such flowers are truly beneficial for them. We address this issue by experimentally measuring foraging efficiency of bumblebees, the volume of sucrose solution consumed over handling time (μL/second, using long-tongued Bombus diversus Smith and short-tongued B. honshuensis Tkalcu that visit Clematis stans Siebold et Zuccarini. The corolla tube length of C. stans decreases during a flowering period, and male flowers are longer than female flowers. Long- and short-tongued bumblebees frequently visited longer and shorter flowers, respectively. Based on these preferences, we hypothesized that bumblebee foraging efficiency is higher when visiting flowers that show a good morphological fit between the proboscis and the corolla tube. Foraging efficiency of bumblebees was estimated using flowers for which nectar quality and quantity were controlled, in an experimental enclosure. We show that 1 the foraging efficiency of B. diversus was enhanced when visiting younger, longer flowers, and that 2 the foraging efficiency of B. honshuensis was higher when visiting shorter female flowers. This suggests that morphological correspondence between insects and flowers is important for insect foraging efficiency. However, in contradiction to our prediction, 3 short-tongued bumblebees B. honshuensis sucked nectar more efficiently when visiting younger, longer flowers, and 4 there was no significant difference in the foraging efficiency of B. diversus between flower sexes. These results suggest that morphological fit between the proboscis and the corolla tube is not a sole determinant of foraging efficiency. Bumblebees may adjust their sucking behavior in response to available rewards, and competition over rewards between bumblebee species might change visitation patterns

  11. The ADS/QCD correspondence and exclusive processes

    International Nuclear Information System (INIS)

    Brodsky, Stanley J.; De Teramond, Guy F.; Deur, Alexandre

    2011-01-01

    The AdS/CFT correspondence between theories in AdS space and conformal field theories in physical space-time provides an analytic, semi-classical, color-confining model for strongly-coupled QCD. The soft-wall AdS/QCD model, modified by a positive-sign dilaton metric, leads to a remarkable one-parameter description of nonperturbative hadron dynamics at zero quark mass, including a zero-mass pion and meson and baryon Regge spectra of linear trajectories with the same slope in orbital angular momentum L and radial quantum number n. One also predicts the form of the non-perturbative effective coupling alpha AdS/s (Q) and its Beta-function which agrees with the effective coupling alphag1 extracted from the Bjorken sum rule. Light-front holography, which connects the fifth-dimensional coordinate of AdS space z to an invariant impact separation variable zeta, allows one to compute the analytic form of the frame-independent light-front wave functions, the fundamental entities which encode hadron properties as well as decay constants, form factors, deeply-virtual Compton scattering, exclusive heavy hadron decays, and other exclusive scattering amplitudes. One thus obtains a relativistic description of hadrons in QCD at the amplitude level with dimensional counting for exclusive reactions at high momentum transfer. As specific examples, we discuss the behavior of the pion and nucleon form factors in the space-like and time-like regions. We also review the phenomenology of exclusive processes including some anomalous empirical results.

  12. The AdS/QCD Correspondence and Exclusive Processes

    International Nuclear Information System (INIS)

    Brodsky, Stanley

    2010-01-01

    The AdS/CFT correspondence between theories in AdS space and conformal field theories in physical space-time provides an analytic, semi-classical, color-confining model for strongly-coupled QCD. The soft-wall AdS/QCD model modified by a positive-sign dilaton metric leads to a remarkable one-parameter description of nonperturbative hadron dynamics at zero quark mass, including a zero-mass pion and a Regge spectrum of linear trajectories with the same slope in orbital angular momentum L and radial quantum number n for both mesons and baryons. One also predicts the form of the non-perturbative effective coupling α s AdS (q) and its β-function which agrees with the effective coupling α ga extracted from the Bjorken sum rule. Light-front holography, which connects the fifth-dimensional coordinate of AdS space z to an invariant impact separation variable ζ, allows one to compute the analytic form of the frame-independent light-front wavefunctions, the fundamental entities which encode hadron properties as well as decay constants, form factors, deeply virtual Compton scattering, exclusive heavy hadron decays and other exclusive scattering amplitudes. One thus obtains a relativistic description of hadrons in QCD at the amplitude level with dimensional counting for hard exclusive reactions at high momentum transfer. As specific examples we discuss the behavior of the pion and nucleon form factors in the space-like and time-like regions. We also review the phenomenology of exclusive processes including some anomalous empirical results.

  13. Language Training - English Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional English Courses The next session will take place: from 2nd March to end of June 2009 (1/2 weeks break at Easter). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Nathalie Dumeaux, tel. 78144. Oral Expression The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be an average of 8 participants per class. Speaking activities will include discussions, meeting simulations, role-plays, etc., depending on the needs of the students. Duration: 30 hours Price: 660 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is designed for people ...

  14. Language Training - English Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional English Courses The next session will take place: from 2nd March to end of June 2009 (1/2 weeks break at Easter). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Nathalie Dumeaux, tel. 78144. Oral Expression The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be on average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 30 hours Price: 660 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is designed for people w...

  15. [A follow-up study on a randomized, single-blind control of King's Brain pills in treatment of memory disorder in elderly people with MCI in a Beijing community].

    Science.gov (United States)

    Tian, Jin-zhou; Zhu, Ai-hua; Zhong, Jian

    2003-10-01

    To evaluate the effect of King's Brain pills (Compound Chinese ginseng extract from herbs) on the treatment and the delaying of memory decline in the elderly with mild cognitive impairment (MCI) in a community by a year follow-up of neuropsychology. 75 patients with MCI were selected from Beixinqiao community of Beijing by a cutoff score of 0.0/0.5 on CDR and were randomly assigned into a treatment group (n = 30 cases), given 4 pills of a compound Chinese ginseng extract (King's Brain) with 2 placebo tablets, and a positive control group (n = 30 cases), given 2 tablets of Piracetam with 4 placebo tablets, as well as a placebo group (n = 15 cases), given a placebo of 4 tablets and 2 pills. All subjects took this medication 3 times a day for 3 months. Single-blind and double-moulding control were used in this study. At a baseline and a middlepoint (after 3 months), and a follow-up end (one year later) following a three months of medication therapeutics, all subjects were assessed using a battery consisting of MMSE and 5 memory items on BNPT battery. In the treatment group, MMSE score 27.50 +/- 1.68 was increased to 28.27 +/- 1.70 after 3 months but decreased to 26.90 +/- 1.90 after one year of the treatment. However, the latter score was higher than that in a placebo group 26.33 +/- 1.03 (P Brain spills and piracetam tablets have protective effect on cognitive and memory decline in elderly with MCI.

  16. Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial.

    Science.gov (United States)

    Han, Ji Won; Son, Kyung Lak; Byun, Hye Jin; Ko, Ji Won; Kim, Kayoung; Hong, Jong Woo; Kim, Tae Hyun; Kim, Ki Woong

    2017-06-06

    Spaced retrieval training (SRT) is a nonpharmacological intervention for mild cognitive impairment (MCI) and dementia that trains the learning and retention of target information by recalling it over increasingly long intervals. We recently developed the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program as a convenient, self-administered tablet-based SRT program. We also demonstrated the utility of USMART for improving memory in individuals with MCI through an open-label uncontrolled trial. This study had an open-label, single-blind, randomized, controlled, two-period crossover design. Fifty patients with MCI were randomized into USMART-usual care and usual care-USMART treatment sequences. USMART was completed or usual care was provided biweekly over a 4-week treatment period with a 2-week washout period between treatment periods. Primary outcome measures included the Word List Memory Test, Word List Recall Test (WLRT), and Word List Recognition Test. Outcomes were measured at baseline, week 5, and week 11 by raters who were blinded to intervention type. An intention-to-treat analysis and linear mixed modeling were used. Of 50 randomized participants, 41 completed the study (18% dropout rate). The USMART group had larger improvements in WLRT score (effect size = 0.49, p = 0.031) than the usual care group. There were no significant differences in other primary or secondary measures between the USMART and usual care groups. Moreover, no USMART-related adverse events were reported. The 4-week USMART modestly improved information retrieval in older people with MCI, and was well accepted with minimal technical support. ClinicalTrials.gov NCT01688128 . Registered 12 September 2012.

  17. Quantum-Classical Correspondence: Dynamical Quantization and the Classical Limit

    International Nuclear Information System (INIS)

    Turner, L

    2004-01-01

    In only 150 pages, not counting appendices, references, or the index, this book is one author's perspective of the massive theoretical and philosophical hurdles in the no-man's-land separating the classical and quantum domains of physics. It ends with him emphasizing his own theoretical contribution to this area. In his own words, he has attempted to answer: 1. How can we obtain the quantum dynamics of open systems initially described by the equations of motion of classical physics (quantization process) 2. How can we retrieve classical dynamics from the quantum mechanical equations of motion by means of a classical limiting process (dequantization process). However, this monograph seems overly ambitious. Although the publisher's description refers to this book as an accessible entre, we find that this author scrambles too hastily over the peaks of information that are contained in his large collection of 272 references. Introductory motivating discussions are lacking. Profound ideas are glossed over superficially and shoddily. Equations morph. But no new convincing understanding of the physical world results. The author takes the viewpoint that physical systems are always in interaction with their environment and are thus not isolated and, therefore, not Hamiltonian. This impels him to produce a method of quantization of these stochastic systems without the need of a Hamiltonian. He also has interest in obtaining the classical limit of the quantized results. However, this reviewer does not understand why one needs to consider open systems to understand quantum-classical correspondence. The author demonstrates his method using various examples of the Smoluchowski form of the Fokker--Planck equation. He then renders these equations in a Wigner representation, uses what he terms an infinitesimality condition, and associates with a constant having the dimensions of an action. He thereby claims to develop master equations, such as the Caldeira-Leggett equation, without

  18. Instructor training

    International Nuclear Information System (INIS)

    Yuzhakov, A.Yu.

    1995-01-01

    A SAT-based Instructor Training Course was developed and implemented at NVTC. The duration of the initial course is 3 weeks and 2 weeks for annual refresher course. NVTC has had much experience with this Instructor Training Course generating the following lessons-learned: SAT implementation needs to be supported by plant management; age of instructors; developments of training materials and conducting training at the same time; knowledge and use of the PC; English language skills; social transitioning from the NPP to the TC; motivation; workplace environment and conditions

  19. 19 CFR 145.3 - Opening of letter class mail; reading of correspondence prohibited.

    Science.gov (United States)

    2010-04-01

    ... correspondence. The provisions of paragraph (c) shall also apply to correspondence between school children and correspondence of the blind which are authorized to be mailed at other than the letter rate of postage in...

  20. Effects of Refresher Training on Job-Task Typewriting Performance.

    Science.gov (United States)

    Hagman, Joseph D.; Schendel, Joel D.

    Two groups of 15 Administrative Specialists, 7lL Military Occupational Speciality (MOS), participated in four job-task refresher training sessions designed to enhance the typewriting of military correspondence. One group performed under a study training method which allowed use of a Correspondence Manual while arranging materials into the correct…

  1. Ketogenic diet, high intensity interval training (HIIT) and memory training in the treatment of mild cognitive impairment: A case study.

    Science.gov (United States)

    Dahlgren, Kaitlyn; Gibas, Kelly J

    2018-04-11

    Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise. Ketones are neuroprotective agents that shelter the aging brain from memory loss and neurodegeneration. Induced ketone production has been shown to ameliorate mitochondrial function, reduce the expression of apoptotic and inflammatory mediators and provide neuroprotection to cells (Lange et al., 2017). This case study highlights an innovative research design aimed at attenuating memory decline in a 57 year old female previously diagnosed with comorbid mild cognitive impairment (MCI) and metabolic syndrome (MetS). Mild cognitive impairment is a predementia syndrome known to precede AD (Michaud et al, 2017). The 12-week intervention included ketogenic nutrition protocol, high intensity interval training (HIIT) and memory training using the PEAK brain training app. Memory function was assessed via the MoCA (Montreal Cognitive Assessment) pre/post intervention. Physiological biomarkers for MetS including HOMA-IR(homeostatic model assessment of insulin resistance), triglyceride/HDL ratio, HgA1c, fasting triglycerides and HDL were measured pre/post intervention. MoCA baseline score was 22/30 (MCI); post intervention score: 30/30 (normal). MetS biomarker improvements also reflected statistical significance. Copyright © 2018. Published by Elsevier Ltd.

  2. Field training

    International Nuclear Information System (INIS)

    Mumford, G.E.; Hadaway, E.H.

    1991-01-01

    Individualized, personal training can be used to increase an employee's awareness of the HSE program. Such training can stimulate personal commitment and provide personal skills that can be utilized for the benefit of the overall HSE effort. But, providing such training within our industry can be a difficult task due to the scheduling, travel arrangements, and cost associated with bringing employees from isolated, remote locations to centrally located training facilities. One method of overcoming these obstacles involves the use of field instructors to provide the training at the many, and varied number of individuals can be reached with minimal disruption to their work scheduling or to their time off. In fact, this type of on-site training is already used by some oil companies and drilling contractors with encouraging results. This paper describes one drilling contractor's experiences with such a training program. The results after eight years how that this program not only can provide and efficient, economical means of employee training, but also can have a direct application to employee motivation regarding a company's HSE effort

  3. [Teacher Training.

    Science.gov (United States)

    Palmatier, Robert A., Ed.

    1977-01-01

    This issue collects three articles concerning reading-teacher training. "Language, Failure, and Panda Bears" by Patricia M. Cunningham calls attention to dialect difficulties in the classroom and provides ideas for teacher training programs and for public schools to solve this problem. William H. Rupley, in "Improving Teacher Effectiveness in…

  4. ENGLISH TRAINING

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch PLACES AVAILABLE Writing Professional Documents in English This course is designed for people with a good level of spoken English who need to improve their professional writing (administrative, scientific, technical). Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) Date and timetable will be fixed when there are sufficient participants enrolled. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their sp...

  5. Operator training

    International Nuclear Information System (INIS)

    Wirstad, J.

    1983-12-01

    The traditional operator job is changing, which among other things has generated a need for better job training. Surprisingly increased process automation has lead to increased operator qualifications, i.e. basic job training but also up-date and rehearsal training within certain fixed intervals. There are several, similar models for instructional system development available in the literature. One model which is of special interest integrates Operator Training development and Man-Machine Interfaces development. The extent to which Systematic Operator Training has been implemented varies with branches and companies. The nuclear power branch is given as an example in the report. This branch probably represents something better than the average among the process industries.(author)

  6. Training Standardization

    International Nuclear Information System (INIS)

    Agnihotri, Newal

    2003-01-01

    The article describes the benefits of and required process and recommendations for implementing the standardization of training in the nuclear power industry in the United States and abroad. Current Information and Communication Technologies (ICT) enable training standardization in the nuclear power industry. The delivery of training through the Internet, Intranet and video over IP will facilitate this standardization and bring multiple benefits to the nuclear power industry worldwide. As the amount of available qualified and experienced professionals decreases because of retirements and fewer nuclear engineering institutions, standardized training will help increase the number of available professionals in the industry. Technology will make it possible to use the experience of retired professionals who may be interested in working part-time from a remote location. Well-planned standardized training will prevent a fragmented approach among utilities, and it will save the industry considerable resources in the long run. It will also ensure cost-effective and safe nuclear power plant operation

  7. Neurochemical and Neuroanatomical Plasticity Following Memory Training and Yoga Interventions in Older Adults with Mild Cognitive Impairment.

    Science.gov (United States)

    Yang, Hongyu; Leaver, Amber M; Siddarth, Prabha; Paholpak, Pattharee; Ercoli, Linda; St Cyr, Natalie M; Eyre, Harris A; Narr, Katherine L; Khalsa, Dharma S; Lavretsky, Helen

    2016-01-01

    Behavioral interventions are becoming increasingly popular approaches to ameliorate age-related cognitive decline, but their underlying neurobiological mechanisms and clinical efficiency have not been fully elucidated. The present study explored brain plasticity associated with two behavioral interventions, memory enhancement training (MET) and a mind-body practice (yogic meditation), in healthy seniors with mild cognitive impairment (MCI) using structural magnetic resonance imaging (s-MRI) and proton magnetic resonance spectroscopy ( 1 H-MRS). Senior participants (age ≥55 years) with MCI were randomized to the MET or yogic meditation interventions. For both interventions, participants completed either MET training or Kundalini Yoga (KY) for 60-min sessions over 12 weeks, with 12-min daily homework assignments. Gray matter volume and metabolite concentrations in the dorsal anterior cingulate cortex (dACC) and bilateral hippocampus were measured by structural MRI and 1 H-MRS at baseline and after 12 weeks of training. Metabolites measured included glutamate-glutamine (Glx), choline-containing compounds (Cho, including glycerophosphocholine and phosphocholine), gamma-aminobutyric acid (GABA), and N-acetyl aspartate and N-acetylaspartyl-glutamate (NAA-NAAG). In total, 11 participants completed MET and 14 completed yogic meditation for this study. Structural MRI analysis showed an interaction between time and group in dACC, indicating a trend towards increased gray matter volume after the MET intervention. 1 H-MRS analysis showed an interaction between time and group in choline-containing compounds in bilateral hippocampus, induced by significant decreases after the MET intervention. Though preliminary, our results suggest that memory training induces structural and neurochemical plasticity in seniors with MCI. Further research is needed to determine whether mind-body interventions like yoga yield similar neuroplastic changes.

  8. Relative Intensity Influences the Degree of Correspondence of Jump Squats and Push Jerks to Countermovement Jumps.

    Science.gov (United States)

    Cushion, Emily J; Goodwin, Jon E; Cleather, Daniel J

    2016-05-01

    The aim of this study was to determine the mechanical similarity between push jerk (PJ) and jump squat (JS) to countermovement jump (CMJ) and further understand the effect increasing external load may have on this relationship. Eight physically trained men (age 22 ± 3; height 176 ± 7 kg; weight 83 ± 8 kg) performed an unloaded CMJ followed by JS under a range of loads (10, 25, 35, and 50% 1RM back squat) and PJ (30, 50, 65, and 75% 1RM push jerk). A portable force platform and high-speed camera both collecting at 250 Hz were used to establish joint moments and impulse during the propulsive phase of the movements. A standard inverse dynamics model was used to determine joint moment and impulse at the hip, knee, and ankle. Significant correlations (p ≤ 0.05) were shown between CMJ knee joint moment and JS knee joint moment at 25% load and PJ knee joint moment at 30 and 50% load. Significant correlations were also observed between CMJ knee joint impulse and JS knee joint impulse at 10% load and PJ knee joint moment at 30 and 65% load. Significant correlation was also observed between CMJ hip joint impulse and PJ hip joint impulse at 30% load. No significant joint × load interaction was shown as load increased for either PJ or JS. Results from the study suggest partial correspondence between PJ and JS to CMJ, where a greater mechanical similarity was observed between the PJ and CMJ. This interaction is load and joint dependent where lower relative loads showed greatest mechanical similarity. Therefore using lower relative loads when programming may provide a greater transfer of training effect.

  9. Training Attestations

    CERN Multimedia

    HR Department

    2004-01-01

    In the past, paper Training Attestations were printed during the first quarter of a New Year for Staff Members having followed courses and seminars the previous year in the context of CERN's official Training Programmes.  The attestations were sent to Divisional Training Officers (DTO's) for distribution to all Staff Members concerned within their Division. In practise many Staff Members did not find this paper useful, however some expressed a wish to be able to have access to a self-service facility in case of need. This change was discussed by the Joint Training Board (JTB) and with the DTO's during 2003 and was supported. As a consequence, following a collaboration between HR-PMD and IT-AIS, from 2004 onwards paper Training Attestations will no longer be printed and distributed as before. Those requiring a list of training followed in the past can now obtain their attestation directly from the Human Resources Toolkit (HRT) application for all training followed since 1997. https://hrt.cern...

  10. LANGUAGE TRAINING

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch FRENCH TRAINING General and Professional French Courses The next session will take place from 26 January to 02 April 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 January to 02 April 2004. This course is designed for people wi...

  11. LANGUAGE TRAINING

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch FRENCH TRAINING General and Professional French Courses The next session will take place from 26 January to 02 April 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz : Tel. 73127. Writing Professional Documents in French The next session will take place from 26 January to 02 April 2004. This course is designed for peop...

  12. 37 CFR 1.33 - Correspondence respecting patent applications, reexamination proceedings, and other proceedings.

    Science.gov (United States)

    2010-07-01

    ... otherwise make available, all notices, official letters, and other communications relating to the... with a Customer Number over a typed correspondence address. For the party to whom correspondence is to... be changed by any party who may change the correspondence address. The correspondence address may be...

  13. Driverless Train

    OpenAIRE

    Törnqvist, Julia; Berglund, Emma

    2017-01-01

    As automation increases in train services, this project resulted in making a driver-less train. The main purpose was to see how security can be increased. By using sensors, today’s technologies and rebuild the stations with walls on the platforms, the safety can increase for the better. This project designs a railway system consisting of a train, boom barriers and a station. The mechanical parts were made from scratch to get the system to work beneficially. The use of Arduino as a micro contro...

  14. Enhancing Performance Under Stress: Stress Inoculation Training for Battlefield Airmen

    Science.gov (United States)

    2014-01-01

    activi- ties, email correspondence with AETC subject matter experts identified safety issues concern- ing the current facility’s lack of capacity and...on-requests in follow-on BUD/S training. Provide a Water Training Facility for Pararescue and Combat Control Training Email correspondence with AETC...ammunition; multitask loading; and reduced resources such as minimal cover in a firefight and having to use a weapon that had been rigged to misfire

  15. Attributing Authorship in the Noisy Digitized Correspondence of Jacob and Wilhelm Grimm

    Directory of Open Access Journals (Sweden)

    Greta Franzini

    2018-04-01

    Full Text Available This article presents the results of a multidisciplinary project aimed at better understanding the impact of different digitization strategies in computational text analysis. More specifically, it describes an effort to automatically discern the authorship of Jacob and Wilhelm Grimm in a body of uncorrected correspondence processed by HTR (Handwritten Text Recognition and OCR (Optical Character Recognition, reporting on the effect this noise has on the analyses necessary to computationally identify the different writing style of the two brothers. In summary, our findings show that OCR digitization serves as a reliable proxy for the more painstaking process of manual digitization, at least when it comes to authorship attribution. Our results suggest that attribution is viable even when using training and test sets from different digitization pipelines. With regards to HTR, this research demonstrates that even though automated transcription significantly increases the risk of text misclassification when compared to OCR, a cleanliness above ≈ 20% is already sufficient to achieve a higher-than-chance probability of correct binary attribution.

  16. Study of radon-222 emanation from sedimentary phosphates and corresponding phosphogypsum. Temperature effect

    International Nuclear Information System (INIS)

    Boujrhal, F.M.

    1993-01-01

    The aim of this study is to examine the effect of temperature on radon emanation from the phosphates of various regions of Morocco, from corresponding phosphogypsum and from teeth fossilized of Youssoufia phosphate. The interpretation of obtained results was carried out by the physicochemical studies with various approaches; the X-ray diffraction analysis, the measurement of the specific surface area and porousness, the determination of the oxygen content by activation analysis with 14 MeV neutron. The thermal treatment between 100 and 900 degrees C conducted to the following points: - An increase of the radon degassing rate, which is first slow when the temperature increase from 20 to 600 degrees C, then becomes brutal beyond this temperature. We attributed this variation to the training effect ( transport effect ) of radon by the others gas susceptible to be released with thermal effect, particularly the CO sub 2. - The reduction of the radon emanation power versus temperature. We could demonstrate a linear correlation between the power emanation and the specific surface area. 122 refs., 102 figs., 20 tabs. (Author)

  17. Resuscitation training.

    OpenAIRE

    Shepherd, A.

    1995-01-01

    All physicians, dentists, nurses and health care personnel should be adequately and regularly trained in cardiopulmonary resuscitation. Guidelines for acquiring the necessary skills in basic and advanced life support are now available.

  18. Interval Training

    Science.gov (United States)

    ... you're overdoing it, slow down. As your stamina improves, challenge yourself to vary the pace. You ... exercise training modes in young and old humans. Cell Metabolism. 2017;25:581. Xie B, et al. ...

  19. Personnel Training

    International Nuclear Information System (INIS)

    Tokar, M.

    2012-01-01

    The professional training of employees for Units 3 and 4 of the Mochovce Power Plant is approaching finals. At the beginning, in particular the main control room operators were trained, later all the other employees needed for power plant commissioning and operation. In June, the second phase of the project will start; it will be focused on the new equipment of the Units under commissioning. (author)

  20. Supervisor training

    DEFF Research Database (Denmark)

    Pedersen, Inge Nygaard

    2015-01-01

    on the experience of an integrated supervisor training programme offered in Aalborg, Denmark in 2009/2010. In this programme general issues of professional supervision and the application of artistic media as a core element in the supervisory process were Integrated. It is the hope of the author that this article...... will inspire other music therapists to develop supervisor training programmes for professional music therapists and also to undertake further research into professional supervision....

  1. Activities, postures and comfort perception of train passengers as input for train seat design

    NARCIS (Netherlands)

    Groenesteijn, L.; Hiemstra-van Mastrigt, S.; Gallais, C.; Blok, M.; Kuijt-Evers, L.; Vink, P.

    2014-01-01

    Working in the train is a part of new ways of working. However, the ideal working position is unknown. Moreover, the ideal position for leisure and relaxing is also unknown. This article defines what activities train passengers mainly perform and which corresponding postures are seen. Based on the

  2. Study on solid phase extraction and graphite furnace atomic absorption spectrometry for the determination of nickel, silver, cobalt, copper, cadmium and lead with MCI GEL CHP 20Y as sorbent

    International Nuclear Information System (INIS)

    Yang Guangyu; Fen Weibo; Lei Chun; Xiao Weilie; Sun Handong

    2009-01-01

    A solid phase extraction and graphite furnace atomic absorption spectrometry (GFAAS) for the determination of nickel, silver, cobalt, copper, cadmium and lead with MCI GEL CHP 20Y as sorbent was studied. Trace amounts of chromium, nickel, silver, cobalt, copper, cadmium and lead were reacted with 2-(2-quinolinil-azo)-4-methyl-1,3-dihydroxidobenzene (QAMDHB) followed by adsorption onto MCI GEL CHP 20Y solid phase extraction column, and 1.0 mol L -1 HNO 3 was used as eluent. The metal ions in 300 mL solution can be concentrated to 1.0 mL, representing an enrichment factor of 300 was achieved. The recoveries of analytes at pH 8.0 with 1.0 g of resin were greater than 95% without interference from alkaline, earth alkaline and some metal ions. When detected with graphite furnace atomic absorption spectrometry, the detection limits in the original samples were 1.4 ng L -1 for Cr(III), 1.0 ng L -1 for Ni(II), 0.85 ng L -1 for Ag(I), 1.2 ng L -1 for Co(II), 1.0 ng L -1 for Cu(II), 1.2 ng L -1 for Cd(II) and 1.3 ng L -1 for Pb(II). The validation of the procedure was performed by the analysis of the certified standard reference materials, and the presented procedure was applied to the determination of analytes in biological, water and soil samples with good results (recoveries range from 89 to 104%, and R.S.D.% lower than 3.2%. The results agreed with the standard value or reference method)

  3. Training Relations

    DEFF Research Database (Denmark)

    Smith, Aja

    This thesis explores the phenomenon of horse-assisted leadership training and the manners, in which the training relations between horses, managers and facilitators were entangled with perceptions of, what “proper sociality” entailed and felt like in contemporary Danish society. The study...... is positioned at the intersection of anthropology and consumer culture research and is based upon 15 months of ethnographic fieldwork in fields, offices and conference rooms throughout Denmark in 2012 and 2013 as well as reading of emic literature and marketing material. The main argument of the thesis is...

  4. French Training

    CERN Multimedia

    Françoise Benz

    2003-01-01

    General and Professional French Courses The next session will take place: from 13 October to 19 December 2003. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages or contact Mrs. Fontbonne: Tel. 72844. Writing Professional Documents in French This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF (for 8 students) For further information and registration, please consult our Web pages or contact Mrs. Fontbonne: Tel. 72844. Language Training Françoise Benz Tel.73127 language.training@cern.ch

  5. Association of Fellowship Training With Otolaryngology Training Examination Scores.

    Science.gov (United States)

    Akinboyewa, Ibukun; Cabrera-Muffly, Cristina

    2016-03-01

    No prior studies have evaluated whether residents who pursue fellowship training achieve higher performance on the Otolaryngology Training Examination (OTE) and whether a specific fellowship will demonstrate a correlation with the corresponding specialty-specific OTE score. To determine whether residents pursuing fellowship training achieve higher performance on the OTE and whether fellowship choice is correlated with higher scores on the related subspecialty section of the OTE. This retrospective analysis included 35 residents training in an academic otolaryngology residency program from July 1, 2003, to June 30, 2014. The OTE scores for postgraduate years 2 through 5 and the type of fellowship were collected for all residents meeting inclusion criteria. Data were collected from September 1 to October 15, 2014, and analyzed from October 16 to December 1, 2014. Residents were divided by whether they pursued fellowship training and by the type of fellowship chosen. Outcome measures included comparison of scores between residents who pursued vs those who did not pursue fellowship training and comparison of subspecialty OTE scores between residents who pursued the corresponding fellowship and those who did not. Of the 35 residents who met the inclusion criteria (24 men and 11 women), 17 (49%) pursued fellowship training. The 3 most common fellowship choices were facial plastic and reconstructive surgery, pediatric otolaryngology, and rhinology (4 residents each [24%]). For all residents, mean scores on the OTE improved each subsequent training year, but this difference was only significant between postgraduate years 2 and 3 (from 60.9% to 68.6% correct; P otolaryngology, 72.9% vs 71.3% [P = .79]; and for rhinology, 72.2% vs 71.2% [P = .91]). Residents who pursued fellowship training did not achieve higher scores on the OTE in any examination year compared with residents who did not pursue fellowship training and did not achieve higher scores within the OTE

  6. 14 CFR 25.29 - Empty weight and corresponding center of gravity.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Empty weight and corresponding center of gravity. 25.29 Section 25.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... and corresponding center of gravity. (a) The empty weight and corresponding center of gravity must be...

  7. 14 CFR 29.29 - Empty weight and corresponding center of gravity.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Empty weight and corresponding center of gravity. 29.29 Section 29.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... weight and corresponding center of gravity. (a) The empty weight and corresponding center of gravity must...

  8. 14 CFR 27.29 - Empty weight and corresponding center of gravity.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Empty weight and corresponding center of gravity. 27.29 Section 27.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... and corresponding center of gravity. (a) The empty weight and corresponding center of gravity must be...

  9. 37 CFR 1.4 - Nature of correspondence and signature requirements.

    Science.gov (United States)

    2010-07-01

    ... signature requirements. 1.4 Section 1.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND... General Information and Correspondence § 1.4 Nature of correspondence and signature requirements. (a...) Handwritten signature. Each piece of correspondence, except as provided in paragraphs (d)(2), (d)(3), (e) and...

  10. ACADEMIC TRAINING

    CERN Multimedia

    Françoise Benz

    2002-01-01

    12, 13, 14, March LECTURE SERIES from 11.00 to 12.00 hrs - Auditorium, bldg. 500 POSTPONED! - Modern Project Management Methods - POSTPONED! By G. Vallet / Ed. Highware, Paris, F. Academic Training Françoise Benz Secretariat Tel. 73127 francoise.benz@cern.ch

  11. Language Training

    CERN Multimedia

    Françoise Benz

    2005-01-01

    If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Departmental Secretariat or from your DTO (Departmental Training Officer). Applications will be accepted in the order in which they are received. General and Professional English Courses The next session will take place: from end of September 2005 to middle of February 2006 (2/ 3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957. Oral Expression The next session will take place from end of September to December 2005. This course is intended for people with a good knowledge of English who want to practise and maintain the...

  12. Language training

    CERN Document Server

    Françoise Benz

    2006-01-01

    If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training'form available from your Departmental Secretariat or from your DTO (Departmental Training Officer). Applications will be accepted in the order in which they are received. General and Professional English Courses The next session will take place from beginning of October 2006 to beginning of February 2007 (3 weeks break at Christmas).These courses are open to all persons working on the CERN site and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Tessa Osborne, tel.16 23 40. Oral Expression The next session will take place from beginning of October 2006 to beginning of February 2007 (3 weeks break at Christmas).This course is intended for people with a goo...

  13. Language training

    CERN Multimedia

    2006-01-01

    If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Departmental Secretariat or from your DTO (Departmental Training Officer). Applications will be accepted in the order in which they are received. General and Professional English Courses The next session will take place from beginning of October 2006 to beginning of February 2007 (3 weeks break at Christmas).These courses are open to all persons working on the CERN site and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Tessa Osborne, tel.16 23 40. Oral Expression The next session will take place from beginning of October 2006 to beginning of February 2007 (3 weeks break at Christmas).This course is intended for people with a good knowl...

  14. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Monday 9 February 2004 From 10:00 to 12:00 - IT Auditorium - bldg. 31, 3rd floor ANSOFT High-Frequency Seminar David Prestaux, Application Engineer, ANSOFT F-78535 BUC, France This Technical Training seminar will present two Ansoft application products: Ansoft HFSS and Ansoft Designer. Ansoft HFSS makes use of the Finite Element Method (FEM) to calculate field solutions from first principles. It can accurately predict all high-frequency behaviours such as dispersion, mode conversion, and losses due to materials and radiation. Ansoft Designer is a suite of design tools to fully integrate high-frequency, physics-based electromagnetic simulations into a seamless system-level simulation environment. Ansoft Designer uses a simple interface to give complete control over every design task, by a method allowing multiple solvers, Solver on Demand. • Introduction • Overview of the Ansoft Total solution • Ansoft HFSS 9...

  15. Effects of corresponding and non-corresponding contaminants on the fate of sulfonamide and quinolone resistance genes in the Laizhou Bay, China.

    Science.gov (United States)

    Li, Qianwei; Na, Guangshui; Zhang, Linxiao; Lu, Zihao; Gao, Hui; Li, Ruijing; Jin, Shuaichen

    2018-03-01

    The environmental behaviors and migration patterns of antibiotic resistance genes (ARGs) have attracted considerable research interest. However, there has been little research concerning the effects of corresponding and non-corresponding contaminants on the fate of ARGs in coastal environments. In the present study, the distribution of intI1, sul1, sul2, qnrS and aac(6')-Ib were analyzed in water and sediment samples of Laizhou Bay in the context of corresponding and non-corresponding contaminants. The abundance of intI1, sul1 and sul2 genes exhibited a clear decreasing trend extending from the inner estuary to the coastal area. Strong and positive correlations existed between sul1/sul2 and sulfonamide antibiotic residues in sediments, and between the abundances of intI1 and sul1/sul2. Statistical analyses indicated that non-corresponding contaminants were partially correlated with ARG abundances. These results suggest that non-corresponding contaminants may have direct or indirect influences on the abundances of ARGs and intI1 in the Laizhou Bay. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. [Prevention of dyslexia – short-term and intermediate effects of promoting phonological awareness and letter-sound correspondence with at-risk preschool children].

    Science.gov (United States)

    Höse, Anna; Wyschkon, Anne; Moraske, Svenja; Eggeling, Marie; Quandte, Sabine; Kohn, Juliane; Poltz, Nadine; von Aster, Michael; Esser, Günter

    2016-09-01

    This study assesses the short-term and intermediate effects of preschool training stimulating phonological awareness and letter-sound correspondence for children at risk of developing dyslexia. Moreover, we examined whether training reduced the frequency of subsequent dyslexic problems. 25 children at risk of developing dyslexia were trained with Hören, Lauschen, Lernen 1 und 2 (Küspert & Schneider, 2008; Plume & Schneider, 2004) by their kindergarten teachers and were compared with 60 untrained at-risk children. The training revealed a significant short-term effect: The phonological awareness of trained at-risk children increased significantly over that of untrained at-risk children. However, there were no differences in phonological awareness, spelling, and reading ability between the first-graders in the training and control group. Furthermore, reading problems were reduced in the training group. In the future, phonological awareness as well as additional predictors should be included when identifying children vulnerable to developing dyslexia. Moreover, in order to prevent dyslexia, additional prerequisite deficits need to be identified, alleviated, and their effects evaluated.

  17. Effects of Aerobic Training on Cognition and Brain Glucose Metabolism in Subjects with Mild Cognitive Impairment.

    Science.gov (United States)

    Porto, Fábio Henrique de Gobbi; Coutinho, Artur Martins Novaes; Pinto, Ana Lucia de Sá; Gualano, Bruno; Duran, Fabio Luís de Souza; Prando, Silvana; Ono, Carla Rachel; Spíndola, Lívia; de Oliveira, Maira Okada; do Vale, Patrícia Helena Figuerêdo; Nitrini, Ricardo; Buchpiguel, Carlos Alberto; Brucki, Sonia Maria Dozzi

    2015-01-01

    Aerobic training (AT) is a promising intervention for mild cognitive impairment (MCI). To evaluate the effects of AT on cognition and regional brain glucose metabolism (rBGM) in MCI patients. Subjects performed a twice-a-week, moderate intensity, AT program for 24 weeks. Assessment with ADAS-cog, a comprehensive neuropsychological battery, and evaluation of rBGM with positron emission tomography with 18F-fluorodeoxyglucose ([18F]FDG-PET) were performed before and after the intervention. Aerobic capacity was compared using the maximal oxygen consumption VO2max (mL/Kg/min). [18F]FDG-PET data were analyzed on a voxel-by-voxel basis with SPM8 software. Forty subjects were included, with a mean (M) age of 70.3 (5.4) years and an initial Mini-Mental State Exam score of 27.4 (1.7). Comparisons using paired t-tests revealed improvements in the ADAS-cog (M difference: -2.7 (3.7), p <  0.001) and VO2max scores (M difference: 1.8 (2.0) mL/kg/min, p <  0.001). Brain metabolic analysis revealed a bilateral decrease in the rBGM of the dorsal anterior cingulate cortex, pFWE = 0.04. This rBGM decrease was negatively correlated with improvement in a visuospatial function/attentional test (rho =-0.31, p = 0.04). Several other brain areas also showed increases or decreases in rBGM. Of note, there was an increase in the retrosplenial cortex, an important node of the default mode network, that was negatively correlated with the metabolic decrease in the dorsal anterior cingulate cortex (r =-0.51, p = 0.001). AT improved cognition and changed rBGM in areas related to cognition in subjects with MCI.

  18. Sports Training

    Science.gov (United States)

    1988-01-01

    Practitioners of martial arts have long seen a need for a precise method of measuring the power of a karate kick or a boxer's punch in training and competition. Impax sensor is a piezoelectric film less than one thousandth of an inch thick, yet extremely durable. They give out a voltage impulse when struck, the greater the force of impact, the higher the voltage. The impulse is transmitted to a compact electronics package where voltage is translated into a force-pounds reading shown on a digital display. Impax, manufactured by Impulse Technology, Inc. is used by martial arts instructors, practitioners, U.S. Olympic Committee Training Center, football blocking sleds, and boxers as well as police defensive tactics, providing a means of evaluating the performance of recruits.

  19. Language Training

    CERN Multimedia

    HR Department

    Permanence A "permanence" for language Training has been set up. If anyone has a question or requires information on any aspect of English or French training please come to our office 5 4-016 at the following times. Lucette Fournier - French courses Monday 13.30 - 15.30 Tuesday\t10.30 - 12.30 Tessa Osborne - English courses Wednesday\t12.00 - 14.00 Thursday\t11.00 - 13.00   New courses Specific English and French courses - Exam preparation/ We are now offering specific courses in English and French leading to a recognised external examination (e.g. Cambridge, DELF, DALF). If you are interested in following one of these courses and have at least an upper intermediate level of English or French, please enrol through the following link:  English courses French courses Or contact: Tessa Osborne 72957 (English courses) Lucette Fournier 73483 (French courses) Language Training Nathalie Dumeaux Tel. 78144 nathalie.dumeaux@cern.ch

  20. Language Training

    CERN Multimedia

    HR Department

    2009-01-01

    PermanenceA "permanence" for language Training has been set up. If anyone has a question or requires information on any aspect of English or French training please come to our office 5 4-016 at the following times. Lucette Fournier French courses Monday 13.30 - 15.30 Tuesday\t10.30 - 12.30 Tessa Osborne English courses Wednesday\t12.00 - 14.00 Thursday\t11.00 - 13.00 New courses Specific English and French courses - Exam preparation/ We are now offering specific courses in English and French leading to a recognised external examination (e.g. Cambridge, DELF and BULATS). If you are interested in following one of these courses and have at least an upper intermediate level of English or French, please enrol through the following link: http://English courses http://French courses Or contact: Tessa Osborne 72957 (English courses) Lucette Fournier 73483 (French courses) Language Training Nathalie Dumeaux Tel. 78144 mailto:nathalie.dumeaux@cern.ch

  1. The 2014 Academic College of Emergency Experts in India's Education Development Committee (EDC) White Paper on establishing an academic department of Emergency Medicine in India - Guidelines for Staffing, Infrastructure, Resources, Curriculum and Training.

    Science.gov (United States)

    Aggarwal, Praveen; Galwankar, Sagar; Kalra, Om Prakash; Bhalla, Ashish; Bhoi, Sanjeev; Sundarakumar, Sundarajan

    2014-07-01

    Emergency medicine services and training in Emergency Medicine (EM) has developed to a large extent in developed countries but its establishment is far from optimal in developing countries. In India, Medical Council of India (MCI) has taken great steps by notifying EM as a separate specialty and so far 20 medical colleges have already initiated 3-year training program in EM. However, there has been shortage of trained faculty, and ambiguity regarding curriculum, rotation policy, infrastructure, teachers' eligibility qualifications and scheme of examination. Academic College of Emergency Experts in India (ACEE-India) has been a powerful advocate for developing Academic EM in India. The ACEE's Education Development Committee (EDC) was created to chalk out guidelines for staffing, infrastructure, resources, curriculum, and training which may be of help to the MCI and the National Board of Examinations (NBE) to set standards for starting 3-year training program in EM and develop the departments of EM as centers of quality education, research, and treatment across India. This paper has made an attempt to give recommendations so as to provide a uniform framework to the institutions, thus guiding them towards establishing an academic Department of EM for starting the 3-year training program in the specialty of EM.

  2. The 2014 Academic College of Emergency Experts in India′s Education Development Committee (EDC White Paper on establishing an academic department of Emergency Medicine in India - Guidelines for Staffing, Infrastructure, Resources, Curriculum and Training

    Directory of Open Access Journals (Sweden)

    Praveen Aggarwal

    2014-01-01

    Full Text Available Emergency medicine services and training in Emergency Medicine (EM has developed to a large extent in developed countries but its establishment is far from optimal in developing countries. In India, Medical Council of India (MCI has taken great steps by notifying EM as a separate specialty and so far 20 medical colleges have already initiated 3-year training program in EM. However, there has been shortage of trained faculty, and ambiguity regarding curriculum, rotation policy, infrastructure, teachers′ eligibility qualifications and scheme of examination. Academic College of Emergency Experts in India (ACEE-India has been a powerful advocate for developing Academic EM in India. The ACEE′s Education Development Committee (EDC was created to chalk out guidelines for staffing, infrastructure, resources, curriculum, and training which may be of help to the MCI and the National Board of Examinations (NBE to set standards for starting 3-year training program in EM and develop the departments of EM as centers of quality education, research, and treatment across India. This paper has made an attempt to give recommendations so as to provide a uniform framework to the institutions, thus guiding them towards establishing an academic Department of EM for starting the 3-year training program in the specialty of EM.

  3. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrates unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) 10:30 -...

  4. Correlation between athlete training intensity and cardiac performance

    African Journals Online (AJOL)

    2016-09-03

    Sep 3, 2016 ... Department of Zhengzhou University, Zhengzhou, 1The Third Xiang-ya Hospital, .... Under corresponding emergency situation, the body .... Bu Y, Liu D. Physical Training Process of Chinese Women's Soccer Team - Based.

  5. ACADEMIC TRAINING

    CERN Multimedia

    Françoise Benz

    2002-01-01

    6, 7 May LECTURE SERIES from 11.00 to 12.00 hrs - Auditorium, bldg. 500 Decoding the Human Genome, Scientific basis and ethic and social aspects by S.E. Antonarakis and A. Mauron / Univ. of Geneva Decoding the Human genome is a very up-to-date topic, raising several questions besides purely scientific, in view of the two competing teams (public and private), the ethics of using the results, and the fact that the project went apparently faster and easier than expected. The lecture series will address the following chapters: Scientific basis and challenges, Ethical and social aspects of genomics. Academic Training Françoise Benz Tel. 73127

  6. Media Training

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    With the LHC starting up soon, the world's media are again turning their attention to CERN. We're all likely to be called upon to explain what is happening at CERN to media, friends and neighbours. The seminar will be given by BBC television news journalists Liz Pike and Nadia Marchant, and will deal with the kind of questions we're likely to be confronted with through the restart period. The training is open for everybody. Make sure you arrive early enough to get a seat - there are only 200 seats in the Globe. The session will also be webcast: http://webcast.cern.ch/

  7. Recent trends of citation status and suggestions for improved the academic authority of the journal of the Korean radiological society during 2000-2005: analysis of all citations using KoMCI

    International Nuclear Information System (INIS)

    Park, Soo Youn; Kim, Hyun Jin; Ihn, Yon Kwon; Cha, Eun Suk; Hwang, Seong Su

    2006-01-01

    We wanted to analyze the citation trend and to find a way to improve the impact factor (IF) of the Journal of the Korean Radiological Society (JKRS). The number of articles and references, the total citations and self-citations, the IF and the IF excluding self-citations (ZIF) were described by an analysis of Korean Medical Citation Index (KoMCI) during 2000-2005. The total and self citations of the JKRS were compared to that of the Top 5 journals. There was a 57% decrease of papers for 6 years. The Korean references/paper ranged from 0.98-0.85. The number of total citations received steadily decreased from 394 in 2000 to 180 in 2005. The IF (ZF) of the JKRS has been gradually lowered from 0.142 (0.049) in 2000 to 0.063 (0.059) in 2005. Although the total citations that cited all papers published/the annual number of papers was 55% of that of the top 5 journals, the total citations citing papers published within the recent two years was only 24% of that of the top 5 journals. The citation status of the JKRS has steadily decreased for the recent 6 years, and the IF of the JKRS was very low among all the Korean medical journals. To improve the IF, active advertising for the journal members of the importance of the IF is needed to encourage citing JKRS papers that have been published within the recent two years

  8. Management competencies in higher education: Perceived job importance in relation to level of training required

    Directory of Open Access Journals (Sweden)

    Ingrid L. Potgieter

    2010-11-01

    Research purpose: The aim of this article is to determine the relationship between a specific set of HOD managerial competencies identified as being important for the job and the level of training required in terms of these competencies. Motivation for the study: Research has provided evidence that HODs are often ill-prepared for their managerial role, which requires the development of specific management competencies to enable them to fulfil their roles effectively. Research design, approach and method: A non-experimental quantitative survey design approach was followed and correlational data analyses were performed. A cross-sectional sample of 41 HODs of 22 departments from various faculties of a higher education institution in Gauteng participated in this study. The Management Competency Inventory (MCI of Visser (2009 was applied as a measure. Main findings: The Pearson product-moment analysis indicated that there is a significant relationship between the competencies indicated as being important for the job and the level of training required. Practical/Managerial implications: Training needs of HODs should be formally assessed and the depth of training required in terms of the identified management competencies should be considered in the design of training programmes. Contributions/Value-add: The information obtained in this study may potentially serve as a foundation for the development of an HOD training programme in the South African higher education environment.

  9. Chapter 5: Training

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2018-04-01

    The chapter 5 presents the 1) initial training; 2) periodic training, which includes: a) periodic training for employees at lower levels of the hierarchy than that of the operator; b) period training for operators; 3) operator training; 4) record of training; 5) safety culture.

  10. French training

    CERN Multimedia

    2007-01-01

    The next session will take place from 29 January to 30 March 2007. These courses are open to all persons working on the CERN site, and their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel. 73127. Writing Professional Documents in French The next session will take place from 29 January to 30 March 2007. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF (for 8 students) For further information and registration, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel. 73127. Writing Professional Documents in English The next session will take place from January to June 2007 (break at Easter). This course is designed for people with a good level of spoken English. Duration: 30 hours Price: 660 CHF (for 8 students) Timetable will be fixed after discussion with the students. For further information and registration, please consu...

  11. English Training

    CERN Multimedia

    2003-01-01

    General and Professional English Courses The next session will take place: from 03 March to 28 June 2003 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel.73127 or Mr. Liptow: tel.72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mrs. Tessa Osborne: Tessa.Osborne@cern. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, rol...

  12. English Training

    CERN Multimedia

    2003-01-01

    General and Professional English Courses The next session will take place: from 03 March to 28 June 2003 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel.73127 or Mr. Liptow: tel.72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mrs. Tessa Osborne: Tessa.Osborne@cern. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-p...

  13. Language Training

    CERN Multimedia

    2003-01-01

    Formation en anglais Cours d'anglais général et professionnel La prochaine session se déroulera: du 06 octobre 2003 au 13 février 2004 (interruption de 3/4 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web: http://cern.ch/Training Vous pouvez aussi contacter Mme Benz, tél. 73127 ou Mr Liptow, tél. 72957. General and Professional English Courses The next session will take place: from 06 October 2003 to 13 February 2004 (3/4 weeks break at Christmas). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel. 73127 or Mr. Liptow: tel. 72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: ...

  14. Language Training

    CERN Multimedia

    2003-01-01

    Formation en anglais Cours d'anglais général et professionnel La prochaine session se déroulera: du 06 octobre 2003 au 13 février 2004 (interruption de 3/4 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web: http://cern.ch/Training Vous pouvez aussi contacter M. Liptow, tél. 72957. General and Professional English Courses The next session will take place: from 06 October 2003 to 13 February 2004 (3/4 weeks break at Christmas). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957. Writing Professional Documents in English This course is designed for people with a good level of...

  15. Language Training

    CERN Multimedia

    2003-01-01

    Formation en anglais Cours d'anglais général et professionnel La prochaine session se déroulera: du 06 octobre 2003 au 13 février 2004 (interruption de 3/4 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web: http://cern.ch/Training Vous pouvez aussi contacter Mme Benz, tél. 73127 ou Mr Liptow, tél. 72957. General and Professional English Courses The next session will take place: from 06 October 2003 to 13 February 2004 (3/4 weeks break at Christmas). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel. 73127 or Mr. Liptow: tel. 72957. Writing Professional Documents in Engl...

  16. Programa de intervenção fonológica associado à correspondência grafema-fonema em escolares de risco para a dislexia Phonological intervention program associated with grapheme-phoneme correspondence in students at risk for dyslexia

    Directory of Open Access Journals (Sweden)

    Maryse Tomoko Matsuzawa Fukuda

    2012-01-01

    Full Text Available Este estudo objetivou identificar os escolares com sinais de risco para a dislexia e verificar a eficácia do programa de treinamento fonológico associado à correspondência grafema-fonema nessa população. Participaram deste estudo 60 escolares divididos em: GI, composto por 30 escolares submetidos ao programa de treinamento, e GII, composto por 30 escolares não submetidos ao programa de treinamento. Os resultados revelaram que, após o período de realização do programa de treinamento, o GI apresentou diferenças estatisticamente significantes em todas as habilidades propostas na avaliação. Conclui-se que o programa de treinamento das habilidades fonológicas e correspondência grafema-fonema foi eficaz para a identificação dos escolares com sinais de dislexia, comprovando-se pela melhora das habilidades cognitivo-linguísticas na situação de pós-testagem em relação à pré-testagem.This study aimed to identify students at risk for dyslexia and verify the efficacy of the phonological training and grapheme-phoneme correspondence program with such students. Sixty students participated in the study. They were divided into GI, consisting of 30 students who were submitted to the training program, and GII, consisting of 30 students who were not submitted to the training program. The results showed that the GI present statistically significant differences in all skills proposed in the evaluation after the training program. It is concluded that the phonological ability training and grapheme-phoneme correspondence program were effective for the identification of students with signs of dyslexia. It was proven by the improvement of the phonological abilities of reading in the post-testing situation compared to pre-testing.

  17. Unification of the Two-Parameter Equation of State and the Principle of Corresponding States

    DEFF Research Database (Denmark)

    Mollerup, Jørgen

    1998-01-01

    A two-parameter equation of state is a two-parameter corresponding states model. A two-parameter corresponding states model is composed of two scale factor correlations and a reference fluid equation of state. In a two-parameter equation of state the reference equation of state is the two-paramet...

  18. 14 CFR 23.29 - Empty weight and corresponding center of gravity.

    Science.gov (United States)

    2010-01-01

    ... gravity. 23.29 Section 23.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight General § 23.29 Empty weight and corresponding center of gravity. (a) The empty weight and corresponding center of gravity must be determined by weighing the airplane with— (1) Fixed ballast; (2...

  19. 19 CFR 111.29 - Diligence in correspondence and paying monies.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Diligence in correspondence and paying monies. 111...; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs Brokers § 111.29 Diligence in correspondence and paying monies. (a) Due diligence by broker. Each broker must exercise due...

  20. Proposed Accreditation Standards for Degree-Granting Correspondence Programs Offered by Accredited Institutions.

    Science.gov (United States)

    McGraw-Hill Continuing Education Center, Washington, DC.

    A study on proposed accreditation standards grew out of a need to (1) stimulate the growth of quality correspondence degree programs; and (2) provide a policy for accreditation of correspondence degree programs so that graduates would be encouraged to pursue advanced degree programs offered elsewhere by educational institutions. The study focused…

  1. "Are You Only an Applauder?" American Music Correspondence Schools in the Early Twentieth Century

    Science.gov (United States)

    Vogel, Dorothy

    2015-01-01

    The purpose of this study was to examine correspondence schools of music in the early twentieth century. Advertisements in widely circulated household and music periodicals and archival copies of courses from Siegel-Myers Correspondence School of Music, United States School of Music, American College of Music, and others were examined. Research…

  2. 34 CFR 668.38 - Enrollment in telecommunications and correspondence courses.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Enrollment in telecommunications and correspondence... Student Eligibility § 668.38 Enrollment in telecommunications and correspondence courses. (a) If a student..., or graduate degree. (b)(1) For purposes of this section, a student enrolled in a telecommunications...

  3. Reconstructing rotations and rigid body motions from exact point correspondences through reflections

    NARCIS (Netherlands)

    Fontijne, D.; Dorst, L.; Dorst, L.; Lasenby, J.

    2011-01-01

    We describe a new algorithm to reconstruct a rigid body motion from point correspondences. The algorithm works by constructing a series of reflections which align the points with their correspondences one by one. This is naturally and efficiently implemented in the conformal model of geometric

  4. 37 CFR 5.1 - Applications and correspondence involving national security.

    Science.gov (United States)

    2010-07-01

    ... correspondence involving national security. 5.1 Section 5.1 Patents, Trademarks, and Copyrights UNITED STATES... involving national security. (a) All correspondence in connection with this part, including petitions... national security classified (see § 1.9(i) of this chapter) and contain authorized national security...

  5. Writings and correspondence: 1961-1985: Hubert Damisch and Jean Dubuffet

    NARCIS (Netherlands)

    Berrebi, S.

    2015-01-01

    This dossier comprises a selection of the correspondence between Hubert Damisch and Jean Dubuffet as well as six essays written by Damisch on Dubuffet between 1962 and 1985. Both the correspondence and texts are here published in English for the first time. "Jean Dubuffet and the Awakening of

  6. Relationship of Vocational Satisfaction to the Correspondence of Job Reinforcement and Vocational Needs.

    Science.gov (United States)

    Golden, Robert R.; Weiss, David J.

    The Theory of Work Adjustment proposes that vocational satisfaction is a function of the correspondence between the reinforcers in the work environment and the individual's vocational needs. This hypothesis is tested by comparing the means and variances of measures of satisfaction for groups differing in degree of need-reinforcer correspondence.…

  7. Strength Training. A Key to Athletic Training.

    Science.gov (United States)

    Whiteside, Patricia W.

    Characteristics of an effective strength training program are analyzed and descriptions are offered of different kinds of weight training activities. Comparisons are made between concentric, isometric, eccentric, and isokinetic training methods. The fundamentals and techniques of an exemplary training program are outlined and the organization and…

  8. Computer-Based Training Development and Guidance for the Army’s Unmanned Aviation Systems Maintenance Training Division

    Science.gov (United States)

    2017-08-01

    When they view the graphics or animation they cannot look at and read the text. When they read the text they cannot view the graphics or animation ...and animation in learner-paced segments Pre-training Provide essential pre-training Modality Consider narrations versus printed text Reduce...text to narrated animation Spatial contiguity Place on-screen text next to corresponding graphics Temporal contiguity Present corresponding

  9. Geometric Integration of Hybrid Correspondences for RGB-D Unidirectional Tracking

    Directory of Open Access Journals (Sweden)

    Shengjun Tang

    2018-05-01

    Full Text Available Traditionally, visual-based RGB-D SLAM systems only use correspondences with valid depth values for camera tracking, thus ignoring the regions without 3D information. Due to the strict limitation on measurement distance and view angle, such systems adopt only short-range constraints which may introduce larger drift errors during long-distance unidirectional tracking. In this paper, we propose a novel geometric integration method that makes use of both 2D and 3D correspondences for RGB-D tracking. Our method handles the problem by exploring visual features both when depth information is available and when it is unknown. The system comprises two parts: coarse pose tracking with 3D correspondences, and geometric integration with hybrid correspondences. First, the coarse pose tracking generates the initial camera pose using 3D correspondences with frame-by-frame registration. The initial camera poses are then used as inputs for the geometric integration model, along with 3D correspondences, 2D-3D correspondences and 2D correspondences identified from frame pairs. The initial 3D location of the correspondence is determined in two ways, from depth image and by using the initial poses to triangulate. The model improves the camera poses and decreases drift error during long-distance RGB-D tracking iteratively. Experiments were conducted using data sequences collected by commercial Structure Sensors. The results verify that the geometric integration of hybrid correspondences effectively decreases the drift error and improves mapping accuracy. Furthermore, the model enables a comparative and synergistic use of datasets, including both 2D and 3D features.

  10. Markov Random Field Restoration of Point Correspondences for Active Shape Modelling

    DEFF Research Database (Denmark)

    Hilger, Klaus Baggesen; Paulsen, Rasmus Reinhold; Larsen, Rasmus

    2004-01-01

    In this paper it is described how to build a statistical shape model using a training set with a sparse of landmarks. A well defined model mesh is selected and fitted to all shapes in the training set using thin plate spline warping. This is followed by a projection of the points of the warped...

  11. Correspondents and the Cold War. How foreign correspondents acted during the chancellery of Helmut Schmidt (1974-1982 in Germany and abroad

    Directory of Open Access Journals (Sweden)

    Thomas Birkner

    2016-09-01

    Full Text Available This paper addresses the role of foreign correspondents during the Cold War. More specifically, it focuses on the case study of the relationship between former German Chancellor Helmut Schmidt and foreign correspondents in Germanyand abroad. A synthesis of historical research and qualitative analysis of documentsand interviews provides a behind-the-scenes look at media diplomacy during the 70s andearly 80s. From the perspective of system theory and the concept of mediatization, mediaand politics are understood as separate but equal social systems that interact with eachother. This case study is based on documents from the private archives of Helmut Schmidtand from the annals of his party, the German Social Democrats, as well as interviews conducted with Schmidt and former journalist and correspondent Gerd Ruge. Analysis of theinterviews and the private and secret correspondence of Schmidt with journalists affordsan inside view into the role foreign correspondents played during the Cold War when communicationacross the Iron Curtain was especially challenging. Our conclusions show howimportant foreign correspondents are in international relations, while also demonstrating that aspects of international diplomacy, though involving journalists, were not necessarily included in media coverage. This study helps to clarify the complex interactions between media and politics. On the basis of our explorative research, a model is proffered of possible relations and interactions between politicians and foreign correspondents. As sources of information and means of communication, foreign correspondents exert a strong influence on the fates of nations and governments, before and behind the scenes. Esta proposta aborda o papel dos correspondentes estrangeiros durante a Guerra Fria. Mais especificamente, centra-se no estudo de caso da relação entre o ex-chanceler alemão Helmut Schmidt e os correspondentes estrangeiros na Alemanha e no exterior. A s

  12. Training apparatus

    International Nuclear Information System (INIS)

    Monteith, W.D.

    1983-01-01

    Training apparatus for use in contamination surveillance uses a mathematical model of a hypothetical contamination source (e.g. nuclear, bacteriological or chemical explosion or leak) to determine from input data defining the contamination source, the contamination level at any location within a defined exercise area. The contamination level to be displayed by the apparatus is corrected to real time from a real time clock or may be displayed in response to a time input from a keyboard. In a preferred embodiment the location is defined by entering UTM grid reference coordinates using the keyboard. The mathematical model used by a microprocessor of the apparatus for simulation of contamination levels in the event of a nuclear explosion is described. (author)

  13. ACADEMIC TRAINING

    CERN Multimedia

    Françoise Benz

    2002-01-01

    25, 26, 27, 28 February and 1st March from 11.00 to 12.00 hrs - Auditorium, bldg. 500 LECTURE SERIES Neutrino masses and oscillations by A. de Rujula / CERN-TH This course will not cover its subject in the customary way. The emphasis will be on the simple theoretical concepts (helicity, handedness, chirality, Majorana masses) which are obscure in most of the literature, and on the quantum mechanics of oscillations, that ALL books get wrong. Which, hopefully, will not deter me from discussing some of the most interesting results from the labs and from the cosmos. Academic Training Françoise Benz Secretariat Tel. 73127 francoise.benz@cern.ch

  14. English training

    CERN Multimedia

    2003-01-01

    You have a good level of English BUT... You still need to improve your speaking or You have problems writing professional documents Would you like to work in a small group on either of these areas? Then, the following courses are for you! Writing Professional Documents in English The aim of the course is for students to improve their professional writing. Participants will work on technical, scientific or administrative documents depending on the needs of the group. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) Oral Expression The emphasis will be on oral expression with necessary feed-back. Speaking activities will include discussions, meeting simulations, role-plays etc. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957 / Mrs. Tessa Osborne: Tessa.Osborne@cern.ch.

  15. English Training

    CERN Multimedia

    2003-01-01

    You have a good level of English BUT... You still need to improve your speaking or You have problems writing professional documents Would you like to work in a small group on either of these areas? Then, the following courses are for you! Writing Professional Documents in English The aim of the course is for students to improve their professional writing. Participants will work on technical, scientific or administrative documents depending on the needs of the group. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) Oral Expression The emphasis will be on oral expression with necessary feed-back. Speaking activities will include discussions, meeting simulations, role-plays etc. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957 / Mrs. Tessa Osborne: Tessa.Osborne@cern.ch.

  16. Scenistic Methods in Training: Definitions and Theory Grounding

    Science.gov (United States)

    Lyons, Paul

    2010-01-01

    Purpose: The aim of this article is to describe the scenistic approach to training with corresponding activities and the theory bases that support the approach. Design/methodology/approach: Presented is the definition of the concept of scenistic training along with the step-by-step details of the implementation of the approach. Scenistic methods,…

  17. More Training, Less Security? Training and the Quality of Life at Work in Argentina, Brazil and Chile.

    Science.gov (United States)

    Jeria Caceres, Maria Mercedes

    2002-01-01

    Conditional multiple correspondence analysis of data from workers in Argentina, Brazil, and Chile found that training was a consequence rather than a cause of promotion. More job training resulted in increased salary and benefits as well as in greater costs such as hours of work and work-related insecurity. (Contains 21 references.) (JOW)

  18. Autogenic Training and Professional Pedagogy (Training Autogeno e Pedagogia Professionale

    Directory of Open Access Journals (Sweden)

    Franco Blezza

    2017-12-01

    Full Text Available Autogenic Training (das Autogenes Training is a procedure that has been proposed by J. H. Schultz in 1932, originally with the purpose of relaxation, but which over the decades extended its role and its applications for the most varied of enhancing human personal resources. His teaching is practiced by different professionals. In this paper we discuss the contribution of social and professional pedagogy in this context and the corresponding practice, considering the methodology, didactics, the conception of the helping and assistance relationship to the person and the contribution non therapeutic to health. Even the linguistic problems in the translation from German to Italian language require attention. In the AT the professional pedagogist, apical professional in educational problems find its field of scope and exercise which has many original and very interesting features.

  19. Advanced training systems

    Science.gov (United States)

    Savely, Robert T.; Loftin, R. Bowen

    1990-01-01

    Training is a major endeavor in all modern societies. Common training methods include training manuals, formal classes, procedural computer programs, simulations, and on-the-job training. NASA's training approach has focussed primarily on on-the-job training in a simulation environment for both crew and ground based personnel. NASA must explore new approaches to training for the 1990's and beyond. Specific autonomous training systems are described which are based on artificial intelligence technology for use by NASA astronauts, flight controllers, and ground based support personnel that show an alternative to current training systems. In addition to these specific systems, the evolution of a general architecture for autonomous intelligent training systems that integrates many of the features of traditional training programs with artificial intelligence techniques is presented. These Intelligent Computer Aided Training (ICAT) systems would provide much of the same experience that could be gained from the best on-the-job training.

  20. Nuclear manpower training

    International Nuclear Information System (INIS)

    Suh, In Suk; Lee, H. Y.; Joe, B. J.; Lee, S. H.; Lee, E. J.; Yoo, B. H.; Seo, K. W.; Lee, W. K.; Jun, H. I.; Yang, K. N.; Kim, Y. J.; Kim, I. H.; Kim, M. Y.; Ju, Y. C.; Hyun, H. Y.; Choi, I. G.; Hong, C. S.; Won, J. Y.; Nam, J. Y.; Lee, H. J.

    1997-01-01

    This report describes the annual results of training courses. the scope and contents are as follows: 1. Regional and interregional training courses 2. Training courses assisted by foreign experts 3. Training courses for nuclear industry personnel 4. Training courses for internal staff-members 5. Training courses under the law. This Nuclear Training Center executed the open-door training courses for 2,400 engineers/scientists from the regulatory body, nuclear industries, research institutes and other related organizations by means of offering 51 training courses during the fiscal year 1996. (author). 23 refs