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  1. Task performance changes the amplitude and timing of the BOLD signal

    Directory of Open Access Journals (Sweden)

    Akhrif Atae

    2017-12-01

    Full Text Available Translational studies comparing imaging data of animals and humans have gained increasing scientific interests. With this upcoming translational approach, however, identifying harmonized statistical analysis as well as shared data acquisition protocols and/or combined statistical approaches is necessary. Following this idea, we applied Bayesian Adaptive Regression Splines (BARS, which have until now mainly been used to model neural responses of electrophysiological recordings from rodent data, on human hemodynamic responses as measured via fMRI. Forty-seven healthy subjects were investigated while performing the Attention Network Task in the MRI scanner. Fluctuations in the amplitude and timing of the BOLD response were determined and validated externally with brain activation using GLM and also ecologically with the influence of task performance (i.e. good vs. bad performers. In terms of brain activation, bad performers presented reduced activation bilaterally in the parietal lobules, right prefrontal cortex (PFC and striatum. This was accompanied by an enhanced left PFC recruitment. With regard to the amplitude of the BOLD-signal, bad performers showed enhanced values in the left PFC. In addition, in the regions of reduced activation such as the parietal and striatal regions, the temporal dynamics were higher in bad performers. Based on the relation between BOLD response and neural firing with the amplitude of the BOLD signal reflecting gamma power and timing dynamics beta power, we argue that in bad performers, an enhanced left PFC recruitment hints towards an enhanced functioning of gamma-band activity in a compensatory manner. This was accompanied by reduced parieto-striatal activity, associated with increased and potentially conflicting beta-band activity.

  2. Relationship between BOLD amplitude and pattern classification of orientation-selective activity in the human visual cortex

    Science.gov (United States)

    Tong, Frank; Harrison, Stephenie A.; Dewey, John A.; Kamitani, Yukiyasu

    2012-01-01

    Orientation-selective responses can be decoded from fMRI activity patterns in the human visual cortex, using multivariate pattern analysis (MVPA). To what extent do these feature-selective activity patterns depend on the strength and quality of the sensory input, and might the reliability of these activity patterns be predicted by the gross amplitude of the stimulus-driven BOLD response? Observers viewed oriented gratings that varied in luminance contrast (4, 20 or 100%) or spatial frequency (0.25, 1.0 or 4.0 cpd). As predicted, activity patterns in early visual areas led to better discrimination of orientations presented at high than low contrast, with greater effects of contrast found in area V1 than in V3. A second experiment revealed generally better decoding of orientations at low or moderate as compared to high spatial frequencies. Interestingly however, V1 exhibited a relative advantage at discriminating high spatial frequency orientations, consistent with the finer scale of representation in the primary visual cortex. In both experiments, the reliability of these orientation-selective activity patterns was well predicted by the average BOLD amplitude in each region of interest, as indicated by correlation analyses, as well as decoding applied to a simple model of voxel responses to simulated orientation columns. Moreover, individual differences in decoding accuracy could be predicted by the signal-to-noise ratio of an individual's BOLD response. Our results indicate that decoding accuracy can be well predicted by incorporating the amplitude of the BOLD response into simple simulation models of cortical selectivity; such models could prove useful in future applications of fMRI pattern classification. PMID:22917989

  3. Non-linear Relationship between BOLD Activation and Amplitude of Beta Oscillations in the Supplementary Motor Area during Rhythmic Finger Tapping and Internal Timing

    Science.gov (United States)

    Gompf, Florian; Pflug, Anja; Laufs, Helmut; Kell, Christian A.

    2017-01-01

    Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA, motor and non-motor tasks that rely on internal timing increase the amplitude of beta oscillations in the SMA. These independent observations suggest that the relationship between beta oscillations and BOLD activation is more complex than previously thought. Here we set out to investigate this rapport by examining beta oscillations in the SMA during movement with varying degrees of internal timing demands. In a simultaneous EEG-fMRI experiment, 20 healthy right-handed subjects performed an auditory-paced finger-tapping task. Internal timing was operationalized by including conditions with taps on every fourth auditory beat, which necessitates generation of a slow internal rhythm, while tapping to every auditory beat reflected simple auditory-motor synchronization. In the SMA, BOLD activity increased and power in both the low and the high beta band decreased expectedly during each condition compared to baseline. Internal timing was associated with a reduced desynchronization of low beta oscillations compared to conditions without internal timing demands. In parallel with this relative beta power increase, internal timing activated the SMA more strongly in terms of BOLD. This documents a task-dependent non-linear relationship between BOLD and beta-oscillations in the SMA. We discuss different roles of beta synchronization and desynchronization in active processing within the same cortical region. PMID:29249950

  4. Non-linear Relationship between BOLD Activation and Amplitude of Beta Oscillations in the Supplementary Motor Area during Rhythmic Finger Tapping and Internal Timing.

    Science.gov (United States)

    Gompf, Florian; Pflug, Anja; Laufs, Helmut; Kell, Christian A

    2017-01-01

    Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA, motor and non-motor tasks that rely on internal timing increase the amplitude of beta oscillations in the SMA. These independent observations suggest that the relationship between beta oscillations and BOLD activation is more complex than previously thought. Here we set out to investigate this rapport by examining beta oscillations in the SMA during movement with varying degrees of internal timing demands. In a simultaneous EEG-fMRI experiment, 20 healthy right-handed subjects performed an auditory-paced finger-tapping task. Internal timing was operationalized by including conditions with taps on every fourth auditory beat, which necessitates generation of a slow internal rhythm, while tapping to every auditory beat reflected simple auditory-motor synchronization. In the SMA, BOLD activity increased and power in both the low and the high beta band decreased expectedly during each condition compared to baseline. Internal timing was associated with a reduced desynchronization of low beta oscillations compared to conditions without internal timing demands. In parallel with this relative beta power increase, internal timing activated the SMA more strongly in terms of BOLD. This documents a task-dependent non-linear relationship between BOLD and beta-oscillations in the SMA. We discuss different roles of beta synchronization and desynchronization in active processing within the same cortical region.

  5. Spatial attention related SEP amplitude modulations covary with BOLD signal in S1--a simultaneous EEG--fMRI study.

    Science.gov (United States)

    Schubert, Ruth; Ritter, Petra; Wüstenberg, Torsten; Preuschhof, Claudia; Curio, Gabriel; Sommer, Werner; Villringer, Arno

    2008-11-01

    Recent studies investigating the influence of spatial-selective attention on primary somatosensory processing have produced inconsistent results. The aim of this study was to explore the influence of tactile spatial-selective attention on spatiotemporal aspects of evoked neuronal activity in the primary somatosensory cortex (S1). We employed simultaneous electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) in 14 right-handed subjects during bilateral index finger Braille stimulation to investigate the relationship between attentional effects on somatosensory evoked potential (SEP) components and the blood oxygenation level-dependent (BOLD) signal. The 1st reliable EEG response following left tactile stimulation (P50) was significantly enhanced by spatial-selective attention, which has not been reported before. FMRI analysis revealed increased activity in contralateral S1. Remarkably, the effect of attention on the P50 component as well as long-latency SEP components starting at 190 ms for left stimuli correlated with attentional effects on the BOLD signal in contralateral S1. The implications are 2-fold: First, the correlation between early and long-latency SEP components and the BOLD effect suggest that spatial-selective attention enhances processing in S1 at 2 time points: During an early passage of the signal and during a later passage, probably via re-entrant feedback from higher cortical areas. Second, attentional modulations of the fast electrophysiological signals and the slow hemodynamic response are linearly related in S1.

  6. P300 amplitude variation is related to ventral striatum BOLD response during gain and loss anticipation: an EEG and fMRI experiment.

    Science.gov (United States)

    Pfabigan, Daniela M; Seidel, Eva-Maria; Sladky, Ronald; Hahn, Andreas; Paul, Katharina; Grahl, Arvina; Küblböck, Martin; Kraus, Christoph; Hummer, Allan; Kranz, Georg S; Windischberger, Christian; Lanzenberger, Rupert; Lamm, Claus

    2014-08-01

    The anticipation of favourable or unfavourable events is a key component in our daily life. However, the temporal dynamics of anticipation processes in relation to brain activation are still not fully understood. A modified version of the monetary incentive delay task was administered during separate functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) sessions in the same 25 participants to assess anticipatory processes with a multi-modal neuroimaging set-up. During fMRI, gain and loss anticipation were both associated with heightened activation in ventral striatum and reward-related areas. EEG revealed most pronounced P300 amplitudes for gain anticipation, whereas CNV amplitudes distinguished neutral from gain and loss anticipation. Importantly, P300, but not CNV amplitudes, were correlated to neural activation in the ventral striatum for both gain and loss anticipation. Larger P300 amplitudes indicated higher ventral striatum blood oxygen level dependent (BOLD) response. Early stimulus evaluation processes indexed by EEG seem to be positively related to higher activation levels in the ventral striatum, indexed by fMRI, which are usually associated with reward processing. The current results, however, point towards a more general motivational mechanism processing salient stimuli during anticipation. Copyright © 2014. Published by Elsevier Inc.

  7. Music reduces pain and increases resting state fMRI BOLD signal amplitude in the left angular gyrus in fibromyalgia patients

    DEFF Research Database (Denmark)

    Garza-Villarreal, Eduardo A; Jiang, Zhiguo; Vuust, Peter

    2015-01-01

    , correlated to the analgesia reports. The post-hoc seed-based functional connectivity analysis of the lAnG showed found higher connectivity after listening to music with right dorsolateral prefrontal cortex (rdlPFC), the left caudate (lCau), and decreased connectivity with right anterior cingulate cortex (r......Music reduces pain in fibromyalgia (FM), a chronic pain disease, but the functional neural correlates of music-induced analgesia (MIA) are still largely unknown. We recruited FM patients (n = 22) who listened to their preferred relaxing music and an auditory control (pink noise) for 5 min without...... external noise from fMRI image acquisition. Resting state fMRI was then acquired before and after the music and control conditions. A significant increase in the amplitude of low frequency fluctuations of the BOLD signal was evident in the left angular gyrus (lAnG) after listening to music, which in turn...

  8. Music reduces pain and increases resting state fMRI BOLD signal amplitude in the left angular gyrus in fibromyalgia patients

    Directory of Open Access Journals (Sweden)

    Eduardo A. Garza-Villarreal

    2015-07-01

    Full Text Available Music reduces pain in fibromyalgia (FM, a chronic pain disease, but the functional neural correlates of music-induced analgesia are still largely unknown. We recruited FM patients (n = 22 who listened to their preferred relaxing music and an auditory control (pink noise for 5 minutes without external noise from fMRI image acquisition. Resting state fMRI was then acquired before and after the music and control conditions. A significant increase in the amplitude of low frequency fluctuations of the BOLD signal was evident in the left angular gyrus after listening to music, which in turn, correlated to the analgesia reports. The post-hoc seed-based functional connectivity analysis of the left angular gyrus showed found higher connectivity after listening to music with right dorsolateral prefrontal cortex, the left caudate, and decreased connectivity with right anterior cingulate cortex, right supplementary motor area, precuneus and right precentral gyrus. Pain intensity analgesia was correlated (r = .61 to the connectivity of the left angular gyrus with the right precentral gyrus. Our results show that music-induced analgesia in FM is related to top-down regulation of the pain modulatory network by the default-mode network.

  9. Wavelength selection in injection-driven Hele-Shaw flows: A maximum amplitude criterion

    Science.gov (United States)

    Dias, Eduardo; Miranda, Jose

    2013-11-01

    As in most interfacial flow problems, the standard theoretical procedure to establish wavelength selection in the viscous fingering instability is to maximize the linear growth rate. However, there are important discrepancies between previous theoretical predictions and existing experimental data. In this work we perform a linear stability analysis of the radial Hele-Shaw flow system that takes into account the combined action of viscous normal stresses and wetting effects. Most importantly, we introduce an alternative selection criterion for which the selected wavelength is determined by the maximum of the interfacial perturbation amplitude. The effectiveness of such a criterion is substantiated by the significantly improved agreement between theory and experiments. We thank CNPq (Brazilian Sponsor) for financial support.

  10. Speed Control Analysis of Brushless DC Motor Based on Maximum Amplitude DC Current Feedback

    Directory of Open Access Journals (Sweden)

    Hassan M.A.A.

    2014-07-01

    Full Text Available This paper describes an approach to develop accurate and simple current controlled modulation technique for brushless DC (BLDC motor drive. The approach is applied to control phase current based on generation of quasi-square wave current by using only one current controller for the three phases. Unlike the vector control method which is complicated to be implemented, this simple current modulation technique presents advantages such as phase currents are kept in balance and the current is controlled through only one dc signal which represent maximum amplitude value of trapezoidal current (Imax. This technique is performed with Proportional Integral (PI control algorithm and triangular carrier comparison method to generate Pulse Width Modulation (PWM signal. In addition, the PI speed controller is incorporated with the current controller to perform desirable speed operation of non-overshoot response. The performance and functionality of the BLDC motor driver are verified via simulation by using MATLAB/SIMULINK. The simulation results show the developed control system performs desirable speed operation of non-overshoot and good current waveforms.

  11. Single-trial EEG-informed fMRI reveals spatial dependency of BOLD signal on early and late IC-ERP amplitudes during face recognition.

    Science.gov (United States)

    Wirsich, Jonathan; Bénar, Christian; Ranjeva, Jean-Philippe; Descoins, Médéric; Soulier, Elisabeth; Le Troter, Arnaud; Confort-Gouny, Sylviane; Liégeois-Chauvel, Catherine; Guye, Maxime

    2014-10-15

    Simultaneous EEG-fMRI has opened up new avenues for improving the spatio-temporal resolution of functional brain studies. However, this method usually suffers from poor EEG quality, especially for evoked potentials (ERPs), due to specific artifacts. As such, the use of EEG-informed fMRI analysis in the context of cognitive studies has particularly focused on optimizing narrow ERP time windows of interest, which ignores the rich diverse temporal information of the EEG signal. Here, we propose to use simultaneous EEG-fMRI to investigate the neural cascade occurring during face recognition in 14 healthy volunteers by using the successive ERP peaks recorded during the cognitive part of this process. N170, N400 and P600 peaks, commonly associated with face recognition, were successfully and reproducibly identified for each trial and each subject by using a group independent component analysis (ICA). For the first time we use this group ICA to extract several independent components (IC) corresponding to the sequence of activation and used single-trial peaks as modulation parameters in a general linear model (GLM) of fMRI data. We obtained an occipital-temporal-frontal stream of BOLD signal modulation, in accordance with the three successive IC-ERPs providing an unprecedented spatio-temporal characterization of the whole cognitive process as defined by BOLD signal modulation. By using this approach, the pattern of EEG-informed BOLD modulation provided improved characterization of the network involved than the fMRI-only analysis or the source reconstruction of the three ERPs; the latter techniques showing only two regions in common localized in the occipital lobe. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Predicting the start and maximum amplitude of solar cycle 24 using similar phases and a cycle grouping

    International Nuclear Information System (INIS)

    Wang Jialong; Zong Weiguo; Le Guiming; Zhao Haijuan; Tang Yunqiu; Zhang Yang

    2009-01-01

    We find that the solar cycles 9, 11, and 20 are similar to cycle 23 in their respective descending phases. Using this similarity and the observed data of smoothed monthly mean sunspot numbers (SMSNs) available for the descending phase of cycle 23, we make a date calibration for the average time sequence made of the three descending phases of the three cycles, and predict the start of March or April 2008 for cycle 24. For the three cycles, we also find a linear correlation of the length of the descending phase of a cycle with the difference between the maximum epoch of this cycle and that of its next cycle. Using this relationship along with the known relationship between the rise-time and the maximum amplitude of a slowly rising solar cycle, we predict the maximum SMSN of cycle 24 of 100.2 ± 7.5 to appear during the period from May to October 2012. (letters)

  13. Simultaneous measurement of the maximum oscillation amplitude and the transient decay time constant of the QCM reveals stiffness changes of the adlayer.

    Science.gov (United States)

    Marxer, C Galli; Coen, M Collaud; Bissig, H; Greber, U F; Schlapbach, L

    2003-10-01

    Interpretation of adsorption kinetics measured with a quartz crystal microbalance (QCM) can be difficult for adlayers undergoing modification of their mechanical properties. We have studied the behavior of the oscillation amplitude, A(0), and the decay time constant, tau, of quartz during adsorption of proteins and cells, by use of a home-made QCM. We are able to measure simultaneously the frequency, f, the dissipation factor, D, the maximum amplitude, A(0), and the transient decay time constant, tau, every 300 ms in liquid, gaseous, or vacuum environments. This analysis enables adsorption and modification of liquid/mass properties to be distinguished. Moreover the surface coverage and the stiffness of the adlayer can be estimated. These improvements promise to increase the appeal of QCM methodology for any applications measuring intimate contact of a dynamic material with a solid surface.

  14. Beware of Boldness

    National Research Council Canada - National Science Library

    Crane, Conrad C

    2006-01-01

    ... to be?"1 Army Field Manual 7.0, Training the Force, states that the goals of operational deployments and major training opportunities are to enhance unit readiness and "produce bold, innovative leaders...

  15. New approach of determinations of earthquake moment magnitude using near earthquake source duration and maximum displacement amplitude of high frequency energy radiation

    Energy Technology Data Exchange (ETDEWEB)

    Gunawan, H.; Puspito, N. T.; Ibrahim, G.; Harjadi, P. J. P. [ITB, Faculty of Earth Sciences and Tecnology (Indonesia); BMKG (Indonesia)

    2012-06-20

    The new approach method to determine the magnitude by using amplitude displacement relationship (A), epicenter distance ({Delta}) and duration of high frequency radiation (t) has been investigated for Tasikmalaya earthquake, on September 2, 2009, and their aftershock. Moment magnitude scale commonly used seismic surface waves with the teleseismic range of the period is greater than 200 seconds or a moment magnitude of the P wave using teleseismic seismogram data and the range of 10-60 seconds. In this research techniques have been developed a new approach to determine the displacement amplitude and duration of high frequency radiation using near earthquake. Determination of the duration of high frequency using half of period of P waves on the seismograms displacement. This is due tothe very complex rupture process in the near earthquake. Seismic data of the P wave mixing with other wave (S wave) before the duration runs out, so it is difficult to separate or determined the final of P-wave. Application of the 68 earthquakes recorded by station of CISI, Garut West Java, the following relationship is obtained: Mw = 0.78 log (A) + 0.83 log {Delta}+ 0.69 log (t) + 6.46 with: A (m), d (km) and t (second). Moment magnitude of this new approach is quite reliable, time processing faster so useful for early warning.

  16. New approach of determinations of earthquake moment magnitude using near earthquake source duration and maximum displacement amplitude of high frequency energy radiation

    Science.gov (United States)

    Gunawan, H.; Puspito, N. T.; Ibrahim, G.; Harjadi, P. J. P.

    2012-06-01

    The new approach method to determine the magnitude by using amplitude displacement relationship (A), epicenter distance (Δ) and duration of high frequency radiation (t) has been investigated for Tasikmalaya earthquake, on September 2, 2009, and their aftershock. Moment magnitude scale commonly used seismic surface waves with the teleseismic range of the period is greater than 200 seconds or a moment magnitude of the P wave using teleseismic seismogram data and the range of 10-60 seconds. In this research techniques have been developed a new approach to determine the displacement amplitude and duration of high frequency radiation using near earthquake. Determination of the duration of high frequency using half of period of P waves on the seismograms displacement. This is due tothe very complex rupture process in the near earthquake. Seismic data of the P wave mixing with other wave (S wave) before the duration runs out, so it is difficult to separate or determined the final of P-wave. Application of the 68 earthquakes recorded by station of CISI, Garut West Java, the following relationship is obtained: Mw = 0.78 log (A) + 0.83 log Δ + 0.69 log (t) + 6.46 with: A (m), d (km) and t (second). Moment magnitude of this new approach is quite reliable, time processing faster so useful for early warning.

  17. New approach of determinations of earthquake moment magnitude using near earthquake source duration and maximum displacement amplitude of high frequency energy radiation

    International Nuclear Information System (INIS)

    Gunawan, H.; Puspito, N. T.; Ibrahim, G.; Harjadi, P. J. P.

    2012-01-01

    The new approach method to determine the magnitude by using amplitude displacement relationship (A), epicenter distance (Δ) and duration of high frequency radiation (t) has been investigated for Tasikmalaya earthquake, on September 2, 2009, and their aftershock. Moment magnitude scale commonly used seismic surface waves with the teleseismic range of the period is greater than 200 seconds or a moment magnitude of the P wave using teleseismic seismogram data and the range of 10-60 seconds. In this research techniques have been developed a new approach to determine the displacement amplitude and duration of high frequency radiation using near earthquake. Determination of the duration of high frequency using half of period of P waves on the seismograms displacement. This is due tothe very complex rupture process in the near earthquake. Seismic data of the P wave mixing with other wave (S wave) before the duration runs out, so it is difficult to separate or determined the final of P-wave. Application of the 68 earthquakes recorded by station of CISI, Garut West Java, the following relationship is obtained: Mw = 0.78 log (A) + 0.83 log Δ+ 0.69 log (t) + 6.46 with: A (m), d (km) and t (second). Moment magnitude of this new approach is quite reliable, time processing faster so useful for early warning.

  18. Correlation between MEG and BOLD fMRI signals induced by visual flicker stimuli

    Institute of Scientific and Technical Information of China (English)

    Chu Renxin; Holroyd Tom; Duyn Jeff

    2007-01-01

    The goal of this work was to investigate how the MEG signal amplitude correlates with that of BOLD fMRI.To investigate the correlation between fMRI and macroscopic electrical activity, BOLD fMRI and MEG was performed on the same subjects (n =5). A visual flicker stimulus of varying temporal frequency was used to elicit neural responses in early visual areas. A strong similarity was observed in frequency tuning curves between both modalities.Although, averaged over subjects, the BOLD tuning curve was somewhat broader than MEG, both BOLD and MEG had maxima at a flicker frequency of 10 Hz. Also, we measured the first and second harmonic components as the stimuli frequency by MEG. In the low stimuli frequency (less than 6 Hz), the second harmonic has comparable amplitude with the first harmonic, which implies that neural frequency response is nonlinear and has more nonlinear components in low frequency than in high frequency.

  19. Generate the scale-free brain music from BOLD signals.

    Science.gov (United States)

    Lu, Jing; Guo, Sijia; Chen, Mingming; Wang, Weixia; Yang, Hua; Guo, Daqing; Yao, Dezhong

    2018-01-01

    Many methods have been developed to translate a human electroencephalogram (EEG) into music. In addition to EEG, functional magnetic resonance imaging (fMRI) is another method used to study the brain and can reflect physiological processes. In 2012, we established a method to use simultaneously recorded fMRI and EEG signals to produce EEG-fMRI music, which represents a step toward scale-free brain music. In this study, we used a neural mass model, the Jansen-Rit model, to simulate activity in several cortical brain regions. The interactions between different brain regions were represented by the average normalized diffusion tensor imaging (DTI) structural connectivity with a coupling coefficient that modulated the coupling strength. Seventy-eight brain regions were adopted from the Automated Anatomical Labeling (AAL) template. Furthermore, we used the Balloon-Windkessel hemodynamic model to transform neural activity into a blood-oxygen-level dependent (BOLD) signal. Because the fMRI BOLD signal changes slowly, we used a sampling rate of 250 Hz to produce the temporal series for music generation. Then, the BOLD music was generated for each region using these simulated BOLD signals. Because the BOLD signal is scale free, these music pieces were also scale free, which is similar to classic music. Here, to simulate the case of an epileptic patient, we changed the parameter that determined the amplitude of the excitatory postsynaptic potential (EPSP) in the neural mass model. Finally, we obtained BOLD music for healthy and epileptic patients. The differences in levels of arousal between the 2 pieces of music may provide a potential tool for discriminating the different populations if the differences can be confirmed by more real data. Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

  20. Acetazolamide-augmented dynamic BOLD (aczBOLD imaging for assessing cerebrovascular reactivity in chronic steno-occlusive disease of the anterior circulation: An initial experience

    Directory of Open Access Journals (Sweden)

    Junjie Wu

    2017-01-01

    Full Text Available The purpose of this study was to measure cerebrovascular reactivity (CVR in chronic steno-occlusive disease using a novel approach that couples BOLD imaging with acetazolamide (ACZ vasoreactivity (aczBOLD, to evaluate dynamic effects of ACZ on BOLD and to establish the relationship between aczBOLD and dynamic susceptibility contrast (DSC perfusion MRI. Eighteen patients with unilateral chronic steno-occlusive disease of the anterior circulation underwent a 20-min aczBOLD imaging protocol, with ACZ infusion starting at 5 min of scan initiation. AczBOLD reactivity was calculated on a voxel-by-voxel basis to generate CVR maps for subsequent quantitative analyses. Reduced CVR was observed in the diseased vs. the normal hemisphere both by qualitative and quantitative assessment (gray matter (GM: 4.13% ± 1.16% vs. 4.90% ± 0.98%, P = 0.002; white matter (WM: 2.83% ± 1.23% vs. 3.50% ± 0.94%, P = 0.005. In all cases BOLD signal began increasing immediately following ACZ infusion, approaching a plateau at ~8.5 min after infusion, with the tissue volume of reduced augmentation increasing progressively with time, peaking at 2.60 min (time range above 95% of the maximum value: 0–4.43 min for the GM and 1.80 min (time range above 95% of the maximum value: 1.40–3.53 min for the WM. In the diseased hemisphere, aczBOLD CVR significantly correlated with baseline DSC time-to-maximum of the residue function (Tmax (P = 0.008 for the WM and normalized cerebral blood flow (P = 0.003 for the GM, and P = 0.001 for the WM. AczBOLD provides a novel, safe, easily implementable approach to CVR measurement in the routine clinical environments. Further studies can establish quantitative thresholds from aczBOLD towards identification of patients at heightened risk of recurrent ischemia and cognitive decline.

  1. Caffeine reduces resting-state BOLD functional connectivity in the motor cortex.

    Science.gov (United States)

    Rack-Gomer, Anna Leigh; Liau, Joy; Liu, Thomas T

    2009-05-15

    In resting-state functional magnetic resonance imaging (fMRI), correlations between spontaneous low-frequency fluctuations in the blood oxygenation level dependent (BOLD) signal are used to assess functional connectivity between different brain regions. Changes in resting-state BOLD connectivity measures are typically interpreted as changes in coherent neural activity across spatially distinct brain regions. However, this interpretation can be complicated by the complex dependence of the BOLD signal on both neural and vascular factors. For example, prior studies have shown that vasoactive agents that alter baseline cerebral blood flow, such as caffeine and carbon dioxide, can significantly alter the amplitude and dynamics of the task-related BOLD response. In this study, we examined the effect of caffeine (200 mg dose) on resting-state BOLD connectivity in the motor cortex across a sample of healthy young subjects (N=9). We found that caffeine significantly (pcaffeine. These results suggest that caffeine usage should be carefully considered in the design and interpretation of resting-state BOLD fMRI studies.

  2. "Extreme Bold" in the Faculty Ranks

    Science.gov (United States)

    Kuusisto, Stephen

    2013-01-01

    Boldness, defense, and the necessity of talking back remain as central to life with disability in one's time as in Francis Bacon's age. "Therefore all deformed persons are extreme bold," Bacon wrote, "first, as in their own defence, as being exposed to scorn, but in process of time, by a general habit." Perhaps no word carries…

  3. Cortical Network Models of Firing Rates in the Resting and Active States Predict BOLD Responses.

    Directory of Open Access Journals (Sweden)

    Maxwell R Bennett

    Full Text Available Measurements of blood oxygenation level dependent (BOLD signals have produced some surprising observations. One is that their amplitude is proportional to the entire activity in a region of interest and not just the fluctuations in this activity. Another is that during sleep and anesthesia the average BOLD correlations between regions of interest decline as the activity declines. Mechanistic explanations of these phenomena are described here using a cortical network model consisting of modules with excitatory and inhibitory neurons, taken as regions of cortical interest, each receiving excitatory inputs from outside the network, taken as subcortical driving inputs in addition to extrinsic (intermodular connections, such as provided by associational fibers. The model shows that the standard deviation of the firing rate is proportional to the mean frequency of the firing when the extrinsic connections are decreased, so that the mean BOLD signal is proportional to both as is observed experimentally. The model also shows that if these extrinsic connections are decreased or the frequency of firing reaching the network from the subcortical driving inputs is decreased, or both decline, there is a decrease in the mean firing rate in the modules accompanied by decreases in the mean BOLD correlations between the modules, consistent with the observed changes during NREM sleep and under anesthesia. Finally, the model explains why a transient increase in the BOLD signal in a cortical area, due to a transient subcortical input, gives rises to responses throughout the cortex as observed, with these responses mediated by the extrinsic (intermodular connections.

  4. A NO way to BOLD?

    DEFF Research Database (Denmark)

    Aamand, Rasmus; Dalsgaard, Thomas; Ho, Yi Ching Lynn

    2013-01-01

    Neurovascular coupling links neuronal activity to vasodilation. Nitric oxide (NO) is a potent vasodilator, and in neurovascular coupling NO production from NO synthases plays an important role. However, another pathway for NO production also exists, namely the nitrate-nitrite-NO pathway. On this ......Neurovascular coupling links neuronal activity to vasodilation. Nitric oxide (NO) is a potent vasodilator, and in neurovascular coupling NO production from NO synthases plays an important role. However, another pathway for NO production also exists, namely the nitrate-nitrite-NO pathway...... to stimuli. A faster and smaller BOLD response, with less variation across local cortex, is consistent with an enhanced hemodynamic coupling during elevated nitrate intake. These findings suggest that dietary patterns, via the nitrate-nitrite-NO pathway, may be a potential way to affect key properties....... On this basis, we hypothesized that dietary nitrate (NO3-) could influence the brain's hemodynamic response to neuronal stimulation. In the present study, 20 healthy male participants were given either sodium nitrate (NaNO3) or sodium chloride (NaCl) (saline placebo) in a crossover study and were shown visual...

  5. Efeito da amplitude de movimento no número máximo de repetições no exercício supino livre Efectos de la amplitud de movimiento em el número máximo de repeticiones em el ejercicio de supino libre Effect of range of motion in the maximum number of repetitions in the bench press exercise

    Directory of Open Access Journals (Sweden)

    Fernando Vitor Lima

    2012-12-01

    Full Text Available Pesquisas mostram resultados divergentes no aumento da força utilizando diferentes amplitudes de movimento (ADM. O objetivo deste estudo foi comparar o número máximo de repetições (NMR no exercício supino com duas ADM. Quatorze voluntários realizaram a familiarização e o teste de uma repetição máxima (1 RM nas sessões 1 e 2. Nas sessões 3 e 4 realizaram o NMR em quatro séries a 50% de 1 RM, com um minuto de pausa, com ADM parcial (ADMP e completa (ADMC. Na ADMP utilizou-se metade do deslocamento vertical da barra comparada a condição ADMC. Foi realizada ANOVA "two-way" com medidas repetidas, seguida pelo "Post hoc" Scheffé. Houve diminuição significante do NMR entre as séries, exceto da terceira para a quarta em ambas ADM. Um maior NMR foi verificado para ADMP. A redução da ADM permite a realização de um maior número de repetições para uma mesma intensidade relativa.Investigaciones cientificas muestran resultados divergentes en el aumento de la fuerza utilizando diferentes amplitudes de movimiento (ADM. El objetivo de este estudio fue comparar el número máximo de repeticiones (NMR en un ejercicio de supino con dos ADM. Catorce voluntarios realizaron la familiarización y el test de una repetición máxima (1 RM en las sesiones 1 y 2. En las sesiones 3 y 4 realizaron o NMR en cuatro series a 50% de 1 RM, un minuto de pausa con ADM parcial (ADMP y completa (ADMC. ADMP utilizó la mitad del desplazamiento vertical de la barra realizado durante la ADMC. Fue aplicada ANOVA "two-way" con medidas repetidas, seguido del "Post hoc" Scheffé. Se encontró disminución significante del NMR a lo largo de las series, excepto de la tercera para la cuarta en ambas ADM, con el mismo patrón de reducción en ambas ADM. El NMR de la ADMP fue mayor que la ADMC. La reducción de ADM interfirió en el volumen de entrenamiento con mayor número de repeticiones realizadas para una misma intensidad relativa.There are divergent results

  6. Right anterior cerebellum BOLD responses reflect age related changes in Simon task sequential effects.

    Science.gov (United States)

    Aisenberg, D; Sapir, A; Close, A; Henik, A; d'Avossa, G

    2018-01-31

    Participants are slower to report a feature, such as color, when the target appears on the side opposite the instructed response, than when the target appears on the same side. This finding suggests that target location, even when task-irrelevant, interferes with response selection. This effect is magnified in older adults. Lengthening the inter-trial interval, however, suffices to normalize the congruency effect in older adults, by re-establishing young-like sequential effects (Aisenberg et al., 2014). We examined the neurological correlates of age related changes by comparing BOLD signals in young and old participants performing a visual version of the Simon task. Participants reported the color of a peripheral target, by a left or right-hand keypress. Generally, BOLD responses were greater following incongruent than congruent targets. Also, they were delayed and of smaller amplitude in old than young participants. BOLD responses in visual and motor regions were also affected by the congruency of the previous target, suggesting that sequential effects may reflect remapping of stimulus location onto the hand used to make a response. Crucially, young participants showed larger BOLD responses in right anterior cerebellum to incongruent targets, when the previous target was congruent, but smaller BOLD responses to incongruent targets when the previous target was incongruent. Old participants, however, showed larger BOLD responses to congruent than incongruent targets, irrespective of the previous target congruency. We conclude that aging may interfere with the trial by trial updating of the mapping between the task-irrelevant target location and response, which takes place during the inter-trial interval in the cerebellum and underlays sequential effects in a Simon task. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Decreased BOLD responses in audiovisual processing

    NARCIS (Netherlands)

    Wiersinga-Post, Esther; Tomaskovic, Sonja; Slabu, Lavinia; Renken, Remco; de Smit, Femke; Duifhuis, Hendrikus

    2010-01-01

    Audiovisual processing was studied in a functional magnetic resonance imaging study using the McGurk effect. Perceptual responses and the brain activity patterns were measured as a function of audiovisual delay. In several cortical and subcortical brain areas, BOLD responses correlated negatively

  8. Searching for Conservation Laws in Brain Dynamics—BOLD Flux and Source Imaging

    Directory of Open Access Journals (Sweden)

    Henning U. Voss

    2014-07-01

    Full Text Available Blood-oxygen-level-dependent (BOLD imaging is the most important noninvasive tool to map human brain function. It relies on local blood-flow changes controlled by neurovascular coupling effects, usually in response to some cognitive or perceptual task. In this contribution we ask if the spatiotemporal dynamics of the BOLD signal can be modeled by a conservation law. In analogy to the description of physical laws, which often can be derived from some underlying conservation law, identification of conservation laws in the brain could lead to new models for the functional organization of the brain. Our model is independent of the nature of the conservation law, but we discuss possible hints and motivations for conservation laws. For example, globally limited blood supply and local competition between brain regions for blood might restrict the large scale BOLD signal in certain ways that could be observable. One proposed selective pressure for the evolution of such conservation laws is the closed volume of the skull limiting the expansion of brain tissue by increases in blood volume. These ideas are demonstrated on a mental motor imagery fMRI experiment, in which functional brain activation was mapped in a group of volunteers imagining themselves swimming. In order to search for local conservation laws during this complex cognitive process, we derived maps of quantities resulting from spatial interaction of the BOLD amplitudes. Specifically, we mapped fluxes and sources of the BOLD signal, terms that would appear in a description by a continuity equation. Whereas we cannot present final answers with the particular analysis of this particular experiment, some results seem to be non-trivial. For example, we found that during task the group BOLD flux covered more widespread regions than identified by conventional BOLD mapping and was always increasing during task. It is our hope that these results motivate more work towards the search for conservation

  9. BOLD magnetic resonance imaging in nephrology

    Science.gov (United States)

    Hall, Michael E; Jordan, Jennifer H; Juncos, Luis A; Hundley, W Gregory; Hall, John E

    2018-01-01

    Magnetic resonance (MR) imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Therefore, development of non-contrast techniques to study kidney anatomy and physiology is important. Blood oxygen level-dependent (BOLD) MR is a non-contrast imaging technique that provides functional information related to renal tissue oxygenation in various pathophysiologic conditions. Here we discuss technical considerations, clinical uses and future directions for use of BOLD MR as well as complementary MR techniques to better understand renal pathophysiology. Our intent is to summarize kidney BOLD MR applications for the clinician rather than focusing on the complex physical challenges that functional MR imaging encompasses; however, we briefly discuss some of those issues. PMID:29559807

  10. BOLD magnetic resonance imaging in nephrology

    Directory of Open Access Journals (Sweden)

    Hall ME

    2018-03-01

    Full Text Available Michael E Hall,1,2 Jennifer H Jordan,3 Luis A Juncos,1,2 W Gregory Hundley,3 John E Hall2 1Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA; 2Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA; 3Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: Magnetic resonance (MR imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Therefore, development of non-contrast techniques to study kidney anatomy and physiology is important. Blood oxygen level-dependent (BOLD MR is a non-contrast imaging technique that provides functional information related to renal tissue oxygenation in various pathophysiologic conditions. Here we discuss technical considerations, clinical uses and future directions for use of BOLD MR as well as complementary MR techniques to better understand renal pathophysiology. Our intent is to summarize kidney BOLD MR applications for the clinician rather than focusing on the complex physical challenges that functional MR imaging encompasses; however, we briefly discuss some of those issues. Keywords: functional MRI, kidney, oxygenation, chronic kidney disease 

  11. BOLD Granger causality reflects vascular anatomy.

    Directory of Open Access Journals (Sweden)

    J Taylor Webb

    Full Text Available A number of studies have tried to exploit subtle phase differences in BOLD time series to resolve the order of sequential activation of brain regions, or more generally the ability of signal in one region to predict subsequent signal in another region. More recently, such lag-based measures have been applied to investigate directed functional connectivity, although this application has been controversial. We attempted to use large publicly available datasets (FCON 1000, ADHD 200, Human Connectome Project to determine whether consistent spatial patterns of Granger Causality are observed in typical fMRI data. For BOLD datasets from 1,240 typically developing subjects ages 7-40, we measured Granger causality between time series for every pair of 7,266 spherical ROIs covering the gray matter and 264 seed ROIs at hubs of the brain's functional network architecture. Granger causality estimates were strongly reproducible for connections in a test and replication sample (n=620 subjects for each group, as well as in data from a single subject scanned repeatedly, both during resting and passive video viewing. The same effect was even stronger in high temporal resolution fMRI data from the Human Connectome Project, and was observed independently in data collected during performance of 7 task paradigms. The spatial distribution of Granger causality reflected vascular anatomy with a progression from Granger causality sources, in Circle of Willis arterial inflow distributions, to sinks, near large venous vascular structures such as dural venous sinuses and at the periphery of the brain. Attempts to resolve BOLD phase differences with Granger causality should consider the possibility of reproducible vascular confounds, a problem that is independent of the known regional variability of the hemodynamic response.

  12. Early anti-correlated BOLD signal changes of physiologic origin.

    Science.gov (United States)

    Bright, Molly G; Bianciardi, Marta; de Zwart, Jacco A; Murphy, Kevin; Duyn, Jeff H

    2014-02-15

    Negative BOLD signals that are synchronous with resting state fluctuations have been observed in large vessels in the cortical sulci and surrounding the ventricles. In this study, we investigated the origin of these negative BOLD signals by applying a Cued Deep Breathing (CDB) task to create transient hypocapnia and a resultant global fMRI signal decrease. We hypothesized that a global stimulus would amplify the effect in large vessels and that using a global negative (vasoconstrictive) stimulus would test whether these voxels exhibit either inherently negative or simply anti-correlated BOLD responses. Significantly anti-correlated, but positive, BOLD signal changes during respiratory challenges were identified in voxels primarily located near edges of brain spaces containing CSF. These positive BOLD responses occurred earlier than the negative CDB response across most of gray matter voxels. These findings confirm earlier suggestions that in some brain regions, local, fractional changes in CSF volume may overwhelm BOLD-related signal changes, leading to signal anti-correlation. We show that regions with CDB anti-correlated signals coincide with most, but not all, of the regions with negative BOLD signal changes observed during a visual and motor stimulus task. Thus, the addition of a physiological challenge to fMRI experiments can help identify which negative BOLD signals are passive physiological anti-correlations and which may have a putative neuronal origin. Published by Elsevier Inc.

  13. Implications of oxidative stress in the brain plasticity originated by fasting: a BOLD-fMRI study.

    Science.gov (United States)

    Belaïch, Rachida; Boujraf, Saïd; Benzagmout, Mohammed; Magoul, Rabia; Maaroufi, Mustapha; Tizniti, Siham

    2017-11-01

    and the maximum intensity of BOLD signal in the activated area M1 was determined for all studied volunteers. The current study allowed measuring regional brain volumes and neural network activity before and during an extended period of fasting using BOLD-fMRI. This demonstrated and confirmed the impact of fasting on human brain structure and function. Further studies are required to elucidate mechanisms and enable direct inference of a diet-induced OS effect on the brain.

  14. Differentiating BOLD and non-BOLD signals in fMRI time series using multi-echo EPI.

    Science.gov (United States)

    Kundu, Prantik; Inati, Souheil J; Evans, Jennifer W; Luh, Wen-Ming; Bandettini, Peter A

    2012-04-15

    A central challenge in the fMRI based study of functional connectivity is distinguishing neuronally related signal fluctuations from the effects of motion, physiology, and other nuisance sources. Conventional techniques for removing nuisance effects include modeling of noise time courses based on external measurements followed by temporal filtering. These techniques have limited effectiveness. Previous studies have shown using multi-echo fMRI that neuronally related fluctuations are Blood Oxygen Level Dependent (BOLD) signals that can be characterized in terms of changes in R(2)* and initial signal intensity (S(0)) based on the analysis of echo-time (TE) dependence. We hypothesized that if TE-dependence could be used to differentiate BOLD and non-BOLD signals, non-BOLD signal could be removed to denoise data without conventional noise modeling. To test this hypothesis, whole brain multi-echo data were acquired at 3 TEs and decomposed with Independent Components Analysis (ICA) after spatially concatenating data across space and TE. Components were analyzed for the degree to which their signal changes fit models for R(2)* and S(0) change, and summary scores were developed to characterize each component as BOLD-like or not BOLD-like. These scores clearly differentiated BOLD-like "functional network" components from non BOLD-like components related to motion, pulsatility, and other nuisance effects. Using non BOLD-like component time courses as noise regressors dramatically improved seed-based correlation mapping by reducing the effects of high and low frequency non-BOLD fluctuations. A comparison with seed-based correlation mapping using conventional noise regressors demonstrated the superiority of the proposed technique for both individual and group level seed-based connectivity analysis, especially in mapping subcortical-cortical connectivity. The differentiation of BOLD and non-BOLD components based on TE-dependence was highly robust, which allowed for the

  15. Multi-regional investigation of the relationship between functional MRI blood oxygenation level dependent (BOLD activation and GABA concentration.

    Directory of Open Access Journals (Sweden)

    Ashley D Harris

    Full Text Available Several recent studies have reported an inter-individual correlation between regional GABA concentration, as measured by MRS, and the amplitude of the functional blood oxygenation level dependent (BOLD response in the same region. In this study, we set out to investigate whether this coupling generalizes across cortex. In 18 healthy participants, we performed edited MRS measurements of GABA and BOLD-fMRI experiments using regionally related activation paradigms. Regions and tasks were the: occipital cortex with a visual grating stimulus; auditory cortex with a white noise stimulus; sensorimotor cortex with a finger-tapping task; frontal eye field with a saccade task; and dorsolateral prefrontal cortex with a working memory task. In contrast to the prior literature, no correlation between GABA concentration and BOLD activation was detected in any region. The origin of this discrepancy is not clear. Subtle differences in study design or insufficient power may cause differing results; these and other potential reasons for the discrepant results are discussed. This negative result, although it should be interpreted with caution, has a larger sample size than prior positive results, and suggests that the relationship between GABA and the BOLD response may be more complex than previously thought.

  16. Cortical layers, rhythms and BOLD signals.

    Science.gov (United States)

    Scheeringa, René; Fries, Pascal

    2017-11-03

    This review investigates how laminar fMRI can complement insights into brain function derived from the study of rhythmic neuronal synchronization. Neuronal synchronization in various frequency bands plays an important role in neuronal communication between brain areas, and it does so on the backbone of layer-specific interareal anatomical projections. Feedforward projections originate predominantly in supragranular cortical layers and terminate in layer 4, and this pattern is reflected in inter-laminar and interareal directed gamma-band influences. Thus, gamma-band synchronization likely subserves feedforward signaling. By contrast, anatomical feedback projections originate predominantly in infragranular layers and terminate outside layer 4, and this pattern is reflected in inter-laminar and interareal directed alpha- and/or beta-band influences. Thus, alpha-beta band synchronization likely subserves feedback signaling. Furthermore, these rhythms explain part of the BOLD signal, with independent contributions of alpha-beta and gamma. These findings suggest that laminar fMRI can provide us with a potentially useful method to test some of the predictions derived from the study of neuronal synchronization. We review central findings regarding the role of layer-specific neuronal synchronization for brain function, and regarding the link between neuronal synchronization and the BOLD signal. We discuss the role that laminar fMRI could play by comparing it to invasive and non-invasive electrophysiological recordings. Compared to direct electrophysiological recordings, this method provides a metric of neuronal activity that is slow and indirect, but that is uniquely non-invasive and layer-specific with potentially whole brain coverage. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Sustained negative BOLD response in human fMRI finger tapping task.

    Directory of Open Access Journals (Sweden)

    Yadong Liu

    Full Text Available In this work, we investigated the sustained negative blood oxygen level-dependent (BOLD response (sNBR using functional magnetic resonance imaging during a finger tapping task. We observed that the sNBR for this task was more extensive than has previously been reported. The cortical regions involved in sNBR are divided into the following three groups: frontal, somatosensory and occipital. By investigating the spatial structure, area, amplitude, and dynamics of the sNBR in comparison with those of its positive BOLD response (PBR counterpart, we made the following observations. First, among the three groups, the somatosensory group contained the greatest number of activated voxels and the fewest deactivated voxels. In addition, the amplitude of the sNBR in this group was the smallest among the three groups. Second, the onset and peak time of the sNBR are both larger than those of the PBR, whereas the falling edge time of the sNBR is less than that of the PBR. Third, the long distance between most sNBR foci and their corresponding PBR foci makes it unlikely that they share the same blood supply artery. Fourth, the couplings between the sNBR and its PBR counterpart are distinct among different regions and thus should be investigated separately. These findings imply that the origin of most sNBR foci in the finger-tapping task is much more likely to be neuronal activity suppression rather than "blood steal."

  18. Sustained negative BOLD response in human fMRI finger tapping task.

    Science.gov (United States)

    Liu, Yadong; Shen, Hui; Zhou, Zongtan; Hu, Dewen

    2011-01-01

    In this work, we investigated the sustained negative blood oxygen level-dependent (BOLD) response (sNBR) using functional magnetic resonance imaging during a finger tapping task. We observed that the sNBR for this task was more extensive than has previously been reported. The cortical regions involved in sNBR are divided into the following three groups: frontal, somatosensory and occipital. By investigating the spatial structure, area, amplitude, and dynamics of the sNBR in comparison with those of its positive BOLD response (PBR) counterpart, we made the following observations. First, among the three groups, the somatosensory group contained the greatest number of activated voxels and the fewest deactivated voxels. In addition, the amplitude of the sNBR in this group was the smallest among the three groups. Second, the onset and peak time of the sNBR are both larger than those of the PBR, whereas the falling edge time of the sNBR is less than that of the PBR. Third, the long distance between most sNBR foci and their corresponding PBR foci makes it unlikely that they share the same blood supply artery. Fourth, the couplings between the sNBR and its PBR counterpart are distinct among different regions and thus should be investigated separately. These findings imply that the origin of most sNBR foci in the finger-tapping task is much more likely to be neuronal activity suppression rather than "blood steal."

  19. Fitness Consequences of Boldness in Juvenile and Adult Largemouth Bass.

    Science.gov (United States)

    Ballew, Nicholas G; Mittelbach, Gary G; Scribner, Kim T

    2017-04-01

    To date, most studies investigating the relationship between personality traits and fitness have focused on a single measure of fitness (such as survival) at a specific life stage. However, many personality traits likely have multiple effects on fitness, potentially operating across different functional contexts and stages of development. Here, we address the fitness consequences of boldness, under seminatural conditions, across life stages and functional contexts in largemouth bass (Micropterus salmoides). Specifically, we report the effect of boldness on (1) juvenile survivorship in an outdoor pond containing natural prey and predators and (2) adult reproductive success in three outdoor ponds across three reproductive seasons (years). Juvenile survival was negatively affected by boldness, with bolder juveniles having a lower probability of survival than shyer juveniles. In contrast, bolder adult male bass had greater reproductive success than their shyer male counterparts. Female reproductive success was not affected by boldness. These findings demonstrate that boldness can affect fitness differently across life stages. Further, boldness was highly consistent across years and significantly heritable, which suggests that boldness has a genetic component. Thus, our results support theory suggesting that fitness trade-offs across life stages may contribute to the maintenance of personality variation within populations.

  20. Anatomical and functional assemblies of brain BOLD oscillations

    Science.gov (United States)

    Baria, Alexis T.; Baliki, Marwan N.; Parrish, Todd; Apkarian, A. Vania

    2011-01-01

    Brain oscillatory activity has long been thought to have spatial properties, the details of which are unresolved. Here we examine spatial organizational rules for the human brain oscillatory activity as measured by blood oxygen level-dependent (BOLD). Resting state BOLD signal was transformed into frequency space (Welch’s method), averaged across subjects, and its spatial distribution studied as a function of four frequency bands, spanning the full bandwidth of BOLD. The brain showed anatomically constrained distribution of power for each frequency band. This result was replicated on a repository dataset of 195 subjects. Next, we examined larger-scale organization by parceling the neocortex into regions approximating Brodmann Areas (BAs). This indicated that BAs of simple function/connectivity (unimodal), vs. complex properties (transmodal), are dominated by low frequency BOLD oscillations, and within the visual ventral stream we observe a graded shift of power to higher frequency bands for BAs further removed from the primary visual cortex (increased complexity), linking frequency properties of BOLD to hodology. Additionally, BOLD oscillation properties for the default mode network demonstrated that it is composed of distinct frequency dependent regions. When the same analysis was performed on a visual-motor task, frequency-dependent global and voxel-wise shifts in BOLD oscillations could be detected at brain sites mostly outside those identified with general linear modeling. Thus, analysis of BOLD oscillations in full bandwidth uncovers novel brain organizational rules, linking anatomical structures and functional networks to characteristic BOLD oscillations. The approach also identifies changes in brain intrinsic properties in relation to responses to external inputs. PMID:21613505

  1. On the maximum amplitude of harmonics of an asteroid lightcurve

    Czech Academy of Sciences Publication Activity Database

    Harris, A. W.; Pravec, Petr; Galád, Adrián; Skiff, B.A.; Warner, B. D.; Világi, J.; Gajdoš, Š.; Carbognani, A.; Hornoch, Kamil; Kušnirák, Peter; Cooney jr., W. R.; Gross, J.; Terrell, D.; Higgins, D.; Bowell, E.; Koehn, B.W.

    2014-01-01

    Roč. 235, June (2014), s. 55-59 ISSN 0019-1035 R&D Projects: GA ČR GAP209/12/0229 Grant - others:SAV(SK) Vega 1/0670/13; NASA (US) NNX13AP56G Institutional support: RVO:67985815 Keywords : asteroids * asteroids rotation * photometry Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 3.038, year: 2014

  2. Blood oxygenation level dependent (BOLD). Renal imaging. Concepts and applications

    International Nuclear Information System (INIS)

    Nissen, Johanna C.; Haneder, Stefan; Schoenberg, Stefan O.; Michaely, Henrik J.

    2010-01-01

    Many renal diseases as well as several pharmacons cause a change in renal blood flow and/or renal oxygenation. The blood oxygenation level dependent (BOLD) imaging takes advantage of local field inhomogeneities and is based on a T2 * -weighted sequence. BOLD is a non-invasive method allowing an estimation of the renal, particularly the medullary oxygenation, and an indirect measurement of blood flow without administration of contrast agents. Thus, effects of different drugs on the kidney and various renal diseases can be controlled and observed. This work will provide an overview of the studies carried out so far and identify ways how BOLD can be used in clinical studies. (orig.)

  3. Diphoton generalized distribution amplitudes

    International Nuclear Information System (INIS)

    El Beiyad, M.; Pire, B.; Szymanowski, L.; Wallon, S.

    2008-01-01

    We calculate the leading order diphoton generalized distribution amplitudes by calculating the amplitude of the process γ*γ→γγ in the low energy and high photon virtuality region at the Born order and in the leading logarithmic approximation. As in the case of the anomalous photon structure functions, the γγ generalized distribution amplitudes exhibit a characteristic lnQ 2 behavior and obey inhomogeneous QCD evolution equations.

  4. The Rule of Three for Prizes in Science and the Bold Triptychs of Francis Bacon.

    Science.gov (United States)

    Goldstein, Joseph L

    2016-09-22

    For many scientific awards, such as Nobels and Laskers, the maximum number of recipients is three. This Rule of Three forces selection committees to make difficult decisions that increase the likelihood of singling out those individuals who open a new field and continue to lead it. The Rule of Three is reminiscent of art's three-panel triptych, a form that the modern master Francis Bacon used to distill complex stories in a bold way. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. To be so bold: boldness is repeatable and related to within individual behavioural variability in North Island robins.

    Science.gov (United States)

    He, Ruchuan; Pagani-Núñez, Emilio; Chevallier, Clément; Barnett, Craig R A

    2017-07-01

    Behavioural research traditionally focusses on the mean responses of a group of individuals rather than variation in behaviour around the mean or among individuals. However, examining the variation in behaviour among and within individuals may also yield important insights into the evolution and maintenance of behaviour. Repeatability is the most commonly used measure of variability among individuals in behavioural research. However, there are other forms of variation within populations that have received less attention. One such measure is intraindividual variation in behaviour (IIV), which is a short-term fluctuation of within-individual behaviour. Such variation in behaviour might be important during interactions because it could decrease the ability of conspecific and heterospecific individuals to predict the behaviour of the subject, thus increasing the cost of the interaction. In this experiment, we made repeated measures of the latency of North Island robins to attack a prey in a novel situation (a form of boldness) and examined (i) repeatability of boldness (the propensity to take a risk), (ii) IIV of boldness, and (iii) whether there was a significant relationship between these two traits (a behavioural syndrome). We found that boldness was highly repeatable, that there were high levels of IIV in boldness, and that there was a negative relationship between boldness and IIV in boldness. This suggests that despite high levels of repeatability for this behaviour, there were also still significant differences in IIV among different individuals within the population. Moreover, bolder individuals had significantly less IIV in their boldness, which suggests that they were forming routines (which reduces behavioural variability) compared to shyer individuals. Our results definitively demonstrate that IIV itself varies across individuals and is linked with key behavioural traits, and we argue for the importance of future studies aimed at understanding its causes

  6. Food intake rates of inactive fish are positively linked to boldness in three‐spined sticklebacks Gasterosteus aculeatus

    Science.gov (United States)

    Manica, A.; Boogert, N. J.

    2016-01-01

    To investigate the link between personality and maximum food intake of inactive individuals, food‐deprived three‐spined sticklebacks Gasterosteus aculeatus at rest in their home compartments were provided with ad libitum prey items. Bolder individuals ate considerably more than shyer individuals, even after accounting for body size, while sociability did not have an effect. These findings support pace‐of‐life theory predicting that life‐history strategies are linked to boldness. PMID:26940195

  7. Two Photon Distribution Amplitudes

    International Nuclear Information System (INIS)

    El Beiyad, M.; Pire, B.; Szymanowski, L.; Wallon, S.

    2008-01-01

    The factorization of the amplitude of the process γ*γ→γγ in the low energy and high photon virtuality region is demonstrated at the Born order and in the leading logarithmic approximation. The leading order two photon (generalized) distribution amplitudes exhibit a characteristic ln Q 2 behaviour and obey new inhomogeneous evolution equations

  8. Amplitudes, acquisition and imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bloor, Robert

    1998-12-31

    Accurate seismic amplitude information is important for the successful evaluation of many prospects and the importance of such amplitude information is increasing with the advent of time lapse seismic techniques. It is now widely accepted that the proper treatment of amplitudes requires seismic imaging in the form of either time or depth migration. A key factor in seismic imaging is the spatial sampling of the data and its relationship to the imaging algorithms. This presentation demonstrates that acquisition caused spatial sampling irregularity can affect the seismic imaging and perturb amplitudes. Equalization helps to balance the amplitudes, and the dealing strategy improves the imaging further when there are azimuth variations. Equalization and dealiasing can also help with the acquisition irregularities caused by shot and receiver dislocation or missing traces. 2 refs., 2 figs.

  9. Color guided amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Broedel, Johannes [Stanford Institute for Theoretical Physics and Department of Physics, Stanford University, Stanford, CA (United States); Dixon, Lance J. [SLAC National Accelerator Laboratory, Stanford University, Stanford, CA (United States)

    2012-07-01

    Amplitudes in gauge thoeries obtain contributions from color and kinematics. While these two parts of the amplitude seem to exhibit different symmetry structures, it turns out that they can be reorganized in a way to behave equally, which leads to the so-called color-kinematic dual representations of amplitudes. Astonishingly, the existence of those representations allows squaring to related gravitational theories right away. Contrary to the Kawaii-Levellen-Tye relations, which have been used to relate gauge theories and gravity previously, this method is applicable not only to tree amplitudes but also at loop level. In this talk, the basic technique is introduced followed by a discussion of the existence of color-kinematic dual representations for amplitudes derived from gauge theory actions which are deformed by higher-operator insertions. In addition, it is commented on the implications for deformed gravitational theories.

  10. Task-Related Modulations of BOLD Low-Frequency Fluctuations within the Default Mode Network

    Directory of Open Access Journals (Sweden)

    Silvia Tommasin

    2017-07-01

    Full Text Available Spontaneous low-frequency Blood-Oxygenation Level-Dependent (BOLD signals acquired during resting state are characterized by spatial patterns of synchronous fluctuations, ultimately leading to the identification of robust brain networks. The resting-state brain networks, including the Default Mode Network (DMN, are demonstrated to persist during sustained task execution, but the exact features of task-related changes of network properties are still not well characterized. In this work we sought to examine in a group of 20 healthy volunteers (age 33 ± 6 years, 8 F/12 M the relationship between changes of spectral and spatiotemporal features of one prominent resting-state network, namely the DMN, during the continuous execution of a working memory n-back task. We found that task execution impacted on both functional connectivity and amplitude of BOLD fluctuations within large parts of the DMN, but these changes correlated between each other only in a small area of the posterior cingulate. We conclude that combined analysis of multiple parameters related to connectivity, and their changes during the transition from resting state to continuous task execution, can contribute to a better understanding of how brain networks rearrange themselves in response to a task.

  11. Task-Related Modulations of BOLD Low-Frequency Fluctuations within the Default Mode Network

    Science.gov (United States)

    Tommasin, Silvia; Mascali, Daniele; Gili, Tommaso; Assan, Ibrahim Eid; Moraschi, Marta; Fratini, Michela; Wise, Richard G.; Macaluso, Emiliano; Mangia, Silvia; Giove, Federico

    2017-01-01

    Spontaneous low-frequency Blood-Oxygenation Level-Dependent (BOLD) signals acquired during resting state are characterized by spatial patterns of synchronous fluctuations, ultimately leading to the identification of robust brain networks. The resting-state brain networks, including the Default Mode Network (DMN), are demonstrated to persist during sustained task execution, but the exact features of task-related changes of network properties are still not well characterized. In this work we sought to examine in a group of 20 healthy volunteers (age 33 ± 6 years, 8 F/12 M) the relationship between changes of spectral and spatiotemporal features of one prominent resting-state network, namely the DMN, during the continuous execution of a working memory n-back task. We found that task execution impacted on both functional connectivity and amplitude of BOLD fluctuations within large parts of the DMN, but these changes correlated between each other only in a small area of the posterior cingulate. We conclude that combined analysis of multiple parameters related to connectivity, and their changes during the transition from resting state to continuous task execution, can contribute to a better understanding of how brain networks rearrange themselves in response to a task. PMID:28845420

  12. Task-related modulations of BOLD low-frequency fluctuations within the default mode network

    Science.gov (United States)

    Tommasin, Silvia; Mascali, Daniele; Gili, Tommaso; Eid Assan, Ibrahim; Moraschi, Marta; Fratini, Michela; Wise, Richard G.; Macaluso, Emiliano; Mangia, Silvia; Giove, Federico

    2017-07-01

    Spontaneous low-frequency Blood-Oxygenation Level-Dependent (BOLD) signals acquired during resting state are characterized by spatial patterns of synchronous fluctuations, ultimately leading to the identification of robust brain networks. The resting-state brain networks, including the Default Mode Network (DMN), are demonstrated to persist during sustained task execution, but the exact features of task-related changes of network properties are still not well characterized. In this work we sought to examine in a group of 20 healthy volunteers (age 33±6 years, 8F/12M) the relationship between changes of spectral and spatiotemporal features of one prominent resting-state network, namely the DMN, during the steady-state execution of a sustained working memory n-back task. We found that the steady state execution of such a task impacted on both functional connectivity and amplitude of BOLD fluctuations within large parts of the DMN, but these changes correlated between each other only in a small area of the posterior cingulate. We conclude that combined analysis of multiple parameters related to connectivity, and their changes during the transition from resting state to steady-state task execution, can contribute to a better understanding of how brain networks rearrange themselves in response of a task.

  13. Towards prognostic biomarkers from BOLD fluctuations to differentiate a first epileptic seizure from new-onset epilepsy.

    Science.gov (United States)

    Gupta, Lalit; Janssens, Rick; Vlooswijk, Mariëlle C G; Rouhl, Rob P W; de Louw, Anton; Aldenkamp, Albert P; Ulman, Shrutin; Besseling, René M H; Hofman, Paul A M; van Kranen-Mastenbroek, Vivianne H; Hilkman, Danny M; Jansen, Jacobus F A; Backes, Walter H

    2017-03-01

    The diagnosis of epilepsy cannot be reliably made prior to a patient's second seizure in most cases. Therefore, adequate diagnostic tools are needed to differentiate subjects with a first seizure from those with a seizure preceding the onset of epilepsy. The objective was to explore spontaneous blood oxygen level-dependent (BOLD) fluctuations in subjects with a first-ever seizure and patients with new-onset epilepsy (NOE), and to find characteristic biomarkers for seizure recurrence after the first seizure. We examined 17 first-seizure subjects, 19 patients with new-onset epilepsy (NOE), and 18 healthy controls. All subjects underwent clinical investigation and received electroencephalography and resting-state functional magnetic resonance imaging (MRI). The BOLD time series were analyzed in terms of regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFFs). We found significantly stronger amplitudes (higher fALFFs) in patients with NOE relative to first-seizure subjects and healthy controls. The frequency range of 73-198 mHz (slow-3 subband) appeared most useful for discriminating patients with NOE from first-seizure subjects. The ReHo measure did not show any significant differences. The fALFF appears to be a noninvasive measure that characterizes spontaneous BOLD fluctuations and shows stronger amplitudes in the slow-3 subband of patients with NOE relative first-seizure subjects and healthy controls. A larger study population with follow-up is required to determine whether fALFF holds promise as a potential biomarker for identifying subjects at increased risk to develop epilepsy. Wiley Periodicals, Inc. © 2017 International League Against Epilepsy.

  14. Metabolic Changes Underlying Bold Signal Variations after Administration of Zolpidem

    International Nuclear Information System (INIS)

    Rodriguez-Rojas, Rafael; Machado, Calixto; Alvarez, Lazaro; Carballo, Maylen; Perez-Nellar, Jesus; Estevez, Mario; Pavon, Nancy; Chinchilla, Mauricio

    2010-12-01

    Zolpidem is a non-benzodiazepine drug belonging to the imidazopiridine class, which has selectivity for stimulating the effect of gamma aminobutyric acid [GABA] and is used for the therapy of insomnia. Nonetheless, several reports have been published over recent years about a paradoxical arousing effect of Zolpidem in patients with severe brain damage. We studied a PVS case using 1 H-MRS and BOLD signal, before and after Zolpidem administration. Significantly increased BOLD signal was localized in left frontal superior cortex, bilateral cingulated areas, left thalamus and right head of the caudate nucleus. A transient activation was observed in frontal cortex, comprising portions of anterior cingulate, medial, and orbito-frontal cortices. Additionally, significant pharmacological activation in sensory-motor cortex is observed 1 hour after Zolpidem intake. Significant linear correlations of BOLD signal changes were found with primary concentrations of NAA, Glx and Lac in the right frontal cortex. We discussed that when Zolpidem attaches to the modified GABA receptors of the neurodormant cells, dormancy is switched off, inducing brain activation. This might explain the significant correlations of BOLD signal changes and 1 H-MRS metabolites in our patient. We concluded that 1 H-MRS and BOLD signal assessment might contribute to study neurovascular coupling in PVS cases after Zolpidem administration. Although this is a report of a single case, considering our results we recommend to apply this methodology in series of PVS and MCS patients. (author)

  15. Finite Amplitude Ocean Waves

    Indian Academy of Sciences (India)

    IAS Admin

    wavelength, they are called shallow water waves. In the ... Deep and intermediate water waves are dispersive as the velocity of these depends on wavelength. This is not the ..... generation processes, the finite amplitude wave theories are very ...

  16. Real topological string amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Narain, K.S. [The Abdus Salam International Centre for Theoretical Physics (ICTP),Strada Costiera 11, Trieste, 34151 (Italy); Piazzalunga, N. [Simons Center for Geometry and Physics, State University of New York,Stony Brook, NY, 11794-3636 (United States); International School for Advanced Studies (SISSA) and INFN, Sez. di Trieste,via Bonomea 265, Trieste, 34136 (Italy); Tanzini, A. [International School for Advanced Studies (SISSA) and INFN, Sez. di Trieste,via Bonomea 265, Trieste, 34136 (Italy)

    2017-03-15

    We discuss the physical superstring correlation functions in type I theory (or equivalently type II with orientifold) that compute real topological string amplitudes. We consider the correlator corresponding to holomorphic derivative of the real topological amplitude G{sub χ}, at fixed worldsheet Euler characteristic χ. This corresponds in the low-energy effective action to N=2 Weyl multiplet, appropriately reduced to the orientifold invariant part, and raised to the power g{sup ′}=−χ+1. We show that the physical string correlator gives precisely the holomorphic derivative of topological amplitude. Finally, we apply this method to the standard closed oriented case as well, and prove a similar statement for the topological amplitude F{sub g}.

  17. Identifying and characterizing systematic temporally-lagged BOLD artifacts.

    Science.gov (United States)

    Byrge, Lisa; Kennedy, Daniel P

    2018-05-01

    Residual noise in the BOLD signal remains problematic for fMRI - particularly for techniques such as functional connectivity, where findings can be spuriously influenced by noise sources that can covary with individual differences. Many such potential noise sources - for instance, motion and respiration - can have a temporally lagged effect on the BOLD signal. Thus, here we present a tool for assessing residual lagged structure in the BOLD signal that is associated with nuisance signals, using a construction similar to a peri-event time histogram. Using this method, we find that framewise displacements - both large and very small - were followed by structured, prolonged, and global changes in the BOLD signal that depend on the magnitude of the preceding displacement and extend for tens of seconds. This residual lagged BOLD structure was consistent across datasets, and independently predicted considerable variance in the global cortical signal (as much as 30-40% in some subjects). Mean functional connectivity estimates varied similarly as a function of displacements occurring many seconds in the past, even after strict censoring. Similar patterns of residual lagged BOLD structure were apparent following respiratory fluctuations (which covaried with framewise displacements), implicating respiration as one likely mechanism underlying the displacement-linked structure observed. Global signal regression largely attenuates this artifactual structure. These findings suggest the need for caution in interpreting results of individual difference studies where noise sources might covary with the individual differences of interest, and highlight the need for further development of preprocessing techniques for mitigating such structure in a more nuanced and targeted manner. Copyright © 2018 Elsevier Inc. All rights reserved.

  18. Placental baseline conditions modulate the hyperoxic BOLD-MRI response.

    Science.gov (United States)

    Sinding, Marianne; Peters, David A; Poulsen, Sofie S; Frøkjær, Jens B; Christiansen, Ole B; Petersen, Astrid; Uldbjerg, Niels; Sørensen, Anne

    2018-01-01

    Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*). We included 49 normal pregnancies (controls) and 13 pregnancies complicated by placental dysfunction (cases), defined by a birth weight baseline BOLD)/baseline BOLD) from a dynamic single-echo gradient-recalled echo (GRE) MRI sequence and the absolute ΔT2* (hyperoxic T2*- baseline T2*) from breath-hold multi-echo GRE sequences. In the control group, the relative ΔBOLD response increased during gestation from 5% in gestational week 20 to 20% in week 40. In the case group, the relative ΔBOLD response was significantly higher (mean Z-score 4.94; 95% CI 2.41, 7.47). The absolute ΔT2*, however, did not differ between controls and cases (p = 0.37), whereas the baseline T2* was lower among cases (mean Z-score -3.13; 95% CI -3.94, -2.32). Furthermore, we demonstrated a strong negative linear correlation between the Log 10 ΔBOLD response and the baseline T2* (r = -0.88, p baseline conditions, as the absolute increase in placental oxygenation (ΔT2*) does not differ between groups. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Spatial–temporal signature of resting-state BOLD signals in classic trigeminal neuralgia

    Directory of Open Access Journals (Sweden)

    Wang Y

    2017-12-01

    Full Text Available Yanping Wang,1 Congying Xu,1 Liping Zhai,1 Xudong Lu,1 Xiaoqiang Wu,1 Yahui Yi,2 Ziyun Liu,1 Qiaobing Guan,1 Xiaoling Zhang1 1Department of Neurology, the Second Hospital of Jiaxing City, Jiaxing, Zhejiang, 2Department of Radiology, the Second Hospital of Jiaxing City, Jiaxing, Zhejiang, China Abstract: Resting-state functional magnetic resonance imaging (R-fMRI signals are spatiotemporally organized. R-fMRI studies in patients with classic trigeminal neuralgia (CTN have suggested alterations in functional connectivity. However, far less attention has been given to investigations of the local oscillations and their frequency-specific changes in these patients. The objective of this study was to address this issue in patients with CTN. R-fMRI data from 17 patients with CTN and 19 age- and gender-matched healthy controls (HCs were analyzed using amplitude of low-frequency fluctuation (ALFF. The ALFF was computed across different frequencies (slow-4: 0.027–0.073 Hz; slow-5: 0.01–0.027 Hz; and typical band: 0.01–0.08 Hz in patients with CTN compared to HCs. In the typical band, patients with CTN showed increases of ALFF in bilateral temporal, occipital, and left middle frontal regions and in the left middle cingulate gyrus, as well as decreases of ALFF in the right inferior temporal region and in regions (medial prefrontal regions of default mode network. These significant group differences were identified in different sub-bands, with greater brainstem findings in higher frequencies (slow-4 and extensive default mode network and right postparietal results in lower frequencies (slow-5. Furthermore, significant relationships were found between subjective pain ratings and both amplitudes of higher frequency (slow-4 blood oxygen level-dependent (BOLD signals in pain localization brain regions and lower frequencies (slow-5 in pain signaling/modulating brain regions in the patients, and decreased ALFF within the prefrontal regions was significantly

  20. Task effects on BOLD signal correlates of implicit syntactic processing

    Science.gov (United States)

    Caplan, David

    2010-01-01

    BOLD signal was measured in sixteen participants who made timed font change detection judgments in visually presented sentences that varied in syntactic structure and the order of animate and inanimate nouns. Behavioral data indicated that sentences were processed to the level of syntactic structure. BOLD signal increased in visual association areas bilaterally and left supramarginal gyrus in the contrast of sentences with object- and subject-extracted relative clauses without font changes in which the animacy order of the nouns biased against the syntactically determined meaning of the sentence. This result differs from the findings in a non-word detection task (Caplan et al, 2008a), in which the same contrast led to increased BOLD signal in the left inferior frontal gyrus. The difference in areas of activation indicates that the sentences were processed differently in the two tasks. These differences were further explored in an eye tracking study using the materials in the two tasks. Issues pertaining to how parsing and interpretive operations are affected by a task that is being performed, and how this might affect BOLD signal correlates of syntactic contrasts, are discussed. PMID:20671983

  1. BOLD fMRI of C-Fiber Mediated Nociceptive Processing in Mouse Brain in Response to Thermal Stimulation of the Forepaws.

    Directory of Open Access Journals (Sweden)

    Simone C Bosshard

    Full Text Available Functional magnetic resonance imaging (fMRI in rodents enables non-invasive studies of brain function in response to peripheral input or at rest. In this study we describe a thermal stimulation paradigm using infrared laser diodes to apply noxious heat to the forepaw of mice in order to study nociceptive processing. Stimulation at 45 and 46°C led to robust BOLD signal changes in various brain structures including the somatosensory cortices and the thalamus. The BOLD signal amplitude scaled with the temperature applied but not with the area irradiated by the laser beam. To demonstrate the specificity of the paradigm for assessing nociceptive signaling we administered the quaternary lidocaine derivative QX-314 to the forepaws, which due to its positive charge cannot readily cross biological membranes. However, upon activation of TRPV1 channels following the administration of capsaicin the BOLD signal was largely abolished, indicative of a selective block of the C-fiber nociceptors due to QX-314 having entered the cells via the now open TRPV1 channels. This demonstrates that the cerebral BOLD response to thermal noxious paw stimulation is specifically mediated by C-fibers.

  2. Amplitude and Ascoli analysis

    International Nuclear Information System (INIS)

    Hansen, J.D.

    1976-01-01

    This article discusses the partial wave analysis of two, three and four meson systems. The difference between the two approaches, referred to as amplitude and Ascoli analysis is discussed. Some of the results obtained with these methods are shown. (B.R.H.)

  3. Reinforcing Saccadic Amplitude Variability

    Science.gov (United States)

    Paeye, Celine; Madelain, Laurent

    2011-01-01

    Saccadic endpoint variability is often viewed as the outcome of neural noise occurring during sensorimotor processing. However, part of this variability might result from operant learning. We tested this hypothesis by reinforcing dispersions of saccadic amplitude distributions, while maintaining constant their medians. In a first experiment we…

  4. Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T.

    Science.gov (United States)

    Jorge, João; Figueiredo, Patrícia; Gruetter, Rolf; van der Zwaag, Wietske

    2018-02-20

    External stimuli and tasks often elicit negative BOLD responses in various brain regions, and growing experimental evidence supports that these phenomena are functionally meaningful. In this work, the high sensitivity available at 7T was explored to map and characterize both positive (PBRs) and negative BOLD responses (NBRs) to visual checkerboard stimulation, occurring in various brain regions within and beyond the visual cortex. Recently-proposed accelerated fMRI techniques were employed for data acquisition, and procedures for exclusion of large draining vein contributions, together with ICA-assisted denoising, were included in the analysis to improve response estimation. Besides the visual cortex, significant PBRs were found in the lateral geniculate nucleus and superior colliculus, as well as the pre-central sulcus; in these regions, response durations increased monotonically with stimulus duration, in tight covariation with the visual PBR duration. Significant NBRs were found in the visual cortex, auditory cortex, default-mode network (DMN) and superior parietal lobule; NBR durations also tended to increase with stimulus duration, but were significantly less sustained than the visual PBR, especially for the DMN and superior parietal lobule. Responses in visual and auditory cortex were further studied for checkerboard contrast dependence, and their amplitudes were found to increase monotonically with contrast, linearly correlated with the visual PBR amplitude. Overall, these findings suggest the presence of dynamic neuronal interactions across multiple brain regions, sensitive to stimulus intensity and duration, and demonstrate the richness of information obtainable when jointly mapping positive and negative BOLD responses at a whole-brain scale, with ultra-high field fMRI. © 2018 Wiley Periodicals, Inc.

  5. Light Meson Distribution Amplitudes

    CERN Document Server

    Arthur, R.; Brommel, D.; Donnellan, M.A.; Flynn, J.M.; Juttner, A.; de Lima, H.Pedroso; Rae, T.D.; Sachrajda, C.T.; Samways, B.

    2010-01-01

    We calculated the first two moments of the light-cone distribution amplitudes for the pseudoscalar mesons ($\\pi$ and $K$) and the longitudinally polarised vector mesons ($\\rho$, $K^*$ and $\\phi$) as part of the UKQCD and RBC collaborations' $N_f=2+1$ domain-wall fermion phenomenology programme. These quantities were obtained with a good precision and, in particular, the expected effects of $SU(3)$-flavour symmetry breaking were observed. Operators were renormalised non-perturbatively and extrapolations to the physical point were made, guided by leading order chiral perturbation theory. The main results presented are for two volumes, $16^3\\times 32$ and $24^3\\times 64$, with a common lattice spacing. Preliminary results for a lattice with a finer lattice spacing, $32^3\\times64$, are discussed and a first look is taken at the use of twisted boundary conditions to extract distribution amplitudes.

  6. Boldness and intermittent locomotion in the bluegill sunfish, Lepomis macrochirus

    OpenAIRE

    Alexander D.M. Wilson; Jean-Guy J. Godin

    2009-01-01

    Intermittent locomotion, characterized by moves interspersed with pauses, is a common pattern of locomotion in animals, but its ecological and evolutionary significance relative to continuous locomotion remains poorly understood. Although many studies have examined individual differences in both intermittent locomotion and boldness separately, to our knowledge, no study to date has investigated the relationship between these 2 traits. Characterizing and understanding this relationship is impo...

  7. Food intake rates of inactive fish are positively linked to boldness in three-spined sticklebacks Gasterosteus aculeatus.

    Science.gov (United States)

    Jolles, J W; Manica, A; Boogert, N J

    2016-04-01

    To investigate the link between personality and maximum food intake of inactive individuals, food-deprived three-spined sticklebacks Gasterosteus aculeatus at rest in their home compartments were provided with ad libitum prey items. Bolder individuals ate considerably more than shyer individuals, even after accounting for body size, while sociability did not have an effect. These findings support pace-of-life theory predicting that life-history strategies are linked to boldness. © 2016 The Authors. Journal of Fish Biology published by John Wiley & Sons Ltd on behalf of The Fisheries Society of the British Isles.

  8. Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data

    Science.gov (United States)

    Yücel, Meryem A.; Huppert, Theodore J.; Boas, David A.; Gagnon, Louis

    2012-01-01

    Multimodal imaging improves the accuracy of the localization and the quantification of brain activation when measuring different manifestations of the hemodynamic response associated with cerebral activity. In this study, we incorporated cerebral blood flow (CBF) changes measured with arterial spin labeling (ASL), Diffuse Optical Tomography (DOT) and blood oxygen level-dependent (BOLD) recordings to reconstruct changes in oxy- (ΔHbO2) and deoxyhemoglobin (ΔHbR). Using the Grubb relation between relative changes in CBF and cerebral blood volume (CBV), we incorporated the ASL measurement as a prior to the total hemoglobin concentration change (ΔHbT). We applied this ASL fusion model to both synthetic data and experimental multimodal recordings during a 2-sec finger-tapping task. Our results show that the new approach is very powerful in estimating ΔHbO2 and ΔHbR with high spatial and quantitative accuracy. Moreover, our approach allows the computation of baseline total hemoglobin concentration (HbT0) as well as of the BOLD calibration factor M on a single subject basis. We obtained an average HbT0 of 71 μM, an average M value of 0.18 and an average increase of 13 % in cerebral metabolic rate of oxygen (CMRO2), all of which are in agreement with values previously reported in the literature. Our method yields an independent measurement of M, which provides an alternative measurement to validate the hypercapnic calibration of the BOLD signal. PMID:22546318

  9. The BOLD cerebrovascular reactivity response to progressive hypercapnia in young and elderly

    DEFF Research Database (Denmark)

    Bhogal, Alex A.; De Vis, Jill B.; Siero, Jeroen C.W.

    2016-01-01

    to broaden our interpretation of the BOLD-CVR response. Significant age-related differences were observed. Grey matter CVR at 7 mm Hg above resting PetCO2 was lower amongst elderly (0.19 ± 0.06%ΔBOLD/mm Hg) as compared to young subjects (0.26 ± 0.07%ΔBOLD/mm Hg). White matter CVR at 7 mm Hg above baseline...

  10. Gamma rays induced bold seeded high yielding mutant in chickpea

    International Nuclear Information System (INIS)

    Wani, A.A.; Anis, M.

    2001-01-01

    In pulses especially in chickpea (Cicer arietinum L.), genetic variability has been exhausted due to natural selection and hence conventional breeding methods are not very fruitful. Mutation techniques are the best methods to enlarge the genetically conditioned variability of a species within a short time and have played a significant role in the development of many crop varieties. Investigations on the effects of ionizing radiations and chemical mutagens in induction of macro-mutations have received much attention owing to their utmost importance in plant breeding. The present study reports a bold seeded mutant in chickpea, the most dominating pulse crop on the Indian subcontinent. Fresh seeds of chickpea variety 'Pusa-212' were procured from IARI, New Delhi and treated with different doses/concentrations of gamma rays ( 60 Co source at NBRI, Lucknow) and ethyl methanesulphonate (EMS), individually as well as in combination, to raise the M1 generation. Seeds of M 1 plants were sown to raise M2 plant progenies. A bold seeded mutant was isolated from 400 Gy gamma ray treatments. The mutant was confirmed as true bred, all the mutant seeds gave rise to morphologically similar plants in M 3 , which were quite distinct from the control. The bold seeded mutant showed 'gigas' characteristics and vigorous growth. The plant remained initially straight but later on attained a trailing habit due to heavy secondary branching. The leaves, petioles, flowers, pods and seeds were almost double that of the parent variety, in size. The flowering occurred 10 days later than the parent and maturity was also delayed accordingly. Observations were recorded on various quantitative traits. Plant height and number of primary branches showed a significant improvement over the parent. It is interesting to note that the number of pods and number of seeds per pod significantly decreased. However, the hundred seed weight (31.73±0.59g) in the mutant plants was more than double in the parent

  11. Transfer function between EEG and BOLD signals of epileptic activity

    Directory of Open Access Journals (Sweden)

    Marco eLeite

    2013-01-01

    Full Text Available Simultaneous EEG-fMRI recordings have seen growing application in the evaluation of epilepsy, namely in the characterization of brain networks related to epileptic activity. In EEG-correlated fMRI studies, epileptic events are usually described as boxcar signals based on the timing information retrieved from the EEG, and subsequently convolved with a heamodynamic response function to model the associated BOLD changes. Although more flexible approaches may allow a higher degree of complexity for the haemodynamics, the issue of how to model these dynamics based on the EEG remains an open question. In this work, a new methodology for the integration of simultaneous EEG-fMRI data in epilepsy is proposed, which incorporates a transfer function from the EEG to the BOLD signal. Independent component analysis (ICA of the EEG is performed, and a number of metrics expressing different models of the EEG-BOLD transfer function are extracted from the resulting time courses. These metrics are then used to predict the fMRI data and to identify brain areas associated with the EEG epileptic activity. The methodology was tested on both ictal and interictal EEG-fMRI recordings from one patient with a hypothalamic hamartoma. When compared to the conventional analysis approach, plausible, consistent and more significant activations were obtained. Importantly, frequency-weighted EEG metrics yielded superior results than those weighted solely on the EEG power, which comes in agreement with previous literature. Reproducibility, specificity and sensitivity should be addressed in an extended group of patients in order to further validate the proposed methodology and generalize the presented proof of concept.

  12. Internal representations for face detection: an application of noise-based image classification to BOLD responses.

    Science.gov (United States)

    Nestor, Adrian; Vettel, Jean M; Tarr, Michael J

    2013-11-01

    What basic visual structures underlie human face detection and how can we extract such structures directly from the amplitude of neural responses elicited by face processing? Here, we address these issues by investigating an extension of noise-based image classification to BOLD responses recorded in high-level visual areas. First, we assess the applicability of this classification method to such data and, second, we explore its results in connection with the neural processing of faces. To this end, we construct luminance templates from white noise fields based on the response of face-selective areas in the human ventral cortex. Using behaviorally and neurally-derived classification images, our results reveal a family of simple but robust image structures subserving face representation and detection. Thus, we confirm the role played by classical face selective regions in face detection and we help clarify the representational basis of this perceptual function. From a theory standpoint, our findings support the idea of simple but highly diagnostic neurally-coded features for face detection. At the same time, from a methodological perspective, our work demonstrates the ability of noise-based image classification in conjunction with fMRI to help uncover the structure of high-level perceptual representations. Copyright © 2012 Wiley Periodicals, Inc.

  13. Greater BOLD variability in older compared with younger adults during audiovisual speech perception.

    Directory of Open Access Journals (Sweden)

    Sarah H Baum

    Full Text Available Older adults exhibit decreased performance and increased trial-to-trial variability on a range of cognitive tasks, including speech perception. We used blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI to search for neural correlates of these behavioral phenomena. We compared brain responses to simple speech stimuli (audiovisual syllables in 24 healthy older adults (53 to 70 years old and 14 younger adults (23 to 39 years old using two independent analysis strategies: region-of-interest (ROI and voxel-wise whole-brain analysis. While mean response amplitudes were moderately greater in younger adults, older adults had much greater within-subject variability. The greatly increased variability in older adults was observed for both individual voxels in the whole-brain analysis and for ROIs in the left superior temporal sulcus, the left auditory cortex, and the left visual cortex. Increased variability in older adults could not be attributed to differences in head movements between the groups. Increased neural variability may be related to the performance declines and increased behavioral variability that occur with aging.

  14. Scattering amplitudes from multivariate polynomial division

    Energy Technology Data Exchange (ETDEWEB)

    Mastrolia, Pierpaolo, E-mail: pierpaolo.mastrolia@cern.ch [Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Muenchen (Germany); Dipartimento di Fisica e Astronomia, Universita di Padova, Padova (Italy); INFN Sezione di Padova, via Marzolo 8, 35131 Padova (Italy); Mirabella, Edoardo, E-mail: mirabell@mppmu.mpg.de [Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Muenchen (Germany); Ossola, Giovanni, E-mail: GOssola@citytech.cuny.edu [New York City College of Technology, City University of New York, 300 Jay Street, Brooklyn, NY 11201 (United States); Graduate School and University Center, City University of New York, 365 Fifth Avenue, New York, NY 10016 (United States); Peraro, Tiziano, E-mail: peraro@mppmu.mpg.de [Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Muenchen (Germany)

    2012-11-15

    We show that the evaluation of scattering amplitudes can be formulated as a problem of multivariate polynomial division, with the components of the integration-momenta as indeterminates. We present a recurrence relation which, independently of the number of loops, leads to the multi-particle pole decomposition of the integrands of the scattering amplitudes. The recursive algorithm is based on the weak Nullstellensatz theorem and on the division modulo the Groebner basis associated to all possible multi-particle cuts. We apply it to dimensionally regulated one-loop amplitudes, recovering the well-known integrand-decomposition formula. Finally, we focus on the maximum-cut, defined as a system of on-shell conditions constraining the components of all the integration-momenta. By means of the Finiteness Theorem and of the Shape Lemma, we prove that the residue at the maximum-cut is parametrized by a number of coefficients equal to the number of solutions of the cut itself.

  15. Unifying relations for scattering amplitudes

    Science.gov (United States)

    Cheung, Clifford; Shen, Chia-Hsien; Wen, Congkao

    2018-02-01

    We derive new amplitudes relations revealing a hidden unity among a wideranging variety of theories in arbitrary spacetime dimensions. Our results rely on a set of Lorentz invariant differential operators which transmute physical tree-level scattering amplitudes into new ones. By transmuting the amplitudes of gravity coupled to a dilaton and two-form, we generate all the amplitudes of Einstein-Yang-Mills theory, Dirac-Born-Infield theory, special Galileon, nonlinear sigma model, and biadjoint scalar theory. Transmutation also relates amplitudes in string theory and its variants. As a corollary, celebrated aspects of gluon and graviton scattering like color-kinematics duality, the KLT relations, and the CHY construction are inherited traits of the transmuted amplitudes. Transmutation recasts the Adler zero as a trivial consequence of the Weinberg soft theorem and implies new subleading soft theorems for certain scalar theories.

  16. Crossing the implementation chasm: a proposal for bold action.

    Science.gov (United States)

    Lorenzi, Nancy M; Novak, Laurie L; Weiss, Jacob B; Gadd, Cynthia S; Unertl, Kim M

    2008-01-01

    As health care organizations dramatically increase investment in information technology (IT) and the scope of their IT projects, implementation failures become critical events. Implementation failures cause stress on clinical units, increase risk to patients, and result in massive costs that are often not recoverable. At an estimated 28% success rate, the current level of investment defies management logic. This paper asserts that there are "chasms" in IT implementations that represent risky stages in the process. Contributors to the chasms are classified into four categories: design, management, organization, and assessment. The American College of Medical Informatics symposium participants recommend bold action to better understand problems and challenges in implementation and to improve the ability of organizations to bridge these implementation chasms. The bold action includes the creation of a Team Science for Implementation strategy that allows for participation from multiple institutions to address the long standing and costly implementation issues. The outcomes of this endeavor will include a new focus on interdisciplinary research and an inter-organizational knowledge base of strategies and methods to optimize implementations and subsequent achievement of organizational objectives.

  17. Spatiotemporal alignment of in utero BOLD-MRI series.

    Science.gov (United States)

    Turk, Esra Abaci; Luo, Jie; Gagoski, Borjan; Pascau, Javier; Bibbo, Carolina; Robinson, Julian N; Grant, P Ellen; Adalsteinsson, Elfar; Golland, Polina; Malpica, Norberto

    2017-08-01

    To present a method for spatiotemporal alignment of in-utero magnetic resonance imaging (MRI) time series acquired during maternal hyperoxia for enabling improved quantitative tracking of blood oxygen level-dependent (BOLD) signal changes that characterize oxygen transport through the placenta to fetal organs. The proposed pipeline for spatiotemporal alignment of images acquired with a single-shot gradient echo echo-planar imaging includes 1) signal nonuniformity correction, 2) intravolume motion correction based on nonrigid registration, 3) correction of motion and nonrigid deformations across volumes, and 4) detection of the outlier volumes to be discarded from subsequent analysis. BOLD MRI time series collected from 10 pregnant women during 3T scans were analyzed using this pipeline. To assess pipeline performance, signal fluctuations between consecutive timepoints were examined. In addition, volume overlap and distance between manual region of interest (ROI) delineations in a subset of frames and the delineations obtained through propagation of the ROIs from the reference frame were used to quantify alignment accuracy. A previously demonstrated rigid registration approach was used for comparison. The proposed pipeline improved anatomical alignment of placenta and fetal organs over the state-of-the-art rigid motion correction methods. In particular, unexpected temporal signal fluctuations during the first normoxia period were significantly decreased (P quantitative studies of placental function by improving spatiotemporal alignment across placenta and fetal organs. 1 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:403-412. © 2017 International Society for Magnetic Resonance in Medicine.

  18. Hidden beauty in multiloop amplitudes

    International Nuclear Information System (INIS)

    Cachazo, Freddy; Spradlin, Marcus; Volovich, Anastasia

    2006-01-01

    Planar L-loop maximally helicity violating amplitudes in N = 4 supersymmetric Yang-Mills theory are believed to possess the remarkable property of satisfying iteration relations in L. We propose a simple new method for studying iteration relations for four-particle amplitudes which involves the use of certain linear differential operators and eliminates the need to fully evaluate any loop integrals. We carry out this procedure in explicit detail for the two-loop amplitude and prove that this method can be applied to any multiloop integral, allowing a conjectured iteration relation for any given amplitude to be tested up to polynomials in logarithms

  19. Two-Loop Splitting Amplitudes

    International Nuclear Information System (INIS)

    Bern, Z.

    2004-01-01

    Splitting amplitudes govern the behavior of scattering amplitudes at the momenta of external legs become collinear. In this talk we outline the calculation of two-loop splitting amplitudes via the unitarity sewing method. This method retains the simple factorization properties of light-cone gauge, but avoids the need for prescriptions such as the principal value or Mandelstam-Leibbrandt ones. The encountered loop momentum integrals are then evaluated using integration-by-parts and Lorentz invariance identities. We outline a variety of applications for these splitting amplitudes

  20. Two-loop splitting amplitudes

    International Nuclear Information System (INIS)

    Bern, Z.; Dixon, L.J.; Kosower, D.A.

    2004-01-01

    Splitting amplitudes govern the behavior of scattering amplitudes at the momenta of external legs become collinear. In this talk we outline the calculation of two-loop splitting amplitudes via the unitarity sewing method. This method retains the simple factorization properties of light-cone gauge, but avoids the need for prescriptions such as the principal value or Mandelstam-Leibbrandt ones. The encountered loop momentum integrals are then evaluated using integration-by-parts and Lorentz invariance identities. We outline a variety of applications for these splitting amplitudes

  1. Pharmacological modulation of the BOLD response: a study of acetazolamide and glyceryl trinitrate in humans

    DEFF Research Database (Denmark)

    Asghar, Mohammed Sohail; Hansen, Adam E; Pedersen, Simon

    2011-01-01

    To examine the effect of acetazolamide, known to increase cerebral blood flow (CBF) and glyceryl trinitrate (GTN), known to increase cerebral blood volume (CBV) on the blood oxygenation level-dependent (BOLD) response in humans using 3 T magnetic resonance imaging (MRI), and to evaluate how...... pharmacological agents may modulate cerebral hemodynamic and thereby possibly the BOLD signal....

  2. Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System

    DEFF Research Database (Denmark)

    Bailey, Christopher; Sanganahalli, Basavaraju G; Herman, Peter

    2012-01-01

    Neuroimaging studies of functional magnetic resonance imaging (fMRI) and electrophysiology provide the linkage between neural activity and the blood oxygenation level-dependent (BOLD) response. Here, BOLD responses to light flashes were imaged at 11.7T and compared with neural recordings from...... for general linear modeling (GLM) of BOLD responses. Light flashes induced high magnitude neural/BOLD responses reproducibly from both regions. However, neural/BOLD responses from SC and V1 were markedly different. SC signals followed the boxcar shape of the stimulation paradigm at all flash rates, whereas V1...... signals were characterized by onset/offset transients that exhibited different flash rate dependencies. We find that IRF(SC) is generally time-invariant across wider flash rate range compared with IRF(V1), whereas IRF(SC) and IRF(V1) are both space invariant. These results illustrate the importance...

  3. Brain functional BOLD perturbation modelling for forward fMRI and inverse mapping

    Science.gov (United States)

    Robinson, Jennifer; Calhoun, Vince

    2018-01-01

    Purpose To computationally separate dynamic brain functional BOLD responses from static background in a brain functional activity for forward fMRI signal analysis and inverse mapping. Methods A brain functional activity is represented in terms of magnetic source by a perturbation model: χ = χ0 +δχ, with δχ for BOLD magnetic perturbations and χ0 for background. A brain fMRI experiment produces a timeseries of complex-valued images (T2* images), whereby we extract the BOLD phase signals (denoted by δP) by a complex division. By solving an inverse problem, we reconstruct the BOLD δχ dataset from the δP dataset, and the brain χ distribution from a (unwrapped) T2* phase image. Given a 4D dataset of task BOLD fMRI, we implement brain functional mapping by temporal correlation analysis. Results Through a high-field (7T) and high-resolution (0.5mm in plane) task fMRI experiment, we demonstrated in detail the BOLD perturbation model for fMRI phase signal separation (P + δP) and reconstructing intrinsic brain magnetic source (χ and δχ). We also provided to a low-field (3T) and low-resolution (2mm) task fMRI experiment in support of single-subject fMRI study. Our experiments show that the δχ-depicted functional map reveals bidirectional BOLD χ perturbations during the task performance. Conclusions The BOLD perturbation model allows us to separate fMRI phase signal (by complex division) and to perform inverse mapping for pure BOLD δχ reconstruction for intrinsic functional χ mapping. The full brain χ reconstruction (from unwrapped fMRI phase) provides a new brain tissue image that allows to scrutinize the brain tissue idiosyncrasy for the pure BOLD δχ response through an automatic function/structure co-localization. PMID:29351339

  4. Brain functional BOLD perturbation modelling for forward fMRI and inverse mapping.

    Science.gov (United States)

    Chen, Zikuan; Robinson, Jennifer; Calhoun, Vince

    2018-01-01

    To computationally separate dynamic brain functional BOLD responses from static background in a brain functional activity for forward fMRI signal analysis and inverse mapping. A brain functional activity is represented in terms of magnetic source by a perturbation model: χ = χ0 +δχ, with δχ for BOLD magnetic perturbations and χ0 for background. A brain fMRI experiment produces a timeseries of complex-valued images (T2* images), whereby we extract the BOLD phase signals (denoted by δP) by a complex division. By solving an inverse problem, we reconstruct the BOLD δχ dataset from the δP dataset, and the brain χ distribution from a (unwrapped) T2* phase image. Given a 4D dataset of task BOLD fMRI, we implement brain functional mapping by temporal correlation analysis. Through a high-field (7T) and high-resolution (0.5mm in plane) task fMRI experiment, we demonstrated in detail the BOLD perturbation model for fMRI phase signal separation (P + δP) and reconstructing intrinsic brain magnetic source (χ and δχ). We also provided to a low-field (3T) and low-resolution (2mm) task fMRI experiment in support of single-subject fMRI study. Our experiments show that the δχ-depicted functional map reveals bidirectional BOLD χ perturbations during the task performance. The BOLD perturbation model allows us to separate fMRI phase signal (by complex division) and to perform inverse mapping for pure BOLD δχ reconstruction for intrinsic functional χ mapping. The full brain χ reconstruction (from unwrapped fMRI phase) provides a new brain tissue image that allows to scrutinize the brain tissue idiosyncrasy for the pure BOLD δχ response through an automatic function/structure co-localization.

  5. Approximate maximum parsimony and ancestral maximum likelihood.

    Science.gov (United States)

    Alon, Noga; Chor, Benny; Pardi, Fabio; Rapoport, Anat

    2010-01-01

    We explore the maximum parsimony (MP) and ancestral maximum likelihood (AML) criteria in phylogenetic tree reconstruction. Both problems are NP-hard, so we seek approximate solutions. We formulate the two problems as Steiner tree problems under appropriate distances. The gist of our approach is the succinct characterization of Steiner trees for a small number of leaves for the two distances. This enables the use of known Steiner tree approximation algorithms. The approach leads to a 16/9 approximation ratio for AML and asymptotically to a 1.55 approximation ratio for MP.

  6. Maximum permissible dose

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    This chapter presents a historic overview of the establishment of radiation guidelines by various national and international agencies. The use of maximum permissible dose and maximum permissible body burden limits to derive working standards is discussed

  7. BOLD signal and functional connectivity associated with loving kindness meditation

    Science.gov (United States)

    Garrison, Kathleen A; Scheinost, Dustin; Constable, R Todd; Brewer, Judson A

    2014-01-01

    Loving kindness is a form of meditation involving directed well-wishing, typically supported by the silent repetition of phrases such as “may all beings be happy,” to foster a feeling of selfless love. Here we used functional magnetic resonance imaging to assess the neural substrate of loving kindness meditation in experienced meditators and novices. We first assessed group differences in blood oxygen level-dependent (BOLD) signal during loving kindness meditation. We next used a relatively novel approach, the intrinsic connectivity distribution of functional connectivity, to identify regions that differ in intrinsic connectivity between groups, and then used a data-driven approach to seed-based connectivity analysis to identify which connections differ between groups. Our findings suggest group differences in brain regions involved in self-related processing and mind wandering, emotional processing, inner speech, and memory. Meditators showed overall reduced BOLD signal and intrinsic connectivity during loving kindness as compared to novices, more specifically in the posterior cingulate cortex/precuneus (PCC/PCu), a finding that is consistent with our prior work and other recent neuroimaging studies of meditation. Furthermore, meditators showed greater functional connectivity during loving kindness between the PCC/PCu and the left inferior frontal gyrus, whereas novices showed greater functional connectivity during loving kindness between the PCC/PCu and other cortical midline regions of the default mode network, the bilateral posterior insula lobe, and the bilateral parahippocampus/hippocampus. These novel findings suggest that loving kindness meditation involves a present-centered, selfless focus for meditators as compared to novices. PMID:24944863

  8. Off-shell CHY amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Lam, C.S., E-mail: Lam@physics.mcgill.ca [Department of Physics, McGill University, Montreal, Q.C., H3A 2T8 (Canada); Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, V6T 1Z1 (Canada); Yao, York-Peng, E-mail: yyao@umich.edu [Department of Physics, The University of Michigan Ann Arbor, MI 48109 (United States)

    2016-06-15

    The Cachazo–He–Yuan (CHY) formula for on-shell scattering amplitudes is extended off-shell. The off-shell amplitudes (amputated Green's functions) are Möbius invariant, and have the same momentum poles as the on-shell amplitudes. The working principles which drive the modifications to the scattering equations are mainly Möbius covariance and energy momentum conservation in off-shell kinematics. The same technique is also used to obtain off-shell massive scalars. A simple off-shell extension of the CHY gauge formula which is Möbius invariant is proposed, but its true nature awaits further study.

  9. Prospective MR image alignment between breath-holds: Application to renal BOLD MRI.

    Science.gov (United States)

    Kalis, Inge M; Pilutti, David; Krafft, Axel J; Hennig, Jürgen; Bock, Michael

    2017-04-01

    To present an image registration method for renal blood oxygen level-dependent (BOLD) measurements that enables semiautomatic assessment of parenchymal and medullary R2* changes under a functional challenge. In a series of breath-hold acquisitions, three-dimensional data were acquired initially for prospective image registration of subsequent BOLD measurements. An algorithm for kidney alignment for BOLD renal imaging (KALIBRI) was implemented to detect the positions of the left and right kidney so that the kidneys were acquired in the subsequent BOLD measurement at consistent anatomical locations. Residual in-plane distortions were corrected retrospectively so that semiautomatic dynamic R2* measurements of the renal cortex and medulla become feasible. KALIBRI was tested in six healthy volunteers during a series of BOLD experiments, which included a 600- to 1000-mL water challenge. Prospective image registration and BOLD imaging of each kidney was achieved within a total measurement time of about 17 s, enabling its execution within a single breath-hold. KALIBRI improved the registration by up to 35% as found with mutual information measures. In four volunteers, a medullary R2* decrease of up to 40% was observed after water ingestion. KALIBRI improves the quality of two-dimensional time-resolved renal BOLD MRI by aligning local renal anatomy, which allows for consistent R2* measurements over many breath-holds. Magn Reson Med 77:1573-1582, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  10. Multiscalar production amplitudes beyond threshold

    CERN Document Server

    Argyres, E N; Kleiss, R H

    1993-01-01

    We present exact tree-order amplitudes for $H^* \\to n~H$, for final states containing one or two particles with non-zero three-momentum, for various interaction potentials. We show that there are potentials leading to tree amplitudes that satisfy unitarity, not only at threshold but also in the above kinematical configurations and probably beyond. As a by-product, we also calculate $2\\to n$ tree amplitudes at threshold and show that for the unbroken $\\phi^4$ theory they vanish for $n>4~$, for the Standard Model Higgs they vanish for $n\\ge 3~$ and for a model potential, respecting tree-order unitarity, for $n$ even and $n>4~$. Finally, we calculate the imaginary part of the one-loop $1\\to n$ amplitude in both symmetric and spontaneously broken $\\phi^4$ theory.

  11. Scattering amplitudes in gauge theories

    CERN Document Server

    Henn, Johannes M

    2014-01-01

    At the fundamental level, the interactions of elementary particles are described by quantum gauge field theory. The quantitative implications of these interactions are captured by scattering amplitudes, traditionally computed using Feynman diagrams. In the past decade tremendous progress has been made in our understanding of and computational abilities with regard to scattering amplitudes in gauge theories, going beyond the traditional textbook approach. These advances build upon on-shell methods that focus on the analytic structure of the amplitudes, as well as on their recently discovered hidden symmetries. In fact, when expressed in suitable variables the amplitudes are much simpler than anticipated and hidden patterns emerge.   These modern methods are of increasing importance in phenomenological applications arising from the need for high-precision predictions for the experiments carried out at the Large Hadron Collider, as well as in foundational mathematical physics studies on the S-matrix in quantum ...

  12. Amplitude damping of vortex modes

    CSIR Research Space (South Africa)

    Dudley, Angela L

    2010-09-01

    Full Text Available An interferometer, mimicking an amplitude damping channel for vortex modes, is presented. Experimentally the action of the channel is in good agreement with that predicted theoretically. Since we can characterize the action of the channel on orbital...

  13. Motivic amplitudes and cluster coordinates

    International Nuclear Information System (INIS)

    Golden, J.K.; Goncharov, A.B.; Spradlin, M.; Vergu, C.; Volovich, A.

    2014-01-01

    In this paper we study motivic amplitudes — objects which contain all of the essential mathematical content of scattering amplitudes in planar SYM theory in a completely canonical way, free from the ambiguities inherent in any attempt to choose particular functional representatives. We find that the cluster structure on the kinematic configuration space Conf n (ℙ 3 ) underlies the structure of motivic amplitudes. Specifically, we compute explicitly the coproduct of the two-loop seven-particle MHV motivic amplitude A 7,2 M and find that like the previously known six-particle amplitude, it depends only on certain preferred coordinates known in the mathematics literature as cluster X-coordinates on Conf n (ℙ 3 ). We also find intriguing relations between motivic amplitudes and the geometry of generalized associahedrons, to which cluster coordinates have a natural combinatoric connection. For example, the obstruction to A 7,2 M being expressible in terms of classical polylogarithms is most naturally represented by certain quadrilateral faces of the appropriate associahedron. We also find and prove the first known functional equation for the trilogarithm in which all 40 arguments are cluster X-coordinates of a single algebra. In this respect it is similar to Abel’s 5-term dilogarithm identity

  14. Blood oxygenation level dependent (BOLD). Renal imaging. Concepts and applications; Blood Oxygenation Level Dependent (BOLD). Bildgebung der Nieren. Konzepte und Anwendungen

    Energy Technology Data Exchange (ETDEWEB)

    Nissen, Johanna C.; Haneder, Stefan; Schoenberg, Stefan O.; Michaely, Henrik J. [Heidelberg Univ. Medizinische Fakultaet Mannheim (Germany). Inst. fuer Klinische Radiologie und Nuklearmedizin; Mie, Moritz B.; Zoellner, Frank G. [Heidelberg Univ. Medizinische Fakultaet Mannheim (DE). Inst. fuer Computerunterstuetzte Klinische Medizin (CKM)

    2010-07-01

    Many renal diseases as well as several pharmacons cause a change in renal blood flow and/or renal oxygenation. The blood oxygenation level dependent (BOLD) imaging takes advantage of local field inhomogeneities and is based on a T2{sup *}-weighted sequence. BOLD is a non-invasive method allowing an estimation of the renal, particularly the medullary oxygenation, and an indirect measurement of blood flow without administration of contrast agents. Thus, effects of different drugs on the kidney and various renal diseases can be controlled and observed. This work will provide an overview of the studies carried out so far and identify ways how BOLD can be used in clinical studies. (orig.)

  15. Hemodynamic modelling of BOLD fMRI - A machine learning approach

    DEFF Research Database (Denmark)

    Jacobsen, Danjal Jakup

    2007-01-01

    This Ph.D. thesis concerns the application of machine learning methods to hemodynamic models for BOLD fMRI data. Several such models have been proposed by different researchers, and they have in common a basis in physiological knowledge of the hemodynamic processes involved in the generation...... of the BOLD signal. The BOLD signal is modelled as a non-linear function of underlying, hidden (non-measurable) hemodynamic state variables. The focus of this thesis work has been to develop methods for learning the parameters of such models, both in their traditional formulation, and in a state space...... formulation. In the latter, noise enters at the level of the hidden states, as well as in the BOLD measurements themselves. A framework has been developed to allow approximate posterior distributions of model parameters to be learned from real fMRI data. This is accomplished with Markov chain Monte Carlo...

  16. Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic Demand

    Directory of Open Access Journals (Sweden)

    Christopher W Tyler

    2015-12-01

    Full Text Available The coupling of the neuronal energetics to the blood-oxygen-level-dependent (BOLD response is still incompletely understood. To address this issue, we compared the fits of four plausible models of neurometabolic coupling dynamics to available data for simultaneous recordings of the local field potential (LFP and the local BOLD response recorded from monkey primary visual cortex over a wide range of stimulus durations. The four models of the metabolic demand driving the BOLD response were: direct coupling with the overall LFP; rectified coupling to the LFP; coupling with a slow adaptive component of the implied neural population response; and coupling with the non-adaptive intracellular input signal defined by the stimulus time course. Taking all stimulus durations into account, the results imply that the BOLD response is most closely coupled with metabolic demand derived from the intracellular input waveform, without significant influence from the adaptive transients and nonlinearities exhibited by the LFP waveform.

  17. The Analysis for Activations in the Brain during Hearing the Amplitude-Modulated Tone by fMRI Measurement

    Science.gov (United States)

    Fukami, Tadanori; Shimada, Takamasa; Akatsuka, Takao; Saito, Yoichi

    In audiometry, ABR (Auditory Brainstem Response) is widely used. However, it shows low accuracy in low frequency band. Meanwhile, AMFR (Amplitude-Modulation-Following Response), the response during hearing an amplitude-modulated tone, has high frequency specificity and is brought to attention. As the first step to clinical application of AMFR, we investigated the activated areas in a brain when the subjects hear SAM tone (Sinusoidally Amplitude-Modulated tone) with both ears. We measured following two signals. One is the difference of BOLD (Blood Oxygenation Level Dependent) signal between hearing SAM tone vs. silence, the other is the difference of BOLD signal between hearing SAM tone vs. unmodulated tone. As a result, in the case of SAM vs. silence, the bilaterally auditory cortex (Broadmann Area 41, 42), the biratelally BA 10, left superior frontal gyrus and right superior temporal gyrus were activated (pvs. unmodulated tone, the bilaterally superior frontal gyrus (BA 6) and precuneus (BA 7), neighboring area including the bilaterally inferior parietal lobule (BA 40), the bilaterally medial frontal gyrus and superior frontal gyrus were activated (p<0.021, uncorrected). Activations of visual perception due to eye-opened state were detected in some parts of activations. As a result, we inferred that modulated tone was recognized in the medial frontal gyrus and inferior parietal lobule was the part related to perception of amplitude-modulation.

  18. Measurement of amplitude fluctuations in a rapid response photomultiplier

    International Nuclear Information System (INIS)

    Raimbault, P.

    1961-01-01

    In order to measure amplitude fluctuations in a rapid response photomultiplier, two independent random variables are introduced which determine the shape of the anode pulse. The energy of each pulse, which depends directly on the gain and the variance, is the first variable; amplitude fluctuations, functions of the first variable, depend as well on the pulse width which in turn constitutes the second variable. The results obtained on the variations of the maximum impulse, using a steep-edged pulse broadening circuit, and those obtained on the statistical variations of the gain, are compared to show that the variance relative to the maximum amplitude of the signal is greater than that of the gain. Within the limits of these fluctuations are shown the contribution of the secondary emission coefficient of the first dynode, and that of the mean secondary emission coefficient of the multiplier. (author) [fr

  19. Nonsinglet pentagons and NMHV amplitudes

    Directory of Open Access Journals (Sweden)

    A.V. Belitsky

    2015-07-01

    Full Text Available Scattering amplitudes in maximally supersymmetric gauge theory receive a dual description in terms of the expectation value of the super Wilson loop stretched on a null polygonal contour. This makes the analysis amenable to nonperturbative techniques. Presently, we elaborate on a refined form of the operator product expansion in terms of pentagon transitions to compute twist-two contributions to NMHV amplitudes. To start with, we provide a novel derivation of scattering matrices starting from Baxter equations for flux-tube excitations propagating on magnon background. We propose bootstrap equations obeyed by pentagon form factors with nonsinglet quantum numbers with respect to the R-symmetry group and provide solutions to them to all orders in 't Hooft coupling. These are then successfully confronted against available perturbative calculations for NMHV amplitudes to four-loop order.

  20. Nonsinglet pentagons and NMHV amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Belitsky, A.V., E-mail: andrei.belitsky@asu.edu

    2015-07-15

    Scattering amplitudes in maximally supersymmetric gauge theory receive a dual description in terms of the expectation value of the super Wilson loop stretched on a null polygonal contour. This makes the analysis amenable to nonperturbative techniques. Presently, we elaborate on a refined form of the operator product expansion in terms of pentagon transitions to compute twist-two contributions to NMHV amplitudes. To start with, we provide a novel derivation of scattering matrices starting from Baxter equations for flux-tube excitations propagating on magnon background. We propose bootstrap equations obeyed by pentagon form factors with nonsinglet quantum numbers with respect to the R-symmetry group and provide solutions to them to all orders in 't Hooft coupling. These are then successfully confronted against available perturbative calculations for NMHV amplitudes to four-loop order.

  1. Cluster polylogarithms for scattering amplitudes

    International Nuclear Information System (INIS)

    Golden, John; Paulos, Miguel F; Spradlin, Marcus; Volovich, Anastasia

    2014-01-01

    Motivated by the cluster structure of two-loop scattering amplitudes in N=4 Yang-Mills theory we define cluster polylogarithm functions. We find that all such functions of weight four are made up of a single simple building block associated with the A 2 cluster algebra. Adding the requirement of locality on generalized Stasheff polytopes, we find that these A 2 building blocks arrange themselves to form a unique function associated with the A 3 cluster algebra. This A 3 function manifests all of the cluster algebraic structure of the two-loop n-particle MHV amplitudes for all n, and we use it to provide an explicit representation for the most complicated part of the n = 7 amplitude as an example. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Cluster algebras in mathematical physics’. (paper)

  2. Laser beam complex amplitude measurement by phase diversity.

    Science.gov (United States)

    Védrenne, Nicolas; Mugnier, Laurent M; Michau, Vincent; Velluet, Marie-Thérèse; Bierent, Rudolph

    2014-02-24

    The control of the optical quality of a laser beam requires a complex amplitude measurement able to deal with strong modulus variations and potentially highly perturbed wavefronts. The method proposed here consists in an extension of phase diversity to complex amplitude measurements that is effective for highly perturbed beams. Named camelot for Complex Amplitude MEasurement by a Likelihood Optimization Tool, it relies on the acquisition and processing of few images of the beam section taken along the optical path. The complex amplitude of the beam is retrieved from the images by the minimization of a Maximum a Posteriori error metric between the images and a model of the beam propagation. The analytical formalism of the method and its experimental validation are presented. The modulus of the beam is compared to a measurement of the beam profile, the phase of the beam is compared to a conventional phase diversity estimate. The precision of the experimental measurements is investigated by numerical simulations.

  3. The zerology of kaon-nucleon forward scattering amplitudes

    International Nuclear Information System (INIS)

    Dumbrajs, O.

    1981-01-01

    It has been realized for a long time that zeros of the forward kaon-nucleon scattering amplitudes are useful in correlating different low and high-energy scattering parameters and in providing a consistency test of available data. The simplest possibility of exploring zeros is to evaluate the ordinary dispersion relations in the complex energy plane. The more natural way of bringing zeros of amplitudes into play is to consider either one of the more sophisticated forms of dispersion relations: i) phase dispersion relations, ii) inverse-amplitude dispersion relations, iii) logarithmic dispersion relations, or to apply the maximum modulus theorem and a factorization theorem. The author concentrates on the use of logarithmic dispersion relations because this approach seems to be the most convenient one for future extensions to nonforward scattering data analyses based on the zeros of the amplitude. (Auth.)

  4. Non-invasive multiparametric qBOLD approach for robust mapping of the oxygen extraction fraction.

    Science.gov (United States)

    Domsch, Sebastian; Mie, Moritz B; Wenz, Frederik; Schad, Lothar R

    2014-09-01

    The quantitative blood oxygenation level-dependent (qBOLD) method has not become clinically established yet because long acquisition times are necessary to achieve an acceptable certainty of the parameter estimates. In this work, a non-invasive multiparametric (nimp) qBOLD approach based on a simple analytical model is proposed to facilitate robust oxygen extraction fraction (OEF) mapping within clinically acceptable acquisition times by using separate measurements. The protocol consisted of a gradient-echo sampled spin-echo sequence (GESSE), a T2-weighted Carr-Purcell-Meiboom-Gill (CPMG) sequence, and a T2(*)-weighted multi-slice multi-echo gradient echo (MMGE) sequence. The GESSE acquisition time was less than 5 minutes and the extra measurement time for CPMG/MMGE was below 2 minutes each. The proposed nimp-qBOLD approach was validated in healthy subjects (N = 5) and one patient. The proposed nimp-qBOLD approach facilitated more robust OEF mapping with significantly reduced inter- and intra-subject variability compared to the standard qBOLD method. Thereby, an average OEF in all subjects of 27±2% in white matter (WM) and 29±2% in gray matter (GM) using the nimp-qBOLD method was more stable compared to 41±10% (WM) and 46±10% (GM) with standard qBOLD. Moreover, the spatial variance in the image slice (i.e. standard deviation divided by mean) was on average reduced from 35% to 25%. In addition, the preliminary results of the patient are encouraging. The proposed nimp-qBOLD technique provides a promising tool for robust OEF mapping within clinically acceptable acquisition times and could therefore provide an important contribution for analyzing tumors or monitoring the success of radio and chemo therapies. Copyright © 2014. Published by Elsevier GmbH.

  5. Non-invasive multiparametric qBOLD approach for robust mapping of the oxygen extraction fraction

    Energy Technology Data Exchange (ETDEWEB)

    Domsch, Sebastian; Mie, Moritz B.; Schad, Lothar R. [Heidelberg Univ., Medical Faculty Mannheim (Germany). Computer Assisted Clinical Medicine; Wenz, Frederik [Heidelberg Univ., Medical Faculty Mannheim (Germany). Dept. of Radiation Oncology

    2014-10-01

    Introduction: The quantitative blood oxygenation level-dependent (qBOLD) method has not become clinically established yet because long acquisition times are necessary to achieve an acceptable certainty of the parameter estimates. In this work, a non-invasive multiparametric (nimp) qBOLD approach based on a simple analytical model is proposed to facilitate robust oxygen extraction fraction (OEF) mapping within clinically acceptable acquisition times by using separate measurements. Methods: The protocol consisted of a gradient-echo sampled spin-echo sequence (GESSE), a T{sub 2}-weighted Carr-Purcell-Meiboom-Gill (CPMG) sequence, and a T{sub 2}{sup *}-weighted multi-slice multi-echo gradient echo (MMGE) sequence. The GESSE acquisition time was less than 5 minutes and the extra measurement time for CPMG / MMGE was below 2 minutes each. The proposed nimp-qBOLD approach was validated in healthy subjects (N = 5) and one patient. Results: The proposed nimp-qBOLD approach facilitated more robust OEF mapping with significantly reduced inter- and intra-subject variability compared to the standard qBOLD method. Thereby, an average OEF in all subjects of 27 ± 2 % in white matter (WM) and 29 ± 2 % in gray matter (GM) using the nimp-qBOLD method was more stable compared to 41 ± 10 % (WM) and 46 ± 10 % (GM) with standard qBOLD. Moreover, the spatial variance in the image slice (i.e. standard deviation divided by mean) was on average reduced from 35 % to 25 %. In addition, the preliminary results of the patient are encouraging. Conclusion: The proposed nimp-qBOLD technique provides a promising tool for robust OEF mapping within clinically acceptable acquisition times and could therefore provide an important contribution for analyzing tumors or monitoring the success of radio and chemo therapies. (orig.)

  6. BOLD cardiovascular magnetic resonance at 3.0 tesla in myocardial ischemia.

    OpenAIRE

    Manka, R; Paetsch, I; Schnackenburg, B; Gebker, R; Fleck, E; Jahnke, C

    2010-01-01

    Abstract Background The purpose of this study was to determine the ability of Blood Oxygen Level Dependent (BOLD) cardiovascular magnetic resonance (CMR) to detect stress-inducible myocardial ischemic reactions in the presence of angiographically significant coronary artery disease (CAD). Methods Forty-six patients (34 men; age 65 ± 9 years,) with suspected or known coronary artery disease underwent CMR at 3Tesla prior to clinically indicated invasive coronary angiography. BOLD CMR was perfor...

  7. Topological amplitudes in string theory

    International Nuclear Information System (INIS)

    Antoniadis, I.; Taylor, T.R.

    1993-07-01

    We show that certain type II string amplitudes at genus g are given by the topological partition F g discussed recently by Bershadsky, Cecotti, Ooguri and Vafa. These amplitudes give rise to a term in the four-dimensional effective action of the form Σ g F g W 2g , where W is the chiral superfield of N = 2 supergravitational multiplet. The holomorphic anomaly of F g is related to non-localities of the effective action due to the propagation of massless states. This result generalizes the holomorphic anomaly of the one loop case which is known to lead to non-harmonic gravitational couplings. (author). 22 refs, 2 figs

  8. To Boldly Go: Practical Career Advice for Young Scientists

    Science.gov (United States)

    Fiske, P.

    1998-05-01

    Young scientists in nearly every field are finding the job market of the 1990's a confusing and frustrating place. Ph.D. supply is far larger than that needed to fill entry-level positions in "traditional" research careers. More new Ph.D. and Master's degree holders are considering a wider range of careers in and out of science, but feel ill-prepared and uninformed about their options. Some feel their Ph.D. training has led them to a dead-end. I present a thorough and practical overview to the process of career planning and job hunting in the 1990's, from the perspective of a young scientist. I cover specific steps that young scientists can take to broaden their horizons, strengthen their skills, and present their best face to potential employers. An important part of this is the realization that most young scientists possess a range of valuable "transferable skills" that are highly sought after by employers in and out of science. I will summarize the specifics of job hunting in the 90's, including informational interviewing, building your network, developing a compelling CV and resume, cover letters, interviewing, based on my book "To Boldly Go: A Practical Career Guide for Scientists". I will also identify other resources available for young scientists. Finally, I will highlight individual stories of Ph.D.-trained scientists who have found exciting and fulfilling careers outside the "traditional" world of academia.

  9. Gamma-ray-induced bold seeded early maturing groundnut selections

    Energy Technology Data Exchange (ETDEWEB)

    Manoharan, V; Thangavelu, S [Regional Research Station, Vriddhachalam, Tamil Nadu (India)

    1990-07-01

    Full text: ''Chico'' is an early maturing (85-90 days) erect groundnut (Arachis hypogaea L.) genotype utilised in groundnut improvement to incorporate earliness in high yielding varieties. Though it has high shelling out-turn, its yield potential is low since it has small seeds. Mutation breeding was started with the objective of improving the seed size. In a preliminary experiment, dry seeds were treated with 20, 30, 40 or 50 kR of gamma rays. The M{sub 1} generation was grown during the post rainy season of 1988-1989. The M{sub 2} generation was planted as individual plant progeny rows during the rainy season of 1989. 105 progeny rows were studied, the total number of M{sub 2} plants being 1,730. All the M{sub 2} plants were harvested 90 days after sowing. Seven mutants with bold seed size were obtained. The mutants had 100 kernel weight ranging from 22.2 to 40.4 g compared to 21.1 g of control. The study is in progress. (author)

  10. Gamma-ray-induced bold seeded early maturing groundnut selections

    International Nuclear Information System (INIS)

    Manoharan, V.; Thangavelu, S.

    1990-01-01

    Full text: ''Chico'' is an early maturing (85-90 days) erect groundnut (Arachis hypogaea L.) genotype utilised in groundnut improvement to incorporate earliness in high yielding varieties. Though it has high shelling out-turn, its yield potential is low since it has small seeds. Mutation breeding was started with the objective of improving the seed size. In a preliminary experiment, dry seeds were treated with 20, 30, 40 or 50 kR of gamma rays. The M 1 generation was grown during the post rainy season of 1988-1989. The M 2 generation was planted as individual plant progeny rows during the rainy season of 1989. 105 progeny rows were studied, the total number of M 2 plants being 1,730. All the M 2 plants were harvested 90 days after sowing. Seven mutants with bold seed size were obtained. The mutants had 100 kernel weight ranging from 22.2 to 40.4 g compared to 21.1 g of control. The study is in progress. (author)

  11. Maximum Acceleration Recording Circuit

    Science.gov (United States)

    Bozeman, Richard J., Jr.

    1995-01-01

    Coarsely digitized maximum levels recorded in blown fuses. Circuit feeds power to accelerometer and makes nonvolatile record of maximum level to which output of accelerometer rises during measurement interval. In comparison with inertia-type single-preset-trip-point mechanical maximum-acceleration-recording devices, circuit weighs less, occupies less space, and records accelerations within narrower bands of uncertainty. In comparison with prior electronic data-acquisition systems designed for same purpose, circuit simpler, less bulky, consumes less power, costs and analysis of data recorded in magnetic or electronic memory devices. Circuit used, for example, to record accelerations to which commodities subjected during transportation on trucks.

  12. "Boldness" in the domestic dog differs among breeds and breed groups.

    Science.gov (United States)

    Starling, Melissa J; Branson, Nicholas; Thomson, Peter C; McGreevy, Paul D

    2013-07-01

    "Boldness" in dogs is believed to be one end of the shy-bold axis, representing a super-trait. Several personality traits fall under the influence of this super-trait. Previous studies on boldness in dogs have found differences among breeds, but grouping breeds on the basis of behavioural similarities has been elusive. This study investigated differences in the expression of boldness among dog breeds, kennel club breed groups, and sub-groups of kennel club breed groups by way of a survey on dog personality circulated among Australian dog-training clubs and internet forums and lists. Breed had a significant effect on boldness (F=1.63, numDF=111, denDF=272, ppurpose. Retrievers were significantly bolder than flushing and pointing breeds (Reg. Coef.=2.148; S.E.=0.593; pdogs. Differences in boldness among groups and sub-groups suggest that behavioural tendencies may be influenced by historical purpose regardless of whether that purpose still factors in selective breeding. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Functional BOLD MRI: comparison of different field strengths in a motor task

    International Nuclear Information System (INIS)

    Meindl, T.; Born, C.; Britsch, S.; Reiser, M.; Schoenberg, S.

    2008-01-01

    The purpose was to evaluate the benefit of an increased field strength for functional magnetic resonance imaging in a motor task. Six right-handed volunteers were scanned at 1.5 T and 3.0 T using a motor task. Each experiment consisted of two runs with four activation blocks, each with right- and left-hand tapping. Analysis was done using BrainVoyagerQX registered . Differences between both field strengths concerning signal to noise (SNR), blood oxygen level-dependent (BOLD) signal change, functional sensitivity and BOLD contrast to noise (CNR) were tested using a paired t test. Delineation of activations and artifacts were graded by two independent readers. Results were further validated by means of a phantom study. The sensorimotor and premotor cortex, the supplementary motor area, subcortical and cerebellar structures were activated at each field strength. Additional activations of the right premotor cortex and right superior temporal gyrus were found at 3.0 T. Signal-to-noise, percentage of BOLD signal change, BOLD CNR and functional sensitivity improved at 3.0 T by a factor of up to 2.4. Functional imaging at 3.0 T results in detection of additional activated areas, increased SNR, BOLD signal change, functional sensitivity and BOLD CNR. (orig.)

  14. Maximum Quantum Entropy Method

    OpenAIRE

    Sim, Jae-Hoon; Han, Myung Joon

    2018-01-01

    Maximum entropy method for analytic continuation is extended by introducing quantum relative entropy. This new method is formulated in terms of matrix-valued functions and therefore invariant under arbitrary unitary transformation of input matrix. As a result, the continuation of off-diagonal elements becomes straightforward. Without introducing any further ambiguity, the Bayesian probabilistic interpretation is maintained just as in the conventional maximum entropy method. The applications o...

  15. Maximum power demand cost

    International Nuclear Information System (INIS)

    Biondi, L.

    1998-01-01

    The charging for a service is a supplier's remuneration for the expenses incurred in providing it. There are currently two charges for electricity: consumption and maximum demand. While no problem arises about the former, the issue is more complicated for the latter and the analysis in this article tends to show that the annual charge for maximum demand arbitrarily discriminates among consumer groups, to the disadvantage of some [it

  16. N-loop string amplitude

    International Nuclear Information System (INIS)

    Mandelstam, S.

    1986-06-01

    Work on the derivation of an explicit perturbation series for string and superstring amplitudes is reviewed. The light-cone approach is emphasized, but some work on the Polyakov approach is also mentioned, and the two methods are compared. The calculation of the measure factor is outlined in the interacting-string picture

  17. Scattering Amplitudes from Intersection Theory.

    Science.gov (United States)

    Mizera, Sebastian

    2018-04-06

    We use Picard-Lefschetz theory to prove a new formula for intersection numbers of twisted cocycles associated with a given arrangement of hyperplanes. In a special case when this arrangement produces the moduli space of punctured Riemann spheres, intersection numbers become tree-level scattering amplitudes of quantum field theories in the Cachazo-He-Yuan formulation.

  18. Positivity of spin foam amplitudes

    International Nuclear Information System (INIS)

    Baez, John C; Christensen, J Daniel

    2002-01-01

    The amplitude for a spin foam in the Barrett-Crane model of Riemannian quantum gravity is given as a product over its vertices, edges and faces, with one factor of the Riemannian 10j symbols appearing for each vertex, and simpler factors for the edges and faces. We prove that these amplitudes are always nonnegative for closed spin foams. As a corollary, all open spin foams going between a fixed pair of spin networks have real amplitudes of the same sign. This means one can use the Metropolis algorithm to compute expectation values of observables in the Riemannian Barrett-Crane model, as in statistical mechanics, even though this theory is based on a real-time (e iS ) rather than imaginary-time e -S path integral. Our proof uses the fact that when the Riemannian 10j symbols are nonzero, their sign is positive or negative depending on whether the sum of the ten spins is an integer or half-integer. For the product of 10j symbols appearing in the amplitude for a closed spin foam, these signs cancel. We conclude with some numerical evidence suggesting that the Lorentzian 10j symbols are always nonnegative, which would imply similar results for the Lorentzian Barrett-Crane model

  19. Employing Helicity Amplitudes for Resummation

    NARCIS (Netherlands)

    Moult, I.; Stewart, I.W.; Tackmann, F.J.; Waalewijn, W.J.

    2015-01-01

    Many state-of-the-art QCD calculations for multileg processes use helicity amplitudes as their fundamental ingredients. We construct a simple and easy-to-use helicity operator basis in soft-collinear effective theory (SCET), for which the hard Wilson coefficients from matching QCD onto SCET are

  20. Scattering amplitudes in gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Henn, Johannes M. [Institute for Advanced Study, Princeton, NJ (United States). School of Natural Sciences; Plefka, Jan C. [Humboldt-Universitaet, Berlin (Germany). Inst. fuer Physik

    2014-03-01

    First monographical text on this fundamental topic. Course-tested, pedagogical and self-contained exposition. Includes exercises and solutions. At the fundamental level, the interactions of elementary particles are described by quantum gauge field theory. The quantitative implications of these interactions are captured by scattering amplitudes, traditionally computed using Feynman diagrams. In the past decade tremendous progress has been made in our understanding of and computational abilities with regard to scattering amplitudes in gauge theories, going beyond the traditional textbook approach. These advances build upon on-shell methods that focus on the analytic structure of the amplitudes, as well as on their recently discovered hidden symmetries. In fact, when expressed in suitable variables the amplitudes are much simpler than anticipated and hidden patterns emerge. These modern methods are of increasing importance in phenomenological applications arising from the need for high-precision predictions for the experiments carried out at the Large Hadron Collider, as well as in foundational mathematical physics studies on the S-matrix in quantum field theory. Bridging the gap between introductory courses on quantum field theory and state-of-the-art research, these concise yet self-contained and course-tested lecture notes are well-suited for a one-semester graduate level course or as a self-study guide for anyone interested in fundamental aspects of quantum field theory and its applications. The numerous exercises and solutions included will help readers to embrace and apply the material presented in the main text.

  1. Scattering amplitudes in gauge theories

    International Nuclear Information System (INIS)

    Henn, Johannes M.; Plefka, Jan C.

    2014-01-01

    First monographical text on this fundamental topic. Course-tested, pedagogical and self-contained exposition. Includes exercises and solutions. At the fundamental level, the interactions of elementary particles are described by quantum gauge field theory. The quantitative implications of these interactions are captured by scattering amplitudes, traditionally computed using Feynman diagrams. In the past decade tremendous progress has been made in our understanding of and computational abilities with regard to scattering amplitudes in gauge theories, going beyond the traditional textbook approach. These advances build upon on-shell methods that focus on the analytic structure of the amplitudes, as well as on their recently discovered hidden symmetries. In fact, when expressed in suitable variables the amplitudes are much simpler than anticipated and hidden patterns emerge. These modern methods are of increasing importance in phenomenological applications arising from the need for high-precision predictions for the experiments carried out at the Large Hadron Collider, as well as in foundational mathematical physics studies on the S-matrix in quantum field theory. Bridging the gap between introductory courses on quantum field theory and state-of-the-art research, these concise yet self-contained and course-tested lecture notes are well-suited for a one-semester graduate level course or as a self-study guide for anyone interested in fundamental aspects of quantum field theory and its applications. The numerous exercises and solutions included will help readers to embrace and apply the material presented in the main text.

  2. Employing helicity amplitudes for resummation

    International Nuclear Information System (INIS)

    Moult, Ian; Stewart, Iain W.; Tackmann, Frank J.; Waalewijn, Wouter J.; Amsterdam Univ.

    2015-08-01

    Many state-of-the-art QCD calculations for multileg processes use helicity amplitudes as their fundamental ingredients. We construct a simple and easy-to-use helicity operator basis in soft-collinear effective theory (SCET), for which the hard Wilson coefficients from matching QCD onto SCET are directly given in terms of color-ordered helicity amplitudes. Using this basis allows one to seamlessly combine fixed-order helicity amplitudes at any order they are known with a resummation of higher-order logarithmic corrections. In particular, the virtual loop amplitudes can be employed in factorization theorems to make predictions for exclusive jet cross sections without the use of numerical subtraction schemes to handle real-virtual infrared cancellations. We also discuss matching onto SCET in renormalization schemes with helicities in 4- and d-dimensions. To demonstrate that our helicity operator basis is easy to use, we provide an explicit construction of the operator basis, as well as results for the hard matching coefficients, for pp → H+0,1,2 jets, pp → W/Z/γ+0,1,2 jets, and pp → 2,3 jets. These operator bases are completely crossing symmetric, so the results can easily be applied to processes with e + e - and e - p collisions.

  3. Discontinuity formulas for multiparticle amplitudes

    International Nuclear Information System (INIS)

    Stapp, H.P.

    1976-03-01

    It is shown how discontinuity formulas for multiparticle scattering amplitudes are derived from unitarity and analyticity. The assumed analyticity property is the normal analytic structure, which was shown to be equivalent to the space-time macrocausality condition. The discontinuity formulas to be derived are the basis of multi-particle fixed-t dispersion relations

  4. Distribution amplitudes of vector mesons

    Energy Technology Data Exchange (ETDEWEB)

    Braun, V.M. [Regensburg Univ. (Germany). Inst. fuer Theoretische Physik; Broemmel, D. [Deutsches Elektronen-Synchrotron, Hamburg (Germany); Goeckeler, M. [Regensburg Univ. (DE). Inst. fuer Theoretische Physik] (and others)

    2007-11-15

    Results are presented for the lowest moment of the distribution amplitude for the K{sup *} vector meson. Both longitudinal and transverse moments are investigated. We use two flavours of O(a) improved Wilson fermions, together with a non-perturbative renormalisation of the matrix element. (orig.)

  5. Differences in aggression, activity and boldness between native and introduced populations of an invasive crayfish

    Science.gov (United States)

    Pintor, L.M.; Sih, A.; Bauer, M.L.

    2008-01-01

    Aggressiveness, along with foraging voracity and boldness, are key behavioral mechanisms underlying the competitive displacement and invasion success of exotic species. However, do aggressiveness, voracity and boldness of the invader depend on the presence of an ecologically similar native competitor in the invaded community? We conducted four behavioral assays to compare aggression, foraging voracity, threat response and boldness to forage under predation risk of multiple populations of exotic signal crayfish Pacifastacus leniusculus across its native and invaded range with and without a native congener, the Shasta crayfish P. fortis. We predicted that signal crayfish from the invaded range and sympatric with a native congener (IRS) should be more aggressive to outcompete a close competitor than populations from the native range (NR) or invaded range and allopatric to a native congener (IRA). Furthermore, we predicted that IRS populations of signal crayfish should be more voracious, but less bold to forage under predation risk since native predators and prey likely possess appropriate behavioral responses to the invader. Contrary to our predictions, results indicated that IRA signal crayfish were more aggressive towards conspecifics and more voracious and active foragers, yet also bolder to forage under predation risk in comparison to NR and IRS populations, which did not differ in behavior. Higher aggression/voracity/ boldness was positively correlated with prey consumption rates, and hence potential impacts on prey. We suggest that the positive correlations between aggression/voracity/boldness are the result of an overall aggression syndrome. Results of stream surveys indicated that IRA streams have significantly lower prey biomass than in IRS streams, which may drive invading signal crayfish to be more aggressive/voracious/bold to acquire resources to establish a population. ?? 2008 The Authors.

  6. Volumetric BOLD fMRI simulation: from neurovascular coupling to multivoxel imaging

    International Nuclear Information System (INIS)

    Chen, Zikuan; Calhoun, Vince

    2012-01-01

    The blood oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI) modality has been numerically simulated by calculating single voxel signals. However, the observation on single voxel signals cannot provide information regarding the spatial distribution of the signals. Specifically, a single BOLD voxel signal simulation cannot answer the fundamental question: is the magnetic resonance (MR) image a replica of its underling magnetic susceptibility source? In this paper, we address this problem by proposing a multivoxel volumetric BOLD fMRI simulation model and a susceptibility expression formula for linear neurovascular coupling process, that allow us to examine the BOLD fMRI procedure from neurovascular coupling to MR image formation. Since MRI technology only senses the magnetism property, we represent a linear neurovascular-coupled BOLD state by a magnetic susceptibility expression formula, which accounts for the parameters of cortical vasculature, intravascular blood oxygenation level, and local neuroactivity. Upon the susceptibility expression of a BOLD state, we carry out volumetric BOLD fMRI simulation by calculating the fieldmap (established by susceptibility magnetization) and the complex multivoxel MR image (by intravoxel dephasing). Given the predefined susceptibility source and the calculated complex MR image, we compare the MR magnitude (phase, respectively) image with the predefined susceptibility source (the calculated fieldmap) by spatial correlation. The spatial correlation between the MR magnitude image and the magnetic susceptibility source is about 0.90 for the settings of T E = 30 ms, B 0 = 3 T, voxel size = 100 micron, vessel radius = 3 micron, and blood volume fraction = 2%. Using these parameters value, the spatial correlation between the MR phase image and the susceptibility-induced fieldmap is close to 1.00. Our simulation results show that the MR magnitude image is not an exact replica of the magnetic susceptibility

  7. Scruncher phase and amplitude control

    International Nuclear Information System (INIS)

    DeHaven, R.A.; Morris, C.L.; Johnson, R.; Davis, J.; O'Donnell, J.M.

    1992-01-01

    The analog controller for phase and amplitude control of a 402.5 MHz super conducting cavity is described in this paper. The cavity is a single cell with niobium explosively bonded to a copper cavity. It is used as an energy compressor for pions at the Clinton P. Anderson Meson Physics Facility (LAMPF). The controller maintains cavity frequency to within 4 degrees in phase of the LAMPF beam frequency. Field amplitude is maintained to within 2 percent. This control is accomplished at critical coupling (Q load of 1 x 10 9 ) with the use of only a 30 watt rf amplifier for accelerating fields of 6 MV/m. The design includes the use of piezoelectric crystals for fast resonance control. Three types of control, self excited, VCO, and a reference frequency driven, were tried on this cavity and we present a comparison of their performance. (Author) 4 figs., ref

  8. SCRUNCHER phase and amplitude control

    International Nuclear Information System (INIS)

    DeHaven, R.A.; Morris, C.L.; Johnson, R.; Davis, J.; O'Donnell, J.M.

    1992-01-01

    The analog controller for phase and amplitude control of a 402.5 MHz super conducting cavity is described in this paper. The cavity is a single cell with niobium explosively bonded to a copper cavity. It is used as an energy compressor for pions at the Clinton P. Anderson Meson Physics Facility (LAMPF). The controller maintains cavity frequency to within 4 degrees in phase of the LAMPF beam frequency. Field amplitude is maintained to within 2 percent. This control is accomplished at critical coupling (Q loaded of 1 x 10 9 ) with the use of only a 30 watt rf amplifier for accelerating fields of 6 MV/m. The design includes the use of piezoelectric crystals for fast resonance control. Three types of control, self excited VCO, and a reference frequency driven, were tried on this cavity and we present a comparison of their performance

  9. Periodic instantons and scattering amplitudes

    International Nuclear Information System (INIS)

    Khlebnikov, S.Yu.; Rubakov, V.A.; Tinyakov, P.G.

    1991-04-01

    We discuss the role of periodic euclidean solutions with two turning points and zero winding number (periodic instantons) in instanton induced processes below the sphaleron energy E sph . We find that the periodic instantons describe certain multiparticle scattering events leading to the transitions between topologically distinct vacua. Both the semiclassical amplitudes and inital and final states of these transitions are determined by the periodic instantons. Furthermore, the corresponding probabilities are maximal among all states of given energy. We show that at E ≤ E sph , the periodic instantons can be approximated by infinite chains of ordinary instantons and anti-instantons, and they naturally emerge as deformations of the zero energy instanton. In the framework of 2d abelian Higgs model and 4d electroweak theory we show, however, that there is not obvious relation between periodic instantons and two-particle scattering amplitudes. (orig.)

  10. Determination of the scattering amplitude

    International Nuclear Information System (INIS)

    Gangal, A.D.; Kupsch, J.

    1984-01-01

    The problem to determine the elastic scattering amplitude from the differential cross-section by the unitarity equation is reexamined. We prove that the solution is unique and can be determined by a convergent iteration if the parameter lambda=sin μ of Newton and Martin is bounded by lambda 2 approx.=0.86. The method is based on a fixed point theorem for holomorphic mappings in a complex Banach space. (orig.)

  11. Pulse amplitude modulated chlorophyll fluorometer

    Science.gov (United States)

    Greenbaum, Elias; Wu, Jie

    2015-12-29

    Chlorophyll fluorometry may be used for detecting toxins in a sample because of changes in micro algae. A portable lab on a chip ("LOAC") based chlorophyll fluorometer may be used for toxin detection and environmental monitoring. In particular, the system may include a microfluidic pulse amplitude modulated ("PAM") chlorophyll fluorometer. The LOAC PAM chlorophyll fluorometer may analyze microalgae and cyanobacteria that grow naturally in source drinking water.

  12. Semiclassical approach to fidelity amplitude

    International Nuclear Information System (INIS)

    García-Mata, Ignacio; Vallejos, Raúl O; Wisniacki, Diego A

    2011-01-01

    The fidelity amplitude (FA) is a quantity of paramount importance in echo-type experiments. We use semiclassical theory to study the average FA for quantum chaotic systems under external perturbation. We explain analytically two extreme cases: the random dynamics limit - attained approximately by strongly chaotic systems - and the random perturbation limit, which shows a Lyapunov decay. Numerical simulations help us to bridge the gap between both the extreme cases. (paper)

  13. Reconstruction of far-field tsunami amplitude distributions from earthquake sources

    Science.gov (United States)

    Geist, Eric L.; Parsons, Thomas E.

    2016-01-01

    The probability distribution of far-field tsunami amplitudes is explained in relation to the distribution of seismic moment at subduction zones. Tsunami amplitude distributions at tide gauge stations follow a similar functional form, well described by a tapered Pareto distribution that is parameterized by a power-law exponent and a corner amplitude. Distribution parameters are first established for eight tide gauge stations in the Pacific, using maximum likelihood estimation. A procedure is then developed to reconstruct the tsunami amplitude distribution that consists of four steps: (1) define the distribution of seismic moment at subduction zones; (2) establish a source-station scaling relation from regression analysis; (3) transform the seismic moment distribution to a tsunami amplitude distribution for each subduction zone; and (4) mix the transformed distribution for all subduction zones to an aggregate tsunami amplitude distribution specific to the tide gauge station. The tsunami amplitude distribution is adequately reconstructed for four tide gauge stations using globally constant seismic moment distribution parameters established in previous studies. In comparisons to empirical tsunami amplitude distributions from maximum likelihood estimation, the reconstructed distributions consistently exhibit higher corner amplitude values, implying that in most cases, the empirical catalogs are too short to include the largest amplitudes. Because the reconstructed distribution is based on a catalog of earthquakes that is much larger than the tsunami catalog, it is less susceptible to the effects of record-breaking events and more indicative of the actual distribution of tsunami amplitudes.

  14. Maximum likely scale estimation

    DEFF Research Database (Denmark)

    Loog, Marco; Pedersen, Kim Steenstrup; Markussen, Bo

    2005-01-01

    A maximum likelihood local scale estimation principle is presented. An actual implementation of the estimation principle uses second order moments of multiple measurements at a fixed location in the image. These measurements consist of Gaussian derivatives possibly taken at several scales and/or ...

  15. Robust Maximum Association Estimators

    NARCIS (Netherlands)

    A. Alfons (Andreas); C. Croux (Christophe); P. Filzmoser (Peter)

    2017-01-01

    textabstractThe maximum association between two multivariate variables X and Y is defined as the maximal value that a bivariate association measure between one-dimensional projections αX and αY can attain. Taking the Pearson correlation as projection index results in the first canonical correlation

  16. Role of 3T multiparametric-MRI with BOLD hypoxia imaging for diagnosis and post therapy response evaluation of postoperative recurrent cervical cancers

    International Nuclear Information System (INIS)

    Mahajan, Abhishek; Engineer, Reena; Chopra, Supriya; Mahanshetty, Umesh; Juvekar, S.L.; Shrivastava, S.K.; Desekar, Naresh; Thakur, M.H.

    2015-01-01

    •In operated cervix cancer, the accuracy of diagnosing vaginal vault/local recurrent lesions was higher at combined multiparametric MR imaging and conventional MR imaging (100%) than at conventional MR imaging (70%) or multiparametric MR imaging (96.7%) alone.•We found a significant correlation between percentage tumor regression and pre-treatment parameters: NEI (p = 0.02), the maximum slope (p = 0.04), mADC value (p = 0.001) and amount of hypoxic fraction present in the pretherapy MRI (p = 0.01).•Multiparametric and BOLD hypoxia MR Imaging are feasible and reliable in diagnosing post-operative recurrence in cervical cancer and should be applied when there is clinical suspicion of post-operative recurrence.•Quantitative image features obtained at multiparametric-MRI with BOLD hypoxia imaging has potential to be an appropriate and reliable biologic target for radiation dose painting to optimize therapy in future. In operated cervix cancer, the accuracy of diagnosing vaginal vault/local recurrent lesions was higher at combined multiparametric MR imaging and conventional MR imaging (100%) than at conventional MR imaging (70%) or multiparametric MR imaging (96.7%) alone. We found a significant correlation between percentage tumor regression and pre-treatment parameters: NEI (p = 0.02), the maximum slope (p = 0.04), mADC value (p = 0.001) and amount of hypoxic fraction present in the pretherapy MRI (p = 0.01). Multiparametric and BOLD hypoxia MR Imaging are feasible and reliable in diagnosing post-operative recurrence in cervical cancer and should be applied when there is clinical suspicion of post-operative recurrence. Quantitative image features obtained at multiparametric-MRI with BOLD hypoxia imaging has potential to be an appropriate and reliable biologic target for radiation dose painting to optimize therapy in future. To assess the diagnostic value of multiparametric-MRI (MPMRI) with hypoxia imaging as a functional marker for characterizing and detecting

  17. Time-amplitude converter; Convertisseur temps-amplitude

    Energy Technology Data Exchange (ETDEWEB)

    Banner, M [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    It is normal in high energy physics to measure the time of flight of a particle in order to determine its mass. This can be done by the method which consists in transforming the time measurement into an analysis of amplitude, which is easier; a time-amplitude converter has therefore been built for this purpose. The apparatus here described uses a double grid control tube 6 BN 6 whose resolution time, as measured with a pulse generator, is 5 x 10{sup -11} s. The analysis of the response of a particle counter, made up of a scintillator and a photomultiplier, indicates that a time of resolution of 5 x 10{sup -10} s. can be obtained. A time of this order of magnitude is obtained experimentally with the converter. This converter has been used in the study of the time of flight of particles in a secondary beam of the accelerator Saturne. It has thus been possible to measure the energy spectrum of {pi}-mesons, of protons, and of deutons emitted from a polyethylene target bombarded by 1,4 and 2 GeV protons. (author) [French] Pour determiner la masse d'une particule, il est courant, en physique des hautes energies, de mesurer le temps de vol de cette particule. Cela peut etre fait par la methode qui consiste a transformer la mesure d'un temps en une analyse d'amplitude, plus aisee; aussi a-t-on, a cet effet, cree un convertisseur temps-amplitude. L'appareillage decrit dans cet article utilise un tube a double grille de commande 6 BN 6 dont le temps de resolution mesure avec un generateur d'impulsion est de 5.10{sup -11} s. L'analyse de la reponse d'un compteur de particules, constitue par un scintillateur et un photomultiplicateur, indique qu'un temps de resolution de 5.10{sup -10} s peut etre obtenu. Un temps de cet ordre est atteint experimentalement avec le convertisseur. Ce convertisseur a servi a l'etude du temps de vol des particules dans un faisceau secondaire de l'accelerateur Saturne. On a mesure ainsi le spectre d'energie des mesons {pi}, des protons, des deutons

  18. BOLD cardiovascular magnetic resonance at 3.0 tesla in myocardial ischemia.

    Science.gov (United States)

    Manka, Robert; Paetsch, Ingo; Schnackenburg, Bernhard; Gebker, Rolf; Fleck, Eckart; Jahnke, Cosima

    2010-09-22

    The purpose of this study was to determine the ability of blood oxygen level dependent (BOLD) cardiovascular magnetic resonance (CMR) to detect stress-inducible myocardial ischemic reactions in the presence of angiographically significant coronary artery disease (CAD). Forty-six patients (34 men; age 65 ± 9 years,) with suspected or known coronary artery disease underwent CMR at 3Tesla prior to clinically indicated invasive coronary angiography. BOLD CMR was performed in 3 short axis slices of the heart at rest and during adenosine stress (140 μg/kg/min) followed by late gadolinium enhancement (LGE) imaging. In all 16 standard myocardial segments, T2* values were derived at rest and under adenosine stress. Quantitative coronary angiography served as the standard of reference and defined normal myocardial segments (i.e. all 16 segments in patients without any CAD), ischemic segments (i.e. supplied by a coronary artery with ≥50% luminal narrowing) and non-ischemic segments (i.e. supplied by a non-significantly stenosed coronary artery in patients with significant CAD). Coronary angiography demonstrated significant CAD in 23 patients. BOLD CMR at rest revealed significantly lower T2* values for ischemic segments (26.7 ± 11.6 ms) compared to normal (31.9 ± 11.9 ms; p BOLD CMR at 3Tesla proved feasible and differentiated between ischemic, non-ischemic, and normal myocardial segments in a clinical patient population. BOLD CMR during vasodilator stress identified patients with significant CAD.

  19. BOLD repetition decreases in object-responsive ventral visual areas depend on spatial attention.

    Science.gov (United States)

    Eger, E; Henson, R N A; Driver, J; Dolan, R J

    2004-08-01

    Functional imaging studies of priming-related repetition phenomena have become widely used to study neural object representation. Although blood oxygenation level-dependent (BOLD) repetition decreases can sometimes be observed without awareness of repetition, any role for spatial attention in BOLD repetition effects remains largely unknown. We used fMRI in 13 healthy subjects to test whether BOLD repetition decreases for repeated objects in ventral visual cortices depend on allocation of spatial attention to the prime. Subjects performed a size-judgment task on a probe object that had been attended or ignored in a preceding prime display of 2 lateralized objects. Reaction times showed faster responses when the probe was the same object as the attended prime, independent of the view tested (identical vs. mirror image). No behavioral effect was evident from unattended primes. BOLD repetition decreases for attended primes were found in lateral occipital and fusiform regions bilaterally, which generalized across identical and mirror-image repeats. No repetition decreases were observed for ignored primes. Our results suggest a critical role for attention in achieving visual representations of objects that lead to both BOLD signal decreases and behavioral priming on repeated presentation.

  20. Examining the time dependence of DAMA's modulation amplitude

    Science.gov (United States)

    Kelso, Chris; Savage, Christopher; Sandick, Pearl; Freese, Katherine; Gondolo, Paolo

    2018-03-01

    If dark matter is composed of weakly interacting particles, Earth's orbital motion may induce a small annual variation in the rate at which these particles interact in a terrestrial detector. The DAMA collaboration has identified at a 9.3σ confidence level such an annual modulation in their event rate over two detector iterations, DAMA/NaI and DAMA/LIBRA, each with ˜ 7 years of observations. This data is well fit by a constant modulation amplitude for the two iterations of the experiment. We statistically examine the time dependence of the modulation amplitudes, which "by eye" appear to be decreasing with time in certain energy ranges. We perform a chi-squared goodness of fit test of the average modulation amplitudes measured by the two detector iterations which rejects the hypothesis of a consistent modulation amplitude at greater than 80, 96, and 99.6% for the 2-4, 2-5 and 2-6 keVee energy ranges, respectively. We also find that among the 14 annual cycles there are three ≳ 3σ departures from the average in our estimated data in the 5-6 keVee energy range. In addition, we examined several phenomenological models for the time dependence of the modulation amplitude. Using a maximum likelihood test, we find that descriptions of the modulation amplitude as decreasing with time are preferred over a constant modulation amplitude at anywhere between 1σ and 3σ , depending on the phenomenological model for the time dependence and the signal energy range considered. A time dependent modulation amplitude is not expected for a dark matter signal, at least for dark matter halo morphologies consistent with the DAMA signal. New data from DAMA/LIBRA-phase2 will certainly aid in determining whether any apparent time dependence is a real effect or a statistical fluctuation.

  1. Dynamic Characterization and Impulse Response Modeling of Amplitude and Phase Response of Silicon Nanowires

    DEFF Research Database (Denmark)

    Cleary, Ciaran S.; Ji, Hua; Dailey, James M.

    2013-01-01

    Amplitude and phase dynamics of silicon nanowires were measured using time-resolved spectroscopy. Time shifts of the maximum phase change and minimum amplitude as a function of pump power due to saturation of the free-carrier density were observed. A phenomenological impulse response model used t...

  2. Maximum power point tracking

    International Nuclear Information System (INIS)

    Enslin, J.H.R.

    1990-01-01

    A well engineered renewable remote energy system, utilizing the principal of Maximum Power Point Tracking can be m ore cost effective, has a higher reliability and can improve the quality of life in remote areas. This paper reports that a high-efficient power electronic converter, for converting the output voltage of a solar panel, or wind generator, to the required DC battery bus voltage has been realized. The converter is controlled to track the maximum power point of the input source under varying input and output parameters. Maximum power point tracking for relative small systems is achieved by maximization of the output current in a battery charging regulator, using an optimized hill-climbing, inexpensive microprocessor based algorithm. Through practical field measurements it is shown that a minimum input source saving of 15% on 3-5 kWh/day systems can easily be achieved. A total cost saving of at least 10-15% on the capital cost of these systems are achievable for relative small rating Remote Area Power Supply systems. The advantages at larger temperature variations and larger power rated systems are much higher. Other advantages include optimal sizing and system monitor and control

  3. Amplitude modulation reflectometer for FTU

    International Nuclear Information System (INIS)

    Zerbini, M.; Buratti, P.; Centioli, C.; Amadeo, P.

    1995-06-01

    Amplitude modulation (AM) reflectometry is a modification of the classical frequency sweep technique which allows to perform unambiguous phase delay measurements. An eight-channel AM reflectometer has been realized for the measurement of density profiles on the FTU tokamak in the range. The characteristics of the instrument have been determined in extensive laboratory tests; particular attention has been devoted to the effect of interference with parasitic reflections. The reflectometer is now operating on FTU. Some examples of the first experimental data are discussed

  4. Superstring amplitudes and contact interactions

    International Nuclear Information System (INIS)

    Greensite, J.

    1987-08-01

    We show that scattering amplitudes computed from light-cone superstring field theory are divergent at tree level. The divergences can be eliminated, and supersymmetry restored, by the addition of certain counter terms to the light-cone Hamiltonian. These counter terms have the form of local contact interactions, whose existence we had previously deduced on grounds of vacuum stability, and closure of the super-Poincare algebra. The quartic contact interactions required in Type I and Type IIB superstring theories are constructed in detail. (orig.)

  5. Forward amplitude in pion deuteron

    International Nuclear Information System (INIS)

    Ferreira, E.M.; Munguia, G.A.P.; Rosa, L.P.; Thome, Z.D.

    1979-06-01

    The data on total cross section for πd scattering is analysed in terms of a single scattering calculation with Fermi motion dependence, in order to obtain a criterion to fix the value of the energy entering the two body meson nucleon amplitude. It is found that the prescription derived from the non-relativistic three body kinematics gives reasonable results. The introduction of a shift in the energy value, possibly representing nuclear binding effects, leads to a very good fitting of the data. The results are compared with those obtained in direct calculations of Faddeev equations and with the Brueckner model of fixed scatterers. (Author) [pt

  6. Re-examine tumor-induced alterations in hemodynamic responses of BOLD fMRI. Implications in presurgical brain mapping

    International Nuclear Information System (INIS)

    Wang, Liya; Ali, Shazia; Fa, Tianning; Mao, Hui; Dandan, Chen; Olson, Jeffrey

    2012-01-01

    Background: Blood oxygenation level dependent (BOLD) fMRI is used for presurgical functional mapping of brain tumor patients. Abnormal tumor blood supply may affect hemodynamic responses and BOLD fMRI signals. Purpose: To perform a multivariate and quantitative investigation of the effect of brain tumors on the hemodynamic responses and its impact on BOLD MRI signal time course, data analysis in order to better understand tumor-induced alterations in hemodynamic responses, and accurately mapping cortical regions in brain tumor patients. Material and Methods: BOLD fMRI data from 42 glioma patients who underwent presurgical mapping of the primary motor cortex (PMC) with a block designed finger tapping paradigm were analyzed, retrospectively. Cases were divided into high grade (n = 24) and low grade (n = 18) groups based on pathology. The tumor volume and distance to the activated PMCs were measured. BOLD signal time courses from selected regions of interest (ROIs) in the PMCs of tumor affected and contralateral unaffected hemispheres were obtained from each patient. Tumor-induced changes of BOLD signal intensity and time to peak (TTP) of BOLD signal time courses were analyzed statistically. Results: The BOLD signal intensity and TTP in the tumor-affected PMCs are altered when compared to that of the unaffected hemisphere. The average BOLD signal level is statistically significant lower in the affected PMCs. The average TTP in the affected PMCs is shorter in the high grade group, but longer in the low grade tumor group compared to the contralateral unaffected hemisphere. Degrees of alterations in BOLD signal time courses are related to both the distance to activated foci and tumor volume with the stronger effect in tumor distance to activated PMC. Conclusion: Alterations in BOLD signal time courses are strongly related to the tumor grade, the tumor volume, and the distance to the activated foci. Such alterations may impair accurate mapping of tumor-affected functional

  7. Evolution of boldness and life-history in response to selective harvesting

    DEFF Research Database (Denmark)

    Andersen, Ken Haste; Marty, Lise; Arlinghaus, Robert

    2018-01-01

    Whether intensive harvesting alters the behavioral repertoire of exploited fishes is currently unknown, but plausible. We extend a fish life-history model to account for boldness as a personality trait that affects foraging intensity, which affects energy intake and risk from predation and fishing...... gear. We systematically investigate life-history and behavioral trait evolution along the boldness–timidity axis in response to the full range of common selectivity and exploitation patterns in fisheries. In agreement with previous studies, we find that any type of harvesting selects for fast life...... histories and that merely elevated, yet unselective, fishing mortality favors boldness. We also find that timid-selective fishing (which can be expected in species targeted by active gear types) selects for increased boldness. By contrast, increased timidity is predicted when fishing targets bolder...

  8. PARTICLE FILTERING WITH SEQUENTIAL PARAMETER LEARNING FOR NONLINEAR BOLD fMRI SIGNALS.

    Science.gov (United States)

    Xia, Jing; Wang, Michelle Yongmei

    Analyzing the blood oxygenation level dependent (BOLD) effect in the functional magnetic resonance imaging (fMRI) is typically based on recent ground-breaking time series analysis techniques. This work represents a significant improvement over existing approaches to system identification using nonlinear hemodynamic models. It is important for three reasons. First, instead of using linearized approximations of the dynamics, we present a nonlinear filtering based on the sequential Monte Carlo method to capture the inherent nonlinearities in the physiological system. Second, we simultaneously estimate the hidden physiological states and the system parameters through particle filtering with sequential parameter learning to fully take advantage of the dynamic information of the BOLD signals. Third, during the unknown static parameter learning, we employ the low-dimensional sufficient statistics for efficiency and avoiding potential degeneration of the parameters. The performance of the proposed method is validated using both the simulated data and real BOLD fMRI data.

  9. Time courses of MRI BOLD signals in prolonged visual stimulation. Comparison between colors and orders

    International Nuclear Information System (INIS)

    Kashikura, Kenichi; Fujita, Hideaki; Kershaw, J.B.; Matsuura, Tetsuya; Seki, Chie; Kashikura, Akemi; Ardekani, B.A.; Kanno, Iwao

    1998-01-01

    We investigated: the BOLD signal response during 270 second photic stimulation using an EPI pulse sequence; the BOLD signal response for two different color checkerboards; and the BOLD signal response during six consecutive stimulation series. Ten healthy human subjects (age 25±5.5 years) were studied with a 1.5 T MRI system (Siemens Vision, Erlangen, Germany). Black and white (BW) and red and white (RW) checkerboards alternating at 8 Hz were applied in turns for a total series of six. Stimulation timing was: 30 sec. off, 15 sec. on, 15 sec. off, 270 sec. on, 15 sec. off, 15 sec. on, 15 sec. off. Acquired data were analyzed according to color and/or order: color (without considering the order); color and order (1st BW vs. 1st RW, 2nd BW vs. 2nd RW, 3rd BW vs. 3rd RW); and order (without considering the color). A t-test (p<0.001) was used for obtaining the activated areas, and simple regression and two-way repeated-measures ANOVA were used for testing the statistical significance of the BOLD response. Results were: the BOLD signal responses during sustained photic stimulation maintained a constant level for the full duration and all series, suggesting stable levels of oxygen extraction and metabolism during cortical activation; the BOLD signal responses in two colors showed no significant difference in time response, suggesting that the neuronal populations perceiving black and red give a similar time response; and the effect of habituation or fatigue as observed by a signal decrease was not obtained, although the S.D. for each subject greatly increased with time and might be an indicator for evaluation fatigue or attention. (author)

  10. Simultaneous Imaging of CBF Change and BOLD with Saturation-Recovery-T1 Method.

    Directory of Open Access Journals (Sweden)

    Xiao Wang

    Full Text Available A neuroimaging technique based on the saturation-recovery (SR-T1 MRI method was applied for simultaneously imaging blood oxygenation level dependence (BOLD contrast and cerebral blood flow change (ΔCBF, which is determined by CBF-sensitive T1 relaxation rate change (ΔR1CBF. This technique was validated by quantitatively examining the relationships among ΔR1CBF, ΔCBF, BOLD and relative CBF change (rCBF, which was simultaneously measured by laser Doppler flowmetry under global ischemia and hypercapnia conditions, respectively, in the rat brain. It was found that during ischemia, BOLD decreased 23.1±2.8% in the cortical area; ΔR1CBF decreased 0.020±0.004s-1 corresponding to a ΔCBF decrease of 1.07±0.24 ml/g/min and 89.5±1.8% CBF reduction (n=5, resulting in a baseline CBF value (=1.18 ml/g/min consistent with the literature reports. The CBF change quantification based on temperature corrected ΔR1CBF had a better accuracy than apparent R1 change (ΔR1app; nevertheless, ΔR1app without temperature correction still provides a good approximation for quantifying CBF change since perfusion dominates the evolution of the longitudinal relaxation rate (R1app. In contrast to the excellent consistency between ΔCBF and rCBF measured during and after ischemia, the BOLD change during the post-ischemia period was temporally disassociated with ΔCBF, indicating distinct CBF and BOLD responses. Similar results were also observed for the hypercapnia study. The overall results demonstrate that the SR-T1 MRI method is effective for noninvasive and quantitative imaging of both ΔCBF and BOLD associated with physiological and/or pathological changes.

  11. Developmental changes of BOLD signal correlations with global human EEG power and synchronization during working memory.

    Directory of Open Access Journals (Sweden)

    Lars Michels

    Full Text Available In humans, theta band (5-7 Hz power typically increases when performing cognitively demanding working memory (WM tasks, and simultaneous EEG-fMRI recordings have revealed an inverse relationship between theta power and the BOLD (blood oxygen level dependent signal in the default mode network during WM. However, synchronization also plays a fundamental role in cognitive processing, and the level of theta and higher frequency band synchronization is modulated during WM. Yet, little is known about the link between BOLD, EEG power, and EEG synchronization during WM, and how these measures develop with human brain maturation or relate to behavioral changes. We examined EEG-BOLD signal correlations from 18 young adults and 15 school-aged children for age-dependent effects during a load-modulated Sternberg WM task. Frontal load (in-dependent EEG theta power was significantly enhanced in children compared to adults, while adults showed stronger fMRI load effects. Children demonstrated a stronger negative correlation between global theta power and the BOLD signal in the default mode network relative to adults. Therefore, we conclude that theta power mediates the suppression of a task-irrelevant network. We further conclude that children suppress this network even more than adults, probably from an increased level of task-preparedness to compensate for not fully mature cognitive functions, reflected in lower response accuracy and increased reaction time. In contrast to power, correlations between instantaneous theta global field synchronization and the BOLD signal were exclusively positive in both age groups but only significant in adults in the frontal-parietal and posterior cingulate cortices. Furthermore, theta synchronization was weaker in children and was--in contrast to EEG power--positively correlated with response accuracy in both age groups. In summary we conclude that theta EEG-BOLD signal correlations differ between spectral power and

  12. Research progress of BOLD-fMRI in minimal hepatic encephalopathy

    International Nuclear Information System (INIS)

    Zhou Zhiming; Zhao Jiannong

    2013-01-01

    The minimal hepatic encephalopathy is the early stage of hepatic encephalopathy. It has few apparent clinical symptoms and specific manifestations, and is difficult to diagnose. In the recent years, BOLD-fMRI has been used to study hepatic encephalopathy gradually. Through detection of the brain neuron activities in different states, it can not only locate the abnormal activity of brain functional areas, but also can find the changes of brain functional connectivity. BOLD- fMRI combining with other MR technologies can explore the pathology and pathogenesis of minimal hepatic encephalopathy from micro to macro and from structure to function. (authors)

  13. Maximum entropy methods

    International Nuclear Information System (INIS)

    Ponman, T.J.

    1984-01-01

    For some years now two different expressions have been in use for maximum entropy image restoration and there has been some controversy over which one is appropriate for a given problem. Here two further entropies are presented and it is argued that there is no single correct algorithm. The properties of the four different methods are compared using simple 1D simulations with a view to showing how they can be used together to gain as much information as possible about the original object. (orig.)

  14. Blood Flow and Brain Function: Investigations of neurovascular coupling using BOLD fMRI at 7 tesla

    NARCIS (Netherlands)

    Siero, J.C.W.

    2013-01-01

    The advent of ultra high field (7 tesla) MRI systems has opened the possibility to probe biological processes of the human body in great detail. Especially for studying brain function using BOLD fMRI there is a large benefit from the increased magnetic field strength. BOLD fMRI is the working horse

  15. Multi-Channel Maximum Likelihood Pitch Estimation

    DEFF Research Database (Denmark)

    Christensen, Mads Græsbøll

    2012-01-01

    In this paper, a method for multi-channel pitch estimation is proposed. The method is a maximum likelihood estimator and is based on a parametric model where the signals in the various channels share the same fundamental frequency but can have different amplitudes, phases, and noise characteristics....... This essentially means that the model allows for different conditions in the various channels, like different signal-to-noise ratios, microphone characteristics and reverberation. Moreover, the method does not assume that a certain array structure is used but rather relies on a more general model and is hence...

  16. The last glacial maximum

    Science.gov (United States)

    Clark, P.U.; Dyke, A.S.; Shakun, J.D.; Carlson, A.E.; Clark, J.; Wohlfarth, B.; Mitrovica, J.X.; Hostetler, S.W.; McCabe, A.M.

    2009-01-01

    We used 5704 14C, 10Be, and 3He ages that span the interval from 10,000 to 50,000 years ago (10 to 50 ka) to constrain the timing of the Last Glacial Maximum (LGM) in terms of global ice-sheet and mountain-glacier extent. Growth of the ice sheets to their maximum positions occurred between 33.0 and 26.5 ka in response to climate forcing from decreases in northern summer insolation, tropical Pacific sea surface temperatures, and atmospheric CO2. Nearly all ice sheets were at their LGM positions from 26.5 ka to 19 to 20 ka, corresponding to minima in these forcings. The onset of Northern Hemisphere deglaciation 19 to 20 ka was induced by an increase in northern summer insolation, providing the source for an abrupt rise in sea level. The onset of deglaciation of the West Antarctic Ice Sheet occurred between 14 and 15 ka, consistent with evidence that this was the primary source for an abrupt rise in sea level ???14.5 ka.

  17. Covariant amplitudes in Polyakov string theory

    International Nuclear Information System (INIS)

    Aoyama, H.; Dhar, A.; Namazie, M.A.

    1986-01-01

    A manifestly Lorentz-covariant and reparametrization-invariant procedure for computing string amplitudes using Polyakov's formulation is described. Both bosonic and superstring theories are dealt with. The computation of string amplitudes is greatly facilitated by this formalism. (orig.)

  18. Leading Wave Amplitude of a Tsunami

    Science.gov (United States)

    Kanoglu, U.

    2015-12-01

    Okal and Synolakis (EGU General Assembly 2015, Geophysical Research Abstracts-Vol. 17-7622) recently discussed that why the maximum amplitude of a tsunami might not occur for the first wave. Okal and Synolakis list observations from 2011 Japan tsunami, which reached to Papeete, Tahiti with a fourth wave being largest and 72 min later after the first wave; 1960 Chilean tsunami reached Hilo, Hawaii with a maximum wave arriving 1 hour later with a height of 5m, first wave being only 1.2m. Largest later waves is a problem not only for local authorities both in terms of warning to the public and rescue efforts but also mislead the public thinking that it is safe to return shoreline or evacuated site after arrival of the first wave. Okal and Synolakis considered Hammack's (1972, Ph.D. Dissertation, Calif. Inst. Tech., 261 pp., Pasadena) linear dispersive analytical solution with a tsunami generation through an uplifting of a circular plug on the ocean floor. They performed parametric study for the radius of the plug and the depth of the ocean since these are the independent scaling lengths in the problem. They identified transition distance, as the second wave being larger, regarding the parameters of the problem. Here, we extend their analysis to an initial wave field with a finite crest length and, in addition, to a most common tsunami initial wave form of N-wave as presented by Tadepalli and Synolakis (1994, Proc. R. Soc. A: Math. Phys. Eng. Sci., 445, 99-112). We compare our results with non-dispersive linear shallow water wave results as presented by Kanoglu et al. (2013, Proc. R. Soc. A: Math. Phys. Eng. Sci., 469, 20130015), investigating focusing feature. We discuss the results both in terms of leading wave amplitude and tsunami focusing. Acknowledgment: The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 603839 (Project ASTARTE - Assessment, Strategy and Risk

  19. Negative BOLD signal changes in ipsilateral primary somatosensory cortex are associated with perfusion decreases and behavioral evidence for functional inhibition

    DEFF Research Database (Denmark)

    Schäfer, Katharina; Blankenburg, Felix; Kupers, Ron

    2012-01-01

    that the negative BOLD signal is associated with functional inhibition. Electrical stimulation of the median nerve at 7Hz evoked robust negative BOLD signals in the primary somatosensory cortex (SI) ipsilateral to stimulation, and positive BOLD signals in contralateral SI. The negative BOLD signal in ipsilateral SI......) at the ipsilateral finger during concomitant stimulation of the contralateral median nerve increased significantly, suggesting augmented functional inhibition. Since the CPT in the ipsilateral hallux did not significantly change in response to median nerve stimulation, it is more likely that the CPT......-increase for the finger is due to functional inhibition (Kastrup et al., 2008) than to changes in selective attention. In conclusion, our data provide evidence that stimulus-induced reductions in relative rCBF may underlie the negative BOLD signal, which in turn may reflect increments in functional inhibition....

  20. Grassmannian geometry of scattering amplitudes

    CERN Document Server

    Arkani-Hamed, Nima; Cachazo, Freddy; Goncharov, Alexander; Postnikov, Alexander; Trnka, Jaroslav

    2016-01-01

    Outlining a revolutionary reformulation of the foundations of perturbative quantum field theory, this book is a self-contained and authoritative analysis of the application of this new formulation to the case of planar, maximally supersymmetric Yang–Mills theory. The book begins by deriving connections between scattering amplitudes and Grassmannian geometry from first principles before introducing novel physical and mathematical ideas in a systematic manner accessible to both physicists and mathematicians. The principle players in this process are on-shell functions which are closely related to certain sub-strata of Grassmannian manifolds called positroids - in terms of which the classification of on-shell functions and their relations becomes combinatorially manifest. This is an essential introduction to the geometry and combinatorics of the positroid stratification of the Grassmannian and an ideal text for advanced students and researchers working in the areas of field theory, high energy physics, and the...

  1. Determination of backward pion nucleon scattering amplitudes

    International Nuclear Information System (INIS)

    Pietarinen, E.

    1978-04-01

    Backward C(sup(+-))πN amplitudes are determined from πN→Nπ and NantiN→2π differential cross sections in such a way that they are consistent with the analyticity properties and information of the unphysical ππ→NantiN amplitudes. Combining the result with forward C(sup(+-)) amplitudes positive and negative parity resonances are extracted. An error analysis of the amplitudes is performed. (author)

  2. Maximum Entropy Fundamentals

    Directory of Open Access Journals (Sweden)

    F. Topsøe

    2001-09-01

    Full Text Available Abstract: In its modern formulation, the Maximum Entropy Principle was promoted by E.T. Jaynes, starting in the mid-fifties. The principle dictates that one should look for a distribution, consistent with available information, which maximizes the entropy. However, this principle focuses only on distributions and it appears advantageous to bring information theoretical thinking more prominently into play by also focusing on the "observer" and on coding. This view was brought forward by the second named author in the late seventies and is the view we will follow-up on here. It leads to the consideration of a certain game, the Code Length Game and, via standard game theoretical thinking, to a principle of Game Theoretical Equilibrium. This principle is more basic than the Maximum Entropy Principle in the sense that the search for one type of optimal strategies in the Code Length Game translates directly into the search for distributions with maximum entropy. In the present paper we offer a self-contained and comprehensive treatment of fundamentals of both principles mentioned, based on a study of the Code Length Game. Though new concepts and results are presented, the reading should be instructional and accessible to a rather wide audience, at least if certain mathematical details are left aside at a rst reading. The most frequently studied instance of entropy maximization pertains to the Mean Energy Model which involves a moment constraint related to a given function, here taken to represent "energy". This type of application is very well known from the literature with hundreds of applications pertaining to several different elds and will also here serve as important illustration of the theory. But our approach reaches further, especially regarding the study of continuity properties of the entropy function, and this leads to new results which allow a discussion of models with so-called entropy loss. These results have tempted us to speculate over

  3. Decreasing the amplitude deviation of Guassian filter in surface roughness measurements

    Science.gov (United States)

    Liu, Bo; Wang, Yu

    2008-12-01

    A new approach for decreasing the amplitude characteristic deviation of Guassian filter in surface roughness measurements is presented in this paper. According to Central Limit Theorem, many different Guassian approximation filters could be constructed. By using first-order Butterworth filter and moving average filter to approximate Guassian filter, their directions of amplitude deviation are opposite, and their locations of extreme value are close. So the linear combination of them could reduce the amplitude deviation greatly. The maximum amplitude deviation is only about 0.11% through paralleling them. The algorithm of this new method is simple and its efficiency is high.

  4. Probable maximum flood control

    International Nuclear Information System (INIS)

    DeGabriele, C.E.; Wu, C.L.

    1991-11-01

    This study proposes preliminary design concepts to protect the waste-handling facilities and all shaft and ramp entries to the underground from the probable maximum flood (PMF) in the current design configuration for the proposed Nevada Nuclear Waste Storage Investigation (NNWSI) repository protection provisions were furnished by the United States Bureau of Reclamation (USSR) or developed from USSR data. Proposed flood protection provisions include site grading, drainage channels, and diversion dikes. Figures are provided to show these proposed flood protection provisions at each area investigated. These areas are the central surface facilities (including the waste-handling building and waste treatment building), tuff ramp portal, waste ramp portal, men-and-materials shaft, emplacement exhaust shaft, and exploratory shafts facility

  5. Introduction to maximum entropy

    International Nuclear Information System (INIS)

    Sivia, D.S.

    1988-01-01

    The maximum entropy (MaxEnt) principle has been successfully used in image reconstruction in a wide variety of fields. We review the need for such methods in data analysis and show, by use of a very simple example, why MaxEnt is to be preferred over other regularizing functions. This leads to a more general interpretation of the MaxEnt method, and its use is illustrated with several different examples. Practical difficulties with non-linear problems still remain, this being highlighted by the notorious phase problem in crystallography. We conclude with an example from neutron scattering, using data from a filter difference spectrometer to contrast MaxEnt with a conventional deconvolution. 12 refs., 8 figs., 1 tab

  6. Solar maximum observatory

    International Nuclear Information System (INIS)

    Rust, D.M.

    1984-01-01

    The successful retrieval and repair of the Solar Maximum Mission (SMM) satellite by Shuttle astronauts in April 1984 permitted continuance of solar flare observations that began in 1980. The SMM carries a soft X ray polychromator, gamma ray, UV and hard X ray imaging spectrometers, a coronagraph/polarimeter and particle counters. The data gathered thus far indicated that electrical potentials of 25 MeV develop in flares within 2 sec of onset. X ray data show that flares are composed of compressed magnetic loops that have come too close together. Other data have been taken on mass ejection, impacts of electron beams and conduction fronts with the chromosphere and changes in the solar radiant flux due to sunspots. 13 references

  7. Introduction to maximum entropy

    International Nuclear Information System (INIS)

    Sivia, D.S.

    1989-01-01

    The maximum entropy (MaxEnt) principle has been successfully used in image reconstruction in a wide variety of fields. The author reviews the need for such methods in data analysis and shows, by use of a very simple example, why MaxEnt is to be preferred over other regularizing functions. This leads to a more general interpretation of the MaxEnt method, and its use is illustrated with several different examples. Practical difficulties with non-linear problems still remain, this being highlighted by the notorious phase problem in crystallography. He concludes with an example from neutron scattering, using data from a filter difference spectrometer to contrast MaxEnt with a conventional deconvolution. 12 refs., 8 figs., 1 tab

  8. Functional Maximum Autocorrelation Factors

    DEFF Research Database (Denmark)

    Larsen, Rasmus; Nielsen, Allan Aasbjerg

    2005-01-01

    MAF outperforms the functional PCA in concentrating the interesting' spectra/shape variation in one end of the eigenvalue spectrum and allows for easier interpretation of effects. Conclusions. Functional MAF analysis is a useful methods for extracting low dimensional models of temporally or spatially......Purpose. We aim at data where samples of an underlying function are observed in a spatial or temporal layout. Examples of underlying functions are reflectance spectra and biological shapes. We apply functional models based on smoothing splines and generalize the functional PCA in......\\verb+~+\\$\\backslash\\$cite{ramsay97} to functional maximum autocorrelation factors (MAF)\\verb+~+\\$\\backslash\\$cite{switzer85,larsen2001d}. We apply the method to biological shapes as well as reflectance spectra. {\\$\\backslash\\$bf Methods}. MAF seeks linear combination of the original variables that maximize autocorrelation between...

  9. Regularized maximum correntropy machine

    KAUST Repository

    Wang, Jim Jing-Yan; Wang, Yunji; Jing, Bing-Yi; Gao, Xin

    2015-01-01

    In this paper we investigate the usage of regularized correntropy framework for learning of classifiers from noisy labels. The class label predictors learned by minimizing transitional loss functions are sensitive to the noisy and outlying labels of training samples, because the transitional loss functions are equally applied to all the samples. To solve this problem, we propose to learn the class label predictors by maximizing the correntropy between the predicted labels and the true labels of the training samples, under the regularized Maximum Correntropy Criteria (MCC) framework. Moreover, we regularize the predictor parameter to control the complexity of the predictor. The learning problem is formulated by an objective function considering the parameter regularization and MCC simultaneously. By optimizing the objective function alternately, we develop a novel predictor learning algorithm. The experiments on two challenging pattern classification tasks show that it significantly outperforms the machines with transitional loss functions.

  10. Regularized maximum correntropy machine

    KAUST Repository

    Wang, Jim Jing-Yan

    2015-02-12

    In this paper we investigate the usage of regularized correntropy framework for learning of classifiers from noisy labels. The class label predictors learned by minimizing transitional loss functions are sensitive to the noisy and outlying labels of training samples, because the transitional loss functions are equally applied to all the samples. To solve this problem, we propose to learn the class label predictors by maximizing the correntropy between the predicted labels and the true labels of the training samples, under the regularized Maximum Correntropy Criteria (MCC) framework. Moreover, we regularize the predictor parameter to control the complexity of the predictor. The learning problem is formulated by an objective function considering the parameter regularization and MCC simultaneously. By optimizing the objective function alternately, we develop a novel predictor learning algorithm. The experiments on two challenging pattern classification tasks show that it significantly outperforms the machines with transitional loss functions.

  11. Using pulse oximetry to account for high and low frequency physiological artifacts in the BOLD signal.

    Science.gov (United States)

    Verstynen, Timothy D; Deshpande, Vibhas

    2011-04-15

    The BOLD signal not only reflects changes in local neural activity, but also exhibits variability from physiological processes like cardiac rhythms and breathing. We investigated how both of these physiological sources are reflected in the pulse oximetry (PO) signal, a direct measure of blood oxygenation, and how this information can be used to account for different types of noise in the BOLD response. Measures of heart rate, respiration and PO were simultaneously recorded while neurologically healthy participants performed an eye-movement task in a 3T MRI. PO exhibited power in frequencies that matched those found in the independently recorded cardiac and respiration signals. Using the phasic and aphasic properties of these signals as nuisance regressors, we found that the different frequency components of the PO signal could be used to identify different types of physiological artifacts in the BOLD response. A comparison of different physiological noise models found that a simple, down-sampled version of the PO signal improves the estimation of task-relevant statistics nearly as well as more established noise models that may run the risk of over-parameterization. These findings suggest that the PO signal captures multiple sources of physiological noise in the BOLD response and provides a simple and efficient way of modeling these noise sources in subsequent analysis. Copyright © 2011 Elsevier Inc. All rights reserved.

  12. Wavelet entropy of BOLD time series : an application to Rolandic epilepsy

    NARCIS (Netherlands)

    Gupta, Lalit; Jansen, Jacobus F.A.; Hofman, Paul A.M.; Besseling, René M.H.; de Louw, Anton J.A.; Aldenkamp, Albert P.; Backes, Walter H.

    2017-01-01

    Purpose: To assess the wavelet entropy for the characterization of intrinsic aberrant temporal irregularities in the time series of resting-state blood-oxygen-level-dependent (BOLD) signal fluctuations. Further, to evaluate the temporal irregularities (disorder/order) on a voxel-by-voxel basis in

  13. Evidence accumulation detected in BOLD signal using slow perceptual decision making

    NARCIS (Netherlands)

    Krueger, Paul M.; van Vugt, Marieke K.; Simen, Patrick; Nystrom, Leigh; Holmes, Philip; Cohen, Jonathan D.

    2017-01-01

    BACKGROUND: We assessed whether evidence accumulation could be observed in the BOLD signal during perceptual decision making. This presents a challenge since the hemodynamic response is slow, while perceptual decisions are typically fast. NEW METHOD: Guided by theoretical predictions of the drift

  14. Driving innovation through big open linked data (BOLD) : Exploring antecedents using interpretive structural modelling

    NARCIS (Netherlands)

    Dwivedi, Yogesh K.; Janssen, M.F.W.H.A.; Slade, Emma L.; Rana, Nripendra P.; Weerakkody, Vishanth; Millard, Jeremy; Hidders, Jan; Snijders, D.

    2016-01-01

    Innovation is vital to find new solutions to problems, increase quality, and improve profitability. Big open linked data (BOLD) is a fledgling and rapidly evolving field that creates new opportunities for innovation. However, none of the existing literature has yet considered the

  15. Development of visual cortical function in infant macaques: A BOLD fMRI study.

    Directory of Open Access Journals (Sweden)

    Tom J Van Grootel

    Full Text Available Functional brain development is not well understood. In the visual system, neurophysiological studies in nonhuman primates show quite mature neuronal properties near birth although visual function is itself quite immature and continues to develop over many months or years after birth. Our goal was to assess the relative development of two main visual processing streams, dorsal and ventral, using BOLD fMRI in an attempt to understand the global mechanisms that support the maturation of visual behavior. Seven infant macaque monkeys (Macaca mulatta were repeatedly scanned, while anesthetized, over an age range of 102 to 1431 days. Large rotating checkerboard stimuli induced BOLD activation in visual cortices at early ages. Additionally we used static and dynamic Glass pattern stimuli to probe BOLD responses in primary visual cortex and two extrastriate areas: V4 and MT-V5. The resulting activations were analyzed with standard GLM and multivoxel pattern analysis (MVPA approaches. We analyzed three contrasts: Glass pattern present/absent, static/dynamic Glass pattern presentation, and structured/random Glass pattern form. For both GLM and MVPA approaches, robust coherent BOLD activation appeared relatively late in comparison to the maturation of known neuronal properties and the development of behavioral sensitivity to Glass patterns. Robust differential activity to Glass pattern present/absent and dynamic/static stimulus presentation appeared first in V1, followed by V4 and MT-V5 at older ages; there was no reliable distinction between the two extrastriate areas. A similar pattern of results was obtained with the two analysis methods, although MVPA analysis showed reliable differential responses emerging at later ages than GLM. Although BOLD responses to large visual stimuli are detectable, our results with more refined stimuli indicate that global BOLD activity changes as behavioral performance matures. This reflects an hierarchical development of

  16. Solar maximum mission

    International Nuclear Information System (INIS)

    Ryan, J.

    1981-01-01

    By understanding the sun, astrophysicists hope to expand this knowledge to understanding other stars. To study the sun, NASA launched a satellite on February 14, 1980. The project is named the Solar Maximum Mission (SMM). The satellite conducted detailed observations of the sun in collaboration with other satellites and ground-based optical and radio observations until its failure 10 months into the mission. The main objective of the SMM was to investigate one aspect of solar activity: solar flares. A brief description of the flare mechanism is given. The SMM satellite was valuable in providing information on where and how a solar flare occurs. A sequence of photographs of a solar flare taken from SMM satellite shows how a solar flare develops in a particular layer of the solar atmosphere. Two flares especially suitable for detailed observations by a joint effort occurred on April 30 and May 21 of 1980. These flares and observations of the flares are discussed. Also discussed are significant discoveries made by individual experiments

  17. A comparison of measures of boldness and their relationships to survival in young fish.

    Directory of Open Access Journals (Sweden)

    James R White

    Full Text Available Boldness is the propensity of an animal to engage in risky behavior. Many variations of novel-object or novel-environment tests have been used to quantify the boldness of animals, although the relationship between test outcomes has rarely been investigated. Furthermore, the relationship of outcomes to any ecological aspect of fitness is generally assumed, rather than measured directly. Our study is the first to compare how the outcomes of the same test of boldness differ among observers and how different tests of boldness relate to the survival of individuals in the field. Newly-metamorphosed lemon damselfish, Pomacentrus moluccensis, were placed onto replicate patches of natural habitat. Individual behavior was quantified using four tests (composed of a total of 12 different measures of behavior: latency to enter a novel environment, activity in a novel environment, and reactions to threatening and benign novel objects. After behavior was quantified, survival was monitored for two days during which time fish were exposed to natural predators. Variation among observers was low for most of the 12 measures, except distance moved and the threat test (reaction to probe thrust, which displayed unacceptable amounts of inter-observer variation. Overall, the results of the behavioral tests suggested that novel environment and novel object tests quantified similar behaviors, yet these behavioral measures were not interchangeable. Multiple measures of behavior within the context of novel environment or object tests were the most robust way to assess boldness and these measures have a complex relationship with survivorship of young fish in the field. Body size and distance ventured from shelter were the only variables that had a direct and positive relationship with survival.

  18. BOLD cardiovascular magnetic resonance at 3.0 tesla in myocardial ischemia

    Directory of Open Access Journals (Sweden)

    Gebker Rolf

    2010-09-01

    Full Text Available Abstract Background The purpose of this study was to determine the ability of Blood Oxygen Level Dependent (BOLD cardiovascular magnetic resonance (CMR to detect stress-inducible myocardial ischemic reactions in the presence of angiographically significant coronary artery disease (CAD. Methods Forty-six patients (34 men; age 65 ± 9 years, with suspected or known coronary artery disease underwent CMR at 3Tesla prior to clinically indicated invasive coronary angiography. BOLD CMR was performed in 3 short axis slices of the heart at rest and during adenosine stress (140 μg/kg/min followed by late gadolinium enhancement (LGE imaging. In all 16 standard myocardial segments, T2* values were derived at rest and under adenosine stress. Quantitative coronary angiography served as the standard of reference and defined normal myocardial segments (i.e. all 16 segments in patients without any CAD, ischemic segments (i.e. supplied by a coronary artery with ≥50% luminal narrowing and non-ischemic segments (i.e. supplied by a non-significantly stenosed coronary artery in patients with significant CAD. Results Coronary angiography demonstrated significant CAD in 23 patients. BOLD CMR at rest revealed significantly lower T2* values for ischemic segments (26.7 ± 11.6 ms compared to normal (31.9 ± 11.9 ms; p Conclusions Rest and stress BOLD CMR at 3Tesla proved feasible and differentiated between ischemic, non-ischemic, and normal myocardial segments in a clinical patient population. BOLD CMR during vasodilator stress identified patients with significant CAD.

  19. Mapping transient hyperventilation induced alterations with estimates of the multi-scale dynamics of BOLD signal.

    Directory of Open Access Journals (Sweden)

    Vesa J Kiviniemi

    2009-07-01

    Full Text Available Temporal blood oxygen level dependent (BOLD contrast signals in functional MRI during rest may be characterized by power spectral distribution (PSD trends of the form 1/f α. Trends with 1/f characteristics comprise fractal properties with repeating oscillation patterns in multiple time scales. Estimates of the fractal properties enable the quantification of phenomena that may otherwise be difficult to measure, such as transient, non-linear changes. In this study it was hypothesized that the fractal metrics of 1/f BOLD signal trends can map changes related to dynamic, multi-scale alterations in cerebral blood flow (CBF after a transient hyperventilation challenge. Twenty-three normal adults were imaged in a resting-state before and after hyperventilation. Different variables (1/f trend constant α, fractal dimension Df, and, Hurst exponent H characterizing the trends were measured from BOLD signals. The results show that fractal metrics of the BOLD signal follow the fractional Gaussian noise model, even during the dynamic CBF change that follows hyperventilation. The most dominant effect on the fractal metrics was detected in grey matter, in line with previous hyperventilation vaso-reactivity studies. The α was able to differentiate also blood vessels from grey matter changes. Df was most sensitive to grey matter. H correlated with default mode network areas before hyperventilation but this pattern vanished after hyperventilation due to a global increase in H. In the future, resting-state fMRI combined with fractal metrics of the BOLD signal may be used for analyzing multi-scale alterations of cerebral blood flow.

  20. Mapping Transient Hyperventilation Induced Alterations with Estimates of the Multi-Scale Dynamics of BOLD Signal.

    Science.gov (United States)

    Kiviniemi, Vesa; Remes, Jukka; Starck, Tuomo; Nikkinen, Juha; Haapea, Marianne; Silven, Olli; Tervonen, Osmo

    2009-01-01

    Temporal blood oxygen level dependent (BOLD) contrast signals in functional MRI during rest may be characterized by power spectral distribution (PSD) trends of the form 1/f(alpha). Trends with 1/f characteristics comprise fractal properties with repeating oscillation patterns in multiple time scales. Estimates of the fractal properties enable the quantification of phenomena that may otherwise be difficult to measure, such as transient, non-linear changes. In this study it was hypothesized that the fractal metrics of 1/f BOLD signal trends can map changes related to dynamic, multi-scale alterations in cerebral blood flow (CBF) after a transient hyperventilation challenge. Twenty-three normal adults were imaged in a resting-state before and after hyperventilation. Different variables (1/f trend constant alpha, fractal dimension D(f), and, Hurst exponent H) characterizing the trends were measured from BOLD signals. The results show that fractal metrics of the BOLD signal follow the fractional Gaussian noise model, even during the dynamic CBF change that follows hyperventilation. The most dominant effect on the fractal metrics was detected in grey matter, in line with previous hyperventilation vaso-reactivity studies. The alpha was able to differentiate also blood vessels from grey matter changes. D(f) was most sensitive to grey matter. H correlated with default mode network areas before hyperventilation but this pattern vanished after hyperventilation due to a global increase in H. In the future, resting-state fMRI combined with fractal metrics of the BOLD signal may be used for analyzing multi-scale alterations of cerebral blood flow.

  1. Amplitude Effects on Thrust Production for Undulatory Swimmers

    Science.gov (United States)

    Gater, Brittany; Bayandor, Javid

    2017-11-01

    Biological systems offer novel and efficient solutions to many engineering applications, including marine propulsion. It is of interest to determine how fish interact with the water around them, and how best to utilize the potential their methods offer. A stingray-like fin was chosen for analysis due to the maneuverability and versatility of stingrays. The stingray fin was modeled in 2D as a sinusoidal wave with an amplitude increasing from zero at the leading edge to a maximum at the trailing edge. Using this model, a parametric study was performed to examine the effects of the fin on surrounding water in CFD simulations. The results were analyzed both qualitatively, in terms of the pressure contours on the fin and vorticity in the trailing wake, and quantitatively, in terms of the resultant forces on the fin. The amplitude was found to have no effect on the average thrust during steady swimming, when the wave speed on the fin was approximately equal to the swimming speed. However, amplitude was shown to have a significant effect on thrust production when the fin was accelerating. This finding suggests that for undulatory swimmers, amplitude is less useful for controlling swimming speed, but can be used to great effect for augmenting thrust during acceleration.

  2. On the singularities of massive superstring amplitudes

    International Nuclear Information System (INIS)

    Foda, O.

    1987-01-01

    Superstring one-loop amplitudes with massive external states are shown to be in general ill-defined due to internal on-shell propagators. However, we argue that since any massive string state (in the uncompactified theory) has a finite lifetime to decay into massless particles, such amplitudes are not terms in the perturbative expansion of physical S-matrix elements: These can be defined only with massless external states. Consistent massive amplitudes repuire an off-shell formalism. (orig.)

  3. On the singularities of massive superstring amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Foda, O.

    1987-06-04

    Superstring one-loop amplitudes with massive external states are shown to be in general ill-defined due to internal on-shell propagators. However, we argue that since any massive string state (in the uncompactified theory) has a finite lifetime to decay into massless particles, such amplitudes are not terms in the perturbative expansion of physical S-matrix elements: These can be defined only with massless external states. Consistent massive amplitudes repuire an off-shell formalism.

  4. New relations for graviton-matter amplitudes

    CERN Multimedia

    CERN. Geneva

    2018-01-01

    I report on recent progress in finding compact expressions for scattering amplitudes involving gravitons and gluons as well as massive scalar and fermionic matter particles. At tree level the single graviton emission amplitudes may be expressed as linear combination of purely non-gravitational ones. At the one-loop level recent results on all four point Einstein-Yang-Mills amplitudes with at most one opposite helicity state using unitarity methods are reported. 

  5. Analytical properties of multiple production amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Medvedev, B V; Pavlov, V P; Polivanov, M K; Sukhanov, A D [Gosudarstvennyj Komitet po Ispol' zovaniyu Atomnoj Ehnergii SSSR, Moscow. Inst. Teoreticheskoj i Ehksperimental' noj Fiziki; AN SSSR, Moscow. Matematicheskij Inst.)

    1984-05-01

    Local analytical properties of amplitudes 2..-->..3 and 2..-->..4 are studied. The amplitudes are shown to be analytical functions of total and partial energies at fixed momentum transfers in the neighbourhood of any physical point on the energy shell 14 (for the 2..-->..3 case) and 242 (for the 2..-->..4 case) boundary values are expressed through the amplitudes of real processes.

  6. DVCS amplitude with kinematical twist-3 terms

    International Nuclear Information System (INIS)

    Radyushkin, A.V.; Weiss, C.

    2000-01-01

    The authors compute the amplitude of deeply virtual Compton scattering (DVCS) using the calculus of QCD string operators in coordinate representation. To restore the electromagnetic gauge invariance (transversality) of the twist-2 amplitude they include the operators of twist-3 which appear as total derivatives of twist-2 operators. The results are equivalent to a Wandzura-Wilczek approximation for twist-3 skewed parton distributions. They find that this approximation gives a finite result for the amplitude of a longitudinally polarized virtual photon, while the amplitude for transverse polarization is divergent, i.e., factorization breaks down in this term

  7. Amplitude structure of off-shell processes

    International Nuclear Information System (INIS)

    Fearing, H.W.; Goldstein, G.R.; Moravcsik, M.J.

    1984-01-01

    The structure of M matrices, or scattering amplitudes, and of potentials for off-shell processes is discussed with the objective of determining how one can obtain information on off-shell amplitudes of a process in terms of the physical observables of a larger process in which the first process is embedded. The procedure found is inevitably model dependent, but within a particular model for embedding, a determination of the physically measurable amplitudes of the larger process is able to yield a determination of the off-shell amplitudes of the embedded process

  8. Pulse amplitude and frequency effects in a pulsed packed column

    International Nuclear Information System (INIS)

    Russell, S.H.

    1954-04-01

    A study has been made of the effect on the efficiency and capacity of applying pulses of varying amplitude and frequency to a packed column. In the efficiency studies, the maximum efficiency was obtained with a pulse having an amplitude of 3/8'' and a frequency of 140 cycles per minute. Under these conditions, the column was about five times as efficient as a simple packed column. Two general types of results were obtained in the capacity studies. Under certain conditions, the capacity increased over that of a simple packed column, but under others, it decreased. Some of the factors causing this were investigated but the fundamental reasons were not determined due to a lack of personnel for the necessary experiments. (author)

  9. Pulse amplitude and frequency effects in a pulsed packed column

    Energy Technology Data Exchange (ETDEWEB)

    Russell, S H

    1954-04-15

    A study has been made of the effect on the efficiency and capacity of applying pulses of varying amplitude and frequency to a packed column. In the efficiency studies, the maximum efficiency was obtained with a pulse having an amplitude of 3/8'' and a frequency of 140 cycles per minute. Under these conditions, the column was about five times as efficient as a simple packed column. Two general types of results were obtained in the capacity studies. Under certain conditions, the capacity increased over that of a simple packed column, but under others, it decreased. Some of the factors causing this were investigated but the fundamental reasons were not determined due to a lack of personnel for the necessary experiments. (author)

  10. Working memory in volunteers and schizophrenics using BOLD fMRI; Das Arbeitsgedaechtnis bei Gesunden und bei Schizophrenen: Untersuchungen mit BOLD-fMRT

    Energy Technology Data Exchange (ETDEWEB)

    Giesel, F.L. [Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Abteilung Radiologie (Germany); Deutsches Krebsforschungszentrum (DKFZ), Abteilung Radiologie, Heidelberg (Germany); Hohmann, N. [Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Abteilung Radiologie (Germany); Psychiatrische Universitaetsklinik Heidelberg, Sektion Gerontopsychiatrie (Germany); Seidl, U.; Kress, K.R.; Schoenknecht, P.; Schroeder, J. [Psychiatrische Universitaetsklinik Heidelberg, Sektion Gerontopsychiatrie (Germany); Kauczor, H.-U.; Essig, M. [Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Abteilung Radiologie (Germany)

    2005-02-01

    Functional magnetic resonance imaging uses the blood oxygen level-dependent effect (BOLD MRI) for noninvasive display of cerebral correlatives of cognitive function. The importance for the understanding of physiological and pathological processes is demonstrated by investigations of working memory in schizophrenics and healthy controls. Working memory is involved in processing rather than storage of information and therefore is linked to complex processes such as learning and problem solving. In schizophrenic psychosis, these functions are clearly restricted. Training effects in the working memory task follow an inverse U-shape function, suggesting that cerebral activation reaches a peak before economics of the brain find a more efficient method and activation decreases. (orig.) [German] Die funktionelle Magnetresonanztomographie (fMRT) nutzt den ''blood oxygen level dependent effect'' (BOLD-Effekt) zur nichtinvasiven Darstellung zerebraler Korrelate kognitiver Funktionen. Die Bedeutung dieses Verfahrens fuer das Verstaendnis physiologischer und pathologischer Prozesse wird anhand von Untersuchungen zum Arbeitsgedaechtnis bei Schizophrenen und gesunden Kontrollpersonen verdeutlicht. Das Arbeitsgedaechtnis dient weniger der Speicherung, sondern vielmehr der Verarbeitung von Informationen und ist deshalb in komplexe Prozesse wie Lernen und Problemloesen eingebunden. Im Rahmen schizophrener Psychosen kommt es zu einer deutlichen Einschraenkung dieser Funktionen. Erwartungsgemaess zeigen sich unter Durchfuehrung eines Arbeitsgedaechtnisparadigmas Unterschiede in der zerebralen Aktivitaet, die jedoch bei den Erkrankten unter Therapie prinzipiell reversibel sind. Von Interesse sind auch Trainingseffekte bei Gesunden, wobei eine verminderte Aktivierung nach Training auf eine ''Oekonomisierung'' schliessen laesst. (orig.)

  11. Spatiotopic coding of BOLD signal in human visual cortex depends on spatial attention.

    Directory of Open Access Journals (Sweden)

    Sofia Crespi

    Full Text Available The neural substrate of the phenomenological experience of a stable visual world remains obscure. One possible mechanism would be to construct spatiotopic neural maps where the response is selective to the position of the stimulus in external space, rather than to retinal eccentricities, but evidence for these maps has been inconsistent. Here we show, with fMRI, that when human subjects perform concomitantly a demanding attentive task on stimuli displayed at the fovea, BOLD responses evoked by moving stimuli irrelevant to the task were mostly tuned in retinotopic coordinates. However, under more unconstrained conditions, where subjects could attend easily to the motion stimuli, BOLD responses were tuned not in retinal but in external coordinates (spatiotopic selectivity in many visual areas, including MT, MST, LO and V6, agreeing with our previous fMRI study. These results indicate that spatial attention may play an important role in mediating spatiotopic selectivity.

  12. Hypercapnic normalization of BOLD fMRI: comparison across field strengths and pulse sequences

    DEFF Research Database (Denmark)

    Cohen, Eric R.; Rostrup, Egill; Sidaros, Karam

    2004-01-01

    to be more accurately localized and quantified based on changes in venous blood oxygenation alone. The normalized BOLD signal induced by the motor task was consistent across different magnetic fields and pulse sequences, and corresponded well with cerebral blood flow measurements. Our data suggest...... size, as well as experimental, such as pulse sequence and static magnetic field strength (B(0)). Thus, it is difficult to compare task-induced fMRI signals across subjects, field strengths, and pulse sequences. This problem can be overcome by normalizing the neural activity-induced BOLD fMRI response...... for global stimulation, subjects breathed a 5% CO(2) gas mixture. Under all conditions, voxels containing primarily large veins and those containing primarily active tissue (i.e., capillaries and small veins) showed distinguishable behavior after hypercapnic normalization. This allowed functional activity...

  13. Bold Ideas for the 4th H in 4-H: Teen Identified Concerns and Actions

    OpenAIRE

    Virginia Brown; Bonnie Braun; JoAnne Leatherman

    2015-01-01

    This article summarizes a literature review; teen-identified health concerns and issues; and teen bold ideas for actions. Findings from the National 4-H Council and Molina Healthcare Teens Take on Health initiative are provided and implications for 4-H programming tied to the new Cooperative Extension National Framework for Health and Wellness are addressed. The article is intended as background for Extension educators, volunteers and administrators as they review the 4-H Healthy Living Missi...

  14. Electrophysiological correlates of the BOLD signal for EEG-informed fMRI

    Science.gov (United States)

    Murta, Teresa; Leite, Marco; Carmichael, David W; Figueiredo, Patrícia; Lemieux, Louis

    2015-01-01

    Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are important tools in cognitive and clinical neuroscience. Combined EEG–fMRI has been shown to help to characterise brain networks involved in epileptic activity, as well as in different sensory, motor and cognitive functions. A good understanding of the electrophysiological correlates of the blood oxygen level-dependent (BOLD) signal is necessary to interpret fMRI maps, particularly when obtained in combination with EEG. We review the current understanding of electrophysiological–haemodynamic correlates, during different types of brain activity. We start by describing the basic mechanisms underlying EEG and BOLD signals and proceed by reviewing EEG-informed fMRI studies using fMRI to map specific EEG phenomena over the entire brain (EEG–fMRI mapping), or exploring a range of EEG-derived quantities to determine which best explain colocalised BOLD fluctuations (local EEG–fMRI coupling). While reviewing studies of different forms of brain activity (epileptic and nonepileptic spontaneous activity; cognitive, sensory and motor functions), a significant attention is given to epilepsy because the investigation of its haemodynamic correlates is the most common application of EEG-informed fMRI. Our review is focused on EEG-informed fMRI, an asymmetric approach of data integration. We give special attention to the invasiveness of electrophysiological measurements and the simultaneity of multimodal acquisitions because these methodological aspects determine the nature of the conclusions that can be drawn from EEG-informed fMRI studies. We emphasise the advantages of, and need for, simultaneous intracranial EEG–fMRI studies in humans, which recently became available and hold great potential to improve our understanding of the electrophysiological correlates of BOLD fluctuations. PMID:25277370

  15. Using CO5BOLD models to predict the effects of granulation on colours .

    Science.gov (United States)

    Bonifacio, P.; Caffau, E.; Ludwig, H.-G.; Steffen, M.; Castelli, F.; Gallagher, A. J.; Prakapavičius, D.; Kučinskas, A.; Cayrel, R.; Freytag, B.; Plez, B.; Homeier, D.

    In order to investigate the effects of granulation on fluxes and colours, we computed the emerging fluxes from the models in the CO5BOLD grid with metallicities [M/H]=0.0,-1.0,-2.0 and -3.0. These fluxes have been used to compute colours in different photometric systems. We explain here how our computations have been performed and provide some results.

  16. Teacherpreneurs: a bold brand of teacher leadership for 21st-century teaching and learning.

    Science.gov (United States)

    Berry, Barnett

    2013-04-19

    Challenges facing our public schools demand a bold brand of teacher leadership. Teacherpreneurs, effective teachers who teach students regularly but also incubate and execute the kinds of policies and pedagogies students deserve, represent a new culture of training and ingenuity. Teachers who lead outside the classroom but do not lose their connection to students are best positioned to develop and disseminate best policies and practices for 21st-century teaching and learning.

  17. Interictal functional connectivity of human epileptic networks assessed by intracerebral EEG and BOLD signal fluctuations.

    Directory of Open Access Journals (Sweden)

    Gaelle Bettus

    Full Text Available In this study, we aimed to demonstrate whether spontaneous fluctuations in the blood oxygen level dependent (BOLD signal derived from resting state functional magnetic resonance imaging (fMRI reflect spontaneous neuronal activity in pathological brain regions as well as in regions spared by epileptiform discharges. This is a crucial issue as coherent fluctuations of fMRI signals between remote brain areas are now widely used to define functional connectivity in physiology and in pathophysiology. We quantified functional connectivity using non-linear measures of cross-correlation between signals obtained from intracerebral EEG (iEEG and resting-state functional MRI (fMRI in 5 patients suffering from intractable temporal lobe epilepsy (TLE. Functional connectivity was quantified with both modalities in areas exhibiting different electrophysiological states (epileptic and non affected regions during the interictal period. Functional connectivity as measured from the iEEG signal was higher in regions affected by electrical epileptiform abnormalities relative to non-affected areas, whereas an opposite pattern was found for functional connectivity measured from the BOLD signal. Significant negative correlations were found between the functional connectivities of iEEG and BOLD signal when considering all pairs of signals (theta, alpha, beta and broadband and when considering pairs of signals in regions spared by epileptiform discharges (in broadband signal. This suggests differential effects of epileptic phenomena on electrophysiological and hemodynamic signals and/or an alteration of the neurovascular coupling secondary to pathological plasticity in TLE even in regions spared by epileptiform discharges. In addition, indices of directionality calculated from both modalities were consistent showing that the epileptogenic regions exert a significant influence onto the non epileptic areas during the interictal period. This study shows that functional

  18. Distinct BOLD activation profiles following central and peripheral oxytocin administration in awake rats

    Directory of Open Access Journals (Sweden)

    Craig F Ferris

    2015-09-01

    Full Text Available A growing body of literature has suggested that intranasal oxytocin (OT or other systemic routes of administration can alter prosocial behavior, presumably by directly activating OT sensitive neural circuits in the brain. Yet there is no clear evidence that OT given peripherally can cross the blood-brain-barrier at levels sufficient to engage the OT receptor. To address this issue we examined changes in blood oxygen level dependent (BOLD signal intensity in response to peripheral OT injections (0.1, 0.5 or 2.5 mg/kg during functional magnetic resonance (fMRI in awake rats imaged at 7.0 tesla. These data were compared to OT (1ug/5 µl given directly to the brain via the lateral cerebroventricle. Using a 3D annotated MRI atlas of the rat brain segmented into 171 brain areas and computational analysis we reconstructed the distributed integrated neural circuits identified with BOLD fMRI following central and peripheral OT. Both routes of administration caused significant changes in BOLD signal within the first 10 min of administration. As expected, central OT activated a majority of brain areas known to express a high density of OT receptors e.g., lateral septum, subiculum, shell of the accumbens, bed nucleus of the stria terminalis. This profile of activation was not matched by peripheral OT. The change in BOLD signal to peripheral OT did not show any discernible dose-response. Interestingly, peripheral OT affected all subdivisions of the olfactory bulb, in addition to the cerebellum and several brainstem areas relevant to the autonomic nervous system, including the solitary tract nucleus. The results from this imaging study do not support a direct central action of peripheral OT on the brain. Instead, the patterns of brain activity suggest that peripheral OT may interact at the level of the olfactory bulb and through sensory afferents from the autonomic nervous system to influence brain activity.

  19. Detection of Acute Tubular Necrosis Using Blood Oxygenation Level-Dependent (BOLD MRI

    Directory of Open Access Journals (Sweden)

    Frederic Bauer

    2017-12-01

    Full Text Available Background/Aims: To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI measures tissue oxygenation based on the transverse relaxation rate (R2*. The present study investigates whether BOLD MRI can assess tubular function using a tubule-specific pharmacological maneuver. Methods: Cross sectional study with 28 participants including 9 subjects with ATN-induced acute kidney injury (AKI, 9 healthy controls, and 10 subjects with nephron sparing tumor resection (NSS with clamping of the renal artery serving as a model of ischemia/reperfusion (I/R-induced subclinical ATN (median clamping time 15 min, no significant decrease of eGFR, p=0.14. BOLD MRI was performed before and 5, 7, and 10 min after intravenous administration of 40 mg furosemide. Results: Urinary neutrophil gelatinase-associated lipocalin was significantly higher in ATN-induced AKI and NSS subjects than in healthy controls (p=0.03 and p=0.01, respectively. Before administration of furosemide, absolute medullary R2*, cortical R2*, and medullary/cortical R2* ratio did not significantly differ between ATN-induced AKI vs. healthy controls and between NSS-I/R vs. contralateral healthy kidneys (p>0.05 each. Furosemide led to a significant decrease in the medullary and cortical R2* of healthy subjects and NSS contralateral kidneys (p<0.05 each, whereas there was no significant change of R2* in ATN-induced AKI and the NSS-I/R kidneys (p>0.05 each. Conclusion: BOLD-MRI is able to detect even mild tubular injury but necessitates a tubule-specific pharmacological maneuver, e.g. blocking the Na+-K+-2Cl- transporter by furosemide.

  20. Ultrafast bold fMRI using single-shot spin-echo echo planar imaging

    Directory of Open Access Journals (Sweden)

    Boujraf Said

    2009-01-01

    Full Text Available The choice of imaging parameters for functional MRI can have an impact on the accuracy of functional localization by affecting the image quality and the degree of blood oxygenation-dependent (BOLD contrast achieved. By improving sampling efficiency, parallel acquisition techniques such as sensitivity encoding (SENSE have been used to shorten readout trains in single-shot (SS echo planar imaging (EPI. This has been applied to susceptibility artifact reduction and improving spatial resolution. SENSE together with single-shot spin-echo (SS-SE imaging may also reduce off-resonance artifacts. The goal of this work was to investigate the BOLD response of a SENSE-adapted SE-EPI on a three Tesla scanner. Whole-brain fMRI studies of seven healthy right hand-dominant volunteers were carried out in a three Tesla scanner. fMRI was performed using an SS-SE EPI sequence with SENSE. The data was processed using statistical parametric mapping. Both, group and individual subject data analyses were performed. Individual average percentage and maximal percentage signal changes attributed to the BOLD effect in M1 were calculated for all the subjects as a function of echo time. Corresponding activation maps and the sizes of the activated clusters were also calculated. Our results show that susceptibility artifacts were reduced with the use of SENSE; and the acquired BOLD images were free of the typical quadrature artifacts of SS-EPI. Such measures are crucial at high field strengths. SS SE-EPI with SENSE offers further benefits in this regard and is more specific for oxygenation changes in the microvasculature bed. Functional brain activity can be investigated with the help of single-shot spin echo EPI using SENSE at high magnetic fields.

  1. Speech Enhancement by MAP Spectral Amplitude Estimation Using a Super-Gaussian Speech Model

    Directory of Open Access Journals (Sweden)

    Lotter Thomas

    2005-01-01

    Full Text Available This contribution presents two spectral amplitude estimators for acoustical background noise suppression based on maximum a posteriori estimation and super-Gaussian statistical modelling of the speech DFT amplitudes. The probability density function of the speech spectral amplitude is modelled with a simple parametric function, which allows a high approximation accuracy for Laplace- or Gamma-distributed real and imaginary parts of the speech DFT coefficients. Also, the statistical model can be adapted to optimally fit the distribution of the speech spectral amplitudes for a specific noise reduction system. Based on the super-Gaussian statistical model, computationally efficient maximum a posteriori speech estimators are derived, which outperform the commonly applied Ephraim-Malah algorithm.

  2. Automation of loop amplitudes in numerical approach

    International Nuclear Information System (INIS)

    Fujimoto, J.; Ishikawa, T.; Shimizu, Y.; Kato, K.; Nakazawa, N.; Kaneko, T.

    1997-01-01

    An automatic calculating system GRACE-L1 of one-loop Feynman amplitude is reviewed. This system can be applied to 2 to 2-body one-loop processes. A sample calculation of 2 to 3-body one-loop amplitudes is also presented. (orig.)

  3. On the singularities of massive superstring amplitudes

    NARCIS (Netherlands)

    Foda, O.

    1987-01-01

    Superstring one-loop amplitudes with massive external states are shown to be in general ill-defined due to internal on-shell propagators. However, we argue that since any massive string state (in the uncompactified theory) has a finite lifetime to decay into massless particles, such amplitudes are

  4. Scattering Amplitudes via Algebraic Geometry Methods

    DEFF Research Database (Denmark)

    Søgaard, Mads

    Feynman diagrams. The study of multiloop scattering amplitudes is crucial for the new era of precision phenomenology at the Large Hadron Collider (LHC) at CERN. Loop-level scattering amplitudes can be reduced to a basis of linearly independent integrals whose coefficients are extracted from generalized...

  5. Full amplitude models of 15 day Cepheids

    International Nuclear Information System (INIS)

    Cogan, B.C.; Cox, A.N.; King, D.S.

    1980-01-01

    Numerical models of Cepheids have been computed with a range of effective temperatures and compositions. The amplitudes increase if the helium abundance increases or if the effective temperature decreases. The latter effect is contrary to observational data. The models also exhibit velocity amplitudes which are much lower than those observed

  6. Helicity amplitudes for matter-coupled gravity

    International Nuclear Information System (INIS)

    Aldrovandi, R.; Novaes, S.F.; Spehler, D.

    1992-07-01

    The Weyl-van der Waerden spinor formalism is applied to the evaluation of helicity invariant amplitudes in the framework of linearized gravitation. The graviton couplings to spin-0, 1 - 2 , 1, and 3 - 2 particles are given, and, to exhibit the reach of this method, the helicity amplitudes for the process electron + positron → photon + graviton are obtained. (author)

  7. Socially bold personality in the real communication and Internet communication: the analysis of representations of people of the different age

    Directory of Open Access Journals (Sweden)

    Pogodina A. V.

    2017-03-01

    Full Text Available The article is concerned with the results of the study, subject of which is the submis- sion of the respondents of the different age groups about the social and bold personality. Required property of the respondents was the presence in the Internet environment and participation in various social networks. They assessed social and bold personal- ity in such contexts of communication, as real communication and Internet communication. Analyses were undertaken to determine the structural and content features of emotional and semantic representations of the phenomenon of the social and bold personality, depending on the context of communication, but also the detection of age-sensitive representations of the young respondents (19—35 years, middle-aged respondents (36-55 years and older respondents (from 56 to 70 years. The concept of the “social and bold personality in real communion” is shown to have a high semantic relevance, strongly marked positive emotional coloration and a similar factor structure for respondents of all age groups. The concept of the “social and bold personality in online communication” with a high semantic significance in the perception of the young respondents moves into a zone of moderate and semantic importance in representations of the middle-aged and older respondents. In representations of the respondents of all age groups, the attractiveness of the "social and bold personality in Internet communication" is less than in comparison with the "social and bold personality in the real communication". The age-specific of the social representations about social and bold personality in the real and virtual communication has been analysed in detail.

  8. The effect of sleep deprivation on BOLD activity elicited by a divided attention task.

    Science.gov (United States)

    Jackson, Melinda L; Hughes, Matthew E; Croft, Rodney J; Howard, Mark E; Crewther, David; Kennedy, Gerard A; Owens, Katherine; Pierce, Rob J; O'Donoghue, Fergal J; Johnston, Patrick

    2011-06-01

    Sleep loss, widespread in today's society and associated with a number of clinical conditions, has a detrimental effect on a variety of cognitive domains including attention. This study examined the sequelae of sleep deprivation upon BOLD fMRI activation during divided attention. Twelve healthy males completed two randomized sessions; one after 27 h of sleep deprivation and one after a normal night of sleep. During each session, BOLD fMRI was measured while subjects completed a cross-modal divided attention task (visual and auditory). After normal sleep, increased BOLD activation was observed bilaterally in the superior frontal gyrus and the inferior parietal lobe during divided attention performance. Subjects reported feeling significantly more sleepy in the sleep deprivation session, and there was a trend towards poorer divided attention task performance. Sleep deprivation led to a down regulation of activation in the left superior frontal gyrus, possibly reflecting an attenuation of top-down control mechanisms on the attentional system. These findings have implications for understanding the neural correlates of divided attention and the neurofunctional changes that occur in individuals who are sleep deprived.

  9. Abnormal Striatal BOLD Responses to Reward Anticipation and Reward Delivery in ADHD

    Science.gov (United States)

    Furukawa, Emi; Bado, Patricia; Tripp, Gail; Mattos, Paulo; Wickens, Jeff R.; Bramati, Ivanei E.; Alsop, Brent; Ferreira, Fernanda Meireles; Lima, Debora; Tovar-Moll, Fernanda; Sergeant, Joseph A.; Moll, Jorge

    2014-01-01

    Altered reward processing has been proposed to contribute to the symptoms of attention deficit hyperactivity disorder (ADHD). The neurobiological mechanism underlying this alteration remains unclear. We hypothesize that the transfer of dopamine release from reward to reward-predicting cues, as normally observed in animal studies, may be deficient in ADHD. Functional magnetic resonance imaging (fMRI) was used to investigate striatal responses to reward-predicting cues and reward delivery in a classical conditioning paradigm. Data from 14 high-functioning and stimulant-naïve young adults with elevated lifetime symptoms of ADHD (8 males, 6 females) and 15 well-matched controls (8 males, 7 females) were included in the analyses. During reward anticipation, increased blood-oxygen-level-dependent (BOLD) responses in the right ventral and left dorsal striatum were observed in controls, but not in the ADHD group. The opposite pattern was observed in response to reward delivery; the ADHD group demonstrated significantly greater BOLD responses in the ventral striatum bilaterally and the left dorsal striatum relative to controls. In the ADHD group, the number of current hyperactivity/impulsivity symptoms was inversely related to ventral striatal responses during reward anticipation and positively associated with responses to reward. The BOLD response patterns observed in the striatum are consistent with impaired predictive dopamine signaling in ADHD, which may explain altered reward-contingent behaviors and symptoms of ADHD. PMID:24586543

  10. Using BOLD imaging to measure renal oxygenation dynamics in rats injected with diuretics

    International Nuclear Information System (INIS)

    Kusakabe, Yoshinori; Matsushita, Taro; Honda, Saori; Okada, Sakie; Murase, Kenya

    2010-01-01

    We used blood oxygenation level-dependent magnetic resonance imaging (BOLD MRI) to measure renal oxygenation dynamics in rats injected with diuretics and evaluated diuretic effect on renal oxygenation. We performed BOLD MRI studies in 32 rats using a 1.5-tesla MR imaging system for animal experiments. We intravenously injected rats with saline (n=7), furosemide (n=7), acetazolamide (n=6), or mannitol (n=6). For controls, 6 rats were not injected with drugs. We estimated the apparent transverse relaxation rate (R 2 *) from the apparent transverse relaxation time (T 2 *)-weighted images and measured the time course of R 2 * at 4-min intervals over approximately 30 min. Compared with preadministration values, the R 2 * value did not change significantly in either the cortex or medulla in the control and mannitol groups but decreased significantly in the saline group; the R 2 * value significantly decreased in the medulla but did not change significantly in the cortex in the furosemide group; and the R 2 * value significantly increased in the medulla and significantly decreased in the cortex in the acetazolamide group. Our study results suggest that BOLD MRI is useful for evaluating the dynamics of renal oxygenation in response to various diuretics in the renal cortex and in the medulla. (author)

  11. New relations for gauge-theory amplitudes

    International Nuclear Information System (INIS)

    Bern, Z.; Carrasco, J. J. M.; Johansson, H.

    2008-01-01

    We present an identity satisfied by the kinematic factors of diagrams describing the tree amplitudes of massless gauge theories. This identity is a kinematic analog of the Jacobi identity for color factors. Using this we find new relations between color-ordered partial amplitudes. We discuss applications to multiloop calculations via the unitarity method. In particular, we illustrate the relations between different contributions to a two-loop four-point QCD amplitude. We also use this identity to reorganize gravity tree amplitudes diagram by diagram, offering new insight into the structure of the Kawai-Lewellen-Tye (KLT) relations between gauge and gravity tree amplitudes. This insight leads to similar but novel relations. We expect this to be helpful in higher-loop studies of the ultraviolet properties of gravity theories.

  12. Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response.

    Science.gov (United States)

    Hallac, Rami R; Zhou, Heling; Pidikiti, Rajesh; Song, Kwang; Stojadinovic, Strahinja; Zhao, Dawen; Solberg, Timothy; Peschke, Peter; Mason, Ralph P

    2014-05-01

    To examine the potential use of blood oxygenation level dependent (BOLD) and tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and predict radiation response. BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n = 9), subsequent (19) F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n = 13) growth delay following a single dose of 30 Gy was compared with preirradiation BOLD and TOLD assessments. Oxygen (100%O2 ) and carbogen (95%O2 /5%CO2 ) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative (19) F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay. These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2 . Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation. Copyright © 2013 Wiley Periodicals, Inc.

  13. Correlation of BOLD Signal with Linear and Nonlinear Patterns of EEG in Resting State EEG-Informed fMRI

    Directory of Open Access Journals (Sweden)

    Galina V. Portnova

    2018-01-01

    Full Text Available Concurrent EEG and fMRI acquisitions in resting state showed a correlation between EEG power in various bands and spontaneous BOLD fluctuations. However, there is a lack of data on how changes in the complexity of brain dynamics derived from EEG reflect variations in the BOLD signal. The purpose of our study was to correlate both spectral patterns, as linear features of EEG rhythms, and nonlinear EEG dynamic complexity with neuronal activity obtained by fMRI. We examined the relationships between EEG patterns and brain activation obtained by simultaneous EEG-fMRI during the resting state condition in 25 healthy right-handed adult volunteers. Using EEG-derived regressors, we demonstrated a substantial correlation of BOLD signal changes with linear and nonlinear features of EEG. We found the most significant positive correlation of fMRI signal with delta spectral power. Beta and alpha spectral features had no reliable effect on BOLD fluctuation. However, dynamic changes of alpha peak frequency exhibited a significant association with BOLD signal increase in right-hemisphere areas. Additionally, EEG dynamic complexity as measured by the HFD of the 2–20 Hz EEG frequency range significantly correlated with the activation of cortical and subcortical limbic system areas. Our results indicate that both spectral features of EEG frequency bands and nonlinear dynamic properties of spontaneous EEG are strongly associated with fluctuations of the BOLD signal during the resting state condition.

  14. Amplitude scintillations of ATS-6 radio signals in Lannion

    International Nuclear Information System (INIS)

    Cornec, J.P.

    1978-01-01

    The paper reports the results of a study of the scintillations observed on the amplitude of signal transmitted by the geostationary satellite ATS-6 on 40, 140, and 360 MHz, received at Lannion, France. Diffraction patterns caused bubbles of irregularities are studied and found to be mainly a summer phenomenon. It is concluded that there is a great increase in frequency occurrence and in the strength of scintillations from winter to summer, and that for the whole observation period, scintillation is mainly a nighttime pheonomenon, reaching its maximum activity at 2100-2200

  15. Random Telegraph Signal Amplitudes in Sub 100 nm (Decanano) MOSFETs: A 3D 'Atomistic' Simulation Study

    Science.gov (United States)

    Asenov, Asen; Balasubramaniam, R.; Brown, A. R.; Davies, J. H.; Saini, Subhash

    2000-01-01

    In this paper we use 3D simulations to study the amplitudes of random telegraph signals (RTS) associated with the trapping of a single carrier in interface states in the channel of sub 100 nm (decanano) MOSFETs. Both simulations using continuous doping charge and random discrete dopants in the active region of the MOSFETs are presented. We have studied the dependence of the RTS amplitudes on the position of the trapped charge in the channel and on the device design parameters. We have observed a significant increase in the maximum RTS amplitude when discrete random dopants are employed in the simulations.

  16. Effects of strength training on mechanomyographic amplitude

    International Nuclear Information System (INIS)

    DeFreitas, Jason M; Beck, Travis W; Stock, Matt S

    2012-01-01

    The aim of the present study was to determine if the patterns of mechanomyographic (MMG) amplitude across force would change with strength training. Twenty-two healthy men completed an 8-week strength training program. During three separate testing visits (pre-test, week 4, and week 8), the MMG signal was detected from the vastus lateralis as the subjects performed isometric step muscle actions of the leg extensors from 10–100% of maximal voluntary contraction (MVC). During pre-testing, the MMG amplitude increased linearly with force to 66% MVC and then plateaued. Conversely, weeks 4 and 8 demonstrated an increase in MMG amplitude up to ∼85% of the subject's original MVC before plateauing. Furthermore, seven of the ten force levels (30–60% and 80–100%) showed a significant decrease in mean MMG amplitude values after training, which consequently led to a decrease in the slope of the MMG amplitude/force relationship. The decreases in MMG amplitude at lower force levels are indicative of hypertrophy, since fewer motor units would be required to produce the same absolute force if the motor units increased in size. However, despite the clear changes in the mean values, analyses of individual subjects revealed that only 55% of the subjects demonstrated a significant decrease in the slope of the MMG amplitude/force relationship. (paper)

  17. Credal Networks under Maximum Entropy

    OpenAIRE

    Lukasiewicz, Thomas

    2013-01-01

    We apply the principle of maximum entropy to select a unique joint probability distribution from the set of all joint probability distributions specified by a credal network. In detail, we start by showing that the unique joint distribution of a Bayesian tree coincides with the maximum entropy model of its conditional distributions. This result, however, does not hold anymore for general Bayesian networks. We thus present a new kind of maximum entropy models, which are computed sequentially. ...

  18. Holographic corrections to meson scattering amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Armoni, Adi; Ireson, Edwin, E-mail: 746616@swansea.ac.uk

    2017-06-15

    We compute meson scattering amplitudes using the holographic duality between confining gauge theories and string theory, in order to consider holographic corrections to the Veneziano amplitude and associated higher-point functions. The generic nature of such computations is explained, thanks to the well-understood nature of confining string backgrounds, and two different examples of the calculation in given backgrounds are used to illustrate the details. The effect we discover, whilst only qualitative, is re-obtainable in many such examples, in four-point but also higher point amplitudes.

  19. Amplitude-Mode Dynamics of Polariton Condensates

    International Nuclear Information System (INIS)

    Brierley, R. T.; Littlewood, P. B.; Eastham, P. R.

    2011-01-01

    We study the stability of collective amplitude excitations in nonequilibrium polariton condensates. These excitations correspond to renormalized upper polaritons and to the collective amplitude modes of atomic gases and superconductors. They would be present following a quantum quench or could be created directly by resonant excitation. We show that uniform amplitude excitations are unstable to the production of excitations at finite wave vectors, leading to the formation of density-modulated phases. The physical processes causing the instabilities can be understood by analogy to optical parametric oscillators and the atomic Bose supernova.

  20. Hidden simplicity of gauge theory amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Drummond, J M, E-mail: drummond@lapp.in2p3.f [LAPTH, Universite de Savoie, CNRS, B.P. 110, F-74941 Annecy-le-Vieux, Cedex (France)

    2010-11-07

    These notes were given as lectures at the CERN Winter School on Supergravity, Strings and Gauge Theory 2010. We describe the structure of scattering amplitudes in gauge theories, focussing on the maximally supersymmetric theory to highlight the hidden symmetries which appear. Using the Britto, Cachzo, Feng and Witten (BCFW) recursion relations we solve the tree-level S-matrix in N=4 super Yang-Mills theory and describe how it produces a sum of invariants of a large symmetry algebra. We review amplitudes in the planar theory beyond tree level, describing the connection between amplitudes and Wilson loops, and discuss the implications of the hidden symmetries.

  1. Analytic continuation of dual Feynman amplitudes

    International Nuclear Information System (INIS)

    Bleher, P.M.

    1981-01-01

    A notion of dual Feynman amplitude is introduced and a theorem on the existence of analytic continuation of this amplitude from the convergence domain to the whole complex is proved. The case under consideration corresponds to massless power propagators and the analytic continuation is constructed on the propagators powers. Analytic continuation poles and singular set of external impulses are found explicitly. The proof of the theorem on the existence of analytic continuation is based on the introduction of α-representation for dual Feynman amplitudes. In proving, the so-called ''trees formula'' and ''trees-with-cycles formula'' are established that are dual by formulation to the trees and 2-trees formulae for usual Feynman amplitudes. (Auth.)

  2. Amplitude-Integrated EEG in the Newborn

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2008-11-01

    Full Text Available Th value of amplitude-integrated electroencephalography (aEEG in the newborn is explored by researchers at Washington University, St Louis; Wilhelmina Children’s Hospital, Utrecht, Netherlands; and Uppsala University Hospital, Sweden.

  3. Effective string theory and QCD scattering amplitudes

    International Nuclear Information System (INIS)

    Makeenko, Yuri

    2011-01-01

    QCD string is formed at distances larger than the confinement scale and can be described by the Polchinski-Strominger effective string theory with a nonpolynomial action, which has nevertheless a well-defined semiclassical expansion around a long-string ground state. We utilize modern ideas about the Wilson-loop/scattering-amplitude duality to calculate scattering amplitudes and show that the expansion parameter in the effective string theory is small in the Regge kinematical regime. For the amplitudes we obtain the Regge behavior with a linear trajectory of the intercept (d-2)/24 in d dimensions, which is computed semiclassically as a momentum-space Luescher term, and discuss an application to meson scattering amplitudes in QCD.

  4. Scattering Amplitudes via Algebraic Geometry Methods

    CERN Document Server

    Søgaard, Mads; Damgaard, Poul Henrik

    This thesis describes recent progress in the understanding of the mathematical structure of scattering amplitudes in quantum field theory. The primary purpose is to develop an enhanced analytic framework for computing multiloop scattering amplitudes in generic gauge theories including QCD without Feynman diagrams. The study of multiloop scattering amplitudes is crucial for the new era of precision phenomenology at the Large Hadron Collider (LHC) at CERN. Loop-level scattering amplitudes can be reduced to a basis of linearly independent integrals whose coefficients are extracted from generalized unitarity cuts. We take advantage of principles from algebraic geometry in order to extend the notion of maximal cuts to a large class of two- and three-loop integrals. This allows us to derive unique and surprisingly compact formulae for the coefficients of the basis integrals. Our results are expressed in terms of certain linear combinations of multivariate residues and elliptic integrals computed from products of ...

  5. Correlative BOLD MR imaging of stages of synovitis in a rabbit model of antigen-induced arthritis

    International Nuclear Information System (INIS)

    Doria, Andrea S.; Crawley, Adrian; Gahunia, Harpal; Rayner, Tammy; Tassos, Vivian; Zhong, Anguo; Moineddin, Rahim; Pritzker, Kenneth; Mendes, Maria; Jong, Roland; Salter, Robert B.

    2012-01-01

    Because of the ability of blood-oxygen-level-dependent (BOLD) MRI to assess blood oxygenation changes within the microvasculature, this technique holds potential for evaluating early perisynovial changes in inflammatory arthritis. To evaluate the feasibility of BOLD MRI to detect interval perisynovial changes in knees of rabbits with inflammatory arthritis. Rabbit knees were injected with albumin (n=9) or saline (n=6) intra-articularly, or were not injected (control knees, n=9). Except for two rabbits (albumin-injected, n=2 knees; saline-injected, n=2 knees) that unexpectedly died on days 7 and 21 of the experiment, respectively, all other animals were scanned with BOLD MRI on days 0, 1, 7, 14, 21 and 28 after induction of arthritis. T2*-weighted gradient-echo MRI was performed during alternate 30 s of normoxia/hyperoxia. BOLD MRI measurements were compared with clinical, laboratory and histological markers. Percentage of activated voxels was significantly greater in albumin-injected knees than in contralateral saline-injected knees (P=0.04). For albumin-injected knees (P < 0.05) and among different categories of knees (P=0.009), the percentage of activated BOLD voxels varied over time. A quadratic curve for on-and-off BOLD difference was delineated for albumin- and saline-injected knees over time (albumin-injected, P=0.047; saline-injected, P=0.009). A trend toward a significant difference in synovial histological scores between albumin-injected and saline-injected knees was noted only for acute scores (P=0.07). As a proof of concept, BOLD MRI can depict perisynovial changes during progression of experimental arthritis. (orig.)

  6. Correlative BOLD MR imaging of stages of synovitis in a rabbit model of antigen-induced arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Doria, Andrea S. [Hospital for Sick Children, Department of Diagnostic Imaging, Toronto (Canada); University of Toronto, Department of Medical Imaging, Toronto (Canada); Crawley, Adrian [University of Toronto, Department of Medical Imaging, Toronto (Canada); Toronto Western Hospital, Department of Medical Imaging, Toronto (Canada); Gahunia, Harpal; Rayner, Tammy; Tassos, Vivian; Zhong, Anguo [Hospital for Sick Children, Department of Diagnostic Imaging, Toronto (Canada); Moineddin, Rahim [Family and Community Medicine, Department of Public Health, Toronto (Canada); Pritzker, Kenneth; Mendes, Maria; Jong, Roland [Mount Sinai Hospital, Department of Pathology and Laboratory Medicine, Toronto (Canada); Salter, Robert B. [Hospital for Sick Children, Department of Orthopedic Surgery, Toronto (Canada)

    2012-01-15

    Because of the ability of blood-oxygen-level-dependent (BOLD) MRI to assess blood oxygenation changes within the microvasculature, this technique holds potential for evaluating early perisynovial changes in inflammatory arthritis. To evaluate the feasibility of BOLD MRI to detect interval perisynovial changes in knees of rabbits with inflammatory arthritis. Rabbit knees were injected with albumin (n=9) or saline (n=6) intra-articularly, or were not injected (control knees, n=9). Except for two rabbits (albumin-injected, n=2 knees; saline-injected, n=2 knees) that unexpectedly died on days 7 and 21 of the experiment, respectively, all other animals were scanned with BOLD MRI on days 0, 1, 7, 14, 21 and 28 after induction of arthritis. T2*-weighted gradient-echo MRI was performed during alternate 30 s of normoxia/hyperoxia. BOLD MRI measurements were compared with clinical, laboratory and histological markers. Percentage of activated voxels was significantly greater in albumin-injected knees than in contralateral saline-injected knees (P=0.04). For albumin-injected knees (P < 0.05) and among different categories of knees (P=0.009), the percentage of activated BOLD voxels varied over time. A quadratic curve for on-and-off BOLD difference was delineated for albumin- and saline-injected knees over time (albumin-injected, P=0.047; saline-injected, P=0.009). A trend toward a significant difference in synovial histological scores between albumin-injected and saline-injected knees was noted only for acute scores (P=0.07). As a proof of concept, BOLD MRI can depict perisynovial changes during progression of experimental arthritis. (orig.)

  7. Effective gluon interactions from superstring disk amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Oprisa, D.

    2006-05-15

    In this thesis an efficient method for the calculation of the N-point tree-level string amplitudes is presented. Furthermore it is shown that the six-gluon open-superstring disk amplitude can be expressed by a basis of six triple hypergeometric functions, which encode the full {alpha}' dependence. In this connection material for obtaining the {alpha}' expansion of these functions is derived. Hereby many Euler-Zagier sums are calculated including multiple harmonic series. (HSI)

  8. Effective gluon interactions from superstring disk amplitudes

    International Nuclear Information System (INIS)

    Oprisa, D.

    2006-05-01

    In this thesis an efficient method for the calculation of the N-point tree-level string amplitudes is presented. Furthermore it is shown that the six-gluon open-superstring disk amplitude can be expressed by a basis of six triple hypergeometric functions, which encode the full α' dependence. In this connection material for obtaining the α' expansion of these functions is derived. Hereby many Euler-Zagier sums are calculated including multiple harmonic series. (HSI)

  9. Employing helicity amplitudes for resummation in SCET

    International Nuclear Information System (INIS)

    Moult, Ian; Stewart, Iain W.; Tackmann, Frank J.; Waalewijn, Wouter J.; Nikhef, Amsterdam

    2016-05-01

    Helicity amplitudes are the fundamental ingredients of many QCD calculations for multi-leg processes. We describe how these can seamlessly be combined with resummation in Soft-Collinear Effective Theory (SCET), by constructing a helicity operator basis for which the Wilson coefficients are directly given in terms of color-ordered helicity amplitudes. This basis is crossing symmetric and has simple transformation properties under discrete symmetries.

  10. The amplitude of quantum field theory

    International Nuclear Information System (INIS)

    Medvedev, B.V.; Pavlov, V.P.; Polivanov, M.K.; Sukhanov, A.D.

    1989-01-01

    General properties of the transition amplitude in axiomatic quantum field theory are discussed. Bogolyubov's axiomatic method is chosen as the variant of the theory. The axioms of this method are analyzed. In particular, the significance of the off-shell extension and of the various forms of the causality condition are examined. A complete proof is given of the existence of a single analytic function whose boundary values are the amplitudes of all channels of a process with given particle number

  11. The Cepheid bump progression and amplitude equations

    International Nuclear Information System (INIS)

    Kovacs, G.; Buchler, J.R.

    1989-01-01

    It is shown that the characteristic and systematic behavior of the low-order Fourier amplitudes and phases of hydrodynamically generated radial velocity and light curves of Cepheid model sequences is very well captured not only qualitatively but also quantitatively by the amplitude equation formalism. The 2:1 resonance between the fundamental and the second overtone plays an essential role in the behavior of the models 8 refs

  12. Dictionary-driven Ischemia Detection from Cardiac Phase-Resolved Myocardial BOLD MRI at Rest

    Science.gov (United States)

    Bevilacqua, Marco; Dharmakumar, Rohan; Tsaftaris, Sotirios A.

    2016-01-01

    Cardiac Phase-resolved Blood-Oxygen-Level Dependent (CP–BOLD) MRI provides a unique opportunity to image an ongoing ischemia at rest. However, it requires post-processing to evaluate the extent of ischemia. To address this, here we propose an unsupervised ischemia detection (UID) method which relies on the inherent spatio-temporal correlation between oxygenation and wall motion to formalize a joint learning and detection problem based on dictionary decomposition. Considering input data of a single subject, it treats ischemia as an anomaly and iteratively learns dictionaries to represent only normal observations (corresponding to myocardial territories remote to ischemia). Anomaly detection is based on a modified version of One-class Support Vector Machines (OCSVM) to regulate directly the margins by incorporating the dictionary-based representation errors. A measure of ischemic extent (IE) is estimated, reflecting the relative portion of the myocardium affected by ischemia. For visualization purposes an ischemia likelihood map is created by estimating posterior probabilities from the OCSVM outputs, thus obtaining how likely the classification is correct. UID is evaluated on synthetic data and in a 2D CP–BOLD data set from a canine experimental model emulating acute coronary syndromes. Comparing early ischemic territories identified with UID against infarct territories (after several hours of ischemia), we find that IE, as measured by UID, is highly correlated (Pearson’s r = 0.84) w.r.t. infarct size. When advances in automated registration and segmentation of CP–BOLD images and full coverage 3D acquisitions become available, we hope that this method can enable pixel-level assessment of ischemia with this truly non-invasive imaging technique. PMID:26292338

  13. Cholinergic enhancement reduces functional connectivity and BOLD variability in visual extrastriate cortex during selective attention.

    Science.gov (United States)

    Ricciardi, Emiliano; Handjaras, Giacomo; Bernardi, Giulio; Pietrini, Pietro; Furey, Maura L

    2013-01-01

    Enhancing cholinergic function improves performance on various cognitive tasks and alters neural responses in task specific brain regions. We have hypothesized that the changes in neural activity observed during increased cholinergic function reflect an increase in neural efficiency that leads to improved task performance. The current study tested this hypothesis by assessing neural efficiency based on cholinergically-mediated effects on regional brain connectivity and BOLD signal variability. Nine subjects participated in a double-blind, placebo-controlled crossover fMRI study. Following an infusion of physostigmine (1 mg/h) or placebo, echo-planar imaging (EPI) was conducted as participants performed a selective attention task. During the task, two images comprised of superimposed pictures of faces and houses were presented. Subjects were instructed periodically to shift their attention from one stimulus component to the other and to perform a matching task using hand held response buttons. A control condition included phase-scrambled images of superimposed faces and houses that were presented in the same temporal and spatial manner as the attention task; participants were instructed to perform a matching task. Cholinergic enhancement improved performance during the selective attention task, with no change during the control task. Functional connectivity analyses showed that the strength of connectivity between ventral visual processing areas and task-related occipital, parietal and prefrontal regions reduced significantly during cholinergic enhancement, exclusively during the selective attention task. Physostigmine administration also reduced BOLD signal temporal variability relative to placebo throughout temporal and occipital visual processing areas, again during the selective attention task only. Together with the observed behavioral improvement, the decreases in connectivity strength throughout task-relevant regions and BOLD variability within stimulus

  14. BOLD quantified renal pO2 is sensitive to pharmacological challenges in rats.

    Science.gov (United States)

    Thacker, Jon; Zhang, Jeff L; Franklin, Tammy; Prasad, Pottumarthi

    2017-07-01

    Blood oxygen level-dependent (BOLD) MRI has been effectively used to monitor changes in renal oxygenation. However, R2* (or T2*) is not specific to blood oxygenation and is dependent on other factors. This study investigates the use of a statistical model that takes these factors into account and maps BOLD MRI measurements to blood pO2. Spin echo and gradient echo images were obtained in six Sprague-Dawley rats and R2 and R2* maps were computed. Measurements were made at baseline, post-nitric oxide synthase inhibitor (L-NAME), and post-furosemide administration. A simulation of each region was performed to map R2' (computed as R2*-R2) to blood pO2. At baseline, blood pO2 in the outer medulla was 30.5 ± 1.2 mmHg and 51.9 ± 5.2 mmHg in the cortex, in agreement with previous invasive studies. Blood pO2 was found to decrease within the outer medulla following L-NAME (P pO2 in the cortex increased following furosemide (P pO2 is sensitive to pharmacological challenges, and baseline pO2 is comparable to literature values. Reporting pO2 instead of R2* could lead to a greater clinical impact of renal BOLD MRI and facilitate the identification of hypoxic regions. Magn Reson Med 78:297-302, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  15. Hypoxia in Prostate Cancer: Correlation of BOLD-MRI With Pimonidazole Immunohistochemistry-Initial Observations

    International Nuclear Information System (INIS)

    Hoskin, Peter J.; Carnell, Dawn M.; Taylor, N. Jane; Smith, Rowena E.; Stirling, J. James; Daley, Frances M.; Saunders, Michele I.; Bentzen, Soren M.; Collins, David J.; D'Arcy, James A.; Padhani, Anwar P.

    2007-01-01

    Purpose: To investigate the ability of blood oxygen level-dependent (BOLD) MRI to depict clinically significant prostate tumor hypoxia. Methods and Materials: Thirty-three patients with prostate carcinoma undergoing radical prostatectomy were studied preoperatively, using gradient echo sequences without and with contrast medium enhancement, to map relative tissue oxygenation according to relaxivity rates and relative blood volume (rBV). Pimonidazole was administered preoperatively, and whole-mount sections of selected tumor-bearing slices were stained for pimonidazole fixation and tumor and nontumor localization. Histologic and imaging parameters were independently mapped onto patient prostate outlines. Using 5-mm grids, 861 nontumor grid locations were compared with 237 tumor grids (with >50% tumor per location) using contingency table analysis with respect to the ability of imaging to predict pimonidazole staining. Results: Twenty patients completed the imaging and histologic protocols. Pimonidazole staining was found in 33% of nontumor and in 70% of tumor grids. The sensitivity of the MR relaxivity parameter R 2 * in depicting tumor hypoxia was high (88%), improving with the addition of low rBV information (95%) without changing specificity (36% and 29%, respectively). High R 2 * increased the positive predictive value for hypoxia by 6% (70% to 76%); conversely, low R 2 * decreased the likelihood of hypoxia being present by 26% (70% to 44%) and by 41% (71% to 30%) when combined with rBV information. Conclusion: R 2 * maps from BOLD-MRI have high sensitivity but low specificity for defining intraprostatic tumor hypoxia. This together with the negative predictive value of 70% when combined with blood volume information makes BOLD-MRI a potential noninvasive technique for mapping prostatic tumor hypoxia

  16. Wavelet entropy of BOLD time series: An application to Rolandic epilepsy.

    Science.gov (United States)

    Gupta, Lalit; Jansen, Jacobus F A; Hofman, Paul A M; Besseling, René M H; de Louw, Anton J A; Aldenkamp, Albert P; Backes, Walter H

    2017-12-01

    To assess the wavelet entropy for the characterization of intrinsic aberrant temporal irregularities in the time series of resting-state blood-oxygen-level-dependent (BOLD) signal fluctuations. Further, to evaluate the temporal irregularities (disorder/order) on a voxel-by-voxel basis in the brains of children with Rolandic epilepsy. The BOLD time series was decomposed using the discrete wavelet transform and the wavelet entropy was calculated. Using a model time series consisting of multiple harmonics and nonstationary components, the wavelet entropy was compared with Shannon and spectral (Fourier-based) entropy. As an application, the wavelet entropy in 22 children with Rolandic epilepsy was compared to 22 age-matched healthy controls. The images were obtained by performing resting-state functional magnetic resonance imaging (fMRI) using a 3T system, an 8-element receive-only head coil, and an echo planar imaging pulse sequence ( T2*-weighted). The wavelet entropy was also compared to spectral entropy, regional homogeneity, and Shannon entropy. Wavelet entropy was found to identify the nonstationary components of the model time series. In Rolandic epilepsy patients, a significantly elevated wavelet entropy was observed relative to controls for the whole cerebrum (P = 0.03). Spectral entropy (P = 0.41), regional homogeneity (P = 0.52), and Shannon entropy (P = 0.32) did not reveal significant differences. The wavelet entropy measure appeared more sensitive to detect abnormalities in cerebral fluctuations represented by nonstationary effects in the BOLD time series than more conventional measures. This effect was observed in the model time series as well as in Rolandic epilepsy. These observations suggest that the brains of children with Rolandic epilepsy exhibit stronger nonstationary temporal signal fluctuations than controls. 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1728-1737. © 2017 International Society for Magnetic

  17. Moment-to-Moment BOLD Signal Variability Reflects Regional Changes in Neural Flexibility across the Lifespan.

    Science.gov (United States)

    Nomi, Jason S; Bolt, Taylor S; Ezie, C E Chiemeka; Uddin, Lucina Q; Heller, Aaron S

    2017-05-31

    Variability of neuronal responses is thought to underlie flexible and optimal brain function. Because previous work investigating BOLD signal variability has been conducted within task-based fMRI contexts on adults and older individuals, very little is currently known regarding regional changes in spontaneous BOLD signal variability in the human brain across the lifespan. The current study used resting-state fMRI data from a large sample of male and female human participants covering a wide age range (6-85 years) across two different fMRI acquisition parameters (TR = 0.645 and 1.4 s). Variability in brain regions including a key node of the salience network (anterior insula) increased linearly across the lifespan across datasets. In contrast, variability in most other large-scale networks decreased linearly over the lifespan. These results demonstrate unique lifespan trajectories of BOLD variability related to specific regions of the brain and add to a growing literature demonstrating the importance of identifying normative trajectories of functional brain maturation. SIGNIFICANCE STATEMENT Although brain signal variability has traditionally been considered a source of unwanted noise, recent work demonstrates that variability in brain signals during task performance is related to brain maturation in old age as well as individual differences in behavioral performance. The current results demonstrate that intrinsic fluctuations in resting-state variability exhibit unique maturation trajectories in specific brain regions and systems, particularly those supporting salience detection. These results have implications for investigations of brain development and aging, as well as interpretations of brain function underlying behavioral changes across the lifespan. Copyright © 2017 the authors 0270-6474/17/375539-10$15.00/0.

  18. Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease

    Science.gov (United States)

    Price, J.L.; Yan, Z.; Morris, J.C.; Sheline, Y.I.

    2011-01-01

    Objective: Clinicopathologic phenotypes of dementia with Lewy bodies (DLB) and Alzheimer disease (AD) often overlap, making discrimination difficult. We performed resting state blood oxygen level–dependent (BOLD) functional connectivity MRI (fcMRI) to determine whether there were differences between AD and DLB. Methods: Participants (n = 88) enrolled in a longitudinal study of memory and aging underwent 3-T fcMRI. Clinical diagnoses of probable DLB (n = 15) were made according to published criteria. Cognitively normal control participants (n = 38) were selected for the absence of cerebral amyloid burden as imaged with Pittsburgh compound B (PiB). Probable AD cases (n = 35) met published criteria and had appreciable amyloid deposits with PiB imaging. Functional images were collected using a gradient spin-echo sequence sensitive to BOLD contrast (T2* weighting). Correlation maps selected a seed region in the combined bilateral precuneus. Results: Participants with DLB had a functional connectivity pattern for the precuneus seed region that was distinct from AD; both the DLB and AD groups had functional connectivity patterns that differed from the cognitively normal group. In the DLB group, we found increased connectivity between the precuneus and regions in the dorsal attention network and the putamen. In contrast, we found decreased connectivity between the precuneus and other task-negative default regions and visual cortices. There was also a reversal of connectivity in the right hippocampus. Conclusions: Changes in functional connectivity in DLB indicate patterns of activation that are distinct from those seen in AD and may improve discrimination of DLB from AD and cognitively normal individuals. Since patterns of connectivity differ between AD and DLB groups, measurements of BOLD functional connectivity can shed further light on neuroanatomic connections that distinguish DLB from AD. PMID:21525427

  19. Measurement of amplitude fluctuations in a rapid response photomultiplier; Mesure des fluctuations d'amplitude d'un photo multiplicateur a reponse rapide

    Energy Technology Data Exchange (ETDEWEB)

    Raimbault, P [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    In order to measure amplitude fluctuations in a rapid response photomultiplier, two independent random variables are introduced which determine the shape of the anode pulse. The energy of each pulse, which depends directly on the gain and the variance, is the first variable; amplitude fluctuations, functions of the first variable, depend as well on the pulse width which in turn constitutes the second variable. The results obtained on the variations of the maximum impulse, using a steep-edged pulse broadening circuit, and those obtained on the statistical variations of the gain, are compared to show that the variance relative to the maximum amplitude of the signal is greater than that of the gain. Within the limits of these fluctuations are shown the contribution of the secondary emission coefficient of the first dynode, and that of the mean secondary emission coefficient of the multiplier. (author) [French] Pour etudier les fluctuations d'amplitude d'un photomultiplicateur a reponse rapide, on introduit deux variables aleatoires independantes qui determinent la forme de l'impulsion anodique. L'energie de chaque impulsion, directement fonction du gain et de sa variance, est la premiere variable; les fluctuations d'amplitude, fonctions de la premiere variable, dependent egalement de la largeur de l'impulsion qui, elle, constitue la deuxieme variable. Les resultats obtenus sur les variations de l'amplitude maximale, a l'aide d'un circuit elargisseur d'impulsions a front raide, et les resultats des variations statistiques du gain sont compares pour mettre en evidence le fait que la variance relative a l'amplitude maximale du signal est plus grande que celle du gain. Dans la mesure de ces fluctuations, sont mises en evidence la contribution du coefficient d'emission secondaire de la premiere dynode et celle du coefficient d'emission secondaire moyen du multiplicateur. (auteur)

  20. BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis, Version III

    International Nuclear Information System (INIS)

    Vondy, D.R.; Fowler, T.B.; Cunningham, G.W. III.

    1981-06-01

    This report is a condensed documentation for VERSION III of the BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis. An experienced analyst should be able to use this system routinely for solving problems by referring to this document. Individual reports must be referenced for details. This report covers basic input instructions and describes recent extensions to the modules as well as to the interface data file specifications. Some application considerations are discussed and an elaborate sample problem is used as an instruction aid. Instructions for creating the system on IBM computers are also given

  1. Bold Ideas for the 4th H in 4-H: Teen Identified Concerns and Actions

    Directory of Open Access Journals (Sweden)

    Virginia Brown

    2015-03-01

    Full Text Available This article summarizes a literature review; teen-identified health concerns and issues; and teen bold ideas for actions. Findings from the National 4-H Council and Molina Healthcare Teens Take on Health initiative are provided and implications for 4-H programming tied to the new Cooperative Extension National Framework for Health and Wellness are addressed. The article is intended as background for Extension educators, volunteers and administrators as they review the 4-H Healthy Living Mission Mandate, learn what mattered to teens and consider how to incorporate the findings into state and local 4-H youth development programming.

  2. Distinct BOLD Activation Profiles Following Central and Peripheral Oxytocin Administration in Awake Rats.

    Science.gov (United States)

    Ferris, Craig F; Yee, Jason R; Kenkel, William M; Dumais, Kelly Marie; Moore, Kelsey; Veenema, Alexa H; Kulkarni, Praveen; Perkybile, Allison M; Carter, C Sue

    2015-01-01

    A growing body of literature has suggested that intranasal oxytocin (OT) or other systemic routes of administration can alter prosocial behavior, presumably by directly activating OT sensitive neural circuits in the brain. Yet there is no clear evidence that OT given peripherally can cross the blood-brain barrier at levels sufficient to engage the OT receptor. To address this issue we examined changes in blood oxygen level-dependent (BOLD) signal intensity in response to peripheral OT injections (0.1, 0.5, or 2.5 mg/kg) during functional magnetic resonance imaging (fMRI) in awake rats imaged at 7.0 T. These data were compared to OT (1 μg/5 μl) given directly to the brain via the lateral cerebroventricle. Using a 3D annotated MRI atlas of the rat brain segmented into 171 brain areas and computational analysis, we reconstructed the distributed integrated neural circuits identified with BOLD fMRI following central and peripheral OT. Both routes of administration caused significant changes in BOLD signal within the first 10 min of administration. As expected, central OT activated a majority of brain areas known to express a high density of OT receptors, e.g., lateral septum, subiculum, shell of the accumbens, bed nucleus of the stria terminalis. This profile of activation was not matched by peripheral OT. The change in BOLD signal to peripheral OT did not show any discernible dose-response. Interestingly, peripheral OT affected all subdivisions of the olfactory bulb, in addition to the cerebellum and several brainstem areas relevant to the autonomic nervous system, including the solitary tract nucleus. The results from this imaging study do not support a direct central action of peripheral OT on the brain. Instead, the patterns of brain activity suggest that peripheral OT may interact at the level of the olfactory bulb and through sensory afferents from the autonomic nervous system to influence brain activity.

  3. BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis, Version III

    Energy Technology Data Exchange (ETDEWEB)

    Vondy, D.R.; Fowler, T.B.; Cunningham, G.W. III.

    1981-06-01

    This report is a condensed documentation for VERSION III of the BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis. An experienced analyst should be able to use this system routinely for solving problems by referring to this document. Individual reports must be referenced for details. This report covers basic input instructions and describes recent extensions to the modules as well as to the interface data file specifications. Some application considerations are discussed and an elaborate sample problem is used as an instruction aid. Instructions for creating the system on IBM computers are also given.

  4. Working memory in volunteers and schizophrenics using BOLD fMRI

    International Nuclear Information System (INIS)

    Giesel, F.L.; Hohmann, N.; Seidl, U.; Kress, K.R.; Schoenknecht, P.; Schroeder, J.; Kauczor, H.-U.; Essig, M.

    2005-01-01

    Functional magnetic resonance imaging uses the blood oxygen level-dependent effect (BOLD MRI) for noninvasive display of cerebral correlatives of cognitive function. The importance for the understanding of physiological and pathological processes is demonstrated by investigations of working memory in schizophrenics and healthy controls. Working memory is involved in processing rather than storage of information and therefore is linked to complex processes such as learning and problem solving. In schizophrenic psychosis, these functions are clearly restricted. Training effects in the working memory task follow an inverse U-shape function, suggesting that cerebral activation reaches a peak before economics of the brain find a more efficient method and activation decreases. (orig.) [de

  5. Scattering amplitudes in open superstring theory

    Energy Technology Data Exchange (ETDEWEB)

    Schlotterer, Oliver

    2011-07-15

    The present thesis deals with the theme field of the scattering amplitudes in theories of open superstrings. Especially two different formalisms for the handling of superstrings are introduced and applied for the calaculation of tree-level amplitudes - the Ramond- Neveu-Schwarz (RNS) and the Pure-Spinor (PS) formalism. The RNS approach is proved as flexible in order to describe compactification of the initially ten flat space-time dimensions to four dimensions. We solve the technical problems, which result from the interacting basing world-sheet theory with conformal symmetry. This is used to calculate phenomenologically relevant scattering amplitudes of gluons and quarks as well as production rates of massive harmonic vibrations, which were already identified as virtual exchange particles on the massless level. In the case of a low string mass scale in the range of some Tev the string-specific signatures in parton collisions can be observed in the near future in the LHC experiment at CERN and indicated as first experimental proof of the string theory. THose string effects occur universally for a wide class of string ground states respectively internal geometries and represent an elegant way to avoid the so-called landscape problem of the string theory. A further theme complex in this thesis is based on the PS formalism, which allows a manifestly supersymmetric treatment of scattering amplitudes in ten space-time dimension with sixteen supercharges. We introduce a family of superfields, which occur in massless amplitudes of the open string and can be naturally identified with diagrams of three-valued knots. Thereby we reach not only a compact superspace representation of the n-point field-theory amplitude but can also write the complete superstring n-point amplitude as minimal linear combination of partial amplitudes of the field theory as well as hypergeometric functions. The latter carry the string effects and are analyzed from different perspectives, above all

  6. Scattering amplitudes in open superstring theory

    International Nuclear Information System (INIS)

    Schlotterer, Oliver

    2011-01-01

    The present thesis deals with the theme field of the scattering amplitudes in theories of open superstrings. Especially two different formalisms for the handling of superstrings are introduced and applied for the calaculation of tree-level amplitudes - the Ramond- Neveu-Schwarz (RNS) and the Pure-Spinor (PS) formalism. The RNS approach is proved as flexible in order to describe compactification of the initially ten flat space-time dimensions to four dimensions. We solve the technical problems, which result from the interacting basing world-sheet theory with conformal symmetry. This is used to calculate phenomenologically relevant scattering amplitudes of gluons and quarks as well as production rates of massive harmonic vibrations, which were already identified as virtual exchange particles on the massless level. In the case of a low string mass scale in the range of some Tev the string-specific signatures in parton collisions can be observed in the near future in the LHC experiment at CERN and indicated as first experimental proof of the string theory. THose string effects occur universally for a wide class of string ground states respectively internal geometries and represent an elegant way to avoid the so-called landscape problem of the string theory. A further theme complex in this thesis is based on the PS formalism, which allows a manifestly supersymmetric treatment of scattering amplitudes in ten space-time dimension with sixteen supercharges. We introduce a family of superfields, which occur in massless amplitudes of the open string and can be naturally identified with diagrams of three-valued knots. Thereby we reach not only a compact superspace representation of the n-point field-theory amplitude but can also write the complete superstring n-point amplitude as minimal linear combination of partial amplitudes of the field theory as well as hypergeometric functions. The latter carry the string effects and are analyzed from different perspectives, above all

  7. Direct amplitude detuning measurement with ac dipole

    Directory of Open Access Journals (Sweden)

    S. White

    2013-07-01

    Full Text Available In circular machines, nonlinear dynamics can impact parameters such as beam lifetime and could result in limitations on the performance reach of the accelerator. Assessing and understanding these effects in experiments is essential to confirm the accuracy of the magnetic model and improve the machine performance. A direct measurement of the machine nonlinearities can be obtained by characterizing the dependency of the tune as a function of the amplitude of oscillations (usually defined as amplitude detuning. The conventional technique is to excite the beam to large amplitudes with a single kick and derive the tune from turn-by-turn data acquired with beam position monitors. Although this provides a very precise tune measurement it has the significant disadvantage of being destructive. An alternative, nondestructive way of exciting large amplitude oscillations is to use an ac dipole. The perturbation Hamiltonian in the presence of an ac dipole excitation shows a distinct behavior compared to the free oscillations which should be correctly taken into account in the interpretation of experimental data. The use of an ac dipole for direct amplitude detuning measurement requires careful data processing allowing one to observe the natural tune of the machine; the feasibility of such a measurement is demonstrated using experimental data from the Large Hadron Collider. An experimental proof of the theoretical derivations based on measurements performed at injection energy is provided as well as an application of this technique at top energy using a large number of excitations on the same beam.

  8. Color-Kinematics Duality for QCD Amplitudes

    CERN Document Server

    Johansson, Henrik

    2016-01-01

    We show that color-kinematics duality is present in tree-level amplitudes of quantum chromodynamics with massive flavored quarks. Starting with the color structure of QCD, we work out a new color decomposition for n-point tree amplitudes in a reduced basis of primitive amplitudes. These primitives, with k quark-antiquark pairs and (n-2k) gluons, are taken in the (n-2)!/k! Melia basis, and are independent under the color-algebra Kleiss-Kuijf relations. This generalizes the color decomposition of Del Duca, Dixon, and Maltoni to an arbitrary number of quarks. The color coefficients in the new decomposition are given by compact expressions valid for arbitrary gauge group and representation. Considering the kinematic structure, we show through explicit calculations that color-kinematics duality holds for amplitudes with general configurations of gluons and massive quarks. The new (massive) amplitude relations that follow from the duality can be mapped to a well-defined subset of the familiar BCJ relations for gluo...

  9. Evaluating the impact of spatio-temporal smoothness constraints on the BOLD hemodynamic response function estimation: an analysis based on Tikhonov regularization

    International Nuclear Information System (INIS)

    Casanova, R; Yang, L; Hairston, W D; Laurienti, P J; Maldjian, J A

    2009-01-01

    Recently we have proposed the use of Tikhonov regularization with temporal smoothness constraints to estimate the BOLD fMRI hemodynamic response function (HRF). The temporal smoothness constraint was imposed on the estimates by using second derivative information while the regularization parameter was selected based on the generalized cross-validation function (GCV). Using one-dimensional simulations, we previously found this method to produce reliable estimates of the HRF time course, especially its time to peak (TTP), being at the same time fast and robust to over-sampling in the HRF estimation. Here, we extend the method to include simultaneous temporal and spatial smoothness constraints. This method does not need Gaussian smoothing as a pre-processing step as usually done in fMRI data analysis. We carried out two-dimensional simulations to compare the two methods: Tikhonov regularization with temporal (Tik-GCV-T) and spatio-temporal (Tik-GCV-ST) smoothness constraints on the estimated HRF. We focus our attention on quantifying the influence of the Gaussian data smoothing and the presence of edges on the performance of these techniques. Our results suggest that the spatial smoothing introduced by regularization is less severe than that produced by Gaussian smoothing. This allows more accurate estimates of the response amplitudes while producing similar estimates of the TTP. We illustrate these ideas using real data. (note)

  10. Distinction between Neural and Vascular BOLD Oscillations and Intertwined Heart Rate Oscillations at 0.1 Hz in the Resting State and during Movement.

    Directory of Open Access Journals (Sweden)

    Gert Pfurtscheller

    Full Text Available In the resting state, blood oxygen level-dependent (BOLD oscillations with a frequency of about 0.1 Hz are conspicuous. Whether their origin is neural or vascular is not yet fully understood. Furthermore, it is not clear whether these BOLD oscillations interact with slow oscillations in heart rate (HR. To address these two questions, we estimated phase-locking (PL values between precentral gyrus (PCG and insula in 25 scanner-naïve individuals during rest and stimulus-paced finger movements in both hemispheres. PL was quantified in terms of time delay and duration in the frequency band 0.07 to 0.13 Hz. Results revealed both positive and negative time delays. Positive time delays characterize neural BOLD oscillations leading in the PCG, whereas negative time delays represent vascular BOLD oscillations leading in the insula. About 50% of the participants revealed positive time delays distinctive for neural BOLD oscillations, either with short or long unilateral or bilateral phase-locking episodes. An expected preponderance of neural BOLD oscillations was found in the left hemisphere during right-handed movement and unexpectedly in the right hemisphere during rest. Only neural BOLD oscillations were significantly associated with heart rate variability (HRV in the 0.1-Hz range in the first resting state. It is well known that participating in magnetic resonance imaging (MRI studies may be frightening and cause anxiety. In this respect it is important to note that the most significant hemispheric asymmetry (p<0.002 with a right-sided dominance of neural BOLD and a left-sided dominance of vascular BOLD oscillations was found in the first resting session in the scanner-naïve individuals. Whether the enhanced left-sided perfusion (dominance of vascular BOLD or the right-sided dominance of neural BOLD is related to the increased level of anxiety, attention or stress needs further research.

  11. High energy hadron spin-flip amplitude

    International Nuclear Information System (INIS)

    Selyugin, O.V.

    2016-01-01

    The high-energy part of the hadron spin-flip amplitude is examined in the framework of the new high-energy general structure (HEGS) model of the elastic hadron scattering at high energies. The different forms of the hadron spin-flip amplitude are compared in the impact parameter representation. It is shown that the existing experimental data of the proton-proton and proton-antiproton elastic scattering at high energy in the region of the diffraction minimum and at large momentum transfer give support in the presence of the energy-independent part of the hadron spin-flip amplitude with the momentum dependence proposed in the works by Galynskii-Kuraev. [ru

  12. Scaling of saturation amplitudes in baroclinic instability

    International Nuclear Information System (INIS)

    Shepherd, T.G.

    1994-01-01

    By using finite-amplitude conservation laws for pseudomomentum and pseudoenergy, rigorous upper bounds have been derived on the saturation amplitudes in baroclinic instability for layered and continuously-stratified quasi-geostrophic models. Bounds have been obtained for both the eddy energy and the eddy potential enstrophy. The bounds apply to conservative (inviscid, unforced) flow, as well as to forced-dissipative flow when the dissipation is proportional to the potential vorticity. This approach provides an efficient way of extracting an analytical estimate of the dynamical scalings of the saturation amplitudes in terms of crucial non-dimensional parameters. A possible use is in constructing eddy parameterization schemes for zonally-averaged climate models. The scaling dependences are summarized, and compared with those derived from weakly-nonlinear theory and from baroclinic-adjustment estimates

  13. Analytic representations of Yang–Mills amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Bjerrum-Bohr, N.E.J. [Niels Bohr International Academy and Discovery Center, The Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, DK-2100 Copenhagen Ø (Denmark); Bourjaily, Jacob L., E-mail: bourjaily@nbi.ku.dk [Niels Bohr International Academy and Discovery Center, The Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, DK-2100 Copenhagen Ø (Denmark); Damgaard, Poul H. [Niels Bohr International Academy and Discovery Center, The Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, DK-2100 Copenhagen Ø (Denmark); Feng, Bo [Zhejiang Institute of Modern Physics, Zhejiang University, Hangzhou City, 310027 (China)

    2016-12-15

    Scattering amplitudes in Yang–Mills theory can be represented in the formalism of Cachazo, He and Yuan (CHY) as integrals over an auxiliary projective space—fully localized on the support of the scattering equations. Because solving the scattering equations is difficult and summing over the solutions algebraically complex, a method of directly integrating the terms that appear in this representation has long been sought. We solve this important open problem by first rewriting the terms in a manifestly Möbius-invariant form and then using monodromy relations (inspired by analogy to string theory) to decompose terms into those for which combinatorial rules of integration are known. The result is the foundations of a systematic procedure to obtain analytic, covariant forms of Yang–Mills tree-amplitudes for any number of external legs and in any number of dimensions. As examples, we provide compact analytic expressions for amplitudes involving up to six gluons of arbitrary helicities.

  14. Nonlinear (super)symmetries and amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Kallosh, Renata [Physics Department, Stanford University,382 Via Pueblo Mall, Stanford, CA 94305-4060 (United States)

    2017-03-07

    There is an increasing interest in nonlinear supersymmetries in cosmological model building. Independently, elegant expressions for the all-tree amplitudes in models with nonlinear symmetries, like D3 brane Dirac-Born-Infeld-Volkov-Akulov theory, were recently discovered. Using the generalized background field method we show how, in general, nonlinear symmetries of the action, bosonic and fermionic, constrain amplitudes beyond soft limits. The same identities control, for example, bosonic E{sub 7(7)} scalar sector symmetries as well as the fermionic goldstino symmetries. We present a universal derivation of the vanishing amplitudes in the single (bosonic or fermionic) soft limit. We explain why, universally, the double-soft limit probes the coset space algebra. We also provide identities describing the multiple-soft limit. We discuss loop corrections to N≥5 supergravity, to the D3 brane, and the UV completion of constrained multiplets in string theory.

  15. Scattering Amplitudes and Worldsheet Models of QFTs

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    I will describe recent progress on the study of scattering amplitudes via ambitwistor strings and the scattering equations. Ambitwistor strings are worldsheet models of quantum field theories, inspired by string theory. They naturally lead to a representation of amplitudes based on the scattering equations. While worldsheet models and related ideas have had a wide-ranging impact on the modern study of amplitudes, their direct application at loop level is a very recent success. I will show how a major difficulty in the loop-level story, the technicalities of higher-genus Riemann surfaces, can be avoided by turning the higher-genus surface into a nodal Riemann sphere, with the nodes representing the loop momenta. I will present new formulas for the one-loop integrands of gauge theory and gravity, with or without supersymmetry, and also some two-loop results.

  16. Relativistic amplitudes in terms of wave functions

    International Nuclear Information System (INIS)

    Karmanov, V.A.

    1978-01-01

    In the framework of the invariant diagram technique which arises at the formulation of the fueld theory on the light front the question about conditions at which the relativistic amplitudes may be expressed through the wave functions is investigated. The amplitudes obtained depend on four-vector ω, determining the light front surface. The way is shown to find such values of the four-vector ω, at which the contribution of diagrams not expressed through wave functions is minimal. The investigation carried out is equivalent to the study of the dependence of amplitudes of the old-fashioned perturbation theory in the in the infinite momentum frame on direction of the infinite momentum

  17. Multiphoton amplitude in a constant background field

    Science.gov (United States)

    Ahmad, Aftab; Ahmadiniaz, Naser; Corradini, Olindo; Kim, Sang Pyo; Schubert, Christian

    2018-01-01

    In this contribution, we present our recent compact master formulas for the multiphoton amplitudes of a scalar propagator in a constant background field using the worldline fomulation of quantum field theory. The constant field has been included nonperturbatively, which is crucial for strong external fields. A possible application is the scattering of photons by electrons in a strong magnetic field, a process that has been a subject of great interest since the discovery of astrophysical objects like radio pulsars, which provide evidence that magnetic fields of the order of 1012G are present in nature. The presence of a strong external field leads to a strong deviation from the classical scattering amplitudes. We explicitly work out the Compton scattering amplitude in a magnetic field, which is a process of potential relevance for astrophysics. Our final result is compact and suitable for numerical integration.

  18. A Big Five facet analysis of sub-clinical narcissism: understanding boldness in terms of well-known personality traits.

    Science.gov (United States)

    Furnham, Adrian; Crump, John

    2014-08-01

    This study aimed to examine a Big Five 'bright-side' analysis of a sub-clinical personality disorder, i.e. narcissism. A total of 6957 British adults completed the NEO-PI-R, which measures the Big Five Personality factors at the domain and the facet level, as well as the Hogan Development Survey (HDS), which has a measure of Narcissism called Bold as one of its dysfunctional interpersonal tendencies. Correlation and regression results confirmed many of the associations between the Big Five domains and facets (NEO-PI-R) and sub-clinical narcissism. The Bold (Narcissism) scale from the HDS was the criterion variable in all analyses. Bold individuals are disagreeable extraverts with very low scores on facet Modesty but moderately high scores on Assertiveness, Competence and Achievement Striving. The study confirmed work using different population groups and different measures. Copyright © 2014 John Wiley & Sons, Ltd.

  19. Changes in BOLD and ADC weighted imaging in acute hypoxia during sea-level and altitude adapted states

    DEFF Research Database (Denmark)

    Rostrup, Egill; Larsson, Henrik B.W.; Born, Alfred P.

    2005-01-01

    possible structural changes as measured by diffusion weighted imaging. Eleven healthy sea-level residents were studied after 5 weeks of adaptation to high altitude conditions at Chacaltaya, Bolivia (5260 m). The subjects were studied immediately after return to sea-level in hypoxic and normoxic conditions...... was slightly elevated in high altitude as compared to sea-level adaptation. It is concluded that hypoxia significantly diminishes the BOLD response, and the mechanisms underlying this finding are discussed. Furthermore, altitude adaptation may influence both the magnitude of the activation-related response......, and the examinations repeated 6 months later after re-adaptation to sea-level conditions. The BOLD response, measured at 1.5 T, was severely reduced during acute hypoxia both in the altitude and sea-level adapted states (50% reduction during an average S(a)O(2) of 75%). On average, the BOLD response magnitude was 23...

  20. Effect of hypoxia on BOLD fMRI response and total cerebral blood flow in migraine with aura patients

    DEFF Research Database (Denmark)

    Arngrim, Nanna; Hougaard, Anders; Schytz, Henrik W

    2018-01-01

    was measured in the visual cortex ROIs V1-V5. Total cerebral blood flow (CBF) was calculated by measuring the blood velocity in the internal carotid arteries and the basilar artery using phase-contrast mapping (PCM) MRI. Hypoxia induced a greater decrease in BOLD response to visual stimulation in V1-V4 in MA......Experimentally induced hypoxia triggers migraine and aura attacks in patients suffering from migraine with aura (MA). We investigated the blood oxygenation level-dependent (BOLD) signal response to visual stimulation during hypoxia in MA patients and healthy volunteers. In a randomized double......-blind crossover study design, 15 MA patients were allocated to 180 min of normobaric poikilocapnic hypoxia (capillary oxygen saturation 70-75%) or sham (normoxia) on two separate days and 14 healthy volunteers were exposed to hypoxia. The BOLD functional MRI (fMRI) signal response to visual stimulation...

  1. Comparison of diffusion-weighted fMRI and BOLD fMRI responses in a verbal working memory task

    International Nuclear Information System (INIS)

    Aso, Toshihiko; Urayama, Shin-ichi; Fukuyama, Hidenao; Le Bihan, Denis

    2013-01-01

    Diffusion-weighted functional MRI (DfMRI) has been reported to have a different response pattern in the visual cortex than that of BOLD-fMRI. Especially, the DfMRI signal shows a constantly faster response at both onset and offset of the stimulus, suggesting that the DfMRI signal might be more directly linked to neuronal events than the hemodynamic response. However, because the DfMRI response also contains a residual sensitivity to BOLD this hypothesis has been challenged. Using a verbal working memory task we show that the DfMRI time-course features are preserved outside visual cortices, but also less liable to between-subject/between-regional variation than the BOLD response. The overall findings not only support the feasibility of DfMRI as an approach for functional brain imaging, but also strengthen the uniqueness of the DfMRI signal origin. (authors)

  2. Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia

    Directory of Open Access Journals (Sweden)

    Hironori Kuga, M.D.

    2016-10-01

    We acquired BOLD responses elicited by click trains of 20, 30, 40 and 80-Hz frequencies from 15 patients with acute episode schizophrenia (AESZ, 14 symptom-severity-matched patients with non-acute episode schizophrenia (NASZ, and 24 healthy controls (HC, assessed via a standard general linear-model-based analysis. The AESZ group showed significantly increased ASSR-BOLD signals to 80-Hz stimuli in the left auditory cortex compared with the HC and NASZ groups. In addition, enhanced 80-Hz ASSR-BOLD signals were associated with more severe auditory hallucination experiences in AESZ participants. The present results indicate that neural over activation occurs during 80-Hz auditory stimulation of the left auditory cortex in individuals with acute state schizophrenia. Given the possible association between abnormal gamma activity and increased glutamate levels, our data may reflect glutamate toxicity in the auditory cortex in the acute state of schizophrenia, which might lead to progressive changes in the left transverse temporal gyrus.

  3. Amplitude-modulated fiber-ring laser

    DEFF Research Database (Denmark)

    Caputo, J. G.; Clausen, Carl A. Balslev; Sørensen, Mads Peter

    2000-01-01

    Soliton pulses generated by a fiber-ring laser are investigated by numerical simulation and perturbation methods. The mathematical modeling is based on the nonlinear Schrödinger equation with perturbative terms. We show that active mode locking with an amplitude modulator leads to a self......-starting of stable solitonic pulses from small random noise, provided the modulation depth is small. The perturbative analysis leads to a nonlinear coupled return map for the amplitude, phase, and position of the soliton pulses circulating in the fiber-ring laser. We established the validity of this approach...

  4. Amplitude Models for Discrimination and Yield Estimation

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, William Scott [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-01

    This seminar presentation describes amplitude models and yield estimations that look at the data in order to inform legislation. The following points were brought forth in the summary: global models that will predict three-component amplitudes (R-T-Z) were produced; Q models match regional geology; corrected source spectra can be used for discrimination and yield estimation; three-component data increase coverage and reduce scatter in source spectral estimates; three-component efforts must include distance-dependent effects; a community effort on instrument calibration is needed.

  5. Singularity Structure of Maximally Supersymmetric Scattering Amplitudes

    DEFF Research Database (Denmark)

    Arkani-Hamed, Nima; Bourjaily, Jacob L.; Cachazo, Freddy

    2014-01-01

    We present evidence that loop amplitudes in maximally supersymmetric (N=4) Yang-Mills theory (SYM) beyond the planar limit share some of the remarkable structures of the planar theory. In particular, we show that through two loops, the four-particle amplitude in full N=4 SYM has only logarithmic ...... singularities and is free of any poles at infinity—properties closely related to uniform transcendentality and the UV finiteness of the theory. We also briefly comment on implications for maximal (N=8) supergravity theory (SUGRA)....

  6. Amplitude modulation detection with concurrent frequency modulation.

    Science.gov (United States)

    Nagaraj, Naveen K

    2016-09-01

    Human speech consists of concomitant temporal modulations in amplitude and frequency that are crucial for speech perception. In this study, amplitude modulation (AM) detection thresholds were measured for 550 and 5000 Hz carriers with and without concurrent frequency modulation (FM), at AM rates crucial for speech perception. Results indicate that adding 40 Hz FM interferes with AM detection, more so for 5000 Hz carrier and for frequency deviations exceeding the critical bandwidth of the carrier frequency. These findings suggest that future cochlear implant processors, encoding speech fine-structures may consider limiting the FM to narrow bandwidth and to low frequencies.

  7. Gluon amplitudes as 2 d conformal correlators

    Science.gov (United States)

    Pasterski, Sabrina; Shao, Shu-Heng; Strominger, Andrew

    2017-10-01

    Recently, spin-one wave functions in four dimensions that are conformal primaries of the Lorentz group S L (2 ,C ) were constructed. We compute low-point, tree-level gluon scattering amplitudes in the space of these conformal primary wave functions. The answers have the same conformal covariance as correlators of spin-one primaries in a 2 d CFT. The Britto-Cachazo-Feng-Witten (BCFW) recursion relation between three- and four-point gluon amplitudes is recast into this conformal basis.

  8. Precise generator of stability amplitude pulses

    International Nuclear Information System (INIS)

    Zhuk, N.A.; Zdesenko, Yu.G.; Kuts, V.N.

    1989-01-01

    A generator of stability amplitude pulses, designed for stabilization of a low-noise semiconducting spectrometer, used in investigations of 76 Ge2β-decay, is described. The generator contains a permanent-voltage source, a storage element and a switch based on a Hg relay. A thermostatic source provides a relative voltage instability less than ±5x10 -6 per 80h (standard deviation). The Hg relay is placed into a separate thermostat. The relative instability of output generator pulse amplitude does not exceed ±1.5x10 -5 per 24h

  9. High energy multi-gluon exchange amplitudes

    International Nuclear Information System (INIS)

    Jaroszewicz, T.

    1980-11-01

    We examine perturbative high energy n-gluon exchange amplitudes calculated in the Coulomb gauge. If n exceeds the minimum required by the t-channel quantum numbers, such amplitudes are non-leading in lns. We derive a closed system of coupled integral equations for the corresponding two-particle n-gluon vertices, obtained by summing the leading powers of ln(N μ psup(μ)), where psup(μ) is the incident momentum and Nsup(μ) the gauge-defining vector. Our equations are infra-red finite, provided the external particles are colour singlets. (author)

  10. Personality and the collective: bold homing pigeons occupy higher leadership ranks in flocks.

    Science.gov (United States)

    Sasaki, Takao; Mann, Richard P; Warren, Katherine N; Herbert, Tristian; Wilson, Tara; Biro, Dora

    2018-05-19

    While collective movement is ecologically widespread and conveys numerous benefits on individuals, it also poses a coordination problem: who controls the group's movements? The role that animal 'personalities' play in this question has recently become a focus of research interest. Although many animal groups have distributed leadership (i.e. multiple individuals influence collective decisions), studies linking personality and leadership have focused predominantly on the group's single most influential individual. In this study, we investigate the relationship between personality and the influence of multiple leaders on collective movement using homing pigeons, Columba livia , a species known to display complex multilevel leadership hierarchies during flock flights. Our results show that more exploratory (i.e. 'bold') birds are more likely to occupy higher ranks in the leadership hierarchy and thus have more influence on the direction of collective movement than less exploratory (i.e. 'shy') birds during both free flights around their lofts and homing flights from a distant site. Our data also show that bold pigeons fly faster than shy birds during solo flights. We discuss our results in light of theories about the evolution of personality, with specific reference to the adaptive value of heterogeneity in animal groups.This article is part of the theme issue 'Collective movement ecology'. © 2018 The Author(s).

  11. Olfactory responses to natal stream water in sockeye salmon by BOLD fMRI.

    Directory of Open Access Journals (Sweden)

    Hiroshi Bandoh

    Full Text Available Many studies have shown that juvenile salmon imprint olfactory memory of natal stream odors during downstream migration, and adults recall this stream-specific odor information to discriminate their natal stream during upstream migration for spawning. The odor information processing of the natal stream in the salmon brain, however, has not been clarified. We applied blood oxygenation level-dependent (BOLD functional magnetic resonance imaging to investigate the odor information processing of the natal stream in the olfactory bulb and telencephalon of lacustrine sockeye salmon (Oncorhynchus nerka. The strong responses to the natal stream water were mainly observed in the lateral area of dorsal telencephalon (Dl, which are homologous to the medial pallium (hippocampus in terrestrial vertebrates. Although the concentration of L-serine (1 mM in the control water was 20,000-times higher than that of total amino acid in the natal stream water (47.5 nM, the BOLD signals resulting from the natal stream water were stronger than those by L-serine in the Dl. We concluded that sockeye salmon could process the odor information of the natal stream by integrating information in the Dl area of the telencephalon.

  12. Intraindividual variability of boldness is repeatable across contexts in a wild lizard.

    Directory of Open Access Journals (Sweden)

    Laura Highcock

    Full Text Available Animals do not behave in exactly the same way when repeatedly tested in the same context or situation, even once systematic variation, such as habituation, has been controlled for. This unpredictability is called intraindividual variability (IIV and has been little studied in animals. Here we investigated how IIV in boldness (estimated by flight initiation distances changed across two seasons--the dry, non-breeding season and the wet, breeding season--in a wild population of the Namibian rock agama, Agama planiceps. We found significant differences in IIV both between individuals and seasons, and IIV was higher in the wet season, suggesting plasticity in IIV. Further, IIV was highly repeatable (r = 0.61 between seasons and we found strong negative correlations between consistent individual differences in flight initiation distances, i.e. their boldness, and individuals' IIVs. We suggest that to understand personality in animals, researchers should generate a personality 'profile' that includes not only the relative level of a trait (i.e. its personality, but also its plasticity and variability under natural conditions.

  13. Unemployment in chronic airflow obstruction around the world: results from the BOLD study.

    Science.gov (United States)

    Grønseth, Rune; Erdal, Marta; Tan, Wan C; Obaseki, Daniel O; Amaral, Andre F S; Gislason, Thorarinn; Juvekar, Sanjay K; Koul, Parvaiz A; Studnicka, Michael; Salvi, Sundeep; Burney, Peter; Buist, A Sonia; Vollmer, William M; Johannessen, Ane

    2017-09-01

    We aimed to examine associations between chronic airflow obstruction (CAO) and unemployment across the world.Cross-sectional data from 26 sites in the Burden of Obstructive Lung Disease (BOLD) study were used to analyse effects of CAO on unemployment. Odds ratios for unemployment in subjects aged 40-65 years were estimated using a multilevel mixed-effects generalised linear model with study site as random effect. Site-by-site heterogeneity was assessed using individual participant data meta-analyses.Out of 18 710 participants, 11.3% had CAO. The ratio of unemployed subjects with CAO divided by subjects without CAO showed large site discrepancies, although these were no longer significant after adjusting for age, sex, smoking and education. The site-adjusted odds ratio (95% CI) for unemployment was 1.79 (1.41-2.27) for CAO cases, decreasing to 1.43 (1.14-1.79) after adjusting for sociodemographic factors, comorbidities and forced vital capacity. Of other covariates that were associated with unemployment, age and education were important risk factors in high-income sites (4.02 (3.53-4.57) and 3.86 (2.80-5.30), respectively), while female sex was important in low- to middle-income sites (3.23 (2.66-3.91)).In the global BOLD study, CAO was associated with increased levels of unemployment, even after adjusting for sociodemographic factors, comorbidities and lung function. Copyright ©ERS 2017.

  14. MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changes

    Directory of Open Access Journals (Sweden)

    Sergey M Plis

    2010-11-01

    Full Text Available The combined analysis of MEG/EEG and functional MRI measurements can lead to improvement in the description of the dynamical and spatial properties of brain activity. In this paper we empirically demonstrate this improvement using simulated and recorded task related MEG and fMRI activity. Neural activity estimates were derived using a dynamic Bayesian network with continuous real valued parameters by means of a sequential Monte Carlo technique. In synthetic data, we show that MEG and fMRI fusion improves estimation of the indirectly observed neural activity and smooths tracking of the BOLD response. In recordings of task related neural activity the combination of MEG and fMRI produces a result with greater SNR, that confirms the expectation arising from the nature of the experiment. The highly nonlinear model of the BOLD response poses a difficult inference problem for neural activity estimation; computational requirements are also high due to the time and space complexity. We show that joint analysis of the data improves the system's behavior by stabilizing the differential equations system and by requiring fewer computational resources.

  15. Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis.

    Directory of Open Access Journals (Sweden)

    E Castaldi

    2016-10-01

    Full Text Available Retinal prosthesis technologies require that the visual system downstream of the retinal circuitry be capable of transmitting and elaborating visual signals. We studied the capability of plastic remodeling in late blind subjects implanted with the Argus II Retinal Prosthesis with psychophysics and functional MRI (fMRI. After surgery, six out of seven retinitis pigmentosa (RP blind subjects were able to detect high-contrast stimuli using the prosthetic implant. However, direction discrimination to contrast modulated stimuli remained at chance level in all of them. No subject showed any improvement of contrast sensitivity in either eye when not using the Argus II. Before the implant, the Blood Oxygenation Level Dependent (BOLD activity in V1 and the lateral geniculate nucleus (LGN was very weak or absent. Surprisingly, after prolonged use of Argus II, BOLD responses to visual input were enhanced. This is, to our knowledge, the first study tracking the neural changes of visual areas in patients after retinal implant, revealing a capacity to respond to restored visual input even after years of deprivation.

  16. Low prevalence of obstructive lung disease in a suburban population of Malaysia: A BOLD collaborative study.

    Science.gov (United States)

    Loh, Li Cher; Rashid, Abdul; Sholehah, Siti; Gnatiuc, Louisa; Patel, Jaymini H; Burney, Peter

    2016-08-01

    As a Burden of Obstructive Lung Disease (BOLD) collaboration, we studied the prevalence of chronic obstructive pulmonary disease (COPD) and its associated risk factors in a suburban population in Malaysia. Nonhospitalized men or women of age ≥ 40 years from a Penang district were recruited by stratified simple random sampling. Participants completed detailed questionnaires on respiratory symptoms and exposure to COPD risk factors. Prebronchodilator and post-bronchodilator spirometry conducted was standardized across all international BOLD sites in device and data quality control. Of the 1218 individuals recruited for the study, 663 (340 men and 323 women) had complete questionnaire data and acceptable post-bronchodilator spirometry. The estimated population prevalence of Global Initiative for Chronic Obstructive Lung Disease (GOLD) ≥ stage I was 6.5% or 3.4% based on either fixed forced expiratory volume in 1 s/forced vital capacity ratio of population-based epidemiology data on COPD for Malaysia. Compared with other sites globally, our estimated population prevalence was relatively low. In addition to cigarette smoking, use of biomass fuel and exposure to dusty job represented significant risk to the development of COPD. © 2016 Asian Pacific Society of Respirology.

  17. Increased BOLD activation to predator stressor in subiculum and midbrain of amphetamine-sensitized maternal rats.

    Science.gov (United States)

    Febo, Marcelo; Pira, Ashley S

    2011-03-25

    Amphetamine, which is known to cause sensitization, potentiates the hormonal and neurobiological signatures of stress and may also increase sensitivity to stress-inducing stimuli in limbic areas. Trimethylthiazoline (5μL TMT) is a chemical constituent of fox feces that evokes innate fear and activates the neuronal and hormonal signatures of stress in rats. We used blood oxygen level dependent (BOLD) MRI to test whether amphetamine sensitization (1mg/kg, i.p. ×3days) in female rats has a lasting effect on the neural response to a stress-evoking stimulus, the scent of a predator, during the postpartum period. The subiculum and dopamine-enriched midbrain VTA/SN of amphetamine-sensitized but not control mothers showed a greater BOLD signal response to predator odor than a control putrid scent. The greater responsiveness of these two brain regions following stimulant sensitization might impact neural processing in response to stressors in the maternal brain. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. Exploring BOLD changes during spatial attention in non-stimulated visual cortex.

    Directory of Open Access Journals (Sweden)

    Linda Heinemann

    Full Text Available Blood oxygen level-dependent (BOLD responses were measured in parts of primary visual cortex that represented unstimulated visual field regions at different distances from a stimulated central target location. The composition of the visual scene varied by the presence or absence of additional peripheral distracter stimuli. Bottom-up effects were assessed by comparing peripheral activity during central stimulation vs. no stimulation. Top-down effects were assessed by comparing active vs. passive conditions. In passive conditions subjects simply watched the central letter stimuli and in active conditions they had to report occurrence of pre-defined targets in a rapid serial letter stream. Onset of the central letter stream enhanced activity in V1 representations of the stimulated region. Within representations of the periphery activation decreased and finally turned into deactivation with increasing distance from the stimulated location. This pattern was most pronounced in the active conditions and during the presence of peripheral stimuli. Active search for a target did not lead to additional enhancement at areas representing the attentional focus but to a stronger deactivation in the vicinity. Suppressed neuronal activity was also found in the non distracter condition suggesting a top-down attention driven effect. Our observations suggest that BOLD signal decreases in primary visual cortex are modulated by bottom-up sensory-driven factors such as the presence of distracters in the visual field as well as by top-down attentional processes.

  19. fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families.

    Science.gov (United States)

    Hill, Shirley Y; Kostelnik, Bryan; Holmes, Brian; Goradia, Dhruman; McDermott, Michael; Diwadkar, Vaibhav; Keshavan, Matcheri

    2007-12-01

    Increased susceptibility for developing alcohol dependence (AD) may be related to structural and functional differences in brain circuits that influence social cognition and more specifically, theory of mind (ToM). Alcohol dependent individuals have a greater likelihood of having deficits in social skills and greater social alienation. These characteristics may be related to inherited differences in the neuroanatomical network that comprises the social brain. Adolescent/young adult participants from multiplex AD families and controls (n = 16) were matched for gender, age, IQ, education, and handedness and administered the Eyes Task of Baron-Cohen during functional magnetic resonance imaging (fMRI). High-risk (HR) subjects showed significantly diminished blood oxygen level dependent (BOLD) response in comparison with low-risk control young adults in the right middle temporal gyrus (RMTG) and the left inferior frontal gyrus (LIFG), areas that have previously been implicated in ToM tasks. Offspring from multiplex families for AD may manifest one aspect of their genetic susceptibility by having a diminished BOLD response in brain regions associated with performance of ToM tasks. These results suggest that those at risk for developing AD may have reduced ability to empathize with others' state of mind, possibly resulting in diminished social skill.

  20. Rearing environment influences boldness and prey acquisition behavior, and brain and lens development of bull trout

    Science.gov (United States)

    Brignon, William R.; Pike, Martin M.; Ebbesson, Lars O.E.; Schaller, Howard A.; Peterson, James T.; Schreck, Carl B.

    2018-01-01

    Animals reared in barren captive environments exhibit different developmental trajectories and behaviors than wild counterparts. Hence, the captive phenotypes may influence the success of reintroduction and recovery programs for threatened and endangered species. We collected wild bull trout embryos from the Metolius River Basin, Oregon and reared them in differing environments to better understand how captivity affects the bull trout Salvelinus confluentusphenotype. We compared the boldness and prey acquisition behaviors and development of the brain and eye lens of bull trout reared in conventional barren and more structurally complex captive environments with that of wild fish. Wild fish and captive reared fish from complex habitats exhibited a greater level of boldness and prey acquisition ability, than fish reared in conventional captive environments. In addition, the eye lens of conventionally reared bull trout was larger than complex reared captive fish or same age wild fish. Interestingly, we detected wild fish had a smaller relative cerebellum than either captive reared treatment. Our results suggest that rearing fish in more complex captive environments can create a more wild-like phenotype than conventional rearing practices. A better understanding of the effects of captivity on the development and behavior of bull trout can inform rearing and reintroduction programs though prediction of the performance of released individuals.

  1. Detecting Activation in fMRI Data: An Approach Based on Sparse Representation of BOLD Signal

    Directory of Open Access Journals (Sweden)

    Blanca Guillen

    2018-01-01

    Full Text Available This paper proposes a simple yet effective approach for detecting activated voxels in fMRI data by exploiting the inherent sparsity property of the BOLD signal in temporal and spatial domains. In the time domain, the approach combines the General Linear Model (GLM with a Least Absolute Deviation (LAD based regression method regularized by the pseudonorm l0 to promote sparsity in the parameter vector of the model. In the spatial domain, detection of activated regions is based on thresholding the spatial map of estimated parameters associated with a particular stimulus. The threshold is calculated by exploiting the sparseness of the BOLD signal in the spatial domain assuming a Laplacian distribution model. The proposed approach is validated using synthetic and real fMRI data. For synthetic data, results show that the proposed approach is able to detect most activated voxels without any false activation. For real data, the method is evaluated through comparison with the SPM software. Results indicate that this approach can effectively find activated regions that are similar to those found by SPM, but using a much simpler approach. This study may lead to the development of robust spatial approaches to further simplifying the complexity of classical schemes.

  2. Background MR gradient noise and non-auditory BOLD activations: a data-driven perspective.

    Science.gov (United States)

    Haller, Sven; Homola, György A; Scheffler, Klaus; Beckmann, Christian F; Bartsch, Andreas J

    2009-07-28

    The effect of echoplanar imaging (EPI) acoustic background noise on blood oxygenation level dependent (BOLD) activations was investigated. Two EPI pulse sequences were compared: (i) conventional EPI with a pulsating sound component of typically 8-10 Hz, which is a potent physiological stimulus, and (ii) the more recently developed continuous-sound EPI, which is perceived as less distractive despite equivalent peak sound pressure levels. Sixteen healthy subjects performed an established demanding visual n-back working memory task. Using an exploratory data analysis technique (tensorial probabilistic independent component analysis; tensor-PICA), we studied the inter-session/within-subject response variability introduced by continuous-sound versus conventional EPI acoustic background noise in addition to temporal and spatial signal characteristics. The analysis revealed a task-related component associated with the established higher-level working memory and motor feedback response network, which exhibited a significant 19% increase in its average effect size for the continuous-sound as opposed to conventional EPI. Stimulus-related lower-level activations, such as primary visual areas, were not modified. EPI acoustic background noise influences much more than the auditory system per se. This analysis provides additional evidence for an enhancement of task-related, extra-auditory BOLD activations by continuous-sound EPI due to less distractive acoustic background gradient noise.

  3. Nonlinear Bayesian Estimation of BOLD Signal under Non-Gaussian Noise

    Directory of Open Access Journals (Sweden)

    Ali Fahim Khan

    2015-01-01

    Full Text Available Modeling the blood oxygenation level dependent (BOLD signal has been a subject of study for over a decade in the neuroimaging community. Inspired from fluid dynamics, the hemodynamic model provides a plausible yet convincing interpretation of the BOLD signal by amalgamating effects of dynamic physiological changes in blood oxygenation, cerebral blood flow and volume. The nonautonomous, nonlinear set of differential equations of the hemodynamic model constitutes the process model while the weighted nonlinear sum of the physiological variables forms the measurement model. Plagued by various noise sources, the time series fMRI measurement data is mostly assumed to be affected by additive Gaussian noise. Though more feasible, the assumption may cause the designed filter to perform poorly if made to work under non-Gaussian environment. In this paper, we present a data assimilation scheme that assumes additive non-Gaussian noise, namely, the e-mixture noise, affecting the measurements. The proposed filter MAGSF and the celebrated EKF are put to test by performing joint optimal Bayesian filtering to estimate both the states and parameters governing the hemodynamic model under non-Gaussian environment. Analyses using both the synthetic and real data reveal superior performance of the MAGSF as compared to EKF.

  4. Ghrelin modulates the fMRI BOLD response of homeostatic and hedonic brain centers regulating energy balance in the rat.

    Directory of Open Access Journals (Sweden)

    Miklós Sárvári

    Full Text Available The orexigenic gut-brain peptide, ghrelin and its G-protein coupled receptor, the growth hormone secretagogue receptor 1a (GHS-R1A are pivotal regulators of hypothalamic feeding centers and reward processing neuronal circuits of the brain. These systems operate in a cooperative manner and receive a wide array of neuronal hormone/transmitter messages and metabolic signals. Functional magnetic resonance imaging was employed in the current study to map BOLD responses to ghrelin in different brain regions with special reference on homeostatic and hedonic regulatory centers of energy balance. Experimental groups involved male, ovariectomized female and ovariectomized estradiol-replaced rats. Putative modulation of ghrelin signaling by endocannabinoids was also studied. Ghrelin-evoked effects were calculated as mean of the BOLD responses 30 minutes after administration. In the male rat, ghrelin evoked a slowly decreasing BOLD response in all studied regions of interest (ROI within the limbic system. This effect was antagonized by pretreatment with GHS-R1A antagonist JMV2959. The comparison of ghrelin effects in the presence or absence of JMV2959 in individual ROIs revealed significant changes in the prefrontal cortex, nucleus accumbens of the telencephalon, and also within hypothalamic centers like the lateral hypothalamus, ventromedial nucleus, paraventricular nucleus and suprachiasmatic nucleus. In the female rat, the ghrelin effects were almost identical to those observed in males. Ovariectomy and chronic estradiol replacement had no effect on the BOLD response. Inhibition of the endocannabinoid signaling by rimonabant significantly attenuated the response of the nucleus accumbens and septum. In summary, ghrelin can modulate hypothalamic and mesolimbic structures controlling energy balance in both sexes. The endocannabinoid signaling system contributes to the manifestation of ghrelin's BOLD effect in a region specific manner. In females, the

  5. Maximum Entropy in Drug Discovery

    Directory of Open Access Journals (Sweden)

    Chih-Yuan Tseng

    2014-07-01

    Full Text Available Drug discovery applies multidisciplinary approaches either experimentally, computationally or both ways to identify lead compounds to treat various diseases. While conventional approaches have yielded many US Food and Drug Administration (FDA-approved drugs, researchers continue investigating and designing better approaches to increase the success rate in the discovery process. In this article, we provide an overview of the current strategies and point out where and how the method of maximum entropy has been introduced in this area. The maximum entropy principle has its root in thermodynamics, yet since Jaynes’ pioneering work in the 1950s, the maximum entropy principle has not only been used as a physics law, but also as a reasoning tool that allows us to process information in hand with the least bias. Its applicability in various disciplines has been abundantly demonstrated. We give several examples of applications of maximum entropy in different stages of drug discovery. Finally, we discuss a promising new direction in drug discovery that is likely to hinge on the ways of utilizing maximum entropy.

  6. Amplitude ratios in ρ0 leptoproductions and GPDs

    Directory of Open Access Journals (Sweden)

    Goloskokov S.V.

    2017-01-01

    Using the model results we calculate the ratio of different helicity amplitudes for a transversely polarized proton target to the leading twist longitudinal amplitude. Our results are close to the amplitude ratios measured by HERMES.

  7. "To Boldly Go" versus "Last, Best Hope" : The Future of Human Civilization as Depicted in American Science Fiction

    OpenAIRE

    Glasø, Alexander

    2012-01-01

    "'To Boldly Go" versus "Last, Best Hope'" examines a total of four American television series from the Star Trek and Babylon 5 franchises, and the portrayal of human civilization in the future. The thesis traces how Star Trek set out "to boldly go" and how Babylon 5 was the "last, best hope" in depicting a coherent, futuristic vision for humanity. The initial chapter focuses on the background of the series and also the ways they differed from one another, while chapter 2 is devoted to the por...

  8. Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation

    DEFF Research Database (Denmark)

    Kim, S.G.; Rostrup, Egill; Larsson, H.B.

    1999-01-01

    signal changes were measured simultaneously using the flow-sensitive alternating inversion recovery (FAIR) technique. During hypercapnia established by an end-tidal CO2 increase of 1.46 kPa, CBF in the visual cortex increased by 47.3 +/- 17.3% (mean +/- SD; n = 9), and deltaR2* was -0.478 +/- 0.147 sec......The blood oxygenation level-dependent (BOLD) effect in functional magnetic resonance imaging depends on at least partial uncoupling between cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) changes. By measuring CBF and BOLD simultaneously, the relative change in CMRO2 can...

  9. The role of ecological context and predation risk-stimuli in revealing the true picture about the genetic basis of boldness evolution in fish

    DEFF Research Database (Denmark)

    Klefoth, Thomas; Skov, Christian; Krause, Jens

    2011-01-01

    To showcase the importance of genotype × environment interactions and the presence of predation risk in the experimental assessment of boldness in fish, we investigated boldness in terms of feeding behavior and refuge use in two genetically different populations of juvenile carp (Cyprinus carpio)...

  10. Stora's fine notion of divergent amplitudes

    Directory of Open Access Journals (Sweden)

    Joseph C. Várilly

    2016-11-01

    Full Text Available Stora and coworkers refined the notion of divergent quantum amplitude, somewhat upsetting the standard power-counting recipe. This unexpectedly clears the way to new prototypes for free and interacting field theories of bosons of any mass and spin.

  11. Connected formulas for amplitudes in standard model

    Energy Technology Data Exchange (ETDEWEB)

    He, Song [CAS Key Laboratory of Theoretical Physics,Institute of Theoretical Physics, Chinese Academy of Sciences,Beijing 100190 (China); School of Physical Sciences, University of Chinese Academy of Sciences,No. 19A Yuquan Road, Beijing 100049 (China); Zhang, Yong [Department of Physics, Beijing Normal University,Beijing 100875 (China); CAS Key Laboratory of Theoretical Physics,Institute of Theoretical Physics, Chinese Academy of Sciences,Beijing 100190 (China)

    2017-03-17

    Witten’s twistor string theory has led to new representations of S-matrix in massless QFT as a single object, including Cachazo-He-Yuan formulas in general and connected formulas in four dimensions. As a first step towards more realistic processes of the standard model, we extend the construction to QCD tree amplitudes with massless quarks and those with a Higgs boson. For both cases, we find connected formulas in four dimensions for all multiplicities which are very similar to the one for Yang-Mills amplitudes. The formula for quark-gluon color-ordered amplitudes differs from the pure-gluon case only by a Jacobian factor that depends on flavors and orderings of the quarks. In the formula for Higgs plus multi-parton amplitudes, the massive Higgs boson is effectively described by two additional massless legs which do not appear in the Parke-Taylor factor. The latter also represents the first twistor-string/connected formula for form factors.

  12. Fatigue Reliability under Multiple-Amplitude Loads

    DEFF Research Database (Denmark)

    Talreja, R.

    1979-01-01

    for the initial tensile strength and the fatigue life, the probability distributions for the residual tensile strength in both the crack initiation and the crack propagation stages of fatigue are determined. The method is illustrated for two-amplitude loads by means of experimental results obtained by testing...

  13. Ward identities for amplitudes with reggeized gluons

    International Nuclear Information System (INIS)

    Bartles, J.; Vacca, G.P.

    2012-05-01

    Starting from the effective action of high energy QCD we derive Ward identities for Green's functions of reggeized gluons. They follow from the gauge invariance of the effective action, and allow to derive new representations of amplitudes containing physical particles as well as reggeized gluons. We explicitly demonstrate their validity for the BFKL kernel, and we present a new derivation of the kernel.

  14. Scattering amplitudes in super-renormalizable gravity

    International Nuclear Information System (INIS)

    Donà, Pietro; Giaccari, Stefano; Modesto, Leonardo; Rachwał, Lesław; Zhu, Yiwei

    2015-01-01

    We explicitly compute the tree-level on-shell four-graviton amplitudes in four, five and six dimensions for local and weakly nonlocal gravitational theories that are quadratic in both, the Ricci and scalar curvature with form factors of the d’Alembertian operator inserted between. More specifically we are interested in renormalizable, super-renormalizable or finite theories. The scattering amplitudes for these theories turn out to be the same as the ones of Einstein gravity regardless of the explicit form of the form factors. As a special case the four-graviton scattering amplitudes in Weyl conformal gravity are identically zero. Using a field redefinition, we prove that the outcome is correct for any number of external gravitons (on-shell n−point functions) and in any dimension for a large class of theories. However, when an operator quadratic in the Riemann tensor is added in any dimension (with the exception of the Gauss-Bonnet term in four dimensions) the result is completely altered, and the scattering amplitudes depend on all the form factors introduced in the action.

  15. Particle Distribution Modification by Low Amplitude Modes

    International Nuclear Information System (INIS)

    White, R.B.; Gorelenkov, N.; Heidbrink, W.W.; Van Zeeland, M.A.

    2009-01-01

    Modification of a high energy particle distribution by a spectrum of low amplitude modes is investigated using a guiding center code. Only through resonance are modes effective in modifying the distribution. Diagnostics are used to illustrate the mode-particle interaction and to find which effects are relevant in producing significant resonance, including kinetic Poincare plots and plots showing those orbits with time averaged mode-particle energy transfer. Effects of pitch angle scattering and drag are studied, as well as plasma rotation and time dependence of the equilibrium and mode frequencies. A specific example of changes observed in a DIII-D deuterium beam distribution in the presence of low amplitude experimentally validated Toroidal Alfven (TAE) eigenmodes and Reversed Shear Alfven (RSAE) eigenmodes is examined in detail. Comparison with experimental data shows that multiple low amplitude modes can account for significant modification of high energy beam particle distributions. It is found that there is a stochastic threshold for beam profile modification, and that the experimental amplitudes are only slightly above this threshold.

  16. Kaon decay amplitudes using staggered fermions

    International Nuclear Information System (INIS)

    Sharpe, S.R.

    1986-12-01

    A status report is given of an attempt, using staggered fermions to calculate the real and imaginary parts of the amplitudes for K → ππ,. Semi-quantitative results are found for the imaginary parts, and these suggest that ε' might be smaller than previously expected in the standard model

  17. Constraints on low energy Compton scattering amplitudes

    International Nuclear Information System (INIS)

    Raszillier, I.

    1979-04-01

    We derive the constraints and correlations of fairly general type for Compton scattering amplitudes at energies below photoproduction threshold and fixed momentum transfer, following from (an upper bound on) the corresponding differential cross section above photoproduction threshold. The derivation involves the solution of an extremal problem in a certain space of vector - valued analytic functions. (author)

  18. Analytic properties of many-particle amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Medvedev, B V; Pavlov, V P; Polivanov, M K; Sukhanov, A D [Gosudarstvennyj Komitet po Ispol' zovaniyu Atomnoj Ehnergii SSSR, Moscow. Inst. Teoreticheskoj i Ehksperimental' noj Fiziki; AN SSSR, Moscow. Matematicheskij Inst.)

    1982-08-01

    In the framework of N. N. Bogolyubov axiomatic approach the complete proof of the existence of an analytic function the boundary values of which are the amplitudes of any channel of n-particle process is given. The one-particle structure of this function is described.

  19. Maximum stellar iron core mass

    Indian Academy of Sciences (India)

    60, No. 3. — journal of. March 2003 physics pp. 415–422. Maximum stellar iron core mass. F W GIACOBBE. Chicago Research Center/American Air Liquide ... iron core compression due to the weight of non-ferrous matter overlying the iron cores within large .... thermal equilibrium velocities will tend to be non-relativistic.

  20. Maximum entropy beam diagnostic tomography

    International Nuclear Information System (INIS)

    Mottershead, C.T.

    1985-01-01

    This paper reviews the formalism of maximum entropy beam diagnostic tomography as applied to the Fusion Materials Irradiation Test (FMIT) prototype accelerator. The same formalism has also been used with streak camera data to produce an ultrahigh speed movie of the beam profile of the Experimental Test Accelerator (ETA) at Livermore. 11 refs., 4 figs

  1. Maximum entropy beam diagnostic tomography

    International Nuclear Information System (INIS)

    Mottershead, C.T.

    1985-01-01

    This paper reviews the formalism of maximum entropy beam diagnostic tomography as applied to the Fusion Materials Irradiation Test (FMIT) prototype accelerator. The same formalism has also been used with streak camera data to produce an ultrahigh speed movie of the beam profile of the Experimental Test Accelerator (ETA) at Livermore

  2. A portable storage maximum thermometer

    International Nuclear Information System (INIS)

    Fayart, Gerard.

    1976-01-01

    A clinical thermometer storing the voltage corresponding to the maximum temperature in an analog memory is described. End of the measurement is shown by a lamp switch out. The measurement time is shortened by means of a low thermal inertia platinum probe. This portable thermometer is fitted with cell test and calibration system [fr

  3. Neutron spectra unfolding with maximum entropy and maximum likelihood

    International Nuclear Information System (INIS)

    Itoh, Shikoh; Tsunoda, Toshiharu

    1989-01-01

    A new unfolding theory has been established on the basis of the maximum entropy principle and the maximum likelihood method. This theory correctly embodies the Poisson statistics of neutron detection, and always brings a positive solution over the whole energy range. Moreover, the theory unifies both problems of overdetermined and of underdetermined. For the latter, the ambiguity in assigning a prior probability, i.e. the initial guess in the Bayesian sense, has become extinct by virtue of the principle. An approximate expression of the covariance matrix for the resultant spectra is also presented. An efficient algorithm to solve the nonlinear system, which appears in the present study, has been established. Results of computer simulation showed the effectiveness of the present theory. (author)

  4. Spectral Amplitude Coding (SAC)-OCDMA Network with 8DPSK

    Science.gov (United States)

    Aldhaibani, A. O.; Aljunid, S. A.; Fadhil, Hilal A.; Anuar, M. S.

    2013-09-01

    Optical code division multiple access (OCDMA) technique is required to meet the increased demand for high speed, large capacity communications in optical networks. In this paper, the transmission performance of a spectral amplitude coding (SAC)-OCDMA network is investigated when a conventional single-mode fiber (SMF) is used as the transmission link using 8DPSK modulation. The DW has a fixed weight of two. Simulation results reveal that the transmission distance is limited mainly by the fiber dispersion when high coding chip rate is used. For a two-user SAC-OCDMA network operating with 2 Gbit/s data rate and two wavelengths for each user, the maximum allowable transmission distance is about 15 km.

  5. Modeling Encapsulated Microbubble Dynamics at High Pressure Amplitudes

    Science.gov (United States)

    Heyse, Jan F.; Bose, Sanjeeb; Iaccarino, Gianluca

    2017-11-01

    Encapsulated microbubbles are commonly used in ultrasound contrast imaging and are of growing interest in therapeutic applications where local cavitation creates temporary perforations in cell membranes allowing for enhanced drug delivery. Clinically used microbubbles are encapsulated by a shell commonly consisting of protein, polymer, or phospholipid; the response of these bubbles to externally imposed ultrasound waves is sensitive to the compressibility of the encapsulating shell. Existing models approximate the shell compressibility via an effective surface tension (Marmottant et al. 2005). We present simulations of microbubbles subjected to high amplitude ultrasound waves (on the order of 106 Pa) and compare the results with the experimental measurements of Helfield et al. (2016). Analysis of critical points (corresponding to maximum and minimum expansion) in the governing Rayleigh-Plesset equation is used to make estimates of the parameters used to characterize the effective surface tension of the encapsulating shell. Stanford Graduate Fellowship.

  6. Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy

    Science.gov (United States)

    Peterchev, Angel V; Krystal, Andrew D; Rosa, Moacyr A; Lisanby, Sarah H

    2015-01-01

    Electroconvulsive therapy (ECT) at conventional current amplitudes (800–900 mA) is highly effective but carries the risk of cognitive side effects. Lowering and individualizing the current amplitude may reduce side effects by virtue of a less intense and more focal electric field exposure in the brain, but this aspect of ECT dosing is largely unexplored. Magnetic seizure therapy (MST) induces a weaker and more focal electric field than ECT; however, the pulse amplitude is not individualized and the minimum amplitude required to induce a seizure is unknown. We titrated the amplitude of long stimulus trains (500 pulses) as a means of determining the minimum current amplitude required to induce a seizure with ECT (bilateral, right unilateral, bifrontal, and frontomedial electrode placements) and MST (round coil on vertex) in nonhuman primates. Furthermore, we investigated a novel method of predicting this amplitude-titrated seizure threshold (ST) by a non-convulsive measurement of motor threshold (MT) using single pulses delivered through the ECT electrodes or MST coil. Average STs were substantially lower than conventional pulse amplitudes (112–174 mA for ECT and 37.4% of maximum device amplitude for MST). ST was more variable in ECT than in MST. MT explained 63% of the ST variance and is hence the strongest known predictor of ST. These results indicate that seizures can be induced with less intense electric fields than conventional ECT that may be safer; efficacy and side effects should be evaluated in clinical studies. MT measurement could be a faster and safer alternative to empirical ST titration for ECT and MST. PMID:25920013

  7. Comparison of Travel-Time and Amplitude Measurements for Deep-Focusing Time-Distance Helioseismology

    Science.gov (United States)

    Pourabdian, Majid; Fournier, Damien; Gizon, Laurent

    2018-04-01

    The purpose of deep-focusing time-distance helioseismology is to construct seismic measurements that have a high sensitivity to the physical conditions at a desired target point in the solar interior. With this technique, pairs of points on the solar surface are chosen such that acoustic ray paths intersect at this target (focus) point. Considering acoustic waves in a homogeneous medium, we compare travel-time and amplitude measurements extracted from the deep-focusing cross-covariance functions. Using a single-scattering approximation, we find that the spatial sensitivity of deep-focusing travel times to sound-speed perturbations is zero at the target location and maximum in a surrounding shell. This is unlike the deep-focusing amplitude measurements, which have maximum sensitivity at the target point. We compare the signal-to-noise ratio for travel-time and amplitude measurements for different types of sound-speed perturbations, under the assumption that noise is solely due to the random excitation of the waves. We find that, for highly localized perturbations in sound speed, the signal-to-noise ratio is higher for amplitude measurements than for travel-time measurements. We conclude that amplitude measurements are a useful complement to travel-time measurements in time-distance helioseismology.

  8. Hydraulic Limits on Maximum Plant Transpiration

    Science.gov (United States)

    Manzoni, S.; Vico, G.; Katul, G. G.; Palmroth, S.; Jackson, R. B.; Porporato, A. M.

    2011-12-01

    Photosynthesis occurs at the expense of water losses through transpiration. As a consequence of this basic carbon-water interaction at the leaf level, plant growth and ecosystem carbon exchanges are tightly coupled to transpiration. In this contribution, the hydraulic constraints that limit transpiration rates under well-watered conditions are examined across plant functional types and climates. The potential water flow through plants is proportional to both xylem hydraulic conductivity (which depends on plant carbon economy) and the difference in water potential between the soil and the atmosphere (the driving force that pulls water from the soil). Differently from previous works, we study how this potential flux changes with the amplitude of the driving force (i.e., we focus on xylem properties and not on stomatal regulation). Xylem hydraulic conductivity decreases as the driving force increases due to cavitation of the tissues. As a result of this negative feedback, more negative leaf (and xylem) water potentials would provide a stronger driving force for water transport, while at the same time limiting xylem hydraulic conductivity due to cavitation. Here, the leaf water potential value that allows an optimum balance between driving force and xylem conductivity is quantified, thus defining the maximum transpiration rate that can be sustained by the soil-to-leaf hydraulic system. To apply the proposed framework at the global scale, a novel database of xylem conductivity and cavitation vulnerability across plant types and biomes is developed. Conductivity and water potential at 50% cavitation are shown to be complementary (in particular between angiosperms and conifers), suggesting a tradeoff between transport efficiency and hydraulic safety. Plants from warmer and drier biomes tend to achieve larger maximum transpiration than plants growing in environments with lower atmospheric water demand. The predicted maximum transpiration and the corresponding leaf water

  9. Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T

    NARCIS (Netherlands)

    Jorge, João; Figueiredo, Patrícia; Gruetter, Rolf; Van der Zwaag, W.

    External stimuli and tasks often elicit negative BOLD responses in various brain regions, and growing experimental evidence supports that these phenomena are functionally meaningful. In this work, the high sensitivity available at 7T was explored to map and characterize both positive (PBRs) and

  10. Shy and bold great tits (Parus major): body temperature and breath rate in response to handling stress

    NARCIS (Netherlands)

    Carere, C.; Van Oers, K.

    2004-01-01

    A standard handling protocol was used to test the hypothesis that boldness predicts stress responsiveness in body temperature and breath rate. Great tit (Parus major) nestlings were taken from the field, hand reared until independence, and their response to a novel object was assessed. At the age of

  11. Shy and bold great tits (Parus major) : body temperature and breath rate in response to handling stress

    NARCIS (Netherlands)

    Carere, C; van Oers, K

    2004-01-01

    A standard handling protocol was used to test the hypothesis that boldness predicts stress responsiveness in body temperature and breath rate. Great tit (Parus major) nestlings were taken from the field, hand reared until independence, and their response to a novel object was assessed. At the age of

  12. Comparison between subjects with long- and short-allele carriers in the BOLD signal within amygdala during emotional tasks

    Science.gov (United States)

    Hadi, Shamil; Siadat, Mohamad R.; Babajani-Feremi, Abbas

    2012-03-01

    Emotional tasks may result in a strong blood oxygen level-dependent (BOLD) signal in the amygdala in 5- HTTLRP short-allele. Reduced anterior cingulate cortex (ACC)-amygdala connectivity in short-allele provides a potential mechanistic account for the observed increase in amygdala activity. In our study, fearful and threatening facial expressions were presented to two groups of 12 subjects with long- and short-allele carriers. The BOLD signals of the left amygdala of each group were averaged to increase the signal-to-noise ratio. A Bayesian approach was used to estimate the model parameters to elucidate the underlying hemodynamic mechanism. Our results showed a positive BOLD signal in the left amygdala for short-allele individuals, and a negative BOLD signal in the same region for long-allele individuals. This is due to the fact that short-allele is associated with lower availability of serotonin transporter (5-HTT) and this leads to an increase of serotonin (5-HT) concentration in the cACC-amygdala synapse.

  13. Associations of resting-state fMRI functional connectivity with flow-BOLD coupling and regional vasculature.

    Science.gov (United States)

    Tak, Sungho; Polimeni, Jonathan R; Wang, Danny J J; Yan, Lirong; Chen, J Jean

    2015-04-01

    There has been tremendous interest in applying functional magnetic resonance imaging-based resting-state functional connectivity (rs-fcMRI) measurements to the study of brain function. However, a lack of understanding of the physiological mechanisms of rs-fcMRI limits their ability to interpret rs-fcMRI findings. In this work, the authors examine the regional associations between rs-fcMRI estimates and dynamic coupling between the blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF), as well as resting macrovascular volume. Resting-state BOLD and CBF data were simultaneously acquired using a dual-echo pseudocontinuous arterial spin labeling (pCASL) technique, whereas macrovascular volume fraction was estimated using time-of-flight MR angiography. Functional connectivity within well-known functional networks—including the default mode, frontoparietal, and primary sensory-motor networks—was calculated using a conventional seed-based correlation approach. They found the functional connectivity strength to be significantly correlated with the regional increase in CBF-BOLD coupling strength and inversely proportional to macrovascular volume fraction. These relationships were consistently observed within all functional networks considered. Their findings suggest that highly connected networks observed using rs-fcMRI are not likely to be mediated by common vascular drainage linking distal cortical areas. Instead, high BOLD functional connectivity is more likely to reflect tighter neurovascular connections, attributable to neuronal pathways.

  14. Somatosensory BOLD fMRI reveals close link between salient blood pressure changes and the murine neuromatrix.

    Science.gov (United States)

    Reimann, Henning Matthias; Todiras, Mihail; Hodge, Russ; Huelnhagen, Till; Millward, Jason Michael; Turner, Robert; Seeliger, Erdmann; Bader, Michael; Pohlmann, Andreas; Niendorf, Thoralf

    2018-05-15

    The neuromatrix, or "pain matrix", is a network of cortical brain areas which is activated by noxious as well as salient somatosensory stimulation. This has been studied in mice and humans using blood oxygenation level-dependent (BOLD) fMRI. Here we demonstrate that BOLD effects observed in the murine neuromatrix in response to salient somatosensory stimuli are prone to reflect mean arterial blood pressure (MABP) changes, rather than neural activity. We show that a standard electrostimulus typically used in murine somatosensory fMRI can induce substantial elevations in MABP. Equivalent drug-induced MABP changes - without somatosensory stimulation - evoked BOLD patterns in the neuromatrix strikingly similar to those evoked by electrostimulation. This constitutes a serious caveat for murine fMRI. The regional specificity of these BOLD patterns can be attributed to the co-localization of the neuromatrix with large draining veins. Based on these findings we propose a cardiovascular support mechanism whereby abrupt elevations in MABP provide additional energy supply to the neuromatrix and other essential brain areas in fight-or-flight situations. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.

    Science.gov (United States)

    Yuan, Kai; Jin, Chenwang; Cheng, Ping; Yang, Xuejuan; Dong, Tao; Bi, Yanzhi; Xing, Lihong; von Deneen, Karen M; Yu, Dahua; Liu, Junyu; Liang, Jun; Cheng, Tingting; Qin, Wei; Tian, Jie

    2013-01-01

    The majority of previous neuroimaging studies have demonstrated both structural and task-related functional abnormalities in adolescents with online gaming addiction (OGA). However, few functional magnetic resonance imaging (fMRI) studies focused on the regional intensity of spontaneous fluctuations in blood oxygen level-dependent (BOLD) during the resting state and fewer studies investigated the relationship between the abnormal resting-state properties and the impaired cognitive control ability. In the present study, we employed the amplitude of low frequency fluctuation (ALFF) method to explore the local features of spontaneous brain activity in adolescents with OGA and healthy controls during resting-state. Eighteen adolescents with OGA and 18 age-, education- and gender-matched healthy volunteers participated in this study. Compared with healthy controls, adolescents with OGA showed a significant increase in ALFF values in the left medial orbitofrontal cortex (OFC), the left precuneus, the left supplementary motor area (SMA), the right parahippocampal gyrus (PHG) and the bilateral middle cingulate cortex (MCC). The abnormalities of these regions were also detected in previous addiction studies. More importantly, we found that ALFF values of the left medial OFC and left precuneus were positively correlated with the duration of OGA in adolescents with OGA. The ALFF values of the left medial OFC were also correlated with the color-word Stroop test performance. Our results suggested that the abnormal spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology of OGA.

  16. Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.

    Directory of Open Access Journals (Sweden)

    Kai Yuan

    Full Text Available The majority of previous neuroimaging studies have demonstrated both structural and task-related functional abnormalities in adolescents with online gaming addiction (OGA. However, few functional magnetic resonance imaging (fMRI studies focused on the regional intensity of spontaneous fluctuations in blood oxygen level-dependent (BOLD during the resting state and fewer studies investigated the relationship between the abnormal resting-state properties and the impaired cognitive control ability. In the present study, we employed the amplitude of low frequency fluctuation (ALFF method to explore the local features of spontaneous brain activity in adolescents with OGA and healthy controls during resting-state. Eighteen adolescents with OGA and 18 age-, education- and gender-matched healthy volunteers participated in this study. Compared with healthy controls, adolescents with OGA showed a significant increase in ALFF values in the left medial orbitofrontal cortex (OFC, the left precuneus, the left supplementary motor area (SMA, the right parahippocampal gyrus (PHG and the bilateral middle cingulate cortex (MCC. The abnormalities of these regions were also detected in previous addiction studies. More importantly, we found that ALFF values of the left medial OFC and left precuneus were positively correlated with the duration of OGA in adolescents with OGA. The ALFF values of the left medial OFC were also correlated with the color-word Stroop test performance. Our results suggested that the abnormal spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology of OGA.

  17. On Maximum Entropy and Inference

    Directory of Open Access Journals (Sweden)

    Luigi Gresele

    2017-11-01

    Full Text Available Maximum entropy is a powerful concept that entails a sharp separation between relevant and irrelevant variables. It is typically invoked in inference, once an assumption is made on what the relevant variables are, in order to estimate a model from data, that affords predictions on all other (dependent variables. Conversely, maximum entropy can be invoked to retrieve the relevant variables (sufficient statistics directly from the data, once a model is identified by Bayesian model selection. We explore this approach in the case of spin models with interactions of arbitrary order, and we discuss how relevant interactions can be inferred. In this perspective, the dimensionality of the inference problem is not set by the number of parameters in the model, but by the frequency distribution of the data. We illustrate the method showing its ability to recover the correct model in a few prototype cases and discuss its application on a real dataset.

  18. Maximum Water Hammer Sensitivity Analysis

    OpenAIRE

    Jalil Emadi; Abbas Solemani

    2011-01-01

    Pressure waves and Water Hammer occur in a pumping system when valves are closed or opened suddenly or in the case of sudden failure of pumps. Determination of maximum water hammer is considered one of the most important technical and economical items of which engineers and designers of pumping stations and conveyance pipelines should take care. Hammer Software is a recent application used to simulate water hammer. The present study focuses on determining significance of ...

  19. Maximum Gene-Support Tree

    Directory of Open Access Journals (Sweden)

    Yunfeng Shan

    2008-01-01

    Full Text Available Genomes and genes diversify during evolution; however, it is unclear to what extent genes still retain the relationship among species. Model species for molecular phylogenetic studies include yeasts and viruses whose genomes were sequenced as well as plants that have the fossil-supported true phylogenetic trees available. In this study, we generated single gene trees of seven yeast species as well as single gene trees of nine baculovirus species using all the orthologous genes among the species compared. Homologous genes among seven known plants were used for validation of the finding. Four algorithms—maximum parsimony (MP, minimum evolution (ME, maximum likelihood (ML, and neighbor-joining (NJ—were used. Trees were reconstructed before and after weighting the DNA and protein sequence lengths among genes. Rarely a gene can always generate the “true tree” by all the four algorithms. However, the most frequent gene tree, termed “maximum gene-support tree” (MGS tree, or WMGS tree for the weighted one, in yeasts, baculoviruses, or plants was consistently found to be the “true tree” among the species. The results provide insights into the overall degree of divergence of orthologous genes of the genomes analyzed and suggest the following: 1 The true tree relationship among the species studied is still maintained by the largest group of orthologous genes; 2 There are usually more orthologous genes with higher similarities between genetically closer species than between genetically more distant ones; and 3 The maximum gene-support tree reflects the phylogenetic relationship among species in comparison.

  20. Cascaded Amplitude Modulations in Sound Texture Perception

    DEFF Research Database (Denmark)

    McWalter, Richard Ian; Dau, Torsten

    2017-01-01

    . In this study, we investigated the perception of sound textures that contain rhythmic structure, specifically second-order amplitude modulations that arise from the interaction of different modulation rates, previously described as "beating" in the envelope-frequency domain. We developed an auditory texture...... model that utilizes a cascade of modulation filterbanks that capture the structure of simple rhythmic patterns. The model was examined in a series of psychophysical listening experiments using synthetic sound textures-stimuli generated using time-averaged statistics measured from real-world textures....... In a texture identification task, our results indicated that second-order amplitude modulation sensitivity enhanced recognition. Next, we examined the contribution of the second-order modulation analysis in a preference task, where the proposed auditory texture model was preferred over a range of model...

  1. Source amplitudes for active exterior cloaking

    International Nuclear Information System (INIS)

    Norris, Andrew N; Amirkulova, Feruza A; Parnell, William J

    2012-01-01

    The active cloak comprises a discrete set of multipole sources that destructively interfere with an incident time harmonic scalar wave to produce zero total field over a finite spatial region. For a given number of sources and their positions in two dimensions it is shown that the multipole amplitudes can be expressed as infinite sums of the coefficients of the incident wave decomposed into regular Bessel functions. The field generated by the active sources vanishes in the infinite region exterior to a set of circles defined by the relative positions of the sources. The results provide a direct solution to the inverse problem of determining the source amplitudes. They also define a broad class of non-radiating discrete sources. (paper)

  2. Constructing QCD one-loop amplitudes

    International Nuclear Information System (INIS)

    Forde, D

    2008-01-01

    In the context of constructing one-loop amplitudes using a unitarity bootstrap approach we discuss a general systematic procedure for obtaining the coefficients of the scalar bubble and triangle integral functions of one-loop amplitudes. Coefficients are extracted after examining the behavior of the cut integrand as the unconstrained parameters of a specifically chosen parameterization of the cut loop momentum approach infinity. Measurements of new physics at the forthcoming experimental program at CERN's Large Hadron Collider (LHC) will require a precise understanding of processes at next-to-leading order (NLO). This places increased demands for the computation of new one-loop amplitudes. This in turn has spurred recent developments towards improved calculational techniques. Direct calculations using Feynman diagrams are in general inefficient. Developments of more efficient techniques have usually centered around unitarity techniques [1], where tree amplitudes are effectively 'glued' together to form loops. The most straightforward application of this method, in which the cut loop momentum is in D = 4, allows for the computation of 'cut-constructible' terms only, i.e. (poly)logarithmic containing terms and any related constants. QCD amplitudes contain, in addition to such terms, rational pieces which cannot be derived using such cuts. These 'missing' rational parts can be extracted using cut loop momenta in D = 4-2 (var e psilon). The greater difficulty of such calculations has restricted the application of this approach, although recent developments [3, 4] have provided new promise for this technique. Recently the application of on-shell recursion relations [5] to obtaining the 'missing' rational parts of one-loop processes [6] has provided an alternative very promising solution to this problem. In combination with unitarity methods an 'on-shell bootstrap' approach provides an efficient technique for computing complete one-loop QCD amplitudes [7]. Additionally

  3. Differential equations, associators, and recurrences for amplitudes

    Directory of Open Access Journals (Sweden)

    Georg Puhlfürst

    2016-01-01

    Full Text Available We provide new methods to straightforwardly obtain compact and analytic expressions for ϵ-expansions of functions appearing in both field and string theory amplitudes. An algebraic method is presented to explicitly solve for recurrence relations connecting different ϵ-orders of a power series solution in ϵ of a differential equation. This strategy generalizes the usual iteration by Picard's method. Our tools are demonstrated for generalized hypergeometric functions. Furthermore, we match the ϵ-expansion of specific generalized hypergeometric functions with the underlying Drinfeld associator with proper Lie algebra and monodromy representations. We also apply our tools for computing ϵ-expansions for solutions to generic first-order Fuchsian equations (Schlesinger system. Finally, we set up our methods to systematically get compact and explicit α′-expansions of tree-level superstring amplitudes to any order in α′.

  4. Unitarity and amplitudes for high energies

    International Nuclear Information System (INIS)

    Efimov, G.V.

    1997-01-01

    It is shown that in the quantum field theory of scalar particles with mass m the following inequalities for the upper bound for the amplitude of elastic scattering Μ(s,t) |Μ(s,t)| 0 )s, (|t|≥|t 0 |>0) and for the total cross section of scalar particles σ tot (s)≤C|d/dt ln Im Μ(s,t)| t=0 , (s → ∞) are valid. This result is based on the unitarity of the S-matrix on the mass shell and on a natural assumption that the imaginary part of the elastic scattering Im Μ(s,t) is a differentiable and convex down function in some vicinity of t=0. The locality of the theory and the analyticity of the elastic amplitude in the Martin-Lehmann ellipse are not used in proving these inequalities

  5. Large amplitude waves and fields in plasmas

    International Nuclear Information System (INIS)

    Angelis, U. de; Naples Univ.

    1990-02-01

    In this review, based mostly on the results of the recent workshop on ''Large Amplitude Waves and Fields in Plasmas'' held at ICTP (Trieste, Italy) in May 1989 during the Spring College on Plasma Physics, I will mostly concentrate on underdense, cold, homogeneous plasmas, discussing some of the alternative (to fusion) uses of laser-plasma interaction. In Part I an outline of some basic non-linear processes is given, together with some recent experimental results. The processes are chosen because of their relevance to the applications or because new interesting developments have been reported at the ICTP workshop (or both). In Part II the excitation mechanisms and uses of large amplitude plasma waves are presented: these include phase-conjugation in plasmas, plasma based accelerators (beat-wave, plasma wake-field and laser wake-field), plasma lenses and plasma wigglers for Free Electron Lasers. (author)

  6. Integrable spin chains and scattering amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Bartels, J.; Prygarin, A. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Lipatov, L.N. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Petersburg Nuclear Physics Institute (Russian Federation); Sankt-Peterburgskij Univ., St. Petersburg (Russian Federation)

    2011-04-15

    In this review we show that the multi-particle scattering amplitudes in N=4 SYM at large N{sub c} and in the multi-Regge kinematics for some physical regions have the high energy behavior appearing from the contribution of the Mandelstam cuts in the complex angular momentum plane of the corresponding t-channel partial waves. These Mandelstam cuts or Regge cuts are resulting from gluon composite states in the adjoint representation of the gauge group SU(N{sub c}). In the leading logarithmic approximation (LLA) their contribution to the six point amplitude is in full agreement with the known two-loop result. The Hamiltonian for the Mandelstam states constructed from n gluons in LLA coincides with the local Hamiltonian of an integrable open spin chain. We construct the corresponding wave functions using the integrals of motion and the Baxter-Sklyanin approach. (orig.)

  7. Spatiotemporal dynamics of the brain at rest--exploring EEG microstates as electrophysiological signatures of BOLD resting state networks.

    Science.gov (United States)

    Yuan, Han; Zotev, Vadim; Phillips, Raquel; Drevets, Wayne C; Bodurka, Jerzy

    2012-05-01

    Neuroimaging research suggests that the resting cerebral physiology is characterized by complex patterns of neuronal activity in widely distributed functional networks. As studied using functional magnetic resonance imaging (fMRI) of the blood-oxygenation-level dependent (BOLD) signal, the resting brain activity is associated with slowly fluctuating hemodynamic signals (~10s). More recently, multimodal functional imaging studies involving simultaneous acquisition of BOLD-fMRI and electroencephalography (EEG) data have suggested that the relatively slow hemodynamic fluctuations of some resting state networks (RSNs) evinced in the BOLD data are related to much faster (~100 ms) transient brain states reflected in EEG signals, that are referred to as "microstates". To further elucidate the relationship between microstates and RSNs, we developed a fully data-driven approach that combines information from simultaneously recorded, high-density EEG and BOLD-fMRI data. Using independent component analysis (ICA) of the combined EEG and fMRI data, we identified thirteen microstates and ten RSNs that are organized independently in their temporal and spatial characteristics, respectively. We hypothesized that the intrinsic brain networks that are active at rest would be reflected in both the EEG data and the fMRI data. To test this hypothesis, the rapid fluctuations associated with each microstate were correlated with the BOLD-fMRI signal associated with each RSN. We found that each RSN was characterized further by a specific electrophysiological signature involving from one to a combination of several microstates. Moreover, by comparing the time course of EEG microstates to that of the whole-brain BOLD signal, on a multi-subject group level, we unraveled for the first time a set of microstate-associated networks that correspond to a range of previously described RSNs, including visual, sensorimotor, auditory, attention, frontal, visceromotor and default mode networks. These

  8. The impact of susceptibility gradients on cartesian and spiral EPI for BOLD fMRI

    DEFF Research Database (Denmark)

    Sangill, Ryan; Wallentin, Mikkel; Østergaard, Leif

    2006-01-01

    , with special emphasis on spiral EPI (spiral) and cartesian EPI (EPI) and their performance under influence of induced field gradients (SFGs) and stochastic noise. A numerical method for calculating synthetic MR images is developed and used to simulate BOLD fMRI experiments using EPI and spirals. The data...... is then examined for activation using a pixel-wise t test. Nine subjects are scanned with both techniques while performing a motor task. SPM99 is used for analysing the experimental data. The simulated spirals provide generally higher t scores at low SFGs but lose more strength than EPI at higher SFGs, where EPI...... activation is offset from the true position. In the primary motor area spirals provide significantly higher t scores (P SFG areas spirals provide stronger activation than...

  9. LCLS Maximum Credible Beam Power

    International Nuclear Information System (INIS)

    Clendenin, J.

    2005-01-01

    The maximum credible beam power is defined as the highest credible average beam power that the accelerator can deliver to the point in question, given the laws of physics, the beam line design, and assuming all protection devices have failed. For a new accelerator project, the official maximum credible beam power is determined by project staff in consultation with the Radiation Physics Department, after examining the arguments and evidence presented by the appropriate accelerator physicist(s) and beam line engineers. The definitive parameter becomes part of the project's safety envelope. This technical note will first review the studies that were done for the Gun Test Facility (GTF) at SSRL, where a photoinjector similar to the one proposed for the LCLS is being tested. In Section 3 the maximum charge out of the gun for a single rf pulse is calculated. In Section 4, PARMELA simulations are used to track the beam from the gun to the end of the photoinjector. Finally in Section 5 the beam through the matching section and injected into Linac-1 is discussed

  10. Understanding the amplitudes of noise correlation measurements

    Science.gov (United States)

    Tsai, Victor C.

    2011-01-01

    Cross correlation of ambient seismic noise is known to result in time series from which station-station travel-time measurements can be made. Part of the reason that these cross-correlation travel-time measurements are reliable is that there exists a theoretical framework that quantifies how these travel times depend on the features of the ambient noise. However, corresponding theoretical results do not currently exist to describe how the amplitudes of the cross correlation depend on such features. For example, currently it is not possible to take a given distribution of noise sources and calculate the cross correlation amplitudes one would expect from such a distribution. Here, we provide a ray-theoretical framework for calculating cross correlations. This framework differs from previous work in that it explicitly accounts for attenuation as well as the spatial distribution of sources and therefore can address the issue of quantifying amplitudes in noise correlation measurements. After introducing the general framework, we apply it to two specific problems. First, we show that we can quantify the amplitudes of coherency measurements, and find that the decay of coherency with station-station spacing depends crucially on the distribution of noise sources. We suggest that researchers interested in performing attenuation measurements from noise coherency should first determine how the dominant sources of noise are distributed. Second, we show that we can quantify the signal-to-noise ratio of noise correlations more precisely than previous work, and that these signal-to-noise ratios can be estimated for given situations prior to the deployment of seismometers. It is expected that there are applications of the theoretical framework beyond the two specific cases considered, but these applications await future work.

  11. On the infinities of closed superstring amplitudes

    International Nuclear Information System (INIS)

    Restuccia, A.; Taylor, J.G.

    1988-01-01

    The authors present an analysis of possible infinities that may be present in uncompactified multi-loop heterotic and type II superstring amplitudes constructed, without use of the short-string limit, in the light-cone gauge, and with use of a closed [10]-SUSY field theory algebra. Various types of degenerations of the integrand are discussed on the string worldsheet. No infinities are found, modulo (for type II) a particular identity for Green's functions

  12. Deep Inelastic Scattering at the Amplitude Level

    International Nuclear Information System (INIS)

    Brodsky, Stanley J.

    2005-01-01

    The deep inelastic lepton scattering and deeply virtual Compton scattering cross sections can be interpreted in terms of the fundamental wavefunctions defined by the light-front Fock expansion, thus allowing tests of QCD at the amplitude level. The AdS/CFT correspondence between gauge theory and string theory provides remarkable new insights into QCD, including a model for hadronic wavefunctions which display conformal scaling at short distances and color confinement at large distances

  13. Multichannel conformal blocks for scattering amplitudes

    Science.gov (United States)

    Belitsky, A. V.

    2018-05-01

    By performing resummation of small fermion-antifermion pairs within the pentagon form factor program to scattering amplitudes in planar N = 4 superYang-Mills theory, we construct multichannel conformal blocks within the flux-tube picture for N-sided NMHV polygons. This procedure is equivalent to summation of descendants of conformal primaries in the OPE framework. The resulting conformal partial waves are determined by multivariable hypergeometric series of Lauricella-Saran type.

  14. How to calculate the Coulomb scattering amplitude

    International Nuclear Information System (INIS)

    Grosse, H.; Narnhofer, H.; Thirring, W.

    1974-01-01

    The derivation of scattering amplitudes for Coulomb scattering is discussed. A derivation of the S-matrix elements for a dense set of states in momentum space is given in the framework of time dependent scattering theory. The convergence of the S-matrix is studied. A purely algebraic derivation of the S-matrix elements and phase shifts is also presented. (HFdV)

  15. Spatial-temporal-spectral EEG patterns of BOLD functional network connectivity dynamics

    Science.gov (United States)

    Lamoš, Martin; Mareček, Radek; Slavíček, Tomáš; Mikl, Michal; Rektor, Ivan; Jan, Jiří

    2018-06-01

    Objective. Growing interest in the examination of large-scale brain network functional connectivity dynamics is accompanied by an effort to find the electrophysiological correlates. The commonly used constraints applied to spatial and spectral domains during electroencephalogram (EEG) data analysis may leave part of the neural activity unrecognized. We propose an approach that blindly reveals multimodal EEG spectral patterns that are related to the dynamics of the BOLD functional network connectivity. Approach. The blind decomposition of EEG spectrogram by parallel factor analysis has been shown to be a useful technique for uncovering patterns of neural activity. The simultaneously acquired BOLD fMRI data were decomposed by independent component analysis. Dynamic functional connectivity was computed on the component’s time series using a sliding window correlation, and between-network connectivity states were then defined based on the values of the correlation coefficients. ANOVA tests were performed to assess the relationships between the dynamics of between-network connectivity states and the fluctuations of EEG spectral patterns. Main results. We found three patterns related to the dynamics of between-network connectivity states. The first pattern has dominant peaks in the alpha, beta, and gamma bands and is related to the dynamics between the auditory, sensorimotor, and attentional networks. The second pattern, with dominant peaks in the theta and low alpha bands, is related to the visual and default mode network. The third pattern, also with peaks in the theta and low alpha bands, is related to the auditory and frontal network. Significance. Our previous findings revealed a relationship between EEG spectral pattern fluctuations and the hemodynamics of large-scale brain networks. In this study, we suggest that the relationship also exists at the level of functional connectivity dynamics among large-scale brain networks when no standard spatial and spectral

  16. A statistical approach for segregating cognitive task stages from multivariate fMRI BOLD time series

    Directory of Open Access Journals (Sweden)

    Charmaine eDemanuele

    2015-10-01

    Full Text Available Multivariate pattern analysis can reveal new information from neuroimaging data to illuminate human cognition and its disturbances. Here, we develop a methodological approach, based on multivariate statistical/machine learning and time series analysis, to discern cognitive processing stages from fMRI blood oxygenation level dependent (BOLD time series. We apply this method to data recorded from a group of healthy adults whilst performing a virtual reality version of the delayed win-shift radial arm maze task. This task has been frequently used to study working memory and decision making in rodents. Using linear classifiers and multivariate test statistics in conjunction with time series bootstraps, we show that different cognitive stages of the task, as defined by the experimenter, namely, the encoding/retrieval, choice, reward and delay stages, can be statistically discriminated from the BOLD time series in brain areas relevant for decision making and working memory. Discrimination of these task stages was significantly reduced during poor behavioral performance in dorsolateral prefrontal cortex (DLPFC, but not in the primary visual cortex (V1. Experimenter-defined dissection of time series into class labels based on task structure was confirmed by an unsupervised, bottom-up approach based on Hidden Markov Models. Furthermore, we show that different groupings of recorded time points into cognitive event classes can be used to test hypotheses about the specific cognitive role of a given brain region during task execution. We found that whilst the DLPFC strongly differentiated between task stages associated with different memory loads, but not between different visual-spatial aspects, the reverse was true for V1. Our methodology illustrates how different aspects of cognitive information processing during one and the same task can be separated and attributed to specific brain regions based on information contained in multivariate patterns of voxel

  17. Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention

    Directory of Open Access Journals (Sweden)

    Mara eKottlow

    2015-05-01

    Full Text Available Working memory (WM processes depend on our momentary mental state and therefore exhibit considerable fluctuations. Here, we investigate the interplay of task-preparatory and task-related brain activity as represented by pre-stimulus BOLD-fluctuations and spectral EEG from the retention periods of a visual WM task. Visual WM is used to maintain sensory information in the brain enabling the performance of cognitive operations and is associated with mental health.We tested 22 subjects simultaneously with EEG and fMRI while performing a visuo-verbal Sternberg task with two different loads, allowing for the temporal separation of preparation, encoding, retention and retrieval periods.Four temporally coherent networks - the default mode network (DMN, the dorsal attention, the right and the left WM network - were extracted from the continuous BOLD data by means of a group ICA. Subsequently, the modulatory effect of these networks’ pre-stimulus activation upon retention-related EEG activity in the theta, alpha and beta frequencies was analyzed. The obtained results are informative in the context of state-dependent information processing.We were able to replicate two well-known load-dependent effects: the frontal-midline theta increase during the task and the decrease of pre-stimulus DMN activity. As our main finding, these two measures seem to depend on each other as the significant negative correlations at frontal-midline channels suggested. Thus, suppressed pre-stimulus DMN levels facilitated later task related frontal midline theta increases. In general, based on previous findings that neuronal coupling in different frequency bands may underlie distinct functions in WM retention, our results suggest that processes reflected by spectral oscillations during retention seem not only to be online synchronized with activity in different attention-related networks but are also modulated by activity in these networks during preparation intervals.

  18. Frequency-dependent tACS modulation of BOLD signal during rhythmic visual stimulation.

    Science.gov (United States)

    Chai, Yuhui; Sheng, Jingwei; Bandettini, Peter A; Gao, Jia-Hong

    2018-05-01

    Transcranial alternating current stimulation (tACS) has emerged as a promising tool for modulating cortical oscillations. In previous electroencephalogram (EEG) studies, tACS has been found to modulate brain oscillatory activity in a frequency-specific manner. However, the spatial distribution and hemodynamic response for this modulation remains poorly understood. Functional magnetic resonance imaging (fMRI) has the advantage of measuring neuronal activity in regions not only below the tACS electrodes but also across the whole brain with high spatial resolution. Here, we measured fMRI signal while applying tACS to modulate rhythmic visual activity. During fMRI acquisition, tACS at different frequencies (4, 8, 16, and 32 Hz) was applied along with visual flicker stimulation at 8 and 16 Hz. We analyzed the blood-oxygen-level-dependent (BOLD) signal difference between tACS-ON vs tACS-OFF, and different frequency combinations (e.g., 4 Hz tACS, 8 Hz flicker vs 8 Hz tACS, 8 Hz flicker). We observed significant tACS modulation effects on BOLD responses when the tACS frequency matched the visual flicker frequency or the second harmonic frequency. The main effects were predominantly seen in regions that were activated by the visual task and targeted by the tACS current distribution. These findings bridge different scientific domains of tACS research and demonstrate that fMRI could localize the tACS effect on stimulus-induced brain rhythms, which could lead to a new approach for understanding the high-level cognitive process shaped by the ongoing oscillatory signal. © 2018 Wiley Periodicals, Inc.

  19. Computing moment to moment BOLD activation for real-time neurofeedback

    Science.gov (United States)

    Hinds, Oliver; Ghosh, Satrajit; Thompson, Todd W.; Yoo, Julie J.; Whitfield-Gabrieli, Susan; Triantafyllou, Christina; Gabrieli, John D.E.

    2013-01-01

    Estimating moment to moment changes in blood oxygenation level dependent (BOLD) activation levels from functional magnetic resonance imaging (fMRI) data has applications for learned regulation of regional activation, brain state monitoring, and brain-machine interfaces. In each of these contexts, accurate estimation of the BOLD signal in as little time as possible is desired. This is a challenging problem due to the low signal-to-noise ratio of fMRI data. Previous methods for real-time fMRI analysis have either sacrificed the ability to compute moment to moment activation changes by averaging several acquisitions into a single activation estimate or have sacrificed accuracy by failing to account for prominent sources of noise in the fMRI signal. Here we present a new method for computing the amount of activation present in a single fMRI acquisition that separates moment to moment changes in the fMRI signal intensity attributable to neural sources from those due to noise, resulting in a feedback signal more reflective of neural activation. This method computes an incremental general linear model fit to the fMRI timeseries, which is used to calculate the expected signal intensity at each new acquisition. The difference between the measured intensity and the expected intensity is scaled by the variance of the estimator in order to transform this residual difference into a statistic. Both synthetic and real data were used to validate this method and compare it to the only other published real-time fMRI method. PMID:20682350

  20. Back pain in seniors: the Back pain Outcomes using Longitudinal Data (BOLD) cohort baseline data.

    Science.gov (United States)

    Jarvik, Jeffrey G; Comstock, Bryan A; Heagerty, Patrick J; Turner, Judith A; Sullivan, Sean D; Shi, Xu; Nerenz, David R; Nedeljkovic, Srdjan S; Kessler, Larry; James, Kathryn; Friedly, Janna L; Bresnahan, Brian W; Bauer, Zoya; Avins, Andrew L; Deyo, Richard A

    2014-04-23

    Back pain represents a substantial burden globally, ranking first in a recent assessment among causes of years lived with disability. Though back pain is widely studied among working age adults, there are gaps with respect to basic descriptive epidemiology among seniors, especially in the United States. Our goal was to describe how pain, function and health-related quality of life vary by demographic and geographic factors among seniors presenting to primary care providers with new episodes of care for back pain. We examined baseline data from the Back pain Outcomes using Longitudinal Data (BOLD) registry, the largest inception cohort to date of seniors presenting to a primary care provider for back pain. The sample included 5,239 patients ≥ 65 years old with a new primary care visit for back pain at three integrated health systems (Northern California Kaiser-Permanente, Henry Ford Health System [Detroit], and Harvard Vanguard Medical Associates [Boston]). We examined differences in patient characteristics across healthcare sites and associations of patient sociodemographic and clinical characteristics with baseline patient-reported measures of pain, function, and health-related quality of life. Patients differed across sites in demographic and other characteristics. The Detroit site had more African-American patients (50%) compared with the other sites (7-8%). The Boston site had more college graduates (68%) compared with Detroit (20%). Female sex, lower educational status, African-American race, and older age were associated with worse functional disability as measured by the Roland-Morris Disability Questionnaire. Except for age, these factors were also associated with worse pain. Baseline pain and functional impairment varied substantially with a number of factors in the BOLD cohort. Healthcare site was an important factor. After controlling for healthcare site, lower education, female sex, African-American race, and older age were associated with worse

  1. Consistency in boldness, activity and exploration at different stages of life

    Science.gov (United States)

    2013-01-01

    Background Animals show consistent individual behavioural patterns over time and over situations. This phenomenon has been referred to as animal personality or behavioural syndromes. Little is known about consistency of animal personalities over entire life times. We investigated the repeatability of behaviour in common voles (Microtus arvalis) at different life stages, with different time intervals, and in different situations. Animals were tested using four behavioural tests in three experimental groups: 1. before and after maturation over three months, 2. twice as adults during one week, and 3. twice as adult animals over three months, which resembles a substantial part of their entire adult life span of several months. Results Different behaviours were correlated within and between tests and a cluster analysis showed three possible behavioural syndrome-axes, which we name boldness, exploration and activity. Activity and exploration behaviour in all tests was highly repeatable in adult animals tested over one week. In animals tested over maturation, exploration behaviour was consistent whereas activity was not. Voles that were tested as adults with a three-month interval showed the opposite pattern with stable activity but unstable exploration behaviour. Conclusions The consistency in behaviour over time suggests that common voles do express stable personality over short time. Over longer periods however, behaviour is more flexible and depending on life stage (i.e. tested before/after maturation or as adults) of the tested individual. Level of boldness or activity does not differ between tested groups and maintenance of variation in behavioural traits can therefore not be explained by expected future assets as reported in other studies. PMID:24314274

  2. Interneuronal systems of the cervical spinal cord assessed with BOLD imaging at 1.5 T

    International Nuclear Information System (INIS)

    Stracke, C.P.; Schoth, F.; Moeller-Hartmann, W.; Krings, T.; Pettersson, L.G.

    2005-01-01

    The purpose of this study was to investigate if functional activity with spinal cord somatosensory stimulation can be visualized using BOLD fMRI. We investigated nine healthy volunteers using a somatosensory stimulus generator. The stimuli were applied in three different runs at the first, third, and fifth finger tip of the right hand, respectively, corresponding to dermatomes c6, c7, and c8. The stimuli gave an increase of BOLD signal (activation) in three different locations of the spinal cord and brain stem. First, activations could be seen in the spinal segment corresponding to the stimulated dermatome in seven out of nine volunteers for c6 stimulation, two out of eight for c7, and three out of eight for c8. These activations were located close to the posterior margin of the spinal cord, presumably reflecting synaptic transmission to dorsal horn interneurons. Second, activation in the medulla oblongata was evident in four subjects, most likely corresponding to the location of the nucleus cuneatus. The third location of activation, which was the strongest and most reliable observed was inside the spinal cord in the c3 and c4 segments. Activation at these spinal levels was almost invariably observed independently of the dermatome stimulated (9/9 for c6, 8/8 for c7, and 7/8 for c8 stimulation). These activations may pertain to an interneuronal system at this spinal level. The results are discussed in relation to neurophysiological studies on cervical spinal interneuronal pathways in animals and humans. (orig.)

  3. Negative BOLD in sensory cortices during verbal memory: a component in generating internal representations?

    Science.gov (United States)

    Azulay, Haim; Striem, Ella; Amedi, Amir

    2009-05-01

    People tend to close their eyes when trying to retrieve an event or a visual image from memory. However the brain mechanisms behind this phenomenon remain poorly understood. Recently, we showed that during visual mental imagery, auditory areas show a much more robust deactivation than during visual perception. Here we ask whether this is a special case of a more general phenomenon involving retrieval of intrinsic, internally stored information, which would result in crossmodal deactivations in other sensory cortices which are irrelevant to the task at hand. To test this hypothesis, a group of 9 sighted individuals were scanned while performing a memory retrieval task for highly abstract words (i.e., with low imaginability scores). We also scanned a group of 10 congenitally blind, which by definition do not have any visual imagery per se. In sighted subjects, both auditory and visual areas were robustly deactivated during memory retrieval, whereas in the blind the auditory cortex was deactivated while visual areas, shown previously to be relevant for this task, presented a positive BOLD signal. These results suggest that deactivation may be most prominent in task-irrelevant sensory cortices whenever there is a need for retrieval or manipulation of internally stored representations. Thus, there is a task-dependent balance of activation and deactivation that might allow maximization of resources and filtering out of non relevant information to enable allocation of attention to the required task. Furthermore, these results suggest that the balance between positive and negative BOLD might be crucial to our understanding of a large variety of intrinsic and extrinsic tasks including high-level cognitive functions, sensory processing and multisensory integration.

  4. Boldness towards novelty and translocation success in captive-raised, orphaned Tasmanian devils.

    Science.gov (United States)

    Sinn, David L; Cawthen, Lisa; Jones, Susan M; Pukk, Chrissy; Jones, Menna E

    2014-01-01

    Translocation of endangered animals is common, but success is often variable and/or poor. Despite its intuitive appeal, little is known with regards to how individual differences amongst translocated animals influence their post-release survival, growth, and reproduction. We measured consistent pre-release responses to novelty in a familiar environment (boldness; repeatability=0.55) and cortisol response in a group of captive-reared Tasmanian devils, currently listed as "Endangered" by the IUCN. The devils were then released at either a hard- or soft-release site within their mothers' population of origin, and individual growth, movement, reproduction (females only), and survival across 2-8 months post-release was measured. Sex, release method, cohort, behavior, and cortisol response did not affect post-release growth, nor did these factors influence the home range size of orphan devils. Final linear distances moved from the release site were impacted heavily by the release cohort, but translocated devils' movement overall was not different from that in the same-age wild devils. All orphan females of reproductive age were subsequently captured with offspring. Overall survival rates in translocated devils were moderate (∼42%), and were not affected by devil sex, release method, cohort, release weight, or pre-release cortisol response. Devils that survived during the study period were, however, 3.5 times more bold than those that did not (effect size r=0.76). Our results suggest that conservation managers may need to provide developmental conditions in captivity that promote a wide range of behaviors across individuals slated for wild release. © 2013 Wiley Periodicals, Inc.

  5. Distributed BOLD-response in association cortex vector state space predicts reaction time during selective attention.

    Science.gov (United States)

    Musso, Francesco; Konrad, Andreas; Vucurevic, Goran; Schäffner, Cornelius; Friedrich, Britta; Frech, Peter; Stoeter, Peter; Winterer, Georg

    2006-02-15

    Human cortical information processing is thought to be dominated by distributed activity in vector state space (Churchland, P.S., Sejnowski, T.J., 1992. The Computational Brain. MIT Press, Cambridge.). In principle, it should be possible to quantify distributed brain activation with independent component analysis (ICA) through vector-based decomposition, i.e., through a separation of a mixture of sources. Using event-related functional magnetic resonance imaging (fMRI) during a selective attention-requiring task (visual oddball), we explored how the number of independent components within activated cortical areas is related to reaction time. Prior to ICA, the activated cortical areas were determined on the basis of a General linear model (GLM) voxel-by-voxel analysis of the target stimuli (checkerboard reversal). Two activated cortical areas (temporoparietal cortex, medial prefrontal cortex) were further investigated as these cortical regions are known to be the sites of simultaneously active electromagnetic generators which give rise to the compound event-related potential P300 during oddball task conditions. We found that the number of independent components more strongly predicted reaction time than the overall level of "activation" (GLM BOLD-response) in the left temporoparietal area whereas in the medial prefrontal cortex both ICA and GLM predicted reaction time equally well. Comparable correlations were not seen when principle components were used instead of independent components. These results indicate that the number of independently activated components, i.e., a high level of cortical activation complexity in cortical vector state space, may index particularly efficient information processing during selective attention-requiring tasks. To our best knowledge, this is the first report describing a potential relationship between neuronal generators of cognitive processes, the associated electrophysiological evidence for the existence of distributed networks

  6. Accommodative Amplitude in School-Age Children

    Directory of Open Access Journals (Sweden)

    Ikaunieks Gatis

    2017-10-01

    Full Text Available In children, intensive near-work affects the accommodation system of the eye. Younger children, due to anatomical parameters, read at smaller distance than older children and we can expect that the accommodation system of younger can be affected more than that of older children. We wanted to test this hypothesis. Some authors showed that the norms of amplitude of accommodation (AA developed by Hofstetter (1950 not always could be applied for children. We also wanted to verify these results. A total of 106 (age 7-15 children participated in the study. Distance visual acuity was measured for all children and only data of children with good visual acuity 1.0 or more (dec. units were analysed (73 children. Accommodative amplitude was measured before and after lessons using subjective push-up technique (with RAF Near Point Ruler. The results showed that the amplitude of accommodation reduced significantly (p < 0.05 during the day and decrease of AA was similar in different age groups (about ~0.70 D. Additional measurements are needed to verify that the observed changes in AA were associated with fatigue effect. The results showed lower accommodation values compared to average values calculated according to the Hofstetter equation (p < 0.05.

  7. Cascaded Amplitude Modulations in Sound Texture Perception

    Directory of Open Access Journals (Sweden)

    Richard McWalter

    2017-09-01

    Full Text Available Sound textures, such as crackling fire or chirping crickets, represent a broad class of sounds defined by their homogeneous temporal structure. It has been suggested that the perception of texture is mediated by time-averaged summary statistics measured from early auditory representations. In this study, we investigated the perception of sound textures that contain rhythmic structure, specifically second-order amplitude modulations that arise from the interaction of different modulation rates, previously described as “beating” in the envelope-frequency domain. We developed an auditory texture model that utilizes a cascade of modulation filterbanks that capture the structure of simple rhythmic patterns. The model was examined in a series of psychophysical listening experiments using synthetic sound textures—stimuli generated using time-averaged statistics measured from real-world textures. In a texture identification task, our results indicated that second-order amplitude modulation sensitivity enhanced recognition. Next, we examined the contribution of the second-order modulation analysis in a preference task, where the proposed auditory texture model was preferred over a range of model deviants that lacked second-order modulation rate sensitivity. Lastly, the discriminability of textures that included second-order amplitude modulations appeared to be perceived using a time-averaging process. Overall, our results demonstrate that the inclusion of second-order modulation analysis generates improvements in the perceived quality of synthetic textures compared to the first-order modulation analysis considered in previous approaches.

  8. Transversity Amplitudes in Hypercharge Exchange Processes

    International Nuclear Information System (INIS)

    Aguilar Benitez de Lugo, M.

    1979-01-01

    ' In this work we present several techniques developed for the extraction of the. Transversity amplitudes governing quasi two-body meson baryon reactions with hypercharge exchange. We review the methods used in processes having a pure spin configuration, as well as the more relevant results obtained with data from K p and Tp interactions at intermediate energies. The predictions of the additive quark model and the ones following from exchange degeneracy and etoxicity are discussed. We present a formalism for amplitude analysis developed for reactions with mixed spin configurations and discuss the methods of parametric estimation of the moduli and phases of the amplitudes, as well as the various tests employed to check the goodness of the fits. The calculation of the generalized joint density matrices is given and we propose a method based on the generalization of the idea of multipole moments, which allows to investigate the structure of the decay angular correlations and establishes the quality of the fits and the validity of the simplifying assumptions currently used in this type of studies. (Author) 43 refs

  9. Bayesian extraction of the parton distribution amplitude from the Bethe-Salpeter wave function

    Science.gov (United States)

    Gao, Fei; Chang, Lei; Liu, Yu-xin

    2017-07-01

    We propose a new numerical method to compute the parton distribution amplitude (PDA) from the Euclidean Bethe-Salpeter wave function. The essential step is to extract the weight function in the Nakanishi representation of the Bethe-Salpeter wave function in Euclidean space, which is an ill-posed inversion problem, via the maximum entropy method (MEM). The Nakanishi weight function as well as the corresponding light-front parton distribution amplitude (PDA) can be well determined. We confirm prior work on PDA computations, which was based on different methods.

  10. Bayesian extraction of the parton distribution amplitude from the Bethe–Salpeter wave function

    Directory of Open Access Journals (Sweden)

    Fei Gao

    2017-07-01

    Full Text Available We propose a new numerical method to compute the parton distribution amplitude (PDA from the Euclidean Bethe–Salpeter wave function. The essential step is to extract the weight function in the Nakanishi representation of the Bethe–Salpeter wave function in Euclidean space, which is an ill-posed inversion problem, via the maximum entropy method (MEM. The Nakanishi weight function as well as the corresponding light-front parton distribution amplitude (PDA can be well determined. We confirm prior work on PDA computations, which was based on different methods.

  11. Large amplitude ion-acoustic solitary waves and double layers in multicomponent plasma with positrons

    International Nuclear Information System (INIS)

    Sabry, R.

    2009-01-01

    A finite amplitude theory for ion-acoustic solitary waves and double layers in multicomponent plasma consisting of hot positrons, cold ions, and electrons with two-electron temperature distributions is presented. Conditions are obtained under which large amplitude stationary ion-acoustic solitary waves and double layers can exist. For the physical parameters of interest, the ion-acoustic solitary wave (double layers) profiles and the relationship between the maximum soliton (double layers) amplitude and the Mach number are found. Also, we have presented the region of existence of the large amplitude ion-acoustic waves by analyzing the structure of the pseudopotential. For the selected range of parameters, it is found that only positive solitary waves and double layers can exist. An analysis for the small amplitude limit through the Sagdeev pseudopotential analysis and the reductive perturbation theory shows the existence of positive and negative ion-acoustic solitary waves and double layers. The effects of positron concentration and temperature ratio on the characteristics of the solitary ion-acoustic waves and double layers (namely, the amplitude and width) are discussed in detail. The relevance of this investigation to space and laboratory plasmas is pointed out.

  12. Physiologic characterization of inflammatory arthritis in a rabbit model with BOLD and DCE MRI at 1.5 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Nasui, Otilia C.; Chan, Michael W.; Nathanael, George; Rayner, Tammy; Weiss, Ruth; Detzler, Garry; Zhong, Anguo [The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto, ON (Canada); Crawley, Adrian [University of Toronto, Department of Medical Imaging, Toronto, ON (Canada); Toronto Western Hospital, Department of Medical Imaging, Toronto, ON (Canada); Miller, Elka [Children' s Hospital of Eastern Ontario (CHEO), Department of Diagnostic Imaging, Ottawa, ON (Canada); Belik, Jaques [The Hospital for Sick Children, Department of Neonatology, Toronto, ON (Canada); Cheng, Hai-Ling; Kassner, Andrea; Doria, Andrea S. [The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto, ON (Canada); University of Toronto, Department of Medical Imaging, Toronto, ON (Canada); Moineddin, Rahim [Department of Public Health, Family and Community Medicine, Toronto, ON (Canada); Jong, Roland; Rogers, Marianne [Mount Sinai Hospital, Department of Pathology, Toronto, ON (Canada)

    2014-11-15

    Our aim was to test the feasibility of blood oxygen level dependent magnetic resonance imaging (BOLD MRI) and dynamic contrast-enhanced (DCE) MRI to monitor periarticular hypoxic/inflammatory changes over time in a juvenile rabbit model of arthritis. We examined arthritic and contralateral nonarthritic knees of 21 juvenile rabbits at baseline and days 1,14, and 28 after induction of arthritis by unilateral intra-articular injection of carrageenin with BOLD and DCE MRI at 1.5 Tesla (T). Nine noninjected rabbits served as controls. Associations between BOLD and DCE-MRI and corresponding intra-articular oxygen pressure (PO{sub 2}) and blood flow [blood perfusion units (BPU)] (polarographic probes, reference standards) or clinical-histological data were measured by correlation coefficients. Percentage BOLD MRI change obtained in contralateral knees correlated moderately with BPU on day 0 (r = -0.51, p = 0.02) and excellently on day 28 (r = -0.84, p = 0.03). A moderate correlation was observed between peak enhancement DCE MRI (day 1) and BPU measurements in arthritic knees (r = 0.49, p = 0.04). In acute arthritis, BOLD and DCE MRI highly correlated (r = 0.89, p = 0.04; r = 1.0, p < 0.0001) with histological scores in arthritic knees. The proposed techniques are feasible to perform at 1.5 T, and they hold potential as surrogate measures to monitor hypoxic and inflammatory changes over time in arthritis at higher-strength MRI fields. (orig.)

  13. Investigating the amplitude of interactive footstep sounds and soundscape reproduction

    DEFF Research Database (Denmark)

    Turchet, Luca; Serafin, Stefania

    2013-01-01

    In this paper, we study the perception of amplitude of soundscapes and interactively generated footstep sounds provided both through headphones and a surround sound system. In particular, we investigate whether there exists a value for the amplitude of soundscapes and footstep sounds which...... of soundscapes does not significantly affect the selected amplitude of footstep sounds. Similarly, the perception of the soundscapes amplitude is not significantly affected by the selected amplitude of footstep sounds....

  14. One-loop triple collinear splitting amplitudes in QCD

    Energy Technology Data Exchange (ETDEWEB)

    Badger, Simon; Buciuni, Francesco; Peraro, Tiziano [Higgs Centre for Theoretical Physics, School of Physics and Astronomy, University of Edinburgh,Edinburgh EH9 3JZ, Scotland (United Kingdom)

    2015-09-28

    We study the factorisation properties of one-loop scattering amplitudes in the triple collinear limit and extract the universal splitting amplitudes for processes initiated by a gluon. The splitting amplitudes are derived from the analytic Higgs plus four partons amplitudes. We present compact results for primitive helicity splitting amplitudes making use of super-symmetric decompositions. The universality of the collinear factorisation is checked numerically against the full colour six parton squared matrix elements.

  15. Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe.

    Science.gov (United States)

    Gagnon, Louis; Sakadžić, Sava; Lesage, Frédéric; Musacchia, Joseph J; Lefebvre, Joël; Fang, Qianqian; Yücel, Meryem A; Evans, Karleyton C; Mandeville, Emiri T; Cohen-Adad, Jülien; Polimeni, Jonathan R; Yaseen, Mohammad A; Lo, Eng H; Greve, Douglas N; Buxton, Richard B; Dale, Anders M; Devor, Anna; Boas, David A

    2015-02-25

    The blood oxygenation level-dependent (BOLD) contrast is widely used in functional magnetic resonance imaging (fMRI) studies aimed at investigating neuronal activity. However, the BOLD signal reflects changes in blood volume and oxygenation rather than neuronal activity per se. Therefore, understanding the transformation of microscopic vascular behavior into macroscopic BOLD signals is at the foundation of physiologically informed noninvasive neuroimaging. Here, we use oxygen-sensitive two-photon microscopy to measure the BOLD-relevant microvascular physiology occurring within a typical rodent fMRI voxel and predict the BOLD signal from first principles using those measurements. The predictive power of the approach is illustrated by quantifying variations in the BOLD signal induced by the morphological folding of the human cortex. This framework is then used to quantify the contribution of individual vascular compartments and other factors to the BOLD signal for different magnet strengths and pulse sequences. Copyright © 2015 the authors 0270-6474/15/353663-13$15.00/0.

  16. Generic maximum likely scale selection

    DEFF Research Database (Denmark)

    Pedersen, Kim Steenstrup; Loog, Marco; Markussen, Bo

    2007-01-01

    in this work is on applying this selection principle under a Brownian image model. This image model provides a simple scale invariant prior for natural images and we provide illustrative examples of the behavior of our scale estimation on such images. In these illustrative examples, estimation is based......The fundamental problem of local scale selection is addressed by means of a novel principle, which is based on maximum likelihood estimation. The principle is generally applicable to a broad variety of image models and descriptors, and provides a generic scale estimation methodology. The focus...

  17. Surface electromyographic amplitude does not identify differences in neural drive to synergistic muscles.

    Science.gov (United States)

    Martinez-Valdes, Eduardo; Negro, Francesco; Falla, Deborah; De Nunzio, Alessandro Marco; Farina, Dario

    2018-04-01

    Surface electromyographic (EMG) signal amplitude is typically used to compare the neural drive to muscles. We experimentally investigated this association by studying the motor unit (MU) behavior and action potentials in the vastus medialis (VM) and vastus lateralis (VL) muscles. Eighteen participants performed isometric knee extensions at four target torques [10, 30, 50, and 70% of the maximum torque (MVC)] while high-density EMG signals were recorded from the VM and VL. The absolute EMG amplitude was greater for VM than VL ( P differences in EMG amplitude can be due to both differences in the neural drive and in the size of the MU action potentials, we indirectly inferred the neural drives received by the two muscles by estimating the synaptic inputs received by the corresponding motor neuron pools. For this purpose, we analyzed the increase in discharge rate from recruitment to target torque for motor units matched by recruitment threshold in the two muscles. This analysis indicated that the two muscles received similar levels of neural drive. Nonetheless, the size of the MU action potentials was greater for VM than VL ( P difference explained most of the differences in EMG amplitude between the two muscles (~63% of explained variance). These results indicate that EMG amplitude, even following normalization, does not reflect the neural drive to synergistic muscles. Moreover, absolute EMG amplitude is mainly explained by the size of MU action potentials. NEW & NOTEWORTHY Electromyographic (EMG) amplitude is widely used to compare indirectly the strength of neural drive received by synergistic muscles. However, there are no studies validating this approach with motor unit data. Here, we compared between-muscles differences in surface EMG amplitude and motor unit behavior. The results clarify the limitations of surface EMG to interpret differences in neural drive between muscles.

  18. Influence of maximum bite force on jaw movement during gummy jelly mastication.

    Science.gov (United States)

    Kuninori, T; Tomonari, H; Uehara, S; Kitashima, F; Yagi, T; Miyawaki, S

    2014-05-01

    It is known that maximum bite force has various influences on chewing function; however, there have not been studies in which the relationships between maximum bite force and masticatory jaw movement have been clarified. The aim of this study was to investigate the effect of maximum bite force on masticatory jaw movement in subjects with normal occlusion. Thirty young adults (22 men and 8 women; mean age, 22.6 years) with good occlusion were divided into two groups based on whether they had a relatively high or low maximum bite force according to the median. The maximum bite force was determined according to the Dental Prescale System using pressure-sensitive sheets. Jaw movement during mastication of hard gummy jelly (each 5.5 g) on the preferred chewing side was recorded using a six degrees of freedom jaw movement recording system. The motion of the lower incisal point of the mandible was computed, and the mean values of 10 cycles (cycles 2-11) were calculated. A masticatory performance test was conducted using gummy jelly. Subjects with a lower maximum bite force showed increased maximum lateral amplitude, closing distance, width and closing angle; wider masticatory jaw movement; and significantly lower masticatory performance. However, no differences in the maximum vertical or maximum anteroposterior amplitudes were observed between the groups. Although other factors, such as individual morphology, may influence masticatory jaw movement, our results suggest that subjects with a lower maximum bite force show increased lateral jaw motion during mastication. © 2014 John Wiley & Sons Ltd.

  19. Post-contractile BOLD contrast in skeletal muscle at 7 T reveals inter-individual heterogeneity in the physiological responses to muscle contraction.

    Science.gov (United States)

    Towse, Theodore F; Elder, Christopher P; Bush, Emily C; Klockenkemper, Samuel W; Bullock, Jared T; Dortch, Richard D; Damon, Bruce M

    2016-12-01

    Muscle blood oxygenation-level dependent (BOLD) contrast is greater in magnitude and potentially more influenced by extravascular BOLD mechanisms at 7 T than it is at lower field strengths. Muscle BOLD imaging of muscle contractions at 7 T could, therefore, provide greater or different contrast than at 3 T. The purpose of this study was to evaluate the feasibility of using BOLD imaging at 7 T to assess the physiological responses to in vivo muscle contractions. Thirteen subjects (four females) performed a series of isometric contractions of the calf muscles while being scanned in a Philips Achieva 7 T human imager. Following 2 s maximal isometric plantarflexion contractions, BOLD signal transients ranging from 0.3 to 7.0% of the pre-contraction signal intensity were observed in the soleus muscle. We observed considerable inter-subject variability in both the magnitude and time course of the muscle BOLD signal. A subset of subjects (n = 7) repeated the contraction protocol at two different repetition times (T R : 1000 and 2500 ms) to determine the potential of T 1 -related inflow effects on the magnitude of the post-contractile BOLD response. Consistent with previous reports, there was no difference in the magnitude of the responses for the two T R values (3.8 ± 0.9 versus 4.0 ± 0.6% for T R  = 1000 and 2500 ms, respectively; mean ± standard error). These results demonstrate that studies of the muscle BOLD responses to contractions are feasible at 7 T. Compared with studies at lower field strengths, post-contractile 7 T muscle BOLD contrast may afford greater insight into microvascular function and dysfunction. Copyright © 2016 John Wiley & Sons, Ltd.

  20. Extreme Maximum Land Surface Temperatures.

    Science.gov (United States)

    Garratt, J. R.

    1992-09-01

    There are numerous reports in the literature of observations of land surface temperatures. Some of these, almost all made in situ, reveal maximum values in the 50°-70°C range, with a few, made in desert regions, near 80°C. Consideration of a simplified form of the surface energy balance equation, utilizing likely upper values of absorbed shortwave flux (1000 W m2) and screen air temperature (55°C), that surface temperatures in the vicinity of 90°-100°C may occur for dry, darkish soils of low thermal conductivity (0.1-0.2 W m1 K1). Numerical simulations confirm this and suggest that temperature gradients in the first few centimeters of soil may reach 0.5°-1°C mm1 under these extreme conditions. The study bears upon the intrinsic interest of identifying extreme maximum temperatures and yields interesting information regarding the comfort zone of animals (including man).

  1. Ethnic differences in electrocardiographic amplitude measurements

    International Nuclear Information System (INIS)

    Mansi, Ishak A.; Nash, Ira S.

    2004-01-01

    There is a controversy regarding ethnic differences in electrocardiographic (ECG) patterns because of the potentially confounding socioeconomic, nutritional, environmental and occupational factors. We reviewed the first 1000 medical files of a multiethnic community, where all individuals shared similar living conditions. Only healthy adults age 15 to 60 years were included. Wave amplitudes were measured manually from the standard 12lead ECG. Minnesota coding was used. ECG from 597 subjects were included in the study: 350 Saudi Arabians, 95 Indians, 17 Sri-Lankans, 39 Filipinos, and 57 Caucasians; 349 were men. the mean +-SD of Sokolow-Lyon voltage (SLV) in men was signifcantly different among ethnic groups (2.9+-0.86, 2.64+-0.79, 2.73+-0.72, 3.23+-0.61, 2.94+-0.6, 2.58+-0.79 mV, P=0.0006, for Saudi's, Indians, Jordanians, Filipinos, Sri-Lankans, and Caucasians, respectively). SLV was similar among ethnic groups in women. The prevalence of early transition pattern was also different among ethnic groups in men but not women (15.8%, 34.6%, 17.9%, 21.7%, 35.3%, 26.8% in Suadi, Indian, Jordanian, Filipino, Sri-Lankan, and Caucasian, respectively, P=0.037). T wave amplitude was significantly different among ethnic groups in selected lead. ECG wave amplitude differs with ethnic region even when other factors are similar. Using SLV of 3.5 mV as a criterion may overestimate the incidence of left ventricular hypertrophy in some ethnic groups. The pattern of high R wave in lead V1is common in healthy adults in certain ethnic groups. T wave height differs with ethnic origin and sex. (author)

  2. Co-localization between the BOLD response and epileptiform discharges recorded by simultaneous intracranial EEG-fMRI at 3 T

    Directory of Open Access Journals (Sweden)

    Yahya Aghakhani

    2015-01-01

    Conclusions: iEEG-fMRI is a feasible and low-risk method for assessment of hemodynamic changes of very focal IEDs that may not be recorded by scalp EEG. A high concordance rate between the location of the BOLD response and IEDs was seen for mesial temporal (6/7 IEDs. Significant BOLD activation was also seen in areas distant from the active electrode and these sites exhibited maximal BOLD activation in the majority of cases. This implies that iEEG-fMRI may further describe the areas involved in the generation of IEDs beyond the vicinity of the electrode(s.

  3. Loop amplitudes in an extended gravity theory

    Science.gov (United States)

    Dunbar, David C.; Godwin, John H.; Jehu, Guy R.; Perkins, Warren B.

    2018-05-01

    We extend the S-matrix of gravity by the addition of the minimal three-point amplitude or equivalently adding R3 terms to the Lagrangian. We demonstrate how Unitarity can be used to simply examine the renormalisability of this theory and determine the R4 counter-terms that arise at one-loop. We find that the combination of R4 terms that arise in the extended theory is complementary to the R4 counter-term associated with supersymmetric Lagrangians.

  4. Loop-quantum-gravity vertex amplitude.

    Science.gov (United States)

    Engle, Jonathan; Pereira, Roberto; Rovelli, Carlo

    2007-10-19

    Spin foam models are hoped to provide the dynamics of loop-quantum gravity. However, the most popular of these, the Barrett-Crane model, does not have the good boundary state space and there are indications that it fails to yield good low-energy n-point functions. We present an alternative dynamics that can be derived as a quantization of a Regge discretization of Euclidean general relativity, where second class constraints are imposed weakly. Its state space matches the SO(3) loop gravity one and it yields an SO(4)-covariant vertex amplitude for Euclidean loop gravity.

  5. Speech production in amplitude-modulated noise

    DEFF Research Database (Denmark)

    Macdonald, Ewen N; Raufer, Stefan

    2013-01-01

    The Lombard effect refers to the phenomenon where talkers automatically increase their level of speech in a noisy environment. While many studies have characterized how the Lombard effect influences different measures of speech production (e.g., F0, spectral tilt, etc.), few have investigated...... the consequences of temporally fluctuating noise. In the present study, 20 talkers produced speech in a variety of noise conditions, including both steady-state and amplitude-modulated white noise. While listening to noise over headphones, talkers produced randomly generated five word sentences. Similar...... of noisy environments and will alter their speech accordingly....

  6. Optical twists in phase and amplitude

    DEFF Research Database (Denmark)

    Daria, Vincent R.; Palima, Darwin; Glückstad, Jesper

    2011-01-01

    where both phase and amplitude express a helical profile as the beam propagates in free space. Such a beam can be accurately referred to as an optical twister. We characterize optical twisters and demonstrate their capacity to induce spiral motion on particles trapped along the twisters’ path. Unlike LG...... beams, the far field projection of the twisted optical beam maintains a high photon concentration even at higher values of topological charge. Optical twisters have therefore profound applications to fundamental studies of light and atoms such as in quantum entanglement of the OAM, toroidal traps...

  7. First order correction to quasiclassical scattering amplitude

    International Nuclear Information System (INIS)

    Kuz'menko, A.V.

    1978-01-01

    First order (with respect to h) correction to quasiclassical with the aid of scattering amplitude in nonrelativistic quantum mechanics is considered. This correction is represented by two-loop diagrams and includes the double integrals. With the aid of classical equations of motion, the sum of the contributions of the two-loop diagrams is transformed into the expression which includes one-dimensional integrals only. The specific property of the expression obtained is that the integrand does not possess any singularities in the focal points of the classical trajectory. The general formula takes much simpler form in the case of one-dimensional systems

  8. Tomography for amplitudes of hard exclusive processes

    International Nuclear Information System (INIS)

    Polyakov, M.V.

    2008-01-01

    We discuss which part of information about hadron structure encoded in the Generalized Parton Distributions (GPDs) [part of total GPD image] can be restored from the known amplitude of a hard exclusive process. The physics content of this partial image is analyzed. Among other things, we show that this partial image contains direct information about how the target hadron responses to the (string) quark-antiquark operator of arbitrary spin J. Explicit equations relating physics content of the partial image of GPDs directly to the data are derived. Also some new results concerning the dual parametrization of GPDs are presented

  9. Inverse amplitude method and Adler zeros

    International Nuclear Information System (INIS)

    Gomez Nicola, A.; Pelaez, J. R.; Rios, G.

    2008-01-01

    The inverse amplitude method is a powerful unitarization technique to enlarge the energy applicability region of effective Lagrangians. It has been widely used to describe resonances in hadronic physics, combined with chiral perturbation theory, as well as in the strongly interacting symmetry breaking sector. In this work we show how it can be slightly modified to also account for the subthreshold region, incorporating correctly the Adler zeros required by chiral symmetry and eliminating spurious poles. These improvements produce negligible effects on the physical region.

  10. Survey of vibration amplitudes throughout the linac

    International Nuclear Information System (INIS)

    Werner, K.L.

    1984-01-01

    The magnitude of vibrations of the Linac structure due to on site disturbances, such as cooling towers, pumps, generators, Highway 280 overpass traffic, is of interest. CN-263, for example, discusses tolerances of random (i.e., uncorrelated) quad jitter and suggests that amplitudes should not exceed 0.7 microns rms. This note describes the results of a series of measurements carried out in the summer of 1983. In general, the tolerance is not exceeded, but there appears not to be a good safety factor at low frequencies

  11. Generation of longitudinally polarized terahertz pulses with field amplitudes exceeding 2 kV/cm

    Energy Technology Data Exchange (ETDEWEB)

    Cliffe, M. J., E-mail: Matthew.Cliffe@manchester.ac.uk; Rodak, A.; Graham, D. M. [School of Physics and Astronomy and the Photon Science Institute, The University of Manchester, Manchester M13 9PL (United Kingdom); The Cockcroft Institute, Sci-Tech Daresbury, Keckwick Lane, Daresbury, Warrington WA4 4AD (United Kingdom); Jamison, S. P. [The Cockcroft Institute, Sci-Tech Daresbury, Keckwick Lane, Daresbury, Warrington WA4 4AD (United Kingdom); Accelerator Science and Technology Centre, Science and Technology Facilities Council, Darebsury Laboratory, Keckwick Lane, Daresbury, Warrington WA4 4AD (United Kingdom)

    2014-11-10

    We demonstrate the generation of near-single cycle longitudinally polarized terahertz radiation using a large-area radially biased photoconductive antenna with a longitudinal field amplitude in excess of 2 kV/cm. The 76 mm diameter antenna was photo-excited by a 0.5 mJ amplified near-infrared femtosecond laser system and biased with a voltage of up to 100 kV applied over concentric electrodes. Amplitudes for both the transverse and longitudinal field components of the source were measured using a calibrated electro-optic detection scheme. By tightly focusing the radiation emitted from the photoconductive antenna, we obtained a maximum longitudinal field amplitude of 2.22 kV/cm with an applied bias field of 38.5 kV/cm.

  12. Generation of longitudinally polarized terahertz pulses with field amplitudes exceeding 2 kV/cm

    Science.gov (United States)

    Cliffe, M. J.; Rodak, A.; Graham, D. M.; Jamison, S. P.

    2014-11-01

    We demonstrate the generation of near-single cycle longitudinally polarized terahertz radiation using a large-area radially biased photoconductive antenna with a longitudinal field amplitude in excess of 2 kV/cm. The 76 mm diameter antenna was photo-excited by a 0.5 mJ amplified near-infrared femtosecond laser system and biased with a voltage of up to 100 kV applied over concentric electrodes. Amplitudes for both the transverse and longitudinal field components of the source were measured using a calibrated electro-optic detection scheme. By tightly focusing the radiation emitted from the photoconductive antenna, we obtained a maximum longitudinal field amplitude of 2.22 kV/cm with an applied bias field of 38.5 kV/cm.

  13. Generation of longitudinally polarized terahertz pulses with field amplitudes exceeding 2 kV/cm

    International Nuclear Information System (INIS)

    Cliffe, M. J.; Rodak, A.; Graham, D. M.; Jamison, S. P.

    2014-01-01

    We demonstrate the generation of near-single cycle longitudinally polarized terahertz radiation using a large-area radially biased photoconductive antenna with a longitudinal field amplitude in excess of 2 kV/cm. The 76 mm diameter antenna was photo-excited by a 0.5 mJ amplified near-infrared femtosecond laser system and biased with a voltage of up to 100 kV applied over concentric electrodes. Amplitudes for both the transverse and longitudinal field components of the source were measured using a calibrated electro-optic detection scheme. By tightly focusing the radiation emitted from the photoconductive antenna, we obtained a maximum longitudinal field amplitude of 2.22 kV/cm with an applied bias field of 38.5 kV/cm

  14. System for memorizing maximum values

    Science.gov (United States)

    Bozeman, Richard J., Jr.

    1992-08-01

    The invention discloses a system capable of memorizing maximum sensed values. The system includes conditioning circuitry which receives the analog output signal from a sensor transducer. The conditioning circuitry rectifies and filters the analog signal and provides an input signal to a digital driver, which may be either linear or logarithmic. The driver converts the analog signal to discrete digital values, which in turn triggers an output signal on one of a plurality of driver output lines n. The particular output lines selected is dependent on the converted digital value. A microfuse memory device connects across the driver output lines, with n segments. Each segment is associated with one driver output line, and includes a microfuse that is blown when a signal appears on the associated driver output line.

  15. Remarks on the maximum luminosity

    Science.gov (United States)

    Cardoso, Vitor; Ikeda, Taishi; Moore, Christopher J.; Yoo, Chul-Moon

    2018-04-01

    The quest for fundamental limitations on physical processes is old and venerable. Here, we investigate the maximum possible power, or luminosity, that any event can produce. We show, via full nonlinear simulations of Einstein's equations, that there exist initial conditions which give rise to arbitrarily large luminosities. However, the requirement that there is no past horizon in the spacetime seems to limit the luminosity to below the Planck value, LP=c5/G . Numerical relativity simulations of critical collapse yield the largest luminosities observed to date, ≈ 0.2 LP . We also present an analytic solution to the Einstein equations which seems to give an unboundedly large luminosity; this will guide future numerical efforts to investigate super-Planckian luminosities.

  16. Maximum mutual information regularized classification

    KAUST Repository

    Wang, Jim Jing-Yan

    2014-09-07

    In this paper, a novel pattern classification approach is proposed by regularizing the classifier learning to maximize mutual information between the classification response and the true class label. We argue that, with the learned classifier, the uncertainty of the true class label of a data sample should be reduced by knowing its classification response as much as possible. The reduced uncertainty is measured by the mutual information between the classification response and the true class label. To this end, when learning a linear classifier, we propose to maximize the mutual information between classification responses and true class labels of training samples, besides minimizing the classification error and reducing the classifier complexity. An objective function is constructed by modeling mutual information with entropy estimation, and it is optimized by a gradient descend method in an iterative algorithm. Experiments on two real world pattern classification problems show the significant improvements achieved by maximum mutual information regularization.

  17. Scintillation counter, maximum gamma aspect

    International Nuclear Information System (INIS)

    Thumim, A.D.

    1975-01-01

    A scintillation counter, particularly for counting gamma ray photons, includes a massive lead radiation shield surrounding a sample-receiving zone. The shield is disassembleable into a plurality of segments to allow facile installation and removal of a photomultiplier tube assembly, the segments being so constructed as to prevent straight-line access of external radiation through the shield into radiation-responsive areas. Provisions are made for accurately aligning the photomultiplier tube with respect to one or more sample-transmitting bores extending through the shield to the sample receiving zone. A sample elevator, used in transporting samples into the zone, is designed to provide a maximum gamma-receiving aspect to maximize the gamma detecting efficiency. (U.S.)

  18. Maximum mutual information regularized classification

    KAUST Repository

    Wang, Jim Jing-Yan; Wang, Yi; Zhao, Shiguang; Gao, Xin

    2014-01-01

    In this paper, a novel pattern classification approach is proposed by regularizing the classifier learning to maximize mutual information between the classification response and the true class label. We argue that, with the learned classifier, the uncertainty of the true class label of a data sample should be reduced by knowing its classification response as much as possible. The reduced uncertainty is measured by the mutual information between the classification response and the true class label. To this end, when learning a linear classifier, we propose to maximize the mutual information between classification responses and true class labels of training samples, besides minimizing the classification error and reducing the classifier complexity. An objective function is constructed by modeling mutual information with entropy estimation, and it is optimized by a gradient descend method in an iterative algorithm. Experiments on two real world pattern classification problems show the significant improvements achieved by maximum mutual information regularization.

  19. K time & maximum amplitude of thromboelastogram predict post-central venous cannulation bleeding in patients with cirrhosis: A pilot study

    Directory of Open Access Journals (Sweden)

    Chandra K Pandey

    2017-01-01

    Interpretation & conclusions: Our results show that the cut-off value for INR ≥2.6 and K time ≥3.05 min predict bleeding and MA ≥48.8 mm predicts non-bleeding in patients with cirrhosis undergoing central venous pressure catheter cannulation.

  20. Multichannel amplitude analyser for nuclear spectrometry

    International Nuclear Information System (INIS)

    Jankovic, S.; Milovanovic, B.

    2003-01-01

    A multichannel amplitude analyser with 4096 channels was designed. It is based on a fast 12-bit analog-to-digital converter. The intended purpose of the instrument is recording nuclear spectra by means of scintillation detectors. The computer link is established through an opto-isolated serial connection cable, thus reducing instrument sensitivity to disturbances originating from digital circuitry. Refreshing of the data displayed on the screen occurs on every 2.5 seconds. The impulse peak detection is implemented through the differentiation of the amplified input signal, while the synchronization with the data coming from the converter output is established by taking advantage of the internal 'pipeline' structure of the converter itself. The mode of operation of the built-in microcontroller provides that there are no missed impulses, and the simple logic network prevents the initiation of the amplitude reading sequence for the next impulse in case it appears shortly after its precedent. The solution proposed here demonstrated a good performance at a comparatively low manufacturing cost, and is thus suitable for educational purposes (author)

  1. Getting superstring amplitudes by degenerating Riemann surfaces

    International Nuclear Information System (INIS)

    Matone, Marco; Volpato, Roberto

    2010-01-01

    We explicitly show how the chiral superstring amplitudes can be obtained through factorisation of the higher genus chiral measure induced by suitable degenerations of Riemann surfaces. This powerful tool also allows to derive, at any genera, consistency relations involving the amplitudes and the measure. A key point concerns the choice of the local coordinate at the node on degenerate Riemann surfaces that greatly simplifies the computations. As a first application, starting from recent ansaetze for the chiral measure up to genus five, we compute the chiral two-point function for massless Neveu-Schwarz states at genus two, three and four. For genus higher than three, these computations include some new corrections to the conjectural formulae appeared so far in the literature. After GSO projection, the two-point function vanishes at genus two and three, as expected from space-time supersymmetry arguments, but not at genus four. This suggests that the ansatz for the superstring measure should be corrected for genus higher than four.

  2. The Construction of Spin Foam Vertex Amplitudes

    Directory of Open Access Journals (Sweden)

    Eugenio Bianchi

    2013-01-01

    Full Text Available Spin foam vertex amplitudes are the key ingredient of spin foam models for quantum gravity. These fall into the realm of discretized path integral, and can be seen as generalized lattice gauge theories. They can be seen as an attempt at a 4-dimensional generalization of the Ponzano-Regge model for 3d quantum gravity. We motivate and review the construction of the vertex amplitudes of recent spin foam models, giving two different and complementary perspectives of this construction. The first proceeds by extracting geometric configurations from a topological theory of the BF type, and can be seen to be in the tradition of the work of Barrett, Crane, Freidel and Krasnov. The second keeps closer contact to the structure of Loop Quantum Gravity and tries to identify an appropriate set of constraints to define a Lorentz-invariant interaction of its quanta of space. This approach is in the tradition of the work of Smolin, Markopoulous, Engle, Pereira, Rovelli and Livine.

  3. Fatigue life prediction of rotor blade composites: Validation of constant amplitude formulations with variable amplitude experiments

    International Nuclear Information System (INIS)

    Westphal, T; Nijssen, R P L

    2014-01-01

    The effect of Constant Life Diagram (CLD) formulation on the fatigue life prediction under variable amplitude (VA) loading was investigated based on variable amplitude tests using three different load spectra representative for wind turbine loading. Next to the Wisper and WisperX spectra, the recently developed NewWisper2 spectrum was used. Based on these variable amplitude fatigue results the prediction accuracy of 4 CLD formulations is investigated. In the study a piecewise linear CLD based on the S-N curves for 9 load ratios compares favourably in terms of prediction accuracy and conservativeness. For the specific laminate used in this study Boerstra's Multislope model provides a good alternative at reduced test effort

  4. Fatigue life prediction of rotor blade composites: Validation of constant amplitude formulations with variable amplitude experiments

    Science.gov (United States)

    Westphal, T.; Nijssen, R. P. L.

    2014-12-01

    The effect of Constant Life Diagram (CLD) formulation on the fatigue life prediction under variable amplitude (VA) loading was investigated based on variable amplitude tests using three different load spectra representative for wind turbine loading. Next to the Wisper and WisperX spectra, the recently developed NewWisper2 spectrum was used. Based on these variable amplitude fatigue results the prediction accuracy of 4 CLD formulations is investigated. In the study a piecewise linear CLD based on the S-N curves for 9 load ratios compares favourably in terms of prediction accuracy and conservativeness. For the specific laminate used in this study Boerstra's Multislope model provides a good alternative at reduced test effort.

  5. Resting-state functional MR changes in Alzheimer's disease patients visualized by amplitude of low-frequency fluctuation and fraction of amplitude of low-frequency fluctuation

    International Nuclear Information System (INIS)

    Long Miaomiao; Ni Hongyan; Feng Jie; Zhang Hongtao; Liu Tie; Shen Wen; Qi Ji

    2013-01-01

    Objective: To investigate the difference of amplitude of low-frequency fluctuation (ALFF) and fraction of amplitude of low-frequency fluctuation (fALFF) between Alzheimer's disease (AD)patients and normal aging (NA) controls by voxel-based analysis. Methods: Thirty-one AD patients and 44 NA controls were enrolled in the study. Blood oxygen level dependent functional (BOLD) EPI data were obtained during resting-state by using 32-channel head coil. Data were realigned, normalized and then smoothed with 8 mm FWHM kernel. Resting-state fMRI toolkit (version 1.6) was used to generate ALFF and fALFF images. Independent two sample t-test was performed with SPM5 to compare ALFF and fALFF of AD and NA controls. Pearson correlation analysis was performed to examine the relationship between MMSE score and ALFF, fALFF parameters. The significance level was set to be uncorrected O.001 on the voxel level and 0.05 on the cluster level. Results: AD patients showed increased ALFF in left temporal lobe (0.492 ± 0.119) and right cingulated cortex (0.434 ± 0.093) of AD patients, which were 0.443 ± 0.068 and 0.380 ± 0.081 in NA controls (t = 2.658, 2.227, P < 0.05). Decreased fALFF was found in bilateral posterior cingulate cortices (1.167 ± 0.203) and increased fALFF was found in bilateral temporal lobes (left 1.226 ± 0.127, right 1.146 ± 0.214) with left side dominance, which were 1.453 ± 0.269, 1.134 ± 0.088, 1.014 ± O.132 in NA controls (t =5.001, 3.695, 3.285, P < 0.05). Bilateral temporal ALFF and fALFF correlated with MMSE positively (r = 0.768-0.909, P < 0.05) with left dominance. Conclusion: AD patients showed increased resting-state functional MRI changes correlated with MMSE score in the temporal lobes with left dominance, which indicated left temporal lobe may be the best location for the observation of disease progression in AD patients. (authors)

  6. Tsunami Amplitude Estimation from Real-Time GNSS.

    Science.gov (United States)

    Jeffries, C.; MacInnes, B. T.; Melbourne, T. I.

    2017-12-01

    Tsunami early warning systems currently comprise modeling of observations from the global seismic network, deep-ocean DART buoys, and a global distribution of tide gauges. While these tools work well for tsunamis traveling teleseismic distances, saturation of seismic magnitude estimation in the near field can result in significant underestimation of tsunami excitation for local warning. Moreover, DART buoy and tide gauge observations cannot be used to rectify the underestimation in the available time, typically 10-20 minutes, before local runup occurs. Real-time GNSS measurements of coseismic offsets may be used to estimate finite faulting within 1-2 minutes and, in turn, tsunami excitation for local warning purposes. We describe here a tsunami amplitude estimation algorithm; implemented for the Cascadia subduction zone, that uses continuous GNSS position streams to estimate finite faulting. The system is based on a time-domain convolution of fault slip that uses a pre-computed catalog of hydrodynamic Green's functions generated with the GeoClaw shallow-water wave simulation software and maps seismic slip along each section of the fault to points located off the Cascadia coast in 20m of water depth and relies on the principle of the linearity in tsunami wave propagation. The system draws continuous slip estimates from a message broker, convolves the slip with appropriate Green's functions which are then superimposed to produce wave amplitude at each coastal location. The maximum amplitude and its arrival time are then passed into a database for subsequent monitoring and display. We plan on testing this system using a suite of synthetic earthquakes calculated for Cascadia whose ground motions are simulated at 500 existing Cascadia GPS sites, as well as real earthquakes for which we have continuous GNSS time series and surveyed runup heights, including Maule, Chile 2010 and Tohoku, Japan 2011. This system has been implemented in the CWU Geodesy Lab for the Cascadia

  7. Towards a mechanistic understanding of vulnerability to hook-and-line fishing: Boldness as the basic target of angling-induced selection

    DEFF Research Database (Denmark)

    Klefoth, Thomas; Skov, Christian; Kuparinen, Anna

    2017-01-01

    by juvenile growth rate, while morphological traits were only weakly related to angling vulnerability. In addition, we found juvenile growth rate to be moderately correlated with boldness. Hence, direct selection on boldness will also induce indirect selection on juvenile growth and vice versa, but given......In passively operated fishing gear, boldness-related behaviors should fundamentally affect the vulnerability of individual fish and thus be under fisheries selection. To test this hypothesis, we used juvenile common-garden reared carp (Cyprinus carpio) within a narrow size range to investigate...... the mechanistic basis of behavioral selection caused by angling. We focused on one key personality trait (i.e., boldness), measured in groups within ponds, two morphological traits (body shape and head shape), and one life-history trait (juvenile growth capacity) and studied mean standardized selection gradients...

  8. Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for long-allele carriers during perceptual processing of emotional tasks

    Science.gov (United States)

    Hadi, Shamil M.; Siadat, Mohamad R.; Babajani-Feremi, Abbas

    2012-03-01

    We investigated the effect of synaptic serotonin concentration on hemodynamic responses. The stimuli paradigm involved the presentation of fearful and threatening facial expressions to a set of 24 subjects who were either5HTTLPR long- or short-allele carriers (12 of each type in each group). The BOLD signals of the rACC from subjects of each group were averaged to increase the signal-to-noise ratio. We used a Bayesian approach to estimate the parameters of the underlying hemodynamic model. Our results, during this perceptual processing of emotional task, showed a negative BOLD signal in the rACC in the subjects with long-alleles. In contrast, the subjects with short-alleles showed positive BOLD signals in the rACC. These results suggest that high synaptic serotonin concentration in the rACC inhibits neuronal activity in a fashion similar to GABA, and a consequent negative BOLD signal ensues.

  9. Ratios of helicity amplitudes for exclusive ρ0 electroproduction on transversely polarized proton

    Directory of Open Access Journals (Sweden)

    Manaenkov Serguei

    2017-01-01

    Full Text Available Exclusive ρ0-meson electroproduction is studied by the HERMES experiment, using the 27.6 GeV longitudinally polarized electron/positron beam of HERA and a transversely polarized hydrogen target, in the kinematic region 1.0 GeV2 < Q2 < 7.0 GeV2, 3.0 GeV < W < 6.3 GeV, and −t′ < 0.4 GeV2. Using an unbinned maximum-likelihood method, 25 parameters are extracted. They determine the real and imaginary parts of the ratios of certain helicity amplitudes describing ρ0-meson production by a virtual photon, where the denominator is the dominant amplitude F012012${F_{0{1 \\over 2}}}_{0{1 \\over 2}}$. The latter is the nucleon-helicity-non-flip amplitude, which describes the production of a longitudinal ρ0 meson by a longitudinal virtual photon. The transverse target polarization allows for the first time the extraction of ratios of a number of nucleon-helicity-flip amplitudes to F012012${F_{0{1 \\over 2}}}_{0{1 \\over 2}}$. The ratios of nucleon-helicity-non-flip amplitudes are found to be in good agreement with those from the previous HERMES analysis.

  10. Nonlinear rocket motor stability prediction: Limit amplitude, triggering, and mean pressure shifta)

    Science.gov (United States)

    Flandro, Gary A.; Fischbach, Sean R.; Majdalani, Joseph

    2007-09-01

    High-amplitude pressure oscillations in solid propellant rocket motor combustion chambers display nonlinear effects including: (1) limit cycle behavior in which the fluctuations may dwell for a considerable period of time near their peak amplitude, (2) elevated mean chamber pressure (DC shift), and (3) a triggering amplitude above which pulsing will cause an apparently stable system to transition to violent oscillations. Along with the obvious undesirable vibrations, these features constitute the most damaging impact of combustion instability on system reliability and structural integrity. The physical mechanisms behind these phenomena and their relationship to motor geometry and physical parameters must, therefore, be fully understood if instability is to be avoided in the design process, or if effective corrective measures must be devised during system development. Predictive algorithms now in use have limited ability to characterize the actual time evolution of the oscillations, and they do not supply the motor designer with information regarding peak amplitudes or the associated critical triggering amplitudes. A pivotal missing element is the ability to predict the mean pressure shift; clearly, the designer requires information regarding the maximum chamber pressure that might be experienced during motor operation. In this paper, a comprehensive nonlinear combustion instability model is described that supplies vital information. The central role played by steep-fronted waves is emphasized. The resulting algorithm provides both detailed physical models of nonlinear instability phenomena and the critically needed predictive capability. In particular, the origin of the DC shift is revealed.

  11. Thrombelastography Early Amplitudes in bleeding and coagulopathic trauma patients

    DEFF Research Database (Denmark)

    Laursen, Thomas Holst; Meyer, Martin A S; Meyer, Anna Sina P

    2018-01-01

    BACKGROUND: Early amplitudes in the viscoelastic hemostatic assays Thrombelastography (TEG) and Rotation Thromboelastometry (ROTEM) provide fast results, which is critical in resuscitation of bleeding patients. This study investigated associations between TEG early amplitudes and standard TEG var...

  12. BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone

    Directory of Open Access Journals (Sweden)

    Kelsey Moore

    2016-11-01

    Full Text Available Blood oxygen level dependent (BOLD imaging in awake mice was used to identify differences in brain activity between wild-type, and Mu (µ opioid receptor knock-outs (MuKO in response to oxycodone (OXY. Using a segmented, annotated MRI mouse atlas and computational analysis, patterns of integrated positive and negative BOLD activity were identified across 122 brain areas. The pattern of positive BOLD showed enhanced activation across the brain in WT mice within 15 min of intraperitoneal administration of 2.5 mg of OXY. BOLD activation was detected in 72 regions out of 122, and was most prominent in areas of high µ opioid receptor density (thalamus, ventral tegmental area, substantia nigra, caudate putamen, basal amygdala and hypothalamus, and focus on pain circuits indicated strong activation in major pain processing centers (central amygdala, solitary tract, parabrachial area, insular cortex, gigantocellularis area, ventral thalamus primary sensory cortex and prelimbic cortex. Importantly, the OXY-induced positive BOLD was eliminated in MuKO mice in most regions, with few exceptions (some cerebellar nuclei, CA3 of the hippocampus, medial amygdala and preoptic areas. This result indicates that most effects of OXY on positive BOLD are mediated by the µ opioid receptor (on-target effects. OXY also caused an increase in negative BOLD in WT mice in few regions (16 out of 122 and, unlike the positive BOLD response the negative BOLD was only partially eliminated in the MuKO mice (cerebellum, and in some case intensified (hippocampus. Negative BOLD analysis therefore shows activation and deactivation events in the absence of the µ receptor for some areas where receptor expression is normally extremely low or absent (off-target effects. Together, our approach permits establishing opioid-induced BOLD activation maps in awake mice. In addition, comparison of WT and MuKO mutant mice reveals both on-target and off-target activation events, and set an OXY

  13. Maximum entropy and Bayesian methods

    International Nuclear Information System (INIS)

    Smith, C.R.; Erickson, G.J.; Neudorfer, P.O.

    1992-01-01

    Bayesian probability theory and Maximum Entropy methods are at the core of a new view of scientific inference. These 'new' ideas, along with the revolution in computational methods afforded by modern computers allow astronomers, electrical engineers, image processors of any type, NMR chemists and physicists, and anyone at all who has to deal with incomplete and noisy data, to take advantage of methods that, in the past, have been applied only in some areas of theoretical physics. The title workshops have been the focus of a group of researchers from many different fields, and this diversity is evident in this book. There are tutorial and theoretical papers, and applications in a very wide variety of fields. Almost any instance of dealing with incomplete and noisy data can be usefully treated by these methods, and many areas of theoretical research are being enhanced by the thoughtful application of Bayes' theorem. Contributions contained in this volume present a state-of-the-art overview that will be influential and useful for many years to come

  14. Personality in the cockroach Diploptera punctata: Evidence for stability across developmental stages despite age effects on boldness

    Science.gov (United States)

    Mettke-Hofmann, Claudia; Preziosi, Richard F.

    2017-01-01

    Despite a recent surge in the popularity of animal personality studies and their wide-ranging associations with various aspects of behavioural ecology, our understanding of the development of personality over ontogeny remains poorly understood. Stability over time is a central tenet of personality; ecological pressures experienced by an individual at different life stages may, however, vary considerably, which may have a significant effect on behavioural traits. Invertebrates often go through numerous discrete developmental stages and therefore provide a useful model for such research. Here we test for both differential consistency and age effects upon behavioural traits in the gregarious cockroach Diploptera punctata by testing the same behavioural traits in both juveniles and adults. In our sample, we find consistency in boldness, exploration and sociality within adults whilst only boldness was consistent in juveniles. Both boldness and exploration measures, representative of risk-taking behaviour, show significant consistency across discrete juvenile and adult stages. Age effects are, however, apparent in our data; juveniles are significantly bolder than adults, most likely due to differences in the ecological requirements of these life stages. Size also affects risk-taking behaviour since smaller adults are both bolder and more highly explorative. Whilst a behavioural syndrome linking boldness and exploration is evident in nymphs, this disappears by the adult stage, where links between other behavioural traits become apparent. Our results therefore indicate that differential consistency in personality can be maintained across life stages despite age effects on its magnitude, with links between some personality traits changing over ontogeny, demonstrating plasticity in behavioural syndromes. PMID:28489864

  15. Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration.

    Science.gov (United States)

    Merola, Alberto; Murphy, Kevin; Stone, Alan J; Germuska, Michael A; Griffeth, Valerie E M; Blockley, Nicholas P; Buxton, Richard B; Wise, Richard G

    2016-04-01

    Several techniques have been proposed to estimate relative changes in cerebral metabolic rate of oxygen consumption (CMRO2) by exploiting combined BOLD fMRI and cerebral blood flow data in conjunction with hypercapnic or hyperoxic respiratory challenges. More recently, methods based on respiratory challenges that include both hypercapnia and hyperoxia have been developed to assess absolute CMRO2, an important parameter for understanding brain energetics. In this paper, we empirically optimize a previously presented "original calibration model" relating BOLD and blood flow signals specifically for the estimation of oxygen extraction fraction (OEF) and absolute CMRO2. To do so, we have created a set of synthetic BOLD signals using a detailed BOLD signal model to reproduce experiments incorporating hypercapnic and hyperoxic respiratory challenges at 3T. A wide range of physiological conditions was simulated by varying input parameter values (baseline cerebral blood volume (CBV0), baseline cerebral blood flow (CBF0), baseline oxygen extraction fraction (OEF0) and hematocrit (Hct)). From the optimization of the calibration model for estimation of OEF and practical considerations of hypercapnic and hyperoxic respiratory challenges, a new "simplified calibration model" is established which reduces the complexity of the original calibration model by substituting the standard parameters α and β with a single parameter θ. The optimal value of θ is determined (θ=0.06) across a range of experimental respiratory challenges. The simplified calibration model gives estimates of OEF0 and absolute CMRO2 closer to the true values used to simulate the experimental data compared to those estimated using the original model incorporating literature values of α and β. Finally, an error propagation analysis demonstrates the susceptibility of the original and simplified calibration models to measurement errors and potential violations in the underlying assumptions of isometabolism

  16. The effect of renal denervation on kidney oxygenation as determined by BOLD MRI in patients with hypertension

    Energy Technology Data Exchange (ETDEWEB)

    Vink, E.E.; Boer, A.; Blankestijn, P.J. [University Medical Center Utrecht, Department of Nephrology, P.O. Box 85500, GA, Utrecht (Netherlands); Verloop, W.L.; Voskuil, M. [University Medical Center Utrecht, Department of Cardiology, Utrecht (Netherlands); Spiering, W.; Leiner, T. [University Medical Center Utrecht, Department of Vascular Medicine, Utrecht (Netherlands); Vonken, E.; Hoogduin, J.M. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Bots, M.L. [University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht (Netherlands)

    2015-07-15

    Renal denervation (RDN) is a promising therapy for resistant hypertension. RDN is assumed to decrease sympathetic activity. Consequently, RDN can potentially increase renal oxygenation. Blood oxygen level-dependent MRI (BOLD-MRI) provides a non-invasive tool to determine renal oxygenation in humans. The aim of the current study was to investigate the effect of RDN on renal oxygenation as determined by BOLD-MRI. Patients with resistant hypertension or the inability to follow a stable drug regimen due to unacceptable side effects were included. BOLD-MRI was performed before and 12 months after RDN. Twenty-seven patients were imaged on 3 T and 19 on 1.5 T clinical MRI systems. Fifty-four patients were included, 46 patients (23 men, mean age 57 years) completed the study. Mean 24-h BP changed from 163(±20)/98(±14) mmHg to 154(±22)/92(±13) mmHg (p = 0.001 and p < 0.001). eGFR did not change after RDN [77(±18) vs. 79(±20) mL/min/1.73 m{sup 2}; p = 0.13]. RDN did not affect renal oxygenation [1.5 T: cortical R2*: 12.5(±0.9) vs. 12.5(±0.9), p = 0.94; medullary R2*: 19.6(±1.7) vs. 19.3(1.4), p = 0.40; 3 T: cortical R2*: 18.1(±0.8) vs. 17.8(±1.2), p = 0.47; medullary R2*: 27.4(±1.9) vs. 26.7(±1.8), p = 0.19]. The current study shows that RDN does not lead to changes in renal oxygenation 1 year after RDN as determined by BOLD-MRI. (orig.)

  17. Personality in the cockroach Diploptera punctata: Evidence for stability across developmental stages despite age effects on boldness.

    Science.gov (United States)

    Stanley, Christina R; Mettke-Hofmann, Claudia; Preziosi, Richard F

    2017-01-01

    Despite a recent surge in the popularity of animal personality studies and their wide-ranging associations with various aspects of behavioural ecology, our understanding of the development of personality over ontogeny remains poorly understood. Stability over time is a central tenet of personality; ecological pressures experienced by an individual at different life stages may, however, vary considerably, which may have a significant effect on behavioural traits. Invertebrates often go through numerous discrete developmental stages and therefore provide a useful model for such research. Here we test for both differential consistency and age effects upon behavioural traits in the gregarious cockroach Diploptera punctata by testing the same behavioural traits in both juveniles and adults. In our sample, we find consistency in boldness, exploration and sociality within adults whilst only boldness was consistent in juveniles. Both boldness and exploration measures, representative of risk-taking behaviour, show significant consistency across discrete juvenile and adult stages. Age effects are, however, apparent in our data; juveniles are significantly bolder than adults, most likely due to differences in the ecological requirements of these life stages. Size also affects risk-taking behaviour since smaller adults are both bolder and more highly explorative. Whilst a behavioural syndrome linking boldness and exploration is evident in nymphs, this disappears by the adult stage, where links between other behavioural traits become apparent. Our results therefore indicate that differential consistency in personality can be maintained across life stages despite age effects on its magnitude, with links between some personality traits changing over ontogeny, demonstrating plasticity in behavioural syndromes.

  18. Approaches to brain stress testing: BOLD magnetic resonance imaging with computer-controlled delivery of carbon dioxide.

    Directory of Open Access Journals (Sweden)

    W Alan C Mutch

    Full Text Available BACKGROUND: An impaired vascular response in the brain regionally may indicate reduced vascular reserve and vulnerability to ischemic injury. Changing the carbon dioxide (CO(2 tension in arterial blood is commonly used as a cerebral vasoactive stimulus to assess the cerebral vascular response, changing cerebral blood flow (CBF by up to 5-11 percent/mmHg in normal adults. Here we describe two approaches to generating the CO(2 challenge using a computer-controlled gas blender to administer: i a square wave change in CO(2 and, ii a ramp stimulus, consisting of a continuously graded change in CO(2 over a range. Responses were assessed regionally by blood oxygen level dependent (BOLD magnetic resonance imaging (MRI. METHODOLOGY/PRINCIPAL FINDINGS: We studied 8 patients with known cerebrovascular disease (carotid stenosis or occlusion and 2 healthy subjects. The square wave stimulus was used to study the dynamics of the vascular response, while the ramp stimulus assessed the steady-state response to CO(2. Cerebrovascular reactivity (CVR maps were registered by color coding and overlaid on the anatomical scans generated with 3 Tesla MRI to assess the corresponding BOLD signal change/mmHg change in CO(2, voxel-by-voxel. Using a fractal temporal approach, detrended fluctuation analysis (DFA maps of the processed raw BOLD signal per voxel over the same CO(2 range were generated. Regions of BOLD signal decrease with increased CO(2 (coded blue were seen in all of these high-risk patients, indicating regions of impaired CVR. All patients also demonstrated regions of altered signal structure on DFA maps (Hurst exponents less than 0.5; coded blue indicative of anti-persistent noise. While 'blue' CVR maps remained essentially stable over the time of analysis, 'blue' DFA maps improved. CONCLUSIONS/SIGNIFICANCE: This combined dual stimulus and dual analysis approach may be complementary in identifying vulnerable brain regions and thus constitute a regional as

  19. Resting State BOLD Variability in Alzheimer’s Disease: A Marker of Cognitive Decline or Cerebrovascular Status?

    Directory of Open Access Journals (Sweden)

    Vanessa Scarapicchia

    2018-02-01

    Full Text Available Background: Alzheimer’s disease (AD is a neurodegenerative disorder that may benefit from early diagnosis and intervention. Therefore, there is a need to identify early biomarkers of AD using non-invasive techniques such as functional magnetic resonance imaging (fMRI. Recently, novel approaches to the analysis of resting-state fMRI data have been developed that focus on the moment-to-moment variability in the blood oxygen level dependent (BOLD signal. The objective of the current study was to investigate BOLD variability as a novel early biomarker of AD and its associated psychophysiological correlates.Method: Data were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI 2 database from 19 participants with AD and 19 similarly aged controls. For each participant, a map of BOLD signal variability (SDBOLD was computed as the standard deviation of the BOLD timeseries at each voxel. Group comparisons were performed to examine global differences in resting state SDBOLD in AD versus healthy controls. Correlations were then examined between participant SDBOLD maps and (1 ADNI-derived composite scores of memory and executive function and (2 neuroimaging markers of cerebrovascular status.Results: Between-group comparisons revealed significant (p < 0.05 increases in SDBOLD in patients with AD relative to healthy controls in right-lateralized frontal regions. Lower memory scores and higher WMH burden were associated with greater SDBOLD in the healthy control group (p < 0.1, but not individuals with AD.Conclusion: The current study provides proof of concept of a novel resting state fMRI analysis technique that is non-invasive, easily accessible, and clinically compatible. To further explore the potential of SDBOLD as a biomarker of AD, additional studies in larger, longitudinal samples are needed to better understand the changes in SDBOLD that characterize earlier stages of disease progression and their underlying psychophysiological

  20. Variational principles for the projected breakup amplitude

    International Nuclear Information System (INIS)

    Hahn, Y.

    1976-01-01

    Two alternate forms of variational principles for the breakup amplitude describing the two- to three-cluster transition are derived such that all the integrals involved in the intermediate stages are well defined. The first form contains a trial Green's function with which both the initial and final state trial wave functions are constructed. The earlier form of the Kohn-type variational principle derived by Lieber, Rosenberg, and Spruch is recovered, however, when this connection between the trial functions is removed. The second form of the variational principle is derived by projecting out from the trial functions all the open channel components which correspond to the two-cluster structures including the rearrangement channels. The remaining part of the wave functions describes the channels with three-cluster structures, and the integrals involving this part are then mathematically well defined

  1. Single isospin decay amplitude and CP violation

    Energy Technology Data Exchange (ETDEWEB)

    Deshpande, N.G. [Oregon Univ., Eugene, OR (United States). Inst. of Theoretical Science; He, Xiaogang [Melbourne Univ., Parkville, VIC (Australia). School of Physics; Pakvasa, S. [Hawaii Univ., Honolulu, HI (United States). Dept. of Physics and Astronomy

    1996-06-01

    While for K meson or hyperon decays, the partial rate asymmetries are always zero if the final states are single isospin states, in B decays the situation is dramatically different and partial rate asymmetries can be non-zero if the final states are single isospin states. Partial rate asymmetries were calculated for several B decays with single isospin amplitude in the finale states using factorization approximation. It was found that more intermediate on-shell states with different Cabbibbo-Kobayashi-Maskawa factors are allowed in B decay and CP violating partial rate asymmetries need not to be zero even if the final state contains only a single isospin state. 17 refs., 4 figs.

  2. Large amplitude parallel propagating electromagnetic oscillitons

    International Nuclear Information System (INIS)

    Cattaert, Tom; Verheest, Frank

    2005-01-01

    Earlier systematic nonlinear treatments of parallel propagating electromagnetic waves have been given within a fluid dynamic approach, in a frame where the nonlinear structures are stationary and various constraining first integrals can be obtained. This has lead to the concept of oscillitons that has found application in various space plasmas. The present paper differs in three main aspects from the previous studies: first, the invariants are derived in the plasma frame, as customary in the Sagdeev method, thus retaining in Maxwell's equations all possible effects. Second, a single differential equation is obtained for the parallel fluid velocity, in a form reminiscent of the Sagdeev integrals, hence allowing a fully nonlinear discussion of the oscilliton properties, at such amplitudes as the underlying Mach number restrictions allow. Third, the transition to weakly nonlinear whistler oscillitons is done in an analytical rather than a numerical fashion

  3. Amplitude and phase modulation with waveguide optics

    International Nuclear Information System (INIS)

    Burkhart, S.C.; Wilcox, R.B.; Browning, D.; Penko, F.A.

    1996-01-01

    We have developed amplitude and phase modulation systems for glass lasers using integrated electro-optic modulators and solid state high-speed electronics. The present and future generation of lasers for Inertial Confinement Fusion require laser beams with complex temporal and phase shaping to compensate for laser gain saturation, mitigate parametric processes such as transverse stimulated Brillouin scattering in optics, and to provide specialized drive to the fusion targets. These functions can be performed using bulk optoelectronic modulators, however using high-speed electronics to drive low voltage integrated optical modulators has many practical advantages. In particular, we utilize microwave GaAs transistors to perform precision, 250 ps resolution temporal shaping. Optical bandwidth is generated using a microwave oscillator at 3 GHz amplified by a solid state amplifier. This drives an integrated electrooptic modulator to achieve laser bandwidths exceeding 30 GHz

  4. Topological amplitudes in heterotic superstring theory

    International Nuclear Information System (INIS)

    Antoniadis, I.; Taylor, T.R.

    1996-06-01

    We show that certain heterotic string amplitudes are given in terms of correlators of the twisted topological (2,0) SCFT, corresponding to the internal sector of the N = 1 spacetime supersymmetric background. The genus g topological partition function F g corresponds to a term in the effective action of the form W 2g , where W is the gauge or gravitational superfield. We study also recursion relations related to holomorphic anomalies, showing that, contrary to the type II case, they involve correlators of anti-chiral superfields. The corresponding terms in the effective action are of the form W 2g II n , where II is a chiral superfield obtained by chiral projection of a general superfield. We observe that the structure of the recursion relations is that of N = 1 spacetime supersymmetry Ward identity. We give also a solution of the tree level recursion relations and discuss orbifold examples. (author). 23 refs, 2 figs

  5. Polynomial structures in one-loop amplitudes

    International Nuclear Information System (INIS)

    Britto, Ruth; Feng Bo; Yang Gang

    2008-01-01

    A general one-loop scattering amplitude may be expanded in terms of master integrals. The coefficients of the master integrals can be obtained from tree-level input in a two-step process. First, use known formulas to write the coefficients of (4-2ε)-dimensional master integrals; these formulas depend on an additional variable, u, which encodes the dimensional shift. Second, convert the u-dependent coefficients of (4-2ε)-dimensional master integrals to explicit coefficients of dimensionally shifted master integrals. This procedure requires the initial formulas for coefficients to have polynomial dependence on u. Here, we give a proof of this property in the case of massless propagators. The proof is constructive. Thus, as a byproduct, we produce different algebraic expressions for the scalar integral coefficients, in which the polynomial property is apparent. In these formulas, the box and pentagon contributions are separated explicitly.

  6. Systematic protocol for assessment of the validity of BOLD MRI in a rabbit model of inflammatory arthritis at 1.5 tesla

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Michael W.; Nathanael, George; Kis, Antonella; Amirabadi, Afsaneh; Zhong, Anguo; Rayner, Tammy; Weiss, Ruth; Detzler, Garry; Gahunia, Harpal [The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto (Canada); Jong, Roland [Mount Sinai Hospital, Department of Pathology and Laboratory Medicine, Toronto (Canada); Moineddin, Rahim [Family and Community Medicine, Department of Public Health, Toronto (Canada); Crawley, Adrian [University of Toronto, Department of Medical Imaging, Toronto (Canada); Toronto Western Hospital, Department of Medical Imaging, Toronto (Canada); Doria, Andrea S. [The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto (Canada); University of Toronto, Department of Medical Imaging, Toronto (Canada)

    2014-05-15

    Blood-oxygen-level-dependent (BOLD) MRI has the potential to identify regions of early hypoxic and vascular joint changes in inflammatory arthritis. There is no standard protocol for analysis of BOLD MRI measurements in musculoskeletal disorders. To optimize the following BOLD MRI reading parameters: (1) statistical threshold values (low, r > 0.01 versus high, r > 0.2); (2) summary measures of BOLD contrast (percentage of activated voxels [PT%] versus percentage signal difference between on-and-off signal intensities [diff{sub o}n{sub o}ff]); and (3) direction of BOLD response (positive, negative and positive + negative). Using BOLD MRI protocols at 1.5 T, arthritic (n = 21) and contralateral (n = 21) knees of 21 juvenile rabbits were imaged at baseline and on days 1, 14 and 28 after a unilateral intra-articular injection of carrageenan. Nine non-injected rabbits served as external control knees (n = 18). By comparing arthritic to contralateral knees, receiver operating characteristic curves were used to determine diagnostic accuracy. Using diff{sub o}n{sub o}ff and positive + negative responses, a threshold of r > 0.01 was more accurate than r > 0.2 (P = 0.03 at day 28). Comparison of summary measures yielded no statistically significant difference (P > 0.05). Although positive + negative (AUC = 0.86 at day 28) and negative responses (AUC = 0.90 at day 28) for PT% were the most diagnostically accurate, positive + negative responses for diff{sub o}n{sub o}ff (AUC = 0.78 at day 28) also had acceptable accuracy. The most clinically relevant reading parameters included a lower threshold of r > 0.01 and a positive + negative BOLD response. We propose that diff{sub o}n{sub o}ff is a more clinically relevant summary measure of BOLD MRI, while PT% can be used as an ancillary measure. (orig.)

  7. Amplitude correlations for inelastic proton scattering from 48Ti

    International Nuclear Information System (INIS)

    Chou, B.H.; Mitchell, G.E.; Bilpuch, E.G.; Westerfeldt, C.R.

    1981-01-01

    The magnitudes and relative signs of inelastic proton channel amplitudes were determined for three decay channels for 45 5/2 + resonances in 49 V. The reduced widths in each channel follow a Porter-Thomas distribution, but extremely large amplitude correlations are observed - for one pair of channel amplitudes the relative sign is positive for 43 of 45 resonances. These results provide the first direct test of the Krieger-Porter reduced width amplitude distribution. (orig.)

  8. Tree-level gluon amplitudes on the celestial sphere

    Science.gov (United States)

    Schreiber, Anders Ø.; Volovich, Anastasia; Zlotnikov, Michael

    2018-06-01

    Pasterski, Shao and Strominger have recently proposed that massless scattering amplitudes can be mapped to correlators on the celestial sphere at infinity via a Mellin transform. We apply this prescription to arbitrary n-point tree-level gluon amplitudes. The Mellin transforms of MHV amplitudes are given by generalized hypergeometric functions on the Grassmannian Gr (4 , n), while generic non-MHV amplitudes are given by more complicated Gelfand A-hypergeometric functions.

  9. Correlations for reduced-width amplitudes in 49V

    International Nuclear Information System (INIS)

    Chou, B.H.; Mitchell, G.E.; Bilpuch, E.G.; Westerfeldt, C.R.

    1980-01-01

    Measurement of the relative sign of inelastic proton-channel amplitudes permits the determination of amplitude correlations. Data were obtained for 45 5/2 + resonances in 49 V. Although the reduced widths in each channel followed a Porter-Thomas distribution, large amplitude correlations were observed. The results are compared with the reduced-width--amplitude distribution of Krieger and Porter. This is the first direct test of the Krieger-Porter distribution

  10. The association between chronic airflow obstruction and poverty in 12 sites of the multinational BOLD study.

    Science.gov (United States)

    Townend, John; Minelli, Cosetta; Mortimer, Kevin; Obaseki, Daniel O; Al Ghobain, Mohammed; Cherkaski, Hamid; Denguezli, Myriam; Gunesekera, Kirthi; Hafizi, Hasan; Koul, Parvaiz A; Loh, Li C; Nejjari, Chakib; Patel, Jaymini; Sooronbayev, Talant; Buist, Sonia A; Burney, Peter G J

    2017-06-01

    Poverty is strongly associated with mortality from COPD, but little is known of its relation to airflow obstruction.In a cross-sectional study of adults aged ≥40 years from 12 sites (N=9255), participating in the Burden of Obstructive Lung Disease (BOLD) study, poverty was evaluated using a wealth score (0-10) based on household assets. Obstruction, measured as forced expiratory volume in 1 s (FEV 1 )/forced vital capacity (FVC) (%) after administration of 200 μg salbutamol, and prevalence of FEV 1 /FVCwealth scores ranged from 4 in Blantyre (Malawi) and Kashmir (India) to 10 in Riyadh (Saudi Arabia), and the prevalence of obstruction, from 16% in Kashmir to 3% in Riyadh and Penang (Malaysia). Following adjustments for age and sex, FEV 1 /FVC increased by 0.36% (absolute change) (95%CI: 0.22, 0.49; pwealth score. Adjustments for other confounders reduced this effect to 0.23% (0.11, 0.34), but even this value remained highly significant (pwealth scores explained 38% of the variation in mean FEV 1 /FVC between sites (r 2 =0.385, p=0.031).Airflow obstruction is consistently associated with poverty at individual and community levels across several countries. Copyright ©ERS 2017.

  11. Effect of CGRP and sumatriptan on the BOLD response in visual cortex

    DEFF Research Database (Denmark)

    Asghar, Mohammed Sohail; Hansen, Adam E; Larsson, Henrik B W

    2012-01-01

    To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug......% of the participants reported headache after CGRP. We found no changes in brain activity after CGRP (P = 0.12) or after placebo (P = 0.41). Sumatriptan did not affect brain activity after CGRP (P = 0.71) or after placebo (P = 0.98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual...... sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 µg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after infusion and after 6 mg subcutaneous sumatriptan by functional magnetic resonance imaging (3 T). 77...

  12. Exploiting magnetic resonance angiography imaging improves model estimation of BOLD signal.

    Directory of Open Access Journals (Sweden)

    Zhenghui Hu

    Full Text Available The change of BOLD signal relies heavily upon the resting blood volume fraction ([Formula: see text] associated with regional vasculature. However, existing hemodynamic data assimilation studies pretermit such concern. They simply assign the value in a physiologically plausible range to get over ill-conditioning of the assimilation problem and fail to explore actual [Formula: see text]. Such performance might lead to unreliable model estimation. In this work, we present the first exploration of the influence of [Formula: see text] on fMRI data assimilation, where actual [Formula: see text] within a given cortical area was calibrated by an MR angiography experiment and then was augmented into the assimilation scheme. We have investigated the impact of [Formula: see text] on single-region data assimilation and multi-region data assimilation (dynamic cause modeling, DCM in a classical flashing checkerboard experiment. Results show that the employment of an assumed [Formula: see text] in fMRI data assimilation is only suitable for fMRI signal reconstruction and activation detection grounded on this signal, and not suitable for estimation of unobserved states and effective connectivity study. We thereby argue that introducing physically realistic [Formula: see text] in the assimilation process may provide more reliable estimation of physiological information, which contributes to a better understanding of the underlying hemodynamic processes. Such an effort is valuable and should be well appreciated.

  13. BOLD data representing activation and connectivity for rare no-go versus frequent go cues

    Directory of Open Access Journals (Sweden)

    Harma Meffert

    2016-06-01

    Full Text Available The neural circuitry underlying response control is often studied using go/no-go tasks, in which participants are required to respond as fast as possible to go cues and withhold from responding to no-go stimuli. In the current task, response control was studied using a fully counterbalanced design in which blocks with a low frequency of no-go cues (75% go, 25% no-go were alternated with blocks with a low frequency of go cues (25% go, 75% no-go; see also “Segregating attention from response control when performing a motor inhibition task: Segregating attention from response control” [1]. We applied a whole brain corrected, paired t-test to the data assessing for regions differentially activated by low frequency no-go cues relative to high frequency go cues. In addition, we conducted a generalized psychophysiological interaction analysis on the data using a right inferior frontal gyrus seed region. This region was identified through the BOLD response t-test and was chosen because right inferior gyrus is highly implicated in response inhibition.

  14. Functional evaluation of transplanted kidneys in normal function and acute rejection using BOLD MR imaging

    International Nuclear Information System (INIS)

    Xiao Wenbo; Xu Jingjing; Wang Qindong; Xu Ying; Zhang Minming

    2012-01-01

    In this study, we evaluated a large number of subjects using BOLD MRI to provide more information about oxygen metabolism in the normal function of transplanted kidneys and to distinguish acute graft rejection from normal function kidneys. This study included 122 subjects (20 volunteers, 72 patients with normal functioning transplants, and 21 patients with acute rejection), and 9 patients had normal function grafts received examination while grafts dysfunction occurred within 6 months during the follow-up. The R2* (1/s) values in the cortex and medulla as well as the R2* ratio of the medulla to cortex (R2* ratio of M/C) were recorded. The R2* values of the medulla were higher than those of the cortex in the normal function group and the volunteers which have a steep R2* ratio of M/C. All the R2* values in the acute rejection group were lower than those in the normal function grafts group (P 1.1) is an important reason for keeping clinical normal function.

  15. Altered auditory BOLD response to conspecific birdsong in zebra finches with stuttered syllables.

    Directory of Open Access Journals (Sweden)

    Henning U Voss

    2010-12-01

    Full Text Available How well a songbird learns a song appears to depend on the formation of a robust auditory template of its tutor's song. Using functional magnetic resonance neuroimaging we examine auditory responses in two groups of zebra finches that differ in the type of song they sing after being tutored by birds producing stuttering-like syllable repetitions in their songs. We find that birds that learn to produce the stuttered syntax show attenuated blood oxygenation level-dependent (BOLD responses to tutor's song, and more pronounced responses to conspecific song primarily in the auditory area field L of the avian forebrain, when compared to birds that produce normal song. These findings are consistent with the presence of a sensory song template critical for song learning in auditory areas of the zebra finch forebrain. In addition, they suggest a relationship between an altered response related to familiarity and/or saliency of song stimuli and the production of variant songs with stuttered syllables.

  16. BOLD responses in somatosensory cortices better reflect heat sensation than pain.

    Science.gov (United States)

    Moulton, Eric A; Pendse, Gautam; Becerra, Lino R; Borsook, David

    2012-04-25

    The discovery of cortical networks that participate in pain processing has led to the common generalization that blood oxygen level-dependent (BOLD) responses in these areas indicate the processing of pain. Physical stimuli have fundamental properties that elicit sensations distinguishable from pain, such as heat. We hypothesized that pain intensity coding may reflect the intensity coding of heat sensation during the presentation of thermal stimuli during fMRI. Six 3T fMRI heat scans were collected for 16 healthy subjects, corresponding to perceptual levels of "low innocuous heat," "moderate innocuous heat," "high innocuous heat," "low painful heat," "moderate painful heat," and "high painful heat" delivered by a contact thermode to the face. Subjects rated pain and heat intensity separately after each scan. A general linear model analysis detected different patterns of brain activation for the different phases of the biphasic response to heat. During high painful heat, the early phase was associated with significant anterior insula and anterior cingulate cortex activation. Persistent responses were detected in the right dorsolateral prefrontal cortex and inferior parietal lobule. Only the late phase showed significant correlations with perceptual ratings. Significant heat intensity correlated activation was identified in contralateral primary and secondary somatosensory cortices, motor cortex, and superior temporal lobe. These areas were significantly more related to heat ratings than pain. These results indicate that heat intensity is encoded by the somatosensory cortices, and that pain evaluation may either arise from multimodal evaluative processes, or is a distributed process.

  17. Common brain regions underlying different arithmetic operations as revealed by conjunct fMRI-BOLD activation.

    Science.gov (United States)

    Fehr, Thorsten; Code, Chris; Herrmann, Manfred

    2007-10-03

    The issue of how and where arithmetic operations are represented in the brain has been addressed in numerous studies. Lesion studies suggest that a network of different brain areas are involved in mental calculation. Neuroimaging studies have reported inferior parietal and lateral frontal activations during mental arithmetic using tasks of different complexities and using different operators (addition, subtraction, etc.). Indeed, it has been difficult to compare brain activation across studies because of the variety of different operators and different presentation modalities used. The present experiment examined fMRI-BOLD activity in participants during calculation tasks entailing different arithmetic operations -- addition, subtraction, multiplication and division -- of different complexities. Functional imaging data revealed a common activation pattern comprising right precuneus, left and right middle and superior frontal regions during all arithmetic operations. All other regional activations were operation specific and distributed in prominently frontal, parietal and central regions when contrasting complex and simple calculation tasks. The present results largely confirm former studies suggesting that activation patterns due to mental arithmetic appear to reflect a basic anatomical substrate of working memory, numerical knowledge and processing based on finger counting, and derived from a network originally related to finger movement. We emphasize that in mental arithmetic research different arithmetic operations should always be examined and discussed independently of each other in order to avoid invalid generalizations on arithmetics and involved brain areas.

  18. Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation

    Science.gov (United States)

    Hames, Elizabeth’ C.; Murphy, Brandi; Rajmohan, Ravi; Anderson, Ronald C.; Baker, Mary; Zupancic, Stephen; O’Boyle, Michael; Richman, David

    2016-01-01

    Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20–28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs. PMID:27148020

  19. Visual cortex and auditory cortex activation in early binocularly blind macaques: A BOLD-fMRI study using auditory stimuli.

    Science.gov (United States)

    Wang, Rong; Wu, Lingjie; Tang, Zuohua; Sun, Xinghuai; Feng, Xiaoyuan; Tang, Weijun; Qian, Wen; Wang, Jie; Jin, Lixin; Zhong, Yufeng; Xiao, Zebin

    2017-04-15

    Cross-modal plasticity within the visual and auditory cortices of early binocularly blind macaques is not well studied. In this study, four healthy neonatal macaques were assigned to group A (control group) or group B (binocularly blind group). Sixteen months later, blood oxygenation level-dependent functional imaging (BOLD-fMRI) was conducted to examine the activation in the visual and auditory cortices of each macaque while being tested using pure tones as auditory stimuli. The changes in the BOLD response in the visual and auditory cortices of all macaques were compared with immunofluorescence staining findings. Compared with group A, greater BOLD activity was observed in the bilateral visual cortices of group B, and this effect was particularly obvious in the right visual cortex. In addition, more activated volumes were found in the bilateral auditory cortices of group B than of group A, especially in the right auditory cortex. These findings were consistent with the fact that there were more c-Fos-positive cells in the bilateral visual and auditory cortices of group B compared with group A (p visual cortices of binocularly blind macaques can be reorganized to process auditory stimuli after visual deprivation, and this effect is more obvious in the right than the left visual cortex. These results indicate the establishment of cross-modal plasticity within the visual and auditory cortices. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Larger Neural Responses Produce BOLD Signals That Begin Earlier in Time

    Directory of Open Access Journals (Sweden)

    Serena eThompson

    2014-06-01

    Full Text Available Functional MRI analyses commonly rely on the assumption that the temporal dynamics of hemodynamic response functions (HRFs are independent of the amplitude of the neural signals that give rise to them. The validity of this assumption is particularly important for techniques that use fMRI to resolve sub-second timing distinctions between responses, in order to make inferences about the ordering of neural processes. Whether or not the detailed shape of the HRF is independent of neural response amplitude remains an open question, however. We performed experiments in which we measured responses in primary visual cortex (V1 to large, contrast-reversing checkerboards at a range of contrast levels, which should produce varying amounts of neural activity. Ten subjects (ages 22-52 were studied in each of two experiments using 3 Tesla scanners. We used rapid, 250 msec, temporal sampling (repetition time, or TR and both short and long inter-stimulus interval (ISI stimulus presentations. We tested for a systematic relationship between the onset of the HRF and its amplitude across conditions, and found a strong negative correlation between the two measures when stimuli were separated in time (long- and medium-ISI experiments, but not the short-ISI experiment. Thus, stimuli that produce larger neural responses, as indexed by HRF amplitude, also produced HRFs with shorter onsets. The relationship between amplitude and latency was strongest in voxels with lowest mean-normalized variance (i.e., parenchymal voxels. The onset differences observed in the longer-ISI experiments are likely attributable to mechanisms of neurovascular coupling, since they are substantially larger than reported differences in the onset of action potentials in V1 as a function of response amplitude.

  1. Corrections to the box diagram amplitude due to kaon mass

    International Nuclear Information System (INIS)

    Datta, A.; Kumbhakar, D.

    1985-08-01

    The K 0 -anti-K 0 mixing amplitude is calculated without using the standard zero external momentum approximation. The resulting corrections are numerically significant for the real part of the amplitude. In the imaginary part of the amplitude the effects of similar corrections are less important. Implications for Δmsub(k) and epsilon are discussed. (author)

  2. MHV Vertices And Tree Amplitudes In Gauge Theory

    International Nuclear Information System (INIS)

    Cachazo, Freddy; Svrcek, Peter; Witten, Edward

    2004-01-01

    As an alternative to the usual Feynman graphs, tree amplitudes in Yang-Mills theory can be constructed from tree graphs in which the vertices are tree level MHV scattering amplitudes, continued off shell in a particular fashion. The formalism leads to new and relatively simple formulas for many amplitudes, and can be heuristically derived from twistor space. (author)

  3. Mothers' Maximum Drinks Ever Consumed in 24 Hours Predicts Mental Health Problems in Adolescent Offspring

    Science.gov (United States)

    Malone, Stephen M.; McGue, Matt; Iacono, William G.

    2010-01-01

    Background: The maximum number of alcoholic drinks consumed in a single 24-hr period is an alcoholism-related phenotype with both face and empirical validity. It has been associated with severity of withdrawal symptoms and sensitivity to alcohol, genes implicated in alcohol metabolism, and amplitude of a measure of brain activity associated with…

  4. EEG-informed fMRI analysis during a hand grip task: estimating the relationship between EEG rhythms and the BOLD signal

    Directory of Open Access Journals (Sweden)

    Roberta eSclocco

    2014-04-01

    Full Text Available In the last decade, an increasing interest has arisen in investigating the relationship between the electrophysiological and hemodynamic measurements of brain activity, such as EEG and (BOLD fMRI. In particular, changes in BOLD have been shown to be associated with changes in the spectral profile of neural activity, rather than with absolute power. Concurrently, recent findings showed that different EEG rhythms are independently related to changes in the BOLD signal: therefore, it would be important to distinguish between the contributions of the different EEG rhythms to BOLD fluctuations when modeling the relationship between the two signals. Here we propose a method to perform EEG-informed fMRI analysis, in which the EEG regressors take into account both the changes in the spectral profile and the rhythms distinction. We applied it to EEG-fMRI data during a hand grip task in healthy subjects, and compared the results with those obtained by two existing models found in literature. Our results showed that the proposed method better captures the correlations between BOLD signal and EEG rhythms modulations, identifying task-related, well localized activated volumes. Furthermore, we showed that including among the regressors also EEG rhythms not primarily involved in the task enhances the performance of the analysis, even when only correlations with BOLD signal and specific EEG rhythms are explored.

  5. Maximum entropy principal for transportation

    International Nuclear Information System (INIS)

    Bilich, F.; Da Silva, R.

    2008-01-01

    In this work we deal with modeling of the transportation phenomenon for use in the transportation planning process and policy-impact studies. The model developed is based on the dependence concept, i.e., the notion that the probability of a trip starting at origin i is dependent on the probability of a trip ending at destination j given that the factors (such as travel time, cost, etc.) which affect travel between origin i and destination j assume some specific values. The derivation of the solution of the model employs the maximum entropy principle combining a priori multinomial distribution with a trip utility concept. This model is utilized to forecast trip distributions under a variety of policy changes and scenarios. The dependence coefficients are obtained from a regression equation where the functional form is derived based on conditional probability and perception of factors from experimental psychology. The dependence coefficients encode all the information that was previously encoded in the form of constraints. In addition, the dependence coefficients encode information that cannot be expressed in the form of constraints for practical reasons, namely, computational tractability. The equivalence between the standard formulation (i.e., objective function with constraints) and the dependence formulation (i.e., without constraints) is demonstrated. The parameters of the dependence-based trip-distribution model are estimated, and the model is also validated using commercial air travel data in the U.S. In addition, policy impact analyses (such as allowance of supersonic flights inside the U.S. and user surcharge at noise-impacted airports) on air travel are performed.

  6. Last Glacial Maximum Salinity Reconstruction

    Science.gov (United States)

    Homola, K.; Spivack, A. J.

    2016-12-01

    It has been previously demonstrated that salinity can be reconstructed from sediment porewater. The goal of our study is to reconstruct high precision salinity during the Last Glacial Maximum (LGM). Salinity is usually determined at high precision via conductivity, which requires a larger volume of water than can be extracted from a sediment core, or via chloride titration, which yields lower than ideal precision. It has been demonstrated for water column samples that high precision density measurements can be used to determine salinity at the precision of a conductivity measurement using the equation of state of seawater. However, water column seawater has a relatively constant composition, in contrast to porewater, where variations from standard seawater composition occur. These deviations, which affect the equation of state, must be corrected for through precise measurements of each ion's concentration and knowledge of apparent partial molar density in seawater. We have developed a density-based method for determining porewater salinity that requires only 5 mL of sample, achieving density precisions of 10-6 g/mL. We have applied this method to porewater samples extracted from long cores collected along a N-S transect across the western North Atlantic (R/V Knorr cruise KN223). Density was determined to a precision of 2.3x10-6 g/mL, which translates to salinity uncertainty of 0.002 gms/kg if the effect of differences in composition is well constrained. Concentrations of anions (Cl-, and SO4-2) and cations (Na+, Mg+, Ca+2, and K+) were measured. To correct salinities at the precision required to unravel LGM Meridional Overturning Circulation, our ion precisions must be better than 0.1% for SO4-/Cl- and Mg+/Na+, and 0.4% for Ca+/Na+, and K+/Na+. Alkalinity, pH and Dissolved Inorganic Carbon of the porewater were determined to precisions better than 4% when ratioed to Cl-, and used to calculate HCO3-, and CO3-2. Apparent partial molar densities in seawater were

  7. Maximum Parsimony on Phylogenetic networks

    Science.gov (United States)

    2012-01-01

    Background Phylogenetic networks are generalizations of phylogenetic trees, that are used to model evolutionary events in various contexts. Several different methods and criteria have been introduced for reconstructing phylogenetic trees. Maximum Parsimony is a character-based approach that infers a phylogenetic tree by minimizing the total number of evolutionary steps required to explain a given set of data assigned on the leaves. Exact solutions for optimizing parsimony scores on phylogenetic trees have been introduced in the past. Results In this paper, we define the parsimony score on networks as the sum of the substitution costs along all the edges of the network; and show that certain well-known algorithms that calculate the optimum parsimony score on trees, such as Sankoff and Fitch algorithms extend naturally for networks, barring conflicting assignments at the reticulate vertices. We provide heuristics for finding the optimum parsimony scores on networks. Our algorithms can be applied for any cost matrix that may contain unequal substitution costs of transforming between different characters along different edges of the network. We analyzed this for experimental data on 10 leaves or fewer with at most 2 reticulations and found that for almost all networks, the bounds returned by the heuristics matched with the exhaustively determined optimum parsimony scores. Conclusion The parsimony score we define here does not directly reflect the cost of the best tree in the network that displays the evolution of the character. However, when searching for the most parsimonious network that describes a collection of characters, it becomes necessary to add additional cost considerations to prefer simpler structures, such as trees over networks. The parsimony score on a network that we describe here takes into account the substitution costs along the additional edges incident on each reticulate vertex, in addition to the substitution costs along the other edges which are

  8. Non-supersymmetric loop amplitudes and MHV vertices

    International Nuclear Information System (INIS)

    Bedford, James; Brandhuber, Andreas; Spence, Bill; Travaglini, Gabriele

    2005-01-01

    We show how the MHV diagram description of Yang-Mills theories can be used to study non-supersymmetric loop amplitudes. In particular, we derive a compact expression for the cut-constructible part of the general one-loop MHV multi-gluon scattering amplitude in pure Yang-Mills theory. We show that in special cases this expression reduces to known amplitudes-the amplitude with adjacent negative-helicity gluons, and the five gluon non-adjacent amplitude. Finally, we briefly discuss the twistor space interpretation of our result

  9. Phase and amplitude detection system for the Stanford Linear Accelerator

    International Nuclear Information System (INIS)

    Fox, J.D.; Schwarz, H.D.

    1983-01-01

    A computer controlled phase and amplitude detection system to measure and stabilize the rf power sources in the Stanford Linear Accelerator is described. This system measures the instantaneous phase and amplitude of a 1 microsecond 2856 MHz rf pulse and will be used for phase feedback control and for amplitude and phase jitter detection. This paper discusses the measurement system performance requirements for the operation of the Stanford Linear Collider, and the design and implementation of the phase and amplitude detection system. The fundamental software algorithms used in the measurement are described, as is the performance of the prototype phase and amplitude detector system

  10. Effects of amplitude modulation on perception of wind turbine noise

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Ki Seop; Lee, Soo Gab; Gwak, Doo Young [Dept. of Mechanical and Aerospace Engineering, Seoul National University, Seoul (Korea, Republic of); Seong, Yeol Wan [Ammunition Engineering Team, Defense Agency for Technology and Quality, Daejeon (Korea, Republic of); Lee, Seung Hoon [Aerodynamics Research Team, Korea Aerospace Research Institute, Daejeon (Korea, Republic of); Hong, Ji Young [Transportation Environmental Research Team, Green Transport and Logistics Institute, Korea Railroad Research Institute, Uiwang (Korea, Republic of)

    2016-10-15

    Wind turbine noise is considered to be easily detectable and highly annoying at relatively lower sound levels than other noise sources. Many previous studies attributed this characteristic to amplitude modulation. However, it is unclear whether amplitude modulation is the main cause of these properties of wind turbine noise. Therefore, the aim of the current study is to identify the relationship between amplitude modulation and these two properties of wind turbine noise. For this investigation, two experiments were conducted. In the first experiment, 12 participants determined the detection thresholds of six target sounds in the presence of background noise. In the second experiment, 12 participants matched the loudness of modified sounds without amplitude modulation to that of target sounds with amplitude modulation. The results showed that the detection threshold was lowered as the modulation depth increased; additionally, sounds with amplitude modulation had higher subjective loudness than those without amplitude modulation.

  11. Effects of amplitude modulation on perception of wind turbine noise

    International Nuclear Information System (INIS)

    Yoon, Ki Seop; Lee, Soo Gab; Gwak, Doo Young; Seong, Yeol Wan; Lee, Seung Hoon; Hong, Ji Young

    2016-01-01

    Wind turbine noise is considered to be easily detectable and highly annoying at relatively lower sound levels than other noise sources. Many previous studies attributed this characteristic to amplitude modulation. However, it is unclear whether amplitude modulation is the main cause of these properties of wind turbine noise. Therefore, the aim of the current study is to identify the relationship between amplitude modulation and these two properties of wind turbine noise. For this investigation, two experiments were conducted. In the first experiment, 12 participants determined the detection thresholds of six target sounds in the presence of background noise. In the second experiment, 12 participants matched the loudness of modified sounds without amplitude modulation to that of target sounds with amplitude modulation. The results showed that the detection threshold was lowered as the modulation depth increased; additionally, sounds with amplitude modulation had higher subjective loudness than those without amplitude modulation

  12. The pulsed amplitude unit for the SLC

    International Nuclear Information System (INIS)

    Rolfe, J.; Browne, M.J.; Jobe, R.K.

    1987-02-01

    There is a recurring requirement in the SLC for the control of devices such as magnets, phase shifters, and attenuators on a beam-by-beam basis. The Pulsed Amplitude Unit (PAU) is a single width CAMAC module developed for this purpose. It provides digitally programmed analog output voltages on a beam-by-beam basis. Up to 32 preprogrammed values of output voltage are available from the single analog output of the module, and any of these values can be associated with any of the 256 possible SLC beam definitions. A 12-bit Analog-to-Digital Converter (ADC) digitizes an analog input signal at the appropriate beam time and stores it in a buffer memory. This feature is normally used to monitor the response of the device being controlled by the PAU at each beam time. Initial application of the PAU is a part of the system that controls the output of Klystrons in the SLC. The PAU combines several different functions in a single module. In order to accommodate these functions in a single width CAMAC module, field programmed logic is used extensively. Field Programmable Logic Arrays, Programmed Array Logic, and a Field Programmable Logic Sequencer are employed

  13. Gearbox Vibration Signal Amplitude and Frequency Modulation

    Directory of Open Access Journals (Sweden)

    Fakher Chaari

    2012-01-01

    Full Text Available Gearboxes usually run under fluctuating load conditions during service, however most of papers available in the literature describe models of gearboxes under stationary load conditions. Main task of published papers is fault modeling for their detection. Considering real situation from industry, the assumption of stationarity of load conditions cannot be longer kept. Vibration signals issued from monitoring in maintenance operations differ from mentioned models (due to load non-stationarity and may be difficult to analyze which lead to erroneous diagnosis of the system. The objective of this paper is to study the influence of time varying load conditions on a gearbox dynamic behavior. To investigate this, a simple spur gear system without defects is modeled. It is subjected to a time varying load. The speed-torque characteristic of the driving motor is considered. The load variation induces speed variation, which causes a variation in the gearmesh stiffness period. Computer simulation shows deep amplitude modulations with sidebands that don't differ from those obtained when there is a defective tooth. In order to put in evidence the time varying load effects, Short Time Fourier Transform and then Smoothed Wigner-Ville distribution are used. Results show that the last one is well suited for the studied case.

  14. Electroweak amplitudes in chiral quark models

    International Nuclear Information System (INIS)

    Fiolhais, Manuel

    2004-01-01

    After referring to some basic features of chiral models for baryons, with quarks and mesons, we describe how to construct model states representing physical baryons. We consider soliton models such as the Linear Sigma Model or the Chromodielectric Model, and bag models such as the Cloudy Bag Model. These models are solved approximately using variational approaches whose starting point is a mean-field description. We go beyond the mean-field description by introducing quantum fluctuations in the mesonic degrees of freedom. This is achieved, in a first step, by using a quantum state to represent meson clouds and, secondly, by performing an angular momentum and isospin projection from the mean-field state (actually a coherent state). Model states for baryons (nucleon, Delta, Roper) constructed in this way are used to determine several physical properties. I this seminar we paid a particular attention to the nucleon-delta electromagnetic and weak transition, presenting the model predictions for the electromagnetic and axial amplitudes

  15. Nonlinear amplitude dynamics in flagellar beating.

    Science.gov (United States)

    Oriola, David; Gadêlha, Hermes; Casademunt, Jaume

    2017-03-01

    The physical basis of flagellar and ciliary beating is a major problem in biology which is still far from completely understood. The fundamental cytoskeleton structure of cilia and flagella is the axoneme, a cylindrical array of microtubule doublets connected by passive cross-linkers and dynein motor proteins. The complex interplay of these elements leads to the generation of self-organized bending waves. Although many mathematical models have been proposed to understand this process, few attempts have been made to assess the role of dyneins on the nonlinear nature of the axoneme. Here, we investigate the nonlinear dynamics of flagella by considering an axonemal sliding control mechanism for dynein activity. This approach unveils the nonlinear selection of the oscillation amplitudes, which are typically either missed or prescribed in mathematical models. The explicit set of nonlinear equations are derived and solved numerically. Our analysis reveals the spatio-temporal dynamics of dynein populations and flagellum shape for different regimes of motor activity, medium viscosity and flagellum elasticity. Unstable modes saturate via the coupling of dynein kinetics and flagellum shape without the need of invoking a nonlinear axonemal response. Hence, our work reveals a novel mechanism for the saturation of unstable modes in axonemal beating.

  16. An amplitude modulated radio frequency plasma generator

    Science.gov (United States)

    Lei, Fan; Li, Xiaoping; Liu, Yanming; Liu, Donglin; Yang, Min; Xie, Kai; Yao, Bo

    2017-04-01

    A glow discharge plasma generator and diagnostic system has been developed to study the effects of rapidly variable plasmas on electromagnetic wave propagation, mimicking the plasma sheath conditions encountered in space vehicle reentry. The plasma chamber is 400 mm in diameter and 240 mm in length, with a 300-mm-diameter unobstructed clear aperture. Electron densities produced are in the mid 1010 electrons/cm3. An 800 W radio frequency (RF) generator is capacitively coupled through an RF matcher to an internally cooled stainless steel electrode to form the plasma. The RF power is amplitude modulated by a waveform generator that operates at different frequencies. The resulting plasma contains electron density modulations caused by the varying power levels. A 10 GHz microwave horn antenna pair situated on opposite sides of the chamber serves as the source and detector of probe radiation. The microwave power feed to the source horn is split and one portion is sent directly to a high-speed recording oscilloscope. On mixing this with the signal from the pickup horn antenna, the plasma-induced phase shift between the two signals gives the path-integrated electron density with its complete time dependent variation. Care is taken to avoid microwave reflections and extensive shielding is in place to minimize electronic pickup. Data clearly show the low frequency modulation of the electron density as well as higher harmonics and plasma fluctuations.

  17. Open string topological amplitudes and gaugino masses

    International Nuclear Information System (INIS)

    Antoniadis, I.; Narain, K.S.; Taylor, T.R.

    2005-09-01

    We discuss the moduli-dependent couplings of the higher derivative F-terms (TrW 2 ) h-1 , where W is the gauge N =1 chiral superfield. They are determined by the genus zero topological partition function F (0,h) , on a world-sheet with h boundaries. By string duality, these terms are also related to heterotic topological amplitudes studied in the past, with the topological twist applied only in the left-moving supersymmetric sector of the internal N =(2,0) superconformal field theory. The holomorphic anomaly of these couplings relates them to terms of the form Π n (TrW 2 ) h-2 , where Π's represent chiral projections of non-holomorphic functions of chiral superfields. An important property of these couplings is that they violate R-symmetry for h ≥ 3. As a result, once supersymmetry is broken by D-term expectation values, (TrW 2 ) 2 generates gaugino masses that can be hierarchically smaller than the scalar masses, behaving as m 1/2 ∼ m 0 4 in string units. Similarly, ΠTrW 2 generates Dirac masses for non-chiral brane fermions, of the same order of magnitude. This mechanism can be used for instance to obtain fermion masses at the TeV scale for scalar masses as high as m 0 ∼ O (10 13 ) GeV. We present explicit examples in toroidal string compactifications with intersecting D-branes. (author)

  18. Casimir amplitudes in topological quantum phase transitions.

    Science.gov (United States)

    Griffith, M A; Continentino, M A

    2018-01-01

    Topological phase transitions constitute a new class of quantum critical phenomena. They cannot be described within the usual framework of the Landau theory since, in general, the different phases cannot be distinguished by an order parameter, neither can they be related to different symmetries. In most cases, however, one can identify a diverging length at these topological transitions. This allows us to describe them using a scaling approach and to introduce a set of critical exponents that characterize their universality class. Here we consider some relevant models of quantum topological transitions associated with well-defined critical exponents that are related by a quantum hyperscaling relation. We extend to these models a finite-size scaling approach based on techniques for calculating the Casimir force in electromagnetism. This procedure allows us to obtain universal Casimir amplitudes at their quantum critical points. Our results verify the validity of finite-size scaling in these systems and confirm the values of the critical exponents obtained previously.

  19. Effective anisotropy through traveltime and amplitude matching

    KAUST Repository

    Wang, Hui

    2014-08-05

    Introducing anisotropy to seismic wave propagation reveals more realistic physics of our Earth\\'s subsurface as compared to the isotropic assumption. However wavefield modeling, the engine of seismic inverse problems, in anisotropic media still suffers from computational burdens, in particular with complex anisotropy such as transversely isotropic (TI) and Orthorhombic anisotropy. We develop effective isotropic velocity and density models to package the effects of anisotropy such that the wave propagation behavior using these effective models approximate those of the original anisotropic model. We build these effective models through the high frequency asymptotic approximation based on the eikonal and transport equations. We match the geometrical behavior of the wave-fields, given by traveltimes, from the anisotropic and isotropic eikonal equations. This matching yields the effective isotropic velocity that approximates the kinematics of the anisotropic wavefield. Equivalently, we calculate the effective densities by equating the anisotropic and isotropic transport equations. The effective velocities and densities are then fed into the isotropic acoustic variable density wave equation to obtain cheaper anisotropic wavefields. We justify our approach by testing it on an elliptical anisotropic model. The numerical results demonstrate a good matching of both traveltime and amplitude between anisotropic and effective isotropic wavefields.

  20. The pulsed amplitude unit for the SLC

    International Nuclear Information System (INIS)

    Rolfe, J.; Browne, M.J.; Jobe, R.K.

    1987-01-01

    There is a recurring requirement in the SLC for the control of devices such as magnets, phase shifters, and attenuators on a beam-by-beam basis. The Pulsed Amplitude Unit (PAU) is a single width CAMAC module developed for this purpose. It provides digitally programmed analog output voltages on a beam-by-beam basis. Up to 32 preprogrammed values of output voltage are available from the single analog output of the module, and any of these values can be associated with any of the 256 possible SLC beam definitions. A 12-bit Analog-to-Digital converter (ADC) digitizes an analog input signal at the appropriate beam time and stores it in a buffer memory. This feature is normally used to monitor the response of the device being controlled by the PAU at each beam time. Initial application of the PAU at is as part of the system that controls the output of Klystorns in the SLC. The PAU combines several different functions in a single module. In order to accommodate these functions in a single width CAMAC module, field programmed logic is used extensively. Field Programmable Logic Arrays, Programmed Array Logic, and a Field Programmable Logic Sequencer are employed

  1. Complex amplitude reconstruction by iterative amplitude-phase retrieval algorithm with reference

    Science.gov (United States)

    Shen, Cheng; Guo, Cheng; Tan, Jiubin; Liu, Shutian; Liu, Zhengjun

    2018-06-01

    Multi-image iterative phase retrieval methods have been successfully applied in plenty of research fields due to their simple but efficient implementation. However, there is a mismatch between the measurement of the first long imaging distance and the sequential interval. In this paper, an amplitude-phase retrieval algorithm with reference is put forward without additional measurements or priori knowledge. It gets rid of measuring the first imaging distance. With a designed update formula, it significantly raises the convergence speed and the reconstruction fidelity, especially in phase retrieval. Its superiority over the original amplitude-phase retrieval (APR) method is validated by numerical analysis and experiments. Furthermore, it provides a conceptual design of a compact holographic image sensor, which can achieve numerical refocusing easily.

  2. BOLD/VENTURE-4, Reactor Analysis System with Sensitivity and Burnup

    International Nuclear Information System (INIS)

    1998-01-01

    1 - Description of program or function: The system of codes can be used to solve nuclear reactor core static neutronics and reactor history exposure problems. BOLD/VENTURE-4: First order perturbation and time-dependent sensitivity theories can be applied. Control rod positioning may be modeled explicitly and refueling treated with repositioning and recycle. Special capability is coded to model the continuously fueled core and to solve the importance and dominant harmonics problems. The modules of the code system are: VENTNEUT: VENTURE neutronics module; DRIVER and CONTRL: Control module; BURNER: Exposure calculation for reactor core analysis; FILEDTOR: File editor; INPROSER: Input processor; EXPOSURE: BURNER code module; REACRATE: Reaction rate calculation; CNTRODPO: Control rod positioning; FUELMANG: Fuel management positioning and accounting; PERTUBAT: Perturbation reactivity importance analyses; sensitivity analysis; DEPTHMOD: Static and time-dependent perturbation sensitivity analysis. The special processors are: DVENTR: Handles the input to the VENTURE module; DCMACR: Converts CITATION macroscopic cross sections to microscopic cross sections; DCRSPR: Produces input for the CROSPROS module; DUTLIN: Adds or replaces problem input data without exiting the program; DENMAN: Repositions fuel; DMISLY: Miscellaneous tasks. Standard interface files between modules are binary sequential files that follow a standardized format. VENTURE-PC: The microcomputer version is a subset of the mainframe version. The modules and special processors which are not part of VENTURE-PC are: REACRATE, CNTRODPO, PERTUBAT, FUELMANG, DEPTHMOD, DMISLY. 2 - method of solution: BOLD-VENTURE-4: The neutronics problems are solved by applying the multigroup diffusion theory representation of neutron transport applying an over-relaxation inner iteration, outer iteration scheme. Special modeling is used or source correction is done during iteration to solve importance and harmonics problems. No

  3. Development of a parallel zoomed EVI sequence for high temporal resolution analysis of the BOLD response

    International Nuclear Information System (INIS)

    Rabrait, C.

    2006-01-01

    The hemodynamic impulse response to any short stimulus typically lasts around 20 seconds. Thus, the detection of the Blood Oxygenation Level Dependent (BOLD) effect is usually performed using a 2D Echo Planar Imaging (EPI) sequence, with repetition times on the order of 1 or 2 seconds. This temporal resolution is generally enough for detection purposes. Nevertheless, when trying to accurately estimate the hemodynamic response functions (HRF), higher scanning rates represent a real advantage. Thus, in order to reach a temporal resolution around 200 ms, we developed a new acquisition method, based on Echo Volumar Imaging and 2D parallel acquisition (1). Echo Volumar Imaging (EVI) has been proposed in 1977 by Mansfield (2). EVI intrinsically possesses a lot of advantages for functional neuroimaging, as a 3 D single shot acquisition method. Nevertheless, to date, only a few applications have been reported (3, 4). Actually, very restricting hardware requirements make EVI difficult to perform in satisfactory experimental conditions, even today. The critical point in EVI is the echo train duration, which is longer than in EPI, due to 3D acquisition. Indeed, at equal field of view and spatial resolutions, EVI echo train duration must be approximately equal to EPI echo train duration multiplied by the number of slices acquired in EPI. Consequently, EVI is much more sensitive than EPI to geometric distortions, which are related to phase errors, and also to signal losses, which are due to long echo times (TE). Thus, a first improvement has been brought by 'zoomed' or 'localized' EVI (5), which allows to focus on a small volume of interest and thus limit echo train durations compared to full FOV acquisitions.To reduce echo train durations, we chose to apply parallel acquisition. Moreover, since EVI is a 3D acquisition method, we are able to perform parallel acquisition and SENSE reconstruction along the two phase directions (6). The R = 4 under-sampling consists in the

  4. Transversity Amplitudes in Hypercharge Exchange Processes; Amplitudes de transversidad en procesos de intercambio de hipercarga

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar Benitez de Lugo, M.

    1979-07-01

    In this work we present several techniques developed for the extraction of the. Transversity amplitudes governing quasi two-body meson baryon reactions with hypercharge exchange. We review the methods used In processes having a pure spin configuration, as well as the more relevant results obtained with data from K{sup p} and Tp interactions at intermediate energies. The predictions of the additive quark model and the ones following from exchange degeneracy and etoxicity are discussed. We present a formalism for amplitude analysis developed for reactions with mixed spin configurations and discuss the methods of parametric estimation of the moduli and phases of.the amplitudes, as well as the various tests employed to check the goodness of the fits. The calculation of the generalized joint density matrices is given and we propose a method based on the generalization of the idea of multipole moments, which allows to investigate the structure of the decay angular correlations and establishes the quality of the fits and the validity of the simplifying assumptions currently used in this type of studies. (Author) 43 refs.

  5. Reliable quantification of BOLD fMRI cerebrovascular reactivity despite poor breath-hold performance.

    Science.gov (United States)

    Bright, Molly G; Murphy, Kevin

    2013-12-01

    Cerebrovascular reactivity (CVR) can be mapped using BOLD fMRI to provide a clinical insight into vascular health that can be used to diagnose cerebrovascular disease. Breath-holds are a readily accessible method for producing the required arterial CO2 increases but their implementation into clinical studies is limited by concerns that patients will demonstrate highly variable performance of breath-hold challenges. This study assesses the repeatability of CVR measurements despite poor task performance, to determine if and how robust results could be achieved with breath-holds in patients. Twelve healthy volunteers were scanned at 3 T. Six functional scans were acquired, each consisting of 6 breath-hold challenges (10, 15, or 20 s duration) interleaved with periods of paced breathing. These scans simulated the varying breath-hold consistency and ability levels that may occur in patient data. Uniform ramps, time-scaled ramps, and end-tidal CO2 data were used as regressors in a general linear model in order to measure CVR at the grey matter, regional, and voxelwise level. The intraclass correlation coefficient (ICC) quantified the repeatability of the CVR measurement for each breath-hold regressor type and scale of interest across the variable task performances. The ramp regressors did not fully account for variability in breath-hold performance and did not achieve acceptable repeatability (ICC0.4). Further analysis of intra-subject CVR variability across the brain (ICCspatial and voxelwise correlation) supported the use of end-tidal CO2 data to extract robust whole-brain CVR maps, despite variability in breath-hold performance. We conclude that the incorporation of end-tidal CO2 monitoring into scanning enables robust, repeatable measurement of CVR that makes breath-hold challenges suitable for routine clinical practice. © 2013.

  6. Cerebral Asymmetry of fMRI-BOLD Responses to Visual Stimulation.

    Directory of Open Access Journals (Sweden)

    Anders Hougaard

    Full Text Available Hemispheric asymmetry of a wide range of functions is a hallmark of the human brain. The visual system has traditionally been thought of as symmetrically distributed in the brain, but a growing body of evidence has challenged this view. Some highly specific visual tasks have been shown to depend on hemispheric specialization. However, the possible lateralization of cerebral responses to a simple checkerboard visual stimulation has not been a focus of previous studies. To investigate this, we performed two sessions of blood-oxygenation level dependent (BOLD functional magnetic resonance imaging (fMRI in 54 healthy subjects during stimulation with a black and white checkerboard visual stimulus. While carefully excluding possible non-physiological causes of left-to-right bias, we compared the activation of the left and the right cerebral hemispheres and related this to grey matter volume, handedness, age, gender, ocular dominance, interocular difference in visual acuity, as well as line-bisection performance. We found a general lateralization of cerebral activation towards the right hemisphere of early visual cortical areas and areas of higher-level visual processing, involved in visuospatial attention, especially in top-down (i.e., goal-oriented attentional processing. This right hemisphere lateralization was partly, but not completely, explained by an increased grey matter volume in the right hemisphere of the early visual areas. Difference in activation of the superior parietal lobule was correlated with subject age, suggesting a shift towards the left hemisphere with increasing age. Our findings suggest a right-hemispheric dominance of these areas, which could lend support to the generally observed leftward visual attentional bias and to the left hemifield advantage for some visual perception tasks.

  7. The Role of Oxytocin in Parenting and as Augmentative Pharmacotherapy: Critical Issues and Bold Conjectures.

    Science.gov (United States)

    van IJzendoorn, M H; Bakermans-Kranenburg, M J

    2016-08-01

    Despite the sometimes heated debate about the validity of human oxytocin studies, experimental oxytocin research with intranasal administration is a growing field with promising preliminary findings. The effects of intranasally administered oxytocin compared to placebo on brain neural activity have been supported in animal studies and in human studies of neural resting state. In several studies, oxytocin sniffs have been shown to lead to down-regulation of amygdala activation in response to infant attachment vocalisations. Meta-analytic evidence shows that oxytocin enhances the salience of (emotional) stimuli, lowers stress and arousal, and elevates empathic concern and tender care, in particular for offspring and in-group members. Less firm evidence points at the amnestic effects of oxytocin. We also note that the average effect sizes of oxytocin experiments are small to modest, and that most studies include a small number of subjects and thus are seriously underpowered, which implies a high risk for publication bias and nonreplicability. Nevertheless, we argue that the power of within-subjects experiments with oxytocin has been underestimated. Much more work is needed, however, to create a firm knowledge base of the neural and behavioural effects of oxytocin. Human oxytocin research is still taking place in the context of discovery, in which bold conjectures are being generated. In the context of justification, these conjectures should subsequently be subjected to stringent attempts at refutations before we jump to theoretical or clinical conclusions. For this context of justification, we propose a multisite multiple replications project on the social stimuli salience enhancing effect of oxytocin. Clinical application of oxytocin is premature. Meta-analytically, the use of oxytocin in clinical groups tends to show only effectiveness in changing symptomatology in individuals with autism spectrum disorders but, even then, it is not yet a validated therapy and its

  8. Airflow Obstruction and Use of Solid Fuels for Cooking or Heating: BOLD Results.

    Science.gov (United States)

    Amaral, André F S; Patel, Jaymini; Kato, Bernet S; Obaseki, Daniel O; Lawin, Hervé; Tan, Wan C; Juvekar, Sanjay K; Harrabi, Imed; Studnicka, Michael; Wouters, Emiel F M; Loh, Li-Cher; Bateman, Eric D; Mortimer, Kevin; Buist, A Sonia; Burney, Peter G J

    2017-09-12

    Evidence supporting the association of COPD or airflow obstruction with use of solid fuels is conflicting and inconsistent. To assess the association of airflow obstruction with self-reported use of solid fuels for cooking or heating. We analysed 18,554 adults from the BOLD study, who had provided acceptable post-bronchodilator spirometry measurements and information on use of solid fuels. The association of airflow obstruction with use of solid fuels for cooking or heating was assessed by sex, within each site, using regression analysis. Estimates were stratified by national income and meta-analysed. We carried out similar analyses for spirometric restriction, chronic cough and chronic phlegm. We found no association between airflow obstruction and use of solid fuels for cooking or heating (ORmen=1.20, 95%CI 0.94-1.53; ORwomen=0.88, 95%CI 0.67-1.15). This was true for low/middle and high income sites. Among never smokers there was also no evidence of an association of airflow obstruction with use of solid fuels (ORmen=1.00, 95%CI 0.57-1.76; ORwomen=1.00, 95%CI 0.76-1.32). Overall, we found no association of spirometric restriction, chronic cough or chronic phlegm with the use of solid fuels. However, we found that chronic phlegm was more likely to be reported among female never smokers and those who had been exposed for ≥20 years. Airflow obstruction assessed from post-bronchodilator spirometry was not associated with use of solid fuels for cooking or heating.

  9. Graph Theoretical Analysis of BOLD Functional Connectivity during Human Sleep without EEG Monitoring.

    Directory of Open Access Journals (Sweden)

    Jun Lv

    Full Text Available Functional brain networks of human have been revealed to have small-world properties by both analyzing electroencephalogram (EEG and functional magnetic resonance imaging (fMRI time series.In our study, by using graph theoretical analysis, we attempted to investigate the changes of paralimbic-limbic cortex between wake and sleep states. Ten healthy young people were recruited to our experiment. Data from 2 subjects were excluded for the reason that they had not fallen asleep during the experiment. For each subject, blood oxygen level dependency (BOLD images were acquired to analyze brain network, and peripheral pulse signals were obtained continuously to identify if the subject was in sleep periods. Results of fMRI showed that brain networks exhibited stronger small-world characteristics during sleep state as compared to wake state, which was in consistent with previous studies using EEG synchronization. Moreover, we observed that compared with wake state, paralimbic-limbic cortex had less connectivity with neocortical system and centrencephalic structure in sleep.In conclusion, this is the first study, to our knowledge, has observed that small-world properties of brain functional networks altered when human sleeps without EEG synchronization. Moreover, we speculate that paralimbic-limbic cortex organization owns an efficient defense mechanism responsible for suppressing the external environment interference when humans sleep, which is consistent with the hypothesis that the paralimbic-limbic cortex may be functionally disconnected from brain regions which directly mediate their interactions with the external environment. Our findings also provide a reasonable explanation why stable sleep exhibits homeostasis which is far less susceptible to outside world.

  10. Two-dimensional maximum entropy image restoration

    International Nuclear Information System (INIS)

    Brolley, J.E.; Lazarus, R.B.; Suydam, B.R.; Trussell, H.J.

    1977-07-01

    An optical check problem was constructed to test P LOG P maximum entropy restoration of an extremely distorted image. Useful recovery of the original image was obtained. Comparison with maximum a posteriori restoration is made. 7 figures

  11. Reproductive cycles in tropical intertidal gastropods are timed around tidal amplitude cycles.

    Science.gov (United States)

    Collin, Rachel; Kerr, Kecia; Contolini, Gina; Ochoa, Isis

    2017-08-01

    Reproduction in iteroparous marine organisms is often timed with abiotic cycles and may follow lunar, tidal amplitude, or daily cycles. Among intertidal marine invertebrates, decapods are well known to time larval release to coincide with large amplitude nighttime tides, which minimizes the risk of predation. Such bimonthly cycles have been reported for few other intertidal invertebrates. We documented the reproduction of 6 gastropod species from Panama to determine whether they demonstrate reproductive cycles, whether these cycles follow a 2-week cycle, and whether cycles are timed so that larval release occurs during large amplitude tides. Two of the species ( Crepidula cf. marginalis and Nerita scabricosta ) showed nonuniform reproduction, but without clear peaks in timing relative to tidal or lunar cycles. The other 4 species show clear peaks in reproduction occurring every 2 weeks. In 3 of these species ( Cerithideopsis carlifornica var. valida, Littoraria variegata , and Natica chemnitzi ), hatching occurred within 4 days of the maximum amplitude tides. Siphonaria palmata exhibit strong cycles, but reproduction occurred during the neap tides. Strong differences in the intensity of reproduction of Cerithideopsis carlifornica , and in particular, Littoraria variegata , between the larger and smaller spring tides of a lunar month indicate that these species time reproduction with the tidal amplitude cycle rather than the lunar cycle. For those species that reproduce during both the wet and dry seasons, we found that reproductive timing did not differ between seasons despite strong differences in temperature and precipitation. Overall, we found that most (4/6) species have strong reproductive cycles synchronized with the tidal amplitude cycle and that seasonal differences in abiotic factors do not alter these cycles.

  12. Cerebral Metabolic Rate of Oxygen (CMRO2 ) Mapping by Combining Quantitative Susceptibility Mapping (QSM) and Quantitative Blood Oxygenation Level-Dependent Imaging (qBOLD).

    Science.gov (United States)

    Cho, Junghun; Kee, Youngwook; Spincemaille, Pascal; Nguyen, Thanh D; Zhang, Jingwei; Gupta, Ajay; Zhang, Shun; Wang, Yi

    2018-03-07

    To map the cerebral metabolic rate of oxygen (CMRO 2 ) by estimating the oxygen extraction fraction (OEF) from gradient echo imaging (GRE) using phase and magnitude of the GRE data. 3D multi-echo gradient echo imaging and perfusion imaging with arterial spin labeling were performed in 11 healthy subjects. CMRO 2 and OEF maps were reconstructed by joint quantitative susceptibility mapping (QSM) to process GRE phases and quantitative blood oxygen level-dependent (qBOLD) modeling to process GRE magnitudes. Comparisons with QSM and qBOLD alone were performed using ROI analysis, paired t-tests, and Bland-Altman plot. The average CMRO 2 value in cortical gray matter across subjects were 140.4 ± 14.9, 134.1 ± 12.5, and 184.6 ± 17.9 μmol/100 g/min, with corresponding OEFs of 30.9 ± 3.4%, 30.0 ± 1.8%, and 40.9 ± 2.4% for methods based on QSM, qBOLD, and QSM+qBOLD, respectively. QSM+qBOLD provided the highest CMRO 2 contrast between gray and white matter, more uniform OEF than QSM, and less noisy OEF than qBOLD. Quantitative CMRO 2 mapping that fits the entire complex GRE data is feasible by combining QSM analysis of phase and qBOLD analysis of magnitude. © 2018 International Society for Magnetic Resonance in Medicine.

  13. Real-time fMRI neurofeedback of the mediodorsal and anterior thalamus enhances correlation between thalamic BOLD activity and alpha EEG rhythm.

    Science.gov (United States)

    Zotev, Vadim; Misaki, Masaya; Phillips, Raquel; Wong, Chung Ki; Bodurka, Jerzy

    2018-02-01

    Real-time fMRI neurofeedback (rtfMRI-nf) with simultaneous EEG allows volitional modulation of BOLD activity of target brain regions and investigation of related electrophysiological activity. We applied this approach to study correlations between thalamic BOLD activity and alpha EEG rhythm. Healthy volunteers in the experimental group (EG, n = 15) learned to upregulate BOLD activity of the target region consisting of the mediodorsal (MD) and anterior (AN) thalamic nuclei using rtfMRI-nf during retrieval of happy autobiographical memories. Healthy subjects in the control group (CG, n = 14) were provided with a sham feedback. The EG participants were able to significantly increase BOLD activities of the MD and AN. Functional connectivity between the MD and the inferior precuneus was significantly enhanced during the rtfMRI-nf task. Average individual changes in the occipital alpha EEG power significantly correlated with the average MD BOLD activity levels for the EG. Temporal correlations between the occipital alpha EEG power and BOLD activities of the MD and AN were significantly enhanced, during the rtfMRI-nf task, for the EG compared to the CG. Temporal correlations with the alpha power were also significantly enhanced for the posterior nodes of the default mode network, including the precuneus/posterior cingulate, and for the dorsal striatum. Our findings suggest that the temporal correlation between the MD BOLD activity and posterior alpha EEG power is modulated by the interaction between the MD and the inferior precuneus, reflected in their functional connectivity. Our results demonstrate the potential of the rtfMRI-nf with simultaneous EEG for noninvasive neuromodulation studies of human brain function. © 2017 Wiley Periodicals, Inc.

  14. Scattering amplitudes in four- and six-dimensional gauge theories

    International Nuclear Information System (INIS)

    Schuster, Theodor

    2014-01-01

    We study scattering amplitudes in quantum chromodynamics (QCD), N=4 super Yang-Mills (SYM) theory and the six-dimensional N=(1,1) SYM theory, focusing on the symmetries of and relations between the tree-level scattering amplitudes in these three gauge theories. We derive the tree level and one-loop color decomposition of an arbitrary QCD amplitude into primitive amplitudes. Furthermore, we derive identities spanning the null space among the primitive amplitudes. We prove that every color ordered tree amplitude of massless QCD can be obtained from gluon-gluino amplitudes of N=4 SYM theory. Furthermore, we derive analytical formulae for all gluon-gluino amplitudes relevant for QCD. We compare the numerical efficiency and accuracy of evaluating these closed analytic formulae for color ordered QCD tree amplitudes to a numerically efficient implementation of the Berends-Giele recursion. We derive the symmetries of massive tree amplitudes on the coulomb branch of N=4 SYM theory, which in turn can be obtained from N=(1,1) SYM theory by dimensional reduction. Furthermore, we investigate the tree amplitudes of N=(1, 1) SYM theory and explain how analytical formulae can be obtained from a numerical implementation of the supersymmetric BCFW recursion relation and investigate a potential uplift of the massless tree amplitudes of N=4 SYM theory. Finally we study an alternative to dimensional regularization of N=4 SYM theory. The infrared divergences are regulated by masses obtained from a Higgs mechanism. The corresponding string theory set-up suggests that the amplitudes have an exact dual conformal symmetry. We confirm this expectation and illustrate the calculational advantages of the massive regulator by explicit calculations.

  15. Cerebrospinal fluid pulsation amplitude and its quantitative relationship to cerebral blood flow pulsations: a phase-contrast MR flow imaging study

    International Nuclear Information System (INIS)

    Bhadelia, R.A.; Bogdan, A.R.; Kaplan, R.F.; Wolpert, S.M.

    1997-01-01

    Our purpose in this investigation was to explain the heterogeneity in the cerebrospinal fluid (CSF) flow pulsation amplitudes. To this end, we determined the contributions of the cerebral arterial and jugular venous flow pulsations to the amplitude of the CSF pulsation. We examined 21 healthy subjects by cine phase-contrast MRI at the C2-3 disc level to demonstrate the CSF and vascular flows as waveforms. Multiple regression analysis was performed to calculate the contributions of (a) the arterial and venous waveform amplitudes and (b) the delay between the maximum systolic slopes of the arterial and venous waveforms (AV delay), in order to predict the amplitude of the CSF waveform. The contribution of the arterial waveform amplitude was positive (r = 0.61; p 0.003) to the CSF waveform amplitude and that of the venous waveform amplitude was negative (r = -0.50; p = 0.006). Both in combination accounted for 56 % of the variance in predicting the CSF waveform amplitude (p < 0.0006). The contribution of AV delay was not significant. The results show that the variance in the CSF flow pulsation amplitudes can be explained by concurrent evaluation of the CSF and vascular flows. Improvement in the techniques, and controlled experiments, may allow use of CSF flow pulsation amplitudes for clinical applications in the non-invasive assessment of intracranial dynamics by MRI. (orig.). With 3 figs., 2 tabs

  16. Amplitude growth due to random, correlated kicks

    International Nuclear Information System (INIS)

    Michelotti, L.; Mills, F.

    1989-03-01

    Historically, stochastic processes, such as gas scattering or stochastic cooling, have been treated by the Fokker-Planck equation. In this approach, usually considered for one dimension only, the equation can be considered as a continuity equation for a variable which would be a constant of the motion in the absence of the stochastic process, for example, the action variable, I = ε/2π for betatron oscillations, where ε is the area of the Courant-Snyder ellipse, or energy in the case of unbunched beams, or the action variable for phase oscillations in case the beam is bunched. A flux, /Phi/, including diffusive terms can be defined, usually to second order. /Phi/ = M 1 F(I) + M 2 ∂F/∂I + /hor ellipsis/. M 1 and M 2 are the expectation values of δI and (δI) 2 due to the individual stochastic kicks over some period of time, long enough that the variance of these quantities is sufficiently small. Then the Fokker-Planck equation is just ∂F/∂I + ∂/Phi//∂I = 0. In many cases those where the beam distribution has already achieved its final shape, it is sufficient to find the rate of increase of by taking simple averages over the Fokker-Planck equation. At the time this work was begun, there was good knowledge of the second moment for general stochastic processes due to stochastic cooling theory, but the form of the first moment was known only for extremely wideband processes. The purposes of this note are to derive an expression relating the expected single particle amplitude growth to the noise autocorrelation function and to obtain, thereby, the form of M 1 for narrow band processes. 4 refs

  17. Frequency-Specific Alternations in the Amplitude of Low-Frequency Fluctuations in Chronic Tinnitus

    Directory of Open Access Journals (Sweden)

    Yu-Chen eChen

    2015-10-01

    Full Text Available Tinnitus, a phantom ringing, buzzing or hissing sensation with potentially debilitating consequences, is thought to arise from aberrant spontaneous neural activity at one or more sites within the central nervous system; however, the location and specific features of these oscillations are poorly understood with respect to specific tinnitus features. Recent resting-state functional magnetic resonance imaging (fMRI studies suggest that aberrant fluctuations in spontaneous low-frequency oscillations (LFO of the blood oxygen level-dependent (BOLD signal may be an important factor in chronic tinnitus; however, the role that frequency-specific components of LFO play in subjective tinnitus remains unclear. A total of 39 chronic tinnitus patients and 41 well-matched healthy controls participated in the resting-state fMRI scans. The LFO amplitudes were investigated using the amplitude of low-frequency fluctuation (ALFF and fractional ALFF (fALFF in two different frequency bands (slow-4: 0.027-0.073 Hz and slow-5: 0.01-0.027 Hz. We observed significant differences between tinnitus patients and normal controls in ALFF/fALFF in the two bands (slow-4 and slow-5 in several brain regions including the superior frontal gyrus (SFG, inferior frontal gyrus, middle temporal gyrus, angular gyrus, supramarginal gyrus, and middle occipital gyrus. Across the entire subject pool, significant differences in ALFF/fALFF between the two bands were found in the midbrain, basal ganglia, hippocampus and cerebellum (Slow 4>Slow 5, and in the middle frontal gyrus, supramarginal gyrus, posterior cingulate cortex, and precuneus (Slow 5>Slow 4. We also observed significant interaction between frequency bands and patient groups in the orbitofrontal gyrus. Furthermore, tinnitus distress was positively correlated with the magnitude of ALFF in right SFG and the magnitude of fALFF slow-4 band in left SFG, whereas tinnitus duration was positively correlated with the magnitude of ALFF in

  18. Relative amplitude preservation processing utilizing surface consistent amplitude correction. Part 4; Surface consistent amplitude correction wo mochiita sotai shinpuku hozon shori. 4

    Energy Technology Data Exchange (ETDEWEB)

    Saeki, T [Japan National Oil Corp., Tokyo (Japan). Technology Research Center

    1997-10-22

    Discussions were given on seismic exploration from the ground surface using the reflection method, for surface consistent amplitude correction from among effects imposed from the ground surface and a surface layer. Amplitude distribution on the reflection wave zone is complex. Therefore, items to be considered in making an analysis are multiple, such as estimation of spherical surface divergence effect and exponential attenuation effect, not only amplitude change through the surface layer. If all of these items are taken into consideration, burden of the work becomes excessive. As a method to solve this problem, utilization of amplitude in initial movement of a diffraction wave may be conceived. Distribution of the amplitude in initial movement of the diffraction wave shows a value relatively close to distribution of the vibration transmitting and receiving points. The reason for this is thought because characteristics of the vibration transmitting and receiving points related with waveline paths in the vicinity of the ground surface have no great difference both on the diffraction waves and on the reflection waves. The lecture described in this paper introduces an attempt of improving the efficiency of the surface consistent amplitude correction by utilizing the analysis of amplitude in initial movement of the diffraction wave. 4 refs., 2 figs.

  19. Receiver function estimated by maximum entropy deconvolution

    Institute of Scientific and Technical Information of China (English)

    吴庆举; 田小波; 张乃铃; 李卫平; 曾融生

    2003-01-01

    Maximum entropy deconvolution is presented to estimate receiver function, with the maximum entropy as the rule to determine auto-correlation and cross-correlation functions. The Toeplitz equation and Levinson algorithm are used to calculate the iterative formula of error-predicting filter, and receiver function is then estimated. During extrapolation, reflective coefficient is always less than 1, which keeps maximum entropy deconvolution stable. The maximum entropy of the data outside window increases the resolution of receiver function. Both synthetic and real seismograms show that maximum entropy deconvolution is an effective method to measure receiver function in time-domain.

  20. Contributions of contour frequency, amplitude, and luminance to the watercolor effect estimated by conjoint measurement.

    Science.gov (United States)

    Gerardin, Peggy; Devinck, Frédéric; Dojat, Michel; Knoblauch, Kenneth

    2014-04-10

    The watercolor effect is a long-range, assimilative, filling-in phenomenon induced by a pair of distant, wavy contours of different chromaticities. Here, we measured joint influences of the contour frequency and amplitude and the luminance of the interior contour on the strength of the effect. Contour pairs, each enclosing a circular region, were presented with two of the dimensions varying independently across trials (luminance/frequency, luminance/amplitude, frequency/amplitude) in a conjoint measurement paradigm (Luce & Tukey, 1964). In each trial, observers judged which of the stimuli evoked the strongest fill-in color. Control stimuli were identical except that the contours were intertwined and generated little filling-in. Perceptual scales were estimated by a maximum likelihood method (Ho, Landy, & Maloney, 2008). An additive model accounted for the joint contributions of any pair of dimensions. As shown previously using difference scaling (Devinck & Knoblauch, 2012), the strength increases with luminance of the interior contour. The strength of the phenomenon was nearly independent of the amplitude of modulation of the contour but increased with its frequency up to an asymptotic level. On average, the strength of the effect was similar along a given dimension regardless of the other dimension with which it was paired, demonstrating consistency of the underlying estimated perceptual scales.

  1. Effect of initial perturbation amplitude on Richtmyer-Meshkov flows induced by strong shocks

    Energy Technology Data Exchange (ETDEWEB)

    Dell, Z.; Abarzhi, S. I., E-mail: snezhana.abarzhi@gmail.com, E-mail: sabarji@andrew.cmu.edu [Mellon College of Science and Carnegie Mellon University – Qatar, Carnegie Mellon University, Pittsburgh, Pennsylvania 15231 (United States); Stellingwerf, R. F. [Stellingwerf Consulting, Huntsville, Alabama 35803 (United States)

    2015-09-15

    We systematically study the effect of the initial perturbation on Richtmyer-Meshkov (RM) flows induced by strong shocks in fluids with contrasting densities. Smooth Particle Hydrodynamics simulations are employed. A broad range of shock strengths and density ratios is considered. The amplitude of the initial single mode sinusoidal perturbation of the interface varies from 0% to 100% of its wavelength. The simulations results are compared, wherever possible, with four rigorous theories, and with other experiments and simulations, achieving good quantitative and qualitative agreement. Our study is focused on early time dynamics of the Richtmyer-Meshkov instability (RMI). We analyze the initial growth-rate of RMI immediately after the shock passage, when the perturbation amplitude increases linearly with time. For the first time, to the authors' knowledge, we find that the initial growth-rate of RMI is a non-monotone function of the initial perturbation amplitude, thus restraining the amount of energy that can be deposited by the shock at the interface. The maximum value of the initial growth-rate depends on the shock strength and the density ratio, whereas the corresponding value of the initial perturbation amplitude depends only slightly on the shock strength and density ratio.

  2. Available pressure amplitude of linear compressor based on phasor triangle model

    Science.gov (United States)

    Duan, C. X.; Jiang, X.; Zhi, X. Q.; You, X. K.; Qiu, L. M.

    2017-12-01

    The linear compressor for cryocoolers possess the advantages of long-life operation, high efficiency, low vibration and compact structure. It is significant to study the match mechanisms between the compressor and the cold finger, which determines the working efficiency of the cryocooler. However, the output characteristics of linear compressor are complicated since it is affected by many interacting parameters. The existing matching methods are simplified and mainly focus on the compressor efficiency and output acoustic power, while neglecting the important output parameter of pressure amplitude. In this study, a phasor triangle model basing on analyzing the forces of the piston is proposed. It can be used to predict not only the output acoustic power, the efficiency, but also the pressure amplitude of the linear compressor. Calculated results agree well with the measurement results of the experiment. By this phasor triangle model, the theoretical maximum output pressure amplitude of the linear compressor can be calculated simply based on a known charging pressure and operating frequency. Compared with the mechanical and electrical model of the linear compressor, the new model can provide an intuitionistic understanding on the match mechanism with faster computational process. The model can also explain the experimental phenomenon of the proportional relationship between the output pressure amplitude and the piston displacement in experiments. By further model analysis, such phenomenon is confirmed as an expression of the unmatched design of the compressor. The phasor triangle model may provide an alternative method for the compressor design and matching with the cold finger.

  3. Analyticity properties of two-body helicity amplitudes; Proprietes d'analyticite des amplitudes d'helicite a deux corps

    Energy Technology Data Exchange (ETDEWEB)

    Navelet-Noualhier, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-06-15

    Helicity amplitudes are expressed via the spinor amplitudes in terms of the Joos invariant which have been shown by Williams to be free from kinematical singularities. This procedure allows to analyze the kinematical singularities of helicity amplitudes and separate them out, which results into the definition of regularized helicity amplitudes. A crossing matrix for helicity amplitudes, is written down, corresponding to the continuation path used to cross spinor amplitudes. We verify explicitly that the corresponding crossing matrix for regularized helicity amplitudes is uniform as it should be. Kinematical constraints which generalize, to the case of arbitrary spins and masses, relations which must hold between helicity amplitudes at some values of the energy variable in {pi}N {yields} {pi}N, {pi}{pi} {yields} NN-bar and NN-bar {yields} NN-bar reactions, appear as a consequence of the existence of poles in the crossing matrix between regularized helicity amplitudes. An english version of this work has been written with G. Cohen-Tannoudji and A. Morel and submitted for publication to Annals of Physics. (author) [French] Les amplitudes d'helicite pour une reaction a deux corps sont exprimees, par l'intermediaire des amplitudes spinorielles, en fonction d'amplitudes invariantes de Joos qui sont, comme l'a montre Williams, sans singularites cinematiques. Ce procede nous permet d'analyser puis d'eliminer les singularites cinematiques des amplitudes d'helicite. Ceci nous conduit a la definition d'amplitudes d'helicite 'regularisees'. Une relation de 'croisement' entre amplitudes d'helicite est ecrite; elle realise leur prolongement analytique le long du chemin utilise pour 'croiser' les amplitudes spinorielles. Nous verifions que les elements de la matrice de croisement entre amplitudes d'helicite 'regularisees' sont bien uniformes. Les contraintes cinematiques qui generalisent, au cas de masses et de spins arbitraires, les relations obtenues dans les reactions {pi

  4. Eikonal representation of N-body Coulomb scattering amplitudes

    International Nuclear Information System (INIS)

    Fried, H.M.; Kang, K.; McKellar, B.H.J.

    1983-01-01

    A new technique for the construction of N-body Coulomb scattering amplitudes is proposed, suggested by the simplest case of N = 2: Calculate the scattering amplitude in eikonal approximation, discard the infinite phase factors which appear upon taking the limit of a Coulomb potential, and treat the remainder as an amplitude whose absolute value squared produces the exact, Coulomb differential cross section. The method easily generalizes to the N-body Coulomb problem for elastic scattering, and for inelastic rearrangement scattering of Coulomb bound states. We give explicit results for N = 3 and 4; in the N = 3 case we extract amplitudes for the processes (12)+3->1+2+3 (breakup), (12)+3->1+(23) (rearrangement), and (12)+3→(12)'+3 (inelastic scattering) as residues at the appropriate poles in the free-free amplitude. The method produces scattering amplitudes f/sub N/ given in terms of explicit quadratures over (N-2) 2 distinct integrands

  5. Expansion of all multitrace tree level EYM amplitudes

    Science.gov (United States)

    Du, Yi-Jian; Feng, Bo; Teng, Fei

    2017-12-01

    In this paper, we investigate the expansion of tree level multitrace Einstein-Yang-Mills (EYM) amplitudes. First, we propose two types of recursive expansions of tree level EYM amplitudes with an arbitrary number of gluons, gravitons and traces by those amplitudes with fewer traces or/and gravitons. Then we give many support evidence, including proofs using the Cachazo-He-Yuan (CHY) formula and Britto-Cachazo-Feng-Witten (BCFW) recursive relation. As a byproduct, two types of generalized BCJ relations for multitrace EYM are further proposed, which will be useful in the BCFW proof. After one applies the recursive expansions repeatedly, any multitrace EYM amplitudes can be given in the Kleiss-Kuijf (KK) basis of tree level color ordered Yang-Mills (YM) amplitudes. Thus the Bern-Carrasco-Johansson (BCJ) numerators, as the expansion coefficients, for all multitrace EYM amplitudes are naturally constructed.

  6. Maximum Power from a Solar Panel

    Directory of Open Access Journals (Sweden)

    Michael Miller

    2010-01-01

    Full Text Available Solar energy has become a promising alternative to conventional fossil fuel sources. Solar panels are used to collect solar radiation and convert it into electricity. One of the techniques used to maximize the effectiveness of this energy alternative is to maximize the power output of the solar collector. In this project the maximum power is calculated by determining the voltage and the current of maximum power. These quantities are determined by finding the maximum value for the equation for power using differentiation. After the maximum values are found for each time of day, each individual quantity, voltage of maximum power, current of maximum power, and maximum power is plotted as a function of the time of day.

  7. Tensor exchange amplitudes in K +- N charge exchange reactions

    International Nuclear Information System (INIS)

    Svec, M.

    1979-01-01

    Tensor (A 2 ) exchange amplitudes in K +- N charge exchange (CEX) are constructed from the K +- N CEX data supplemented by information on the vector (rho) exchange amplitudes from πN sca tering. We observed new features in the t-structure of A 2 exchange amplitudes which contradict the t-de pendence anticipated by most of the Regge models. The results also provide evidence for violation of weak exchange degeneracy

  8. Loop Amplitudes in Pure Yang-Mills from Generalised Unitarity

    OpenAIRE

    Brandhuber, Andreas; McNamara, Simon; Spence, Bill; Travaglini, Gabriele

    2005-01-01

    We show how generalised unitarity cuts in D = 4 - 2 epsilon dimensions can be used to calculate efficiently complete one-loop scattering amplitudes in non-supersymmetric Yang-Mills theory. This approach naturally generates the rational terms in the amplitudes, as well as the cut-constructible parts. We test the validity of our method by re-deriving the one-loop ++++, -+++, --++, -+-+ and +++++ gluon scattering amplitudes using generalised quadruple cuts and triple cuts in D dimensions.

  9. Loop amplitudes in pure Yang-Mills from generalised unitarity

    International Nuclear Information System (INIS)

    Brandhuber, Andreas; McNamara, Simon; Spence, Bill; Travaglini, Gabriele

    2005-01-01

    We show how generalised unitarity cuts in D = 4-2ε dimensions can be used to calculate efficiently complete one-loop scattering amplitudes in non-supersymmetric Yang-Mills theory. This approach naturally generates the rational terms in the amplitudes, as well as the cut-constructible parts. We test the validity of our method by re-deriving the one-loop ++++, -+++, --++, -+-+ and +++++ gluon scattering amplitudes using generalised quadruple cuts and triple cuts in D dimensions

  10. Loop amplitudes in pure Yang-Mills from generalised unitarity

    Energy Technology Data Exchange (ETDEWEB)

    Brandhuber, Andreas [Department of Physics, Queen Mary, University of London, Mile End Road, London, E1 4NS (United Kingdom); McNamara, Simon [Department of Physics, Queen Mary, University of London, Mile End Road, London, E1 4NS (United Kingdom); Spence, Bill [Department of Physics, Queen Mary, University of London, Mile End Road, London, E1 4NS (United Kingdom); Travaglini, Gabriele [Department of Physics, Queen Mary, University of London, Mile End Road, London, E1 4NS (United Kingdom)

    2005-10-15

    We show how generalised unitarity cuts in D = 4-2{epsilon} dimensions can be used to calculate efficiently complete one-loop scattering amplitudes in non-supersymmetric Yang-Mills theory. This approach naturally generates the rational terms in the amplitudes, as well as the cut-constructible parts. We test the validity of our method by re-deriving the one-loop ++++, -+++, --++, -+-+ and +++++ gluon scattering amplitudes using generalised quadruple cuts and triple cuts in D dimensions.

  11. Calculation and modular properties of multiloop superstring amplitudes

    International Nuclear Information System (INIS)

    Danilov, G. S.

    2013-01-01

    Multiloop superstring amplitudes are calculated within an extensively used gauge where the two-dimensional gravitino field carries Grassmann moduli. In general, the amplitudes possess, instead of modular symmetry, symmetry with respect to modular transformation supplemented with appropriate transformations of two-dimensional local supersymmetry. If the number of loops is larger than three, the integrationmeasures are notmodular forms, while the expression for the amplitude contains integrals along the boundary of the fundamental region of the modular group.

  12. Efficient analytic computation of higher-order QCD amplitudes

    International Nuclear Information System (INIS)

    Bern, Z.; Chalmers, G.; Dunbar, D.C.; Kosower, D.A.

    1995-01-01

    The authors review techniques simplifying the analytic calculation of one-loop QCD amplitudes with many external legs, for use in next-to-leading-order corrections to multi-jet processes. Particularly useful are the constraints imposed by perturbative unitarity, collinear singularities and a supersymmetry-inspired organization of helicity amplitudes. Certain sequences of one-loop helicity amplitudes with an arbitrary number of external gluons have been obtained using these constraints

  13. Improved pion pion scattering amplitude from dispersion relation formalism

    International Nuclear Information System (INIS)

    Cavalcante, I.P.; Coutinho, Y.A.; Borges, J. Sa

    2005-01-01

    Pion-pion scattering amplitude is obtained from Chiral Perturbation Theory at one- and two-loop approximations. Dispersion relation formalism provides a more economic method, which was proved to reproduce the analytical structure of that amplitude at both approximation levels. This work extends the use of the formalism in order to compute further unitarity corrections to partial waves, including the D-wave amplitude. (author)

  14. Ambitwistor strings and reggeon amplitudes in N=4 SYM

    Directory of Open Access Journals (Sweden)

    L.V. Bork

    2017-11-01

    Full Text Available We consider the description of reggeon amplitudes (Wilson lines form factors in N=4 SYM within the framework of four dimensional ambitwistor string theory. The latter is used to derive scattering equations representation for reggeon amplitudes with multiple reggeized gluons present. It is shown, that corresponding tree-level string correlation function correctly reproduces previously obtained Grassmannian integral representation of reggeon amplitudes in N=4 SYM.

  15. The five-gluon amplitude and one-loop integrals

    International Nuclear Information System (INIS)

    Bern, Z.; Dixon, L.; Kosower, D.A.

    1992-12-01

    We review the conventional field theory description of the string motivated technique. This technique is applied to the one-loop five-gluon amplitude. To evaluate the amplitude a general method for computing dimensionally regulated one-loop integrals is outlined including results for one-loop integrals required for the pentagon diagram and beyond. Finally, two five-gluon helicity amplitudes are given

  16. Renormalization in the complete Mellin representation of Feynman amplitudes

    International Nuclear Information System (INIS)

    Calan, C. de; David, F.; Rivasseau, V.

    1981-01-01

    The Feynmann amplitudes are renormalized in the formalism of the CM representation. This Mellin-Barnes type integral representation, previously introduced for the study of asymptotic behaviours, is shown to have the following interesting property: in contrast with the usual subtraction procedures, the renormalization leaves the CM intergrand unchanged, and only results into translations of the integration path. The explicit CM representation of the renormalized amplitudes is given. In addition, the dimensional regularization and the extension to spinor amplitudes are sketched. (orig.)

  17. Interleaved quantitative BOLD: Combining extravascular R2' - and intravascular R2-measurements for estimation of deoxygenated blood volume and hemoglobin oxygen saturation.

    Science.gov (United States)

    Lee, Hyunyeol; Englund, Erin K; Wehrli, Felix W

    2018-03-23

    Quantitative BOLD (qBOLD), a non-invasive MRI method for assessment of hemodynamic and metabolic properties of the brain in the baseline state, provides spatial maps of deoxygenated blood volume fraction (DBV) and hemoglobin oxygen saturation (HbO 2 ) by means of an analytical model for the temporal evolution of free-induction-decay signals in the extravascular compartment. However, mutual coupling between DBV and HbO 2 in the signal model results in considerable estimation uncertainty precluding achievement of a unique set of solutions. To address this problem, we developed an interleaved qBOLD method (iqBOLD) that combines extravascular R 2 ' and intravascular R 2 mapping techniques so as to obtain prior knowledge for the two unknown parameters. To achieve these goals, asymmetric spin echo and velocity-selective spin-labeling (VSSL) modules were interleaved in a single pulse sequence. Prior to VSSL, arterial blood and CSF signals were suppressed to produce reliable estimates for cerebral venous blood volume fraction (CBV v ) as well as venous blood R 2 (to yield HbO 2 ). Parameter maps derived from the VSSL module were employed to initialize DBV and HbO 2 in the qBOLD processing. Numerical simulations and in vivo experiments at 3 T were performed to evaluate the performance of iqBOLD in comparison to the parent qBOLD method. Data obtained in eight healthy subjects yielded plausible values averaging 60.1 ± 3.3% for HbO 2 and 3.1 ± 0.5 and 2.0 ± 0.4% for DBV in gray and white matter, respectively. Furthermore, the results show that prior estimates of CBV v and HbO 2 from the VSSL component enhance the solution stability in the qBOLD processing, and thus suggest the feasibility of iqBOLD as a promising alternative to the conventional technique for quantifying neurometabolic parameters. Copyright © 2018. Published by Elsevier Inc.

  18. The spectrum of R Cygni during its exceptionally low maximum of 1983

    International Nuclear Information System (INIS)

    Wallerstein, G.; Dominy, J.F.; Mattei, J.A.; Smith, V.V.

    1985-01-01

    In 1983 R Cygni experienced its faintest maximum ever recorded. A study of the light curve shows correlations between brightness at maximum and interval from the previous cycle, in the sense that fainter maxima occur later than normal and are followed by maxima that occur earlier than normal. Emission and absorption lines in the optical and near infrared (2.2 μm region) reveal two significant correlations. The amplitude of line doubling is independent of the magnitude at maximum for msub(v)(max)=7.1 to 9.8. The velocities of the emission lines, however, correlate with the magnitude at maximum, in that during bright maxima they are negatively displaced by 15 km s -1 with respect to the red component of absorption lines, while during the faintest maximum there is no displacement. (author)

  19. Algebraic evaluation of rational polynomials in one-loop amplitudes

    International Nuclear Information System (INIS)

    Binoth, Thomas; Guillet, Jean-Philippe; Heinrich, Gudrun

    2007-01-01

    One-loop amplitudes are to a large extent determined by their unitarity cuts in four dimensions. We show that the remaining rational terms can be obtained from the ultraviolet behaviour of the amplitude, and determine universal form factors for these rational parts by applying reduction techniques to the Feynman diagrammatic representation of the amplitude. The method is valid for massless and massive internal particles. We illustrate this method by evaluating the rational terms of the one-loop amplitudes for gg→H, γγ→γγ, gg→gg,γγ→ggg and γγ→γγγγ

  20. Phase and amplitude control system for Stanford Linear Accelerator

    International Nuclear Information System (INIS)

    Yoo, S.J.

    1983-01-01

    The computer controlled phase and amplitude detection system measures the instantaneous phase and amplitude of a 1 micro-second 2856 MHz rf pulse at a 180 Hz rate. This will be used for phase feedback control, and also for phase and amplitude jitter measurement. The program, which was originally written by John Fox and Keith Jobe, has been modified to improve the function of the system. The software algorithms used in the measurement are described, as is the performance of the prototype phase and amplitude detector system

  1. New rigorous asymptotic theorems for inverse scattering amplitudes

    International Nuclear Information System (INIS)

    Lomsadze, Sh.Yu.; Lomsadze, Yu.M.

    1984-01-01

    The rigorous asymptotic theorems both of integral and local types obtained earlier and establishing logarithmic and in some cases even power correlations aetdeen the real and imaginary parts of scattering amplitudes Fsub(+-) are extended to the inverse amplitudes 1/Fsub(+-). One also succeeds in establishing power correlations of a new type between the real and imaginary parts, both for the amplitudes themselves and for the inverse ones. All the obtained assertions are convenient to be tested in high energy experiments when the amplitudes show asymptotic behaviour

  2. Proof of the fundamental BCJ relations for QCD amplitudes

    International Nuclear Information System (INIS)

    Cruz, Leonardo de la; Kniss, Alexander; Weinzierl, Stefan

    2015-01-01

    The fundamental BCJ-relation is a linear relation between primitive tree amplitudes with different cyclic orderings. The cyclic orderings differ by the insertion place of one gluon. The coefficients of the fundamental BCJ-relation are linear in the Lorentz invariants 2p_ip_j. The BCJ-relations are well established for pure gluonic amplitudes as well as for amplitudes in N=4 super-Yang-Mills theory. Recently, it has been conjectured that the BCJ-relations hold also for QCD amplitudes. In this paper we give a proof of this conjecture. The proof is valid for massless and massive quarks.

  3. Amplitude dependent damping in single crystalline high purity molybdenum

    International Nuclear Information System (INIS)

    Zelada-Lambri, G.I; Lambri, O.A; Garcia, J.A; Lomer, J.N

    2004-01-01

    Amplitude dependent damping measurements were performed on high purity single crystalline molybdenum at several different constant temperatures between room temperature and 1273K. The employed samples were single crystals with the orientation, having a residual resistivity ratio of about 8000. Previously to the amplitude dependent damping tests, the samples were subjected to different thermomechanical histories. Amplitude dependent damping effects appear only during the first heating run in temperature where the samples have the thermomechanical state of the deformation process at room temperature. In the subsequent run-ups in temperature, i.e, after subsequent annealings, amplitude dependent damping effects were not detected (au)

  4. Analytical structure of the 3. -->. 3 forward scattering amplitude

    Energy Technology Data Exchange (ETDEWEB)

    Logunov, A A; Medvedev, B V; Muzafarov, L M; Pavlov, V P; Polivanov, M K; Sukhanov, A D [AN SSSR, Moscow. Matematicheskij Inst.

    1979-08-01

    Analytical properties of the amplitude of 3..-->..3 forward scattering established in the framework of the Bogolyubov axiomatic approach are described. The amplitudes of the different channels of the process are boundary values of a unique analytical function of invariant variables. Crossing-symmetry property of the amplitude is proved. Analysis of the absorptive part of the amplitude is performed and the generalized optical theorem is proved which connects one of the contributions into the absorptive part with the distribution function of the inclusive process.

  5. Generalized unitarity for N=4 super-amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Drummond, J.M.; Henn, J. [LAPTH, Université de Savoie, CNRS B.P. 110, F-74941 Annecy-le-Vieux Cedex (France); Korchemsky, G.P., E-mail: Gregory.Korchemsky@cea.fr [Institut de Physique Théorique, CEA Saclay, 91191 Gif-sur-Yvette Cedex (France); Sokatchev, E. [LAPTH, Université de Savoie, CNRS B.P. 110, F-74941 Annecy-le-Vieux Cedex (France)

    2013-04-21

    We develop a manifestly supersymmetric version of the generalized unitarity cut method for calculating scattering amplitudes in N=4 SYM theory. We illustrate the power of this method by computing the one-loop n-point NMHV super-amplitudes. The result confirms two conjectures which we made in Drummond, et al., [1]. Firstly, we derive the compact, manifestly dual superconformally covariant form of the NMHV tree amplitudes for arbitrary number and types of external particles. Secondly, we show that the ratio of the one-loop NMHV to the MHV amplitude is dual conformal invariant.

  6. Tree-level amplitudes and dual superconformal symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Drummond, J M, E-mail: drummond@lapp.in2p3.fr [PH-TH Division, CERN, CH-1211, Geneva 23 (Switzerland); LAPTH, Universite de Savoie, CNRS, B.P. 110, F-74941 Annecy-le-Vieux Cedex (France)

    2011-11-11

    We review the structure of gauge theory scattering amplitudes at tree level and describe how a compact expression can be found which encodes all the tree-level amplitudes in the maximally supersymmetric N=4 theory. The expressions for the amplitudes reveal a dual superconformal symmetry. We describe how these ideas can be extended to leading singularities and the loop integrand in the planar theory and discuss the appearance of dual conformal symmetry in higher-dimensional gauge theories. This paper is an invited review for a special issue of Journal of Physics A: Mathematical and Theoretical devoted to 'Scattering amplitudes in gauge theories'. (review)

  7. New relations for Einstein–Yang–Mills amplitudes

    International Nuclear Information System (INIS)

    Stieberger, Stephan; Taylor, Tomasz R.

    2016-01-01

    We obtain new relations between Einstein–Yang–Mills (EYM) amplitudes involving N gauge bosons plus a single graviton and pure Yang–Mills amplitudes involving N gauge bosons plus one additional vector boson inserted in a way typical for a gauge boson of a “spectator” group commuting with the group associated to original N gauge bosons. We show that such EYM amplitudes satisfy U(1) decoupling relations similar to Kleiss–Kuijf relations for Yang–Mills amplitudes. We consider a D-brane embedding of EYM amplitudes in the framework of disk amplitudes involving open and closed strings. A new set of monodromy relations is derived for mixed open–closed amplitudes with one closed string inserted on the disk world-sheet and a number of open strings at the boundary. These relations allow expressing the latter in terms of pure open string amplitudes and, in the field-theory limit, they yield the U(1) decoupling relations for EYM amplitudes.

  8. Accounting for the role of hematocrit in between-subject variations of MRI-derived baseline cerebral hemodynamic parameters and functional BOLD responses.

    Science.gov (United States)

    Xu, Feng; Li, Wenbo; Liu, Peiying; Hua, Jun; Strouse, John J; Pekar, James J; Lu, Hanzhang; van Zijl, Peter C M; Qin, Qin

    2018-01-01

    Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T 1 values by comparison with the conventional lab test. Together with CBF measured using phase-contrast MRI, this noninvasive estimation of Hct, instead of using a population-averaged Hct value, enabled more individual determination of oxygen delivery (DO 2 ), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO 2 ). The inverse correlation of CBF and Hct explained about 80% of between-subject variation of CBF in this relatively uniform cohort of subjects, as expected based on the regulation of DO 2 to maintain constant CMRO 2 . Furthermore, we compared the relationships of visual task-evoked BOLD response with Hct and CBF. We showed that Hct and CBF contributed 22%-33% of variance in BOLD signal and removing the positive correlation with Hct and negative correlation with CBF allowed normalization of BOLD signal with 16%-22% lower variability. The results of this study suggest that adjustment for Hct effects is useful for studies of MRI perfusion and BOLD fMRI. Hum Brain Mapp 39:344-353, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  9. SU-D-207A-03: Potential Role of BOLD MRI in Discrimination of Aggressive Tumor Habitat in Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ford, J; Lopez, C; Tschudi, Y; Breto, A; Padgett, K; Pollack, A; Stoyanova, R [University of Miami Miller School of Medicine, Miami, FL (United States)

    2016-06-15

    Purpose: To determine whether blood oxygenation level dependent (BOLD) MRI signal measured in prostate cancer patients, in addition to quantitative diffusion and perfusion parameters from multiparametric (mp)MRI exams, can help discriminate aggressive and/or radioresistant lesions. Methods: Several ongoing clinical trials in our institution require mpMRI exam to determine eligibility (presence of identifiable tumor lesion on mpMRI) and prostate volumes for dose escalation. Upon consent, patients undergo fiducial markers placement and a T2*-weighted imaging at the time of CT sim to facilitate the fusion. In a retrospective analysis eleven clinical trial patients were identified who had undergone mpMRI on GE 3T magnet, followed by T2*-weighted imaging (time-period mean±SD = 48±20 days) using a consistent protocol (gradient echo, TR/TE=30/11.8ms, flip angle=12, matrix=256×256×75, voxel size=1.25×1.25×2.5mm). ROIs for prostate tumor lesions were automatically determined using ADC threshold ≤1200 µm2/s. Although the MR protocol was not intended for BOLD analysis, we utilized the T2*-weighted signal normalized to that in nearby muscle; likewise, T2-weighted lesion signal was normalized to muscle, following rigid registration of the T2 to T2* images. The ratio of these normalized signals, T2*/T2, is a measure of BOLD effect in the prostate tumors. Perfusion parameters (Ktrans, ve, kep) were also calculated. Results: T2*/T2 (mean±SE) was found to be substantially lower for Gleason score (GS) 8&9 (0.82±0.04) compared to GS 7 (1.08±0.07). A k-means cluster analysis of T2*/T2 versus kep = Ktrans/ve revealed two distinct clusters, one with higher T2*/T2 and lower kep, containing only GS 7 lesions, and another with lower T2*/T2 and higher kep, associated with tumor aggressiveness. This latter cluster contained all GS 8&9 lesions, as well as some GS 7. Conclusion: BOLD MRI, in addition to ADC and kep, may play a role (perhaps orthogonal to Gleason score) in

  10. On the Five-Moment Hamburger Maximum Entropy Reconstruction

    Science.gov (United States)

    Summy, D. P.; Pullin, D. I.

    2018-05-01

    We consider the Maximum Entropy Reconstruction (MER) as a solution to the five-moment truncated Hamburger moment problem in one dimension. In the case of five monomial moment constraints, the probability density function (PDF) of the MER takes the form of the exponential of a quartic polynomial. This implies a possible bimodal structure in regions of moment space. An analytical model is developed for the MER PDF applicable near a known singular line in a centered, two-component, third- and fourth-order moment (μ _3 , μ _4 ) space, consistent with the general problem of five moments. The model consists of the superposition of a perturbed, centered Gaussian PDF and a small-amplitude packet of PDF-density, called the outlying moment packet (OMP), sitting far from the mean. Asymptotic solutions are obtained which predict the shape of the perturbed Gaussian and both the amplitude and position on the real line of the OMP. The asymptotic solutions show that the presence of the OMP gives rise to an MER solution that is singular along a line in (μ _3 , μ _4 ) space emanating from, but not including, the point representing a standard normal distribution, or thermodynamic equilibrium. We use this analysis of the OMP to develop a numerical regularization of the MER, creating a procedure we call the Hybrid MER (HMER). Compared with the MER, the HMER is a significant improvement in terms of robustness and efficiency while preserving accuracy in its prediction of other important distribution features, such as higher order moments.

  11. Maximum likelihood approach for several stochastic volatility models

    International Nuclear Information System (INIS)

    Camprodon, Jordi; Perelló, Josep

    2012-01-01

    Volatility measures the amplitude of price fluctuations. Despite it being one of the most important quantities in finance, volatility is not directly observable. Here we apply a maximum likelihood method which assumes that price and volatility follow a two-dimensional diffusion process where volatility is the stochastic diffusion coefficient of the log-price dynamics. We apply this method to the simplest versions of the expOU, the OU and the Heston stochastic volatility models and we study their performance in terms of the log-price probability, the volatility probability, and its Mean First-Passage Time. The approach has some predictive power on the future returns amplitude by only knowing the current volatility. The assumed models do not consider long-range volatility autocorrelation and the asymmetric return-volatility cross-correlation but the method still yields very naturally these two important stylized facts. We apply the method to different market indices and with a good performance in all cases. (paper)

  12. Boldness predicts an individual's position along an exploration-exploitation foraging trade-off.

    Science.gov (United States)

    Patrick, Samantha C; Pinaud, David; Weimerskirch, Henri

    2017-09-01

    -off itself. These results demonstrate a clear trade-off between information gathering and exploitation of prey patches, and reveals for the first time that boldness may drive these differences. This provides a mechanism through which widely reported links between personality and foraging may emerge. © 2017 The Authors. Journal of Animal Ecology published by John Wiley & Sons Ltd on behalf of British Ecological Society.

  13. The effect of solar and lunar currents on simultaneous phase path, group path and amplitude measurements

    International Nuclear Information System (INIS)

    Baulch, R.N.E.; Butcher, E.C.

    1984-01-01

    The solar and lunar variations in the phase path, group path and amplitude of a fixed frequency transmission were obtained at the September equinox over a slightly oblique path. The phase of the lunar semi-diurnal tide in the phase path and amplitude were similar, the maxima occurring near 0200 lunar time, whereas the group path had a maximum near 0800 lunar time. These results were compared with other results obtained near the same location. The results suggest a complex situation in the E-region, where the height of the lunar current depends on season, and also suggest that the location and distribution of the solar and lunar currents may be different. (author)

  14. Tip radius preservation for high resolution imaging in amplitude modulation atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Jorge R., E-mail: jorge.rr@cea.cu [Instituto de Ciencia de Materiales de Madrid, Sor Juana Inés de la Cruz 3, Canto Blanco, 28049 Madrid, España (Spain)

    2014-07-28

    The acquisition of high resolution images in atomic force microscopy (AFM) is correlated to the cantilever's tip shape, size, and imaging conditions. In this work, relative tip wear is quantified based on the evolution of a direct experimental observable in amplitude modulation atomic force microscopy, i.e., the critical amplitude. We further show that the scanning parameters required to guarantee a maximum compressive stress that is lower than the yield/fracture stress of the tip can be estimated via experimental observables. In both counts, the optimized parameters to acquire AFM images while preserving the tip are discussed. The results are validated experimentally by employing IgG antibodies as a model system.

  15. Source-Space Cross-Frequency Amplitude-Amplitude Coupling in Tinnitus

    Directory of Open Access Journals (Sweden)

    Oliver Zobay

    2015-01-01

    Full Text Available The thalamocortical dysrhythmia (TCD model has been influential in the development of theoretical explanations for the neurological mechanisms of tinnitus. It asserts that thalamocortical oscillations lock a region in the auditory cortex into an ectopic slow-wave theta rhythm (4–8 Hz. The cortical area surrounding this region is hypothesized to generate abnormal gamma (>30 Hz oscillations (“edge effect” giving rise to the tinnitus percept. Consequently, the model predicts enhanced cross-frequency coherence in a broad range between theta and gamma. In this magnetoencephalography study involving tinnitus and control cohorts, we investigated this prediction. Using beamforming, cross-frequency amplitude-amplitude coupling (AAC was computed within the auditory cortices for frequencies (f1,f2 between 2 and 80 Hz. We find the AAC signal to decompose into two distinct components at low (f1,f230 Hz frequencies, respectively. Studying the correlation of AAC with several key covariates (age, hearing level (HL, tinnitus handicap and duration, and HL at tinnitus frequency, we observe a statistically significant association between age and low-frequency AAC. Contrary to the TCD predictions, however, we do not find any indication of statistical differences in AAC between tinnitus and controls and thus no evidence for the predicted enhancement of cross-frequency coupling in tinnitus.

  16. True amplitude wave equation migration arising from true amplitude one-way wave equations

    Science.gov (United States)

    Zhang, Yu; Zhang, Guanquan; Bleistein, Norman

    2003-10-01

    One-way wave operators are powerful tools for use in forward modelling and inversion. Their implementation, however, involves introduction of the square root of an operator as a pseudo-differential operator. Furthermore, a simple factoring of the wave operator produces one-way wave equations that yield the same travel times as the full wave equation, but do not yield accurate amplitudes except for homogeneous media and for almost all points in heterogeneous media. Here, we present augmented one-way wave equations. We show that these equations yield solutions for which the leading order asymptotic amplitude as well as the travel time satisfy the same differential equations as the corresponding functions for the full wave equation. Exact representations of the square-root operator appearing in these differential equations are elusive, except in cases in which the heterogeneity of the medium is independent of the transverse spatial variables. Here, we address the fully heterogeneous case. Singling out depth as the preferred direction of propagation, we introduce a representation of the square-root operator as an integral in which a rational function of the transverse Laplacian appears in the integrand. This allows us to carry out explicit asymptotic analysis of the resulting one-way wave equations. To do this, we introduce an auxiliary function that satisfies a lower dimensional wave equation in transverse spatial variables only. We prove that ray theory for these one-way wave equations leads to one-way eikonal equations and the correct leading order transport equation for the full wave equation. We then introduce appropriate boundary conditions at z = 0 to generate waves at depth whose quotient leads to a reflector map and an estimate of the ray theoretical reflection coefficient on the reflector. Thus, these true amplitude one-way wave equations lead to a 'true amplitude wave equation migration' (WEM) method. In fact, we prove that applying the WEM imaging condition

  17. Amplitude-to-code converter for photomultipliers operating at high loadings

    International Nuclear Information System (INIS)

    Arkhangel'skij, B.V.; Evgrafov, G.N.; Pishchal'nikov, Yu.M.; Shuvalov, R.S.

    1982-01-01

    An 11-bit amplitude-to-code converter intended for the analysis of photomultiplier pulses under high loadings is described. To decrease the volume of digit electronics in the converter an analog memory on capacities is envisaged. A well-known bridge circuit with diodes on the main carriers is selected as a gating circuit. The gate control is realized by a switching circuit on fast-response transistors with boundary frequency of 1.2-1.5 GHz. The converter main characteristics are given, namely, maximum output signal amplitude equal to -1.5 V, minimum pulse selection duration of 10 ns, maximum number of counts at Usub(input)=-1.0 V and tsub(selection)=50 ns amounting to 1400, integral nonlinearity of +-0.1%, conversion temperature instability of 0.2%/deg C in the temperature range of (+10-+40) deg C, maximum time of data storage equal to 300 ms, conversion coefficient instability of 0.42 counts, number of channels in a unit CAMAC block equal to 12

  18. Increased low-frequency oscillation amplitude of sensorimotor cortex associated with the severity of structural impairment in cervical myelopathy.

    Directory of Open Access Journals (Sweden)

    Fuqing Zhou

    Full Text Available Decreases in metabolites and increased motor-related, but decreased sensory-related activation of the sensorimotor cortex (SMC have been observed in patients with cervical myelopathy (CM using advanced MRI techniques. However, the nature of intrinsic neuronal activity in the SMC, and the relationship between cerebral function and structural damage of the spinal cord in patients with CM are not fully understood. The purpose of this study was to assess intrinsic neuronal activity by calculating the regional amplitude of low frequency fluctuations (ALFF using resting-state functional MRI (rs-fMRI, and correlations with clinical and imaging indices. Nineteen patients and 19 age- and sex-matched healthy subjects underwent rs-fMRI scans. ALFF measurements were performed in the SMC, a key brain network likely to impaired or reorganized patients with CM. Compared with healthy subjects, increased amplitude of cortical low-frequency oscillations (LFO was observed in the right precentral gyrus, right postcentral gyrus, and left supplementary motor area. Furthermore, increased z-ALFF values in the right precentral gyrus and right postcentral gyrus correlated with decreased fractional anisotropy values at the C2 level, which indicated increased intrinsic neuronal activity in the SMC corresponding to the structural impairment in the spinal cord of patients with CM. These findings suggest a complex and diverging relationship of cortical functional reorganization and distal spinal anatomical compression in patients with CM and, thus, add important information in understanding how spinal cord integrity may be a factor in the intrinsic covariance of spontaneous low-frequency fluctuations of BOLD signals involved in cortical plasticity.

  19. Maximum permissible voltage of YBCO coated conductors

    Energy Technology Data Exchange (ETDEWEB)

    Wen, J.; Lin, B.; Sheng, J.; Xu, J.; Jin, Z. [Department of Electrical Engineering, Shanghai Jiao Tong University, Shanghai (China); Hong, Z., E-mail: zhiyong.hong@sjtu.edu.cn [Department of Electrical Engineering, Shanghai Jiao Tong University, Shanghai (China); Wang, D.; Zhou, H.; Shen, X.; Shen, C. [Qingpu Power Supply Company, State Grid Shanghai Municipal Electric Power Company, Shanghai (China)

    2014-06-15

    Highlights: • We examine three kinds of tapes’ maximum permissible voltage. • We examine the relationship between quenching duration and maximum permissible voltage. • Continuous I{sub c} degradations under repetitive quenching where tapes reaching maximum permissible voltage. • The relationship between maximum permissible voltage and resistance, temperature. - Abstract: Superconducting fault current limiter (SFCL) could reduce short circuit currents in electrical power system. One of the most important thing in developing SFCL is to find out the maximum permissible voltage of each limiting element. The maximum permissible voltage is defined as the maximum voltage per unit length at which the YBCO coated conductors (CC) do not suffer from critical current (I{sub c}) degradation or burnout. In this research, the time of quenching process is changed and voltage is raised until the I{sub c} degradation or burnout happens. YBCO coated conductors test in the experiment are from American superconductor (AMSC) and Shanghai Jiao Tong University (SJTU). Along with the quenching duration increasing, the maximum permissible voltage of CC decreases. When quenching duration is 100 ms, the maximum permissible of SJTU CC, 12 mm AMSC CC and 4 mm AMSC CC are 0.72 V/cm, 0.52 V/cm and 1.2 V/cm respectively. Based on the results of samples, the whole length of CCs used in the design of a SFCL can be determined.

  20. Effects of glyceryl trinitrate and calcitonin-gene-related peptide on BOLD signal and arterial diameter –methodological studies by fMRI and MRA

    DEFF Research Database (Denmark)

    Asghar, Mohammed Sohail; Ashina, Messoud

    2013-01-01

    Over the last decades MRI has proved to be very useful in the field of drug development and discovery. Pharmacological MRI (phMRI) explores the interaction between brain physiology, neuronal activity and drugs[1]. The BOLD-signal is an indirect method to investigate brain activity by way...... of measuring task-related hemodynamic changes. Pharmacological substances that induce hemodynamic changes can therefore potentially alter the BOLD-signal that in turn falsely can be interpreted as changes in neuronal activity. It is therefore important to characterize possible effects of a pharmacological...... substance on the BOLD-response per see before that substance can be used in an fMRI experiment. Furthermore MR-angiography is useful in determining the vascular site-of-action of vasoactive substances....