Danske 4. klasseelever er bedre end gennemsnittet til matematik og natur/teknologi
DEFF Research Database (Denmark)
Middelboe, Vibe Abildtrup
2016-01-01
En ny undersøgelse af 4. klasseelevers præstationer i fagene matematik og natur/teknologi viser, at danske elever klarer sig godt internationalt set, og at vi i Danmark har mange elever, der er meget dygtige til matematik. Men den negative sociale arv er fortsat stærk, og lærerne oplever mere stø...
DEFF Research Database (Denmark)
Ejersbo, Lisser Rye
2014-01-01
Hvad vil det sige at forstå matematik? Er det procedurerne, altså hvordan man gennemfører beregninger, der skal forstås, er det relationerne indenfor matematik, og hvordan man kan konkludere eller er det matematisk modellering, som starter i en virkelig kontekst, benytter matematik til at finde en...
PISA-undersøgelsen - kan den bruges til noget?
DEFF Research Database (Denmark)
Lindenskov, Lena; Jankvist, Uffe Thomas; Fink, Klaus
2014-01-01
Der gives beskrivelser af det indhold i PISA-rapporterne, som kan betyde noget for, hvordan matematiklærere og didaktikere kan handle. Med fokus på PISA 2012 gengives 4 matematik-spørgsmål, hovedresultater fra elevbesvarelser af opgaver og spørgeskemaer samt forklaringer og nye didaktiske spørgsm....... Der sammenlignes også kort med TIMSS 2011....
Obama skal ikke nyde noget af Syrien
DEFF Research Database (Denmark)
Ulrich, Philip Christian
2013-01-01
Mange har i lang tid undret sig over at konflikten i Syrien har kunnet få lov at stå på i så lang tid, uden at USA har vist lederskab og grebet ind. Det er jo den rolle vi er vant til at se USA i. Men Obama skal ikke nyde noget af at engagere sig i Syrien. Det har USA ikke råd til......Mange har i lang tid undret sig over at konflikten i Syrien har kunnet få lov at stå på i så lang tid, uden at USA har vist lederskab og grebet ind. Det er jo den rolle vi er vant til at se USA i. Men Obama skal ikke nyde noget af at engagere sig i Syrien. Det har USA ikke råd til...
Stor matematik mellem Prado og Escorial
DEFF Research Database (Denmark)
Booss-Bavnbek, Bernhelm
2006-01-01
Rapport over Den Internationale Matematikerkongres 2006: Hvad rangerer højst i 2006? Stokastik er kommet hjem. Forholdet mellem ren og anvendt matematik. Historie og didatik. Dansk synlighed - storhed eller begyndende senilitet? Udgivelsesdato: December 2006...
DEFF Research Database (Denmark)
Thomsen, Frej Klem
2014-01-01
Hvis man er skeptiker, så er moral nemlig altid kun et udtryk for psykologi og kultur, også når det handler om for eksempel misbrug af børn i Tønder-sagen eller terror-angreb i Madrid, London og Mumbai .......Hvis man er skeptiker, så er moral nemlig altid kun et udtryk for psykologi og kultur, også når det handler om for eksempel misbrug af børn i Tønder-sagen eller terror-angreb i Madrid, London og Mumbai ....
Betyder modellering det samme i naturfag som i matematik?
DEFF Research Database (Denmark)
Ejersbo, Lisser Rye
2014-01-01
Med de nye målformuleringer og læseplaner bruges udtrykket modellering nu både indenfor naturfag og matematik. Matematiklærere, som er vant til at arbejde med modellering tror måske, at det betyder det samme begge steder, men det behøver slet ikke at være tilfældet. Måske vi trænger til en...
DEFF Research Database (Denmark)
Hansen, Brian Benjamin; Bjerre, Henrik Jøker
fra den slovenske filosof Slavoj Zizek stilles imidlertid det spørgsmål i bogen, om ideologien idag ikke blot har taget en anden form. Vi lever i dag ikke i post-ideologiske tider. Snarere er braset selv – X Factor, forbrugsobjekter, underholdning, følelser og balloner – blevet den næsten usynlige...
DEFF Research Database (Denmark)
Sortkær, Bent
2017-01-01
Feedback bliver i litteraturen igen og igen fremhævet som et af de mest effektive midler til at fremme elevers præstationer i skolen (Hartberg, Dobson, & Gran, 2012; Hattie & Timperley, 2007; Wiliam, 2015). Dette på trods af, at flere forskere påpeger, at feedback ikke altid er læringsfremmende...... (Hattie & Gan, 2011), og nogle endda viser, at feedback kan have en negativ virkning i forhold til præstationer (Kluger & DeNisi, 1996). Artiklen vil undersøge disse tilsyneladende modstridende resultater ved at stille spørgsmålet: Under hvilke forudsætninger virker feedback i matematik læringsfremmende......? Dette gøres ved at dykke ned i forskningslitteraturen omhandlende feedback ud fra en række temaer for på den måde at besvare ovenstående spørgsmål....
DOĞAN, Nuri; BARIŞ, Fulya
2010-01-01
Bu araştırmada TIMSS–1999 ve TIMSS–2007 uygulamalarına giren Türk öğrencilerin bazı duyuşsalözelliklerinin matematik puanlarını yordama düzeyi incelenmiştir. TIMSS anketlerinde bulunan ve duyuşsalboyutları ölçen; tutum, değer ve öz-yeterlik puanları bağımsız değişken ve öğrencilerin matematik başarıpuanları bağımlı değişken olarak ele alınmıştır. Verilerin analizinde standart çoklu regresyon tekniğindenyararlanılmıştır. Analizler sonucunda, TIMSS-1999 ve TIMSS-2007 sınavlarında öğrencilerin m...
PENGARUH STRATEGI HEURISTIK VEE TERHADAP KEMAMPUAN PEMAHAMAN KONSEP MATEMATIK
Directory of Open Access Journals (Sweden)
Otong Suhyanto
2016-12-01
only design. Subyek penelitian ini adalah 55 mahasiswa yang terdiri dari 28 mahasiswa kelompok eksperimen dan 27 mahasiswa kelompok kontrol yang diperoleh dengan teknik cluster random sampling. Kemampuan pemahaman konsep matematik mahasiswa dikumpulkan dengan menggunakan tes essay. Hasil penelitian mengungkapkan bahwa kemampuan pemahaman konsep matematik mahasiswa yang diajar dengan strategi pembelajaran heuristik vee lebih tinggi dari pada kemampuan pemahaman konsep matematika mahasiswa yang diajar dengan strategi pembelajaran konvensional. Hal ini dapat dilihat dari nilai rata-rata hasil tes kemampuan pemahaman konsep matematik mahasiswa yang diajar dengan strategi pembelajaran heuristik vee sebesar 83,96 dan nilai rata-rata hasil tes kemampuan pemahaman konsep matematik mahasiswa yang diajar dengan strategi pembelajaran konvensional sebesar 78,3.
DEFF Research Database (Denmark)
Gimpel, Denise; Nielsen, Bent
2006-01-01
Hvorfor faldt Kina bagud i kapløbet med Vesten?« spørger David Favrholdt i sidste nummer af Weekendavisen. Var der overhovedet noget kapløb? Forudsætter et kapløb ikke, at man har et fælles mål? Spørgsmålet implicerer, at Vesten har vundet og indplacerer samtidig klodens øvrige kulturer i forhold....... Som en af 1900-tallets største sinologer A. C. Graham skriver i sin bog Disputers of the Tao (La Salle, Ill., 1989) var den videnskabelige revolution »en unik og kompleks begivenhed, som var afhængig af en mangfoldighed af sociale og andre betingelser, herunder et sammenfald af opdagelser (græske......, indiske, kinesiske, arabiske, næsten ingen romerske) koncentreret om kombinationen af indiske tal og aritmetik og græsk logik og geometri« (s. 317). En unik begivenhed, som er forekommet én gang i verdenshistorien. Det giver derfor ingen mening at spørge, hvorfor det ikke skete andre steder. Hvis det var...
En hat er vel en hat ... eller?
DEFF Research Database (Denmark)
Bøilerehauge, Dorrit
2007-01-01
Mens vi kører i høj fart på "the information highway" - i den helt store bus midt på vejen - glemmer vi ofte noget meget vigtigt i vores glæde over, at verden tilsyneladende åbner sig for os, og vi kan kommunikere med hele verden med ét klik. Vi glemmer, at selvom trafikskilte som oftest er ens -...... - så er selve trafikken og forventningerne blandt medtrafikanterne helt forskellige fra det, vi er vant til. Udgivelsesdato: Februar...
Hvad litteraturen kan, er ofte det rigtige ..
DEFF Research Database (Denmark)
Bundsgaard, Jeppe; Kühn, Lisbet
2010-01-01
Læsning i dansk handler i første omgang om at blive god til at læse, men på mellemtrinnet er det ved at være tiden til også at bruge skønlitteraturen til det, den er god til, nemlig til at få indsigt i menneskelivets kompleksitet. I dette kapitel anbefales det at gøre noget med litteraturen, fx f...
Er kollaborativ læring noget der findes - eller bare noget vi taler om?
Directory of Open Access Journals (Sweden)
Anne Ejsing
2003-05-01
Full Text Available
Første gang publiceret i UNEV nr. 1: Undervisningsformer på nettet, november 2003, red. Simon Heilesen og Helle Bækkelund Jensen. ISSN 1603-5518.
Hvad foregår der, når studerende arbejder i grupper? I almindelighed ved vi det ikke og kan kun bedømme resultatet i form af oplæg, opgaver, rapporter og procesbeskrivelser. Når gruppearbejdet foregår computermedieret - f.eks. som CSCL (Computer Supported Collaborative Learning - har man dog på grund af den skriftlige kommunikations permanens en enestående chance for at iagttage hvad der er foregået, og vurdere både samarbejdet og den læring, der kan spores. I artiklen undersøges samarbejde, refleksion og læring i en gruppekonference i konferencesystemet FirstClass (FC ud fra både en teoretisk og en empirisk nysgerrighed: Hvad er den læringsteoretiske baggrund for at hævde værdien af gruppearbejde, og kan man påvise et refleksivt læringspotentiale i computermedieret gruppearbejde empirisk?
Er kollaborativ læring noget der findes - eller bare noget vi taler om?
Directory of Open Access Journals (Sweden)
Anne Ejsing
2003-03-01
Full Text Available Første gang publiceret i UNEV nr. 1: Undervisningsformer på nettet, november 2003, red. Simon Heilesen og Helle Bækkelund Jensen. ISSN 1603-5518. Hvad foregår der, når studerende arbejder i grupper? I almindelighed ved vi det ikke og kan kun bedømme resultatet i form af oplæg, opgaver, rapporter og procesbeskrivelser. Når gruppearbejdet foregår computermedieret - f.eks. som CSCL (Computer Supported Collaborative Learning - har man dog på grund af den skriftlige kommunikations permanens en enestående chance for at iagttage hvad der er foregået, og vurdere både samarbejdet og den læring, der kan spores. I artiklen undersøges samarbejde, refleksion og læring i en gruppekonference i konferencesystemet FirstClass (FC ud fra både en teoretisk og en empirisk nysgerrighed: Hvad er den læringsteoretiske baggrund for at hævde værdien af gruppearbejde, og kan man påvise et refleksivt læringspotentiale i computermedieret gruppearbejde empirisk?
PENGARUH E-LEARNING UNTUK MENINGKATKAN DAYA MATEMATIK MAHASISWA
Directory of Open Access Journals (Sweden)
R. Poppy Yaniawati
2013-01-01
Full Text Available Abstrak: Pengaruh E-learning untuk Meningkatkan Daya Matematik Abstrak: Pengaruh E-learning untuk Meningkatkan Daya Matematik Mahasiswa. Peran integrasi teknologi pada pembelajaran modern cukup penting guna terjadinya proses percepatan dalam peningkatan daya matematika (mathematical power secara optimal. Penelitian ini mengungkapkan pengaruh e-learning untuk meningkatkan daya matematika. Subjek penelitian ini adalah mahasiswa semester IV pada dua level LPTK yang berbeda. Teknik pengumpulan data dengan tes dan teknik analisis data dengan statistik anova dua jalur. Berdasarkan hasil analisis data, diperoleh bahwa daya matematika mahasiswa yang pembelajarannya melalui blended learning lebih baik dibandingkan melalui full e-learning dan konvensional. Tetapi, daya matematika mahasiswa yang pembelajarannya melalui full e-learning kurang baik dibandingkan melalui pembelajaran konvensional. Dengan demikian, peran guru dalam pembelajaran matematika tidak dapat tergantikan oleh teknologi informasi. Terdapat korelasi yang signifikan antara daya matematik dengan pengetahuan awal, tetapi tidak terdapat korelasi yang signifikan antara daya matematik dan durasi login. Kata Kunci: e-learning, daya matematik, blended learning Abstract: Influence of E-learning to Improve Students’ Mathematical Power. The role of technology on modern learning is essential to the acceleration process in the improvement of mathematical power. This research describes the influence of elearning to improve mathematical power. The subject is the fourth semester students at two Universities. The results show that students who learned through blended learning method are much better in mathematical power than students who learned through full e-learning or conventional approaches. Furthermore, students who learned through e-learning are worse than students used conventional method. Therefore, this indicates that the role of teachers in the mathematics learning process can not be replaced
DEFF Research Database (Denmark)
Parby, Jakob; Thelle, Mikkel
2011-01-01
Nytænkning. Med de moderne megabyer er det slut med at forestille sig byen som noget, man planlægger og giver form. Vi skal lære at se dem som vildtvoksende urbane landskaber. Artikel om megabyer, byudvikling og forestillingen om byen gennem tiderne. Skrevet delvist i anledning af åbningen af...... udstillingen Citambulos på Københavns Museum, der handlede om Mexico City....
Selskaberne er en del af staten
DEFF Research Database (Denmark)
Hein Jessen, Mathias
2016-01-01
Lækket af Panama Papers fremhæver endnu engang den paradoksale rolle, ikke mindst multinationale selskaber spiller i politik og økonomi: De er både skabt af staten, og fremstår stadig som uden for og i opposition til staten. Hvis vi vil gøre noget ved problemet, må vi forstå, hvordan stat og...
Pædagogisk neurovidenskab: hvad er pædagogisk neurovidenskab og hvad skal den bruges til?
DEFF Research Database (Denmark)
Steffensen, Bo; Ejersbo, Lisser Rye
2014-01-01
matematik og læsning. Pædagogikken lever imidlertid stadigvæk i høj grad sit eget liv, fortsætter han, Klingbergs bog er oversat til engelsk, men ikke til dansk, hvilket er symptomatisk for den mindre interesse i Danmark for pædagogisk neurovidenskab. Dette temanummer har derfor til hensigt at vise, hvad...
DEFF Research Database (Denmark)
Widell, Peter
2012-01-01
artiklen er et bidrag til belysningen af genteori og bygger på ideen om at karakterisere skønlitteratur som et restringeret sæt af universelle tekstparametre. Artiklen fokuserer især på parametren tekstfiktion, hvor jeg forsvarer den position, at en fiktiv tekst hverken kan karakteriseres som en ...... intentioner. Det betyder dog ikke, at sandhed og mening ikke spiller noget rolle ved identifikationen af fiktion, sådan som det hævdes af Walsh og andre....
KEEFEKTIFAN MODEL PjBL DENGAN TUGAS CREATIVE MIND-MAP UNTUK MENINGKATKAN KONEKSI MATEMATIK SISWA
Directory of Open Access Journals (Sweden)
Zulfa Ainurrizqiyah
2015-08-01
Full Text Available Tujuan penelitian ini adalah untuk mengetahui peningkatan kemampuan koneksi matematik, apakah terdapat perbedaan serta manakah yang lebih baik antara pembelajaran dengan model PjBL dengan tugas creative mind-map dan pembelajaran ekspositori pada siswa kelas X materi Trigonometri. Penelitian eksperimen yang dilakukan dengan pre and posttest control group design ini memiliki populasi yakni siswa kelas X SMAN 1 Sukorejo tahun ajaran 2014/2015. Dengan menggunakan cluster random sampling, terpilih sampel yaitu siswa kelas XB sebagai kelas kontrol dengan pembelajaran ekspositori dan XC sebagai kelas eksperimen dengan model PjBL dengan tugas creative mind-map. Data kemampuan koneksi matematik dianalisis menggunakan uji proporsi, uji beda rata-rata. Berdasarkan uji proporsi, diperoleh lebih dari 75 % siswa kelas eksperimen mencapai nilai ketuntasan belajar, yaitu 75. Selain itu, diperoleh adanya perbedaan hasil kemampuan koneksi matematik antar kedua kelas dimana kelas eksperimen lebih baik daripada siswa kelas kontrol. Sedangkan untuk peningkatan menggunakan uji t berpasangan dan gain ternormalisasi dengan hasilnya yaitu terdapat peningkatan kemampuan koneksi matematik pada kelas eksperimen dengan kriteria tinggi.
Er frække reklamer forførende - eller bare spildte anstrengelser?
DEFF Research Database (Denmark)
Hermansen, Judy
2009-01-01
Det er blevet mere og mere almindeligt at reklamebranchen prøver kræfter med konventionerne for at tiltrække sig opmærksomhed. De kontroversielle reklameudformninger giver da også ofte noget presseomtale, men hvordan virker de egentlig i forhold til forbrugerne? I undersøgelsen af, hvordan...
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Baki ŞAHİN
2013-04-01
Full Text Available Bu araştırmanın amacı Muğla Üniversitesi Eğitim Fakültesinde okuyan öğretmen adaylarının “Matematik Öğretmeni”, Matematik” ve “Matematik” dersi kavramlarına yönelik algılarını oluşturan metaforları belirlemektir. Araştırmaya anket maddelerinin oluşturulma sürecinde iki branştan toplam 76 ve oluşturulan anket maddelerini cevaplandırmak için de dokuz farklı branştan toplam 1185 öğretmen adayı katılmıştır. Araştırmada nitel ve nicel ölçme araçları kullanılmıştır. Elde edilen sonuçlara göre üç kavramda da öğrencilerin algılarının branşlara göre farklılaştığı görülmüştür. “Matematik Öğretmeni” kavramı en çok “Bilgili” ve “Otoriter” metaforlarıyla algılanmaktadır. “Matematik Öğretmeni” kavramı, ilköğretim matematik öğretmeni ve lise matematik öğretmeni olarak iki farklı şekilde düşünüldüğünde, algılanan metaforların da değiştiği fark edilmiştir. “Matematik” kavramı “Zeka”, “Zevkli”, “Gerekli”, “Yetenek”, “Zor”, “Başarı” metaforlarıyla ilişkilendirilmiştir. En az tercih edilen metaforlar ise, “Gereksiz”, “Kolay” ve “Otorite” olmuştur. Matematik Derslerini algılama metaforları açısından anabilim dalları öğrencilerinin üç gruba ayrıldığını göstermektedir. Fen, Sınıf ve Okul Öncesi Öğretmenli öğrencileri “Matematik Dersi” kavramını olumlu metaforlarla ilişkilendirmekte; Almanca, İngilizce ve Türkçe Öğretmenliği öğrencileri kısmen olumlu, özellikle lise yıllarında olumsuz algı oluştururken; Müzik, Resim ve Sosyal Bilgiler Öğretmenliği öğrencileri en olumsuz, özellikle de lise yıllarında matematik dersini olumsuz algılamışlardır.
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Dian Anggraeni
2013-02-01
Full Text Available Makalah ini melaporkan temuan satu eksperimen dengan disain pretest-postest dengan kelompok kontrol dan menerapkan pendekatan kontekstual dan strategi formulate-share-listen-create (FSLC, untuk menelaah kemampuan pemahaman dan komunikasi matematik siswa SMK. Subyek penelitian ini adalah 80 siswa SMK program keahlian pemasaran di Bandung. Instrumen penelitian terdiri dari tes kemampuan pemahaman dan komunikasi matematik serta disposisi matematik. Berdasarkan analisis data menggunakan SPSS 16.0 dan Microsoft Excel 2010, penelitian menemukan: Pencapaian dan peningkatan kemampuan pemahaman dan komunikasi matematik siswa yang memperoleh pendekatan kontekstual dan strategi formulate-share-listen-create (FSLC lebih baik daripada pencapaian dan peningkatan kemampuan siswa yang memperoleh pembelajaran konvensional. Penelitian juga menemukan adanya asosiasi sedang antara kemampuan pemahaman dan komunikasi matematik, dan siswa menunjukkan disposisi matematik yang positif terhadap pendekatan kontekstual dan strategi formulate-share-listen-create (FSLC Kata Kunci : pendekatan kontekstual, strategi formulate-share-listen-create, pemahaman dan komunikasi matematik, disposisi matematik This paper reports the findings from an experimental prettest-posttest control group design conducted by using contextual approach and formulate-share-listen-create (FSLC strategy to investigate students’ mathematical understanding and communication abilities.The study involved 80 grade-11 students from SMK of marketing field program in Bandung. The instrumens of this study are mathematical undestanding test, mathematical communication test, and mathematical disposistion scale. By using SPSS 16.0 and Microsoft Excel 2010, the study found the contextual approach and formulate-share-listen-create (FSLC strategy was able to improve students’ mathematical understanding and mathematical communication abilities better than that of conventional approach. Students
Povijesni pregled implementacije matematike i statistike u ekonomiju
Crnjac Milić, Dominika; Martinović, Martina
2012-01-01
U ovom preglednom članku dat ćemo kratki povijesni pregled implementacije matematike i matematičkih disciplina u kvantitativnu ekonomiju. Kronološki ćemo pokazati razvoj matematičkih metoda i njihovu primjenu u ekonomiji. Posebnu ćemo pozornost posvetiti ekonometrijskom razvoju.
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Hamdan Sugilar
2013-09-01
Full Text Available Penelitian ini merupakan penelitian kuasi eksperimen dengan disain kelompok kontrol tidak ekivalen karena tidak adanya pengacakan dalam menentukan subjek penelitian. Peneliti tidak membentuk kelas baru berdasarkan pemilihan sampel secara acak. Subjek sampel diambil dua kelas dari kelas VII siswa MTs Negeri Cikembar Kabupaten Sukabumi, satu kelas sebagai kelas eksperimen dengan pembelajaran generatif dan satu kelas sebagai kelas kontrol dengan pembelajaran konvensional. Instrumen yang digunakan adalah tes dan non tes. Hasil studi penelitian ini adalah: 1 peningkatan kemampuan berpikir kreatif siswa yang mengikuti pembelajaran generatif lebih baik daripada siswa yang mengikuti pembelajaran matematika secara konvensional ditinjau dari pencapaian hasil belajar dan peningkatan kemampuan berpikir kreatif. Kemampuan berpikir kreatif kelas eksperimen termasuk pada kategori sedang sedangkan kelas kontrol termasuk kategori rendah.2 terdapat perbedaan peningkatan kemampuan berpikir kreatif matematik antara siswa kemampuan tinggi, sedang, dan rendah yang mendapat pembelajaran generatif, 3 disposisi matematik siswa yang mengikuti pembelajaran matematika melalui pembelajaran generatif lebih baik daripada siswa yang mengikuti pembelajaran matematika secara konvensional, disposisi matematik siswa pada kelas eksperimen termasuk pada kategori sedang, sedangkan pada kelas kontrol disposisi matematik termasuk pada kategori rendah. 4 terdapat interaksi antara model pembelajaran dan tingkat kemampuan awal siswa dalam menghasilkan kemampuan berpikir kreatif. 5 terdapat asosiasi antara kemampuan berpikir kreatif matematik dengan disposisi matematik, kategori asosiasinya tinggi. Kata Kunci : Pembelajaran Generatif, Berpikir Kreatif, Disposisi Matematik This research quasi-experiment with design controls not equivalent as there is not a beating in determining the subject research. Researchers does not set up new class based on the election samples randomly. The
Directory of Open Access Journals (Sweden)
Rijal Darusman
2014-09-01
Full Text Available ABSTRAK Masalah yang melatar belakangi penelitian ini adalah masih rendahnya kemampuan berpikir kreatif matematik siswa Sekolah Menengah Pertama (SMP, sehingga diperlukan metode pembelajaran untuk mengatasi masalah tersebut. Metode yang diterapkan adalah Metode Mind Mapping, dikarenakan dengan metode pembelajaran mind mapping kemampuan berpikir kreatif matematik siswa lebih baik jika dibandingkan dengan metode pembelajaran biasa.Berdasarkan latar belakang tersebut maka penelitian ini bertujuan untuk mengetahui apakah kemampuan berpikir kreatif matematik siswa yang pembelajarannya menggunakan metode mind mapping lebih baik daripada siswa yang pembelajarannya biasa. Penelitian ini merupakan kuasi eksperimen berbentuk kelompok kontrol pretes-postes, dengan perlakuan metode pembelajaran mind mapping dan pembelajaran biasa (konvensional. Pengumpulan data dalam penelitian ini berupa tes uraian sebanyak 4 soal, kemudian data skor kemampuan berpikir kreatif matematik siswa tersebut dianalisis dengan statistik deskriptif dan inferensial dengan menggunakan uji perbedaan dua rata-rata. Berdasarkan hasil analisis data diperoleh kesimpulan bahwa peningkatan kemampuan berpikir kreatif matematik siswa SMP yang pembelajarannya menggunakan metode mind mapping lebih baik daripada cara biasa. Kata Kunci : Berpikir Kreatif Matematik, Mind Mapping ABSTRACT The problem of the background of this research is still low ability to think creatively mathematical school students (SMP, so that the necessary learning methods to overcome these problems. The method applied is Mind Mapping method, because the mind mapping method of learning mathematics students' creative thinking ability is better when compared to the learning method biasa.Berdasarkan this background, this study aims to determine whether the ability of creative thinking of students learning mathematics using mind mapping better than the usual student learning. This research is a form of quasi
Er Foucault en middelalderlige skamfuld eller ukritisk tænker?
DEFF Research Database (Denmark)
Staunæs, Dorthe; Raffnsøe, Sverre
2018-01-01
Ifølge Per Aage Brandt indeholder et ikke før udgivet interview med Foucault nøglen til den franske filosofs værk, som »ingen har kunnet finde hoved eller hale på«. Men hvem er det, der ikke kan det? Hvilken form for kritik kræver det at lære noget nyt? Og kan man undgå at begynde i fordommen...
Er Foucault en middelalderlig, skamfuld eller ukritisk tænker?
DEFF Research Database (Denmark)
Raffnsøe, Sverre; Staunæs, Dorthe
2018-01-01
Ifølge Per Aage Brandt indeholder et ikke før udgivet interview med Foucault nøglen til den franske filosofs værk, som »ingen har kunnet finde hoved eller hale på«. Men hvem er det, der ikke kan det? Hvilken form for kritik kræver det at lære noget nyt? Og kan man undgå at begynde i fordommen?...
Forbrugerens sjæl og branding med succes
DEFF Research Database (Denmark)
Hermansen, Judy
2008-01-01
Branding er en slags besjæling af produkter - det er at tage en genstand, som bare er et fysisk, funktionel ting og så få den til at betyde noget for nogen. Det, der karakteriserer brands er netop, at vi føler noget overfor dem. Det kan godt være vi føler afsky - men vi føler noget. Og vi inddrag...
Okulöncesi Öğretmenlerinin Erken Matematik Eğitimine İlişkin Özyeterlikleri
ÇELİK, Meryem
2017-01-01
Bu araştırmanın amacı, okulöncesi öğretmenlerinin erken matematik eğitimine ilişkin özyeterlik düzeyleri ve bu düzeylerle çeşitli değişkenler arasındaki ilişkileri incelemektir. Araştırmanın örneklemini oluşturan 2013 yılında okulöncesi öğretmenliği yapan 60 öğretmene “Okulöncesi Öğretmenlerinin Erken Matematik Eğitimine İlişkin Yeterliklerini Belirleme Aracı” uygulanmıştır. Analizler sonucunda öğretmenlerin erken matematik eğitimine ilişkin yeterlilik düzeylerinin iyi olduğu sonucuna ulaşılm...
DEFF Research Database (Denmark)
Eckholdt, Annette; Winding, Anne; Krogh, Paul Henning
2017-01-01
Ordet "biodiversitet" og at det er noget, vi skal have mere af, nævnes hyppigt. Men hvad er biodiversitet, og hvordan måles det? Agrologisk har bedt et par eksperter fra Aarhus Universitet forklare, hvordan et DNA-aftryk af jord og vand kan erstatte optællinger i felten og sige noget om biodivers......Ordet "biodiversitet" og at det er noget, vi skal have mere af, nævnes hyppigt. Men hvad er biodiversitet, og hvordan måles det? Agrologisk har bedt et par eksperter fra Aarhus Universitet forklare, hvordan et DNA-aftryk af jord og vand kan erstatte optællinger i felten og sige noget om...
Directory of Open Access Journals (Sweden)
Emel Çilingir
2016-12-01
Full Text Available The aim of study was to investigate the effects of Realistic Mathematics Education (RME based instruction in the elementary mathematics curriculum on the mathematics achievement, Visual Mathematics Literacy Self Efficiency Perceptions (VMLSP and Mathematics Problem Solving Attitude (MPSA. The study was determined as a quasi-experimental study which conducted as a pre-posttest design with a control group. The research was conducted with 147 students at fourth grade of a public elementary school in Adana. In the study, the experimental group and one of the control group were instructed by one of the researchers, while in other control group was instructed by their teacher. „Geometric Shapes‟ unit was instructed with RME at the experimental group while the current instructional method was conducted to the control groups. The data were obtained with mathematics achievement tests and VMLSP and MPSA Scale which provided goodness according to the confirmatory factor analysis model. The quantitative data was evaluated by using mixed ANOVA and tTest methods. As a result, it was found that the students at the experimental group have more successful in mathematic achievement tests and more progress on VMLSP and MPSA than control group. [Araştırmanın amacı, ilkokulda Gerçekçi Matematik Eğitimi yaklaşımıyla gerçekleştirilen öğretimin, öğrencilerin matematik başarılarına, görsel matematik okuryazarlık özyeterlik algılarına ve matematik problemlerini çözmeye yönelik tutumlarına etkisini incelemektir. Bu amaçla öntest-sontest kontrol gruplu yarı deneysel bir çalışma yapılmıştır. Araştırma, Adana’daki bir devlet ilkokulunun 4. sınıfına giden 147 öğrenci üzerinde gerçekleştirilmiştir. Araştırmada deney grubunda ve iki kontrol grubundan birinde dersler araştırmacı tarafından diğer kontrol grubunda ise sınıfın öğretmeni tarafından yürütülmüştür. Deney grubunda ‘Geometrik Şekiller’
DEFF Research Database (Denmark)
Togeby, Ole
2005-01-01
Repræsentationer (tegn) defineres som noget der for nogen angiver noget som de er udformet til at angive. Repræsentationer indebærer intentionalitet, som er defineret ved at være OM noget og ved muligheden for misrepræsentation. Der skelnes mellem ydre repræsentationer (tekster og billeder) og in...
NÅR NOGEN LER, ER DER NOGET PÅ SPIL
DEFF Research Database (Denmark)
Volf, Mette
2012-01-01
idégenerering. I den del, der omhandler designprocessen set som et socialt fænomen, beskriver jeg praksis som interaktioner, som dels skaber situationelle betydninger, dels afdækker normer, som er internalise-rede, og som således fremstår som sandheder i designprofessionen. Jeg argumenterer her for, at sociale...... hierarkier har en betydning for, hvordan designprocesser forløber, hvem der betragtes som kreativ, og hvem der ikke gør. Endvidere gør jeg rede for, at designerne optræder i forskellige roller i idégenereringsfaser – og at humor her spiller en væsentlig rolle – som gør, at normalverdenens sociale hierarkier......, kognitiv designtænkningsteori for dels at gøre rede for en af de herskende tilgange på området, dels for at kunne positionere mig i forhold hertil og efterfølgende præsentere min tilgang til designprocessen som et socialt fænomen med udgangspunkt i antropologiske og so-ciologiske teorier. Eftersom...
DEFF Research Database (Denmark)
Togeby, Ole
2005-01-01
Begrebet 'tegn' eller 'repræsentation' defineres som noget der for nogen angiver noget som det er udformet til at angive. Der skelnes dernæst mellem analoge og digitale repræsentationer, blandingsrepræsentationer og komplekse repræsentationer.......Begrebet 'tegn' eller 'repræsentation' defineres som noget der for nogen angiver noget som det er udformet til at angive. Der skelnes dernæst mellem analoge og digitale repræsentationer, blandingsrepræsentationer og komplekse repræsentationer....
DEFF Research Database (Denmark)
Skott, Jeppe; Skott, Charlotte Krog; Jess, Kristine
DELTA 2.0 er en ny og helt opdateret udgave af Delta, der i ti år været brugt i matematiklærernes grund-, efter- og videreuddannelse. DELTA 2.0 er seriens almene fagdidaktik. Der er også fagdidaktiske overvejelser i de øvrige bøger i serien, men de er knyttet til specifikt matematisk indhold. DELTA...... 2.0 behandler mere generelle matematikdidaktiske problemstillinger såsom læringsteoretiske overvejelser i forbindelse med matematik, centrale aspekter af det at undervise i matematik og digitale teknologier som værktøj til at støtte elevers faglige læring af matematik....
DEFF Research Database (Denmark)
Hansbøl, Gorm
-as), idet der ikke er tale om at se børnene som nogle andre (ibid. s. 368). At se noget, som-om det er noget andet, er at se wireren som-om, den er en slange i betydningen et krybdyr, eller hvis børnene ses, som-om de er to abeunger, der morer sig. Denne indsigt rummer et stort didaktisk potentiale...
Math2Earth and the many faces of mathematics
DEFF Research Database (Denmark)
Andersen, Niels John
2010-01-01
Artiklen omhandler fagdidaktiske problemstillinger, der ofte dukker op i forbindelsen med matematik i anvendelse. Blandt andet er der en tendens til at matematik overses, når den er indlejret i en praktisk anvendelsessituation. Omvendt sker det ofte, at matematiske muligheder ikke udnyttes, hvor ...
Directory of Open Access Journals (Sweden)
Desy Kumalasari
2017-03-01
Full Text Available Penelitian ini bertujuan untuk mendeskripsikan kualitas pembelajaran matematika dalam setting problem based learning terhadap kemampuan pemecahan masalah siswa kelas XI SMK, mendeskripsikan tingkat kecemasan matematik siswa dalam mengikuti pelajaran matematika dalam setting problem based learning, dan mendeskripsikan kemampuan pemecahan masalah berdasarkan tingkat kecemasan matematik. Metode penelitian ini adalah mixed methods. Subjek dalam penelitian ini adalah siswa kelas XI TKKB SMKN 10 Semarang. Selanjutnya dipilih 6 siswa dari masing-masing kemampuan pemecahan masalah berdasarkan tingkat kecemasan matematik. Metode pengumpulan data dalam penelitian ini adalah metode observasi, dokumentasi, tes, dan wawancara. Analisis data dalam penelitian ini adalah analisis kualitas pembelajaran, analisis tingkat kecemasan matematik, analisis kemampuan pemecahan masalah, reduksi data, penyajian data, dan menarik kesimpulan dan verifikasi. Hasil penelitian ini diperoleh: kualitas pembelajaran dalam setting problem based learning dalam kategori baik, tingkat kecemasan matematik siswa kelas XI SMKN 10 Semarang sebelum pembelajaran matematika adalah rendah, pada saat kegiatan pembelajaran adalah tinggi, dan setelah kegiatan pembelajaran adalah rendah, untuk tingkat kecemasan sebelum tes kemampuan pemecahan masalah adalah rendah, dan setelah tes kemampuan pemecahan masalah adalah tinggi, dan kemampuan pemecahan masalah matematika siswa yang tingkat kecemasan matematik rendah lebih baik dari pada siswa yang tingkat kecemasan matematiknya tinggi. This research aimed to describe the quality of mathematics teaching in the setting of problem based learning to problemsolving ability of class XI student of SMK, the level of mathematics anxiety of students in participating in the setting math problem based learning, and the problemsolving abilities by mathematics anxiety levels. This research method is mixed methods. Subjects in this
Elvsén, Johanna
2006-01-01
Enligt Lpfö-98 skall man på förskolan arbeta med att barnen utvecklar sin förmåga att upptäcka och använda matematik i meningsfulla sammanhang. Jag tror att en förutsättning för en lyckad förskoleverksamhet är att man har föräldrarnas stöd och intresse i de aktiviteter som förekommer och har därför genom enkäter undersökt hur föräldrar uppfattar matematik i förskolan, viken inställning de har, samt deras eventuella tankar om utformningen. Detta har jämförts med den aktuella förskolans tankar ...
Nyt slankemiddel i håndkøb på markedet
DEFF Research Database (Denmark)
Astrup, Arne
2009-01-01
Har du hørt om det nye slankemiddel Alli, men er i tvivl om, det er noget for dig, så læs her, hvordan Alli virker Udgivelsesdato: 6. maj......Har du hørt om det nye slankemiddel Alli, men er i tvivl om, det er noget for dig, så læs her, hvordan Alli virker Udgivelsesdato: 6. maj...
DEFF Research Database (Denmark)
Andersen, Lars Pynt
2010-01-01
At snige sig uset gennem radarsystemerne er dog ikke kun noget der appellerer til luftvåbnet. Det er tilsyneladende også mere og mere væsentligt i markedskommunikation. Udgivelsesdato: 23.3.......At snige sig uset gennem radarsystemerne er dog ikke kun noget der appellerer til luftvåbnet. Det er tilsyneladende også mere og mere væsentligt i markedskommunikation. Udgivelsesdato: 23.3....
Virkelighed er noget vi leger frem, når vi leger med magten
DEFF Research Database (Denmark)
Holm, Claus
2008-01-01
I ny bog analyserer professor Niels Åkerstrøm Andersen fra CBS, hvordan organisationer forsøger at bruge den ellers uskyldige leg i magtens tjeneste. Men legen er ikke kun en loyal tjener, legen laver sine egne regler og risikerer at tage magten fra magthaverne, når de mægtiggør os gennem legen....
DEFF Research Database (Denmark)
Andersen, Niels John
2010-01-01
Sammenhængen mellem den abstrakte matematik i mange lærebøger og matematik i anvendelse er ikke altid lige let at få øje på. Artiklen drøfter nogle af de problemstillinger, der kan være med til skabe dette skel mellem undervisningsmatematik og matematik i arbejde....
Tema 1: Programmering af robotenheder i grundskolen
Directory of Open Access Journals (Sweden)
Stine Ejsing-Duun
2016-01-01
Full Text Available I denne artikel undersøger vi potentialerne for at lære matematik gennem programmering af robotter. Vi foreslår en model med tre indbyrdes afhængige læringspotentialer, som programmering fordrer. Det omfatter elevens evne til at; (1 tænke i algoritmer, (2 producere viden og artefakter gennem brug af matematik og (3 foretage abstraktion og indkapsling. Programmering er blevet en del af grundskolens læringsmål i flere lande. I Danmark er programmering et læringsmål i forenklede fælles mål for Fysik/Kemi og desuden en del af den nationale undervisningsvejledning for matematik. En analyse af potentialerne i at anvende programmering i forbindelse med disse fag er derfor væsentlig. I denne artikel fokuserer vi på samspillet mellem matematik og programmering gennem litteraturstudier og analyse af empiriske situationer fra undervisning i programmering af LEGO Mindstorms. Teoretisk anvendes den instrumentelle tilgang til teknologi i matematikundervisning. Analysen viser en række måder, hvorpå didaktisk opmærksomhed på epistemisk forhandling kan understøtte læring af matematik gennem programmering.
Den brede, folkelige debat om EU
DEFF Research Database (Denmark)
Dosenrode, Søren
2005-01-01
I Danmark er EUropa noget fjernt på trods af, at EU er rammen om dansk politik, både udenrigs og indenrigs. Danmark er medlem af en de facto føderation, men de brede folkelige debater om hvordan EU skal gestaltes har manglet.......I Danmark er EUropa noget fjernt på trods af, at EU er rammen om dansk politik, både udenrigs og indenrigs. Danmark er medlem af en de facto føderation, men de brede folkelige debater om hvordan EU skal gestaltes har manglet....
Jannok-Nutti, Ylva
2010-01-01
Syftet med föreliggande avhandling är att utifrån lärarperspektiv beskriva, analysera och försöka förstå transformering av utbildning i matematik så att ett samiskt perspektiv blir utgångspunkt för utbildningen. Avhandlingen genomfördes såsom ett aktionsforskningsprojekt med fokus på lärares perspektiv avseende transformering och genomförande av transformeringsaktiviteter i matematik. Teoretiska utgångspunkter togs utifrån Smiths teori om urfolksperspektiv, Banks teori för integrering av mult...
DEFF Research Database (Denmark)
Lützen, Jesper
2015-01-01
I moderne formalistisk matematik er ontologi blevet erstattet med spørgsmålet om konsistens af et aksiomatisk system. I artiklen gøres der rede for hvordan denne opfattelse er blevet til og denne historie opfattes i sig selv som en slags erstatning for ontologi......I moderne formalistisk matematik er ontologi blevet erstattet med spørgsmålet om konsistens af et aksiomatisk system. I artiklen gøres der rede for hvordan denne opfattelse er blevet til og denne historie opfattes i sig selv som en slags erstatning for ontologi...
DEFF Research Database (Denmark)
Hermansen, Judy
2009-01-01
Da et brand er en noget uhåndgribelig størrelse, kan opfattelsen af, hvad et brand egentlig er, variere noget blandt de forskellige chefer i en organisation, som har til opgave at øge brandets performans. Denne artikel ser på, hvordan brand fortolkninger har udviklet sig fra det funktionelle ti...
DEFF Research Database (Denmark)
Rösing, Lilian Munk
2017-01-01
Det er min tese, at Yahya Hassan både som digter og offentlig aktør åbner den modstandszone hinsides Loven, som Eric Santner forsøger at indkredse. At der er noget ved hans digtning, som sprænger tænkningen i identitetsprædikater. Noget, der bryder med Loven på en mere radikal og frugtbar måde end...
DEFF Research Database (Denmark)
Ejersbo, Lisser Rye; Steffensen, Bo
Matematikholdige tekster er en genre, som eleverne skal lære at læse, men der er mange spørgsmål forbundet med, hvad en sådan tekst består af. Hvordan læses teksterne, og hvor svært er det at læse en tekst bestående af både matematiske symboler og tekst? Hvornår er teksten autentisk? Er det...
DEFF Research Database (Denmark)
Hvass, Helle; Heger, Stine
2017-01-01
med temaet Feedback på tekst i grupper er via aktiviteter at gøre de studerende bevidste om, at feedback er noget, de skal lære, og noget, de skal øve sig på. De forskellige aktiviteter sætter de studerende i gang med at skabe rammer for feedback, at træne feedback og at give og modtage feedback på...... hinandens tekster. Temaet er bygget op omkring 2 forskellige elementer: 1) forberedelse af feedback og 2) udførelse af feedback....
DEFF Research Database (Denmark)
Braagaard Harders, Anne Katrine
2014-01-01
Cyklisme i fremtiden? Ja, helst, men det kræver måske, at vi er nødt til at holde op med at snakke om cyklisme som noget særligt og noget der skal behandles separat. Vi er nødt til at forstå mobilitet i byen i sin helhed, for hvert transportmiddel påvirker hinanden og byen og det gør deres...
Vi er ved at indføre en ny slags systemkontrol
DEFF Research Database (Denmark)
Booss-Bavnbek, Bernhelm
2016-01-01
Om forholdet mellem det formale og det sociale. Sindelagskontrol i 1970ernes Vesttyskland og dagens Danmark. Diskussionen mellem Alf Ross og Hal Koch. En tysk matematikers syn.......Om forholdet mellem det formale og det sociale. Sindelagskontrol i 1970ernes Vesttyskland og dagens Danmark. Diskussionen mellem Alf Ross og Hal Koch. En tysk matematikers syn....
KMD Education i læreruddannelsen
DEFF Research Database (Denmark)
Skovmand, Keld
2014-01-01
Artiklen er en del af afrapporteringen af et projekt vedr. brugen af det digitale planlægningsværktøj KMD Education i læreruddannelsen. Projektet var finansieret af Undervisningsministeriet og omfattede forløb i dansk og matematik......Artiklen er en del af afrapporteringen af et projekt vedr. brugen af det digitale planlægningsværktøj KMD Education i læreruddannelsen. Projektet var finansieret af Undervisningsministeriet og omfattede forløb i dansk og matematik...
DEFF Research Database (Denmark)
Hansen, Brian Benjamin; Thykjær, Steen
2010-01-01
Vi lever i en ualmindelig stresset verden. Faktisk er stress i dag noget, som vi slet ikke kan undvære, fordi vi ellers ikke tæller som vigtige, spændende og skabende mennesker. Og selv den terapi, som skulle kurere stressen, bidrager til den, ved at være handlingsorienteret. Måske skal vi tænke...... meget mere radikalt, hvis vi for alvor ønsker at ændre ved koordinaterne for det moderne liv? Måske er der noget at hente i kedsomheden og den form for terapi, hvis eneste våben er sofaen? ...
Jyske banker til kaffe hos Lizette
DEFF Research Database (Denmark)
Ørholst, Henrik
2018-01-01
En fusion mellem Sydbank, Jyske Bank og Spar Nord vil kunne skabe et stærkt alternativ til Danske Bank og Nordea, men det er næppe realistisk. Her kunne bankerne lære noget af LO og FTF.......En fusion mellem Sydbank, Jyske Bank og Spar Nord vil kunne skabe et stærkt alternativ til Danske Bank og Nordea, men det er næppe realistisk. Her kunne bankerne lære noget af LO og FTF....
Robusthed er noget betjente skaber sammen
DEFF Research Database (Denmark)
Mogensen, Mette; Mikkelsen, Elisabeth Naima
2018-01-01
Kriminalforsorgen lægger vægt på at tiltrække ’folk af den rette støbning’. Men når Man fokuserer på den enkelte betjents karaktertræk, trænger man en væsentlig dimension Ved betjentjobbet i baggrunden: nemlig betydningen af et velfungerende teamsamarbejde.......Kriminalforsorgen lægger vægt på at tiltrække ’folk af den rette støbning’. Men når Man fokuserer på den enkelte betjents karaktertræk, trænger man en væsentlig dimension Ved betjentjobbet i baggrunden: nemlig betydningen af et velfungerende teamsamarbejde....
DEFF Research Database (Denmark)
Andersen, Tem Frank
2015-01-01
"50 ÅR EFTER har vi naturligvis rykket os noget på det punkt, hvad de kønspolitiske debatter viser. Er man hyppig bruger af Instagram, bliver det hurtigt klart, at vores kultur, i dette årtusinde, stadig har mange bøfler."......"50 ÅR EFTER har vi naturligvis rykket os noget på det punkt, hvad de kønspolitiske debatter viser. Er man hyppig bruger af Instagram, bliver det hurtigt klart, at vores kultur, i dette årtusinde, stadig har mange bøfler."...
DEFF Research Database (Denmark)
Berliner, Peter; Glendøs, Mia
2010-01-01
Den høje voldsrate i Kalaallit Nunaat (Grønland) forklares ofte ud fra alkoholmisbrug og affektive handlinger. I denne artikel vises det gennem en kvantitativ og kvalitativ undersøgelse, at den episodiske vold må forstås som symptomer på strukturel vold. Den strukturelle vold er en kontekst, der ...
DEFF Research Database (Denmark)
Uddannelse er ikke noget, du får, men noget, du tager. Det kræver planlægning, engagement, samarbejde og en vilje til gensidig forpligtelse. GOD VIDEREUDDANNELSE sætter fokus på en række væsentlige temaer, som du må forholde dig til for at få et godt udbytte af et videreuddannelsesforløb. Bogen...
Enterprise 2.0 - hvordan får du succes?
DEFF Research Database (Denmark)
Ivang, Reimer
2009-01-01
Det seneste år til halvandet har der været konstant stigende fokus og interesse for begrebet Enterprise 2.0. En interesse som kan ses af den konstant stigende litteratur som beskæftiger sig med emnet. Men er det noget for dig, for din organisation? Få svaret her.......Det seneste år til halvandet har der været konstant stigende fokus og interesse for begrebet Enterprise 2.0. En interesse som kan ses af den konstant stigende litteratur som beskæftiger sig med emnet. Men er det noget for dig, for din organisation? Få svaret her....
Origami ile Matematik Öğretimi/Teaching Mathematic With Origami
Polat, Seyat
2013-01-01
Özet Bu çalışmada; origami etkinliklerinin matematik dersinde kullanılması ile ilgili olarak, origaminin ilişkili olduğu konular, origami uygulamaları ile ilgili öğrenci görüşleri, origami yapılırken en çok zorlanılan şekiller ve origami uygulamaları sürecinde öğrenciler için görselleşen terimler incelenmiştir. Nitel olarak desenlenen çalışma ilköğretim 4 ve 5. sınıfa devam eden 17 öğrenciyle gerçekleştirilmiştir. Veriler yarı yapılandırılmış görüşme yöntemiyle toplanmıştır. Elde edilen bulgu...
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Ferhan Bingölbali
2016-08-01
Full Text Available How teachers read or interpret textbooks, which represent curricula, is important for successful implementation of curricula (the level of reading of knowledge, skills and values in the textbooks that curriculum sets forth for students’ learning. This paper aims to investigate how middle school mathematics teachers read mathematics textbooks in the light of goals of middle school mathematics curriculum. To this end, a 5th grade mathematics textbook’s segment which covers one learning objective about simplifying and expanding fractions is given to 30 middle school mathematics teachers and they are asked this following question: “What do think that the textbooks writers pay attention for teaching of this learning objective?” The findings reveal that the teachers did not read such mathematical process skills as reasoning, making connection, and communication which were reflected into the learning objective in the textbook. The findings also show that the teachers mainly read the textbooks by “describing what is done”, “providing suggestion”, and “pointing out short comings” and these suggest that this type of reading is rather superficial as far as the teaching that the curriculum aims to achieve is concerned. The paper draws attention to the issues regarding how the textbook reading skills of mathematics teachers can be developed and presents some implications about textbook research. [Öğretim programlarının bir yansıması konumunda olan ders kitaplarını öğretmenin nasıl okuduğu (programın öngördüğü bilgi, beceri ve değer hedeflerini kitaplarda okuyup okumadığı, vb. davranışlar programın başarıya ulaşmasında önem arz eder. Bu çalışmada ortaokul matematik öğretmenlerinin matematik ders kitaplarını nasıl okuduklarının, öğretim programlarının hedefleri doğrultusunda incelenmesi amaçlanmaktadır. Bunun için 30 ortaokul matematik öğretmenine kesirlerde sadeleştirme ve genişletme ile
DEFF Research Database (Denmark)
Helms, Niels Henrik
2012-01-01
Kravet om innovation og kreativitet er på flere måder en stor og en ny udfordring for voksenuddannelserne. Det udfordrer det didaktiske dilemma, det at vi skal gøres til kompetente og frie mennesker gennem pædagogiske handlinger, som netop pålægger os en ufrihed. – Men hvor denne ufrihed tidligere...... kunne begrundes med, at skolen eller uddannelsen vidste bedre, så er det ikke længere tilfældet. Skolen skal sørge for, at vi lærer noget – og ikke noget andet. Men det kan ikke længere med bestemthed afgøres, hvad det er vi skal lære i skolen, fordi det nye, det kreative og ikke mindst innovative...
Bio-Matematik ved Roskilde Universitet
DEFF Research Database (Denmark)
Ottesen, Johnny T.
2010-01-01
findes i monografierne "Applied Mathematical Models in Human Physiology", "Mathematical Modeling in Medicine", og i "The Biomedical Engineering Handbook". Arbejdet med at udvikle anæstesisimulatorerne satte gang i en mængde "sundhedsmatematik" på instituttet og i dag huser instituttet desuden phd......-programmet "Mathematical modeling and its mathematical prerequisites" ledet af undertegnet. Programmet er associeret med den nationale phd-skole "Research School for Mathematics and Applications". BioMath-gruppens fokusområder er bl.a. 1) Kardiovaskulær fysiologi og dets kontrolmekanismer; 2) Fluiddynamik og klapløse......-trivielle eksperimenter, kan tjekke om tanker og hypoteser holder og er konsistente samt kan benyttes til at konstruere nye diagnosticerings- og behandlingstilbud, gør at de nævnte metaaspekter er ikke-trivielle aspekter og illustrerer samtidig modelleringslandskabets komplekse moras. I artiklen forsøger vi...
DEFF Research Database (Denmark)
2011-01-01
website: www.pss-comenius.eu foto, filmklip, lektionsplaner til fag (idræt,samfundsfag, matematik, engelsk) og til emner (konfliktløsning, selvværd, forhandling og kompromis) Materialet er et samarbejde under EU. samarbejdsparter er fra Italien, Polen Bulgarien, Storbritannien og Danmark. Website...
Making ends meet. A synthesis of research on consumer behaviour and the environment
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Thøgersen, John
1999-01-01
litteratur. Især to diskussioner er mere udfoldede i denne sammenfatning end noget andet sted i disputatsen. Den ene er diskussionen om, hvordan mit teoretiske bidrag adskiller sig fra markante forgængere, især Icek Ajzens Theory of Planned Behaviour. Den anden er diskussionen af mine analysers...
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Kjems, Erik
2015-01-01
BIM er et udtryk de fleste er stødt på i forbindelse med deres erhverv. Det er meget udbredt i byggesektoren, men knap så kendt i vejsektoren. I det følgende vil det blive forsøgt at forklare begrebet, baggrunden og indholdet herfor, og hvorfor det er noget alle bør tage stilling til inden for en...
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Søndergaard, Dorte Marie
2009-01-01
Hvordan går det til, at Anders havner i hjørnet af bruserummet efter idrætstimerne, mens de andre drenge i klassen spuler ham med koldt vand fra vandslangen på væggen? Er det Anders, der er noget galt med? Eller er det de andre drenge? Eller er fejlen i virkeligheden pedellens? Han har jo skruet ...
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Nøhr Christensen, Rikke; Bengtsson, Steen
Mange mennesker er i forskelligt omfang berørt af psykisk lidelse, men alligevel er psykisk lidelse ikke noget, vi er gode til at tale om og få sat på dagsordenen i den offentlige debat. Det skyldes bl.a., at psykisk lidelse er behæftet med en række fordomme, tabuer og ikke mindst uvidenhed. Vi v...
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Brøgger, Ditte Rasmussen
2016-01-01
Migration er ikke noget nyt fænomen, men det er et fænomen i konstant forandring – både kvantitativt og kvalitativt. Mennesker har nemlig altid bevæget sig. Tag f.eks. jæger-samlerfolket, der var cirkulære migranter, størstedelen af USA’s befolkning, som de fleste nok er bekendte med er...
Tænk ikke, men se efter! - Wittgensteins brug af eksemplet
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Krause-Jensen, Niels Henrik
2016-01-01
I dette kapitel er ærindet at præsentere en filosofisk metode, som på en langt mere gennemgribende måde end vanligt orienterer sig efter eksempler. Udgangspunktet er sprogfilosoffen Ludwig Wittgensteins tænkning, hvor det vises, at der er noget ganske særligt på spil: Eksempler bruges ikke til...
DEFF Research Database (Denmark)
2011-01-01
PowerPoint præsentation, der er brugt i forbindelse med et oplæg som blev holdt for alle matematiklærere i Helsingør Kommune, som opstart på kommunens projekt, hvor der satset på at få it integreret i alle fag....
17 børns syn på skolen i skoleåret 2016-2017
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Broström, Stig
, at pigerne er målrettede og opgaveorienterede, mens drengene er larmende og vil være hurtigt færdige. Men når de har givet det generaliserende svar, tager de sig selv i det og reflekterer over, at det faktisk kommer an på personen. De hæver sig altså op over det stereotype billede af drenge og piger«. »Jeg...... konflikter. Pigerne går mere i detaljer og diskuterer for eksempel farven på opgavens omslag. Det, synes drengene, er latterligt«. Det ligner, at de fleste elever giver udtryk for en meget traditionel opfattelse af, at drengene larmer, og pigerne arbejder hårdere? »Ja, det kan man godt sige. Men drengene er...... har brug for mere kropslig aktivitet. Det siger noget om, at reformen kalder på mere bevægelse. Men det er ikke rigtig lykkedes«. Hvad er status på reformen blandt eleverne? »Generelt er alle glade for at gå i skole. De synes, det er dejligt at lære noget. Men det bliver rigtig spændende at gå i skole...
Brugere på Den Danske Forenings lukkede Facebook-gruppe diskuterer væbnet kamp mod muslimer
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Eberholst, Mads Kæmsgaard
2015-01-01
Hvor alvorligt skal det tages? Det skal tages alvorligt, for den slags aktivitet er der ikke for sjov. Man skal være bevidst om, at nogle måske er villige til at handle, som vi ser det i Sverige. Heldigvis er det de færreste tosser, som reelt gør noget ved det....
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Gramtorp, Anne
2013-01-01
), (Stenholm, 2011), (Cardon et al, 2009). Majoriteten af entreprenørskabslitteraturen måler motivation som et skalaforhold, som noget der enten er der eller ikke er der og beskriver motivation synonymt med begreberne intention, ambition og villighed. Fælles for entreprenørskabsforskningens bearbejdning af...
Forandring af undervisningspraksis - hvordan bruger lærere IT i nærundervisningen?
Directory of Open Access Journals (Sweden)
Helle Bækkelund Jensen
2003-05-01
Full Text Available
Første gang publiceret i UNEV nr. 1: Undervisningsformer på nettet, november 2003, red. Simon Heilesen og Helle Bækkelund Jensen. ISSN 1603-5518.
Denne artikel søger at klarlægge, hvordan og ikke mindst hvorfor universitetsundervisere anvender IKT, og hvilke forandringer af deres pædagogiske praksis, de oplever. Bagved ligger en antagelse om, at undervisernes måde at anvende bestemte former for teknologi på samtidig siger noget om, hvordan de opfatter undervisningen og deres rolle i denne. Samtidig er det interessant at undersøge den aktuelle praksis, sådan som den beskrives og genfortælles af praktikerne (underviserne, for at lære noget om, hvordan teknologien er kommet ind i undervisningen og hvordan undervisning begribes – for i sidste ende at kunne sige noget om, hvordan man kan tilrettelægge IKT-pædagogisk kompetenceudvikling for universitetsundervisere. Artiklen handler om universiteternes dagstudier, hvor der er tale om netstøttet undervisning i den form, at web-steder bliver specielt oprettet og anvendt til undervisningen på universitetets on-campus uddannelser som en udbygning eller supplement til forelæsninger og kursusundervisning.
Loch Ness, Yeti og læringsstile
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Johansen, Martin Blok; Oksbjerg, Marianne
2013-01-01
Analyse og diskussion af læringsstilsbegrebet, som det fremstilles af Dunn og Dunn. I artiklen argumenteres der for, at der ikke er noget videnskabeligt belæg for at bringe læringsstile ind i klasseværelset. Det er alene en tros- og følelsessag....
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Trettvik, Johan
2013-01-01
Vores teoretiske forhold til virkeligheden er meget omdiskuteret, og særlig spørgsmålet om, hvorvidt vores viden afspejler noget virkeligt, er centralt i diskussionen af begrebet om virkelighed. I psykologien har det sat sine spor ved enten en reduktionistisk holdning til sit genstandsfelt eller ...
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Skajaa, Anders; Jørgensen, Jakob Heide
MATLAB er et matematik-program som fokuserer på anvendelsen af matricer og vektorer. Deraf navnet MATrix LABoratory. Denne bog er en praktisk vejledning i at forstår og anvende MATLAB syntaksen og fungerer som en hurtig genvej til dig, der skal i gang med at anvende MATLAB i forbindelse med fx dit...
Landbrugets strukturudvikling frem til 2030
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Hansen, Henning Otte
2014-01-01
Landbrugets strukturudvikling fremover har stor interesse, fordi den dels fortæller noget om den aktuelle udvikling, dels er grundlaget for en mulig styring eller påvirkning af udviklingen. Strukturudviklingen er dog i vid udstrækning upåvirket af de økonomiske og politiske rammevilkår - bl...
Kayhan, Hüseyin Cahit
2013-01-01
Bu çalışmada alan yazın taraması yapılarak Türkiye'de Matematik öğretiminde drama, dramatizasyon ve yaratıcı drama yönteminin yeri nedir?” sorusuna yanıt aranmıştır. İlgili literatür incelemesi doğrultusunda drama, dramatizasyon ve yaratıcı dramanın öğretim açısından önemi ve özellikle Türkiye'de matematik öğretiminde yaratıcı dramanın bir yöntem olarak kullanılması ile ilgili yapılmış araştırmalar değerlendirilmiştir. Matematik, soyut kavramların kazanılmasındaki zorluklardan dolayı öğrencil...
Kayhan, Hüseyin
2013-01-01
Bu çalışmada alan yazın taraması yapılarak Türkiye'de Matematik öğretiminde drama, dramatizasyon ve yaratıcı drama yönteminin yeri nedir?” sorusuna yanıt aranmıştır. İlgili literatür incelemesi doğrultusunda drama, dramatizasyon ve yaratıcı dramanın öğretim açısından önemi ve özellikle Türkiye'de matematik öğretiminde yaratıcı dramanın bir yöntem olarak kullanılması ile ilgili yapılmış araştırmalar değerlendirilmiştir. Matematik, soyut kavramların kazanılmasındaki zorluklardan dolay...
DEFF Research Database (Denmark)
Teknisk Ståbi er de bygningsprojekterendes og entreprenørers håndbog. Den dækker matematik, fysik, statestik, laster og sikkerhed samt beggematerialerne: beton, stål, træ, murværk, letbeton, glas og endelig fundering. Denne udgave er en næsten totalrevision, baseret på de nye Eurocodes, der afløs...
Directory of Open Access Journals (Sweden)
Sacide Güzin Mazman Akar
2017-04-01
Full Text Available The purpose of this study is to adapt “Student Engagement in Mathematics Scale”, developed by Rimm-Kauffman (2010, into Turkish and to determine validity and reliability of the scale in Turkish form. The study group is consisted of 602 secondary school students. The original scale consisted of 13 items with three factors (social, emotional and cognitive. Adapted scale’s test-retest reliability coefficient was found .591 and Cronbach alpha value was found .872. Item-total correlations of scale items ranged between .30 to .66. First order and second order confirmatory factor analyses were executed for construct validity. As a result of confirmatory factor analyses, the scale was confirmed consisting of three factors namely “social”, “cognitive” and “emotional” as in original scale. These results showed that Turkish form of the scale, being reliable and valid, can be used in studies related to mathematics engagement. [Bu araştırmanın amacı Rimm-Kauffman (2010 tarafından geliştirilen “Matematik Dersine Bağlılık Ölçeği”ni Türkçeye uyarlamak, geçerlik ve güvenirlik çalışma sonuçlarını ortaya koymaktır. Çalışma grubunu “Matematik Dersine Bağlılık Ölçeği’ni” yanıtlayan 602 ortaokul öğrencisi oluşturmaktadır. Orijinal ölçek 13 madde ve üç faktörden (sosyal, duyuşsal ve bilişsel oluşmaktadır. Ölçeğin test tekrar test güvenirlik katsayısı .591 hesaplanırken, iç tutarlılık katsayısı .872 olarak elde edilmiş ve maddelerin birbiri ile ilişkisini gösteren madde-toplam korelasyonlarının .30 ile .66 arasında değer aldığı saptanmıştır. Ölçeğin yapı geçerlik çalışmaları için birinci ve ikinci düzey doğrulayıcı faktör analizleri yapılmıştır. Yapılan doğrulayıcı faktör analizleri sonunda ölçeğin orijinal ölçekteki gibi “sosyal”, “bilişsel” ve “duyuşsal” bağlılık olmak üzere üç faktörden oluştuğu doğrulanmış ve
DEFF Research Database (Denmark)
Hermansen, Judy
2009-01-01
Den franske sociolog Pierre Bourdieu påstod, at smag er noget man tilegner sig gennem opdragelse og socialisering og derfor så dybt rodfæstet i personligheden, at den er meget vanskelig at ændre på. Denne opfattelse har været kritiseret af mange postmoderne trendforskere og symbolanalytikere, som...
DEFF Research Database (Denmark)
Nygaard, Bertel
Håbet er lysegrønt, siger vi. Men ifølge Bertel Nygaard, håbshistoriker ved Aarhus Universitet, er håbet spraglet og kulørt, det er historisk foranderligt, og vi håber alle på noget forskelligt: Lenin håbede på kommunismen, Martin Luther King på et USA fri for racisme, fangerne i nazisternes kz...
Når der ikke er noget tredje valg
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Rasch, Vibeke; Knudsen, Lisbeth B.; Gammeltoft, Tine
indvandrerkvinder og en gruppe kvinder med dansk baggrund, der fik foretaget abort i perioden september 2002 - april 2003. Denne del af undersøgelsen bidrager med information omkring selve beslutningsprocessen i forbindelse med valget af provokeret abort samt de mekanismer som har ført til graviditetens opståen og...
Dronningerunder og regeringsdannelser
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Knudsen, Tim; Adler-Nissen, Rebecca
2005-01-01
Er den såkaldte dronningerunde uden politisk betydning? Eller har den danske monark mulighed for at påvirke regeringsdannelsen? Noget tyder på, at der er behov for en præcisering af grundloven, hvis man ikke ønsker, at hoffet på ny kan blive beskyldt for at begå statskup...
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Weirsøe, Mathilde
2010-01-01
Unge indvandrerkvinder stormer ind på gymnasierne og derfra videre til universiteterne. De unge kvinder er ikke bare mønsterelever, men også mønsterbrydere. Hvorfor når de så langt? Er det i virkeligheden noget helt andet end forældrenes uddannelse, arbejde og indkomst, der har betydning for...
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Jeppesen, Jens Peder
2008-01-01
Vinterens bulefiskeri efter gydemodne torsk på Øresund, er om noget, en sag der skiller vandene blandt danske lystfiskere. Fiskeriet har såvel trofaste tilhængere som indædte modstandere, og man kan roligt sige, at der er tale om en varm kartoffel. Men hvad er myte og hvad er facts? Fisk & Fri ha...... snakket med folk, der har forskellige indgangsvinkler til bulefiskeri for at kaste lys over fænomenet. Udgivelsesdato: Dec./Jan....
Bir Ortaokul Matematik Öğretmeninin WebQuestin Uygulamasına Yönelik Görüşü
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Aytaç Kurtuluş
2014-03-01
Full Text Available t. Bu çalışmada bir WebQuest etkinliğini sınıfında ilk defa uygulayan bir ortaokul matematik öğretmeninin WebQuestin uygulama sürecine ve öğrencileri üzerinde bıraktığı etkisine yönelik görüşü incelenmiştir. Çalışmaya katılan öğretmen histogram konusuna yönelik hazırlamış olduğu bir WebQuest etkinliğini 8. sınıf öğrencilerine proje ödevi olarak uygulamıştır. Bu çalışma olgubilim araştırması olarak tasarlanmış olup, veriler öğretmenle uygulama sırasında ve sonunda yapılan görüşmelerden ve uygulama sonunda öğrencilerle yapılan görüşmeler ve öğrenci sunumlarının gözlemlenmesi yoluyla toplanmıştır. Çalışma bulguları, WebQuest uygulamasının öğrencilerin motivasyonuna, özgüvenlerine olumlu katkıda bulunduğunu göstermiştir. Elde edilen öğretmen görüşleri, WebQuestlerin proje ve performans ödevi olarak uygulanabileceğini ve ortaokul matematik öğretim programını desteklediğini ortaya koymuşt
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Krøgholt, Ida
2017-01-01
Sex er en del af vores sociale praksis og centralt for det, vi hver især er. Men bortset fra pornoindustrien, har vi ikke mange muligheder for at få adgang til billeder af sex. Teater Nordkrafts forestilling Sex in situ vil gøre seksuelle billeder til noget, der kan deles, udveksles og tales om, og...
Multiple perspectives on symptom interpretation in primary care research
DEFF Research Database (Denmark)
Rosendal, Marianne; Jarbøl, Dorte Ejg; Pedersen, Anette Fischer
2013-01-01
Vurdering af symptomer er en af de vigtigste opgaver i den primære sundhedssektor. Symptomer beskrives ofte som noget absolut, men hos både læge og patient er symptomer resultatet af en fortolkningsproces, som påvirkes af en række forhold. Denne artikel ser nærmere på, hvordan symptomer fortolkes...
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Stacey, Julia; Søndergaard, Helle Alsted
2003-01-01
Selv om børnefamilier i dag har travlt, prioriterer de at samles omkring middagsbordet hver aften, og de vil have sund og hjemmelavet mad. Men ét er idealet, noget andet er virkeligheden i en travl hverdag. Derfor ender de nemme og hurtige løsninger lidt for ofte på middagsbordet i mange børnefam...
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Hermansen, Judy
2008-01-01
Mange brandingbøger kommer med én bestemt opskrift på, hvad branding er for noget, og hvad det er for nogle strategier, man skal anlægge. Men der ligger altid mange antagelser bag de gode råd, som bare aldrig bliver sagt explicit. Hvilke antagelser bygger relationsteorien fx på? Eller Martin...
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Geertz, Armin W.; Bjerrisgaard, Line Tviis
2007-01-01
At religion kan være sundhedsskadeligt er velkendt. Men at bøn også kan være det, er noget nyt. Herbert Benson, læge ved Harvard Universitet, har foretaget en storstilet videnskabelig undersøgelse af fjernforbøn på seks forskellige amerikanske sygehuse. Undersøgelsen viser - stik imod Bensons per...
Directory of Open Access Journals (Sweden)
Frasticha Frasticha
2016-08-01
Full Text Available Pemecahan masalah merupakan kegiatan matematika yang sulit baik dalam mempelajari maupun mengajarkannya, sehingga diperlukan adanya suatu model pembelajaran yang dapat memberikan pengaruh positif terhadap kemampuan pemecahan masalah siswa. Salah satu model pembelajaran yang dapat digunakan yaitu model pembelajaran ARIAS dengan strategi active learning tipe ICM. Penelitian ini bertujuan untuk mengetahui: (1 model pembelajaran ARIAS dengan strategi active learning tipe ICM berpengaruh terhadap kemampuan pemecahan masalah matematik siswa SMA; (2 Sikap siswa terhadap pembelajaran matematika menggunakan model pembelajaran ARIAS dengan strategi active learning tipe ICM. Subjek penelitian ini adalah siswa kelas XI IPA 1 dengan jumlah 38 siswa sebagai kelas kontrol dan XI IPA 2 dengan jumlah 39 siswa sebagai kelas eksperimen di SMAN 19 Kabupaten Tangerang pada tahun ajaran 2015-2016. Metode penelitian yang digunakan adalah metode penelitian eksperimen dengan adalah desain kuasi eksperimen dengan bentuk Nonequivalent Control Group serta Cluster Sampling sebagai teknik pengambilan sampel. Analisis data dalam penelitian ini menggunakan SPSS Statistics Version 22. Hasil penelitian :(1 model pembelajaran ARIAS dengan strategi active learning tipe ICM berpengaruh terhadap kemampuan pemecahan masalah matematik siswa SMA dan memberikan pengaruh yang positif; (2 sikap siswa positif terhadap model pembelajaran ARIAS dengan strategi active learning tipe ICM. Kata Kunci: Assurance Relevance Interest Assessment Satisfaction, Index Card Match, Kemampuan Pemecahan Masalah
Ortaöğretim dokuzuncu sınıf matematik ders kitabına ilişkin öğretmen ve öğrenci görüşleri
Karaca Gün, Canan
2009-01-01
Bu araştırmanın amacı, ortaöğretim okullarının 9. sınıflarında okutulan matematik ders kitabına ilişkin öğretmen ve öğrenci görüşlerini belirlemektir. Araştırmanın çalışma evrenini, Aydın il merkezindeki toplam 19 ortaöğretim okulunda görev yapan matematik öğretmenleri ve bu okullarda öğrenim gören 9. sınıf öğrencileri oluşturmaktadır. Araştırmada nicel araştırma ve nitel araştırma yöntemleri birlikte kullanılarak, sayısal veriler sözel veriler ile desteklenmiştir. Örneklem seçimi iki farklı ...
DEFF Research Database (Denmark)
Elling, Rasmus Christian
2016-01-01
Gang på gang har Iran som stat og folk fremkaldt misforståelser, fascination og fordømmelser. Kritikere forkaster landets religiøse ledere og politiske undertrykkelse; kendere lovpriser landets dybe kulturhistorie og mangfoldighed. Men hvorfor er særligt Iran genstand for så blandede opfattelser......? Er Iran noget helt særligt – eller ganske almindelig?...
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Jensen, Henrik
2008-01-01
Flash er et programmeringssprog og kan som sådant ikke noget i sig selv. Kursets mål er, at give den studerende et grundlæggende kendskab til Flash, så det kan bruges til præsentationer på skærm og til produktion af hjemmesider. På kurset arbejdes der med billede, grafik, lyd, video og interakti...
There is Nothing more Toxic than a Human Child
DEFF Research Database (Denmark)
Rösing, Lilian Munk
2012-01-01
En analyse af Pixar Studios animationsfilm, Monsters Inc, som handler om et samfund af monstre, der får sin energiforsyning fra skræmte børn. Hvad nu, hvis det ikke er monstrene, der har brug for børnenes energi, men børnenes energi, der har brug for monstre? Og hvad nu, hvis der er noget sandt i...
DEFF Research Database (Denmark)
Feldt, Jakob Egholm
2013-01-01
Siden 11. september 2001 og efter Muhammed-krisen er ’islamkritik’ gradvist blevet et accepteret begreb, som betegner kritik af islam som religion, filosofi, politik og livsform. Det er samtidig blevet en levevej for folk, som i islam ser en fascisme, der truer demokratiet, friheden og nationen...
Barrierer i landskabet - betyder de noget for de vilde dyr?
DEFF Research Database (Denmark)
Madsen, A. B.; Simonsen, V.; Pertoldi, C.
Mennesket har igennem mange århundreder ændret det danske landskab. Dette fremstår i dag som et mosaikagtigt kulturlandskab bestående af mange forskellige fragmenter af oprindelig natur omgivet af opdyrket land. De mest synlige menneskeskabte barrierer i landskabet er veje og jernbaner, som kan...... være mere eller mindre effektive hindringer for spredning af plante- og dyrepopulationer. Andre barrierer som vandløb og søer samt hav- og fjordområder er i stor udstrækning skabt af naturen selv. De zoologiske museers indsamling og dokumentation i det 19. og 20. århundrede viser sig nu at være af...... af barriererne i landskabet er de trafikdræbte dyr på vejene. Indsamler man data over antallet og fordelingen af trafikdræbte dyr, fås også et tydeligt billede af de barrierer i landskabet som vejene giver anledning til. Sandsynligheden for at små dyr bliver dræbt i trafikken kan beskrives i simple...
Rend og Hop på Jellingmonumenterne
DEFF Research Database (Denmark)
Christensen, Mette Nørregaard; Larsen, Lars Kjær
Bogen indeholder en række forslag til matematik- og historielege tilpasset pædagogers arbejde og Monumentområdet ved Nationalmuseet Kongernes Jelling. Legene er blevet til i et samarbejde mellem Pædagogstuderende UCL, Nationalmuseet Kongernes Jelling og HistorieLab-Nationalt videncenter for Histo...
I fremtiden kan lugt måske lokke køerne til kælvningsboksen i tide
DEFF Research Database (Denmark)
Rørvang, Maria Vilain; Sørensen, Linda Søndergaard
2017-01-01
Noget tyder på, at koen i de sidste timer før kælvning er tiltrukket til stedet, hvor andre køer for nylig har kælvet – muligvis pga. lugten af fostervæske. Det viser et pilotforsøg ved Institut for Husdyrvidenskab, Aarhus Universitet. Dette åbner op for nye muligheder, hvis koens valg af kælvnin...
DEFF Research Database (Denmark)
Pedersen, Nils Arne
2011-01-01
En moderne forskningstradition hævder, at der oprindeligt ikke var noget forbud mod selvmord inden for kristendommen, og at selvmord ikke blev skelnet fra offerdød og martyrdød. Artiklen søger at vise, at dette er forkert...
DEFF Research Database (Denmark)
Schepelern, Peter
2010-01-01
Efter en historisk oversigt over samspillet mellem film og litteratur i dansk film, opstilles en råkke begreber, som filmatiseringer kan analyseres ud fra. Der ses pa det litteråre vårks status — evt. som klassiker eller bestseller. Der ses pa de centrale filmatiseringsproblemer, forhold som pråger...... adaptionsprocessen fra bog til film. De kan opdeles dels i forhold, der udspringer af filmsprogets specifikke sys- tem, dels forhold, der udspringer af filmens status som massemedium. Den färste kategori er pråget af, at filmsproget generelt fremstiller handling snarere end refleksion, noget konkret snarere end...... noget abstrakt, en scene snarere end et resume og det ydre snarere det indre. Den anden kategori kan forklare filmens tilbäjelighed til åndring af forlågget, til forkortelse, forenkling og modernisering. Eksemplerne er en råkke centrale danske film/romaner...
Grådigheden efter konstant at være på
DEFF Research Database (Denmark)
Holdt Christensen, Peter
2014-01-01
Nærvær. Selv om vi ikke altid tænker over det, er vores konstante digitale tilstedeværelse derfor ikke kun noget der viser, at jeg er digital tilgængelig, til rådighed og fuldstændig opdateret om, hvad der sker i verden. Den risikerer også at gøre det surt for andre. Selv om det sociale fællesska...
DEFF Research Database (Denmark)
Sandøe, Peter
2014-01-01
Fødevareminister Dan Jørgensen vil gøre noget ved forholdene i svineproduktionen. Siden sidste sommer har der dog ligget en rapport på ministerens bord, som viser, at pattegrisedødeligheden er på vej ned. Mon han har læst den?...
”Er jeg akademiker nok?” – masseuniversitetets studenterkampe om legitim uddannelseskultur
Directory of Open Access Journals (Sweden)
Karin Højbjerg
2015-03-01
Full Text Available Siden anden verdenskrig er antallet af studerende på videregående uddannelser øget dramatisk. Som noget nyt har også professionsbachelorer adgang til visse af univer¬si-teternes kandidatuddannelser. Dette gælder således for kandidatuddannelsen i Læring og Forandringsprocesser på Aalborg Universitet, hvor denne artikels empiri er genereret fra. Artiklen fremlægger resultaterne af en undersøgelse af, hvordan studerende med forskellige uddannelsesbaggrunde må kæmpe om at definere sig selv og medstuderende som akademikere. Artiklens hovedbegreber er taget fra Pierre Bourdieus praktikteori (Bourdieu, 1996; 1997. Det empiriske materiale består af interviews med otte studerende fra samme årgang på kandidatuddannelsen i Læring og Forandringsprocesser. Materialet er bearbejdet ud fra et Bourdieuinspireret, relationelt blik og er kondenseret ned til fremtrædende træk ved forskelligartede strategier. Artiklen viser eksempler på fire studiestrategier, der relaterer sig til, hvordan man som studerende forholder sig til det at arbejde ”akademisk”: En oprørsstrategi der går mod forestillingen om den dominerende universitetskultur ; en strategi der i udgangspunktet ønsker at inkludere og anerkende andre strategier, men med en oplevelse af at motivationen gradvist forsvinder ; en strategi hvor den studerende aktivt afviser og undgår samarbejde med studerende med bestemte uddannel¬ses¬baggrunde, og endelig en kulturelt opadgående strategi der gradvis er lykkedes med at aflæse den ”akademiske kode". The number of students entering higher education since the Second World War has grown dramatically. As a consequence, students from University Colleges are now given admittance to certain master programmes at the established universities. This article presents the results of a study of how students with different educational backgrounds struggle to define themselves and their fellow students as academics. In this study we focus on
4 trin til succesfuld samskabelse
DEFF Research Database (Denmark)
Hald Larsen, Stine
2014-01-01
Samskabelsesprojekter mellem offentlige, frivillige og private organisationer er en vigtig kilde til innovation. Som leder af samskabelse skal du tage initiativ til og facilitere forhandlingsprocesser, så alle parter får noget ud af samarbejdet. Læs her, hvordan du leder en forhandlingsproces i f...
Analyzing Mathematics Teachers? Classroom Communication
DEFF Research Database (Denmark)
Ejersbo, Lisser Rye
2004-01-01
In: Matematik og Sprog, edited by Svensk forening for matematikdidaktisk forskning. MADIF4, Malmö Högskola. 2004 Kort beskrivelse Man kan ikke overvurdere vigtigheden af formidling af matematisk læring og tænkning. Når matematiklæreren arbejder med problemløsning i matematiktimen, så er det vigti...
Tværprofessionelt samarbejde i børnehøjde
DEFF Research Database (Denmark)
Villumsen, Anne Marie Anker
2017-01-01
daginstitutioner er arbejdet med opsporing af udsathed hos børn indgangen til det tværprofessionelle samarbejde. Typen og graden af udsathed afgør, hvorvidt det er noget, man selv kan løse inden for daginstitutionens rammer, eller om der skal kaldes på andre professioner uden for institutionen – og hvis dette er...... statisk definition. Baseret på 14 empiriske cases fra daginstitutioner, viser kapitlet centrale potentialer ved at arbejde mere systematisk med opsporing og analyse af udsathed – og betydningen af dette for initieringen af det tværprofessionelle samarbejde....
En alternativ sundhedsstrategi
DEFF Research Database (Denmark)
Andersen, Heidi Lene
2016-01-01
Hvis vi som samfund ønsker at ændre på den nuværende situation med ulighed i sundhed, må vi gøre noget anderledes og lede efter supplementer og alternativer til de nuværende sundhedsstrategier. En community health-tilgang er ét alternativ...
Livets febrile hemmeligheder. Et litterært slægtskab mellem Henrik Pontoppidan og Thomas Mann
DEFF Research Database (Denmark)
Vangshardt, Rasmus
filosofferne Arthur Schopenhauer og Friedrich Nietzsche – og med Thomas Mann. Det giver samtidig anledning til en revurdering af De Dødes Riges slutning: Siden bogens udgivelse har litterater diskuteret, hvorvidt dens slut-utopi er beundringsværdig eller tynd. Men Livets febrile hemmeligheder påpeger noget...
DEFF Research Database (Denmark)
Lund, Anker Brink
2018-01-01
dokumenteres en gradvis udvikling fra relativt ensartet og synkroniseret dækning via øget målgruppesegmentering til noget, der bedst kan sammenfattes som polariseret centrifugering af dansk politik. Det er stadigvæk "gammeldags" dagsbladsredaktioner plus traditionsrige radio- og TV-stationer, der står for de...
DEFF Research Database (Denmark)
Ravn, Ib
2012-01-01
På universitetet trænes de studerende i at tage ting fra hinanden: analysere, problematisere og kritisere. Intellektuelt og videnskabeligt er det selvsagt uvurderlige evner, men på en arbejdsplads skal man bygge noget op, der fungerer. Det handler oftere om at syntetisere, dvs. om at skabe nye...
DEFF Research Database (Denmark)
Sandøe, Peter
2015-01-01
Ingen gør med vilje noget moralsk forkert, mente Sokrates, men i praksis har vi mennesker det med at tilpasse holdning til handling. For eksempel går folk mindre op i køers ve og vel, når de lige har spist beef jerky....
DEFF Research Database (Denmark)
Kvistgaard, Peter; Hird, John
2006-01-01
Oplevelsesøkonomi i en turismekontekst handler om den gode handel; om overskud på hver enkelt turists personlige oplevelsesregnskab. Hvordan den enkelte definerer oplevelser, er naturligvis no-get personligt. Her påpeger kritiske røster, at end ikke Legoland tilbyder skræddersyede oplevelser. Nej...
DEFF Research Database (Denmark)
Larsson, Flemming
2005-01-01
Innovation indgår som et centralt tema i mange virksomheders vision og mission statements. Det giver god mening, da innovation er bredt anerkendt som noget positivt, der skaber værdi for kunden, og samtidigt giver virksomheden konkurrencemæssig fordel. Men paradoksalt nok, så afspejler...
Etisk Råd: GMO kan bidrage med noget væsentligt
DEFF Research Database (Denmark)
Gjerris, Mickey; Birkler, Jacob
2014-01-01
Forslaget om at lade EU's medlemslande sætte kriterier for at godkende GMO'er til dyrkning rummer en mulighed for at løfte debatten ud over den ufrugtbare skin-diskussion om risiko.......Forslaget om at lade EU's medlemslande sætte kriterier for at godkende GMO'er til dyrkning rummer en mulighed for at løfte debatten ud over den ufrugtbare skin-diskussion om risiko....
Liselerde Okutulmakta Olan Lise I. Sınıf Matematik Kitaplarının Değerlendirilmesi
ŞAHIN, Sevgi; TURANLI, Necla
2014-01-01
Bu çalışma lise I. sınıflardaki matematik derslerinde okutulan ders kitaplarının ve yardımcı kitapların öğrenmeyi sağlamadaki ve ÖSS\\'ye katkıları yönünden öğretmen ve öğrenci görüşlerini belirlemek amacıyla hazırlanmıştır. İstanbul ili dahilinde, Çağaloğlu Anadolu Lisesi, Bahçelievler Anadolu Lisesi, Adnan Menderes Anadolu Lisesi, Özel Safiye Sultan Kız Lisesi, Ataköy Cumhuriyet Lisesi, Pertevniyal Anadolu Lisesi, Özel Arel Koleji, Ataköy Lisesi ve Bahçelievler Lisesi\\'nde görev y...
Et deltagelsesperspektiv på lektionsstudier som metode til lærerudvikling i danmark
DEFF Research Database (Denmark)
Skott, Charlotte Krog; Møller, Hanne
2016-01-01
I kapitlet beskrives lektionsstudier (LS) med udgangspunkt i et forløb gennemført i tæt samarbejde mellem lærerteams i dansk og matematik på en skole i Københavns omegn og ressourcepersoner fra University College Capital (UCC). Fokus er på, hvordan dette samarbejde konstituerer sig i LS-forløbet,...
Mindsetbaseret undervisning – fra præstationskultur til læringskultur
DEFF Research Database (Denmark)
Nielsen, Jeppe; Kortnum, Allan; Videsen, Peter
Mindsetbaseret undervisning udfordrer udsagn som ”matematik er bare ikke mig” og gør op med myten om det naturlige talent. Måden, man tænker om sig selv og sine evner på, har betydning for, hvor godt man klarer sig i sin uddannelse, på arbejdspladsen, i sport og i familielivet. Mindsetteori bygge...
NIR: optimerer produktionen af gammeldags modnede sild
DEFF Research Database (Denmark)
Svensson, T.; Bro, Rasmus; Nielsen, Henrik Hauch
2005-01-01
Måling med nærinfrarødt (NIR) lys er et godt supplement til de nuværende metoder til at følge modningen af sild saltede i tønder. Det viser resultaterne af et forskningsprojekt udført i samarbejde mellem Lykkeberg A/S, Danmarks Fiskeriundersøgelser og Den Kgl Veterinær- og Landbohøjskole. Ved hjælp...... af avanceret matematik er det nemt og hurtigt at bestemme modningsgraden af sild direkte fra en NIR måling....
Er innovation og entreprenørskab overhovedet noget for skolen?
DEFF Research Database (Denmark)
Pedersen, Lene Tanggaard; Johannesen, Rikke
2012-01-01
Denne artikel har som sin bestræbelse helt kort at opridse mulige forskelle og ligheder mellem aktuelt populære begreber som kreativitet, innovation, iværksætteri, entreprenørskab og foretagsomhed. Søsterbegreber, der har mange overlap og sammenfald. Dertil vil vi kort opridse skoleledelsens mulige...
Lidelse og omsorg i organisationens skygge
DEFF Research Database (Denmark)
Poder, Poul
2013-01-01
Hvordan lidelse sættes i skyggen under organisationsforandring Teologer, filosoffer, læger og terapeuter taler om lidelse, men ikke organisationsforskere. Er det fordi lidelse forstået som det at blive overmandet af noget, der gør en passiv - ikke en del af arbejdslivet? Næppe. Artiklen undersøge...
Man kan ikke dumpe til folkeskolens afgangsprøve – eller kan man?
DEFF Research Database (Denmark)
Ejersbo, Lisser Rye
2016-01-01
Indførelse af karakterkravet 2 som adgangsgivende til de erhversfaglige uddannelser har forvandlet 9. klasses prøven i dansk og matematik til en ”high-stakes-eksamen”, altså en vind-eller-forsvind-prøve. Hvad betyder det for de elever, der ligger på grænsen? Og hvor ”sikker” er en sådan sortering...
Arbejdshukommelse og matematiklæring
DEFF Research Database (Denmark)
Ejersbo, Lisser Rye
2013-01-01
matematik, men også inden for andre områder som musik og kunst. Arbejdshukommelsen hviler på fundamentale kognitive færdigheder, som det er nødvendigt at udvikle for at kunne fungere i mange forskellige sammenhænge, herunder specielt de læringsmæssige. I dette kapitel vil jeg gøre rede for forskellige...
Bir Ortaokul Matematik Öğretmeninin WebQuestin Uygulamasına Yönelik Görüşü
Kurtuluş, Aytaç; Ada, Tuba; Yanık, H. Bahadır
2014-01-01
t. Bu çalışmada bir WebQuest etkinliğini sınıfında ilk defa uygulayan bir ortaokul matematik öğretmeninin WebQuestin uygulama sürecine ve öğrencileri üzerinde bıraktığı etkisine yönelik görüşü incelenmiştir. Çalışmaya katılan öğretmen histogram konusuna yönelik hazırlamış olduğu bir WebQuest etkinliğini 8. sınıf öğrencilerine proje ödevi olarak uygulamıştır. Bu çalışma olgubilim araştırması olarak tasarlanmış olup, veriler öğretmenle uygulama sırasında ve sonunda yapılan görüşm...
DEFF Research Database (Denmark)
Andersen, Johannes
2014-01-01
efter en 10+10+10 timers model. Ifølge lektor og samfundsforsker Johannes Andersen ved Institut for statskundskab på Aalborg Universitet, er antallet af stress ramte danskere steget fra 5 procent i 1989 til mere end 12 procent i 2010. Således tyder noget på, at danskerne ikke får den fornødne hvile....
Samfundsmæssige skævheder i klassen
DEFF Research Database (Denmark)
Brinkkjær, Ulf
2014-01-01
Sociale forskelle og dermed forskelle i både børns og læreres baggrundsmiljøer betyder noget for skolens distribution af viden og dermed for, hvad som læres af hvem og på hvilke måder. Denne indirekte form for ledelse i klasserummet kanaliserer skolesucces for det bedre stillede mellemlag. Kapitl...
Biogas og andet godt i søsalat
DEFF Research Database (Denmark)
Bangsø Nielsen, Henrik
2009-01-01
Søsalat indeholder ikke noget stort gaspotentiale, men til gengæld er der en række værdifulde stoffer i algerne, som vil kunne udnyttes af fødevare- og medicinalindustrien. Økonomisk set vil det således være mest oplagt at kombinere energiproduktionen med en produktion af højværdiprodukter....
Forskningsbibliotekerne får travlt, hvis den nationale Open Access strategi skal lykkes
DEFF Research Database (Denmark)
Ibanez, Karen Sofie Hytteballe; Sandfær, Anne
2014-01-01
Med nedsættelsen af en national styregruppe for Open Access (OA) ser der endelig ud til at ske noget på den front i Danmark. Uddannelses og Forskningsministeriet har, efter at have anbefalinger liggende i skuffen i flere år, nu endelig meldt en national strategi ud. Målet er 80% grøn OA i 2017 og...
DEFF Research Database (Denmark)
Uggerhøj, Lars; Nissen, Maria Appel; Pringle, Keith
2007-01-01
en forståelse af, hvordan hjælp bliver mulig. Et vigtigt tema er forestillingen om enpowerment og magt som noget konstruktivt. Forfatterne anlægger dermed en lidt anden, og mere optimistisk, synsvinkel på det sociale arbejdes muligheder, end det ofte har været tilfældet i de senere års toneangivende...
Nye didaktiske veje med mobile medier i voksenundervisningen af ordblinde
DEFF Research Database (Denmark)
Gjedde, Lisa; Misfeldt, Morten; Levinsen, Karin
2012-01-01
afprøvet mobiltelefonen som læringsværktøj i dansk og matematik. I projekter om læring på arbejdspladsen har mobillæring tidligere vist sig at have potentiale for ordblinde og læsesvage. (Gjedde & Gredsted 2005, 2007). Der er bl.a. høstet erfaringer med mobil tale-til-tekst, der først blev udviklet i MELFO...
Akutsygeplejen i spændingsfeltet mellem læring og organisationsforandring.
Pallesen, Stine Lovise; Stangerup, Pia
2016-01-01
Formålet med denne opgave er, at kigge på om organisationsforandringer i sundhedssektoren, har betydning for læring og den gode sygepleje i akutafdelingerne.Der har de sidste 10 år været stor udvikling og effektivisering af sundhedsvæsenet, og seneste tiltag i 2015 på akutafdelingerne i Region Sjælland, er et samarbejde med Beth Israel Medical Hospital i Boston, hvor akutsygeplejerskerne i akutafdelingerne i Region Sjælland, skal certificeres som noget helt nyt. Denne opgave bygger på fokusgr...
Diskussionen af Nykredits børsnotering i Finans/Invest samt forslag til en aktionærforeningsmodel
DEFF Research Database (Denmark)
Raaballe, Johannes
Møller og Nielsen (2016) argumenterer for, at Nykredit Holding efter en børsnotering er ”tvunget” til at maksimere markedsværdien af aktierne, og at dette indebærer, at Nykredits realkreditlåntagere og Foreningen Nykredit ikke får noget ud af ”kundekronemodellen”. Christensen og Rangvid (2016) ar....... Nærværende artikel er tænkt som et debatoplæg og rejser spørgsmålet, om man helt skal kaste en flere hundrede år gammel realkreditmodel på møddingen....
Da flashmobs blev kommercielle
DEFF Research Database (Denmark)
Thomsen, Line Hassall
2017-01-01
Det ligner leg. Og så leger du selv med. Men i virkeligheden er du pludselig en del af en markedsføring med sløret afsender. Det hele tager kun et par minutter i virkeligheden, og det synes måske ikke af noget stort, men det efterlader et medieprodukt, der varer langt længere og deles til hele ve...
DEFF Research Database (Denmark)
Lund, Henriette
2008-01-01
Begejstringen er bestemt til at få øje på, når Lisbet Kjærgaard, souschef på Skolen på Duevej, taler om Tidlig literacy − tidlig numeracy-projektet. Som ledelsesansvarlig for indskolingen har hun sammen med SFO-lederen det seneste år været dybt involveret i projektet. Noget der både har medført...
DEFF Research Database (Denmark)
Gehl, Jan
2001-01-01
Hvordan kan vi lide at bo? Nogle byer har en næsten magisk tiltrækningskraft på mennesker. Andre steder bryder vi os af uforklarlige grunde ikke om at være. Det handler ikke kun om, at noget er smukt eller grimt, men i høj grad om byrummet passer til vores sanser og krop. TV-udsendelse produceret...
DEFF Research Database (Denmark)
Rösing, Lilian Munk
2017-01-01
Kunstværker repræsenterer ikke, de inkarnerer. Det gjorde også de hysteriske kroppe som fødte psykoanalysen: de inkarnerede i kød og blod, hvad de ikke kunne repræsentere med konventionelle tegn. Kunstværkets betydning er ikke bare noget fraværende, som det refererer til, men nærværende i selve d...
Oplevelser. Koblinger og transformationer
DEFF Research Database (Denmark)
Jantzen, Christian; Jensen, Jens Frederik
Oplevelser er mellemledet mellem sansning of erfaring. Når vi oplever noget, knyttes der indsigt, mening og formål på vores indtryk. Oplevelser får os til at erkende vores omverden og os selv på nye spændende måder. Oplevelsesøkonomi drejer sig i den sammenhæng om nye kreative tilgange til produk...
DEFF Research Database (Denmark)
Falkenberg, Helene; Juelskjær, Malou
2015-01-01
læringsledelsen spatialiseres i en specifik udgave – den parkouriseres. Med parkouriseringen ’hacker’ læringsledelsen sig ind på et fænomen (parkour), som ikke har noget med skole at gøre. Denne indirekte form at fremme læring på, er et sindebillede på en ledelsestendens – også i en reformtid, og derfor en...
DEFF Research Database (Denmark)
Artiklerne i denne antologi er blevet til på baggrund af masterprojekter udarbejdet i forbindelse med afslutning af Masteruddannelsen i Ikt og læring (MIL). Ideen til antologien kom fra alumner, som fandt det relevant at sætte fokus på den iderigdom, kreativitet og nye viden, der skabes i...... af diverse typer af ikt viser bredden inden for dette spændende felt, som er i konstant udvikling. Antologien henvender sig derfor også bredt til alle, som interesserer sig for ikt og læring, hvad enten der er tale om teoretikere, praktikere, undervisere, studerende, arbejdsgivere og ansatte......, for hvem reflekteret brug af ikt er en del af den daglige praksis i et samfund, hvor livslang læring om noget er på dagsordenen....
Directory of Open Access Journals (Sweden)
Martin Bernard
2015-07-01
Full Text Available ABSTRAK Penelitian ini bertujuan untuk menelaah pencapaian dan peningkatan kemampuan komunikasi dan penalaran matematik siswa yang pembelajaran dengan pendekatan kontekstual melalui game Adobe Flash CS 4.0 lebih baik daripada pembelajaran kontekstual dengan cara biasa, menalaah asosiasi kemampuan komunikasi dan penalaran matematika siswa, asosiasi skala disposisi dan kemampuan komunikasi dan asosiasi skala disposisi dan kemampuan penalaran. Serta bagaimana menelaah kemampuan komunikasi dan penalaran matematik siswa terhadap pendekatan pembelajaran. Metode penelitian yang dipakai adalah menggunakan kuasi eksperimen. Dimana metode ini terdiri dua kelas, bahwa kelas pertama diberi perlakuan yaitu kelas yang pembelajaran pendekatan kontekstual menggunakan game Adobe Flash CS 4.0 dan kelas yang kedua yaitu kelas yang pembelajaran pendekatan kontekstual dengan cara biasa. Populasi yang diambil di sekolah SMK Mahardika dan sampelnya adalah 40 siswa kelas X.1 sebagai kelas Kontrol dan 42 siswa kelas X.2 sebagai kelas Eksperimen. Instrumen yang digunakan berupa 10 butir soal diantaranya 5 soal kemampuan komunikasi dan 5 soal kemampuan penalaran berbentuk uraian yang telah diuji validitas, realibilitas, derajat pembeda dan indeks kesukaran. Untuk angket skala disposisi yang digunakan adalah angket skala Linkert yang berbentuk ordinal yang akan dikonversi ke bentuk interval melalui Method Seccessive Interval (MSI. Kesimpulan dari penelitian tersebut yaitu pencapaian dan peningkatan kemampuan komunikasi dan penalaran serta disposisi matematik siswa dengan pendekatan kontekstual melalui Game Adobe Flash CS 4.0 lebih baik dibandingkan dengan pembelajaran cara biasa, adanya asosiasi antara kemampuan komunikasi dan penalaran tetapi tidak ada asosiasi antara disposisi dengan kemampuan komunikasi dan penalaran. Kata Kunci : Komunikasi, Penalaran, Skala Disposisi, Pendekatan Kontekstual, Adobe Flash CS 4 ABSTRACT This study aimed to examine the
Matematik Öğretmenlerinin 5E Öğretim Modeline Yönelik Görüşleri
Biber, A. Çağrı; Tuna, Abdulkadir
2015-01-01
Bu araştırmanın amacı matematik öğretmenlerinin 5E modeli hakkındaki görüşlerini incelemektir. Araştırmada betimsel yöntem kullanılmıştır. Betimsel yöntem, geçmişte ya da halen var olan bir durumu var olduğu sekliyle betimlemeyi amaçlayan araştırma yaklaşımıdır. Veri toplama aracı olarak yarı yapılandırılmış görüşme ve yarı-yapılandırılmış gözlem teknikleri kullanılmıştır.Çalışmanın örneklemini 2013- 2014 eğitim öğretim yılında Kastamonu ili merkezinde çeşitli ilköğretim okullarında görev yap...
Rab7a modulates ER stress and ER morphology.
Mateus, Duarte; Marini, Elettra Sara; Progida, Cinzia; Bakke, Oddmund
2018-05-01
The Endoplasmic Reticulum (ER) is a membranous organelle with diverse structural and functional domains. Peripheral ER includes interconnected tubules, and dense tubular arrays called "ER matrices" together with bona fide flat cisternae. Transitions between these states are regulated by membrane-associated proteins and cytosolic factors. Recently, the small GTPases Rab10 and Rab18 were reported to control ER shape by regulating ER dynamics and fusion. Here, we present evidence that another Rab protein, Rab7a, modulates the ER morphology by controlling the ER homeostasis and ER stress. Indeed, inhibition of Rab7a expression by siRNA or expression of the dominant negative mutant Rab7aT22 N, leads to enlargement of sheet-like ER structures and spreading towards the cell periphery. Notably, such alterations are ascribable neither to a direct modulation of the ER shaping proteins Reticulon-4b and CLIMP63, nor to interactions with Protrudin, a Rab7a-binding protein known to affect the ER organization. Conversely, depletion of Rab7a leads to basal ER stress, in turn causing ER membrane expansion. Both ER enlargement and basal ER stress are reverted in rescue experiments by Rab7a re-expression, as well as by the ER chemical chaperone tauroursodeoxycholic acid (TUDCA). Collectively, these findings reveal a new role of Rab7a in ER homeostasis, and indicate that genetic and pharmacological ER stress manipulation may restore ER morphology in Rab7a silenced cells. Copyright © 2018 Elsevier B.V. All rights reserved.
Modernitet og forbrugskultur i Chile
DEFF Research Database (Denmark)
Cristoffanini, Pablo Rolando
2012-01-01
I de sidste årtier er Chile blevet et egentligt forbrugersamfund. Udbredelsen af forbrugskulturen og forbrugerismen er centrale fænomener i chilenernes dagligliv og har nået et omfang, som har konsekvenser for de borgere, der ikke kan deltage fuldt ud heri, noget som er typisk for et samfund med en...... ujævn økonomisk udvikling og med store sociale forskelle. Denne proces er ikke et produkt af en stille, fredelig og naturlig samfundsudvikling, således som magteliten og de toneangivende intellektuelle i Chile har fremstillet det. Som jeg vil vise, er skabelsen af et egentlig forbrugssamfund knyttet til...... til i dag. Ifølge disse er Chile blevet et moderne samfund netop i kraft af, at Chile er et ægte forbrugersamfund med alt, hvad dette indebærer, såvel materielt som symbolsk. For det tredje er billedet af Chile som en ”supermoderne” nation i den latinamerikanske kontekst en udbredt forestilling hos...
BIM og parametrisk formgivning
DEFF Research Database (Denmark)
Hermund, Anders
2009-01-01
Digitale værktøjer i byggebranchen er i og for sig ikke noget nyt. I hvert fald ikke splinternyt. Siden 1980’erne har en gradvis digitalisering slået rødder på en måde der ikke lader megen tvivl tilbage om hvorvidt det fremtidige byggeri kommer til at foregå med eller uden computerens hjælp. Tekn...
strong>Hvad skal vi med en hjerne?strong>
DEFF Research Database (Denmark)
Hermansen, Judy
2009-01-01
neurologen Antonio Damasio, at sikre vores overlevelse og velbefindende (i nævnte rækkefølge). Vi ved, at der findes såkaldte belønningsstrukturer i hjernen på både dyr og mennesker, som aktiverer følelser af velbehag, når vi gør "det rigtige", dvs. noget der er godt for os. Men hvordan de mere konkret...
Hjem, stue, butik, museum - og Ikea
DEFF Research Database (Denmark)
Ingemann, Bruno
2009-01-01
den præsenteres i Ikeas udstilling i juni 2007. Med henblik på at konstruere forskellige blikke på disse stuer anvendes fotografi et som et analytisk værktøj, der ikke i sig selv er analysens mål, men som bruges til at udfordre og undersøge de fysiske rum for at kunne sige noget om det visuelle liv...
Vikingeborgen i Limfjordslandet
DEFF Research Database (Denmark)
Sindbæk, Søren Michael
2013-01-01
. Arkæologien har vist, at borgene blev bygget omkring eller kort før år 980, mens Harald Blåtand var konge, og så godt som sikkert på hans befaling. Hverken før eller siden fik folk i vikingetidens Danmark noget lignende at se. Hvordan blev et byggeri som dette muligt? For nylig er det lykkedes at kaste nyt...
DEFF Research Database (Denmark)
Danbolt, Mathias
2017-01-01
I de seneste par år har der været heftige diskussioner i danske medier om brugen af raciale stereotyper på indpakningen af såkaldte kolonialvarer i supermarkederne. Kritikken af billedernes racistiske effekter er ofte blevet afvist med påstanden om, at det er absurd at tale om racisme i mødet med...... noget så hverdagsagtigt som emballagen på kaffe, kakao eller chokolade. Men kikker man den danske mærkevarehistorie i kortene, står det klart at reklamebilleders påvirkningskraft ikke er til at spøge med. Mærkevareindustrien har været central i udbredelsen og normaliseringen af racistiske forståelser af...
Directory of Open Access Journals (Sweden)
Orhan Çiftci
2015-08-01
Full Text Available The purpose of this study is to explore the opinions of mathematics teachers working in high schools on the high school mathematics curriculum that was reformed in 2013. Structured interview method was employed to collect data from nine high school teachers. Content and descriptive analysis were used to analyze the data obtained from the interviews with teachers. Based on the qualitative analysis of data, the teachers favored the reduction in the content and acquisition regulation, but criticized some eliminated content and acceptance the level of readiness of students. The teachers believed the benefit of using compass-straightedge, information and communication technologies. Furthermore, the teachers expected more professional development opportunities, particularly on the use of technology for teaching mathematics before they are hold accountable for the implementation of the new curriculum. [Bu çalışmada, ortaöğretim kurumlarında görev yapan matematik öğretmenlerinin 2013 yılında yayınlanan ortaöğretim matematik dersi öğretim programı hakkındaki görüşlerini ortaya çıkarmak amaçlanmıştır. Veriler dokuz lise matematik öğretmeni ile gerçekleştirilen yapılandırılmış görüşmeler ile elde edilmiştir. Öğretmenlerle yapılan görüşmeler sonucunda elde edilen verilerin analizi için içerik ve betimsel analizi kullanılmıştır. Çalışmadan elde edilen verilerin analizi sonucunda, öğretmenler yeni programı, konuların yoğunluğunun azaltılması ve kazanımların düzenlenmesi gibi konularda olumlu bulmuş; bazı konuların çıkartılması ve öğrencilerin hazır bulunuşluk düzeylerinin kabulü konusunda eleştirmişlerdir. Öğretmenler, bilgi ve iletişim teknolojilerini ve pergel-cetveli kullanmanın faydalı olacağını belirtmişlerdir. Ayrıca, bilgi ve iletişim teknolojilerini kullanma konusunda desteklenmelerini ve programın öğretmenlere ayrıntılı olarak tanıtılmasını önermişlerdir.
Directory of Open Access Journals (Sweden)
Esra Aksoy
2015-12-01
Full Text Available Abstract The aim of this study was to examine mathematically gifted students' learning styles through data mining method. ‘Learning Style Inventory’ and ‘Multiple Intelligences Scale’ were used to collect data. The sample included 234 mathematically gifted middle school students. The construct decision tree was examined predicting mathematically gifted students’ learning styles according to their multiple intelligences and gender and grade level. Results showed that all the variables used in the study had a significant effect on mathematically gifted students’ learning styles, but the most effective attribute found was intelligence type. Key Words: mathematically gifted students, educational data mining, learning style, multiple intelligences Öz Bu çalışmanın amacı, matematik alanında üstün yetenekli öğrencilerin öğrenme stillerini veri madenciliği yöntemini kullanarak incelemektir. Veri toplama aracı olarak ‘Öğrenme Stili Envanteri’ ve ‘Çoklu Zeka Ölçeği’ kullanılmıştır. Araştırmanın örneklemi, 234 matematik alanında üstün yetenekli ortaokul öğrencisinden oluşmaktadır. Matematik alanında üstün yetenekli öğrencilerin öğrenme stillerini çoklu zeka alanları, cinsiyetleri ve sınıf seviyelerine göre tahmin etmek için oluş- turulan karar ağacı incelenmiştir. Sonuç olarak tüm değişkenlerin üstün yetenekli öğrencilerin öğrenme stilleri üzerinde etkisi olduğu fakat en etkili değişkenin çoklu zeka alanı olduğu gözlenmiştir. Anahtar Sözcükler: matematikte üstün yetenekli öğrenciler, eğitimsel veri madencili- ği, öğrenme stili, çoklu zeka
Kan migration føre noget godt med sig?
DEFF Research Database (Denmark)
Pærregaard, Karsten
2008-01-01
Som regel har den globale migration rod i økonomisk ulighed, social uretfærdighed eller politisk forfølgelse i de lande, hvor migranterne kommer fra og for mange migranter. Mange år efter, at disse har fundet sig til rette og tilpasset sig de samfund, som har migreret til, fortsætter deres families...... hjemlandsbyer i Peru. Artiklen er baseret på et antropologisk forskningsprojekt, som jeg gennemførte fra 2003-2006 blandt peruanere i USA, Spanien, Japan og Argentina. Udgivelsesdato: September...
DEFF Research Database (Denmark)
Hendricks, Vincent Fella; Vestergaard, Mads
Politik og medier oversvømmes af fordrejninger, fortielser, forglemmelser og forvanskninger af sandheden. Vi invaderes af populistiske fortællinger, “alternative kendsgerninger” og “fake news”. Det er nu et faktum, at misinformation er noget man aktivt må forholde sig til som politiker, som...... for virkelige udfordringer, vi står over for. FAKE NEWS giver et første sammenhængende billede af hvordan opmærksomhedsøkonomien kan ende i det postfaktuelle demokrati: Eventyrlige fortællinger erstatter kendsgerninger som grundlag for politisk meningsdannelse, debat og lovgivning. Et monster, som de færreste...
Indeklima - Materialer - Byggeri
DEFF Research Database (Denmark)
Jensen, Jens Kristian Jehrbo
I dette hæfte behandles emnerne INDEKLIMA MATERIALER BYGGERI med henblik på at opnå en forståelse af de begreber, der har betydning for menneskets velvære. Nogle af de vigtigste indeklimabegreber gennemgås og materialers fordele og ulemper belyses. Emner som afgasning, materialevalg, depoteffekt...... efter behov. Hæftet erstatter det tidligere hæfte: "Noget om indeklima - især om materialer" fra 1988. Renskrivningen er foretaget af Mette Bjerring, og tegninger og fotos er færdiggjort af Ingrid Christensen. Begge bedes modtage min hjerteligste tak. Juli 1992. Jens Kr. Jehrbo Jensen...
DEFF Research Database (Denmark)
Poder, Poul
2005-01-01
Empowerment er et af tidens plus ord og betyder direkte oversat bemyndige eller sætte i stand. Det er et begreb, der sætter fokus på processer, hvor igennem mennesker bliver i stand til at modvirke afmagt og afhængighed. Målet er refleksive og myndige mennesker og aktører, med stemme og handlings......Empowerment er et af tidens plus ord og betyder direkte oversat bemyndige eller sætte i stand. Det er et begreb, der sætter fokus på processer, hvor igennem mennesker bliver i stand til at modvirke afmagt og afhængighed. Målet er refleksive og myndige mennesker og aktører, med stemme og...... empowerment interessen. Akademisk set er empowermentbegrebet nemlig ikke noget stærkt begreb, der nyder anerkendelse i akademia. Jeg vil imidlertid argumentere for at et kritisk transformativt empowermentperspektiv fortjener at blive mere indholdsudfyldt. Det handler grundlæggende om et samfundskritisk og...
DEFF Research Database (Denmark)
Rosenstand, Claus Andreas Foss
det digitale domæne ud over det niveau, der kendetegner den nuværende debat, så præsenteres der ny viden om digital disruption. Som noget nyt udlægges Clayton Christens teori om disruptiv innovation med et særligt fokus på små organisationers mulighed for eksponentiel vækst. Specielt udfoldes...... forholdet mellem disruption og den stadig accelererende digitale udvikling i konturerne til ny teoridannelse om digital disruption. Bogens undertitel ”faretruende og fascinerende forandringer” peger på, at der er behov for en nuanceret debat om digital disruption i modsætning til den tone, der er slået an i...... videre kalder et ”disruption-råd”. Faktisk er rådet skrevet ind i 2016 regeringsgrundlaget for VLK-regeringen. Disruption af organisationer er ikke et nyt fænomen; men hastigheden, hvormed det sker, er stadig accelererende. Årsagen er den globale mega-trend: Digitalisering. Og derfor er specielt digital...
DEFF Research Database (Denmark)
Kjærgaard, Peter C.
2009-01-01
Charles Darwin blev født d. 12. februar 1809. Hans mest berømte bog, 'Om arternes oprindelse', udkom d. 24. november 1859. Det gør 2009 til noget ganske særligt for både Darwin og evolutionsteorien. Det er nemlig i år både Darwins 200-års fødselsdag og 150-års jubilæet for en af de mest...
Studerende skal trænes i transfer
DEFF Research Database (Denmark)
Wahlgren, Bjarne
2013-01-01
Der er stor forskel på at kunne handle og at handle. Og der er stor forskel på at lære noget i pædagoguddannelsen og så faktisk anvende det, man har lært. Forskellen handler om transfer, som er blevet et nøglebegreb for professionsuddannelserne. Transfer er et klassisk pædagogisk begreb, der...... betyder, at det, der er lært i en situation, transformeres til anvendelse i 21 en anden situation. Den seneste evaluering af pædagoguddannelsen peger på, at der ikke er den optimale transfer mellem skole og praksis. Derfor er der kommet fornyet fokus på transfer i de senere år. Artiklen gennemgår begrebet...... transfer i pædagoguddannelsen og analyserer tre pædagogiske udfordringer, som uddannelsen står over for. En udfordring er at tilrettelægge kompetenceudviklingen, så der skabes den bedst mulige sammenhæng mellem det, der sker på skolen, og det, der foregår i praktikken. Jo tættere denne sammenhæng er...
De Kreative Erhverv - Glem Kunsten
DEFF Research Database (Denmark)
Andersson, Lasse
2014-01-01
arbejdspladser skabes i brancher, der kan skaleres. HVOR LIGGER FREMTIDENS Apple, nye brand-guruer som Martin Lindstrøm eller morgendagens Jørn Utzon gemt. Aalborg Universitet uddanner tæt på 500 kandidater årligt inden for de kreative erhverv -ofte med en stærk teknologisk vinkel. Vi har dermed en mulighed...... erhverv i Nordjylland for ca. 11 mia. og beskæftigede 5500 personer. Heri gemmer sig en del engroshandel og produktionsvirksomhed, så skærer vi ind til kernen af de brancher, som er nævnt tidligere, er tallet noget mindre og tættere på fire mia. Det sidste er et mere reelt tal, når man skal se det reelle...
DEFF Research Database (Denmark)
Jordt Jørgensen, Nanna
2006-01-01
Folk bliver nødt til at gå i gang med at arbejde. Måske er det bare at anlægge en have eller at sælge æbler foran huset, men det forandrer noget. Man bliver selvstændig og selvforsynende, man ved, at man er på rette vej. Folk skal holde op med at være bivogne, der bare læner sig op ad andre. De s...... skal stå på egne ben og hjælpe sig selv. Vi må holde op med at skyde skylden på apartheid, det er på høje tid, at vi begynder at arbejde for os selv! (ansat i en sydafrikansk ngo)....
En didaktisk model for Flipped Classroom
DEFF Research Database (Denmark)
Levinsen, Henrik; Foss, Kristian Kildemoes; Andersen, Thomas Dyreborg
2016-01-01
I artiklen præsenterer vi en model over flipped classroom som didaktisk metode udviklet med henblik på at stilladsere både de lærere, som gerne vil prøve kræfter med en flipped classroom-baseret praksis, og dem som allerede har erfaring, men kan have glæde af at bruge modellen til at kvalificere...... deres flipped classroom-undervisning. Modellen kan bidrage til erkendelsen af, at flipped classroom er noget nær et paradigmeskifte i forståelsen af god undervisning. Her tænkes på det skift i fokus metoden indebærer fra, at læreren er mest aktiv, til at eleverne er de mest aktive. Særligt for den...
Brug af mindfulness til facilitering
DEFF Research Database (Denmark)
Adriansen, Hanne Kirstine; Krohn, Simon
2011-01-01
Gennem de senere år er mindfulness gået fra udelukkende at være en eksistentiel praksis til også at være en behandlingsform og senest til også at blive brugt som et praktisk redskab i erhvervslivet. Denne artikel viser, at mindfulness også kan anvendes i forbindelse med facilitering. Facilitering...... er et værktøj, som bruges i arbejdslivet fx til møder og konferencer, hvor en gruppe mennesker er samlet for at lære eller udrette noget sammen. Det nye ved at kombinere mindfulness med facilitering er, at fokus hermed ændres fra individet, som er centrum for den eksistentielle fordybelse eller det...... terapeutiske forløb, til gruppen, som er udgangspunktet i facilitering. Artiklen viser, hvordan mindfulness konkret kan bruges på gruppeniveau og diskuterer samtidig hvilke problemer, der kan være forbundet hermed. Baseret på vores egne erfaringer, diskuterer vi, hvordan mindfulness kan påvirke en gruppes...
Hvad kan du tilbyde mig som muslim, præst?
DEFF Research Database (Denmark)
Skovsgaard, Steen
2005-01-01
. islam og kristendom var jeg i 1995 inviteret til et møde med en stor gruppe muslimer i Gellerup. Det var et debatmøde om islam og kristendom, hvor skoleleder og imam Abdul Wahid Pedersen og jeg skulle komme med oplæg og debattere. Og så kunne der efterfølgende stilles spørgsmål fra salen. Det var hér...... andre mennesker, eller om Gud elsker dig og vil ha’ noget med dig at gøre, den dag må du love mig at komme tilbage. For så har jeg noget at tilbyde dig. Indtil da må du nøjes med islam!” Et sådant svar ville ganske vist ha’ været længere, men der ville også ha’ været mere for den unge muslim at tænke på...... og overkommelige krav, som stilles dig i islam. Selv her har du svigtet og er skyldig! Skyldig til dom og til straf!”. Og hvis så muslimen skulle finde på at sige, at han da bestemt har opfyldt Guds vilje iflg. islam, så kan vi jo passende fortælle ham, at de krav som stilles i islam kun er en bleg...
Thermodynamic assessments of the Ag-Er and Er-Y systems
International Nuclear Information System (INIS)
Wang, S.L.; Wang, C.P.; Liu, X.J.; Tang, A.T.; Pan, F.S.; Ishida, K.
2010-01-01
The phase diagrams and thermodynamic properties in the Ag-Er and Er-Y binary systems have been assessed by using the CALPHAD (Calculation of Phase Diagrams) method on the basis of the experimental data including the thermodynamic properties and phase equilibria. The Gibbs free energies of the liquid, bcc, fcc, and hcp phases were described by the subregular solution model with the Redlich-Kister equation, and those of intermetallic compounds (Ag 2 Er and AgEr phases) were treated as stoichiometric compounds, and Ag 51 Er 14 phase was modeled by the sublattice model in the Ag-Er binary system. The thermodynamic parameters of the Ag-Er and Er-Y binary systems were obtained, and an agreement between the calculated results and experimental data was obtained for each binary system.
Directory of Open Access Journals (Sweden)
Berna Aygün
2016-04-01
Full Text Available In this study, the contents and types of elementary 6th, 7th, 8th grades’ mathematics exam questions are analyzed according to groups and categories of the MATH taxonomy. In order to achieve this aim documentary analysis research and Chi-square test are used and the analyses of questions are based on the definitions of groups and categories of the MATH taxonomy. Analyzed questions consist of 939 questions which are collected from mathematics classes of different schools at East Blacksea regions. In all of the questions, 260 are at 6th grade (27.7%, 327 are at 7th grade (34.8%, and 352 are at 8th grade (37.5% mathematics written exam questions. According to the results, two in every three questions used by instructors in math exams are at A3 "Routine use of Procedures" level in which the use of the procedure or algorithm is required to use properly. Most of the questions are from category A which contains routine procedures and basic abilities. in addition to this, there are fewer questions at category B which is required the higher order thinking skill, and scarcely any questions at higher-up thinking level, category C. [Bu çalışmada ilköğretim 6., 7. ve 8. sınıfların matematik dersi sınav sorularının ait olduğu öğrenme alanlarının ve soru türlerinin MATH taksonomi grup ve kategorilerine göre incelenmesi amaçlanmıştır. Bu amaç doğrultusunda çalışmada karma yöntem kullanılmış ve sorular MATH Taksonomi Grup ve Kategorilerine ait açıklamalar temel alınarak doküman incelemesi ve ki-kare testi ile analiz edilmiştir. İncelenen sorular, Doğu Karadeniz bölgesindeki çeşitli okullardaki matematik dersi sınavlarında sorulan toplam 939 sorudan oluşmaktadır. Bu sorulardan 260 tanesi (% 27,7 6. sınıf, 327 tanesi (% 34,8 7. sınıf, 352 tanesi (% 37,5 ise 8. sınıf matematik dersi yazılı sınav sorularıdır. Elde edilen bulgulara göre öğretmenlerin matematik dersi sınavlarında kullandıkları her 3
Notat vedr. muligheder for at styrke det faglige niveau i matematik og naturfag
DEFF Research Database (Denmark)
Busch, Henrik; Horst, Sebastian
Dette notat er i foråret 2005 udarbejdet af Henrik Busch og Sebastian Horst for Undervisnings-ministeriet i forbindelse med forberedelsen til Globaliseringsrådets arbejde i efteråret 2005. Notatet er i november 2005 gjort offentligt tilgængeligt efter aftale med Undervisningsministeriet. I den fo...
Genfortryllelse i den digitale tidsalder
DEFF Research Database (Denmark)
Madsen, Theis Vallø
, hvilket bl.a. kommer til udtryk i en ny vinylplade- og polaroidbillede-interesse. Denne undersøgelse går tilbage til begyndelsen af oplysningstiden, op igennem det 20. århundrede og frem til vores digitale kultur for at beskrive baggrunden og forestillingerne bag denne form for “analog æstetik”.......I den digitale tidsalder bliver uhyre mængder af information, billeder og musik noget nær frit tilgængelige, uendeligt reproducérbare og frigjort fra sit ”her” og ”nu”. I samme stund er der opstået en fornyet interesse for artefakter, der er stoflige, håndgribelige og u- eller anti-digitale...
Landmann, Alessandra; Farrugia, Daniel J; Zhu, Li; Diego, Emilia J; Johnson, Ronald R; Soran, Atilla; Dabbs, David J; Clark, Beth Z; Puhalla, Shannon L; Jankowitz, Rachel C; Brufsky, Adam M; Ahrendt, Gretchen M; McAuliffe, Priscilla F; Bhargava, Rohit
2018-05-08
Pathologic complete response (pCR) rate after neoadjuvant chemotherapy was compared between 141 estrogen receptor (ER)-negative (43%), 41 low ER+ (13%), 47 moderate ER+ (14%), and 98 high ER+ (30%) tumors. Human epidermal growth factor receptor 2-positive cases, cases without semiquantitative ER score, and patients treated with neoadjuvant endocrine therapy alone were excluded. The pCR rate of low ER+ tumors was similar to the pCR rate of ER- tumors (37% and 26% for low ER and ER- respectively, P = .1722) but significantly different from the pCR rate of moderately ER+ (11%, P = .0049) and high ER+ tumors (4%, P < .0001). Patients with pCR had an excellent prognosis regardless of the ER status. In patients with residual disease (no pCR), the recurrence and death rate were higher in ER- and low ER+ cases compared with moderate and high ER+ cases. Low ER+ breast cancers are biologically similar to ER- tumors. Semiquantitative ER H-score is an important determinant of response to neoadjuvant chemotherapy.
Directory of Open Access Journals (Sweden)
Sigit Triwahyudi
2016-12-01
ini menyajikan uji unjuk kerja dan pemodelan matematik pengering energi surya (ERK-Hibrid menggunakan rak berputar secara vertikal. Pengering terdiri dari bangunan rumah kaca berukuran (1100 × 860 × 1300 mm dengan delapan buah rak dan sistim pemanas tambahan yang terdiri dari kolektor plat datar (1,04 m2, tangki penyimpan air panas (197 liter dan penukar panas. Untuk mengetahuikinerja pengering energi surya, dilakukan lima kali percobaan variasi kecepatan putar rak (1, 4, 7, 10 rpm dan tanpa pemutaran rak. Bahan yang dipergunakan pada pengujian adalah kapulaga lokal (Amomum cardamomum Wild. Masing-masing percobaan seberat 9 sampai dengan 10 kg. Rata-rata suhu air tangki penyimpan panas bervariasi dari 50,0 sampai dengan 55,0 °C suhu ruang pengering antara 38,9 sampai dengan 45,9 °C, sedangkan kelembaban relatif (RH ruang pengering berkisar antara 32,1 sampai dengan 47,4 %. Perlakuan pemutaran rak berpengaruh terhadap keseragaman suhu bahan maupun kadar air pada masing rak pengering. Pada perlakuan pemutaran 1 rpm (percobaan II, didapatkan kondisi terbaik (suhu bahan maupun kadar air yang paling seragam. Dengan kecepatan putar rak yang semakin meningkat menyebabkan nilai ragam suhu bahan maupun kadar air semakin meningkat. Untuk melakukan simulasi unjuk kerja dilakukan pemodelan matematik berdasarkan pindah panas dan massa serta pendekatan pengeringan lapisan tipis. Persamaan diselesaikan secara numerik menggunakan finite difference Euler dengan bantuan bahasa pemrograman Visual Basic Aplication (VBA Excell. Validasi dilakukan dengan membandingkan antara perhitungan hasil pemodelan (data prediksi dengan data hasil pengukuran (data observasi. Kriteria kevalidan ditentukan dengan melihat nilai koefisien determinasi (R2, nilai RMSD maupun nilai MAPD. Pemodelan matematik yang telah dibangun dapat menggambarkan dengan tepat perubahan suhu air tangki penyimpan panas, suhu ruang pengering, suhu bahan maupun penurunan kadar air. Kata kunci: Pengering surya efek rumah
DEFF Research Database (Denmark)
Levisen, Vinie Diana Hvidbak; Castaño, Francisco Mansilla; Jensen, Camilla Skovbjerg
2017-01-01
Baggrund Mænds mobile sundhed bidrager med viden om, hvordan mobile sundhedsapplikationer påvirker det fysiske aktivitetsniveau hos mænd med kort eller ingen uddannelse samt hyppigheden af, hvor ofte de tænker og gør noget for at fremme egen fysiske sundhed. Mænd med kort eller ingen uddannelse......, har både den laveste middellevetid og længste patient delay, og på nuværende tidspunkt er der ikke gennemført forskning med mobile sundhedsapplikationer som sundhedsfremmende intervention til denne målgruppe. Projektets resultater og viden kan anvendes af både arbejdspladserne, sundhedsvæsnet og...... (N=71): BT, puls, konditest, fordeling af fedt og muskelmasse. Visuel Analog Scale (VAS) af hvor ofte manden tænker på egen sundhed, VAS af hvor ofte manden gør noget for at fremme egen sundhed. Interventionsperioden 6 måneder: Interventionsgruppen anvender mobil applikation, registrering af skridt...
Co-Design: Alzheimer og værdighed
DEFF Research Database (Denmark)
Brandt, Eva; Risak, Gudrun; Otterstrøm Nørgaard, Andrea
2012-01-01
”Alzheimers er ikke en identitet, det er en sygdom!” fortalte en netop Alzheimer diagnosticeret mand. Udtalelsen illustrerer hvordan mange med Alzheimer bliver opfattet og behandlet. De bliver stigmatiserede og konsekvensen er ofte social isolation. Denne artikel rapporterer fra studenterprojekter....... Via en overordnet co-designtilgang har de undersøgt hverdagens udfordringer, forhåbninger og bekymringer hos mennesker, der lever med Alzheimers enten som ramt eller som pårørende. Ved at designe forskellige ’dialogværktøjer’ er de kommet med konkrete bud på, hvordan dialog omkring hverdagsliv med...... Alzheimers kan finde sted. Et værdigt liv og en værdig behandling forudsætter at kendskabet til sygdommens mange ansigter udbredes. Designere kan her bidrage med noget vigtigt. Designere har greb og kompetencer til at kunne etablere og håndtere designprocesser, der involverer patienter, pårørende...
Hvis en kartoffel er forkert, hvad er en Mars-bar så?
DEFF Research Database (Denmark)
Lichtenstein, Mia Beck; Thomsen, Freja; Hinze, Cecilie
2016-01-01
Danske unge er de slankeste af 41 europæiske unge, men de føler sig ofte tykke og går på slankekur. Hvad er årsagen, og hvorfor er det et problem?......Danske unge er de slankeste af 41 europæiske unge, men de føler sig ofte tykke og går på slankekur. Hvad er årsagen, og hvorfor er det et problem?...
ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology.
Manford, Andrew G; Stefan, Christopher J; Yuan, Helen L; Macgurn, Jason A; Emr, Scott D
2012-12-11
Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic approach, we identified three families of ER-PM tethering proteins in yeast: Ist2 (related to mammalian TMEM16 ion channels), the tricalbins (Tcb1/2/3, orthologs of the extended synaptotagmins), and Scs2 and Scs22 (vesicle-associated membrane protein-associated proteins). Loss of all six tethering proteins results in the separation of the ER from the PM and the accumulation of cytoplasmic ER. Importantly, we find that phosphoinositide signaling is misregulated at the PM, and the unfolded protein response is constitutively activated in the ER in cells lacking ER-PM tether proteins. These results reveal critical roles for ER-PM contacts in cell signaling, organelle morphology, and ER function. Copyright © 2012 Elsevier Inc. All rights reserved.
RFiD tracking af brugeres adfærd i bygningsrum
DEFF Research Database (Denmark)
Suenson, Valinka; Harder, Henrik
2011-01-01
dette felt. Forude venter derfor flere forsøg, førend forskningsfeltet kan siges at være metodisk veletableret. Radio Frequency Identification (RFID), videoovervågning og Bluetooth er alle metoder, der bliver forsket i. Adfærdsanalyser i bygninger er med andre ord et både levende og dynamisk felt, og...... metoderne fornyr sig i takt med, nye teknologier opstår. I nærværende artikel vil det blive belyst hvordan RFID teknologien kan bruges til at gennemføre en adfærdsanalyse af et eller flere bygningsrum. Forskningen anvender teknologien til at sige noget om brugen af bygningen. Hvordan bruges den? Hvem bruger...
Åben innovation i virksomhedsnetværk: Et spørgsmål om lederskab?
DEFF Research Database (Denmark)
Goduscheit, René Chester
2007-01-01
form af eksempelvis virksomhedsnetværk, er således stigende. Det viser sig bare, at det ikke er nok at ringe til nogle relevante virksomheder og bede dem om at komme og 'hjælpe dem med at lave noget innovation'. Alt for mange netværk lider en hurtig død - ressourcerne i de enkelte virksomheder og...... synergien mellem dem realiseres kun i meget begrænset omfang. Netværksmøderne bliver blot hyggelige sammenrend uden et konkret udbytte i form af nye produkter, services etc. Artiklen beskriver, hvordan virksomheder, som ønsker at skabe og udvikle et virk-somhedsnetværk omkring innovation, kan lede netværket...
DEFF Research Database (Denmark)
Hartley, Jannie Møller; Eberholst, Mads Kæmsgaard
2016-01-01
Facebook’s demokratiske potentiale er stort, og både danske læsere og danske medier har i stor grad adopteret Facebook. Det giver adgang til brugere og disse kan engageres især via kommentarsporet på de historier, medierne slår op på Facebook. Med afsæt i 149 Facebook-opslag og deres tilhørende...... ellers har været forbeholdt medierne. Overordnet kan vi konkludere at debattonen på de sociale medier er relativt neutral, at brugerne faktisk mener noget, når de debatterer. Desuden kan vi konkludere, at medierne endnu ikke behøver at frygte, at Facebook-debattører fratager journalisterne deres levebrød....
Universiteter bør prioritere undervisningen
DEFF Research Database (Denmark)
Hyldgaard, Kirsten
2017-01-01
akkreditering af uddannelser. Styringsredskabet er kun kontrol, ikke incitamenter. Man kan ikke blive professor, hvis man lægger ekstraordinært megen energi i forberedelse af undervisning og udvikling af uddannelser. Jeg har i det mindste aldrig hørt om, at et professorat blev begrundet med kvalifikationer i...... er lønforhøjelser og professorater. Den retning, ledelsen leder os i, er imidlertid ikke forskningen som sådan, snarere det at skrive forskningsrådsansøgninger med henblik på at indhente eksterne forskningsmidler. Man kan blive professor, hvis man kan hente eksterne forskningsmidler hjem til ens...... noget, der kunne og burde bidrage til forskningen. Man skulle tro, at når der ingen prestige er forbundet med at være en dygtig underviser, ville man netop se behovet for incitamenter. Det gør man ikke – ud over den årlige præmiering af ”Årets underviser”. Studerende kan naturligvis være fuldstændigt...
Directory of Open Access Journals (Sweden)
Esat Avcı
2016-08-01
Full Text Available In this study, secondary school students' academic risk-taking behaviours have been investigated to understand whether they vary according to some variables or not. These variables are: Gender, grade level, town, type of school, parents education level, economic status of the family, the previous year's maths scores. Survey method was used in the study. The population is students who are studying in secondary schools located in Akdeniz, Mezitli, Toroslar and Yenişehir provinces of Mersin, in the 2014 - 2015 academic year. The research sample is 1054 students who are studying at 14 of these schools. “Mathematics-oriented academic risk taking behaviors scale” was used for data collection. Data for the analysis of independent samples t-test and ANOVA were used. There is no significant variance between maths-oriented academic risk-taking behaviours of students based on variables such as gender, town, school type and economic status of the family whereas there is meaningful variance based on variables such as grade level, level of parents education and last year's mathematics score. [Bu araştırmada ortaokul öğrencilerinin akademik risk alma davranışlarının bazı değişkenlere göre farklılık gösterip göstermediği araştırılmıştır. Bu değişkenler şunlardır: Cinsiyet, sınıf düzeyi, ilçe, okul türü, anne ve baba eğitim düzeyi, ailelerin ekonomik durumu, bir önceki seneki matematik puanları. Çalışmada tarama yöntemi kullanılmıştır. Araştırma evreni, 2014 – 2015 eğitim öğretim yılında Mersin ili Akdeniz, Mezitli, Toroslar ve Yenişehir ilçelerinde bulunan ortaokullarda okumakta olan öğrencilerdir. Araştırma örneklemi ise bu okullardan 14 tanesinde okumakta olan 1054 öğrencidir. Veri toplama aracı olarak “Matematik Odaklı Akademik Risk Alma Ölçeği” kullanılmıştır. Verilerin analizi için bağımsız örneklem t testi ve ANOVA uygulanmıştır. Öğrencilerin matematik odakl
Directory of Open Access Journals (Sweden)
Melike Yiğit Koyunkaya
2017-08-01
Full Text Available The main purpose of this study was to examine pre-service secondary mathematics teachers’ (PSMTs levels and development of technological, pedagogical and content knowledge (TPACK. In line with this purpose, this study was designed to use teaching experiment methodology within a course. Therefore, while examining PSMTs’ development of TPACK, an appropriate teaching method that supported development of PSMTs’ TPACK was shared in this article. The participants of the study were 28 fourth grade PSMTs. The teaching experiment methodology, one of the methods of qualitative research design, was used in the study. By using this method, PSMTs were taught about how to integrate technology into mathematics education, how to use varios mathematics and geometry dynamic software, interactive applications that are used in mathematics education and various websites related to education during 16 weeks and four hours in each week. The data was collected during the experiment, and analyzed by using content analysis and document analysis methods. The results show that PSMTs’ TPACK levels were developed by applying the teaching experiment methodology. Particularly, in the activities they designed, lesson plans, reflections and free writings, it was observed that PSMTS’ skills about how to integrate technology in order to ease the learning and teaching of mathematics and utilizing it were developed. Within this context, it is thought that technology integrated courses or technology based courses should be taught in the education programs. [Bu çalışmanın temel amacı, ortaöğretim matematik öğretmeni adaylarının teknolojik pedagojik alan bilgi (TPAB düzeylerinin ve gelişimlerinin incelenmesidir. Bu amaç doğrultusunda, bu çalışma bir ders kapsamında öğretim deneyi yöntemi kullanılarak tasarlanmıştır. Çalışmanın katılımcıları, bir devlet üniversitesinin Ortaöğretim Matematik Öğretmenliği bölümünde öğrenim gören 28
Kontext+7, Lærervejledning og web
DEFF Research Database (Denmark)
Hansen, Niels Jacob; Johnsen, Lars Busch; Lindhardt, Bent Kofod
KonteXt+7 Lærervejledning/Web består af en trykt lærervejledning og et tilhørende website: kontextplus.dk. Lærervejledningen indeholder en didaktisk del, en side til side-vejledning og en evalueringsdel. Web-delen indeholder arbejdsark, hjælpeark, serviceark og evalueringsark til hvert kapitel til...... i matematik KonteXt + 7, Kernebog/Web er klar på lager første uge i august. De to første kapitler vil blive lagt på kontextplus.dk, så du har mulighed for at forberede din undervisning i god tid....
Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER
Directory of Open Access Journals (Sweden)
Elisa Greotti
2016-09-01
Full Text Available Calcium ion (Ca2+ is a ubiquitous intracellular messenger and changes in its concentration impact on nearly every aspect of cell life. Endoplasmic reticulum (ER represents the major intracellular Ca2+ store and the free Ca2+ concentration ([Ca2+] within its lumen ([Ca2+]ER can reach levels higher than 1 mM. Several genetically-encoded ER-targeted Ca2+ sensors have been developed over the last years. However, most of them are non-ratiometric and, thus, their signal is difficult to calibrate in live cells and is affected by shifts in the focal plane and artifactual movements of the sample. On the other hand, existing ratiometric Ca2+ probes are plagued by different drawbacks, such as a double dissociation constant (Kd for Ca2+, low dynamic range, and an affinity for the cation that is too high for the levels of [Ca2+] in the ER lumen. Here, we report the characterization of a recently generated ER-targeted, Förster resonance energy transfer (FRET-based, Cameleon probe, named D4ER, characterized by suitable Ca2+ affinity and dynamic range for monitoring [Ca2+] variations within the ER. As an example, resting [Ca2+]ER have been evaluated in a known paradigm of altered ER Ca2+ homeostasis, i.e., in cells expressing a mutated form of the familial Alzheimer’s Disease-linked protein Presenilin 2 (PS2. The lower Ca2+ affinity of the D4ER probe, compared to that of the previously generated D1ER, allowed the detection of a conspicuous, more clear-cut, reduction in ER Ca2+ content in cells expressing mutated PS2, compared to controls.
DEFF Research Database (Denmark)
Steenbuch, Johannes Aakjær
2011-01-01
Der er ikke længere nogen højere sandhed i livet end den, flertallet bestemmer sig for – og dermed ingen del af livet, der ikke er politisk. Højre- og venstrefløjen er i bund og grund enige - enige om, at det er politikernes opgave at forære os det gode liv. Dermed bliver demokratiet totalitært. ...
Brand management og den refleksive forbruger - med semiotik som hjælpedisciplin
DEFF Research Database (Denmark)
Hermansen, Judy
2009-01-01
Kritisk eftertanke er et væsentligt træk ved den refleksive forbruger - ofte parret med en vis negativitet overfor et brand, en reklame eller forbrugerisme i al almindelighed. Den refleksive forbrugertype kommer til udtryk hos for eksempel en anti-branding guru som Naomi Klein og hendes...... bestseller bog "No Logo" eller i græsrodsbevægelsen Adbusters ( https://www.adbusters.org/ ), der efterhånden i mange år har udsendt et månedsmagasin med kritik af forbrugersamfundet og al dets reklame og branding. Disse anti-forbrugs og anti-branding bevægelser udspringer af, og er identifikationspunkter...... - den refleksive forbruger skal have noget, der kan "brande" ham som anderledes end alle mainstreamforbrugerne. Den refleksive forbruger er med andre ord en Feinschmecker og i lighed med - eller måske rettere i endnu højere grad end - alle andre forbrugere signalerer den refleksive forbruger sin...
Matematik dersi 1.-5. sınıf öğretim programının NCTM prensip ve standartlarına göre incelenmesi
UMAY, AYSUN; ÇIKLA, OYLUM AKKUŞ; DUATEPE, ASUMAN
2006-01-01
Milli Eğitim Bakanlığı tarafından 2004-2005 öğretim yılında uygulanmak üzere hazırlanan yeni öğretim programları, eğitimdünyasındaki çağdaş gelişimleri yakalamak için önemli bir adım sayılabilir. Bu çalışmada İlköğretim 1.-5. sınıf Matematik DersiÖğretim Programı (İMDÖP), NCTM tarafından 2000 yılında hazırlanan, okul matematiği için dikkate alınması gereken prensip vestandartları açıklayan Principles and Standards for School Mathematics (PSSM) adlı dokümanı ölçüt alınarak incelenmiştir. Budok...
DEFF Research Database (Denmark)
Mehlsen, Camilla
2006-01-01
Urolige elever, cyklister - der giver fuck-finger, aggressive demonstranter. Samtiden er på vej ind i en æra domineret af vrede, siger rektor Lars-Henrik Schmidt, der er aktuel med bogen 'Om vreden'. Udgivelsesdato: Juni......Urolige elever, cyklister - der giver fuck-finger, aggressive demonstranter. Samtiden er på vej ind i en æra domineret af vrede, siger rektor Lars-Henrik Schmidt, der er aktuel med bogen 'Om vreden'. Udgivelsesdato: Juni...
DEFF Research Database (Denmark)
Schaumburg-Müller, Sten
2009-01-01
En redegørelse for forholdet mellem blasfemi, ytringsfrihed og religionsforhånelse. Der argumenteres endvidere for at blasfemibestemmelsen i den danske straffelov ikke udtrykker gældende ret, at det stedse er vanskeligt at finde en balance mellem den vigtige ytringsfrihed og de nødvendige indskræ...... indskrænkninger (såsom børneporne, opfordringer til vold og folkemord) og at beskyttelse af religion ikke har noget med menneskerettigheder at gøre og at forbud mod religionsforhånelse risikerer at stride mod menneskerettighederne....
COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.
Fang, Jingye; Liu, Ming; Zhang, Xuebao; Sakamoto, Takeshi; Taatjes, Douglas J; Jena, Bhanu P; Sun, Fei; Woods, James; Bryson, Tim; Kowluru, Anjaneyulu; Zhang, Kezhong; Chen, Xuequn
2015-08-01
Pancreatic β-cells possess a highly active protein synthetic and export machinery in the endoplasmic reticulum (ER) to accommodate the massive production of proinsulin. ER homeostasis is vital for β-cell functions and is maintained by the delicate balance between protein synthesis, folding, export, and degradation. Disruption of ER homeostasis by diabetes-causing factors leads to β-cell death. Among the 4 components to maintain ER homeostasis in β-cells, the role of ER export in insulin biogenesis is the least understood. To address this knowledge gap, the present study investigated the molecular mechanism of proinsulin ER export in MIN6 cells and primary islets. Two inhibitory mutants of the secretion-associated RAS-related protein (Sar)1 small GTPase, known to specifically block coat protein complex II (COPII)-dependent ER export, were overexpressed in β-cells using recombinant adenoviruses. Results from this approach, as well as small interfering RNA-mediated Sar1 knockdown, demonstrated that defective Sar1 function blocked proinsulin ER export and abolished its conversion to mature insulin in MIN6 cells, isolated mouse, and human islets. It is further revealed, using an in vitro vesicle formation assay, that proinsulin was packaged into COPII vesicles in a GTP- and Sar1-dependent manner. Blockage of COPII-dependent ER exit by Sar1 mutants strongly induced ER morphology change, ER stress response, and β-cell apoptosis. These responses were mediated by the PKR (double-stranded RNA-dependent kinase)-like ER kinase (PERK)/eukaryotic translation initiation factor 2α (p-eIF2α) and inositol-requiring protein 1 (IRE1)/x-box binding protein 1 (Xbp1) pathways but not via activating transcription factor 6 (ATF6). Collectively, results from the study demonstrate that COPII-dependent ER export plays a vital role in insulin biogenesis, ER homeostasis, and β-cell survival.
Effects of material growth technique and Mg doping on Er3+ photoluminescence in Er-implanted GaN
International Nuclear Information System (INIS)
Kim, S.; Henry, R. L.; Wickenden, A. E.; Koleske, D. D.; Rhee, S. J.; White, J. O.; Myoung, J. M.; Kim, K.; Li, X.; Coleman, J. J.
2001-01-01
Photoluminescence (PL) and photoluminescence excitation (PLE) spectroscopies have been carried out at 6 K on the ∼1540 nm 4 I 13/2 - 4 I 15/2 emissions of Er 3+ in Er-implanted and annealed GaN. These studies revealed the existence of multiple Er 3+ centers and associated PL spectra in Er-implanted GaN films grown by metalorganic chemical vapor deposition, hydride vapor phase epitaxy, and molecular beam epitaxy. The results demonstrate that the multiple Er 3+ PL centers and below-gap defect-related absorption bands by which they are selectively excited are universal features of Er-implanted GaN grown by different techniques. It is suggested that implantation-induced defects common to all the GaN samples are responsible for the Er site distortions that give rise to the distinctive, selectively excited Er 3+ PL spectra. The investigations of selectively excited Er 3+ PL and PLE spectra have also been extended to Er-implanted samples of Mg-doped GaN grown by various techniques. In each of these samples, the so-called violet-pumped Er 3+ PL band and its associated broad violet PLE band are significantly enhanced relative to the PL and PLE of the other selectively excited Er 3+ PL centers. More importantly, the violet-pumped Er 3+ PL spectrum dominates the above-gap excited Er 3+ PL spectrum of Er-implanted Mg-doped GaN, whereas it was unobservable under above-gap excitation in Er-implanted undoped GaN. These results confirm the hypothesis that appropriate codopants can increase the efficiency of trap-mediated above-gap excitation of Er 3+ emission in Er-implanted GaN. [copyright] 2001 American Institute of Physics
DEFF Research Database (Denmark)
Hoffmeyer, Jesper
2013-01-01
Nu ved vi, at der er mange slags DNA i vores krop, og at samarbejdet mellem de organismer, som bærer alt dette DNA, er essentielt for vores overlevelse" … "Kroppen er en slags økosystem, hvor alle slags samarbejde hen ad vejen bliver afprøvet"...
DEFF Research Database (Denmark)
Christiansen, Rene B
2014-01-01
towards experimental description”. Denne definition er formuleret af Ference Marton og understreger at fænomenografien er optaget af beskrivelser af menneskers oplevelser, hvad an-går udvalgte sociale fænomener og samtidig at udpege variationer inden for disse sociale fænomener. Fænomenografi fokuserer på...... for at udfolde deres intentioner om lærerarbejde”? Det andet forskningsspørgsmål adresserede adgangsproblematikker i forhold til forskning i skolen og lød: ”Hvordan kan man få adgang til og hvordan skal man forstå skolens hverdagspraksisser”? Gennem afhandlingen er begge spørgsmål blevet diskuteret både...... var både tale om den faktiske, fysiske adgang til en skole, når man dukker op på matriklen og går omkring og ser, hvad der sker. I afhandlingen vises at der det mest af tiden ikke sker noget – der er rig mulighed for at gå omkring, med mindre man italesætter sin intention med at være der. Til eksempel...
DEFF Research Database (Denmark)
Thurah, Thomas
Fra omslaget: Petras tunge er et essay om noget af den litteratur, der skrives i Europa i disse år. En litteratur, der bliver til, mens eftertidens revisorer fører en ny sandhed til protokols, og mens Europa står midt i et uforudsigeligt opbrud. Bogen handler også om nogle af de europæiske...... hovedstæder, små og store metropoler, hvor historien har sat sig tydelige spor og endnu gør det for magtfuldt og tilsyneladende tvivlløst at bevidne en ny tingenes orden. Litteraturen skrives af bl.a. Martin Amis, Hanif Kureishi, Marcel Beyer, Günter Grass, Milan Kundera, Cees Nooteboom, Aldo Busi, Claudio...... Magris og Imre Kertész. Blandt de europæiske hovedstæder, der fortælles fra, er Berlin, Budapest, London, Bruxelles, Rom og Athen. Petras tunge er en bog om i dag, om europæernes fælles nutid. Men den er også forfatterens forsøg på for sig selv at finde ud af, hvad et menneske har at holde sig til...
DEFF Research Database (Denmark)
Johansen, Martin Blok
diskuteres. Det betyder, at spørgsmålet, "Hvad er dannelse?", bliver stadig mere påtrængende. Det definitive svar findes sandsynligvis ikke, men denne bog giver adskillige bud på, hvordan man kan forstå begrebet dannelse. Bogen indeholder bidrag fra videnskabelige medarbejdere på 20 af institutterne på......Siden ungdomsoprøret i 1968 har dannelse været et omdiskuteret og misbilliget begreb, der med sin dubiøse og altmodische klang blev identificeret med småborgerligt snobberi og ligegyldig viden. Imidlertid har man inden for de seneste år kunnet konstatere, at dannelse på ny er blevet noget, der...... Aarhus Universitet. Bidragene tager netop udgangspunkt i, hvordan man kan tænke på dannelse, når man som forsker er tilknyttet et af de mange institutter på universitetet. Bogen indledes med en introduktion til dannelsesbegrebet af den mangeårige rektor ved Aarhus Universitet, Henning Lehmann. Derefter...
Lyd som kommunikation. En tværfaglig forskningsoversigt og en dagsorden for medieforskningen
Directory of Open Access Journals (Sweden)
Klaus Bruhn Jensen
2008-06-01
Full Text Available Lyden har ikke noget videnskabeligt hjem – i modsætning til f.eks. faste og levende billeder, der traditionelt er blevet studeret af henholdsvis kunsthistorien og filmvidenskaben. Denne artikel giver en oversigt over de mange, meget forskellige slags forskning om lyd. Formålet er at stimulere og kvalificere mere medieforskning om lyd. Hovedvægten ligger på lyd som kommunikation i og omkring medierne – som en kilde til mening og en ressource i social og kulturel handling, snarere end på lyd i et teknisk eller akustisk perspektiv (se f.eks. Plomp, 2002. Første del af artiklen gennemgår forskellige humanistiske og samfundsvidenskabelige tilgange til lydens tre grundformer – tale, musik og soundscapes eller lydmiljøer. Det midterste afsnit diskuterer den tidligere forsknings relevans for forskellige slags medier; artiklen skelner her mellem tre grader af medier. Og artiklens sidste del samler de tværfaglige indsigter i en dagsorden for (meget mere medieforskning om lyd som kommunikation.
Lyd som kommunikation. En tværfaglig forskningsoversigt og en dagsorden for medieforskningen
Directory of Open Access Journals (Sweden)
Klaus Bruhn Jensen
2006-06-01
Full Text Available Lyden har ikke noget videnskabeligt hjem – i modsætning til f.eks. faste og levende billeder, der traditionelt er blevet studeret af henholdsvis kunsthistorien og filmvidenskaben. Denne artikel giver en oversigt over de mange, meget forskellige slags forskning om lyd. Formålet er at stimulere og kvalificere mere medieforskning om lyd. Hovedvægten ligger på lyd som kommunikation i og omkring medierne – som en kilde til mening og en ressource i social og kulturel handling, snarere end på lyd i et teknisk eller akustisk perspektiv (se f.eks. Plomp, 2002. Første del af artiklen gennemgår forskellige humanistiske og samfundsvidenskabelige tilgange til lydens tre grundformer – tale, musik og soundscapes eller lydmiljøer. Det midterste afsnit diskuterer den tidligere forsknings relevans for forskellige slags medier; artiklen skelner her mellem tre grader af medier. Og artiklens sidste del samler de tværfaglige indsigter i en dagsorden for (meget mere medieforskning om lyd som kommunikation.
A variational principle for the Hausdorff dimension of fractal sets
DEFF Research Database (Denmark)
Olsen, Lars; Cutler, Colleen D.
1994-01-01
Matematik, fraktal (fractal), Hausdorff dimension, Renyi dimension, pakke dimension (packing dimension)......Matematik, fraktal (fractal), Hausdorff dimension, Renyi dimension, pakke dimension (packing dimension)...
For det kommende i det tidlige
DEFF Research Database (Denmark)
Grønbæk, Niels
2008-01-01
. Man kan sige at fortroligheden er enten medieret - fx gennem sprog, skrift, håndtering af værktøj osv., eller opstår i og med de stabile formationer - som fx det vi i fremskredne stadier kender som vaner. Vaner kan opfattes som stabile formationer, som mønstre; men det kan de 'medierede fortroligheder......' også, hvis man i stedet for at lægge vægten på værktøjet eller mediet, lægger den på teknikken - og dermed på en praksis eller en kunnen. I min afhandling fører det til et radikalt materiale-begreb: 'egentligt' materiale kan ikke være nærværende - nærværende véd vi ikke andet om det end at der er noget...... Udgangspunktet for afhandlingens kulturkritiske dimension, er dén påstand eller dobbelt-tese at: 1) kulturen (for tiden) foretrækker visse teknikker frem for andre. Her er min overordnede påstand at epistemet er kendetegnet af en orientering mod tegnene - hvilket egentlig vil sige: mod sit kulturelle indre. Et...
DEFF Research Database (Denmark)
Bech, Henning; Necef, Mehmet Ümit
Igennem de seneste årtier er det blevet almindeligt at tale om, at der er en udbredt racisme i Danmark. Påstande om danskernes racisme, fremmedhad og diskrimination optræder dagligt i offentligheden og i medierne, og der henvises ofte til, hvad ’forskerne’ og de ’videnskabelige undersøgelser’ siger...... om emnet. Der kan da næppe heller være tvivl om, at der forekommer racistiske holdninger hos nogle danskere. Men er problemet så stort, som det gøres til i den offentlige debat? Bogen ønsker at afklare, hvorvidt der er videnskabelig dokumentation for påstandene om danskernes racisme. Den går i dybden...... med en række forskeres og eksperters udtalelser på området og præsenterer en grundig analyse af deres fremstilling af dansk racisme i forhold til emner som kultur, seksualitet, kriminalitet og arbejdsmarked....
Den sproglige leg er super fly
DEFF Research Database (Denmark)
Just, Sine Nørholm
2013-01-01
Man kan rappe om alt. I hvert fald hvis man er Marvelous Mosell. I spændingsfeltet mellem fiktion og virkelighed skaber Mosell sin persona i et forjættende 80' er-univers der på en og samme tid er vildt overdrevet og helt autentisk.......Man kan rappe om alt. I hvert fald hvis man er Marvelous Mosell. I spændingsfeltet mellem fiktion og virkelighed skaber Mosell sin persona i et forjættende 80' er-univers der på en og samme tid er vildt overdrevet og helt autentisk....
Cao, Pengfei; Renna, Luciana; Stefano, Giovanni; Brandizzi, Federica
2016-12-05
The endoplasmic reticulum (ER) is an essential organelle that spreads throughout the cytoplasm as one interconnected network of narrow tubules and dilated cisternae that enclose a single lumen. The ER network undergoes extensive remodeling, which critically depends on membrane-cytoskeleton interactions [1]. In plants, the ER is also highly mobile, and its streaming contributes significantly to the movement of other organelles [2, 3]. The remodeling and motility of the plant ER rely mainly on actin [4] and to a minor extent on microtubules [5]. Although a three-way interaction between the ER, cytosolic myosin-XI, and F-actin mediates the plant ER streaming [6], the mechanisms underlying stable interaction of the ER membrane with actin are unknown. Early electron microscopy studies suggested a direct attachment of the plant ER with actin filaments [7, 8], but it is plausible that yet-unknown proteins facilitate anchoring of the ER membrane with the cytoskeleton. We demonstrate here that SYP73, a member of the plant Syp7 subgroup of SNARE proteins [9] containing actin-binding domains, is a novel ER membrane-associated actin-binding protein. We show that overexpression of SYP73 causes a striking rearrangement of the ER over actin and that, similar to mutations of myosin-XI [4, 10, 11], loss of SYP73 reduces ER streaming and affects overall ER network morphology and plant growth. We propose a model for plant ER remodeling whereby the dynamic rearrangement and streaming of the ER network depend on the propelling action of myosin-XI over actin coupled with a SYP73-mediated bridging, which dynamically anchors the ER membrane with actin filaments. Copyright © 2016 Elsevier Ltd. All rights reserved.
DEFF Research Database (Denmark)
Prebensen, Henrik
2006-01-01
Sprogvidenskab, matematisk lingvistik, matematik, humaniora, sprogform, Saussure, Frege, Russel, Reichenbach, Chomsky, formalisme, funktionalisme......Sprogvidenskab, matematisk lingvistik, matematik, humaniora, sprogform, Saussure, Frege, Russel, Reichenbach, Chomsky, formalisme, funktionalisme...
Site of Er ions in silica layers codoped with Si nanoclusters and Er
International Nuclear Information System (INIS)
Pellegrino, P.; Garrido, B.; Arbiol, J.; Garcia, C.; Lebour, Y.; Morante, J.R.
2006-01-01
Silica layers implanted with Si and Er ions to various doses and annealed at 950 deg. C have been investigated by means of energy-filtered transmission electron microscopy (EFTEM) and high annular angle dark field (HAADF). EFTEM analysis reveals Si nanoclusters (Si-nc) with an average size around 3 nm for high Si content (15 at. %) whereas no clusters can be imaged for the lowest Si excess (5 at. %). Raman scattering supports that amorphous Si precipitates are present in all the samples. Moreover, the filtered images show that Er ions appear preferentially located outside the Si-nc. HAADF analysis confirms that the Er atoms form agglomerations of 5-10 nm size when the Er concentration exceeds 1x10 20 cm -3 . This observation correlates well with the reduction of the Er population excitable by Si nanoclusters, in the best case corresponding to 10% of the total. A suitable tuning of the annealing drastically reduces this deleterious effect
Directory of Open Access Journals (Sweden)
G. A. Sobral
2015-01-01
Full Text Available Fluorescence intensity ratio (FIR technique, based on the thermal coupling of H11/22 and S3/24 energy levels of erbium ions, was used to study the optical heating behavior of rare earth doped yttrium oxide nanophosphors (Y2O3:Er3+, Y2O3:Er3+-Eu3+, Y2O3:Er3+-Tb3+, and Y2O3:Er3+-Eu3+-Tb3+ synthesized via PVA-assisted sol-gel route. The samples were optically heated by an 800 nm CW diode laser, while the upconverted green emissions were used to measure their temperatures in real time. The experimental results indicate that the studied nanoparticles are promising candidates to applications such as photothermal treatments and hyperthermia.
DEFF Research Database (Denmark)
van der Meijden, Peter Alexander
2008-01-01
"Fluxus-øer" er en introduktion til Fluxus med udgangspunkt i den tyske galleri-ejer René Blocks samling, som udstillingen "Food for Thought" i Sukkerfabrikken i Stege (Møn) præsenterede et udvalg af. Artiklen beskriver Fluxus som et heterotopi som beskrevet af Michel Foucault i "Of Other Spaces"...
DEFF Research Database (Denmark)
Knakkergaard, Martin
2015-01-01
med dette talpar omtyder vi alt, hvad der lader sig omtyde, til tabeller i en ustoppelig bevægelse, som efterlader det omtydede til glemsel og nostalgi. Afhængig af hvordan vi anskuer disse tabeller, i det rene Aristoteliske perspektiv eller i Heideggers mere spekulative optik, er det enten causa...... finalis eller causa efficiens, som tabellerne fremstiller for os, men hvad blev der af causa materialis og causa formalis undervejs? Og at producere betyder netop at stille frem, at fremstille - dette vægter ifølge sagens natur det 'stillads' - den teknik eller teknologi - gennem hvilket noget stilles...
Shaheen, Alaa
2018-05-05
The unfolded protein response (UPR) is an adaptive cellular response that aims to relieve endoplasmic reticulum (ER) stress via several mechanisms, including inhibition of protein synthesis and enhancement of protein folding and degradation. There is a controversy over the effect of the UPR on ER protein export. While some investigators suggested that ER export is inhibited during ER stress, others suggested the opposite. In this article, their conflicting studies are analyzed and compared in attempt to solve this controversy. The UPR appears indeed to enhance ER export, possibly via multiple mechanisms. However, another factor, which is the integrity of the folding machinery/environment inside ER, determines whether ER export will appear increased or decreased during experimentation. Also, different methods of stress induction appear to have different effects on ER export. Thus, improvement of ER export may represent a new mechanism by which the UPR alleviates ER stress. This may help researchers to understand how the UPR works inside cells and how to manipulate it to alter cell fate during stress, either to promote cell survival or death. This may open up new approaches for the treatment of ER stress-related diseases.
DEFF Research Database (Denmark)
Schilling, Benedicte; Jacobsen, Claus Haugaard; Nielsen, Jan
2010-01-01
Kontrol, kontrakt og kontekst er supervisionens tre k'er. Men hvad er supervision i det hele taget for en størrelse, der spillerså central en rolle for den psykologfaglige profession?......Kontrol, kontrakt og kontekst er supervisionens tre k'er. Men hvad er supervision i det hele taget for en størrelse, der spillerså central en rolle for den psykologfaglige profession?...
Singapores uddannelsessystem og læringsmiljø
DEFF Research Database (Denmark)
Caeli, Elisa Nadire; Chan, Michael
2018-01-01
I uddannelsesverdenen er Singapore kendt som den nation, der rangerer højest ud af de 72 nationer i PISA’s undersøgelse af elevers præstationer på fagområderne naturvidenskab, matematik og læsning. Det har i danske medier skabt fængende slaglinjer som ”I Singapore er de bare bedst” (Berlingske......, 2016), der indikerer, at Singapores uddannelsessystem må være bedre end det danske, når de formår gang på gang at stryge til tops i faglige test, mens vi danderer den længere nede ad rangstigen. Så enkel er forklaringen imidlertid ikke, mener denne artikels forfattere. Singapore anses ganske vist som...... uddannelse. Denne artikel har til formål at give indsigt i Singapores uddannelsessystem og læringsmiljø og singaporeanske børns (skole)liv med henblik på at forstå, hvad to nationer som Danmark og Singapore kan lære af hinanden og at eliminere slaglinjer som den nævnte ved at beskrive de mange faktorer, der...
Coronavirus infection, ER stress and Apoptosis
Directory of Open Access Journals (Sweden)
TO SING eFUNG
2014-06-01
Full Text Available The replication of coronavirus, a family of important animal and human pathogens, is closely associated with the cellular membrane compartments, especially the endoplasmic reticulum (ER. Coronavirus infection of cultured cells was previously shown to cause ER stress and induce the unfolded protein response (UPR, a process that aims to restore the ER homeostasis by global translation shutdown and increasing the ER folding capacity. However under prolonged ER stress, UPR can also induce apoptotic cell death. Accumulating evidence from recent studies has shown that induction of ER stress and UPR may constitute a major aspect of coronavirus-host interaction. Activation of the three branches of UPR modulates a wide variety of signaling pathways, such as mitogen-activated protein (MAP kinases activation, autophagy, apoptosis and innate immune response. ER stress and UPR activation may therefore contribute significantly to the viral replication and pathogenesis during coronavirus infection. In this review, we summarize current knowledge on coronavirus-induced ER stress and UPR activation, with emphasis on their cross-talking to apoptotic signaling.
DEFF Research Database (Denmark)
Poulfelt, Flemming
2015-01-01
HR: Er der behov for nytænkning i HR-land? Artikler i Harvard Business Review - bakket op af en dansk undersøgelse - konkluderer, at HR stadig mangler gennemslagskraft i virksomhederne. Er HR ude i tovene? ... For i undersøgelsen "Ny Dansk Ledelse" (maj 2015), som er baseret på danske lederes...
DEFF Research Database (Denmark)
Pedersern, Birger
2010-01-01
Forskningen i fødevarer har fået et potent redskab i hånden. Metabolomics er vejen frem, mener professor Søren Balling Engelsen fra Københavns Universitet......Forskningen i fødevarer har fået et potent redskab i hånden. Metabolomics er vejen frem, mener professor Søren Balling Engelsen fra Københavns Universitet...
DEFF Research Database (Denmark)
Helms, Niels Henrik
2008-01-01
Brugerdreven innovation er blevet svaret på mange af de udfordringer, som vores moderne samfund står overfor.Det er skrevet ind i såvel regeringsgrundlaget som i de forskellige tiltag, som skal ruste Danmark i forhold til globaliseringen. Vi har ifølge argumentationen her enrække særlige forudsæt....... Udgivelsesdato: marts 2008...
DEFF Research Database (Denmark)
Jensen, J. P.; Søndergaard, M.; Jeppesen, E.
styrke det fagli-ge grundlag for de mil-jøpolitiske prioriteringer og beslut-ninger. En væsentlig del af denne opgave er overvågning af miljø og natur. Det er derfor et naturligt led i Danmarks Miljø-undersø-gelsers opgave at forestå den landsdækkende rapportering af overvågnings-program-met inden...
DEFF Research Database (Denmark)
Andersson, Lasse
2014-01-01
afhængig af Frank Underwood fra serien House of Cards på den fremadstormende TV-streamingstjenesten Netflix. Jeg har opdaget et nyt internetbaseret datingforhold. Et surrealt, fedt miks af det kyniske og joviale personificeret i karakteren Frank Underwood, som er helt igennem ubehagelig, men fantastisk...... spillet af Kevin Spacey. Og tak til Spacey der for en tid har forladt teateret ’The Old Vic’ i London for at begejstre mig. Der er generelt to årsager til mine FRANKofile tilbøjeligheder. For det første er Netflix’s remake af den tyve år gamle BBC serie House of Cards efter min menig et stykke tv...... anden grund, til at jeg er blevet Frankofil, er, at jeg ikke skal sidde og vente på næste søndag efter søndag efter søndag for at få lov at se næste afsnit. Netflix lagde alle tretten timer af sæson 2 ud på nettet. Jeg afgør selv, hvornår jeg skal have mere Frank! Men på trods af mit narkomanlignende...
DEFF Research Database (Denmark)
Gundelach, Peter; Nørregård-Nielsen, Esther C.
2002-01-01
Hvornår er man ung, og hvornår er man voksen? Er der forskelle i befolkningens værdier i forhold til arbejde og politik, når det undersøges ud fra henholdsvis et alders- eller generationsperspektiv? Baseret på data fra den danske del af den internationale værdiundersøgelse vises at der er så store...
DEFF Research Database (Denmark)
Jensen, J. P.; Søndergaard, M.; Jeppesen, E.
små cladoceer og hjuldyr, og især er maksimumsforekom-sterne af calanoide vandlopper og de små og store cladoceer og daf-nier gået tilbage. Den gennemsnitlige biomasse af dafnier er derimod øget især p.g.a. stigning i de 25 % af søerne med størst forekomster. Dyreplanktons græsning Betragtet under et...
The role of the AR/ER ratio in ER-positive breast cancer patients.
Rangel, Nelson; Rondon-Lagos, Milena; Annaratone, Laura; Osella-Abate, Simona; Metovic, Jasna; Mano, Maria Piera; Bertero, Luca; Cassoni, Paola; Sapino, Anna; Castellano, Isabella
2018-03-01
The significance of androgen receptor (AR) in breast cancer (BC) management is not fully defined, and it is still ambiguous how the level of AR expression influences oestrogen receptor-positive (ER+) tumours. The aim of the present study was to analyse the prognostic impact of AR/ER ratio, evaluated by immunohistochemistry (IHC), correlating this value with clinical, pathological and molecular characteristics. We retrospectively selected a cohort of 402 ER+BC patients. On each tumour, IHC analyses for AR, ER, PgR, HER2 and Ki67 were performed and AR+ cases were used to calculate the AR/ER value. A cut-off of ≥2 was selected using receiver-operating characteristic (ROC) curve analyses. RNA from 19 cases with AR/ER≥2 was extracted and used for Prosigna-PAM50 assays. Tumours with AR/ER≥2 (6%) showed more frequent metastatic lymph nodes, larger size, higher histological grade and lower PgR levels than cases with AR/ERAR/ER≥2 had worse disease-free interval (DFI) and disease-specific survival (DSS) (hazard ratios (HR) = 4.96 for DFI and HR = 8.69 for DSS, both P ≤ 0.004). According to the Prosigna-PAM50 assay, 63% (12/19) of these cases resulted in intermediate or high risk of recurrence categories. Additionally, although all samples were positive for ER assessed by IHC, the molecular test assigned 47.4% (9/19) of BCs to intrinsic non-luminal subtypes. In conclusion, the AR/ER ratio ≥2 identifies a subgroup of patients with aggressive biological features and may represent an additional independent marker of worse BC prognosis. Moreover, the Prosigna-PAM50 results indicate that a significant number of cases with AR/ER≥2 could be non-luminal tumours. © 2018 Society for Endocrinology.
West, Diana C.; Pan, Deng; Tonsing-Carter, Eva Y.; Hernandez, Kyle M.; Pierce, Charles F.; Styke, Sarah C.; Bowie, Kathleen R.; Garcia, Tzintzuni I.; Kocherginsky, Masha; Conzen, Suzanne D.
2016-01-01
In estrogen receptor (ER)-negative breast cancer (BC), high tumor glucocorticoid receptor (GR) expression has been associated with a relatively poor outcome. In contrast, using a meta-analysis of several genomic datasets, here we find that tumor GR mRNA expression is associated with improved ER+ relapse-free survival (RFS) (independently of progesterone receptor (PR) expression). To understand the mechanism by which GR expression is associated with a better ER+ BC outcome, the global effect of GR-mediated transcriptional activation in ER+ BC cells was studied. Analysis of GR chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) in ER+/GR+ MCF-7 cells revealed that upon co-activation of GR and ER, GR chromatin association became enriched at proximal promoter regions. Furthermore, following ER activation, increased GR chromatin association was observed at ER, FOXO, and AP1 response elements. In addition, ER associated with GR response elements, suggesting that ER and GR interact in a complex. Co-activation of GR and ER resulted in increased expression (relative to ER activation alone) of transcripts that encode proteins promoting cellular differentiation (e.g. KDM4B, VDR) and inhibiting the Wnt-signaling pathway (IGFBP4). Finally, expression of these individual pro-differentiation genes was associated with significantly improved RFS in ER+ BC patients. Together, these data suggest that the co-expression and subsequent activity of tumor cell GR and ER contribute to the less aggressive natural history of early-stage BC by coordinating the altered expression of genes favoring differentiation. Implications The interaction between estrogen and glucocorticoid receptor activity highlights the importance of context-dependent nuclear receptor function in cancer. PMID:27141101
Endoplasmic Reticulum (ER Stress and Endocrine Disorders
Directory of Open Access Journals (Sweden)
Daisuke Ariyasu
2017-02-01
Full Text Available The endoplasmic reticulum (ER is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR, which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI, Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2 are discussed in this article.
Endoplasmic Reticulum (ER) Stress and Endocrine Disorders
Ariyasu, Daisuke; Yoshida, Hiderou; Hasegawa, Yukihiro
2017-01-01
The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article. PMID:28208663
Akiyama, Y.; Heyde, K.; Arima, A.; Yoshinaga, N.
1986-05-01
Extending the interacting boson model by incorporating besides s and d, also the g-boson, we can describe the population of positive parity states of 168Er in the 166Er(t,P) 168Er reaction rather well. In particular, the excitation of I,Kπi = 4,3 +1; 2,2 +2; 0,0 +3 and 0,0 +4 states is much improved over the sd-IBM approach.
DEFF Research Database (Denmark)
Rennison, Betina Wolfgang
2017-01-01
Ledere skal i dag selv skabe deres eget rum til ledelse, men hvad er med til at sætte det, hvilke betingelser og udfordringer er der, og hvordan kan lederne skabe sig selv i et hav af forventninger? Dette katalog inviterer til refleksion herom....
Effect of Er3+ Concentration on Upconversion in Hexagonal-Phase NaYF4:Er3+ Nanocrystals
International Nuclear Information System (INIS)
Luo, X J; Yuminami, R; Sakurai, T; Akimoto, K
2013-01-01
A facile synthesis method was developed to produce hexagonal-phase of NaYF 4 nanocrystals (NCs) doped with Er 3+ in different concentration, which showed upconversion (UC) emission from infrared to visible spectral region. This proposed method is simple and less toxic compared with generally used method so far. It was found that up-conversion emission spectra of NaYF 4 :Er 3+ NCs, excited at 1550 nm, included four peaks at about 980 nm, 800 nm, 660 nm and 540 nm. The effect of Er 3+ concentration on UC in β-phase NaYF 4 :Er 3+ NCs were discussed based on the excitation power dependence. The optimum Er 3+ concentration for 2-step and 3-step UC was found to be around 10∼30%.
Nielsen, Jon Magne
2006-01-01
Denne oppgaven ser på bruken av elektronisk ID i statlige etater i Norge i dag. Det ses spesielt på om bruken av tekologien PKI er en god løsning på etatenes behov på dette området. Som utgangspunkt for analysen er det sett spesielt på to statlige etater. Disse etatenes behov og bruk av elektronisk ID generelt og PKI spesielt blir undersøkt. Det er videre gjort rede for hvilke lover, forskrifter og andre førende dokumenter som danner de formelle rammebetingelsene for etaters bruk av PKI. ...
DEFF Research Database (Denmark)
Rydén, Pernille; Ringberg, Torsten; Wilke, Ricky
En forskningsrapport fra CBS om danske lederes opfattelse af sociale medier i detail- og servicebranchen. Rapporten er udarbejdet i regi af Service Platform.......En forskningsrapport fra CBS om danske lederes opfattelse af sociale medier i detail- og servicebranchen. Rapporten er udarbejdet i regi af Service Platform....
DEFF Research Database (Denmark)
Harste, Gorm
2009-01-01
, at innovation af innovationen forsøges gennemført på en måde, hvor tiden kræves at forholde sig til sin egen tidslighed i form af fremtid, nutid, fortid og ikke mindst i form af samtidighed. I tiden skal vi iagttage, hvordan vi iagttager tiden. Vi dobbelt-koder tiden på samme måde, som forskning forsker i...... organisationssystemerne. De to typer systemer kan noget helt bestemt med fænomenet tid. De kan synkronisere. Analyseres organisationssystemer ser vi, imidlertid at innovation kræver ro. Stærkt innovative systemer er militærsystemet og kunstsystemet, der også inddrages, og hvor vi ser paradokset mellem innovation og...... involution. Tid er med et medium og ikke et lufttomt rum. Tid er end ikke en gasart, men udgør et solidt fluidum, som samfundet bader i og flyder i, konstant i bevægelse. Reformer forudsætter former, og innovation forudsætter involution. Kun sådan muliggøres evolution....
Directory of Open Access Journals (Sweden)
Yaşar Akkan
2017-12-01
Full Text Available The aim of this study is to investigate the generalizations created by pre-service elementary mathematic teachers, to explore the justifications predicted for their generalizations, and to determine any relationships between generalization and justification. We used phenomenology design from qualitative research methods in the study. The study was conducted by the 4th grade students/pre-service teachers who are studying in a department of Elementary Mathematics Teaching at a university located in the Eastern Black Sea region. Data collection tools are linear and quadratic pattern problems which are prepared with the support of literature and teaching staff and in which different solution strategies and justification types can be produced. Interviews were analyzed using the descriptive analysis technique within the conceptual framework of the research. The results show that the most common type of strategy used by pre-service teachers was functional strategy, contextual, recursive, guess-check and mixed strategies. While many of the pre-service teachers have justified their verification by numerical control, pre-service teachers who have justified through explanation and external knowledge sources have also been identified. [Bu çalışmanın amacı, ilköğretim matematik öğretmeni adaylarının farklı örüntü problemleri ile ilgili genelleme stratejilerini incelemek, genellemelerinin altında yatan gerekçelendirmeleri keşfetmek ve genelleme ile gerekçelendirmeleri arasındaki ilişkileri belirlemektir. Çalışma nitel araştırma desenlerinden olgubilim modeline göre tasarlanmıştır. Çalışma, Doğu Karadeniz Bölgesindeki bir üniversitenin İlköğretim Matematik Öğretmenliği programında öğrenim gören 4. sınıf öğretmen adayları ile yürütülmüştür. Veri toplama araçları, hem literatür hem de öğretim üyesi desteğiyle hazırlanan ve farklı çözüm stratejilerinin ve gerekçelendirme çeşitlerinin
Anjana, R.; Jayaraj, M. K.; Yadav, A. K.; Jha, S. N.; Bhattacharyya, D.
2018-04-01
The local structure around Er and Yb centre in ZnO favouring upconversion luminescence was studied using EXAFS (Extended X-ray absorption fine structure spectroscopy). Due to the ionic radii difference between Zn and Er, Yb ions, the dopants cannot replace Zn in the ZnO lattice properly. Er2O3 and Yb2O3 impurity phases are formed at the grain boundaries of ZnO. It is found that the local structure around the Er centre in ZnO is modified on annealing in air. The symmetry around both erbium and ytterbium reduces with increase in annealing temperature. Symmetry reduction will favour the intra-4f transition and the energy transitions causing upconversion luminescence. By fitting the EXAFS data with theoretically simulated data, it is found that the Er centre forms a local structure similar to C4ν symmetry which is a distorted octahedron. On annealing the sample to 1200 °C, all the erbium centres are transformed to C4ν symmetry causing enhanced upconversion emission. Yb centre has also been modified on annealing. The decrease in co-ordination number with annealing temperature will decrease the symmetry and increase the near infrared absorption cross section. The decrease in symmetry around both the erbium and ytterbium centre and formation of C4ν symmetry around Er centre is the reason behind the activation of upconversion luminescence with high temperature annealing in both Er doped and Er, Yb co-doped ZnO samples. The study will be useful for the synthesis of high efficiency upconversion materials.
International Nuclear Information System (INIS)
Mera, Kentaro; Kawahara, Ko-ichi; Tada, Ko-ichi; Kawai, Kazuhiro; Hashiguchi, Teruto; Maruyama, Ikuro; Kanekura, Takuro
2010-01-01
Proteins are folded properly in the endoplasmic reticulum (ER). Various stress such as hypoxia, ischemia and starvation interfere with the ER function, causing ER stress, which is defined by the accumulation of unfolded protein (UP) in the ER. ER stress is prevented by the UP response (UPR) and ER-associated degradation (ERAD). These signaling pathways are activated by three major ER molecules, ATF6, IRE-1 and PERK. Using HaCaT cells, we investigated ER signaling in human keratinocytes irradiated by environmental doses of ultraviolet B (UVB). The expression of Ero1-Lα, an upstream signaling molecule of ER stress, decreased at 1-4 h after 10 mJ/cm 2 irradiation, indicating that the environmental dose of UVB-induced ER stress in HaCaT cells, without growth retardation. Furthermore, expression of intact ATF6 was decreased and it was translocated to the nuclei. The expression of XBP-1, a downstream molecule of IRE-1, which is an ER chaperone whose expression is regulated by XBP-1, and UP ubiquitination were induced by 10 mJ/cm 2 UVB at 4 h. PERK, which regulates apoptosis, was not phosphorylated. Our results demonstrate that UVB irradiation generates UP in HaCaT cells and that the UPR and ERAD systems are activated to protect cells from UVB-induced ER stress. This is the first report to show ER signaling in UVB-irradiated keratinocytes.
ER Stress: A Therapeutic Target in Rheumatoid Arthritis?
Rahmati, Marveh; Moosavi, Mohammad Amin; McDermott, Michael F
2018-04-22
Diverse physiological and pathological conditions that impact on protein folding of the endoplasmic reticulum (ER) cause ER stress. The unfolded protein response (UPR) and the ER-associated degradation (ERAD) pathway are activated to cope with ER stress. In rheumatoid arthritis (RA), inflammation and ER stress work in parallel by driving inflammatory cells to release cytokines that induce chronic ER stress pathways. This chronic ER stress may contribute to the pathogenesis of RA through synoviocyte proliferation and proinflammatory cytokine production. Therefore, ER stress pathways and their constituent elements are attractive targets for RA drug development. In this review, we integrate current knowledge of the contribution of ER stress to the overall pathogenesis of RA, and suggest some therapeutic implications of these discoveries. Copyright © 2018 Elsevier Ltd. All rights reserved.
Fremtidens undervisningsmiljøer
DEFF Research Database (Denmark)
2013-01-01
Som oplægget til dette temanummer af LOM også indikerede, så sætter vi fokus på fremtidens undervisningsmiljøer på universiteter og UCer. Fremtidens undervisningsmiljøer har mange facetter, hvilket samlingen af artikler også illustrerer. “Fremtidens Undervisningsmiljø” handler om eksisterende erf...
Explaining Dimensions of Middle School Mathematics Teachers’ Use of Textbooks
Directory of Open Access Journals (Sweden)
Meric ÖZGELDİ
2012-12-01
Full Text Available Abstract The purpose of the study was to describe middle school mathematics teachers’ use of textbooks. For this purpose, the Use of Mathematics Textbooks Questionnaire was distributed to 531 middle school mathematics teachers. The results of the study showed that teachers used the student edition textbook during the class and prior to class; and mostly read it for the topic, but rarely for problems and examples. Teachers frequently selected questions from the workbook that were not included in the student edition textbook. They frequently used questions in the workbook similar to the ones in the high school entrance exam questions. They used the teacher edition textbook to read the curriculum objectives and to prepare for the class but they very rarely tended to look up the answers of the questions from the teacher edition textbook. They frequently used auxiliary books to select questions that were not included in the student edition textbook. Key words: mathematics textbooks, mathematics teachers’ use of textbooks, middle school Özet Bu çalışmanın amacı, ilköğretim matematik öğretmenlerinin ders kitabı kullanımlarını tanımlamaktır. Bu amaçla, Matematik Öğretmenlerinin Ders Kitabı Kullanım Ölçeği, 531 ilköğretim matematik öğretmenine dağıtılmıştır. Çalışmanın sonuçları göstermektedir ki, öğretmenler ders kitabını sıklıkla derse hazırlık sürecinde ve ders sırasında kullanırken nadiren problemler ve örnekler için kullanmaktadır. Öğretmenler özellikle konunun günlük hayatla ilişkilendirilmesi, diğer derslerle bağlantı kurulması, konu sırasının takibi için ders kitabından faydalanmaktadır. Öğretmenler, çoğunlukla çalışma kitabında bulunan merkezi sınav sorularına benzer soruları kullanmaktadır. Öğretmen kılavuzunu ise kazanımlara bakmak ve derse hazırlık yapmak için kullanmaktadır. Bununla beraber, öğretmenler yardımcı kitapları merkezi s
Suppression of concentration quenching of Er-related luminescence in Er-doped GaN
International Nuclear Information System (INIS)
Chen Shaoqiang; Tomita, Shigeo; Kudo, Hiroshi; Akimoto, Katsuhiro; Dierre, Benjamin; Lee, Woong; Sekiguchi, Takashi
2010-01-01
Erbium-doped GaN with different doping concentrations were grown by ammonia-source molecular beam epitaxy. The intra-4f-shell transitions related green luminescence were observed by both photoluminescence (PL) and cathodoluminescence (CL) measurements. It was found that concentration quenching of Er-related luminescence was observed in PL measurements while not in CL measurements. The different excitation and relaxation processes are suggested as the cause of the concentration quenching characteristics between PL and CL. The strong Er-related CL intensity in highly doped GaN demonstrates that high energy excitation is a promising approach to suppress the concentration quenching in Er-doped GaN.
Directory of Open Access Journals (Sweden)
Niels Hannibal
2014-06-01
Full Text Available Denne artikel omhandler musikterapiens særlige kompetencer og består af to dele. I første del præsenteres det særlige ved musikterapi i et kort og overordnet perspektiv i forhold til de elementer musikterapi indeholder såsom interventionsformer, udbytte, anvendelse, dokumentation, teori, behandlingskontekst. Anden del udfolder kliniske eksempler på det som overordnet beskrives i første del. Det problematiseres, at det specifikke og non-specifikke ikke så let kan adskilles, men samtidig præsenteres også forfatternes holdning: at musikterapi besidder ²noget² som er særligt og som giver faget en identitet.
Self-diffusion of Er and Hf inpure and HfO2-doped polycrystalline Er2O3
International Nuclear Information System (INIS)
Scheidecker, R.W.
1979-01-01
Using a tracer technique, self-diffusion of Er and Hf was measured over the approximate temperature interval of 1600 to 1970 0 C in pure and HfO 2 -doped polycryatalline Er 2 O 3 . Up to about 10 m/o HfO 2 dopant level, the Er self-diffusion coefficients followed a relationship based on cation vacancies. Above 10 m/o HfO 2 , deviation from this relationship occurred, apparently due to clustering of cation vacancies and oxygen interstitials around the dopant hafnia ion. The activation energy for the self-diffusion of Er in pure Er 2 O 3 was 82.2 Kcal/mole and increased with the HfO 2 dopant level present. Self-diffusion of Hf was measured in pure Er 2 O 3 having two impurity levels, and a separation of the grain boundary. The volume diffusion of Hf showed both extrinsic and intrinsic behavior with the transition temperature increasing with the impurity level present in Er 2 O 3 . The activation energy for Hf volume diffusion in the intrinsic region was high, i.e. 235 -+ 9.5 Kcal/mole. The grain boundary diffusion was apparently extrinsic over the entire temperature interval Very low Hf self diffusion rates were found in both pure and HfO 2 doped Er 2 O 3 compositions. Despite a clustering effect, the HfO 2 dopant increased the Hf volume diffusion coefficients
Directory of Open Access Journals (Sweden)
Tomohisa Mori
Full Text Available The membrane of the endoplasmic reticulum (ER of a cell forms contacts directly with mitochondria whereby the contact is referred to as the mitochondrion-associated ER membrane or the MAM. Here we found that the MAM regulates cellular survival via an MAM-residing ER chaperone the sigma-1 receptor (Sig-1R in that the Sig-1R chaperones the ER stress sensor IRE1 to facilitate inter-organelle signaling for survival. IRE1 is found in this study to be enriched at the MAM in CHO cells. We found that IRE1 is stabilized at the MAM by Sig-1Rs when cells are under ER stress. Sig-1Rs stabilize IRE1 and thus allow for conformationally correct IRE1 to dimerize into the long-lasting, activated endonuclease. The IRE1 at the MAM also responds to reactive oxygen species derived from mitochondria. Therefore, the ER-mitochondrion interface serves as an important subcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria, ER, and nucleus.
Mori, Tomohisa; Hayashi, Teruo; Hayashi, Eri; Su, Tsung-Ping
2013-01-01
The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with mitochondria whereby the contact is referred to as the mitochondrion-associated ER membrane or the MAM. Here we found that the MAM regulates cellular survival via an MAM-residing ER chaperone the sigma-1 receptor (Sig-1R) in that the Sig-1R chaperones the ER stress sensor IRE1 to facilitate inter-organelle signaling for survival. IRE1 is found in this study to be enriched at the MAM in CHO cells. We found that IRE1 is stabilized at the MAM by Sig-1Rs when cells are under ER stress. Sig-1Rs stabilize IRE1 and thus allow for conformationally correct IRE1 to dimerize into the long-lasting, activated endonuclease. The IRE1 at the MAM also responds to reactive oxygen species derived from mitochondria. Therefore, the ER-mitochondrion interface serves as an important subcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria, ER, and nucleus.
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
Bravo, Roberto; Gutierrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodriguez, Andrea E.; Pedrozo, Zully; Chiong, Mario; Parra, Valentina; Quest, Andrew F.G.; Rothermel, Beverly A.; Lavandero, Sergio
2014-01-01
Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged cells. The molecular mechanisms responsible for execution of the cell death program are relatively well characterized, but the metabolic events taking place during the adaptive phase of ER stress remain largely undefined. Here we discuss emerging evidence regarding the metabolic changes that occur during the onset of ER stress and how ER influences mitochondrial function through mechanisms involving calcium transfer, thereby facilitating cellular adaptation. Finally, we highlight how dysregulation of ER–mitochondrial calcium homeostasis during prolonged ER stress is emerging as a novel mechanism implicated in the onset of metabolic disorders. PMID:22064245
DEFF Research Database (Denmark)
Nielsen, Rikke Kristine
2013-01-01
Færdigheder: Oftest er lederne langtfra de første til at kaste sig over ny teknologi. It-kundskaberne på chefgangen trænger til en opgradering.......Færdigheder: Oftest er lederne langtfra de første til at kaste sig over ny teknologi. It-kundskaberne på chefgangen trænger til en opgradering....
Dannelse som basis for udvikling af moderne matematikundervisning
Directory of Open Access Journals (Sweden)
Julie Marie Isager
2013-09-01
Full Text Available I denne artikel omtales ambitionerne, opbygningen og resultaterne af et nyt pædagogisk projekt om forbedring af undervisningen i matematik for førsteårsstuderende på Økonomisk Institut ved Københavns Universitet. Initiativet er siden efteråret 2007 blevet udbygget og har hentet væsentlige elementer fra klassisk Kant-Humboldtsk dannelsesteori og moderne universitetspædagogik. Efter at initiativet er iværksat, har de studerende ændret studieadfærd: De er blevet mere aktive og engagerede, og eksamensresultaterne er væsentligt forbedret. Initiativet er ikke fagspecifikt, så andre fag vil kunne lade sig inspirere af vores tanker og metoder. This article considers the ambitions, design, and results of a new education project intended to improve the teaching of mathematics to first-year students in the Department of Economics at the University of Copenhagen. The initiative, which has been in development since 2007, was inspired by the classical Kantian-Humboldtian theory of Bildung and by modern theories of tertiary teaching methodology. Observations made following the intervention reveal that the students have changed their behaviour; they have become increasingly active and engaged, and the examination results have improved considerably. The initiative is not subject specific and other fields of study may find inspiration in our thoughts and methods.
Synthesis of Er and Er : Yb doped sol–gel derived silica glass and ...
Indian Academy of Sciences (India)
Unknown
Materials Science Centre, †Central Research Facility, Optical Fibre Unit, Indian Institute of Technology,. Kharagpur 721 302, India. MS received 1 March 2004; revised 4 July 2004. Abstract. Er3+ and Er3+ : Yb3+ doped optical quality, crack and bubble free glasses for possible use in mak- ing laser material have been ...
Vidensledelse er også en social praksis
DEFF Research Database (Denmark)
Lauring, Jakob; Waldstrøm, Christian
2006-01-01
lys er det utroligt vigtigt at personalefunktionen i virksomheden er klar over de processer der udspiller sig, og aktivt tager fat om problemerne der ligger i disse barrierer. Vores egne undersøgelser viser, at på trods af opstillingen af teknologiske systemer til vidensdeling, er der stadig...... væsentlige ledelsesmæssige opgaver i forhold til sociale aspekter ved arbejdet i en organisation, som skal varetages hvis vidensdelingen skal fremmes succesfuldt. Det er væsentligt at forstå, at vidensledelse ikke blot handler om cirkulering af information, men også er forbundet mere generelt til ledelse som...
DEFF Research Database (Denmark)
Bentzen, Tina Øllgaard
2017-01-01
At fjerne styring er det, man ofte forbinder med afbureaukratisering, men det er ikke tilstrækkeligt, når man vil gå fra flotte ambitioner til en styring, som reelt opleves enklere. For at forenkle må man også forandre, forankre og fastholde styring, og det må ske i et samspil mellem de aktører, ...
DEFF Research Database (Denmark)
Pedersen, Kurt Møller
2005-01-01
Artiklen giver en oversigt over Ole Rømers videnskabelige liv som astronom, fysiker og matematiker samt hans betydning som kongelig embedsmand.......Artiklen giver en oversigt over Ole Rømers videnskabelige liv som astronom, fysiker og matematiker samt hans betydning som kongelig embedsmand....
ER Consolidated Quarterly Report October 2014
Energy Technology Data Exchange (ETDEWEB)
Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
2014-10-01
This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective actions and related Long- Term Stewardship (LTS) activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) ER for the April, May, and June 2014 quarterly reporting period. Section 2.0 provides the status of ER Operations activities including closure activities for the Mixed Waste Landfill (MWL), project management and site closure, and hydrogeologic characterizations. Section 3.0 provides the status of LTS activities that relate to the Chemical Waste Landfill (CWL) and the associated Corrective Action Management Unit (CAMU). Section 4.0 provides the references noted in Section I of this report.
DEFF Research Database (Denmark)
Bjerre-Harpøth, Vibeke; Damgaard, Birthe Marie
2013-01-01
Et forsøg har vist, at køer på lavt energiniveau i goldperioden var fysiologisk sundere og havde mindre risiko for at udvikle stofskiftesygdomme end køer på et højt energiniveau. Forsøget viste også, at køer på et normalt energiniveau i senlaktationen gav mere mælk i den efterfølgende laktation e...
DEFF Research Database (Denmark)
Olden-Jørgensen, Sebastian
2009-01-01
Ansatte på KU mobber hverken mere eller mindre end på andre danske arbejdspladser. Mediernes dækning af APV-undersøgelsens resultater mht. mobning er sensationalistisk og delvis vildledende.......Ansatte på KU mobber hverken mere eller mindre end på andre danske arbejdspladser. Mediernes dækning af APV-undersøgelsens resultater mht. mobning er sensationalistisk og delvis vildledende....
Spectral-converting behaviors of Er{sup 3+} and Er{sup 3+}–Yb{sup 3+} doped YOCl phosphors
Energy Technology Data Exchange (ETDEWEB)
Park, Sangmoon, E-mail: spark@silla.ac.kr [Center for Green Fusion Technology and Department of Engineering in Energy and Applied Chemistry, Silla University, Busan 617-736 (Korea, Republic of); Cho, So-Hye [Center for Materials Architecturing, Institute of Multidisciplinary Convergence of Materials, Korea Institute of Science and Technology, Seoul 130-650 (Korea, Republic of)
2014-01-25
Highlights: • Luminescent materials of YOCl:Er,Yb were prepared using NH{sub 4}Cl flux. • Interesting spectral-converting behaviors were observed in the phosphors. • 980 or 1550 nm diode laser was irradiated for up-converting study. • A multi-photon process in the phosphors was calculated. -- Abstract: Luminescent materials composed of Y{sub 1−m−n}Er{sub m}Yb{sub n}OCl (m = 0.001–0.1, n = 0.005–0.1) were prepared via a solid-state reaction using NH{sub 4}Cl flux. Photoluminescence spectra, the dependence of the luminescent intensity as a function of Er{sup 3+} content, and their CIE coordinates of the Er{sup 3+}-doped layered YOCl compounds were also investigated under near-ultraviolet (NUV) and visible lights. The spectral up-converting properties of Er{sup 3+} and Er{sup 3+}–Yb{sup 3+} in YOCl phosphors were elucidated under 980 and 1550 nm diode laser irradiations. This up-conversion emission spectra and the pump power dependence versus emission intensity observed in the Y{sub 0.9}Er{sub 0.1}OCl up-conversion phosphors gave rise to one- and two-photon processes. The up-conversion mechanism of Er{sup 3+} and Yb{sup 3+} ions in YOCl was described by a schematic energy-level diagram. Through the use of these up-conversion luminescent materials, the desired emitting lights throughout the orange and red regions of the spectra were achieved.
International Nuclear Information System (INIS)
Katoh, Hironori; Fujita, Keiko; Takuhara, Yuki; Ogawa, Atsushi; Suzuki, Shunji
2011-01-01
Highlights: → VIGG is an ER stress-induced protein in plant. → We examine the characteristics of VIGG-overexpressing Arabidopsis plants. → VIGG-overexpressing plants reveal growth retardation and robustness to ER stress. → VIGG disturbs cation homeostasis in plant. -- Abstract: VIGG is a putative endoplasmic reticulum (ER) resident protein induced by virus infection and ER stress, and is correlated with fruit quality in grapevine. The present study was undertaken to determine the biological function of VIGG in grapevine. Experiments using fluorescent protein-VIGG fusion protein demonstrated that VIGG is localized in ER and the ER targeting sequence is in the N-terminus. The overexpression of VIGG in Arabidopsis plant led to growth retardation. The rosette leaves of VIGG-overexpressing plants were smaller than those of the control plants and rolled at 42 days after seeding. VIGG-overexpressing plants revealed robustness to ER stress as well as the low expression of ER stress marker proteins, such as the luminal binding proteins. These characteristics of VIGG-overexpressing plants were supported by a microarray experiment that demonstrated the disruption of genes related to ER stress response and flowering, as well as cation mobility, in the plants. Finally, cation homeostasis in the plants was disturbed by the overexpression of VIGG. Taken together, these results suggest that VIGG may disturb cation homeostasis in plant, which is correlated with the robustness to ER stress and growth retardation.
Energy Technology Data Exchange (ETDEWEB)
Katoh, Hironori; Fujita, Keiko; Takuhara, Yuki [Laboratory of Fruit Genetic Engineering, The Institute of Enology and Viticulture, University of Yamanashi, Kofu, Yamanashi 400-0005 (Japan); Ogawa, Atsushi [Department of Biological Production, Akita Prefectural University, Shimosinjyou-nakano 241-438, Akita 010-0195 (Japan); Suzuki, Shunji, E-mail: suzukis@yamanashi.ac.jp [Laboratory of Fruit Genetic Engineering, The Institute of Enology and Viticulture, University of Yamanashi, Kofu, Yamanashi 400-0005 (Japan)
2011-02-18
Highlights: {yields} VIGG is an ER stress-induced protein in plant. {yields} We examine the characteristics of VIGG-overexpressing Arabidopsis plants. {yields} VIGG-overexpressing plants reveal growth retardation and robustness to ER stress. {yields} VIGG disturbs cation homeostasis in plant. -- Abstract: VIGG is a putative endoplasmic reticulum (ER) resident protein induced by virus infection and ER stress, and is correlated with fruit quality in grapevine. The present study was undertaken to determine the biological function of VIGG in grapevine. Experiments using fluorescent protein-VIGG fusion protein demonstrated that VIGG is localized in ER and the ER targeting sequence is in the N-terminus. The overexpression of VIGG in Arabidopsis plant led to growth retardation. The rosette leaves of VIGG-overexpressing plants were smaller than those of the control plants and rolled at 42 days after seeding. VIGG-overexpressing plants revealed robustness to ER stress as well as the low expression of ER stress marker proteins, such as the luminal binding proteins. These characteristics of VIGG-overexpressing plants were supported by a microarray experiment that demonstrated the disruption of genes related to ER stress response and flowering, as well as cation mobility, in the plants. Finally, cation homeostasis in the plants was disturbed by the overexpression of VIGG. Taken together, these results suggest that VIGG may disturb cation homeostasis in plant, which is correlated with the robustness to ER stress and growth retardation.
Energy Technology Data Exchange (ETDEWEB)
Akiyama, Y.; Heyde, K.; Arima, A.; Yoshinaga, N.
1986-05-29
Extending the interacting boson model by incorporating besides s and d, also the g-boson, we can describe the population of positive parity states of /sup 168/Er in the /sup 166/Er(t,P)/sup 168/Er reaction rather well. In particular, the excitation of I,Ksub(i)sup(..pi..) = 4,3/sub 1//sup +/; 2,2/sub 2//sup +/; 0,0/sub 3//sup +/ and 0,0/sub 4//sup +/ states is much improved over the sd-IBM appraoch.
Pæren er faldet langt fra stammen
DEFF Research Database (Denmark)
Haarder, Jon Helt
2013-01-01
Roman: Hassan Preislers vellykkede debutroman udleverer ikke bare multikulti-industrien. Den er også en rablende diagnosticering af det moderne menneskes livsvilkår HASSAN PREISLER BRUN MANDS BYRDE 224 sider, 249,95 Lindhardt og Ringhof Er udkommet 4......Roman: Hassan Preislers vellykkede debutroman udleverer ikke bare multikulti-industrien. Den er også en rablende diagnosticering af det moderne menneskes livsvilkår HASSAN PREISLER BRUN MANDS BYRDE 224 sider, 249,95 Lindhardt og Ringhof Er udkommet 4...
Er Web 2.0 klar til mainstream?
DEFF Research Database (Denmark)
Ivang, Reimer
2009-01-01
BLOG: Spørgsmålene der relateres til Web 2.0 er mange. Men en af de mest signifikante er om netop din virksomhed skal anvende Web 2.0 teknologier? Hvad kan I få ud af det?......BLOG: Spørgsmålene der relateres til Web 2.0 er mange. Men en af de mest signifikante er om netop din virksomhed skal anvende Web 2.0 teknologier? Hvad kan I få ud af det?...
MIT HJEM ER HVOR MIT HJERTE ER
DEFF Research Database (Denmark)
Høst, Jeppe Engset
2014-01-01
Ideen om at arbejde med det man kalder de stedbundne ressourcer på en ny måde, er relevant på Bornholm hvor events som blandt andet festivalen ’Wonderfestiwall’, strandfesten ’Vang Pier Beach Party’, karnevallet ’Svaneke Beach Party, kokkekonkurrencen ’Sol over Gudhjem’ og filmfestivalen ’Bornsho...
Markgraf, Daniel F; Klemm, Robin W; Junker, Mirco; Hannibal-Bach, Hans K; Ejsing, Christer S; Rapoport, Tom A
2014-01-16
Eukaryotic cells store neutral lipids such as triacylglycerol (TAG) in lipid droplets (LDs). Here, we have addressed how LDs are functionally linked to the endoplasmic reticulum (ER). We show that, in S. cerevisiae, LD growth is sustained by LD-localized enzymes. When LDs grow in early stationary phase, the diacylglycerol acyl-transferase Dga1p moves from the ER to LDs and is responsible for all TAG synthesis from diacylglycerol (DAG). During LD breakdown in early exponential phase, an ER membrane protein (Ice2p) facilitates TAG utilization for membrane-lipid synthesis. Ice2p has a cytosolic domain with affinity for LDs and is required for the efficient utilization of LD-derived DAG in the ER. Ice2p breaks a futile cycle on LDs between TAG degradation and synthesis, promoting the rapid relocalization of Dga1p to the ER. Our results show that Ice2p functionally links LDs with the ER and explain how cells switch neutral lipid metabolism from storage to consumption. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
Directory of Open Access Journals (Sweden)
Daniel F. Markgraf
2014-01-01
Full Text Available Eukaryotic cells store neutral lipids such as triacylglycerol (TAG in lipid droplets (LDs. Here, we have addressed how LDs are functionally linked to the endoplasmic reticulum (ER. We show that, in S. cerevisiae, LD growth is sustained by LD-localized enzymes. When LDs grow in early stationary phase, the diacylglycerol acyl-transferase Dga1p moves from the ER to LDs and is responsible for all TAG synthesis from diacylglycerol (DAG. During LD breakdown in early exponential phase, an ER membrane protein (Ice2p facilitates TAG utilization for membrane-lipid synthesis. Ice2p has a cytosolic domain with affinity for LDs and is required for the efficient utilization of LD-derived DAG in the ER. Ice2p breaks a futile cycle on LDs between TAG degradation and synthesis, promoting the rapid relocalization of Dga1p to the ER. Our results show that Ice2p functionally links LDs with the ER and explain how cells switch neutral lipid metabolism from storage to consumption.
ER Stress and Lipid Metabolism in Adipocytes
Directory of Open Access Journals (Sweden)
Beth S. Zha
2012-01-01
Full Text Available The role of endoplasmic reticulum (ER stress is a rapidly emerging field of interest in the pathogenesis of metabolic diseases. Recent studies have shown that chronic activation of ER stress is closely linked to dysregulation of lipid metabolism in several metabolically important cells including hepatocytes, macrophages, β-cells, and adipocytes. Adipocytes are one of the major cell types involved in the pathogenesis of the metabolic syndrome. Recent advances in dissecting the cellular and molecular mechanisms involved in the regulation of adipogenesis and lipid metabolism indicate that activation of ER stress plays a central role in regulating adipocyte function. In this paper, we discuss the current understanding of the potential role of ER stress in lipid metabolism in adipocytes. In addition, we touch upon the interaction of ER stress and autophagy as well as inflammation. Inhibition of ER stress has the potential of decreasing the pathology in adipose tissue that is seen with energy overbalance.
DEFF Research Database (Denmark)
Schubart, Rikke
2013-01-01
Indlæg om tv-serien Once Upon a Time (2011-), der hører til genren fairytale fantasy, der blander eventyr og fantasy. Her bliver alle eventyr brugt i en fortælling om alle beboere i en lille by, der ikke ved, at de i virkeligheden er eventyr-karakterer.......Indlæg om tv-serien Once Upon a Time (2011-), der hører til genren fairytale fantasy, der blander eventyr og fantasy. Her bliver alle eventyr brugt i en fortælling om alle beboere i en lille by, der ikke ved, at de i virkeligheden er eventyr-karakterer....
International Nuclear Information System (INIS)
Akane, T.; Jinno, S.; Yang, Y.; Kuno, T.; Hirata, T.; Isogai, Y.; Watanabe, N.; Fujiwara, Y.; Nakamura, A.; Takeda, Y.
2003-01-01
ErP has been grown on InP(0 0 1) substrates by organometallic vapor phase epitaxy (OMVPE) using a new liquid organic Er source: tris(ethylcyclopentadienyl)erbium (Er(EtCp) 3 ). Morphological change of an ErP layer on InP(0 0 1) is investigated together with that of an overgrown capping InP layer. Optimum growth condition of InP causes islanding on over-monolayer-ErP. A relatively low overgrowth temperature of InP is a key factor for attaining complete capping coverage on ErP
Hvorfor er sygeplejersker usynlige i offentlige medier?
DEFF Research Database (Denmark)
Joensen, Annemi Lund; Hall, Elisabeth
2015-01-01
Når der er sygeplejerelevante emner til debat i de offentlige medier på Færøerne, bærer debatten præg af sygeplejerskers manglende deltagelse. Sygeplejerskerne er usynlige. Et eksempel på dette er en debat om besparelser inden for ældreomsorgen. Til trods for at besparelsen fik omfattende konsekv...
Ny viden begynder med forhindringer
DEFF Research Database (Denmark)
Johansen, Martin Blok
2017-01-01
Pædagogik og pædagogisk arbejde diskuteres typisk inden for rammerne af det at hjælpe, støtte, simplificere og kompleksitetsreducere. Hvis man ønsker at vide noget om forhindringer, modstand og vanskeligheder som pædagogiske muligheder, så er udbuddet derimod forsvindende småt. Og når sådanne...... begreber endelig tages op, så benævnes de typisk blot, men bliver sjældent defineret. Hvad menes der med modstand, vanskeligheder eller kompleksitet? Med afsæt i en kort gennemgang af eksisterende forskning på området forsøger denne artikel at give et bud på en mulig definition af begrebet forhindring...
DEFF Research Database (Denmark)
Philipps, Morten; Andersen, Thomas Dyreborg
2014-01-01
Flipped classroom – en trend vi må forholde os til Online læringsressourcer har de sidste par år fået mange til at indse at teknologien har noget radikalt andet at byde på, og dette har skabt en populær didaktik kaldet flipped classroom som vi både ser vinde indpas i folkeskolen og på...... Professionshøjskolen Metropol hvor vi er ansat. Kommentaren her retter sig mod en tidligere bragt artikel i MONA, “Det virtuelle læringsrums topologi” af Claus Jessen. Vi argumenterer for at den didaktiske model flipped classrooms brug af video, frem for tavleundervisning, kan frigøre undervisningstid til at arbejde...
Brandulykker er et socialt problem
DEFF Research Database (Denmark)
Leth, Peter Mygind
1999-01-01
Det er de gamle, de syge, de handicappede og alkoholikerne, der brænder inde. Typisk har de tabt en cigaret eller tændstik på tøjet. En del af disse brandulykker opstår på plejehjem og andre institutioner, hvor det ofte er plejepersonalet, der opdager og slukker branden....
DEFF Research Database (Denmark)
Jensen, J. P.; Jeppesen, E.; Søndergaard, M.
Forord: Denne rapport er udarbej-det af Danmarks Mil-jøunder-søgelser som et led i den lands-dæk-ken-de rapportering af Vand-miljøpla-nens Over-vågningspro-gram. Over-vågningsprogram-met blev iværksat efteråret 1988. Hensigten med Vand-miljøplanens over-vågningsprogram er at undersøge effekten af......-miljøet med nærings-salte. Danmarks Miljøundersø-gelser har som sektor-forskningsinstitu-tion i Miljø- og Energiministeriet til opgave at forbedre og styrke det fagli-ge grundlag for de mil-jøpolitiske prioriteringer og beslut-ninger. En væsentlig del af denne opgave er overvågning af miljø og natur. Det er...
Arctigenin alleviates ER stress via activating AMPK
Gu, Yuan; Sun, Xiao-xiao; Ye, Ji-ming; He, Li; Yan, Shou-sheng; Zhang, Hao-hao; Hu, Li-hong; Yuan, Jun-ying; Yu, Qiang
2012-01-01
Aim: To investigate the protective effects of arctigenin (ATG), a phenylpropanoid dibenzylbutyrolactone lignan from Arctium lappa L (Compositae), against ER stress in vitro and the underlying mechanisms. Methods: A cell-based screening assay for ER stress regulators was established. Cell viability was measured using MTT assay. PCR and Western blotting were used to analyze gene and protein expression. Silencing of the CaMKKβ, LKB1, and AMPKα1 genes was achieved by RNA interference (RNAi). An ATP bioluminescent assay kit was employed to measure the intracellular ATP levels. Results: ATG (2.5, 5 and 10 μmol/L) inhibited cell death and unfolded protein response (UPR) in a concentration-dependent manner in cells treated with the ER stress inducer brefeldin A (100 nmol/L). ATG (1, 5 and 10 μmol/L) significantly attenuated protein synthesis in cells through inhibiting mTOR-p70S6K signaling and eEF2 activity, which were partially reversed by silencing AMPKα1 with RNAi. ATG (1-50 μmol/L) reduced intracellular ATP level and activated AMPK through inhibiting complex I-mediated respiration. Pretreatment of cells with the AMPK inhibitor compound C (25 μmol/L) rescued the inhibitory effects of ATG on ER stress. Furthermore, ATG (2.5 and 5 μmol/L) efficiently activated AMPK and reduced the ER stress and cell death induced by palmitate (2 mmol/L) in INS-1 β cells. Conclusion: ATG is an effective ER stress alleviator, which protects cells against ER stress through activating AMPK, thus attenuating protein translation and reducing ER load. PMID:22705729
Hvad er ledelse af brugerinddragelse?
DEFF Research Database (Denmark)
Holm-Petersen, Christina; Navne, Laura Emdal
2015-01-01
Brugerinddragelse i det danske sundhedsvæsen står højt på den politiske dagsorden, men det er stadig en udfordring at implementere visionen i klinisk praksis. Ledelse af brugerinddragelse bliver aktuelt udpeget som en central nøgle til at føre visionen ud i livet. Samtidig er der kun relativt lidt......, at brugerinddragelse skal implementeres i en verden, hvor der allerede er en række andre mål tilstede. En central ledelsesudfordring er derfor, at nogle af målene med brugerinddragelse forudsætter nye måder at organisere ikke bare arbejdet og kompetencer på, men også relationer til patienter og pårørende. En væsentlig...... that organize relations Patient involvement in the health services in Denmark is high on the political agenda, though continues to be a challenge to implement. It is increasingly said that leadership is crucial to the implementation process. However, research into the role of leaders in patient involvement...
Directory of Open Access Journals (Sweden)
Atsunobu Masuno
2016-02-01
Full Text Available Glasses with the composition xBaO–(99.9 − xSiO2–0.1ErO3/2 (0 ≤x ≤ 34.9 were fabricated by a levitation technique. The glasses in the immiscibility region were opaque due to chemical inhomogeneity, while the other glasses were colorless and transparent. The scanning electron microscope observations and electron probe microanalysis scan profiles revealed that more Er3+ ions were preferentially distributed in the regions where more Ba2+ ions existed in the chemically inhomogeneous glasses. The synchronicity of the spatial distributions of the two ions initially increased with increasing x and then decreased when the Ba2+ concentration exceeded a certain value. The peak shape and lifetime of the fluorescence at 1.55 μm depended on x as well as the spatial distribution of both ions. These results indicate that although ErOn polyhedra are preferentially coordinated with Ba2+ ions and their local structure is affected by the coordination of Ba2+, there is a maximum in the amount of Ba2+ ions that can coordinate ErOn polyhedra since the available space for Ba2+ ions is limited. These findings provide us with efficient ways to design the chemical composition of glasses with superior Er3+ fluorescence properties for optical communication network systems.
Forenklede Fælles Mål (i historie)
DEFF Research Database (Denmark)
Poulsen, Jens Aage
2015-01-01
forenklede Fælles Mål (FFM), som trådte i kraft august 2015. Undervisningsministeriets begrundede en ny læreplan med Danmarks Evalueringsinstituts undersøgelse fra 2012, som fastslog, at lærerne stort set ikke brugte Fælles Mål 2009 som styredokument, når de tilrettelagde undervisningen. Ministeriet ønskede...... den også skulle gøres mere brugervenlig, indgik ordet ’forenklede’ i betegnelsen. Samlet set er det nok en underdrivelse at tale om en ’revision’. En iøjnefaldende forskel på FFM og Fælles Mål 2009 er, at Fælles Mål 2009 – og også tidligere læreplaner – fokuserede på undervisningsmål, mens FFM er...... ompetenceorienteret og orienteret mod læringsmål, dvs. på hvad eleverne kan og ved. I den sammenhæng lancerede Undervisningsministeriet en vejledende læringsmålstyret didaktik. En virkeliggørelse af intentionerne i FFM forudsætter, at læreren planlægger, gennemfører og evaluerer undervisningen på en noget anden måde...
DEFF Research Database (Denmark)
Wistoft, Karen
Baggrund: Skolebørns opfattelse af sundhed har i høj grad noget med deres selvbilleder, trivsel og sociale inklusion at gøre. Det viser en lang række nyere undersøgelser, der alle peger på, at det er nødvendigt at skærpe opmærksomheden på børn og unges mentale sundhed. Internationalt er der...... udviklet og afprøvet en række pædagogiske programmer, der kan bruges til at igangsætte aktiviteter, der fremmer børn og unges mentale sundhed i skolen. Især i USA, Australien og Storbritannien har der været fokus på evidensbaseret praksis og praksisbaseret evidens i denne sammenhæng. I Danmark har man ikke...... på sammen måde tilgængelig systematiseret viden herom. Sundhedsstyrelsen har gennem de senere år prioriteret indsatser og fremskrivning af evidensgrundlag til fremme af mental sundhed højt. Betydningen af børns mentale sundhed og overvejelser om, hvilken slags evidens der er behov for på dette område...
Den rige personlighed er livsduelig
DEFF Research Database (Denmark)
Holm, Claus
2015-01-01
For omtrent 160 år siden formulerede Karl Marx forestillingen om en rig individualitet som det kommunistiske samfunds individideal. I dag får forestillingen relevans. Lyder det lidt besynderligt, er det ikke mærkeligt. For de fleste af os går næppe rundt og tror, at vi er lige på trapperne til...
Hvilke Dødehavstekster er "sekteriske"?
DEFF Research Database (Denmark)
Holst, Søren
2003-01-01
Skønt Dødehavsrullerne antageligt tilhørte en gruppering, der boede i Qumran, tyder alt på, at mange af teksterne er forfattet andre steder. Artiklen undersøger den særlige sprogbrug, som antageligt er typisk for Qumran-samfundet, og som præger forbavsende få af tekserne. En meget stor del af...
DEFF Research Database (Denmark)
Søltoft, Pia
2016-01-01
I modsætning til ironi er humor for Kierkegaard fællesskabsgivende – ironikeren hævder sig selv, men humoristen har sympati med den, man ler med. Humor er hos Kierkegaard udtryk for, at humoristen forliger sig med tilværelsen og dens luner, og dermed grænser humoren hos Kierkegaard op til det...
Employer branding er også intern kommunikation
DEFF Research Database (Denmark)
Hansen, Heidi
2016-01-01
I videnssamfundet og serviceøkonomien er medarbejderne virksomhedens vigtigste ressource, men milleniumgenerationen er ikke trofaste overfor deres arbejdsplads – de har typisk 15-20 jobs i løbet af deres livstid. Et stærkt employer brand bidrager til at fastholde medarbejdere – og dermed...... kompetencer – i virksomheden, og medarbejderne er dermed en central målgruppe for employer branding....
Hvorfor er danske fødevarer dyre?
DEFF Research Database (Denmark)
Hansen, Henning Otte
2015-01-01
De danske fødevarepriser er generelt høje set i forhold til resten af EU og også i forhold til lande uden for EU. Overordnet set er der en række forklaringer på internationale prisforskelle, og der er også flere mulige årsager til de høje danske fødevarepriser. Forskelle i moms, kvalitet...
Ytringsfriheden er ikke nødvendig
DEFF Research Database (Denmark)
Lauritzen, Pia
2008-01-01
nemlig godt konstatere, at ytringsfriheden ikke er nødvendig uden dermed at give afkald på frihed og demokrati.Vi kan oven i købet mene, at ytringsfriheden ophører med at være frihed, når vi betragter den som nødvendig. Og det er lige nøjagtig det, jeg efterlyser: at vi bruger filosoffer som Immanuel...... Kant og Luigi Pareyson til at forstå, at friheden er betydelig mere kompleks, end vi gør den til i øjeblikket....
TCSP ER-2 DOPPLER RADAR (EDOP) V1
National Aeronautics and Space Administration — The TCSP ER-2 DOPPLER RADAR (EDOP) dataset was collected by the ER-2 Doppler radar (EDOP), which is an X-band (9.6 GHz) Doppler radar mounted in the nose of the ER-2...
National Aeronautics and Space Administration — The CAMEX-4 ER-2 Doppler Radar dataset was collected by the ER-2 Doppler radar (EDOP), which is an X-band (9.6 GHz) Doppler radar mounted in the nose of ER-2. The...
DEFF Research Database (Denmark)
Olsen, Poul Bitsch
2008-01-01
Dansk håndbold er en kæmpemæssig succeshistorie. Ser man snævert på den udvikling, elitedelen af sporten har gennemlevet de seneste 15 år, viser stort set alle tænkelige parametre fremgang. De internationale resultater for lands og klubhold er med få udfald blevet stadigt bedre, omsætningen i klu...
International Nuclear Information System (INIS)
Polyakova, I. N.; Baulin, V. E.; Ivanova, I. S.; Pyatova, E. N.; Sergienko, V. S.; Tsivadze, A. Yu.
2015-01-01
The coordination compounds of Er 3+ with 1-(methoxydiphenylphosphoryl)-2-diphenylphosphorylbenzene [ErL 2 1 (NO 3 ) 2 ] 2 [Er(NO 3 ) 2 (H 2 O) 5 ] 0.333 (NO 3 ) 2.333 · 2.833H 2 O (I) and its ethyl substituted derivative [ErL 2 2 (NO 3 ) 2 ][Er(NO 3 ) 5 ] 0.5 · 0.5H 2 O (II) are synthesized and their crystal structures are studied. I and II contain [ErL 2 (NO 3 ) 2 ] + complex cations of identical composition and close structure. The eight-vertex polyhedron of the Er atom in the shape of a distorted octahedron with two split trans vertices is formed by the O atoms of the phosphoryl groups of L ligands and nitrate anions. L ligands close nine-membered metallocycles. The structures contain spacious channels which are populated differently, namely, by disordered [Er(NO 3 ) 2 (H 2 O) 5 ] + complex cations, NO 3 − anions, and crystallization water molecules in I and disordered [Er(NO 3 ) 5 ] 2− complex anions and crystallization water molecules in II. The IR spectra of I and II are studied
Dietary toxins, endoplasmic reticulum (ER) stress and diabetes.
Hettiarachchi, Kalindi D; Zimmet, Paul Z; Myers, Mark A
2008-05-01
The incidence of Type 1 diabetes has been increasing at a rate too rapid to be due to changes in genetic risk. Instead changes in environmental factors are the likely culprit. The endoplasmic reticulum (ER) plays an important role in the production of newly synthesized proteins and interference with these processes leads to ER stress. The insulin-producing beta cells are particularly prone to ER stress as a result of their heavy engagement in insulin production. Increasing evidence suggests ER stress is central to initiation and progression of Type 1 diabetes. An early environmental exposure, such as toxins and viral infections, can impart a significant physiological load on beta cells to initiate abnormal processing of proinsulin, ER stress and insulin secretory defects. Release of altered proinsulin from the beta cells early in life may trigger autoimmunity in those with genetic susceptibility leading to cytokine-induced nitric oxide production and so exacerbating ER stress in beta cells, ultimately leading to apoptosis of beta cells and diabetes. Here we suggest that ER stress is an inherent cause of beta cell dysfunction and environmental factors, in particular dietary toxins derived from Streptomyces in infected root vegetables, can impart additional stress that aggravates beta cell death and progression to diabetes. Furthermore, we propose that the increasing incidence of Type 1 diabetes may be accounted for by increased dietary exposure to ER-stress-inducing Streptomyces toxins.
Ikon. iPod er kongen over mp3. Hvad er hemmeligheden?
DEFF Research Database (Denmark)
Dickson, Thomas
2005-01-01
iPod er blevet ikonet for det 21. århundrede. Men iPod var hverken den første mp3-afspiller eller den første veldesignede af slagsen. Før iPod så dagens lys var Bang & Olufsen på banen med sin næsten lige så lækre BeoSound2.......iPod er blevet ikonet for det 21. århundrede. Men iPod var hverken den første mp3-afspiller eller den første veldesignede af slagsen. Før iPod så dagens lys var Bang & Olufsen på banen med sin næsten lige så lækre BeoSound2....
DEFF Research Database (Denmark)
2016-01-01
Valg af materiale/medie/form: YouTube Valg af arbejdsform: Videoerne kan bruges som caseundervisning Begrundelse for valg af materiale/medie/form/arbejdsform: Caseundervisning er velegnet til at lære om praksis......Valg af materiale/medie/form: YouTube Valg af arbejdsform: Videoerne kan bruges som caseundervisning Begrundelse for valg af materiale/medie/form/arbejdsform: Caseundervisning er velegnet til at lære om praksis...
International Nuclear Information System (INIS)
Yang, Ping; Fu, Shilong; Cao, Zhifei; Liao, Huaidong; Huo, Zihe; Pan, Yanyan; Zhang, Gaochuan; Gao, Aidi; Zhou, Quansheng
2015-01-01
Cancer cells have both tumor-adaptive and -suppressive endoplasmic reticulum (ER) stress machineries that determine cell fate. In malignant tumors including lymphoma, constant activation of tumor-adaptive ER stress and concurrent reduction of tumor-suppressive ER stress favors cancer cell proliferation and tumor growth. Current ER stress-based anti-tumor drugs typically activate both tumor-adaptive and -suppressive ER stresses, resulting in low anti-cancer efficacy; hence, selective induction of tumor-suppressive ER stress and inhibition of tumor-adaptive ER stress are new strategies for novel anti-cancer drug discovery. Thus far, specific tumor-suppressive ER stress therapeutics have remained absent in clinical settings. In this study, we explored unique tumor-suppressive ER stress agents from the traditional Chinese medicinal herb Oroxylum indicum, and found that a small molecule oroxin B selectively induced tumor-suppressive ER stress in malignant lymphoma cells, but not in normal cells, effectively inhibited lymphoma growth in vivo, and significantly prolonged overall survival of lymphoma-xenografted mice without obvious toxicity. Mechanistic studies have revealed that the expression of key tumor-adaptive ER-stress gene GRP78 was notably suppressed by oroxin B via down-regulation of up-stream key signaling protein ATF6, while tumor-suppressive ER stress master gene DDIT3 was strikingly activated through activating the MKK3-p38 signaling pathway, correcting the imbalance between tumor-suppressive DDIT3 and tumor-adaptive GRP78 in lymphoma. Together, selective induction of unique tumor-suppressive ER stress and concurrent inhibition of tumor-adaptive ER stress in malignant lymphoma are new and feasible approaches for novel anti-lymphoma drug discovery and anti-lymphoma therapy. - Highlights: • Oroxin B selectively induces tumor-suppressive ER stress in B-lymphoma cells. • Oroxin B significantly prolonged overall survival of lymphoma-xenografted mice.
Energy Technology Data Exchange (ETDEWEB)
Yang, Ping; Fu, Shilong; Cao, Zhifei; Liao, Huaidong; Huo, Zihe; Pan, Yanyan; Zhang, Gaochuan; Gao, Aidi; Zhou, Quansheng, E-mail: zhouqs@suda.edu.cn
2015-10-15
Cancer cells have both tumor-adaptive and -suppressive endoplasmic reticulum (ER) stress machineries that determine cell fate. In malignant tumors including lymphoma, constant activation of tumor-adaptive ER stress and concurrent reduction of tumor-suppressive ER stress favors cancer cell proliferation and tumor growth. Current ER stress-based anti-tumor drugs typically activate both tumor-adaptive and -suppressive ER stresses, resulting in low anti-cancer efficacy; hence, selective induction of tumor-suppressive ER stress and inhibition of tumor-adaptive ER stress are new strategies for novel anti-cancer drug discovery. Thus far, specific tumor-suppressive ER stress therapeutics have remained absent in clinical settings. In this study, we explored unique tumor-suppressive ER stress agents from the traditional Chinese medicinal herb Oroxylum indicum, and found that a small molecule oroxin B selectively induced tumor-suppressive ER stress in malignant lymphoma cells, but not in normal cells, effectively inhibited lymphoma growth in vivo, and significantly prolonged overall survival of lymphoma-xenografted mice without obvious toxicity. Mechanistic studies have revealed that the expression of key tumor-adaptive ER-stress gene GRP78 was notably suppressed by oroxin B via down-regulation of up-stream key signaling protein ATF6, while tumor-suppressive ER stress master gene DDIT3 was strikingly activated through activating the MKK3-p38 signaling pathway, correcting the imbalance between tumor-suppressive DDIT3 and tumor-adaptive GRP78 in lymphoma. Together, selective induction of unique tumor-suppressive ER stress and concurrent inhibition of tumor-adaptive ER stress in malignant lymphoma are new and feasible approaches for novel anti-lymphoma drug discovery and anti-lymphoma therapy. - Highlights: • Oroxin B selectively induces tumor-suppressive ER stress in B-lymphoma cells. • Oroxin B significantly prolonged overall survival of lymphoma-xenografted mice.
ER and PR expression and survival after endometrial cancer.
Smith, Deborah; Stewart, Colin J R; Clarke, Edward M; Lose, Felicity; Davies, Claire; Armes, Jane; Obermair, Andreas; Brennan, Donal; Webb, Penelope M; Nagle, Christina M; Spurdle, Amanda B
2018-02-01
To measure association between endometrial carcinoma ER and PR status and endometrial cancer (EC) survival, accounting for inter-observer variation. The intensity and proportion of tumor cell expression of ER and PR in ECs were assessed independently and semi-quantitatively by two pathologists using digital images of duplicate tumor tissue microarrays (TMAs). Cases with inconsistent initial assessment were reviewed and final scoring agreed. The association between overall and EC-specific survival and hormone receptor expression (intensity, proportion and combined) was assessed using Cox regression analysis. The C-index was used to evaluate model discrimination with addition of ER and PR status. Tumor ER and PR analysis was possible in 659 TMAs from 255 patients, and in 459 TMAs from 243 patients, respectively. Initial ER and PR scoring was consistent in 82% and 80% of cases, respectively. In multivariate analyses decreased ER and PR expression was associated with increased tumor-related mortality. Associations reached statistical significance for ER proportion score (P=0.05), ER intensity score (P=0.003), and PR combined score (P=0.04). Decreased expression of combined ER/PR expression was associated with poorer EC-specific survival than decreased expression of either hormone receptor alone (P=0.005). However, hormone receptor status did not significantly improve mortality prediction in individual cases. ER and PR expression combined, using cut-points that capture variation in scoring and across cores, is significantly associated with EC-specific survival in analyses adjusting for known prognostic factors. However, at the individual level, ER and PR expression does not improve mortality prediction. Copyright © 2017 Elsevier Inc. All rights reserved.
DEFF Research Database (Denmark)
Møberg, Rasmus Juul
normativ fordring. Kohlis (2007) formulering af normalbiografien er en tredeling af livsforløbet (uddannelse – arbejdsliv - pension). En tredeling der bliver kritiseret for at være køns- og familieblind, hvorfor linked lives-begrebet bliver introduceret. Begrebet har den teoretiske implikation...... analyser tager højde for afhængighed over tid i den afhængige variabel. Overordnet set er det tre aspekter af datas karakteristika, der fordrer specielle metoder. Det er censurering af data, tidsmæssig variation i de uafhængige variable samt potentiel korrelation mellem målingerne af den afhængige variabel...... for disse ændringer, hvorved risikoen for en given transition beregnes mere præcist. Afhandlingens empiriske grundlag er registerdata for alle personer i Danmark, der tilhører fødselskohorterne 1968, 1972 og 1976. Data dækker over personlige, familiære forhold og oplysninger på arbejdspladsniveau, hvor den...
ER2OWL: Generating OWL Ontology from ER Diagram
Fahad, Muhammad
Ontology is the fundamental part of Semantic Web. The goal of W3C is to bring the web into (its full potential) a semantic web with reusing previous systems and artifacts. Most legacy systems have been documented in structural analysis and structured design (SASD), especially in simple or Extended ER Diagram (ERD). Such systems need up-gradation to become the part of semantic web. In this paper, we present ERD to OWL-DL ontology transformation rules at concrete level. These rules facilitate an easy and understandable transformation from ERD to OWL. The set of rules for transformation is tested on a structured analysis and design example. The framework provides OWL ontology for semantic web fundamental. This framework helps software engineers in upgrading the structured analysis and design artifact ERD, to components of semantic web. Moreover our transformation tool, ER2OWL, reduces the cost and time for building OWL ontologies with the reuse of existing entity relationship models.
International Nuclear Information System (INIS)
Świerczek, Konrad; Klimkowicz, Alicja; Zheng, Kun; Dabrowski, Bogdan
2013-01-01
In this paper, we report on a synthesis procedure, structural and electrical properties of BaErMn 2 O 5 and BaErMn 2 O 6 , A-site double perovskites having layered arrangement of Ba and Er cations. These materials belong to a family of BaLnMn 2 O 5+δ oxides, which up to now were successfully synthesized for Ln=Y and La–Ho lanthanides. Up to our knowledge, this is the first report on the successful synthesis of BaErMn 2 O 5 and BaErMn 2 O 6 , yielding>95 wt% of the considered compounds. Structural characterization of the materials is given at room temperature, together with in situ XRD studies, performed during oxidation of BaErMn 2 O 5 in air, at elevated temperatures up to 500 °C. A complex structural behavior was observed, with oxidation process of BaErMn 2 O 5 occurring at around 300 °C. The oxidized BaErMn 2 O 6 shows a structural phase transition at about 225 °C. Results of structural studies are supported by thermogravimetric measurements of the oxidation process, performed in air, as well as reduction process, preformed in 5 vol% of H 2 in Ar. Additionally, isothermal oxidation/reduction cycles were measured at 500 °C, showing interesting properties of BaErMn 2 O 5+δ , from a point of view of oxygen storage technology. Electrical conductivity of BaErMn 2 O 5 is of the order of 10 −4 S cm −1 at room temperature and shows activated character on temperature with activation energy E a =0.30(1) eV. Positive sign of Seebeck coefficient for this material indicates holes as dominant charge carriers. Oxidized BaErMn 2 O 6 possesses much higher electrical conductivity, almost 0.2 S cm −1 at room temperature. Additional, about 10-fold increase of electrical conductivity, occurring in the vicinity of 225 °C for this material, can be associated with phase transition from charge/orbital-ordered insulator COI(CE) to paramagnetic metal PM phase. The highest conductivity for BaErMn 2 O 6 was measured near 500 °C and is almost equal to 40 S cm −1 , while
Multiple band structure in 156Er
International Nuclear Information System (INIS)
Sunyar, A.W.; Der Mateosian, E.; Kistner, O.C.; Johnson, A.; Lumpkin, A.H.; Thieberger, P.
1976-01-01
The 142 Nd( 18 O,4n) 156 Er reaction at 90-95 MeV was used to study 156 Er high-spin states to spin 24. In addition to the background ground-state band, two well developed off-spin side bands, one of each parity, were observed. (Auth.)
Er formen blevet vigtigst i politik?
DEFF Research Database (Denmark)
Etemadi, Maziar Haghpaidar
2005-01-01
RETORIK: Retorikken er kunsten at tage ordet - skriftligt eller mundtligt - og udtrykke sig smukt og velformuleret. Gorgias (ca. 490-ca. 390 f. Kr.) fra Leontinoi på Sicilien betragtes som ophavsmanden til den første endelige formulering af retorikkens virke og muligheder: "Talen er en mægtig...
DEFF Research Database (Denmark)
Klausen, Kurt Klaudi
2017-01-01
Artiklen gennemgår kort de tre F'er: at fremskrive, forudse og forestille som strategiske værktøjer til strategic forecast......Artiklen gennemgår kort de tre F'er: at fremskrive, forudse og forestille som strategiske værktøjer til strategic forecast...
Heggen, Vilde Stuvøy
2014-01-01
Det er kanskje ingen overraskelse at man i internettalderen har funnet på en valuta som kun eksisterer på nett. Per i dag eksisterer det flere slike nettvalutaer, med varierende grad av oppslutning. Spørsmålet som stilles i oppgaven er hva slags formuerettslig objekt digital valuta er. Jeg regner digital valuta som alle valutaer som hovedsakelig er å finne på nett og som ikke utstedes av eller på vegne av en statsmakt. Definisjonen omfatter både kryptovalutaer som Bitcoin, som nok er mest kje...
MicroRNAs meet calcium: joint venture in ER proteostasis.
Finger, Fabian; Hoppe, Thorsten
2014-11-04
The endoplasmic reticulum (ER) is a cellular compartment that has a key function in protein translation and folding. Maintaining its integrity is of fundamental importance for organism's physiology and viability. The dynamic regulation of intraluminal ER Ca(2+) concentration directly influences the activity of ER-resident chaperones and stress response pathways that balance protein load and folding capacity. We review the emerging evidence that microRNAs play important roles in adjusting these processes to frequently changing intracellular and environmental conditions to modify ER Ca(2+) handling and storage and maintain ER homeostasis. Copyright © 2014, American Association for the Advancement of Science.
DEFF Research Database (Denmark)
Schilhab, Theresa
2014-01-01
Hvor ’konkret’ skal en oplevelse være, for at intuitionen om, at det selvoplevede styrker læringen, holder? Er brug af tablets (e.g. iPads) et ligebyrdigt alternativ til den konkrete oplevelse?......Hvor ’konkret’ skal en oplevelse være, for at intuitionen om, at det selvoplevede styrker læringen, holder? Er brug af tablets (e.g. iPads) et ligebyrdigt alternativ til den konkrete oplevelse?...
Interlayer exchange coupling in Er|Tb superlattices mediated by short range incommensurate Er order
International Nuclear Information System (INIS)
Pfuhl, E; Brueckel, T; Voigt, J; Mattauch, S; Korolkov, D
2010-01-01
We study the magnetic correlations in Er|Tb superlattices by means of off-specular scattering of polarized neutrons. We show here the co-existence of inhomogeneous magnetic states: i) ferromagnetic order of moments within the Tb layers below 230 K (FM), correlation length of about 10 bilayer, ii) an incommensurate modulated magnetic order, restricted to single Er layers and iii) antiferromagnetic coupling of ferromagnetic layers below 70K (AFC). Polarised off-specular neutron scattering under grazing incidence reveals that i) magnetic fluctuations appear when the sample is cooled below 70 K, ii) these fluctuations lead to AFC, when the sample is cooled to 10 K, which iii) persists, when the sample is subsequently heated up to 45 K, while the order is not present during the cooling cycle. Also the short range incommensurate order changes accordingly, implying that the magnetic order in the Er layers mediates the interlayer coupling between ferromagnetic Tb layers.
Er frygten for Kina vores eneste håb?
DEFF Research Database (Denmark)
Mehlsen, Camilla
2011-01-01
Man siger, at håbet er lysegrønt, men i det 21. århundrede er håbet rødt som riget i midten. Mens optimismen vinder frem i Asien med Kina som bannerfører, er Vesten ramt af frygt, og det forplanter sig negativt til uddannelsessystemet. Er positive følelser hemmeligheden bag, at asiatiske lande st...... stormer frem i internationale undersøgelser som PISA?...
Nationale test – Ønskede egenskaber og indfriede krav?
Directory of Open Access Journals (Sweden)
Peter Allerup
2016-03-01
Full Text Available De danske nationale test fulde navn er egentlig ”De Nationale It-baserede Adaptive Obligatoriske Test”. Det fulde navn fremhæver, til forskel fra det forkortede, flere vigtige sider af disse test i sammenligning med mange andre typer af test. Altså nogle signaler om, hvad der gør netop disse test specielle. Testene er resultatet af nogle krav om udvikling af nye evalueringsinstrumenter, som fandt sted for ca. 15 år siden, og i dag indgår testene rutinemæssigt i skolens hverdag. Derfor er det også et passende tidspunkt at spørge, om nogle af de krav og intentioner, der oprindeligt lå bag ved udviklingen, faktisk er blevet indfriet og kan demonstreres opfyldt gennem egenskaber, som man kan undersøge via indsamlede data i dag. Denne artikel har til formål at beskrive et par af de oprindelige krav: Sammenlignelighed af testresultater, adaptiv-itet i forhold til elevers færdighedsniveau og evne til at formidle brugbare evalueringsresultater – set i lys af deres aktualitet i den pædagogiske verden dengang og nu. Vi kan med et kik over skulderen i dag spørge, om det blev, som vi ønskede og krævede det – eller om der mangler noget?
Mukherjee, Subhendu; Saha, Achintya; Roy, Kunal
2005-02-15
Considering importance of developing selective estrogen receptor modulators (SERMs), the present paper explores selectivity requirements of tetrahydroisoquinoline derivatives for binding with ER(alpha) versus ER(beta) receptors using E-state index and physicochemical parameters. The best model [n=21, Q(2)=0.512, R(a)(2)=0.613, R=0.819, F=11.6 (df 3,17)] for ER(alpha) binding data obtained from radioligand binding assay showed importance of C(1), C(15) and lipophilicity (logP) while the best model [n=21, Q(2)=0.768, R(a)(2)=0.796, R=0.904, F=40.1 (df 2,18)] for ER(beta) binding data showed importance of C(1) and molar refractivity (MR). While modeling ER(alpha)/ER(beta) selectivity [n=21, Q(2)=0.695, R(a)(2)=0.739, R=0.882, F=19.8 (df 3,17)], C(1), C(15) and molar refractivity were found to be significant contributors. The data obtained from cellular transcription assay were also modeled. In case of ER(alpha), the best equation involving E-state values of C(1) and C(14) and logP explained 62.1% of the variance while the best equation for ER(beta) involving E-state values of C(1) and C(15) and MR explained 64.6% of the variance of the response variable. In case of ER(alpha)/ER(beta) selectivity, the best equation involving E-state values of O(8), C(14) and N(27) showed 48.3% explained variance, which increased to 63.5% on deletion of single outlier. From the analysis it appears that the nitrogen atom of the aminoethoxyphenyl substituent and 6-hydroxy substituent of the tetrahydroisoquinoline nucleus play important roles for ER(alpha)/ER(beta) selectivity in addition to R(1) and R(2) substituents.
Operational durability of a giant ER valve for Braille display
Luning, Xu; Han, Li; Yufei, Li; Shen, Rong; Kunquan, Lu
2017-05-01
The compact configuration of giant ER (electrorheological) valves provides the possibility of realizing a full-page Braille display. The operational durability of ER valves is a key issue in fulfilling a Braille display. A giant ER valve was used to investigate the variations in pressure drops and critical pressure drops of the valves over a long period under some typical operational parameters. The results indicate that neither the pressure drops nor critical pressure drops of giant ER valves show apparent deterioration over a long period. Without ER fluid exchange, a blockage appears in the channel of the valve because the ER structures induced by an external electric field cannot be broken by the Brownian motion of hydraulic oil molecules when the external electric field is removed. Forcing ER fluid flow is an effective and necessary method to keep the channel of the valve unblocked. Thus the operational durability of the valve using giant ER fluids is able to meet the demands of Braille display.
Hvordan er det å leve med CRPS?
Hovind, Thomas
2014-01-01
Hensikten med denne studien er å se på hvordan pasienter med komplekst regionalt smertesyndrom (CRPS) opplever å leve med tilstanden og hvordan disse pasientene har opplevd å bli møtt i helsevesenet. CRPS er en langvarig tilstand med sterke smerter som kan medføre økt smerterespons, redusert funksjon og nedsatt livskvalitet hos pasientene. Studien er en kvalitativ undersøkelse basert på dybdeintervju av fire pasienter med CRPS. Pasientene ble rekruttert fra en smerteavdeling i Nord-Norge og u...
Branding er ikke til at komme udenom
DEFF Research Database (Denmark)
Hermansen, Judy
2008-01-01
Søren Askegaard definerer branding som "et iscenesat og afkodet symbolunivers". Det vil sige, at vi på den ene side har virksomhedens strategiske profilering, hvor den forsøger at skabe sig en særlig differentieret og positioneret profil, som adskiller den fra andre virksomheder. "Og det er denne...... strategiske kommunikation, der gør at branding er et ledelsesbegreb og ikke kun et markedsføringsbegreb. Det er ikke staffage, men værdier, som skal gennemsyre alle organisationens aktiviteter." Udgivelsesdato: maj...
Praktikuddannelse, kendte og miskendte sider
DEFF Research Database (Denmark)
Larsen, Kristian
, evalueringssamtaler etc. Den konventionelle forestilling om læring (fra lærer til studerende, fra tanke til handling etc.) kan til dels bekræftes, men den fremstår samtidig som en stærkt accentueret og overestimeret dimension af, hvad praktikuddannelse er. Den miskender gennem sin ideologiske konstruktion...... styrende end at anvende teori i praktik eller at lære noget af aktiviteterne. Habitus guider en søgende og defensiv praktik ud fra et forsigtighedsprincip. Strategier kan være at stille de rette spørgsmål på rette sted og måde, først spørge når man nogenlunde ‘ved', vise sin uvidenhed frem for at gøre den...
Er der en underviser til stede?
DEFF Research Database (Denmark)
Christiansen, René Boyer; Nortvig, Anne-Mette; Rosenlund, Lea Tilde
2015-01-01
I de senere år er MOOC (Massive Open Online Courses) blevet en faktor på uddannelsesområdet. MOOC-forskning er et forholdsvist nyt felt, men har inden for de seneste 2-3 år udviklet sig med hastige skridt (Liyanagunawardena et al. 2013, Bayne & Ross 2014). En stor del af denne forskning har haft...
"Det man siger er man selv..."
DEFF Research Database (Denmark)
Næsby, Torben; Nørgaard, Britta; Uddholm, Mats
forhold, der er hermeneutisk, strukturelt og relationelt bestemt. Praksisviden kan ikke være objektiv i gængs forstand, men det behøver ikke at diskvalificere denne viden. Forståelse er altid knyttet til den sag og bundet til den situation man står overfor og i som professionel og som menneske....
Barz, W P; Walter, P
1999-04-01
Many eukaryotic cell surface proteins are anchored in the lipid bilayer through glycosylphosphatidylinositol (GPI). GPI anchors are covalently attached in the endoplasmic reticulum (ER). The modified proteins are then transported through the secretory pathway to the cell surface. We have identified two genes in Saccharomyces cerevisiae, LAG1 and a novel gene termed DGT1 (for "delayed GPI-anchored protein transport"), encoding structurally related proteins with multiple membrane-spanning domains. Both proteins are localized to the ER, as demonstrated by immunofluorescence microscopy. Deletion of either gene caused no detectable phenotype, whereas lag1Delta dgt1Delta cells displayed growth defects and a significant delay in ER-to-Golgi transport of GPI-anchored proteins, suggesting that LAG1 and DGT1 encode functionally redundant or overlapping proteins. The rate of GPI anchor attachment was not affected, nor was the transport rate of several non-GPI-anchored proteins. Consistent with a role of Lag1p and Dgt1p in GPI-anchored protein transport, lag1Delta dgt1Delta cells deposit abnormal, multilayered cell walls. Both proteins have significant sequence similarity to TRAM, a mammalian membrane protein thought to be involved in protein translocation across the ER membrane. In vivo translocation studies, however, did not detect any defects in protein translocation in lag1Delta dgt1Delta cells, suggesting that neither yeast gene plays a role in this process. Instead, we propose that Lag1p and Dgt1p facilitate efficient ER-to-Golgi transport of GPI-anchored proteins.
Die HECT-Ligase Hul5, eine neue Komponente der ER-assoziierten Proteindegradation
Kohlmann, Sonja
2007-01-01
Die meisten sekretorischen Proteine der eukaryontischen Zellen erreichen durch das endoplasmatische Retikulum (ER) den sekretorischen Signalweg. Sie gelangen vom Zytoplasma durch einen Kanal in der ER-Membran in das ER, wo sie ihre native Konformation erhalten. Das ER enthält ein strenges Qualitätskontrollsystem, welches fehlgefaltete Proteine erkennt, im ER zurückhält und letztendlich der ER-assoziierten Degradation (ERAD) zuführt. Die ER-Qualitätskontrolle und die ER-assoziierte Degradation...
Vejen til helvede er brolagt med frelste intentioner
DEFF Research Database (Denmark)
Vestenskov, David
2013-01-01
Det åbenlyse spørgsmål omkring, hvorfor vi er i Afghanistan (eller hvorfor vi bliver?) er bestemt et relevant spørgsmål, men at klæbe et prædikat på om krigens manglende moralske troværdighed kræver mere end blot sure opstød. Er vi netop ikke blevet i Afghanistan grundet moralske principper?...
Matematik Dersinde İsteğe Bağlı Çevrimiçi Kısa Sınav Uygulanması Hakkında Öğrenci Görüşleri
Directory of Open Access Journals (Sweden)
Harun ÇİĞDEM
2014-12-01
Full Text Available Bu çalışmanın amacı öğrencilerin harmanlanmış öğretim kapsamında kullandıkları çevrimiçi quiz sistemi hakkındaki görüşlerinin ortaya konmasıdır. Harmanlanmış öğretim, yüz yüze öğretim ile web tabanlı öğrenme yönetim sisteminin birlikte kullanılmasıyla oluşturulmuştur. Betimsel yöntem desenindeki çalışma bir meslek yüksekokulunda Matematik-I dersini alan 204 öğrenci üzerinde gerçekleştirilmiştir. Dersler sınıf ortamında yürütülmüş ve intranet üzerinden öğrencilere powerpoint (ppt sunuları, ders notları ve quizler sunulmuştur. Çevrimiçi quizler ile ünite bazlı toplam 126 maddelik çoktan seçmeli test maddesi havuzundan öğrencilerin yararlanmaları sağlanmıştır. Dönem sonunda öğrencilerin çevrimiçi quizler hakkındaki görüşlerini belirlemek amacıyla Çevrimiçi Quiz Değerlendirme Formu kullanılmıştır. Hazırlanan form, 103 öğrenci tarafından cevaplanmıştır. Verilerin analizinde frekans, ortalama ve t testi kullanılmıştır. Öğrencilerin genel olarak çevrimiçi quiz konusunda kararsız kaldıkları belirlenmiştir. Bilgisayar sahibi olan öğrencilerin bilgisayar sahibi olmayanlara göre, evinde internet bağlantısı olan öğrencilerin evinde internet bağlantısı olmayan öğrencilere göre ve daha önce web tabanlı sınav deneyimi olan öğrencilerin, web tabanlı sınav konusunda herhangi bir deneyimi olmayan öğrencilere göre çevrimiçi quizler konusunda daha olumlu oldukları bulunmuştur. Çevrimiçi quiz uygulamasının soru bankasının oluşturulmasının özellikle Matematik dersi için oldukça zaman alıcı olduğu belirlenmiştir. Uygulamanın en önemli avantajları öğrenci quizlerini okumak için gereken zamanın azalması ve kaynakların etkin kullanılmasıdır.
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization.
LENUS (Irish Health Repository)
Gupta, Sanjeev
2010-01-01
During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and the mitochondrial permeability transition pore on ER stress-induced MOMP and subsequent cell death. Induction of ER stress leads to upregulation of several genes such as Grp78, Edem1, Erp72, Atf4, Wars, Herp, p58ipk, and ERdj4 and leads to caspase activation, release of mitochondrial intermembrane proteins and dissipation of mitochondrial transmembrane potential (DeltaPsim). Mouse embryonic fibroblasts (MEFs) from caspase-9, -2 and, -3 knock-out mice were resistant to ER stress-induced apoptosis which correlated with decreased processing of pro-caspase-3 and -9. Furthermore, pretreatment of cells with caspase inhibitors (Boc-D.fmk and DEVD.fmk) attenuated ER stress-induced loss of DeltaPsim. However, only deficiency of caspase-9 and -2 could prevent ER stress-mediated loss of DeltaPsim. Bcl-2 overexpression or pretreatment of cells with the cell permeable BH4 domain (BH4-Tat) or the mitochondrial permeability transition pore inhibitors, bongkrekic acid or cyclosporine A, attenuated the ER stress-induced loss of DeltaPsim. These data suggest a role for caspase-9 and -2, Bcl-2 family members and the mitochondrial permeability transition pore in loss of mitochondrial membrane potential during ER stress-induced apoptosis.
Sker der noget med læringdudbyttet, når undervisningssproget skiftes?
Directory of Open Access Journals (Sweden)
Camilla Falk Rønne Nissen
2016-04-01
Full Text Available I takt med en øget internationalisering af de videregående uddannelser øges mængden af undervisning på engelsk på de danske universiteter. Men hvilke konsekvenser har det for kvaliteten af undervisningen? Falder læringsudbyttet, når der undervises på et sprog, der for de fleste universitetsstuderende og undervisere ikke er deres førstesprog? Denne artikel prøver gennem et litteraturreview at finde svar i den eksisterende, forskningsbaserede litteratur. Første del af reviewet identificerer interesseområder i forskningen, mens anden del gennemgår resultater fra enkelte studier med fokus på læring og deltagelse, særligt i en nordisk kontekst. The internationalization of higher education has driven Danish universities to increase the amount of teaching in English. But what are the consequences for the quality of the education? Is the quality of the learning outcome compromised when teaching and learning activities take place in a second language? Based on a literature review of existing, research-based literature, this article tries to offer some answers to that question. The first part of the review identifies different research interests, while the second part of the review discusses results from selected studies that have focused on student learning and activity, especially within a Nordic setting.
Per Nørgårds “nordiske" periode
DEFF Research Database (Denmark)
Nielsen, Rie B.; Bonde, Anders
1997-01-01
s. 491-653 + bilag Per Nørgård (f. 1932) er en af de nulevende danske komponister, hvis musik har givet anledning til flest skriverier. Det være sig i bøger, aviser, tidsskrifter m.m. Samtidigt foreligger fra komponisten selv et væld af artikler og manuskripter, omhandlende musikteori, analyser......, kulturkritik m.m. I en lang række af disse skrifter fra især 1980'erne og 1990'erne dukker ordet "interferens" til stadighed op i såvel Per Nørgårds egne som andres udtalelser og kommentarer, knyttet til hans kompositoriske virke. Interferensfænomenet har med tiden vist sig at have en helt central placering i...... forbindelse med hans musik, dog uden at der på noget tidspunkt er opstillet fyldestgørende definitioner af begrebet. Samtidig har Per Nørgård flere gange fremhævet, hvorledes interferensen synes at stå som en overordnet fællesnævner for hele hans produktion trods store stilistiske forskelle. Som følge deraf...
The new ternary pnictides Er12Ni30P21 and Er13Ni25As19: Crystal structures and magnetic properties
International Nuclear Information System (INIS)
Oryshchyn, Stepan; Babizhetskyy, Volodymyr; Zhak, Olga; Zelinska, Mariya; Pivan, Jean-Yves; Duppel, Viola; Simon, Arndt; Kienle, Lorenz
2010-01-01
The new ternary pnictides Er 12 Ni 30 P 21 and Er 13 Ni 25 As 19 have been synthesized from the elements. They crystallize with hexagonal structures determined from single-crystal X-ray data for Er 12 Ni 30 P 21 (space group P6 3 /m, a=1.63900(3) nm, c=0.37573(1) nm, Z=1, R F =0.062 for 1574 F-values and 74 variable parameters), and for Er 13 Ni 25 As 19 (Tm 13 Ni 25 As 19 -type structure, space group P6-bar , a=1.6208(1) nm, c=0.38847(2) nm, Z=1, R F =0.026 for 1549 F-values and 116 variable parameters). These compounds belong to a large family of hexagonal structures with a metal-metalloid ratio of 2:1. HRTEM investigations were conducted to probe for local ordering of the disordered structure at the nanoscale. The magnetic properties of the phosphide Er 12 Ni 30 P 21 have been studied in the temperature of range 2 eff =9.59 μ B corresponds to the theoretical value of Er 3+ . - Graphical abstract: The new ternary pnictides Er 12 Ni 30 P 21 and Er 13 Ni 25 As 19 have been synthesized from the elements. They crystallize with hexagonal structures determined from single-crystal X-ray data. The compounds belong to a large family of structures with a metal-metalloid ratio of 2:1. HRTEM investigations were conducted to probe for local ordering of the disordered structure at the nanoscale. Display Omitted
DEFF Research Database (Denmark)
Wind, P.
resultaterne af orkidéovervågningen (Wind 2001). Hertil kommer præsentationen af projektet og dets resultater efter forløbet af de første tre år (Løjtnant 1991a) og en bearbejdning af projektets resultater for årene 1987-1995 (Wind 1997). I nærværende rapport undersøges skov-hullæbe for en eventuel sammenhæng...... mellem skudanlæggelsen udtrykt ved antallet af blomstrende og vegetative skud i et givet år og nedbørsmængder i august og september året før. Det er en udbredt antagelse at der er en sammenhæng mellem skudanlæggelse og mængden af nedbør det foregående år. Undersøgelser af skov-hullæbe populationer i...... truet og sårbar samt de to arter der er omfattet af Habitatdirektivets bilag 2. I 2000 kan det i forhold til 1999 konstateres at der i 15 bestande er optalt et øget antal skud. I 11 bestande er der noteret en nedgang i antallet af skud sammenlignet med optællingerne i 1999. Af disse er der 2 be...
DEFF Research Database (Denmark)
Bach-Nielsen, Carsten
2015-01-01
Om et kors, der er rejst uden for den danske kirke i Bruxelles; formodentlig en afledning af det såkaldte Brabanterkors.......Om et kors, der er rejst uden for den danske kirke i Bruxelles; formodentlig en afledning af det såkaldte Brabanterkors....
Design Program in Graphic User Interface Environment for Automobile ER Devices
Lim, S. C.; Park, J. S.; Sohn, J. W.; Choi, S. B.
This work presents a design and analysis program for vehicle devices utilizing an electrorheological (ER) fluid. The program is operated in graphic user interface (GUI) environment and the initial window is consisted of four subprogram modules which are related to ER shock absorber, ER seat damper, ER engine mount, and ER anti-lock brake system (ABS), respectively. In order to execute each module, both material properties and design parameters are to be chosen by the user. Then, the output display window shows the field-dependent performance characteristics to be considered as design criteria. In addition, control performances of the vehicle system equipped with ER devices are displayed in time and frequency domain. In order to demonstrate the effectiveness of the proposed program, ER shock absorber and ER ABS are designed and manufactured and their performance characteristics are evaluated.
En af anarkister tilberedt sardindåse
DEFF Research Database (Denmark)
Thing, Morten
2005-01-01
Henrik Pontoppidan bruger 'det jødiske' som tema i sit forfatterskab, især i Lykke-Per, til at gestalte 'det moderne' som noget fremmed.......Henrik Pontoppidan bruger 'det jødiske' som tema i sit forfatterskab, især i Lykke-Per, til at gestalte 'det moderne' som noget fremmed....
Directory of Open Access Journals (Sweden)
Semirhan Gökçe
2016-04-01
Full Text Available Learning and teaching process of math and the form of how we use math has been reshaped with the radical innovations in science and technology in recent years. One of the important factors in the education field which the realization of change and development are undoubtedly connected is teachers. When considered in the literature, it is seen that teachers has lacking in effective use of information-communication technologies and integrated in the teaching process, also it seems that they feel inadequate in using information-communication technologies. From this determination, it is aimed to investigate teachers’ views on the feasibility and effectiveness of worksheets which are developed in this study to allow teachers using GeoGebra in the teaching process without expert assistance in lesson and before the lesson. A case study of the research method is used. The participants of the study are five mathematics teachers that are working in a High School. In collecting the data, semi-structured interviews were used. Results were handled with the themes which are the effects of worksheets, the impact of worksheets on students and the process of education and training required for the implementation feasibility. Worksheets are expected to provide contribution to teachers who want to use computer effectively in their teaching process since the worksheets; are student centered, has an instructive structure of a software intended for computer assisted education and can be implemented with the basic computer knowledge, especially without expert assistance. [Son yıllarda bilim ve teknoloji alanındaki köklü yenilikler, matematiği kullanma biçimimiz ile matematik öğrenme ve öğretme süreçlerimizi yeniden biçimlendirmiştir. Eğitim alanında değişim ve gelişimin gerçekleşmesinin bağlı olduğu etkenlerden biri kuşkusuz öğretmenlerdir. Alanyazın incelendiğinde, öğretmenlerin bilgi-iletişim teknolojilerini etkili biçimde kullanma
Structural and electronic properties of Er-monopnictides under high pressure
International Nuclear Information System (INIS)
Pandit, Premlata; Srivastava, Vipul; Rajagopalan, M.; Sanyal, Sankar P.
2010-01-01
We present the results of theoretical calculations on the structural, magnetic and electronic properties of Er-monopnictides using self-consistent first principles tight-binding linear-muffin-tin-orbital (TB-LMTO) method within the atomic-sphere approximation (ASA). Both spin-polarized and non-spin-polarized calculations are performed to check the magnetic stability of these compounds. We find that ErN, ErP and ErAs are metallic in ferromagnetic (FM) phase in both the spin channels and stable in NaCl-type (B 1 ) structure at ambient pressure. We predict NaCl-type (B 1 ) to CsCl-type (B 2 ) structural phase transition in ErN, ErP and ErAs at pressures of 146.1, 60.2 and 53.2 GPa, respectively and remain metallic ferromagnetic at high pressure. We calculate equilibrium lattice constants (a), bulk modulus (B), magnetic moments (μ B ) and electronic properties of these compounds in B 1 and B 2 phases and compare with available experimental and theoretical results.
International Nuclear Information System (INIS)
Wang, Ying; Xie, Xiumin; Qi, Jianqi; Wang, Shanshan; Wei, Nian; Lu, Zhongwen; Chen, Xingtao; Lu, Tiecheng
2016-01-01
We report on the sintering promoting and fluorescent activator roles of Er 3+ in AlON:Er 3+ transparent ceramics prepared by pressureless sintering with Er 2 O 3 and AlON powder. There shows that the transparency of samples varied with the content of Er 2 O 3 additive. The AlON:Er 3+ ceramics showed upconversion luminescence peaking at 546 nm, 662 nm and 840 nm under the 980 nm excitation due to transition of 4 S 3/2 / 2 H 11/2 → 4 I 15/2 , 4 F 9/2 → 4 I 15/2 and 4 S 3/2 / 2 H 11/2 → 4 I 13/2 of Er 3+ ions, respectively. The infrared spectra exhibited strong emission at 1534 nm corresponds to 4 I 13/2 → 4 I 15/2 transition. The mechanism of the IR and visible emission bands in AlON:Er 3+ ceramics are discussed, which suggest it should be attractive for lighting and display devices applications.
DEFF Research Database (Denmark)
Tække, Jesper
2014-01-01
Den store vision for world wide web var, at alle kunne få ubegrænset adgang til alverdens information. www var mangfoldigt og anarkistisk. I dag er der rigtig mange, der kun bruger nettet til at være på Facebook. Hvad bruger Facebook det til? Og hvad gør det ved vores udsyn?......Den store vision for world wide web var, at alle kunne få ubegrænset adgang til alverdens information. www var mangfoldigt og anarkistisk. I dag er der rigtig mange, der kun bruger nettet til at være på Facebook. Hvad bruger Facebook det til? Og hvad gør det ved vores udsyn?...
Trump er godt nyt for verdensfreden
DEFF Research Database (Denmark)
Jakobsen, Peter Viggo
2017-01-01
Trumps uberegnelighed øger ikke risikoen for krig. Den mindsker den ved at få de allierede til at gøre mere og modstanderne til at forhandle. Det er godt for verdensfreden......Trumps uberegnelighed øger ikke risikoen for krig. Den mindsker den ved at få de allierede til at gøre mere og modstanderne til at forhandle. Det er godt for verdensfreden...
Optical energy gaps and photoluminescence peaks of BaGa2S4:Er3+ and BaGa2Se4:Er3+ single crystals
International Nuclear Information System (INIS)
Choe, Sung-Hyu; Jin, Moon-Seog; Kim, Wha-Tek
2005-01-01
BaGa 2 S 4 :Er 3+ and BaGa 2 Se 4 :Er 3+ single crystals were grown by using the chemical transport reaction method. The optical energy gaps of the BaGa 2 S 4 :Er 3+ and the BaGa 2 Se 4 :Er 3+ single crystals were found to be 4.045 eV and 3.073 eV, respectively, at 11 K. The temperature dependence of the optical energy gap was well fitted by the Varshni equation. Sharp emission peaks were observed in the photoluminescence spectra of the single crystals and assigned to radiation recombination between split Stark levels of the Er 3+ ion.
Er{sup 3+} Doping conditions of planar porous silicon waveguides
Energy Technology Data Exchange (ETDEWEB)
Najar, A. [Laboratoire d' Optronique UMR 6082-FOTON, Universite de Rennes 1, 6 rue de Kerampont, B. P. 80518, 22305 Lannion Cedex (France); Laboratoire de Spectroscopie Raman, Faculte des Sciences de Tunis, 2092 El Manar, Tunis (Tunisia); Lorrain, N., E-mail: nathalie.lorrain@univ-rennes1.fr [Laboratoire d' Optronique UMR 6082-FOTON, Universite de Rennes 1, 6 rue de Kerampont, B. P. 80518, 22305 Lannion Cedex (France); Ajlani, H. [Laboratoire de Spectroscopie Raman, Faculte des Sciences de Tunis, 2092 El Manar, Tunis (Tunisia); Charrier, J. [Laboratoire d' Optronique UMR 6082-FOTON, Universite de Rennes 1, 6 rue de Kerampont, B. P. 80518, 22305 Lannion Cedex (France); Oueslati, M. [Laboratoire de Spectroscopie Raman, Faculte des Sciences de Tunis, 2092 El Manar, Tunis (Tunisia); Haji, L. [Laboratoire d' Optronique UMR 6082-FOTON, Universite de Rennes 1, 6 rue de Kerampont, B. P. 80518, 22305 Lannion Cedex (France)
2009-11-15
EDX and infrared photoluminescence (IR PL) analyses performed on erbium-doped porous silicon waveguides (PSWG) were studied using different doping conditions. Both parameters of the cathodisation electrochemical method used for Er incorporation and parameters of thermal treatments required for Er optical activation were taken into consideration. Firstly, by varying the current density and the time of cathodisation, we have shown that a current density of 0.1 mA/cm{sup 2} for 10 min allows homogeneous Er doping to be achieved throughout the depth of the guiding layer. Then, the PL intensity at 1.53 {mu}m was studied as a function of the oxidation time at 900 deg. C and Er diffusion temperature for 60 min. Increasing the oxidation time up to 1 h allows PL to be enhanced due to active Si-O-Er complex formation whereas an oxidation time of 2 h induces a decrease in PL because of Er segregation. Moreover, an increase in the diffusion temperature induces an optimal distribution of optically active Si-Er-O complexes inside the crystallites. When the temperature is too high, a PSWG densification and Er segregation occurs inducing a decrease in PL due to energy transfer phenomena.
Forbruget af træer og buske i Danmark
DEFF Research Database (Denmark)
Jensen, Jan Svejgaard; Laursen, Allan Bach; Kjær, Erik Dahl
Træer og buske er vigtige elementer i byen og landskabet, og i Danmark bruges der mellem 60 og 80 millioner vedplanter hvert år. Forbruget har været konstant stigende og der er sket store forskydninger i forbrugsmønstret i retning af større fokus på mangfoldighed og autencitet. Undersøgelsen...... klarlægger forbrugsmønstret for træer og buske og undersøger, hvad brugerne lægger vægt på i deres valg af planter....
Preparation of Erbium-169 (169Er) Using Natural Erbium Target
International Nuclear Information System (INIS)
Azmairit Aziz; Nana Suherman
2009-01-01
The therapeutic radiopharmaceuticals which is labelled by β-particle emission are now increasingly used in nuclear medicine. Erbium-169 ('1 69 Er) is one of radioisotopes that can be used for radiation synovectomy (radio synovectomy) in the treatment of inflammatory joint diseases (arthritis) due to its β- particle emission (T 1/2 =9.4 days, E β maximum =0.34 MeV). The preliminary study on preparation of 169 Er by using natural erbium oxide (Er 2 O 3 ) target irradiated at TRIGA 2000 Bandung reactor has been carried out. The irradiated target was dissolved in hydrochloric acid solution and gentle warming. The optimum condition of 169 Er preparation was obtained by dissolution of 169 Er 2 O 3 by using 1N HCl solution. The radiochemical purity of 169 ErCl 3 was determined by paper chromatography, thin layer chromatography and paper electrophoresis techniques. The solution of 169 ErCl 3 formed was obtained with the pH of 1.5 – 2, clear, with the specific activity of 0.48 – 0.71 MBq/mg Er. The solution has the radiochemical purity of 98.32 ± 1.28% and the radionuclide purity of 99.98%. Study on the stability of 169 ErCl 3 solution showed that the solution was still stable for 4 days at room temperature with the radiochemical purity more than 95%. (author)
Gingival melanin depigmentation by Er:YAG laser: A literature review.
Pavlic, Verica; Brkic, Zlata; Marin, Sasa; Cicmil, Smiljka; Gojkov-Vukelic, Mirjana; Aoki, Akira
2018-04-01
Laser ablation is recently suggested as a most effective and reliable technique for depigmentation of melanin hyperpigmented gingiva. To date, different lasers have been used for gingival depigmentation (CO 2 , diode, Nd:YAG, Er:YAG and Er,Cr:YSGG lasers). The use of Er:YAG laser for depigmentation of melanin hyperpigmented gingiva has gained increasing importance in recent years. The purpose of this study was to report removal of gingival melanin pigmentation using an Er:YAG laser in a literature review. The main outcomes, such as improvement of signs (clinical parameters of bleeding, erythema, swelling and wound healing), symptoms (pain) and melanin recurrence/repigmentation were measured. The literature demonstrated that depigmentation of gingival melanin pigmentation can be performed safely and effectively by Er:YAG laser resulting in healing and an esthetically significant improvement of gingival discoloration. Thus, Er:YAG laser seems to be safe and useful in melanin depigmentation procedure. However, the main issue in giving the final conclusion of the optimal Er:YAG laser use in melanin depigmentation is that, to date, studies are offering completely discrepant Er:YAG laser procedure protocols (complex settings of laser parameters), and different criteria for the assessment of depigmentation and repigmentation (recurrence), thus hampering the comparison of the results. Therefore, further studies are necessary to give an optimal recommendation on the use of Er:YAG laser in gingival melanin hyperpigmentation.
Growth process and structure of Er/Si(100) thin film
International Nuclear Information System (INIS)
Fujii, S.; Michishita, Y.; Miyamae, N.; Suto, H.; Honda, S.; Okado, H.; Oura, K.; Katayama, M.
2006-01-01
The solid-phase reactive epitaxial growth processes and structures of Er/Si(100) thin films were investigated by coaxial impact-collision ion scattering spectroscopy (CAICISS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The as-deposited Er film grown at room temperature was transformed into crystalline rectangular-shaped islands after annealing at 900 deg. C. These islands have a hexagonal AlB 2 -type structure and the epitaxial relationship is determined to be ErSi 2 (011-bar0)[0001]//Si(100)[011-bar]. It has been revealed that the surface of the Er silicide island is terminated with an Er plane
Directory of Open Access Journals (Sweden)
Louise M. Saija
2012-09-01
Full Text Available Salah satu standar yang diberikan oleh National Council of Teachers of Mathematics (NCTM adalah disposisi matematik. Disposisi bukan sekedar merujuk pada sikap tetapi suatu kecenderungan untuk berpikir dan bersikap dalam cara yang positif. Penelitian ini bertujuan untuk menganalisa disposisi matematik dan hubungannya dengan hasil belajar matematika siswa-siswa sekolah menengah atas (SMA. Sampel pada penelitian ini adalah 149 siswa SMA di Bandung. Analisa statistik didasarkan pada korelasi peringkat Spearman dan uji-t. Ditemukan bahwa secara rata-rata, disposisi matematik dari siswa-siswa SMA dikategorikan rendah. Selanjutnya, terdapat korelasi positif dan signifikan antara disposisi matematik dan hasil belajar matematika siswa-siswa SMA, walaupun nilai koefisien korelasinya tidak tinggi. Suatu observasi juga dilakukan untuk menganalisa hubungan ini, dan didapati bahwa walaupun beberapa siswa memiliki disposisi matematik yang baik, kadang kala mereka tidak dapat menyelesaikan ujian dengan baik, karena padatnya kurikulum, dan juga aktifitas sosial mereka, yang membuat hasil belajar matematika mereka lebih rendah. Temuan lainnya adalah bahwa siswa-siswa SMA memerlukan guru-guru matematika dengan lebih banyak strategi mengajar agar mereka dapat memiliki disposisi matematik yang lebih baik. Kata Kunci: Disposisi Matematik, Hasil Belajar Matematika One of the evaluation standards given by the National Council of Teachers of Mathematics (NCTM was mathematical disposition. Disposition refers not simply to attitudes but to a tendency to think and to act in positive ways. This study aimed to analyze the mathematical disposition and its correlation with mathematics achievement of senior high school (SMA students. A total of 149 SMA students in Bandung were procured as samples. Statistical analysis was based on the Spearman rank correlation and on the t-test. The findings showed that at average, the mathematical disposition of the SMA
Krigens første offer er også truet i fredstid
DEFF Research Database (Denmark)
Serritzlev, Jeanette
2018-01-01
Sandheden er krigens første offer, lyder det. Men informationskrig finder også sted i fredstid, og også her er sandheden jaget vildt. ’Fake News’ er det nye modeord, selv om det ikke er nyt. Det behøver ikke at være værre, end vi selv gør det. Det farlige opstår først, når vi er ligeglade....
Biocompatible Er:(Na,K)NbO3 nanofibers
Markova, N. P.; Grishin, A. M.
2017-11-01
Dense homogeneous fabric composed from continuous bead-free erbium-doped sodium potassium niobate (Er:NKN) 100 μm long and 100-200 nm in diameter nanofibers was sintered by sol-gel calcination assisted electrospinning technique. Er doping with the concentration of 2 at.% provides readily detectable room-temperature broad-band photoluminescence (PL) centered at λPL = 0.55 and 0.98 μm being pumped, respectively, with 532 and 785 nm lasers. Electric field induced resistance switching and strong electric rectification effect were found in nanoporous sandwich Au/Er:NKN/Pt capacitive cell. Memristor-type current-voltage I-V characteristics originate from the electrochemical migration of oxygen vacancies at the n-type Er:NKN oxide/high work function Pt cathode junction interface.
Æstetik er tilbage som nøgle til at forstå samtiden
DEFF Research Database (Denmark)
Sharma, Devika
2013-01-01
Casper Christensen er gakket, Hello Kitty er nuttet og konceptkunsten er interessant. Her er tre nye kategorier at forstå senkapitalismen med. I anledning af Sianne Ngais bog "Our aesthetic categories: zany, cute, interesting" .......Casper Christensen er gakket, Hello Kitty er nuttet og konceptkunsten er interessant. Her er tre nye kategorier at forstå senkapitalismen med. I anledning af Sianne Ngais bog "Our aesthetic categories: zany, cute, interesting" ....
Når mindset er nøglen til succes
DEFF Research Database (Denmark)
Nielsen, Jeppe Agger; Karlsmose, Jens; Kortnum, Allan
2016-01-01
Hvordan skaber man en arbejdspladskultur, hvor medarbejderne trives med forandringer, er udholdende og indstillede på at lære nyt? Det er for mange virksomheder et af de helt store aktuelle spørgsmål, og i flere af dem er svaret ledelse med mindsetbaserede principper. Læs her om mindset-tanketank...
Rantong, Gaolathe; Evans, Rodger; Gunawardena, Arunika H L A N
2015-10-01
The lace plant, Aponogeton madagascariensis, is an aquatic monocot that forms perforations in its leaves as part of normal leaf development. Perforation formation occurs through developmentally regulated programmed cell death (PCD). The molecular basis of PCD regulation in the lace plant is unknown, however ethylene has been shown to play a significant role. In this study, we examined the role of ethylene receptors during perforation formation. We isolated three lace plant ethylene receptors AmERS1a, AmERS1b and AmERS1c. Using quantitative PCR, we examined their transcript levels at seven stages of leaf development. Through laser-capture microscopy, transcript levels were also determined in cells undergoing PCD and cells not undergoing PCD (NPCD cells). AmERS1a transcript levels were significantly lower in window stage leaves (in which perforation formation and PCD are occurring) as compared to all other leaf developmental stages. AmERS1a and AmERS1c (the most abundant among the three receptors) had the highest transcript levels in mature stage leaves, where PCD is not occurring. Their transcript levels decreased significantly during senescence-associated PCD. AmERS1c had significantly higher transcript levels in NPCD compared to PCD cells. Despite being significantly low in window stage leaves, AmERS1a transcripts were not differentially expressed between PCD and NPCD cells. The results suggested that ethylene receptors negatively regulate ethylene-controlled PCD in the lace plant. A combination of ethylene and receptor levels determines cell fate during perforation formation and leaf senescence. A new model for ethylene emission and receptor expression during lace plant perforation formation and senescence is proposed.
Herp enhances ER-associated protein degradation by recruiting ubiquilins
International Nuclear Information System (INIS)
Kim, Tae-Yeon; Kim, Eunmin; Yoon, Sungjoo Kim; Yoon, Jong-Bok
2008-01-01
ER-associated protein degradation (ERAD) is a protein quality control system of ER, which eliminates misfolded proteins by proteasome-dependent degradation and ensures export of only properly folded proteins from ER. Herp, an ER membrane protein upregulated by ER stress, is implicated in regulation of ERAD. In the present study, we show that Herp interacts with members of the ubiquilin family, which function as a shuttle factor to deliver ubiquitinated substrates to the proteasome for degradation. Knockdown of ubiquilin expression by small interfering RNA stabilized the ERAD substrate CD3δ, whereas it did not alter or increased degradation of non-ERAD substrates tested. CD3δ was stabilized by overexpressed Herp mutants which were capable of binding to ubiquilins but were impaired in ER membrane targeting by deletion of the transmembrane domain. Our data suggest that Herp binding to ubiquilin proteins plays an important role in the ERAD pathway and that ubiquilins are specifically involved in degradation of only a subset of ubiquitinated targets, including Herp-dependent ERAD substrates
DEFF Research Database (Denmark)
Markgraf, Daniel F; Klemm, Robin W; Junker, Mirco
2014-01-01
Eukaryotic cells store neutral lipids such as triacylglycerol (TAG) in lipid droplets (LDs). Here, we have addressed how LDs are functionally linked to the endoplasmic reticulum (ER). We show that, in S. cerevisiae, LD growth is sustained by LD-localized enzymes. When LDs grow in early stationary...... phase, the diacylglycerol acyl-transferase Dga1p moves from the ER to LDs and is responsible for all TAG synthesis from diacylglycerol (DAG). During LD breakdown in early exponential phase, an ER membrane protein (Ice2p) facilitates TAG utilization for membrane-lipid synthesis. Ice2p has a cytosolic...... and explain how cells switch neutral lipid metabolism from storage to consumption....
Energy Technology Data Exchange (ETDEWEB)
Burck, Andreas
2008-11-04
This thesis describes the development of large-area magnetic calorimeters which could for example be used for the investigation of the dissociative recombination or the measurement of the Lamb-shift for hydrogenlike heavy ions. The detectors consist of two meandershaped niobium thin film pickup coils and a paramagnetic sensor. The deposition of energy in the sensor results in a temperature change and therefore in a change of magnetisation of the sensor, which can be measured by a SQUID-magnetometer with high precision. As sensormaterials a dilute alloy of gold-erbium (Au:Er) as well as silver-erbium (Ag:Er) were used. Whereas the Ag:Er-sensor was glued on the pickup coil the Au:Er-sensor was for the first time microstructured by a novel microstructuring process established in this thesis. For the characterisation of the detectors and the sensormaterials a fluorescence source and a {sup 55}Fe source were used. The thermodynamic properties of the Au:Er-sensors thereby show promising results, as the magnetisation shows bulk properties down to 20 mK. The measurements of the signalize and the magnetisation with the detector which was equipped with a Ag:Er-sensor showed that the thermodynamic properties of the Ag:Eralloy could be fully described. Furthermore the shape of the pulses, the noise and the energy resolution of both detectors will be discussed. (orig.)
Snip snap snude - dobbelthagerne er ude
DEFF Research Database (Denmark)
Larsen, Malene Charlotte; Kofoed, Jette
2015-01-01
Det handler om at være grim. Det står i skarp kontrast til det pæne og polerede på Instagram. Det er flygtigt, useriøst og ligegyldigt. Og så forsvinder det heldigvis igen, så man behøver kun at forholde sig til det i de få sekunder, det foregår. Snapchat vokser i popularitet og er nu det...
International Nuclear Information System (INIS)
Zhang Jisen; Qin Weiping; Zhao Dan; Degejihu; Zhang Jishuang; Wang Yan; Cao Chunyan
2007-01-01
In comparison with the up-conversion spectra of Yb 3+ -Er 3+ codopded systems reported previously, the interesting intensity changes of up-conversion luminescence between the violet, the blue, the green and the red on the both Er 3+ ion concentration and excitation density with 978 nm laser diodes as an excitation source were observed in Yb 3+ -Er 3+ codopded LaF 3 powders. In order to clarify the change mechanisms, the up-conversion spectra of LaF 3 : 10 mol% Yb 3+ , 0.5 mol% Er 3+ and LaF 3 : 10 mol% Yb 3+ , 1 mol% Er 3+ were investigated and the results indicated that the cross-relaxation processes between Er 3+ ions and the thermal population of the 2 H 11/2 level play significant roles
DNA as a component of ER materials
International Nuclear Information System (INIS)
Minagawa, K; Aoki, Y; Berber, M R; Mori, T; Tanaka, M
2009-01-01
Deoxyribonucleic acid (DNA), which is known as a typical biopolymer, has been utilized for a few types of ER materials. Suspensions were prepared with the particles of DNA, DNA/lipid complexes, and LDH (layered double hydroxide)/DNA composites. The purified DNA showed larger ER effect than the others, but this particle tended to absorb water, which caused less stability. Preliminary experiments of preparing composite with LDH indicated that this inorganic material would be useful for hydrophobic modification of DNA particles, although further optimization of composite preparation is needed. In addition, the LDH/DNA suspensions showed interesting behaviours under some conditions, which indicated possibility for controlling ER property in a wide range.
DNA as a component of ER materials
Energy Technology Data Exchange (ETDEWEB)
Minagawa, K; Aoki, Y; Berber, M R [Institute of Technology and Science, University of Tokushima, Tokushima 770-8506 (Japan); Mori, T [Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 819-0395 (Japan); Tanaka, M [Faculty of Pharmaceutical Science, Tokushima Bunri University, Tokushima 770-8514 (Japan)], E-mail: minagawa@chem.tokushima-u.ac.jp
2009-02-01
Deoxyribonucleic acid (DNA), which is known as a typical biopolymer, has been utilized for a few types of ER materials. Suspensions were prepared with the particles of DNA, DNA/lipid complexes, and LDH (layered double hydroxide)/DNA composites. The purified DNA showed larger ER effect than the others, but this particle tended to absorb water, which caused less stability. Preliminary experiments of preparing composite with LDH indicated that this inorganic material would be useful for hydrophobic modification of DNA particles, although further optimization of composite preparation is needed. In addition, the LDH/DNA suspensions showed interesting behaviours under some conditions, which indicated possibility for controlling ER property in a wide range.
Evaluating the potential bioactivity of a novel compound ER1626.
Wang, Lijun; Zeng, Yanyan; Wang, Tianling; Liu, Hongyi; Xiao, Hong; Xiang, Hua
2014-01-01
ER1626, a novel compound, is a derivate of indeno-isoquinoline ketone. This study was designed to evaluate the biological activity and potential anti-tumor mechanism of ER1626. MTT assay, scratch assay and flow cytometry were used to determine cell proliferation, cell migration and cell cycle distribution as well as cell apoptosis on human breast cancer MCF-7 cells and endometrial cancer Ishikawa cells. We also explored the antiangiogenic effect of ER1626 on HUVEC cells and chicken embryos. The expression of estrogen receptor protein was investigated with western-blot analysis. ER1626 down-regulated the expression of estrogen receptor α protein and up-regulated β protein in MCF-7 and Ishikawa cells. The value of IC50 of ER1626 on MCF-7 and Ishikawa cells were respectively 8.52 and 3.08 µmol/L. Meanwhile, ER1626 decreased VEGF secretion of MCF-7 and Ishikawa cells, disturbed the formation of VEGF-stimulated tubular structure in HUVEC cells, and inhibited the angiogenesis on the chicken chorioallantoic membrane. Scratch assay revealed that ER1626 suppressed the migration of MCF-7, Ishikawa and HUVEC cells. In addition to induction tumor cell apoptosis, ER1626 arrested cell cycle in G1/G0 phase in MCF-7 cells and G2/M phase in Ishikawa cells. In conclusion, our results demonstrated that ER1626 has favorable bioactivities to be a potential candidate against breast cancer and angiogenesis.
Evaluating the potential bioactivity of a novel compound ER1626.
Directory of Open Access Journals (Sweden)
Lijun Wang
Full Text Available ER1626, a novel compound, is a derivate of indeno-isoquinoline ketone. This study was designed to evaluate the biological activity and potential anti-tumor mechanism of ER1626.MTT assay, scratch assay and flow cytometry were used to determine cell proliferation, cell migration and cell cycle distribution as well as cell apoptosis on human breast cancer MCF-7 cells and endometrial cancer Ishikawa cells. We also explored the antiangiogenic effect of ER1626 on HUVEC cells and chicken embryos. The expression of estrogen receptor protein was investigated with western-blot analysis.ER1626 down-regulated the expression of estrogen receptor α protein and up-regulated β protein in MCF-7 and Ishikawa cells. The value of IC50 of ER1626 on MCF-7 and Ishikawa cells were respectively 8.52 and 3.08 µmol/L. Meanwhile, ER1626 decreased VEGF secretion of MCF-7 and Ishikawa cells, disturbed the formation of VEGF-stimulated tubular structure in HUVEC cells, and inhibited the angiogenesis on the chicken chorioallantoic membrane. Scratch assay revealed that ER1626 suppressed the migration of MCF-7, Ishikawa and HUVEC cells. In addition to induction tumor cell apoptosis, ER1626 arrested cell cycle in G1/G0 phase in MCF-7 cells and G2/M phase in Ishikawa cells.In conclusion, our results demonstrated that ER1626 has favorable bioactivities to be a potential candidate against breast cancer and angiogenesis.
Structural and electronic properties of Er-monopnictides under high pressure
Energy Technology Data Exchange (ETDEWEB)
Pandit, Premlata, E-mail: lataprem29@gmail.co [Department of Physics, Barkatullah University, Bhopal, Madhya Pradesh 462026 (India); Srivastava, Vipul [Department of Physics, Oriental Institute of Science and Technology, Thakral Nagar, Bhopal (India); Rajagopalan, M. [Crystal Growth Centre, Anna University, Chennai 600 025 (India); Sanyal, Sankar P. [Department of Physics, Barkatullah University, Bhopal, Madhya Pradesh 462026 (India)
2010-05-01
We present the results of theoretical calculations on the structural, magnetic and electronic properties of Er-monopnictides using self-consistent first principles tight-binding linear-muffin-tin-orbital (TB-LMTO) method within the atomic-sphere approximation (ASA). Both spin-polarized and non-spin-polarized calculations are performed to check the magnetic stability of these compounds. We find that ErN, ErP and ErAs are metallic in ferromagnetic (FM) phase in both the spin channels and stable in NaCl-type (B{sub 1}) structure at ambient pressure. We predict NaCl-type (B{sub 1}) to CsCl-type (B{sub 2}) structural phase transition in ErN, ErP and ErAs at pressures of 146.1, 60.2 and 53.2 GPa, respectively and remain metallic ferromagnetic at high pressure. We calculate equilibrium lattice constants (a), bulk modulus (B), magnetic moments (mu{sub B}) and electronic properties of these compounds in B{sub 1} and B{sub 2} phases and compare with available experimental and theoretical results.
Isothermal section of the Er-Cu-Ga ternary system at 973 K
Energy Technology Data Exchange (ETDEWEB)
Belgacem, B. [Unite de Recherche de Chimie des Materiaux et de l' Environnement (UR11ES25), ISSBAT, Universite de Tunis ElManar, 9 Avenue Dr. Zoheir Safi, 1006 Tunis (Tunisia); Pasturel, M., E-mail: mathieu.pasturel@univ-rennes1.fr [Institut des Sciences Chimiques de Rennes, Chimie du Solide et Materiaux, UMR CNRS 6226, Universite de Rennes 1, Campus de Beaulieu, 35042 Rennes (France); Tougait, O. [Institut des Sciences Chimiques de Rennes, Chimie du Solide et Materiaux, UMR CNRS 6226, Universite de Rennes 1, Campus de Beaulieu, 35042 Rennes (France); Nouri, S. [Unite de Recherche de Chimie des Materiaux et de l' Environnement (UR11ES25), ISSBAT, Universite de Tunis ElManar, 9 Avenue Dr. Zoheir Safi, 1006 Tunis (Tunisia); Bekkachi, H. El; Peron, I. [Institut des Sciences Chimiques de Rennes, Chimie du Solide et Materiaux, UMR CNRS 6226, Universite de Rennes 1, Campus de Beaulieu, 35042 Rennes (France); Hassen, R. Ben [Unite de Recherche de Chimie des Materiaux et de l' Environnement (UR11ES25), ISSBAT, Universite de Tunis ElManar, 9 Avenue Dr. Zoheir Safi, 1006 Tunis (Tunisia); Noeel, H. [Institut des Sciences Chimiques de Rennes, Chimie du Solide et Materiaux, UMR CNRS 6226, Universite de Rennes 1, Campus de Beaulieu, 35042 Rennes (France)
2012-08-05
Highlights: Black-Right-Pointing-Pointer The isothermal section at 973 K of the Er-Cu-Ga ternary phase diagram has been established for the first time. Black-Right-Pointing-Pointer Eight extensions of binary compounds in the ternary domain have been identified, as well as six ternary intermediate solid solutions characterized by an important Cu/Ga mutual substitution. Black-Right-Pointing-Pointer Magnetic properties of Er{sub 3}(Cu,Ga){sub 11} are reported for the first time and confirms the paramagnetic Curie-Weiss behavior of all the six intermediate intermetallics. - Abstract: Phase relations in the Er-Cu-Ga ternary system have been established at 973 K by means of powder X-ray diffraction complemented by energy dispersive spectroscopy coupled to scanning electron microscopy. The isothermal section of the phase diagram comprises eight extensions of binaries into the ternary system, ErCu{sub 1-x}Ga{sub x} (x {<=} 0.5), ErCu{sub 2-x}Ga{sub x} (x {<=} 1.1), ErCu{sub 5-x}Ga{sub x} (x {<=} 0.5), Er{sub 5}Cu{sub x}Ga{sub 3-x} (x {<=} 0.60), Er{sub 3}Cu{sub x}Ga{sub 2-x} (x {<=} 0.24), ErCu{sub x}Ga{sub 1-x} (x {<=} 0.10), ErCu{sub x}Ga{sub 2-x} (x {<=} 0.30) and ErCu{sub x}Ga{sub 3-x} (x {<=} 0.35), as well as six ternary intermediate phases, ErCu{sub x}Ga{sub 2-x} (0.4 {<=} x {<=} 0.7), Er{sub 14}Cu{sub 51-x}Ga{sub x} (5.5 {<=} x {<=} 11.0), ErCu{sub 5-x}Ga{sub x} (0.8 {<=} x {<=} 2.3), Er{sub 2}Cu{sub 17-x}Ga{sub x} (4.9 {<=} x {<=} 8.0), ErCu{sub 12-x}Ga{sub x} (5.7 {<=} x {<=} 6.7) and Er{sub 3}Cu{sub x}Ga{sub 11-x} (1.5 {<=} x {<=} 4.4), all deriving from binary structure-types.
Senior Sport er læring i virkeligheden
DEFF Research Database (Denmark)
Meyer, Erna Rosenlund
2014-01-01
Samarbejde mellem fysioterapeutudddannelsen på UCN og Aalborg senior Sport er givende for alle parter, inklusiv studerende.......Samarbejde mellem fysioterapeutudddannelsen på UCN og Aalborg senior Sport er givende for alle parter, inklusiv studerende....
Forvandling, fortælling og handling med mening
DEFF Research Database (Denmark)
Dupont, Søren
2015-01-01
Artiklen fokuserer på en række begreber og udviklinger hos Jerome Bruner og diskuterer de forskellige grundlag, som Jerome Bruner gennem tiderne har haft fokus på uden at noget grundlag på noget tidspunkt entydigt har været bestemmende. Jerome Bruner har bevæget sig fra at være orienteret mod...
Zebrafisken er et vigtigt forsøgsdyr
DEFF Research Database (Denmark)
Kjær-Sørensen, Kasper; Alstrup, Aage Kristian Olsen
2017-01-01
Det kan ved første øjekast undre, at en almindelig dansk akvariefisk er blevet forskernes favorit. Ikke desto mindre er det tilfældet for den lille zebrafisk (Danio rerio), som i disse år anvendes til at undersøge funktionen af gener, til at lave dyremodeller for menneskets sygdomme og til...
International Nuclear Information System (INIS)
Jafarzadeh, Hossein; Asadpour, Seyyed Hossein; Soleimani, H Rahimpour
2015-01-01
The effect of Er 3+ ion concentration and incoherent pumping field on the refractive index and group index in an Er 3+ : YAG crystal is investigated. It is shown that under different concentrations of Er 3+ ion in the crystal, the index of refraction and absorption can be changed and a high index of refraction is accompanied by amplification in the medium. Also, it is shown that with the switching from subluminal to superluminal, or vice versa, light propagation can be obtained by different concentrations of Er 3+ ions in the crystal. (paper)
Energy Technology Data Exchange (ETDEWEB)
Oswald, Iain W.H. [Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX 75080 (United States); Gourdon, Olivier [Research and Development, ZS Pharma, Coppell, TX 75109 (United States); Bekins, Amy; Evans, Jess [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019 (United States); Treadwell, LaRico J. [Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX 75080 (United States); Chan, Julia Y., E-mail: Julia.Chan@utdallas.edu [Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX 75080 (United States); Macaluso, Robin T., E-mail: robin.macaluso@uta.edu [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019 (United States); Department of Chemistry and Biochemistry, University of Northern Colorado, Greeley, CO 80639 (United States)
2016-10-15
Single crystals of Er{sub 1.33}Pt{sub 3}Ga{sub 8} were synthesized in a molten Ga flux. Er{sub 1.33}Pt{sub 3}Ga{sub 8} can be considered to be a modulated variant of the Er{sub 4}Pt{sub 9}Al{sub 24}-structure type, where the partial occupancies are ordered. Indeed, the presence of weak satellite reflections indicates a complex organization and distribution of the Er and Ga atoms within the [ErGa] slabs. The structure has been solved based on single crystal X-ray diffraction data in the monoclinic superspace group X2/m(0β0)00 with a commensurate modulated vector q=1/3b*. Precession images also indicate diffusion in the perpendicular direction indicating a partial disorder of this arrangement from layer to layer. In addition, Er{sub 1.33}Pt{sub 3}Ga{sub 8} shows antiferromagnetic ordering at T{sub N}~5 K. - Graphical abstract: A precession image of the hk0 zone showing weak, periodic, unindexed reflections indicating modulation and representation of the commensurate [ErGa] layer showing the waving modulated occupation. - Highlights: • Single crystals of Er{sub 1.33}Pt{sub 3}Ga{sub 8} were grown from gallium flux. • The structure of Er{sub 1.33}Pt{sub 3}Ga{sub 8} is compared to Er{sub 4}Pt{sub 9}Al{sub 24}. • Structure has been solved in the monoclinic superspace group X2/m(0β0)00 with a commensurate modulated vector q=1/3b*.
ER stress proteins in autoimmune and inflammatory diseases
Directory of Open Access Journals (Sweden)
Daisuke eMorito
2012-03-01
Full Text Available Over the past two decades, heat shock proteins (HSPs have been implicated in inflammatory responses and autoimmunity. HSPs were originally believed to maintain protein quality control in the cytosol. However, they also exist extracellularly and appear to act as inflammatory factors. Recently, a growing body of evidence suggested that the other class of stress proteins such as, endoplasmic reticulum (ER stress proteins, which originally act as protein quality control factors in the secretory pathway and are induced by ER stress in inflammatory lesions, also participate in inflammation and autoimmunity. The immunoglobulin heavy-chain binding protein (Bip/glucose-regulated protein 78 (Grp78, homocysteine-induced ER protein (Herp, calnexin, calreticulin, glucose-regulated protein 94 (Grp94/gp96, oxygen-regulated protein 150 (ORP150 and heat shock protein 47 (Hsp47/Serpin H1, which are expressed not only in the ER but also occasionally at the cell surface play pathophysiological roles in autoimmune and inflammatory diseases as pro- or anti-inflammatory factors. Here we describe the accumulating evidence of the participation of ER stress proteins in autoimmunity and inflammation and discuss the critical differences between the two classes of stress proteins.
On the Use of an ER-213 Detonator to Establish a Baseline for the ER-486
Energy Technology Data Exchange (ETDEWEB)
Thomas, Keith A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Liechty, Gary H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jaramillo, Dennis C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Munger, Alan C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); McHugh, Douglas C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kennedy, James E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2014-08-19
This report documents a series of tests using a TSD-115 fireset coupled with an ER-213, a gold exploding bridgewire (EBW) detonator. These tests were designed to fire this EBW with a smaller fireset to obtain current and voltage data as well as timing information at voltage levels below, above, and throughout the threshold firing region. This study could then create a database for comparison to our current ER-486 EBW development, which is designed to be a lower voltage (<500V) device.
Er det økologisk madordninger ofte sundere?
DEFF Research Database (Denmark)
He, Chen
Det europæiske skolemad system er under forandring, en forandring der er blevet kaldt den europæiske skolemad revolution af Morgan & Sonnino (2008). Forandringen består af to afgørende søjler/indsatsområder; 1) Krav til sundere kostvaner; 2) Flere økologiske fødevarer. Denne forskning harundersøg...
Danskhed er pizza, kebab og flæskesteg
DEFF Research Database (Denmark)
Mehlsen, Camilla
2010-01-01
Dannebrog. Kongehuset. Flæskesteg. Folkeskolen. Fodbold og øl. En lang række symboler og fortællinger kendetegner danskhed, men det er en myte, at danskerne er en homogen gruppe, fortæller professor Richard Jenkins....
SEC16 in COPII coat dynamics at ER exit sites
Sprangers, Joep; Rabouille, Catherine
Protein export from the endoplasmic reticulum (ER), the first step in protein transport through the secretory pathway, is mediated by coatomer protein II (COPII)-coated vesicles at ER exit sites. COPII coat assembly on the ER is well understood and the conserved large hydrophilic protein Sec16
DEFF Research Database (Denmark)
Hermansen, Judy
2008-01-01
Æstetiseringen af hverdagen er ét af de helt centrale træk ved det postmoderne forbrugersamfund. Og denne nedbrydning af grænserne mellem kunst og forbrug er det også vigtigt for marketingteorien at udforske. Artiklen analyserer to (kunst?)udstillinger i England, som på hver sin måde tematiserer,...
Behaviour of Er/sup 3 +/ ion in tetragonal crystalline field
Energy Technology Data Exchange (ETDEWEB)
Kumar, V; Dass, N; Chandra, K [Roorkee Univ. (India). Dept. of Physics
1976-12-01
Crystal field parameters for ErGaG and Er/sup 3 +/ YAlG are used to compute the temperature dependence of Schottky specific heat, paramagnetic susceptibility, magnetic anisotropy, sup(..mu..)eff and quadrupole splitting in the range 10-400 K. The hyperfine interaction parameters A and B for /sup 16/ /sup 166/Er and /sup 167/Er in both the systems are also obtained and in turn used to estimate the nuclear specific heat contribution. The studied parameters compare well with the available experimental results.
Self-assembled infrared-luminescent Er-Si-O crystallites on silicon
International Nuclear Information System (INIS)
Isshiki, H.; Dood, M.J.A. de; Polman, A.; Kimura, T.
2004-01-01
Optically active and electrically excitable erbium complexes on silicon are made by wet-chemical synthesis. The single-crystalline Er-Si-O compound is formed by coating a Si(100) substrate with an ErCl 3 /ethanol solution, followed by rapid thermal oxidation and annealing. Room-temperature Er-related 1.53 μm photoluminescence is observed with a peak linewidth as small as 4 meV. The complexes can be excited directly into the Er intra-4f states, or indirectly, through photocarriers. Er concentrations as high as 14 at. % are achieved, incorporated in a crystalline lattice with a 0.9 nm periodicity. Thermal quenching at room temperature is only a factor 5, and the lifetime at 1.535 μm is 200 μs
The ER in 3D: a multifunctional dynamic membrane network.
Friedman, Jonathan R; Voeltz, Gia K
2011-12-01
The endoplasmic reticulum (ER) is a large, singular, membrane-bound organelle that has an elaborate 3D structure with a diversity of structural domains. It contains regions that are flat and cisternal, ones that are highly curved and tubular, and others adapted to form contacts with nearly every other organelle and with the plasma membrane. The 3D structure of the ER is determined by both integral ER membrane proteins and by interactions with the cytoskeleton. In this review, we describe some of the factors that are known to regulate ER structure and discuss how this structural organization and the dynamic nature of the ER membrane network allow it to perform its many different functions. Copyright © 2011 Elsevier Ltd. All rights reserved.
Magnetocaloric effect in textured rare earth intermetallic compound ErNi
Directory of Open Access Journals (Sweden)
Aparna Sankar
2018-05-01
Full Text Available Melt-spun ErNi crystallizes in orthorhombic FeB-type structure (Space group Pnma, no. 62 similar to the arc-melted ErNi compound. Room temperature X-ray diffraction (XRD experiments reveal the presence of texture and preferred crystal orientation in the melt-spun ErNi. The XRD data obtained from the free surface of the melt-spun ErNi show large intensity enhancement for (1 0 2 Bragg reflection. The scanning electron microscopy image of the free surface depicts a granular microstructure with grains of ∼1 μm size. The arc-melted and the melt-spun ErNi compounds order ferromagnetically at 11 K and 10 K (TC respectively. Field dependent magnetization (M-H at 2 K shows saturation behaviour and the saturation magnetization value is 7.2 μB/f.u. for the arc-melted ErNi and 7.4 μB/f.u. for the melt-spun ErNi. The isothermal magnetic entropy change (ΔSm close to TC has been calculated from the M-H data. The maximum isothermal magnetic entropy change, -ΔSmmax, is ∼27 Jkg-1K-1 and ∼24 Jkg-1K-1 for the arc-melted and melt-spun ErNi for 50 kOe field change, near TC. The corresponding relative cooling power values are ∼440 J/kg and ∼432 J/kg respectively. Although a part of ΔSm is lost to crystalline electric field (CEF effects, the magnetocaloric effect is substantially large at 10 K, thus rendering melt-spun ErNi to be useful in low temperature magnetic refrigeration applications such as helium gas liquefaction.
Magnetocaloric effect in textured rare earth intermetallic compound ErNi
Sankar, Aparna; Chelvane, J. Arout; Morozkin, A. V.; Nigam, A. K.; Quezado, S.; Malik, S. K.; Nirmala, R.
2018-05-01
Melt-spun ErNi crystallizes in orthorhombic FeB-type structure (Space group Pnma, no. 62) similar to the arc-melted ErNi compound. Room temperature X-ray diffraction (XRD) experiments reveal the presence of texture and preferred crystal orientation in the melt-spun ErNi. The XRD data obtained from the free surface of the melt-spun ErNi show large intensity enhancement for (1 0 2) Bragg reflection. The scanning electron microscopy image of the free surface depicts a granular microstructure with grains of ˜1 μm size. The arc-melted and the melt-spun ErNi compounds order ferromagnetically at 11 K and 10 K (TC) respectively. Field dependent magnetization (M-H) at 2 K shows saturation behaviour and the saturation magnetization value is 7.2 μB/f.u. for the arc-melted ErNi and 7.4 μB/f.u. for the melt-spun ErNi. The isothermal magnetic entropy change (ΔSm) close to TC has been calculated from the M-H data. The maximum isothermal magnetic entropy change, -ΔSmmax, is ˜27 Jkg-1K-1 and ˜24 Jkg-1K-1 for the arc-melted and melt-spun ErNi for 50 kOe field change, near TC. The corresponding relative cooling power values are ˜440 J/kg and ˜432 J/kg respectively. Although a part of ΔSm is lost to crystalline electric field (CEF) effects, the magnetocaloric effect is substantially large at 10 K, thus rendering melt-spun ErNi to be useful in low temperature magnetic refrigeration applications such as helium gas liquefaction.
Energy Technology Data Exchange (ETDEWEB)
Tran, Thi Kim Anh [School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308 (Australia); Department of Agriculture, Forestry and Fisheries, Vinh University, 182 Le Duan St., Vinh City, Nghe An (Viet Nam); MacFarlane, Geoff R. [School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308 (Australia); Kong, Richard Yuen Chong [Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong Special Administrative Region (China); O’Connor, Wayne A. [New South Wales Department of Primary Industries, Port Stephens Fisheries Institute, Taylors Beach, NSW 2316 (Australia); Yu, Richard Man Kit, E-mail: Richard.Yu@newcastle.edu.au [School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308 (Australia)
2016-10-15
Highlights: • This is the first report on the putative promoter sequence of a molluscan ER gene. • The gene promoter contains putative binding sites for direct and indirect interaction with ER. • E2 upregulates ER gene expression in the ovary in vitro and in vivo. • E2-induced gene expression may require a novel ligand-dependent receptor. • The ER proximal promoter is hypomethylated regardless of gene expression levels. - Abstract: In vertebrates, estrogens and estrogen mimicking chemicals modulate gene expression mainly through a genomic pathway mediated by the estrogen receptors (ERs). Although the existence of an ER orthologue in the mollusc genome has been known for some time, its role in estrogen signalling has yet to be deciphered. This is largely due to its constitutive (ligand-independent) activation and a limited mechanistic understanding of its regulation. To fill this knowledge gap, we cloned and characterised an ER cDNA (sgER) and the 5′-flanking region of the gene from the Sydney rock oyster Saccostrea glomerata. The sgER cDNA is predicted to encode a 477-amino acid protein that contains a DNA-binding domain (DBD) and a ligand-binding domain (LBD) typically conserved among both vertebrate and invertebrate ERs. A comparison of the sgER LBD sequence with those of other ligand-dependent ERs revealed that the sgER LBD is variable at several conserved residues known to be critical for ligand binding and receptor activation. Ligand binding assays using fluorescent-labelled E2 and purified sgER protein confirmed that sgER is devoid of estrogen binding. In silico analysis of the sgER 5′-flanking sequence indicated the presence of three putative estrogen responsive element (ERE) half-sites and several putative sites for ER-interacting transcription factors, suggesting that the sgER promoter may be autoregulated by its own gene product. sgER mRNA is ubiquitously expressed in adult oyster tissues, with the highest expression found in the ovary
Chen, Fa-Hsyang; Her, Jim-Long; Shao, Yu-Hsuan; Matsuda, Yasuhiro H; Pan, Tung-Ming
2013-01-08
In this letter, we investigated the structural and electrical characteristics of high-κ Er2O3 and Er2TiO5 gate dielectrics on the amorphous indium-gallium-zinc-oxide (a-IGZO) thin-film transistor (TFT) devices. Compared with the Er2O3 dielectric, the a-IGZO TFT device incorporating an Er2TiO5 gate dielectric exhibited a low threshold voltage of 0.39 V, a high field-effect mobility of 8.8 cm2/Vs, a small subthreshold swing of 143 mV/decade, and a high Ion/Ioff current ratio of 4.23 × 107, presumably because of the reduction in the oxygen vacancies and the formation of the smooth surface roughness as a result of the incorporation of Ti into the Er2TiO5 film. Furthermore, the reliability of voltage stress can be improved using an Er2TiO5 gate dielectric.
Analysis of erythema after Er:YAG laser skin resurfacing.
Ko, Na Young; Ahn, Hyo-Hyun; Kim, Soo-Nam; Kye, Young-Chul
2007-11-01
Postoperative erythema can be expected to occur in every patient after laser resurfacing, and pigmentary disturbances may be related to the intensity and the duration of erythema. This study was undertaken to assess the clinical features of erythema, the factors that influence its duration, and the relation between the duration of erythema and the incidence of hyperpigmentation and hypopigmentation in skin of Asian persons after Er:YAG laser resurfacing. A total of 218 patients (skin phototypes III to V) were recruited and treated with a short-pulsed Er:YAG laser, a variable-pulsed Er:YAG laser, or a dual-mode Er:YAG laser for skin resurfacing. Clinical assessments were performed retrospectively using medical charts and serial photographs. Postoperative erythema was observed in all patients after Er:YAG laser resurfacing with a mean duration of 4.72 months. In 98.2% of patients, erythema faded completely within 12 months. Postinflammatory hyperpigmentation was observed in 38.1% of patients after Er:YAG laser resurfacing. Skin phototype, level of ablation, and depth of thermal damage caused by a long-pulsed laser appear to be important factors that affect the duration of erythema. Moreover, prolonged erythema was related to the risk of postinflammatory hyperpigmentation.
DEFF Research Database (Denmark)
Hoffmeyer, Jesper
2011-01-01
En computer er i sig selv blot et stykke mekanik. Det afgørende sker i mødet mellem maskinen, mennesker og fællesskaber: på grænsefladen. Præcis som hos levende væsner......En computer er i sig selv blot et stykke mekanik. Det afgørende sker i mødet mellem maskinen, mennesker og fællesskaber: på grænsefladen. Præcis som hos levende væsner...
Outdoor Adventure er mulighedernes læringslandskab
DEFF Research Database (Denmark)
Pedersen, Sune Ib Schou
2014-01-01
Global Nutrition and Health er en ny international uddannelse for ernærings- og sundhedsstuderende ved Professionshøjskolen Metropol. De tilbydes Outdoor Adventure, som bryder de vante rammer for undervisning.......Global Nutrition and Health er en ny international uddannelse for ernærings- og sundhedsstuderende ved Professionshøjskolen Metropol. De tilbydes Outdoor Adventure, som bryder de vante rammer for undervisning....
Outdoor Adventure er mulighedernes læringslandskab
DEFF Research Database (Denmark)
Pedersen, Sune
2015-01-01
Global Nutrition and Health er en ny international uddannelse for ernærings- og sundhedsstuderende ved Professionshøjskolen Metropol. De tilbydes Outdoor Adventure, som bryder de vante rammer for undervisning.......Global Nutrition and Health er en ny international uddannelse for ernærings- og sundhedsstuderende ved Professionshøjskolen Metropol. De tilbydes Outdoor Adventure, som bryder de vante rammer for undervisning....
En isoleret verden er en bedre verden
DEFF Research Database (Denmark)
Enrum, Nils
2014-01-01
Man skal ikke kaste med sten, hvis man bor i et hus med energimærke D ... Men problemet med varmetab fra danske boliger er til at løse......Man skal ikke kaste med sten, hvis man bor i et hus med energimærke D ... Men problemet med varmetab fra danske boliger er til at løse...
At Forstå et Moderne Digt/To Understand a Modern Poem
DEFF Research Database (Denmark)
Schatz-Jakobsen, Claus
1998-01-01
Artiklen plæderer for at det at 'forstå et moderne digt' betyder noget radikalt andet nu end det gjorde for halvtreds år siden, da William Empson under overskriften 'To Understand a Modern Poem' udlagde et digt af Dylan Thomas - noget radikalt andet, både hvad angår 'det at forstå' og hvad angår...
Fluorescence lifetime imaging of microviscosity changes during ER autophagy in live cells
He, Ying; Samanta, Soham; Gong, Wanjun; Liu, Wufan; Pan, Wenhui; Yang, Zhigang; Qu, Junle
2018-02-01
Unfolded or misfolded protein accumulation inside Endoplasmic Reticulum (ER) will cause ER stress and subsequently will activate cellular autophagy to release ER stress, which would ultimately result in microviscosity changes. However, even though, it is highly significant to gain a quantitative assessment of microviscosity changes during ER autophagy to study ER stress and autophagy behaviors related diseases, it has rarely been reported yet. In this work, we have reported a BODIPY based fluorescent molecular rotor that can covalently bind with vicinal dithiols containing nascent proteins in ER and hence can result in ER stress through the inhibition of the folding of nascent proteins. The change in local viscosity, caused by the release of the stress in cells through autophagy, was quantified by the probe using fluorescence lifetime imaging. This work basically demonstrates the possibility of introducing synthetic chemical probe as a promising tool to diagnose ER-viscosity-related diseases.
Hvordan kan jeg ane det jeg gør er rigtigt?
DEFF Research Database (Denmark)
Petersen, Anders
2014-01-01
Dømmekraft er i vælten. Men hvad er dømmekraft, og hvordan er det muligt at udvikle sin dømmekraft i en virkelighed, hvor målstyring fylder stadigt mere? Artiklen tager med dømmekraftbegrebet afsæt i den nye pædagoguddannelse. Bekendtgørelsen er præget af en opfordring til at have mere opmærksomh...
DEFF Research Database (Denmark)
Svømmekjær, Heidi Frank
2012-01-01
Katalog til udstillingen "Det man hører, er man selv" på Mediemuseet i Odense 7. september 2012 - 15. januar 2013.......Katalog til udstillingen "Det man hører, er man selv" på Mediemuseet i Odense 7. september 2012 - 15. januar 2013....
Directory of Open Access Journals (Sweden)
Hasan Çoruk
2017-04-01
Full Text Available This study aimed to investigate the effect of multimedia material covering 4th grade mathematics course fractions topic on students’ academic achievement levels, math anxiety, computer anxiety levels and thoughts on multimedia. A quasi-experimental design with pre-test - post-test and control group was conducted. The study was carried out with 31 students in each group: 13 male and 18 female students in the experimental group and 12 male and 19 female students in the control group. “Fractions Achievement Test”, “Mathematics Anxiety Scale”, “Computer Anxiety Scale”, and “Interview Form” were used as data collection tools. It was concluded that multimedia applications were more effective than traditional teaching methods in terms of improving academic achievement. According to the math anxiety data, neither multimedia applications nor traditional teaching methods were effective in relieving math anxiety of the students. The anxiety existing before the study was significantly reduced. The analysis of the interview forms indicated that multimedia applications helped students in some areas such as effective presentation, revising the subjects, increasing the interest in the course and providing a fun study environment. Multimedia applications were recommended to be used effectively in other courses as well in terms of lesson presentation, course revision and educational games. [Bu çalışmanın amacı 4. sınıf matematik dersi kesirler konusunda hazırlanan çoklu ortamların öğrencilerin akademik başarı düzeylerine, matematik kaygı düzeylerine, bilgisayar kaygı düzeylerine ve çoklu ortamlar hakkında düşüncelerine etkisini araştırmaktır. Araştırmada ön test - son test kontrol gruplu yarı deneysel desen kullanılmıştır. Deney grubunda 13 erkek ve 18 kız, kontrol grubunda da 12 erkek ve 19 kız olmak üzere 31’er öğrenci ile çalışma tamamlanmıştır. Veri toplama araçları olarak “Kesirler Konusu
Optimum Er concentration for in situ doped GaN visible and infrared luminescence
International Nuclear Information System (INIS)
Lee, D. S.; Heikenfeld, J.; Steckl, A. J.; Hommerich, U.; Seo, J. T.; Braud, A.; Zavada, J.
2001-01-01
GaN thin films have been doped with varying Er concentrations (0.01--10 at.%) during molecular-beam-epitaxy growth. As expected, the visible and infrared (IR) emissions, from photoluminescence (PL) and electroluminescence (EL), are a strong function of Er concentration. We report on the determination of an optimum Er doping level for PL and EL intensity. Secondary ion mass spectroscopy and Rutherford backscattering measurements showed that the Er concentration in GaN increased exponentially with Er cell temperature. PL and EL intensity of green emission at 537 and 558 nm, due to Er 4f--4f inner shell transitions, exhibited a maximum at ∼1 at.% Er. IR PL intensity at 1.54 μm, due to another Er transition, revealed the same maximum for ∼1 at.% Er concentration. PL lifetime measurements at 537 nm showed that samples with Er concentration <1 at.% had a lifetime of ∼5 μs. For Er concentration ≥1 at.%, the lifetime decreased rapidly to values below 1 μs. This concentration quenching is believed to be due to a combination of Er cross relaxation and energy transfer to GaN defects, eventually followed by precipitation. This conclusion is supported by x-ray diffraction measurements. As a result, we have determined that the optimum Er doping concentration into GaN is ∼1 at.%. Copyright 2001 American Institute of Physics
Isothermal section of the Er-Fe-Al ternary system at 800 oC
International Nuclear Information System (INIS)
Jemmali, M.; Walha, S.; Pasturel, M.; Tougait, O.; Ben Hassen, R.; Noel, H.
2010-01-01
Physico-chemical analysis techniques, including X-ray diffraction and Scanning Electron Microscope-Energy Dispersive X-ray Spectroscopy, were employed to construct the isothermal section of the Er-Fe-Al system at 800 o C. At this temperature, the phase diagram is characterized by the formation of five intermediate phases, ErFe 12-x Al x with 5 ≤ x ≤ 8 (ThMn 12 -type), ErFe 1+x Al 1-x with -0.2 ≤ x ≤ 0.75 (MgZn 2 -type), ErFe 3-x Al x with 0.5 2 Al-type), Er 2 Fe 17-x Al x with 4.74 ≤ x ≤ 5.7 (TbCu 7 -type) and Er 2 Fe 17-x Al x with 5.7 2 Zn 17 -type), seven extensions of binaries into the ternary system; ErFe x Al 3-x with x 3 Cu-type), ErFe x Al 2-x with x ≤ 0.68 (MgCu 2 -type), Er 2 Fe x Al 1-x with x ≤ 0.25 (Co 2 Si-type), ErFe 2-x Al x with x ≤ 0.5 (MgCu 2 -type), ErFe 3-x Al x with x ≤ 0.5 (Be 3 Nb-type), Er 6 Fe 23-x Al x with x ≤ 8 (Th 6 Mn 23 -type), and Er 2 Fe 17-x Al x with x ≤ 4.75 (Th 2 Ni 17 -type) and one intermetallic compound; the ErFe 2 Al 10 (YbFe 2 Al 10 -type).
Er Native Advertising en gråzone?
DEFF Research Database (Denmark)
Andersen, Lars Pynt
2018-01-01
Native advertising ser ud til at være den perfekte syntese mellem læsernes ønske om interessant indhold og annoncørers ønske om at komme tættere på kunderne. Men native advertising er også anklaget for at være fundamentalt uetisk i sin virkemåde, og måske er de gode oplevelser faktisk netop et...
Measuring the Digital Divide with PingER
Energy Technology Data Exchange (ETDEWEB)
Cottrell, L.
2003-10-01
We introduce the PingER project/toolkit and show its relevance to monitoring sites in developing countries. We then show results from PingER that illustrate the extent of the Digital Divide in terms of Internet performance between developed and developing regions, which developing regions are catching up, keeping up, or falling behind and the magnitude of the differences in performance between developed regions and developing regions.
Temperature Effects of Dielectric Properties of ER Fluids
Qiu, Z. Y.; Hu, L.; Liu, M. W.; Bao, H. X.; Jiang, Y. G.; Zhou, L. W.; Tang, Y.; Gao, Z.; Sun, M.; Korobko, E. V.
Under the consideration of the role that energy transfer and dissipation play in ER effect, an improved theory frame for ER effects, polarization-dissipation-structure-rheology, is suggested. The theory frame is substantiated by the basic physical laws and certain critical experimental facts. The dielectric response of a diatomite ER fluid to temperature is measured in the temperature range of 140 K to 400 K. By comparison of the DC conductivity with the AC effective conductivity of the sample, we found that the AC dielectric loss consists of two parts. One part comes from the DC conductivity, the other from the response of the bound charges in scope of particle to AC field. It is suggested that the response of bound charges is very important to ER effects. Besides, the effect of temperature on shear stress is measured, and interpreted based on the dielectric measurements. The source of two loss peaks in the curve of the dielectric loss versus temperature is not clear.
Energy Technology Data Exchange (ETDEWEB)
Almeida, José Manuel Marques Martins de, E-mail: jmmma@utad.pt [INESC-TEC, Rua do Campo Alegre, 687, Porto 4169-007 (Portugal); Department of Physics, School of Science and Technology, University of Trás-os-Montes e Alto Douro, PO. Box 1013, 5001-801 Vila Real (Portugal); Sada, Cinzia [Dipartimento di Fisica e Astronomia G. Galilei, Università di Padova, Via Marzolo 8, 35131 Padova (Italy)
2016-02-15
Highlights: • Enhancement of the diffusion of erbium ions (Er{sup 3+}) in lithium niobate crystals. • Incoherence on published results lead to need for systematic revision of literature. • Further insight into the topic of co-diffusion of Er{sup 3+}/Ti{sup 4+} ions into LiNbO{sub 3}. - Abstract: After carrying out a revision of the literature on the enhancement of Er{sup 3+} diffusion in LiNbO{sub 3} crystals by Er{sup 3+}/Ti{sup 4+} co-diffusion and analyzing our own experimental results, we conclude that no reproducible results were reported, meaning that further research on this subject is necessary.
Enhanced magnetodielectric and multiferroic properties of Er-doped bismuth ferrite nanoparticles
Energy Technology Data Exchange (ETDEWEB)
Mukherjee, A.; Banerjee, M. [Department of Physics, National Institute of Technology, Durgapur 713209 (India); Basu, S., E-mail: soumen.basu@phy.nitdgp.ac.in [Department of Physics, National Institute of Technology, Durgapur 713209 (India); Mukadam, M.D.; Yusuf, S.M. [Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Pal, M. [CSIR-Central Glass & Ceramic Research Institute, Kolkata 700032 (India)
2015-07-15
An enhancement in multiferroic properties has been achieved for chemically prepared BFO nanoparticles by doping with erbium (Er). XRD along with electron microscopy study reveals the phase purity and nanocrystalline nature of BFO. Enhancement of both the magnetic moment and resistivity is observed by virtue of Er doping. The observed enhanced magnetic moment is considered to be associated with smaller crystallite whereas increase of resistivity may be attributed to a decrease of oxygen vacancies. Doping also display an improvement of leakage behaviour and dielectric constant in nanocrystalline BFO, reflected in well-developed P-E loop. In addition, large enhancement in magnetodielectric coefficient is observed because of Er doping. Therefore, the results provide interesting approaches to improve the multiferroic properties of BFO, which has great implication towards its applications. - Highlights: • Synthesis of pure Er-doped BFO nanoparticles by chemical route. • Large increase in magnetic moment and resistivity due to Er doping. • Er doping produce well developed P-E loop and enhance polarization. • Drastic increase in dielectric constant as well as magnetodielectric coefficient observes because of Er doping.
Aging induced ER stress alters sleep and sleep homeostasis
Brown, Marishka K.; Chan, May T.; Zimmerman, John E.; Pack, Allan I.; Jackson, Nicholas E.; Naidoo, Nirinjini
2014-01-01
Alterations in the quality, quantity and architecture of baseline and recovery sleep have been shown to occur during aging. Sleep deprivation induces endoplasmic reticular (ER) stress and upregulates a protective signaling pathway termed the unfolded protein response (UPR). The effectiveness of the adaptive UPR is diminished by age. Previously, we showed that endogenous chaperone levels altered recovery sleep in Drosophila melanogaster. We now report that acute administration of the chemical chaperone sodium 4-phenylbutyrate (PBA) reduces ER stress and ameliorates age-associated sleep changes in Drosophila. PBA consolidates both baseline and recovery sleep in aging flies. The behavioral modifications of PBA are linked to its suppression of ER stress. PBA decreased splicing of x-box binding protein 1 (XBP1) and upregulation of phosphorylated elongation initiation factor 2 α (p-eIF2α), in flies that were subjected to sleep deprivation. We also demonstrate that directly activating ER stress in young flies fragments baseline sleep and alters recovery sleep. Alleviating prolonged/sustained ER stress during aging contributes to sleep consolidation and improves recovery sleep/ sleep debt discharge. PMID:24444805
CAMEX-4 ER-2 HIGH ALTITUDE DROPSONDE V1
National Aeronautics and Space Administration — The CAMEX-4 ER-2 High Altitude Dropsonde dataset was collected by the ER-2 High Altitude Dropsonde System (EHAD), which used dropwinsondes fitted with Global...
International Nuclear Information System (INIS)
Russell, C.E.; Gillespie, D.; Cole, J.C.; Drellack, S.L.
1996-12-01
The objective of drillhole ER-12-1 was to determine the hydrogeology of paleozoic carbonate rocks and of the Eleana Formation, a regional aquitard, in an area potentially downgradient from underground nuclear testing conducted in nearby Rainier Mesa. This objective was addressed through the drilling of well ER-12-1 at N886,640.26 E640,538.85 Nevada Central Coordinates. Drilling of the 1094 m (3588 ft) well began on July 19, 1991 and was completed on October 17, 1991. Drilling problems included hole deviation and hole instability that prevented the timely completion of this borehole. Drilling methods used include rotary tri-cone and rotary hammer drilling with conventional and reverse circulation using air/water, air/foam (Davis mix), and bentonite mud. Geologic cuttings and geophysical logs were obtained from the well. The rocks penetrated by the ER-12-1 drillhole are a complex assemblage of Silurian, Devonian, and Mississippian sedimentary rocks that are bounded by numerous faults that show substantial stratigraphic offset. The final 7.3 m (24 ft) of this hole penetrated an unusual intrusive rock of Cretaceous age. The geology of this borehole was substantially different from that expected, with the Tongue Wash Fault encountered at a much shallower depth, paleozoic rocks shuffled out of stratigraphic sequence, and the presence of an altered biotite-rich microporphyritic igneous rock at the bottom of the borehole. Conodont CAI analyses and rock pyrolysis analyses indicate that the carbonate rocks in ER-12-1, as well as the intervening sheets of Eleana siltstone, have been thermally overprinted following movement on the faults that separate them. The probable source of heat for this thermal disturbance is the microporphyritic intrusion encountered at the bottom of the hole, and its age establishes that the major fault activity must have occurred prior to 102.3+0.5 Ma (middle Cretaceous)
Induction of ER stress in macrophages of tuberculosis granulomas.
Directory of Open Access Journals (Sweden)
Tracie A Seimon
2010-09-01
Full Text Available The endoplasmic reticulum (ER stress pathway known as the Unfolded Protein Response (UPR is an adaptive survival pathway that protects cells from the buildup of misfolded proteins, but under certain circumstances it can lead to apoptosis. ER stress has been causally associated with macrophage apoptosis in advanced atherosclerosis of mice and humans. Because atherosclerosis shares certain features with tuberculosis (TB with regard to lesional macrophage accumulation, foam cell formation, and apoptosis, we investigated if the ER stress pathway is activated during TB infection.Here we show that ER stress markers such as C/EBP homologous protein (CHOP; also known as GADD153, phosphorylated inositol-requiring enzyme 1 alpha (Ire1α and eukaryotic initiation factor 2 alpha (eIF2α, and activating transcription factor 3 (ATF3 are expressed in macrophage-rich areas of granulomas in lungs of mice infected with virulent Mycobacterium tuberculosis (Mtb. These areas were also positive for numerous apoptotic cells as assayed by TUNEL. Microarray analysis of human caseous TB granulomas isolated by laser capture microdissection reveal that 73% of genes involved in the UPR are upregulated at the mRNA transcript level. The expression of two ER stress markers, ATF3 and CHOP, were also increased in macrophages of human TB granulomas when assayed by immunohistochemistry. CHOP has been causally associated with ER stress-induced macrophage apoptosis. We found that apoptosis was more abundant in granulomas as compared to non-granulomatous tissue isolated from patients with pulmonary TB, and apoptosis correlated with CHOP expression in areas surrounding the centralized areas of caseation.In summary, ER stress is induced in macrophages of TB granulomas in areas where apoptotic cells accumulate in mice and humans. Although macrophage apoptosis is generally thought to be beneficial in initially protecting the host from Mtb infection, death of infected macrophages in
Energy Technology Data Exchange (ETDEWEB)
Gerald Heymsfield
2010-12-20
Data was taken with the NASA ER-2 aircraft with the Cloud Radar System and other instruments in conjunction with the DOE ARM CLASIC field campaign. The flights were near the SGP site in north Central Oklahoma and targeted small developing convection. The CRS is a 94 GHz nadir pointing Doppler radar. Also on board the ER-2 was the Cloud Physics Lidar (CPL). Seven science flights were conducted but the weather conditions did not cooperate in that there was neither developing convection, or there was heavy rain.
Harvard ER-2 OH laser-induced fluorescence instrument
Wennberg, Paul O.; Anderson, James G.
1994-01-01
The Harvard ER-2 OH instrument is scheduled to be integrated into the NASA ER-2 high altitude aircraft ozone payload in August 1992. Design and fabrication is presently underway. This experiment is a descendant of a balloon borne instrument designed and built in the mid-1980s. The ER-2 instrument is being designed to measure OH and HO2 as part of the NASA ozone payload for the investigation of processes controlling the concentration of stratospheric ozone. Although not specifically designed to do so, it is hoped that valid measurements of OH and HO2 can be made in the remote free troposphere with this instrument.
Computational modelling of Er(3+): Garnet laser materials
Spangler, Lee H.
1994-01-01
The Er(3+) ion has attracted a lot of interest for four reasons: (1) Its (4)I(sub 13/2) yields (4)I(sub 15/2) transition lases in the eyesafe region near 1.5 micron; (2) the (4)I(sub 13/2) transition lases near 2.8 micron, an important wavelength for surgical purposes; (3) it displays surprisingly efficient upconversion with lasing observed at 1.7, 1.2, 0.85, 0.56, 0.55, and 0.47 micron following 1.5 micron pumping; and (4) it has absorption bands at 0.96 and 0.81 micron and thus can be diode pumped. However, properties desirable for upconversion reduce the efficiency of 1.5 and 3 micron laser operation and vice versa. Since all of the processes are influenced by the host via the crystal field induced stark splittings in the Er levels, this project undertook modelling of the host influence on the Er lasinng behavior. While growth and measurement of all ten Er(3+) doped garnets is the surest way of identifying hosts which maximize upconversion (or conversly, 1.5 and 3 micron performance), it is also expensive - costing approximately $10,000/material or approximately $100,000 for the materials computationally investigated here. The calculations were performed using a quantum mechanical point charge model developed by Clyde Morrison at Harry Diamond Laboratories. The programs were used to fit the Er:YAG experimental energy levels so that the crystal field parameters, B(sub nm) could be extracted. From these radial factors, rho (sub n) were determined for Er(3+) in garnets. These, in combination with crystal field components, Anm, available from X-ray data, were used to predict energy levels for Er in the other nine garnet hosts. The levels in Er:YAG were fit with an rms error of 12.2/cm over a 22,000/cm range. Predicted levels for two other garnets for which literature values were available had rms errors of less than 17/cm , showing the calculations to be reliable. Based on resonances between pairs of calculated stark levels, the model predicts GSGG as the best host
DEFF Research Database (Denmark)
Hokland, Peter
2017-01-01
Amerikanske hæmatologer og hæmatopatologer har udarbejdet en ny guideline, der skal forbedre diagnosticeringen og dermed behandlingen af akut anæmi, De er på linje med, hvad de hæmatologiske afdelinger allerede gør i Danmark, hvor man arbejder tæt sammen og følger samme protokol. Og kvaliteten er...
Lundstrøm Jørgensen, Mette; Buje Christensen, Stine; Lund Christiansen, Trine
2009-01-01
In this thesis we focus on how prison staff can improve their communication skills when educating the inmates. We use the state prison of Møgelkær as a case study. In this prison the staff has created a System for Guidance and Clarification of Competences (named VOKS), which seeks to increase the number of inmates getting an education whilst serving their sentence. Based on qualitative interviews with inmates and staff plus observations in the prison, we examine how the staff can implement a ...
DEFF Research Database (Denmark)
Birkholm, Klavs
2016-01-01
I sin bog om den amerikanske "neuropsykiater" Robert Heath (1915-99) demonstrerer videnskabsjournalisten Lone Frank nok engang sin forbundethed med den internationale transhumanisme og dens dualistiske forståelse af ånd og materie......I sin bog om den amerikanske "neuropsykiater" Robert Heath (1915-99) demonstrerer videnskabsjournalisten Lone Frank nok engang sin forbundethed med den internationale transhumanisme og dens dualistiske forståelse af ånd og materie...
DEFF Research Database (Denmark)
Andersen, Svend
2014-01-01
Tendensen i dansk universitetspolitik diskuteres kritisk i lyset af Wilhelm von Humboldt og K.E. Løgstrups tanker.......Tendensen i dansk universitetspolitik diskuteres kritisk i lyset af Wilhelm von Humboldt og K.E. Løgstrups tanker....
Modeller forudsiger klimarespons hos træer og buske
DEFF Research Database (Denmark)
Meilby, Henrik
2015-01-01
Modeller baseret på målinger af træer og buskes årringe afslører, hvilke klimatiske faktorer der lokalt er afgørende for deres vækst. Det kan hjælpe os med at forstå nogle af de ændringer, der sker i vegetationen, for eksempel i Grønland og i alpine områder. Med udgangspunkt i klimafrem- skrivnin......Modeller baseret på målinger af træer og buskes årringe afslører, hvilke klimatiske faktorer der lokalt er afgørende for deres vækst. Det kan hjælpe os med at forstå nogle af de ændringer, der sker i vegetationen, for eksempel i Grønland og i alpine områder. Med udgangspunkt i klimafrem...
Visible and infrared photoluminescence from Er-doped SiOx
International Nuclear Information System (INIS)
Wan, J.; Sheng, C.; Lu, F.; Yuan, S.; Gong, D.W.; Liao, L.S.; Fang, Y.L.; Lin, F.; Wang, X.
1998-01-01
The annealing behaviors of photoluminescence of SiO x and Er-doped SiO x grown by molecular beam epitaxy in the wavelength range of visible and infrared light are studied. For SiO x , four PL bands located at 510, 600, 716 and 810 nm, respectively, are observed. For Er-doped SiO x , the 716 nm band, which is believed to be originated from the electron-hole recombination at the interface between crystalline Si and amorphous SiO 2 , disappears in the annealing temperature range of 500-900C. It is suggested the enhancement of Er luminescence is partially due to the energy transfer from the recombination at the interface between crystalline Si and SiO 2 to Er ions. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)
Excitation mechanism of Er{sup 3+} in a-Si:H; Anregungsmechanismus von Er{sup 3+} in a-Si:H
Energy Technology Data Exchange (ETDEWEB)
Kuehne, H.
2004-07-01
The aim of this work is the examination of the optoelectronical material a-Si:H (Er). It is characterised in the good electronic properties of the a-Si:H and the emission wavelength of 1.5 micrometer of erbium which coincides with the absorbtion minimum of glasfibres. Photoluminescence measurements confirm the assumption that oxigen is necessary for the optical activation of Er{sup 3+} in addition to the symmetrical breaking of the crystal field. The flexible lattice of a-Si:H enables a high concentration of Erbium up to 5.10{sup 21}/cm{sup 3} with a quantum efficiency of the luminescence of 0.5-1.5.10{sup -4} at room temperature. Photoluminescence excitation and absorption measurements of a-Si:H (Er) show, that there is no direct excitation of the erbium ions because the absorption of the Er{sup 3+} ions is two orders of magnitude below the absorption of silicon. The excitation or the Er{sup 3+} ions takes place through the absorption in silicon with additional energy transfer to Erbium. Photoluminescence measurements are done in order to differentiate between the possible excitation channels, the intrinsic bond-bond channel and the excitation through defects. The different temperature dependence of the intensity of the intrinsic luminescence (77 K - 300 K >3 orders of magnitude) in comparison with the defect luminescence and the Erbium luminescence (both 1-1.5 orders of magnitude) shows that the energy transfer takes place over defects. Luminescence and absorption measurements with boron doped a-Si:H (Er) show no dependence of the Erbium luminescence in dependence of defect density or the electrical charge of the defects. The luminescence spectra show a break in the defect luminescence at 0.84 eV. This agrees with the first excited state of the Er{sup 3+} ion combined with a clearly smaller line width of the defect luminescence (0.18 eV in comparision with >0.3 eV in erbium free a-Si:H). This result shows the resonance of the energy transfer. The resonance is
ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER.
Costello, Joseph L; Castro, Inês G; Hacker, Christian; Schrader, Tina A; Metz, Jeremy; Zeuschner, Dagmar; Azadi, Afsoon S; Godinho, Luis F; Costina, Victor; Findeisen, Peter; Manner, Andreas; Islinger, Markus; Schrader, Michael
2017-02-01
Peroxisomes (POs) and the endoplasmic reticulum (ER) cooperate in cellular lipid metabolism and form tight structural associations, which were first observed in ultrastructural studies decades ago. PO-ER associations have been suggested to impact on a diverse number of physiological processes, including lipid metabolism, phospholipid exchange, metabolite transport, signaling, and PO biogenesis. Despite their fundamental importance to cell metabolism, the mechanisms by which regions of the ER become tethered to POs are unknown, in particular in mammalian cells. Here, we identify the PO membrane protein acyl-coenzyme A-binding domain protein 5 (ACBD5) as a binding partner for the resident ER protein vesicle-associated membrane protein-associated protein B (VAPB). We show that ACBD5-VAPB interaction regulates PO-ER associations. Moreover, we demonstrate that loss of PO-ER association perturbs PO membrane expansion and increases PO movement. Our findings reveal the first molecular mechanism for establishing PO-ER associations in mammalian cells and report a new function for ACBD5 in PO-ER tethering. © 2017 Costello et al.
Enhancement of Er optical efficiency through bismuth sensitization in yttrium oxide
Energy Technology Data Exchange (ETDEWEB)
Scarangella, Adriana [CNR IMM-MATIS, Via S. Sofia 64, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, 95123 Catania (Italy); Reitano, Riccardo [Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, 95123 Catania (Italy); Franzò, Giorgia; Miritello, Maria, E-mail: maria.miritello@ct.infn.it [CNR IMM-MATIS, Via S. Sofia 64, 95123 Catania (Italy); Priolo, Francesco [CNR IMM-MATIS, Via S. Sofia 64, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, 95123 Catania (Italy); Scuola Superiore di Catania, Università di Catania, Via Valdisavoia 9, 95123 Catania (Italy)
2015-07-27
The process of energy transfer (ET) between optically active ions has been widely studied to improve the optical efficiency of a system for different applications, from lighting and photovoltaics to silicon microphotonics. In this work, we report the influence of Bi on the Er optical emission in erbium-yttrium oxide thin films synthesized by magnetron co-sputtering. We demonstrate that this host permits to well dissolve Er and Bi ions, avoiding their clustering, and thus to stabilize the optically active Er{sup 3+} and Bi{sup 3+} valence states. In addition, we establish the ET occurrence from Bi{sup 3+} to Er{sup 3+} by the observed Bi{sup 3+} PL emission decrease and the simultaneous Er{sup 3+} photoluminescence (PL) emission increase. This was further confirmed by the coincidence of the Er{sup 3+} and Bi{sup 3+} excitation bands, analyzed by PL excitation spectroscopy. By increasing the Bi content of two orders of magnitude inside the host, though the occurrence of Bi-Bi interactions becomes deleterious for Bi{sup 3+} optical efficiency, the ET process between Bi{sup 3+} and Er{sup 3+} is still prevalent. We estimate ET efficiency of 70% for the optimized Bi:Er ratio equal to 1:3. Moreover, we have demonstrated to enhance the Er{sup 3+} effective excitation cross section by more than three orders of magnitude with respect to the direct one, estimating a value of 5.3 × 10{sup −18} cm{sup 2}, similar to the expected Bi{sup 3+} excitation cross section. This value is one of the highest obtained for Er in Si compatible hosts. These results make this material very promising as an efficient emitter for Si-compatible photonics devices.
A model for the generation and interconversion of ER morphologies.
Shemesh, Tom; Klemm, Robin W; Romano, Fabian B; Wang, Songyu; Vaughan, Joshua; Zhuang, Xiaowei; Tukachinsky, Hanna; Kozlov, Michael M; Rapoport, Tom A
2014-12-09
The peripheral endoplasmic reticulum (ER) forms different morphologies composed of tubules and sheets. Proteins such as the reticulons shape the ER by stabilizing the high membrane curvature in cross-sections of tubules and sheet edges. Here, we show that membrane curvature along the edge lines is also critical for ER shaping. We describe a theoretical model that explains virtually all observed ER morphologies. The model is based on two types of curvature-stabilizing proteins that generate either straight or negatively curved edge lines (R- and S-type proteins). Dependent on the concentrations of R- and S-type proteins, membrane morphologies can be generated that consist of tubules, sheets, sheet fenestrations, and sheet stacks with helicoidal connections. We propose that reticulons 4a/b are representatives of R-type proteins that favor tubules and outer edges of sheets. Lunapark is an example of S-type proteins that promote junctions between tubules and sheets. In a tubular ER network, lunapark stabilizes three-way junctions, i.e., small triangular sheets with concave edges. The model agrees with experimental observations and explains how curvature-stabilizing proteins determine ER morphology.
Fabrication of Gamma Detectors Based on Magnetic Ag:Er Microcalorimeters
Energy Technology Data Exchange (ETDEWEB)
Friedrich, Stephan [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Boyd, Stephen [Univ. of New Mexico, Albuquerque, NM (United States); Cantor, Robin [STAR Cryoelectronics, Santa Fe, NM (United States)
2015-11-25
This report discusses the photolithographic fabrication of ultra-high resolution gamma-ray detectors based on magnetic microcalorimeters (MMCs). The MMC uses a novel Er-doped silver sensor (Ag:Er) that is expected to have higher sensitivity than the Er-doped gold (Au:Er) sensors currently in use. The MMC also integrates the first-stage SQUID preamplifier on the same chip as the MMC gamma detector to increase its signal-to-noise ratio. In addition, the MMC uses a passive Ta-Nb heat switch to replace one of the common long-term failure points in earlier detectors. This report discusses the fabrication process we have developed to implement the proposed improvements.
Fabrication of Gamma Detectors Based on Magnetic Ag:Er Microcalorimeters
Energy Technology Data Exchange (ETDEWEB)
Friedrich, Stephan [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Boyd, Stephen [Univ. of New Mexico, Albuquerque, NM (United States); Cantor, Robin [STAR Cryoelectronics, Santa Fe, NM (United States)
2016-05-06
This report discusses the photolithographic fabrication of ultra-high resolution gamma-ray detectors based on magnetic microcalorimeters (MMCs). The MMC uses a novel Er-doped silver sensor (Ag:Er) that is expected to have higher sensitivity than the Er-doped gold (Au:Er) sensors currently in use. The MMC also integrates the first-stage SQUID preamplifier on the same chip as the MMC gamma detector to increase its signal-to-noise ratio. In addition, the MMC uses a passive Ta-Nb heat switch to replace one of the common long-term failure points in earlier detectors. This report discusses the fabrication process we have developed to implement the proposed improvements.
Fabrication of Gamma Detectors Based on Magnetic Ag:Er Microcalorimeters
International Nuclear Information System (INIS)
Friedrich, Stephan; Boyd, Stephen; Cantor, Robin
2016-01-01
This report discusses the photolithographic fabrication of ultra-high resolution gamma-ray detectors based on magnetic microcalorimeters (MMCs). The MMC uses a novel Er-doped silver sensor (Ag:Er) that is expected to have higher sensitivity than the Er-doped gold (Au:Er) sensors currently in use. The MMC also integrates the first-stage SQUID preamplifier on the same chip as the MMC gamma detector to increase its signal-to-noise ratio. In addition, the MMC uses a passive Ta-Nb heat switch to replace one of the common long-term failure points in earlier detectors. This report discusses the fabrication process we have developed to implement the proposed improvements.
Fabrication of Gamma Detectors Based on Magnetic Ag:Er Microcalorimeters
International Nuclear Information System (INIS)
Friedrich, Stephan; Boyd, Stephen; Cantor, Robin
2015-01-01
This report discusses the photolithographic fabrication of ultra-high resolution gamma-ray detectors based on magnetic microcalorimeters (MMCs). The MMC uses a novel Er-doped silver sensor (Ag:Er) that is expected to have higher sensitivity than the Er-doped gold (Au:Er) sensors currently in use. The MMC also integrates the first-stage SQUID preamplifier on the same chip as the MMC gamma detector to increase its signal-to-noise ratio. In addition, the MMC uses a passive Ta-Nb heat switch to replace one of the common long-term failure points in earlier detectors. This report discusses the fabrication process we have developed to implement the proposed improvements.
ER Consolidated Qtrly Rpt_April thru June 2015_October 2015
Energy Technology Data Exchange (ETDEWEB)
Cochran, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
2015-10-01
This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit, and the Compliance Order on Consent. The 13 sites in the Corrective Action process are listed in Table I-1. Because the status of any Long-Term Stewardship (LTS) activity is detailed in other reports, Section I.3.0 (titled Long-Term Stewardship Work Completed) will not be presented in future ER Quarterly Reports. Section I.3.0 of this ER Quarterly Report identifies the other reports that detail LTS activities.
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Garcia-Closas, Montserrat; Couch, Fergus J; Lindstrom, Sara; Michailidou, Kyriaki; Schmidt, Marjanka K; Brook, Mark N; Orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather S; Le Marchand, Loic; Buring, Julie E; Eccles, Diana; Miron, Penelope; Fasching, Peter A; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K; Nevanlinna, Heli; Giles, Graham G; Cox, Angela; Hopper, John L; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J; Schoof, Nils; Bojesen, Stig E; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L; Guénel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S; Lubinski, Jan; Kristensen, Vessela; Swerdlow, Anthony; Anton-Culver, Hoda; Dörk, Thilo; Muir, Kenneth; Matsuo, Keitaro; Wu, Anna H; Radice, Paolo; Teo, Soo Hwang; Shu, Xiao-Ou; Blot, William; Kang, Daehee; Hartman, Mikael; Sangrajrang, Suleeporn; Shen, Chen-Yang; Southey, Melissa C; Park, Daniel J; Hammet, Fleur; Stone, Jennifer; Veer, Laura J Van't; Rutgers, Emiel J; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Peto, Julian; Schrauder, Michael G; Ekici, Arif B; Beckmann, Matthias W; Dos Santos Silva, Isabel; Johnson, Nichola; Warren, Helen; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Milne, Roger L; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Lichtner, Peter; Lochmann, Magdalena; Justenhoven, Christina; Ko, Yon-Dschun; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Greco, Dario; Heikkinen, Tuomas; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Antonenkova, Natalia N; Margolin, Sara; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Balleine, Rosemary; Tseng, Chiu-Chen; Berg, David Van Den; Stram, Daniel O; Neven, Patrick; Dieudonné, Anne-Sophie; Leunen, Karin; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Peterlongo, Paolo; Peissel, Bernard; Bernard, Loris; Olson, Janet E; Wang, Xianshu; Stevens, Kristen; Severi, Gianluca; Baglietto, Laura; McLean, Catriona; Coetzee, Gerhard A; Feng, Ye; Henderson, Brian E; Schumacher, Fredrick; Bogdanova, Natalia V; Labrèche, France; Dumont, Martine; Yip, Cheng Har; Taib, Nur Aishah Mohd; Cheng, Ching-Yu; Shrubsole, Martha; Long, Jirong; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Tollenaar, Robertus A E M; Seynaeve, Caroline M; Kriege, Mieke; Hooning, Maartje J; van den Ouweland, Ans M W; van Deurzen, Carolien H M; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Balasubramanian, Sabapathy P; Cross, Simon S; Reed, Malcolm W R; Signorello, Lisa; Cai, Qiuyin; Shah, Mitul; Miao, Hui; Chan, Ching Wan; Chia, Kee Seng; Jakubowska, Anna; Jaworska, Katarzyna; Durda, Katarzyna; Hsiung, Chia-Ni; Wu, Pei-Ei; Yu, Jyh-Cherng; Ashworth, Alan; Jones, Michael; Tessier, Daniel C; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Vincent, Daniel; Bacot, Francois; Ambrosone, Christine B; Bandera, Elisa V; John, Esther M; Chen, Gary K; Hu, Jennifer J; Rodriguez-Gil, Jorge L; Bernstein, Leslie; Press, Michael F; Ziegler, Regina G; Millikan, Robert M; Deming-Halverson, Sandra L; Nyante, Sarah; Ingles, Sue A; Waisfisz, Quinten; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Gibson, Lorna; Müller-Myhsok, Bertram; Schmutzler, Rita K; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Turnbull, Clare; Rahman, Nazneen; Meijers-Heijboer, Hanne; Uitterlinden, Andre G; Rivadeneira, Fernando; Olswold, Curtis; Slager, Susan; Pilarski, Robert; Ademuyiwa, Foluso; Konstantopoulou, Irene; Martin, Nicholas G; Montgomery, Grant W; Slamon, Dennis J; Rauh, Claudia; Lux, Michael P; Jud, Sebastian M; Bruning, Thomas; Weaver, Joellen; Sharma, Priyanka; Pathak, Harsh; Tapper, Will; Gerty, Sue; Durcan, Lorraine; Trichopoulos, Dimitrios; Tumino, Rosario; Peeters, Petra H; Kaaks, Rudolf; Campa, Daniele; Canzian, Federico; Weiderpass, Elisabete; Johansson, Mattias; Khaw, Kay-Tee; Travis, Ruth; Clavel-Chapelon, Françoise; Kolonel, Laurence N; Chen, Constance; Beck, Andy; Hankinson, Susan E; Berg, Christine D; Hoover, Robert N; Lissowska, Jolanta; Figueroa, Jonine D; Chasman, Daniel I; Gaudet, Mia M; Diver, W Ryan; Willett, Walter C; Hunter, David J; Simard, Jacques; Benitez, Javier; Dunning, Alison M; Sherman, Mark E; Chenevix-Trench, Georgia; Chanock, Stephen J; Hall, Per; Pharoah, Paul D P; Vachon, Celine; Easton, Douglas F; Haiman, Christopher A; Kraft, Peter
2013-04-01
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
Hvem er mest fornøyd med samlivet? : samlivskvalitet blant samboere og gifte
Wiik, Kenneth Aarskaug; Noack, Turid
2011-01-01
Artiklene i Samfunnsspeilet er tilgjengelige fra SSBs nettsider: http://www.ssb.no/ssp/ Norge og Sverige er land der samboerskap har en lang historie, og der denne samlivsformen er mest utbredt. I dag er et av fire samliv her til lands samboerskap. Men også her er det forskjeller mellom samboere og gifte. Hvis vi sammenlikner samlivskvaliteten blant samboere og gifte, finner vi at unge samboere i alderen 25 til 35 år er minst fornøyd med samlivet sitt. Samboere med planer om å gifte seg me...
Er3+-Al2O3 nanoparticles doping of borosilicate glass
International Nuclear Information System (INIS)
Massera, Jonathan; Petit, Laeticia; Hupa, Leena; Hupa, Mikko; Koponen, Joona; Glorieux, Benoit
2015-01-01
Novel borosilicate glasses were developed by adding in the glass batch Er 3+ -Al 2 O 3 nanoparticles synthetized by using a soft chemical method. A similar nanoparticle doping with modified chemical vapour deposition (MCVD) process was developed to increase the efficiency of the amplifying silica fibre in comparison to using MCVD and solution doping. It was shown that with the melt quench technique, a Er 3+ -Al 2 O 3 nanoparticle doping neither leads to an increase in the Er 3+ luminescence properties nor allows one to control the rare-earth chemical environment in a borosilicate glass. The site of Er 3+ in the Er 3+ -Al 2 O 3 nanoparticle containing glass seems to be similar as in glasses with the same composition prepared using standard raw materials. We suspect the Er 3+ ions to diffuse from the nanoparticles into the glass matrix. There was no clear evidence of the presence of Al 2 O 3 nanoparticles in the glasses after melting. (author)
Indian Academy of Sciences (India)
" to. Andrew Z Fire - Stanford University School of Medicine Stanford, CA, USA. Craig C Mello - University of Massachusetts Medical School Worcester, MA, USA. -96----------------------------~~--------R-ES-O-N-A-N-C-E--1 -N-ov-e-m-b-er--2-oo-6.
Er der forskel på grinder og grise?
DEFF Research Database (Denmark)
Heðinsdóttir, Katla; Gjerris, Mickey
2015-01-01
Når det gælder grindedrab, burde man måske spørge, om en tradition, som involverer smerte, angst og andre negative følelser for dyr, er værd at holde fast i, og om det ikke er muligt at fastholde en færøsk identitet uden grindefangst....
Hvilke planter er hjemmehørende i Danmark?
DEFF Research Database (Denmark)
Erik, Buchwald,; Wind, Peter; Bruun, Hans Henrik
2013-01-01
Der har i de senere år været debat om, hvorvidt konkrete plantearter - fx Ær (Acer pseudoplatanus) og Gyvel (Cytisus scoparius) - er hjemmehørende arter i Danmark eller indførte fremmede (Buchwald 2008, 20110: Friis 2010: Møller 2011; Bruun2011). En medvirkende årsag til diskussionerne er, at derr...
Din tandbørste og pejsen er online
DEFF Research Database (Denmark)
Damsgaard, Jan
2016-01-01
Det er snart definitivt slut med de store mysterier om flys forsvinden og massive eftersøgninger efter overlevende. Danske Naviair er i disse år med til at sende 66 satellitter i kredsløb om Jorden. Så kan alle kommercielle fly følges, uanset hvor på jordkloden de befinder sig....
Phase relationships in the Er-Mn-Ti ternary system at 773 K
International Nuclear Information System (INIS)
Liu Jingqi; Wang Xina; Tang Mengqi; Su Kunpeng; Yang Xiaomao; Li Chunhui; Li Xueqiang
2009-01-01
The Phase relationship in the Er-Mn-Ti ternary system at 773 K has been investigated by X-ray powder diffraction analysis with the aid of differential thermal analysis and optical microanalysis techniques in this work. The existence of eight binary compounds Mn 15 Ti 85, αMnTi, βMnTi, Mn 2 Ti, Mn 5 Ti, ErMn 12, Er 6 Mn 23 and ErMn 2 has been confirmed at 773 K in this system. The maximum solid solubility of Ti in Mn is about 8 at%Ti. The homogeneity range of Mn 2 Ti extends from about 31 at% to 39 at% Ti. The maximum solid solubility of Er in Mn 2 Ti phase is about less than 1 at% Er. No ternary compounds were found in this ternary system at 773K. At 773 K, the isothermal section of phase diagram of Er-Mn-Ti ternary system consists of 11 single-phase regions, 19 two-phase regions and 9 three-phase regions.
DEFF Research Database (Denmark)
Kaiser, Birte
2009-01-01
En artikel i bogen: 6 belysninger af vejledning, brydninger, forståelser & praksis. Artiklen er et sammendrag af en diskursanalyse fra 2008 fra projetrapporten: Ind under huden, www.vejledning.net...
ER Consolidated Qtrly Rpt_April-June 2016_October 2016
Energy Technology Data Exchange (ETDEWEB)
Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
2016-10-01
This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) for the April, May, and June 2016 quarterly reporting period.
Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis.
Schneeberger, Marc; Gómez-Valadés, Alicia G; Altirriba, Jordi; Sebastián, David; Ramírez, Sara; Garcia, Ainhoa; Esteban, Yaiza; Drougard, Anne; Ferrés-Coy, Albert; Bortolozzi, Analía; Garcia-Roves, Pablo M; Jones, John G; Manadas, Bruno; Zorzano, Antonio; Gomis, Ramon; Claret, Marc
2015-07-21
Alterations in ER homeostasis have been implicated in the pathophysiology of obesity and type-2 diabetes (T2D). Acute ER stress induction in the hypothalamus produces glucose metabolism perturbations. However, the neurobiological basis linking hypothalamic ER stress with abnormal glucose metabolism remains unknown. Here, we report that genetic and induced models of hypothalamic ER stress are associated with alterations in systemic glucose homeostasis due to increased gluconeogenesis (GNG) independent of body weight changes. Defective alpha melanocyte-stimulating hormone (α-MSH) production underlies this metabolic phenotype, as pharmacological strategies aimed at rescuing hypothalamic α-MSH content reversed this phenotype at metabolic and molecular level. Collectively, our results posit defective α-MSH processing as a fundamental mediator of enhanced GNG in the context of hypothalamic ER stress and establish α-MSH deficiency in proopiomelanocortin (POMC) neurons as a potential contributor to the pathophysiology of T2D. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
ER stress affects processing of MHC class I-associated peptides
Directory of Open Access Journals (Sweden)
Meloche Sylvain
2009-02-01
Full Text Available Abstract Background Viral infection and neoplastic transformation trigger endoplasmic reticulum (ER stress. Thus, a large proportion of the cells that must be recognized by the immune system are stressed cells. Cells respond to ER stress by launching the unfolded protein response (UPR. The UPR regulates the two key processes that control major histocompatibility complex class I (MHC I-peptide presentation: protein synthesis and degradation. We therefore asked whether and how the UPR impinges on MHC I-peptide presentation. Results We evaluated the impact of the UPR on global MHC I expression and on presentation of the H2Kb-associated SIINFEKL peptide. EL4 cells stably transfected with vectors coding hen egg lysozyme (HEL-SIINFEKL protein variants were stressed with palmitate or exposed to glucose deprivation. UPR decreased surface expression of MHC I but did not affect MHC I mRNA level nor the total amount of intracellular MHC I proteins. Impaired MHC I-peptide presentation was due mainly to reduced supply of peptides owing to an inhibition of overall protein synthesis. Consequently, generation of H2Kb-SIINFEKL complexes was curtailed during ER stress, illustrating how generation of MHC I peptide ligands is tightly coupled to ongoing protein synthesis. Notably, the UPR-induced decline of MHC I-peptide presentation was more severe when the protein source of peptides was localized in the cytosol than in the ER. This difference was not due to changes in the translation rates of the precursor proteins but to increased stability of the cytosolic protein during ER stress. Conclusion Our results demonstrate that ER stress impairs MHC I-peptide presentation, and that it differentially regulates expression of ER- vs. cytosol-derived peptides. Furthermore, this work illustrates how ER stress, a typical feature of infected and malignant cells, can impinge on cues for adaptive immune recognition.
Facets of operational performance in an emergency room (ER)
van der Vaart, Taco; Vastag, Gyula; Wijngaard, Jacob
This paper, using detailed time measurements of patients complemented by interviews with hospital management and staff, examines three facets of an emergency room's (ER) operational performance: (1) effectiveness of the triage system in rationing patient treatment; (2) factors influencing ER's
Directory of Open Access Journals (Sweden)
Hande Gülbağcı Dede
2016-04-01
Full Text Available The aim of this study is to compare professional identity of pre-service mathematics teachers in pedagogical formation certificate program and undergraduate teacher education program in the context of pre-service teachers’ stories of becoming a mathematics teacher. A total of 113 pre-service elementary mathematics teachers participated in the study. 58 of them were enrolled in undergraduate teacher education program and 55 of them were enrolled in pedagogical formation certificate program. Demographic questionnaire and reflective essays on pre-service teachers’ stories of becoming a teacher were used as data collection tools. Demographic questionnaires were analyzed descriptively and pre-service teachers’ writings were analyzed using content analysis. Data analysis indicated that two groups had similarities in reasons for why they chose teaching as a profession and mathematics as a subject for teaching. Their earlier teaching experiences in high school and their role model teachers were the most observed reasons for why they chose teaching as a profession. The main difference between the two groups was their determination for aiming to be a teacher. Participants in the undergraduate teacher education program decided to be a teacher in high school while some of the participants in the other group decided to have a teaching certificate just in case they might need it in the future. Interest and success in mathematics were the most important factors for choosing mathematics as a subject for teaching in both groups. [Bu çalışmanın amacı pedagojik formasyon eğitimi sertifika programına katılan öğretmen adayları ile ortaöğretim matematik öğretmenliği lisans programına devam eden öğretmen adaylarının mesleki kimliklerinin öğretmen olma hikayeleri bağlamında karşılaştırılmasıdır. Çalışmaya 55’i pedagojik formasyon eğitimi sertifika programına, 58’i ortaöğretim matematik öğretmenliği lisans program
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Garcia-Closas, Montserrat; Couch, Fergus J.; Lindstrom, Sara; Michailidou, Kyriaki; Schmidt, Marjanka K.; Brook, Mark N.; Orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather S.; Le Marchand, Loic; Buring, Julie E.; Eccles, Diana; Miron, Penelope; Fasching, Peter A.; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K.; Nevanlinna, Heli; Giles, Graham G.; Cox, Angela; Hopper, John L.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J.; Schoof, Nils; Bojesen, Stig E.; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L.; Guénel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J.; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S.; Lubinski, Jan; Kristensen, Vessela; Swerdlow, Anthony; Anton-Culver, Hoda; Dörk, Thilo; Muir, Kenneth; Matsuo, Keitaro; Wu, Anna H.; Radice, Paolo; teo, Soo Hwang; Shu, Xiao-Ou; Blot, William; Kang, Daehee; Hartman, Mikael; Sangrajrang, Suleeporn; Shen, Chen-Yang; Southey, Melissa C.; Park, Daniel J.; Hammet, Fleur; Stone, Jennifer; Veer, Laura J. Van't; Rutgers, Emiel J.; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Peto, Julian; Schrauder, Michael G.; Ekici, Arif B.; Beckmann, Matthias W.; dos Santos Silva, Isabel; Johnson, Nichola; Warren, Helen; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Milne, Roger L.; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Lichtner, Peter; Lochmann, Magdalena; Justenhoven, Christina; Ko, Yon-Dschun; Muranen, Taru A.; Aittomäki, Kristiina; Blomqvist, Carl; Greco, Dario; Heikkinen, Tuomas; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Antonenkova, Natalia N.; Margolin, Sara; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Balleine, Rosemary; Tseng, Chiu-Chen; Berg, David Van Den; Stram, Daniel O.; Neven, Patrick; Dieudonné, Anne-Sophie; Leunen, Karin; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Peterlongo, Paolo; Peissel, Bernard; Bernard, Loris; Olson, Janet E.; Wang, Xianshu; Stevens, Kristen; Severi, Gianluca; Baglietto, Laura; McLean, Catriona; Coetzee, Gerhard A.; Feng, Ye; Henderson, Brian E.; Schumacher, Fredrick; Bogdanova, Natalia V.; Labrèche, France; Dumont, Martine; Yip, Cheng Har; Taib, Nur Aishah Mohd; Cheng, Ching-Yu; Shrubsole, Martha; Long, Jirong; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Tollenaar, Robertus A. E. M.; Seynaeve, Caroline M.; Kriege, Mieke; Hooning, Maartje J.; van den Ouweland, Ans M. W.; van Deurzen, Carolien H. M.; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Balasubramanian, Sabapathy P.; Cross, Simon S.; Reed, Malcolm W. R.; Signorello, Lisa; Cai, Qiuyin; Shah, Mitul; Miao, Hui; Chan, Ching Wan; Chia, Kee Seng; Jakubowska, Anna; Jaworska, Katarzyna; Durda, Katarzyna; Hsiung, Chia-Ni; Wu, Pei-Ei; Yu, Jyh-Cherng; Ashworth, Alan; Jones, Michael; Tessier, Daniel C.; González-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Vincent, Daniel; Bacot, Francois; Ambrosone, Christine B.; Bandera, Elisa V.; John, Esther M.; Chen, Gary K.; Hu, Jennifer J.; Rodriguez-Gil, Jorge L.; Bernstein, Leslie; Press, Michael F.; Ziegler, Regina G.; Millikan, Robert M.; Deming-Halverson, Sandra L.; Nyante, Sarah; Ingles, Sue A.; Waisfisz, Quinten; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Gibson, Lorna; Müller-Myhsok, Bertram; Schmutzler, Rita K.; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Turnbull, Clare; Rahman, Nazneen; Meijers-Heijboer, Hanne; Uitterlinden, Andre G.; Rivadeneira, Fernando; Olswold, Curtis; Slager, Susan; Pilarski, Robert; Ademuyiwa, Foluso; Konstantopoulou, Irene; Martin, Nicholas G.; Montgomery, Grant W.; Slamon, Dennis J.; Rauh, Claudia; Lux, Michael P.; Jud, Sebastian M.; Bruning, Thomas; Weaver, Joellen; Sharma, Priyanka; Pathak, Harsh; Tapper, Will; Gerty, Sue; Durcan, Lorraine; Trichopoulos, Dimitrios; Tumino, Rosario; Peeters, Petra H.; Kaaks, Rudolf; Campa, Daniele; Canzian, Federico; Weiderpass, Elisabete; Johansson, Mattias; Khaw, Kay-Tee; Travis, Ruth; Clavel-Chapelon, Françoise; Kolonel, Laurence N.; Chen, Constance; Beck, Andy; Hankinson, Susan E.; Berg, Christine D.; Hoover, Robert N.; Lissowska, Jolanta; Figueroa, Jonine D.; Chasman, Daniel I.; Gaudet, Mia M.; Diver, W. Ryan; Willett, Walter C.; Hunter, David J.; Simard, Jacques; Benitez, Javier; Dunning, Alison M.; Sherman, Mark E.; Chenevix-Trench, Georgia; Chanock, Stephen J.; Hall, Per; Pharoah, Paul D. P.; Vachon, Celine; Easton, Douglas F.; Haiman, Christopher A.; Kraft, Peter
2013-01-01
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including
Derfor er zoner en god idé for naturen og pengepungen
DEFF Research Database (Denmark)
Hansen, Anne Merrild; Dahl, Hjalmar
2014-01-01
I rapporten ”Til Gavn for Grønland” var en zoneinddeling af landet et tema. I den offentlige debat er zoneringstanken blevet opfattet, som en (urealistisk) friholdelse af arealer for industri-aktivitet. Men ideen bag zonerne er også til fordel for erhvervslivet og økonomien. Det er en prioriterin...
Genome-wide association studies identify four ER negative–specific breast cancer risk loci
Garcia-Closas, Montserrat; Couch, Fergus J; Lindstrom, Sara; Michailidou, Kyriaki; Schmidt, Marjanka K; Brook, Mark N; orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather s; Le Marchand, Loic; Buring, Julie E; Eccles, Diana; Miron, Penelope; Fasching, Peter A; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K; Nevanlinna, Heli; Giles, Graham G; Cox, Angela; Hopper, John L; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J; Schoof, Nils; Bojesen, Stig E; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L; Guénel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S; Lubinski, Jan; Kristensen, Vessela; Swerdlow, Anthony; Anton-Culver, Hoda; Dörk, Thilo; Muir, Kenneth; Matsuo, Keitaro; Wu, Anna H; Radice, Paolo; Teo, Soo Hwang; Shu, Xiao-Ou; Blot, William; Kang, Daehee; Hartman, Mikael; Sangrajrang, Suleeporn; Shen, Chen-Yang; Southey, Melissa C; Park, Daniel J; Hammet, Fleur; Stone, Jennifer; Veer, Laura J Van’t; Rutgers, Emiel J; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Peto, Julian; Schrauder, Michael G; Ekici, Arif B; Beckmann, Matthias W; Silva, Isabel dos Santos; Johnson, Nichola; Warren, Helen; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Milne, Roger L; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Lichtner, Peter; Lochmann, Magdalena; Justenhoven, Christina; Ko, Yon-Dschun; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Greco, Dario; Heikkinen, Tuomas; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Antonenkova, Natalia N; Margolin, Sara; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Balleine, Rosemary; Tseng, Chiu-Chen; Van Den Berg, David; Stram, Daniel O; Neven, Patrick; Dieudonné, Anne-Sophie; Leunen, Karin; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Peterlongo, Paolo; Peissel, Bernard; Bernard, Loris; Olson, Janet E; Wang, Xianshu; Stevens, Kristen; Severi, Gianluca; Baglietto, Laura; Mclean, Catriona; Coetzee, Gerhard A; Feng, Ye; Henderson, Brian E; Schumacher, Fredrick; Bogdanova, Natalia V; Labrèche, France; Dumont, Martine; Yip, Cheng Har; Taib, Nur Aishah Mohd; Cheng, Ching-Yu; Shrubsole, Martha; Long, Jirong; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Tollenaar, Robertus A E M; Seynaeve, Caroline M; Kriege, Mieke; Hooning, Maartje J; Van den Ouweland, Ans M W; Van Deurzen, Carolien H M; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Balasubramanian, Sabapathy P; Cross, Simon S; Reed, Malcolm W R; Signorello, Lisa; Cai, Qiuyin; Shah, Mitul; Miao, Hui; Chan, Ching Wan; Chia, Kee Seng; Jakubowska, Anna; Jaworska, Katarzyna; Durda, Katarzyna; Hsiung, Chia-Ni; Wu, Pei-Ei; Yu, Jyh-Cherng; Ashworth, Alan; Jones, Michael; Tessier, Daniel C; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Vincent, Daniel; Bacot, Francois; Ambrosone, Christine B; Bandera, Elisa V; John, Esther M; Chen, Gary K; Hu, Jennifer J; Rodriguez-gil, Jorge L; Bernstein, Leslie; Press, Michael F; Ziegler, Regina G; Millikan, Robert M; Deming-Halverson, Sandra L; Nyante, Sarah; Ingles, Sue A; Waisfisz, Quinten; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Gibson, Lorna; Müller-Myhsok, Bertram; Schmutzler, Rita K; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Turnbull, Clare; Rahman, Nazneen; Meijers-Heijboer, Hanne; Uitterlinden, Andre G; Rivadeneira, Fernando; Olswold, Curtis; Slager, Susan; Pilarski, Robert; Ademuyiwa, Foluso; Konstantopoulou, Irene; Martin, Nicholas G; Montgomery, Grant W; Slamon, Dennis J; Rauh, Claudia; Lux, Michael P; Jud, Sebastian M; Bruning, Thomas; Weaver, Joellen; Sharma, Priyanka; Pathak, Harsh; Tapper, Will; Gerty, Sue; Durcan, Lorraine; Trichopoulos, Dimitrios; Tumino, Rosario; Peeters, Petra H; Kaaks, Rudolf; Campa, Daniele; Canzian, Federico; Weiderpass, Elisabete; Johansson, Mattias; Khaw, Kay-Tee; Travis, Ruth; Clavel-Chapelon, Françoise; Kolonel, Laurence N; Chen, Constance; Beck, Andy; Hankinson, Susan E; Berg, Christine D; Hoover, Robert N; Lissowska, Jolanta; Figueroa, Jonine D; Chasman, Daniel I; Gaudet, Mia M; Diver, W Ryan; Willett, Walter C; Hunter, David J; Simard, Jacques; Benitez, Javier; Dunning, Alison M; Sherman, Mark E; Chenevix-Trench, Georgia; Chanock, Stephen J; Hall, Per; Pharoah, Paul D P; Vachon, Celine; Easton, Douglas F; Haiman, Christopher A; Kraft, Peter
2013-01-01
Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry1. The etiology2 and clinical behavior3 of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition4. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10−12 and LGR6, P = 1.4 × 10−8), 2p24.1 (P = 4.6 × 10−8) and 16q12.2 (FTO, P = 4.0 × 10−8), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers. PMID:23535733
DEBONDING OF CERAMIC BRACKETS BY ER:YAG LASER
Directory of Open Access Journals (Sweden)
Fidan ALAKUŞ-SABUNCUOĞLU
2016-04-01
Full Text Available Purpose: The objective of the present study is to evaluate the effects of Er:YAG laser debonding of ceramic brackets on the bond strength and the amount of adhesive resin remnant. Materials and Methods: Twenty human mandibular incisors were randomly divided into two groups of 10 and polycrystalline ceramic brackets (Transcend series 6000, 3M Unitek, Monrovia, CA, USA were bonded on enamel surfaces. Group 1 was the control group in which no laser application was performed prior to the shear bond strength (SBS testing. In Group 2, Er:YAG was applied in 3W power for 6 seconds using the scanning method. The brackets were tested for SBS with an Instron universal testing machine and results were expressed in megapascals (MPa. The amount of adhesive remnant was evaluated with Adhesive Remnant Index (ARI. One-way analysis of variance and Tukey’s post-hoc tests were used for statistical analysis. Results: Mean ± standard deviation of SBS values in the control group was 13.42 ±1.23 MPa and 8.47 ±0.71 MPa in the Er:YAG group and this difference was statistically significant (p<0.05. The evaluation of ARI scores demonstrated more adhesive was left on the enamel surface with Er:YAG group. Conclusion: 3W power Er:YAG laser application with the scanning method to polycrystalline ceramic brackets demonstrated lower bond strengths and higher ARI scores during the debonding procedure.
Regulation of ER-Golgi Transport Dynamics by GTPases in Budding Yeast
Directory of Open Access Journals (Sweden)
Yasuyuki Suda
2018-01-01
Full Text Available A large number of proteins are synthesized de novo in the endoplasmic reticulum (ER. They are transported through the Golgi apparatus and then delivered to their proper destinations. The ER and the Golgi play a central role in protein processing and sorting and show dynamic features in their forms. Ras super family small GTPases mediate the protein transport through and between these organelles. The ER-localized GTPase, Sar1, facilitates the formation of COPII transport carriers at the ER exit sites (ERES on the ER for the transport of cargo proteins from the ER to the Golgi. The Golgi-localized GTPase, Arf1, controls intra-Golgi, and Golgi-to-ER transport of cargo proteins by the formation of COPI carriers. Rab GTPases localized at the Golgi, which are responsible for fusion of membranes, are thought to establish the identities of compartments. Recent evidence suggests that these small GTPases regulate not only discrete sites for generation/fusion of transport carriers, but also membrane dynamics of the organelles where they locate to ensure the integrity of transport. Here we summarize the current understandings about the membrane traffic between these organelles and highlight the cutting-edge advances from super-resolution live imaging of budding yeast, Saccharomyces cerevisiae.
Hvad er smag, og hvordan underviser man i og med smag?
DEFF Research Database (Denmark)
Qvortrup, Lars; Wistoft, Karen
2017-01-01
Hvad er smag, og hvordan underviser man i smag som undervisningens genstand eller med smag som et virkemiddel i undervisningen? Det er denne artikels to hovedspørgsmål. Formålet er at præsentere det, der kaldes en smagsdidaktisk refleksionsteori, dvs. en teori der reflekterer over, hvordan man un...
Provokerende kærester, armhuler og en lille smule AIDS
DEFF Research Database (Denmark)
Cortsen, Rikke Platz
2010-01-01
I Sverige gør de noget, som man ikke gør i Danmark. Kvinderne. De tegner tegneserier. I massevis. Og de udgiver dem glad og gerne med en stilmæssig variation, der kun kan imponere. Hver især har sin helt særegne og personlige stil, og som regel ligner det ikke noget, man har set før. Det tætteste...
Compressive characteristics of closed-cell aluminum foams with different percentages of Er element
Directory of Open Access Journals (Sweden)
Wei-min Zhao
2016-01-01
Full Text Available In the present study, closed-cell aluminum foams with different percentages of erbium (Er element were successfully prepared. The distribution and existence form of erbium (Er element and its effect on the compressive properties of the foams were investigated. Results show that Er uniformly distributes in the cell walls in the forms of Al3Er intermetallic compound and Al-Er solid solutions. Compared with commercially pure aluminum foam, Er-containing foams possess higher micro-hardness, compressive strength and energy absorption capacity due to solid solution strengthening and second phase strengthening effects. Additionally, the amount of Er element should be controlled in the range of 0.10wt.%-0.50wt.% in order to obtain a good combination of compressive strength and energy absorption properties.
Observation of large magnetocaloric effect in equiatomic binary compound ErZn
Directory of Open Access Journals (Sweden)
Lingwei Li
2017-05-01
Full Text Available The magnetism, magnetocaloric effect and universal behaviour in rare earth Zinc binary compound of ErZn have been studied. The ErZn compound undergoes a second order paramagnetic (PM to ferromagnetic (FM transition at Curie temperature of TC ∼ 20 K. The ErZn compound exhibits a large reversible magnetocaloric effect (MCE around its own TC. The rescaled magnetic entropy change curves overlap with each other under various magnetic field changes, further confirming the ErZn with the second order phase transition. For the magnetic field change of 0-7 T, the maximum values of the magnetic entropy change (−ΔSMmax, relative cooling power (RCP and refrigerant capacity (RC for ErZn are 23.3 J/kg K, 581 J/kg and 437 J/kg, respectively.
DEFF Research Database (Denmark)
2017-01-01
Riget indtager en nøglestilling, når overgangen mellem faser i Triers produktion skal karakteriseres. Riget danner bro mellem den billedfascination og de radikale stileksperimenter, der præger Triers tidlige produktion, og den genre- og plotbevidsthed, der er typisk for film som Breaking the Waves...
DEFF Research Database (Denmark)
Skriver Jensen, Anders
2009-01-01
Forfatteren argumenterer for at "early literacy" kan oversættes til "tidligt sprog"; særligt når der er tale om en helhedsorienteret tilgang med vægt på sprog som et alsidigt medie for kommunikation- og betydningsskabelse. Med inspiration fra Jerome Bruners kulturpsykologi diskuteres mulige...
Monitoring sea level and sea surface temperature trends from ERS satellites
DEFF Research Database (Denmark)
Andersen, Ole Baltazar; Knudsen, Per; Beckley, B.
2002-01-01
Data from the two ESA satellites ERS-1 and ERS-2 are used in global and regional analysis of sea level and sea surface temperature trends over the last, 7.8 years. T he ERS satellites and in the future the ENVISAT satellite provide unique opportunity for monitoring both changes in sea level and sea...
TaER Expression Is Associated with Transpiration Efficiency Traits and Yield in Bread Wheat.
Zheng, Jiacheng; Yang, Zhiyuan; Madgwick, Pippa J; Carmo-Silva, Elizabete; Parry, Martin A J; Hu, Yin-Gang
2015-01-01
ERECTA encodes a receptor-like kinase and is proposed as a candidate for determining transpiration efficiency of plants. Two genes homologous to ERECTA in Arabidopsis were identified on chromosomes 6 (TaER2) and 7 (TaER1) of bread wheat (Triticum aestivum L.), with copies of each gene on the A, B and D genomes of wheat. Similar expression patterns were observed for TaER1 and TaER2 with relatively higher expression of TaER1 in flag leaves of wheat at heading (Z55) and grain-filling (Z73) stages. Significant variations were found in the expression levels of both TaER1 and TaER2 in the flag leaves at both growth stages among 48 diverse bread wheat varieties. Based on the expression of TaER1 and TaER2, the 48 wheat varieties could be classified into three groups having high (5 varieties), medium (27 varieties) and low (16 varieties) levels of TaER expression. Significant differences were also observed between the three groups varying for TaER expression for several transpiration efficiency (TE)- related traits, including stomatal density (SD), transpiration rate, photosynthetic rate (A), instant water use efficiency (WUEi) and carbon isotope discrimination (CID), and yield traits of biomass production plant-1 (BYPP) and grain yield plant-1 (GYPP). Correlation analysis revealed that the expression of TaER1 and TaER2 at the two growth stages was significantly and negatively associated with SD (Ptranspiration rate (Ptranspiration efficiency -related traits and yield in bread wheat, implying a function for TaER in regulating leaf development of bread wheat and contributing to expression of these traits. Moreover, the results indicate that TaER could be exploitable for manipulating important agronomical traits in wheat improvement.
DEFF Research Database (Denmark)
Bonde, Lars Ole
2015-01-01
”Det man hører, er man selv” er Danmarks Radios P3s yderst velkendte slogan. Det dukkede op i begyndelsen af (20)00erne som opfindsom og populær afspejling af en moderne forståelse af den rolle musik og medieforbrug spiller for den voksne dansker. Denne artikel handler ikke om P3 som musikkanal...
DEFF Research Database (Denmark)
Rosenbaum, Philip
2017-01-01
I en tid, hvor ”det postfaktuelle samfund” er det mest populære udtryk øst for Valby bakke, er det vigtigt for de profaktuelle fanebærere at forstå, at fakta og evidens ikke i sig selv ændrer på folks opfattelse og holdninger. For at evidensbaserede argumenter skal få en vigtig position i samfund...
20 CFR 222.24 - Relationship as remarried widow(er).
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship as remarried widow(er). 222.24 Section 222.24 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Divorced Spouse, Surviving Divorced Spouse, or Remarried Widow(er...
Toprakcı, Erdal
2017-01-01
Editörden 2017 yılının ikinci sayısıyla yeniden sizinleyiz. Kaliteye verdiğimiz önem sayesinde, çok kısa sürede adından söz ettiren bir dergiye dönüştük. Kuşkusuz bu süreçte en önemli etken yazarlarımız ve hakemlerimizin titizliğidir.Dergimizin bu sayısında şunlar var: Birinci olarak, YBO’da öğrenim gören öğrencilerin matematiğe yönelik genel tutumların olumlu olduğu, tutum puanlarının sınıf düzeyi, matematik başarısı, matematik öğretmeni sevme düzeyi, matematik önem algısı ve öz-yeterlik baş...
Internationale medier: Når sproget er den eneste forskel
DEFF Research Database (Denmark)
Andersen, Rune Saugmann
2009-01-01
forhandlingerne som formålet med dem. Det gør der ikke mere. Efter tusindvis af historier i dusinvis af førende aviser verden over ser det ud til at der kun er én historie tilbage: Det neo-liberale udviklingseventyr. For i perioden 2001-2006 – hvor jeg har analyseret pressedækningen i USA, Spanien, England......, Indien og Argentina – er der sket en bemærkelsesværdig ensretning af presseomtalen af forhandlingerne – i øvrigt sideløbende med at forhandlingerne er blevet stadig mere fastlåste. ...
Long afterglow property of Er"3"+ doped Ca_2SnO_4 phosphor
International Nuclear Information System (INIS)
Zhang, Dongyun; Shi, Mingming; Sun, Yiwen; Guo, Yunyun; Chang, Chengkang
2016-01-01
A novel green emitting long afterglow phosphor, Er"3"+ -doped Ca_2SnO_4 (Ca_2SnO_4:Er"3"+), was prepared successfully via a traditional high temperature solid–state reaction method. Its properties have been characterized and analyzed by utilizing x-ray diffraction (XRD), photoluminescence spectroscope (PLS), afterglow decay curve (ADC) and thermal luminescence spectroscope (TLS). Three main emission peaks of PLS locate at 524, 550 and 668 nm, corresponding to CIE chromaticity coordinates of x = 0.326, y = 0.6592. An optimal doping concentration of Er"3"+ of 2% was determined. The Ca_2SnO_4:Er"3"+ phosphors showed a typical triple-exponential afterglow decay behavior when the UV source was switched off. Thermal simulated luminescence study indicated that the persistent afterglow of Ca_2SnO_4:2 mol% Er"3"+ phosphors was generated by the suitable electron or hole traps which were resulted from the doping the Ca_2SnO_4 host with rare-earth ions (Er"3"+). - Highlights: • A novel green emitting long afterglow phosphor, Ca_2SnO_4:Er"3"+, was prepared. • An optimal doping concentration of Er"3"+ of 2% was determined. • After the UV source was turned off, the Ca_2SnO_4:Er"3"+ showed a typical triple-exponential afterglow decay behavior. • CIE chromaticity coordinates results confirmed a green light emitting of the Ca_2SnO_4:Er"3"+. • The persistent afterglow of the Ca_2SnO_4:Er"3"+ was attributed to suitable electron or hole traps.
Continuously tunable cw lasing near 2.75 μm in diode-pumped Er3+ : SrF2 and Er3+ : CaF2 crystals
International Nuclear Information System (INIS)
Basiev, Tasoltan T; Orlovskii, Yu V; Polyachenkova, M V; Fedorov, Pavel P; Kuznetsov, S V; Konyushkin, V A; Osiko, Vyacheslav V; Alimov, Olimkhon K; Dergachev, Alexey Yu
2006-01-01
CW lasing is obtained in Er 3+ (5%) : CaF 2 and Er 3+ (5%) : SrF 2 crystals near 2.75 μm with 0.4 and 2 W of output powers, respectively, upon transverse diode laser pumping into the upper 4 I 11/2 laser level of erbium ions at 980 nm. Continuous tuning of the laser wavelength between 2720 and 2760 nm is realised in the Er 3+ : SrF 2 crystal. (special issue devoted to the 90th anniversary of a.m. prokhorov)
Kim, Jinhwan; Choi, Tae Gyu; Ding, Yan; Kim, Yeonghwan; Ha, Kwon Soo; Lee, Kyung Ho; Kang, Insug; Ha, Joohun; Kaufman, Randal J; Lee, Jinhwa; Choe, Wonchae; Kim, Sung Soo
2008-11-01
Prolonged accumulation of misfolded proteins in the endoplasmic reticulum (ER) results in ER stress-mediated apoptosis. Cyclophilins are protein chaperones that accelerate the rate of protein folding through their peptidyl-prolyl cis-trans isomerase (PPIase) activity. In this study, we demonstrated that ER stress activates the expression of the ER-localized cyclophilin B (CypB) gene through a novel ER stress response element. Overexpression of wild-type CypB attenuated ER stress-induced cell death, whereas overexpression of an isomerase activity-defective mutant, CypB/R62A, not only increased Ca(2+) leakage from the ER and ROS generation, but also decreased mitochondrial membrane potential, resulting in cell death following exposure to ER stress-inducing agents. siRNA-mediated inhibition of CypB expression rendered cells more vulnerable to ER stress. Finally, CypB interacted with the ER stress-related chaperones, Bip and Grp94. Taken together, we concluded that CypB performs a crucial function in protecting cells against ER stress via its PPIase activity.
Sund livsstil er mere end fysik
DEFF Research Database (Denmark)
Nybo, Lars; Thing, Lone Friis; Astrup, Arne
2015-01-01
. I virkeligheden hænger tingene sammen, og i et holistisk sundhedsbillede er de psykiske og sociale dimensioner mindst lige så vigtige som de fysiske. Fællesskabet under og efter fodboldtræningen kan for eksempel være en lige så vigtig del af at være aktiv som selve træningen. Og selv om nogle...... begynder på en aktiv livsstil ud fra en ydre motivation om det fysiske aspekt af ’mere sundhed’, så er der meget, som tyder på, at den indre motivation overtager, og at de i stedet bliver drevet af glæden ved den øgede livskvalitet. Nogle mennesker fascineres af at følge en fast træningsplan og have et...... behandling af inaktivitetsrelaterede lidelser bør dog ikke være det vigtigste argument for at oplyse om og opfordre til en sund livsstil. Livskvalitetsaspektet skal være i højsædet, og det er for så vidt en legitim bekymring, at der kommer et overdrevet fokus på samfundsøkonomi og forebyggelse af somatisk...
Excitation mechanisms of Er optical centers in GaN epilayers
International Nuclear Information System (INIS)
George, D. K.; Hawkins, M. D.; McLaren, M.; Vinh, N. Q.; Jiang, H. X.; Lin, J. Y.; Zavada, J. M.
2015-01-01
We report direct evidence of two mechanisms responsible for the excitation of optically active Er 3+ ions in GaN epilayers grown by metal-organic chemical vapor deposition. These mechanisms, resonant excitation via the higher-lying inner 4f shell transitions and band-to-band excitation of the semiconductor host, lead to narrow emission lines from isolated and the defect-related Er optical centers. However, these centers have different photoluminescence spectra, local defect environments, decay dynamics, and excitation cross sections. The photoluminescence at 1.54 μm from the isolated Er optical center which can be excited by either mechanism has the same decay dynamics, but possesses a much higher excitation cross-section under band-to-band excitation. In contrast, the photoluminescence at 1.54 μm from the defect-related Er optical center can only be observed through band-to-band excitation but has the largest excitation cross-section. These results explain the difficulty in achieving gain in Er doped GaN and indicate approaches for realization of optical amplification, and possibly lasing, at room temperature
Tamoxifen-independent recombination in the RIP-CreER mouse.
Directory of Open Access Journals (Sweden)
Yanmei Liu
Full Text Available BACKGROUND: The inducible Cre-lox system is a valuable tool to study gene function in a spatial and time restricted fashion in mouse models. This strategy relies on the limited background activity of the modified Cre recombinase (CreER in the absence of its inducer, the competitive estrogen receptor ligand, tamoxifen. The RIP-CreER mouse (Tg (Ins2-cre/Esr1 1Dam is among the few available β-cell specific CreER mouse lines and thus it has been often used to manipulate gene expression in the insulin-producing cells of the endocrine pancreas. PRINCIPAL FINDINGS: Here, we report the detection of tamoxifen-independent Cre activity as early as 2 months of age in RIP-CreER mice crossed with three distinct reporter strains. SIGNIFICANCE: Evidence of Cre-mediated recombination of floxed alleles even in the absence of tamoxifen administration should warrant cautious use of this mouse for the study of pancreatic β-cells.
GPM Ground Validation Navigation Data ER-2 OLYMPEX V1
National Aeronautics and Space Administration — The GPM Ground Validation NASA ER-2 Navigation Data OLYMPEX dataset supplies navigation data collected by the NASA ER-2 aircraft for flights that occurred during...
Stress sensing in plants by the ER stress sensor/transducer, bZIP28
Directory of Open Access Journals (Sweden)
Renu eSrivastava
2014-02-01
Full Text Available Two classes of ER stress sensors are known in plants, membrane associated bZIP transcription factors and RNA splicing factors. ER stress occurs under adverse environmental conditions and results from the accumulation of misfolded or unfolded proteins in the ER lumen. One of the membrane-associated transcription factors activated by heat and ER stress agents is bZIP28. In its inactive form, bZIP28 is a type II protein with a single pass transmembrane domain, residing in the ER. bZIP28’s N-terminus, containing a transcriptional activation domain, is oriented towards the cytoplasm and its C-terminal tail is inserted into the ER lumen. In response to stress, bZIP28 exits the ER and moves to the Golgi where it is proteolytically processed, liberating its cytosolic component which relocates to the nucleus to upregulate stress-response genes. bZIP28 is thought to sense stress through its interaction with the major ER chaperone, BIP. BiP binds to bZIP28’s lumenal domain under unstressed conditions and retains it in the ER. BIP binds to the intrinsically disordered regions on bZIP28’s lumen-facing tail. A truncated form of bZIP28, without its C-terminal tail is not retained in the ER but migrates constitutively to the nucleus. Upon stress, BiP releases bZIP28 allowing it to exit the ER. One model to account for the release of bZIP28 by BiP is that BiP is competed away from bZIP28 by the accumulation of misfolded proteins in the ER. However, other forces such as changes in energy charge levels, redox conditions or interaction with DNAJ proteins may also promote release of bZIP28 from BiP. Movement of bZIP28 from the ER to the Golgi is assisted by the interaction of elements of the COPII machinery with the cytoplasmic domain of bZIP28. Thus, the mobilization of bZIP28 in response to stress involves the dissociation of factors that retain it in the ER and the association of factors that mediate its further organelle-to-organelle movement.
Hvad er fantastisk ved HBO-serien Game of Thrones?
DEFF Research Database (Denmark)
Schubart, Rikke
2013-01-01
Blogindlæg på videnskab.dk, kaldt "Hvad er fantastisk ved HBO-serien Game of Thrones?" om HBO tv-serien Game of Thrones......Blogindlæg på videnskab.dk, kaldt "Hvad er fantastisk ved HBO-serien Game of Thrones?" om HBO tv-serien Game of Thrones...
The ER in 3-D: a multifunctional dynamic membrane network
Friedman, Jonathan R.; Voeltz, Gia K.
2011-01-01
The endoplasmic reticulum (ER) is a large, singular, membrane-bound organelle that has an elaborate 3-D structure with a diversity of structural domains. It contains regions that are flat and cisternal, ones that are highly curved and tubular, and others adapted to form contact with nearly every other organelle and with the plasma membrane. ER 3-D structure is determined by both integral ER membrane proteins and by interactions with the cytoskeleton. Here, we describe some of the factors that...
Evaluating the Potential Bioactivity of a Novel Compound ER1626
Wang, Lijun; Zeng, Yanyan; Wang, Tianling; Liu, Hongyi; Xiao, Hong; Xiang, Hua
2014-01-01
Background ER1626, a novel compound, is a derivate of indeno-isoquinoline ketone. This study was designed to evaluate the biological activity and potential anti-tumor mechanism of ER1626. Method MTT assay, scratch assay and flow cytometry were used to determine cell proliferation, cell migration and cell cycle distribution as well as cell apoptosis on human breast cancer MCF-7 cells and endometrial cancer Ishikawa cells. We also explored the antiangiogenic effect of ER1626 on HUVEC cells and ...
DEFF Research Database (Denmark)
Helms, Niels Henrik
2008-01-01
Verden kan betragtes som en skueplads med mange forskellige scener. I bidrgaet vil læseren kunne stifte bekendtskab med forskellige refleksioner over netop denne metaforik som analyseoptik i forhold til begrebet innovation. Afsættet er ønsket om at finde en måde at analysere og begrebsliggøre inn...
DEFF Research Database (Denmark)
Holdt, Susan Løvstad
seneste år fået øjnene op for tang indenfor områderne: biokemikalier og bioaktive stoffer, ekstraktion, gastronomi, produktudvikling, foder, bioraffinaderier, dyrkning osv. Men hvad er det tang kan? Dette foredrag vil vise at vi med tangdyrkning kan rykke mere bæredygtig fødevareproduktion ud på havet...
International Nuclear Information System (INIS)
Burck, Andreas
2008-01-01
This thesis describes the development of large-area magnetic calorimeters which could for example be used for the investigation of the dissociative recombination or the measurement of the Lamb-shift for hydrogenlike heavy ions. The detectors consist of two meandershaped niobium thin film pickup coils and a paramagnetic sensor. The deposition of energy in the sensor results in a temperature change and therefore in a change of magnetisation of the sensor, which can be measured by a SQUID-magnetometer with high precision. As sensormaterials a dilute alloy of gold-erbium (Au:Er) as well as silver-erbium (Ag:Er) were used. Whereas the Ag:Er-sensor was glued on the pickup coil the Au:Er-sensor was for the first time microstructured by a novel microstructuring process established in this thesis. For the characterisation of the detectors and the sensormaterials a fluorescence source and a 55 Fe source were used. The thermodynamic properties of the Au:Er-sensors thereby show promising results, as the magnetisation shows bulk properties down to 20 mK. The measurements of the signalize and the magnetisation with the detector which was equipped with a Ag:Er-sensor showed that the thermodynamic properties of the Ag:Eralloy could be fully described. Furthermore the shape of the pulses, the noise and the energy resolution of both detectors will be discussed. (orig.)
Directory of Open Access Journals (Sweden)
Hui eHan
2013-10-01
Full Text Available Mortality from liver cancer in humans is increasingly attributable to heavy or long-term alcohol consumption. The mechanisms by which alcohol exerts its carcinogenic effect are not well understood. In this study, the role of alcohol-induced endoplasmic reticulum (ER stress response in liver cancer development was investigated using an animal model with a liver knockout of the chaperone BiP and under constitutive hepatic ER stress. Long-term alcohol and high fat diet (HFD feeding resulted in higher levels of serum alanine aminotransferase (ALT, impaired ER stress response, and higher incidence of liver tumor in older (aged 16 months knockout females than in either middle-aged (6 months knockouts or older (aged 16 months wild type females. In the older knockout females, stronger effects of the alcohol on methylation of CpG islands at promoter regions of genes involved in the ER associated degradation (ERAD were also detected. Altered expression of ERAD factors including derlin 3, Creld2 (cysteine-rich with EGF-like domains 2, Herpud1 (ubiquitin-like domain member, Wfs1 (wolfram syndrome gene, and Yod1 (deubiquinating enzyme 1 was co-present with decreased proteasome activities, increased estrogen receptor alpha variant (ERa36, and enhanced phosphorylations of ERK1/2 (extracellular signal-regulated protein kinases 1 and 2 and STAT3 (the signal transducers and activators of transcription in the older knockout female fed alcohol. Our results suggest that long-term alcohol consumption and ageing may promote liver tumorigenesis in females through interfering with DNA methylation and expression of genes involved in the ER associated degradation.
International Nuclear Information System (INIS)
Li, Yongjin; Song, Zhiguo; Li, Chen; Wan, Ronghua; Qiu, Jianbei; Yang, Zhengwen; Yin, Zhaoyi; Yang, Yong; Zhou, Dacheng; Wang, Qi
2013-01-01
Under 980 nm excitation, high multi-photon upconversion (UC) emission from the 2 H 11/2 / 4 S 3/2 (green) and 4 F 9/2 (red) levels of Er 3+ ions were observed from Er 3+ singly doped BiOCl microcrystals. These high-energy excited states were populated by a three to ten photon UC process conditionally, which depended on the pump power density and the Er 3+ ion doping concentration, characterizing as a hetero-looping enhanced energy transfer avalanche UC process. UC emission lifetime and Raman analysis suggest that the unusual UC phenomena are initiated by the new and intense phonon vibration modes of BiOCl lattices due to Er 3+ ions doping
Synthesis and cathodoluminescence characterization of ZrO2:Er3+ films
International Nuclear Information System (INIS)
Martínez-Hernández, A.; Guzmán-Mendoza, J.; Rivera-Montalvo, T.; Sánchez-Guzmán, D.; Guzmán-Olguín, J.C.; García-Hipólito, M.; Falcony, C.
2014-01-01
Trivalent erbium doped zirconium oxide films were deposited by the ultrasonic spray pyrolysis technique. Films were deposited using zirconium tetrachloride octahydrate (ZrCl 4 O·8H 2 O) and erbium nitrate hexahydrate ((NO 3 ) 3 Er·6H 2 O) as precursors and deionized water as solvent. The dopant concentrations in the spray solution were 1, 3, 5, 10 and 15 at% in ratio to zirconium content. The films were deposited on corning glass substrates at different temperatures from 400 up to 550 °C. Films deposited at temperatures lower than 400 °C were amorphous, however, as substrate temperatures are increased, the ZrO 2 films presented a better crystallinity and showed a tetragonal phase. Cathodoluminescence (CL) emission spectra showed bands centred at 524, 544 and 655 nm associated with the electronic transition of Er 3+ . - Highlights: • The films of ZrO 2 :Er 3+ were obtained by spray pyrolysis. • Emission spectra of ZrO 2 :Er 3+ films were reported. • Cathodoluminescence of ZrO 2 :Er 3+ films was analyzed. • Cathodoluminescence of ZrO 2 :Er 3+ films showed strong dependence on substrate temperature and electron voltage
A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis.
Joshi, Amit S; Huang, Xiaofang; Choudhary, Vineet; Levine, Tim P; Hu, Junjie; Prinz, William A
2016-11-21
Saccharomyces cerevisiae contains three conserved reticulon and reticulon-like proteins that help maintain ER structure by stabilizing high membrane curvature in ER tubules and the edges of ER sheets. A mutant lacking all three proteins has dramatically altered ER morphology. We found that ER shape is restored in this mutant when Pex30p or its homologue Pex31p is overexpressed. Pex30p can tubulate membranes both in cells and when reconstituted into proteoliposomes, indicating that Pex30p is a novel ER-shaping protein. In contrast to the reticulons, Pex30p is low abundance, and we found that it localizes to subdomains in the ER. We show that these ER subdomains are the sites where most preperoxisomal vesicles (PPVs) are generated. In addition, overproduction or deletion of Pex30p or Pex31p alters the size, shape, and number of PPVs. Our findings suggest that Pex30p and Pex31p help shape and generate regions of the ER where PPV biogenesis occurs.
Lattice sites and stability of implanted Er in FZ and CZ Si
Wahl, U; Langouche, G; Vantomme, A
1998-01-01
We report on the lattice location of $^{167}$Er in Si measured by conversion electron emission channeling. In both FZ and CZ Si, a high fraction of Er (>65%) occupies near-tetrahedral interstitial (T) sites directly following 60 keV room temperature implantation at doses of 6 $\\times 10^{12}$ cm$^{-2}$. For higher doses, the as-implanted near-T fractions of Er visible by emission channeling are smaller, due to the beginning of amorphization. Following the recovery of implantation damage at 600°C, more than 70% of Er is found on near-T sites in both FZ and CZ Si. In FZ Si, Er exhibits a remarkable thermal stability and only prolonged annealing for several hours reduces the near-T fraction. On the other hand, annealing of CZ Si at 900°C for more than 10 minutes results in the majority of Er probes in sites of very low symmetry or disordered surroundings.
ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells.
Arduino, Daniela M; Esteves, A Raquel; Domingues, A Filipa; Pereira, Claudia M F; Cardoso, Sandra M; Oliveira, Catarina R
2009-11-30
Recent studies have revealed that endoplasmic reticulum (ER) disturbance is involved in the pathophysiology of neurodegenerative disorders, contributing to the activation of the ER stress-mediated apoptotic pathway. Therefore, we investigated here the molecular mechanisms underlying the ER-mitochondria axis, focusing on calcium as a potential mediator of cell death signals. Using NT2 cells treated with brefeldin A or tunicamycin, we observed that ER stress induces changes in the mitochondrial function, impairing mitochondrial membrane potential and distressing mitochondrial respiratory chain complex Moreover, stress stimuli at ER level evoked calcium fluxes between ER and mitochondria. Under these conditions, ER stress activated the unfolded protein response by an overexpression of GRP78, and also caspase-4 and-2, both involved upstream of caspase-9. Our findings show that ER and mitochondria interconnection plays a prominent role in the induction of neuronal cell death under particular stress circumstances.
CAMEX-4 ER-2 LIGHTNING INSTRUMENT PACKAGE (LIP) V1
National Aeronautics and Space Administration — The CAMEX-4 ER-2 Lightning Instrument Package (LIP) dataset was collected by the ER-2 LIP, which allows the vector components of the electric field (i.e, Ex, Ey, Ez...
Purple perilla extracts allay ER stress in lipid-laden macrophages.
Directory of Open Access Journals (Sweden)
Sin-Hye Park
Full Text Available There is a growing body of evidence that excess lipids, hypoxic stress and other inflammatory signals can stimulate endoplasmic reticulum (ER stress in metabolic diseases. However, the pathophysiological importance and the underlying mechanisms of this phenomenon remain unknown. The current study investigated that 50 ng/ml oxidized LDL promoted unfolded protein response (UPR and ER stress in J774A1 murine macrophages, which was blocked by extracts (PPE of purple Perilla frutescens, a plant of the mint family Lamiaceae. The ER stressor tunicamycin was employed as a positive control. Treating 1-10 µg/ml oxidized LDL for 24 h elicited lipotoxic apoptosis in macrophages with obvious nuclear condensation and DNA fragmentation, which was inhibited by PPE. Tunicamycin and oxidized LDL activated and induced the UPR components of activating transcription factor 6 and ER resident chaperone BiP/Grp78 in temporal manners and such effects were blocked by ≥5 µg/ml PPE. In addition, PPE suppressed the enhanced mRNA transcription and splicing of X-box binding protein 1 (XBP1 by tunicamycin and oxidized LDL. The protein induction and nuclear translocation of XBP1 were deterred in PPE-treated macrophages under ER stress. The induction of ATP-binding cassette transporter A1 (ABCA1, scavenger receptor-B1 (SR-B1 and intracellular adhesion molecule-1 (ICAM-1 was abolished by the ER stressor in activated macrophages. The protein induction of ABCA1 and ICAM1 but not SR-B1 was retrieved by adding 10 µg/ml PPE to cells. These results demonstrate that PPE inhibited lipotoxic apoptosis and demoted the induction and activation of UPR components in macrophages. PPE restored normal proteostasis in activated macrophages oxidized LDL. Therefore, PPE was a potent agent antagonizing macrophage ER stress due to lipotoxic signals associated with atherosclerosis.
ER phospholipid composition modulates lipogenesis during feeding and in obesity.
Rong, Xin; Wang, Bo; Palladino, Elisa Nd; de Aguiar Vallim, Thomas Q; Ford, David A; Tontonoz, Peter
2017-10-02
Sterol regulatory element-binding protein 1c (SREBP-1c) is a central regulator of lipogenesis whose activity is controlled by proteolytic cleavage. The metabolic factors that affect its processing are incompletely understood. Here, we show that dynamic changes in the acyl chain composition of ER phospholipids affect SREBP-1c maturation in physiology and disease. The abundance of polyunsaturated phosphatidylcholine in liver ER is selectively increased in response to feeding and in the setting of obesity-linked insulin resistance. Exogenous delivery of polyunsaturated phosphatidylcholine to ER accelerated SREBP-1c processing through a mechanism that required an intact SREBP cleavage-activating protein (SCAP) pathway. Furthermore, induction of the phospholipid-remodeling enzyme LPCAT3 in response to liver X receptor (LXR) activation promoted SREBP-1c processing by driving the incorporation of polyunsaturated fatty acids into ER. Conversely, LPCAT3 deficiency increased membrane saturation, reduced nuclear SREBP-1c abundance, and blunted the lipogenic response to feeding, LXR agonist treatment, or obesity-linked insulin resistance. Desaturation of the ER membrane may serve as an auxiliary signal of the fed state that promotes lipid synthesis in response to nutrient availability.
Time response model of ER fluids for precision control of motors
Energy Technology Data Exchange (ETDEWEB)
Koyanagi, Ken' ichi [Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama (Japan)], E-mail: koyanagi@pu-toyama.ac.jp
2009-02-01
For improvement of control performance or new control demands of mechatronics devices using particle type ER fluids, it will be needed to further investigate a response time of the fluids. It is commonly said around 5-mili seconds, however, the formula structure of that delay has not been clear. This study aims to develop a functional damper (attenuators), that can control its viscous characteristics in real time using ER fluids as its working fluid. ER dampers are useful to accomplish high precision positioning not to prevent high speed movement of the motor. To realize the functional damper that can be manipulated according to situations or tasks, the modeling and control of ER fluids are necessary. This paper investigates time delay affects of ER fluids and makes an in-depth dynamic model of the fluid by utilizing simulation and experiment. The mathematical model has a dead-time and first ordered delays of the fluid and the high voltage amplifier for the fluid.
Spectral properties of Er3+/Yb3+ codoped tungsten-tellurite glasses.
Shen, Xiang; Nie, QiuHua; Xu, TieFeng; Gao, Yuan
2005-07-01
The spectral properties of Er3+/Yb3+ codoped tungsten-tellurite (WT) glasses have been investigated. The measured absorption spectra are analyzed by Judd-Ofelt theory. The compositional change of intensity parameter omega2 is attributed to the change in the covalency between the Er3+ and oxygen ions, the asymmetry in the local structures around the Er3+ ions can be neglected. The lifetimes of 4I(13/2) level of Er3+ in WT glasses are measured and comparable with other TeO2-based glasses. The stimulated emission cross-section is calculated based on McCumber theory. The fluorescence full width at half maximum (FWHM) and the emission cross-section (sigma(peak)) of the 4I(13/2) --> 4I(15/2) transition of Er3+ in different glass hosts have been compared. The suitability of such WT glasses as host materials for 1.5 microm broadband amplification is discussed.
Optical characterization of Er-implanted ZnO films formed by sol-gel method
International Nuclear Information System (INIS)
Fukudome, T.; Kaminaka, A.; Isshiki, H.; Saito, R.; Yugo, S.; Kimura, T.
2003-01-01
In this paper, we report on the 1.54 μm photoluminescence (PL) of Er-implanted ZnO thin films formed by a sol-gel method on Si substrates. In spite of the polycrystalline structure of the sol-gel ZnO thin films, they showed strong PL emissions due to the near band edge recombination at 375 nm as well as the Er-related luminescence at 1.54 μm. The Er-related luminescence showed no decrease (quench) in the intensity up to the Er concentration of 1.5 x 10 21 cm -3 . The PL intensity of Er-implanted ZnO at 1.54 μm was found to be as strong as Er-doped PS (porous Si) at 20 K, and the intensity reduced to 1/3 at room temperature
Giv Kejseren hvad Kejserens er - på langt sigt
DEFF Research Database (Denmark)
Sestoft, Carsten
2007-01-01
Fra OECD over EU til det danske videnskabsministerium er der en mængde magtfulde instanser, som i det seneste årti har stillet en række nye krav til universiteterne. Kravene kan i korthed sammenfattes som en fordring om samfundsmæssig og økonomisk relevans. Artiklen argumenterer for, at det er le...
Improving the photoluminescence response of Er-Tm: Al2O3 films by Yb codoping
International Nuclear Information System (INIS)
Xiao Zhisong; Serna, R.; Afonso, C.N.; Cheng Guoan; Vickridge, I.
2007-01-01
Amorphous Al 2 O 3 films doped with Er, Tm and Yb have been prepared by pulsed laser deposition. A broadband emission in the range 1400-1700 nm with two peaks around 1540 and 1640 nm has been observed, both in the Er-Tm and Er-Tm-Yb codoped films. The Tm-related photoluminescence (PL) intensity at 1640 nm is enhanced when codoping with Yb thus suggesting the existence of multiple energy transfer processes from Yb to Er and Er to Tm. The Er-Tm-Yb codoped film exhibits a broadband emission with a full-width half-maximum of 184 nm similar to that of the film codoped with Tm and Er but having higher Tm to Er concentration ratio and higher PL lifetime values
Bekæmpelse af social dumping er også en kommunal opgave
DEFF Research Database (Denmark)
Baadsgaard, Kelvin; Jørgensen, Henning
2018-01-01
Kommunal indsats mod social dumping er en væsentlig del af den samlede indsats, og en evaluering af Københavns Kommunes indsats har givet indsigt i nogle af betingelserne for at få effektiviseret en sådan. Dette er også fulgt op politisk.......Kommunal indsats mod social dumping er en væsentlig del af den samlede indsats, og en evaluering af Københavns Kommunes indsats har givet indsigt i nogle af betingelserne for at få effektiviseret en sådan. Dette er også fulgt op politisk....
ER stress, autophagy, and RNA viruses
Directory of Open Access Journals (Sweden)
Jia-Rong eJheng
2014-08-01
Full Text Available Endoplasmic reticulum (ER stress is a general term for representing the pathway by which various stimuli affect ER functions. ER stress induces the evolutionarily conserved signaling pathways, called the unfolded protein response (UPR, which compromises the stimulus and then determines whether the cell survives or dies. In recent years, ongoing research has suggested that these pathways may be linked to the autophagic response, which plays a key role in the cell’s response to various stressors. Autophagy performs a self-digestion function, and its activation protects cells against certain pathogens. However, the link between the UPR and autophagy may be more complicated. These two systems may act dependently, or the induction of one system may interfere with the other. Experimental studies have found that different viruses modulate these mechanisms to allow them to escape the host immune response or, worse, to exploit the host’s defense to their advantage; thus, this topic is a critical area in antiviral research. In this review, we summarize the current knowledge about how RNA viruses, including influenza virus, poliovirus, coxsackievirus, enterovirus 71, Japanese encephalitis virus, hepatitis C virus, and dengue virus, regulate these processes. We also discuss recent discoveries and how these will produce novel strategies for antiviral treatment.
IRE1: ER stress sensor and cell fate executor.
Chen, Yani; Brandizzi, Federica
2013-11-01
Cells operate a signaling network termed the unfolded protein response (UPR) to monitor protein-folding capacity in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs. Convergent and divergent IRE1 characteristics between plants and animals underscore its significance in cellular homeostasis. This review provides an updated scenario of the IRE1 signaling model, discusses emerging IRE1 sensing mechanisms, compares IRE1 features among species, and outlines exciting future directions in UPR research. Copyright © 2013 Elsevier Ltd. All rights reserved.
Vækstplan DK er en snuptagsløsning
DEFF Research Database (Denmark)
Boje Rasmussen, Martin Møller
2013-01-01
Med Vækstplan DK har Helle Thorning-Schmidt glemt en socialdemokratisk kongstanke i ambitionen om at skyde hurtig genvej til genvalg. Planen er først og fremmest udtryk for kortsigtet finanspolitik og ikke langsigtet konkurrenceevnepolitik.......Med Vækstplan DK har Helle Thorning-Schmidt glemt en socialdemokratisk kongstanke i ambitionen om at skyde hurtig genvej til genvalg. Planen er først og fremmest udtryk for kortsigtet finanspolitik og ikke langsigtet konkurrenceevnepolitik....
Er:YAG Laser Dental Treatment of Patients Affected by Epidermolysis Bullosa
Directory of Open Access Journals (Sweden)
Angela Galeotti
2014-01-01
Full Text Available Aim. The purpose of this study was to evaluate the efficacy of Er:YAG laser used for treating hard dental tissue in patients with epidermolysis bullosa (EB. Methods. We report two cases of EB in which an Er:YAG laser was used for conservative treatments. In the first case, the Er:YAG laser (2,940 μm, 265 mJ, 25 Hz was used to treat caries on a deciduous maxillary canine in an 8-year-old male patient affected by dystrophic EB. In the second case, we treated a 26-year-old female patient, affected by junctional EB, with generalized enamel hypoplasia, and an Er:YAG laser (2,940 μm, 265 mJ, 25 Hz was used to remove the damaged enamel on maxillary incisors. Results. The use of the Er:YAG laser, with the appropriate energy, was effective in the selective removal of carious tissue and enamel hypoplasia. During dental treatment with the Er:YAG laser, patients required only a few interruptions due to the absence of pain, vibration, and noise. Conclusions. Laser treatment of hard dental tissues is a valuable choice for patients affected by EB since it is less invasive compared to conventional treatment, resulting in improved patient compliance.
BP1 Homeoprotein Enhances Metastatic Potential in ER-negative Breast Cancer
Fu, Yebo; Lian, Yi; Kim, Kyung Soon; Zhang, Lei; Hindle, A. Katharine; Brody, Fred; Siegel, Robert S.; McCaffrey, Timothy A.; Fu, Sidney W.
2010-01-01
Tumor invasion and metastasis remain a major cause of mortality in breast cancer patients. It was reported that BP1, a homeobox isoform of DLX4, is overexpressed in 80% of breast cancer patients and in 100% of estrogen receptor negative (ER-) tumors. The prevalence of BP1 positive cells and the intensity of BP1 immunoreactivity increased with the extent of ductal proliferation and tumorigenesis. These findings imply that BP1 may play an important role in ER- breast cancer. We sought to determine the effects and mechanisms of BP1 on cell proliferation and metastasis using ER- Hs578T cells as a model. Cells were transfected with either pcDNA3.2 plasmid containing BP1 gene, or pcDNA3.2 vector, then selected and cloned. Overexpression of BP1 increased cell proliferation rate by 2-5 fold (p=2.0. Of those genes, 49 were up-regulated and 22 were down-regulated. Significant pathways were identified involving cell proliferation and metastasis. These data demonstrated that overexpression of BP1 significantly enhanced cell proliferation and metastatic potential in ER- Hs578T cells. Further analysis with more ER- cell lines and patient samples is warranted to establish BP1 as a therapeutic target for ER- breast cancer. PMID:20842225
Energy Technology Data Exchange (ETDEWEB)
Murasik, A. E-mail: amur@cyf.gov.pl; Czopnik, A. E-mail: czopnik@int.pan.wroc.pl; Keller, L. E-mail: lukas.keller@psi.ch; Fischer, P. E-mail: peter.fischer@psi.ch
2000-04-01
The magnetic phase diagram of ErGa{sub 3}, built up from bulk magnetisation data, shows in zero-applied magnetic field two successive transitions at T{sub 1}=2.6 and T{sub 2} congruent with 2.8 K, respectively. The magnetic ordering of ErGa{sub 3} examined by neutron diffraction, can be derived from the so-called {l_brace}((1)/(2)), ((1)/(2)), 0{r_brace} structure, i.e. one in which the successive antiparallel (1 1 0) sheets of spins have additionally superimposed on them a sinusoidal modulation parallel to the [1 0 0] axis. The temperature dependence of neutron diffraction diagrams studied on the single crystal, revealed in the range of (2.6-2.78) K an abrupt reorientation of the Er{sup 3+} spins from the nearly [1 1 0] direction, towards the [1 0 0] axis. In this way previously observed effect on the polycrystalline sample has been confirmed. This rotation can be attributed to the T{sub 1} transition found in the H-T magnetic phase diagram.
Sraka, Petra
2011-01-01
V diplomskem delu so predstavljeni didaktični pripomočki na splošno, sledi pregled terminov, ki so se zanje uporabljali skozi zgodovino vse do danes, klasifikacija ter lastnosti temeljnih didaktičnih pripomočkov. Podane so osnovne smernice kritične izbire ter racionalne uporabe pripomočkov pri pouku matematike. Bolj podrobno so predstavljeni didaktični pripomočki pri pouku matematike v sklopu aritmetike in algebre v prvem triletju osnovne šole oziroma tisti pripomočki, ki jih predpisuje učni ...
Ny vaccine mod ledbetændelse er ikke effektiv
DEFF Research Database (Denmark)
Nielsen, Elisabeth Okholm; Lauritsen, Klara Tølbøll
2013-01-01
En ny mulighed for at vaccinere mod mykoplasma-ledbetændelse er undersøgt hos en slagtesvineproducent. Vaccinen kunne desværre ikke forebygge halthed eff ektivt.......En ny mulighed for at vaccinere mod mykoplasma-ledbetændelse er undersøgt hos en slagtesvineproducent. Vaccinen kunne desværre ikke forebygge halthed eff ektivt....
Den radikale Kings skandinaviske drøm
DEFF Research Database (Denmark)
Brøndal, Jørn
2013-01-01
I dag forgudes Martin Luther King for sin racemæssige vision. Derimod aner de fleste amerikanere ikke noget om hans økonomiske ideer, og hvis de gjorde, ville mange af dem utvivlsomt affeje dem som alt for radikale......I dag forgudes Martin Luther King for sin racemæssige vision. Derimod aner de fleste amerikanere ikke noget om hans økonomiske ideer, og hvis de gjorde, ville mange af dem utvivlsomt affeje dem som alt for radikale...
Hydrothermal synthesis and characteristic photoluminescence of Er-doped SnO{sub 2} nanoparticles
Energy Technology Data Exchange (ETDEWEB)
Tuan, Pham Van; Hieu, Le Trung; Nga, La Quynh [International Training Institute for Materials Science, Hanoi University of Science and Technology, No.1, Dai Co Viet, Hanoi (Viet Nam); Dung, Nguyen Duc [Advanced Institute of Science and Technology, Hanoi University of Science and Technology, No.1, Dai Co Viet, Hanoi (Viet Nam); Ha, Ngo Ngoc [International Training Institute for Materials Science, Hanoi University of Science and Technology, No.1, Dai Co Viet, Hanoi (Viet Nam); Khiem, Tran Ngoc, E-mail: khiem@itims.edu.vn [International Training Institute for Materials Science, Hanoi University of Science and Technology, No.1, Dai Co Viet, Hanoi (Viet Nam)
2016-11-15
We report the characteristic photoluminescence (PL) spectra of erbium ion (Er{sup 3+})-doped tin dioxide (SnO{sub 2})nanoparticles. The materials were prepared via hydrothermal method at 180 °C with in 20 h by using various Er{sup 3+} ion concentrations ranging from 0.0 to 1.0 at%. After the synthesis, the materials were characterized through X-ray diffraction and high-resolution transmission electron microscopy. Crystallite SnO{sub 2} and its average particle diameter of approximately 5 nm did not change with Er{sup 3+} ion dopant concentration. Photoluminescence spectra showed the characteristic light emission from the Er{sup 3+} ions. The PL excitation spectra referred to an efficient energy transfer to Er{sup 3+} ions in the presence of SnO{sub 2}nanoparticles. The most intense Er-related emission of SnO{sub 2}:Er{sup 3+} nanoparticles in near infrared region was found in samples containing an Er{sup 3+} ion concentration of 0.25 at%. Although the absorption bandgaps of the materials were identified at approximately 3.8 eV, we found that efficient excitation comes with low excitation energy band edge. Excitation is possibly involved in shallow defects in SnO{sub 2} nanoparticles.
Plate, Lars; Cooley, Christina B; Chen, John J; Paxman, Ryan J; Gallagher, Ciara M; Madoux, Franck; Genereux, Joseph C; Dobbs, Wesley; Garza, Dan; Spicer, Timothy P; Scampavia, Louis; Brown, Steven J; Rosen, Hugh; Powers, Evan T; Walter, Peter; Hodder, Peter; Wiseman, R Luke; Kelly, Jeffery W
2016-01-01
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UPR)-associated transcription factor ATF6 attenuates secretion and extracellular aggregation of amyloidogenic proteins. Here, we employed a screening approach that included complementary arm-specific UPR reporters and medium-throughput transcriptional profiling to identify non-toxic small molecules that phenocopy the ATF6-mediated reprogramming of the ER proteostasis environment. The ER reprogramming afforded by our molecules requires activation of endogenous ATF6 and occurs independent of global ER stress. Furthermore, our molecules phenocopy the ability of genetic ATF6 activation to selectively reduce secretion and extracellular aggregation of amyloidogenic proteins. These results show that small molecule-dependent ER reprogramming, achieved through preferential activation of the ATF6 transcriptional program, is a promising strategy to ameliorate imbalances in ER function associated with degenerative protein aggregation diseases. DOI: http://dx.doi.org/10.7554/eLife.15550.001 PMID:27435961
Er internethandel kommet for at blive? Eller er det bare krisen som kradser?
DEFF Research Database (Denmark)
Ivang, Reimer
2012-01-01
I de seneste dage har Jyllandsposten sat fokus på, at omsætningen i den danske detailhandel falder, der fyres, der spares, og det bliver endnu værre i de kommende måneder og år. I artiklen udråbes finanskrisen, som den store skurk, men er det nu den fulde sandhed?...
Luminescence properties and energy transfer processes in YAG:Yb,Er single crystalline films
International Nuclear Information System (INIS)
Zorenko, Yu.; Gorbenko, V.; Savchyn, V.; Batentschuk, M.; Osvet, A.; Brabec, C.
2013-01-01
The paper is dedicated to the study of the optical properties of YAG:Yb,Er single-crystalline films (SCF) grown by liquid phase epitaxy. The absorption, cathodoluminescence and time-resolved photoluminescence spectra and photoluminescence decay curves were measured for the SCFs with different doping levels of Er 3+ (from 0.6 to 4.2 at.%) and Yb 3+ (from 0.1 to 0.6 at.%). The spectra, excited by synchrotron radiation in the fundamental absorption range of the YAG and in the intraionic absorption bands of both dopants, reveal energy transfer from the YAG host to the Er 3+ and Yb 3+ ions and between these ions. -- Highlights: •Growth of YAG:Yb,Er single crystalline films by LPE method. •Peculiarities of luminescence of YAG:Yb,Er films with different Er–Yb content. •Yb–Er energy transfer processes in YAG hosts
Optical excitation of Er centers in GaN epilayers grown by MOCVD
George, D. K.; Hawkins, M. D.; Jiang, H. X.; Lin, J. Y.; Zavada, J. M.; Vinh, N. Q.
2016-02-01
In this paper we present results of photoluminescence (PL), photoluminescence excitation (PLE), and time resolved PL spectroscopy of the 4I13/2 → 4I15/2 transition in Er optical centers in GaN epilayers grown by metal-organic chemical vapor deposition. Under resonance excitation via the higher-lying inner 4f shell transitions and band-to-band excitation of the semiconductor host, the PL and PLE spectra reveal an existence of two types of Er optical centers from isolated and the defect-related Er centers in GaN epilayers. These centers have different PL spectra, local defect environments, decay dynamics, and excitation cross-sections. The isolated Er optical center, which can be excited by either excitation mechanism, has the same decay dynamics, but possesses a much higher cross-section under band-to-band excitation. In contrast, the defect-related Er center can only be observed through band-to-band excitation but has the largest crosssection. Our results indicate pathways for efficient optical excitation of Er-doped GaN semiconductors.
Generation of ER{alpha}-floxed and knockout mice using the Cre/LoxP system
Energy Technology Data Exchange (ETDEWEB)
Antonson, P., E-mail: per.antonson@ki.se [Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE-141 83 Huddinge (Sweden); Omoto, Y.; Humire, P. [Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE-141 83 Huddinge (Sweden); Gustafsson, J.-A. [Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE-141 83 Huddinge (Sweden); Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 (United States)
2012-08-10
Highlights: Black-Right-Pointing-Pointer ER{alpha} floxed and knockout mice were generated. Black-Right-Pointing-Pointer Disruption of the ER{alpha} gene results in sterility in both male and female mice. Black-Right-Pointing-Pointer ER{alpha}{sup -/-} mice have ovaries with hemorrhagic follicles and hypoplastic uterus. Black-Right-Pointing-Pointer Female ER{alpha}{sup -/-} mice develop obesity. -- Abstract: Estrogen receptor alpha (ER{alpha}) is a nuclear receptor that regulates a range of physiological processes in response to estrogens. In order to study its biological role, we generated a floxed ER{alpha} mouse line that can be used to knock out ER{alpha} in selected tissues by using the Cre/LoxP system. In this study, we established a new ER{alpha} knockout mouse line by crossing the floxed ER{alpha} mice with Cre deleter mice. Here we show that genetic disruption of the ER{alpha} gene in all tissues results in sterility in both male and female mice. Histological examination of uterus and ovaries revealed a dramatically atrophic uterus and hemorrhagic cysts in the ovary. These results suggest that infertility in female mice is the result of functional defects of the reproductive tract. Moreover, female knockout mice are hyperglycemic, develop obesity and at the age of 4 months the body weight of these mice was more than 20% higher compared to wild type littermates and this difference increased over time. Our results demonstrate that ER{alpha} is necessary for reproductive tract development and has important functions as a regulator of metabolism in females.
Inflation er en af finanskrisens løsninger
DEFF Research Database (Denmark)
Boje Rasmussen, Martin Møller
2013-01-01
Med en lille anekdote om børnepasning illustrerer den amerikanske stjerneøkonom Paul Krugman, hvorfor økonomiske recessioner opstår, og hvad vi bør stille op over for dem. Inflation er et af svarene.......Med en lille anekdote om børnepasning illustrerer den amerikanske stjerneøkonom Paul Krugman, hvorfor økonomiske recessioner opstår, og hvad vi bør stille op over for dem. Inflation er et af svarene....
Planar waveguide laser in Er/Al-doped germanosilicate
DEFF Research Database (Denmark)
Guldberg-Kjær, Søren Andreas; Hübner, Jörg; Kristensen, Martin
1999-01-01
A singlemode DBR laser is demonstrated in an Er/Al-doped germanosilicate planar waveguide. 0.4 mW of output power has been obtained at 1.553 mu m using internal Bragg reflectors produced by UV-induced index modulations.......A singlemode DBR laser is demonstrated in an Er/Al-doped germanosilicate planar waveguide. 0.4 mW of output power has been obtained at 1.553 mu m using internal Bragg reflectors produced by UV-induced index modulations....
Next generation Er:YAG fractional ablative laser
Heinrich, A.; Vizhanyo, A.; Krammer, P.; Summer, S.; Gross, S.; Bragagna, T.; Böhler, C.
2011-03-01
Pantec Biosolutions AG presents a portable fractional ablative laser system based on a miniaturized diode pumped Er:YAG laser. The system can operate at repetition rates up to 500 Hz and has an incorporated beam deflection unit. It is smaller, lighter and cost efficient compared to systems based on lamp pumped Er:YAG lasers and incorporates a skin layer detection to guarantee precise control of the microporation process. The pulse parameters enable a variety of applications in dermatology and in general medicine, as demonstrated by first results on transdermal drug delivery of FSH (follicle stimulating hormone).
Sodahvede og glycerol til malkekøer
DEFF Research Database (Denmark)
Hvelplund, Torben; Weisbjerg, Martin Riis
2011-01-01
Et fodringsforsøg på Kvægbrugets Forsøgscenter har vist, at glycerol kan anvendes som et alternativt fodermiddel til højtydende malkekøer. De anvendte mængder gav dog en lavere EKM ydelse end sodahvede, men øgede samtidigt mælkens proteinindhold.......Et fodringsforsøg på Kvægbrugets Forsøgscenter har vist, at glycerol kan anvendes som et alternativt fodermiddel til højtydende malkekøer. De anvendte mængder gav dog en lavere EKM ydelse end sodahvede, men øgede samtidigt mælkens proteinindhold....
Jordkvalitetskriterier for PAH'er
DEFF Research Database (Denmark)
Carlsen, Lars
2009-01-01
For to år siden forhøjede Miljøstyrelsen den administrativt fastsatte grænseværdi for polycycliske hydrocarboner (PAH’er) i jord med en faktor 3, hvilket i praksis betød at en række grunde, der tidligere var klassifi ceret som forurenede, nu ikke klassifi ceres sådan. Den hidtidige og den nye met...
Study of thermal treated a-Si implanted with Er and O ions
Plugaru, R; Piqueras, J; Tate, T J
2002-01-01
Visible luminescence of amorphous silicon layers either implanted with Er or co-implanted with Er and O and subsequently annealed in nitrogen has been investigated by cathodoluminescence (CL) in a scanning electron microscope. Co-implanted samples show a more intense luminescence, which is revealed by annealing at lower temperatures than the samples implanted only with erbium. Thermal treatments cause the formation of erbium oxide as well as Er-Si complexes or precipitates. Violet-blue luminescence has been found from CL images and spectra to be related to Er-Si precipitates. Emission in the green-red range is attributed to oxide species.
Kommunen er død - længe leve den digitale disruption
DEFF Research Database (Denmark)
Andersen, Kim Normann
2017-01-01
"New Public Management is Dead. Long Live the Digital Era." Sådan proklamerede Patrick Donleavy digitaliseringens muligheder i en banebrydende artikel fra 2005. Med en omskrivning af dette citat til "Kommunen er død, længe leve den digitale disruption", er ballet åbnet for denne artikel......."New Public Management is Dead. Long Live the Digital Era." Sådan proklamerede Patrick Donleavy digitaliseringens muligheder i en banebrydende artikel fra 2005. Med en omskrivning af dette citat til "Kommunen er død, længe leve den digitale disruption", er ballet åbnet for denne artikel....
Expression profiling on soybean leaves reveals integration of ER- and osmotic-stress pathways
Directory of Open Access Journals (Sweden)
Dewey Ralph E
2007-11-01
Full Text Available Abstract Background Despite the potential of the endoplasmic reticulum (ER stress response to accommodate adaptive pathways, its integration with other environmental-induced responses is poorly understood in plants. We have previously demonstrated that the ER-stress sensor binding protein (BiP from soybean exhibits an unusual response to drought. The members of the soybean BiP gene family are differentially regulated by osmotic stress and soybean BiP confers tolerance to drought. While these results may reflect crosstalk between the osmotic and ER-stress signaling pathways, the lack of mutants, transcriptional response profiles to stresses and genome sequence information of this relevant crop has limited our attempts to identify integrated networks between osmotic and ER stress-induced adaptive responses. As a fundamental step towards this goal, we performed global expression profiling on soybean leaves exposed to polyethylene glycol treatment (osmotic stress or to ER stress inducers. Results The up-regulated stress-specific changes unmasked the major branches of the ER-stress response, which include enhancing protein folding and degradation in the ER, as well as specific osmotically regulated changes linked to cellular responses induced by dehydration. However, a small proportion (5.5% of total up-regulated genes represented a shared response that seemed to integrate the two signaling pathways. These co-regulated genes were considered downstream targets based on similar induction kinetics and a synergistic response to the combination of osmotic- and ER-stress-inducing treatments. Genes in this integrated pathway with the strongest synergistic induction encoded proteins with diverse roles, such as plant-specific development and cell death (DCD domain-containing proteins, an ubiquitin-associated (UBA protein homolog and NAC domain-containing proteins. This integrated pathway diverged further from characterized specific branches of ER-stress as
International Nuclear Information System (INIS)
Němec, M; Šulc, J; Indra, L; Fibrich, M; Jelínková, H
2015-01-01
Er:YAG crystal was investigated as the gain medium in a diode (1452 nm) pumped tunable laser. The tunability was reached in an eye-safe region by an intracavity birefringent filter. The four tuning bands were obtained peaking at wavelengths 1616, 1632, 1645, and 1656 nm. The broadest continuous tunability was 6 nm wide peaking at 1616 nm. The laser was operating in a pulsed regime (10 ms pulse length, 10 Hz repetition rate). The maximum mean output power was 26.5 mW at 1645 nm. The constructed system demonstrated the tunability of a resonantly diode-pumped Er:YAG laser which could be useful in the development of compact diode-pumped lasers for spectroscopic applications. (paper)
Energy Technology Data Exchange (ETDEWEB)
Choe, Sung-Hyu [Chosun University, Kwangju (Korea, Republic of); Jin, Moon-Seog [Dongshin University, Naju (Korea, Republic of); Kim, Wha-Tek [Chonnam National University, Kwangju (Korea, Republic of)
2005-12-15
BaGa{sub 2}S{sub 4}:Er{sup 3+} and BaGa{sub 2}Se{sub 4}:Er{sup 3+} single crystals were grown by using the chemical transport reaction method. The optical energy gaps of the BaGa{sub 2}S{sub 4}:Er{sup 3+} and the BaGa{sub 2}Se{sub 4}:Er{sup 3+} single crystals were found to be 4.045 eV and 3.073 eV, respectively, at 11 K. The temperature dependence of the optical energy gap was well fitted by the Varshni equation. Sharp emission peaks were observed in the photoluminescence spectra of the single crystals and assigned to radiation recombination between split Stark levels of the Er{sup 3+} ion.
ER network homeostasis is critical for plant endosome streaming and endocytosis
Stefano, Giovanni; Renna, Luciana; Lai, YaShiuan; Slabaugh, Erin; Mannino, Nicole; Buono, Rafael A; Otegui, Marisa S; Brandizzi, Federica
2015-01-01
Eukaryotic cells internalize cargo at the plasma membrane via endocytosis, a vital process that is accomplished through a complex network of endosomal organelles. In mammalian cells, the ER is in close association with endosomes and regulates their fission. Nonetheless, the physiological role of such interaction on endocytosis is yet unexplored. Here, we probed the existence of ER–endosome association in plant cells and assayed its physiological role in endocytosis. Through live-cell imaging and electron microscopy studies, we established that endosomes are extensively associated with the plant ER, supporting conservation of interaction between heterotypic organelles in evolutionarily distant kingdoms. Furthermore, by analyzing ER–endosome dynamics in genetic backgrounds with defects in ER structure and movement, we also established that the ER network integrity is necessary for homeostasis of the distribution and streaming of various endosome populations as well as for efficient endocytosis. These results support a novel model that endocytosis homeostasis depends on a spatiotemporal control of the endosome dynamics dictated by the ER membrane network. PMID:27462431
Wealth of information derivable from Evaporation Residue (ER) angular momentum distributions
International Nuclear Information System (INIS)
Madhavan, N.
2016-01-01
Understanding fusion-fission dynamics is possible by studying the fission process, or, alternatively, by studying the complementary fusion-evaporation process. Though the latter method is difficult to implement, requiring sophisticated recoil separators/spectrometers for selecting the ERs in the direction of the primary beam, it provides more clarity with better accuracy and is indispensible for probing the pre-saddle region in heavy nuclei. Super Heavy Element (SHE) search crucially depends on understanding the fusion-fission process, the choice of entrance channel and excitation energy of the Compound Nucleus (CN), ER cross-section and, more importantly, the angular momenta populated in ERs which survive fission. The measurement of ER angular momentum distributions, through coincidence technique involving large gamma multiplicity detector array and recoil separator, throws up a wealth of information such as, nuclear viscosity effects, limits of stability of ERs, shape changes at high spins, snapshot of frozen set of barriers using a single-shot experiment and indirect information about onset of quasi-fission processes. There is a paucity of experimental data with regard to angular momentum distributions in heavy nuclei due to experimental constraints. In this talk, the variety of information which could be derived through experimental ER angular momentum distributions will be elaborated with examples from work carried out at IUAC using advanced experimental facilities. (author)
Scintillation properties of Er-doped Y3Al5O12 single crystals
International Nuclear Information System (INIS)
Yamaji, Akihiro; Ogino, Hiraku; Fujimoto, Yutaka; Suzuki, Akira; Yanagida, Takayuki; Yokota, Yuui; Kurosawa, Shunsuke; Yoshikawa, Akira
2013-01-01
Er-doped Y 3 Al 5 O 12 single crystals with different Er concentrations of 0.1, 1.0, 10, 30, and 50% were grown by the micro-pulling down method. There were several absorption lines due to the Er 3+ 4f-4f transitions in the transmittance spectra and these lines correspond to the transitions from the ground state of 4 I 15/2 to the excited states. The photo- and radio-luminescence spectra showed Er 3+ 4f-4f emissions. Relative light yield under 5.5 MeV alpha-ray irradiation of Er 0.1%:Y 3 Al 5 O 12 was estimated to be 63% of that of Bi 4 Ge 3 O 12 . -- Highlights: •Er doped Y 3 Al 5 O 12 single crystal scintillators were grown with different Er concentrations. •Optical properties associated with 4f-4f transition were evaluated. •Radio luminescence spectra measurements were performed under 5.5 MeV alpha-ray irradiation. •The highest light yield was estimated to be 63% of that of Bi 4 Ge 3 O 12 under 5.5 MeV alpha-ray irradiation
Structural and Functional Impacts of ER Coactivator Sequential Recruitment.
Yi, Ping; Wang, Zhao; Feng, Qin; Chou, Chao-Kai; Pintilie, Grigore D; Shen, Hong; Foulds, Charles E; Fan, Guizhen; Serysheva, Irina; Ludtke, Steven J; Schmid, Michael F; Hung, Mien-Chie; Chiu, Wah; O'Malley, Bert W
2017-09-07
Nuclear receptors recruit multiple coactivators sequentially to activate transcription. This "ordered" recruitment allows different coactivator activities to engage the nuclear receptor complex at different steps of transcription. Estrogen receptor (ER) recruits steroid receptor coactivator-3 (SRC-3) primary coactivator and secondary coactivators, p300/CBP and CARM1. CARM1 recruitment lags behind the binding of SRC-3 and p300 to ER. Combining cryo-electron microscopy (cryo-EM) structure analysis and biochemical approaches, we demonstrate that there is a close crosstalk between early- and late-recruited coactivators. The sequential recruitment of CARM1 not only adds a protein arginine methyltransferase activity to the ER-coactivator complex, it also alters the structural organization of the pre-existing ERE/ERα/SRC-3/p300 complex. It induces a p300 conformational change and significantly increases p300 HAT activity on histone H3K18 residues, which, in turn, promotes CARM1 methylation activity on H3R17 residues to enhance transcriptional activity. This study reveals a structural role for a coactivator sequential recruitment and biochemical process in ER-mediated transcription. Copyright © 2017 Elsevier Inc. All rights reserved.
Up-conversion luminescence of Er3+/Yb3+/Nd3+-codoped tellurite glasses
International Nuclear Information System (INIS)
Lu Longjun; Nie Qiuhua; Xu Tiefeng; Dai Shixun; Shen Xiang; Zhang Xianghua
2007-01-01
Up-conversion luminescence and energy transfer (ET) processes in Nd 3+ -Yb 3+ -Er 3+ triply doped TeO 2 -ZnO-Na 2 O glasses have been studied under 800 nm excitation. Intense green up-conversion emissions around 549 nm, which can be attributed to the Er 3+ : 4 S 3/2 →4 I 15/2 transition, are observed in triply doped samples. In contrast, the green emissions are hardly observed in Er 3+ singly doped and Er 3+ -Yb 3+ codoped samples under the same condition. Up-conversion luminescence intensity exhibits dependence of Yb 2 O 3 -concentration and Nd 2 O 3 -concentration. Up-conversion mechanism in the triply doped glasses under 800 nm pump is discussed by analyzing the ET among Nd 3+ , Yb 3+ and Er 3+ . And a possible up-conversion mechanism based on sequential ET from Nd 3+ to Er 3+ through Yb 3+ is proposed for green and red up-conversion emission processes