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Sample records for marwan khaled tayeh

  1. Amir's Guilt in Khaled Hosseini's the Kite Runner

    OpenAIRE

    Lambe, Lordna G.L; Basuki, Ribut

    2013-01-01

    This paper emphasizes guilt as the main issue portrayed in Khaled Hosseini's The Kite Runner through its main character, Amir. Guilt discussed in this paper is defined as a feeling produced from a behavior that is related to a failure, a wrong doing, or even a sin. This paper discusses the way Amir deals with his guilt since it needs to be redeemed even through suffering. In this paper, I maintain that Amir bears not only his personal guilt yet also his familial and societal guilt. Amir's per...

  2. Acanthamoeba Keratitis at the King Khaled Eye Specialist Hospital

    International Nuclear Information System (INIS)

    Al-Mezaine, H.; Al-Muteb, M.; Al-Motowa, S.; Wagoner, M. D.

    2005-01-01

    To quantify the number of cases and clinical courses of Acanthamoeba keratitis treated at the King Khaled Eye Specialist Hospital (KKESH) between December 1982 and May 2005, and to review their clinical course and response to medical and surgical therapy. Retrospective review of medical records of all patients with Acanthamoeba keratitis diagnosed by the KKESH Microbiology or Pathology or Pathology Laboratory since the opening of the hospital. During a period of over 22 years, only six cases of confirmed. Acanthamoeba keratitis were diagnosedand treated at KKESH. In two cases the diagnosis was made by corneal biopsy, while four cases required examination of a histopathology specimen obtained at the time of therapeutic keratoplasty to establish the diagnosis. One eye was cured by medical therapy, while five eyes required one (4eyes) or two (1 eye) therapeutic penetrating keratoplasty (PKP) to achieve a clinical cure. Three eyes achieved good visual acuity (20/40, 20/50, 20/60), one eye achieved fair visual acuity (20/160), and two eyes suffered profound visual loss (hand motions). The incidence of Acanthamoeba keratitis may be less in Saudi Arabia than reported in Western countries although the clinical is similarly complicated, with most cases requiring therapeutic keratoplasty for definitive education of the organism. (author)

  3. Afghanistan and Multiculturalism in Khaled Hosseini's Novels: Study of Place and Diversity

    Science.gov (United States)

    Agnello, Mary F.; Todd, Reese H.; Olaniran, Bolanle; Lucey, Thomas A.

    2009-01-01

    Purpose: The purpose of this paper is to frame Khaled Hosseini's novels, "The Kite Runner" and "A Thousand Splendid Suns", as literature to expand and enhance the American secondary curriculum with multicultural themes based on Afghanistan as a geographical and cultural place in a dynamic, diverse, and complex world more…

  4. Recent and future advances in anticancer drug delivery: an interview with Khaled Greish.

    Science.gov (United States)

    Greish, Khaled

    2018-05-01

    Khaled Greish speaks to Hannah Makin, Commissioning Editor: Khaled Greish is Associate Professor of Molecular Medicine, and head of the Nano-research unit, at Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain. His previous appointments included Senior lecturer of Pharmacology at the University of Otago, New Zealand, and Assistant Professor of Pharmaceutical Chemistry at University of Utah (UT, USA). He has published >70 peer reviewed papers, and ten book chapters in the field of targeted anticancer drug delivery. Controlled Release Society (CRS) awarded him the CRS Postdoctoral Achievement Award in 2008 and in 2010; he was elected as member of the CRS College of Fellows. In recognition of his research, University of Otago awarded him "Early Career Awards for Distinction in Research" in 2014. His research focuses on nanomedicine, tumor vascular biology and anticancer drug discovery/development.

  5. Racial Discrimination Towards the Hazaras as Reflected in Khaled Hosseini's the Kite Runner

    OpenAIRE

    Handayani, Fadlilah Satya

    2016-01-01

    Khaled Hosseini's novel entitled The Kite Runner is an American bestseller novel that represents racial conflict between the Pashtuns and Hazaras, two different races and ethnics in Afghanistan. The aims of this study are to find out the causes of racial discrimination, to analyze examples of racial discrimination, and to analyze the impacts of racial discrimination as depicted in The Kite Runner. Sociological approach and theories on racism and racial discrimination are used in this study. T...

  6. Gaya Bahasa Dalam Novel Terjemahan Sang Pengejar Layang-layang (the Kite Runner) Karya Khaled Hosseini

    OpenAIRE

    Maya Setia Ekawati, Dian; Sumarwati, Sumarwati; Anindyarini, Atikah

    2012-01-01

    The purpose of this research is : (1) to describes the dominant language of style is use by Khaled Hosseini in the translation novel The Kite Runner, and (2) perception readers againt the used language of style in novel. The sampling technique used was purposive sampling. Data collection techniques used were in-depth interviews and document analysis. Data analysis technique used is the interactive analytical model that includes four components, namely data collection, data reduction, data pre...

  7. The Study of Simplification and Explicitation Techniques in Khaled Hosseini's “A Thousand Splendid Suns”

    OpenAIRE

    Reza Kafipour

    2016-01-01

    Teaching and learning strategies help facilitate teaching and learning. Among them, simplification and explicitation strategies are those which help transferring the meaning to the learners and readers of a translated text. The aim of this study was to investigate explicitation and simplification in Persian translation of novel of Khaled Hosseini's “A Thousand Splendid Suns”. The study also attempted to find out frequencies of simplification and explicitation techniques used by the translator...

  8. TELAAH HERMENEUTIKA HADITH KHALED M. ABOU EL-FADL DALAM SPEAKING GOD’S NAME: AUTHORITY AND WOMEN

    Directory of Open Access Journals (Sweden)

    Ahmad Suhendra

    2014-12-01

    Full Text Available Abstrak: Tulisan ini mengulas hermeneutika Khaled M. Abou El-Fadl, dalam karyanya berjudul Speaking God’s Name: Authority and Women. Tokoh ini menarik untuk diteliti karena teorinya itu bermula dari fakta yang dialaminya. Mulanya dia pengagum salafi, kemudian mengkritik paham tersebut. Tulisan ini memfokuskan pada pemikirannya tentang makna dan teks agama. Untuk membongkar pemikiran Khaled digunakan metode deskriptif-analitis. Ternyata, hermeneutika yang ditawarkan Khaled dipengaruhi oleh beberapa tokoh hermeneutik Barat, terutama Gadamer dan Gracia. Dari situ, dia merumuskan lima prasyarat yang harus ditempuh seseorang dalam menafsirkan teks suci agama.Abstract: This paper examines Khaled M. Abou El-Fadl’s hermeneutics in his work entitled Speaking God’s Name: Authority and Women. This figure is interesting to study because his theory stems from his own experience. At first he was an admirer salafi, but later criticizes it. This paper focuses on his thoughts about religious meaning texts and applies descriptive-analytical method. This study shows that El-Fadl’s hermeneutics is influenced by western philosopher, such as Gadamer and Gracia. He formulated a set of condition upon which one has to ground his/her interpretation of religious texts.

  9. The Subaltern Voice in A Thousand Splendid Suns by Khaled Khosseini

    Directory of Open Access Journals (Sweden)

    Soraya Soraya

    2015-11-01

    Full Text Available Life in Afghanistan puts female as the second sex and the victims of patriarchy. In the eye of Orientalism, women are the east. Thus, they can be colonized and suppressed (the subaltern. This study was designed to answer the question how was the voice of the subaltern being represented by the characters in the novel A Thousand Splendid Suns by Khaled Khosseini. Library research was applied in this study. Data were  analyzed using postcolonial theory, specifically from Gayatri Spivak. The conclusion presents that both characters, Mariam and Laila is the representation of the subaltern who created voice to fight against the oppression. Between Mariam, the symbol of traditional woman, and Laila, the symbol of modern woman, only Laila who can reach the freedom. However, it is impossible to achieve without the courage and sacrifice of Mariam 

  10. THE STUDY OF SIMPLIFICATION AND EXPLICITATION TECHNIQUES IN KHALED HOSSEINI'S “A THOUSAND SPLENDID SUNS”

    Directory of Open Access Journals (Sweden)

    Reza Kafipour

    2016-12-01

    Full Text Available Teaching and learning strategies help facilitate teaching and learning. Among them, simplification and explicitation strategies are those which help transferring the meaning to the learners and readers of a translated text. The aim of this study was to investigate explicitation and simplification in Persian translation of novel of Khaled Hosseini's “A Thousand Splendid Suns”. The study also attempted to find out frequencies of simplification and explicitation techniques used by the translators in translating the novel. To do so, 359 sentences out of 6000 sentences in original text were selected by systematic random sampling procedure. Then the percentage and total sums of each one of the strategies were calculated. The result showed that both translators used simplification and explicitation techniques significantly in their translation whereas Saadvandian, the first translator, significantly applied more simplification techniques in comparison with Ghabrai, the second translator. However, no significant difference was found between translators in the application of explicitation techniques. The study implies that these two translation strategies were fully familiar for the translators as both translators used them significantly to make the translation more understandable to the readers.

  11. The Study of Simplification and Explicitation Techniques in Khaled Hosseini's “A Thousand Splendid Suns”

    Directory of Open Access Journals (Sweden)

    Reza Kafipour

    2016-12-01

    Full Text Available Teaching and learning strategies help facilitate teaching and learning. Among them, simplification and explicitation strategies are those which help transferring the meaning to the learners and readers of a translated text. The aim of this study was to investigate explicitation and simplification in Persian translation of novel of Khaled Hosseini's “A Thousand Splendid Suns”. The study also attempted to find out frequencies of simplification and explicitation techniques used by the translators in translating the novel. To do so, 359 sentences out of 6000 sentences in original text were selected by systematic random sampling procedure. Then the percentage and total sums of each one of the strategies were calculated. The result showed that both translators used simplification and explicitation techniques significantly in their translation whereas Saadvandian, the first translator, significantly applied more simplification techniques in comparison with Ghabrai, the second translator. However, no significant difference was found between translators in the application of explicitation techniques. The study implies that these two translation strategies were fully familiar for the translators as both translators used them significantly to make the translation more understandable to the readers.

  12. Uveal melanoma in the Saudi Arabian population: Two decades of management at the King Khaled Eye Specialist Hospital

    International Nuclear Information System (INIS)

    Alsuhaibani Adel H

    2009-01-01

    To present the experience of King Khaled Eye Specialist Hospital (KKESH) with uveal melanoma over the last two decades in a fashion similar to the result of the Collaborative Ocular Melanoma Study (COMS). Retrospective, non-comparative, interventional, case series. All patients were diagnosed with uveal melanoma at the King Khaled Eye Specialist Hospital (KKESH), Riyadh, Saudi Arabia from June 1983 to July 2005 and met the inclusion criteria of the COMS. A medical record review of clinical history, imaging studies, surgical procedures and treatment outcome was performed. Forty patients (24 males and 16 females) with uveal melanoma (average age 50 years; range 24-77 years) were included in the study; 28 (70%) were of Saudi Arabian descent and the remaining 12 (30%) patients were from neighboring Arab countries. Decreased vision was the main presenting complaint of 29 (72.5%) patients; the duration of this symptom was 3 months or more in 27 (67.5%) patients. The apical height of the tumor was 10 mm or more in nine (22.5%) of the affected eyes and the largest basal dimension was more than 16 mm in nine (22.5%) of the affected eyes. The posterior border of the tumor was 1-2 mmfrom the optic disc in three (7.5%) affected eyes. Primary enucleation was performed for 33 (82.5%) eyes, episcleral radiation plaque therapy for six (15%) of the eyes and endo resection of the uveal melanoma in one (2.5%) eye. Adjunct external beam radiation therapy was performed in two (5%) orbits for extrascleral extension. The histopathological diagnosis was available for 34 (84%) eyes in which surgery had been performed (33 patients underwent primary enucleation and one patient underwent endo resection of the uveal melanoma); 24 (70.6%) eyes had spindle cell and the remaining 10 (29.4%) had epithelioid or mixed cell types. Evidence of extraocular tumor extension was found in three eyes. The average follow-up was 33.7 months with a median of 19 months (range 0.5 months to 10 years). Two (5

  13. Resistance, a Facet of Post-colonialism in Women Characters of Khaled Hosseini’s a Thousand Splendid Suns

    Directory of Open Access Journals (Sweden)

    Marzieh Gordan

    2013-05-01

    Full Text Available This article looks at female level of resistance though the viewpoint of post-colonialism and feminism based on Khaled Hosseini’s novel, Thousand Splendid Suns. The article concentrates on levels of resistance as a part of Afghan female's lifestyle against the gender oppression that are enforced on them through their lifestyle and culture, the objectives of their community and its standards.  The novel is selected for the discussion of this problem as it shows the conflicts experienced by Afghan females in regards to their positions and roles in their community and to find a unique identification as an individual. Findings on the conflicts of females and the level of resistance factors are seen in the novel though the analysis of the two primary characters in the novel Maryam and Laila, as the reflection of the truth of Afghan female's lifestyle. The framework for the article is designed by using Stephen Selmon’s, Edward Said’s and Benita Parry’s theories of level of resistance in the perspective of post-colonial and feminist literary discussion. This paper shows the observations created in regards to beliefs, gender discrimination and level of resistance within the area of Afghan female's lifestyle.

  14. How the Facebook Arabic Page “We Are All Khaled Said” Helped Promote the Egyptian Revolution

    Directory of Open Access Journals (Sweden)

    Kara Alaimo

    2015-09-01

    Full Text Available This study analyzes how the owner of the Facebook Arabic page “We Are All Khaled Said” both catalyzed and took advantage of opportunities in the Egyptian political climate in order to help promote the country’s 2011 revolution. Using a content analysis of posts on the Facebook page before and throughout the Egyptian revolution, the case study finds that the owner of the page, Wael Ghonim, served as a long-term trainer or coach, educating his online followers about the abuses of Egyptian President Hosni Mubarak’s regime and helping them gradually become more comfortable with political activism, so that when a triggering event—the Tunisian revolution—occurred, he was able to move his followers into the streets to protest. Two other particularly successful tactics were utilized by Ghonim: He capitalized on a powerful personal story—that of a young man brutally killed by the police—in order to elicit emotion and help others identify with the cause, and he used lofty rhetoric to convince his followers that their actions could actually make a difference. The case study disproves Gladwell’s (2010 claim that social media is a platform for shallow and networked interactions, finding both that the grievances and ideas shared on this page were remarkably substantive and that the movement was not a network but rather a hierarchy, led by Ghonim until his imprisonment. The study suggests that social media is a more powerful platform for promoting political change than previously appreciated and offers important lessons for political activists.

  15. Data critique and analytical opportunities for very large Facebook Pages: Lessons learned from exploring “We are all Khaled Said”

    Directory of Open Access Journals (Sweden)

    Bernhard Rieder

    2015-11-01

    Full Text Available This paper discusses the empirical, Application Programming Interface (API-based analysis of very large Facebook Pages. Looking in detail at the technical characteristics, conventions, and peculiarities of Facebook’s architecture and data interface, we argue that such technical fieldwork is essential to data-driven research, both as a crucial form of data critique and as a way to identify analytical opportunities. Using the “We are all Khaled Said” Facebook Page, which hosted the activities of nearly 1.9 million users during the Egyptian Revolution and beyond, as empirical example, we show how Facebook’s API raises important questions about data detail, completeness, consistency over time, and architectural complexity. We then outline an exploratory approach and a number of analytical techniques that take the API and its idiosyncrasies as a starting point for the concrete investigation of a large dataset. Our goal is to close the gap between Big Data research and research about Big Data by showing that the critical investigation of technicity is essential for empirical research and that attention to the particularities of empirical work can provide a deeper understanding of the various issues Big Data research is entangled with.

  16. المسكوكات البيزنطية والساسانية المتداولة في العــراق حتى أواخر عهد عبد الملك بن مروان Byzantine and Sassanian coins circulating in Iraq until the end of the reign of Abdul Malik bin Marwan

    Directory of Open Access Journals (Sweden)

    Ali Kadim Abbas Al-Shaik علي كاظم عباس الشيخ

    2012-12-01

    Full Text Available Money is regarded as an important document which cannot be neglected depended by archaeologists to identify archaeological sites as well as researchers and students in order to document historical events . Coins were invented by the people of kingdom of Laydia , the inhabitants of small Asia around 7th century B.C .Their kings have coined money on which they engraved first distinct from of money ( lion before bull . Then , it spread to the nearby areas related to the kingdom through trading relations . Coining was not only restricted to the trading exchange and treatment but it also had a religious and political from , hence , the figures , animals and pictures on the Greek , Roman , Ikhmini and even Sassani coins had a political or religious nature . In Arab Peninsula , Biziinti dinars were used in treatment in the past ( which hold king's portrait of Herocle alone or with his sons . In addition to Sassani dirham's ( which hold the Sassani king's portrait with fire stag and such coins were used in Syria , Egypt , and Iraq . The present study includes pictures of coins from Greece , Rome and Ikhmin. It also studies group of coins ( Bizinti dinars and Sassani dirham kept in Iraqi Museum which had been used pre and post – Islam . The researcher has studied inscriptions and figures held on the coins. When Islam appeared , such coins were decided to be used as a metal value. Finally , the stages of Arabization of these coins at the time of Islam have also been covered especially in Umayyad era during caliph Abdulmalik Bin Marwan ( 65 –86 – AH. to be purified from the foreign figures and use Quranic verses instead by means of pictures for the foreign money and their Arabization stages .

  17. Gender Discrimination in Orhan Pamuk's 'Snow' and Khaled Hosseini's 'A Thousand Splendid Suns'

    Directory of Open Access Journals (Sweden)

    Iis Sugianti

    2018-03-01

    Full Text Available Women's life without discrimination or violence is the freedom and entitlement of women's rights. The objective of the study is to achieve the idea. Dealing with it, the researcher applies feminism approach proposed by Damewood's theory of gender discrimination. Gender discrimination refers to the practice of granting or denying rights or privilege to a person based on his/her gender that is longstanding and acceptable to both genders. The novel `Snow` and `A Thousand Splendid Suns` focus on gender discrimination, violence, oppression, and struggle to fight against them. The researcher explores how gender discrimination, patriarchy culture and most of violence and oppression happened in family and country. The phenomenon of violence is not only a discrimination done by husbands who do gender discrimination in family, but also a fight done by a wife to fight against them, it depends on its case. In `Snow`, the women character faced many problems related to their headscarves. They are discriminated by their government and parents. Kadife is depicted as a brave woman. She tries to defend women‟s right in Kars to keep on using their headscarves. While in A `Thousand Splendid Suns`, the limitation of women`s activity happened. Women are banned to get education and they should stay at home. Mariam and Laila get oppression and violence by their husband. Their struggle is shown in the murder of their husband, Rasheed. The unstable practice of gender discrimination was continuously preserved by the culture, not religion. It was like a patriarchal culture that is one of clear examples of the women phenomena in the world and it can be in the form of prohibition and limitation of the role of women in the public area.

  18. Gender Discrimination in Orhan Pamuk's 'Snow' and Khaled Hosseini's 'A Thousand Splendid Suns'

    OpenAIRE

    Iis Sugianti

    2018-01-01

    Women's life without discrimination or violence is the freedom and entitlement of women's rights. The objective of the study is to achieve the idea. Dealing with it, the researcher applies feminism approach proposed by Damewood's theory of gender discrimination. Gender discrimination refers to the practice of granting or denying rights or privilege to a person based on his/her gender that is longstanding and acceptable to both genders. The novel `Snow` and `A Thousand Splendid Suns` focus on ...

  19. Data critique and analytical opportunities for very large Facebook Pages: Lessons learned from exploring "We are all Khaled Said"

    NARCIS (Netherlands)

    Rieder, B.; Abdulla, R.; Poell, T.; Woltering, R.; Zack, L.

    2015-01-01

    This paper discusses the empirical, Application Programming Interface (API)-based analysis of very large Facebook Pages. Looking in detail at the technical characteristics, conventions, and peculiarities of Facebook’s architecture and data interface, we argue that such technical fieldwork is

  20. Madeira üleujutus ja tuhk lükkasid reisifirma uppi / Khaled Ibrahim ; intervjueerinud Katre Pilvinski

    Index Scriptorium Estoniae

    Ibrahim, Khaled

    2010-01-01

    Reisifirma TopToursi juht ja omanik räägib, millest tekkisid firma raskused. Firma on alustanud investori otsimist, toimuvad läbirääkimised Šveitsi ja Itaalia rahvusvaheliste operaatorfirmadega, firmast on huvitatud ka üks Eesti erainvestor

  1. The Shift in Gender Roles in Amy Tan’s 'The Joy Luck Club' and Khaled Hosseini’s 'The Kite Runner'

    Directory of Open Access Journals (Sweden)

    Mujad Didien Afandi

    2018-03-01

    Full Text Available The unfair gender roles under patriarchal system are constructed to preserve gender inequality between men and women. Gender role practices extend gradually to maintain the male hegemony to make women powerless because female traditional gender roles (femininities create dependency to men. Men are assigned to masculinities equipped with power, whereas women are ascribed to femininities to set boundaries that limit their movement. Yet, the increase of female awareness of gender equality has changed this situation. Gender roles are gradually shifting from traditional to modern as the opportunities to receive education and job open widely to develop women's roles that enable them to give financial contribution to the family. This study was purposed to analyze the shift in gender roles in 'The Joy Luck Club' and 'The Kite Runner'. This study used qualitative design in which Chinese traditional gender roles were described using Confucian perspective, whereas Afghan traditional gender roles were exposed in Islamic perspective. Moreover, Karl Marx's conflict theory was used to analyze the shift in gender roles in both novels. The results of study found that the construction of traditional gender roles in both China and Afghanistan was influenced mostly by patriarchy which perceives men as more superior than women. However, the dynamic changes of gender roles, especially femininities, supported by the increase of female education and occupation provide women with more power to achieve development. Further studies are encouraged to analyze other gender roles which have not discussed in this study.

  2. The Shift in Gender Roles in Amy Tan’s 'The Joy Luck Club' and Khaled Hosseini’s 'The Kite Runner'

    OpenAIRE

    Mujad Didien Afandi

    2018-01-01

    The unfair gender roles under patriarchal system are constructed to preserve gender inequality between men and women. Gender role practices extend gradually to maintain the male hegemony to make women powerless because female traditional gender roles (femininities) create dependency to men. Men are assigned to masculinities equipped with power, whereas women are ascribed to femininities to set boundaries that limit their movement. Yet, the increase of female awareness of gender equality has c...

  3. Development of a web-based glaucoma registry at King Khaled Eye Specialist Hospital, Saudi Arabia: a cost-effective methodology.

    Science.gov (United States)

    Zaman, Babar; Khandekar, Rajiv; Al Shahwan, Sami; Song, Jonathan; Al Jadaan, Ibrahim; Al Jiasim, Leyla; Owaydha, Ohood; Asghar, Nasira; Hijazi, Amar; Edward, Deepak P

    2014-01-01

    In this brief communication, we present the steps used to establish a web-based congenital glaucoma registry at our institution. The contents of a case report form (CRF) were developed by a group of glaucoma subspecialists. Information Technology (IT) specialists used Lime Survey softwareTM to create an electronic CRF. A MY Structured Query Language (MySQL) server was used as a database with a virtual machine operating system. Two ophthalmologists and 2 IT specialists worked for 7 hours, and a biostatistician and a data registrar worked for 24 hours each to establish the electronic CRF. Using the CRF which was transferred to the Lime survey tool, and the MYSQL server application, data could be directly stored in spreadsheet programs that included Microsoft Excel, SPSS, and R-Language and queried in real-time. In a pilot test, clinical data from 80 patients with congenital glaucoma were entered into the registry and successful descriptive analysis and data entry validation was performed. A web-based disease registry was established in a short period of time in a cost-efficient manner using available resources and a team-based approach.

  4. A new look at low-energy nuclear reaction (LENR) research: a response to Shanahan

    OpenAIRE

    Marwan, J.; McKubre, M. C. H.; Tanzella, F. L.; Hagelstein, Peter L.; Miles, M. H.; Swartz, M. R.; Storms, Edmund; Iwamura, Y.; Mosier-Boss, P. A.; Forsley, L. P. G.

    2010-01-01

    In his criticisms of the review article on LENR by Krivit and Marwan, Shanahan has raised a number of issues in the areas of calorimetry, heat after death, elemental transmutation, energetic particle detection using CR-39, and the temporal correlation between heat and helium-4. These issues are addressed by the researchers who conducted the original work that was discussed in the Krivit-Marwan (K&M) review paper.

  5. 77 FR 25133 - Order Temporarily Denying Export Privileges

    Science.gov (United States)

    2012-04-27

    ... Housing Estate, The Gambia, West Africa; Abdullah Khaled Ramadan, Managing Director, Sam Air Corporation... Regulations in effect under the International Emergency Economic Powers Act (50 U.S.C. 1701, et seq.) (``IEEPA... Housing Estate, The Gambia, West Africa; Abdullah Khaled Ramadan, Managing Director, Sam Air Corporation...

  6. Pööre Lähis-Idas / Toomas Alatalu

    Index Scriptorium Estoniae

    Alatalu, Toomas, 1942-

    2007-01-01

    Palestiina rühmituste juhid Khaled Meshali ja Mahmud Abbasi jõudsid Mekas Saudi Araabia kuninga Abdullah' peetud läbirääkimistel kokkuleppele, millega lõpetatakse aastaid kestnud vastastikune vaenutsemine

  7. Top Toursi kohal rippus juba mõnda aega kahtluse vari / Gert D. Hankewitz ; Sirje Niitra

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2010-01-01

    Reisibüroo Top Tours omanik Ibrahim Khaled nimetab oma firma makseraskuste põhjuseks Euroopa lennunduses kaose tekitanud Islandi tuhapilve, turismifirmade liidul oli juba ammu kahtlus, et Top Tours ei ole jätkusuutlik

  8. В отношении Top Tours подозрения были и раньше / Герт Д. Ханкевич , Сирье Нийтра

    Index Scriptorium Estoniae

    Ханкевиц, Герт Д.

    2010-01-01

    Reisibüroo Top Tours omanik Ibrahim Khaled nimetab oma firma makseraskuste põhjuseks Euroopa lennunduses kaose tekitanud Islandi tuhapilve, turismifirmade liidul oli juba ammu kahtlus, et Top Tours ei ole jätkusuutlik

  9. The Translation Of Bound Morphemes In “Brokeback Mountain” By Annie Proulx Into “Gunung Brokeback” By Hetih Rusli

    OpenAIRE

    Dedy Rizki Damanik

    2009-01-01

    Skripsi ini berjudul “Rank Shift In ‘Kite Runner’ by Khaled Hosseini into ‘Kite Runner’ by Berliani M. Nugrahani : A Translation Analysis”, yang merupakan sebuah analisis tentang pergeseran pada tingkat Rank di hierarki linguistik yang terdiri atas morfem, kata, frase, klausa, dan kalimat yang terdapat pada novel “Kite Runner” oleh Khaled hosseini yang diterjemahkan ke dalam bahasa Indonesia “Kite Runner” oleh Berliani M. Nugrahani, dimana bahasa Inggris sebagai bahasa sumber dan bahasa Indon...

  10. Indian Academy of Sciences Conference Series | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Indian Academy of Sciences Conference Series. NORBERT MARWAN. Articles written in Indian Academy of Sciences Conference Series. Volume 1 Issue 1 December 2017 pp 51-60 Proceedings of the Conference on Perspectives in Nonlinear Dynamics - 2016. Inferring interdependencies from short time ...

  11. The educational environment of the undergraduate medical curriculum at Kuwait University

    OpenAIRE

    Karim J; Al-Halabi B; Marwan Y; Sadeq H; Dawas A; Al-Abdulrazzaq D

    2015-01-01

    Jumanah Karim,1 Becher Al-Halabi,2 Yousef Marwan,3 Hussain Sadeq,4 Ahmed Dawas,5 Dalia Al-Abdulrazzaq5 1Department of Pediatrics, Al-Amiri Hospital, Kuwait City, Kuwait; 2Department of Surgery, Mubarak Al-Kabeer Hospital, Kuwait City, Kuwait; 3Department of Orthopaedic Surgery, Al-Razi Orthopaedic Hospital, Kuwait City, Kuwait; 4Department of Pediatrics, Al-Adan Hospital, Kuwait City, Kuwait; 5Department of Pediatrics, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait Cit...

  12. Lecturing skills as predictors of tutoring skills in a problem-based medical curriculum

    OpenAIRE

    Kassab, Salah; Hassan,Nahla; Abu-Hijleh,Marwan; P Sequeira,Reginald

    2016-01-01

    Salah Eldin Kassab,1 Nahla Hassan,1 Marwan F Abu-Hijleh,2 Reginald P Sequeira3 1Department of Medical Education, Faculty of Medicine, Suez Canal University, Ismailia, Egypt; 2College of Medicine, Qatar University, Doha, Qatar; 3College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain Purpose: Recruitment of tutors to work in problem-based learning (PBL) programs is challenging, especially in that most of them are graduated from discipline-based programs. ...

  13. Pulmonary hypertension and vasculopathy in incontinentia pigmenti: a case report

    OpenAIRE

    Alshenqiti, Abduljabbar; Nashabat, Marwan; AlGhoraibi, Hissah; Tamimi, Omar; Alfadhel, Majid

    2017-01-01

    Abduljabbar Alshenqiti,1 Marwan Nashabat,1 Hissah AlGhoraibi,1 Omar Tamimi,2 Majid Alfadhel1 1Division of Genetics, Department of Pediatrics, King Abdullah International Medical Research Centre, King Saud bin Abdulaziz Uiversity for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia; 2Department of Cardiology, King Abdullah International Medical Research Centre, King Saud bin Abdulaziz University for Health Sciences, King Abdu...

  14. Reexamining Islam and Democracy Through the Wasatiyya Perspective

    Science.gov (United States)

    2014-12-01

    43 Marina Ottaway and Marwan Muasher, “Islamist Parties in Power: A Work in Progress,” Carnegie Endowment for International Peace, May 23, 2012...religions/muslims., and Todd M. Johnson and Brian J. Grim, ed., The World’s Religions in Figures: An Introduction to International Religious...also believe that the interpretations or understandings of man (i.e. Islamic jurisprudence (fiqh) and rulings of jurist/scholars (fatwa52)) are not

  15. Lifestyle modification in the management of the metabolic syndrome: achievements and challenges

    OpenAIRE

    Riccardo Dalle Grave; Simona Calugi; Elena Centis; et al

    2010-01-01

    Riccardo Dalle Grave1, Simona Calugi1, Elena Centis2, Rebecca Marzocchi2, Marwan El Ghoch1, Giulio Marchesini21Department of Eating & Weight Disorder, Villa Garda Hospital, Garda (VR), Italy; 2Unit of Metabolic Diseases & Clinical Dietetics, Alma Mater Studiorum – University of Bologna, Bologna, ItalyAbstract: Lifestyle modification based on behavior therapy is the most important and effective strategy to manage the metabolic syndrome. Modern lifestyle modification t...

  16. Proceedings of the Annual Midwest Research-to-Practice Conference in Adult, Continuing and Community Education (20th, Charleston, Illinois, September 26-28, 2001).

    Science.gov (United States)

    Hine, William C., Ed.

    The following 22 research papers are included in this proceedings: "Relationships between Scholarly Activities of Teaching and the Scholarly Activities of Research" (Ahmed Khaled Ahmed and James McElhinney); "Making the Invisible Visible: British Caribbean Immigrant Women & Their Learning Experiences in Institutions of Higher Learning" (Mary V.…

  17. A Page and Its Politics: Situating Kullinā Khālid Saʿīd in Egypt’s Ideological Landscape at the Time of Revolution

    NARCIS (Netherlands)

    Woltering, R.; Abdulla, R.; Poell, T.; Rieder, B.; Zack, L.

    2015-01-01

    In discussions concerning the importance of social media in the 25January revolution, a central role is given to the "Kullinā Khālid Saʿīd" [We’re all Khaled Said] Facebook page. Using an advanced data collection and extraction application called Netvizz, a research team consisting of Arabists and

  18. Fulltext PDF

    Indian Academy of Sciences (India)

    Frost, J. David. Gadre Vikram M. Gakkhar, R. P.. Galal, Khaled E. Gandhi, K. S.. Ganesh Anuradha. Gangashetty Suryakanth V. Gangopadhyay Soumya. Ganguly Swaroop. Garg Saurabh. Garg Ashish. Gaur Manoj. Gautam Kumar Dey. Gengaje Sachin R. George Joseph. Gerdts, M. Gettu Ravindra. Gevers Theo.

  19. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Abdolvahab Seif1 R Bagherzadeh2 Moein Goodarzi3 Khaled Azizi1. Department of Chemistry, Faculty of Science, University of Kurdistan, Sanandaj, Iran; Department of Engineering, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Golestan, Iran; Department of Chemistry, Institute for Advanced Studies in ...

  20. One-stage transanal Swenson procedure for rectosigmoid ...

    African Journals Online (AJOL)

    Ayman A. Al-Baghdady, Ehab A. El-Shafei and Khaled M. El-Asmar. Objective This .... Swenson for Hirschsprung's diseases Al-Baghdady et al. 105. Copyright r .... Hackman et al. [35] studied the risk .... Surg 2010; 45:1213–1220. 38 Stefano G ...

  1. Development of a Regional Habitat Classification Scheme for the ...

    African Journals Online (AJOL)

    A collaborative expedition between Khaled bin Sultan Living Oceans Foundation, Cambridge Coastal Research Unit and Seychelles Centre for Marine Research and Technology – Marine Parks Authority (SCMRT-MPA) was conducted to the southern Seychelles, western Indian Ocean, in January 2005. This resulted in a ...

  2. Clinical investigations in the diagnosis and treatment of the dry and wet eye

    NARCIS (Netherlands)

    Mansour, Khaled

    2007-01-01

    Een verstoorde traanhuishouding kan leiden tot diverse klachten. UMCG-onderzoeker Khaled Mansour deed onderzoek naar de diagnose en behandeling van twee aandoeningen: het Sjögren-syndroom en Epiphora, waarbij het oog respectievelijk te droog en te vochtig wordt. Mansour ontwikkelde een nieuwe

  3. African Journal of Biotechnology - Vol 11, No 77 (2012)

    African Journals Online (AJOL)

    Effects of calcium paste as a seed coat on growth, yield and enzymatic activities in NaCl stressed-pea plants · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD ... FULL TEXT DOWNLOAD FULL TEXT. Khaled M.A. Ramadan, AZ Abdel Azeiz, SE Hassanien, HF Eissa, 14166-14174 ...

  4. Book Review: Membongkar Logika Penafsir Agama

    Directory of Open Access Journals (Sweden)

    Mohammad Muslih

    2009-11-01

    Full Text Available Judul : Speaking in God’s Name: Islamic law,Authority and WomenPenulis : Khaled Abou el-FadlPenerbit : Oneworld Press, Oxford, 2001Tebal : 361 hlm.Edisi terj. : Atas Nama Tuhan, dari Fikih Otoriter keFikih OtoritatifPenerjemah : R. Cecep Lukman YasinPenerbit : Serambi, Jakarta 2004

  5. 2008. aasta menukaimad / Udo Uibo

    Index Scriptorium Estoniae

    Uibo, Udo, 1956-

    2009-01-01

    2008. aasta raamatumüügi tulemustest, mulluste menukamate kirjanike nimestikust, mis põhineb USA, Suurbritannia, Prantsusmaa, Saksamaa, Itaalia, Hollandi, Hiina, Hispaania ja Rootsi igakuistel ilukirjanduslike bestsellerite edetabelitel. Esikümnesse kuuluvad: Khaled Hossein, Stieg Larsson, Ken Follett, Stephenie Meyer, Muriel Barbery, Carlos Ruiz Zafón, Anna Gavalda, John Grisham, J. K. Rowling, Henning Mankell

  6. Ohlas tvorby Khaleda Hosseiniho v amerických a českých periodicích

    OpenAIRE

    Benešovský, Vít

    2016-01-01

    This bachelor's thesis deals with American and Czech reviews of three novels by Khaled Hosseini: The Kite Runner, A Thousand Splendid Suns and And the Mountains Echoed. The first chapter summarises the most important events of Afghanistan's modern history, the second chapter defines terms used in literary criticism and the three last chapters compare different reviews of each of the three novels.

  7. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Shatha Jameel Monaquel. Articles written in Pramana – Journal of Physics. Volume 80 Issue 4 April 2013 pp 677-684. Absolute parametric instability in a nonuniform plane plasma waveguide · Khaled Hamed El-Shorbagy Atef Ahmed El-Bendary Shatha Jameel Monaquel.

  8. Mitigation Strategies to Reduce Truck Crash Rates on Wyoming Highways

    Science.gov (United States)

    2017-05-04

    M Mahdi Rezapour Mashhadi (ORCID iD: 0000-0003-0774-737X); Promothes Saha, Ph.D., P.E. (ORCID iD: 0000-0003-3298-8327); Trenna Terrill (ORCID iD: 0000-0002-5239-6380); Khaled Ksaibati, Ph.D., P.E. (ORCID iD: 0000-0003-3532-6839) Wyoming has one of th...

  9. Jordaania ministrit võlus Liive õlitehas / Kadri Paas

    Index Scriptorium Estoniae

    Paas, Kadri, 1982-

    2010-01-01

    Jordaania energeetika ja maavarade minister Khaled Irani kohtus Eesti-visiidil Eesti peaminister Andrus Ansipi ja majandusminister Juhan Partsiga ning külastas Eesti Energia ehitatavat õlitehast. Jordaania valis Eesti Energia põlevkivil põhineva õlitööstuse ja energiatootmise arendajaks

  10. Collaborative Undergraduate HBCU Student Summer Prostate Cancer Training Program

    Science.gov (United States)

    2012-09-01

    Addiction: From Bench to Khaled Moussawi, MD/PhD Student Bedside June 14 Hepatic Steatosis in a Growing World: The Impact Dr. Kenneth Chavin...Treatment of Cocaine Addiction: From Bench to TBA Bedside June 13 Hepatic Steatosis in a Growing World: The Impact Dr. Kenneth Chavin, MD, PhD

  11. Ostrich: Journal of African Ornithology - Vol 88, No 1 (2017)

    African Journals Online (AJOL)

    DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Abdulmaula Hamza, Nicola Baccetti, Joe Sultana, Jaber Yahia, Marco Zantello, Adriano de Faveri, Nick Cutts, John Borg, Hichem Azafzaf, Pierre Defos du Rau, Esam Bourass, Khaled Etayeb, Michael Elliott, 53–58. http://dx.doi.org/10.2989/00306525.2016.1231139 ...

  12. Culture of Safety among Nurses in a Tertiary Teaching Hospital in ...

    African Journals Online (AJOL)

    Purpose: To assess the culture of safety among nurses in a tertiary teaching hospital in Saudi Arabia. Methods: A cross-sectional survey was conducted in King Khaled University Hospital in Riyadh, Saudi Arabia. A random sample of 492 nurses was included in the survey using a pre-validated instrument, Safety Attitudes ...

  13. adaptation et selection de varietes performantes de riz pluvi

    African Journals Online (AJOL)

    PROJET SOJA

    block obstacle and a rounded end rectangular obstacle. A study of the two dimensional flow around obstacles in terms of the Reynolds Reh number and the non dimensional ratios h/H (obstacle height to channel height) is considered to examine two models of obstacles, rectangular block obstacle and a. Khaled Aliane et al.

  14. Strategic Studies Quarterly. Volume 4, Number, Summer 2010

    Science.gov (United States)

    2010-01-01

    html. 68. Francis Fukuyama, "’Stateness’ First," Journal of Democracy 16, no. 1 (2005): 88. 69. Dobbins et al., Beginners Guide to Nation-Building, 255...USCENTCOM, "Operation Desert Shield/Desert Storm," 6. For a flowchart explain- ing these relationships, see Khaled bin Sultan, Desert Warrior (New

  15. Yet Unborn Realities

    DEFF Research Database (Denmark)

    Johannessen, Runa

    2016-01-01

    The scope of this paper is to inquire into a moment of friction between reality and possibility; the present and the future; the actual and the fictional, in a context pertaining to the Israel-Palestine conflict. The point of departure is an artwork by the Palestinian artist Khaled Jarrar. My enc...... encounter with his work evoked an aesthetic experience of hesitant uncertainty parallel to particular encounters with a mechanism invoking such uncertainties in real life, namely the passport control......The scope of this paper is to inquire into a moment of friction between reality and possibility; the present and the future; the actual and the fictional, in a context pertaining to the Israel-Palestine conflict. The point of departure is an artwork by the Palestinian artist Khaled Jarrar. My...

  16. Развод чистой воды / Ярослав Тавгень ; комментировали Свен Лыокене, Татьяна Архипова, Майя Гончаренко

    Index Scriptorium Estoniae

    Тавгень, Ярослав

    2011-01-01

    Reisibüroo Estour on 18. juunil enda pankroti välja kuulutanud, kuid veel 17. juunil alustati uue reklaamikampaaniaga, mille käigus pakuti reise Dominikaani Vabariiki. Reisid pidid toimuma koostöös Poola reisibürooga Alba Tour, mida juhib samuti pankrotistunud TopTours OÜ endine juht Ibragim Khaled. Konkurendid arvavad, et pankrotistuda võib ka GoAdventure

  17. Kohastumus eluks vee ääres / Laura Kuusk

    Index Scriptorium Estoniae

    Kuusk, Laura, 1982-

    2007-01-01

    4. "Ars Baltica" fototriennaal Kumu Kunstimuuseumis kuni 30. IX. Tellervo Kalleineni ja Oliver Kochta-Kalleineni, Alexander Vaindorfi, Coloneli (Thierry Geoffroy) ja Khaled D. Ramadani, Kaspars Goba, Tanja Nellemann Poulseni, Katrin Teesi, Anu Pennaneni, Petra Baueri, Talleiv Taro Manumi (sünd. 1968 Jaapanis, elab Norras), Olga Tshernõsheva, Kristina Inciuraite, Julita Wojciki, Sven Johne, Anna Baumgarti, Arturas Valiauga ja duo J&K (Janne Schäfer, Kristine Agergaard) töödest

  18. Science and Technology for Communication and Persuasion Abroad: Gap Analysis and Survey

    Science.gov (United States)

    2012-03-01

    technology are heavily influenced by studying technology use in the West—which, some argue, biases the field toward individualist rather than collectivist ...serious games, particularly for non-Western cultures , and to develop new technologies to that end. Such investment should include immersive virtual...environments, which favor different strategies of influence than text-based environments.27 Rilla Khaled, " Culturally -Relevant Persuasive Technology

  19. Science and Technology for Communication and Persuasion Aboard: Gap Analysis and Survey. Revision

    Science.gov (United States)

    2012-03-01

    in the West—which, some argue, biases the field toward individualist rather than collectivist motives for action. Although the U.S. government has...campaigns. It might be worthwhile to invest in research on the persuasiveness of so- called serious games, particularly for non-Western cultures , and to...text-based environments. ’ Rilla Khaled, " Culturally -Relevant Persuasive Technology" (Dissertation, Victoria University of Wellington, 2008), 11

  20. Explaining Sectarian Violence in the Middle East: A Comparative Study of Bahrain and Yemen

    Science.gov (United States)

    2016-06-01

    Sectarian Politics in the Persian Gulf, ed. Lawrence G. Potter (New York: Oxford University Press, 2014), 144. 9 Khaled Fattah, “Yemen: Sectarianism...and the Politics of Regime Survival,” in Sectarian Politics in the Persian Gulf, ed. Lawrence G. Potter (New York: Oxford University Press, 2014), 209...figures capable of instrumentalization (President Ali Abdullah Saleh in Yemen and King Hamad al-Khalifa in Bahrain). Both nations have had, and

  1. Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics

    OpenAIRE

    Ahmed OA; Hosny KM; Al-Sawahli MM; Fahmy UA

    2015-01-01

    Osama AA Ahmed,1,2 Khaled M Hosny,1,3 Majid M Al-Sawahli,1,4 Usama A Fahmy11Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Minia University, Minia, Egypt; 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt; 4Holding Company for Biological Products & Vaccines (VACSERA), Cairo...

  2. Virtual reality simulator for vitreoretinal surgery using integrated OCT data

    OpenAIRE

    Kozak, Igor; Banerjee,Pat; Luo,Jia; Luciano,Cristian

    2014-01-01

    Igor Kozak,1 Pat Banerjee,2 Jia Luo,2 Cristian Luciano21King Khaled Eye Specialist Hospital, Vitreoretinal Division, Riyadh, Kingdom of Saudi Arabia; 2College of Engineering, University of Illinois at Chicago, Chicago, IL, USAAbstract: Operative practice using surgical simulators has become a part of training in many surgical specialties, including ophthalmology. We introduce a virtual reality retina surgery simulator capable of integrating optical coherence tomography (OCT) scans from real p...

  3. Suicidal and self-injurious behavior among patients with alcohol and drug abuse

    OpenAIRE

    Al-Sharqi, Abdullah Mohammed; Sherra, Khaled Saad; Al-Habeeb, Abdulhameed Abdullah; Qureshi, Naseem Akhtar

    2012-01-01

    Abdullah Mohammed Al-Sharqi,1 Khaled Saad Sherra,2 Abdulhameed Abdullah Al-Habeeb,3 Naseem Akhtar Qureshi3,41Private Clinic, Riyadh, Saudi Arabia; 2Psychiatric Department, Faculty of Medicine, Mansoura University, Egypt; 3General Administration for Mental Health and Social Services, 4General Directorate of Research and Studies, Ministry of Health, Riyadh, Saudi ArabiaBackground: Self-injurious behavior, a major public health problem globally, is linked with alcohol and drug abuse. This cross-...

  4. Al Qaeda in the Arabian Peninsula (AQAP): An Al Qaeda Affiliate Case Study

    Science.gov (United States)

    2017-10-01

    Villarosa, Al-Qaeda in Yemen, Carnegie Endowment, July 7, 2009, http://carnegieendowment.org/2009/07/07/Al-Qaeda-in-yemen- event-1372. 53 Brian Whitaker...73 Khaled Fattah, “Yemen’s Insecurity Dilemma,” Yemen Times, February 11, 2014, http:// carnegie -mec.org/2014/02...Johnsen, and Shari Villarosa, “Al-Qaeda in Yemen.” Carnegie Endowment. July 7, 2009. http://carnegieendowment.org/2009/07/07/Al-Qaeda-in- yemen-event

  5. Social class conflict presented in “the kite runner” novel based on marxism theory

    OpenAIRE

    Yohanes Eko Rubiyanto

    2017-01-01

    Abstract The writer conducts the research related to class conflict which is presented in Khaled Hosseini’s “The Kite Runner” novel. This qualitative research is written to analyze the conflicts that happen in Afghan society which is mainly caused by difference of social class. The research is conducted by using library research. The method used in this research is descriptive qualitative method as the data are described in the form of sentences. The steps of collecting the data in this re...

  6. Virtual reality simulator for vitreoretinal surgery using integrated OCT data

    Directory of Open Access Journals (Sweden)

    Kozak I

    2014-03-01

    Full Text Available Igor Kozak,1 Pat Banerjee,2 Jia Luo,2 Cristian Luciano21King Khaled Eye Specialist Hospital, Vitreoretinal Division, Riyadh, Kingdom of Saudi Arabia; 2College of Engineering, University of Illinois at Chicago, Chicago, IL, USAAbstract: Operative practice using surgical simulators has become a part of training in many surgical specialties, including ophthalmology. We introduce a virtual reality retina surgery simulator capable of integrating optical coherence tomography (OCT scans from real patients for practicing vitreoretinal surgery using different pathologic scenarios.Keywords: optical coherence tomography

  7. Ludic interfaces. Driver and product of gamification

    Directory of Open Access Journals (Sweden)

    Mathias Fuchs

    2012-05-01

    Full Text Available The recent success of non-standard and playful interface devices like Wii Remote, Move, and Kinect is an indicator of a process that demonstrates that ludic interfaces might be the core driver for a transformation in the sector of video games cultures and beyond. Yet, ludic interfaces are drivers—as well as driven by social developments known as the ludification (Raessens, 2006; Fuchs & Strouhal, 2008, or the gamification of society (Schell, 2010; Bogost, 2010; Ionifides, 2011; Deterding, Khaled, Nacke, & Dixon, 2011.

  8. MENJADI WAKIL TUHAN (Memahami Pemikiran Khalid M. Abou El Fadl tentang Konsep Otoritas Penafsir Pesan Tuhan

    Directory of Open Access Journals (Sweden)

    Kadi -

    2013-08-01

    Full Text Available Tulisan ini mencabar konsep otoritas, terutama dalam bidanghukum Islam, menurut Khaled M. Abou El Fadl. Sistematikayang digunakan olehnya dalam menuangkan gagasannyatersebut adalah pertama-tama menjelaskan latar belakangmunculnya krisis otoritas. Kemudian dia menjelaskan konsepotoritas secara umum dengan mengadopsi pemikiranFriedman yang membedakan otoritas persuasif dari otoritasyang bersifat koersif. Melalui pembahasan yang sangatsistematis-analitis, kemudian dia menawarkan konsepotoritas dalam Islam yang harus memenuhi lima kriteria yangmenurutnya harus dipenuhi oleh seorang pemegang otoritas,yakni para ahli hukum, agar produk hukum yangdihasilkannya mendapat legitimasi kuat dan berlakuuniversal. Kelima prasyarat tersebut adalah kejujuran(honesty, kesungguhan (diligence, menyeluruh(comprehensiveness, rasionalitas (reasonableness, danpengendalian diri (self restraint. Dengan konsep otoritas yangdia tawarkan, dia ingin menggugat kemapanan ilmu dantradisi hukum Islam yang menurutnya telah “menempati”dan “melampaui” otoritas Tuhan. Orang-orang yangmendeklarasikan dirinya sebagai para wakil Tuhandipandang olehnya sebagai sikap otoritarianisme.

  9. SESAME on track for commissioning

    CERN Multimedia

    CERN Bulletin

    2012-01-01

    On Thursday 16 May, ambassadors, official representatives and delegates from countries in the Middle East arrived at CERN to participate in an event supporting SESAME, which included the signing of a new agreement between CERN and SESAME. The agreement adds to growing multi-national support for SESAME – vital ingredients for the completion of the project.   SESAME Director Khaled Toukan and CERN Director General Rolf Heuer signing the joint agreement. They are accompanied by (left to right): Seyed Mahmoud Reza Aghamiri, co-Vice President of the SESAME Council; Chris Llewellyn Smith, former CERN Director General and current SESAME Council President; and Mohamed Tarek Hussein, co-Vice President of the SESAME Council. It reads like a page out of CERN’s own history: a scientific collaboration, founded under the auspices of UNESCO, dedicated to peaceful physics research. But instead of post-war Europe, SESAME is being built in Jordan. The project brings together partners from ...

  10. Bruxism Associated with Anoxic Encephalopathy: Successful Treatment with Baclofen

    Directory of Open Access Journals (Sweden)

    A. Bruce Janati

    2013-01-01

    Full Text Available Introduction. Bruxism is a movement disorder characterized by grinding and clenching of the teeth. Etiology of bruxism can be divided into three groups: psychosocial factors, peripheral factors, and pathophysiological factors. Methods. The clinical investigation was conducted at King Khaled Hospital in Hail, Saudi Arabia, in 2012. Results. A 16-year-old Saudi female was brought to the hospital in a comatose state and with generalized convulsive seizures secondary to acute anoxic encephalopathy. In the third week of hospitalization, while still in a state of akinetic mutism, she developed incessant bruxism which responded favorably to a GABA receptor agonist (baclofen. Conclusion. Our data support the hypothesis that bruxism emanates from imbalance or dysregulation of the neurotransmitter system. Larger scale studies will be needed to confirm this hypothesis.

  11. PRÉVALENCE DE LISTERIA MONOCYTOGENES DANS LE LAIT CRU DE VACHE AU LIBAN NORD

    Directory of Open Access Journals (Sweden)

    Imad al Kassaa

    2016-06-01

    Full Text Available Al Kassaa Imad, Khaled el Omari, Marwa Saati, Bachar Ismail and Monzer Hamze. 2016. Prevalence of Listeria monocytogenes in raw cow milk in north Lebanon. Lebanese Science Journal, 17(1: 39-45. Listeriosis, although a zoonosis, is an invasive disease that can affect newborns, pregnant women and immunocompromised adults. Clinical manifestations can be expressed by febrile gastroenteritis, invasive forms including severe sepsis, meningitis, rhombencephalitis, prenatal infections and abortions. Species of Listeria bacteria are ubiquitous and adaptable to the environment in animal and plant foods. This study aimed to determine the prevalence of Listeria monocytogenes in 100 samples of fresh cow milk collected from different areas of North Lebanon. Listeria monocytogenes was detected by using the Grand VIDAS technique (Biomérieux France. The results obtained revealed the absence of Listeria monocytogenes in all analyzed samples.

  12. Clinical epidemiology of premenstrual disorder: informing optimized patient outcomes

    Directory of Open Access Journals (Sweden)

    Robinson LLL

    2015-09-01

    Full Text Available Lynne LL Robinson,1 Khaled MK Ismail1,21Department of Obstetrics and Gynaecology, Birmingham Women’s Hospital, Birmingham, UK; 2Birmingham Centre for Women’s and Children’s Health, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKAbstract: Premenstrual disorders encompass a spectrum that ranges from mild cyclical psychological and somatic symptoms to the rarer but much-more-severe premenstrual dysphoric disorder. This condition is serious and the etiology is unclear, but possible causes include genetic factors, hormonal fluctuations, and neurotransmitter dysfunctions. Differentiation from other affective disorders can be difficult but is key to providing appropriate management. This comprehensive review will discuss the most-recent classification of premenstrual disorders, etiology, diagnosis, and potential current management strategies.Keywords: premenstrual dysphoric disorder, progesterone, oestrogen, oophrectomy, GNRH analogues

  13. Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets

    Directory of Open Access Journals (Sweden)

    Alicia Galindo-Ferreiro

    2017-12-01

    Full Text Available Purpose: We report 6 patients who received a hydroxyapatite (HA orbital implant in the socket and developed chronic orbital inflammation unresponsive to conventional medical therapy. Case Reports: We assisted 6 cases (4 males, 2 females who received an HA orbital implant in the socket between 2015 and 2016 at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, and developed chronic orbital inflammation with chronic discharge, redness, and pain (onset from weeks to over 2 decades after surgery. Computed tomography evaluation indicated inflammation in the orbital tissues, and histological examination showed a foreign body granulomatous reaction mainly localized around and blanching the HA implant. The condition was unresponsive to usual medical treatment and was resolved immediately after implant removal. Conclusions: Chronic inflammation can occur decades after placement of an HA implant in the orbit and can be successfully treated with implant removal.

  14. Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population.

    Science.gov (United States)

    Gruener, Anna M; Chang, Jessica R; Bosley, Thomas M; Al-Sadah, Zakeya M; Kum, Clarissa; McCulley, Timothy J

    2017-12-01

    To evaluate the relative frequencies of arteritic and nonarteritic anterior ischemic optic neuropathy (AION) in an Arab population and to compare and contrast these findings with known epidemiological data from Caucasian populations. A retrospective review of the medical records of all patients diagnosed with AION at the King Khaled Eye Specialist Hospital (KKESH) in Riyadh, Saudi Arabia, between 1997 and 2012. Of 171 patients with AION, 4 had biopsy-proven giant-cell arteritis (GCA). The relative frequencies of arteritic anterior ischemic optic neuropathy (AAION) and nonarteritic anterior ischemic optic neuropathy (NAION) in this Arab cohort were 2.3% and 97.7%, respectively. The relative frequencies of arteritic anterior ischemic optic neuropathy and nonarteritic anterior ischemic optic neuropathy differ between Arab and North American clinic-based populations, with giant-cell arteritis-related ischemia being much less frequent in Saudi Arabia.

  15. EU Commissioner Carlos Moedas visits SESAME

    CERN Multimedia

    CERN Bulletin

    2015-01-01

    The European Commissioner for research, science and innovation, Carlos Moedas, visited the SESAME laboratory in Jordan on Monday 13 April. When it begins operation in 2016, SESAME, a synchrotron light source, will be the Middle East’s first major international science centre, carrying out experiments ranging from the physical sciences to environmental science and archaeology.   CERN Director-General Rolf Heuer (left) and European Commissioner Carlos Moedas with the model SESAME magnet. © European Union, 2015.   Commissioner Moedas was accompanied by a European Commission delegation led by Robert-Jan Smits, Director-General of DG Research and Innovation, as well as Rolf Heuer, CERN Director-General, Jean-Pierre Koutchouk, coordinator of the CERN-EC Support for SESAME Magnets (CESSAMag) project and Princess Sumaya bint El Hassan of Jordan, a leading advocate of science in the region. They toured the SESAME facility together with SESAME Director, Khaled Tou...

  16. Social class conflict presented in “the kite runner” novel based on marxism theory

    Directory of Open Access Journals (Sweden)

    Yohanes Eko Rubiyanto

    2017-04-01

    The writer conducts the research related to class conflict which is presented in Khaled Hosseini’s “The Kite Runner” novel. This qualitative research is written to analyze the conflicts that happen in Afghan society which is mainly caused by difference of social class. The research is conducted by using library research. The method used in this research is descriptive qualitative method as the data are described in the form of sentences. The steps of collecting the data in this research are reading both the novel and the supporting theories related, analyzing, organizing and displaying the data to allow conclusions to be drawn. The results show that the society in the twentieth is fundamentally separated by two large groups namely Pashtun and Hazara. They are inhabit Afghanistan as told in The Kite Runner. The Pashtuns act as the dominant upper class and the Hazaras fill the society of the lower class which fits the theory of Marxism.

  17. Nystagmus in Laurence-Moon-Biedl Syndrome

    Directory of Open Access Journals (Sweden)

    A. Bruce Janati

    2015-01-01

    Full Text Available Introduction. Laurence-Moon-Biedl (LMB syndrome is a rare autosomal-recessive ciliopathy with manifold symptomatology. The cardinal clinical features include retinitis pigmentosa, obesity, intellectual delay, polydactyly/syndactyly, and hypogenitalism. In this paper, the authors report on three siblings with Laurence-Moon-Biedl syndrome associated with a probable pseudocycloid form of congenital nystagmus. Methods. This was a case study conducted at King Khaled Hospital. Results. The authors assert that the nystagmus in Laurence-Moon-Biedl syndrome is essentially similar to idiopathic motor-defect nystagmus and the nystagmus seen in optic nerve hypoplasia, ocular albinism, and bilateral opacities of the ocular media. Conclusion. The data support the previous hypothesis that there is a common brain stem motor abnormality in sensory-defect and motor-defect nystagmus.

  18. The use of a virtual reality surgical simulator for cataract surgical skill assessment with 6 months of intervening operating room experience

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    Sikder S

    2015-01-01

    Full Text Available Shameema Sikder,1 Jia Luo,2 P Pat Banerjee,2 Cristian Luciano,2 Patrick Kania,2 Jonathan C Song,1 Eman S Kahtani,3 Deepak P Edward,1,3 Abdul-Elah Al Towerki3 1Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA; 2College of Engineering, University of Illinois at Chicago, Chicago, IL, USA; 3King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Purpose: To evaluate a haptic-based simulator, MicroVisTouch™, as an assessment tool for capsulorhexis performance in cataract surgery. The study is a prospective, unmasked, nonrandomized dual academic institution study conducted at the Wilmer Eye Institute at Johns Hopkins Medical Center (Baltimore, MD, USA and King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia.Methods: This prospective study evaluated capsulorhexis simulator performance in 78 ophthalmology residents in the US and Saudi Arabia in the first round of testing and 40 residents in a second round for follow-up.Results: Four variables (circularity, accuracy, fluency, and overall were tested by the simulator and graded on a 0–100 scale. Circularity (42%, accuracy (55%, and fluency (3% were compiled to give an overall score. Capsulorhexis performance was retested in the original cohort 6 months after baseline assessment. Average scores in all measured metrics demonstrated statistically significant improvement (except for circularity, which trended toward improvement after baseline assessment. A reduction in standard deviation and improvement in process capability indices over the 6-month period was also observed.Conclusion: An interval objective improvement in capsulorhexis skill on a haptic-enabled cataract surgery simulator was associated with intervening operating room experience. Further work investigating the role of formalized simulator training programs requiring independent simulator use must be studied to determine its usefulness as an evaluation tool. Keywords: medical education, computer simulation

  19. A practical study for Treatment and Conservation a group of Silver Coins from Dhamar Regional Museum, Dhamar, Yemen.

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    Mohamed M. Megahed

    2014-04-01

    Full Text Available A big group of silver coins{35 coins} was discovered in Banawa excavation , Dhamar , season 2002, and now it is situated in Dhamar Regional Museum ,Yemen. They were covered with a thin grey and black corrosion layers that disfigured them and hid their figures and inscriptions , also Some coins miss parts and others lost their circular.The aims of this work are identified the metallic composition of the coins , investigate the nature of corrosion grown during the long-term burial and identify its products that will help us to understand the corrosive factors and the degradation mechanisms , cleaning the group of coins from the superficial dirt and the corrosion products in order to discover as much as possible the surface topography, and to reveal the surfaces details , finally to establish them against further deterioration .To achieve that samples from the coins were examined by Metallographic Microscope {ME} , Scanning Electron Microscope {SEM}, the corrosion products were analyzed by X-ray diffraction{XRD} , and X-ray fluorescence { XRF} was used to determine the coins metallic constituents. Chemical cleaning was chosen for treating the coins and they were isolated to preserve them against further attack. After treatment and conservation, the coins figures and inscriptions that could be identified showed that this group of coins dates back to Umayyad period , exactly the reign of caliph Abd al-Malik ibn Marwan{ 65- 86 A.H}{685-705A.D} and his descendants till 106 A.H. 

  20. Psychology and modern life challenges: the 2nd Middle East and North Africa Regional Conference of Psychology, Amman, Jordan, 2007.

    Science.gov (United States)

    Knowles, Michael; Sabourin, Michel

    2008-04-01

    The Second Middle East and North Africa Regional Conference of Psychology was held in Amman from 27 April - 1 May 2007 under the Royal Patronage of Her Majesty Queen Rania Al-Abdullah and the auspices of the International Union of Psychological Science, the International Association of Applied Psychology, and the International Association of Cross-Cultural Psychology. It was hosted by the Jordanian Psychological Association whose President was Dr. Asaad Zuby. The President of the Conference and the Local Organizing Committee was Dr. Adnan Farah, the Chair of the Scientific Program Committee was Dr. Mohammad Rimawi, and the Chair of the Regional Advisory Committee was Dr. Marwan Dwairy. The Conference succeeded in attracting participants from 28 countries, including 15 from the Middle East and North Africa region. The Scientific Program explored ways and means to promote the role of psychology in meeting life challenges at regional and international levels. The Conference concluded with the signing of a formal Declaration which called upon governments, academic and professional institutions and organizations, non-governmental organization and other civil society groups, and the United Nations, to work together and to make every possible effort individually and collectively to achieve these goals.

  1. Effect of age and sex on warfarin dosing

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    Khoury G

    2014-07-01

    Full Text Available Ghada Khoury,1 Marwan Sheikh-Taha2 1School of Pharmacy, 2Department of Pharmacy Practice, Lebanese American University, Byblos, Lebanon Objective: We examined the potential effect of sex and age on warfarin dosing in ambulatory adult patients. Methods: We conducted a retrospective chart review of patients attending an anticoagulation clinic. We included patients anticoagulated with warfarin for atrial fibrillation or venous thromboembolism who had a therapeutic international normalized ratio of 2–3 for 2 consecutive months. We excluded patients who had been on any drug that is known to have a major interaction with warfarin, smokers, and heavy alcohol consumers. Out of 340 screened medical records, 96 met the predetermined inclusion criteria. The primary outcome assessed was warfarin total weekly dose (TWD. Results: There was a statistically significant difference in the TWD among the ages (P<0.01; older patients required lower doses. However there was no statistically significant difference in the TWD between sexes (P=0.281. Conclusion: Age was found to have a significant effect on warfarin dosing. Even though women did require a lower TWD than men, this observation was not statistically significant. Keywords: warfarin, INR, anticoagulation, vitamin K antagonists, age

  2. Pulmonary hypertension and vasculopathy in incontinentia pigmenti: a case report

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    Alshenqiti A

    2017-05-01

    Full Text Available Abduljabbar Alshenqiti,1 Marwan Nashabat,1 Hissah AlGhoraibi,1 Omar Tamimi,2 Majid Alfadhel1 1Division of Genetics, Department of Pediatrics, King Abdullah International Medical Research Centre, King Saud bin Abdulaziz Uiversity for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs (NGHA, Riyadh, Saudi Arabia; 2Department of Cardiology, King Abdullah International Medical Research Centre, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA, Riyadh, Saudi Arabia Abstract: Incontinentia pigmenti (IP; Bloch–Sulzberger syndrome is a rare, genetic syndrome inherited as an X-linked dominant trait. It primarily affects female infants and is lethal in the majority of males during fetal life. The clinical findings include skin lesions, developmental defects, and defects of the eyes, teeth, skeletal system, and central nervous system. Cardiovascular complications of this disease in general, and pulmonary hypertension in particular, are extremely rare. This report describes the case of a 3-year-old girl with IP complicated by pulmonary arterial hypertension. Extensive cardiology workup done to the patient indicates underlying vasculopathy. This report sheds light on the relationship between IP and pulmonary hypertension, reviews the previously reported cases, and compares them with the reported case. Keywords: incontinentia pigmenti, IKBKG, pulmonary hypertension, vasculopathy, Bloch–Sulzberger syndrome, lines of Blaschko, hyperpigmentation

  3. Lifestyle modification in the management of the metabolic syndrome: achievements and challenges

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    Marchesini G

    2010-11-01

    Full Text Available Riccardo Dalle Grave1, Simona Calugi1, Elena Centis2, Rebecca Marzocchi2, Marwan El Ghoch1, Giulio Marchesini21Department of Eating & Weight Disorder, Villa Garda Hospital, Garda (VR, Italy; 2Unit of Metabolic Diseases & Clinical Dietetics, Alma Mater Studiorum – University of Bologna, Bologna, ItalyAbstract: Lifestyle modification based on behavior therapy is the most important and effective strategy to manage the metabolic syndrome. Modern lifestyle modification therapy combines specific recommendations on diet and exercise with behavioral and cognitive strategies. The intervention may be delivered face-to-face or in groups, or in groups combined with individual sessions. The main challenge of treatment is helping patients maintain healthy behavior changes in the long term. In the last few years, several strategies have been evaluated to improve the long-term effect of lifestyle modification. Promising results have been achieved by combining lifestyle modification with pharmacotherapy, using meals replacement, setting higher physical activity goals, and long-term care. The key role of cognitive processes in the success/failure of weight loss and maintenance suggests that new cognitive procedures and strategies should be included in the traditional lifestyle modification interventions, in order to help patients build a mind-set favoring long-term lifestyle changes. These new strategies raise optimistic expectations for an effective treatment of metabolic syndrome with lifestyle modifications, provided public health programs to change the environment where patients live support them.Keywords: metabolic syndrome, obesity, lifestyle modification, cognitive behavior therapy

  4. A multi-proxy reconstruction of Holocene climate change from Blessberg Cave, Germany

    Science.gov (United States)

    Breitenbach, Sebastian F. M.; Plessen, Birgit; Wenz, Sarah; Leonhardt, Jens; Tjallingii, Rik; Scholz, Denis; Jochum, Klaus Peter; Marwan, Norbert

    2016-04-01

    Although Holocene climate dynamics were relatively stable compared to glacial conditions, climatic changes had significant impact on ecosystems and human society on various timescales (Mayewski et al. 2004, Donges et al. 2015, Tan et al. 2015). Precious few high-resolution records on Holocene temperature and precipitation conditions in Central Europe are available (e.g., von Grafenstein et al. 1999, Fohlmeister et al. 2012). Here we present a speleothem-based reconstruction of past climate dynamics from Blessberg Cave, Thuringia, central Germany. Three calcitic stalagmites were recovered when the cave was discovered during tunneling operations in 2008. Samples BB-1, -2 and -3 were precisely dated by the 230Th/U-method, with errors between 10 and 160 years (2σ). The combined record covers large parts of the Holocene (10 - 0.4 ka BP). δ13C and δ18O were analysed at 100 μm resolution. To gain additional insights in infiltration conditions, Sr/Ca and S/Ca were measured on BB-1 and BB-3 using an Röntgenanalytik Eagle XXL μXRF scanner. Differences to other central European records (e.g., von Grafenstein et al. 1999, Fohlmeister et al. 2012) suggest complex interaction between multiple factors influencing speleothem δ18O in Blessberg Cave. Furthermore, no clear influence of the North Atlantic Oscillation on our proxies is found. However, a link across the N Atlantic realm is indicated by a centennial-scale correlation between Blessberg δ18O values and minerogenic input into lake SS1220 in Greenland over the last 5 ka (Olsen et al. 2012). In addition, recurrence analysis indicates an imprint of Atlantic Bond events on Blessberg δ18O values (Marwan et al. 2014), corroborating the suggested link with high northern latitudes. Larger runoff into the Greenland lake seems to be associated with lower δ18O, higher δ13C and S/Ca ratios, as well as lower Sr/Ca ratios in Blessberg Cave speleothems. This might be linked to lower local temperature and/or changes in

  5. Medical and surgical ward rounds in teaching hospitals of Kuwait University: students’ perceptions

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    AlMutar S

    2013-09-01

    Full Text Available Sara AlMutar,1 Lulwa AlTourah,1 Hussain Sadeq,2 Jumanah Karim,2 Yousef Marwan3 1Department of Medicine, 2Department of Pediatrics, Mubarak Al-Kabeer Hospital, 3Department of Orthopedic Surgery, Al-Razi Orthopedic Hospital, Kuwait City, Kuwait Background: Teaching sessions for medical students during ward rounds are an essential component of bedside teaching, providing students with the opportunity to regard patients as actual people, and to observe their physical conditions directly, allowing a better understanding of illnesses to be developed. We aim to explore medical students’ perceptions regarding medical and surgical ward rounds within the Faculty of Medicine at Kuwait University, and to evaluate whether this teaching activity is meeting the expectation of learners. Methods: A pretested questionnaire was used to collect data from 141 medical students during the 2012–2013 academic year. They were asked to provide their current and expected ratings about competencies that were supposed to be gained during ward rounds, on a scale from 1 (lowest to 5 (highest. Mean scores were calculated, and the Student t-test was used to compare results. P < 0.05 was the cut-off level for significance. Results: Only 17 students (12.1% declined to participate in the study. The students' current competency scores (for competencies taught within both disciplines – medical and surgical were significantly lower than the scores indicating students’ expectations (P < 0.001. The best-taught competency was bedside examination, in both medical (mean: 3.45 and surgical (mean: 3.05 ward rounds. However, medical ward rounds were better than surgical rounds in covering some competencies, especially the teaching of professional attitude and approach towards patients (P < 0.001. Conclusion: Both medical and surgical ward rounds were deficient in meeting the students’ expectations. Medical educators should utilize the available literature to improve the bedside

  6. Lecturing skills as predictors of tutoring skills in a problem-based medical curriculum

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    Kassab SE

    2016-01-01

    Full Text Available Salah Eldin Kassab,1 Nahla Hassan,1 Marwan F Abu-Hijleh,2 Reginald P Sequeira3 1Department of Medical Education, Faculty of Medicine, Suez Canal University, Ismailia, Egypt; 2College of Medicine, Qatar University, Doha, Qatar; 3College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain Purpose: Recruitment of tutors to work in problem-based learning (PBL programs is challenging, especially in that most of them are graduated from discipline-based programs. Therefore, this study aims at examining whether lecturing skills of faculty could predict their PBL tutoring skills. Methods: This study included evaluation of faculty (n=69 who participated in both tutoring and lecturing within particular PBL units at the College of Medicine and Medical Sciences (CMMS, Arabian Gulf University, Bahrain. Each faculty was evaluated by medical students (n=45±8 for lecturing and 8±2 for PBL tutoring using structured evaluation forms based on a Likert-type scale (poor to excellent. The prediction of tutoring skills using lecturing skills was statistically analyzed using stepwise linear regression. Results: Among the parameters used to judge lecturing skills, the most important predictor for tutoring skills was subject matter mastery in the lecture by explaining difficult concepts and responding effectively to students' questions. Subject matter mastery in the lecture positively predicted five tutoring skills and accounted for 25% of the variance in overall effectiveness of the PBL tutors (F=22.39, P=0.000. Other important predictors for tutoring skills were providing a relaxed class atmosphere and effective use of audiovisual aids in the lecture. Conclusion: Predicting the tutoring skills based on lecturing skills could have implications for recruiting tutors in PBL medical programs and for tutor training initiatives. Keywords: PBL, tutor, tutoring skills, lecturing skills

  7. Personalized multistep cognitive behavioral therapy for obesity

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    Dalle Grave R

    2017-06-01

    Full Text Available Riccardo Dalle Grave, Massimiliano Sartirana, Marwan El Ghoch, Simona Calugi Department of Eating and Weight Disorders, Villa Garda Hospital, Verona, Italy Abstract: Multistep cognitive behavioral therapy for obesity (CBT-OB is a treatment that may be delivered at three levels of care (outpatient, day hospital, and residential. In a stepped-care approach, CBT-OB associates the traditional procedures of weight-loss lifestyle modification, ie, physical activity and dietary recommendations, with specific cognitive behavioral strategies that have been indicated by recent research to influence weight loss and maintenance by addressing specific cognitive processes. The treatment program as a whole is delivered in six modules. These are introduced according to the individual patient’s needs in a flexible and personalized fashion. A recent randomized controlled trial has found that 88 patients suffering from morbid obesity treated with multistep residential CBT-OB achieved a mean weight loss of 15% after 12 months, with no tendency to regain weight between months 6 and 12. The treatment has also shown promising long-term results in the management of obesity associated with binge-eating disorder. If these encouraging findings are confirmed by the two ongoing outpatient studies (one delivered individually and one in a group setting, this will provide evidence-based support for the potential of multistep CBT-OB to provide a more effective alternative to standard weight-loss lifestyle-modification programs. Keywords: obesity, cognitive behavioral therapy, lifestyle modification, weight loss, weight maintenance, outcome

  8. Stress, anxiety, and depression among parents of children with autism spectrum disorder in Oman: a case–control study

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    Al-Farsi OA

    2016-08-01

    Full Text Available Omar A Al-Farsi,1 Yahya M Al-Farsi,1,2 Marwan M Al-Sharbati,3 Samir H Al-Adawi31Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman; 2Department of Epidemiology, School of Public Health, Boston, MA, USA; 3Department of Behavioural Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman Abstract: Previous studies carried out in Euro-American populations have unequivocally indicated that psychological disorders of the CASD (caregivers of children with autism spectrum disorder are marked with high levels of stress, anxiety, and depression. This finding has been attributed to the reaction of having to care for a child with neurodevelopmental disorders. While there have been reports on autism spectrum disorder in Arab/Islamic countries such as Oman, there is no study from this region, to our knowledge, reporting the performance of indices of stress, anxiety, and depression among CASD. This study aimed to examine whether there is variation in the performance of indices of stress, depression, and anxiety explored via Depression, Anxiety and Stress Scale 21 among CASD, caregivers of children with intellectual disabilities, and caregivers of typically developing children. All indices of stress, depression, and anxiety were higher in CASD compared to other caregivers in the control group. This study corroborates with other studies carried out in other populations that caring for children impacts the mental health status of caregivers. Therefore, there are strong grounds to contemplate the mechanism to help such a vulnerable group of family caregivers. Keywords: stress, anxiety, depression, caregivers, autism, Oman

  9. Unified functional network and nonlinear time series analysis for complex systems science: The pyunicorn package

    Science.gov (United States)

    Donges, Jonathan; Heitzig, Jobst; Beronov, Boyan; Wiedermann, Marc; Runge, Jakob; Feng, Qing Yi; Tupikina, Liubov; Stolbova, Veronika; Donner, Reik; Marwan, Norbert; Dijkstra, Henk; Kurths, Jürgen

    2016-04-01

    We introduce the pyunicorn (Pythonic unified complex network and recurrence analysis toolbox) open source software package for applying and combining modern methods of data analysis and modeling from complex network theory and nonlinear time series analysis. pyunicorn is a fully object-oriented and easily parallelizable package written in the language Python. It allows for the construction of functional networks such as climate networks in climatology or functional brain networks in neuroscience representing the structure of statistical interrelationships in large data sets of time series and, subsequently, investigating this structure using advanced methods of complex network theory such as measures and models for spatial networks, networks of interacting networks, node-weighted statistics, or network surrogates. Additionally, pyunicorn provides insights into the nonlinear dynamics of complex systems as recorded in uni- and multivariate time series from a non-traditional perspective by means of recurrence quantification analysis, recurrence networks, visibility graphs, and construction of surrogate time series. The range of possible applications of the library is outlined, drawing on several examples mainly from the field of climatology. pyunicorn is available online at https://github.com/pik-copan/pyunicorn. Reference: J.F. Donges, J. Heitzig, B. Beronov, M. Wiedermann, J. Runge, Q.-Y. Feng, L. Tupikina, V. Stolbova, R.V. Donner, N. Marwan, H.A. Dijkstra, and J. Kurths, Unified functional network and nonlinear time series analysis for complex systems science: The pyunicorn package, Chaos 25, 113101 (2015), DOI: 10.1063/1.4934554, Preprint: arxiv.org:1507.01571 [physics.data-an].

  10. Long-term weight loss maintenance for obesity: a multidisciplinary approach

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    Montesi L

    2016-02-01

    Full Text Available Luca Montesi,1 Marwan El Ghoch,2 Lucia Brodosi,1 Simona Calugi,2 Giulio Marchesini,1 Riccardo Dalle Grave2 1Unit of Metabolic Diseases, S Orsola-Malpighi Hospital, “Alma Mater Studiorum” University, Bologna, Italy; 2Department of Eating and Weight Disorders, Villa Garda Hospital, Verona, Italy Abstract: The long-term weight management of obesity remains a very difficult task, associated with a high risk of failure and weight regain. However, many people report that they have successfully managed weight loss maintenance in the long term. Several factors have been associated with better weight loss maintenance in long-term observational and randomized studies. A few pertain to the behavioral area (eg, high levels of physical activity, eating a low-calorie, low-fat diet; frequent self-monitoring of weight, a few to the cognitive component (eg, reduced disinhibition, satisfaction with results achieved, confidence in being able to lose weight without professional help, and a few to personality traits (eg, low novelty seeking and patient–therapist interaction. Trials based on the most recent protocols of lifestyle modification, with a prolonged extended treatment after the weight loss phase, have also shown promising long-term weight loss results. These data should stimulate the adoption of a lifestyle modification-based approach for the management of obesity, featuring a nonphysician lifestyle counselor (also called “lifestyle trainer” or “healthy lifestyle practitioner” as a pivotal component of the multidisciplinary team. The obesity physicians maintain a primary role in engaging patients, in team coordination and supervision, in managing the complications associated with obesity and, in selected cases, in the decision for drug treatment or bariatric surgery, as possible more intensive, add-on interventions to lifestyle treatment. Keywords: obesity, lifestyle modification, cognitive behavior therapy, multidisciplinary treatment

  11. Semianalytical solutions for contaminant transport under variable velocity field in a coastal aquifer

    Science.gov (United States)

    Koohbor, Behshad; Fahs, Marwan; Ataie-Ashtiani, Behzad; Simmons, Craig T.; Younes, Anis

    2018-05-01

    open source semi-analytical codes are made available at the website https://lhyges.unistra.fr/FAHS-Marwan.

  12. Noninfectious uveitis: strategies to optimize treatment compliance and adherence

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    Dolz-Marco R

    2015-08-01

    Full Text Available Rosa Dolz-Marco,1 Roberto Gallego-Pinazo,1 Manuel Díaz-Llopis,2 Emmett T Cunningham Jr,3–6 J Fernando Arévalo7,8 1Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, 2Faculty of Medicine, University of Valencia, Spain; 3Department of Ophthalmology, California Pacific Medical Center, San Francisco, 4Department of Ophthalmology, Stanford University School of Medicine, Stanford, 5The Francis I Proctor Foundation, University of California San Francisco Medical Center, 6West Coast Retina Medical Group, San Francisco, CA, USA; 7Vitreoretina Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 8Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: Noninfectious uveitis includes a heterogenous group of sight-threatening ocular and systemic disorders. Significant progress has been made in the treatment of noninfectious uveitis in recent years, particularly with regard to the effective use of corticosteroids and non-corticosteroid immunosuppressive drugs, including biologic agents. All of these therapeutic approaches are limited, however, by any given patient’s ability to comply with and adhere to their prescribed treatment. In fact, compliance and adherence are among the most important patient-related determinants of treatment success. We discuss strategies to optimize compliance and adherence. Keywords: noninfectious uveitis, intraocular inflammation, immunosuppressive treatment, adherence, compliance, therapeutic failure

  13. Arab Americans in Literature and the Media

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    Mita Banerjee

    2008-12-01

    Full Text Available Hollywood has a long history of stereotyping the Arab. From The Cafe in Cairo to The Siege, this Arab – invariably male – figures as the religious fundamentalist who sees in terrorism the only way to spread Islam over the entire globe. Having said this, this is not to argue either that Hollywood is ideologically corrupt, or that Arab (Americans are the only ethnic group stereotyped in Hollywood's cultural imagination. Yet while Hollywood’s Orientalism, which is actually based on a fascination with ancient Middle Eastern heritage, reflects a stereotypical depiction of everything Arab, Arab American literature can be seen as the other side of this projection or stereotype. Where Hollywood dramatizes, through the busting of ancient statues for the cause of terrorism, the Arab's disregard for his own culture, novels such as Khaled Hosseini's The Kite Runner and Nada Awar Jarrar's Somewhere, Home set out to preserve precisely a distinct cultural heritage, and go on to celebrate the contemporaneity and complexity of diasporic Afghan and Lebanese experience.

  14. Magnitude and determinants of diabetic retinopathy among persons with diabetes registered at employee health department of a tertiary Eye Hospital of central Saudi Arabia

    Science.gov (United States)

    Khandekar, Rajiv; Al Hassan, Arif; Al Dhibi, Hassan; Al Bahlal, Abdullah; Al-Futais, Muneera

    2015-01-01

    Background: To estimate the magnitude and determinants of diabetic retinopathy (DR) among persons with diabetes registered at the employee health department of King Khaled Eye Specialist Hospital (KKESH). Methods: A retrospective review of medical records was conducted in 2013–14 at KKESH. The case record review extracted demographic, profile of diabetes, diabetic complications, and different blood indices to determine the status of potential risk factors. Ocular profile, especially DR was also noted. Results: Our cohort had 94 staff with diabetes. Eye examination was carried out in 51 (54.8%) of them. The rate of DR was 52% (95% confidence interval (CI) 28–66). Sight-threatening diabetic retinopathy (STDR) (proliferative DR and/or diabetic macular edema) was present in 40% of those examined. Good glycemic control was noted in 42% of participants. Duration of diabetes was associated with DR (P = 0.04). Good glycemic control was negatively associated to DR (odds ratio = 0.2 [95% CI 0.04–0.6]). The coverage of eye screening was 55% only. Laser treatment was given to 80% of STDR cases. The lens opacity and glaucoma rate was 15% and 8.3%, respectively. Conclusions: Low coverage for eye screening and laser treatment to diabetics among the staff of an eye hospital is a matter of concern. The underlying causes of low coverage of screening, digital fundus photography as a screening tool and management should be addressed. PMID:26903721

  15. Vision Screening of Ophthalmic Nursing Staff in a Tertiary Eye Care Hospital; Outcomes and ocular healthcare-seeking behaviours

    Directory of Open Access Journals (Sweden)

    Ruhi A. Khan

    2017-03-01

    Full Text Available Objectives: This study aimed to evaluate ocular healthcare-seeking behaviours and vision screening outcomes of nursing staff at a tertiary eye care hospital. Methods: This study was conducted between April and September 2016 among all 500 nurses employed at the King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Data were collected on age, gender, use of visual aids, the presence of diabetes, a history of refractive surgery and date of last ocular health check-up. Participants were tested using a handheld Spot™ Vision Screener (Welch Allyn Inc., Skaneateles Falls, New York, USA. Results: A total of 150 nurses participated in the study (response rate: 30.0%. The mean age was 41.2 ± 8.9 years old. Distance spectacles, reading spectacles and both types of spectacles were used by 37 (24.7%, 32 (21.3% and 10 (6.7% nurses, respectively. A total of 58 nurses (38.7% failed the vision screening test. Visual defects were detected for the first time in 13 nurses (8.7%. With regards to regular eye checkups, 77 participants (51.3% reported acceptable ocular healthcare-seeking behaviours; this factor was significantly associated with age and the use of visual aids (P <0.01 each. Conclusion: A high proportion of participants failed the vision screening tests and only half displayed good ocular healthcare-seeking behaviours. This is concerning as ophthalmic nurses are likely to face fewer barriers to eye care services than the general population.

  16. 9th May 2008 - Members of Saudi government visiting ATLAS control room and cavern with Technical Coordinator M. Nessi and Adviser to the Director-General D. Blechschmidt.

    CERN Multimedia

    Mona Schweizer

    2008-01-01

    CERN-HI-0804043 05: from left to right 1st row Mrs. Ibtesam Badhrees, ATLAS Collaboration user Mr. Nadhmi Al-Nassr, Interim President, King Abdullah University of Science and Technology, KAUST H.E. Dr. Khaled S. Al-Sultan, Rector, King Fahd University for Petroleum and Minerals Mr. Abdallah S. Jum’ah, President and Chief Executive Officer, Saudi Aramco H.E. Dr. Ibrahim A. Al-Assaf, Minister of Finance H.E. Dr. Abdul Rahman Al-Tuwaijri, Chairman of Capital Markets Authority H.E. Dr. Mohammed I. Al-Suwaiyel, President, King Abdul Aziz City for Science & Technology KACST; 2nd row Mr. Salim S. Al-Aydh, Senior Vice President – Engineering & Project Management, Saudi Aramco Mr. Khalid A. Al-Falih, Executive Vice President – Operations, Saudi Aramco Mr. A. Othman, Saudi Aramco Mr. Peter Woicke, Member of the Saudi Aramco Board of Directors Mr. Abdulaziz F. Al-Khayyal, Senior Vice President – Industrial Relations, Saudi Aramco Mr. James W. Kinnear, Retired President & Chief Executive Office...

  17. A review of the efficacy of mitomycin C in glaucoma filtration surgery

    Directory of Open Access Journals (Sweden)

    Al Habash A

    2015-10-01

    Full Text Available Ahmed Al Habash,1,2 Leyla Ali Aljasim,1 Ohoud Owaidhah,1 Deepak P Edward1,3 1King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 2Department of Ophthalmology, University of Dammam, Dammam, Saudi Arabia; 3Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: The success of trabeculectomy, which is considered the gold standard in the surgical treatment of glaucoma, depends on the wound healing response. The introduction of antiproliferative agents such as mitomycin C (MMC has increased the success rates of trabeculectomy. However, complications due to these agents can be challenging to manage. Hence, it is important to determine the most efficacious dose and duration of exposure. Multiple studies suggest that many factors, including but not limited to MMC preparation, different concentrations, different exposure times, and method of application may affect success rate, and these factors were reviewed in this article. We concluded that lower concentrations of MMC that are prepared and applied in a standardized fashion, such as that using the Mitosol® kit (for 2–3 minutes during trabeculectomy, could potentially provide trabeculectomy success rates similar to that reported with off-label preparations, and that such a treatment regime could result in in lower complication rates than higher doses of MMC. Keywords: mitomycin C, Mitosol, filtering surgery, trabeculectomy, outcomes

  18. The use of a virtual reality surgical simulator for cataract surgical skill assessment with 6 months of intervening operating room experience.

    Science.gov (United States)

    Sikder, Shameema; Luo, Jia; Banerjee, P Pat; Luciano, Cristian; Kania, Patrick; Song, Jonathan C; Kahtani, Eman S; Edward, Deepak P; Towerki, Abdul-Elah Al

    2015-01-01

    To evaluate a haptic-based simulator, MicroVisTouch™, as an assessment tool for capsulorhexis performance in cataract surgery. The study is a prospective, unmasked, nonrandomized dual academic institution study conducted at the Wilmer Eye Institute at Johns Hopkins Medical Center (Baltimore, MD, USA) and King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). This prospective study evaluated capsulorhexis simulator performance in 78 ophthalmology residents in the US and Saudi Arabia in the first round of testing and 40 residents in a second round for follow-up. Four variables (circularity, accuracy, fluency, and overall) were tested by the simulator and graded on a 0-100 scale. Circularity (42%), accuracy (55%), and fluency (3%) were compiled to give an overall score. Capsulorhexis performance was retested in the original cohort 6 months after baseline assessment. Average scores in all measured metrics demonstrated statistically significant improvement (except for circularity, which trended toward improvement) after baseline assessment. A reduction in standard deviation and improvement in process capability indices over the 6-month period was also observed. An interval objective improvement in capsulorhexis skill on a haptic-enabled cataract surgery simulator was associated with intervening operating room experience. Further work investigating the role of formalized simulator training programs requiring independent simulator use must be studied to determine its usefulness as an evaluation tool.

  19. Evaluation of diabetes care management in primary clinics based on the guidelines of American Diabetes Association.

    Science.gov (United States)

    Albarrak, Ahmed Ismail; Mohammed, Rafiuddin; Assery, Bushra; Allam, Dalya; Morit, Sarah Al; Saleh, Reem Al; Zare'a, Reem

    2018-01-01

    There is a rapid increase in the incidence of diabetes mellitus in Saudi Arabia. Diabetes management is an essential constituent to prevent prognosis of diabetes complications. The main objective of this study was to assess diabetes care in primary clinics based on the guidelines of American Diabetes Association (ADA). A retrospective study at King Khaled University Hospitals, Riyadh, Saudi Arabia. A total of 200 patients were randomly selected from the databases of primary care clinics. An evaluation checklist was created based on the ADA treatment guidelines such as medical history, physical examination, laboratory evaluation, and referrals. The result showed that elements achieving the ADA targets for overall care were medical history (44.9%), physical examination (59.6%), laboratory evaluation (36.3%), and referrals (19.3%). The other subelement indicators such as referral to diabetes self-management education clinics (10%), dental examination (2%), HbA1c regular monitoring (33.5%), and blood pressure determination (100%) were documented with adherence to ADA standards. Diabetes management standards are an essential element in the success of the management plan. Most of the elements examined are not in full compliance with the ADA standard. Continues monitoring and self-review are recommended.

  20. Magnitude and determinants of diabetic retinopathy among persons with diabetes registered at employee health department of a tertiary Eye Hospital of central Saudi Arabia.

    Science.gov (United States)

    Khandekar, Rajiv; Al Hassan, Arif; Al Dhibi, Hassan; Al Bahlal, Abdullah; Al-Futais, Muneera

    2015-01-01

    To estimate the magnitude and determinants of diabetic retinopathy (DR) among persons with diabetes registered at the employee health department of King Khaled Eye Specialist Hospital (KKESH). A retrospective review of medical records was conducted in 2013-14 at KKESH. The case record review extracted demographic, profile of diabetes, diabetic complications, and different blood indices to determine the status of potential risk factors. Ocular profile, especially DR was also noted. Our cohort had 94 staff with diabetes. Eye examination was carried out in 51 (54.8%) of them. The rate of DR was 52% (95% confidence interval (CI) 28-66). Sight-threatening diabetic retinopathy (STDR) (proliferative DR and/or diabetic macular edema) was present in 40% of those examined. Good glycemic control was noted in 42% of participants. Duration of diabetes was associated with DR (P = 0.04). Good glycemic control was negatively associated to DR (odds ratio = 0.2 [95% CI 0.04-0.6]). The coverage of eye screening was 55% only. Laser treatment was given to 80% of STDR cases. The lens opacity and glaucoma rate was 15% and 8.3%, respectively. Low coverage for eye screening and laser treatment to diabetics among the staff of an eye hospital is a matter of concern. The underlying causes of low coverage of screening, digital fundus photography as a screening tool and management should be addressed.

  1. Endophthalmitis associated with the Ahmed glaucoma valve implant.

    Science.gov (United States)

    Al-Torbak, A A; Al-Shahwan, S; Al-Jadaan, I; Al-Hommadi, A; Edward, D P

    2005-04-01

    To investigate the rate, risk factors, clinical course, and treatment outcomes of endophthalmitis following glaucoma drainage implant (GDI) surgery. A computerised relational database search was conducted to identify all patients who were implanted with Ahmed glaucoma valve (AGV) and developed endophthalmitis following surgery at the King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia, between 1 January 1994 and 30 November 2003. Only medical records of the patients who developed endophthalmitis were retrospectively reviewed. 542 eyes of 505 patients who were on active follow up were included in the study. Endophthalmitis developed in nine (1.7%) eyes; the rate was five times higher in children than in adults. Delayed endophthalmitis (developed 6 weeks after surgery) occurred in eight of nine eyes. Conjunctival erosion overlying the AGV tube was present in six of nine eyes. Common organisms isolated in the vitreous included Haemophilus influenzae and Streptococcus species. Multiple regression analysis revealed that younger age and conjunctival erosion over the tube were significant risk factors associated with endophthalmitis. Endophthalmitis is a rare complication of GDI surgery that appears to be more common in children. Conjunctival dehiscence over the GDI tube seems to represent a major risk factor for endophthalmitis. Prompt surgical revision of an exposed GDI tube is highly recommended.

  2. Endophthalmitis associated with the Ahmed glaucoma valve implant

    Science.gov (United States)

    Al-Torbak, A A; Al-Shahwan, S; Al-Jadaan, I; Al-Hommadi, A; Edward, D P

    2005-01-01

    Aim: To investigate the rate, risk factors, clinical course, and treatment outcomes of endophthalmitis following glaucoma drainage implant (GDI) surgery. Methods: A computerised relational database search was conducted to identify all patients who were implanted with Ahmed glaucoma valve (AGV) and developed endophthalmitis following surgery at the King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia, between 1 January 1994 and 30 November 2003. Only medical records of the patients who developed endophthalmitis were retrospectively reviewed. Results: 542 eyes of 505 patients who were on active follow up were included in the study. Endophthalmitis developed in nine (1.7%) eyes; the rate was five times higher in children than in adults. Delayed endophthalmitis (developed 6 weeks after surgery) occurred in eight of nine eyes. Conjunctival erosion overlying the AGV tube was present in six of nine eyes. Common organisms isolated in the vitreous included Haemophilus influenzae and Streptococcus species. Multiple regression analysis revealed that younger age and conjunctival erosion over the tube were significant risk factors associated with endophthalmitis. Conclusion: Endophthalmitis is a rare complication of GDI surgery that appears to be more common in children. Conjunctival dehiscence over the GDI tube seems to represent a major risk factor for endophthalmitis. Prompt surgical revision of an exposed GDI tube is highly recommended. PMID:15774923

  3. Prevalence of Methicillin-resistant Staphyloccocus Aureus and associated risk factors on admission to a specialist care eye hospital

    International Nuclear Information System (INIS)

    Islam, Sara I.; Moore, C.

    2002-01-01

    Staphyloccocus aureus is known to be a frequent pathogen in hospital settings, with its well-known and resistant forms to the anti-staphylococcal penicillins. Reports on community carriage outside hospital settings have been feared to be on the increase due to the due to the frequency of reported cases on admission to hospitals. We undertook this study to determine the prevalence of and to establish predictors for, nasal carriage of methicillin-resistant S.aureus (MRSA) at the time of admission to a specialist care eye hospital. A prospective survey was conducted at King Khaled Eye Specialist Hospital (KKESH), Riyadh during the three differing weeks randomly selected from the year 1999. The first 100 patients admitted during those three weeks were selected according to inclusion criteria. The hospital is a 220-bed tertiary ophthalmic care facility, with an average 7,500admission per year. Nasal bacterial swabs were taken within 48 hours of admission and tested for all strains of S.aureus and sensitivity to methicillin. Detailed interviews were conducted about medical history and habitual environment. Of 306 nasal cultures tested, none was isolated for MRSA and 102 (33%) were sensitive to methicillin (MSSA).We found 0% nasal carriage rate for MRSA. Respondents have difficulty with questions related to antibiotic administration. No identifiable medical or environmental risk factors could be found. Nasal swabs of patients admitted to KKESH did not reveal MRSA colonization, indicating that MRSA may not be prevalent in the community at present. (author)

  4. The educational environment of the undergraduate medical curriculum at Kuwait University

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    Karim J

    2015-04-01

    Full Text Available Jumanah Karim,1 Becher Al-Halabi,2 Yousef Marwan,3 Hussain Sadeq,4 Ahmed Dawas,5 Dalia Al-Abdulrazzaq5 1Department of Pediatrics, Al-Amiri Hospital, Kuwait City, Kuwait; 2Department of Surgery, Mubarak Al-Kabeer Hospital, Kuwait City, Kuwait; 3Department of Orthopaedic Surgery, Al-Razi Orthopaedic Hospital, Kuwait City, Kuwait; 4Department of Pediatrics, Al-Adan Hospital, Kuwait City, Kuwait; 5Department of Pediatrics, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait City, Kuwait Background: Educational environment of an institution affects the quality of learning. We aim to assess the educational environment of the undergraduate curriculum of Faculty of Medicine, Kuwait University (FOMKU. Methods: A cross-sectional study was carried out during April 2014. The validated Dundee Ready Education Environment Measure (DREEM questionnaire was e-mailed to 607 students. Mean scores of the main domains of the questionnaire, and for each item, were calculated, and their association with the students’ background information was measured using Student’s t-test (P-value of ≤0.05 was considered as the cut-off level of significance. Results: Of 607 students, 117 (19.3% completed the questionnaire. The total mean score for DREEM was 108.7/200 (54.3%. The mean score for students’ perception of teaching, perception of teachers, academic self-perception, perception of atmosphere, and social self-perception were 25.2/48 (52.5%, 24.6/44 (55.9%, 18.4/32 (57.5%, 26.2/48 (54.5%, and 14.3/28 (51.0%, respectively. The highest mean score for an item of DREEM questionnaire was for “my accommodation is pleasant” (3.48±0.75, while the lowest was for “there is a good support system for students who get stressed” (0.88±0.86. The total mean score was not significantly different between the two phases of the curriculum, or among males and females; however, few significant differences among the main domains and items were noted. Conclusion

  5. Extracurricular research activities among senior medical students in Kuwait: experiences, attitudes, and barriers

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    Al-Halabi B

    2014-04-01

    Full Text Available Becher Al-Halabi,1 Yousef Marwan,2 Mohammad Hasan,3 Sulaiman Alkhadhari41Department of Surgery, Mubarak Al-Kabeer Hospital, Ministry of Health, Kuwait; 2Department of Orthopaedic Surgery, Al-Razi Hospital, Al-Sabah Medical Area, Ministry of Health, Kuwait; 3Department of Radiation Oncology, Kuwait Cancer Control Center, Al-Sabah Medical Area, Ministry of Health, Kuwait; 4Department of Psychiatry, Faculty of Medicine, Health Sciences Center, Kuwait University, KuwaitBackground: Research is the foundation of scientific advancement and improvement in quality of health care, which ensures the good health of the community. The aim of this study is to explore experiences, attitudes, and barriers of medical students in Kuwait University (KU in regards to extracurricular research.Methods: A questionnaire about extracurricular research activities (ie, any research activity that is not part of the required undergraduate curriculum, such as publishing a paper, research elective, etc was distributed to 175 senior medical students (years 6 and 7. Descriptive and chi-square analyses were used to analyze the responses, considering a P-value of <0.05 as the cut-off level for significance. The main outcome was defined as taking part in any of the extracurricular research activities.Results: Of the 150 participants (response rate = 85.7%, 26 (17.3%, 68 (45.3%, 52 (34.7%, and 17 (11.3% had published their required medical school research, presented abstracts in conferences, conducted extracurricular research, and completed a research elective/course, respectively; 99 (66.0% took part in any of these activities. Participants who read medical journals regularly (81; 54% reported higher participation in extracurricular research activities than those who did not read journals (P=0.003. Improving the availability of mentors for students' extracurricular research was ranked by the participants as the most important factor to improve their participation in

  6. Quantifying Stability in Complex Networks: From Linear to Basin Stability

    Science.gov (United States)

    Kurths, Jürgen

    understanding of evolving networks. Reference: P. Menck, J. Heitzig, N. Marwan, and J. Kurths, Nature Physics 9, 89 (2013) P. Menck, J. Heitzig, J. Kurths, and H. Schellnhuber, Nature Communication 5, 3969 (2014) P. Schultz, J. Heitzig, and J. Kurths, New Journal Physics 16, 125001 (2014) V. Kohar, P. Ji, A. Choudhary, S. Sinha, and J. Kurths, Phys. Rev. E 90, 022812 (2014) Y. Zou, T. Pereira, M. Small, Z. Liu, and J. Kurths, Phys. Rev. Lett. 112, 114102 (2014)

  7. Limbal stem cell transplantation: current perspectives

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    Atallah MR

    2016-04-01

    Full Text Available Marwan Raymond Atallah, Sotiria Palioura, Victor L Perez, Guillermo Amescua Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA Abstract: Regeneration of the corneal surface after an epithelial insult involves division, migration, and maturation of a specialized group of stem cells located in the limbus. Several insults, both intrinsic and extrinsic, can precipitate destruction of the delicate microenvironment of these cells, resulting in limbal stem cell deficiency (LSCD. In such cases, reepithelialization fails and conjunctival epithelium extends across the limbus, leading to vascularization, persistent epithelial defects, and chronic inflammation. In partial LSCD, conjunctival epitheliectomy, coupled with amniotic membrane transplantation, could be sufficient to restore a healthy surface. In more severe cases and in total LSCD, stem cell transplantation is currently the best curative option. Before any attempts are considered to perform a limbal stem cell transplantation procedure, the ocular surface must be optimized by controlling causative factors and comorbid conditions. These factors include adequate eyelid function or exposure, control of the ocular surface inflammatory status, and a well-lubricated ocular surface. In cases of unilateral LSCD, stem cells can be obtained from the contralateral eye. Newer techniques aim at expanding cells in vitro or in vivo in order to decrease the need for large limbal resection that may jeopardize the “healthy” eye. Patients with bilateral disease can be treated using allogeneic tissue in combination with systemic immunosuppressive therapy. Another emerging option for this subset of patients is the use of noncorneal cells such as mucosal grafts. Finally, the use of keratoprosthesis is reserved for patients who are not candidates for any of the aforementioned options, wherein the choice of the type of keratoprosthesis depends on

  8. Multidisciplinary management of clear-cell renal cell carcinoma in Africa and the Middle East: current practice and recommendations for improvement

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    Zekri J

    2015-07-01

    Full Text Available Jamal Zekri,1 Lydia M Dreosti,2 Marwan Ghosn,3 Emad Hamada,4 Mohamed Jaloudi,5 Ola Khorshid,6 Blaha Larbaoui7 1College of Medicine, King Faisal Specialist Hospital and Research Centre, Alfaisal University, Jeddah, Saudi Arabia; 2Department of Medical Oncology, University of Pretoria, Pretoria, South Africa; 3Faculty of Medicine Hematology, Oncology Department, Saint Joseph University, Beirut, Lebanon; 4Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, Egypt; 5Oncology Hematology Department, Tawam Hospital, Al Ain, Abu Dhabi, United Arab Emirates; 6National Cancer Institute, Cairo University, Kasr El Ainy, Cairo, Egypt; 7Oncology Service, Université Djillali Liabés, Sidi Bel Abbés, Algeria Abstract: The management of renal cell carcinoma (RCC has evolved considerably in recent years. This report represents the consensus of 22 relevant medical specialists from Africa and the Middle East region engaged in the management of RCC. Partial or radical nephrectomy is the standard of care for most patients with localized RCC. It is essential that patients are followed up appropriately after surgery to enable local and distant relapses to be identified and treated promptly. The treatment of advanced/metastatic disease has changed dramatically with the introduction of targeted therapies. Follow-up of these patients enables therapy optimization and assessment of response to treatment. There was universal agreement on the importance of management of RCC by a multidisciplinary team supported by a multidisciplinary tumor board. Barriers hindering this approach were identified. These included lack of awareness of the benefits of multidisciplinary team role, poor communication among relevant disciplines, time constraints, and specifics of private practice. Other challenges include shortage of expert specialists as urologists and oncologists and lack of local management guidelines in some countries. Solutions were proposed and discussed. Medical

  9. The association of systemic disorders with Vogt-Koyanagi-Harada and sympathetic ophthalmia.

    Science.gov (United States)

    Al-Halafi, Ali; Dhibi, Hassan Al; Hamade, Issam H; Bou Chacra, Charbel T; Tabbara, Khalid F

    2011-08-01

    The aim of this work is to determine the systemic diseases and malignancy associated with Vogt-Koyanagi-Harada (VKH) disease compared to sympathetic ophthalmia (SO). We conducted a retrospective comparative observational clinical study where the medical records of patients with the diagnosis of VKH and SO from 1999-2009 were reviewed. The study was carried out at the King Khaled Eye Specialist Hospital and The Eye Center in Riyadh, Saudi Arabia. Investigators recorded the age, gender, history of trauma, associated systemic disorders, and ocular and systemic manifestations. Patients were examined by an ophthalmologist as well as an internist. A total of 316 patients were included: 256 patients had VKH and 60 patients had SO. The age range in the VKH group was 3-62 years with a mean age of 29 ± 13 years. The age range in the SO group was 4-90 years with a mean age of 36 ± 20 years. The mean follow-up period of patients with VKH was 58 ± 50 months and patients with SO was 61 ± 54 months. Out of 256 patients with VKH, there were 41 (16%) with systemic disorders. Comparatively, out of 60 patients with SO, no associated systemic autoimmune disorders or tumors were encountered. The difference between the VKH and SO groups was statistically significant (p = 0.003). VKH and SO are autoimmune disorders targeting melanin-bearing cells. Both diseases are characterized by immunologic dysregulation. We found a statistically significant association of systemic disorders and malignancy with VKH compared to SO. This finding may suggest that the two disorders may have different etiology with similar ocular and systemic manifestations.

  10. Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia

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    Hosny KM

    2015-01-01

    Full Text Available Khaled Mohamed Hosny,1,2 Zainy Mohammed Banjar,3 Amani H Hariri,4 Ali Habiballah Hassan5 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt; 3Department of Clinical Biochemistry, Faculty of medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 4Consultant Obstetrics and Gynecology, Hera Genaral Hospital, Makkah, Saudi Arabia; 5Department of Orthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: According to the World Health Organization, 46% of the world’s children suffer from anemia, which is usually treated with iron supplements such as ferrous sulfate. The aim of this study was to prepare iron as solid lipid nanoparticles, in order to find an innovative way for alleviating the disadvantages associated with commercially available tablets. These limitations include adverse effects on the digestive system resulting in constipation and blood in the stool. The second drawback is the high variability in the absorption of iron and thus in its bioavailability. Iron solid lipid nanoparticles (Fe-SLNs were prepared by hot homogenization/ultrasonication. Solubility of ferrous sulfate in different solid lipids was measured, and effects of process variables such as the surfactant type and concentration, homogenization and ultrasonication times, and charge-inducing agent on the particle size, zeta potential, and encapsulation efficiency were determined. Furthermore, in vitro drug release and in vivo pharmacokinetics were studied in rabbits. Results indicated that Fe-SLNs consisted of 3% Compritol 888 ATO, 1% Lecithin, 3% Poloxamer 188, and 0.2% dicetylphosphate, with an average particle size of 25 nm with 92.3% entrapment efficiency. In vivo pharmacokinetic study revealed more than fourfold enhanced bioavailability. In

  11. Rhegmatogenous retinal detachments associated to Stickler syndrome in a tertiary eye care center in Saudi Arabia

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    Alshahrani ST

    2015-12-01

    Full Text Available Saeed T Alshahrani,1 Nicola G Ghazi,2 Saba Al-Rashaed2 1Ophthalmology Department, King Fahad Specialist Hospital, Dammam, 2Vitreoretinal Department, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia Purpose: To investigate the clinical findings and outcomes of rhegmatogenous retinal detachment (RRD in Stickler syndrome on affected and fellow eyes that underwent prophylactic retinopexy.Patients and methods: Chart review of 70 eyes (62 patients. Incidence of RRD, postoperative visual acuity, and risk factors were evaluated.Results: Twenty-two patients (35% had RRD in the fellow eye, 37% of the eyes had cataract, 93% had macular detachment, 50% had proliferative vitreoretinopathy, and 41% had posterior vitreous detachment. Success rates were: 60% of patients after scleral buckling; 57.1% after pars plana vitrectomy; and 75% after combined scleral buckling and pars plana vitrectomy. Sixty-one (93.8% of patients had successful surgery (including second surgery. Silicone oil tamponade was significantly associated with final anatomic outcome, with a protective odds ratio of 0.11 (P=0.027. Visual acuity improved in 54% of eyes and decreased in 5%. Statistically significant associations were present for eyes with final visual acuity ≥20/200, and total retinal detachment (P<0.001; preoperative cataract (P=0.023; and proliferative vitreoretinopathy (P<0.001. RRD developed in 16/44 eyes despite laser prophylaxis.Conclusion: Prophylactic retinopexy was not beneficial for Stickler syndrome patients. Success of primary surgery for RRD remains low. The primary surgery should be vitrectomy combined with scleral buckling and silicone oil tamponade. Keywords: Stickler syndrome, retinopexy, Gulf States, Saudi Arabia, ocular genetics, arthro-ophthalmopathy, collagen disorder

  12. Polymerase chain reaction in unilateral cases of presumed viral anterior uveitis

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    Shoughy SS

    2015-12-01

    Full Text Available Samir S Shoughy,1 Hind M Alkatan,2,4 Abdulelah A Al-Abdullah,2 Albarah El-Khani,2 Jolanda DF de Groot-Mijnes,3 Khalid F Tabbara1,4,5 1Department of Ophthalmology, The Eye Center and The Eye Foundation for Research in Ophthalmology, 2Department of Pathology & Laboratory Medicine and Uveitis Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 3Department of Virology and Ophthalmology, University Medical Center Utrecht, Utrecht, the Netherlands; 4Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 5The Wilmer Ophthalmological Institute of The Johns Hopkins University School of Medicine, Baltimore, MD, USA Background and objectives: Anterior uveitis is the most common form of intraocular inflammation. The main aim of this study was to determine the viral etiology in patients with unilateral cases of anterior uveitis.Patients and methods: A total of 12 consecutive patients with the diagnosis of idiopathic unilateral anterior uveitis were included prospectively. Aqueous specimens were obtained from each patient by anterior chamber paracentesis and subjected to the detection of viral DNA/RNA genome by polymerase chain reaction assay for herpes simplex virus, varicella zoster virus, cytomegalovirus, Epstein–Barr virus, and rubella virus.Results: There were six male and six female patients. The mean age was 43 years, with an age range of 11–82 years. All 12 cases presented with unilateral anterior uveitis. In four (33% patients, polymerase chain reaction was positive for viral genome. Two patients were positive for herpes simplex virus type 1, one patient was positive for cytomegalovirus and one for Epstein–Barr virus.Conclusion: Recent molecular diagnostic assays would help in the identification of the causative agent in patients with unilateral anterior uveitis. Keywords: viral anterior uveitis, PCR, herpes simplex virus, cytomegalovirus, diffuse keratic precipitates, anterior chamber

  13. Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients

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    Olfat Shaker

    2009-12-01

    Full Text Available Olfat Shaker1, Amr Zahra2, Ahmed Sayed3, Ayman Refaat4, Zakaria El-Khaiat5, Gehan Hegazy5, Khaled El-Hindawi3, Mohamed Ay-El Deen31Department of Medical Biochemistry, 3Vascular Surgery, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Department of Medical Biochemistry, Faculty of Medicine, Fayoum University, Al Fayyum, Egypt; 4Vasular Surgery, Faculty of Medicine, Beni Suef University, Beni-Suef, Egypt; 5Medical Biochemistry Department, National Research Center, Cairo, EgyptBackground: Intercellular adhesion molecule-1 (ICAM-1 and E-selectin have been shown to predict cardiovascular disease (CVD such as myocardial infarction, stroke, and peripheral arterial occlusive disease (PAOD.Methods: Two mutations, S128R in E-selectin and K469E in ICAM-1, were investigated in 156 patients with PAOD and 100 control subjects using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP analysis in an Egyptian population.Results: The distribution of E-selectin genotypes in patients affected by PAOD was 84.6% for the AA genotype and 15.4% for the AC genotype. In the control arm the distribution was 97% for the AA genotype and 3% for the AC genotype. There was a statistically significance difference in the distribution of the AC genotype in PAOD patients when compared with the control subjects. Additionally, the distribution of ICAM-1 genotypes in patients affected by PAOD was 30.8% with the EE, 48% with the EK, and 21.2% with the KK genotypes. The distribution of ICAM-1 genotypes in control subjects was 13% EE, 33% EK and 54% KK. The EE genotype was significantly more common in PAOD patients than in the controls.Conclusion: S128R and K469E polymorphisms were associated with increased risk in PAOD. Early detection of these polymorphic genes helps in early prophylaxis against PAOD.Keywords: polymorphism, PAOD, E-selectin, ICAM-1, RFLP, genotyping

  14. The association of exposure to the 2009 south war with the physical, psychological, and family well-being of Saudi children.

    Science.gov (United States)

    El Hatw, Mohamed M; El Taher, Aly A; El Hamidi, Ahmed; Alturkait, Fawziyah A

    2015-01-01

    To evaluate the nutritional, psychological, behavioral, family adjustment, and psychiatric assessment of Saudi children exposed to the 2009-2010 Jazan war. This retrospective cohort study was conducted in Saudi Arabia in July 2010. One hundred and eighty-six children exposed to the South war in Jazan, and 157 unexposed children in King Khaled Military City, Hafr Al Batin were studied for evidence of malnutrition using physical measures, evaluating psychological problems using the Child Behavior Inventory, behavioral problems using the Rutter Scale A2, family adjustment using the McMaster Family adjustment device, and for psychiatric disorders. The association of different socioeconomic variables with the psychological outcome of the exposed group was also studied. The exposed children were well nourished, had more anxiety (p=0.044), better adaptation (p<0.001), less aggression (p=0.025), less deviant behavior (p=0.007), better family adjustment and had more post traumatic stress disorder, generalized anxiety, nightmares, and grief reaction. In the exposed children, females had more anxiety (p=0.006), and males had more antisocial behavior (p=0.02). Older children had less deviant behavior (p=0.005), better adaptation (p=0.007) and better planful behavior (p<0.001). Children of elder mothers had better planful behavior (p=0.039). Children from bigger families were less aggressive (p=0.049), and had less antisocial behavior (p=0.04). This study found that children exposed to the Jazan war had more anxiety. Unexpectedly they were well nourished and had higher adaptation, lower antisocial behavior, and better family adjustment. The socioeconomic status was associated with the psychological outcome. 

  15. Biochemical and Haematological Blood Parameters at Different Stages of Lactation in Cows

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    Cristian Ovidiu COROIAN

    2017-05-01

    Full Text Available The health status of cows is evaluated and depending on haematological and biochemical profile of blood. Nutrition is the main technological factor that can produce profound changes in the metabolic profile in animals (Dhiman et al., 1991; Khaled et al., 1999; Ingvartsen, 2006. Blood parameters analyze can lead to identify if there are errors in nutrition of lactating cows (Payne et al., 1970. The aim of this study was the evaluation of metabolic and biochemical changes that occur during colostrum period and in terms of number of lactations in cows. The biological material was represented by a total of 60 heads of dairy cows from a family farm from Sălaj County, Romania. The cows are all from Holstein breed and presented no clinical signs of any specific pathology. Blood samples were collected from the jugular vein of each cow and analyzed. 10 individuals from each of the six lactations have been randomly selected. Haematological and biochemical parameters showed variations depending on factors analyzed here. In lactation 1 Hb was 7.55±3.05 (g/dl, while in lactation 6 the value was 12.5±2.10 (g/dl. RBC ranged as follows: in lactation 1 - 28.50±2.05 and in lactation 6 - 30.02±2.05. Lymphocytes varied within very wide limits under the influence of lactation: in lactation 1 - 2.8±1.56 and in lactation 6 - 7.55±1.80. The number of lactations and lactation rank have influenced blood biochemical and hematological parameters in dairy cows. Biochemical parameters are influenced by post-partum day, showing the lowest values in the early days of colostral period and the highest in the last few days of the same period.

  16. Assessment of surgeon fatigue by surgical simulators

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    Tuwairqi K

    2015-04-01

    Full Text Available Khaled Tuwairqi,1 Jessica H Selter,2 Shameema Sikder3 1College of Medicine, University of Utah, Salt Lake City, UT, 2Johns Hopkins School of Medicine, 3Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA Background: The impact of fatigue on surgical performance and its implications for patient care is a growing concern. While investigators have employed a number of different tools to measure the effect of fatigue on surgical performance, the use of the surgical simulator has been increasingly implemented for this purpose. The goal of this paper is to review the published literature to achieve a better understanding of evaluation of fatigue on performance as studied with surgical simulators. Methods: A PubMed and Cochrane search was conducted using the search terms “simulator”, “surgery”, and “fatigue”. In total, 50 papers were evaluated, and 20 studies were selected after application of exclusion criteria. Articles were excluded if they did not use the simulator to assess the impact of fatigue on surgeon performance. Systematic reviews and case reports were also excluded. Results: Surgeon fatigue led to a consistent decline in cognitive function in six studies. Technical skills were evaluated in 18 studies, and a detrimental impact was reported in nine studies, while the remaining nine studies showed either no change or positive results with regard to surgical skills after experience of fatigue. Two pharmacological intervention studies reversed the detrimental impact of fatigue on cognitive function, but no change or a worsening effect was recognized for technical skills. Conclusion: Simulators are increasingly being used to evaluate the impact of fatigue on the surgeon's performance. With regard to the impact of fatigue in this regard, studies have demonstrated a consistent decline in cognitive function and mixed outcomes for technical skills. Larger studies that relate the simulator's results to real surgical

  17. Styrene maleic acid-encapsulated RL71 micelles suppress tumor growth in a murine xenograft model of triple negative breast cancer

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    Martey O

    2017-10-01

    Full Text Available Orleans Martey,1 Mhairi Nimick,1 Sebastien Taurin,1 Vignesh Sundararajan,1 Khaled Greish,2 Rhonda J Rosengren1 1Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain Abstract: Patients with triple negative breast cancer have a poor prognosis due in part to the lack of targeted therapies. In the search for novel drugs, our laboratory has developed a second-generation curcumin derivative, 3,5-bis(3,4,5-trimethoxybenzylidene-1-methylpiperidine-4-one (RL71, that exhibits potent in vitro cytotoxicity. To improve the clinical potential of this drug, we have encapsulated it in styrene maleic acid (SMA micelles. SMA-RL71 showed improved biodistribution, and drug accumulation in the tumor increased 16-fold compared to control. SMA-RL71 (10 mg/kg, intravenously, two times a week for 2 weeks also significantly suppressed tumor growth compared to control in a xenograft model of triple negative breast cancer. Free RL71 was unable to alter tumor growth. Tumors from SMA-RL71-treated mice showed a decrease in angiogenesis and an increase in apoptosis. The drug treatment also modulated various cell signaling proteins including the epidermal growth factor receptor, with the mechanisms for tumor suppression consistent with previous work with RL71 in vitro. The nanoformulation was also nontoxic as shown by normal levels of plasma markers for liver and kidney injury following weekly administration of SMA-RL71 (10 mg/kg for 90 days. Thus, we report clinical potential following encapsulation of a novel curcumin derivative, RL71, in SMA micelles. Keywords: curcumin derivatives, nanomedicine, EGFR, biodistribution

  18. A combination of sorafenib and nilotinib reduces the growth of castrate-resistant prostate cancer

    Directory of Open Access Journals (Sweden)

    Archibald M

    2016-01-01

    Full Text Available Monica Archibald,1 Tara Pritchard,1 Hayley Nehoff,1 Rhonda J Rosengren,1 Khaled Greish,1,2 Sebastien Taurin1 1Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Aljawhara Centre for Molecular Medicine, Arabian Gulf University, Manama, Kingdom of Bahrain Abstract: Castrate-resistant prostate cancer (CRPC remains incurable due to the lack of effective therapies. Several tyrosine kinases have been implicated in the development and growth of CRPC, as such targeting these kinases may offer an alternative therapeutic strategy. We established the combination of two tyrosine kinase inhibitors (TKIs, sorafenib and nilotinib, as the most cytotoxic. In addtion, to improve their bioavailability and reduce their metabolism, we encapsulated sorafenib and nilotinib into styrene-co-maleic acid micelles. The micelles’ charge, size, and release rate were characterized. We assessed the effect of the combination on the cytotoxicity, cell cycle, apoptosis, protein expression, tumor spheroid integrity, migration, and invasion. The micelles exhibited a mean diameter of 100 nm, a neutral charge, and appeared highly stable. The micellar TKIs promoted greater cytotoxicity, decreased cell proliferation, and increased apoptosis relative to the free TKIs. In addition, the combination reduced the expression and activity of several tyrosine kinases and reduced tumor spheroid integrity and metastatic potential of CRPC cell lines more efficiently than the single treatments. The combination increased the therapeutic potential and demonstrated the relevance of a targeted combination therapy for the treatment of CRPC. In addition, the efficacy of the encapsulated drugs provides the basis for an in vivo preclinical testing. Keywords: sorafenib, nilotinib, castrate-resistant prostate cancer, tyrosine kinase inhibitors, nanomedicine

  19. Sociodemographic factors responsible for blindness in diabetic Egyptian patients

    Directory of Open Access Journals (Sweden)

    Abueleinen KGI

    2011-11-01

    Full Text Available Khaled Gamal Ibraheem Abueleinen1, Hany El-Mekawey1, Yasser Sayed Saif2, Amr Khafagy1, Hoda Ibrahim Rizk3, Eman M Eltahlawy41Department of Ophthalmology, Cairo University, Cairo, Egypt; 2Department of Ophthalmology, Beni-Suef University, Beni-Suef, Egypt; 3Department of Public Health, Cairo University, Cairo, Egypt; 4Public Health and Community Medicine National Research Center, Cairo, EgyptPurpose: To evaluate factors behind the delay in diagnosis and treatment among Egyptian patients who present with complicated diabetic retinopathy.Methods: Observational cross-sectional study of diabetic patients with advanced diabetic retinopathy. Patients were asked to answer a questionnaire to assess the impact of several sociodemographic factors.Results: A total of 397 patients agreed to take the questionnaire. Diabetic vitreous hemorrhage was the most common ocular complication and was found in 359 patients (90.4%. A total of 158 (39.8% patients knew that diabetes mellitus can be sight threatening, while 240 (60.2% were not aware until they developed sight threatening complication. A total of 179 patients (45.1% had early retirement because of visual loss related to diabetes mellitus. Multivariate logistic regression has shown that education, internist, contact with other patients, and media were respectively significant in predicting the awareness of patients about the sight-threatening effect of diabetic retinopathy.Conclusion: Patient education regarding diabetes and diabetic eye disease is essential for early detection and compliance with treatment. Illiteracy has a significant impact on development of sight-threatening diabetic complications. The internist is the first line of prophylaxis. Media has to participate more in patient education.Keywords: blindness, education, laser photocoagulation, macular edema, vitreous hemorrhage

  20. 2008. aasta tõlkeilukirjandus / Kätlin Kaldmaa

    Index Scriptorium Estoniae

    Kaldmaa, Kätlin, 1970-

    2009-01-01

    Ülevaade 2008. aastal Eestis ilmunud tõlkeilukirjandusest. Pikemalt käsitletakse järgmisi autoreid ja nende teoseid: Margaret Atwood "Ebakõlad", William Faulkner "Absalom! Absalom!", Cormac McCarthy "Tee", Halldór Laxness "Islandi kell", T. H. White "Kunagine ja tulevane kuningas", Guillermo Martínez "Märkamatud mõrvad", Charlotte Weitze "Pimeduse pärusmaa", Daniel Kehlmann "Maailma mõõtmine", Milorad Pavić "Tuule sisemine pool, ehk, Romaan Herost ja Leandrosest", Michel Houellebecq "Elementaarosakesed", Marguerite Duras "Põhja-Hiina armuke", Haruki Murakami "Kafka mererannas", Anne Birkefeldt Radge "Berliini paplid", "Erakvähid" ja "Rohelised aasad", Linn Ullmann "Õnnistatud laps", Lars Saabye Christensen "Modell", Jon Fosse "See on Ales", Peter Høeg "Vaikne tüdruk", Leena Krohn "Matemaatilised olendid", Käbi Laretei "Kuhu kadus kõik see armastus?", E. M. Forster "Teekond Indiasse", Rudyard Kipling "Lispeth", Asha Miró ja Anna Soler-Pont "Sandlipuu jäljed", Khaled Hosseini "Lohejooksja", Billy Collins "Allegooria surm", Wisława Szymborska "Oma aja lapsed", Zbigniew Herbert "Valitud luuletused", Carlos Vitale "Kohaühtsus", Jüri Talvet (koostaja) "Ameerika luule antoloogia", Marjane Satrapi "Persepolis", Hergé "Sinine lootos" ja "Vaarao sigar", Sinikka Nopola "Risto Räppar ja kohutav vorst" ja "Risto Räppar ja viimane hoiatus", Espen Fyksen ja Øyvind Rune Stålen "Elias, väike päästekaater", Hannu Mäkelä "Miisa uus pere", Timo Parvela "Kiigelaud", Nick Hornby "Maoli", Pierre Bayard "Kuidas rääkida raamatutest, mida me pole lugenud", Milan Kundera "Eesriie", Georges Perec "Mõelda/liigitada ja teisi tekste"

  1. CRISPRpred: A flexible and efficient tool for sgRNAs on-target activity prediction in CRISPR/Cas9 systems.

    Directory of Open Access Journals (Sweden)

    Md Khaledur Rahman

    Full Text Available The CRISPR/Cas9-sgRNA system has recently become a popular tool for genome editing and a very hot topic in the field of medical research. In this system, Cas9 protein is directed to a desired location for gene engineering and cleaves target DNA sequence which is complementary to a 20-nucleotide guide sequence found within the sgRNA. A lot of experimental efforts, ranging from in vivo selection to in silico modeling, have been made for efficient designing of sgRNAs in CRISPR/Cas9 system. In this article, we present a novel tool, called CRISPRpred, for efficient in silico prediction of sgRNAs on-target activity which is based on the applications of Support Vector Machine (SVM model. To conduct experiments, we have used a benchmark dataset of 17 genes and 5310 guide sequences where there are only 20% true values. CRISPRpred achieves Area Under Receiver Operating Characteristics Curve (AUROC-Curve, Area Under Precision Recall Curve (AUPR-Curve and maximum Matthews Correlation Coefficient (MCC as 0.85, 0.56 and 0.48, respectively. Our tool shows approximately 5% improvement in AUPR-Curve and after analyzing all evaluation metrics, we find that CRISPRpred is better than the current state-of-the-art. CRISPRpred is enough flexible to extract relevant features and use them in a learning algorithm. The source code of our entire software with relevant dataset can be found in the following link: https://github.com/khaled-buet/CRISPRpred.

  2. Effects of a Combination Therapy of Sclerostin Antibody III and Raloxifene on Bone Formation Markers in Ovariectomized Rats

    International Nuclear Information System (INIS)

    Allam, H. I. G.

    2016-01-01

    Objective: To determine the systemic effect of sclerostin monoclonal antibody (Scl-AbIII) administration on markers of bone formation and compare it with a combination of sclerostin antibody and raloxifene. Study Design: Experimental study. Place and Duration of Study: Medical College Animal House at King Khaled University Hospital, Riyadh, Saudi Arabia, from January to November 2014. Methodology: Forty-five female rats were divided into 5 groups equally; 1 control group and 4 groups of ovariectomized (OVX) rats: control OVX rats and OVX rats treated by Scl-AbIII, raloxifene or Scl-AbIII+raloxifene one month after ovariectomy, continued for 4 weeks. At the end of treatment, serum levels of Bone Specific Alkaline Phosphatase (BSAP), alkaline phosphatase, osteocalcin, Insulin-like Growth Factor-1 (IGF-1), Parathyroid Hormone (PTH), Ca/sup 2+/ and phosphorus were measured. Uterus was weighed and body weight change was calculated. Results: Scl-AbIII or raloxifene treatment produced significant increase of serum BSAP, osteocalcin, IGF-1, PTH and Ca/sup 2+/ levels. Raloxifene, either alone or combined with Scl-AbIII attenuated the decrease in uterus wet weight, and the increase in body weight seen in OVX rats. Combination therapy of Scl-AbIII, and raloxifene produced significant increase of serum alkaline phosphatase, osteocalcin and IGF-1 levels than treatment with either Scl-AbIII or raloxifene alone. Conclusion: Combination therapy of Scl-AbIII and raloxifene is an attractive strategy to enhance bone formation and can offer better gain over treatment with either one of them alone. Confirmation of these preliminary observations must await careful long-term studies. (author)

  3. Psychiatric morbidity among Egyptian breast cancer patients and their partners and its impact on surgical decision-making

    Directory of Open Access Journals (Sweden)

    Abdel Wahab KM

    2012-03-01

    Full Text Available Mohamed A El-Hadidy1, Waleed Elnahas2, Mohamed AF Hegazy2, Mohamed T Hafez2, Basel Refky2, Khaled M Abdel Wahab21Department of Psychiatry, 2Department of Surgery, Mansoura Oncology Center, Mansoura University, Mansoura, EgyptIntroduction: Psychiatric morbidities, especially cases of anxiety and depression, are prevalent among breast cancer patients and their partners.Patients and methods: Fifty-four early diagnosed breast cancer patients and their partners were compared with 50 healthy couples to assess psychiatric morbidity and the impact of various factors upon patients' surgical choice.Results: It was found that 18.5%, 22.2%, and 3.7% of husbands had generalized anxiety disorder, major depressive disorder, and panic disorder, respectively. It was also found that 38.8%, 29.6%, and 9.2% of the patients had major depressive disorder, generalized anxiety disorder, and panic disorder, respectively. Depression and anxiety scores were high in both partners in love-based, well-adjusted marriages, within the middle socioeconomic class, and among educated couples. Among the well-known factors related to surgical treatment choice (age, parity, tumor size, pathology, grade, lymph node status, only age and psychological morbidity (in the patients and their partners had a significant impact on treatment choice.Conclusion: Patients of middle socioeconomic class, the well educated, and those in love-based marriages had a higher likelihood of suffering different types of psychological morbidities and were more likely to choose breast conservation or reconstruction than mastectomy.Keywords: anxiety, Arab, conservative, depression, mastectomy, reconstruction

  4. Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model

    Directory of Open Access Journals (Sweden)

    Parayath NN

    2016-08-01

    Full Text Available Neha N Parayath,1 Hayley Nehoff,1 Samuel E Norton,2 Andrew J Highton,2 Sebastien Taurin,1,3 Roslyn A Kemp,2 Khaled Greish1,4 1Department of Pharmacology and Toxicology, 2Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; 3Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA; 4Princess Al-Jawhara Centre for Molecular Medicine, Arabian Gulf University, Manama, Kingdom of Bahrain Abstract: Oral administration of paclitaxel (PTX, a broad spectrum anticancer agent, is challenged by its low uptake due to its poor bioavailability, efflux through P-glycoprotein, and gastrointestinal toxicity. We synthesized PTX nanomicelles using poly(styrene-co-maleic acid (SMA. Oral administration of SMA-PTX micelles doubled the maximum tolerated dose (60 mg/kg vs 30 mg/kg compared to the commercially available PTX formulation (PTX [Ebewe]. In a murine orthotopic colon cancer model, oral administration of SMA-PTX micelles at doses 30 mg/kg and 60 mg/kg reduced tumor weight by 54% and 69%, respectively, as compared to the control group, while no significant reduction in tumor weight was observed with 30 mg/kg of PTX (Ebewe. In addition, toxicity of PTX was largely reduced by its encapsulation into SMA. Furthermore, examination of the tumors demonstrated a decrease in the number of blood vessels. Thus, oral delivery of SMA-PTX micelles may provide a safe and effective strategy for the treatment of colon cancer. Keywords: oral delivery, anticancer nanomedicine, CT-26, enhanced permeability and retention (EPR effect, HUVEC, antiangiogenic

  5. Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity

    Directory of Open Access Journals (Sweden)

    Aljaeid BM

    2016-01-01

    Full Text Available Bader Mubarak Aljaeid,1 Khaled Mohamed Hosny1,2 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt Background and objective: Miconazole is a broad-spectrum antifungal drug that has poor aqueous solubility (<1 µg/mL; as a result, a reduction in its therapeutic efficacy has been reported. The aim of this study was to formulate and evaluate miconazole-loaded solid lipid nanoparticles (MN-SLNs for oral administration to find an innovative way to alleviate the disadvantages associated with commercially available capsules. Methods: MN-SLNs were prepared by hot homogenization/ultrasonication. The solubility of miconazole in different solid lipids was measured. The effect of process variables, such as surfactant types, homogenization and ultrasonication times, and the charge-inducing agent on the particle size, zeta potential, and encapsulation efficiency were determined. Furthermore, in vitro drug release, antifungal activity against Candida albicans, and in vivo pharmacokinetics were studied in rabbits. Results: The MN-SLN, consisting of 1.5% miconazole, 2% Precirol ATO5, 2.5% Cremophor RH40, 0.5% Lecinol, and 0.1% Dicetylphosphate, had an average diameter of 23 nm with a 90.2% entrapment efficiency. Furthermore, the formulation of MN-SLNs enhanced the antifungal activity compared with miconazole capsules. An in vivo pharmacokinetic study revealed that the bioavailability was enhanced by >2.5-fold. Conclusion: MN-SLN was more efficient in the treatment of candidiasis with enhanced oral bioavailability and could be a promising carrier for the oral delivery of miconazole. Keywords: miconazole, Precirol ATO5, solid lipid nanoparticles, encapsulation, Cremophor RH40, antifungal activity

  6. Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma

    Directory of Open Access Journals (Sweden)

    Kondkar AA

    2018-04-01

    Full Text Available Altaf A Kondkar, Tahira Sultan, Faisal A Almobarak, Hatem Kalantan, Saleh A Al-Obeidan, Khaled K Abu-Amero Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia Purpose: Retinal ganglion cell (RGC death is a key feature of glaucoma. Elevated levels of tumor necrosis factor alpha (TNF-α, a pro-inflammatory cytokine, can induce RGC apoptosis and play a critical role in glaucomatous neurodegeneration. Based on the possible role of inflammation and oxidative stress in the pathogenesis of primary open-angle glaucoma (POAG, we investigated the association between plasma levels of TNF-α and POAG or its clinical indices in comparison to non-glaucomatous controls. Patients and methods: In a case–control retrospective cohort of 51 POAG cases and 88 controls, plasma TNF-α levels were measured using an enzyme-linked immunosorbent assay (ELISA. The assay was performed in duplicates on an automated ELISA analyzer. Results: Mean TNF-α level was significantly elevated in POAG cases (1.88 ± 2.17 pg/mL than the controls (0.93 ± 1.49 pg/mL; p = 0.003. The overall dose–response trend was significant (Χ2 = 6.12, df = 2; p = 0.047. No statistical difference was seen in age, gender and systemic disease distribution. A modest negative and significant correlation was seen between TNF-α level and number of antiglaucoma medications, an important clinical index of POAG severity. Moreover, logistic regression analysis showed that the risk of POAG was most significantly affected by TNF-α level and not by age and sex. Conclusion: High systemic level of an inflammatory cytokine, TNF-α, is associated with POAG; however, its possible use as a biomarker for early glaucoma diagnosis and/or disease severity needs further investigation. Keywords: apoptosis, biomarker, cytokines, ELISA, inflammation, neurodegeneration, oxidative stress

  7. Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus

    Directory of Open Access Journals (Sweden)

    Mofty H

    2017-11-01

    Full Text Available Hanan Mofty,1,2 Khaled Alzahrani,2 Fiona Carley,3 Sophie Harper,3 Arun Brahma,3 Leon Au,3 Debbie Morley,3 M Chantal Hillarby2 1Optometry Department, College of Applied Medical Science, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3Manchester Royal Eye Hospital, Manchester, UK Purpose: The purpose of this study was to assess UV corneal crosslinking (CXL treatment outcomes for keratoconus by evaluating the corneal regularity in patients through follow-up using the Oculus Pentacam.Patients and methods: A total of 18 eyes from CXL patients with keratoconus were studied before and after CXL treatment, and six eyes from six patients who were not treated with CXL served as controls. Treated patients had Pentacam images taken before CXL treatment and regularly 3 months post treatment up to the 12th month. Controls were imaged during their first appointment and after 12 months. Symmetry and asphericity were evaluated and correlated with both best-corrected visual acuity (BCVA and maximum K-readings.Results: In the CXL-treated group, there was a significant improvement in the index of symmetrical variation (ISV and keratoconus index (KI at 3 months and in the index of height asymmetry (IHA and minimum radius of curvature (Rmin at 9 months post treatment. On the contrary, the untreated group’s indices showed some significant worsening in ISV, KI, central keratoconus index (CKI, and Rmin. A novel finding in our study was a slight positive shift of anterior asphericity in the 6 mm, 7 mm, and 8 mm 3 months after treatment, which had a correlation with BCVA (R2=0.390, p=0.053 and a strong correlation with maximum K-reading (R2=0.690, p=0.005. However, the untreated group had no significant changes after 1 year.Conclusion: The corneal asymmetrical shape is associated with the spherical aberration alteration

  8. Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites

    Directory of Open Access Journals (Sweden)

    Habiba K

    2015-12-01

    Full Text Available Khaled Habiba,1,2 Joel Encarnacion-Rosado,2,3 Kenny Garcia-Pabon,2,4 Juan C Villalobos-Santos,2,5 Vladimir I Makarov,1 Javier A Avalos,2,6 Brad R Weiner,2,7,8 Gerardo Morell1,2,7 1Department of Physics, University of Puerto Rico – Rio Piedras Campus, 2Molecular Sciences Research Center, University of Puerto Rico, 3Department of Biology, 4Faculty of Education, University of Puerto Rico – Rio Piedras Campus, San Juan, 5Department of Biology, 6Department of Physics, University of Puerto Rico – Bayamon Campus, Bayamon, 7Institute for Functional Nanomaterials, University of Puerto Rico, 8Department of Chemistry, University of Puerto Rico – Rio Piedras Campus, San Juan, PR, USA Abstract: The combination of chemotherapy and photodynamic therapy has emerged as a promising strategy for cancer therapy due to its synergistic effects. In this work, PEGylated silver nanoparticles decorated with graphene quantum dots (Ag-GQDs were tested as a platform to deliver a chemotherapy drug and a photosensitizer, simultaneously, in chemo-photodynamic therapy against HeLa and DU145 cancer cells in vitro. Ag-GQDs have displayed high efficiency in delivering doxorubicin as a model chemotherapy drug to both cancer cells. The Ag-GQDs exhibited a strong antitumor activity by inducing apoptosis in cancer cells without affecting the viability of normal cells. Moreover, the Ag-GQDs exhibited a cytotoxic effect due to the generation of the reactive singlet oxygen upon 425 nm irradiation, indicating their applicability in photodynamic therapy. In comparison with chemo or photodynamic treatment alone, the combined treatment of Ag-GQDs conjugated with doxorubicin under irradiation with a 425 nm lamp significantly increased the death in DU145 and HeLa. This study suggests Ag-GQDs as a multifunctional and efficient therapeutic system for chemo-photodynamic modalities in cancer therapy. Keywords: multifunctional nanoparticles, silver nanoparticles, cancer therapy, drug

  9. Consumer Adoption of Personal Health Record Systems: A Self-Determination Theory Perspective.

    Science.gov (United States)

    Assadi, Vahid; Hassanein, Khaled

    2017-07-27

    for designing, promoting, and facilitating the use of PHR systems among consumers. ©Vahid Assadi, Khaled Hassanein. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 27.07.2017.

  10. Efficacy and safety of cross-linked hyaluronic acid single injection on osteoarthritis of the knee: a post-marketing phase IV study

    Directory of Open Access Journals (Sweden)

    Bashaireh K

    2015-04-01

    Full Text Available Khaldoon Bashaireh,1 Ziad Naser,2 Khaled Al Hawadya,2 Sorour Sorour,2 Rami Nabeel Al-Khateeb3 1Department of Orthopedics Surgery, King Abdullah University Hospital, Jordan University of Science and Technology, Irbid, Jordan; 2Private Clinic, 3Elaf Medical Supplies Company, Amman, Jordan Purpose: The primary objective of this study was to evaluate the efficacy, safety, and duration of action of viscosupplementation with Crespine® Gel over a 9-month period.Materials and methods: The study was a post-marketing phase IV study. A total of 109 participants with osteoarthritis of the knee (grades 1–4 in the tibio–femoral compartment were recruited in Jordan. Data were collected from each participant during the baseline visit. Each participant received Crespine® Gel injection, and follow-up visits took place at 3 months, 6 months, and 9 months post-injection.Main outcome measure(s: An assessment of participants by phone was conducted at 1 month, 2 months, 4 months, 5 months, 7 months, and 8 months post-injection. Western Ontario and McMaster Universities Arthritis Index questionnaires were completed during each visit. A 72-hour visit questionnaire was used to assess the safety of the injection. Statistical analysis included a two-sided 95% confidence interval for the difference between pain scores across visits, and the percent change from baseline was calculated.Main results: The full analysis included 84 participants who gave their informed consent and finished the necessary baseline and follow-up visits needed to assess efficacy and safety. Peak improvement was noted at 5 months post-injection, when pain and physical performance scores had decreased to 2.60 and 9.90, respectively, and the stiffness score was 0.33. The peak improvement in stiffness was noted at 8 months post-injection, when the stiffness score had decreased to 0.32. Significant improvements were still apparent at 9 months post-injection, when the pain score was 3

  11. Depot injectable biodegradable nanoparticles loaded with recombinant human bone morphogenetic protein-2: preparation, characterization, and in vivo evaluation

    Directory of Open Access Journals (Sweden)

    Hassan AH

    2015-07-01

    Full Text Available Ali Habiballah Hassan,1 Khaled Mohamed Hosny,2,3 Zuahir A Murshid,1 Adel Alhadlaq,4 Ahmed Alyamani,5 Ghada Naguib6 1Department of Orthodontics, Faculty of Dentistry, 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt; 4Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, 5Department of Oral Surgery, 6Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia Objective: The aim of this study is to utilize the biocompatibility characteristics of biodegradable polymers, viz, poly lactide-co-glycolide (PLGA and polycaprolactone (PCL, to prepare sustained-release injectable nanoparticles (NPs of bone morphogenetic protein-2 (BMP-2 for the repair of alveolar bone defects in rabbits. The influence of formulation parameters on the functional characteristics of the prepared NPs was studied to develop a new noninvasive injectable recombinant human BMP-2 (rhBMP-2 containing grafting material for the repair of alveolar bone clefts.Materials and methods: BMP-2 NPs were prepared using a water-in-oil-in-water double-emulsion solvent evaporation/extraction method. The influence of molar ratio of PLGA to PCL on a suitable particle size, encapsulation efficiency, and sustained drug release was studied. Critical size alveolar defects were created in the maxilla of 24 New Zealand rabbits divided into three groups, one of them treated with 5 µg/kg of rhBMP-2 NP formulations.Results: The results found that NPs formula prepared using blend of PLGA and PCL in 4:2 (w/w ratio showed the best sustained-release pattern with lower initial burst, and showed up to 62.7% yield, 64.5% encapsulation efficiency, 127 nm size, and more than 90% in vitro release. So, this formula was selected for

  12. Suicidal and self-injurious behavior among patients with alcohol and drug abuse

    Directory of Open Access Journals (Sweden)

    Al-Sharqi AM

    2012-07-01

    Full Text Available Abdullah Mohammed Al-Sharqi,1 Khaled Saad Sherra,2 Abdulhameed Abdullah Al-Habeeb,3 Naseem Akhtar Qureshi3,41Private Clinic, Riyadh, Saudi Arabia; 2Psychiatric Department, Faculty of Medicine, Mansoura University, Egypt; 3General Administration for Mental Health and Social Services, 4General Directorate of Research and Studies, Ministry of Health, Riyadh, Saudi ArabiaBackground: Self-injurious behavior, a major public health problem globally, is linked with alcohol and drug abuse. This cross-sectional study aimed to identify the prevalence and correlates of self-harming behavior in patients with alcohol or drug abuse problems.Methods: This was a one-year study that recruited a convenience sample of 736 outpatients and inpatients identified with alcohol or drug abuse, and was conducted at Al-Amal mental health hospitals in three major cities. All consecutively selected patients were interviewed on five working days for data collection on a semistructured sociodemographic form using the Columbia Suicide Severity Rating Scale Risk Assessment version.Results: In addition to the socioclinical profile revealed, 50.7% of respondents reported any suicidal ideation, while 6.9% reported self-injurious behavior without intent to die. Any suicidal and self-injurious behavior was reported by 13.1% of participants. A total of 71.3% of respondents reported any recent negative activating events. In addition to any treatment history, observed correlates were hopelessness (60.7%, perceived burden on family (29.5%, refusing a safety plan (26.1%, and sexual abuse (11%. Conversely, reasons for living (64.9%, fear of death or dying due to pain and suffering (64.3%, and spirituality (92% were largely endorsed as protective factors. There were multiple significant odds ratios (P ≤ 0.01 revealed when independent socioclinical variables were compared with dependent variables in terms of suspected risk and protective factors. In an adjusted logistic regression model

  13. Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics

    Directory of Open Access Journals (Sweden)

    Ahmed OA

    2015-01-01

    Full Text Available Osama AA Ahmed,1,2 Khaled M Hosny,1,3 Majid M Al-Sawahli,1,4 Usama A Fahmy11Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Minia University, Minia, Egypt; 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt; 4Holding Company for Biological Products & Vaccines (VACSERA, Cairo, EgyptAbstract: The current study focuses on utilization of the natural biocompatible polymer zein to formulate simvastatin (SMV nanoparticles coated with caseinate, to improve solubility and hence bioavailability, and in addition, to modify SMV-release characteristics. This formulation can be utilized for oral or possible depot parenteral applications. Fifteen formulations were prepared by liquid–liquid phase separation method, according to the Box–Behnken design, to optimize formulation variables. Sodium caseinate was used as an electrosteric stabilizer. The factors studied were: percentage of SMV in the SMV-zein mixture (X1, ethanol concentration (X2, and caseinate concentration (X3. The selected dependent variables were mean particle size (Y1, SMV encapsulation efficiency (Y2, and cumulative percentage of drug permeated after 1 hour (Y3. The diffusion of SMV from the prepared nanoparticles specified by the design was carried out using an automated Franz diffusion cell apparatus. The optimized SMV-zein formula was investigated for in vivo pharmacokinetic parameters compared with an oral SMV suspension. The optimized nanosized SMV-zein formula showed a 131 nm mean particle size and 89% encapsulation efficiency. In vitro permeation studies displayed delayed permeation characteristics, with about 42% and 85% of SMV cumulative amount released after 12 and 48 hours, respectively. Bioavailability estimation in rats revealed an augmentation in SMV bioavailability

  14. Spontaneous release of epiretinal membrane in a young weight-lifting athlete by presumed central rupture and centrifugal pull

    Directory of Open Access Journals (Sweden)

    Mansour AM

    2014-11-01

    Full Text Available Ahmad M Mansour,1,2 Hana A Mansour,3 J Fernando Arevalo4,5 1Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon; 2Department of Ophthalmology, American University of Beirut, Beirut, Lebanon; 3Department of Biology, American University of Beirut, Beirut, Lebanon; 4Retina Department, The King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 5Retina Department, Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD, USA Abstract: This patient presented for surgery at the age of 32 years, 14 months after his initial complaint of metamorphopsia and visual loss in the right eye. Past tests demonstrated a whitish epiretinal membrane (ERM with translucent stress lines over a thickened macula. Visual acuity was found on last presentation to be normal with minimal alteration on Amsler grid testing. A torn ERM was found in the center with left-over ERM temporally and rolled-over ERM nasally at the site of the epicenter with no posterior vitreous detachment. Visual recovery occurred gradually over several days 2 months prior to presentation apparently following heavy weight-lifting with a sensation of severe eye pressure. Sequential funduscopy and optical coherence tomography scans demonstrated the peeling of an ERM accompanied by normalization of foveal thickness. Valsalva maneuver had put excessive tension on ERM which tore in its center at the weakest line with gradual contraction of the ERM away from the fovea towards the peripapillary area. This is a new mechanism of self-separation of ERM induced by Valsalva. ERM in young subjects is subject to rupture and subsequent separation by tangential traction. There are three mechanisms for spontaneous separation of ERM: 1 posterior vitreous detachment with pulling of ERM by detaching vitreous (most common in adults; 2 the contracting forces of the immature ERM become stronger than its adhesions to the retina resulting in slow tangential traction on the

  15. Celiac disease in children: is it a problem in Kuwait?

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    Al-Qabandi W

    2014-12-01

    Full Text Available Wafa'a Al-Qabandi,1 Eman Buhamrah,2 Dalia Al-Abdulrazzaq,1 Khaled Hamadi,2 Fawaz Al Refaee3 1Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait; 2Department of Pediatrics, Al Amiri Hospital, Kuwait; 3Department of Pediatrics, Al Adan Hospital, Kuwait  All authors contributed equally to the study Background: Celiac disease (CD is a chronic inflammatory disease of the small intestine triggered by gluten ingestion. The objective of this study is to describe our experience with CD children in Kuwait. Methods: The records of children with CD seen in the pediatric gastroenterology unit between February 1998 and December 2010 were retrospectively reviewed. Patients were referred because of symptoms or positive CD antibody screening of a high-risk group (type 1 diabetes and Down syndrome. Results: Forty-seven patients were diagnosed: 53% were symptomatic and 47% were identified by screening. The median age at diagnosis was 66 (range 7–189 months. All cases were biopsy-proven except one. The symptomatic patients were significantly younger than those identified following screening (P<0.004. In the whole group, 66% were females and 77% were Kuwaitis; 9% had a positive family history of CD. The estimated cumulative incidence was 6.9/105. The median duration of symptoms before diagnosis was 8.5 (range 2–54 months. Failure to thrive was the most common presenting complaint (72% followed by diarrhea (64% and abdominal distension (56%. Atypical manifestations were seen in 60% of patients. Underweight and short stature were confirmed in 19% and 17% of patients, respectively. Overweight and obesity were detected in 14% and 6%, respectively. CD serology was based on a combination of antiendomysial and antigliadin antibodies. The median follow up was 24 (range 12–144 months. All patients were commenced on a gluten free diet, but good compliance was only achieved in 78%. Conclusion: The low frequency of childhood CD in Kuwait could

  16. Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

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    Ahmed TA

    2016-01-01

    Full Text Available Tarek A Ahmed,1,2 Yasser A Alharby,1 Abdel-Rahim M El-Helw,1 Khaled M Hosny,1,3 Khalid M El-Say1,21Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt; 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, EgyptAbstract: This study aimed to develop an optimized depot injectable atorvastatin (ATR biodegradable in situ gel (ISG system with minimum initial burst using a central composite design. The factors selected were poly (D, L-lactide-co-glycolide (PLGA concentration (X1, molecular weight of polyethylene glycol (PEG (X2, and PEG concentration (X3. The independent variables were the initial burst of ATR after 2 (Y1 and 24 hours (Y2. The optimized formulation was investigated using scanning electron microscopy, Fourier transform infrared spectroscopy, and in vitro drug release in phosphate-buffered saline of pH 7.4 for 72 hours. The in vivo pharmacokinetic study of the optimized ATR-ISG and the corresponding PEG-free ATR-ISG were conducted by intramuscular injection of a single dose (2 mg/kg of ATR in male New Zealand White rabbits. A double-blind, randomized, parallel design was used in comparison with those of the marketed ATR tablet. Statistical analysis revealed that PLGA concentration and the molecular weight of PEG have pronounced effects on both Y1 and Y2. The optimized formulation was composed of 36.10% PLGA, PEG 6000, and 15.69% PEG, and exhibited characteristic in vitro release pattern with minimal initial burst. Incorporation of PEG in the formulation causes a slight decrease in the glass transition temperature value of PLGA, leading to a slight change in Fourier transform infrared spectroscopy spectrum due to possible interaction. Moreover, scanning electron microscopy photomicrograph showed smooth

  17. Intravenous patient-controlled fentanyl with and without transversus abdominis plane block in cirrhotic patients post liver resection

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    Serag Eldin M

    2014-05-01

    Full Text Available Manar Serag Eldin,1 Fatma Mahmoud,1 Rabab El Hassan,2 Mohamed Abdel Raouf,1 Mohamed H Afifi,2 Khaled Yassen,1 Wesam Morad31Department of Anaesthesia, Liver Institute, 2Department of Anaesthesia, Faculty of Medicine, 3Department of Community Medicine and Public Health, Liver Institute, Menoufiya University, Shebin El-Kom, EgyptBackground: Coagulation changes can complicate liver resection, particularly in patients with cirrhosis. The aim of this prospective hospital-based comparative study was to compare the postoperative analgesic efficacy of intravenous fentanyl patient-controlled analgesia (IVPCA with and without transversus abdominis plane (TAP block.Methods: Fifty patients with Child’s A cirrhosis undergoing liver resection were randomly divided into two groups for postoperative analgesia, ie, an IVPCA group receiving a 10 µg/mL fentanyl bolus of 15 µg with a 10-minute lockout and a maximum hourly dose of 90 µg, and an IVPCA + TAP group that additionally received TAP block (15 mL of 0.375% bupivacaine on both sides via a posterior approach with ultrasound guidance before skin incision. Postoperatively, bolus injections of bupivacaine 0.375% were given every 8 hours through a TAP catheter inserted by the surgeon in the open space during closure of the inverted L-shaped right subcostal with midline extension (subcostal approach guided by the visual analog scale score (<3, 5 mL; 3 to <6, 10 mL; 6–10, 15–20 mL according to weight (maximum 2 mg/kg. The top-up dosage of local anesthetic could be omitted if the patient was not in pain. Coagulation was monitored using standard coagulation tests.Results: Age, weight, and sex were comparable between the groups (P<0.05. The visual analog scale score was significantly lower at 12, 18, 24, 48, and 72 hours (P<0.01 in IVPCA + TAP group. The Ramsay sedation score was lower only after 72 hours in the IVPCA + TAP group when compared with the IVPCA group (1.57±0.74 versus 2.2±0.41, respectively, P

  18. تمثلات المثاليـة في نصوص مثال غازي المسرحية

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    اشكان حسين غالي

    2017-03-01

    writers who included Msarhyatem the ideal concepts and demonstrated at the level of (personal, language, dialogue, idea. The third and final section has included references to the writer cognitive Ghazi example, which played a role in the writing of the play texts. The concluding chapter indicators resulting from the theoretical framework and previous studies. And devoted Chapter III of the research procedures, which included the identification of a society, which included four plays, and the research sample and method in which the researcher adopted the descriptive approach (analytical being in line with the nature of the research and his goal, and search tool which the researcher relied on indicators resulting from the theoretical framework as an analytical standards and, finally, the research sample analysis. The search is over fourth quarter in which the researcher has left a number of results, including: 1-\tidealistic philosophy recognizes the existence of another world absolute Khaled independently of a man of God and industry which can be absorbed through the mind. Researcher concluded a number of conclusions, including the following: 2.\tJustice and goodness and morality are the features that distinguish from which to perfect things.

  19. Stigma associated with mental illness: perspectives of university students in Qatar

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    Zolezzi M

    2017-05-01

    Full Text Available Monica Zolezzi,1,2 Nawal Bensmail,2 Farah Zahrah,2 Salma Mawfek Khaled,3 Tayseer El-Gaili4 1Clinical Pharmacy and Practice, 2College of Pharmacy, 3Research Unit, Social and Economic Survey Research Institute, 4Student Counseling Center, Qatar University, Doha, Qatar Background: Stigma in relation to mental illness is one of the main factors inhibiting people from seeking help. Studies have been undertaken looking into the knowledge, attitudes, and beliefs (KAB about mental illness among residents in Qatar; however, none have looked specifically at students in higher education. The aim of this study was to understand the KAB toward mental illness among students at a Qatari university and determine if there are any differences based on gender, nationality, and college type. Methods: A convenience sample of students from all genders, colleges, and nationalities was approached to participate in a survey that consisted of four sections: demographic, beliefs, attitudes, and help-seeking and treatment preferences associated with mental illness. Chi-square testing was performed to test for differences in the distribution of proportions of our primary outcomes (students’ beliefs, attitudes, and help-seeking and treatment preferences. Results: A total of 282 students completed the survey. The majority of the participating students were females (59.3%, non-Qataris (64.3%, and enrolled in science-based colleges (62.7%. Beliefs reflecting poor mental health literacy, such as “medications to treat mental illness can cause addiction”, “mental illness is not like any other illness”, or that “mental illness is a punishment from God”, were reported by a majority of students (84.4%, 56.7%, and 50.2%, respectively. Stigmatizing attitudes that were endorsed by a majority of students included believing that people with mental illness cannot have regular jobs (60.2%, that people with mental illness are dangerous (65.7%, and that they would not marry

  20. Gamification in Fostering Creativity

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    Marius Kalinauskas

    2014-10-01

    Full Text Available Purpose – to analyze gamification, as the method for fostering creativity.Design/methodology/approach – Author analyses the precognitions, which allowed gamification to attract mainstream attention, the diversity of understandings about the phenomenon, and the possible relations between usage of gamified platform and the development of creativity. The paper is based on the comparative analysis of scientific literature and related sources from sociology, business, and entertainment. The engagement is analyzed through the theories of self-determination and the “flow”. Creativity is understood as “any act, idea, or product that changes an existing domain, or that transforms an existing domain into a new one” (Csikszentmihalyi, 1996. Gamification is analyzed as “use of game design elements in non-game context” (Deterding, Dixon, Khaled, and Nacke (2011. Findings – Although the gamification is gaining more public attention, there is a lack of studies which would reveal its relations in fostering creativity. One of the main goals of any gamified platform is to raise the engagement of the participant while keeping subject interested in the process or activity. In some cases, there is a relation between “flow” and creativity. However, the strength of this relationship depends from the users of gamified content and the domain of interest.Research limitations / implications – There are very few empirical studies which would support correlation between experiencing the “flow” state and a raise of creativity. This issue requires more surveys, which would ground the idea.Practical implications – By developing further research in usage of gamification while fostering creativity it is possible to determine, whether or not the “creative domains” should apply more measures of gamification in their activities.Value – The article emphasizes on theoretical analysis of gamification and its applicability in fostering creativity

  1. Deep brain stimulation targeting the fornix for mild Alzheimer dementia: design of the ADvance randomized controlled trial

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    Holroyd KB

    2015-07-01

    Full Text Available Kathryn B Holroyd,1 Lisa Fosdick,2 Gwenn S Smith,1 Jeannie-Marie Leoutsakos,1 Cynthia A Munro,1 Esther S Oh,1 Kristen E Drake,2 Paul B Rosenberg,1 William S Anderson,1 Stephen Salloway,3–5 J Cara Pendergrass,6 Anna D Burke,7 David A Wolk,8 David F Tang-Wai,9–11 Francisco A Ponce,12 Wael F Asaad,13,14 Marwan N Sabbagh,15 Michael S Okun,16 Gordon Baltuch,17 Kelly D Foote,18 Steven D Targum,2,6 Andres M Lozano,10,11 Constantine G Lyketsos1 1Johns Hopkins University Memory and Alzheimer's Treatment Center, Baltimore, MD, 2Functional Neuromodulation Ltd, Minneapolis, MN, 3Department of Neurology, Butler Hospital, 4Department of Neurology, Rhode Island Hospital, 5Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, 6Clintara LLC, Boston, MA, 7Banner Alzheimer's Institute, Phoenix, AZ, 8Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; 9Department of Neurology, 10Department of Neurosurgery, University of Toronto, 11Division of Neurology, University Health Network Memory Clinic, Toronto, ON, Canada; 12Division of Neurological Surgery, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, 13Department of Neurosurgery, Rhode Island Hospital, 14Department of Neurosurgery, Warren Alpert Medical School of Brown University, Providence, RI, 15Banner Sun Health Research Institute, Sun City, AZ, 16Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida – Gainsville, Gainsville, FL, 17Center for Functional and Restorative Neurosurgery, University of Pennsylvania, Philadelphia, PA, 18Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainsville, FL, USA Background: There are currently few available treatments and no cure for Alzheimer disease (AD, a growing public health burden. Animal models and an open-label human trial have indicated that deep brain

  2. Editorial

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    AHM Zahirul Alam

    2018-06-01

    is made by the publisher and editorial board to see that no inaccurate or misleading data, opinion or statement appears in this Journal, they wish to make it clear that the data and opinions appearing in the articles and advertisement herein are the responsibility of the contributor or advertiser concerned. Accordingly, the publisher and the editorial committee accept no liability whatsoever for the consequence of any such inaccurate or misleading data, opinion or statement.      IIUM Engineering Journal ISSN: 1511-788X   E-ISSN: 2289-7860   Volume 19, Issue 1, June 2018 https://doi.org/10.31436/iiumej.v19i1 Table of Content     CHEMICAL AND BIOTECHNOLOGY ENGINEERING ADSORPTION OF HEAVY METALS AND RESIDUAL OIL FROM PALM OIL MILL EFFLUENT USING A NOVEL ADSORBENT OF ALGINATE AND MANGROVE COMPOSITE BEADS COATED WITH CHITOSAN IN A PACKED BED COLUMN... 1 Rana Jaafar Jawad, Mohd Halim Shah Ismail, Shamsul Izhar Siajam INVESTIGATION OF BIOFLOCCULANT AS DEWATERING AID IN SLUDGE TREATMENT........................................ 15 Mohammed Saedi Jami, Maizirwan Mel, Aysha Ralliya Mohd Ariff, Qabas Marwan Abdulazeez HYDROGEN PRODUCTION FROM ETHANOL DRY REFORMING OVER LANTHANIA-PROMOTED CO/AL2O3 CATALYST............................. 24 Fahim Fayaz, Nguyen Thi Anh Nga, Thong Le Minh Pham, Huong Thi Danh, Bawadi Abdullah, Herma Dina Setiabudi, Dai-Viet Nguyen Vo OPTIMIZATION OF RED PIGMENT PRODUCTION BY MONASCUS PURPUREUS FTC 5356 USING RESPONSE SURFACE METHODOLOGY......................................................... 34 Nor Farhana Hamid And Farhan Mohd Said PRODUCTION AND STABILITY OF MYCO-FLOCCULANTS FROM LENTINUS SQUARROSULUS RWF5 AND SIMPLICILLIUM OBCLAVATUM RWF6 FOR REDUCTION OF WATER TURBIDITY.............................................................................. 48 Nessa Jebun, Md. Zahangir Alam, Abdullah Al-Mamun, Raha Ahmad Raus ROLE OF SUBSTRATE BINDING ON THE PROTEIN DYNAMICS OF AN ENDOGLUCANASE FROM FUSARIUM OXYSPORUM AT DIFFERENT TEMPERATURES

  3. BOOK REVIEW: Case Studies in Knowledge Management

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    Reviewed by Dr. Adnan BOYACI

    2005-10-01

    .The book presents case studies explaining actual applications of KM in a different oforganizational and global settings. Different subjects and issues associated withconstruction of KM system in different kinds of organizations are explored within eachsection. Organizational learning (OL, knowledge, culture and productivity are some ofthe issues tackled with construction of KM system in a variety of organizational andglobal settings.The book is organized into seven sections; KM in support of organizational learning,knowledge management in support of retaining organizational knowledge, knowledgemanagement strategy, issues in knowledge management, KM is support of knowledgetransfer, KM in support of projects, KM outcomes. Each section is related with an area KMresearch.In section I, there are two cases discussing KM in support of OL. The first case is fromLynne P. Cooper, Rebecca L. Nash, Tu-Anh T. Phan, and Teresa R. Bailey and describesdevelopment and operation of knowledge system in order to support learning oforganizational knowledge at the Jet Propulsion Laboratory in USA. It presents in detailimplementation and rollout of the system and argues the results from performance andusage data collected over 19 weeks. The second case is from Brigette McGregor-MacDonald and describes the work of global organizations in its KM efforts to sustain andtransfer learning from global leadership curriculum. It mainly focuses on KM solution162developed to support employees to sustain their learning, to enable them to share theirinsights and experiences with others, and thus increase organizational capability.Section 2 explores using KM to support the retention of organizational knowledge inorganizations where the work forces are in transition. In third chapter in this section HaniAbdel-Aziz, and Khaled Wahba discuss the building of organizational memory informationsystem (OMIS in an Egyptian Professional Services company suffering from knowledgeloss due to high rate of employee turnover

  4. List of Participants

    Science.gov (United States)

    2008-11-01

    MoralIstituto Nazionale di Fisica Nucleare, Università di Torino Valentina Giangreco Marotta PulettiUppsala University Valeria L GiliQueen Mary, University of London Luciano GirardelloUniversità di Milano-Bicocca Gian GiudiceCERN, Geneva Kevin Goldstein Institute for Theoretical Physics, Utrecht University Joaquim Gomis Universitat de Barcelona Pietro Antonio GrassiUniversità del Piemonte Orientale, Alessandria Viviane GraßLudwig-Maximilians-Universität, München Gianluca Grignani Università di Perugia Luca Griguolo Università di Parma Johannes GrosseJagiellonian University, Krakow Umut Gursoy École Polytechnique, Palaiseau Norberto Gutierrez RodriguezUniversity of Oviedo Babak HaghighatPhysikalisches Institut, Universität Bonn Troels Harmark Niels Bohr Institute, København Robert HaslhoferEidgenössische Technische Hochschule (ETH), Zürich Tae-Won HaPhysikalisches Institut, Universität Bonn Alexander HauptImperial College London and Max-Planck-Institut für Gravitationsphysik (AEI), Potsdam Marc HenneauxUniversité Libre de Bruxelles Johannes HennLAPTH, Annecy-le-Vieux Shinji HiranoNiels Bohr Institute, København Stefan HoheneggerEidgenössische Technische Hochschule (ETH), Zürich Jan HomannLudwig-Maximilians-Universität, München Gabriele Honecker CERN, Geneva Joost HoogeveenInstituut voor Theoretische Fysica, Universiteit van Amsterdam Mechthild HuebscherUniversidad Autónoma de Madrid Chris HullImperial College London Carmen-Liliana IonescuUniversity of Craiova Ella JasminUniversité Libre de Bruxelles Konstantin KanishchevInstitute of Theoretical Physics, University of Warsaw Stefanos Katmadas Utrecht University Alexandros KehagiasNational Technical University of Athens Christoph Keller Eidgenössische Technische Hochschule (ETH), Zürich Patrick Kerner Max-Planck-Institut für Physik, München Rebiai KhaledLaboratoire de Physique Mathématique et Physique Subatomique, Université Mentouri, Constantine Elias Kiritsis Centre de Physique Théorique,

  5. 6th International Symposium on Molecular Allergology (ISMA

    Directory of Open Access Journals (Sweden)

    Christiane Hilger

    2016-10-01

    depletion approach to access IgE cross-reactivity Diana Silva, Teresa Vieira, Ana Maria Pereira, André Moreira, Luís Delgado P54 Olive pollen allergens: what are we missing? Sara Prates, Cátia Alves, Elena Finelli, Paula Leiria Pinto P55 Purified Alt a 1 extract in Alternaria alternata allergy diagnosis Bárbara Kong Cardoso, Cíntia Cruz, Filipa Semedo, Elza Tomaz, Filipe Inácio P56 Use of specific IgE Bos d8 (casein to aid early introduction of dietary baked milk in children with cows’ milk allergy James Gardner, Santanu Maity, Giuseppina Rotiroti, Minal Gandhi P57 Molecular characterisation and immunoreactivity of a peanut ingredient for use in oral food challenges Ivona Baricevic-Jones, Justin T. Marsh, Phil E. Johnson, Anuradha Balasundaram, Anya-May Hope, Aafke Taekema, Angela Simpson, Aida Semic-Jusufagic, E.N. Clare Mills P58 Specific IgE to recombinant allergens of hazelnut and oral food challenge in children Gourdon Dubois Nelly, Sellam Laetitia, Pereira Bruno, Michaud Elodie, Messaoudi Khaled, Evrard Bertrand, Fauquert Jean-Luc Poster session 7/8: miscellaneous P59 What defines a protein as an allergen? A discussion of sources and sufficiency Richard E. Goodman P60 Cat allergy: relationship between clinical and molecular diagnostic María Cecilia Martín Fernández De Basoa, Antón Fernández Ferreiro, Elena Rodríguez Plata P61 Anaphylaxis to rabbit: the cat came in last Luis Amaral, Borja Bartolomé, Alice Coimbra, Jose L Placido P62 Dog allergy: relationship between clinical and molecular diagnostic María Cecilia Martín Fernández De Basoa, Antón Fernández Ferreiro, Elena Rodríguez Plata P63 Correlation of serum timothy grass-pollen specific IgE levels determined by two immunoblot test systems Mariana Vieru, Florin-Dan Popescu, Florin-Adrian Secureanu, Carmen Saviana Ganea P64 Development of oral food challenge formulations for diagnosis of fish allergy using powdered fish ingredients Carol Ann Costello, Ivona Baricevic-Jones, Martin Sorensen, Clare