[Illustrations of of alchemy vessels in a manuscript of Pseudo-Geber].

Science.gov (United States)

Kurzmann, Peter

2011-01-01

Manuscript ric. 933 "Geber de investigatione perfectionis magisterii", kept in the Libreria Riccardiana in Florence, is a 13th century Latin version of the "Book of the Secret of the Secrets" ("kitab sirr al-asrar") by the Arabian alchemist al-Razi (865-925). The manuscript shows on page 25r a series of drawings of alchemistic vessels and apparatus which do not figure in the Arabian original but which are of particular interest as they date from as early as the 13th century and are numbered amongst the earliest drawings of this kind which we possess. The publication of the manuscript by Julius Ruska in 1935 shows only copied drawings with his interpretations of the legends. There was considerable interest in the publication of the original page 25r and in the course of further study it became clear that these interpretations had to be revised. These new interpretations presented in detail in this paper are justified and put into an alchemistic context. In some cases they give a new understanding and differ considerably from Ruska's versions.

Validation of the AMSU-B Bias Corrections Based on Satellite Measurements from SSM/T-2

Science.gov (United States)

Kolodner, Marc A.

1999-01-01

The NOAA-15 Advanced Microwave Sounding Unit-B (AMSU-B) was designed in the same spirit as the Special Sensor Microwave Water Vapor Profiler (SSM/T-2) on board the DMSP F11-14 satellites, to perform remote sensing of spatial and temporal variations in mid and upper troposphere humidity. While the SSM/T-2 instruments have a 48 km spatial resolution at nadir and 28 beam positions per scan, AMSU-B provides an improvement with a 16 km spatial resolution at nadir and 90 beam positions per scan. The AMSU-B instrument, though, has been experiencing radio frequency interference (RFI) contamination from the NOAA-15 transmitters whose effect is dependent upon channel, geographic location, and current spacecraft antenna configuration. This has lead to large cross-track biases reaching as high as 100 Kelvin for channel 17 (150 GHz) and 50 Kelvin for channel 19 (183 +/-3 GHz). NOAA-NESDIS has recently provided a series of bias corrections for AMSU-B data starting from March, 1999. These corrections are available for each of the five channels, for every third field of view, and for three cycles within an eight second period. There is also a quality indicator in each data record to indicate whether or not the bias corrections should be applied. As a precursor to performing retrievals of mid and upper troposphere humidity, a validation study is performed by statistically analyzing the differences between the F14 SSM/T-2 and the bias corrected AMSU-B brightness temperatures for three months in the spring of 1999.

Genetics Home Reference: PPP2R5D-related intellectual disability

Science.gov (United States)

... Health Conditions PPP2R5D-related intellectual disability PPP2R5D-related intellectual disability Printable PDF Open All Close All Enable Javascript ... view the expand/collapse boxes. Description PPP2R5D -related intellectual disability is a neurological disorder characterized by moderate to ...

Impact of GDP, spending on R&D, number of universities and scientific journals on research publications among Asian countries.

Directory of Open Access Journals (Sweden)

Sultan Ayoub Meo

Full Text Available OBJECTIVES: This study aimed to compare the impact of Gross Domestic Product (GDP per capita, spending on Research and Development (R&D, number of universities, and Indexed Scientific Journals on total number of research documents (papers, citations per document and Hirsch index (H-index in various science and social science subjects among Asian countries. MATERIALS AND METHODS: In this study, 40 Asian countries were included. The information regarding Asian countries, their GDP per capita, spending on R&D, total number of universities and indexed scientific journals were collected. We recorded the bibliometric indicators, including total number of research documents, citations per document and H-index in various science and social sciences subjects during the period 1996-2011. The main sources for information were World Bank, SCI-mago/Scopus and Web of Science; Thomson Reuters. RESULTS: The mean per capita GDP for all the Asian countries is 14448.31±2854.40 US$, yearly per capita spending on R&D 0.64±0.16 US$, number of universities 72.37±18.32 and mean number of ISI indexed journal per country is 17.97±7.35. The mean of research documents published in various science and social science subjects among all the Asian countries during the period 1996-2011 is 158086.92±69204.09; citations per document 8.67±0.48; and H-index 122.8±19.21. Spending on R&D, number of universities and indexed journals have a positive correlation with number of published documents, citations per document and H-index in various science and social science subjects. However, there was no association between the per capita GDP and research outcomes. CONCLUSION: The Asian countries who spend more on R&D have a large number of universities and scientific indexed journals produced more in research outcomes including total number of research publication, citations per documents and H-index in various science and social science subjects.

Impact of GDP, spending on R&D, number of universities and scientific journals on research publications among Asian countries.

Science.gov (United States)

Meo, Sultan Ayoub; Al Masri, Abeer A; Usmani, Adnan Mahmood; Memon, Almas Naeem; Zaidi, Syed Ziauddin

2013-01-01

This study aimed to compare the impact of Gross Domestic Product (GDP) per capita, spending on Research and Development (R&D), number of universities, and Indexed Scientific Journals on total number of research documents (papers), citations per document and Hirsch index (H-index) in various science and social science subjects among Asian countries. In this study, 40 Asian countries were included. The information regarding Asian countries, their GDP per capita, spending on R&D, total number of universities and indexed scientific journals were collected. We recorded the bibliometric indicators, including total number of research documents, citations per document and H-index in various science and social sciences subjects during the period 1996-2011. The main sources for information were World Bank, SCI-mago/Scopus and Web of Science; Thomson Reuters. The mean per capita GDP for all the Asian countries is 14448.31±2854.40 US$, yearly per capita spending on R&D 0.64±0.16 US$, number of universities 72.37±18.32 and mean number of ISI indexed journal per country is 17.97±7.35. The mean of research documents published in various science and social science subjects among all the Asian countries during the period 1996-2011 is 158086.92±69204.09; citations per document 8.67±0.48; and H-index 122.8±19.21. Spending on R&D, number of universities and indexed journals have a positive correlation with number of published documents, citations per document and H-index in various science and social science subjects. However, there was no association between the per capita GDP and research outcomes. The Asian countries who spend more on R&D have a large number of universities and scientific indexed journals produced more in research outcomes including total number of research publication, citations per documents and H-index in various science and social science subjects.

A model for atmospheric brightness temperatures observed by the special sensor microwave imager (SSM/I)

Science.gov (United States)

Petty, Grant W.; Katsaros, Kristina B.

1989-01-01

A closed-form mathematical model for the atmospheric contribution to microwave the absorption and emission at the SSM/I frequencies is developed in order to improve quantitative interpretation of microwave imagery from the Special Sensor Microwave Imager (SSM/I). The model is intended to accurately predict upwelling and downwelling atmospheric brightness temperatures at SSM/I frequencies, as functions of eight input parameters: the zenith (nadir) angle, the integrated water vapor and vapor scale height, the integrated cloud water and cloud height, the effective surface temperature, atmospheric lapse rate, and surface pressure. It is shown that the model accurately reproduces clear-sky brightness temperatures computed by explicit integration of a large number of radiosonde soundings representing all maritime climate zones and seasons.

The Implementation of C-ID, R2D2 Model on Learning Reading Comprehension

Science.gov (United States)

Rayanto, Yudi Hari; Rusmawan, Putu Ngurah

2016-01-01

The purposes of this research are to find out, (1) whether C-ID, R2D2 model is effective to be implemented on learning Reading comprehension, (2) college students' activity during the implementation of C-ID, R2D2 model on learning Reading comprehension, and 3) college students' learning achievement during the implementation of C-ID, R2D2 model on…

2D-3D shape reconstruction of the distal femur from stereo X-Ray imaging using statistical shape models

DEFF Research Database (Denmark)

Baka, N.; Kaptein, B. L.; de Bruijne, Marleen

2011-01-01

Three-dimensional patient specific bone models are required in a range of medical applications, such as pre-operative surgery planning and improved guidance during surgery, modeling and simulation, and in vivo bone motion tracking. Shape reconstruction from a small number of X-ray images is desired...... as it lowers both the acquisition costs and the radiation dose compared to CT. We propose a method for pose estimation and shape reconstruction of 3D bone surfaces from two (or more) calibrated X-ray images using a statistical shape model (SSM). User interaction is limited to manual initialization of the mean...... pose estimation of ground truth shapes as well as 3D shape estimation using a SSM of the whole femur, from stereo cadaver X-rays, in vivo biplane fluoroscopy image-pairs, and an in vivo biplane fluoroscopic sequence. Ground truth shapes for all experiments were available in the form of CT segmentations...

Estimating Typhoon Rainfall over Sea from SSM/I Satellite Data Using an Improved Genetic Programming

Science.gov (United States)

Yeh, K.; Wei, H.; Chen, L.; Liu, G.

2010-12-01

Estimating Typhoon Rainfall over Sea from SSM/I Satellite Data Using an Improved Genetic Programming Keh-Chia Yeha, Hsiao-Ping Weia,d, Li Chenb, and Gin-Rong Liuc a Department of Civil Engineering, National Chiao Tung University, Hsinchu, Taiwan, 300, R.O.C. b Department of Civil Engineering and Engineering Informatics, Chung Hua University, Hsinchu, Taiwan, 300, R.O.C. c Center for Space and Remote Sensing Research, National Central University, Tao-Yuan, Taiwan, 320, R.O.C. d National Science and Technology Center for Disaster Reduction, Taipei County, Taiwan, 231, R.O.C. Abstract This paper proposes an improved multi-run genetic programming (GP) and applies it to predict the rainfall using meteorological satellite data. GP is a well-known evolutionary programming and data mining method, used to automatically discover the complex relationships among nonlinear systems. The main advantage of GP is to optimize appropriate types of function and their associated coefficients simultaneously. This study makes an improvement to enhance escape ability from local optimums during the optimization procedure. The GP continuously runs several times by replacing the terminal nodes at the next run with the best solution at the current run. The current novel model improves GP, obtaining a highly nonlinear mathematical equation to estimate the rainfall. In the case study, this improved GP described above combining with SSM/I satellite data is employed to establish a suitable method for estimating rainfall at sea surface during typhoon periods. These estimated rainfalls are then verified with the data from four rainfall stations located at Peng-Jia-Yu, Don-Gji-Dao, Lan-Yu, and Green Island, which are four small islands around Taiwan. From the results, the improved GP can generate sophisticated and accurate nonlinear mathematical equation through two-run learning procedures which outperforms the traditional multiple linear regression, empirical equations and back-propagated network

Independent modelling in SSM's licensing review of a spent nuclear fuel repository

International Nuclear Information System (INIS)

Xu, Shulan; Dverstorp, Bjoern; Norden, Maria

2014-01-01

In 2011 the Swedish Nuclear Fuel and Waste Management Co. (SKB) submitted a license application for construction of a geological repository for spent nuclear fuel at Forsmark. SKB's disposal method, the KBS-3 method, involves disposing of the spent nuclear fuel in cast iron canisters with an outer layer of 5 cm copper. The canisters will be placed in vertical deposition holes at approximately 500 m depths in crystalline bedrock. Each canister is surrounded by a buffer of swelling bentonite clay. The repository is designed to accommodate 6 000 canisters, corresponding to 12 000 tonnes of spent nuclear fuel. The license application is supported by a post-closure safety assessment, SR-Site. Along with other parts of the application, SR-Site is currently being reviewed by the Swedish Radiation Safety Authority (SSM). The main method for review of SKB's licensing documentation is document review carried out by SSM, supported by SSM's external experts. However, SSM's document review is also supported by regulatory modelling, technical reviews of SKB's quality assurance programme and consideration of external review comments partly from two broad national consultations and an international peer review organised by the OECD's Nuclear Energy Agency (NEA, 2012). SSM's review is divided into three main phases: the initial review phase, the main review phase and the reporting phase. The overall goal of the initial review phase is to achieve a broad coverage of SR-Site and its supporting references and in particular to identify the need for complementary information and clarifications to be provided by SKB, as well as to identify critical review issues that require a more comprehensive treatment in the main review phase. SSM completed the initial review phase at the end of 2012. During the initial review phase SSM has identified a number of issues requiring either clarifications, complementary information from SKB or further in-depth review by SSM. Important issues include the

Details for Manuscript Number SSM-D-06-00290R2 “Internalized Stigma, Discrimination, and Depression among Men and Women Living with HIV/AIDS in Cape Town, South Africa”

OpenAIRE

Simbayi, Leickness C.; Strebel, Anna; Cloete, Allanise; Henda, Nomvo; Mqeketo, Ayanda

2007-01-01

AIDS stigmas interfere with HIV prevention, diagnosis and treatment and can become internalized by people living with HIV/AIDS. However, the effects of internalized AIDS stigmas have not been investigated in Africa, home to two-thirds of the more than 40 million people living with AIDS in the world. The current study examined the prevalence of discrimination experiences and internalized stigmas among 420 HIV positive men and 643 HIV positive women recruited from AIDS services in Cape Town, So...

Dicty_cDB: SSM365 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available WGS-SbicolorF (JM107 adapted methyl filtered) Sorghum bicolor genomic clone hv90e08 5', DNA sequence. 36 1.2... 2 BZ330175 |BZ330175.1 hv90e08.g1 WGS-SbicolorF (JM107 adapted methyl filtered) ...rF (JM107 adapted methyl filtered) Sorghum bicolor genomic clone hz26f02 5', DNA sequence. 36 1.4 2 BZ628823... |BZ628823.1 ih62d12.g1 WGS-SbicolorF (DH5a methyl filtered) Sorghum bicolor geno...mic clone ih62d12 5', DNA sequence. 36 1.7 2 BZ340606 |BZ340606.1 ic39h07.b1 WGS-SbicolorF (JM107 adapted methyl filter

DMSP SSM/I- Microwave Imager

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The SSM/I is a seven-channel, four frequency, linearly-polarized, passive microwave radiometric system which measures atmospheric, ocean and terrain microwave...

Preparing and Publishing a Scientific Manuscript

Directory of Open Access Journals (Sweden)

Padma R Jirge

2017-01-01

Full Text Available Publishing original research in a peer-reviewed and indexed journal is an important milestone for a scientist or a clinician. It is an important parameter to assess academic achievements. However, technical and language barriers may prevent many enthusiasts from ever publishing. This review highlights the important preparatory steps for creating a good manuscript and the most widely used IMRaD (Introduction, Materials and Methods, Results, and Discussion method for writing a good manuscript. It also provides a brief overview of the submission and review process of a manuscript for publishing in a biomedical journal.

Startup, Shutdown, & Malfunction (SSM) Emissions

Science.gov (United States)

EPA issued a final action to ensure states have plans in place that are fully consistent with the Clean Air Act and recent court decisions concerning startup, shutdown and malfunction (SSM) operations.

Analysis of various types of single-polypeptide-chain (sc) heterodimeric A{sub 2A}R/D{sub 2}R complexes and their allosteric receptor–receptor interactions

Energy Technology Data Exchange (ETDEWEB)

Kamiya, Toshio, E-mail: kamiya@z2.keio.jp [Department of Molecular Cell Signaling, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526 (Japan); Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526 (Japan); Cell Biology Laboratory, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502 (Japan); Yoshioka, Kazuaki; Nakata, Hiroyasu [Department of Molecular Cell Signaling, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526 (Japan)

2015-01-09

Highlights: • Various scA{sub 2A}R/D{sub 2}R constructs, with spacers between the two receptors, were created. • Using whole cell binding assay, constructs were examined for their binding activity. • Although the apparent ratio of A{sub 2A}R to D{sub 2}R binding sites should be 1, neither was 1. • Counter agonist-independent binding cooperativity occurred in context of scA{sub 2A}R/D{sub 2}R. - Abstract: Adenosine A{sub 2A} receptor (A{sub 2A}R) heteromerizes with dopamine D{sub 2} receptor (D{sub 2}R). However, these class A G protein-coupled receptor (GPCR) dimers are not fully formed, but depend on the equilibrium between monomer and dimer. In order to stimulate the heteromerization, we have previously shown a successful design for a fusion receptor, single-polypeptide-chain (sc) heterodimeric A{sub 2A}R/D{sub 2}R complex. Here, using whole cell binding assay, six more different scA{sub 2A}R/D{sub 2}R constructs were examined. Not only in scA{sub 2A}R/D{sub 2}R ‘liberated’ with longer spacers between the two receptors, which confer the same configuration as the prototype, the A{sub 2A}R-odr4TM-D{sub 2L}R, but differ in size (Forms 1–3), but also in scA{sub 2A}R/D{sub 2L}R (Form 6) fused with a transmembrane (TM) of another type II TM protein, instead of odr4TM, neither of their fixed stoichiometry (the apparent ratios of A{sub 2A}R to D{sub 2}R binding sites) was 1, suggesting their compact folding. This suggests that type II TM, either odr4 or another, facilitates the equilibrial process of the dimer formation between A{sub 2A}R and D{sub 2L}R, resulting in the higher-order oligomer formation from monomer of scA{sub 2A}R/D{sub 2L}R itself. Also, in the reverse type scA{sub 2A}R/D{sub 2L}R, i.e., the D{sub 2L}R-odr4TM-A{sub 2A}R, counter agonist-independent binding cooperativity (cooperative folding) was found to occur (Forms 4 and 5). In this way, the scA{sub 2A}R/D{sub 2L}R system has unveiled the cellular phenomenon as a snapshot of the

Impact of GDP, spending on R&D, number of universities and scientific journals on research publications in pharmacological sciences in Middle East.

Science.gov (United States)

Meo, S A; Usmani, A M; Vohra, M S; Bukhari, I A

2013-10-01

Research in pharmacological science is vital to support the health needs of human beings. Measuring the research output provides information that forms the basis of strategic decisions. This study aimed to investigate the impact of Gross Domestic Product (GDP), spending on Research and Development (R&D), number of universities and scientific journals on research documents (papers), citable documents, citations per document and H-index in pharmacological science among Middle East countries. All the 16 Middle East countries were included in the study. The information regarding GDP, spending on R&D, total number of universities and indexed scientific journals were collected. We recorded the total number of research documents, citable documents, citations per document and H-index in pharmacological science during the period 1996-2011. The main sources for information were World Bank, Web of Science, Journal Citation Reports (Thomson Reuters) and SCI-mago/Scopus. The mean per capita GDP of all the Middle East countries is 18125.49±5386.28 US$, spending on R&D 0.63±0.28% of GDP in US$, number of universities 36.56±11.33 and mean ISI indexed journal are 8.25±3.93. The number of research documents published in pharmacological science among the Middle East countries during the period 1996-2011 is 1344.44±499.34; citable documents 1286.37±476.34; citations per document 7.62± 0.84; and H-index is 30.68±6.32. There was a positive correlation between spending on R&D and citations per documents (r = 0.56, p = 0.02), H-Index (r = 0.56, p = 0.02); number of universities and research documents (r = 0.72, p = 0.002), citable documents (r = 0.72, p = 0.001); ISI indexed journals and research documents (r = 0.88, p = 0.0001), citable documents (r = 0.88, p = 0.0001), H-Index (r = 0.67, p = 0.004). However, there was no correlation between the GDP per capita and research outcome in pharmacological science. There is a positive association between spending on R&D, number of

Radio evidence for the initial stellar mass function in the R associations CMa R1, Mon R1, Mon R2

International Nuclear Information System (INIS)

Pyatunina, T.B.

1985-01-01

The R associations CMa R1 and Mon R1 have been searched for compact 7.6-cm sources with the RATAN-600 radio telescope. The Mon R1 region shows only about the expected number of background radio galaxies; in CMa R1 seven sources of small angular size with S> or =30 mJy have been found, two of them probably background objects. Comparison with optical data for CMa R1, together with previous RATAN-600 data for Mon R2, yields an initial mass function xi(M)proportionalM/sup -2.7plus-or-minus0.7/ for the rather massive (Mroughly-equal10 M/sub sun/) stars in these associations

Comparative d2/d3 LSU–rDNA sequence study of some Iranian ...

African Journals Online (AJOL)

SERVER

2007-11-05

Nov 5, 2007 ... segments yielded one fragment at over all sequenced isolates as 787 bp in size. The DNA sequences were aligned .... expansion segments of the 28S rDNA subunit (D2/D3. LSU-rDNA) are the ... isolated from different geographical location from tea shrubs infested roots of Guilan province, Iran (Table 1).

Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats

Czech Academy of Sciences Publication Activity Database

Folbergrová, Jaroslava; Druga, Rastislav; Tsenov, Grygoriy; Haugvicová, Renata; Otáhal, Jakub

2009-01-01

Roč. 1273, - (2009), s. 144-154 ISSN 0006-8993 R&D Projects: GA ČR(CZ) GA309/05/2015; GA ČR GA309/08/0292; GA ČR(CZ) GA304/07/1137 Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z50200510 Keywords : DL-homocysteic acid-induced seizures * posttreatment with 2R * 4R-APDC * partial protection Subject RIV: FH - Neuro logy Impact factor: 2.463, year: 2009

Intrastriatal administration of botulinum neurotoxin A normalizes striatal D2 R binding and reduces striatal D1 R binding in male hemiparkinsonian rats.

Science.gov (United States)

Wedekind, Franziska; Oskamp, Angela; Lang, Markus; Hawlitschka, Alexander; Zilles, Karl; Wree, Andreas; Bauer, Andreas

2018-01-01

Cerebral administration of botulinum neurotoxin A (BoNT-A) has been shown to improve disease-specific motor behavior in a rat model of Parkinson disease (PD). Since the dopaminergic system of the basal ganglia fundamentally contributes to motor function, we investigated the impact of BoNT-A on striatal dopamine receptor expression using in vitro and in vivo imaging techniques (positron emission tomography and quantitative autoradiography, respectively). Seventeen male Wistar rats were unilaterally lesioned with 6-hydroxydopamine (6-OHDA) and assigned to two treatment groups 7 weeks later: 10 rats were treated ipsilaterally with an intrastriatal injection of 1 ng BoNT-A, while the others received vehicle (n = 7). All animals were tested for asymmetric motor behavior (apomorphine-induced rotations and forelimb usage) and for striatal expression of dopamine receptors and transporters (D 1 R, D 2 R, and DAT). The striatal D 2 R availability was also quantified longitudinally (1.5, 3, and 5 months after intervention) in 5 animals per treatment group. The 6-OHDA lesion alone induced a unilateral PD-like phenotype and a 13% increase of striatal D 2 R. BoNT-A treatment reduced the asymmetry in both apomorphine-induced rotational behavior and D 2 R expression, with the latter returning to normal values 5 months after intervention. D 1 R expression was significantly reduced, while DAT concentrations showed no alteration. Independent of the treatment, higher interhemispheric symmetry in raclopride binding to D 2 R was generally associated with reduced forelimb akinesia. Our findings indicate that striatal BoNT-A treatment diminishes motor impairment and induces changes in D 1 and D 2 binding site density in the 6-OHDA rat model of PD. © 2017 Wiley Periodicals, Inc.

CLUES on Fermi-LAT prospects for the extragalactic detection of {mu}{nu}SSM gravitino dark matter

Energy Technology Data Exchange (ETDEWEB)

Gomez-Vargas, G.A., E-mail: germanarturo.gomez@uam.es [Departamento de Fisica Teorica, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Instituto de Fisica Teorica IFT-UAM/CSIC, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Istituto Nazionale di Fisica Nucleare, Sez. Roma Tor Vergata, Roma (Italy)

2012-11-11

The {mu}{nu}SSM is a supersymmetric model that has been proposed to solve the problems generated by other supersymmetric extensions of the standard model of particle physics. Given that R-parity is broken in the {mu}{nu}SSM, the gravitino is a natural candidate for decaying dark matter since its lifetime becomes much longer than the age of the Universe. In this model, gravitino dark matter could be detectable through the emission of a monochromatic gamma ray in a two-body decay. We study the prospects of the Fermi-LAT telescope to detect such monochromatic lines in 5 years of observations of the most massive nearby extragalactic objects. We focus on the Virgo galaxy cluster, since it is associated to a particularly high signal-to-noise ratio and is located at high Galactic latitude. The simulation of both signal and background gamma-ray events is carried out with the Fermi Science Tools, and the dark matter distribution around Virgo is taken from an N-body simulation, with constrained initial conditions provided by the CLUES project. We find that a gravitino with a mass range of 0.6-2 GeV, and with a lifetime range of about 3 Multiplication-Sign 10{sup 27}-2 Multiplication-Sign 10{sup 28}s would be detectable by the Fermi-LAT with a signal-to-noise ratio larger than 3. We also obtain that gravitino masses larger than about 4 GeV are already excluded in the {mu}{nu}SSM by Fermi-LAT data of the galactic halo. These proceedings are based on Ref. [1].

Faculty Employment and R&D Expenditures at Research Universities

Science.gov (United States)

Zhang, Liang; Ehrenberg, Ronald G.

2010-01-01

This study uses panel data to examine the relationship between faculty employment and external R&D expenditures at Research and Doctoral institutions over a 15-year period of time. On average, a 1% increase in the number of full-time faculty is associated with about 0.2% increase in total R&D expenditure. Further, a one percentage point increase…

A peptide disrupting the D2R-DAT interaction protects against dopamine neurotoxicity.

Science.gov (United States)

Su, Ping; Liu, Fang

2017-09-01

Dopamine reuptake from extracellular space to cytosol leads to accumulation of dopamine, which triggers neurotoxicity in dopaminergic neurons. Previous studies have shown that both dopamine D2 receptor (D2R) and dopamine transporter (DAT) are involved in dopamine neurotoxicity. However, blockade of either D2R or DAT causes side effects due to antagonism of other physiological functions of these two proteins. We previously found that DAT can form a protein complex with D2R and its cell surface expression is facilitated via D2R-DAT interaction, which regulates dopamine reuptake and intracellular dopamine levels. Here we found that an interfering peptide (DAT-S1) disrupting the D2R-DAT interaction protects neurons against dopamine neurotoxicity, and this effect is mediated by inhibiting DAT cell surface expression and inhibiting both caspase-3 and PARP-1 cleavage. This study demonstrates the role of the D2R-DAT complex in dopamine neurotoxicity and investigated the potential mechanisms, which might help better understand the mechanisms of dopamine neurotoxicity. The peptide may provide some insights to improve treatments for dopamine neurotoxicity and related diseases, such as Parkinson's disease, as well as methamphetamine- and 3,4-methsylenedioxy methamphetamine-induced neurotoxicity. Copyright © 2017. Published by Elsevier Inc.

On Wilson bases in $L^2(\\mathbb{R}^d)$

DEFF Research Database (Denmark)

Bownik, Marcin; Sielemann Jakobsen, Mads; Lemvig, Jakob

2017-01-01

A Wilson system is a collection of finite linear combinations of time frequency shifts of a square integrable function. It is well known that, starting from a tight Gabor frame for $L^{2}(\\mathbb{R})$ with redundancy 2, one can construct an orthonormal Wilson basis for $L^2(\\mathbb{R})$ whose...... of redundancy $2^k$, where $k=1, 2, \\hdots, d$. These results generalize most of the known results about the existence of orthonormal Wilson bases....

Impact of GDP, spending on R&D, the number of universities and scientific journals on research publications in environmental sciences in the Middle East

Directory of Open Access Journals (Sweden)

Sultan Ayoub Meo

2013-10-01

Full Text Available Objectives: This study aimed to assess the impact of the Gross Domestic Product (GDP, spending on Research and Development (R&D, the number of universities and scientific journals on the published research documents, citable documents, citations per document and H-index in environmental sciences in the Middle East countries. Materials and Methods: All the 16 Middle East countries were included in the study. Information regarding the GDP, spending on R&D, the total number of universities and indexed journals was collected. Total number of research documents (papers, citable documents, citations per document and H-index in environmental sciences during the period 1996-2011 was recorded. The study used the World Bank, SCI-mago/Scopus, Web of Science, Journal Citation Reports (Thomson Reuters as the main sources of information. Results: The mean GDP per capita of all the Middle East countries amounted to 18 125.49±5386.28 US$, spending on R&D was 0.63±0.28 US$, the number of universities equaled 36.56±11.33 and mean ISI indexed journals amounted to 8.25±3.93. The mean number of research documents published in environmental sciences in the Middle East countries during the period 1996-2011 was 2202.12±883.98; citable documents: 2156.87±865.09; citations per document: 8.74±0.73; and the H-index: 35.37±6.17. There was a positive correlation between the money spent on R&D and citations per documents (r = 0.6, p = 0.01, H-Index (r = 0.6, p = 0.01; the number of universities and a total of research documents (r = 0.65, p = 0.006, citable documents (r = 0.65, p = 0.006, H-Index (r = 0.50, p = 0.04, as well as ISI indexed journals and total research documents (r = 0.94, p = 0.0001, citable documents (r = 0.94, p = 0.0001, H-Index (r = 0.73, p = 0.001. Conclusions: The Middle East countries which spend more on R&D and which have a large number of universities and ISI indexed journals are likely to produce more significant volume of research papers in

Impact of GDP, spending on R&D, the number of universities and scientific journals on research publications in environmental sciences in the Middle East.

Science.gov (United States)

Meo, Sultan Ayoub; Al Masri, Abeer A; Usmani, Adnan Mahmood; Halepoto, Dost Muhammad

2013-10-01

This study aimed to assess the impact of the Gross Domestic Product (GDP), spending on Research and Development (R&D), the number of universities and scientific journals on the published research documents, citable documents, citations per document and H-index in environmental sciences in the Middle East countries. All the 16 Middle East countries were included in the study. Information regarding the GDP, spending on R&D, the total number of universities and indexed journals was collected. Total number of research documents (papers), citable documents, citations per document and H-index in environmental sciences during the period 1996-2011 was recorded. The study used the World Bank, SCI-mago/Scopus, Web of Science, Journal Citation Reports (Thomson Reuters) as the main sources of information. The mean GDP per capita of all the Middle East countries amounted to 18 125.49±5386.28 US$, spending on R&D was 0.63±0.28 US$, the number of universities equaled 36.56±11.33 and mean ISI indexed journals amounted to 8.25±3.93. The mean number of research documents published in environmental sciences in the Middle East countries during the period 1996-2011 was 2202.12±883.98; citable documents: 2156.87±865.09; citations per document: 8.74±0.73; and the H-index: 35.37±6.17. There was a positive correlation between the money spent on R&D and citations per documents (r = 0.6, p = 0.01), H-Index (r = 0.6, p = 0.01); the number of universities and a total of research documents (r = 0.65, p = 0.006), citable documents (r = 0.65, p = 0.006), H-Index (r = 0.50, p = 0.04), as well as ISI indexed journals and total research documents (r = 0.94, p = 0.0001), citable documents (r = 0.94, p = 0.0001), H-Index (r = 0.73, p = 0.001). The Middle East countries which spend more on R&D and which have a large number of universities and ISI indexed journals are likely to produce more significant volume of research papers in the field of environmental science.

Measurement of the {ital D}{sup +}{sub {ital s}}{r_arrow}{eta}l{sup +}{nu} and {ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{prime}l{sup +}{nu} branching ratios

Energy Technology Data Exchange (ETDEWEB)

Brandenburg, G.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; McLean, K.W.; Ogg, M.; Bellerive, A.; Britton, D.I.; Hyatt, E.R.F.; Janicek, R.; MacFarlane, D.B.; Patel, P.M.; Spaan, B.; Sadoff, A.J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N.; Kubota, Y.; Lattery, M.; Momayezi, M.; Nelson, J.K.; Patton, S.; Poling, R.; Savinov, V.; Schrenk, S.; Wang, R.; Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; O`Neill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Duboscq, J.E.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Miao, T.; Miller, D.H.; Modesitt, M.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Gibbons, L.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Coan, T.E.; Dominick, J.; Fadeyev, V.; Korolkov, I.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Kopp, S.; Moneti, G.C.; Mountain, R.; Muheim, F.; Mukhin, Y.; Playfer, S.; Stone, S.; Xing, X.; Bartelt, J.; Csorna, S.E.; Jain, V.; Marka, S.; Gibaut, D.; Kinoshita, K.; Pomianowski, P.; Barish, B.; Chadha, M.; Chan, S.; Cowen, D.F.; Eigen, G.; Miller, J.S.; O`Grady, C.; Urheim, J.; Weinstein, A.J.; Wuerthwein, F.; Asner, D.M.; Athanas, M.; Bliss, D.W.; Brower, W.S.; Masek, G.; Paar, H.P.; Gronberg, J.; Korte, C.M.; Kutschke, R.; Menary, S.; Morrison, R.J.; Nakanishi, S.; Nelson, H.N.; Nelson, T.K.; Qiao, C.; Richman, J.D.; Roberts, D.; Ryd, A.; Tajima, H.; Witherell, M.S.; Balest, R.; Cho, K.; Ford, W.T.; Lohner, M.; Park, H.; Rankin, P.; Smith, J.G.; Alexander, J.P.; (CLEO Collaborat...

1995-11-20

Using the CLEO II detector we measure {ital B}({ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{ital e}{sup +}{nu})/{ital B}({ital D}{sup +}{sub {ital s}}{r_arrow}{phi}{ital e}{sup +}{nu}) =1.24{plus_minus}0.12{plus_minus}0.15, {ital B}({ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{prime}{ital e}{sup +}{nu})/{ital B} ({ital D}{sup +}{sub {ital s}}{r_arrow}{phi}{ital e}{sup +}{nu})=0.43{plus_minus}0.11{plus_minus}0.07, and {ital B}({ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{prime}{ital e}{sup +}{nu})/{ital B} ({ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{ital e}{sup +}{nu})=0.35{plus_minus}0.09{plus_minus}0.07. We find the ratio of vector to pseudoscalar final states, {ital B}{bold (}{ital D}{sup +}{sub {ital s}}{r_arrow}{phi}{ital e}{sup +}{nu})/{ital B} ({ital D}{sup +}{sub {ital s}}{r_arrow}({eta}+{eta}{prime}){ital e}{sup +}{nu}{bold )}=0.60{plus_minus}0.06{plus_minus}0.06, which is similar to the ratio found in nonstrange {ital D} decays. {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.

DR Argillite Disposal R&D at LBNL

Energy Technology Data Exchange (ETDEWEB)

Zheng, Liange [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kim, Kunhwi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Xu, Hao [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rutqvist, Jonny [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2016-08-12

Within the Natural Barrier System (NBS) group of the Used Fuel Disposition (UFD) Campaign at the Department of Energy’s (DOE) Office of Nuclear Energy, LBNL’s research activities have focused on understanding and modeling EDZ evolution and the associated coupled processes and impacts of high temperature on parameters and processes relevant to performance of a clay repository to establish the technical base for the maximum allowable temperature. This report documents results from some of these activities. These activities address key Features, Events, and Processes (FEPs), which have been ranked in importance from medium to high, as listed in Table 7 of the Used Fuel Disposition Campaign Disposal Research and Development Roadmap (FCR&D-USED-2011-000065 REV0) (Nutt, 2011). Specifically, they address FEP 2.2.01, Excavation Disturbed Zone, for clay/shale, by investigating how coupled processes affect EDZ evolution; FEP 2.2.05, Flow and Transport Pathways; and FEP 2.2.08, Hydrologic Processes, and FEP 2.2.07, Mechanical Processes, and FEP 2.2.09, Chemical Process—Transport, by studying near-field coupled THMC processes in clay/shale repositories. The activities documented in this report also address a number of research topics identified in Research & Development (R&D) Plan for Used Fuel Disposition Campaign (UFDC) Natural System Evaluation and Tool Development (Wang 2011), including Topics S3, Disposal system modeling – Natural System; P1, Development of discrete fracture network (DFN) model; P14, Technical basis for thermal loading limits; and P15 Modeling of disturbed rock zone (DRZ) evolution (clay repository).

DR Argillite Disposal R&D at LBNL

International Nuclear Information System (INIS)

Zheng, Liange; Kim, Kunhwi; Xu, Hao; Rutqvist, Jonny

2016-01-01

Within the Natural Barrier System (NBS) group of the Used Fuel Disposition (UFD) Campaign at the Department of Energy's (DOE) Office of Nuclear Energy, LBNL's research activities have focused on understanding and modeling EDZ evolution and the associated coupled processes and impacts of high temperature on parameters and processes relevant to performance of a clay repository to establish the technical base for the maximum allowable temperature. This report documents results from some of these activities. These activities address key Features, Events, and Processes (FEPs), which have been ranked in importance from medium to high, as listed in Table 7 of the Used Fuel Disposition Campaign Disposal Research and Development Roadmap (FCR&D-USED-2011-000065 REV0) (Nutt, 2011). Specifically, they address FEP 2.2.01, Excavation Disturbed Zone, for clay/shale, by investigating how coupled processes affect EDZ evolution; FEP 2.2.05, Flow and Transport Pathways; and FEP 2.2.08, Hydrologic Processes, and FEP 2.2.07, Mechanical Processes, and FEP 2.2.09, Chemical Process-Transport, by studying near-field coupled THMC processes in clay/shale repositories. The activities documented in this report also address a number of research topics identified in Research & Development (R&D) Plan for Used Fuel Disposition Campaign (UFDC) Natural System Evaluation and Tool Development (Wang 2011), including Topics S3, Disposal system modeling - Natural System; P1, Development of discrete fracture network (DFN) model; P14, Technical basis for thermal loading limits; and P15 Modeling of disturbed rock zone (DRZ) evolution (clay repository).

Similarities between 2D and 3D convection for large Prandtl number

Indian Academy of Sciences (India)

2016-06-18

RBC), we perform a compara- tive study of the spectra and fluxes of energy and entropy, and the scaling of large-scale quantities for large and infinite Prandtl numbers in two (2D) and three (3D) dimensions. We observe close ...

Fate of manuscripts rejected by a non-English-language general medical journal

DEFF Research Database (Denmark)

Vinther, Siri; Rosenberg, Jacob

2011-01-01

Objective The objective of this study was to determine whether, where and when manuscripts were published following rejection by the Journal of the Danish Medical Association, a general medical journal published in Danish. Similar previous studies have focused on specialty/subspecialty journals...... published in English. Design Manuscripts rejected during a 4-year period were searched for in PubMed and Embase in order to assess the percentage of manuscripts subsequently published in other journals. In addition, characteristics of both the published manuscripts and the journals in which they were...... evaluated. Results Of 198 rejected manuscripts, 21 (10.6%) were eventually published after a median of 685 days (range 209-1463). The majority of these were original research, published in English-language specialty/subspecialty journals. The median number of citations per article was 2-3 (IQR 0...

The SSM/PMAD automated test bed project

Science.gov (United States)

Lollar, Louis F.

1991-01-01

The Space Station Module/Power Management and Distribution (SSM/PMAD) autonomous subsystem project was initiated in 1984. The project's goal has been to design and develop an autonomous, user-supportive PMAD test bed simulating the SSF Hab/Lab module(s). An eighteen kilowatt SSM/PMAD test bed model with a high degree of automated operation has been developed. This advanced automation test bed contains three expert/knowledge based systems that interact with one another and with other more conventional software residing in up to eight distributed 386-based microcomputers to perform the necessary tasks of real-time and near real-time load scheduling, dynamic load prioritizing, and fault detection, isolation, and recovery (FDIR).

CLUES on Fermi-LAT prospects for the extragalactic detection of μνSSM gravitino dark matter

Energy Technology Data Exchange (ETDEWEB)

Gómez-Vargas, G.A.; Muñoz, C.; Yepes, G. [Departamento de Física Teórica, Universidad Autónoma de Madrid, Cantoblanco, E-28049, Madrid (Spain); Fornasa, M.; Zandanel, F.; Prada, F. [Instituto de Astrofísica de Andalucía (CSIC), E-18008, Granada (Spain); Cuesta, A.J., E-mail: germanarturo.gomez@uam.es, E-mail: mattia@iaa.es, E-mail: fabio@iaa.es, E-mail: antonio.cuesta@yale.edu, E-mail: carlos.munnoz@uam.es, E-mail: fprada@iaa.es, E-mail: gustavo.yepes@uam.es [Yale Center for Astronomy and Astrophysics, Yale University, CT 06511, New Haven (United States)

2012-02-01

The μνSSM is a supersymmetric model that has been proposed to solve the problems generated by other supersymmetric extensions of the standard model of particle physics. Given that R-parity is broken in the μνSSM, the gravitino is a natural candidate for decaying dark matter since its lifetime becomes much longer than the age of the Universe. In this model, gravitino dark matter could be detectable through the emission of a monochromatic gamma ray in a two-body decay. We study the prospects of the Fermi-LAT telescope to detect such monochromatic lines in 5 years of observations of the most massive nearby extragalactic objects. The dark matter halo around the Virgo galaxy cluster is selected as a reference case, since it is associated to a particularly high signal-to-noise ratio and is located in a region scarcely affected by the astrophysical diffuse emission from the galactic plane. The simulation of both signal and background gamma-ray events is carried out with the Fermi Science Tools, and the dark matter distribution around Virgo is taken from a N-body simulation of the nearby extragalactic Universe, with constrained initial conditions provided by the CLUES project. We find that a gravitino with a mass range of 0.6–2 GeV, and with a lifetime range of about 3 × 10{sup 27}–2 × 10{sup 28} s would be detectable by the Fermi-LAT with a signal-to-noise ratio larger than 3. We also obtain that gravitino masses larger than about 4 GeV are already excluded in the μνSSM by Fermi-LAT data of the galactic halo.

A systematic methodology for creep master curve construction using the stepped isostress method (SSM): a numerical assessment

Science.gov (United States)

Miranda Guedes, Rui

2018-02-01

Long-term creep of viscoelastic materials is experimentally inferred through accelerating techniques based on the time-temperature superposition principle (TTSP) or on the time-stress superposition principle (TSSP). According to these principles, a given property measured for short times at a higher temperature or higher stress level remains the same as that obtained for longer times at a lower temperature or lower stress level, except that the curves are shifted parallel to the horizontal axis, matching a master curve. These procedures enable the construction of creep master curves with short-term experimental tests. The Stepped Isostress Method (SSM) is an evolution of the classical TSSP method. Higher reduction of the required number of test specimens to obtain the master curve is achieved by the SSM technique, since only one specimen is necessary. The classical approach, using creep tests, demands at least one specimen per each stress level to produce a set of creep curves upon which TSSP is applied to obtain the master curve. This work proposes an analytical method to process the SSM raw data. The method is validated using numerical simulations to reproduce the SSM tests based on two different viscoelastic models. One model represents the viscoelastic behavior of a graphite/epoxy laminate and the other represents an adhesive based on epoxy resin.

UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1

International Nuclear Information System (INIS)

Yasuda, Kaori; Endo, Mariko; Ikushiro, Shinichi; Kamakura, Masaki; Ohta, Miho; Sakaki, Toshiyuki

2013-01-01

Highlights: •We produce 25-hydroxyvitamin D in the recombinant yeast expressing human CYP2R1. •Vitamin D2 is produced in yeast from endogenous ergosterol with UV irradiation. •We produce 25-hydroxyvitamin D2 in the recombinant yeast without added substrate. -- Abstract: CYP2R1 is known to be a physiologically important vitamin D 25-hydroxylase. We have successfully expressed human CYP2R1 in Saccharomyces cerevisiae to reveal its enzymatic properties. In this study, we examined production of 25-hydroxylated vitamin D using whole recombinant yeast cells that expressed CYP2R1. When vitamin D 3 or vitamin D 2 was added to the cell suspension of CYP2R1-expressing yeast cells in a buffer containing glucose and β-cyclodextrin, the vitamins were converted into their 25-hydroxylated products. Next, we irradiated the cell suspension with UVB and incubated at 37 °C. Surprisingly, the 25-hydroxy vitamin D 2 was produced without additional vitamin D 2 . Endogenous ergosterol was likely converted into vitamin D 2 by UV irradiation and thermal isomerization, and then the resulting vitamin D 2 was converted to 25-hydroxyvitamin D 2 by CYP2R1. This novel method for producing 25-hydroxyvitamin D 2 without a substrate could be useful for practical purposes

Physical retrieval of precipitation water contents from Special Sensor Microwave/Imager (SSM/I) data. Part 2: Retrieval method and applications (report version)

Science.gov (United States)

Olson, William S.

1990-01-01

A physical retrieval method for estimating precipitating water distributions and other geophysical parameters based upon measurements from the DMSP-F8 SSM/I is developed. Three unique features of the retrieval method are (1) sensor antenna patterns are explicitly included to accommodate varying channel resolution; (2) precipitation-brightness temperature relationships are quantified using the cloud ensemble/radiative parameterization; and (3) spatial constraints are imposed for certain background parameters, such as humidity, which vary more slowly in the horizontal than the cloud and precipitation water contents. The general framework of the method will facilitate the incorporation of measurements from the SSMJT, SSM/T-2 and geostationary infrared measurements, as well as information from conventional sources (e.g., radiosondes) or numerical forecast model fields.

miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

International Nuclear Information System (INIS)

Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

2015-01-01

Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2

miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

Energy Technology Data Exchange (ETDEWEB)

Li, Xuesong; Gong, Xuhai [Department of Neurology, Daqing Oilfield General Hospital, Daqing, Heilongjiang 163001 (China); Chen, Jing [Department of Neurology, Daqing Longnan Hospital, Daqing, Heilongjiang, 163001 China (China); Zhang, Jinghui [Department of Cardiology, The Fourth Hospital of Harbin City, Harbin, Heilongjiang 150026 (China); Sun, Jiahang [Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086 (China); Guo, Mian, E-mail: guomian_hyd@163.com [Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086 (China)

2015-05-08

Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

Studsvik`s fuel R and D projects

Energy Technology Data Exchange (ETDEWEB)

Grounes, M [Studsvik Nuclearr AB, Nykoping (Sweden)

1997-08-01

The report reviews some recently performed, ongoing and planned fuel R and D projects, executed by Studsvik Nuclear AB, a subsidiary of Studsvik AB. Data from these projects are used as experimental support for fuel modelling at high burnup. Much of Studsvik Nuclear`s R and D work has been concentrated on fuel testing, which can be made in the R2 test reactor with high precision under realistic water reactor conditions. This type of work started in the early 1960s. The fuel testing projects executed at Studsvik have been organized under three different types of sponsorship: International (multilateral) fuel projects: jointly sponsored internationally on a world-wide basis, with project information remaining restricted to the project participants throughout the project`s duration and for some pre-determined time after project completion; Bilateral fuel projects: sponsored by one single organization, or a few co-operating organizations, with project information remaining restricted to the sponsor, sometimes published later; in-house R and D work: sponsored by Studsvik Nuclear. The fuel testing activities can be divided into a number of well-defined steps as follows: Base irradiation, performed in a power reactor, or in Studsvik`s R2 test reactor; power ramping and/or other in-pile measurements, performed in Studsvik`s R2 test reactor. Non-destructive testing between different phases of an experiment, performed in Studsvik`s R2 reactor pool, or in Studsvik`s Hot Cell Laboratory; destructive post-irradiation examinations, performed in Studsvik`s Hot Cell Laboratory, or in the sponsor`s hot cell laboratory. 47 refs, 2 tabs.

Instability of the ferromagnetic ground state in Lu.sub.2./sub.Fe.sub.17-x./sub.Mn.sub.x./sub. [x = 0.5, 0.7

Czech Academy of Sciences Publication Activity Database

Arnold, Zdeněk; Kuchin, A.; Kamarád, Jiří

2012-01-01

Roč. 111, č. 7 (2012), "07E310-1"-"07E310-3" ISSN 0021-8979 R&D Projects: GA ČR GA202/09/1027 Institutional research plan: CEZ:AV0Z10100521 Keywords : ferromagnetic ground state, Magnetic moments * magnetic moments Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.210, year: 2012

The development and optimisation of 3D black-blood R2* mapping of the carotid artery wall.

Science.gov (United States)

Yuan, Jianmin; Graves, Martin J; Patterson, Andrew J; Priest, Andrew N; Ruetten, Pascal P R; Usman, Ammara; Gillard, Jonathan H

2017-12-01

To develop and optimise a 3D black-blood R 2 * mapping sequence for imaging the carotid artery wall, using optimal blood suppression and k-space view ordering. Two different blood suppression preparation methods were used; Delay Alternating with Nutation for Tailored Excitation (DANTE) and improved Motion Sensitive Driven Equilibrium (iMSDE) were each combined with a three-dimensional (3D) multi-echo Fast Spoiled GRadient echo (ME-FSPGR) readout. Three different k-space view-order designs: Radial Fan-beam Encoding Ordering (RFEO), Distance-Determined Encoding Ordering (DDEO) and Centric Phase Encoding Order (CPEO) were investigated. The sequences were evaluated through Bloch simulation and in a cohort of twenty volunteers. The vessel wall Signal-to-Noise Ratio (SNR), Contrast-to-Noise Ratio (CNR) and R 2 *, and the sternocleidomastoid muscle R 2 * were measured and compared. Different numbers of acquisitions-per-shot (APS) were evaluated to further optimise the effectiveness of blood suppression. All sequences resulted in comparable R 2 * measurements to a conventional, i.e. non-blood suppressed sequence in the sternocleidomastoid muscle of the volunteers. Both Bloch simulations and volunteer data showed that DANTE has a higher signal intensity and results in a higher image SNR than iMSDE. Blood suppression efficiency was not significantly different when using different k-space view orders. Smaller APS achieved better blood suppression. The use of blood-suppression preparation methods does not affect the measurement of R 2 *. DANTE prepared ME-FSPGR sequence with a small number of acquisitions-per-shot can provide high quality black-blood R 2 * measurements of the carotid vessel wall. Copyright © 2017 Elsevier Inc. All rights reserved.

Syntheses of 24R,25-dihydroxy-[6,19,19-3H]vitamin D3 and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3

International Nuclear Information System (INIS)

Yamada, S.; Shimizu, M.; Fukushima, K.; Niimura, K.; Maeda, Y.

1989-01-01

24R,25-Dihydroxy-[6,19,19-3H]vitamin D3 with a specific activity of 54 Ci/mmol and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3 with 2.6 deuterium atoms/mol were synthesized in four steps starting from 24R,25-Dihydroxyvitamin D3 via its sulfur dioxide adduct

PySSM: A Python Module for Bayesian Inference of Linear Gaussian State Space Models

Directory of Open Access Journals (Sweden)

Christopher Strickland

2014-04-01

Full Text Available PySSM is a Python package that has been developed for the analysis of time series using linear Gaussian state space models. PySSM is easy to use; models can be set up quickly and efficiently and a variety of different settings are available to the user. It also takes advantage of scientific libraries NumPy and SciPy and other high level features of the Python language. PySSM is also used as a platform for interfacing between optimized and parallelized Fortran routines. These Fortran routines heavily utilize basic linear algebra and linear algebra Package functions for maximum performance. PySSM contains classes for filtering, classical smoothing as well as simulation smoothing.

Internationalisation of R&D

DEFF Research Database (Denmark)

Haakonsson, Stine Jessen; Ujjual, Vandana

2015-01-01

study of a global firm from the most globalised industry in terms of R&D, biotechnology. The article investigates dynamics of internationalisation of R&D in global networks by looking at: 1) the strategic drivers of location, either as a large potential market or as a pool of competencies; and 2......) the evolution of the company and its R&D activities into emerging market locations: India, China and Brazil. Together, these two dimensions constitute the drivers of R&D internationalisation and contribute to the construction of global innovation networks through knowledge augmenting and exploiting strategies....... The article shows how multinational enterprises can use a combination of augmenting and exploiting strategies in emerging markets and hence demonstrates that international R&D activities not always evolve in a sequential and ordered trajectory....

Quantifying the effect of editor-author relations on manuscript handling times.

Science.gov (United States)

Sarigöl, Emre; Garcia, David; Scholtes, Ingo; Schweitzer, Frank

2017-01-01

In this article we study to what extent the academic peer review process is influenced by social relations between the authors of a manuscript and the editor handling the manuscript. Taking the open access journal PlosOne as a case study, our analysis is based on a data set of more than 100,000 articles published between 2007 and 2015. Using available data on handling editor, submission and acceptance time of manuscripts, we study the question whether co-authorship relations between authors and the handling editor affect the manuscript handling time , i.e. the time taken between the submission and acceptance of a manuscript. Our analysis reveals (1) that editors handle papers co-authored by previous collaborators significantly more often than expected at random, and (2) that such prior co-author relations are significantly related to faster manuscript handling. Addressing the question whether these shorter manuscript handling times can be explained by the quality of publications, we study the number of citations and downloads which accepted papers eventually accumulate. Moreover, we consider the influence of additional (social) factors, such as the editor's experience, the topical similarity between authors and editors, as well as reciprocal citation relations between authors and editors. Our findings show that, even when correcting for other factors like time, experience, and performance, prior co-authorship relations have a large and significant influence on manuscript handling times, speeding up the editorial decision on average by 19 days.

Design Concepts of Emergency Response Robot Platform K-R2D2

Energy Technology Data Exchange (ETDEWEB)

Noh, Sun Young; Jeong, Kyungmin [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

From the analysis for various mobile robots competed in DARPA Robotics Challenge, there are some drawbacks in using two or four legs because bipedal locomotion is not yet suitable for maintaining stability and quadrupedal locomotion is difficult to go through narrow aisles. Motivated by the above observations, we propose a K-R2D2 robot platform with three legs arranged in the form of a triangle like as R2-D2 robot which is a fictional robot character in the Star Wars movies. This robot has 3 legs with tracks in each sole of the leg. It is statically stable since there are three contact points to ground. In addition, three legs are also possible to design a structure walking stairs that can expand and contract in the vertical direction. This paper has presented the conceptual design, it is developed on the purpose of quick response instead of emergent workers to the extreme conditions disasters. This robot is emergency response robot platform KR2D2 with three legs, which is statically stable to walk or wheel depending on the terrains and move quickly as possible as on uneven terrain or stairs.

Design Concepts of Emergency Response Robot Platform K-R2D2

International Nuclear Information System (INIS)

Noh, Sun Young; Jeong, Kyungmin

2016-01-01

From the analysis for various mobile robots competed in DARPA Robotics Challenge, there are some drawbacks in using two or four legs because bipedal locomotion is not yet suitable for maintaining stability and quadrupedal locomotion is difficult to go through narrow aisles. Motivated by the above observations, we propose a K-R2D2 robot platform with three legs arranged in the form of a triangle like as R2-D2 robot which is a fictional robot character in the Star Wars movies. This robot has 3 legs with tracks in each sole of the leg. It is statically stable since there are three contact points to ground. In addition, three legs are also possible to design a structure walking stairs that can expand and contract in the vertical direction. This paper has presented the conceptual design, it is developed on the purpose of quick response instead of emergent workers to the extreme conditions disasters. This robot is emergency response robot platform KR2D2 with three legs, which is statically stable to walk or wheel depending on the terrains and move quickly as possible as on uneven terrain or stairs

[Regarding the Manuscript D " Dell' occhio " of Leonardo da Vinci].

Science.gov (United States)

Heitz, Robert F

2009-01-01

Leonardo da Vinci's Manuscript D consists of five double pages sheets, which, folded in two, comprise ten folios. This document, in the old Tuscan dialect and mirror writing, reveals the ideas of Leonardo on the anatomy of the eye in relation to the formation of images and visual perception. Leonardo explains in particular the behavior of the rays in the eye in terms of refraction and reflection, and is very mechanistic in his conception of the eye and of the visual process. The most significant innovations found in these folios are the concept of the eye as a camera obscura and the intersection of light rays in the interior of the eye. His texts nevertheless show hesitation, doubts and a troubled confusion, reflecting the ideas and uncertainties of his era. He did not share his results in his lifetime, despite both printing and etching being readily available to him.

UV-dependent production of 25-hydroxyvitamin D{sub 2} in the recombinant yeast cells expressing human CYP2R1

Energy Technology Data Exchange (ETDEWEB)

Yasuda, Kaori; Endo, Mariko; Ikushiro, Shinichi; Kamakura, Masaki [Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398 (Japan); Ohta, Miho [Department of Food and Nutrition Management Studies, Faculty of Human Development, Soai University, 4-4-1 Nanko-naka, Suminoe-ku, Osaka 559-0033 (Japan); Sakaki, Toshiyuki, E-mail: tsakaki@pu-toyama.ac.jp [Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398 (Japan)

2013-05-03

Highlights: •We produce 25-hydroxyvitamin D in the recombinant yeast expressing human CYP2R1. •Vitamin D2 is produced in yeast from endogenous ergosterol with UV irradiation. •We produce 25-hydroxyvitamin D2 in the recombinant yeast without added substrate. -- Abstract: CYP2R1 is known to be a physiologically important vitamin D 25-hydroxylase. We have successfully expressed human CYP2R1 in Saccharomyces cerevisiae to reveal its enzymatic properties. In this study, we examined production of 25-hydroxylated vitamin D using whole recombinant yeast cells that expressed CYP2R1. When vitamin D{sub 3} or vitamin D{sub 2} was added to the cell suspension of CYP2R1-expressing yeast cells in a buffer containing glucose and β-cyclodextrin, the vitamins were converted into their 25-hydroxylated products. Next, we irradiated the cell suspension with UVB and incubated at 37 °C. Surprisingly, the 25-hydroxy vitamin D{sub 2} was produced without additional vitamin D{sub 2}. Endogenous ergosterol was likely converted into vitamin D{sub 2} by UV irradiation and thermal isomerization, and then the resulting vitamin D{sub 2} was converted to 25-hydroxyvitamin D{sub 2} by CYP2R1. This novel method for producing 25-hydroxyvitamin D{sub 2} without a substrate could be useful for practical purposes.

Search for sharp and smooth spectral signatures of μνSSM gravitino dark matter with Fermi-LAT

Energy Technology Data Exchange (ETDEWEB)

Gómez-Vargas, Germán A. [Instituto de Astrofísica, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, Santiago (Chile); López-Fogliani, Daniel E.; Perez, Andres D. [Instituto de Física de Buenos Aires, UBA and CONICET, Departamento de Física, Facultad de Ciencia Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires (Argentina); Muñoz, Carlos [Departamento de Física Teórica, Universidad Autónoma de Madrid (UAM), Cantoblanco, 28049 Madrid (Spain); De Austri, Roberto Ruiz, E-mail: ggomezv@uc.cl, E-mail: daniel.lopez@df.uba.ar, E-mail: c.munoz@uam.es, E-mail: andres.perez@df.uba.ar, E-mail: rruiz@ific.uv.es [Instituto de Física Corpuscular CSIC-UV, c/Catedrático José Beltrán 2, 46980 Paterna (Valencia) (Spain)

2017-03-01

The μνSSM solves the μ problem of supersymmetric models and reproduces neutrino data, simply using couplings with right-handed neutrinos ν's. Given that these couplings break explicitly R parity, the gravitino is a natural candidate for decaying dark matter in the μνSSM. In this work we carry out a complete analysis of the detection of μνSSM gravitino dark matter through γ-ray observations. In addition to the two-body decay producing a sharp line, we include in the analysis the three-body decays producing a smooth spectral signature. We perform first a deep exploration of the low-energy parameter space of the μνSSM taking into account that neutrino data must be reproduced. Then, we compare the γ-ray fluxes predicted by the model with Fermi -LAT observations. In particular, with the 95% CL upper limits on the total diffuse extragalactic γ-ray background using 50 months of data, together with the upper limits on line emission from an updated analysis using 69.9 months of data. For standard values of bino and wino masses, gravitinos with masses larger than about 4 GeV, or lifetimes smaller than about 10{sup 28} s, produce too large fluxes and are excluded as dark matter candidates. However, when limiting scenarios with large and close values of the gaugino masses are considered, the constraints turn out to be less stringent, excluding masses larger than 17 GeV and lifetimes smaller than 4 × 10{sup 25} s.

Export performance and Investment in R&D

DEFF Research Database (Denmark)

Dilling-Hansen, Mogens; Madsen, Erik Strøjer; Schröder, Philipp

Export and R&D behavior are endogenous and interact in a non-trivial manner with each other. Subsequently an empirical model for export and R&D behavior is formulated taking account of, inter alia, firm size, wages, human capital and a number of other firm and industry specific factors...

SiGN-SSM: open source parallel software for estimating gene networks with state space models.

Science.gov (United States)

Tamada, Yoshinori; Yamaguchi, Rui; Imoto, Seiya; Hirose, Osamu; Yoshida, Ryo; Nagasaki, Masao; Miyano, Satoru

2011-04-15

SiGN-SSM is an open-source gene network estimation software able to run in parallel on PCs and massively parallel supercomputers. The software estimates a state space model (SSM), that is a statistical dynamic model suitable for analyzing short time and/or replicated time series gene expression profiles. SiGN-SSM implements a novel parameter constraint effective to stabilize the estimated models. Also, by using a supercomputer, it is able to determine the gene network structure by a statistical permutation test in a practical time. SiGN-SSM is applicable not only to analyzing temporal regulatory dependencies between genes, but also to extracting the differentially regulated genes from time series expression profiles. SiGN-SSM is distributed under GNU Affero General Public Licence (GNU AGPL) version 3 and can be downloaded at http://sign.hgc.jp/signssm/. The pre-compiled binaries for some architectures are available in addition to the source code. The pre-installed binaries are also available on the Human Genome Center supercomputer system. The online manual and the supplementary information of SiGN-SSM is available on our web site. tamada@ims.u-tokyo.ac.jp.

Implementation of 2D Discrete Wavelet Transform by Number Theoretic Transform and 2D Overlap-Save Method

Directory of Open Access Journals (Sweden)

Lina Yang

2014-01-01

Full Text Available To reduce the computation complexity of wavelet transform, this paper presents a novel approach to be implemented. It consists of two key techniques: (1 fast number theoretic transform(FNTT In the FNTT, linear convolution is replaced by the circular one. It can speed up the computation of 2D discrete wavelet transform. (2 In two-dimensional overlap-save method directly calculating the FNTT to the whole input sequence may meet two difficulties; namely, a big modulo obstructs the effective implementation of the FNTT and a long input sequence slows the computation of the FNTT down. To fight with such deficiencies, a new technique which is referred to as 2D overlap-save method is developed. Experiments have been conducted. The fast number theoretic transform and 2D overlap-method have been used to implement the dyadic wavelet transform and applied to contour extraction in pattern recognition.

Comparison of the uptake of [123/125I]-2-iodo-D-tyrosine and [123/125I]-2-iodo-L-tyrosine in R1M rhabdomyosarcoma cells in vitro and in R1M tumor-bearing Wag/Rij rats in vivo

International Nuclear Information System (INIS)

Bauwens, Matthias; Lahoutte, Tony; Kersemans, Ken; Gallez, Carol; Bossuyt, Axel; Mertens, John

2006-01-01

Introduction: Recently, promising results concerning uptake in vivo in tumors of D-amino acids have been published. Therefore, we decided to evaluate the tumor uptake of the D-analogue of [ 123 I]-2-iodo-L-tyrosine, a tracer recently introduced by our group into clinical trials. The uptake of 2-amino-3-(4-hydroxy-2-[ 123/125 I]iodophenyl)-D-propanoic acid (2-iodo-D-tyrosine) was studied in vitro in LAT1-expressing R1M rat rhabdomyosarcoma cells and in vivo in R1M tumor-bearing Wag/Rij rats. Methods: The uptake of [ 125 I]-2-iodo-L-tyrosine and [ 125 I]-2-iodo-D-tyrosine into R1M cells was determined in appropriate buffers, allowing the study of the involved transport systems. In vivo, the biodistribution in R1M-bearing rats of [ 123 I]-2-iodo-L-tyrosine and [ 123 I]-2-iodo-D-tyrosine was performed by both dynamic and static planar imaging with a gamma camera. Results: In in vitro conditions, the uptake of both [ 125 I]-2-iodo-L-tyrosine and [ 125 I]-2-iodo-D-tyrosine in the HEPES buffer was 25% higher in the presence of Na + ions. In the absence of Na + ions, [ 125 I]-2-iodo-D-tyrosine was taken up reversibly in the R1M cells, with an apparent accumulation, probably for the larger part by the LAT1 system. Dynamic planar imaging showed that the uptake in the tumors of [ 123 I]-2-iodo-D-tyrosine was somewhat lower than that of [ 123 I]-2-iodo-L-tyrosine. At 30 min postinjection, the mean differential uptake ratio values of the L- and D-enantiomers are 2.5±0.7 and 1.7±0.6, respectively. Although the uptake of the D-isomer is lower, probably due to a faster clearance from the blood, the tumor-background ratio is the same as that of the L-analogue. Conclusion: A large part (75%) of [ 125 I]-2-iodo-D-tyrosine in vitro and [ 123 I]-2-iodo-D-tyrosine in vivo is reversibly highly taken up in R1M tumor cells by Na + -independent LAT transport systems, more likely by the LAT1. The clearance from the blood of [ 123 I]-2-iodo-D-tyrosine in the rats is faster than that of the

Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes.

Science.gov (United States)

Borroto-Escuela, Dasiel O; Romero-Fernandez, Wilber; Narvaez, Manuel; Oflijan, Julia; Agnati, Luigi F; Fuxe, Kjell

2014-01-03

Dopamine D2LR-serotonin 5-HT2AR heteromers were demonstrated in HEK293 cells after cotransfection of the two receptors and shown to have bidirectional receptor-receptor interactions. In the current study the existence of D2L-5-HT2A heteroreceptor complexes was demonstrated also in discrete regions of the ventral and dorsal striatum with in situ proximity ligation assays (PLA). The hallucinogenic 5-HT2AR agonists LSD and DOI but not the standard 5-HT2AR agonist TCB2 and 5-HT significantly increased the density of D2like antagonist (3)H-raclopride binding sites and significantly reduced the pKiH values of the high affinity D2R agonist binding sites in (3)H-raclopride/DA competition experiments. Similar results were obtained in HEK293 cells and in ventral striatum. The effects of the hallucinogenic 5-HT2AR agonists on D2R density and affinity were blocked by the 5-HT2A antagonist ketanserin. In a forskolin-induced CRE-luciferase reporter gene assay using cotransfected but not D2R singly transfected HEK293 cells DOI and LSD but not TCB2 significantly enhanced the D2LR agonist quinpirole induced inhibition of CRE-luciferase activity. Haloperidol blocked the effects of both quinpirole alone and the enhancing actions of DOI and LSD while ketanserin only blocked the enhancing actions of DOI and LSD. The mechanism for the allosteric enhancement of the D2R protomer recognition and signalling observed is likely mediated by a biased agonist action of the hallucinogenic 5-HT2AR agonists at the orthosteric site of the 5-HT2AR protomer. This mechanism may contribute to the psychotic actions of LSD and DOI and the D2-5-HT2A heteroreceptor complex may thus be a target for the psychotic actions of hallunicogenic 5-HT2A agonists. Copyright © 2013 Elsevier Inc. All rights reserved.

Preparing a scientific manuscript in Linux: Today's possibilities and limitations.

Science.gov (United States)

Tchantchaleishvili, Vakhtang; Schmitto, Jan D

2011-10-22

Increasing number of scientists are enthusiastic about using free, open source software for their research purposes. Authors' specific goal was to examine whether a Linux-based operating system with open source software packages would allow to prepare a submission-ready scientific manuscript without the need to use the proprietary software. Preparation and editing of scientific manuscripts is possible using Linux and open source software. This letter to the editor describes key steps for preparation of a publication-ready scientific manuscript in a Linux-based operating system, as well as discusses the necessary software components. This manuscript was created using Linux and open source programs for Linux.

RSS SSM/I OCEAN PRODUCT GRIDS DAILY FROM DMSP F14 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids Daily from DMSP F14 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

RSS SSM/I OCEAN PRODUCT GRIDS DAILY FROM DMSP F11 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids Daily from DMSP F11 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

RSS SSM/I OCEAN PRODUCT GRIDS DAILY FROM DMSP F13 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids Daily from DMSP F13 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

Details for Manuscript Number SSM-D-06-01956R1 “Physicians” Communication and Perceptions of Patients: Is it How They Look, How They Talk, or is it Just the Doctor?”

Science.gov (United States)

Street, Richard L.; Gordon, Howard; Haidet, Paul

2010-01-01

Although physicians’ communication style and perceptions affect outcomes, few studies have examined how these perceptions relate to the way physicians communicate with patients. Moreover, while any number of factors may affect the communication process, few studies have analyzed these effects collectively in order to identify the most powerful influences on physician communication and perceptions. Adopting an ecological approach, this investigation examined: (a) the relationships of physicians’ patient-centered communication (informative, supportive, partnership-building) and affect (positive, contentious) on their perceptions of the patient, and (b) the degree to which communication and perceptions were affected by the physicians’ characteristics, patients’ demographic characteristics, physician-patient concordance, and the patient’s communication. Physicians (N = 29) and patients (N = 207) from 10 outpatient settings in the United States participated in the study. From audio-recordings of these visits, coders rated the physicians’ communication and affect as well as the patients’ participation and affect. Doctors were more patient-centered with patients they perceived as better communicators, more satisfied, and more likely to adhere. Physicians displayed more patient-centered communication and more favorably perceived patients who expressed positive affect, were more involved, and who were less contentious. Physicians were more contentious with black patients, whom they also perceived as less effective communicators and less satisfied. Finally, physicians who reported a patient-centered orientation to the doctor-patient relationship also were more patient-centered in their communication. The results suggest that reciprocity and mutual influence have a strong effect on these interactions in that more positive (or negative) communication from one participant leads to similar responses from the other. Physicians’ encounters with black patients

User interface design principles for the SSM/PMAD automated power system

Science.gov (United States)

Jakstas, Laura M.; Myers, Chris J.

1991-01-01

Martin Marietta has developed a user interface for the space station module power management and distribution (SSM/PMAD) automated power system testbed which provides human access to the functionality of the power system, as well as exemplifying current techniques in user interface design. The testbed user interface was designed to enable an engineer to operate the system easily without having significant knowledge of computer systems, as well as provide an environment in which the engineer can monitor and interact with the SSM/PMAD system hardware. The design of the interface supports a global view of the most important data from the various hardware and software components, as well as enabling the user to obtain additional or more detailed data when needed. The components and representations of the SSM/PMAD testbed user interface are examined. An engineer's interactions with the system are also described.

Evaluation of the Norwegian R&D Tax Credit Scheme

Directory of Open Access Journals (Sweden)

Ådne Cappelen

2010-11-01

Full Text Available We find that the Norwegian R&D tax credit scheme introduced in 2002 mainly works as intended. The scheme is cost-effective and it is used by a large number of firms. It stimulates these firms to invest more in R&D, and, in particular, the effect is positive for small firms with little R&D experience. The returns on the R&D investments supported by the scheme are positive and generally not different from the returns to other R&D investments. We have found examples of what can be interpreted as tax motivated adjustments to the scheme, but to some extent this must be accepted as a cost to subsidy and support schemes intended for use by a large number of economic agents. This is particularly so when attempts are made to keep administrative expenditures and control routines at a low level.

On the r-dynamic chromatic number of the corronation by complete graph

Science.gov (United States)

Indah Kristiana, Arika; Imam Utoyo, M.; Dafik

2018-04-01

In this paper we will study the r-dynamic chromatic number of the coronation by complete graph. A proper k-coloring of graph G such that the neighbors of any vertex v receive at least min{r, d(v)} different colors. The r-dynamic chromatic number, χ r (G) is the minimum k such that graph G has an r-dynamic k-coloring. We will obtain lower bound of the r-dynamic chromatic number of {χ }r({K}nȯ H), and {χ }r(Hȯ {K}m) We also study the exact value of the r-dynamic chromatic number of {χ }r({K}nȯ {S}m),{χ }r({K}nȯ {F}m),{χ }r({S}nȯ {K}m),{χ }r({F}nȯ {K}m) and {χ }r({K}nȯ {K}m) for m, n > 3.

Bibliometric Analysis of Manuscript Characteristics That Influence Citations: A Comparison of Six Major Radiology Journals.

Science.gov (United States)

Shekhani, Haris Naseem; Shariff, Shoaib; Bhulani, Nizar; Khosa, Faisal; Hanna, Tarek Noel

2017-12-01

The objective of our study was to investigate radiology manuscript characteristics that influence citation rate, capturing features of manuscript construction that are discrete from study design. Consecutive articles published from January 2004 to June 2004 were collected from the six major radiology journals with the highest impact factors: Radiology (impact factor, 5.076), Investigative Radiology (2.320), American Journal of Neuroradiology (AJNR) (2.384), RadioGraphics (2.494), European Radiology (2.364), and American Journal of Roentgenology (2.406). The citation count for these articles was retrieved from the Web of Science, and 29 article characteristics were tabulated manually. A point-biserial correlation, Spearman rank-order correlation, and multiple regression model were performed to predict citation number from the collected variables. A total of 703 articles-211 published in Radiology, 48 in Investigative Radiology, 106 in AJNR, 52 in RadioGraphics, 129 in European Radiology, and 157 in AJR-were evaluated. Punctuation was included in the title in 55% of the articles and had the highest statistically significant positive correlation to citation rate (point-biserial correlation coefficient [r pb ] = 0.85, p radiology. Using bibliometric knowledge, authors can craft a title, abstract, and text that may enhance visibility and citation count over what they would otherwise experience.

miR-30a suppresses osteosarcoma proliferation and metastasis by downregulating MEF2D expression

Directory of Open Access Journals (Sweden)

Du L

2018-04-01

Full Text Available Liuxue Du,* Tianpei Chen,* Kai Zhao,* Dong Yang Department of Orthopedics, the First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China *These authors contributed equally to this work Abstract: Many studies have revealed that microRNAs (miRNAs play crucial roles in cancer development and progression. miRNA-30a (miR-30a, as a member of the miR-30 family, has been implicated in various cancers. However, the role of miR-30a in osteosarcoma remains unclear. In the current study, we found that miR-30a was significantly downregulated in osteosarcoma tissues and cell lines by using quantitative real-time polymerase chain reaction (qRT-PCR. In addition, miR-30a could inhibit cancer cell growth, migration, and invasion in vitro. Furthermore, bioinformatics of miRNA target prediction and luciferase reporter assay indicated that MEF2D is a direct target of miR-30a. miR-30a was able to reduce the mRNA and protein expression of MEF2D as assessed using RT-PCR and Western blotting assay. Interestingly, overexpression of MEF2D partially reversed the miR-30a-reduced cell proliferation, migration, and invasion of osteosarcoma cell, indicating that miR-30a suppresses osteosarcoma cell proliferation and metastasis partially mediated by inhibition of MEF2D. Overall, our study demonstrated that miR-30a functions as a tumor suppressor by targeting MEF2D in osteosarcoma, providing a promising prognostic biomarker and a therapeutic strategy for osteosarcoma. Keywords: miR-30a, MEF2D, osteosarcoma, proliferation, invasion, migration

Startup, Shutdown, & Malfunction (SSM) Emissions at Industrial Facilities

Science.gov (United States)

EPA issued a final action to ensure states have plans in place that are fully consistent with the Clean Air Act and recent court decisions concerning startup, shutdown and malfunction (SSM) operations.

Hindrance of conservation biology by delays in the submission of manuscripts.

Science.gov (United States)

O'Donnell, Ryan P; Supp, Sarah R; Cobbold, Stephanie M

2010-04-01

Timely dissemination of scientific findings depends not only on rapid publication of submitted manuscripts, a topic which has received much discussion, but also on rapid submission of research after the research is completed. We measured submission delay (time from the last date of data collection to the submission of a manuscript) for every paper from 14 journals in 2007 and compared these submission delays among four fields of biology (conservation, taxonomy, behavior, and evolution). Manuscripts published in leading journals in the field of conservation biology have the longest delays in publication of accepted manuscripts and the longest intervals between completion of research and submission of the manuscript. Delay in manuscript submission accounts for more than half of the total time from last date of data collection to publication. Across fields, the number of authors was significantly negatively correlated with submission delay, but conservation journals had the second highest number of authors and the greatest submission delay, so submission of conservation manuscripts was not hindered by a shortage of collaboration relative to other fields. Rejection rates were greater in conservation journals than in behavior and evolution, but rejection times were faster; thus, there were no obvious net differences among fields in the time papers spent waiting to be rejected. Publication delay has been reduced significantly in the last 7 years, but was still greater in conservation journals than in any of the other three fields we studied. Thus, the urgent field of conservation biology is hindered in both preparation and publication of manuscripts.

32 CFR Appendix D to Part 623 - Certificate for Signature by an Alternate (DA Form 4881-1-R)

Science.gov (United States)

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Certificate for Signature by an Alternate (DA Form 4881-1-R) D Appendix D to Part 623 National Defense Department of Defense (Continued) DEPARTMENT...—Certificate for Signature by an Alternate (DA Form 4881-1-R) EC24OC91.019 EC24OC91.020 ...

Self-Invertible 2D Log-Gabor Wavelets

Czech Academy of Sciences Publication Activity Database

Fischer, S.; Šroubek, Filip; Perrinet, L.; Redondo, R.; Cristóbal, G.

2007-01-01

Roč. 75, č. 2 (2007), s. 231-246 ISSN 0920-5691 R&D Projects: GA ČR GA202/05/0242 Grant - others:GA MŠk(CZ) 2004CZ0009 Institutional research plan: CEZ:AV0Z10750506 Keywords : wavelet transforms * log-Gabor filters * oriented high-pass filters * image denoising Subject RIV: JD - Computer Applications, Robotics Impact factor: 3.381, year: 2007 http://staff.utia.cas.cz/sroubekf/papers/gabor_07.pdf

Critical issues facing R&D managers in China

NARCIS (Netherlands)

de Boer, S.J.; Gan, Weibing; Shan, Guogang

1998-01-01

R&D managers in China experienced significant changes in the past decade, in particular because of Government policies of economic reform and opening to the outside world. These developments have brought about a number of rather specific R&D management issues and problems. The paper addresses the

R&D Project Valuation Considering Changes of Economic Environment: A Case of a Pharmaceutical R&D Project

Directory of Open Access Journals (Sweden)

Jung Ho Park

2018-03-01

Full Text Available R&D project valuation is important for effective R&D portfolio management through decision making, related to the firm’s R&D productivity, sustainable management. In particular, scholars have emphasized the necessities of capturing option value in R&D and developed methods of real option valuation. However, despite suggesting various real option models, there are few studies on simultaneously employing mean-reverting stochastic process and Markov regime switching to describe the evolution of cash flow and to reflect time-varying parameters resulting from changes of economic environment. Therefore, we suggest a mean-reverting binomial lattice model under Markov regime switching and apply it to evaluate clinical development with project cases of the pharmaceutical industry. This study finds that decision making can be different according to the regime condition, thus the suggested model can capture risks caused by the uncertainty of the economic environment, represented by regime switching. Further, this study simulates the model according to rate parameter from 0.00 to 1.00 and risk-free interest rates for regimes 1 and 2 from ( r 1 = 4%, r 2 = 2% to ( r 1 = 7%, r 2 = 5%, and confirms the rigidity of the model. Therefore, in practice, the mean-reverting binomial lattice model under Markov regime switching proposed in this study for R&D project valuation contributes to assisting company R&D project managers make effective decision making considering current economic environment and future changes.

The use of soft system methodology (SSM) in a serviced-focussed study on the personal tutor's role.

Science.gov (United States)

Por, Jitna

2008-09-01

Soft system methodology (SSM) is described as a system-based methodology for tackling real world problems. SSM may be used as a means of articulating complex social processes in a particular way. SSM allows peoples' viewpoints and assumptions about the world to be bought to light, challenged and tested. This paper reports on the use of SSM in a service-focussed study (SFS) to explore the role of a personal tutor in nurse education. [Checkland, P., 1981. Systems Thinking Systems Practice. John Wiley and Sons, Chichester] highlighted the importance of considering cultural, social and political systems in the analysis. The seven stages of SSM are discussed in relation to the SFS and some of the findings are expressed through a 'Rich Picture'. It encourages commitment, brings diverse interests together and opens up the organizational culture. It also enables feasible and desirable changes to be recommended within the context of limited resources and competing demands upon lecturers' time. The SSM was an appropriate systematic model for this study and could be potentially useful in nurse education research.

3-D portal image analysis in clinical practice: an evaluation of 2-D and 3-D analysis techniques as applied to 30 prostate cancer patients

International Nuclear Information System (INIS)

Remeijer, Peter; Geerlof, Erik; Ploeger, Lennert; Gilhuijs, Kenneth; Herk, Marcel van; Lebesque, Joos V.

2000-01-01

Purpose: To investigate the clinical importance and feasibility of a 3-D portal image analysis method in comparison with a standard 2-D portal image analysis method for pelvic irradiation techniques. Methods and Materials: In this study, images of 30 patients who were treated for prostate cancer were used. A total of 837 imaged fields were analyzed by a single technologist, using automatic 2-D and 3-D techniques independently. Standard deviations (SDs) of the random, systematic, and overall variations, and the overall mean were calculated for the resulting data sets (2-D and 3-D), in the three principal directions (left-right [L-R], cranial-caudal [C-C], anterior-posterior [A-P]). The 3-D analysis included rotations as well. For the translational differences between the three data sets, the overall SD and overall mean were computed. The influence of out-of-plane rotations on the 2-D registration accuracy was determined by analyzing the difference between the 2-D and 3-D translation data as function of rotations. To assess the reliability of the 2-D and 3-D methods, the number of times the automatic match was manually adjusted was counted. Finally, an estimate of the workload was made. Results: The SDs of the random and systematic components of the rotations around the three orthogonal axes were 1.1 (L-R), 0.6 (C-C), 0.5 (A-P) and 0.9 (L-R), 0.6 (C-C), 0.8 (A-P) degrees, respectively. The overall mean rotation around the L-R axis was 0.7 deg., which deviated significantly from zero. Translational setup errors were comparable for 2-D and 3-D analysis (ranging from 1.4 to 2.2 mm SD and from 1.5 to 2.5 mm SD, respectively). The variation of the difference between the 2-D and 3-D translation data increased from 1.1 mm (SD) for zero rotations to 2.7 mm (SD) for out-of-plane rotations of 3 deg., due to a reduced 2-D registration accuracy for large rotations. The number of times the analysis was not considered acceptable and was manually adjusted was 44% for the 2-D

Export performance and investment in R&D

DEFF Research Database (Denmark)

Smith, Valdemar; Madsen, Erik Strøjer; Dilling-Hansen, Mogens

2002-01-01

This paper analyses the role of R&D in the export behaviour of Danish firms. Export behaviour is defined as the export intensity and the likelihood of a firm being an exporter. In the theoretical part of the paper it is argued that export and being R&D active are endogenous with respect to each...... other, and an empirical model is formulated in order to estimate which factors affect the firm's export. It is argued that besides R&D, firm size, wages and a number of other firm-specific factors controlling for risks are highly important for the export performance. In the empirical part of the paper...... the model is tested on a sample of 3,500 Danish firms. Using a FIML estimation form in order to deal with endogeneity problems between the R&D and export decisions of the firms, the computation clearly verifies the theoretical model put forward. Moreover, R&D is an important factor for being an exporting...

Do R&D Investments Affect Export Performance?

DEFF Research Database (Denmark)

Smith, Valdemar; Madsen, Erik Strøjer; Dilling-Hansen, Mogens

2002-01-01

This paper analyses the role of R&D in the export behaviour of Danish firms. Export behaviour is defined as the export intensity and the likelihood of a firm being an exporter. In the theoretical part of the paper it is argued that export and being R&D active are endogenous with respect to each...... other, and an empirical model is formulated in order to estimate which factors affect the firm's export. It is argued that besides R&D, firm size, wages and a number of other firm-specific factors controlling for risks are highly important for the export performance. In the empirical part of the paper...... the model is tested on a sample of 3,500 Danish firms. Using a FIML estimation form in order to deal with endogeneity problems between the R&D and export decisions of the firms, the computation clearly verifies the theoretical model put forward. Moreover, R&D is an important factor for being an exporting...

High glucose concentration induces endothelial cell proliferation by regulating cyclin-D2-related miR-98.

Science.gov (United States)

Li, Xin-Xin; Liu, Yue-Mei; Li, You-Jie; Xie, Ning; Yan, Yun-Fei; Chi, Yong-Liang; Zhou, Ling; Xie, Shu-Yang; Wang, Ping-Yu

2016-06-01

Cyclin D2 is involved in the pathology of vascular complications of type 2 diabetes mellitus (T2DM). This study investigated the role of cyclin-D2-regulated miRNAs in endothelial cell proliferation of T2DM. Results showed that higher glucose concentration (4.5 g/l) significantly promoted the proliferation of rat aortic endothelial cells (RAOECs), and significantly increased the expression of cyclin D2 and phosphorylation of retinoblastoma 1 (p-RB1) in RAOECs compared with those under low glucose concentration. The cyclin D2-3' untranslated region is targeted by miR-98, as demonstrated by miRNA analysis software. Western blot also confirmed that cyclin D2 and p-RB1 expression was regulated by miR-98. The results indicated that miR-98 treatment can induce RAOEC apoptosis. The suppression of RAOEC growth by miR-98 might be related to regulation of Bcl-2, Bax and Caspase 9 expression. Furthermore, the expression levels of miR-98 decreased in 4.5 g/l glucose-treated cells compared with those treated by low glucose concentration. Similarly, the expression of miR-98 significantly decreased in aortas of established streptozotocin (STZ)-induced diabetic rat model compared with that in control rats; but cyclin D2 and p-RB1 levels remarkably increased in aortas of STZ-induced diabetic rats compared with those in healthy control rats. In conclusion, this study demonstrated that high glucose concentration induces cyclin D2 up-regulation and miR-98 down-regulation in the RAOECs. By regulating cyclin D2, miR-98 can inhibit human endothelial cell growth, thereby providing novel therapeutic targets for vascular complication of T2DM. © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Changing R&D models in research-based pharmaceutical companies.

Science.gov (United States)

Schuhmacher, Alexander; Gassmann, Oliver; Hinder, Markus

2016-04-27

New drugs serving unmet medical needs are one of the key value drivers of research-based pharmaceutical companies. The efficiency of research and development (R&D), defined as the successful approval and launch of new medicines (output) in the rate of the monetary investments required for R&D (input), has declined since decades. We aimed to identify, analyze and describe the factors that impact the R&D efficiency. Based on publicly available information, we reviewed the R&D models of major research-based pharmaceutical companies and analyzed the key challenges and success factors of a sustainable R&D output. We calculated that the R&D efficiencies of major research-based pharmaceutical companies were in the range of USD 3.2-32.3 billion (2006-2014). As these numbers challenge the model of an innovation-driven pharmaceutical industry, we analyzed the concepts that companies are following to increase their R&D efficiencies: (A) Activities to reduce portfolio and project risk, (B) activities to reduce R&D costs, and (C) activities to increase the innovation potential. While category A comprises measures such as portfolio management and licensing, measures grouped in category B are outsourcing and risk-sharing in late-stage development. Companies made diverse steps to increase their innovation potential and open innovation, exemplified by open source, innovation centers, or crowdsourcing, plays a key role in doing so. In conclusion, research-based pharmaceutical companies need to be aware of the key factors, which impact the rate of innovation, R&D cost and probability of success. Depending on their company strategy and their R&D set-up they can opt for one of the following open innovators: knowledge creator, knowledge integrator or knowledge leverager.

Alteration of rRNA gene copy number and expression in patients ...

African Journals Online (AJOL)

Irina S. Kolesnikova

2017-09-01

Sep 1, 2017 ... Asia R. Shorina d, Alexander S. Graphodatsky a, Ekaterina M. Galanina b, Dmitry V. Yudkin a,b,* ... rRNA gene copy numbers on affected acrocentric chromosomes in .... estimated using MS Excel software (Microsoft, USA).

RSS SSM/I OCEAN PRODUCT GRIDS MONTHLY AVERAGE FROM DMSP F15 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids Monthly Average from DMSP F15 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special...

R&D Nuggets

Science.gov (United States)

RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About &D Nuggets Database dropdown arrow Search Tag Cloud Browse Reports Database Help Finding Aids

RSS SSM/I OCEAN PRODUCT GRIDS WEEKLY AVERAGE FROM DMSP F15 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids Weekly Average from DMSP F15 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

RSS SSM/I OCEAN PRODUCT GRIDS WEEKLY AVERAGE FROM DMSP F10 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids Weekly Average from DMSP F10 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

RSS SSM/I OCEAN PRODUCT GRIDS WEEKLY AVERAGE FROM DMSP F8 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Products Grid Weekly Average from DMSP F8 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

Outsourcing R&D

DEFF Research Database (Denmark)

Hsuan, Juliana; Mahnke, Volker

2011-01-01

Outsourcing R&D is an increasingly explored corporate practice. Extant research advanced our initial understanding of its increasing importance and benefits. While the associated literature has blossomed, the enthusiasm of R&D managers is tenured by an increasing realization of the possible......&D, suggest a simple, yet integrative model on the relation between outsourcing R&D and performance, and offer a research agenda that is instrumental in guiding companies’ process-management and design strategies when seeking to benefit from the outsourcing of R&D....

Study of X-ray transients with Scanning Sky Monitor (SSM) onboard ...

Indian Academy of Sciences (India)

M. C. RAMADEVI

MS received 1 September 2017; accepted 19 December 2017; published online 10 February 2018. Abstract. Scanning Sky Monitor (SSM) onboard AstroSat is an X-ray sky monitor in the ..... 31(2–3), 99. Ramadevi M. C., Seetha S., Babu V. C., Ashoka B. N., Sreeku- mar P. 2006, Optimization of Gas Proportional Coun-.

Project Selection for NASA's R&D Programs

Science.gov (United States)

Jones, Harry

2005-01-01

The purpose of NASA s Research and Development (R&D) programs is to provide advanced human support technologies for the Exploration Systems Mission Directorate (ESMD). The new technologies must be sufficiently attractive and proven to be selectable for future missions. This requires identifying promising candidate technologies and advancing them in technology readiness until they are likely options for flight. The R&D programs must select an array of technology development projects, manage them, and either terminate or continue them, so as to maximize the delivered number of potentially usable advanced human support technologies. This paper proposes an effective project selection methodology to help manage NASA R&D project portfolios.

Reliability Data Handbook for Piping Components in Nordic Nuclear Power Plants - R Book, Phase 2

International Nuclear Information System (INIS)

Hedtjaern Swaling, Vidar; Olsson, Anders

2011-02-01

This report presents results of a long research and development project financed by the regulatory body Straalsaekerhetsmyndigheten (SSM) (former SKI), the Swedish nuclear power plant licensees. The report presents a harmonized method for estimating Reliability Data for Piping Components in ASME code class 1 and 2 piping components (R-Book). Data in the R-Book is measured based on 'data driven' strategy. This first version of the R-Book comprises rupture frequencies and failure rates for all systems where ASME Code Class 1 or 2 events could be found in the OECD OPDE database. Nordic and Non-Nordic data are presented separately. Worldwide experience data is used to set up the relevant calculation cases, i.e. intersections of attributes for which there are at least one event present

Subsidizing R&D cooperatives

NARCIS (Netherlands)

Hinloopen, J.

2001-01-01

A framework is developed with which the implementation of two commonly used R&D-stimulating policies can be evaluated: providing R&D subsidies and sustaining the formation of R&D cooperatives. Subsidized R&D cooperatives can also be analyzed. The analysis shows that providing R&D subsidies is more

A note on duplication of R&D and R&D subsidies

OpenAIRE

Sami Dakhlia; Akram Temimi; Flavio Menezes

2004-01-01

We show that the presumed incompatibility of uncoordinated R&D and competition is not fundamental, but hinges on the nature of R&D spillovers. As a consequence, R&D subsidies may be more effective than previously thought.

Manuscript Cultures

DEFF Research Database (Denmark)

What do Mesoamerica, Greece, Byzantium, Island, Chad, Ethiopia, India, Tibet, China and Japan have in common? Like many other cultures of the world, they share a particular form of cultural heritage: ancient handwritten documents. In 2007, scholars from some20 countries around the world gathered...... at the University of Copenhagen for a workshop on manuscripts to compare notes. This event led to the publication of this volume, which brings together16 articles on philological, cultural, and material aspects of manuscripts in search for a common ground across disciplines and cultures....

A closer look at the R{sub D} and R{sub D{sup ∗}} anomalies

Energy Technology Data Exchange (ETDEWEB)

Bardhan, Debjyoti [Department of Theoretical Physics, Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Mumbai 400005 (India); Byakti, Pritibhajan [Department of Theoretical Physics, Indian Association for the Cultivation of Science,2A & 2B, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032 (India); Ghosh, Diptimoy [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot 76100 (Israel)

2017-01-27

The measurement of R{sub D} (R{sub D{sup ∗}}), the ratio of the branching fraction of B̄→Dτν̄{sub τ}(B̄→D{sup ∗}τν̄{sub τ}) to that of B̄→Dlν̄{sub l}(B̄→D{sup ∗}lν̄{sub l}), shows 1.9σ(3.3σ) deviation from its Standard Model (SM) prediction. The combined deviation is at the level of 4σ according to the Heavy Flavour Averaging Group (HFAG). In this paper, we perform an effective field theory analysis (at the dimension 6 level) of these potential New Physics (NP) signals assuming SU(3){sub C}×SU(2){sub L}×U(1){sub Y} gauge invariance. We first show that, in general, R{sub D} and R{sub D{sup ∗}} are theoretically independent observables and hence, their theoretical predictions are not correlated. We identify the operators that can explain the experimental measurements of R{sub D} and R{sub D{sup ∗}} individually and also together. Motivated by the recent measurement of the τ polarisation in B̄→D{sup ∗}τν̄{sub τ} decay, P{sub τ}(D{sup ∗}) by the Belle collaboration, we study the impact of a more precise measurement of P{sub τ}(D{sup ∗}) (and a measurement of P{sub τ}(D)) on the various possible NP explanations. Furthermore, we show that the measurement of R{sub D{sup ∗}} in bins of q{sup 2}, the square of the invariant mass of the lepton-neutrino system, along with the information on τ polarisation and the forward-backward asymmetry of the τ lepton, can completely distinguish the various operator structures. We also provide the full expressions of the double differential decay widths for the individual τ helicities in the presence of all the 10 dimension-6 operators that can contribute to these decays.

Petroleum R and D collaboration

International Nuclear Information System (INIS)

Kerr, R.

1995-01-01

Conditions for collaboration in research and development (R and D) were developed based on a decision-tree analysis. A key requirement for effective R and D collaboration was stated to be the company's ability to internalize a significant portion of the benefits. This was seen as the principal factor that determined good collaborators and good industries for collaboration. It was noted that collaboration benefits can also be improved through R and D exchanges in collaborative associations. Simple decision-tree analysis tended to understate the advantages of collaboration. Portfolio risk reduction and inter-project synergies were significant additional advantages. Collaborative R and D was said to be the preferred route for the development of a broad base of petroleum-related technologies. 5 tabs., 2 figs

MiR-519d-3p suppresses invasion and migration of trophoblast cells via targeting MMP-2.

Directory of Open Access Journals (Sweden)

Jie Ding

Full Text Available Our study was approved by the Medical Ethics Committee of Tang Du Hospital, Fourth Military Medical University and complied strictly with national ethical guidelines. Preeclampsia (PE is a specific clinical disorder characterized by gestational hypertension and proteinuria and is a leading cause of maternal and perinatal mortality worldwide. The miR-519d-3p is upregulated in the maternal plasma of patients with PE which indicates a possible association between this microRNA and the pathogenesis of PE. No studies to date have addressed the effect of miR-519d-3p on the invasion and migration of trophoblast cells. In our study, we found that miR-519d-3p expression was elevated in placental samples from patients with PE. In vitro, overexpression of miR-519d-3p significantly inhibited trophoblast cell migration and invasion, whereas transfection of a miR-519d-3p inhibitor enhanced trophoblast cell migration and invasion. Luciferase assays confirmed that matrix metalloproteinase-2 (MMP-2 is a direct target of miR-519d-3p. Quantitative real-time PCR and western blot assays showed that overexpression of miR-519d-3p downregulated MMP-2 mRNA and protein expression. Knockdown of MMP-2 using a siRNA attenuated the increased trophoblast migration and invasion promoted by the miR-519d-3p inhibitor. In placentas from patients with PE or normal pregnancies, a negative correlation between the expression of MMP-2 and miR-519d-3p was observed using the Pearson correlation and linear regression analysis. Our present findings suggest that upregulation of miR-519d-3p may contribute to the development of PE by inhibiting trophoblast cell migration and invasion via targeting MMP-2; miR-519d-3p may represent a potential predictive and therapeutic target for PE.

Pigment identification on medieval manuscripts, paintings and other artefacts by Raman microscopy: applications to the study of three German manuscripts

Science.gov (United States)

Burgio, Lucia; Ciomartan, Dan A.; Clark, Robin J. H.

1997-03-01

The identification of the pigments used to illuminate medieval manuscripts, paintings and other artefacts has received a major boost recently through perceptive studies carried out by Raman microscopy. A brief summary of the background of the technique is given. The results of studies on three illuminated German manuscripts are presented. The pigments vermilion HgS, iron oxide Fe 2O 3, azurite 2CuCO 3.Cu(OH) 2, malachite CuCo 3.Cu(OH) 2, lampblack (essentially carbon), white lead 2PbCO 3.Pb(OH) 2, lead tin yellow type I Pb 2SnO 4, and lazurite Na 8[Al 6Si 6O 24]S n (but only in admixture with Pb 2SnO 4, whereby it forms a green pigment), have been identified on these manuscripts on the basis of Raman microscopy and the results discussed.

40 CFR 63.2852 - What is a startup, shutdown, and malfunction plan?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What is a startup, shutdown, and... Production Compliance Requirements § 63.2852 What is a startup, shutdown, and malfunction plan? You must...)(2) malfunction period, or the § 63.2850(c)(2) or (d)(2) initial startup period. The SSM plan must...

International R&D Spillovers and Marginal Social Returns on R&D

NARCIS (Netherlands)

Sterken, Elmer; Ogawa, Kazuo; Tokutsu, Ichiro

2016-01-01

We analyze the impact of international R&D spillovers on recipient countries in terms of social and private returns. We divide the aggregate R&D stock by the business, government and education sectors and examine the impact on Total Factor Productivity. We endogenize the accrual of the R&D stocks by

Jawi Writing in Malay Archipelago Manuscript: A General Overview

Directory of Open Access Journals (Sweden)

Haji Harun Makmur

2018-01-01

Full Text Available Jawi writing is the main form of writing in various manuscripts recovered around the Archipelago, especially during the early arrival of Islam. These manuscripts are found to record history, art, culture, language, social, as well as ancient knowledge. The usage of Jawi writings had covered a number of calligraphy which are high in value with deep philosophical meaning, are full with creative notion as well as countless of patterns that went along with the call to Islam around the Archipelago in a relatively short period of time. The development of Jawi writing had been immortalized in various genres such as books, manuscripts and letters written by individual writers and in groups as a local way of living. This writing was also introduced through a long process using certain methods of writing and reading, and kept as individual as well as institutional collections all around the Archipelago. This article is focused in various manuscripts that not only were exclusively used as learning and teaching aids, but were also garnished as beautiful symbols and philosophical Islamic art that deserves a high degree of honour. This article’s objective is to deeply analyze the usage of this writing from manuscripts found around the Archipelago as a proof on the importance of this form of writing. The methodology of this article is library study, through a number of theories and methods. The implication of this article is hoped to form a certain standard as well as its own identity for the local society through their acceptance of this writing form, especially during the early arrival of Islam in the Archipelago thus deemed as a national treasure.

RSS SSM/I OCEAN PRODUCT GRIDS 3-DAY AVERAGE FROM DMSP F14 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids 3-Day Average from DMSP F14 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

RSS SSM/I OCEAN PRODUCT GRIDS 3-DAY AVERAGE FROM DMSP F10 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids 3-Day Average from DMSP F10 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

Fully digital 1-D, 2-D and 3-D multiscroll chaos as hardware pseudo random number generators

KAUST Repository

Mansingka, Abhinav S.

2012-10-07

This paper introduces the first fully digital implementation of 1-D, 2-D and 3-D multiscroll chaos using the sawtooth nonlinearity in a 3rd order ODE with the Euler approximation. Systems indicate chaotic behaviour through phase space boundedness and positive Lyapunov exponent. Low-significance bits form a PRNG and pass all tests in the NIST SP. 800-22 suite without post-processing. Real-time control of the number of scrolls allows distinct output streams with 2-D and 3-D multiscroll chaos enabling greater controllability. The proposed PRNGs are experimentally verified on a Xilinx Virtex 4 FPGA with logic utilization less than 1.25%, throughput up to 5.25 Gbits/s and up to 512 distinct output streams with low cross-correlation.

Characterization of surface liquid segregation in SSM-HPDC aluminium alloys 7075, 2024, 6082 and A201

CSIR Research Space (South Africa)

Moller, H

2010-09-01

Full Text Available Semi-solid metal (SSM) processing is a unique manufacturing method to produce near-net shape products for various industrial applications. The nature of the SSM slurry (with solid spherical grains suspended in a liquid), makes it susceptible...

Soma, food of the immortals according to the Bower Manuscript (Kashmir, 6th century A.D.).

Science.gov (United States)

Leonti, Marco; Casu, Laura

2014-08-08

Food is medicine and vice versa. In Hindu and Ayurvedic medicine, and among human cultures of the Indian subcontinent in general, the perception of the food-medicine continuum is especially well established. The preparation of the exhilarating, gold-coloured Soma, Amrita or Ambrosia, the elixir and food of the 'immortals'-the Hindu pantheon-by the ancient Indo-Aryans, is described in the Rigveda in poetic hymns. Different theories regarding the botanical identity of Soma circulate, but no pharmacologically and historically convincing theory exists to date. We intend to contribute to the botanical, chemical and pharmacological characterisation of Soma through an analysis of two historical Amrita recipes recorded in the Bower Manuscript. The recipes are referred therein as panaceas (clarified butter) and also as a medicine to treat nervous diseases (oil), while no exhilarating properties are mentioned. Notwithstanding this, we hypothesise, that these recipes are related to the ca. 1800 years older Rigvedic Soma. We suppose that the psychoactive Soma ingredient(s) are among the components, possibly in smaller proportions, of the Amrita recipes preserved in the Bower Manuscript. The Bower Manuscript is a medical treatise recorded in the 6th century A.D. in Sanskrit on birch bark leaves, probably by Buddhist monks, and unearthed towards the end of the 19th century in Chinese Turkestan. We analysed two Amrita recipes from the Bower Manuscript, which was translated by Rudolf Hoernle into English during the early 20th century. A database search with the updated Latin binomials of the herbal ingredients was used to gather quantitative phytochemical and pharmacological information. Together, both Amrita recipes contain around 100 herbal ingredients. Psychoactive alkaloid containing species still important in Ayurvedic, Chinese and Thai medicine and mentioned in the recipe for 'Amrita-Prâsa clarified butter' and 'Amrita Oil' are: Tinospora cordifolia (Amrita, Guduchi), three

Several classes of graphs and their r-dynamic chromatic numbers

Science.gov (United States)

Dafik; Meganingtyas, D. E. W.; Dwidja Purnomo, K.; Dicky Tarmidzi, M.; Hesti Agustin, Ika

2017-06-01

Let G be a simple, connected and undirected graph. Let r, k be natural numbers. By a proper k-coloring of a graph G, we mean a map c : V (G) → S, where |S| = k, such that any two adjacent vertices receive different colors. An r-dynamic k-coloring is a proper k-coloring c of G such that |c(N(v))| ≥ min{r, d(v)} for each vertex v in V (G), where N(v) is the neighborhood of v and c(S) = {c(v) : v ∈ S} for a vertex subset S. The r-dynamic chromatic number, written as χ r (G), is the minimum k such that G has an r-dynamic k-coloring. By simple observation it is easy to see that χ r (G) ≤ χ r+1(G), however χ r+1(G) - χ r (G) does not always show a small difference for any r. Thus, finding an exact value of χ r (G) is significantly useful. In this paper, we will study some of them especially when G are prism graph, three-cyclical ladder graph, joint graph and circulant graph.

R&D 100 Awards | NREL

Science.gov (United States)

R&D 100 Awards R&D 100 Awards NREL has won 61 R&D 100 Awards. Widely recognized as the Oscars of Invention, the R&D 100 Awards are presented by R&D Magazine to identify and celebrate the top technological advances of the year. Recent R&D 100 Awards 2016 NREL engineers Chuck Booten

Energy R and D in Japan; TOPICAL

International Nuclear Information System (INIS)

J.J. Dooley

1999-01-01

In 1997, the public and private sectors in Japan invested$90.3 billion in R and D. Japan is the second largest supporter of R and D after the United States. A very large percentage (79.4%) of all R and D in Japan is supported by the private sector. The prolonged economic recession that has plagued the Japanese economy for most of the 1990s has significantly reduced the scale of the Japanese R and D effort compared to what it would have been had the economy been more robust. The Japanese government has recently attempted to bring the economy out of this recession through the use of economic stimulus packages. These stimulus packages have contained significant new funding for R and D, although it is apparent that much of the funding is going to R and D programs and R and D construction projects with very near tern payoff and not to the support of longer term R and D. In 1998, the Japanese government devoted 13.7% of all public R and D funds to the support of energy R and D. The priority accorded to energy R and D in Japan is significantly higher than in any other industrialized nation. The Japanese energy R and D program, which was funded at$2.5 billion in 1997, is overwhelmingly focused on nuclear energy R and D. Nuclear energy R and D (fission and fusion) accounts for 75% of the total national energy R and D budget. The fission energy R and D effort has decreased nearly 24% since 1996 as the government attempts to refocus this program in the face of growing public opposition to the Japanese government's efforts to expand the nuclear power program. Energy efficiency R and D (8% of the total national energy R and D budget) and renewable energy R and D receive relatively modest support from the Japanese government

SSM's licensing review of a spent nuclear fuel repository in Sweden

International Nuclear Information System (INIS)

Dverstorpand, Bjoern; Stroemberg, Bo

2014-01-01

On 16 March 2011 the Swedish Nuclear Fuel and Waste Management Co. (SKB) submitted license applications for a general license to construct, possess and operate a KBS-3 type spent nuclear fuel repository at the Forsmark site, in Oesthammar municipality, and an encapsulation plant in Oskarshamn municipality. The KBS-3 method, which has been developed by SKB over a period of more than 30 years, entails disposing of the spent fuel in copper canisters, surrounded by a swelling bentonite clay, at about 500 m depth in crystalline basement rock. SKB's applications are being evaluated in parallel by the Swedish Radiation Safety Authority (SSM) according to the Act on Nuclear Activities and by the Land and Environmental Court according to the Environmental Code. During the review SSM will act as an expert review body to the Land and Environmental Court in the areas of radiation protection, safety and security/non-proliferation. Both SSM and the court will produce a statement with a recommendation regarding a licensing decision and licensing conditions to the government. The government will make the final decision after consulting the municipalities concerned by SKB's facilities (municipal veto applies). The current licensing decision is just one of several licensing decisions that will be required for the repository. However it is arguably the most important one, because it is the last licensing stage with a broad societal involvement including an environmental impact assessment (EIA) process, national consultations and municipal veto for the concerned municipalities. The licensing steps to follow, should SKB be granted a license by the government, only require approval by SSM. These steps include application for start of actual construction work, test operation and routine operation. (authors)

Big Pharma, little science? A bibliometric perspective on Big Pharma's R&D decline

NARCIS (Netherlands)

Rafols, Ismael; Hopkins, Michael M.; Hoekman, Jarno; Siepel, Josh; O'Hare, Alice; Perianes-Rodriguez, Antonio; Nightingale, Paul

There is a widespread perception that pharmaceutical R&D is facing a productivity crisis characterised by stagnation in the numbers of new drug approvals in the face of increasing R&D costs. This study explores pharmaceutical R&D dynamics by examining the publication activities of all R&D

Gclust Server: 36736 [Gclust Server

Lifescience Database Archive (English)

Full Text Available 36736 Rhe_RHE_CH01092 Cluster Sequences - 156 putative terminase small subunit prot...ein 3 1.00e-60 0.0 0.0 0.0 0.0 6.45 0.0 Show 36736 Cluster ID 36736 Sequence ID Rhe_RHE_CH01092 Link to clus

Multiscale Pigment Analysis of Medieval Illuminated Manuscripts

Science.gov (United States)

Sestak, Erica; Manukyan, Khachatur; Wiescher, Michael; Gura, David

2017-09-01

Three medieval illuminated manuscripts (codd. Lat. b. 1; Lat. b. 2; Lat. e. 4), housed at the University of Notre Dame's Hesburgh Library, vary in style, pigments, scribes, and regions, despite all three being Psalters used in the Late Middle Ages. XRF and Raman spectroscopy, which provided the elemental and molecular composition of the pigments, respectively, were used to analyze the pigments' compositions in an attempt to narrow further the manuscripts' possible origins. This experimental investigation emphasizes the importance of understanding the history of the manuscript through their pigments. Codd. Lat. b. 1 and Lat. b. 2 are Latinate German Psalters from the fifteenth century likely used in Katharinenkloster in Nuremberg. While there are visible differences in style within each Psalter, the variations in some of the pigment compositions, such as the inconstant presence of zinc, suggest different admixtures. Cod. Lat. e. 4 is a Latinate English Psalter from the fourteenth century, and it was written by two scribes and illuminated by two distinct painters. It is currently being tested to determine whether there are any correlations between the scribes and painters. These physical analyses will clarify the origins and provenances of the manuscripts.

Offshoring R&D

DEFF Research Database (Denmark)

Hansen, Zaza Nadja Lee; Rasmussen, Lauge Baungaard

2010-01-01

Companies are increasingly offshoring R&D activities. Many firms, however, experience difficulties related to virtual teamwork across cultures and time zones. The research question is: How does increasing R&D offshoring impact transparency of communication structures and knowledge sharing? Using...... case studies from Danish multinational corporations with R&D activities in China, India or Eastern Europe this paper analyses the impact observed in these companies in regard to communication structures and knowledge sharing in management of offshored R&D activities. The findings show that companies...... attempt to increase transparency through formalisation of knowledge and clear communication structures. However, the influence of tacit knowledge, horizontal communication and culture seem largely overlooked. Therefore the authors suggest a context based approach to transparency accustomed...

On medieval manuscript production in the Latin West, explorations with a global database

NARCIS (Netherlands)

Buringh, E.

2009-01-01

This study is the first to present detailed information on the production and uses of manuscripts in eleven geographical areas, together comprising the Latin West. We estimated the absolute production (in numbers of manuscripts copied per century) in Europe between 500 and 1500. In total some eleven

Generalized r-Lah numbers

Indian Academy of Sciences (India)

016-0309-0. Generalized r-Lah numbers. MARK SHATTUCK. Department of ...... of Dowling lattices, Discrete Math. 312. (2012) 2337–2348. [7] Hsu L C and Shiue P J-S, A unified approach to generalized Stirling numbers, Adv. Appl. Math.

Integrality of the monopole number in SU(2) Yang-Mills-Higgs theory on R3

International Nuclear Information System (INIS)

Groisser, D.

1984-01-01

We prove that in classical SU(2) Yang-Mills-Higgs theories on R 3 with a Higgs field in the adjoint representation, an integer-valued monopole number (magnetic charge) is canonically defined for any finite-action L 2 sub(1,loc) configuration. In particular the result is true for smooth configurations. The monopole number is shown to decompose the configuration space into path components. (orig.)

Energy R and D in Germany

Energy Technology Data Exchange (ETDEWEB)

Runci, PJ

1999-11-01

Germany's total national (i.e., combined public and private sector) funding for R&D stood at $42 billion in 1997. The private sector accounted for nearly 62% ($24 billion) of the total, while the public sector accounted for approximately 38%. Since the late 1970s, when the public and private sectors each funded roughly half of Germany's R&D, the private sector has steadily assumed a larger and larger role as the dominant supporter of R&D activity, while overall government funding has remained essentially flat for much of the past two decades. In addition to declining relative to private R&D expenditures, public R&D expenditures in Germany declined by 4% in real terms between 1991 and 1997, to approximately $15 billion. The reduction in R&D investments in the public sector can be attributed in large part to the financial challenges associated with German reunification and related shifts in social priorities including efforts to address high unemployment and to rebuild basic infrastructure in the eastern states. R&D expenditures have also declined as a percentage of the total public budget, from a peak of 3.4% in 1985 to 2.7% in 1996. Energy R&D has been the hardest hit of all major socioeconomic areas of R&D expenditure funded by the German government. Between 1981 and 1997, public energy R&D fell from approximately $1.6 billion to $400 million--a 75% real decline. The $850 million reduction in Germany's fission R&D budget (which constituted two-thirds of government R&D investment in 1985) explains some 90% of the funding decline. Negative public perceptions regarding the safety and environmental impacts of nuclear energy have reduced nuclear power's viability as a long-term energy option for Germany. Discussions of a complete nuclear phaseout are now under way. At the same time, the German government has slashed its investments in fossil energy R&D by more than 90%. While energy efficiency and renewable energy technologies have fared relatively well in comparison

Print and Manuscript

OpenAIRE

Erne, Lukas Christian

2007-01-01

Positioning Shakespeare at the "crossroads of manuscript and print" and exploring what the choice of print or manuscript reveals about the poet's intended audience and the social persona the poet wanted to assume and fashion, argues that "Shakespeare's authorial self-presentation begins as a poet and, more specifically, as a print-published poet" with the publication of Venus and Adonis in 1593 and the allusion to the publication of Rape of Lucrece in the next year. Yet also considers the imp...

Fields of application of SSM : a categorization of publications

NARCIS (Netherlands)

de Water, H. van; Schinkel, M.; Rozier, R.

In this article, we introduce a classification scheme for publications of articles on SSM. Generally speaking, the publications can be divided into empirically orientated and theoretically orientated papers. Within each of these two categories a further subdivision is made. This subdivision consists

Recognition for old Arabic manuscripts using spatial gray level dependence (SGLD

Directory of Open Access Journals (Sweden)

Ahmad M. Abd Al-Aziz

2011-03-01

Full Text Available Texture analysis forms the basis of object recognition and classification in several domains, one of these domains is historical document manuscripts because the manuscripts hold our culture heritage and also large numbers of undated manuscripts exist. This paper presents results for historical document classification of old Arabic manuscripts using texture analysis and a segmentation free approach. The main objective is to discriminate between historical documents of different writing styles to three different ages: Contemporary (Modern Age, Ottoman Age and Mamluk Age. This classification depends on a Spatial Gray-level Dependence (SGLD technique which provides eight distinct texture features for each sample document. We applied Stepwise Discriminant Analysis and Multiple discriminant analysis methods to decrease the dimensionality of features and extract training vector features from samples. To classify historical documents into three main historical age classes the decision tree classification is applied. The system has been tested on 48 Arabic historical manuscripts documents from the Dar Al-Kotob Al-Masria Library. Our results so far yield 95.83% correct classification for the historical Arabic documents.

Fate of manuscripts rejected by a non-English-language general medical journal

DEFF Research Database (Denmark)

Vinther, Siri; Rosenberg, Jacob

2011-01-01

Objective The objective of this study was to determine whether, where and when manuscripts were published following rejection by the Journal of the Danish Medical Association, a general medical journal published in Danish. Similar previous studies have focused on specialty/subspecialty journals...... evaluated. Results Of 198 rejected manuscripts, 21 (10.6%) were eventually published after a median of 685 days (range 209-1463). The majority of these were original research, published in English-language specialty/subspecialty journals. The median number of citations per article was 2-3 (IQR 0...... translation could be a barrier for resubmitting to English-language journals with larger readerships, thus hindering the dissemination of knowledge to the international community....

Degenerate r-Stirling Numbers and r-Bell Polynomials

Science.gov (United States)

Kim, T.; Yao, Y.; Kim, D. S.; Jang, G.-W.

2018-01-01

The purpose of this paper is to exploit umbral calculus in order to derive some properties, recurrence relations, and identities related to the degenerate r-Stirling numbers of the second kind and the degenerate r-Bell polynomials. Especially, we will express the degenerate r-Bell polynomials as linear combinations of many well-known families of special polynomials.

Enhanced Geothermal Systems (EGS) R&D Program

Energy Technology Data Exchange (ETDEWEB)

Entingh, Daniel J.

1999-08-18

The purpose of this workshop was to develop technical background facts necessary for planning continued research and development of Enhanced Geothermal Systems (EGS). EGS are geothermal reservoirs that require improvement of their permeability or fluid contents in order to achieve economic energy production. The initial focus of this R&D program is devising and testing means to extract additional economic energy from marginal volumes of hydrothermal reservoirs that are already producing commercial energy. By mid-1999, the evolution of the EGS R&D Program, begun in FY 1988 by the U.S. Department of Energy (DOE), reached the stage where considerable expertise had to be brought to bear on what technical goals should be pursued. The main purpose of this Workshop was to do that. The Workshop was sponsored by the Office of Geothermal Technologies of the Department of Energy. Its purpose and timing were endorsed by the EGS National Coordinating Committee, through which the EGS R&D Program receives guidance from members of the U.S. geothermal industry. Section 1.0 of this report documents the EGS R&D Program Review Session. There, managers and researchers described the goals and activities of the program. Recent experience with injection at The Geysers and analysis of downhole conditions at Dixie Valley highlighted this session. Section 2.0 contains a number of technical presentations that were invited or volunteered to illuminate important technical and economic facts and opportunities for research. The emphasis here was on fi.acture creation, detection, and analysis. Section 3.0 documents the initial general discussions of the participants. Important topics that emerged were: Specificity of defined projects, Optimizing cost effectiveness, Main technical areas to work on, Overlaps between EGS and Reservoir Technology R&D areas, Relationship of microseismic events to hydraulic fractures, and Defining criteria for prioritizing research thrusts. Sections 4.0 and 5.0 report

Integration of μ-XRF, and u-Raman techniques to study ancient Islamic manuscripts

International Nuclear Information System (INIS)

Hamdan, N M; Alawadhi, H; Jisrawi, N

2012-01-01

Systematic characterizations of inks used in three ancient Arabic manuscripts were performed using energy dispersive X-ray fluorescence (EDXRF) and RAMAN spectroscopy. Spatially resolved element distributions obtained by area scans in addition to spot analysis provided detailed information about the manuscripts. RAMAN spectroscopy, on the other hand provided decisive information about the compounds used in various color pigments. Different compounds were found in the red ink in each manuscript: HgS (cinnabar) in one manuscript, red lead Pb 3 0 4 (minium) in the second, and a mixture of the two in the third manuscript. The green pigment was Cu based and it is probably malachite (Cu 2 CO 3 (OH) 2 ), while the black ink pigment in the three manuscripts is iron gall (Fe 2 SO 4 plus gallottanic acid). Analytical results and the context of the manuscripts were used to extract information about the authenticity and origin of the manuscripts. For example, the use of cinnabar as a red ink pigment found in the third manuscript reveals that this manuscript attributed to Al-Gazali (11 th century) is probably a copy from a later period, because cinnabar was first introduced in the 16th century.

Rényi entropies and topological quantum numbers in 2D gapped Dirac materials

International Nuclear Information System (INIS)

Bolívar, Juan Carlos; Romera, Elvira

2017-01-01

New topological quantum numbers are introduced by analyzing complexity measures and relative Rényi entropies in silicene in the presence of perpendicular electric and magnetic fields. These topological quantum numbers characterize the topological insulator and band insulator phases in silicene. In addition, we have found that, these information measures reach extremum values at the charge neutrality points. These results are valid for other 2D gapped Dirac materials analogous to silicene with a buckled honeycomb structure and a significant spin-orbit coupling. - Highlights: • Topological quantum numbers (Chern-like numbers) by Rényi entropies in silicene. • These topological numbers characterize silicene topological and band insulator phases. • These information measures reach extremum values at the charge neutrality points. • These results are valid for other 2D gapped Dirac materials analogous to silicene.

The Idea of an Old Qur'an Manuscript: On the Commercialization of the Indonesian Islamic Heritage

Directory of Open Access Journals (Sweden)

Edwin Wieringa

2015-02-01

Full Text Available A Qur’an manuscript, now in the possession of the University of Cologne, Germany (call number Cod. Malaiologie 001/2012, can be regarded as a “fake” in the sense of having a misleading appearance. This manuscript is a fairly recent bricolage which aims to represent the idea of an old Qur’an manuscript, thereby catering to the increased demand on the international market for old manuscripts from insular Southeast Asia.

Gender trends of urology manuscript authors in the United States: a 35-year progression.

Science.gov (United States)

Weiss, Dana A; Kovshilovskaya, Bogdana; Breyer, Benjamin N

2012-01-01

The presence of women in urology has gradually increased in the last 35 years with an accelerated rate in the last decade. We evaluated manuscript authorship trends by gender. Manuscript authorship is a metric that has been used as a marker of academic productivity. We hypothesized that the number of first and last author publications by women has increased proportionately to the number of women in the field during the last 35 years. We performed a bibliometric study to examine authorship gender in The Journal of Urology® and Urology®. We reviewed all original articles published from American institutions in 1974, 1979, 1984, 1989, 1994, 1999, 2004 and 2009. Of the 8,313 articles reviewed 5,461 were from American institutions, including 97.5% for which we determined author gender. There were 767 articles with female authors, including 440 first and 327 last authors. First and last female authorship increased from 2.7% of all authors in 1979 to 26.5% in 2009 (test for trend p authorship rate surpasses the rate of growth of women in urology, which increased from 0.24% in 1975 to 6.2% in 2008. Based on authorship gender analysis women urologists produce manuscripts at a rate that exceeds their number in the field. Findings show that women in urology are productive, active members of the academic community. Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Sampling Number Effects in 2D and Range Imaging of Range-gated Acquisition

International Nuclear Information System (INIS)

Kwon, Seong-Ouk; Park, Seung-Kyu; Baik, Sung-Hoon; Cho, Jai-Wan; Jeong, Kyung-Min

2015-01-01

In this paper, we analyzed the number effects of sampling images for making a 2D image and a range image from acquired RGI images. We analyzed the number effects of RGI images for making a 2D image and a range image using a RGI vision system. As the results, 2D image quality was not much depended on the number of sampling images but on how much well extract efficient RGI images. But, the number of RGI images was important for making a range image because range image quality was proportional to the number of RGI images. Image acquiring in a monitoring area of nuclear industry is an important function for safety inspection and preparing appropriate control plans. To overcome the non-visualization problem caused by airborne obstacle particles, vision systems should have extra-functions, such as active illumination lightening through disturbance airborne particles. One of these powerful active vision systems is a range-gated imaging system. The vision system based on the range-gated imaging system can acquire image data from raining or smoking environments. Range-gated imaging (RGI) is a direct active visualization technique using a highly sensitive image sensor and a high intensity illuminant. Currently, the range-gated imaging technique providing 2D and 3D images is one of emerging active vision technologies. The range-gated imaging system gets vision information by summing time sliced vision images. In the RGI system, a high intensity illuminant illuminates for ultra-short time and a highly sensitive image sensor is gated by ultra-short exposure time to only get the illumination light. Here, the illuminant illuminates objects by flashing strong light through airborne disturbance particles. Thus, in contrast to passive conventional vision systems, the RGI active vision technology robust for low-visibility environments

Sampling Number Effects in 2D and Range Imaging of Range-gated Acquisition

Energy Technology Data Exchange (ETDEWEB)

Kwon, Seong-Ouk; Park, Seung-Kyu; Baik, Sung-Hoon; Cho, Jai-Wan; Jeong, Kyung-Min [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-10-15

In this paper, we analyzed the number effects of sampling images for making a 2D image and a range image from acquired RGI images. We analyzed the number effects of RGI images for making a 2D image and a range image using a RGI vision system. As the results, 2D image quality was not much depended on the number of sampling images but on how much well extract efficient RGI images. But, the number of RGI images was important for making a range image because range image quality was proportional to the number of RGI images. Image acquiring in a monitoring area of nuclear industry is an important function for safety inspection and preparing appropriate control plans. To overcome the non-visualization problem caused by airborne obstacle particles, vision systems should have extra-functions, such as active illumination lightening through disturbance airborne particles. One of these powerful active vision systems is a range-gated imaging system. The vision system based on the range-gated imaging system can acquire image data from raining or smoking environments. Range-gated imaging (RGI) is a direct active visualization technique using a highly sensitive image sensor and a high intensity illuminant. Currently, the range-gated imaging technique providing 2D and 3D images is one of emerging active vision technologies. The range-gated imaging system gets vision information by summing time sliced vision images. In the RGI system, a high intensity illuminant illuminates for ultra-short time and a highly sensitive image sensor is gated by ultra-short exposure time to only get the illumination light. Here, the illuminant illuminates objects by flashing strong light through airborne disturbance particles. Thus, in contrast to passive conventional vision systems, the RGI active vision technology robust for low-visibility environments.

D R Choudhari

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. D R Choudhari. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 11 November 1998 pp 94-95 Book Review. Linear Algebra · D R Choudhari · More Details Fulltext PDF ...

Distributed R and D. Inside the Black Box

DEFF Research Database (Denmark)

Pedersen, Jørgen Lindgaard

2006-01-01

During the last few decades business R and D has changed from beeing an in-house activity to beeing an activty offshored, outsourced or made as joint venture with other other companies or R and D institutions. Gerybadze and Reger has in an article (Recent Changes in the Management of Innovation...... in Transnational Corporations, Research Policy 28, issue 2-3, pp. 252-274, 1999)stressed the existence of two different trends in R&D locations: 1)An on-going process with setting up R&D laboratories and product development activities in different places in the world, and 2)An even more consistent concentration...... as an outsourcing.In hearing aid industry nearly nothing in R&D has been moved out from companies. Something like clinical tests are made in cooperation with hospitals or clinics. In enzymes some R and D activites are offshored. According to informations from companies there are no disasters but in some cases...

WE-AB-BRA-07: Quantitative Evaluation of 2D-2D and 2D-3D Image Guided Radiation Therapy for Clinical Trial Credentialing, NRG Oncology/RTOG

Energy Technology Data Exchange (ETDEWEB)

Giaddui, T; Yu, J; Xiao, Y [Thomas Jefferson University, Philadelphia, PA (United States); Jacobs, P [MIM Software, Inc, Cleavland, Ohio (United States); Manfredi, D; Linnemann, N [IROC Philadelphia, RTQA Center, Philadelphia, PA (United States)

2015-06-15

Purpose: 2D-2D kV image guided radiation therapy (IGRT) credentialing evaluation for clinical trial qualification was historically qualitative through submitting screen captures of the fusion process. However, as quantitative DICOM 2D-2D and 2D-3D image registration tools are implemented in clinical practice for better precision, especially in centers that treat patients with protons, better IGRT credentialing techniques are needed. The aim of this work is to establish methodologies for quantitatively reviewing IGRT submissions based on DICOM 2D-2D and 2D-3D image registration and to test the methodologies in reviewing 2D-2D and 2D-3D IGRT submissions for RTOG/NRG Oncology clinical trials qualifications. Methods: DICOM 2D-2D and 2D-3D automated and manual image registration have been tested using the Harmony tool in MIM software. 2D kV orthogonal portal images are fused with the reference digital reconstructed radiographs (DRR) in the 2D-2D registration while the 2D portal images are fused with DICOM planning CT image in the 2D-3D registration. The Harmony tool allows alignment of the two images used in the registration process and also calculates the required shifts. Shifts calculated using MIM are compared with those submitted by institutions for IGRT credentialing. Reported shifts are considered to be acceptable if differences are less than 3mm. Results: Several tests have been performed on the 2D-2D and 2D-3D registration. The results indicated good agreement between submitted and calculated shifts. A workflow for reviewing these IGRT submissions has been developed and will eventually be used to review IGRT submissions. Conclusion: The IROC Philadelphia RTQA center has developed and tested a new workflow for reviewing DICOM 2D-2D and 2D-3D IGRT credentialing submissions made by different cancer clinical centers, especially proton centers. NRG Center for Innovation in Radiation Oncology (CIRO) and IROC RTQA center continue their collaborative efforts to enhance

WE-AB-BRA-07: Quantitative Evaluation of 2D-2D and 2D-3D Image Guided Radiation Therapy for Clinical Trial Credentialing, NRG Oncology/RTOG

International Nuclear Information System (INIS)

Giaddui, T; Yu, J; Xiao, Y; Jacobs, P; Manfredi, D; Linnemann, N

2015-01-01

Purpose: 2D-2D kV image guided radiation therapy (IGRT) credentialing evaluation for clinical trial qualification was historically qualitative through submitting screen captures of the fusion process. However, as quantitative DICOM 2D-2D and 2D-3D image registration tools are implemented in clinical practice for better precision, especially in centers that treat patients with protons, better IGRT credentialing techniques are needed. The aim of this work is to establish methodologies for quantitatively reviewing IGRT submissions based on DICOM 2D-2D and 2D-3D image registration and to test the methodologies in reviewing 2D-2D and 2D-3D IGRT submissions for RTOG/NRG Oncology clinical trials qualifications. Methods: DICOM 2D-2D and 2D-3D automated and manual image registration have been tested using the Harmony tool in MIM software. 2D kV orthogonal portal images are fused with the reference digital reconstructed radiographs (DRR) in the 2D-2D registration while the 2D portal images are fused with DICOM planning CT image in the 2D-3D registration. The Harmony tool allows alignment of the two images used in the registration process and also calculates the required shifts. Shifts calculated using MIM are compared with those submitted by institutions for IGRT credentialing. Reported shifts are considered to be acceptable if differences are less than 3mm. Results: Several tests have been performed on the 2D-2D and 2D-3D registration. The results indicated good agreement between submitted and calculated shifts. A workflow for reviewing these IGRT submissions has been developed and will eventually be used to review IGRT submissions. Conclusion: The IROC Philadelphia RTQA center has developed and tested a new workflow for reviewing DICOM 2D-2D and 2D-3D IGRT credentialing submissions made by different cancer clinical centers, especially proton centers. NRG Center for Innovation in Radiation Oncology (CIRO) and IROC RTQA center continue their collaborative efforts to enhance

Structure and vibrational frequencies of gaseous europium dibromide

International Nuclear Information System (INIS)

Giricheva, N.I.; Girichev, S.A.; Shlykov, S.A.; Pelipets, O.V.

2000-01-01

Structure of EuBr 2 molecule is studied in the framework of synchronous electron diffraction and mass-spectrometric experiment at the temperature of 1373(20) K. It is found that the molecule has a nonlinear equilibrium configuration, being characterized by the following effective parameters: r g (Eu - Br) = 2.767 A, r g (Br - Br) = 5.11(5) A, l g (Eu - Br) = 0.109(2) A, l g (Br - Br) = 0.388(5) A, valence angle (Br - Eu - Br) = 135.0(3.5) deg. The electron diffraction data permit ascertaining vibration frequencies ν 1 225(10) cm -1 and ν 2 = 40(4) cm -1 [ru

MnO{sub 2} nanorods/3D-rGO composite as high performance anode materials for Li-ion batteries

Energy Technology Data Exchange (ETDEWEB)

Liu, Hongdong; Hu, Zhongli; Su, Yongyao; Ruan, Haibo; Hu, Rong [Research Institute for New Materials Technology, Chongqing University of Arts and Sciences, Chongqing 402160 (China); Zhang, Lei, E-mail: leizhang0215@126.com [College of Life Science, Chongqing Normal University, Chongqing 401331 (China)

2017-01-15

Highlights: • MnO{sub 2} nanorods/3D-rGO composite has been synthesized by a simple in situ hydrothermal methord. • MnO{sub 2} nanorods/3D-rGO composite exhibits high reversible capacity, outstanding rate capacity and excellent cyclic stability. • Building metal oxides/3D-rGO composite is an effective way for improving the electrochemical performance of Li-ion batteries. - Abstract: MnO{sub 2} nanorods/three-dimensional reduced graphene oxide (3D-rGO) composite has been synthesized by a simple in situ hydrothermal methord. The X-ray diffraction (XRD) pattern of the as-prepared composite reveals tetragonal structure of α-MnO{sub 2.} Raman spectroscopic and X-ray photoelectron spectroscopy (XPS) of the samples confirm the coexistence of MnO{sub 2} and graphene. The Brunauer-Emmett-Teller (BET) analysis shows the large surface area of the composite. The electron microscopy images of the as-synthesized products reveals the MnO{sub 2} nanorods are homogeneously grown on 3D-rGO matrix. Electrochemical characterization exhibits the MnO{sub 2} nanorods/3D-rGO composite with large reversible capacity (595 mA h g{sup −1} over 60 cycles at 100 mA g{sup −1}), high coulombic efficiency (above 99%), excellent rate capability and good cyclic stability. The superior electrochemical performance can be attributed to the turf-like nanostructure of composite, high capacity of MnO{sub 2} and superior electrical conductivity of 3D-rGO. It suggests that MnO{sub 2} nanorods/3D-rGO composite will be a promising anode material for Li-ion batteries.

miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL-2: a potential for therapeutic intervention.

Science.gov (United States)

Srivastava, Niloo; Manvati, Siddharth; Srivastava, Archita; Pal, Ranjana; Kalaiarasan, Ponnusamy; Chattopadhyay, Shilpi; Gochhait, Sailesh; Dua, Raina; Bamezai, Rameshwar N K

2011-04-04

New levels of gene regulation with microRNA (miR) and gene copy number alterations (CNAs) have been identified as playing a role in various cancers. We have previously reported that sporadic breast cancer tissues exhibit significant alteration in H2AX gene copy number. However, how CNA affects gene expression and what is the role of miR, miR-24-2, known to regulate H2AX expression, in the background of the change in copy number, are not known. Further, many miRs, including miR-24-2, are implicated as playing a role in cell proliferation and apoptosis, but their specific target genes and the pathways contributing to them remain unexplored. Changes in gene copy number and mRNA/miR expression were estimated using real-time polymerase chain reaction assays in two mammalian cell lines, MCF-7 and HeLa, and in a set of sporadic breast cancer tissues. In silico analysis was performed to find the putative target for miR-24-2. MCF-7 cells were transfected with precursor miR-24-2 oligonucleotides, and the gene expression levels of BRCA1, BRCA2, ATM, MDM2, TP53, CHEK2, CYT-C, BCL-2, H2AFX and P21 were examined using TaqMan gene expression assays. Apoptosis was measured by flow cytometric detection using annexin V dye. A luciferase assay was performed to confirm BCL-2 as a valid cellular target of miR-24-2. It was observed that H2AX gene expression was negatively correlated with miR-24-2 expression and not in accordance with the gene copy number status, both in cell lines and in sporadic breast tumor tissues. Further, the cells overexpressing miR-24-2 were observed to be hypersensitive to DNA damaging drugs, undergoing apoptotic cell death, suggesting the potentiating effect of mir-24-2-mediated apoptotic induction in human cancer cell lines treated with anticancer drugs. BCL-2 was identified as a novel cellular target of miR-24-2. mir-24-2 is capable of inducing apoptosis by modulating different apoptotic pathways and targeting BCL-2, an antiapoptotic gene. The study suggests

R&D Subsidiary Mandates of Western MNEs in China:

DEFF Research Database (Denmark)

Schulzmann, David; Slepniov, Dmitrij

2016-01-01

The number of Western MNCs established R&D centers in China has been rising from the year 2000 starting with under 200 centers to over 1300 centers by the end of 2010 (Stanley, Yang, & Ritacca, 2013). These developments followed increased Foreign Direct Investment (FDI) to China, underpinned...... in the world (Motohashi, 2012). These R&D investments to a large extent are flowing into technological parks with good supporting infrastructure in Beijing, Shanghai, Guangzhou and Shenzhen (Stanley et al., 2013; Walsh, 2007). Aside from the lucrative advantages of offshoring R&D to China, there are numerous...... was primarily focused on development and product adaptation to the local market (Lundin & Serger, 2007), rather than conducting new basic research which could be applied globally across the MNC (Bartlett & Ghoshal, 1998; Govindarajan & Trimble, 2012). Overtime, some R&D subsidiaries evolved and achieved...

On backstops and boomerangs. Environmental R and D under technological uncertainty

International Nuclear Information System (INIS)

Goeschl, Timo; Perino, Grischa

2009-01-01

In areas such as climate change, the recent economic literature has been emphasizing and addressing the pervasive presence of uncertainty. This paper considers a new and salient form of uncertainty, namely uncertainty regarding the environmental characteristics of 'green' innovations. Here, R and D may generate both backstop technologies and technologies that turn out to involve a new pollution problem ('boomerangs'). In the optimum, R and D will therefore typically be undertaken more than once. Extending results from multi-stage optimal control theory, we present a tractable model with a full characterization of the optimal pollution and R and D policies and the role of uncertainty. In this setting, (i) the optimal R and D program is defined by a research trigger condition in which the decision-maker's belief about the probability of finding a backstop enters in an intuitive way; (2) a decreasing probability of finding a backstop leads to the toleration of higher pollution levels, slower R and D, a slower turnover of technologies, and an ambiguous effect on the expected number of innovations; (3) learning about the probability of a backstop is driven by failures only and leads to decreasing research incentives; and (4) small to moderate delays in the resolution of technological uncertainty do not affect the optimal policy. (author)

Domestic R&D and Offshoring

DEFF Research Database (Denmark)

Junge, Martin; Sørensen, Anders

2017-01-01

survey and register data. No evidence is found for a lower probability of own R&D after offshoring takes place compared to before. Moreover, offshoring does not lead to lower R&D intensity in general. However, firms that offshore R&D activity have larger R&D intensity after offshoring has taken place...

SSM: Inference for time series analysis with State Space Models

OpenAIRE

Dureau, Joseph; Ballesteros, Sébastien; Bogich, Tiffany

2013-01-01

The main motivation behind the open source library SSM is to reduce the technical friction that prevents modellers from sharing their work, quickly iterating in crisis situations, and making their work directly usable by public authorities to serve decision-making.

Sundanese ancient manuscripts search engine using probability approach

Science.gov (United States)

Suryani, Mira; Hadi, Setiawan; Paulus, Erick; Nurma Yulita, Intan; Supriatna, Asep K.

2017-10-01

Today, Information and Communication Technology (ICT) has become a regular thing for every aspect of live include cultural and heritage aspect. Sundanese ancient manuscripts as Sundanese heritage are in damage condition and also the information that containing on it. So in order to preserve the information in Sundanese ancient manuscripts and make them easier to search, a search engine has been developed. The search engine must has good computing ability. In order to get the best computation in developed search engine, three types of probabilistic approaches: Bayesian Networks Model, Divergence from Randomness with PL2 distribution, and DFR-PL2F as derivative form DFR-PL2 have been compared in this study. The three probabilistic approaches supported by index of documents and three different weighting methods: term occurrence, term frequency, and TF-IDF. The experiment involved 12 Sundanese ancient manuscripts. From 12 manuscripts there are 474 distinct terms. The developed search engine tested by 50 random queries for three types of query. The experiment results showed that for the single query and multiple query, the best searching performance given by the combination of PL2F approach and TF-IDF weighting method. The performance has been evaluated using average time responds with value about 0.08 second and Mean Average Precision (MAP) about 0.33.

Magnetic moment and magnetocrystalline anisotropy of 3d-ion subsystem in R2T14B

International Nuclear Information System (INIS)

Bartashevich, M.I.; Kudrevatykh, N.V.; Andreev, A.V.; Rejmer, V.A.

1990-01-01

The effect of substituting cobalt for iron on the magnetic moment, magneto-crystalline anisotropy and thermal expansion of R 2 (Fe 1-x Co x ) 14 B single crystals (R=Y, Gd, 0≤x≤0.3) is investigated. The uniaxial magnetic anisotropy constant K 1 for the 3d-subsystem passes through a maximum at T=4.2 K with increasing Co concentration. For T c the temperature dependence of K 1 does not possess a positive slope. The magnetic moment of the 3d-subsystem at 4.2 K does not exhibit the maximum at intermediate concentrations observed for most R(Fe, Co)-intermetallics. An explanation is presented of the changes in the magnetic properties. It is shown that the variation of the interatomic distances on thermal expansion should not affect the magnitude of the anisotropy constant of the 3d- and R-subsystems

Energy Saving Melting and Revert Reduction Technology: Innovative Semi-Solid Metal (SSM) Processing

Energy Technology Data Exchange (ETDEWEB)

Diran Apelian

2012-08-15

Semi-solid metal (SSM) processing has emerged as an attractive method for near-net-shape manufacturing due to the distinct advantages it holds over conventional near-net-shape forming technologies. These advantages include lower cycle time, increased die life, reduced porosity, reduced solidification shrinkage, improved mechanical properties, etc. SSM processing techniques can not only produce the complex dimensional details (e.g. thin-walled sections) associated with conventional high-pressure die castings, but also can produce high integrity castings currently attainable only with squeeze and low-pressure permanent mold casting processes. There are two primary semi-solid processing routes, (a) thixocasting and (b) rheocasting. In the thixocasting route, one starts from a non-dendritic solid precursor material that is specially prepared by a primary aluminum manufacturer, using continuous casting methods. Upon reheating this material into the mushy (a.k.a. "two-phase") zone, a thixotropic slurry is formed, which becomes the feed for the casting operation. In the rheocasting route (a.k.a. "slurry-on-demand" or "SoD"), one starts from the liquid state, and the thixotropic slurry is formed directly from the melt via careful thermal management of the system; the slurry is subsequently fed into the die cavity. Of these two routes, rheocasting is favored in that there is no premium added to the billet cost, and the scrap recycling issues are alleviated. The CRP (Trade Marked) is a process where the molten metal flows through a reactor prior to casting. The role of the reactor is to ensure that copious nucleation takes place and that the nuclei are well distributed throughout the system prior to entering the casting cavity. The CRP (Trade Marked) has been successfully applied in hyper-eutectic Al-Si alloys (i.e., 390 alloy) where two liquids of equal or different compositions and temperatures are mixed in the reactor and creating a SSM slurry. The process has been mostly

Collaborative Product Development in an R&D Environment

Science.gov (United States)

Davis, Jose M.; Keys, L. Ken; Chen, Injazz J.; Peterson, Paul L.

2004-01-01

Research and development (R&D) organizations are being required to be relevant, to be more application-oriented, and to be partners in the strategic management of the business while meeting the same challenges as the rest of the organization, namely: (1) reduced time to market; (2) reduced cost; (3) improved quality; (4) increased reliability; and (5) increased focus on customer needs. Recent advances in computer technology and the Internet have created a new paradigm of collaborative engineering or collaborative product development (CPD), from which new types of relationships among researchers and their partners have emerged. Research into the applicability and benefits of CPD in a low/no production, R&D, and/or government environment is limited. In addition, the supply chain management (SCM) aspects of these relationships have not been studied. This paper presents research conducted at the NASA Glenn Research Center (GRC) investigating the applicability of CPD and SCM in an R&D organization. The study concentrates on the management and implementation of space research activities at GRC. Results indicate that although the organization is engaged in collaborative relationships that incorporate aspects of SCM, a number of areas, such as development of trust and information sharing merit special attention.

What Does It Mean to Repurpose a Test? R&D Connections. Number 9

Science.gov (United States)

Wendler, Cathy; Powers, Donald

2009-01-01

Should individuals use a test for purposes other than those for which it was originally intended? Should they give it to groups of people other than those for whom it was originally designed? This issue of "Educational Testing Service (ETS) R&D Connections" provides ideas for repurposing tests. (Contains 1 footnote.)

Spanish electrical sector and Nuclear R and D

International Nuclear Information System (INIS)

Salve, R.

1994-01-01

This article presents the global situation of the R and D in Nuclear Sector. The author proposes they way to obtain the best results in the R and D area. This way is: 1.- Clear objectives 2.- Integration of R and D into the enterprise plan. 3.- More decision capacity 4.- To plan the long-term benefits

Frame properties of wave packet systes in L^2 (R^d)

DEFF Research Database (Denmark)

Christensen, Ole; Rahimi, Asghar

2008-01-01

Extending work by Hernandez, Labate and Weiss, we present a sufficent condition for a generalized shift-invariant system to be a Bessel sequence or even a frame forL(2)(R-d). In particular, this leads to a sufficient condition for a wave packet system to form a frame. On the other hand, we show...

Association of Novelty Seeking Scores and Striatal Dopamine D2/D3 Receptor Availability of Healthy Volunteers: Single Photon Emission Computed Tomography With 123I-iodobenzamide

Directory of Open Access Journals (Sweden)

Hsiang Yu Huang

2010-10-01

Full Text Available It has been speculated that novelty seeking (NS behavior is related to the dopaminergic system. Fifty-two subjects completed the Tridimensional Personality Questionnaire and underwent single photon emission computed tomography with 123I-iodobenzamide. A marginally positive correlation was noted between NS and striatal dopamine D2/D3 receptor availability (r = 0.25, p =0.07. A positive association was noted between the NS scores and left striatal D2/D3 receptor availability (r= 0.29, p =0.04. The results suggest that a relationship might exist between NS score and dopaminergic activity.

Energy R and D in the Netherlands

Energy Technology Data Exchange (ETDEWEB)

EEM Luiten; JJ Dooley; K Blok

1999-09-07

This report documents trends in R and D and in particular (public) energy R and D in the Netherlands. Besides quantitative information on R and D and energy R and D, the report gives an impression of changes in science and technology policy, energy policy and changes in energy research priorities (both organizational and financial). In the Netherlands, 2.09% of GDP (or $6.7 billion) was invested in R and D activities in 1995. The private sector financed 46% of all R and D in that year. A small but significant fraction (9.3%) of the research performed in the Netherlands is financed by foreign public and private sector entities. Energy R and D has been identified by the national Strategic Foresight Activity as an important area of R and D for government support in the future. This is due in part to the overall decline in public support for energy R and D that occurred from 1985 to 1995. However, recent concern over climate change and energy policy has resulted in increased budgets for energy R and D. Recent policy documents (e.g., the Memorandum on Energy R and D in April 1998) and initiatives (e.g., a recent university energy R and D program; intensification of climate policy, partly in R and D) indicate the growing interest in addressing the issue of climate change partly through energy R and D. The Dutch government believes that the liberalization of the energy market in the Netherlands justifies an active role for the government to guarantee the longer-term transformation to a sustainable energy system. In terms of climate policy, the expanded and more efficient use of natural gas is seen as a suitable transition option towards a sustainable energy system. However, energy efficiency (and in particular energy efficiency in the industrial sector) and the introduction of renewable technologies (solar energy, wind energy and biomass) are generally favored for the long term. Recently, additional funding was allocated for research on industrial &apos

EU R and D on divertor components

International Nuclear Information System (INIS)

Merola, M.; Daenner, W.; Pick, M.

2005-01-01

Since the last SOFT conference held in Helsinki in 2002, substantial progress has been made in the EU R and D on the divertor components. A number of activities have been completed and new ones have been launched. The present paper gives an update of the works carried out by the EU Participating Team in support of the development of the divertor, which is one of the most challenging components of the next-step ITER machine. The following topics are covered: (1) the further development and consolidation of suitable technologies for the production of high heat-flux components, which culminated with the successful manufacturing and testing of a full-scale vertical target prototype; (2) the completion of the post-irradiation testing of divertor mock-ups and samples; (3) the preparation for the hydraulic and assembly tests of a complete set of full-scale divertor components; (4) the on-going R and D on the definition of workable acceptance criteria for the procurement of ITER high heat-flux components; (5) the activities in support of the divertor design

Energy R and D in Germany; TOPICAL

International Nuclear Information System (INIS)

PJ Runci

1999-01-01

Germany's total national (i.e., combined public and private sector) funding for R and D stood at$42 billion in 1997. The private sector accounted for nearly 62% ($24 billion) of the total, while the public sector accounted for approximately 38%. Since the late 1970s, when the public and private sectors each funded roughly half of Germany's R and D, the private sector has steadily assumed a larger and larger role as the dominant supporter of R and D activity, while overall government funding has remained essentially flat for much of the past two decades. In addition to declining relative to private R and D expenditures, public R and D expenditures in Germany declined by 4% in real terms between 1991 and 1997, to approximately$15 billion. The reduction in R and D investments in the public sector can be attributed in large part to the financial challenges associated with German reunification and related shifts in social priorities including efforts to address high unemployment and to rebuild basic infrastructure in the eastern states. R and D expenditures have also declined as a percentage of the total public budget, from a peak of 3.4% in 1985 to 2.7% in 1996. Energy R and D has been the hardest hit of all major socioeconomic areas of R and D expenditure funded by the German government. Between 1981 and 1997, public energy R and D fell from approximately$1.6 billion to$400 million--a 75% real decline. The$850 million reduction in Germany's fission R and D budget (which constituted two-thirds of government R and D investment in 1985) explains some 90% of the funding decline. Negative public perceptions regarding the safety and environmental impacts of nuclear energy have reduced nuclear power's viability as a long-term energy option for Germany. Discussions of a complete nuclear phaseout are now under way. At the same time, the German government has slashed its investments in fossil energy R and D by more than 90%. While energy efficiency and renewable energy

R&D INVESTMENTS AND SPILLOVERS UNDER ENDOGENOUS ABSORPTIVE CAPACITY: COMPETITIVE R&D CANNOT TAKE FULL-ADVANTAGE OF COMPLEMENTARITY IN ABSORPTIVE CAPACITY WHILE COOPERATIVE R&D CAN

Directory of Open Access Journals (Sweden)

Mário A.P.M. Da Silva

2018-03-01

Full Text Available We show that the setting up of general conditions on complementarity in absorptive capacity gives rise to different, if not opposite Nash equilibrium outcomes to those found when absorptive capacity is assumed to be determined only by the similarity of R&D orientations. Firms that cooperate in R&D can take full-advantage of complementarity in R&D by adopting firm-specific R&D paths, which appears to contradict findings and predictions of existing theoretical literature on R&D and spillovers. Oddly, firms competing in R&D cannot gain the most from the potential of complementarity in knowledge by not choosing firm-specific R&D approaches in equilibrium under even milder conditions, which is contrary to another prediction of existing related models.

Low R&D Efficiency in Large Pharmaceutical Companies

DEFF Research Database (Denmark)

Madsen, Erik Strøjer; Wu, Yanqing

2016-01-01

Large pharmaceutical companies will face serious challenges in the future when several of their blockbuster drugs run out of patents, and meanwhile a growing political pressure to stop the fast increase in health care expenditures has merged. The recent wave of mergers and acquisitions (M&A) within...... the industry can be seen as an effective means to reduce costs and compensate for the reduced earnings from patented drugs. The paper examines the main development in expenditure on research and development (R&D) and number of patents in the industry with a focus on the role of company size. The analysis...... builds on a data set containing information of both patents and R&D expenditure from the world’s top 90 largest pharmaceutical companies, as well as their account data from 2002 to 2013. The empirical part estimates the firm size effect on R&D efficiency and the amount of investment allocated to R...

DMSP SSM/I Daily and Monthly Polar Gridded Bootstrap Sea Ice Concentrations

Data.gov (United States)

National Aeronautics and Space Administration — DMSP SSM/I Daily and Monthly Polar Gridded Bootstrap Sea Ice Concentrations in polar stereographic projection currently include Defense Meteorological Satellite...

Selective and interactive effects of D2 receptor antagonism and positive allosteric mGluR4 modulation on waiting impulsivity.

Science.gov (United States)

Isherwood, Sarah N; Robbins, Trevor W; Nicholson, Janet R; Dalley, Jeffrey W; Pekcec, Anton

2017-09-01

Metabotropic glutamate receptor 4 (mGluR4) and dopamine D 2 receptors are specifically expressed within the indirect pathway neurons of the striato-pallidal-subthalamic pathway. This unique expression profile suggests that mGluR4 and D 2 receptors may play a cooperative role in the regulation and inhibitory control of behaviour. We investigated this possibility by testing the effects of a functionally-characterised positive allosteric mGluR4 modulator, 4-((E)-styryl)-pyrimidin-2-ylamine (Cpd11), both alone and in combination with the D 2 receptor antagonist eticlopride, on two distinct forms of impulsivity. Rats were trained on the five-choice serial reaction time task (5-CSRTT) of sustained visual attention and segregated according to low, mid, and high levels of motor impulsivity (LI, MI and HI, respectively), with unscreened rats used as an additional control group. A separate group of rats was trained on a delay discounting task (DDT) to assess choice impulsivity. Systemic administration of Cpd11 dose-dependently increased motor impulsivity and impaired attentional accuracy on the 5-CSRTT in all groups tested. Eticlopride selectively attenuated the increase in impulsivity induced by Cpd11, but not the accompanying attentional impairment, at doses that had no significant effect on behavioural performance when administered alone. Cpd11 also decreased choice impulsivity on the DDT (i.e. increased preference for the large, delayed reward) and decreased locomotor activity. These findings demonstrate that mGluR4s, in conjunction with D 2 receptors, affect motor- and choice-based measures of impulsivity, and therefore may be novel targets to modulate impulsive behaviour associated with a number of neuropsychiatric syndromes. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Aging characteristics of 0.7Pb(Mg{sub 1/3}Nb{sub 2/3})O{sub 3}-0.3PbTiO{sub 3} single crystals with different crystal orientations

Energy Technology Data Exchange (ETDEWEB)

Liu, Xing [Changzhou University, School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou (China); Chinese Academy of Sciences, Key Laboratory of Inorganic Function Material and Device, Shanghai (China); Wu, Dun; Fang, Bijun [Changzhou University, School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou (China); Ding, Jianning [Changzhou University, School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou (China); Jiangsu University, School of Material Science and Engineering, Zhenjiang (China); Li, Xiaobing; Zhao, Xiangyong; Luo, Haosu [Chinese Academy of Sciences, Key Laboratory of Inorganic Function Material and Device, Shanghai (China); Ko, Jae-Hyeon [Hallym University, Department of Physics, Chuncheon (Korea, Republic of); Ahn, Chang Won [University of Ulsan, Department of Physics and EHSRC, Ulsan (Korea, Republic of)

2015-06-15

In this work, the time and temperature dependence of the piezoelectric and ferroelectric properties of the 0.7Pb(Mg{sub 1/3}Nb{sub 2/3})O{sub 3}-0.3PbTiO{sub 3} (0.7PMN-0.3PT) single crystals were investigated in order to search for an effective method to improve their properties further. The piezoelectric properties of the [001]-, [110]- and [111]-oriented 0.7PMN-0.3PT single crystals exhibit excellent time stability during the 2-month room-temperature aging process. The re-poling process leads to the improvement of piezoelectric constant d{sub 33} for the [001]-, [110]- and [111]-oriented 0.7PMN-0.3PT single crystals, while the values of electromechanical coupling coefficient k{sub t} change little. During the thermal aging, the values of the measured d{sub 33}, calculated converse piezoelectric constant d{sub 33}{sup *}, maximum strain S{sub max}% and longitudinal electrostrictive coefficient Q of the [001]-, [110]- and [111]-oriented crystal plates increase gradually before the ferroelectric phase transition temperatures (T{sub FPT}, T{sub R-M}, T{sub R-O} and T{sub R-T}) and then decline continuously. The increase in these values before the T{sub FPT} is a result of the phase instability. In general, the [001]- and [110]-oriented 0.7PMN-0.3PT single crystals exhibit large piezoelectricity, excellent time stability and relatively high thermal stability between 20 and 80 C, which is favorable to the piezoelectric applications. (orig.)

R ampersand D activities at DOE applicable to mixed waste

International Nuclear Information System (INIS)

Erickson, M.D.; Devgun, J.S.; Brown, J.J.; Beskid, N.J.

1991-01-01

The Department of Energy (DOE) has established the Office of Environmental Restoration and Waste Management. Within the new organization, the Office of Technology Development (OTD) is responsible for research, development, demonstration, testing and evaluation (RDDT ampersand E) activities aimed at meeting DOE cleanup goals, while minimizing cost and risk. Because of US governmental activities dating back to the Manhattan project, mixed radioactive and hazardous waste is an area of particular concern to DOE. The OTD is responsible for a number of R ampersand D activities aimed at improving capabilities to characterize, control, and properly dispose of mixed waste. These activities and their progress to date will be reviewed. In addition, needs for additional R ampersand D on managing mixed waste will be presented. 5 refs., 2 tabs

The determination of the Dirac density matrix of the d-dimensional harmonic oscillator for an arbitrary number of closed shells

International Nuclear Information System (INIS)

Howard, I.A.; March, N.H.; Nieto, L.M.

2002-01-01

In 1959, March and Young (Nucl. Phys. 12 237) rewrote the equation of motion for the Dirac density matrix γ(x, x 0 ) in terms of sum and difference variables. Here, γ(r-bar, r-bar 0 ) for the d-dimensional isotropic harmonic oscillator for an arbitrary number of closed shells is shown to satisfy, using the variables vertical bar r-bar + r-bar 0 vertical bar/2 and vertical bar r-bar - r-bar 0 vertical bar/2, a generalized partial differential equation embracing the March-Young equation for d=1. As applications, we take in turn the cases d=1, 2, 3 and 4, and obtain both the density matrix γ (r-bar, r-bar 0 ) and the diagonal density ρ(r)=γ(r-bar, r-bar 0 ) vertical bar r-bar 0 =r-bar, this diagonal element already being known to satisfy a third-order linear homogeneous differential equation for d=1 through 3. Some comments are finally made on the d-dimensional kinetic energy density, which is important for first-principles density functional theory in allowing one to bypass one-particle Schroedinger equations (the so-called Slater-Kohn-Sham equations). (author)

Visegrad Four countries: evaluation in R&D sectors of performance

Directory of Open Access Journals (Sweden)

Nina Bočková

2013-01-01

Full Text Available Competitiveness is currently being studied by many economic analyses. Generalization of the countries’ competitiveness definition as a measure of understanding of the performance evaluation economies is important. Visegrad Four countries: Hungary, the Czech Republic, Slovakia and Poland were admitted to the European Union in May 2004. EU Member States must respect the common EU objectives. The European Union, as expressed in the strategy Europe 2020, is obliged to increase competitiveness, innovation, by introduction of modern technology and especially the growth R&D investment. Limited data to evaluate R&D expenditure: inconsistencies in the R&D support, the absence of data concerning the other means of financing in the sector BERD, limitations of statistical data on the number of innovations only to firms with R&D activities. The aim of this paper is to evaluate the development of R&D expenditures by sector of funding in the Visegrad Four countries in comparison with the values of the EU-27 and countries of Visegrad Four together.

40 CFR 22.2 - Use of number and gender.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Use of number and gender. 22.2 Section... PERMITS General § 22.2 Use of number and gender. As used in these Consolidated Rules of Practice, words in the singular also include the plural and words in the masculine gender also include the feminine, and...

Morris water maze learning in Long-Evans rats is differentially affected by blockade of D1-like and D2-like dopamine receptors

Czech Academy of Sciences Publication Activity Database

Stuchlík, Aleš; Řeháková, Lenka; Telenský, Petr; Valeš, Karel

2007-01-01

Roč. 422, č. 3 (2007), s. 169-174 ISSN 0304-3940 R&D Projects: GA MŠk(CZ) 1M0517; GA MŠk(CZ) LC554; GA MZd NR9178; GA ČR GA309/07/0341; GA ČR(CZ) GD206/05/H012; GA ČR(CZ) GA309/06/1231 Institutional research plan: CEZ:AV0Z50110509 Keywords : memory * dopamine * cognition Subject RIV: FH - Neurology Impact factor: 2.085, year: 2007

A multisensor approach to sea ice classification for the validation of DMSP-SSM/I passive microwave derived sea ice products

Science.gov (United States)

Steffen, K.; Schweiger, A. J.

1990-01-01

The validation of sea ice products derived from the Special Sensor Microwave Imager (SSM/I) on board a DMSP platform is examined using data from the Landsat MSS and NOAA-AVHRR sensors. Image processing techniques for retrieving ice concentrations from each type of imagery are developed and results are intercompared to determine the ice parameter retrieval accuracy of the SSM/I NASA-Team algorithm. For case studies in the Beaufort Sea and East Greenland Sea, average retrieval errors of the SSM/I algorithm are between 1.7 percent for spring conditions and 4.3 percent during freeze up in comparison with Landsat derived ice concentrations. For a case study in the East Greenland Sea, SSM/I derived ice concentration in comparison with AVHRR imagery display a mean error of 9.6 percent.

A case study of R&D internationalisation in Brazil

Directory of Open Access Journals (Sweden)

Dusan Schreiber

2015-05-01

Full Text Available The decision-making process that results in installing R&D activities outside of an organisation (whether nationally or abroad involves a number of variables that deserve a more detailed analysis of their specificities. This need stems from the importance that R&D activities have taken in recent years in the organisational universe, due to the potential constitution of competitive advantage. However, following the logic of rationality contained in the theory of transaction costs demonstrated by the dilemma "Make or Buy?", R&D activities were also included in the process of evaluating the feasibility and relevance of carrying out activities internally or externally. In many cases outsourcing has occurred across national borders. This article was created with the aim of analysing the specifics of the decision-making process of three multinationals that have outsourced their R&D activities to Brazil. It is hoped that a contribution to the debate on the advantages and benefits of outsourcing these activities will be made.

The CM SAF SSM/I-based total column water vapour climate data record: methods and evaluation against re-analyses and satellite

Directory of Open Access Journals (Sweden)

M. Schröder

2013-03-01

Full Text Available The European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT Satellite Application Facility on Climate Monitoring (CM SAF aims at the provision and sound validation of well documented Climate Data Records (CDRs in sustained and operational environments. In this study, a total column water vapour path (WVPA climatology from CM SAF is presented and inter-compared to water vapour data records from various data sources. Based on homogenised brightness temperatures from the Special Sensor Microwave Imager (SSM/I, a climatology of WVPA has been generated within the Hamburg Ocean–Atmosphere Fluxes and Parameters from Satellite (HOAPS framework. Within a research and operation transition activity the HOAPS data and operation capabilities have been successfully transferred to the CM SAF where the complete HOAPS data and processing schemes are hosted in an operational environment. An objective analysis for interpolation, namely kriging, has been applied to the swath-based WVPA retrievals from the HOAPS data set. The resulting climatology consists of daily and monthly mean fields of WVPA over the global ice-free ocean. The temporal coverage ranges from July 1987 to August 2006. After a comparison to the precursor product the CM SAF SSM/I-based climatology has been comprehensively compared to different types of meteorological analyses from the European Centre for Medium-Range Weather Forecasts (ECMWF-ERA40, ERA INTERIM and operational analyses and from the Japan Meteorological Agency (JMA–JRA. This inter-comparison shows an overall good agreement between the climatology and the analyses, with daily absolute biases generally smaller than 2 kg m−2. The absolute value of the bias to JRA and ERA INTERIM is typically smaller than 0.5 kg m−2. For the period 1991–2006, the root mean square error (RMSE for both reanalyses is approximately 2 kg m−2. As SSM/I WVPA and radiances are assimilated into JMA and all ECMWF analyses and

JESS-D-16-00542 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00542 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00067 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00067 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00589 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00589 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00450 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00450 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00284 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00284 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00578 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00578 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00482 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00482 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00418 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00418 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00127R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00127R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00307 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00307 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00302 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00302 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00429 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00429 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00330 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00330 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00409 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00409 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-15-00464R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-15-00464R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00287 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00287 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00197 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00197 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00189 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00189 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00274 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00274 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00392 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00392 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00575 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00575 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00024 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00024 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00523 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00523 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00354R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00354R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00043 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00043 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00107 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00107 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00032 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00032 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00351 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00351 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00222 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00222 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00044 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00044 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00263 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00263 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00005R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00005R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00567 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00567 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Cultural differences and process adaptation in international R&D project management

DEFF Research Database (Denmark)

Li, Xing; Li, J. Z.

2009-01-01

In the era of globalization, Western companies have started to explore China as a source of technology. Yet, Western R&D project management processes in China are frequently facing many problems. Some of the problems can be conceptualized by analyzing a number of known cultural contrasts between ...... project success. At the same time, lessons and recommendations on the adaptability to Chinese style business and management interactions will be drawn from the case study for international companies that locate R&D projects in China.......In the era of globalization, Western companies have started to explore China as a source of technology. Yet, Western R&D project management processes in China are frequently facing many problems. Some of the problems can be conceptualized by analyzing a number of known cultural contrasts between...

Evolution of rDNA in Nicotiana allopolyploids: A potential link between rDNa homogenization and epigenetics

Czech Academy of Sciences Publication Activity Database

Kovařík, Aleš; Nešpor Dadejová, Martina; Lim, Y.K.; Chase, M.W.; Clarkson, J.J.; Knapp, S.; Leitch, A.R.

2008-01-01

Roč. 101, č. 6 (2008), s. 815-823 ISSN 0305-7364 R&D Projects: GA ČR(CZ) GA521/07/0116 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : rDNA * allopolyploidy * evolution-Nicotiana Subject RIV: BO - Biophysics Impact factor: 2.755, year: 2008

User interface design principles for the SSM/PMAD automated power system

International Nuclear Information System (INIS)

Jakstas, L.M.; Myers, C.J.

1991-01-01

Computer-human interfaces are an integral part of developing software for spacecraft power systems. A well designed and efficient user interface enables an engineer to effectively operate the system, while it concurrently prevents the user from entering data which is beyond boundary conditions or performing operations which are out of context. A user interface should also be designed to ensure that the engineer easily obtains all useful and critical data for operating the system and is aware of all faults and states in the system. Martin Marietta, under contract to NASA George C. Marshall Space Flight Center, has developed a user interface for the Space Station Module Power Management and Distribution (SSM/PMAD) automated power system testbed which provides human access to the functionality of the power system, as well as exemplifying current techniques in user interface design. The testbed user interface was designed to enable an engineer to operate the system easily without having significant knowledge of computer systems, as well as provide an environment in which the engineer can monitor and interact with the SSM/PMAD system hardware. The design of the interface supports a global view of the most important data form the various hardware and software components, as well as enabling the user to obtain additional or more detailed data when needed. The components and representations of the SSM/PMAD testbed user interface are examined in this paper. An engineer's interactions with the system are also described

Nuclear Decommissioning R and D: a successful history that goes on. Evolution of R and D for nuclear decommissioning

International Nuclear Information System (INIS)

Laraia, Michele; )

2017-01-01

Research and Development (R and D) in Nuclear Decommissioning date back to the 1980's and 1990's. At that time, decommissioning was a relatively new, sporadic activity; technologies were mostly imported from the non-nuclear field and adapted to nuclear uses (a trend that continues to this day and should not be looked down). R and D were first applied to a laboratory scale, and later on expanded to prototype and pilot installations. The European Commission launched a series of multi-year R and D programmes, ultimately covering the full-scale decommissioning of nuclear power plants and other large installations. Certain installations (especially the BR-3 reactor at Mol, Belgium), were used to test and compare different technologies and assign a ranking based on various factors. In parallel, the US Department of Energy was active in a number of R and D activities, culminating in a number of topical publications until around the year 2000 and the explosive growth of the decommissioning market. In Japan in early 1990's the decommissioning of the Japan Power Demonstration Reactor (JPDR) was used to test almost all dismantling techniques being available at that time: the spin-offs of JPDR work were still flowing into the nuclear community until recently. It has to be also highlighted that the Chernobyl accident boosted a spate of decommissioning R and D aimed at solving practical problems in the aftermath of that severe accident. Although R and D in this field peaked around the year 2000, R and D efforts have continued to this day. While decommissioning is not 'rocket science' and it can be safely stated that this industry has reached maturity, there are areas (e.g. management of secondary waste, access, characterization and dismantling in 'difficult' environments) that require further efforts to optimize processes and reduce the still high costs. The IAEA has contributed to these advances in various ways. For example, some 50 topical reports on the decommissioning of

ITER technology R and D during the EDA

International Nuclear Information System (INIS)

Mizoguchi, T.

2001-01-01

A short overview of the ITER technology R and D achievements is presented. It includes R and D programme in the area of superconducting magnets, L-1 central solenoid model coil, L-2 toroidal field model coil, L-3 vacuum vessel sector, L-4 blanket module, L-5 divertor cassette, L-6 blanket and L-7 divertor remote handling systems. In addition to the seven large R and D projects, development of components for fuelling, pumping, tritium processing, heating/current drive, power supplies and plasma diagnostics, as well as safety-related R and D have significantly progressed

planSOEC. R and D and commercialization roadmap for SOEC electrolysis. R and D of SOEC stacks with improved durability. Project report

Energy Technology Data Exchange (ETDEWEB)

Richter, A.; Friis Pedersen, C.; Nielsen, Jens Ulrik [Topsoe Fuel Cells A/S, Kgs. Lyngby (Denmark); Mogensen, M.; Hoejgaard Jensen, S.; Ming Chen [Technical Univ. of Denmark. Fuel Cells and Solid State Chemistry Div., DTU Risoe Campus, Roskilde (Denmark); Sloth, M. [H2 Logic A/S, Herning (Denmark)

2011-05-15

The project has been divided into two parts: PART 1: Formulation of a R and D and commercialization roadmap for SOEC electrolysis. PART 2: Conducting R and D of SOEC stacks with improved durability. The purpose of Part 1 has been to develop a R and D and commercialisation roadmap for hydrogen and CO production plants based on the solid oxide electrolysis cell (SOEC) technology. SOEC technology is still on an early R and D stage but years of extensive R and D within SOFC technology provides a strong platform for an accelerated commercialisation. However, in order to guide the future SOEC R and D activities towards reaching commercial market requirements a detailed roadmap is necessary. An overall strategy for R and D of various electrolysis technologies in Denmark already exists{sup 2}, formulated in the Hydrogen Production working group in the Danish Hydrogen and Fuel Cell Partnership. The SOEC roadmap developed as part of the planSOEC project supplements the overall strategy, by conducting an updated analysis of state-of-the-art. Also planSOEC provides a detailed analysis of requirements for different market applications for SOEC, which enables formulation of precise and detailed R and D targets. The objectives of Part 2 in this project were multiple: 1) To investigate durability of solid oxide cells (SOCs) and stack components under industrially relevant (''harsh'') electrolysis operating conditions; 2) to investigate performance of standard TOFC (Topsoe Fuel Cell A/S) SOC stacks (based on state-of-the-art solid oxide cells) under mild electrolysis operating conditions ({<=}0.75 A/cm{sup 2}); 3) to further develop SOEC stack computer models available at Riso DTU and TOFC. Accordingly four lines of work were carried out in the here reported project: 1) Investigation of corrosion resistance of interconnect alloys. 2) Cell and stack element testing. 3) SOEC stack testing. 4) SOEC stack modeling. (LN)

40 CFR 209.2 - Use of number and gender.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Use of number and gender. 209.2... gender. In these rules of practice, words in the singular number apply to the plural and words in the masculine gender apply to the feminine and vice versa. ...

The Conserved Arginine Cluster in the Insert of the Third Cytoplasmic Loop of the Long Form of the D2 Dopamine Receptor (D2L-R Acts as an Intracellular Retention Signal

Directory of Open Access Journals (Sweden)

Valentina Kubale

2016-07-01

Full Text Available This study examined whether the conserved arginine cluster present within the 29-amino acid insert of the long form of the D2 dopamine receptor (D2L-R confers its predominant intracellular localization. We hypothesized that the conserved arginine cluster (RRR located within the insert could act as an RXR-type endoplasmic reticulum (ER retention signal. Arginine residues (R within the cluster at positions 267, 268, and 269 were charge-reserved to glutamic acids (E, either individually or in clusters, thus generating single, double, and triple D2L-R mutants. Through analyses of cellular localization by confocal microscopy and enzyme-linked immunosorbent assay (ELISA, radioligand binding assay, bioluminescence resonance energy transfer (BRET2 β-arrestin 2 (βarr2 recruitment assay, and cAMP signaling, it was revealed that charge reversal of the R residues at all three positions within the motif impaired their colocalization with ER marker calnexin and led to significantly improved cell surface expression. Additionally, these data demonstrate that an R to glutamic acid (E substitution at position 2 within the RXR motif is not functionally permissible. Furthermore, all generated D2L-R mutants preserved their functional integrity regarding ligand binding, agonist-induced βarr2 recruitment and Gαi-mediated signaling. In summary, our results show that the conserved arginine cluster within the 29-amino acid insert of third cytoplasmic loop (IC3 of the D2L-R appears to be the ER retention signal.

Near-Real-Time DMSP SSM/I-SSMIS Daily Polar Gridded Brightness Temperatures

Data.gov (United States)

National Aeronautics and Space Administration — The Near-Real-Time DMSP SSM/I-SSMIS Daily Polar Gridded Brightness Temperature product provides near-real-time brightness temperatures for both the Northern and...

2D/3D registration using a rotation-invariant cost function based on Zernike moments

Science.gov (United States)

Birkfellner, Wolfgang; Yang, Xinhui; Burgstaller, Wolfgang; Baumann, Bernard; Jacob, Augustinus L.; Niederer, Peter F.; Regazzoni, Pietro; Messmer, Peter

2004-05-01

We present a novel in-plane rotation invariant cost function for 2D/3D registration utilizing projection-invariant transformation properties and the decomposition of the X-ray nad the DRR under comparision into orhogonal Zernike moments. As a result, only five dof have to be optimized, and the number of iteration necessary for registration can be significantly reduced. Results in a phantom study show that an accuracy of approximately 0.7° and 2 mm can be achieved using this method. We conclude that reduction of coupled dof and usage of linear independent coefficients for cost function evaluation provide intersting new perspectives for the field of 2D/3D registration.

Governance Models of R&D Offshoring: : Innovatoin Performance and Absorptive Capacity

NARCIS (Netherlands)

Steinberg, Philip; Procher, Vivien D.

2015-01-01

The globalization of business functions has led to an increase in offshoring of R&D. Firms’ offshoring models of R&D include captive offshoring (foreign R&D spending to affiliates) and offshore outsourcing (foreign R&D spending to external partners). For 2,421 R&D-active German enterprises we

Determinants of Firm R&D

DEFF Research Database (Denmark)

Tingvall, Patrick Gustavsson; Poldahl, Andreas

2012-01-01

Research and Development (R&D) is a key component behind technological development and economic growth; therefore, understanding the drivers of R&D is crucial. An interesting question is the role of technology spillovers, transferred by trade, and their impact on firm R&D. Here we analyze not only...

Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation.

Directory of Open Access Journals (Sweden)

Ralf C Kling

Full Text Available Residue Arg3.50 belongs to the highly conserved DRY-motif of class A GPCRs, which is located at the bottom of TM3. On the one hand, Arg3.50 has been reported to help stabilize the inactive state of GPCRs, but on the other hand has also been shown to be crucial for stabilizing active receptor conformations and mediating receptor-G protein coupling. The combined results of these studies suggest that the exact function of Arg3.50 is likely to be receptor-dependent and must be characterized independently for every GPCR. Consequently, we now present comparative molecular-dynamics simulations that use our recently described inactive-state and Gα-bound active-state homology models of the dopamine D2 receptor (D2R, which are either bound to dopamine or ligand-free, performed to identify the function of Arg1323.50 in D2R. Our results are consistent with a dynamic model of D2R activation in which Arg1323.50 adopts a dual role, both by stabilizing the inactive-state receptor conformation and enhancing dopamine-dependent D2R-G protein coupling.

Manuscript Transcription by Crowdsourcing: Transcribe Bentham

Directory of Open Access Journals (Sweden)

Martin Moyle

2011-02-01

Full Text Available Transcribe Bentham is testing the feasibility of outsourcing the work of manuscript transcription to members of the public. UCL Library Services holds 60,000 folios of manuscripts of the philosopher and jurist Jeremy Bentham (1748–1832. Transcribe Bentham will digitise 12,500 Bentham folios, and, through a wiki-based interface, allow volunteer transcribers to take temporary ownership of manuscript images and to create TEI-encoded transcription text for final approval by UCL experts. Approved transcripts will be stored and preserved, with the manuscript images, in UCL’s public Digital Collections repository. The project makes innovative use of traditional library material. It will stimulate public engagement with UCL’s scholarly archive collections and the challenges of palaeography and manuscript transcription; it will raise the profile of the work and thought of Jeremy Bentham; and it will create new digital resources for future use by professional researchers. Towards the end of the project, the transcription tool will be made available to other projects and services. This paper is based on a presentation given by the lead author at LIBER’s 39th Annual General Conference in Aarhus, Denmark, 2010.

Manuscripts

Directory of Open Access Journals (Sweden)

François Delsarte

2012-11-01

Full Text Available In these excerpts from a manuscript from the François Delsarte archive, the French author offers us passages from his notebooks, with considerations on the techniques used by singers, especially on degrees and expression. It presents the foundations of his work and offers advices to students. The text explains Delsarte’s viewpoint on inspiration and its role in artistic work. It discusses aspects related to his form of pedagogy in the form of dialogue.

An R&D Management Framework for Eco-Technology

OpenAIRE

Hideki Kobayashi; Masahiro Kato; Yukishige Maezawa; Kenji Sano

2011-01-01

Although research and development (R&D) affects new value-added creation, including that related to environmental aspects, there is little literature dealing with the integration of R&D management and eco-value. Here, eco-value of technology is defined as the advantage of environmental competitiveness in the market. This paper proposes a framework of R&D management of eco-technology (RDMOET), consisting of: (1) future research for sustainability; (2) making an original eco-theme p...

Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone

DEFF Research Database (Denmark)

Coller, J K; Joergensen, C; Foster, D J R

2007-01-01

OBJECTIVE: To investigate the influence of CYP2D6 genotype on the oral clearance of (R)-, (S)- and rac-methadone. METHODS: In this retrospective study, CYP2D6 genotypes were identified in 56 methadone maintained subjects. Plasma concentrations of (R)-, (S)- and rac-methadone were determined by st...

Benefits From R and D For D and D Projects Preparation

International Nuclear Information System (INIS)

Georges, Christine; Boucher, Lionel; Charton, Frederic; Soulabaille, Yves

2016-01-01

CEA (French Alternative Energies and Atomic Energy Commission) is both the operator of important nuclear facilities all over the nuclear cycle, in charge of major new built or Decommissioning and Dismantling (D and D) projects and a R and D group with dynamic policy of technology transfer. The position of CEA in D and D is unique because of the number and the wide diversity of facilities under decommissioning, with some high level of contamination. Innovative solutions are being developed in 6 main axes to protect the operators, to minimize the overall costs and the volumes of waste, especially used when preparing D and D operations: Investigations in the facilities, Radiological measurement of waste, Technologies for hostile environment, Decontamination of soils and structures, Waste treatment and conditioning and Methods and Information Technology (IT) Tools for project and waste management. The last developments are shown and examples of industrial applications given. CEA is willing to share actions in partnership with other operators or with industrials dealing with the same problems to solve. (authors)

Modeling and protein engineering studies of active and inactive states of human dopamine D2 receptor (D2R) and investigation of drug/receptor interactions.

Science.gov (United States)

Salmas, Ramin Ekhteiari; Yurtsever, Mine; Stein, Matthias; Durdagi, Serdar

2015-05-01

Homology model structures of the dopamine D2 receptor (D2R) were generated starting from the active and inactive states of β2-adrenergic crystal structure templates. To the best of our knowledge, the active conformation of D2R was modeled for the first time in this study. The homology models are built and refined using MODELLER and ROSETTA programs. Top-ranked models have been validated with ligand docking simulations and in silico Alanine-scanning mutagenesis studies. The derived extra-cellular loop region of the protein models is directed toward the binding site cavity which is often involved in ligand binding. The binding sites of protein models were refined using induced fit docking to enable the side-chain refinement during ligand docking simulations. The derived models were then tested using molecular modeling techniques on several marketed drugs for schizophrenia. Alanine-scanning mutagenesis and molecular docking studies gave similar results for marketed drugs tested. We believe that these new D2 receptor models will be very useful for a better understanding of the mechanisms of action of drugs to be targeted to the binding sites of D2Rs and they will contribute significantly to drug design studies involving G-protein-coupled receptors in the future.

Remediation technology needs and applied R ampersand D initiatives

International Nuclear Information System (INIS)

Lien, S.C.T.; Levine, R.S.; Webster, S.L.

1991-01-01

The US Department of Energy (DOE) recently consolidated its environmental restoration and waste management activities. Within that new organization, DOE has committed to support Research, Development, Demonstration, Testing and, Evaluation (RDDT ampersand E) activities with the following objectives: rapidly advance beyond currently available technologies; provide solutions to key technical issues that will improve effectiveness, efficiency, and safety; and enhance DOE's ability to meet its 30-year compliance and cleanup goals. Four general categories have been identified where R ampersand D (and DT ampersand E) efforts need to be focused. These include: waste minimization technologies, site characterization and assessment methods, waste treatment technologies, and remediation technologies with emphasis on in-situ methods. The DOE has already supported a number of R ampersand D activities in these areas and plans to continue that support in the future. For technology development, the DOE is committed to forming cooperative partnerships and eliciting broad participation from qualified organizations who can contribute to RDDT ampersand E activities. The new technologies resulting from these R ampersand D initiatives will enhance DOE's ability to meet its 30-year cleanup goal, reduce environmental risk, and provide significant cost savings over existing technologies. Even modest investments in these emerging technologies now can be expected to generate a high rate of return. 3 refs., 2 tabs

Concerted evolution of rDNA in recently formed Tragopogon allotetraploids is typically associated with an inverse correlation between gene copy number and expression

Czech Academy of Sciences Publication Activity Database

Matyášek, Roman; Tate, J. A.; Lim, Y.K.; Šrubařová, Hana; Koh, J.; Leitch, A.R.; Soltis, D.E.; Soltis, P.S.; Kovařík, Aleš

2007-01-01

Roč. 176, č. 4 (2007), s. 2509-2519 ISSN 0016-6731 R&D Projects: GA ČR(CZ) GA204/05/0687; GA ČR(CZ) GA521/07/0116; GA MŠk(CZ) LC06004 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : rDNA silencing * nucleolar dominance * allopolyploidy Subject RIV: BO - Biophysics Impact factor: 4.001, year: 2007

40 CFR 305.2 - Use of number and gender.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Use of number and gender. 305.2... Use of number and gender. As used in this part, words in the singular also include the plural and words in the masculine gender also include the feminine, as the case may require. ...

Exploratory results on the importance of R&D knowledge domains in businesses with different strategies

NARCIS (Netherlands)

Langerak, Fred; Nijssen, Ed; Frambach, Ruud; Gupta, Ashok

A number of studies hare described the consequences of the changing patterns in the business environment for R&D departments. Fewer studies have addressed the specific implications of the changing business environment for the agenda of R&D managers. Gupta and Wilemon (1996) have provided R&D

Review and evaluation of SKB's account of RDandD Programme 2010

International Nuclear Information System (INIS)

2011-03-01

SSM has reviewed and evaluated the RDandD Programme 2010 for planned research and development, reported research results, alternative handling and storage methods, and the actions intended to be taken (Paragraph 26 Nuclear Regulation). This report describes the results of the examination and evaluation. The RDandD programme 2010 has been circulated for national consultation by SSM to approximately 70 organisations

Lusztig symmetries and Poincare-Birkhoff-Witt basis for wU{sub r,s}{sup d}(osp(1|2n))

Energy Technology Data Exchange (ETDEWEB)

Liu, Junli [Mathematics and Information College, Langfang Teachers' College, Langfang 065000 (China); College of Applied Sciences, Beijing University of Technology, Beijing 100124 (China); Yang, Shilin [College of Applied Sciences, Beijing University of Technology, Beijing 100124 (China)

2013-12-15

We investigate a new kind of two-parameter weak quantized superalgebra wU{sub r,s}{sup d}(osp(1|2n)), which is a weak Hopf superalgebra. It has a homomorphic image which is isomorphic to the usual two-parameter quantum superalgebra U{sub r,s}(osp(1|2n)) of osp(1|2n). We also discuss the basis of wU{sub r,s}{sup d}(osp(1|2n)) by Lusztig's symmetries.

ATLAS Cloud R&D

CERN Document Server

Panitkin, S; The ATLAS collaboration; Caballero Bejar, J; Benjamin, D; DiGirolamo, A; Gable, I; Hendrix, V; Hover, J; Kucharczuk, K; Medrano LLamas, R; Love, P; Ohman, H; Paterson, M; Sobie, R; Taylor, R; Walker, R; Zaytsev, A

2014-01-01

The computing model of the ATLAS experiment was designed around the concept of grid computing and, since the start of data taking, this model has proven very successful. However, new cloud computing technologies bring attractive features to improve the operations and elasticity of scientific distributed computing. ATLAS sees grid and cloud computing as complementary technologies that will coexist at different levels of resource abstraction, and two years ago created an R&D working group to investigate the different integration scenarios. The ATLAS Cloud Computing R&D has been able to demonstrate the feasibility of offloading work from grid to cloud sites and, as of today, is able to integrate transparently various cloud resources into the PanDA workload management system. The ATLAS Cloud Computing R&D is operating various PanDA queues on private and public resources and has provided several hundred thousand CPU days to the experiment. As a result, the ATLAS Cloud Computing R&D group has gained...

A parametric study of quasi-2D LES on Low-Reynolds-number transitional flows past an airfoil

Energy Technology Data Exchange (ETDEWEB)

Yuan, W.; Xu, H.; Khalid, M. [National Research Council (NRC), Inst. for Aerospace Research (IAR), Ottawa, Ontario (Canada)]. E-mail: Weixing.Yuan@nrc-cnrc.gc.ca

2004-07-01

Low-Reynolds-number aerodynamic performance of small sized air vehicles is an area of increasing interest. In this study, we investigate low-Reynolds-number flows past an SD7003 airfoil to understand substantial viscous features of laminar separation and transitional flow followed by the intractable behavior of reattachment. In order to satisfy the three-dimensional (3D) requirement of the code, a simple '3D wing' is constructed from a two-dimensional (2D) airfoil and only four grid points are used in the spanwise direction. A parametric study of quasi-2D LES on the low-Reynolds-number airfoil flows at Re=60000 is performed. Effects of grid resolution and sub-grid scale (SGS) models are investigated. Although three-dimensional effects cannot be accurately captured, the quasi-2D LES calculations do reveal some important flow characteristics such as leading edge laminar separation and vortex shedding from the primary laminar separation bubble on the low-Reynolds-number airfoil. (author)

Submission of scientifically sound and ethical manuscripts to peer-reviewed journals - a reviewer's personal perspective on bioanalytical publications.

Science.gov (United States)

Weng, Naidong

2012-11-01

In the pharmaceutical industry, bioanalysis is very dynamic and is probably one of the few fields of research covering the entire drug discovery, development and post-marketing process. Important decisions on drug safety can partially rely on bioanalytical data, which therefore can be subject to regulatory scrutiny. Bioanalytical scientists have historically contributed significant numbers of scientific manuscripts in many peer-reviewed analytical journals. All of these journals provide some high-level instructions, but they also leave sufficient flexibility for reviewers to perform independent critique and offer recommendations for each submitted manuscript. Reviewers play a pivotal role in the process of bioanalytical publication to ensure the publication of high-quality manuscripts in a timely fashion. Their efforts usually lead to improved manuscripts. However, it has to be a joint effort among authors, reviewers and editors to promote scientifically sound and ethically fair bioanalytical publications. Most of the submitted manuscripts were well written with only minor or moderate revisions required for further improvement. Nevertheless, there were small numbers of submitted manuscripts that did not meet the requirements for publications because of scientific or ethical deficiencies, which are discussed in this Letter to the Editor. Copyright © 2012 John Wiley & Sons, Ltd.

An R&D Management Framework for Eco-Technology

Directory of Open Access Journals (Sweden)

Kenji Sano

2011-08-01

Full Text Available Although research and development (R&D affects new value-added creation, including that related to environmental aspects, there is little literature dealing with the integration of R&D management and eco-value. Here, eco-value of technology is defined as the advantage of environmental competitiveness in the market. This paper proposes a framework of R&D management of eco-technology (RDMOET, consisting of: (1 future research for sustainability; (2 making an original eco-theme portfolio and roadmap; (3 gap analysis and implementation of new eco-themes; and (4 eco-value evaluation. (1 and (4 are new processes compared with conventional R&D management. Through practice at the Corporate R&D Center of Toshiba Corporation, the usefulness of the proposed framework is verified from the viewpoint of not only technological eco-innovation, but also that of organizational learning for environmental sustainability.

Smart Grid R&D SSM KIER FY17 Report.

Energy Technology Data Exchange (ETDEWEB)

Wilson, David G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cook, Marvin A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-12-01

This report summarizes collaborative efforts between Secure Scalable Microgrid and Korean Institute of Energy Research team members . The efforts aim to advance microgrid research and development towards the efficient utilization of networked microgrids . The collaboration resulted in the identification of experimental and real time simulation capabilities that may be leveraged for networked microgrids research, development, and demonstration . Additional research was performed to support the demonstration of control techniques within real time simulation and with hardware in the loop for DC microgrids .

Couplings in D(2,1;α) superconformal mechanics from the SU(2) perspective

Energy Technology Data Exchange (ETDEWEB)

Galajinsky, Anton [Laboratory of Mathematical Physics, Tomsk Polytechnic University,Lenin Ave. 30, 634050 Tomsk (Russian Federation)

2017-03-09

Dynamical realizations of the most general N=4 superconformal group in one dimension D(2,1;α) are reconsidered from the perspective of the R-symmetry subgroup SU(2). It is shown that any realization of the R-symmetry subalgebra in some phase space can be extended to a representation of the Lie superalgebra corresponding to D(2,1;α). Novel couplings of arbitrary number of supermultiplets of the type (1,4,3) and (0,4,4) to a single supermultiplet of either the type (3,4,1), or (4,4,0) are constructed. D(2,1;α) superconformal mechanics describing superparticles propagating near the horizon of the extreme Reissner-Nordström-AdS-dS black hole in four and five dimensions is considered. The parameter α is linked to the cosmological constant.

Synthesis of 2-(2-R1-Hydrazino-5-(R2-benzyl-2-thiazolines on the Basis of Meerweins Arylation Products of Allyl Isothiocyanate

Directory of Open Access Journals (Sweden)

Mykola I. Ganushchak

2003-02-01

Full Text Available 3-Aryl-2-chloropropylisothiocyanates (1 are formed by interaction of arenediazonium chlorides with allyl isothiocyanate. Adducts 1 react with monoacylhydrazines to form 1-acyl-4-(3-aryl-2-chloropropylthiosemicarbazides (2a–d. Thiosemicarbazides 2a–d in the presence of bases selectively transform into 2-(2-R1-hydrazino-5-(R2-benzyl-2-thiazolines (3a–d.

The forgotten R and D budget

International Nuclear Information System (INIS)

Hunt, R.; Mohsberg, J.

1992-01-01

The research and development budget for hydropower has dwindled in recent years. Increased R and D funding could improve hydropower's effectiveness. Of the $1.5 trillion US budget for 1992, only $1 million was devoted to research and development (R and D) for hydroelectric generation. This is because hydropower has been branded a mature technology no longer in need of R and D. Nevertheless, as the source of nearly 10 percent of all US electricity, hydropower offers the nation's best opportunity for significant increased renewable energy production in the near future. The US Department of Energy (DOE) has estimated an additional 50,000 MW of hydropower capacity is potentially developable. Of the total $3 billion R and D budget for all DOE programs in 1992, the combined R and D amount for the other primary renewable energy resources was $161.3 million. Whether mature or not, all methods of producing electricity have attendant problems and development needs that must be addressed with sufficient R and D if the US is to remain energy independent, competitive and safe as a nation. In comparing R and D budget trends for electrical generating resources during the past 10 years there are several questions to be asked: Are other mature technologies, such as coal and nuclear power, receiving budget treatment similar to hydropower? What is the intended use of the R and D funds for these mature technologies? Is any technology - medical, communications, electrical generating or other - ever so mature as to be unable to benefit from R and D? What use could the hydropower industry make of additional R and D funding? What is the commitment of the administration and Congress to developing renewable energy resources when the source of 85 percent of current renewable energy receives only $1 million for R and D of the $3 billion DOE R and D budget? This article addresses these questions

Árni Magnússon's rearrangement of paper manuscripts

DEFF Research Database (Denmark)

Stegmann, Beeke

Árni Magnússon’s rearrangement of paper manuscripts draws attention to the early history of Árni Magnússon’s (1663-1730) manuscript collection. The thesis examines Árni’s extensive rearrangement of paper manuscripts, showing that he repeatedly altered the physical composition of codices in his...

Help the desk: an SSM investigation

Directory of Open Access Journals (Sweden)

Fabio Di Certo

2016-05-01

Full Text Available This is case study about a groupware system adoption that, despite the efforts beyond the technical aspects, did not led to the expected improvements. Through a SSM (Soft System Methodology process of inquiry, a consistent pattern of social involvement needs emerges. The generalisable lesson deduced from the findings is that a system is more profitable - or at least more difficult to be opposed - when participated and agreed in its parts. Yet, this may not suffice: as change sometimes needs to be imposed, divergent and never stable-for-too-long standpoints always exist, incentive devices are effective in enforce the above and conduct the actor’s actions towards a wanted path.

Image Segmentation of Historical Handwriting from Palm Leaf Manuscripts

Science.gov (United States)

Surinta, Olarik; Chamchong, Rapeeporn

Palm leaf manuscripts were one of the earliest forms of written media and were used in Southeast Asia to store early written knowledge about subjects such as medicine, Buddhist doctrine and astrology. Therefore, historical handwritten palm leaf manuscripts are important for people who like to learn about historical documents, because we can learn more experience from them. This paper presents an image segmentation of historical handwriting from palm leaf manuscripts. The process is composed of three steps: 1) background elimination to separate text and background by Otsu's algorithm 2) line segmentation and 3) character segmentation by histogram of image. The end result is the character's image. The results from this research may be applied to optical character recognition (OCR) in the future.

R & D for Indian coal industry - the new agenda

Energy Technology Data Exchange (ETDEWEB)

Ghose, A.K. [Bengal Engineering College, Howrah (India). Dept. of Mining and Geology

1996-07-01

In this paper, an outline of and the R & D agenda for the Indian coal industry, highlighting the national priorities, is suggested. To prepare a viable R & D activity for the coal industry it is necessary to examine, through a priority analysis, the attractiveness and feasibility of research areas which could make significant contributions to the future of Indian coal industry. While meaningful measures per se are difficult to identify, the following criteria may form the basis of such a screening procedure: (1)level of maturity of the existing technology; (2) cost-benefit ratio of R & D; (3) impact on productivity due to incremental changes arising from R & D efforts; and (4) technological maturity of the industry to apply, adopt or adapt the results of R & D. In assessing the overall objectives of any specific portfolio of R & D projects, the costs, time-frame, and benefits will be the prime determinants of the attractiveness. It is necessary to consider both the potential beneficial impacts of a successful R & D programme and also the probability of success within a reasonable time-frame.

Differentiation of Forebrain and Hippocampal Dopamine 1-Class Receptors, D1R and D5R, in Spatial Learning and Memory

Science.gov (United States)

Sariñana, Joshua; Tonegawa, Susumu

2017-01-01

Activation of prefrontal cortical (PFC), striatal, and hippocampal dopamine 1-class receptors (D1R and D5R) is necessary for normal spatial information processing. Yet the precise role of the D1R versus the D5R in the aforementioned structures, and their specific contribution to the water-maze spatial learning task remains unknown. D1R- and D5R- specific in situ hybridization probes showed that forebrain restricted D1R and D5R KO mice (F-D1R/D5R KO) displayed D1R mRNA deletion in the medial (m)PFC, dorsal and ventral striatum, and the dentate gyrus (DG) of the hippocampus. D5R mRNA deletion was limited to the mPFC, the CA1 and DG hippocampal subregions. F-D1R/D5R KO mice were given water-maze training and displayed subtle spatial latency differences between genotypes and spatial memory deficits during both regular and reversal training. To differentiate forebrain D1R from D5R activation, forebrain restricted D1R KO (F-D1R KO) and D5R KO (F-D5R KO) mice were trained on the water-maze task. F-D1R KO animals exhibited escape latency deficits throughout regular and reversal training as well as spatial memory deficits during reversal training. F-D1R KO mice also showed perseverative behavior during the reversal spatial memory probe test. In contrast, F-D5R KO animals did not present observable deficits on the water-maze task. Because F-D1R KO mice showed water-maze deficits we tested the necessity of hippocampal D1R activation for spatial learning and memory. We trained DG restricted D1R KO (DG-D1R KO) mice on the water-maze task. DG-D1R KO mice did not present detectable spatial memory deficit, but did show subtle deficits during specific days of training. Our data provides evidence that forebrain D5R activation plays a unique role in spatial learning and memory in conjunction with D1R activation. Moreover, these data suggest that mPFC and striatal, but not DG D1R activation are essential for spatial learning and memory. PMID:26174222

Summary of findings of the R&D committee

Energy Technology Data Exchange (ETDEWEB)

Kenley, C.R. [Lockheed Martin Idaho Technologies, Idaho Falls (United States); Kokenge, B.R. [BRK Associates Inc., Farmersville, OH (United States)

1996-05-01

In March 1995, the Department of Energy`s (DOE) Nuclear Materials Stabilization Task Group (NMST) chartered a committee to formulate a research and development (R&D) plan in response to Sub-recommendation (2) of Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1. The NMSTG was established as an organizational unit operating under the auspices of the DOE Office of the Environmental Management. As a result of its efforts, the Research Committee concluded that, in general, the technology needs for stabilizing 94-1 nuclear materials are being adequately met by existing or planned DOE programs. At the same time, the committee, in the form of recommendations, noted specific R&D program areas that should be addressed by the NMSTG. These recommendations are documented in the R&D plan and formulated based on: (1) existing {open_quotes}gaps{close_quotes} in DOE`s R&D stabilization program, (2) the relative maturity of various technologies, and (3) other important R&D program issues that, in the judgement of the committee, should be addressed by the NMSTG. A systems engineering approach, derived form the aerospace industry, was applied to the various stabilization technologies to assess their relative maturity and availability for use in treating 94-1 nuclear materials.

Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytes.

LENUS (Irish Health Repository)

Matsumoto, K

1990-02-01

The effect of 1,24R-dihydroxyvitamin D3 (1,24R(OH)2D3), a synthetic analogue of a biologically active form of vitamin D3 (1,25-dihydroxyvitamin D3, 1,25(OH)2D3), on the growth of human keratinocytes cultured in serum-free medium was investigated. The growth of cultured normal human keratinocytes was inhibited by 65% by 10(-8)M 1,24R(OH)2D3 and by 90% by 10(-7)M 1,24(OH)2D3. It inhibited cell growth almost completely at 10(-6)M. The DNA synthesis of keratinocytes was also inhibited with 1,24R(OH)2D3 by 27% at 10(-8)M, 59% at 10(-7)M, and 92% at 10(-6)M. The inhibition of cell growth and DNA synthesis were more remarkable by 1,24R(OH)2D3 than by 1,25(OH)2D3. 1,24R(OH)2D3 also inhibited the growth of keratinocytes derived from patients with psoriasis vulgaris; the growth inhibitory effect was again more remarkable with 1,24R(OH)2D3 than with 1,25(OH)2D3. The viability and protein synthesis of keratinocytes were not affected by 1,24R(OH)2D3, suggesting that the growth inhibitory effect is due to its biological activity, not to cytotoxicity. The binding of [3H]-labeled 1,25(OH)2D3 to its receptor in the cytosolic fraction of cultured keratinocytes was competitively substituted by unlabeled 1,24R(OH)2D3 as well as 1,25(OH)2D3, suggesting that 1,24R(OH)2D3 binds to the 1,25(OH)2D3 receptor. It was found that the affinity of 1,24R(OH)2D3 for the receptor was slightly higher than that of 1,25(OH)2D3. These results demonstrate that 1,24R(OH)2D3 functions as a potent growth inhibitor in vitro in human keratinocytes from both normal and psoriatic epidermis, and it possesses a higher affinity for the 1,25(OH)2D3 receptor in cultured human keratinocytes. The difference in affinity of 1,24R(OH)2D3 for the 1,25(OH)2D3 receptor correlates with its greater inhibition of keratinocyte growth than 1,25(OH)2D3. 1,24R(OH)2D3 may be useful in the treatment of psoriasis.

Neutrino Factory and Muon Collider Collaboration R and D Program

International Nuclear Information System (INIS)

Zisman, M.S.

2000-01-01

The Neutrino Factory and Muon Collider Collaboration (MC) comprises some 140 scientists and engineers located at U.S. National Laboratories and Universities, and at a number of non-U.S. research institutions. In the past year, the MC R and D program has shifted its focus mainly toward the design issues related to the development of a Neutrino Factory based on a muon storage ring. In this paper the status of the various R and D activities is described, and future plans are outlined

Dopamine D2 receptors and alpha1-adrenoceptors synergistically modulate locomotion and behavior of rats in a place avoidance task

Czech Academy of Sciences Publication Activity Database

Stuchlík, Aleš; Petrásek, Tomáš; Valeš, Karel

2008-01-01

Roč. 189, č. 1 (2008), s. 139-144 ISSN 0166-4328 R&D Projects: GA ČR(CZ) GA309/07/0341; GA MZd(CZ) NR9178; GA MŠk(CZ) 1M0517; GA MŠk(CZ) LC554 Institutional research plan: CEZ:AV0Z50110509 Keywords : D2 receptors * alpha1-adrenoceptors * behavior Subject RIV: FH - Neurology Impact factor: 3.171, year: 2008

Catalogue of Korean manuscripts and rare books

DEFF Research Database (Denmark)

Lerbæk Pedersen, Bent

2014-01-01

Catalogue of Korean manuscripts and rare books in The Royal Library, Copenhagen and the National Museum of Denmark......Catalogue of Korean manuscripts and rare books in The Royal Library, Copenhagen and the National Museum of Denmark...

The returns to foreign R&D

NARCIS (Netherlands)

Belderbos, R.A.; Lokshin, B.; Sadowski, B.

2015-01-01

Extant research on R&D internationalization has not examined how effective foreign R&D investments are in generating positive returns for the investing firms, in particular in comparison and conjunction with the effects of domestic R&D investments. We examine the effectiveness of international

Opportunities and challenges for use of SSM forming in the aerospace industry

CSIR Research Space (South Africa)

Chou, HN

2006-01-01

Full Text Available to aerospace applications. SSM processing does demonstrate the potential to replace certain hogout components in commercial aircraft with the main aim to reduce costs while maintaining high strength to weight ratios. In order to achieve this it will require...

Captive R&D Offshoring

DEFF Research Database (Denmark)

Søberg, Peder Veng

This PhD thesis includes four journal papers and one book chapter, which investigate how newly established foreign-invested R&D units in emerging markets become able to carry out their mandates. In particular, the author investigates how the employees of such units acquire R&D home base knowledge...... Scandinavia and now operating in Scandinavia, China, and India. The thesis questions an assumption in the Uppsala model, which implies that different business activities can be internationalized in the same way. The findings point to the importance of socialization across the R&D home base and newly...... that the local talent in China and India is particularly suited to improving existing products and processes. However, due to a lack of social initiative, it is more difficult to use this talent to identify and solve entirely new problems. The thesis also investigates how local sources of knowledge are engaged...

AAS Publishing News: Preparing Your Manuscript Just Got Easier

Science.gov (United States)

Kohler, Susanna

2016-03-01

Watermarking using the command watermark{DRAFT, v2}.Are you an astronomer considering submitting a paper to an AAS journal (i.e., AJ, ApJ, ApJ Letters, or ApJ Supplements)? If so, this post is for you! Read on to find out about the exciting new things you can do with the AASs newest LaTeX class file, available for download now.Why the Update?AAS publishing has maintained a consistent class file for LaTeX manuscript preparation for the past decade. But academic publishing is changing rapidly in todays era of electronic journals! Since its journals went fully electronic, the AAS has been continuously adding new publishing capabilities based on the recommendations of the Journals Task Force and the needs and requests of AAS authors. The AASs manuscript preparation tools are now being updated accordingly.Whats New in AASTex 6.0?There are many exciting new features and capabilities in AASTex 6.0. Here are just a few:Tracking options for author revisions include added{text}, deleted{text}, replaced{old}{new}, and explain{text}.Based on emulateapjDo you use the popular class file emulateapj to prepare your manuscripts? AASTex 6.0 is based on emulateapj, rather than on the older AASTex 5.2 (though 5.2 is still supported). This means that it is easy to produce a double-columned, single-spaced, and astro-ph-ready manuscript. Since two thirds of the AAS journals authors use emulateapj, this transition was designed to make manuscript preparation and sharing an easier and more seamless process.Tools for collaborationsDo you work in a large collaboration? AASTex now includes new tools to make preparing a manuscript within a collaboration easier. Drafts can now be watermarked to differentiate between versions. New markup for large author lists streamlines the display so that readers can access article information immediately, yet they can still access the full author list and affiliations at the end of the paper. And author revision markup allows members of a collaboration to

Seahorse Manuscript Data Set

Data.gov (United States)

U.S. Environmental Protection Agency — Metadata for figures presented in manuscript reporting bioenergetic effects of exposure to environmentally relevant organic compound in human airway epithelial...

Recent Korean R&D in Satellite Communications

Science.gov (United States)

Lee, Ho-Jin; Kim, Jae Moung; Lee, Byung-Seub; Lee, Han; Ryoo, Jang-Soo

The R&D in satellite communications in Korea has been driven mainly by KCC (Korea Communications Commission) but in a small scale compared to Korea space development program organized by MEST (Ministry of Education, Science and Technology). Public and civilian satcom sector R&D has been led mainly by ETRI with small/medium companies contrary to rare investment in private sector while military sector R&D has been orchestrated by ADD with defense industry. By the COMS (Communication, Ocean and Meteorological Satellite) experimental Ka-band payload, Korea pursues a space qualification of own technology for national infrastructure evolution as well as industrialization of space R&D results. Once COMS launched and space qualified in 2009, subsequent application experiments and new technology R&D like UHDTV will entail service and industry promotion. The payload technology is expected for the next Korean commercial satellites or for new OBP satellites. The COMS ground control system and GNSS ground station technologies are under development for COMS operation and enhanced GNSS services along with advent of Galileo respectively. Satellite broadband mobile VSAT based on DVB-S2/RCS (+M) and low profile tracking antennas have been developed for trains, ships, and planes. While APSI is developing GMR-1 based Thuraya handset functions, ETRI is designing IMT-Advanced satellite radio interface for satellite and terrestrial dual-mode handheld communication system like Japanese STICS, with universities' satellite OFDM researches. A 21GHz Ka-band higher-availability scalable HD broadcasting technology and SkyLife's hybrid satellite IPTV technology are being developed. In near term Korea will extend R&D programs to upgrade the space communication infrastructure for universal access to digital opportunity and safer daily life from disaster, and to promote space green IT industrialization, national security, and space resources sovereign. Japanese stakeholders are invited to establish

Crowdsourced 'R&D' and medical research.

Science.gov (United States)

Callaghan, Christian William

2015-09-01

Crowdsourced R&D, a research methodology increasingly applied to medical research, has properties well suited to large-scale medical data collection and analysis, as well as enabling rapid research responses to crises such as disease outbreaks. Multidisciplinary literature offers diverse perspectives of crowdsourced R&D as a useful large-scale medical data collection and research problem-solving methodology. Crowdsourced R&D has demonstrated 'proof of concept' in a host of different biomedical research applications. A wide range of quality and ethical issues relate to crowdsourced R&D. The rapid growth in applications of crowdsourced R&D in medical research is predicted by an increasing body of multidisciplinary theory. Further research in areas such as artificial intelligence may allow better coordination and management of the high volumes of medical data and problem-solving inputs generated by the crowdsourced R&D process. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Scientific composition and review of manuscripts for publication in peer-reviewed dental journals.

Science.gov (United States)

Bayne, Stephen C; McGivney, Glen P; Mazer, Sarah C

2003-02-01

This article provides an extensive tutorial for writers and reviewers involved with the preparation and evaluation of manuscripts submitted for publication in dental journals. The contents were compiled from the Instructions for Authors printed in various peer-reviewed dental journals and from feedback from 10 workshops conducted for the Editorial Review Board of the Journal of Prosthetic Dentistry. The 10 major sections of a scientific manuscript are reviewed in detail in terms of content, format, and common errors; examples of good content are provided. The review process is described, and instructions on conducting fair and expeditious manuscript evaluations are provided for reviewers. In addition, a number of special topics are addressed, including potential conflicts of interest for an author, institutional review of experiments that involve human subjects or animals, and the reproduction of photographs and other images in color versus black and white. In summary, this article presents key guidelines to ensure compliance with the principles of sound scientific writing and the expeditious review of manuscripts prepared for publication in peer-reviewed dental journals.

Inter-firm R&D partnering in pharmaceutical biotechnology since 1975 : trends, patterns, and networks

NARCIS (Netherlands)

Roijakkers, A.H.W.M.; Hagedoorn, J.

2006-01-01

This paper analyses a large, longitudinal database on inter-firm R&D partnerships formed in the high-tech pharmaceutical biotechnology industry since 1975. Our research indicates an overall growth in the number of annually, newly established R&D partnerships where research partners consistently

IGORR-IV workshop on R and D needs

International Nuclear Information System (INIS)

Boening, Klaus

1995-01-01

The IGORR-IV Workshop on R and D Needs, which is the subject of this summarizing paper, provided the opportunity for the participants to report on new R and D needs they have as well as on R and D work which was going on at their home institutions ad which could be of interest to other groups. Numerous topics of interest are: Accident and safety analysis codes and benchmarks; thermophysical properties of D 2 O liquid and vapor; chemical and other energy release from core melt event; Fission product release from a molten MTR core; Thermal conductivity of irradiated fuel; tests of cryogenic circulators for single-phase forced-convection cold source; Flow blockage tests

Magnetic phase transitions in R2Fe17 compounds under pressure

International Nuclear Information System (INIS)

Arnold, Z.; Kamarad, J.

1994-01-01

The effect of the pressure up to 1.4 GPa on the Curie temperature T c in the R 2 Fe 17 intermetallics with R = Nd, Er and Y was measured using a low field susceptibility technique. The identical character of the temperature dependence of susceptibility χ(T) of the R 2 Fe 17 intermetallics observed at ambient pressure (sharp step-like drop at T c ) is preserved at high pressures only in the case of Nd 2 Fe 17 . Pronounced broadening and splitting of the sharp drop of χ(T) was observed in Er 2 Fe 17 and Y 2 Fe 17 respectively. The initial pressure slopes of dTc/dp are large and negative for all studied compounds, having nearly the same values (dTc/dp = -36K/GPa for Nd 2 Fe 17 compound). The results are discussed from the point of view of the sensitivity of T c on the crystal structure, the number of nearest neighbors of Fe atoms and the possible effect of disordered structures in the R 2 Fe 17 intermetallics

Simultaneous explanation of the RK and R (D (*)) puzzles

Science.gov (United States)

Bhattacharya, Bhubanjyoti; Datta, Alakabha; London, David; Shivashankara, Shanmuka

2015-03-01

At present, there are several hints of lepton flavor non-universality. The LHCb Collaboration has measured RK ≡ B (B+ →K+μ+μ-) / B (B+ →K+e+e-), and the BaBar Collaboration has measured R (D (*)) ≡ B (B bar →D (*) +τ-νbarτ) / B (B bar →D (*) +ℓ-νbarℓ) (ℓ = e , μ). In all cases, the experimental results differ from the standard model predictions by 2- 3 σ. Recently, an explanation of the RK puzzle was proposed in which new physics (NP) generates a neutral-current operator involving only third-generation particles. Now, assuming the scale of NP is much larger than the weak scale, this NP operator must be made invariant under the full SU (3)C × SU (2)L × U(1)Y gauge group. In this Letter, we note that, when this is done, a new charged-current operator can appear, and this can explain the R (D (*)) puzzle. A more precise measurement of the double ratio R (D) / R (D*) can rule out this model.

Center type performance of differentiable vector fields in R2

International Nuclear Information System (INIS)

Rabanal, Roland

2007-08-01

Let X : R 2 / D → R 2 be a differentiable vector field, where D is compact. If the eigenvalues of the jacobian matrix DX z are (nonzero) purely imaginary, for all z element of R 2 / D . Then, X + v has a center type performance at infinity, for some v element of R 2 . More precisely, X + v has a periodic trajectory Γ subset of R2/ D which is surrounding D such that in the unbounded component of (R 2 / D )/ Γ all the trajectories of X + v are nontrivial cycles. In the case of global vector fields Y : R 2 → R 2 with Y (0) = 0, we prove that such eigenvalue condition implies the topological equivalency of Y with the linear vector field (x, y) → (-y, x). (author)

Theory of small atomic-like 2D dust clusters

International Nuclear Information System (INIS)

Amiranashvili, Sh.G.; Gousein-zade, N.G.; Tsytovich, V.N.

2002-01-01

In several experiments atom-like dust clusters with parabolic confining potential were observed [1-3]. Here we present a general theory of 2D clusters confined by (1/2)m dω 0 2 r2 potential with arbitrary pair interaction potential depending on the inter-dust distance. It describes the equilibrium conditions, normal modes, their frequencies and possible instabilities of clusters with arbitrary N number of grains. The mono-layer clusters can have 2N frequencies of oscillations in the cluster plane among which 3 modes are trivial (ω = 0 and double degenerate frequency of oscillation in the potential well). The 2N - 3 non-trivial modes are considered. For example, for square dust cluster with potential V(r) the equilibrium is described by ω 0 2 = -(4/m) [V'(√(2)R) + V'(2R)], the frequency of radial oscillations is ω2 = (16R2/m) [V''(√(2)R) + 2V''(2R)], the two single modes frequencies are ω2 (32R2/m)V''(2R); ω2 = (16R2/m)V''(√(2)r) and one double degenerated mode frequency is ω2 = (1/m) [V'√(2)R) - V'(2R) + 4R2V''(√(2)R)] where ' corresponds to the differentiation of the potential V(r) with respect to √(r). The general stability criterion was found and investigated for N ≥ 4. The pair interaction potential V(r) is considered as a sum of different attraction and repulsion terms , including that which describe the non-screened collective and non collective attraction, the screened non-Coulomb interaction and the non-screened repulsion. The collective non-screened potential causes the absence of equilibria at certain dust cluster sizes. For screened Coulomb potential Vc(r) = (Z d 2 e2αscr/r)exp(-r/λscr) the clusters with the size R are considered. The pentagon cluster is found to be stable for R < 3.3λscr and the clusters with N ≥ 6 are found to be always unstable. The measurements of the frequencies of the cluster modes, the thresholds of cluster equilibria and the stability of the clusters can be used for detection of the dust

Heavy water production benefits of a supporting r and d program

International Nuclear Information System (INIS)

Bancroft, A.R.; Chuang, K.T.; Dalrymple, D.G.

1981-01-01

Considerable economic benefit was obtained from an active R and D program while the Canadian heavy water plants were brought to mature operation during the 1970s. The introduction to Canada of this new chemical processing industry led to unexpected process, equipment and materials problems. Having a small team of technical experts already working on heavy water processes and a much larger R and D team working in related fields allowed a rapid response to the problems that limited production. The number of engineers and scientists working on the GS process rose rapidly from a skeleton team in 1970 to 54 during 1974. Effort declined steadily as the major problems were solved and reached 22 by 1980. Cumulative effort over the decade was 264 man-years at a cost of 3.3 percent of the value of the heavy water produced. The new production benefits have lagged behind the R and D expenditure by a few years and the current spending rate is 1.2 percent of product value. Important contributions were made in the areas of process simulation, process chemistry, materials of construction, sieve trays, and mechanical equipment

Managing R&D and New Product Development

NARCIS (Netherlands)

von Zedtwitz, Maximilian; Friesike, Sascha; Gassmann, Oliver; Dodgson, Mark; Gann, David M.; Phillips, Nelson

2014-01-01

This article examines the importance of R&D and new product development and explores their management. It describes three central aspects of managing R&D and new product development in firms: the product development funnel, R&D portfolio management, and R&D organization. Concepts such as the ‘fuzzy

Irish Culinary Manuscripts and Printed Books:a Discussion

OpenAIRE

Mac Con Iomaire, Máirtín; Cashman, Dorothy

2011-01-01

This paper provides a discussion of Irish Culinary Manuscripts and Printed Cookbooks. It covers Gaelic hospitality and aristocratic hospitality, setting the background for the Anglo-Irish households from which many manuscripts emerge. It charts the growing sources of information on Irish culinary history. It outlines Barbara Wheaton's framework for reading historic cookbooks and discusses the growing manuscript cookbook collection in the National Library of Ireland.

Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring

Energy Technology Data Exchange (ETDEWEB)

Mountassif, Driss; Fabre, Lucien [Department of Anatomy and Cell Biology, McGill University, Groupe de recherche axé sur la structure des protéines (GRASP), Groupe d' Étude des Proteines Membranaires (GÉPROM), 3640 University Street, Montreal H3A 0C7 (Canada); Zaid, Younes [Department of Anatomy and Cell Biology, McGill University, Groupe de recherche axé sur la structure des protéines (GRASP), Groupe d' Étude des Proteines Membranaires (GÉPROM), 3640 University Street, Montreal H3A 0C7 (Canada); Current address: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec (Canada); Halawani, Dalia [Department of Anatomy and Cell Biology, McGill University, Groupe de recherche axé sur la structure des protéines (GRASP), Groupe d' Étude des Proteines Membranaires (GÉPROM), 3640 University Street, Montreal H3A 0C7 (Canada); Current address: Department of Cell Biology, Lerner Research Institute, 9500 Euclid Avenue NC10, Cleveland, OH 44195 (United States); Rouiller, Isabelle, E-mail: isabelle.rouiller@mcgill.ca [Department of Anatomy and Cell Biology, McGill University, Groupe de recherche axé sur la structure des protéines (GRASP), Groupe d' Étude des Proteines Membranaires (GÉPROM), 3640 University Street, Montreal H3A 0C7 (Canada)

2015-12-25

Single amino acid mutations in valosin containing protein (VCP/p97), a highly conserved member of the ATPases associated with diverse cellular activities (AAA) family of ATPases has been linked to a severe degenerative disease affecting brain, muscle and bone tissue. Previous studies have demonstrated the role of VCP mutations in altering the ATPase activity of the D2 ring; however the structural consequences of these mutations remain unclear. In this study, we report the three-dimensional (3D) map of the pathogenic VCP variant, R155P, as revealed by single-particle Cryo-Electron Microscopy (EM) analysis at 14 Å resolution. We show that the N-terminal R155P mutation induces a large structural reorganisation of the D2 ATPase ring. Results from docking studies using crystal structure data of available wild-type VCP in the EM density maps indicate that the major difference is localized at the interface between two protomers within the D2 ring. Consistent with a conformational change, the VCP R155P variant shifted the isoelectric point of the protein and reduced its interaction with its well-characterized cofactor, nuclear protein localization-4 (Npl4). Together, our results demonstrate that a single amino acid substitution in the N-terminal domain can relay long-range conformational changes to the distal D2 ATPase ring. Our results provide the first structural clues of how VCP mutations may influence the activity and function of the D2 ATPase ring. - Highlights: • p97{sub R155P} and p97{sub A232E} decrease the ability of p97 to bind to its co-factor Npl4. • p97{sub R155P} has a different isoelectric point than that of p97{sub R95G}, p97{sub A232E} and p97{sub WT}. • Mutation R155P changes principally the conformation of the D2 ring. • Mutation R155P modifies the interface between two protomers within the D2 ring.

Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring

International Nuclear Information System (INIS)

Mountassif, Driss; Fabre, Lucien; Zaid, Younes; Halawani, Dalia; Rouiller, Isabelle

2015-01-01

Single amino acid mutations in valosin containing protein (VCP/p97), a highly conserved member of the ATPases associated with diverse cellular activities (AAA) family of ATPases has been linked to a severe degenerative disease affecting brain, muscle and bone tissue. Previous studies have demonstrated the role of VCP mutations in altering the ATPase activity of the D2 ring; however the structural consequences of these mutations remain unclear. In this study, we report the three-dimensional (3D) map of the pathogenic VCP variant, R155P, as revealed by single-particle Cryo-Electron Microscopy (EM) analysis at 14 Å resolution. We show that the N-terminal R155P mutation induces a large structural reorganisation of the D2 ATPase ring. Results from docking studies using crystal structure data of available wild-type VCP in the EM density maps indicate that the major difference is localized at the interface between two protomers within the D2 ring. Consistent with a conformational change, the VCP R155P variant shifted the isoelectric point of the protein and reduced its interaction with its well-characterized cofactor, nuclear protein localization-4 (Npl4). Together, our results demonstrate that a single amino acid substitution in the N-terminal domain can relay long-range conformational changes to the distal D2 ATPase ring. Our results provide the first structural clues of how VCP mutations may influence the activity and function of the D2 ATPase ring. - Highlights: • p97 R155P and p97 A232E decrease the ability of p97 to bind to its co-factor Npl4. • p97 R155P has a different isoelectric point than that of p97 R95G , p97 A232E and p97 WT . • Mutation R155P changes principally the conformation of the D2 ring. • Mutation R155P modifies the interface between two protomers within the D2 ring.

Solid-State Lighting R&D Plan - 2016

Energy Technology Data Exchange (ETDEWEB)

None, None

2016-06-30

The SSL R&D Plan provides analysis and direction for ongoing R&D activities to advance SSL technology and increase energy savings. The R&D Plan also reviews SSL technology status and trends for both LEDs and OLEDs and offers an overview of the current DOE SSL R&D project portfolio.

The Progress of SBIR Supported R and D of Solid State Pulse Modulators

International Nuclear Information System (INIS)

Koontz, R

2004-01-01

The Small Business Innovative Research (SBIR) grant program funded by the US Department of Energy makes a number of awards each year for R and D in the field of accelerator technology including high power pulse modulators and their components. This paper outlines program requirements, and reviews some of the awards made in the last three years in support of high power modulator systems and solid state switching. A number of award recipients are presenting the results of their SBIR R and D at this workshop

HTGR R and D programs

International Nuclear Information System (INIS)

Neylan, A.J.; Brisbois, J.

1979-01-01

A significant R and D program (including in certain cases full-scale prototype tests) formed the basis for the design and key elements in the foregoing projects and is continuing to provide a basis for generic design development. HTGR R and D programs are both privately and government sponsored. This paper provides an overview of the background, current status and outstanding design issues/problems remaining in the area of NSS Plant, Materials and Fuel. The specific objectives and scope of all recently completed, ongoing and planned major HTGR R and D programs are presented

Environmental Assessment of R&D Programmes

DEFF Research Database (Denmark)

Lyhne, Ivar; Byriel, Inger Pihl

2013-01-01

cause severe negative environmental impacts. This paper presents an innovative environmental assessment practice on R&D programmes in Denmark. It reports on the challenges and experiences of assessing the Danish R&D programme ForskEL, which promotes R&D projects within the electricity sector......Despite their important role in shaping the technologies of the future, public research and development (R&D) programmes are rarely based on systematic assessments of the environmental effects. R&D programmes thus allocate a huge amount of financial resources to projects, which potentially may....... The programme is characterised by uncertainty about impacts and incomparable project types and technologies. A methodology for dealing with these challenges is presented, and experiences from a testing of the methodology on the 2012 programme are reflected upon. Finally the assessment is discussed in terms...

Astronomical knowledge transmission through illustrated Aratea manuscripts

CERN Document Server

Dolan, Marion

2017-01-01

This carefully researched monograph is a historical investigation of the illustrated Aratea astronomical manuscript and its many interpretations over the centuries. Aratus' 270 B.C.E. Greek poem describing the constellations and astrological phenomena was translated and copied over 800 years into illuminated manuscripts that preserved and illustrated these ancient stories about the constellations. The Aratea survives in its entirety due to multiple translations from Greek to Latin and even to Arabic, with many illuminated versions being commissioned over the ages. The survey encompasses four interrelated disciplines: history of literature, history of myth, history of science, and history of art. Aratea manuscripts by their nature are a meeting place of these distinct branches, and the culling of information from historical literature and from the manuscripts themselves focuses on a wider, holistic view; a narrow approach could not provide a proper prospective. What is most essential to know about this work is...

Where is practice in inter-organizational R&D research?

DEFF Research Database (Denmark)

Smith, Pernille

2012-01-01

review is based on a bibliographical search of a number of academic search engines. These sources include all the major management, organizational behavior, marketing, engineering, sociology, and psychology journals, thus ensuring a thorough search on the topic of inter-organizational R&D. The review...

77 FR 1656 - Proposed Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, R...

Science.gov (United States)

2012-01-11

...-0117; Airspace Docket No. 09-AGL-31] RIN 2120-AI92 Proposed Establishment of Restricted Areas R-5402, R-5403A, R- 5403B, R-5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND AGENCY: Federal Aviation... Restricted Areas R-5402, R-5403A, R-5403B, R- 5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND (76 FR 72869...

77 FR 36907 - Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, and R...

Science.gov (United States)

2012-06-20

...; Airspace Docket No. 09-AGL-31] Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R- 5403C, R-5403D, R-5403E, and R-5403F; Devils Lake, ND AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... establish Restricted Areas R- 5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, and R-5403F in the vicinity...

Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior

Directory of Open Access Journals (Sweden)

Toru eNakamura

2014-07-01

Full Text Available Both D1R and D2R knock out (KO mice of the major dopamine receptors show significant motor impairments. However, there are some discrepant reports, which may be due to the differences in genetic background and experimental procedures. In addition, only few studies directly compared the motor performance of D1R and D2R KO mice. In this paper, we examined the behavioral difference among N10 congenic D1R and D2R KO, and wild type (WT mice. First, we examined spontaneous motor activity in the home cage environment for consecutive five days. Second, we examined motor performance using the rota-rod task, a standard motor task in rodents. Third, we examined motor ability with the Step-Wheel task in which mice were trained to run in a motor-driven turning wheel adjusting their steps on foothold pegs to drink water. The results showed clear differences among the mice of three genotypes in three different types of behavior. In monitoring spontaneous motor activities, D1R and D2R KO mice showed higher and lower 24 h activities, respectively, than WT mice. In the rota-rod tasks, at a low speed, D1R KO mice showed poor performance but later improved, whereas D2R KO mice showed a good performance at early days without further improvement. When first subjected to a high speed task, the D2R KO mice showed poorer rota-rod performance at a low speed than the D1R KO mice. In the Step-Wheel task, across daily sessions, D2R KO mice increased the duration that mice run sufficiently close to the spout to drink water, and decreased time to touch the floor due to missing the peg steps and number of times the wheel was stopped, which performance was much better than that of D1R KO mice. These incongruent results between the two tasks for D1R and D2R KO mice may be due to the differences in the motivation for the rota-rod and Step-Wheel tasks, aversion- and reward-driven, respectively. The Step-Wheel system may become a useful tool for assessing the motor ability of WT

Trends in R and D reflect strategies for deregulation

International Nuclear Information System (INIS)

Anon.

1996-01-01

Whether the electric power industry is technology-driven or market-driven, research and development (R and D) will play a critical role in fomenting and cementing a utility's long-term competitive position. And as competition heats up, so will the drive for proprietary technologies, thus limiting the number of potential collaborators. From the private side of investment, R and D spending is constrained by an unpredictable future for the electric power industry. And the news is even worse for generation than other sectors of the industry. R and D money, which in the past was more narrowly focused on power generation, transmission, and distribution technologies, will be more widely spread to include technologies outside of the core business. At the very least, only those entities that plan to generate electricity can be expected to fund R and D for that purpose. Electric Power Research Institute (EPRI, Palo Alto, Calif.), the Gas Research Institute (GRI), and others are putting funds into distributed generation. GRI in particular is involved in collaborative advanced gas-turbine (CAGT) projects that studies ways to use intercooled aeroderivative-type machines. GRI sees a market for gas turbine with costs and efficiencies somewhere between today's simple- and combined-cycle configurations

Impact of R&D expenditures on research publications, patents and high-tech exports among European countries.

Science.gov (United States)

Meo, S A; Usmani, A M

2014-01-01

This study aimed to compare the impact of Research&Development (R&D) expenditures on research publications, patents and high-tech exports among European countries. In this study, 47 European countries were included. The information regarding European countries, their per capita Gross Domestic Product (GDP), R&D spending, number of universities, indexed scientific journals, high technology exports and number of patents were collected. We recorded the total number of research documents in various science and social sciences subjects during the period 1996-2011. The main source for information was World Bank, Web of Science, Thomson Reuters and SCImago/Scopus. The mean GDP per capita for all the European countries is 23372.64 ± 3588.42 US$, yearly per capita spending on R&D 1.14 ± 0.13 US$, number of universities 48.17 ± 10.26, mean number of Institute of Scientific Information (ISI) indexed journal per country 90.72 ± 38.47, high technology exports 12.86 ± 1.59 and number of patent applications 61504.23 ± 22961.85. The mean of research documents published in various science and social science subjects among all the European countries during the period 1996-2011 is 213405.70 ± 56493.04. Spending on R&D, number of universities, indexed journals, high technology exports and number of patents have a positive correlation with number of published documents in various science and social science subjects. We found a positive correlation between patent application and high-tech exports. However, there was no association between GDP per capita and research outcomes. It is concluded that, the most important contributing factors towards a knowledge based economy are spending on R&D, number of universities, scientific indexed journals and research publications, which in turn give a boast to patents, high technology exports and ultimately GDP.

EELS study of the inverse martensitic transformation of 2H and 18R Cu-Al-Zn alloys

International Nuclear Information System (INIS)

Espinosa-Magana, F.; Ochoa-Lara, M.T.; Lovey, F.; Flores-Zuniga, H.; Rios-Jara, D.

2010-01-01

Changes in 3d states occupancy associated with the inverse martensitic transformation in two samples of Cu-Al-Zn alloys with 2H and 18R martensitic structures were investigated by electron energy loss spectroscopy (EELS). The Cu L 2,3 white-lines intensities, which reflect the unoccupied density of states in 3d bands, were measured in situ, during the phase transformation in both the martensite and austenite phases. We find that the white-lines intensity decreases during the inverse transformation, when going from martensite to austenite. Even though the initial 3d occupation numbers in 2H and 18R martensitic structures are different, after the transformation, the 3d occupation numbers in the now austenitic structure have decreased in both samples, indicating that some electrons left Cu 3d bands during phase transformation. Interestingly enough, the occupation numbers in the final phases, which have the same structure, reach the same value, indicating that changes in EELS spectra are a consequence of structural changes.

EELS study of the inverse martensitic transformation of 2H and 18R Cu-Al-Zn alloys

Energy Technology Data Exchange (ETDEWEB)

Espinosa-Magana, F., E-mail: francisco.espinosa@cimav.edu.m [Centro de Investigacion en Materiales Avanzados, S.C., Laboratorio Nacional de Nanotecnologia, Miguel de Cervantes 120, Complejo Industrial Chihuahua, Chihuahua, Chih. 31109 (Mexico); Ochoa-Lara, M.T. [Centro de Investigacion en Materiales Avanzados, S.C., Laboratorio Nacional de Nanotecnologia, Miguel de Cervantes 120, Complejo Industrial Chihuahua, Chihuahua, Chih. 31109 (Mexico); Lovey, F. [Centro Atomico Bariloche, 8300 S.C. de Bariloche (Argentina); Flores-Zuniga, H. [Universidad Autonoma de Zacatecaa, Av. Lopez Velarde 801, Zacatecas, Zac. 98060 (Mexico); Rios-Jara, D. [Instituto Potosino de Investigacion Cientifica y Tecnologica, Camino a la Presa San Jose 2055, San luis Potosi, S.L.P. 78126 (Mexico)

2010-01-01

Changes in 3d states occupancy associated with the inverse martensitic transformation in two samples of Cu-Al-Zn alloys with 2H and 18R martensitic structures were investigated by electron energy loss spectroscopy (EELS). The Cu L{sub 2,3} white-lines intensities, which reflect the unoccupied density of states in 3d bands, were measured in situ, during the phase transformation in both the martensite and austenite phases. We find that the white-lines intensity decreases during the inverse transformation, when going from martensite to austenite. Even though the initial 3d occupation numbers in 2H and 18R martensitic structures are different, after the transformation, the 3d occupation numbers in the now austenitic structure have decreased in both samples, indicating that some electrons left Cu 3d bands during phase transformation. Interestingly enough, the occupation numbers in the final phases, which have the same structure, reach the same value, indicating that changes in EELS spectra are a consequence of structural changes.

Lattice dynamical investigation of the Raman and infrared wave numbers and heat capacity properties of the pyrochlores R2Zr2O7 (R = La, Nd, Sm, Eu)

Science.gov (United States)

Nandi, S.; Jana, Y. M.; Gupta, H. C.

2018-04-01

A short-range electrostatic forcefield model has been applied for the first time to investigate the Raman and infrared wave numbers in pyrochlore zirconates R2Zr2O7 (R3+ = La, Nd, Sm, Eu). The calculations of phonons involve five stretching and four bending force constants in the Wilson GF matrix method. The calculated phonon wave numbers are in reasonable agreement with the observed spectra in infrared and Raman excitation zones for all of these isomorphous compounds. The contributions of force constants to each mode show a similar trend of variation for all of these compounds. Furthermore, to validate the established forcefield model, we calculated the standard thermodynamic functions, e.g., molar heat capacity, entropy and enthalpy, and compared the results with the previous experimental data for each compound. Using the derived wave numbers for the acoustic and optical modes, the total phonon contribution to the heat capacity was calculated for all these zirconate compounds. The Schottky heat capacity contributions were also calculated for the magnetic compounds, Nd2Zr2O7, Sm2Zr2O7 and Eu2Zr2O7, taking account of crystal-field level schemes of the lanthanide ions. The derived total heat capacity and the integrated values of molar entropy and molar enthalpy showed satisfactory correlations at low temperatures with the experimental results available in the literature for these compounds. At higher temperatures, the discrepancies may be caused by the anharmonic effects of vibrations, phonon dispersion, distribution of phonon density of states, etc.

ATLAS Cloud R&D

Science.gov (United States)

Panitkin, Sergey; Barreiro Megino, Fernando; Caballero Bejar, Jose; Benjamin, Doug; Di Girolamo, Alessandro; Gable, Ian; Hendrix, Val; Hover, John; Kucharczyk, Katarzyna; Medrano Llamas, Ramon; Love, Peter; Ohman, Henrik; Paterson, Michael; Sobie, Randall; Taylor, Ryan; Walker, Rodney; Zaytsev, Alexander; Atlas Collaboration

2014-06-01

The computing model of the ATLAS experiment was designed around the concept of grid computing and, since the start of data taking, this model has proven very successful. However, new cloud computing technologies bring attractive features to improve the operations and elasticity of scientific distributed computing. ATLAS sees grid and cloud computing as complementary technologies that will coexist at different levels of resource abstraction, and two years ago created an R&D working group to investigate the different integration scenarios. The ATLAS Cloud Computing R&D has been able to demonstrate the feasibility of offloading work from grid to cloud sites and, as of today, is able to integrate transparently various cloud resources into the PanDA workload management system. The ATLAS Cloud Computing R&D is operating various PanDA queues on private and public resources and has provided several hundred thousand CPU days to the experiment. As a result, the ATLAS Cloud Computing R&D group has gained a significant insight into the cloud computing landscape and has identified points that still need to be addressed in order to fully utilize this technology. This contribution will explain the cloud integration models that are being evaluated and will discuss ATLAS' learning during the collaboration with leading commercial and academic cloud providers.

A top-down analysis: Determining photovoltaics R and D investments from patent analysis and R and D headcount

International Nuclear Information System (INIS)

Breyer, Christian; Birkner, Christian; Meiss, Jan; Goldschmidt, Jan Christoph; Riede, Moritz

2013-01-01

For alternative energy technologies like photovoltaics (PV), the analysis of Research and Development (R and D) expenses is important to observe and understand market dynamics. This is, in turn, essential for policymakers. However, the quantitative evaluation of global corporate R and D investments is a challenging task due to unavailability or high scatter of precise data. Here we present a top-down approach to estimate the current and global historic cumulated PV R and D investments based on international PV patent applications. High growth rates of PV-related patents and R and D headcount accompany growth and development of the PV market and are an excellent indicator to analyze R and D investments. With this approach, current annual corporate PV R and D investments are found to be about 6000 m€ and show a rapidly increasing trend on a global scale. - Highlights: • Global corporate and public photovoltaic R and D spendings are presented and quantified. • Instead of company reports or governmental reports, alternative metrics are developed. • Basis for quantification are photovoltaic patent applications and research headcounts. • Patents are analyzed regarding their country of origin, year of filing, type of technology. • Ethical and political implications of energy R and D are discussed

RSS SSM/I OCEAN PRODUCT GRIDS DAILY FROM DMSP F11 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — This dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor Microwave Imager Sounder (SSMIS) data products produced as part...

Resveratrol attenuates lipopolysaccharide-induced hepatitis in D-Galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1

Czech Academy of Sciences Publication Activity Database

Farghali, H.; Černý, D.; Kameníková, L.; Martínek, J.; Hořínek, A.; Kmoníčková, Eva; Zídek, Zdeněk

2009-01-01

Roč. 21, 3-4 (2009), s. 216-225 ISSN 1089-8603 R&D Projects: GA ČR GA305/07/0061 Grant - others:GA ČR(CZ) GA305/09/0004; GA MZd(CZ) NR9379 Institutional research plan: CEZ:AV0Z50390512 Keywords : resveratrol * lipopolysacchride * nitrix oxide Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 2.506, year: 2009

R2/R0-WTR decommissioning cost. Comparison and benchmarking analysis

International Nuclear Information System (INIS)

Varley, Geoff; Rusch, Chris

2001-10-01

SKI charged NAC International with the task of determining whether or not the decommissioning cost estimates of R2/R0 (hereafter simply referred to as R2) and Aagesta research reactors are reasonable. The associated work was performed in two phases. The objective in Phase I was to make global comparisons of the R2 and Aagesta decommissioning estimates with the estimates/actual costs for the decommissioning of similar research reactors in other countries. This report presents the results of the Phase II investigations. Phase II focused on selected discrete work packages within the decommissioning program of the WTR reactor. To the extent possible a comparison of those tasks with estimates for the R2 reactor has been made, as a basis for providing an opinion on the reasonableness of the R2 estimate. The specific WTR packages include: reactor vessel and internals dismantling; biological shield dismantling; primary coolant piping dismantling; electrical equipment removal; waste packaging; transportation and disposal of radioactive concrete and reactor components; project management, licensing and engineering; and removal of ancillary facilities. The specific tasks were characterised and analysed in terms of fundamental parameters including: task definition; labour hours expended; labour cost; labour productivity; length of work week; working efficiency; working environment and impact on job execution; external costs (contract labour, materials and equipment); total cost; waste volumes; and waste packaging and transport costs. Based on such detailed raw data, normalised unit resources have been derived for selected parts of the decommissioning program, as a first step towards developing benchmarking data for D and D activities at research reactors. Several general conclusions emerged from the WTR decommissioning project. Site characterisation can confirm or negate major assumptions, quantify waste volumes, delineate obstacles to completing work, provide an understanding

A comparison of porosity analysis using 2D stereology estimates and 3D serial sectioning for additively manufactured Ti 6Al 2Sn 4Zr 2Mo alloy

International Nuclear Information System (INIS)

Ganti, Satya R.; Velez, Michael A.; Geier, Brian A.; Hayes, Brian J.; Turner, Bryan J.; Jenkins, Elizabeth J.

2017-01-01

Porosity is a typical defect in additively manufactured (AM) parts. Such defects limit the properties and performance of AM parts, and therefore need to be characterized accurately. Current methods for characterization of defects and microstructure rely on classical stereological methods that extrapolate information from two dimensional images. The automation of serial sectioning provides an opportunity to precisely and accurately quantify porosity in three dimensions in materials. In this work, we analyzed the porosity of an additively manufactured Ti 6Al 2Sn 4Zr 2Mo sample using Robo-Met.3D "r"e"g"i"s"t"e"r"e"d, an automated serial sectioning system. Image processing for three dimensional reconstruction of the serial-sectioned two dimensional images was performed using open source image analysis software (Fiji/ImageJ, Dream.3D, Paraview). The results from this 3D serial sectioning analysis were then compared to classical 2D stereological methods (Saltykov stereological theory). We found that for this dataset, the classical 2D methods underestimated the porosity size and distributions of the larger pores; a critical attribute to fatigue behavior of the AM part. The results suggest that acquiring experimental data with equipment such as Robo-Met.3D "r"e"g"i"s"t"e"r"e"d to measure the number and size of particles such as pores in a volume irrespective of knowing their shape is a better choice.

Network configuration of global R&D networks

DEFF Research Database (Denmark)

Hansen, Zaza Nadja Lee; Srai, Jagjit Singh

2011-01-01

, network configuration of global R&D has tended to focus on strategic elements with limited attention given operational effectiveness, or to interfaces with downstream manufacturing operations. Within OM literature, the drivers of configuration of global networks within, engineering, production, supply...... to R&D networks emerged, e.g. product features were more prominent in R&D networks. Furthermore, the study has shown extensive interaction with other operations, including many downstream manufacturing operations. By extending the OM configuration concepts to the configuration of R&D networks......Companies are increasingly globalising their R&D activities, both within the firms and with external partners, with consequent implications for their interaction with manufacturing operations. Previous research in R&D networks has focused on coordination, governance and support elements. However...

Global-scale assessment and combination of SMAP with ASCAT (active) and AMSR2 (passive) soil moisture products

Science.gov (United States)

Kim, Hyunglok; Parinussa, Robert; Konings, Alexandra G.; Wagner, Wolfgang; Cosh, Michael H.; Lakshmi, Venkat; Zohaib, Muhammad; Choi, Minha

2018-01-01

Global-scale surface soil moisture (SSM) products retrieved from active and passive microwave remote sensing provide an effective method for monitoring near-real-time SSM content with nearly daily temporal resolution. In the present study, we first inter-compared global-scale error patterns and combined the Soil Moisture Active Passive (SMAP), Advanced Scatterometer (ASCAT), and Advanced Microwave Scanning Radiometer 2 (AMSR2) SSM products using a triple collocation (TC) analysis and the maximized Pearson correlation coefficient (R) method from April 2015 to December 2016. The Global Land Data Assimilation System (GLDAS) and global in situ observations were utilized to investigate and to compare the quality of satellite-based SSM products. The average R-values of SMAP, ASCAT, and AMSR2 were 0.74, 0.64, and 0.65 when they compared with in situ networks, respectively. The ubRMSD values were (0.0411, 0.0625, and 0.0708) m3 m- 3; and the bias values were (- 0.0460, 0.0010, and 0.0418) m3 m- 3 for SMAP, ASCAT, and AMSR2, respectively. The highest average R-values from SMAP against the in situ results are very encouraging; only SMAP showed higher R-values than GLDAS in several in situ networks with low ubRMSD (0.0438 m3 m- 3). Overall, SMAP showed a dry bias (- 0.0460 m3 m- 3) and AMSR2 had a wet bias (0.0418 m3 m- 3); while ASCAT showed the least bias (0.0010 m3 m- 3) among all the products. Each product was evaluated using TC metrics with respect to the different ranges of vegetation optical depth (VOD). Under vegetation scarce conditions (VOD 0.40) ASCAT showed comparatively better performance than did the other products. Using the maximized R method, SMAP, ASCAT, and AMSR2 products were combined one by one using the GLDAS dataset for reference SSM values. When the satellite products were combined, R-values of the combined products were improved or degraded depending on the VOD ranges produced, when compared with the results from the original products alone. The

Reviewing Manuscripts for Biomedical Journals

Science.gov (United States)

Garmel, Gus M

2010-01-01

Writing for publication is a complex task. For many professionals, producing a well-executed manuscript conveying one's research, ideas, or educational wisdom is challenging. Authors have varying emotions related to the process of writing for scientific publication. Although not studied, a relationship between an author's enjoyment of the writing process and the product's outcome is highly likely. As with any skill, practice generally results in improvements. Literature focused on preparing manuscripts for publication and the art of reviewing submissions exists. Most journals guard their reviewers' anonymity with respect to the manuscript review process. This is meant to protect them from direct or indirect author demands, which may occur during the review process or in the future. It is generally accepted that author identities are masked in the peer-review process. However, the concept of anonymity for reviewers has been debated recently; many editors consider it problematic that reviewers are not held accountable to the public for their decisions. The review process is often arduous and underappreciated, one reason why biomedical journals acknowledge editors and frequently recognize reviewers who donate their time and expertise in the name of science. This article describes essential elements of a submitted manuscript, with the hopes of improving scientific writing. It also discusses the review process within the biomedical literature, the importance of reviewers to the scientific process, responsibilities of reviewers, and qualities of a good review and reviewer. In addition, it includes useful insights to individuals who read and interpret the medical literature. PMID:20740129

The Effects of State R&D Tax Credits in Stimulating Private R&D Expenditure: A Cross-State Empirical Analysis

Science.gov (United States)

Wu, Yonghong

2005-01-01

This is a cross-state empirical study which examines the effects of state research and development (R&D) tax credits on private R&D expenditure in the states. Other explanatory variables include federal R&D subsidies, public services in higher education and R&D-targeted programs as well as other control variables. The statistical result shows that…

2003 RIA R AND D WORKSHOP.

Energy Technology Data Exchange (ETDEWEB)

OZAKI, S.ET AL.

2003-08-26

The 2003 RIA R&D Workshop was held on August 26-28, 2003 at the Four Points Sheraton Hotel in Bethesda, Maryland. This Workshop was chaired by Satoshi Ozaki of BNL and sponsored by the Nuclear Physics Division of DOE, with the help of Oak Ridge Institute for Science and Education (ORISE). The purpose of this workshop was to understand the present status of R&D efforts for RIA, to evaluate the needs for further R&D, and to identify opportunities for international collaborations. The workshop examined and documented the current pre-conceptual design for RIA, identifying areas where decisions on technical options remain. The status of the current RIA R&D program was documented, recognizing areas where efforts were needed in light of what had been learned. The ongoing and planned R&D activities for operating and planned rare-isotope facilities were presented, enabling the workshop to be a venue to develop coordinated R&D efforts of mutual benefit to U.S. and international efforts. The scientific program for the first day (August 26, 2003) consisted mostly of invited talks presented by major research groups involved in RIA and other RI beam facilities. The talks included those covering: Science of RIA and the RIA Facility Performance Requirements; The Reference RIA Facility Pre-CDR design that was used for the NSAC cost exercise (M. Harrison Sub-Panel) in January 2001; New or latest perspectives on the RIA design at ANL & MSU; and RI Beam facility plans and overview of the R&D activities at overseas laboratories. The second day (August 27, 2003) was devoted to contributed talks on continuing R&D, including that which had been supported by DOE RIA R&D funds. The third day (August 28, 2003) began with open panel discussions in the morning, including further input from participants. The panel members discussed the present status of the RIA planning and R&D needs in a closed session for the rest of the day, and then worked on report planning and writing. This Workshop

Initial mass function in R-associations CMaR1, Mon R1 and Mon R2 from radiodata

International Nuclear Information System (INIS)

Pyatunina, T.B.

1985-01-01

Results of search for compact radiosources in R-associations CMa R1 and Mon R1 carried out with the radiotelescope RATAN-600 at the 7.6-cm wavelength are given. The number of sources found in the association Mon R1 is approximately equal to the expected number of background extragalactic radiosources. In the association CMa R1 seven radiosources of small angular diameter with the flux greater than 30 mJy are found, two of which probably are background sources. A comparison of optical and radiodata on the association CMa R1 and previously published data on the association Mon R2 make it possible to estimate the initial mass function for associations under study: xi(M) infinity Msup(-2.7+-0.7) for stars with M approximately 10Msub(Sun)

The manuscript of Kartoteka (Card Index

Directory of Open Access Journals (Sweden)

Zbigniew Władysław Solski

2009-01-01

Full Text Available At the beginning of the 70s Tadeusz Różewicz presented the manuscript of Card Index to Professor Józef Kelera. It might have stayed a secret of friendship of the dramatist and the critic, however, Różewicz revealed the initials of his friend when in a commenatry to the play, he posed a question, whether there was a full stop after the last word in the manuscript or not? Posing this question, the author claimed the integrality of his masterpiece which was threatened by the widespread interpretations of Card Index as a play of a loose and dispersed structure. Appreciating the value of this question, I turned to Professor Kelera. This way I have had an access to the autograph of the play. In this manuscript has been preserved the play from before its final editing, which its author must surely have made during typing the text. Handwritten notes contain two unknown versions of the play with fragments which would not have been passed by the censors in the then Polish People’s Republic. In the reading of the manuscript the functions of the word and its graphic shape appeared of equal importance, so this version of Card Index can be recognised as a masterpiece of literature.

Ekundayo*1, E. O., Abbey2 S. D. and Okorie3,O.

African Journals Online (AJOL)

AFRICAN JOURNAL OF CLINICAL AND EXPERIMENTAL MICROBIOLOGY. ... Nigeria; 2 Department of Medical Laboratory Sciences, Faculty of Science, Rivers State University of Science .... recommend quality control of SSM as an essential.

Extended Special Sensor Microwave Imager (SSM/I) Temperature Data Record (TDR) in netCDF

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Special Sensor Microwave Imager (SSM/I) is a seven-channel linearly polarized passive microwave radiometer that operates at frequencies of 19.36 (vertically and...

Extended Special Sensor Microwave Imager (SSM/I) Sensor Data Record (SDR) in netCDF

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Special Sensor Microwave Imager (SSM/I) is a seven-channel linearly polarized passive microwave radiometer that operates at frequencies of 19.36 (vertically and...

R and D contract management systems in the USA (Attachment); Beikoku ni okeru R and D contract kanri system (tenpu shiryohen)

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-02-01

Presented herein is the attachment for 'R and D contract management systems in the USA'. The major contents include regulations governing the R and D contracts, procedures for the R and D contracts, financial procedures for the R and D contracts, procedures for the alternative R and D contracts, financial management of the R and D contracts, and activities for the management of the contract processes by electronic systems. (NEDO)

Manuscripts as Evidence for the use of Classics in Education, c. 800–1200: Estimating the Randomness of Survival

Directory of Open Access Journals (Sweden)

Jaakko Tahkokallio

2017-06-01

Full Text Available Are the surviving copies of schooltexts representative of what was popularly used in schools in the medieval period? In other words, was the survival of these manuscripts a random or selective process? To approach this question, this article presents a series of comparisons between the numbers of manuscripts of different schooltexts. It demonstrates that the most popular schooltexts all survive in very similar numbers from each century, and that the typical number of copies varies from one century to another. The easiest explanation for such a survival pattern is to assume that the texts were produced in equal numbers and passed through a relatively random filter of losses. The article seeks to test this intuitive explanation by using a simple probability mathematical experiment. In addition, the article analyses how the numbers of surviving manuscripts relate to entries in medieval book lists and medieval library catalogues. This examination supports the interpretation that the survival of schooltexts was a relatively random process. In addition, comparison between medieval book lists and extant manuscripts advocates caution in using the book lists as evidence for the popularity of texts in the medieval centuries. Even though the catalogues provide snapshots of specific historical situations, this paper concludes that the mass of extant books is more likely to give us a realistic picture of the contemporary popularity of texts.

Summary of findings of the R ampersand D committee

International Nuclear Information System (INIS)

Kenley, C.R.; Kokenge, B.R.

1996-01-01

In March 1995, the Department of Energy's (DOE) Nuclear Materials Stabilization Task Group (NMST) chartered a committee to formulate a research and development (R ampersand D) plan in response to Sub-recommendation (2) of Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1. The NMSTG was established as an organizational unit operating under the auspices of the DOE Office of the Environmental Management. As a result of its efforts, the Research Committee concluded that, in general, the technology needs for stabilizing 94-1 nuclear materials are being adequately met by existing or planned DOE programs. At the same time, the committee, in the form of recommendations, noted specific R ampersand D program areas that should be addressed by the NMSTG. These recommendations are documented in the R ampersand D plan and formulated based on: (1) existing open-quotes gapsclose quotes in DOE's R ampersand D stabilization program, (2) the relative maturity of various technologies, and (3) other important R ampersand D program issues that, in the judgement of the committee, should be addressed by the NMSTG. A systems engineering approach, derived form the aerospace industry, was applied to the various stabilization technologies to assess their relative maturity and availability for use in treating 94-1 nuclear materials

Comparison of the heat treatment response of wrought and SSM-HPDC alloy 6082

CSIR Research Space (South Africa)

Möller, H

2011-06-01

Full Text Available The natural and artificial aging responses of wrought and SSM-HPDC alloy 6082 are compared. It is shown that the heat treatment response of this Al-Mg-Si alloy is not influenced by differences in microstructures produced by different processing...

R and D contract management systems in the USA (Attachment); Beikoku ni okeru R and D contract kanri system (tenpu shiryohen)

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-02-01

Presented herein is the attachment for 'R and D contract management systems in the USA'. The major contents include regulations governing the R and D contracts, procedures for the R and D contracts, financial procedures for the R and D contracts, procedures for the alternative R and D contracts, financial management of the R and D contracts, and activities for the management of the contract processes by electronic systems. (NEDO)

Measurement of the hyperfine structure of the 4d2D3/2,5/2 levels and isotope shifts of the 4p2P3/2->4d2D3/2 and 4p2P3/2->4d2D5/2 transitions in gallium 69 and 71

International Nuclear Information System (INIS)

Rehse, Steven J.; Fairbank, William M.; Lee, Siu Au

2001-01-01

The hyperfine structure of the 4d 2 D 3/2,5/2 levels of 69,71 Ga is determined. The 4p 2 P 3/2 ->4d 2 D 3/2 (294.50-nm) and 4p 2 P 3/2 ->4d 2 D 5/2 (294.45-nm) transitions are studied by laser-induced fluorescence in an atomic Ga beam. The hyperfine A constant measured for the 4d 2 D 5/2 level is 77.3±0.9 MHz for 69 Ga and 97.9± 0.7 MHz for 71 Ga (3σ errors). The A constant measured for the 4d 2 D 3/2 level is -36.3±2.2 MHz for 69 Ga and -46.2±3.8 MHz for 71 Ga. These measurements correct sign errors in the previous determination of these constants. For 69 Ga the hyperfine B constants measured for the 4d 2 D 5/2 and the 4d 2 D 3/2 levels are 5.3±4.1 MHz and 4.6±4.2 MHz, respectively. The isotope shift is determined to be 114±8 MHz for the 4p 2 P 3/2 ->4d 2 D 3/2 transition and 115±7 MHz for the 4p 2 P 3/2 ->4d 2 D 5/2 transition. The lines of 71 Ga are shifted to the blue. This is in agreement with previous measurement. [copyright] 2001 Optical Society of America

Writing biomedical manuscripts part I: fundamentals and general rules.

Science.gov (United States)

Ohwovoriole, A E

2011-01-01

It is a professional obligation for health researchers to investigate and communicate their findings to the medical community. The writing of a publishable scientific manuscript can be a daunting task for the beginner and to even some established researchers. Many manuscripts fail to get off the ground and/or are rejected. The writing task can be made easier and the quality improved by using and following simple rules and leads that apply to general scientific writing .The manuscript should follow a standard structure:(e.g. (Abstract) plus Introduction, Methods, Results, and Discussion/Conclusion, the IMRAD model. The authors must also follow well established fundamentals of good communication in science and be systematic in approach. The manuscript must move from what is currently known to what was unknown that was investigated using a hypothesis, research question or problem statement. Each section has its own style of structure and language of presentation. The beginning of writing a good manuscript is to do a good study design and to pay attention to details at every stage. Many manuscripts are rejected because of errors that can be avoided if the authors follow simple guidelines and rules. One good way to avoid potential disappointment in manuscript writing is to follow the established general rules along with those of the journal in which the paper is to be published. An important injunction is to make the writing precise, clear, parsimonious, and comprehensible to the intended audience. The purpose of this article is to arm and encourage potential biomedical authors with tools and rules that will enable them to write contemporary manuscripts, which can stand the rigorous peer review process. The expectations of standard journals, and common pitfalls the major elements of a manuscript are covered.

Strategic management of government-sponsored R&D portfolios

OpenAIRE

Barry Bozeman; Juan Rogers

2001-01-01

Although strategic management of R&D portfolios is common practice in private sector R&D, government R&D management tends to be more discrete and ad hoc, focusing on generating maximum output from individual projects. Often, there is no clear notion of the desired public sector output. Whereas private sector R&D evaluation is generally straightforward, with the function of R&D being measured in terms of a company's internal return on investment, the benefits of public-sponsored R&D tend to be...

Timbuktu Rare Manuscripts Project: Promoting African partnerships ...

African Journals Online (AJOL)

This article describes the Timbuktu Rare Manuscripts Project. The project is concerned with providing assistance to Mali in the conservation and preservation of the rich trove of manuscripts to be found in and around the immediate environs of Timbuktu. The project is a result of a bilateral agreement concluded between the ...

2-D and 3-D CFD Investigation of NREL S826 Airfoil at Low Reynolds Numbers

International Nuclear Information System (INIS)

Cakmakcioglu, S C; Sert, I O; Tugluk, O; Sezer-Uzol, N

2014-01-01

In this study CFD investigation of flow over the NREL S826 airfoil is performed. NREL S826 airfoil was designed for HAWTs of 10-15 meter diameters. However, it is used in the NTNU wind turbine rotor model and low Reynolds number flow characteristics become important in the validations with the test cases of this rotor model. The airfoil CFD simulations are carried out in 2-D and 3-D computational domains. The k-rn SST turbulence model with Langtry-Menter (γ-Re θ ) transition prediction model for turbulence closure is used in the calculations. The Delayed DES is also performed in the stall region for comparisons. The results are compared with the available METUWIND experimental data, and are shown to be in fair agreement. It is observed that 3-D CFD analysis provides increased accuracy at increased computational cost

R and D limited partnerships (possible applications in advanced communications satellite technology experiment program)

Science.gov (United States)

1985-01-01

Typical R&D limited partnership arrangements, advantages and disadvantages of R&D limited partnership (RDLPs) and antitrust and tax implications are described. A number of typical forms of RDLPs are described that may be applicable for use in stimulating R&D and experimental programs using the advanced communications technology satellite. The ultimate goal is to increase the rate of market penetration of goods and/or services based upon advanced satellite communications technology. The conditions necessary for these RDLP forms to be advantageous are outlined.

CAT-ASVAB Technical Bulletin Number 1

Science.gov (United States)

2006-03-01

CAT -ASVAB Technical Bulletin #1 Personnel Testing Division Defense Manpower Data Center March 2006 Report...2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE CAT -ASVAB Technical Bulletin #1 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...Hetter, R. D. "Psychometric Procedures for Administering CAT -ASVAB" (pp. 131-140) Chapter 4 Hetter, R. D., & Sympson J. B. "Item Exposure

High-resolution structural and functional assessments of cerebral microvasculature using 3D Gas ΔR2*-mMRA.

Science.gov (United States)

Huang, Chien-Hsiang; Chen, Chiao-Chi V; Siow, Tiing-Yee; Hsu, Sheng-Hsiou S; Hsu, Yi-Hua; Jaw, Fu-Shan; Chang, Chen

2013-01-01

The ability to evaluate the cerebral microvascular structure and function is crucial for investigating pathological processes in brain disorders. Previous angiographic methods based on blood oxygen level-dependent (BOLD) contrast offer appropriate visualization of the cerebral vasculature, but these methods remain to be optimized in order to extract more comprehensive information. This study aimed to integrate the advantages of BOLD MRI in both structural and functional vascular assessments. The BOLD contrast was manipulated by a carbogen challenge, and signal changes in gradient-echo images were computed to generate ΔR2* maps. Simultaneously, a functional index representing the regional cerebral blood volume was derived by normalizing the ΔR2* values of a given region to those of vein-filled voxels of the sinus. This method is named 3D gas ΔR2*-mMRA (microscopic MRA). The advantages of using 3D gas ΔR2*-mMRA to observe the microvasculature include the ability to distinguish air-tissue interfaces, a high vessel-to-tissue contrast, and not being affected by damage to the blood-brain barrier. A stroke model was used to demonstrate the ability of 3D gas ΔR2*-mMRA to provide information about poststroke revascularization at 3 days after reperfusion. However, this technique has some limitations that cannot be overcome and hence should be considered when it is applied, such as magnifying vessel sizes and predominantly revealing venous vessels.

An empirical analysis of overlap publication in Chinese language and English research manuscripts.

Directory of Open Access Journals (Sweden)

Joseph D Tucker

Full Text Available BACKGROUND: There are a number of sound justifications for publishing nearly identical information in Chinese and English medical journals, assuming several conditions are met. Although overlap publication is perceived as undesirable and ethically questionable in Europe and North America, it may serve an important function in some regions where English is not the native tongue. There is no empirical data on the nature and degree of overlap publication in English and Chinese language journals. METHODS/PRINCIPAL FINDINGS: A random sample of 100 English manuscripts from Chinese institutions was selected from PubMed. Key words and institutions were searched in the China National Knowledge Infrastructure, a comprehensive Chinese language research database. Unacknowledged overlap was a priori defined according to International Committee of Medical Journal Editor (ICMJE guidelines following examination by two individuals. 19% (95% CI 11-27 of English manuscripts from Chinese institutions were found to have substantial overlap with Chinese published work based on full text examination. None of the manuscripts met all of the criteria established by the ICMJE for an acknowledged overlap publication. Individual-level, journal-level, and institutional factors seem to influence overlap publication. Manuscripts associated with an institution outside of China and with more than one institution were significantly less likely to have substantial overlap (p<0.05. CONCLUSIONS/SIGNIFICANCE: Overlap publication was common in this context, but instances of standard ICMJE notations to acknowledge this practice were rare. This research did not cite the identified overlap manuscripts with the hope that these empirical data will inform journal policy changes and structural initiatives to promote clearer policies and manuscripts.

Evaluating firms' R&D performance using best worst method.

Science.gov (United States)

Salimi, Negin; Rezaei, Jafar

2018-02-01

Since research and development (R&D) is the most critical determinant of the productivity, growth and competitive advantage of firms, measuring R&D performance has become the core of attention of R&D managers, and an extensive body of literature has examined and identified different R&D measurements and determinants of R&D performance. However, measuring R&D performance and assigning the same level of importance to different R&D measures, which is the common approach in existing studies, can oversimplify the R&D measuring process, which may result in misinterpretation of the performance and consequently fallacy R&D strategies. The aim of this study is to measure R&D performance taking into account the different levels of importance of R&D measures, using a multi-criteria decision-making method called Best Worst Method (BWM) to identify the weights (importance) of R&D measures and measure the R&D performance of 50 high-tech SMEs in the Netherlands using the data gathered in a survey among SMEs and from R&D experts. The results show how assigning different weights to different R&D measures (in contrast to simple mean) results in a different ranking of the firms and allow R&D managers to formulate more effective strategies to improve their firm's R&D performance by applying knowledge regarding the importance of different R&D measures. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

‘Communicating Manuscripts’: Third Conference of LIBER's Manuscript Librarians Group, Berlin, 28-30 November 2007

Directory of Open Access Journals (Sweden)

Jutta Weber

2008-03-01

Full Text Available LIBER's Manuscript Librarians Group held its third conference, entitled 'Communicating Manuscripts' in Berlin from 28-30 November 2007. More than 70 participants from all over Europe came to discuss their experiences and opinions concerning manuscripts (ranging from medieval codices to modern papers and letter collections — in response to a series of papers delivered by a number of specialists from European research libraries and archival institutions. For the Staatsbibliothek it was a pleasure to welcome them and to make the days in Berlin comfortable and successful.

2003 RIA R AND D WORKSHOP

International Nuclear Information System (INIS)

OZAKI, S.

2003-01-01

The 2003 RIA R and D Workshop was held on August 26-28, 2003 at the Four Points Sheraton Hotel in Bethesda, Maryland. This Workshop was chaired by Satoshi Ozaki of BNL and sponsored by the Nuclear Physics Division of DOE, with the help of Oak Ridge Institute for Science and Education (ORISE). The purpose of this workshop was to understand the present status of R and D efforts for RIA, to evaluate the needs for further R and D, and to identify opportunities for international collaborations. The workshop examined and documented the current pre-conceptual design for RIA, identifying areas where decisions on technical options remain. The status of the current RIA R and D program was documented, recognizing areas where efforts were needed in light of what had been learned. The ongoing and planned R and D activities for operating and planned rare-isotope facilities were presented, enabling the workshop to be a venue to develop coordinated R and D efforts of mutual benefit to U.S. and international efforts. The scientific program for the first day (August 26, 2003) consisted mostly of invited talks presented by major research groups involved in RIA and other RI beam facilities. The talks included those covering: Science of RIA and the RIA Facility Performance Requirements; The Reference RIA Facility Pre-CDR design that was used for the NSAC cost exercise (M. Harrison Sub-Panel) in January 2001; New or latest perspectives on the RIA design at ANL and MSU; and RI Beam facility plans and overview of the R and D activities at overseas laboratories. The second day (August 27, 2003) was devoted to contributed talks on continuing R and D, including that which had been supported by DOE RIA R and D funds. The third day (August 28, 2003) began with open panel discussions in the morning, including further input from participants. The panel members discussed the present status of the RIA planning and R and D needs in a closed session for the rest of the day, and then worked on report

From 3 d duality to 2 d duality

Science.gov (United States)

Aharony, Ofer; Razamat, Shlomo S.; Willett, Brian

2017-11-01

In this paper we discuss 3 d N = 2 supersymmetric gauge theories and their IR dualities when they are compactified on a circle of radius r, and when we take the 2 d limit in which r → 0. The 2 d limit depends on how the mass parameters are scaled as r → 0, and often vacua become infinitely distant in the 2 d limit, leading to a direct sum of different 2 d theories. For generic mass parameters, when we take the same limit on both sides of a duality, we obtain 2 d dualities (between gauge theories and/or Landau-Ginzburg theories) that pass all the usual tests. However, when there are non-compact branches the discussion is subtle because the metric on the moduli space, which is not controlled by supersymmetry, plays an important role in the low-energy dynamics after compactification. Generally speaking, for IR dualities of gauge theories, we conjecture that dualities involving non-compact Higgs branches survive. On the other hand when there is a non-compact Coulomb branch on at least one side of the duality, the duality fails already when the 3 d theories are compactified on a circle. Using the valid reductions we reproduce many known 2 d IR dualities, giving further evidence for their validity, and we also find new 2 d dualities.

Strategic R&D transactions in personalized drug development.

Science.gov (United States)

Makino, Tomohiro; Lim, Yeongjoo; Kodama, Kota

2018-03-21

Although external collaboration capability influences the development of personalized medicine, key transactions in the pharmaceutical industry have not been addressed. To explore specific trends in interorganizational transactions and key players, we longitudinally surveyed strategic transactions, comparing them with other advanced medical developments, such as antibody therapy, as controls. We found that the financing deals of start-ups have surged over the past decade, accelerating intellectual property (IP) creation. Our correlation and regression analyses identified determinants of financing deals among alliance deals, acquisition deals, patents, research and development (R&D) licenses, market licenses, and scientific papers. They showed that patents positively correlated with transactions, and that the number of R&D licenses significantly predicted financing deals. This indicates, for the first time, that start-ups and investors lead progress in personalized medicine. Copyright © 2018 Elsevier Ltd. All rights reserved.

The Impact of Organizational Knowledge Integrators on Cooperative R&D Projects

DEFF Research Database (Denmark)

Bulathsinhala, Nadika

2014-01-01

This paper addresses the fact that R&D projects that incorporate external knowledge sources not only depend on the number of sources, but also on integrating the right source. An organizational knowledge integrator has a natural interest due to its position in the value chain and the technology...... phase to pull the knowledge from earlier phases of development closer towards commercialization. The aim of the paper is to examine if organizational knowledge integrators in R&D projects have a positive impact on innovative performance compared to projects that do not involve a knowledge integrator...

Manuscript of Marc Popovski about Tolstoyan movement

Directory of Open Access Journals (Sweden)

Kolupaev Vladimir Evgen'yevich

2014-07-01

Full Text Available Publication of archival documents, i.e. manuscripts of Marc Popovski, a famous writer, journalist, human rights activist, dissident, and vice president of the organization “Writers in Exile” American branch of PEN. The manuscript is dedicated to the fate of Russian religious philosophical sect, Tolstoyan movement, in the Soviet period, its repressions and its eventual destruction.

Path covering number and L(2,1)-labeling number of graphs

OpenAIRE

Lu, Changhong; Zhou, Qing

2012-01-01

A {\\it path covering} of a graph $G$ is a set of vertex disjoint paths of $G$ containing all the vertices of $G$. The {\\it path covering number} of $G$, denoted by $P(G)$, is the minimum number of paths in a path covering of $G$. An {\\sl $k$-L(2,1)-labeling} of a graph $G$ is a mapping $f$ from $V(G)$ to the set ${0,1,...,k}$ such that $|f(u)-f(v)|\\ge 2$ if $d_G(u,v)=1$ and $|f(u)-f(v)|\\ge 1$ if $d_G(u,v)=2$. The {\\sl L(2,1)-labeling number $\\lambda (G)$} of $G$ is the smallest number $k$ suc...

Variable-Base Budgeting for R&D

OpenAIRE

Robert W. Blanning

1981-01-01

An issue of theoretical and practical importance to R&D managers is the proper allocation of an organization's resources between the periodic selection and budgeting of R&D projects and the implementation of these projects. One possibility is to consider previous allocations as an established base and to restrict the attention of R&D managers to an examination of any subsequent deviations from the base. The advantage of this strategy, often called incremental budgeting, is that it focuses man...

Alpha1 and D2 receptors in a place avoidance task in rats: evidence for a synergism

Czech Academy of Sciences Publication Activity Database

Stuchlík, Aleš; Petrásek, Tomáš; Valeš, Karel

2008-01-01

Roč. 104, Suppl.2 (2008), s. 1135-1135 ISSN 1212-0383. [World congress of psychiatry /14./. 20.09.2008-25.09.2008, Prague] R&D Projects: GA ČR(CZ) GA309/07/0341; GA MZd(CZ) NR9178; GA MŠk(CZ) LC554; GA MŠk(CZ) 1M0517 Institutional research plan: CEZ:AV0Z50110509 Keywords : cpo1 * avoidance * memory * rat Subject RIV: FH - Neurology

Spatial and temporal multiyear sea ice distributions in the Arctic: A neural network analysis of SSM/I data, 1988-2001

Science.gov (United States)

Belchansky, G.I.; Douglas, D.C.; Alpatsky, I.V.; Platonov, Nikita G.

2004-01-01

the previous 8-year decline in total area, but it was followed by an accelerated and compensatory decline during the subsequent 4 years. Seventy-five percent of the interannual variation in January multiyear sea ice area was explained by linear regression on two atmospheric parameters: the previous inter's (JFM) Arctic Oscillation index as a proxy to melt duration and the previous year's average sea level pressure gradient across the Fram Strait as a proxy to annual ice export. Consecutive year changes (1994-2001) in January multiyear ice volume were significantly correlated with duration of the intervening melt season (R2 = 0.73, -80.0 km3/d-1), emphasizing a large thermodynamic influence on the Arctic's mass sea ice balance during summers with anomalous melt durations.

Are there Diminishing Returns to R&D?

DEFF Research Database (Denmark)

Madsen, Jakob B.

Semi-endogenous models and, to some extent, also Schumpeterian models are based on the assumption of diminishing returns to R&D. This paper shows that the null hypothesis of constant returns to R&D cannot be rejected for the OECD countries......Semi-endogenous models and, to some extent, also Schumpeterian models are based on the assumption of diminishing returns to R&D. This paper shows that the null hypothesis of constant returns to R&D cannot be rejected for the OECD countries...

PET studie4s of dopamine D2 receptors in subclinical and clinical hemi-parkinsonism monkeys with 11C-Raclopride

International Nuclear Information System (INIS)

Bian Yanzhu; Zhang Jinming; Tian Jiahe; Yao Shulin; Liu Huaijun

2005-01-01

Objective: To explore the characters of dopamine D 2 receptors (D 2 R) of subclinical and clinical hemi-parkinsonism monkeys. Methods: Four subclinical hemi-pakinsonism monkeys were developed by given one dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropridine (MPTP) 0.3 mg/kg through fight internal carotid artery. Two clinical hemi-pakinsonism monkeys were developed by given 2 doses of MPTP 0.7 mg/kg through right internal carotid artery and the 2 doses were 4 weeks apart. 11 C-Raclopride was synthesized as an imaging agent of D 2 R. Four normal, 4 subclinical and 2 clinical hemi-parkinsonism monkeys underwent 11 C-Raclopride D 2 R PET, and the striatum D 2 R function was evaluated by region of interest (ROI) technique. Results: Symmetric striatal uptake was observed in normal and subclinical hemi-parkinsonism monkeys, the radioactivity ratios of striatum/cerebellum were 5.00±0.74, 5.04±0.72, respectively (t=1.016, P>0.05). There was a significant increase in 11 C-Raclopride binding in the fight striatum (lesioned side) of the two clinical hemi-pakinsonism monkeys; up-regulation of leisoned side striatum D 2 R was found; compared to the left sides, the radioactivity ratios of striatum cerebellum of right sides (lesioned sides) of the two monkeys were increased by 19.69%, 22.68%, respectively. Conclusions: 11 C-Raclopride was successfully synthesized as a D 2 R PET agent. The striatum D 2 R function was of no evident changes in subclinical hemi-parkinsonism monkeys. The striatum 132 R function was upregulated in lesioned side in clinical hemi-parkinsonism monkeys. (authors)

Sequencing R&D Decisions in a Two-Period Duopoly with Spillovers

DEFF Research Database (Denmark)

Amir, Madjid; Amir, Rabah; Jin, Jim

2000-01-01

We compare simultaneous versus sequential moves in R&D decisions within an asymmetric R&D/Cournot model with linear demand (for differentiated products), general R&D costs, and spillovers. Simultaneous play and sequential play (with and without a specified leader) can emerge as appropriate...... formulations, depending on the ratios of spillover rate over demand cross-slope, but not on R&D efficiency. When at least one ratio is above 1/2, a sequential solution mitigates competition and leads to higher profits for each firm, and to higher social welfare. When uniquely specified, the stronger firm...

Acceptance rate and reasons for rejection of manuscripts submitted to Veterinary Radiology & Ultrasound during 2012.

Science.gov (United States)

Lamb, Christopher R; Mai, Wilfried

2015-01-01

Better understanding of the reasons why manuscripts are rejected, and recognition of the most frequent manuscript flaws identified by reviewers, should help submitting authors to avoid these pitfalls. Of 219 manuscripts submitted to Veterinary Radiology & Ultrasound in 2012, none (0%) was accepted without revision, four (2%) were withdrawn by the authors, 99 (45%) were accepted after revision, and 116 (53%) were rejected. All manuscripts for which minor revision was requested, and 73/86 (85%) manuscripts for which major revision was requested, were ultimately accepted. Acceptance rate was greater for retrospective studies and for manuscripts submitted from countries in which English was the primary language. The prevalences of flaws in manuscripts were poor writing (62%), deficiencies in data (60%), logical or methodological errors (28%), content not suitable for Veterinary Radiology & Ultrasound (26%), and lack of new or useful knowledge (25%). Likelihood of manuscript rejection was greater for lack of new or useful knowledge and content not suitable than for other manuscript flaws. The lower acceptance rate for manuscripts from countries in which English was not the primary language was associated with content not suitable and not poor writing. Submitting authors are encouraged to do more to recognize and address manuscript flaws before submission, for example by internal review. Specifically, submitting authors should express clearly the potential added value of their study in the introduction section of their manuscript, describe completely their methods and results, and consult the Editor-in-Chief if they are uncertain whether their subject matter would be suitable for the journal. © 2014 American College of Veterinary Radiology.

Agricultural R&D, technology and productivity.

Science.gov (United States)

Piesse, J; Thirtle, C

2010-09-27

The relationships between basic and applied agricultural R&D, developed and developing country R&D and between R&D, extension, technology and productivity growth are outlined. The declining growth rates of public R&D expenditures are related to output growth and crop yields, where growth rates have also fallen, especially in the developed countries. However, growth in output value per hectare has not declined in the developing countries and labour productivity growth has increased except in the EU. Total factor productivity has generally increased, however it is measured. The public sector share of R&D expenditures has fallen and there has been rapid concentration in the private sector, where six multinationals now dominate. These companies are accumulating intellectual property to an extent that the public and international institutions are disadvantaged. This represents a threat to the global commons in agricultural technology on which the green revolution has depended. Estimates of the increased R&D expenditures needed to feed 9 billion people by 2050 and how these should be targeted, especially by the Consultative Group on International Agricultural Research (CGIAR), show that the amounts are feasible and that targeting sub-Saharan Africa (SSA) and South Asia can best increase output growth and reduce poverty. Lack of income growth in SSA is seen as the most insoluble problem.

Manuscript Évora, Biblioteca Pública, Cód. CLI/1-3: Its Origin and Contents, and the Stemmata of Late-Sixteenth- and Early-Seventeenth- Century Portuguese Sources

Directory of Open Access Journals (Sweden)

d’Alvarenga, João Pedro

2011-12-01

Full Text Available Manuscript Évora, Biblioteca Pública, Cód. CLI/1-3 is a small volume made up of two originally independent manuscripts datable respectively to c.1615 and c.1575, which were bound together sometime in the seventeenth century. The second part of the volume contains what is possibly the oldest, most persistent and widely-circulated of Holy Week series of responsories in extant late-sixteenth- and seventeenth-century Portuguese sources of polyphony. The first part is dominated by the works of Manuel Mendes, a composer whose considerable reputation rested especially on his abilities as a teacher, but whose works are among the most widespread pieces in Portuguese and American colonial manuscripts in the years around 1600. In this paper I will determine the origin of Évora Cód. CLI/1-3 by following the steps of Mendes’s career, and establish the relationship between this source and several other important manuscripts as to the transmission of two exemplary pieces through the study of variant readings and the rates of agreement of the sources in the points of variation, proposing a general stemmata for pieces in late-sixteenth and earlyseventeenth- century Portuguese sources of polyphony.

El Cód. CLI/1-3 de la Biblioteca Pública de Évora es un pequeño volumen compuesto por dos manuscritos originalmente independientes fechados hacia 1615 y 1575, respectivamente, los cuales fueron encuadernados juntos en algún momento del siglo XVII. La segunda parte del volumen contiene una serie de responsorios de Semana Santa, posiblemente la más antigua, duradera y de mayor circulación de entre las fuentes portuguesas de polifonía de finales del siglo XVI y del siglo XVII conservadas. En la primera parte sobresalen las obras de Manuel Mendes, un compositor cuya considerable reputación se debe sobre todo a sus habilidades como maestro, pero cuyas obras se encuentran entre las piezas más difundidas en los manuscritos portugueses y

Weak contrast PP wave displacement R/T coefficients in weakly anisotropic elastic media

Czech Academy of Sciences Publication Activity Database

Pšenčík, Ivan; Vavryčuk, Václav

1998-01-01

Roč. 151, 2/4 (1998), s. 699-718 ISSN 0033-4553. [International workshop on geodynamics of the lithosphere and the Earth's mantle, 08.07.1996-13.07.1996] R&D Projects: GA ČR GA205/96/0968 Grant - others:INCO-Copernicus(XE) IC15 CT96 200 Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 0.612, year: 1998

EU-US differences in the size of R&D intensive firms : Do they explain the overall R&D intensity gap?

NARCIS (Netherlands)

Ortega Argiles, Raquel; Brandsma, Andries

The average firm size of the top R&D investors among US-based companies is smaller than that of the EU-based firms. Does this help to explain why the US has a greater R&D intensity, or is the greater firm size in the EU, just as its lower R&D intensity, determined by the sectors in which the top R&D

Lessons learned from Ebola Vaccine R&D during a public health emergency.

Science.gov (United States)

Kieny, Marie-Paule

2018-02-16

In spite of a complete lack of Research and Development (R&D) preparedness, the 2013-2016 West-Africa Ebola experience demonstrated that it is possible to compress R&D timelines to less than a single year, from a more usual decade or longer. This is mostly to be credited to an unprecedented collaborative effort building on the availability of a small number of candidate diagnostic tests, drugs and vaccines that could be moved rapidly into the clinical phase evaluation. The World Health Organization (WHO) led international consultations and activities - including the organization of a successful Ebola vaccine efficacy trial in Guinea - as a contribution to the unprecedented global efforts to control the Ebola epidemic. Since 2015, WHO expert teams and partners are implementing a novel R&D model for emerging infectious pathogens which are the most likely to cause severe outbreaks in the future, and for which no or only few medical countermeasures are available: the WHO R&D Blueprint. The objective for the Blueprint is the fostering of a R&D environment which is prepared for quickly and effectively responding to outbreaks due to emerging infectious disease.

Optimal R&D Investments of the Firm

NARCIS (Netherlands)

Kort, P.M.

1996-01-01

This paper examines irreversible decisions on innovative activities where it takes time to complete an R&D project. The totala mountof R&D investments that the firm needs to undertake in order to obtain the breakthrough in the innovation process is uncertain. R&D investments are limited by the

Towards the implementation of a system for manuscript editor certification

Directory of Open Access Journals (Sweden)

Hyun Jung Yi

2016-02-01

Full Text Available Style and format are important criteria for evaluating a journal and indexing it in major databases. In Korean science, technology, and medical journals, interest in manuscript editing has increased over the past seven to eight years, and the responsibilities of manuscript editors have expanded as well. However, since no clear standards for the roles and qualifications for manuscript editors are yet available, a formal certification system is needed to establish appropriate standards and to provide professional training. To identify ways of developing a manuscript editor certification program in Korea, this study investigated similar certification programs in and outside the country and surveyed 195 Korean editors, manuscript editors, publishers, and medical librarians. The survey revealed that manuscript editors were necessary (mean score of 4.38 on a five-point Likert scale, with a score of 5 indicating strong agreement, and that their main contributions were efficiently managing the editorial board, improving the accuracy of references, and accelerating the editing process. The respondents were also positive about the possibility of implementing a manuscript editor certification; 45.1% showed interest in becoming certified, and 47.1% reported interest in hiring a certified manuscript editor. Regarding the system for issuing certification, respondents favored a professional training course (53.1%, validation of work experience (27.1%, or an examination (16.8%. This study concludes that it is essential to establish a formal certification program to train manuscript editors properly, and an examination system is the most efficient and suitable method for managing the certification process.

2D/2D nano-hybrids of γ-MnO{sub 2} on reduced graphene oxide for catalytic ozonation and coupling peroxymonosulfate activation

Energy Technology Data Exchange (ETDEWEB)

Wang, Yuxian [National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Beijing Engineering Research Center of Process Pollution Control, Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); Department of Chemical Engineering, Curtin University, GPO Box U1987, Perth, WA 6845 (Australia); Xie, Yongbing, E-mail: ybxie@ipe.ac.cn [National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Beijing Engineering Research Center of Process Pollution Control, Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); Sun, Hongqi [Department of Chemical Engineering, Curtin University, GPO Box U1987, Perth, WA 6845 (Australia); Xiao, Jiadong; Cao, Hongbin [National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Beijing Engineering Research Center of Process Pollution Control, Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); Wang, Shaobin, E-mail: shaobin.wang@curtin.edu.au [Department of Chemical Engineering, Curtin University, GPO Box U1987, Perth, WA 6845 (Australia)

2016-01-15

Highlights: • 2D γ-MnO{sub 2}/2D rGO hybrids (MnO{sub 2}/rGO) via a facile hydrothermal route were prepared. • MnO{sub 2}/rGO exhibits high activity in catalytic ozonation of 4-nitrophenol. • ·O{sub 2}{sup ̄} and {sup 1}O{sub 2} are the major radicals for 4-nitrophenol degradation and mineralization. • A synergistic effect of ozonation and peroxymonosulfate oxidation was evaluated. - Abstract: Two-dimensional reduced graphene oxide (2D rGO) was employed as both a shape-directing medium and support to fabricate 2D γ-MnO{sub 2}/2D rGO nano-hybrids (MnO{sub 2}/rGO) via a facile hydrothermal route. For the first time, the 2D/2D hybrid materials were used for catalytic ozonation of 4-nitrophenol. The catalytic efficiency of MnO{sub 2}/rGO was much higher than either MnO{sub 2} or rGO only, and rGO was suggested to play the role for promoting electron transfers. Quenching tests using tert-butanol, p-benzoquinone, and sodium azide suggested that the major radicals responsible for 4-nitrophenol degradation and mineralization are O{sub 2}{sup ̄} and {sup 1}O{sub 2}, but not ·OH. Reusability tests demonstrated a high stability of the materials in catalytic ozonation with minor Mn leaching below 0.5 ppm. Degradation mechanism, reaction kinetics, reusability and a synergistic effect between catalytic ozonation and coupling peroxymonosulfate (PMS) activation were also discussed.

Falling R and D but stable investments by oil companies, why? A study on R and D and investment in fixed assets in the oil industry

International Nuclear Information System (INIS)

Creusen, H.; Minne, B.

2000-04-01

In the last decade the world-wide research expenditures of the major oil companies have dropped. This is remarkable since their investments in fixed assets remained stable. This study reveals that the level of fixed investments particularly depend on their financial strength, while R and D mainly relates to competitors' research and common expectations. The decline in R and D is initiated by common expectations. In the mature oil industry, companies foresee diminishing research potential within the current technology. This is also confirmed by the declining number of patent applications. The high risks of research on renewable energy may lead to wait and see behaviour instead of new research initiatives. Actually, oil companies have hardly applied for patents on renewable energy. The R and D decline is intensified by a dwindling R and D-race, which is due to a large overlap in research topics. The companies protect their research results because they largely compete on their unique technologies which embody their research results. The research overlap appears from patents: the oil companies apply for patents in exactly the same patent classes. 19 refs

Modelling and simulation SSM: latest state of the art technology

CSIR Research Space (South Africa)

Jahajeeah, N

2005-10-01

Full Text Available as one phase ? One Phase model ?Wider volume solid fraction 0 – 1 ? Implementation in Power Law Cut-Off Model (PLCO) of Procast Supporting the Manufacturing and Materials Industry in its quest for global competitiveness Assumptions of the PLCO Model... and Materials Industry in its quest for global competitiveness Modelling and Simulation SSM Latest state of the art technology N Jahajeeah Supporting the Manufacturing and Materials Industry in its quest for global competitiveness BEHAVIOUR OF THIXOTROPIC...

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Energy Technology Data Exchange (ETDEWEB)

Chien, Ellen Y.T.; Liu, Wei; Zhao, Qiang; Katritch, Vsevolod; Han, Gye Won; Hanson, Michael A.; Shi, Lei; Newman, Amy Hauck; Javitch, Jonathan A.; Cherezov, Vadim; Stevens, Raymond C. (Cornell); (Scripps); (NIDA); (Columbia); (UCSD); (Receptos)

2010-11-30

Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the ligand binding pocket and extracellular loops. On the intracellular side of the receptor, a locked conformation of the ionic lock and two distinctly different conformations of intracellular loop 2 are observed. Docking of R-22, a D3R-selective antagonist, reveals an extracellular extension of the eticlopride binding site that comprises a second binding pocket for the aryl amide of R-22, which differs between the highly homologous D2R and D3R. This difference provides direction to the design of D3R-selective agents for treating drug abuse and other neuropsychiatric indications.

Multinational Exploration of Acquired R&D Activities

DEFF Research Database (Denmark)

Gammelgaard, Jens

2004-01-01

R&D. This paper establishes the connection between amultinational corporation that follows a capability-motivated acquisition strategy and theR&D role new subsidiaries should play in order for the acquired resources to be utilizedcorporation-wide. Statistical findings reveal the need to follow......This paper presents the results of a survey of 54 Danish multinational corporations that haveacquired activities abroad. The role of the acquired R&D units was the focus of the survey,particularly with respect to the schism between basic and applied R&D, and the schismbetween autonomous and network...

R&D and Price Elasticity of Demand

DEFF Research Database (Denmark)

Lucke, D.; Schröder, Philipp; D., Schumacher,

2004-01-01

This paper explores the relationship between the price elasticity of demand and the R&D intensity of the product. We introduce the concept of R&D intensity into a standard Dixit-Stiglitz/Krugman-type setting. R&D activity is treated as a fixed cost of production. Within this framework, sectors...... with a higher R&D intensity show a lower price elasticity of demand. This proposition is confirmed by an empirical investigation of export demand for manufactured goods from major industrialised countries. Consequently, real exchange rate changes have an impact on the commodity structure of exports....

Utility of DMSP-SSM/I for integrated water vapour over the Indian seas

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging Solutions)

Recent algorithms for Special Sensor Microwave/Imager (DMSP-SSM/I) satellite data are used for estimating integrated water vapour over the Indian seas. Integrated water vapour obtained from these algorithms is compared with that derived from radiosonde observations at Minicoy and Port. Blair islands. Algorithm-3 of ...

Investigating investment in biopharmaceutical R&D

Science.gov (United States)

Carter, Percy H.; Berndt, Ernst R.; DiMasi, Joseph A.; Trusheim, Mark

2016-01-01

Recent studies have highlighted a reduction in projected financial returns associated with biopharmaceutical R&D, owing to decreased productivity, increases in costs and flattening revenue per new drug, prompting calls for dramatic revisions to R&D models. On the basis of previous financial modelling, the simplest hypothesis would be that new investment in such R&D should be minimal and focused on biologics in preference to small molecules, as the internal rate of return on investment for biologics projects has been reported to be higher. PMID:27616295

Knowledge licensing in a model of R&D-driven endogenous growth

Czech Academy of Sciences Publication Activity Database

Jerbashian, Vahagn

2016-01-01

Roč. 16, č. 2 (2016), s. 555-579 ISSN 1935-1690 R&D Projects: GA ČR(CZ) GBP402/12/G097 Institutional support: PRVOUK-P23 Keywords : endogenous growth * in-house R&D * intellectual property regulation Subject RIV: AH - Economics Impact factor: 0.043, year: 2016

Comparison of CT numbers between cone-beam CT and multi-detector CT

International Nuclear Information System (INIS)

Kim, Dong Soo; Han, Won Jeong; Kim, Eun Kyung

2010-01-01

To compare the CT numbers on 3 cone-beam CT (CBCT) images with those on multi-detector CT (MDCT) image using CT phantom and to develop linear regressive equations using CT numbers to material density for all the CT scanner each. Mini CT phantom comprised of five 1 inch thick cylindrical models with 1.125 inches diameter of materials with different densities (polyethylene, polystyrene, plastic water, nylon and acrylic) was used. It was scanned in 3 CBCTs (i-CAT, Alphard VEGA, Implagraphy SC) and 1 MDCT (Somatom Emotion). The images were saved as DICOM format and CT numbers were measured using OnDemand 3D. CT numbers obtained from CBCTs and MDCT images were compared and linear regression analysis was performed for the density, ρ(g/cm 3 ), as the dependent variable in terms of the CT numbers obtained from CBCTs and MDCT images. CT numbers on i-CAT and Implagraphy CBCT images were smaller than those on Somatom Emotion MDCT image (p<0.05). Linear relationship on a range of materials used for this study were ρ=0.001 H+1.07 with R2 value of 0.999 for Somatom Emotion, ρ=0.002 H+1.09 with R2 value of 0.991 for Alphard VEGA, ρ=0.001 H+1.43 with R2 value of 0.980 for i-CAT and ρ=0.001 H+1.30 with R2 value of 0.975 for Implagraphy. CT numbers on i-CAT and Implagraphy CBCT images were not same as those on Somatom Emotion MDCT image. The linear regressive equations to determine the density from the CT numbers with very high correlation coefficient were obtained on three CBCT and MDCT scan.