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Sample records for mankin dmitri martila

  1. THE RELIABILITY OF THE MANKIN SCORE FOR OSTEOARTHRITIS

    NARCIS (Netherlands)

    van der Sluijs, J.A.; GEESINK, RGT; van der Linden, A.J.; BULSTRA, SK; Kuijer, Roelof; DRUKKER, J

    For the histopathological classification of the severity of osteoarthritic lesions of cartilage, the Mankin score is frequently used. A necessary constraint on the validity of this scoring system is the consistency with which cartilage lesions are classified. The intra- and interobserver agreement

  2. Sem dnei Medvedeva / Dmitri Kossõrev

    Index Scriptorium Estoniae

    Kossõrev, Dmitri

    2008-01-01

    Venemaa presidendi ametis oldud 100 päevast osutusid Dmitri Medvedevile viimased seitse problemaatiliseks. Autori sõnul on Vene-Gruusia sõjaline konflikti vaid tõstnud tema populaarsust venelaste hulgas

  3. Janybek Khan and Prince Liubartas-Dmitry

    Directory of Open Access Journals (Sweden)

    Ya.V. Pilipchuk

    2013-11-01

    Full Text Available This study focuses on the relations between the Volyn principality of Liubartas-Dmitry and the Ulus of Jochi under the rule of Janybek Khan. Liubartas-Dmitry ascended the throne of the Eastern Volyn largely due to the will of Uzbek Khan. The Land of Berestia together with the Eastern Volyn was the Liubartas’ appanage land in Volyn. As Boleslaw-Yuri II, Liubartas-Dmitry was compelled to pay tribute to the Tatars. During the War of the Galicia-Volyn legacy, Liubartas acted as a vassal of the Ulus of Jochi and ally of Uzbek Khan. Liubartas’ relations with Janybek Khan were fundamentally different from his previous relations with Uzbek Khan. Casimir III enjoyed greater sympathy of the Golden Horde khan due to the payment of tribute. Except for the campaign of 1351–1352, Janybek was hostile towards Lithuania. Only the common hostility of the Poles and Hungarians towards the Volyn and Podolia forced the khan of Ulus of Jochi to intervene on the side of the Lithuanians. For Janibek the western vector of his foreign policy was not a priority. He could accept the loss of a tribute from several Slavic principalities in exchange for success on other fronts, more profitable in terms of the spoils of war. Unlike the Koriatoviches and Olelkoviches, the Gediminoviches of Volyn were more peacefully disposed towards the Tatars since during the “Great Disorder” their land-holdings did not increase at the expense of Jochid possessions.

  4. Dmitri Krõmovist on saanud vaatemängumeister / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    Vene lavastaja Dmitri Krõmovist ja tema lavastusest "Söör Vantes. Donki Hot" (Anatoli Vassiljevi Teater Draamakunstikool. Dmitri Krõmovi loomelaboratoorium), mida etendatakse festivalil "Talveöö unenägu 2006"

  5. Arhitekt Anton Soansi valitsusaeg 1923-1928 / Dmitri Bruns

    Index Scriptorium Estoniae

    Bruns, Dmitri, 1929-

    2004-01-01

    Tallinna linnaplaneerimisest aastail 1923-1928, mil linnaarhitektiks oli Anton Soans. Arhitekt Anton Soansi elust ja tööst. Eelnev vt. Bruns, Dmitri "Tallinna kujunemine aastail 1918-1940", nr. 9, lk. 88-90, nr. 10, lk. 74-76

  6. DMITRY KITSENKO’S EARLY CREATION FOR ORGHAN

    Directory of Open Access Journals (Sweden)

    BEREZOVICOVA TATIANA

    2017-06-01

    Full Text Available The article deals with two works by Dmitry Kitsenko’s for organ solo, created at the early stage of his work: the Prelude and Fugue to the Memory of D. Shostakovich (1979 and the Suite for Organ (1980 which are analyzed from the point of view of form, musical language and performance.

  7. Books and Game-Review: Metro 2033 und Metro 2034 - von Dmitry Glukhovsky

    OpenAIRE

    Karl H. Stingeder

    2013-01-01

    Karl H. Stingeder rezensiert die beiden postapokalyptischen Romane Metro 2033 und Metro 2034 von Dmitry Glukhovsky, die auch in einer Spielversion auf den Markt gebracht wurden. Ein typischer Fall für unseren stellaren Spielexperten, der uns in die multimediale Welt der Science Fiction entführt.

  8. Books and Game-Review: Metro 2033 und Metro 2034 - von Dmitry Glukhovsky

    Directory of Open Access Journals (Sweden)

    Karl H. Stingeder

    2013-03-01

    Full Text Available Karl H. Stingeder rezensiert die beiden postapokalyptischen Romane Metro 2033 und Metro 2034 von Dmitry Glukhovsky, die auch in einer Spielversion auf den Markt gebracht wurden. Ein typischer Fall für unseren stellaren Spielexperten, der uns in die multimediale Welt der Science Fiction entführt.

  9. Modern theory of dynamical systems a tribute to Dmitry Victorovich Anosov

    CERN Document Server

    Katok, Anatole; Hertz, Federico Rodriguez

    2017-01-01

    This volume is a tribute to one of the founders of modern theory of dynamical systems, the late Dmitry Victorovich Anosov. It contains both original papers and surveys, written by some distinguished experts in dynamics, which are related to important themes of Anosov's work, as well as broadly interpreted further crucial developments in the theory of dynamical systems that followed Anosov's original work. Also included is an article by A. Katok that presents Anosov's scientific biography and a picture of the early development of hyperbolicity theory in its various incarnations, complete and partial, uniform and nonuniform.

  10. THE ORGAN CONCERTO BY DMITRY KITSENKO: PECULIARITIES OF ITS MULTIMEDIA VERSION

    Directory of Open Access Journals (Sweden)

    COCEAROVA GALINA

    2015-09-01

    Full Text Available The article presents the multimedia version of the Organ concerto by composer Dmitry Kitsenko – the work presented at different stages of his creation in various genre forms, as a result there appeared a kind of supercycle, consolidated by intertextual connections. The multimedia transformation of the Concerto by introducing the visual range based on the works of Albrecht Dürer modifi es the basic concept of this work which requires a new approach to its analysis. The author defi nes its main directions and describes the main features, with an emphasis on the screen material and its relationship with the musical component.

  11. Everyday Language Used by Dmitry Medvedev, the President of Russian Federation, as an Image Strategy Too

    Directory of Open Access Journals (Sweden)

    Ирина Сергеевна Смирнова

    2011-09-01

    Full Text Available This article is devoted to the analysis of the most frequent use of everyday language used in the speeches and statements of President Dmitry Medvedev. From the research it becomes clear that the main target is the Russian audience. However, some statements of this type aim also to influence foreign listeners and readers. At the same time, one purpose is to influence internal recipients differently from external recipients. This means that everyday language plays a different role in domestic communication from that in international communication and needs to be analyzed separately.

  12. Modeling sub-sea permafrost in the East Siberian Arctic Shelf: the Dmitry Laptev Strait

    International Nuclear Information System (INIS)

    Nicolsky, D; Shakhova, N

    2010-01-01

    The present state of sub-sea permafrost modeling does not agree with certain observational data on the permafrost state within the East Siberian Arctic Shelf. This suggests a need to consider other mechanisms of permafrost destabilization after the recent ocean transgression. We propose development of open taliks wherever thaw lakes and river paleo-valleys were submerged shelf-wide as a possible mechanism for the degradation of sub-sea permafrost. To test the hypothesis we performed numerical modeling of permafrost dynamics in the Dmitry Laptev Strait area. We achieved sufficient agreement with the observed distribution of thawed and frozen layers to suggest that the proposed mechanism of permafrost destabilization is plausible.

  13. Mirrors in Russian Decadent and Symbolist Prose: Valery Briusov and Dmitry Merezhkovsky

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    Kirsten Lodge

    2010-06-01

    Full Text Available Examining mirror imagery in the prose works “In the Mirror” by Valery Briusov and The Resurrected Gods: Leonardo da Vinci by Dmitry Merezhkovsky, both published in 1902, this article situates the Russian Decadent and Symbolist associations of the mirror in the pan-European literary and philosophical context. The mirror constitutes the threshold of manifold oppositions, including life and art, life and death, and reality and dream or imagination. It is a realm of alternative reality, magical and seductive, as in Briusov’s story, or potentially both demonic and divine, as in Merezhkovsky’s novel. In accordance with the Romantic tradition as well as Decadent and Symbolist iconography, mirror imagery in these two works is inseparable from questions of the nature of art and the power of artistic creation.

  14. THE ORGAN CONCERTO BY DMITRY KITSENKO: THE AUTHOR’S VIEW FROM THE PRESENT TO THE PAST OF UNIVERSAL CULTURE

    Directory of Open Access Journals (Sweden)

    COCEAROVA GALINA

    2015-06-01

    Full Text Available The article presents the history of the Organ concerto by composer Dmitry Kitsenko — the work which is acting at different stages of his creation in various genre forms. As a result repeatedly is modified the basic concept of this work, generating a kind of supercycle, united by intertextual connections. Characterizing the Organ concerto by Dmitry Kitsenko, the author also examines in more details his Concerto grosso No. 2, based on the same material and also defines the main features of both the audio-visual version of the Concerto, presented in the form of a multimedia opera on the Internet, using the works by A. Dürer, as well as the last purely musical version of the Concerto (2014.

  15. Meta-parody in contemporary Russian media: viewpoint blending behind Dmitry Bykov’s 2009 poem “Infectious”

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    Pleshakova Anna

    2016-06-01

    Full Text Available The author uses the case of Dmitry Bykov’s “Заразное” (Infectious to explore metaparody, a genre, which has received very little attention in literary studies and has not been explored from the cognitive poetic perspective so far. The author investigates Bykov’s performance of metaparody as a new Russian hybrid genre event, related to the new Russian ideology of nationalism, as well as the respective Kremlin-sponsored media discourse.

  16. AUTOBIOGRAPHY VS PHOTOGRAPHY AND MEMOIR VS CARICATURE AS FORMS OF PRESERVING THE AUTHOR’S MEMORY (DMITRY S. MEREZHKOVSKY

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    Аlexey А. Kholikov

    2017-03-01

    Full Text Available The essay focuses on visual images as one of the means of the writer’s reception on the example of such forms of preserving memory about Dmitry S. Merezhkovsky as autobiography and photography, on the one hand, and memoir and caricature, on the other. Photographic image comes close to autobiography in the following aspects. First, there is a functional affinity between these two forms, a verbal one and a visual one: both share the desire for authenticity. At the same time, photography as autobiography has not just documentary potential: photographic image is equally capable of reproducing and of reducing or distorting reality. Finally, photography (and this is its another affinity with a documentary genre presents not only individual and personal but also cultural and historical interest. Between caricature and memoir — another pair of media preserving verbal and visual memory about the writer — there are overlaps as well. These “spaces” of memory have bigger potential for interpretation of the image than photography or autobiography. I prove this point by analyzing specific details that were emphasized by caricatures and memoirs of Merezhkovsky. At the same time, I argue that caricature as a visual “space” of memory is not self-sustained the same way photography and portrait are. The other aspect the essay is concerned with the elements of the memory about the writer that remain untranslatable into visual language. Methodologically, the essay relies on the works by N.I. Zhinkin, Y.N. Tyanyanov, Y.M. Lotman, R. Barthes, and S. Sontag.

  17. South-East Asia: Emerging Regional Identity. Interview with prof. Dmitry Mosyakov (Institute of Oriental Studies of the Russian Academy of Sciences

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    Н С Куклин

    2017-12-01

    Full Text Available Dmitry Mosyakov, leading Russian expert on South-East Asia, graduated from the History and Philology Department of Institute of Asian and African Countries at Lomonosov Moscow State Uni-versity, majoring as an interpreter of the Khmer language in 1979. In 1979-1983 he studied in the post-graduate school of the Institute of Oriental Studies of the Academy of Sciences of the USSR. In 1983 he defended his thesis on the problems of the Pol Pot regime in Cambodia. He works for the Institute of Oriental Studies (IOS since 1985. In 1991, he was trained at the Yale University (USA. In 1994 he defended his doctoral dissertation on the modern history of Cambodia. He is the organizer of the multi-year project “Monitoring of the Modern History of Southeast Asian Countries”, within which the IOS hosts the annual inter-institute conference and, according to the results of the conferences, its materials are published in the peer-reviewed academic journal “Southeast Asia: To-pical Problems of Development”. Dmitry Mosyakov is an editor-in-chief of this journal. He is also the head of the center of South-Eastern Asia, Australia and Oceania of IOS, a member of the Academic Council of the IOS. He is a member of the dissertation council for historical sciences at the IOS, Moscow State Uni-versity, and of the editorial board of the journal “Asia and Africa Today”. Since 2001 he is a Professor and the head of the department of regional studies at the Moscow Humanitarian University (part-time. In 2015, Dmitry Mosyakov was the provisional director of the IOS. Since 2013 he is a member of Editorial Board of Vestnik RUDN. International Relations. The interview includes following topics: the state of development of the South-East Asian studies in Russia and abroad, the perception of international processes in the region, the contemporary problems of the South-East Asia, and the cooperation of Russia and the Eurasian Economic Union countries and integration

  18. Rezhissura momenta / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2006-01-01

    Šveitsi fotograafi Graham Mitchelli tööde näitusest "The Big Picture" Tallinna restoranis Pegasus. Autori kommentaarid. G. Mitchell on elanud pool aastat Tallinnas ning näitusefotod on tehtud Tallinnas ja selle ümbruses

  19. Koroleva babotshek / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Eesti päritolu Kanadas elavast kunstnikust Ruth Tulvingust ja tema kunstiprojektist "Liblikad" Narvas. 1997. aastast kingib kunstnik liblikaid kujutavad seinapannoosid Narva koolidele. Ruth Tulvingu personaalnäitus Vaal galeriis

  20. Zapetshatljonnaja priroda / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2006-01-01

    Rahvusvahelise loodusfoto konkursi Wildlife Photographer parimate tööde näitus "Loodusfoto 2005" Kumu Kunstimuuseumis. Peaauhinna sai itaallane Manuel Presti. Eestit külastab portreede kategoorias võitjaks tulnud Alexander Mustard. Tema riffahvena portreest

  1. Dmitri Borovkov tuli maailmameistriks!

    Index Scriptorium Estoniae

    2014-01-01

    6. septembril 2014 toimusid Poolas Szamotulys castingu maailmameistrivõistlused. Casting on spordiala, kus võisteldakse kauguse ja täpsuse peale, kasutades sportlikust kalapüügist tuntud heitevahendeid

  2. Piterskoje nastrojenije / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2006-01-01

    Vene saatkonna galeriis Tallinnas avatud Peterburi kunstnike ja fotograafide tööde näitusest "3+2". Larissa Golubeva, Rashid Dominovi, Valeri Mishini, Andrei (Villi) Ussovi ja Andrei Tshezhini töödest näitusel. Kuraator Larissa Golubeva

  3. Communication dated 2 April 2009 received from the Permanent Missions of the Russian Federation and the United States of America regarding a joint statement by Russian President Dmitry Medvedev and U.S. President Barack Obama

    International Nuclear Information System (INIS)

    2009-01-01

    The Secretariat has received a communication dated 2 April 2009 from the Permanent Missions of the Russian Federation and the United States of America, transmitting to the attention of all Member States of the IAEA a joint statement by Russian President Dmitry Medvedev and U.S. President Barack Obama issued on 1 April 2009. As requested in that communication, the attached statement is herewith circulated for the information of all Member States

  4. Motsart na kinoekrane / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    3. veebr. Tallinna Kinomajas Elijah Moshinsky ooperifilm "Mozart Türgis", mis põhineb W. A. Mozarti ooperil "Röövimine serailist" ("Haaremirööv"). Õhtu on Tallinna Filharmoonia ja Türgi saatkonna koostöös sündinud sarjast "Diplomaatilised noodid"

  5. Tshuzhoi Tanel Padar / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Saksamaalt pärit, Eesti ülikoolides filmiteooria ja -ajaloo loenguid pidav ja filmi "Ring tee" valmimist režissöörina juhtinud Dirk Hoyeri mängufilm esilinastub 27. apr. kinos "Sõprus". Praeguseks on film ümber nimetatud "Võõraks", ühes peaosadest astub üles muusik Tanel Padar

  6. Pulpa po-jevropeiski / Dmitri Kulikov

    Index Scriptorium Estoniae

    Kulikov, Dmitri

    2006-01-01

    Euroopa direktiivid nõuavad säästlikku suhtumist loodusesse, seetõttu peavad Narva Elektrijaamad kasutusele võtma uusi tehnoloogiaid ning muretsema kaasaegseid ja kalleid seadmeid elektrijaama jäätmete töötlemiseks

  7. Pesnja - trjohhminutnõi film / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2008-01-01

    26. aprillil esineb Tallinnas Serbia filmirežissöör Emir Kusturica koos Balkani ansambliga No Smoking Orchestra. Esitlusele tuleb muusika, mis kirjutatud režissööri filmile "Lubadus" ("Zavet"). Muusika autoriteks on ansambli juht Nele Karajlic ja režissöör ise

  8. Energetitsheskije peizazhi katalonskogo genija / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Kunstinäitusest "Joan Mir̤ maastikud" Kumus. Näitusel on kunstniku hilised abstraktsed maastikumaalid, graafikat, skulptuure ja fotosid. Eksponaadid pärinevad Pilar I Joan Mir̤ fondist Mallorcal. Kumu poolt koordineerib näitust Ragne Nukk, näituse kujundas Andres Tolts

  9. Tallinn-stolitsa telefonnogo servissa / Dmitri Kulikov

    Index Scriptorium Estoniae

    Kulikov, Dmitri

    2005-01-01

    Skandinaavias, Poolas ja vähesel määral ka Baltimaades tegutsev Softcom Customer Care plaanib Eestis rajada telefoniteenuste keskuse. Telefoniteenuseid pakkuvad firmad Eestis, Hilton Reservations Worldwide ja SAS Group Tallinna tütarfirmad

  10. Võrõpajev s "Eiforijei" / Dmitri Titorenko

    Index Scriptorium Estoniae

    Titorenko, Dmitri

    2006-01-01

    Tänavune Veneetsia filmifestival toimub 30. augustist 9. septembrini. Venemaad esindavad kolm mängufilmi : Ivan Võrõpajevi "Eufooria" (põhiprogrammis), Boriss Hlebnikovi "Svobodnoje plavanije" ( programmis "Horisondid"), Pavel Lungini "Saar" lõpetab festivali

  11. Maksuviidad 2017 / Maret Halikkma, Dmitri Rozenblat

    Index Scriptorium Estoniae

    Hallikma, Maret, 1975-

    2016-01-01

    Olulisemad muudatused maksuseadustes 2016-2017 ja 2018, olulisemad Riigikohtu lahendid (2015-2016), nn OÜtamisega seotud maksukontrollid, e-arvetele üleminek alates 01.01.2017, Anti Tax Avoidance Direktive (maksude vältimise vastane direktiiv) tagajärgedest, uue valitsuse maksupoliitika pakett aastateks 2016-2019

  12. 4 dnja v drugom formate / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    25.-28. okt. Teises Teatris toimuvast festivalist "Teine formaat 2. Sügishooaeg" (Drugoi format 2), mille programmis on muusikat, teatrietendusi, luulet, tantsulavastusi ja filme. Festivali organiseerija on Teise Teatri administraator Anastassia Kulkova

  13. "Gospodin Kino" i jego nekurjashtshii orkestr / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2008-01-01

    26. aprillil esineb Tallinnas Serbia filmirežissöör Emir Kusturica koos Balkani ansambliga No Smoking Orchestra. Esitlusele tuleb muusika, mis kirjutatud režissööri filmile "Lubadus" ("Zavet"). Muusika autoriteks on ansambli juht Nele Karajlic ja režissöör ise

  14. Peredel na rõnke piva / Dmitri Zvjagintsev

    Index Scriptorium Estoniae

    Zvjagintsev, Dmitri

    2003-01-01

    Viru Õlu poolt turule toodud odav õlu Bear Beer plastpudelites on suurte tootjate käibele mõjunud, suureneb importõlle osakaal. Õlleturul toimub turu ümberjaotus, see ei ole üksnes hindade vaid tootjatevaheline võitlus. Diagramm: õlleturg Eestis

  15. Tsennost starosti : dialog - kommentarii / Aleksei Turovski, Dmitri Mihhailov

    Index Scriptorium Estoniae

    Turovski, Aleksei, 1946-

    2003-01-01

    Vanade indiviidide vajalikkusest (loomariigis) liigi kui terviku seisukohast. Arutlus inimese uuest, eluiga pikendava tableti kasutamisel tekkivast alaliigist. Kommentaarid vestlusele "Anatomia starenija" (Raduga 2003 nr. 2, lk. 149-161)

  16. Dve golovõ za "Oskar" / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2008-01-01

    80. Oscarite galast. Joel ja Ethan Coeni mängufilm "Ei ole maad vanadele meestele" ("No Country for Old Men") võitis neli auhinda (parim film, režii, stsenaarium, meeskõrvalosa). Ka teistest võitjatest ja Venemaa Oscari nominentidest

  17. Tallinna kujunemine aastail 1918-1940 / Dmitri Bruns

    Index Scriptorium Estoniae

    Bruns, Dmitri, 1929-

    2004-01-01

    Tallinna linnaehituse ajaline jaotus linnaarhitektide isikute kaudu. Eugen Habermann Tallinna linnaplaneerijana (1918-1923). 3 ill. Järg: nr. 10, lk. 74-76, nr. 11, lk. 74-76 "Arhitekt Anton Soansi valitsusaeg 1923-1928", nr. 12, lk. 49-51 "Tallinna linnaehituslik areng linnaarhitekt Soansi ajastul"

  18. Tallinna linnaehituslik areng linnaarhitekt Soansi ajastul / Dmitri Bruns

    Index Scriptorium Estoniae

    Bruns, Dmitri, 1929-

    2004-01-01

    3 ill., s.h. E. Kühnerti ja R. Natuse koostatud Nõmme linna plaan (1926) ja Merivälja planeerimiskava (1924). Eelnev vt. D. Bruns "Tallinna kujunemine aastail 1918-1940", nr. 9, lk. 88-90, nr. 10, lk. 74-76, "Arhitekt Anton Soansi valitsusaeg 1923-1928, nr. 11, lk. 74-76. Järg vt. 2005. a., nr. 1, lk. 48-51. 4 ill.: Väike-Ameerika t., Pärnu mnt. ja raudtee vahelise ala, Narva mnt, A. Weizenbergi ja J. Poska t. vahelise ala ning Narva ja Tartu mnt. vahelise ala, s.h. Politseiaia planeerimiskavad (A. Soans), Pauluse kiriku kavand (E. Kuusik), nr. 2, lk. 47-49

  19. Problema ne v korruptsii, no v jevrobjurokratii / Dmitri Kulikov

    Index Scriptorium Estoniae

    Kulikov, Dmitri

    2005-01-01

    Eesti korrumpeerumise madal tase - 31. koht 145 riigi seas organisatsiooni Transparency International aruandes - tagab riigi konkurentsivõime ning välisinvestorite huvi. Konjunktuuriinstituudi uuring suhtumisest korruptsiooni

  20. Estonija : objomõ rastut - profil menjajetsja / Dmitri Kulikov

    Index Scriptorium Estoniae

    Kulikov, Dmitri

    2007-01-01

    Eesti transport otsib uusi kasvuvõimalusi - Vene transiidi olulisus, lennujaama ja sadamate areng, konteiner- ja autoveod. Diagrammid: Kaubavedu raudtee kaudu 2002-2006, sadamate kaudu 1999-2006, rahvusvaheliste kaubavedude jaotus

  1. Võiti zamuzh za Shtirlitsa! / Nonna Mordjukova ; interv. Dmitri Melman

    Index Scriptorium Estoniae

    Mordjukova, Nonna

    2008-01-01

    Vene näitlejanna endast ja oma suhtest oma esimese abikaasa Vjatsheslav Tihhonoviga, kellega ta elas 13 aastat. Samas meenutavad V. Tihhonovi ka tema lavapartnerid Svetlana Druzhinina ja Larissa Luzhina

  2. Rogozin : Topelttollid kaovad enne WTOd / Dmitri Rogozin ; interv. Toomas Sildam

    Index Scriptorium Estoniae

    Rogozin, Dmitri

    2002-01-01

    Venemaa Riigiduuma väliskomitee esimehe sõnul on Eestil ja Venemaal palju rohkem kokkupuutepunkte kui vastuolusid. D. Rogozin Venemaa välispoliitikast, NATO laienemisest itta, topelttollidest, õigeusu kiriku tülist

  3. Neft ne bõvajet oranzhevoi / Dmitri Bõkov

    Index Scriptorium Estoniae

    Bõkov, Dmitri

    2005-01-01

    Venemaa poliitiliste kriiside eripärast. Nn. sametrevolutsiooni eeldustest Aserbaidžaanis, president Ilham Alijev otsustab teostada revolutsiooni ülevalt, läbiviidud kaadrimuudatused, opositsiooni nõrkus. USA, Venemaa ja SRÜ vajavad stabiilset naftariiki

  4. Gravjurõ, finansõ i povsednevnost / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    SEB Eesti Ühispank väljastab uusi pangakaarte, millel on kujutatud motiive Eduard Wiiralti teostest. Pangakaartide väljaandmisega toetab pank koostöös Eesti Kunsti Toetusfondiga Eesti kunstiklassikute tööde restaureerimist. Toetusfondiga koostöös on valminud ka eksklusiivne Wiiralti kalender 2008. aastaks. Kujundas Karel Korp

  5. [Eelmiste perioodide maksudeklaratsioonide parandamise võimalusest] / Dmitri Jegorov

    Index Scriptorium Estoniae

    Jegorov, Dmitri, 1978-

    2005-01-01

    Alates juulist on tulu- ja sotsiaalmaksu, käibemaksu-, aktsiisi- ja INF deklaratsioonide parandamine võimalik vaid paberkandjal esitades see Maksu- ja Tolliameti teenindusbüroole. Lisatud: Õnneli Varend: EML täpsustab deklaratsioonide parandamise muudatust ; Lasse Lehis: deklaratsioonide paberil parandamine on tülikas

  6. Iskusstvo võbrasõvat musor / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Endise tehase "Polümeer" hoones asuvas galeriis Art Container avati grafiti-kunstnike Tõnise ja Jukku poolt maalitud klaastaara-konteinerite fotode näitus "Märka konteinerit". Samanimelisest kunstiprojektist

  7. Iskusstvo v gazete, gazeta v iskusstve / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2005-01-01

    "Eesti päevalehe" 100. sünnipäevale pühendatud rändnäitus "Ajaleht eesti kunstis" Adamson-Ericu muuseumis Tallinnas. Näha XX sajandi eesti kunstnike ajaleheteemalisi töid, karikatuure ja plakateid

  8. Digimaks ei hakka põhjustama guugeldamisreise / Dmitri Jegorov

    Index Scriptorium Estoniae

    Jegorov, Dmitri

    2017-01-01

    Eesti digimajanduse maksustamise muutuste mõjust. Vastus Kaido Künnapas, Mihkel Miidla ja Paul Künnapi artiklile "Kas pärast digimaksu kehtestamist tuleb guugeldamiseks minna Rootsi reisile?". Eesti Päevaleht, 2017, 9. okt.

  9. Animatsionnõi son v tjomnuju notsh / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2006-01-01

    23. nov. algab PÖFFi raames toimuv animafilmifestifal "Animated Dreams", mille raames näidatakse kinos "Sõprus" filme kuni 26. novembrini. Programmist, mis sel aastal on jaotatud kaheks : konkursi- ja eriprogrammiks. Saab näha ka eesti uut animatsiooni, muusikavideosid jne

  10. Renessansiaegsed meistritööd - Tallinna rae piltvaibad = Renaissance Masterpieces in Tallinn - Tapestries of the Town Hall Magistracy / Urve Mankin

    Index Scriptorium Estoniae

    Mankin, Urve

    2004-01-01

    1547. a. raesaali tellitud seitsmest Enghienis kootud piltvaibast. Kaks seinavaipa (140 x 860 cm, 140 x 830 cm) kujutavad maastiku taustal sündmusi kuningas Saalomoni elust ja tegevusest. Viis vaipa on rikkaliku taimornamendiga, nn verdüürid (laius 110 cm, pikkus 762, 757, 622, 555 ja 420 cm). Raekojas paiknevad praegu raevaipade koopiad

  11. Prokljatõje filmõ i dveri v nikuda / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Ameerika režissöör ja maalikunstnik David Lynch esineb 7. novembril kinos Kosmos loenguga "Film, Creativity and Consciousness". Ka filmist "Inland Empire". Eestisse kutsujateks olid Veiko Õunpuu, Rain Tolk ja Taavi Eelmaa

  12. Sdelki carry trade ne roskosh, a sredstvo nakoplenija / Darius Gecevicius, Dmitri Fokin

    Index Scriptorium Estoniae

    Gecevicius, Darius

    2007-01-01

    Strateegia carry trade kasutamisest valuutaturgudel. Carry trade on tehing, mis enamasti toimub valuutaturul, kus investor laenab raha sisse valuutas, mille intressid on madalamad ning paigutab selle valuutas, kus intressid on kõrgemad. Diagramm

  13. Kogda investitsionnõi dozhd prevratitsja v liven? / Aleksandr Fedotov, Sigitas Pashilaitis, Dmitri Kulikov

    Index Scriptorium Estoniae

    Fedotov, Aleksandr

    2006-01-01

    Ilmunud ka: The Baltic Course 2007 Winter (nr. 24) lk. 20-24. Põhjalik ülevaade välisinvesteeringutest Eestisse, Lätisse ja Leedusse. Diagrammid: Investeeringute struktuurid. Tabelid: Investeerimisprojektid

  14. Estonskije birzhevõje kompanii namnogo deshevle ihh zarubezhnõhh konkurentov / Dmitri Fokin

    Index Scriptorium Estoniae

    Fokin, Dmitri

    2008-01-01

    Hansabank Markets eksperdid arvavad, et Eesti ettevõtete aktsiad on alahinnatud välismaa konkurentide omadega võrreldes. Vt. samas: Troika lutshshihh mestnõhh birzhevõhh predprijatii. Tabel: Aktsii estonskihh birzhevõhh kompanii imejut horoshii potentsial rosta

  15. Pangajärelevalve ja e-panganduse areng / Toomas Kirt, Dmitri Sokolov

    Index Scriptorium Estoniae

    Kirt, Toomas

    2004-01-01

    Finantsinspektsioonist riikliku finantsjärelevalve teostajana. Baseli Pangajärelevalve Komitee standardite kogumist "Basel II" pankade kapitali adekvaatsuse seireks. Tabelid: E-panganduse sisu; Pankade vahendusel jaemaksete tegemise võimalused Eestis 2003. aasta lõpu seisuga

  16. Muzei gotovitsja k novoselju. Ekspozitsii otdõhajut. Audiogid iz Japonii / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2005-01-01

    17. novembril möödub 86 aastat Eesti Kunstimuuseumi asutamisest. KUMUs toimub ettekannete päev ja uue kunstiraamatu presentatsioon. Kunstimuuseumi kogudest. KUMU saab Jaapani valitsuselt kultuuritoetusena esitlus- ja restaureerimistehnikat

  17. Mõ võshli iz odnogo sojuza, vhodim v drugoi / Emilia Konstantinova ; interv. Dmitri Kulikov

    Index Scriptorium Estoniae

    Konstantinova, Emilia

    2003-01-01

    Bi-Info juht Emilia Konstantinova tutvustab Eesti eeliseid Euroopa Liiduga liitumisel, millised on uued võimalused ettevõtjaile. Bi-Info on firma, mis ainsana Eestist kuulub Euroopa-Aasia transpordi liitu

  18. USA sõdurid tulid Eestisse langevarjuhüppega / fotod: Dmitri Kotjuh

    Index Scriptorium Estoniae

    2016-01-01

    Sada Ameerika Ühendriikide 173. õhudessantbrigaadi õhudessantväelast sooritasid langevarjuhüppe Järvamaa Nurmsi murulennuväljale. Ameerika Ühendriikide sõjaväelased teevad kaasa õppuses Bayonet Strike, mis viiakse läbi kolmes Balti riigis ja Poolas

  19. Teatrikunstnik Iir Hermeliin - maagiline realist / Iir Hermeliin ; intervjueerinud Tiina Kolk, kommenteerinud Dmitri Demjanov, Evelin Kattai

    Index Scriptorium Estoniae

    Iir Hermeliin, pseud., 1973-

    2010-01-01

    Iir Hermeliini (Hille Ermel) teatritööst, talle olulistest paikadest Eestimaal, elust Kalamajas, välisreisidest, huvist kokanduse vastu, kunstiõpingutest, inspiratsiooniallikatest. Loetletud saadud autasud, valik lavastusi

  20. Tallinna linnaehituslik areng arhitekt Herbert Johansoni suunamisel aastail 1930-1940 / Dmitri Bruns

    Index Scriptorium Estoniae

    Bruns, Dmitri, 1929-

    2005-01-01

    1930-ndate keskel pöörasid Tallinna linnaplaneerijad põhitähelepanu ehitustegevuse elustamisele peatänavate ääres, linna laialivalgumise tõkestamisele, uusehitiste kvaliteedi parandamisele. H. Johansonist. Järg vt. nr. 7-8, lk. 53-55 "Tallinna linnaehituslik areng Herbert Johansoni juhtimisel 1934-1940" (Tallinna linnaplaani muudatused, Kopli poolsaare aedlinnaku planeerimine), nr. 9, lk. 38-40 "Tallinna areng Herbert Johansoni suunamisel" (esimeste suurmajade kerkimine Pärnu ja Narva maanteedele), nr. 10, lk. 42-44 "Herbert Johansoni viimased aastad linnaarhitektina" (Kadrioru pargi korrastamine, valmisid kabelid Metsa- ja Liiva kalmistul, mõned alustatud ehitistest valmisid pärast sõda)

  1. Füüsilise isiku tuludeklaratsioon = Income tax return for a natural person / Dmitri Jegorov

    Index Scriptorium Estoniae

    Jegorov, Dmitri

    2005-01-01

    Maksu- ja Tolliameti projekt "Füüsilise isiku tuludeklaratsioon" on täienenud automaatse kontrollsüsteemiga, mis annab maksumaksjale võimaluse enammakstud tulumaks tagasi saada viie tööpäeva jooksul

  2. Russia, NATO enlargement and the Baltic States / Konstantin Khudoley, Dmitri Lanko

    Index Scriptorium Estoniae

    Khudoley, Konstantin

    2004-01-01

    Autor analüüsib NATO laienemisprotsessi, sh Baltimaade liitumise mõju Venemaa välispoliitilistele seisukohtadele ja strateegiatele ning kirjeldab Venemaa ja NATO vahelise koostöö arendamise kolme võimalikku stsenaariumi

  3. Steven E. Miller and Dmitri V. Trenin, eds., The Russian Military: Power and Policy, Cambridge, MA: MIT Press, 2004.

    Directory of Open Access Journals (Sweden)

    Mikhail Tsypkin

    2005-10-01

    Full Text Available The Russian military largely went below the radar of Western interest after the disintegration of the Soviet Union.  More than a decade after the creation of the Armed Forces of the Russian Federation, they have become again the object of interest for scholars – this time, both Western and Russian, as demonstrated by the reviewed volume, whose editors assembled a group of extraordinarily knowledgeable experts from Russia and the West.  In his introduction, Steven Miller explains that the purp...

  4. Rezhissjor Vladimir Bortko : slozhnjeje "Mastera i Margaritõ" ne bõlo nitshego / Vladimir Bortko ; interv. Dmitri Bõkov

    Index Scriptorium Estoniae

    Bortko, Vladimir

    2006-01-01

    Režissöör oma teleseriaalist "Meister ja Margarita" M. Bulgakovi romaani järgi. Lisatud Juri Kara sama romaani ekraanile siiani pääsemata variandis osalenud näitlejate Nikolai Burljajevi, Valentin Gafti ja Viktor Pavlovi arvamusi uuest seriaalist

  5. Eesti SMEAR-jaama andmete kasutus jätkusuutliku biomassi tootmise jälgimisel / Steffen M. Noe, Alisa Krasnova, Dmitri Krasnov, Ahto Kangur

    Index Scriptorium Estoniae

    2015-01-01

    Atmosfääri ja biosfääri vastastikuse mõju uurimise jaama SMEAR-i abil on võimalik seirata ja pikaajaliselt koguda andmeid metsaökosüsteemi süsinikuringet mõjutavate tunnuste kohta erinevatel ökosüsteemi tasanditel ja suure mõõtmissagedusega

  6. Kak zhit v Jevropeiskom Sojuze? : ZAO "Ferteksos Transportas" = What will the life in the European Union be like? : The Fertexos Transportas private limited company / Dmitri Artamoshkin

    Index Scriptorium Estoniae

    Artamoshkin, Dmitri

    2003-01-01

    Transpordifirma "Fertexos" esindaja räägib ettevõtte transpordi - ja ekspedeerimisteenuste ning Leedu transpordisektori arendamisest arvestades territooriumi läbivaid rahvusvahelisi transpordikoridore ja Euroopa Liidu transpordipoliitika nõudeid

  7. "Novõi Stern" A. A. Shahhovskogo i traditsija J. B. Knjazhnina : (k probleme intertekstualnõhh pereklitshek v russkoi dramaturgii natshala XIX veka) / Dmitri Ivanov

    Index Scriptorium Estoniae

    Ivanov, Dmitri

    2003-01-01

    Kirjanik A. A. Shahhovski komöödias "Uus Stern" (1805) esitatud "tundliku kangelase" ja "veidriku" teemade intertekstuaalne võrdlus J. B. Knjazhnini komöödiaga "Veidrikud" (1790) ja koomilise ooperiga "Nesthastije ot karetõ" (1779)

  8. Esteet Hartshenko contra mehed punases / Heili Vaus-Tamm

    Index Scriptorium Estoniae

    Vaus-Tamm, Heili, 1961-

    2007-01-01

    Tantsuetendustest Kumu Kunstimuuseumis: "Red ain't dead", koreograaf - lavastajad Kaarel Väli, Kristjan Rohioja; tantsuteatri Zick esituses "Piaf", koreograaf - lavastaja Dmitri Harchenko. Dominiiklaste kloostri klausuuris "Reisijuht", koreograaf - lavastaja Dmitri Harchenko

  9. Krasotshnõje snõ Sed Arte Gallery / Irina Butjajeva

    Index Scriptorium Estoniae

    Butjajeva, Irina

    2007-01-01

    Valgevene kunstnike Jelena Shlegeli, Vladimir Gontsharuki, Dmitri Zenkovitshi ja Dmitri Masli maalinäitus "Valgevene värvilised unenäod" Tallinna galeriis Aatrium. Näitust vahendas Sed Arte Gallery, galerist Olga Ljubaskina

  10. Tervishoiutöötaja kriminaalvastutus ettevaatamatus surma põhjustamises = Healt care providers criminal liability of causing negligent homicide : [bakalaureusetöö] / Urmela Kraas ; Tartu Ülikool, õigusteaduskond ; juhendaja: Dmitri Teplõhh

    Index Scriptorium Estoniae

    Kraas, Urmela, 1988-

    2013-01-01

    Tervishoiutöötaja vastutuse statistikast Eestis ja kriminaalvastutuse kohtupraktikast ettevaatamatu surma põhjustamise eest, ettevaatamatu surma põhjustamisest tervishoiutöötaja poolt Eestis, USA-s ja Inglismaal

  11. Preliminary results of the research at corded ware sites in the Narva-Luga interfluve Estonian-Russian borders area in 2008-2014 / Aivar Kriiska, Kekko Nordqvist, Dmitri V. Gerassimov, Sarita Sandell

    Index Scriptorium Estoniae

    2015-01-01

    2008-2014. aastatel aset leidnud kaevamiste käigus on avastatud umbes 1000 km2 suuruselt alalt üle 40 uue kinnismuistisedateeringuga 5100-2000 eKr. Savinõude sarnasus uuritud alal osutab Narva-Lauga piirkonna ühtsele keraamikatraditsioonile

  12. Ülestähendusi Birgitta festivalilt 2009 / Raili Sule

    Index Scriptorium Estoniae

    Sule, Raili, 1944-

    2009-01-01

    13.-23. augustini Pirita kloostri varemetes toimunud Tallinna Filharmoonia korraldatud Birgitta festivali raames toimunud Dmitri Bertmanni lavastustest - Umberto Giordano "Siber" ja Giuseppe Verdi "Falstaff"

  13. Pojushtshije tela / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2007-01-01

    10. apr. Kumu Kunstimuuseumis tantsuteatri Zick esituses etenduvast tantsulavastusest "Piaf", koreograafia ja kujunduse on teinud Dmitri Harchenko, video koostanud Einar Lints, valguskujundus Triin Hook

  14. Seeing the Elephant: Looking Beyond China

    Science.gov (United States)

    2012-06-01

    index.php?option=com_content&task=view&id=18769&Itemi d=134 (accessed 1 May 2012). 47 Masha Charnay, “Dmitry Medvedev’s new assault on corruption in...AsiaOne+News/World/Story/A1Sto ry20110917-299954.html (accessed 19 May 2012). Chamay, Masha . “Dmitry Medvedev’s new assault on corruption in Russia

  15. Rogozin võib saada Moskva esindajaks NATO juures / Ravil Khair Al-Din

    Index Scriptorium Estoniae

    Al-Din, Ravil Khair

    2007-01-01

    Vene riigiduuma liige Dmitri Rogozini võib saada Venemaa NATO-esindajaks. Vt. samas: Mihkelson: kaks kärbest ühe hoobiga. Riigikogu EL-i asjade komisjoni esimees Marko Mihkelson nimetab kaks eesmärki, mida võib teenida Dmitri Rogozini võimalik nimetamine Venemaa NATO-esindajaks

  16. Eestlaste (uskumatud) seiklused Handimaal / Anzori Barkalaja

    Index Scriptorium Estoniae

    Barkalaja, Anzori, 1968-

    2008-01-01

    Eesti delegatsiooni osalemisest soome-ugri rahvaste V maailmakongressil Hantõ-Mansiiskis, Venemaa presidendi Dmitri Medvedevi ja Vene Riigiduuma väliskomisjoni esimehe Konstantin Kossatshovi esinemisest kongressil. Juuresoleval fotol president Toomas Hendrik Ilves, proua Evelin Ilves ja Venemaa president Dmitri Medvedev. Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  17. Restoran Cha Dao = Restaurant Cha Dao

    Index Scriptorium Estoniae

    2012-01-01

    Tallinnas Suur-Patarei 2 asuva Hiina restorani Cha Dao sisekujundusest. Restorani mööbel, v.a toolid, projekteeriti eritellimusena. Sisearhitekt Dmitri Pisarenko (DM3 OÜ), loetletud tema töid. Arhitekt Meeli Truu

  18. Territorija kino / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2004-01-01

    VIII Pimedate Ööde Filmifestivali filmidest : Joel Schumacher "Ooperifantoom", Kim Ki-duk "Tühi maja", Matthew Vaughn "Kihiline kook", Marco Bellocchio "Tere hommikust, öö", Oliver Hirschbiegel "Allakäik", Dmitri Meshijev "Omad"

  19. Oceanographic profile Zooplankton biomass measurements collected using net in the Antarctic during 1989 (NODC Accession 0000971)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Composition of the metazoan plankton was studied during R.V. "Dmitry Mendeleev" cruise 43 (February to April, 1989) in the Atlantic sector of the Southern Ocean....

  20. Kuidas maitsevad võistlusroad? / Siiri Kirikal

    Index Scriptorium Estoniae

    Kirikal, Siiri, 1966-

    2010-01-01

    14. jaanuaril 2010 toimus KUMU kunstimuuseumi auditooriumis kokkade olümpiaks tituleeritud Bocuse d’Or 2010 Eesti kandidaadi väljaselgitamine. Suvel Genfis toimuval Bocuse d’Or Europe 2010 valikvõistlusel esindab Eestit Dmitri Rooz

  1. Õigeksmõistev otsus vallandas publiku tormilise aplausi / Tiiu Põld ; kommenteerinud David Vseviov ; Marju Lauristin

    Index Scriptorium Estoniae

    Põld, Tiiu, 1945-

    2009-01-01

    Harju maakohtu õigeksmõistvast otsusest aprillirahutuste korraldamises süüdistatavate Dmitri Linteri, Maksim Reva, Dimitri Klenski ja Mark Sirõki kohta. Kommenteerivad David Vseviov ja Marju Lauristin

  2. Leto v Russkom teatre

    Index Scriptorium Estoniae

    2007-01-01

    Augustis Vene Teatri alternatiivsel laval "Garaaž" : 9. augustil "Veerevad kivid ei sammaldu", lavastaja Nikita Grinshpun (Moskva) ja 7., 8. augustil Aleksandr Potuzhnõi lavastus "Jõgi asfaldil", autor Dmitri Lipskerov

  3. Kaubamajast välja jooksid sõbralikud väed... / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    2002-01-01

    Uuema vene kunsti näitus "Ristumised" Hansapanga galeriis. Eksponeeritud Dmitri Gutovi ja grupi "Radek" video "Demonstratsioon", Vadim Zahharovi scratch-dokfilm "Unustuse järv" ja Sergei Shutovi installatsioon "Abakus"

  4. Alteration of rRNA gene copy number and expression in patients ...

    African Journals Online (AJOL)

    Irina S. Kolesnikova

    2017-09-01

    Sep 1, 2017 ... Asia R. Shorina d, Alexander S. Graphodatsky a, Ekaterina M. Galanina b, Dmitry V. Yudkin a,b,* ... rRNA gene copy numbers on affected acrocentric chromosomes in .... estimated using MS Excel software (Microsoft, USA).

  5. Алексий II 1929-2008

    Index Scriptorium Estoniae

    2008-01-01

    Aleksius II meenutavad: Kornelius, Tallinna ja kogu Eesti metropoliit ; Karin Jaani ; Marina Kaljurand ; Dmitri Medvedev, Venemaa president ; Helene Kamzol, Aleksius II sugulane ; Ain Seppik ; Vladimir Illjashevitsh ; Edgar Savisaar ; Jevgeni Tomberg ; Ene Ergma ; Toomas Hendrik Ilves, Eesti Vabariigi president

  6. President Medvedev: Putiniga võistlemist on raske ette kujutada / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    Venemaa presidendi Dmitri Medvedevi intervjuust ajalehele Financial Times. Medvedevi sõnul esindavad tema ja Vladimir Putrin suuresti sama poliitilist jõudu ning on raske ette kujutada Putiniga koos kandideerimist

  7. Robertsonian translocation 13/14 associated with rRNA genes ...

    African Journals Online (AJOL)

    Robertsonian translocation 13/14 associated with rRNA genes overexpression and intellectual disability. Alexander A. Dolskiy, Natalya A. Lemskaya, Yulia V. Maksimova, Asia R. Shorina, Irina S. Kolesnikova, Dmitry V. Yudkin ...

  8. Vene president Putin otsib endale sobivat mantlipärijat / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2006-01-01

    Venemaa president Vladimir Putin kavatseb 2008. aastal enam mitte presidendiks kandideerida ning otsib järgmist presidenti. Telekanal CNN pakkus kandidaatidena asepeaminister Dmitri Medvedjevit ja kaitseminister Sergei Ivanovi. Lisa: President ise küsib, ise vastab

  9. Teistmoodi pulmafotod / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2009-01-01

    Traditsioonilistest ja ebatraditsioonilistest tähtpäevafotodest. Dmitri Kotjuhi pildistatud pulmafotodest, kus on katsetatud erinevate keskkondadega. Tema fotosid on eksponeeritud näitusel "Argipäeva hetked"

  10. Kohtumine, mida Kreml igatseb / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2009-01-01

    Eelseisvast USA presidendi Barack Obama ja Venemaa presidendi Dmitri Medvedevi kohtumisest Londonis G20 tippkohtumise eel, kus tõenäoliselt arutatakse võimalusi kahe suurriigi omavaheliste suhete parandamiseks ning majanduskriisi ületamiseks

  11. Nastojashtshih hristjan nelzja prinudit / Aleksandr Men

    Index Scriptorium Estoniae

    Men, Aleksandr

    2001-01-01

    Osa Aleksander Men'i poolt ettevalmistatud Piibli-teemalisest sõnastikust : m ja n täht : vabamüürlus ja Piibel, Dmitri Merezkovski, Methodios, mormoonide Piibli-tõlgendus, Nikolai Morozov, mittekristlikud tunnistused Kristusest

  12. Lindpere lendab Norrasse, Kruglov jätkab Himkiga / Andres Kalvik

    Index Scriptorium Estoniae

    Kalvik, Andres, 1982-

    2007-01-01

    Poolkaitsja Joel Lindpere lendab Norrasse, kus näitab oma oskusi esiliiga meeskonnale Ham-Kam. Venemaa kõrgliiga uustulnuka FC Himkiga treeninud Eesti koondise vasakkaitsjal Dmitri Kruglovil puudub selgus, millises meeskonnas algaval hooajal mängib

  13. Kuumad tantsud ja Donki Hotid Eesti polaaröös / Margit Kask

    Index Scriptorium Estoniae

    Kask, Margit

    2007-01-01

    "Talveöö festival 2006" - "Söör Vantes. Donki Hot", lavastaja Dmitri Krõmov, Ghana tantsuansambli Kusum Gboo tantsusetendus "Somu" ja "Linnaelu kataloog" jaapanlase Issei Ogata esituses. Ka Jaak Alliku kommentaar festivalil nähtule

  14. Merkel: Nord Streami on meile vaja / Kalev Kask

    Index Scriptorium Estoniae

    Kask, Kalev

    2009-01-01

    Venemaa presidendi Dmitri Medvedevi ja Saksamaa kantsleri Angela Merkeli kohtumisel käsitleti energeetikapoliitikat, D. Medvedev kutsus Rootsit üles toetama Nord Streami arendamist ning taunis Nabucco gaasijuhtme rajamist

  15. Samozvantsev nam ne nado, komandirom budu ja / Maksim Shmeljov, Aleksandr Tshaplõgin, Leivi Sher

    Index Scriptorium Estoniae

    Shmeljov, Maksim

    2007-01-01

    Kas Konstitutsioonipartei nimekirjas parlamendivalimistel kandideeriv Dmitri Linter ja tema kaaslased võivad kasutada liikumise Notshnoi dozor brändi ND omakasupüüdlikel eesmärkidel, küsivad autorid

  16. Surev luik, ärkavad mälestused ja radioaktiivsus / Kairi Prints

    Index Scriptorium Estoniae

    Prints, Kairi, 1977-

    2010-01-01

    Koreograaf-lavastaja Dmitri Hartšenko loodud Tallinna Tantsuteatri tantsuetendus "Vestlus luigega", koreograaf Jenni Kivelä "Ballroom for Beginners" tantsuteater ZICK, Jo Strømgreni "The Experiment" Jo Strømgren Kompanii esituses

  17. Moskva maskid / Maris Johannes

    Index Scriptorium Estoniae

    Johannes, Maris, 1959-

    2008-01-01

    14. Venemaa riiklikust teatrifestivalist "Kuldne mask" 27. märtsist 15. aprillini Moskvas. Pikemalt auhinnatud töödest: Lev Dodini "Elu ja saatus" (Peterburi Väike Draamateater), Mindaugas Karbauskise "Lugu õnnelikust Moskvast" (Tabakovi teater Moskvas), Dmitri Krõmovi "Deemon. Vaade ülalt" (Draamakunsti kool Moskvas). Samuti ka Andrii Zholdaki lavastusest "Carmen. Exodus" ja Dmitri Krõmovi lavastusest "Lehm"

  18. Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration

    International Nuclear Information System (INIS)

    Nebelung, Sven; Brill, Nicolai; Tingart, Markus; Jahr, Holger; Pufe, Thomas; Kuhl, Christiane; Truhn, Daniel

    2016-01-01

    To evaluate the usefulness of quantitative parameters obtained by optical coherence tomography (OCT) and magnetic resonance imaging (MRI) in the comprehensive assessment of human articular cartilage degeneration. Human osteochondral samples of variable degeneration (n = 45) were obtained from total knee replacements and assessed by MRI sequences measuring T1, T1ρ, T2 and T2* relaxivity and by OCT-based quantification of irregularity (OII, optical irregularity index), homogeneity (OHI, optical homogeneity index) and attenuation (OAI, optical attenuation index). Samples were also assessed macroscopically (Outerbridge classification) and histologically (Mankin classification) as grade-0 (Mankin scores 0-4)/grade-I (scores 5-8)/grade-II (scores 9-10)/grade-III (score 11-14). After data normalisation, differences between Mankin grades and correlations between imaging parameters were assessed using ANOVA and Tukey's post-hoc test and Spearman's correlation coefficients, respectively. Sensitivities and specificities in the detection of Mankin grade-0 were calculated. Significant degeneration-related increases were found for T2 and OII and decreases for OAI, while T1, T1ρ, T2* or OHI did not reveal significant changes in relation to degeneration. A number of significant correlations between imaging parameters and histological (sub)scores were found, in particular for T2 and OII. Sensitivities and specificities in the detection of Mankin grade-0 were highest for OHI/T1 and OII/T1ρ, respectively. Quantitative OCT and MRI techniques seem to complement each other in the comprehensive assessment of cartilage degeneration. Sufficiently large structural and compositional changes in the extracellular matrix may thus be parameterized and quantified, while the detection of early degeneration remains challenging. (orig.)

  19. Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration

    Energy Technology Data Exchange (ETDEWEB)

    Nebelung, Sven [Aachen University Hospital, Department of Orthopaedics, Aachen (Germany); Institute of Anatomy and Cell Biology, RWTH, Aachen (Germany); Brill, Nicolai [Fraunhofer Institute for Production Technology, Aachen (Germany); Tingart, Markus; Jahr, Holger [Aachen University Hospital, Department of Orthopaedics, Aachen (Germany); Pufe, Thomas [Institute of Anatomy and Cell Biology, RWTH, Aachen (Germany); Kuhl, Christiane; Truhn, Daniel [Aachen University Hospital, Department of Diagnostic and Interventional Radiology, Aachen (Germany)

    2016-04-15

    To evaluate the usefulness of quantitative parameters obtained by optical coherence tomography (OCT) and magnetic resonance imaging (MRI) in the comprehensive assessment of human articular cartilage degeneration. Human osteochondral samples of variable degeneration (n = 45) were obtained from total knee replacements and assessed by MRI sequences measuring T1, T1ρ, T2 and T2* relaxivity and by OCT-based quantification of irregularity (OII, optical irregularity index), homogeneity (OHI, optical homogeneity index) and attenuation (OAI, optical attenuation index). Samples were also assessed macroscopically (Outerbridge classification) and histologically (Mankin classification) as grade-0 (Mankin scores 0-4)/grade-I (scores 5-8)/grade-II (scores 9-10)/grade-III (score 11-14). After data normalisation, differences between Mankin grades and correlations between imaging parameters were assessed using ANOVA and Tukey's post-hoc test and Spearman's correlation coefficients, respectively. Sensitivities and specificities in the detection of Mankin grade-0 were calculated. Significant degeneration-related increases were found for T2 and OII and decreases for OAI, while T1, T1ρ, T2* or OHI did not reveal significant changes in relation to degeneration. A number of significant correlations between imaging parameters and histological (sub)scores were found, in particular for T2 and OII. Sensitivities and specificities in the detection of Mankin grade-0 were highest for OHI/T1 and OII/T1ρ, respectively. Quantitative OCT and MRI techniques seem to complement each other in the comprehensive assessment of cartilage degeneration. Sufficiently large structural and compositional changes in the extracellular matrix may thus be parameterized and quantified, while the detection of early degeneration remains challenging. (orig.)

  20. Validity of gradient-echo three-dimensional delayed gadolinium-enhanced magnetic resonance imaging of hip joint cartilage: A histologically controlled study

    Energy Technology Data Exchange (ETDEWEB)

    Zilkens, Christoph, E-mail: christoph.zilkens@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Orthopaedic Surgery, Moorenstraße 5, D-40225 Dusseldorf (Germany); Miese, Falk, E-mail: falk.miese@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstraße 5, D-40225 Dusseldorf (Germany); Herten, Monika, E-mail: Moherten@web.de [Univ Dusseldorf, Medical Faculty, Department of Orthopaedic Surgery, Moorenstraße 5, D-40225 Dusseldorf (Germany); Kurzidem, Sabine, E-mail: sabine.kurzidem@uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Orthopaedic Surgery, Moorenstraße 5, D-40225 Dusseldorf (Germany); Jäger, Marcus [Univ Essen, Medical Faculty, Department of Orthopaedic Surgery, D-45147 Essen (Germany); König, Dietmar, E-mail: Dietmarpierre.koenig@lvr.de [LVR Clinic for Orthopedic Surgery, D-41749 Viersen (Germany); Antoch, Gerald, E-mail: antoch@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstraße 5, D-40225 Dusseldorf (Germany); Krauspe, Rüdiger, E-mail: krauspe@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Orthopaedic Surgery, Moorenstraße 5, D-40225 Dusseldorf (Germany); Bittersohl, Bernd, E-mail: bernd.bittersohl@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Orthopaedic Surgery, Moorenstraße 5, D-40225 Dusseldorf (Germany)

    2013-02-15

    Objective: To validate gradient-echo three-dimensional (3D) delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) by means of histological analyses in the assessment of hip joint cartilage. Materials and methods: Twenty-one femoral head specimens collected from 21 patients (7 males, 14 females, mean age: 60.9 ± 9.6 years; range: 37.6–77.3 years), who underwent total hip replacement for symptomatic hip joint osteoarthritis, underwent MRI and histological assessment. A region of 2 cm{sup 2} at the weight-bearing area was marked with four pins to enable multi-planar MRI reformatting to be matched with histological sections. MRI was performed at 3 T with a 3D double-echo steady-state (DESS) sequence for morphological cartilage assessment and 3D Volumetric Interpolated Breathhold Examination (VIBE) for T1{sub Gd} mapping. Histological sections were evaluated according to the Mankin score system. Total Mankin score, grade of toluidine staining (sensitive for glycosaminoglycan content) and a modified Mankin score classification system with four sub-groups of cartilage damage were correlated with MRI data. Results: Spearman's rho correlation analyses revealed a statistically significant correlation between T1{sub Gd} mapping and histological analyses in all categories including total Mankin score (r = −0.658, p-value ≤ 0.001), toluidine staining (r = −0.802, p-value < 0.001) and modified Mankin score (r = −0.716, p-value < 0.001). The correlation between morphological MRI and histological cartilage assessment was statistically significant but inferior to the biochemical cartilage MRI (r-values ranging from −0.411 to 0.525, p-values < 0.001). Conclusions: Gradient-echo dGEMRIC is reliable while offering the unique features of high image resolution and 3D biochemically sensitive MRI for the assessment of early cartilage degeneration.

  1. Ужель та самая "Русалка" / Наталья Веденеева

    Index Scriptorium Estoniae

    Веденеева, Наталья

    2009-01-01

    Aleksandr Puškin esitas näidendi "Näkineid" tervikuna ühel kirjandusõhtul 1836. a., kuid pärast tema surma avaldati see lõpetamata kujul. Kirjandusõhtul viibinud Dmitri Pavlovitš Zujev taastas mälu järgi näidendi lõpu ning avaldas selle 1876 a. ajakirjas Russki arhiv ("Русский архив"). Puškinistide arvamused teksti autorsuse kohta lahknesid. Küsimuse teksti ehtsuse kohta tõstatas taas tema järglane ja nimekaim Dmitri Zujev

  2. Festivali erinevad palged / Niina Kotsarenko ; tõlk. Madis Kolk

    Index Scriptorium Estoniae

    Kotsarenko, Niina

    2007-01-01

    Mõnedest selleaastasele teatrifestivalile "Talveöö unenägu 2006" iseloomulikest joontest. Erinevatest meistriklassidest, lühidalt etendustest: "Söör Vantes. Donki Hot" - lavastaja Dmitri Krõmovislandi, "Saja-aastane maja" Fru Emilia Teatri esituses, jaapanlase Issei Ogata monoetendus "Linnaelu kataloog" - lavastaja Yuzo Morita, Ghana tantsuansambli Kusum Gboo tantsusetendus "Somu" Richard Danguah lavastuses. Vene teatrikriitikustNatalja Krõmovast, tema sidemetest Eestiga ja tema raamatu "Nimed" presentatsioonist Linnateatris. Lk. 36-38 lühiintervjuud lavastaja Dmitri Krõmovi, tõlkija ja dramaturg Fredrik Linde ning festivali kunstilise juhi Jaanus Rohumaaga

  3. Uudiseid füüsikalaborist

    Index Scriptorium Estoniae

    2007-01-01

    TLÜ täppisteaduste valdkonnas on viimastel aastatel lisandunud uus uurimissuund: kõrgetemperatuurse plasma ja materjalide vastastikmõju, millega tegeletakse koostöös kolleegidega Varssavist, Prahast ja Moskvast. Uuringute läbi viimiseks ehitati valmis kaasaegne plasmafüüsika laboratoorium. Alates 2005. a. on TLÜ füüsikud kaasatud NATO "Teadus rahu eest" finantseeritavasse projekti. Prof. Romi Mankin selgitab füüsika valdkonna teadussuundi

  4. Assessment of Biomarkers Associated with Joint Injury and Subsequent Post Traumatic Arthritis

    Science.gov (United States)

    2015-10-01

    quantitative scales, and osteophyte score. Parametric analyses were performed for bone morphological measures and histological assessment. Mankin...p=0.0204) and the medial tibia (p=0.0015). Subchondral bone thickening was significantly increased in the C57BL/6 mice compared to the MRL/MpJ mice...modified synovitis score with semi-quantitative scales, and osteophyte score [1,5,6,7,8]. Parametric analyses were performed for bone morphological

  5. Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model.

    Science.gov (United States)

    Collins, K H; Paul, H A; Reimer, R A; Seerattan, R A; Hart, D A; Herzog, W

    2015-11-01

    Osteoarthritis (OA) may result from intrinsic inflammation related to metabolic disturbance. Obesity-associated inflammation is triggered by lipopolysaccharide (LPS) derived from the gut microbiota. However, the relationship between gut microbiota, LPS, inflammation, and OA remain unclear. To evaluate the associations between gut microbiota, systemic LPS levels, serum and local inflammatory profiles, and joint damage in a high fat/high sucrose diet induced obese rat model. 32 rats were randomized to a high fat/high sucrose diet (diet-induced obese (DIO), 40% fat, 45% sucrose, n = 21) or chow diet group (12% fat, 3.7% sucrose n = 11) for 28 weeks. After a 12-week obesity induction period, DIO animals were stratified into Obesity Prone (DIO-P, top 33% by change in body mass, n = 7), and Obesity Resistant groups (DIO-R, bottom 33%, n = 7). At sacrifice, joints were scored using a Modified Mankin Criteria. Blood and synovial fluid analytes, serum LPS, and fecal gut microbiota were analyzed. DIO animals had greater Modified Mankin scores than chow animals (P = 0.002). There was a significant relationship (r = 0.604, p = 0.001) between body fat, but not body mass, and Modified Mankin score. Eighteen synovial fluid and four serum analytes were increased in DIO animals. DIO serum LPS levels were increased compared to chow (P = 0.031). Together, Lactobacillus species (spp.) and Methanobrevibacter spp. abundance had a strong predictive relationship with Modified Mankin Score (r(2) = 0.5, P gut microbiota and adiposity-derived inflammation and metabolic OA warrants further investigation. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  6. Pikk mees ja lühike mees kohtuvad Kremlis / Enn Soosaar

    Index Scriptorium Estoniae

    Soosaar, Enn, 1937-2010

    2009-01-01

    USA presidendi Barack Obama eelseisvast kohtumisest Venemaa presidendi Dmitri Medvedeviga. Juttu on ka 15. juunil 2009 Washingtonis toimunud USA presidendi B. Obama ja Eesti presidendi Toomas Hendrik Ilvese plaanivälisest kohtumisest, viidates artiklile: Summertime blues. The Economist, 18. juuni 2009

  7. Estonia, Russia clash on the future of Finno-Ugric peoples / Paul Goble

    Index Scriptorium Estoniae

    Goble, Paul Alan, 1949-

    2008-01-01

    Hantõ-Mansiiskis toimunud soome-ugri maailmakongressist, president Toomas Hendrik Ilvese kohtumisest Venemaa presidendi Dmitri Medvedeviga, Eesti riigipea kõnest kongressil, Eesti delegatsiooni saalist väljamarssimisest Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatshovi sõnavõtu ajal. Vene ajakirjanduse reageeringust toimunule. Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  8. Genius of the periodic table

    International Nuclear Information System (INIS)

    1969-01-01

    'Isn't it the work of a genius!' exclaimed Academician V.I. Spitsyn, USSR, a member of the Scientific Advisory Committee when talking to an Agency audience in January. His listeners shared his enthusiasm. Academician Spitsyn was referring to the first formulation a hundred years ago by Professor Dmitry I. Mendeleyev of the Periodic Law of Elements. (author)

  9. Interesting signals from the Kremlin / Rokas M. Tracevskis

    Index Scriptorium Estoniae

    Tracevskis, Rokas M.

    2010-01-01

    Eesti president Toomas Hendrik Ilves ja Läti president Valdis Zatlers said Venemaa presidendilt Dmitri Medvedevilt kutse Teise maailmasõja võidu 65. aastapäeva tähistamise pidustustele Moskvas 9. mail 2010. Leedu president Dalia Grybauskaite pole kutset saanud, kuid teda on kutsutud Moskvasse visiidile talle sobival ajal

  10. Kuidas jutustada Anton Tšehhovit pooleteise tunniga? / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2011-01-01

    Tallinna Linnateatris toimunud teatrifestivalist "Talveöö unenägu", mis oli pühendatud vene teatrikunstnikule ja lavastajale Dmitri Krõmovile ning tema teatrilaboratooriumile. Lavastustest "Oksjon", "Katariina uned", "Oopus nr. 7". Festivali raames esitletud Natalja Krõmova raamatust "Kas te armastate teatrit?"

  11. Oscillations of the fusion cross-sections in the O+ O reaction

    Indian Academy of Sciences (India)

    consistent accounting for the dynamical deformations of the colliding nuclei within the ... MVC is grateful to the Dmitry Zimin Foundation 'Dynasty' for financial support. ... [5] P Fröbrich and R Lipperheide, Theory of nuclear reactions, in: Oxford ...

  12. Fine5 tantsuteater võitis Vitebskis teise preemia

    Index Scriptorium Estoniae

    2006-01-01

    22. - 26. XI Valgevenes toimunud kaasaegse koreograafia konkursil "International Festival of Modern Choreography" võitsid Laura Kvelstein ja Dmitri Kruus lühiteostega "1 spot, 2 shadows" teise preemia. Konkursi raames toimunud meistriklasse juhendas Fine5 koreograaf Tiina Ollesk

  13. Pattern Classification with Memristive Crossbar Circuits

    Science.gov (United States)

    2016-03-31

    Pattern Classification with Memristive Crossbar Circuits Dmitri B. Strukov Department of Electrical and Computer Engineering Department UC Santa...pattern classification ; deep learning; convolutional neural network networks. Introduction Deep-learning convolutional neural networks (DLCNN), which...the best classification performances on a variety of benchmark tasks [1]. The major challenge in building fast and energy- efficient networks of this

  14. Prima Vistale tuleb tuntud kirjanikke mitmest Euroopa riigist / Kaarel Kressa

    Index Scriptorium Estoniae

    Kressa, Kaarel, 1983-

    2010-01-01

    Prima Vista kirjandusfestivali külalisi: Leonie Swann, Attila Bartis, Dmitri Bõkov, Zinaida Lindén, Mihhail Šiškin, Fay Weldon, Jason Goodwin, Rosa Maria Rodríguez Magda, Inga Gaile, Juris Kronbergs, Guntars Godinš, Liana Langa

  15. Медведев и Обама подпишут новый договор START / Хендрик Восман

    Index Scriptorium Estoniae

    Восман, Хендрик

    2010-01-01

    USA president Barack Obama ja Venemaa president Dmitri Medvedev kavatsevad Prahas allkirjastada USA ja Venemaa vahelise tuumarelvalepingu, mille eesmärgiks on kahandada mõlema riigi tuumaarsenali. Pärast uue strateegilise relvastuse piiramise ehk STARTleppe allkirjastamist sööb USA president Prahas õhtust 11 Kesk- ja Ida-Euroopa riigipeaga, nende seas ka president Toomas Hendrik Ilvesega

  16. "Andke vene kunstnikele vaid toetuspunkt..." : intervjuu Moskva Riikliku Kaasaegse Kunsti Keskuse teaduri Irina Gorlovaga / Irina Gorlova ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Gorlova, Irina

    2002-01-01

    Irina Gorlova ja Leonid Bazhanovi kureeritud vene kunstnike Dmitri Gutovi, Sergei Shutovi ja Vadim Zahharovi näitusest "Ristumised" Hansapanga galeriis. I. Gorlova suhtumisest 1960ndate avangardistide põlvkonda, Ülo Soosterist, Ilja Kabakovist, sürrealismist ja praegusest vene kunstist, Oleg Kulikust, Aleksandr Brenerist, Aleksandr Ponomarjovist

  17. Kuidas tabada glamuuri / Irina Kiviselg

    Index Scriptorium Estoniae

    Kiviselg, Irina, 1961-

    2008-01-01

    Fotoglamuuri päev Jõhvi Kultuuri- ja Huvikeskuses. Dmitri Bazarovi töötuba "Mina olen fotomodell", Irina Kivimäe stuudio "Ahh, suvi!", Sergei Drozdiki meistrikoda. Vanade fotoaparaatide näitus. Fotokonkursi "Suvemälestus" võitis Aleksandr Bõstrov

  18. Fulltext PDF

    Indian Academy of Sciences (India)

    Pandit Vidyasagar. Shekhar Phatak and Associates. 1998, Rs.80. Engineering Drawing and Graphics -. AUTOCAD. K Venugopal. New Age International. 1998, Rs.19S . Mathematical Circles (Russian. Experience/. Dmitri Fomin, Sergey Genkin and. lIIia Itenberg. Universities Press. 1996, Rs.160. Stars and their life History.

  19. Merko Ehituse aktsialt oodatakse täna tulemuste tõttu tõusu / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2006-01-01

    Ilmunud ka: Delovõje Vedomosti 16. aug. lk. 25. Merko Ehituse teise kvartali kasum kasvas ligi 62% - 135,8 miljoni kroonini. Käive kasvas 41,2% - 1,17 miljardi kroonini. Diagrammid: Merko kasvatas tublisti kasumit. Vt. samas: Väikeaktsionär on lootusrikas. Venek. art. autor ka Dmitri Fokin

  20. Tshelovek na katsheljah vremeni : zametki s VIII kinofestivalja "Tjomnõje notshi" / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2004-01-01

    Pimedate Ööde Filmifestivalil nähtud filmidest. Pikemalt Simon Staho filmist "Päev ja öö", Jan Hrebejk' filmist "Üles-alla", Jerzy Stuhl'i filmist "Homne ilm", Guka Omarova "Skiso", Dmitri Meshijevi "Omad" ja Boris Hlebnikovi, Aleksei Popogrebski "Koktebel"

  1. S voinoi pokontshili mõ stshjotõ? / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2004-01-01

    PÖFFi filme - mängufilm Teise maailmasõja viimastest päevadest Berliinis, peategelaseks Adolf Hitler - "Allakäik" : režissöör Oliver Hirschbiegel : Saksamaa 2004 ja Dmitri Meshijevi sõjafilm "Omad" : Venemaa 2004

  2. Arctic Sea kaaperdaja: tellija oli Eerik-Niiles Kross / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2010-01-01

    Seitsmeaastase vanglakaristuse saanud kaubalaeva Arctic Sea kaaperdaja Dmitri Savins süüdistas Moskva kohtus endist luurekoordinaatorit Eerik-Niiles Krossi kuritöö tellimises, Kross eitab süüdistust ning Eesti prokuratuuril ja kaitsepolitseil pole andmeid Krossi asjaga seotuse kohta

  3. Arctic Sea saaga ikka ilma lõputa / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2011-01-01

    Arctic Sea väidetava kaaperdamise juhi Dmitri Savini väitel olevat temalt kaaperdamise tellinud Eesti luurekoordinaator Eerik-Niiles Kross. Eesti võimud ei ole seni Krossi ja laeva kaaperdamise vahel sidemeid tuvastanud, Krossi väitel on tegemist KGB-liku meetodiga tema maine rikkumiseks

  4. Arctic Sea arvatav kaaperdaja: ettevõtmise tellis Eerik-Niiles Kross

    Index Scriptorium Estoniae

    2010-01-01

    Kaubalaeva Arctic Sea kaaperdamises süüdi mõistetud Dmitri Savinsi sõnul oli kuritegu planeeritud lunaraha pärast ning operatsiooni tellijaks oli Eesti julgeolekuanalüütik ja ärimees Eerik-Niiles Kross

  5. 76 FR 7907 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2011-02-11

    ... PATRICK COYLE BRENDAN H D'ALVIELLA EUGENIE AIMEE GOBLET DARWIN ANGELA MARY BRUCE DAVID CARY RICHARD DAVID... ELIZABETH U FUNG PASCALE N GIBSON MATTHEW CHARLES GIBSON SARAH CLAIRE GIDRON GILLA MEZZAN GINDIN DMITRY... LINDA ANETTE HANSEN PAUL ROBERT HARDWICK III CHARLES CHEEVER HARRIS JANE VELDA HARSONO SUDARGO HARTLEY...

  6. Mis on hinge hind ehk Imet ei sündinud / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    1999-01-01

    Mängufilm "Ristumine peateega" : režissöör ja produtsent Arko Okk : Stsenarist oma näidendi järgi Jaan Tätte : Operaator Dmitri Jermakov : Kunstnik Pille Jänes : Helilooja Jukka Linkola : Acuba Film 1999. Lisa : Arko Oki elu ja loomingu lühikokkuvõte

  7. Siidii / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2003-01-01

    Heliplaatidest: Millenia Nova "Narcotic Wide Screen Vista", Trygve Seim "Different Rivers", Eesti Keeled ja Jaak Johanson, Riho Sibul "Sabaga Täht", Peeter Vähi, Fedor Vetkalov, Dmitri Tkachenko "Best Regards From Tallinn And Moscow", Brainstorm "A Day Before Tomorrow", Allegri, Pärt, Tormis "Light"

  8. Dzhorzh opjat poutshajet Vovu

    Index Scriptorium Estoniae

    2007-01-01

    George W. Bushi intervjuust agentuurile Reuters, kus ta puudutas Venemaa suhteid Läänega, USA plaani paigutada raketitõrjevahendid Poolasse ja Tšehhi. USA president George W. Bush kahtleb, kas president Vladimir Putini ajal Venemaa sammub demokraatia poole. Vene eksperdi Dmitri Abzalovi arvamus

  9. Auf den Spuren des verschollenen Polarforschers Baron Eduard Toll und seines Freundes Hermann Walter auf der Kotelny-Insel / Erki Tammiksaar, Roland Walter, Hans-Otto von Walter... [jt.

    Index Scriptorium Estoniae

    Tammiksaar, Erki, 1969-

    2011-01-01

    Baltisakslaste koostööst kuulsa vene polaaruurija Dmitri Šparoga seoses baltisaksa polaaruurija Hermann Walteri säilmete ringimatmisega Kotelnõi saarel. Hermann Walter osales Eduard von Tolli Sannikovi maa otsimise ekspeditsioonis. Hermann Walteri põhjalik iseloomustus

  10. Muusikamaailm : Viini pidunädalad algavad. Kammermuusika Wittenis. Ooper shostakovitshist. Erland von Koch ئ 90 / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2000-01-01

    Festivalist "Wiener Festwochen" 12.05-18.06. Saksamaal toimunud nüüdismuusikafestivalist "Tage für Neue Kammermusik Witten". Leipzigi Ooperis tuli maailmaesiettekandele L. Lombardi ooper "Dmitri", mis räägib D. shostakovitshi elust. E. von Kochi tegevusest

  11. Президент Эстонии : "Нужно снизить накал риторики" / Тоомас Хендрик Ильвес ; интерв. Наталья Тузовская

    Index Scriptorium Estoniae

    Ильвес, Тоомас Хендрик, 1953-

    2008-01-01

    President Toomas Hendrik Ilves räägib intervjuus BBC Venemaa toimetusele oma kõnest soome-ugri rahvaste maailmakongressil Hantõ-Mansiiskis, Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatšovi esinemisest, Eesti-Vene suhetest, kohtumisest Venemaa presidendi Dmitri Medvedeviga. Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  12. Venelased aja valguses ja varjus / Jüri Laulik

    Index Scriptorium Estoniae

    Laulik, Jüri, 1959-

    2010-01-01

    Pimedate Ööde Filmifestivalil linastuvatest vene filmidest: Aleksei Fedortšenko "Siisikesed" (2010), Aleksei Utšiteli "Ääremaa" (2010), Sergei Snežkini "Matke mind põrandaliistu alla" (2009), Dmitri Meshievi "Inimene aknal" (2010)

  13. Aasta pressifotod žürii perspektiivist / Annika Haas

    Index Scriptorium Estoniae

    Haas, Annika, 1974-

    2015-01-01

    Konkursist "Aasta pressifoto", pressifotograafide igapäevatööst. "Aasta pressifoto 2014" peapreemia pälvis Dmitri Kotjuhi "Noored suusatajad", portreefoto kategooria võitis Renee Altrovi "Eesti Vabariigi president", uudisfoto kategooria Margus Ansu "Klassijuhataja tunnid", olemusfoto kategooria Priit Simsoni "Kaotatud sõda"

  14. Statistical fingerprints of electoral fraud?

    NARCIS (Netherlands)

    Kobak, Dmitry; Shpilkin, Sergey; Pshenichnikov, Maxim S.

    2016-01-01

    Protests greeted the results of Russia's federal election in 2011, with accusations of vote-rigging and fraud. With the country heading to the polls again this September, Dmitry Kobak, Sergey Shpilkin and Maxim S. Pshenichnikov shine a light on several anomalies in the election data set.

  15. Kuulsuste keeruline elu : [anekdoodid] / Toomas Kall ; karikatuur: Rein Lauks

    Index Scriptorium Estoniae

    Kall, Toomas, 1947-

    2014-01-01

    Anekdoodid järgmistest kuulsustest: Luisa Värk, Taavi Rõivas, Ardo Hansson, Bill Gates, Nicolas Sarkozy, Dmitri Medvedev, Edgar Savisaar, Vladimir Putin, Anton Vaino, Astrid Kannel, Viktor Janukovitš, Evelin Ilves, Toomas Hendrik Ilves, Jürgen Ligi, Urve Palo, Indrek Tarand

  16. Soome-ugri rahvaste V maailmakongress = 5th world congress of finno-ugric peoples

    Index Scriptorium Estoniae

    2009-01-01

    President Toomas Hendrik Ilvese kohtumisest Venemaa presidendi Dmitri Medvedeviga, kõnest Hantõ-Mansiiskis toimunud soome-ugri maailmakongressil, Eesti delegatsiooni saalist väljamarssimisest Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatshovi sõnavõtu ajal. Väljavõtteid välisajakirjandusest. Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  17. В Русском театре играют мушкетеров / Ксения Репсон

    Index Scriptorium Estoniae

    Репсон, Ксения

    2011-01-01

    Natalja Lapina lavastab Vene Teatris Alexander Dumas romaani "Kolm musketäri" dramatiseeringut, osades noored näitlejad Ivan Aleksejev (Aramis), Mihhail Krjatšok (John Felton) ja Dmitri Kordas (Athos). Artiklis räägivad näitlejad, kes äsja lõpetanud teatrikoolid, oma teest Vene Teatri lavale

  18. Dostoevsky: A Collection of Critical Essays. Twentieth Century Views Series.

    Science.gov (United States)

    Wellek, Rene, Ed.

    One of a series of works aimed at presenting contemporary opinion on major authors, this collection includes essays by Rene Wellek, Philip Rahv, Murray Krieger, Irving Howe, Eliseo Vivas, D. H. Lawrence, Sigmund Freud, Dmitri Chizhevsky, V. V. Zenkovsky, Georg Lukacs, and Derek Traversi--all dealing with the biography and literary work of…

  19. Deterrence and Engagement: A Blended Strategic Approach to a Resurgent Russia

    Science.gov (United States)

    2016-04-15

    Expansionism “If you know the enemy and know yourself, you need not fear the result of a hundred battles.” – Sun Tzu , The Art of War. An analysis...55 Bibliography ...the U.S. and its European allies, could achieve greater stability and security for Europe. 57 Bibliography Adamsky, Dmitry. “If War Comes

  20. Illjuzii zimnei notshi / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2007-01-01

    "Talveöö festival 2006" - "Söör Vantes. Donki Hot", lavastaja Dmitri Krõmov. Ka Ghana tantsuansambli Kusum Gboo tantsuetendus "Somu", jaapanlase Issei Ogata monoetendus "Linnaelu kataloog" ja islandi "Saja-aastane maja" Fru Emilia Teatri esituses

  1. Exegi monumentum ehk palee Tallinnas / Siim Sultson

    Index Scriptorium Estoniae

    Sultson, Siim

    2007-01-01

    Tallinnas Narva mnt. 7 endisest Tsentrosojuzprojektist ümber ehitatud Triumph Plazast (arhitektid Vilen Künnapu ja Ain Padrik). Maja kavandati 1981. a. büroohooneks (arhitektid Olga Bruns ja Mart Kalling). Kommenteerivad Mart Port, Dmitri Bruns, Kristiina Möldre ja Ain Padrik

  2. Ammende pakub suvemuusikat / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2007-01-01

    Kontsertidest Pärnus Ammende villas: 5. juulil "Mõeldes Sinule" (Laura Põldvere, Jorma Toots, Marti Tärn, Ahto Abner), 12. juulil Kadri Voorand, Jürmo Eespere, Mihkel Mälgand ja Tanel Ruben, 19. juulil Tõnu Naissoo, Raul Vaigla ja Marko Naissoo kontserdiga "Tõnu Naissoo Eclectic Electric Trio", 26. juulil Holger Marjamaa kvartett (Holger Marjamaa, Mairo Marjamaa, Peedu Kass ja Dmitri Nikolajevski)

  3. Venemaa ja Prantsusmaa loovad liitu gaasi ja laevadega kaubeldes / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2010-01-01

    Venemaa presidendi Dmitri Medvedevi visiidist Prantsusmaale. Prantsusmaa peab läbirääkimisi nelja dessantlaeva Mistral müügiks Venemaale, Prantsuse energiafirma GDF Suez saab osaluse Nord Streamis ja Prantsusmaa ostab 2015. a. alates Venemaalt täiendavalt 1,5 mld kuupmeetrit gaasi

  4. "Shmatritsa" piterskogo Goblina / Aleksandr Lukjanov

    Index Scriptorium Estoniae

    Lukjanov, Aleksandr

    2003-01-01

    Peterburi tõlk Dmitri Putshkov on saanud tuntuks omalaadsete tõlkeparoodiatega : tuntud ameerika filmile tehakse oma tõlge-paroodia ja lisatakse vastav muusika. Selliselt töödelduna on saanud kultusfilmist "Matrix" "Shmatritsa". Nende filmide vaatajaskond on organiseerunud "Õige Tõlke Huviliste Klubiks"

  5. Aleksei Barabash : "Moi Aleksandr - pero, pushtshonnoje po vetru" / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2003-01-01

    Vitali Melnikovi ajalooline mängufilm Paul I-sest Dmitri Merezhkovski näidendi järgi "Vaene, vaene Paul" ("Bednõi, bednõi Pavel"). PÖFFil viibinud troonipärija Aleksandri rolli täitnud näitleja Aleksei Barabash räägib oma tööst selles filmis

  6. V "Ovode" Oleg Strizhenov fehtoval bez shpagi / Oleg Peranov

    Index Scriptorium Estoniae

    Peranov, Oleg

    2005-01-01

    Mängufilm "Kiin" ("Ovod") Ethel Lilian Voynichi romaani järgi : režissöör Aleksandr Faintsimmer : helilooja Dmitri Shostakovitsh : peaosas Oleg Strizhenov : NSV Liit 1955. Filmivõtetest ja vastuvõtust esilinastuse 50. aastapäeva puhul

  7. Суверенная мордва / Кира Латухина

    Index Scriptorium Estoniae

    Латухина, Кира

    2008-01-01

    Hantõ-Mansiiskis toimunud soome-ugri maailmakongressist, president Toomas Hendrik Ilvese kohtumisest Venemaa presidendi Dmitri Medvedeviga ja Eesti riigipea kõnest kongressil. Eesti delegatsiooni saalist lahkumisest Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatšovi sõnavõtu ajal. Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  8. Normaalsuse uuringud / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2010-01-01

    24.-27. septembrini Slovakkias Nitras toimunud rahvusvahelisest teatrifestivalist "Divadelna Nitra 2010". Pikemalt Dmitri Krõmovi lavastusest "Oopus nr 7", tantsulavastusest "Out of Context: For Pina" ("Kontekstist väljas, Pinale") koreograaf Alain Plateli trupi Les Ballets C de la B esituses ja Christoph Willibald Glucki ooperist "Orpheus ja Eurydike" Mariusz Trelinski lavastuses

  9. Vene uut kunsti ühendab mälu / Teet Veispak

    Index Scriptorium Estoniae

    Veispak, Teet, 1955-

    2007-01-01

    Näitusest "Mälu tagasitulek" Kumu Kunstimuuseumis, kuraator Viktor Misiano. Lähemalt David Ter-Oganjani (sünd. 1981) tööst "Vanad loosungid", Dmitri Prigovi (sünd. 1940) videost, Juri Leidermani installatsioonist "Isa jutustus", Jevgeni Fiksi tööst "Song of Russia"

  10. Litvinenko mõrva uurib Interpol / Tuuli Aug, Ravil Khair Al-Din

    Index Scriptorium Estoniae

    Aug, Tuuli

    2006-01-01

    Seoses Aleksandr Litvinenko mürgitamisega Londonis kuulati Venemaal üle ärimees Andrei Lugovoi. Saksa uurijad on veendunud, et polooniumi tõi Moskvast Saksamaale Dmitri Kovtun. Vene uurijad kavatsevad mõningatel andmetel Suurbritannias üle kuulata Boriss Berezovski ja Ahmed Zakajevi. Lisa: Polooniumijälg kui buldooserivagu

  11. Startup'i majanduse kiirkursus Tarifa palmide all / Erik Aru

    Index Scriptorium Estoniae

    Aru, Erik

    2012-01-01

    Eesti sotsiaalvõrgustikuprojekt Majakaja pääses nende hulka, kes said osaleda Hispaanias toimunud ärikiirendis Spanish Village. Majakaja on ühist kinnisvara omavate isikute võgustik. Selle asutajateks on Andrei Filimonov, Zahhar Kirillov ja Dmitri Semirenko

  12. Nordbiochem kujundab uut tööstusharu

    Index Scriptorium Estoniae

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke : v duhhe innovatsii 24. juuli lk. 5. Põlvas asuv keemiatööstus Nordbiochem ühendab maailma eri teadlaste töö, et luua ökonoomseid tehnoloogilisi protsesse, mis toodaksid taastuvast toorainest tööstuslikke keemiatööstuse sisendeid. Lisa: Faktid. Kommenteerivad Dmitry Murzin ja Tapio Salmi

  13. Kiwa Frankfurdis : great big fuck!

    Index Scriptorium Estoniae

    1999-01-01

    Frankfurdis 20.-21. XI toimunud kongressil Ida-Euroopa kunstist näitas kuraator Dmitry Vilensky enne oma ettekannet "Sõnum idast" Kiwa videot "Euro-Antivisioon. Kollase lipu all". D. Vilensky korraldatud illegaalsel posterite "näitusel" plankudel, kus Ida-Euroopa kunstnikud said avaldada arvamust Lääne kunstiinstitutsioonide strateegiate kohta, osalesid Aleksandr Brener, Oleg Kulik

  14. Järjest rohkem spordiinimesi kipub riigikokku / Gunnar Press

    Index Scriptorium Estoniae

    Press, Gunnar, 1957-

    2007-01-01

    Riigikogu valimistel kandideerib 21 spordiga seotud inimest. Vt. samas: Riigikogu valimised 2007, spordiinimeste TOP. Küsimustele vastavad: Dmitri Budõlin, Aleksei Budõlin, Margus Metstak, Erki Nool, Krista Kruuv, Aivar Kuusmaa, Mart Saarso, Andres Sõber, Andres Oper ja Aavo Põhjala

  15. Vene kirjandusest balti aktsendiga

    Index Scriptorium Estoniae

    2006-01-01

    24. nov. esitletakse Tallinnas Kirjanike majas almanahhi "Tuulelohe : vene kirjandus balti aktsendiga" ("Vozdushnõi zmei. Russkaja literatura s baltiiskim aktsentom"). Esinevad P. I. Filimonov, Deniss Kuzmin, Diana Efendijeva, Larissa Joonas, Dmitri Krasnov, Irina Meljakova, Jashka Gromova. Õhtut juhib almanahhi toimetaja Igor Kotjuh

  16. Civil Procedure in Cross-cultural Dialogue: Eurasia Context

    Directory of Open Access Journals (Sweden)

    Stefaan Voet

    2014-01-01

    Full Text Available Reviewed book: Civil Procedure in Cross-cultural Dialogue: Eurasia Context: IAPL World Conference on Civil Procedure, September 18–21, 2012, Moscow, Russia (Dmitry Maleshin, ed. (Statut 2012, available at (accessed March 9, 2014 [hereinafter Civil Procedure in Cross-cultural Dialogue: Eurasia Context].

  17. Literaturnaja lihhoradka

    Index Scriptorium Estoniae

    2007-01-01

    Vene kirjandusklassika ekraniseeringud : Lev Tolstoi romaani "Anna Karenina" ekraniseeringud, režissöör Sergei Solovjov; Dmitri Svetozarovi teleseriaal "Kuritöö ja karistus" ("Prestuplenije i nakazanije") Fjodor Dostojevski romaani järgi ja Felix Shultessi "Bessõ" F. Dostojevski järgi

  18. "Talveöö unenäo" imedest / Anne-Ly Sova

    Index Scriptorium Estoniae

    Sova, Anne-Ly, 1976-

    2007-01-01

    Teatrifestivalist "Talveöö unenägu 2006". Etendustest: "Söör Vantes. Donki Hot" - lavastaja Dmitri Krõmov, islandi "Saja-aastane maja" Fru Emilia Teatri esituses, jaapanlase Issei Ogata monoetendus "Linnaelu kataloog" - lavastaja Yuzo Morita, Ghana tantsuansambli Kusum Gboo tantsusetendus "Somu" Richard Danguah lavastuses

  19. Subjektiivselt Linnateatri kingitusest / Rait Avestik

    Index Scriptorium Estoniae

    Avestik, Rait, 1974-

    2007-01-01

    Teatrifestivalist "Talveöö unenägu 2006", etendustest: "Söör Vantes. Donki Hot" - lavastaja Dmitri Krõmov, Ghana tantsuansambli Kusum Gboo tantsusetendus "Somu", jaapanlase Issei Ogata monoetendus "Linnaelu kataloog" ja islandi "Saja-aastane maja" Fru Emilia Teatri esituses

  20. Talveöö uned / Maris Johannes

    Index Scriptorium Estoniae

    Johannes, Maris, 1959-

    2007-01-01

    Lühidalt meeldejäävast teatrifestivalil "Talveöö unenägu 2006", etendustest: "Söör Vantes. Donki Hot" - lavastaja Dmitri Krõmov, Ghana tantsuansambli Kusum Gboo tantsusetendus "Somu", jaapanlase Issei Ogata monoetendus "Linnaelu kataloog", islandi "Saja-aastane maja" Fru Emilia Teatri esituses ja Tallinna Linnateatri "Rätsep"

  1. Putini ja Medvedevi vahele tekib järjest rohkem ruumi / Jaanus Piirsalu

    Index Scriptorium Estoniae

    Piirsalu, Jaanus, 1973-

    2010-01-01

    Vene politoloogi Olga Krõštanovskaja hinnangul tunnetatakse Venemaal, et tekkimas on n.-ö. toetusgrupp nimelt Dmitri Medvedevile, mitte Putini-Medvedevi tandemile. Poliitikavaatleja Nikolai Svanidze hinnangul on ajakirjandus Venemaal muutunud veidi vabamaks. Märgata on avalikku kriitikat Vladimir Putini ja võimupartei Ühtne Venemaa kohta

  2. President läheb Moskvasse

    Index Scriptorium Estoniae

    2010-01-01

    President Toomas Hendrik Ilves teatas, et osaleb 9. mail 2010 Teise maailmasõja Euroopa lahingute lõpu aastapäeva üritusel Moskvas. President Dmitri Medvedevi isikliku kutse Eesti presidendile andis üle Venemaa suursaadik Eestis

  3. Liba-potteri papa tähetund / Ilona Martson

    Index Scriptorium Estoniae

    Martson, Ilona, 1970-

    2003-01-01

    Amsterdami kohtus arutati kevadel J. K. Rowlingi süüdistust Dmitri Jemetsi vastu, kes on avaldanud lasteraamatu "Tanja Grotter ja võlukontrabass". J. K. Rowlingi võidule vaatamata tundsid paljud Euroopa kirjastajad Frankfurdi messil raamatu tõlkimise vastu huvi

  4. Eesti arhitektid kuurordis suvitamas : 20.-21. augustil 2005 / Pille Epner

    Index Scriptorium Estoniae

    Epner, Pille

    2005-01-01

    Narva-Jõesuu sanatooriumis ja lähiümbruses toimunud Eesti Arhitektide Liidu IV suvepäevadest. Narva-Jõesuu ajaloost rääkis Epi Tohvri, ekskursiooni juhtis Mart Kalm. Seminaril "Tuleviku tehnoloogiad ja protsessid" esinenud John H. Frazeri, Inga Raukase, Dmitri Brunsi, Heiki Meose, suvepäevade peasponsori, Tšehhi klaasifirma Glaverbel esindaja Pavel Cumpeliku ettekannetest

  5. Kas Kiiev alistubki Gazpromile? / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2010-01-01

    Hiljuti pikendas Ukraina Vene mereväebaasi viibimist Sevastopolis, eile arutas Venemaa president Dmitri Medvedev Ukraina maagaasigigandi Naftogaz liitmist Gazpromiga. Venemaa pakub investeeringuid Ukraina majandusse, kuid samas on esitanud nimekirja Ukraina territooriumil asuvatest ehitistest ja objektidest, mida peab endale kuuluvaks. Ekspeaminister Julia Tõmošenko hinnangul lammutab Ukraina valitsus Ukraina riiki

  6. Biological and Clinical Characterization of Novel lncRNAs Associated with Metastatic Prostate Cancer

    Science.gov (United States)

    2014-10-01

    Matthew K. Iyer, Yang Shi, Xia Jiang, June Escara-Wilke, Rachell Brendenis, Dmitry Borkin, Anastasia K. Yocum, Dattatreya Mellacheruvu, Yuanyuan... Anastasia Yocum, Anton Poliakov, Vishal Kothari, Xiaojun Jing, Harika Gundlapalli, Xuhong Cao, Xiaoju Wang, Rohit Malik, PhD...Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry

  7. Research Article Special Issue

    African Journals Online (AJOL)

    pc

    2018-05-01

    May 1, 2018 ... Libraries Resource Directory. ... Institute of International Relations (MGIMO University), Moscow, Ru ... http://www.jfas.info ... In February 2017, following Putin's proposal, Russian Prime Minister Dmitry A. Medvedev ... citizens who independently and systematically earn on the services provision and work.

  8. Novaja holodnaja voina?

    Index Scriptorium Estoniae

    2007-01-01

    Briti ajaleht The Guardian kinnitab, et Venemaa ähvardab vastuseks USA plaanile paigutada Ida-Euroopasse raketitõrjesüsteem uue võidurelvastumisega, mis on võrreldav "külma sõja" ajal toimunuga. See on järeldus vestlusest Vene presidendi Vladimir Putini pressisekretäri Dmitri Peskoviga

  9. T2* mapping of hip joint cartilage in various histological grades of degeneration.

    Science.gov (United States)

    Bittersohl, B; Miese, F R; Hosalkar, H S; Herten, M; Antoch, G; Krauspe, R; Zilkens, C

    2012-07-01

    To evaluate T2* values in various histological severities of osteoarthritis (OA). Magnetic resonance imaging (MRI) and T2* mapping including a three-dimensional (3D) double-echo steady-state (DESS) sequence for morphological cartilage assessment and a 3D multiecho data image combination (MEDIC) sequence for T2* mapping were conducted in 21 human femoral head specimens with varying severities of OA. Subsequently, histological assessment was undertaken in all specimens to correlate the observations of T2* mapping with histological analyses. According to the Mankin score, four grades of histological changes were determined: grade 0 (Mankin scores of 0-4), grade I (scores of 5-8), grade II (scores of 9-10), and grade III (scores of 11-14). For reliability assessment, cartilage T2* measurements were repeated after 4 weeks in 10 randomly selected femoral head specimens. T2* values decreased significantly with increasing cartilage degeneration (total P-values fair correlation between T2* values and Mankin score (correlation coefficient = -0.362) that was statistically significant (P-value advantages of the T2* mapping technique with no need for contrast medium, high image resolution and ability to perform 3D biochemically sensitive imaging, T2* mapping may be a strong addition to the currently evolving era of cartilage biochemical imaging. Copyright © 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  10. Üldohtlik viis, kahe või enama isiku tapmine ja omakasu motiiv kui mõrva tunnused. Riigikohtu kriminaalkolleegiumi otsus asjas 3-1-1-36-09 / Elina Elkind

    Index Scriptorium Estoniae

    Elkind, Elina, 1982-

    2009-01-01

    Riigikohtu lahendist 3-1-1-36-09: Nikolai Galkovski kaitsja vandeadvokaat Anatoli Jaroslavski, Andrei Grišini kaitsja vandeadvokaat Leonid Olovjanišnikovi, Aleksandr Semjonovi kaitsja vandeadvokaat Oleg Nišajevi ja Dmitri Štšerbakovi kaitsja vandeadvokaat Toomas Alpi kassatsioonid Tallinna Ringkonnakohtu 24. novembri 2008. a kohtuotsuse peale kriminaalasjas Andrei Grišini süüdistuses KarS § 114 p-de 2, 3 ja 5 ja § 22 lg-te 2 ja 3, Dmitri Štšerbakovi süüdistuses KarS § 114 p-de 2, 3 ja 5, Aleksandr Semjonovi süüdistuses KarS § 114 p-de 2, 3 ja 5 ning Nikolai Galkovski süüdistuses KarS § 257, § 114 p-de 2, 3 ja 5 ja § 22 lg 3 järgi

  11. Zadonshchina, Ryazan, and the Moscow Princely Family

    Directory of Open Access Journals (Sweden)

    Alexander V. Lavrentyev

    2015-12-01

    Full Text Available This paper is devoted to the history and controversies surrounding the outstanding representative of Russian medieval literature from the late 14th century, the famous Zadonshchina. This work glorifies the military victory of the united forces of the Russian troops, led by Grand Prince Dmitry Donskoy, over the Tatar army on 8 September 1380, at Kulikovo Field near the Don River. This article presents arguments in favor of a Ryazan origin of the Zadonshchina text; furthermore, the article offers an explanation of the presence in the text of two “protagonists,” Grand Prince Dmitry Ivanovich and his cousin, Vladimir Andreyevich the Bold, Prince of Serpukhov. The joint rule of the “brothers” was a result of deaths caused by the plague in the Moscow ruling house, which took the dynasty to the brink of extinction. This feature of the political situation is reflected in the Zadonshchina text.

  12. Organizing the Cellular and Molecular Heterogeneity in High-Grade Serous Ovarian Cancer by Mass Cytometry

    Science.gov (United States)

    2013-10-01

    Acknowledgements The authors wish to thank Drs Scott Tanner, Olga Ornatsky, Dmitry Bandura , Mitch Winnik and Mark Nitz for their critical reading of this...Quality assurance for polychromatic flow cytometry using a suite of calibration beads. Nat Protoc 2012, 7:2067-2079. 23. Baranov VI, Quinn Z, Bandura ... Bandura DR, Tanner SD, Dick J: Multiple cellular antigen detection by ICP-MS. J Immunol Methods 2006, 308:68-76. 25. Ornatsky OI, Kinach R, Bandura DR

  13. German Business in Russia

    Directory of Open Access Journals (Sweden)

    Irakliy D. Gvazava

    2013-01-01

    Full Text Available Since Perestroika German-Russian relationships have been steadily developing fueled by close contacts between the leaders of both countries. Boris Yeltsin and Helmut Kohl, Vladimir Putin and Gerhard Schröder, Dmitry Medvedev and Angela Merkel had friendly relations resulted in some fruitful business projects, intergovernmental economic forums etc. In my article I will consider the activities of German companies in Russia, advantages, barriers and expectations

  14. Eesti kirjandus teisel pool merd ja piire

    Index Scriptorium Estoniae

    2016-01-01

    Islandi keeles ilmus Kätlin Kaldmaa lasteraamat "Lugu Keegi Eikellegitütre isast", Arvo Valton pälvis Venemaa kirjandusauhinna Dmitri Mizgulini raamatu "Kui päike oli jumalaks" 2015. a. parima tõlke eest ja Inglise luuleajakiri "Modern Poetry in Translation" andis välja antoloogia "Centres of Cataclysm", milles on avaldatud Kristiina Ehini luuletus"Merest tulevad lehmad"

  15. EU meets with Russia at Rostov-on-Don

    Index Scriptorium Estoniae

    2010-01-01

    31. mail Rostovis Doni ääres toimunud Venemaa ja Euroopa Liidu tippkohtumisel räägiti viisavabadusest, EL-i ja Venemaa vahelistest suhetest, Venemaa liitumisest Maailma Kaubandusorganisatsiooniga ja moderniseerimispartnerlusest. Kohtumisest võtsid osa Venemaa peaminister Vladimir Putin, president Dmitri Medvedev, Euroopa Liidu president Herman Van Rompuy, välispoliitika juht Catherine Ashton ja Euroopa Komisjoni president Jose ManuelBarroso

  16. Mälu defragmenteerimine / Ilja Sundelevitsh

    Index Scriptorium Estoniae

    Sundelevitsh, Ilja

    2007-01-01

    Viktor Misiano kureeritud projekt "Mälu tagasitulek" Kumu Kunstimuuseumis kuni 29. VII. Dmitri Gutovi projektist, mis koosneb videotest "Sula" ja "Kajakad" ning kolmest maalist, Valentin Arhipovi projektist "Vassili Grigorjevitsh Arhipovi looming aastail 1962-2006", Juri Leidermani heliinstallatsioonist "Isa jutustus", Jevgeni Fiksi projektist, Gljuklja & Tzaplja (Olga Jegorova, Natalja Pershina) installatsioonist "Punased purjed", Igor Shtsherbini tööst "Defragmenteerimine. Stirlitzi mälu" ja Sergei Bratkovi tööst

  17. В Центре русской культуры показывают "Живые картинки"

    Index Scriptorium Estoniae

    2009-01-01

    Näituse "Elavad pildid" avamine 13. novembril Tallinna Vene kultuurikeskuses. Näha on Peterburi kunstnike Jan Antonõševi (Ян Антонышев) ja Dmitri Jegorovski (Дмитри Егоровский) ning Eesti kunstnike Boriss Uvarovi ja Vitali Kuznetsovi maalid

  18. Civil-Military Relations in Medvedev’s Russia

    Science.gov (United States)

    2011-01-01

    Indeed, Dmitri Simes and Paul Saunders recently called it the glue that holds together the disparate groups that constitute Russia’s governing elite...corruption flour - ish, it also ties together the links between organized crime, the armed forces as a whole, their corruption, and the possibility of a...Internet Version, in English, May 16, 2007, Open Source Committee, FBIS SOV, May 16, 2007. 7. Andrei Illarionov, “The Siloviki in Charge,” Journal of

  19. Critical behavior of non-ideal systems

    CERN Document Server

    Ivanov, Dmitry Yu

    2008-01-01

    Dmitry Yu. Ivanov is a professor at the Baltic State Technical University (St. Petersburg, Russia). His research focuses on thermodynamics, critical phenomena and phase transitions, theoretical and experimental investigations of multiple light scattering and correlation spectroscopy in application to Material Science and critical phenomena. His research activities included projects at the Nuclear Research Center in Dubna and Krichevsky Laboratory (Russia) and at the CNRS laboratories and Universities of Paris and Nice (France). He has authored about 70 scientific publications.

  20. Ekspedeerimisfirmade TOP

    Index Scriptorium Estoniae

    2008-01-01

    Ekspedeerimisfirmade TOP 57. Vt. samas: Tanel Raig. Majandus kukutab ekspedeerimisturgu. Diagramm: Väliskaubanduse statistika; Katrin Raie. Ekspedeerijad hakkavad rohkem koostööle rõhuma. Kommenteerib Jaan Lepp; Müügitulu TOP 10; Müügitulu kasvu TOP 10; Kasumi TOP 10; Kasumi kasvu TOP 10; Rentaabluse TOP 10; Omakapitali tootlikkuse TOP 10; Eestis registreeritud Vene hiiglane; Ekspedeerimisturu kasumiliider kaotas 20 miljonit; Küsimustele vastab OÜ Contimer juht Dmitri Redkin

  1. Dale Herspring, The Kremlin and the High Command. Presidential Impact on the Russian Military from Gorbachev to Putin

    Directory of Open Access Journals (Sweden)

    Isabelle Facon

    2009-03-01

    Full Text Available In late 2008 Russian civil-military relations underwent a difficult period. Following the war in Georgia, the political leadership initiated new efforts to reform the military. Anatoly Serdiukov, the Russian Defense Minister, was appointed in 2007 by former president Vladimir Putin with a clear mandate to control military spending and eliminate many redundant senior officer posts. Concurrently, the new Russian president, Dmitri Medvedev, has affirmed his predecessor’s position that the condit...

  2. Авторитарный мир, где нет авторитетов / Елена Скульская

    Index Scriptorium Estoniae

    Скульская, Елена, 1950-

    2009-01-01

    Sergei Jurski raamatust "Кого люблю того здесь нет" (Moskva, 2008), mis on pühendatud silmapaistvate vene näitlejate, näitekirjanike, teadlaste ja lavastajate - Juri Jurski, Georgi Tovstonogovi, Faina Ranevskaja, Jevgeni Jevstignejevi, Aleksandr Volodini, Dmitri Pokrovski, Nikolai Volkovi, Simon Markiši - mälestusele

  3. Klavírní tvorba Dmitrije Kabalevského

    OpenAIRE

    MEZEROVÁ, Eva

    2017-01-01

    The aim of this thesis is to explore life, works and pedagogical benefits of the Russian composer Dmitry Borisovich Kabalevsky. I would also like to focus on children's piano instructive literature by D. Kabalevsky because it is very appreciative recitative methodological material widely used at elementary schools of art. The thesis also includes a methodological analysis of instructive compositions, formal analysis of piano sonatas and concertos aesthetic analysis.

  4. Western Political Consulting Techniques and Post-Soviet Political Technology in Political Campaigns in Latvia

    OpenAIRE

    Bērziņa, Ieva

    2012-01-01

    Western Political Consulting Techniques and Post-Soviet Political Technology in Political Campaigns in Latvia Ieva Dmitričenko Keywords: political campaignsm political consulting, political technology, parties, marketing, media Political campaigning is an international phenomenon, because there is a free flow of information, knowledge and human resource among practitioners of political campaigning in various countries. As a result political campaigning techniques that have proven to ...

  5. Grybauskaite rejects Obama's invitation / Rokas M. Tracevskis

    Index Scriptorium Estoniae

    Tracevskis, Rokas M.

    2010-01-01

    8. aprillil kirjutavad Ameerika Ühendriikide president Barack Obama ja Venemaa president Dmitri Medvedev Prahas uuele strateegilise tuumarelvastuse piiramise leppele alla. Samaks päevaks on Barack Obama Prahasse kutsunud Eesti, Läti, Leedu ja Rumeenia presidendid ning Poola, Tšehhi, Bulgaaria, Horvaatia, Ungari, Slovakkia ja Sloveenia peaministrid. Leedu president Dalia Grybauske loobus kutsest. Tema asemel sõidab kohtumisele peaminister Andrius Kubilius

  6. Tallinn nimetas Poska stipendiumi saajad

    Index Scriptorium Estoniae

    2006-01-01

    Tallinna linnavalitsus nimetas 10. mai istungil Jaan Poska stipendiumi saajad. Stipendium määrati kümnele Tallinna Tehnikaülikooli üliõpilasele : Eve Eenmaa, Andrus Räämet, Jelena Hartšenko, Andres Viia, Maksim Jenihhin, Raul Naadel, Martins Sarkans, Dmitri Šumigin, Külliki Tafel, Minna Varikmaa. Jaan Poska stipendium määratakse üliõpilasele silmapaistva ühiskondliku tegevuse eest Eesti ja Tallinna arengu heaks

  7. Area Handbook Series: Soviet Union: A Country Study

    Science.gov (United States)

    1989-05-01

    893 Bibliography Chapter 1 Auty, Robert, and Dmitry Obolensky (eds.). An Introduction to Rus- sian History, 1: Companion to Russian Studies. Cambridge...Panchenko, Chudnovskiy. Edinaia transportnaia sistema . Moscow: Transport, 1987. Guzhenko, T.B. (ed.). Morskoi transport SSSR: K 60-letiiu otrasli. Moscow...Resources (The BAM). New York: John Wiley and Sons, 1977. 952 Bibliography Shafirkin, B.I. Edinaia transportnaia sistema SSSR i vzaimodeistvie. Moscow

  8. Ильвес испортил праздник / Владимир Кузмин

    Index Scriptorium Estoniae

    Кузмин, Владимир

    2008-01-01

    President Toomas Hendrik Ilvese kohtumisest Venemaa presidendi Dmitri Medvedeviga, kõnest Hantõ-Mansiiskis toimunud 5. soome-ugri maailmakongressil. Eesti delegatsiooni saalist lahkumisest Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatšovi sõnavõtu ajal. Vabariigi President töövisiidil Venemaal 27.-30.06.2008. Ülevaade artiklist ilmunud ka: Current Digest of the Post-Soviet Press, 2008, nr. 26, lk. 12-13, pealk.: Ilves spoils the festivities

  9. „А вы в конец света верите?”. Апокалипсис в современной русской литературе: пророчества индейцев в романе Дмитрия Глуховского „Сумерки"

    OpenAIRE

    Szarycz, Ireneusz

    2012-01-01

    Dmitry Glukhovsky’s Sumerki (Twilight, 2007) is the story of a young Muscovite who takes up the task of decoding the prophecies of the Maya Indians and connects them with the catastrophes that plague today’s world: earthquakes in Iran, hurricanes in the USA, tsunamis in Indonesia, and drought and conflagrations in Russia. The newspaper headlines and TV news announcements look like Maya Indian prophecies. While translating the old diary of a Spanish conquistador, he becomes involved in a...

  10. Eesti tooraine: ebakvaliteetne või ülehinnatud? / Martin Hoffmann

    Index Scriptorium Estoniae

    Hoffmann, Martin

    2010-01-01

    Eesti müüdava liha, kala, köögivilja päritolust, kodumaise toodangu kvaliteedist. Asjatundjate hinnangul on Eestis küll väga head liha ja juurvilja, kuid nende kvaliteet kõigub ja tarnestabiilsus on halb. LM Keskuse müügijuhi Helgor Markovi, Horeca Sevice'i juhatuse liikme Raul Vaeti ja restoran Gloria peakoka Dmitri Demjanovi arvamusi ja hinnanguid

  11. Climate Change, Global Food Markets, and Urban Unrest

    Science.gov (United States)

    2013-02-01

    Francis Gavin 512-471-6267 3. DATES COVERED (From - To) Standard Form 298 (Rev 8/98) Prescribed by ANSI Std. Z39.18 - Climate Change, Global Food...Russia led then-President Dmitry Medvedev to impose export restrictions on wheat, barley, and rye . Food security is fundamental to human security. Prior...how much food is grown and where it is grown. Second, climate change will increase the frequency of localized crop failures due to more frequent

  12. Elupäästjate lood ja päästeteenistuse aumärkide saajad

    Index Scriptorium Estoniae

    2011-01-01

    Septembris 2001 aumärgid saanud päästjate nimekirjad. Pikemalt on kirjutatud järgmistest päästjatest: Aivar Issaev, Sulev Kase, Nail Beljalov, Lea Bärenson, Maidu Eru, Viktor Perets, Dmitri Bažura, Tarmo Klooster, Andres Leppenen, Tarmo Voltein, Karl Koort, Agu Annuk, Tiit Naan, Aare Ilves, Valentin Lossev, Oleg Kurilov, Vassili Sokolov, Alexander Soonvald, Alar Laanemägi, Tõivo Tim Nõlvak, Birko Kallas, Roland Kohv, Jevgeni Novikov

  13. U.S. and NATO Naval Engagement with Russia in the Black Sea: Historical Patterns and Current Prospects

    Science.gov (United States)

    2016-09-01

    encouraged its NATO Allies to march up and knock on the front door of Russian borders. In 2009, Dmitry Medvedev, then the Russian President, was one of...Vladimir Putin, Russian sports committee officials, and select Russian politicians claim that “It’s possible the U.S. is behind” the World Anti-Doping...rescue operations, joint maneuvers and communications, as well as sports activities, to build up a team spirit between Romanian and NATO forces.”142

  14. The Golden Age of Cataclysmic Variables and Related Objects - II Concluding Address

    Directory of Open Access Journals (Sweden)

    F. Giovannelli

    2015-02-01

    Full Text Available Before to conclude officially this workshop — far from me the idea to attempt some concluding remarks already dealt at the meeting with various burning by Joseph Patterson, Mariko Kato, Dmitry Bisikalo, and Rene Hudec —, I would like to comment few highlights coming out from our fruitful week of discussions about The Golden Age of Cataclysmic Variables and Related Objects - II, without any pretension of completeness.

  15. Moskvast tuli Eestisse Hõbe-Jüri / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2004-01-01

    Moskvas lõppes XXVI rahvusvaheline filmifestival. Festivali programmi kuulus ka Renee Reinumäe, Jaak Kilmi noortefilm, mis sai žürii eripreemia, Hõbedase Püha Jüri. Peapreemia sai venelase Dmitri Meshijevi "Omad". Noorte lootustandvate režissööride programmis oli huvitav prantslase Christophe Honoré "Minu ema". Lisatud auhinnatute nimekiri ning nimekiri "Eesti filmide tähtsamaid autasusid"

  16. Venemaa parandab Rüütli-Putini vestlust / Toomas Sildam

    Index Scriptorium Estoniae

    Sildam, Toomas, 1961-

    2005-01-01

    Vene presidendi asepressiesindaja Dmitri Peskovi sõnul on praegusel ajal võimalik ainult Molotovi-Ribbentropi pakti ajalooline hinnang ning Venemaale oleks parim variant, kui piirileping ja poliitiline deklaratsioon kirjutataks alla Teise maailmasõja lõpu 60. aastapäeva pidustuste ajal Moskvas. President Arnol Rüütel aga teatas pärast kohtumist Vladimir Putiniga, et Vene president nõustus lahutama piirilepingu poliitiliste suhete deklaratsioonist

  17. Environmental consequences associated with a large-scale blowout of oil in the former disputed area between Norway and Russia in the Barents Sea (a case study)

    OpenAIRE

    Rasmussen, Sigve Evenssønn

    2011-01-01

    Master's thesis in Environmental technology The former disputed area between Norway and Russia in the Barents Sea is of increasing interest when it comes to oil and gas exploration and production. The area is likely to open for exploration in the near future as the maritime delimitation and cooperation agreement between Norway and Russia concerning the Barents Sea were ratified by the Russian State Duma and signed by Russian President Dmitri Medvedev during the spring of 2011. The impact o...

  18. Ideed, mis muudavad maailma

    Index Scriptorium Estoniae

    2012-01-01

    Noorte ettevõtluskonkursi Ajujaht finalistidest: Richard Murutar (Dolphin), Andrus Purde (Achoo), Kalev Külaase, Ülane Vilumets, Rait Kapp (Kohalik Giid), Mart Raus, Vahur Mäe (Grillcube), Dmitri Kuznetsov, Anna Agronova, Julia Abolina, Anatoly Loginov (Healthiest.mobi), Karin Juhe, Karin Aruots (Korsid), Raino Sinisalu, Märt Pikkani, Arkadi Tammik, Varje Papp (Raybike), Egle Loit, Kair Käsper (Pille toidukott)

  19. Estonian Leader's Freedom Call Creates Storm / Anna Smolchenko

    Index Scriptorium Estoniae

    Smolchenko, Anna

    2008-01-01

    President Toomas Hendrik Ilvese esinemisest soome-ugri rahvaste maailmakongressil Hantõ-Mansiiskis, kohtumisest Venemaa presidendi Dmitri Medvedeviga, Eesti delegatsiooni saalist väljamarssimisest Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatshovi sõnavõtu ajal. Ilmunud ka: St. Petersburg Times 1. juuli 2008, pealk.: Estonian Leader's Freedom Call Creates Controversy (lüh.). Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  20. Lapsed kapsapõldudel mehe eest väljas / Anne Oja

    Index Scriptorium Estoniae

    Oja, Anne, 1970-

    2006-01-01

    Kadarbiku talu peremees Ants Pak kasutab oma põldudel 8-12-aastaste laste tööd. Vt. samas: Vanemad tohivad lapsi tööle panna vaid oma tallu ja pereettevõttesse. Vt. samas Gert D Hankewitz interv. talu peremehe Ants Pakìga: Vanem ise sokutab lapse meile. Kommenteerivad Alar Tamm, Tarmo Kriis, Mailis Reps, Juhan Salum, Janno Järve, Aivo Tamm, Dmitri Jegorov ja Liivi Lents

  1. Omad võõraste hulgas / Viktor Matizen ; tõlk. Tamara Korts

    Index Scriptorium Estoniae

    Matizen, Viktor

    2004-01-01

    Moskvas lõppes XXVI rahvusvaheline filmifestival. Peapreemia sai venelase Dmitri Meshijevi "Omad" ("Svoi"), FIPRESCI auhinna Marina Razbezhkina "Lõikuse aeg" ("Vremja zhatvõ"), publiku auhinna Vladimir Mashkovi "Isa" ("Papa!"), vene kriitikute auhinna brasiillase Heitor Dhalia "Nina", konkursi "Perspektiiv" auhinna jaapanlane Hideta Takahata ("Hotell Veenus") ja žürii eriauhinna Hõbedase Püha Jüri eestlaste Jaak Kilmi ja Rene Reinumägi "Sigade revolutsioon"

  2. Eesti Teadusfondi preemia Astrid Haljasele ja Tõnu Laasile

    Index Scriptorium Estoniae

    2000-01-01

    Eesti Teadusfondi täppisteaduste ekspertkomisjoni poolt korraldatud magistrantide ja doktorantide teadustööde konkursil määrati preemia 4000 krooni loodusteaduste osakonna teadurile Astrid Haljasele artikli Mankin, R., Ainsaar, A., Haljas, A. Trichotomous-noise-induced phase transitions for the stochastic Hongler model. Proc. Estonian Acad. Sci. Phys. Math., 2000, 49, 1, 28-39 eest. Loodusteaduste osakonna assistendile, TPÜ doktorandile Tõnu Laasile määrati preemia 7000 krooni artiklite sarja Lainete levik kõveras aeg-ruumis eest : [täistekst

  3. Chicken collagen type II reduces articular cartilage destruction in a model of osteoarthritis in rats.

    Science.gov (United States)

    Xu, D; Shen, W

    2007-06-01

    To evaluate the therapeutic effects of domestic chicken collagen type II (CCII) on rat osteoarthritis (OA) and analyze concomitant changes in the level of Matrix metalloproteinase (MMP)-13, MMP-9, Cathepsin K and their mRNA as well as the tissue inhibitor of matrix metalloproteinase (TIMP)-1 mRNA in articular cartilage of osteoarthritic rats. Osteoarthritis models were surgically induced. Morphology of articular cartilage was done by haematoxylin and eosin staining and Mankin score was calculated, immunohistochemistry of MMP-13, MMP-9 and Cathepsin K was done by ABC method while the mRNA level for MMP-13, MMP-9, cathepsin K as well as TIMP-1 was evaluated by RT-PCR method. Oral administration of CCII reduced the morphological changes of osteoarthritic cartilage (shown by Mankin score), decreased levels of MMP-13, MMP-9, cathepsin K as well as their mRNA in articular cartilage from osteoarthritic rats while it exhibited no effect on TIMP-1 mRNA. Oral CCII reduced articular cartilage degradation of osteoarthritic rats and may probably be a potent drug candidate for OA treatment.

  4. Morus alba L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis.

    Science.gov (United States)

    Khunakornvichaya, Arada; Lekmeechai, Sujinna; Pham, Phi Phuong; Himakoun, Wanwisa; Pitaksuteepong, Tasana; Morales, Noppawan Phumala; Hemstapat, Warinkarn

    2016-01-01

    This study was designed to investigate the anti-nociceptive effect of Morus alba stem extract as well as its cartilage protective effect in the anterior cruciate ligament transection (ACLT)-induced rat model of osteoarthritis (OA). The anti-nociceptive effect of this plant extract was determined by measuring hind limb weight bearing, while the severity of cartilage damage to the knee joints was evaluated using the modified Mankin grading system. Oral administration of M. alba stem extract (56 and 560 mg/kg) significantly attenuated joint pain as indicated by a significant (p alba stem extract at 56 and 560 mg/kg when compared to those of the vehicle-treated OA-induced group. In addition, a significant improvement in the Mankin score was also observed in rats treated with 560 mg/kg M. alba stem extract, which was in agreement with its pain-relieving effect. The results showed that M. alba stem extract exhibited an anti-nociceptive effect as well as cartilage protection in the ACLT-induced rat model of OA, supporting its potential use as a therapeutic treatment for OA. © 2016 S. Karger AG, Basel.

  5. Saaremaa Fond turgutab õppureid / Aare Laine

    Index Scriptorium Estoniae

    Laine, Aare, 1951-

    2012-01-01

    Saaremaa Fond andis kõrgkoolides häid õpitulemusi näidanud ja pere kõrvalt õppivatele tudengitele üle aastastipendiumid. Õppiva pere stipendium: Viljandi kultuuriakadeemias rahvuslikku käsitööd õppiv Alliki Oidekivi, Tallinna ülikoolis 2. kursusel kutsepedagoogikat õppiv Ahti Paju ning Tallinna ülikoolis magistriõppes haridustehnoloogiat õppiv Irena Sink. Peeter Palu nimeline stipendium: Eesti mereakadeemia tüürimehe eriala 2. kursuse tudengile Ott Kuusele. Tallinna Sadama nimelise stipendium: mereakadeemias tüürimehe eriala õppiv Dmitri Mišin

  6. Keskeakriis. Veeuputus pärast vihma / Vladimir Anshon ; tõlk. Madis Kolk

    Index Scriptorium Estoniae

    Anšon, Vladimir, 1963-

    2007-01-01

    Žürii liikme silmade läbi 11. rahvusvahelisest Praha lavastuskunstnike kvadriennaalist 14. - 20. VI 2007. Järgmistest väljapanekutest pikemalt: Eesti rahvuslik väljapanek (kuraator Ene-Liis Semper), Eesti Kunstiakadeemia väljapanek (kuraator Lilja Blumenfeld), Venemaa rahvuslik väljapanek, Läti Kunstiakadeemia väljapanek (kuraator Reinis Suhanovs), Venemaa rahvuslik väljapanek (kuraator Dmitri Krõmov), Portugali rahvuslik väljapanek (kuraator Joao Mendes Ribeiro), Mehhiko rahvuslik väljapanek

  7. 2010 ICA Panel on Methodologies for Studying Virtual Worlds

    DEFF Research Database (Denmark)

    Hansbøl, Mikala; Reinhard, CarrieLynn D.; Ho, Caroline

    2010-01-01

    strategies qualitatively from 00:12:00-00:19:30 •CarrieLynn D. Reinhard speaks about merging quantitative and qualitative methods from 00:19:30-00:29:30 •Mikala Hansbøl speaks about qualitative analysis of a serious educational game from 00:29:30-00:40:00 •The question and answer period is from 00:51:15-01:08:00......This video was produced from a panel discussion at the 2010 International Communication Association conference in Singapore. The panelists are Dmitri Williams (University of Southern California), Mikala Hansbøl (Danish School of Education), Caroline Ho (National Institute of Education, Singapore...

  8. Putini pärandus Medvedevile - Nõukogude stiilis hääletav Tšetšeenia / Jaanus Piirsalu

    Index Scriptorium Estoniae

    Piirsalu, Jaanus, 1973-

    2008-01-01

    Vladimir Putin tuli võimule seoses Tšetšeenia sõjaga, oma järglasele Dmitri Medvedevile pärandab ta tshetsheenlaste peaaegu täieliku lojaalsuse. Kõiki positiivseid muutusi Tšetšeenias seostatakse vaid kahe - Vladimir Putini ja Ramzan Kadõrovi - nimega. Lisa: Tšetšeenia lühike lähiajalugu. Vt. samas intervjuud Tšetšeenia presidendiga. Kadõrov: me olime ja oleme Venemaaga

  9. Ma tean, mida sa näitad end olevat teinud läinud suvel / Laura Kuusk

    Index Scriptorium Estoniae

    Kuusk, Laura, 1982-

    2006-01-01

    Kuraator Marco Laimre juhendamisel valminud Eesti Kunstiakadeemia III kursuse fotograafiaüliõpilaste suvepraktika tööde näitus "Ma tean, mida sa tegid läinud suvel / I know what you did last summer" Eesti Kunstiakadeemia galeriis kuni 3. X. Helina Kõrmi, Dmitri Gerassimovi, Kristjan-Jaak Tammiksaare, Anne-Mai Pällo, Tuuli Antsovi, Terje Ugandi, Ivar Veermäe, Riika Tauriaineni, Kätly Kaibaldi, Raul Viitungi ja Andrus Kaursoni töödest

  10. Atomic Pioneers Book 2 From the Mid-19th to the Early 20th Century

    Energy Technology Data Exchange (ETDEWEB)

    Hiebert, Ray [University of Maryland; Hiebert, Roselyn

    1971-01-01

    This book gives a brief account of the lives and work of 26 men and women who contributed to the great surge of knowledge vital to atomic science from the 1800s to the mid-1900s. The 26 are: William Prout, Michael Faraday, Eilhardt Mitscherlich, Joseph Henry, Thomas Graham, Stanislao Cannizzaro, James Clerk Maxwell, Dmitri I. Mendeleev, Joseph Norman Lockyer, John William Strutt, Wilhelm Konrad Roentgen, Antione Henri Becquerel, Hendrik A. Lorentz, J.J. Thomson, Max Planck, Svante A. Arrhenius, Pierre Curie, Marie Curie, Pieter Zeeman, Theodore W. Richards, C.T.R. Wilson, Ernest Rutherford, Francis W. Aston, Frederick Soddy, Lise Meitner, and Otto Hahn.

  11. One-Year Outcomes of Total Meniscus Reconstruction Using a Novel Fiber-Reinforced Scaffold in an Ovine Model.

    Science.gov (United States)

    Patel, Jay M; Merriam, Aaron R; Culp, Brian M; Gatt, Charles J; Dunn, Michael G

    2016-04-01

    Meniscus injuries and resulting meniscectomies lead to joint deterioration, causing pain, discomfort, and instability. Tissue-engineered devices to replace the meniscus have not shown consistent success with regard to function, mechanical integrity, or protection of cartilage. To evaluate a novel resorbable polymer fiber-reinforced meniscus reconstruction scaffold in an ovine model for 52 weeks and assess its integrity, tensile and compressive mechanics, cell phenotypes, matrix organization and content, and protection of the articular cartilage surfaces. Controlled laboratory study. Eight skeletally mature ewes were implanted with the fiber-reinforced scaffold after total meniscectomy, and 2 additional animals had untreated total meniscectomies. Animals were sacrificed at 52 weeks, and the explants and articular surfaces were analyzed macroscopically. Explants were characterized by ultimate tensile testing, confined compression creep testing, and biochemical, histological, and immunohistochemical analyses. Cartilage damage was characterized using the Mankin score on histologic slides from both the femur and tibia. One sheep was removed from the study because of a torn extensor tendon; the remaining 7 explants remained fully intact and incorporated into the bone tunnels. All explants exhibited functional tensile loads, tensile stiffnesses, and compressive moduli. Fibrocartilagenous repair with both types 1 and 2 collagen were observed, with areas of matrix organization and biochemical content similar to native tissue. Narrowing in the body region was observed in 5 of 7 explants. Mankin scores showed less cartilage damage in the explant group (femoral condyle: 3.43 ± 0.79, tibial plateau: 3.50 ± 1.63) than in the meniscectomy group (femoral condyle: 8.50 ± 3.54, tibial plateau: 6.75 ± 2.47) and were comparable with Mankin scores at the previously reported 16- and 32-week time points. A resorbable fiber-reinforced meniscus scaffold supports formation of functional

  12. The distribution pattern of critically short telomeres in human osteoarthritic knees

    DEFF Research Database (Denmark)

    Harbo, Maria; Bendix, Laila; Bay-Jensen, Anne Christine

    2012-01-01

    ABSTRACT: INTRODUCTION: Telomere shortening is associated with a number of common age-related diseases. A role of telomere shortening in osteoarthritis (OA) has been suggested, mainly based on the assessment of mean telomere length in ex vivo expanded chondrocytes. We addressed this role directly...... in vivo by using a newly developed assay, which measures specifically the load of ultra-short single telomeres (below 1,500 base pairs), that is, the telomere subpopulation believed to promote cellular senescence. METHODS: Samples were obtained from human OA knees at two distances from the central lesion...... site. Each sample was split into three: one was used for quantification of ultra-short single telomeres through the Universal single telomere length assay (STELA), one for histological Mankin grading of OA, and one for mean telomere length measurement through quantitative fluorescence in situ...

  13. Activation of Indian Hedgehog Promotes Chondrocyte Hypertrophy and Upregulation of MMP-13 in Human Osteoarthritic Cartilage

    Science.gov (United States)

    Wei, Fangyuan; Zhou, Jingming; Wei, Xiaochun; Zhang, Juntao; Fleming, Braden C.; Terek, Richard; Pei, Ming; Chen, Qian; Liu, Tao; Wei, Lei

    2012-01-01

    Objective The objectives of this study were to 1) determine the correlation between osteoarthritis (OA) and Ihh expression, and 2) establish the effects of Ihh on expression of markers of chondrocyte hypertrophy and MMP-13 in human OA cartilage. Design OA cartilage and synovial fluid samples were obtained during total knee arthroplasty. Normal cartilage samples were obtained from intra-articular tumor resections, and normal synovial fluid samples were obtained from healthy volunteers and the contralateral uninjured knee of patients undergoing anterior cruciate ligament reconstruction. OA was graded using the Mankin score. Expression of Ihh in synovial fluid was determined by western blot. Ihh, type X collagen and MMP-13 mRNA were determined by real time PCR. Protein expression of type X collagen and MMP-13 in cartilage samples were analyzed with immunohistochemistry. Chondrocyte size was measured using image analysis. Results Ihh expression was increased 2.6 fold in OA cartilage and 37% in OA synovial fluid when compared to normal control samples. Increased expression of Ihh was associated with the severity of OA and expression of markers of chondrocyte hypertrophy: type X collagen and MMP-13, and chondocyte size. Chondrocytes were more spherical with increasing severity of OA. There was a significant correlation between Mankin score and cell size (r2= 0.80) and Ihh intensity (r2 = 0.89). Exogenous Ihh induced a 6.8 fold increase of type X collagen and 2.8 fold increase of MMP-13 mRNA expression in cultured chondrocytes. Conversely, knockdown of Ihh by siRNA and Hh inhibitor Cyclopamine had the opposite effect. Conclusions Ihh expression correlates with OA progression and changes in chondrocyte morphology and gene expression consistent with chondrocyte hypertrophy and cartilage degradation seen in OA cartilage. Thus, Ihh may be a potential therapeutic target to prevent OA progression. PMID:22469853

  14. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.

    Science.gov (United States)

    Hayami, Tadashi; Zhuo, Ya; Wesolowski, Gregg A; Pickarski, Maureen; Duong, Le T

    2012-06-01

    To investigate the disease modifying effects of cathepsin K (CatK) inhibitor L-006235 compared to alendronate (ALN) in two preclinical models of osteoarthritis (OA). Skeletally mature rabbits underwent sham or anterior cruciate ligament transection (ACLT)-surgery and were treated with L-006235 (L-235, 10 mg/kg or 50 mg/kg, p.o., daily) or ALN (0.6 mg/kg, s.c., weekly) for 8-weeks. ACLT joint instability was also induced in CatK(-/-) versus wild type (wt) mice and treated for 16-weeks. Changes in cartilage degeneration, subchondral bone volume and osteophyte area were determined by histology and μ-CT. Collagen type I helical peptide (HP-I), a bone resorption marker and collagen type II C-telopeptide (CTX-II), a cartilage degradation marker were measured. L-235 (50 mg/kg) and ALN treatment resulted in significant chondroprotective effects, reducing CTX-II by 60% and the histological Mankin score for cartilage damage by 46% in the ACLT-rabbits. Both doses of L-235 were more potent than ALN in protecting against focal subchondral bone loss, and reducing HP-I by 70% compared to vehicle. L-235 (50 mg/kg) and ALN significantly reduced osteophyte formation in histomorphometric analysis by 55%. The Mankin score in ACLT-CatK(-/-) mice was ~2.5-fold lower than the ACLT-wt mice and was not different from sham-CatK(-/-). Osteophyte development was not different among the groups. Inhibition of CatK provides significant benefits in ACLT-model of OA, including: 1) protection of subchondral bone integrity, 2) protection against cartilage degradation and 3) reduced osteophytosis. Preclinical evidence supports the role of CatK as a potential therapeutic target for the treatment of OA. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Tenascin-C Prevents Articular Cartilage Degeneration in Murine Osteoarthritis Models.

    Science.gov (United States)

    Matsui, Yuriyo; Hasegawa, Masahiro; Iino, Takahiro; Imanaka-Yoshida, Kyoko; Yoshida, Toshimichi; Sudo, Akihiro

    2018-01-01

    Objective The objective of this study was to determine whether intra-articular injections of tenascin-C (TNC) could prevent cartilage damage in murine models of osteoarthritis (OA). Design Fluorescently labeled TNC was injected into knee joints and its distribution was examined at 1 day, 4 days, 1 week, 2 weeks, and 4 weeks postinjection. To investigate the effects of TNC on cartilage degeneration after surgery to knee joints, articular spaces were filled with 100 μg/mL (group I), 10 μg/mL (group II) of TNC solution, or control (group III). TNC solution of 10 μg/mL was additionally injected twice after 3 weeks (group IV) or weekly after 1 week, 2 weeks, and 3 weeks (group V). Joint tissues were histologically assessed using the Mankin score and the modified Chambers system at 2 to 8 weeks after surgery. Results Exogenous TNC was maintained in the cartilage and synovium for 1 week after administration. Histological scores in groups I and II were better than scores in group III at 4 and 6 weeks, but progressive cartilage damage was seen in all groups 8 weeks postoperatively. Sequential TNC injections (groups IV and V) showed significantly better Mankin score than single injection (group II) at 8 weeks. Conclusion TNC administered exogenously remained in the cartilage of knee joints for 1 week, and could decelerate articular cartilage degeneration in murine models of OA. We also showed that sequential administration of TNC was more effective than a single injection. TNC could be an important molecule for prevention of articular cartilage damage.

  16. Electromechanical Assessment of Human Knee Articular Cartilage with Compression-Induced Streaming Potentials.

    Science.gov (United States)

    Becher, Christoph; Ricklefs, Marcel; Willbold, Elmar; Hurschler, Christof; Abedian, Reza

    2016-01-01

    To assess the electromechanical properties of human knee articular cartilage with compression-induced streaming potentials for reliability among users and correlation with macroscopic and histological evaluation tools and sulfated glycosaminoglycan (sGAG) content. Streaming potentials are induced in cartilage in response to loading when mobile positive ions in the interstitial fluid temporarily move away from negatively charged proteoglycans. Streaming potential integrals (SPIs) were measured with an indentation probe on femoral condyles of 10 human knee specimens according to a standardized location scheme. Interobserver reliability was measured using an interclass correlation coefficient (ICC). The learning curves of 3 observers were evaluated by regression analysis. At each SPI measurement location the degradation level of the tissue was determined by means of the International Cartilage Repair Society (ICRS) score, Mankin score, and sGAG content. The computed ICC was 0.77 (0.70-0.83) indicating good to excellent linear agreement of SPI values among the 3 users. A significant positive linear correlation of the learning index values was observed for 2 of the 3 users. Statistically significant negative correlations between SPI and both ICRS and Mankin scores were observed (r = 0.502, P < 0.001, and r = 0.255, P = 0.02, respectively). No correlation was observed between SPI and sGAG content (r = 0.004, P = 0.973). SPI values may be used as a quantitative means of cartilage evaluation with sufficient reliability among users. Due to the significant learning curve, adequate training should be absolved before routine use of the technique.

  17. Neurological problems of famous musicians: the classical genre.

    Science.gov (United States)

    Newmark, Jonathan

    2009-08-01

    Neurological histories of great musicians allow for a unique perspective on music physiology. Bedrich Smetana's autobiographical string quartet ends with the musical equivalent of tinnitus in the fourth movement, rendering the youthful and passionate themes of earlier movements moot as the piece ends depicting his ultimately fatal disease, neurosyphilis. Dmitri Shostakovich survived the censorship of Joseph Stalin's apparatchiks but suffered a prolonged form of paralysis attributable to slowly progressive motor neuron disease, although the viola sonata he wrote on his deathbed has become standard repertoire. Glenn Gould was a hypochondriacal pianist with obsessive-compulsive disorder and suspected Asperger syndrome. Vissarion Shebalin and (Ira) Randall Thompson had strokes followed by aphasia without amusia. Domenico Scarlatti provides an example of how even great composers must alter their technical expectations depending upon the skills and body habitus of their chief patrons. The focal dystonia afflicting Leon Fleisher and Gary Graffman catalyzed the discipline of performing arts medicine.

  18. Teatri aastaauhindade laureaadid 2008

    Index Scriptorium Estoniae

    2008-01-01

    Tiit Ojasoo - lavastajaauhind, Silver Vahtre, Krista Tool ja Margus Vaigur - kunstniku auhind, Piret Laurimaa - naisnäitleja auhind, Üllar Saaremäe - meesnäitleja auhind, Tiina Tauraite - naiskõrvalosa auhind, Taavi Teplenkov - meeskõrvalosa auhind, Mart Koldits - sõnalavastuse eriauhind, Dmitri Bertman ja Mart Madiste - muusikalavastuse auhind, Vitali Nikolajev - muusikalavastuse eriauhind, Marina Kesler - balletilavastuse auhind, Oksana Titova - tantsulavastuse auhind, Ivika Sillar - kriitikaauhind, Külli Teetamm ja Tambet Tuisk - Ants Lauteri näitlejaauhind, Heli Veskus - Georg Otsa auhind, Finn Poulsen - Salme Reegi auhind, Elo Soode - Natalie Mei auhind, Aarne Üksküla - Priit Põldroosi auhind, Maimu Berg - Aleksander Kurtna auhind, Laura Peterson - Kristallkingakese auhind, Liina Laigu, Kaido Päästel ja Juhan Rumm - teatritöötaja auhind

  19. Eesti teatri aastaauhinnad 2007

    Index Scriptorium Estoniae

    2008-01-01

    Tiit Ojasoo - lavastajaauhind, Silver Vahtre, Krista Tool ja Margus Vaigur - kunstniku auhind, Piret Laurimaa - naisnäitleja auhind, Üllar Saaremäe - meesnäitleja auhind, Tiina Tauraite - naiskõrvalosa auhind, Taavi Teplenkov - meeskõrvalosa auhind, Mart Koldits - sõnalavastuse eriauhind, Dmitri Bertman ja Mart Madiste - muusikalavastuse auhind, Vitali Nikolajev - muusikalavastuse eriauhind, Marina Kesler - balletilavastuse auhind, Oksana Titova - tantsulavastuse auhind, Ivika Sillar - kriitikaauhind, Külli Teetamm ja Tambet Tuisk - Ants Lauteri näitlejaauhind, Heli Veskus - Georg Otsa auhind, Finn Poulsen - Salme Reegi auhind, Elo Soode - Natalie Mei auhind, Aarne Üksküla - Priit Põldroosi auhind, Maimu Berg - Aleksander Kurtna auhind, Laura Peterson - Kristallkingakese auhind, Liina Laigu, Kaido Päästel ja Juhan Rumm - teatritöötaja auhind

  20. Betting on better scientific literacy

    CERN Multimedia

    Daisy Yuhas

    Dmitry Zimin, founder of the Russian philanthropic foundation Dynasty, visited CERN on 23 October. Zimin, who is himself a scientist and businessman, founded Dynasty in order to support scientific education and a greater public understanding of scientific thinking. Zimin met the Bulletin to reflect on the experience and what had interested him about CERN. Zimin, who had read about and researched CERN before his visit, felt prepared for the physics at CERN but was greatly impressed by the collaborative “brainforce.” He observed that “The organization of all of these people is not less important as an achievement than all of the technical achievements, the collider, the experiments.” He was amazed at “how CERN has been able to organize such a grand collaboration of different people from different institutes of countries from all over the world.” At the core of the Dynasty Foundation’s ideals is the dissemination of scientific thought. Zimin ...

  1. Autour de Nikolaï Leskov et de William Shakespeare : Lady Macbeth sibérienne d'Andrzej Wajda

    OpenAIRE

    Géry, Catherine

    2016-01-01

    Lady Macbeth sibérienne d’Andrzej Wajda est un film qui joue constamment de codes plus ou moins conflictuels : cinéma et théâtre (William Shakespeare), mais aussi cinéma et opéra (Dmitri Chostakovitch), cinéma et conte oral (Nikolaï Leskov). Cultivant le dialogue entre les genres et les discours esthétiques, il est également au croisement des cultures et des époques. Dans ce chapitre, j’envisage la théâtralité du film de Wajda selon plusieurs de ses définitions possibles : la théâtralité comm...

  2. Experimental model to evaluate in vivo and in vitro cartilage MR imaging by means of histological analyses

    International Nuclear Information System (INIS)

    Bittersohl, B.; Mamisch, T.C.; Welsch, G.H.; Stratmann, J.; Forst, R.; Swoboda, B.; Bautz, W.; Rechenberg, B. von; Cavallaro, A.

    2009-01-01

    Objectives: Implementation of an experimental model to compare cartilage MR imaging by means of histological analyses. Material and methods: MRI was obtained from 4 patients expecting total knee replacement at 1.5 and/or 3 T prior surgery. The timeframe between pre-op MRI and knee replacement was within two days. Resected cartilage-bone samples were tagged with Ethi-pins to reproduce the histological cutting course. Pre-operative scanning at 1.5 T included following parameters for fast low angle shot (FLASH: TR/TE/FA = 33 ms/6 ms/30 deg., BW = 110 kHz, 120 mm x 120 mm FOV, 256 x 256 matrix, 0.65 mm slice-thickness) and double echo steady state (DESS: TR/TE/FA = 23.7 ms/6.9 ms/40 deg., BW = 130 kHz, 120 x 120 mm FOV, 256 x 256 matrix, 0.65 mm slice-thickness). At 3 T, scan parameters were: FLASH (TR/TE/FA = 12.2 ms/5.1 ms/10 deg., BW = 130 kHz, 170 x 170 mm FOV, 320 x 320, 0.5 mm slice-thickness) and DESS (TR/TE/FA = 15.6 ms/4.5 ms/25 deg., BW = 200 kHz, 135 mm x 150 mm FOV, 288 x 320 matrix, 0.5 mm slice-thickness). Imaging of the specimens was done the same day at 1.5 T. MRI (Noyes) and histological (Mankin) score scales were correlated using the paired t-test. Sensitivity and specificity for the detection of different grades of cartilage degeneration were assessed. Inter-reader and intra-reader reliability was determined using Kappa analysis. Results: Low correlation (sensitivity, specificity) was found for both sequences in normal to mild Mankin grades. Only moderate to severe changes were diagnosed with higher significance and specificity. The use of higher field-strengths was advantageous for both protocols with sensitivity values ranging from 13.6% to 93.3% (FLASH) and 20.5% to 96.2% (DESS). Kappa values ranged from 0.488 to 0.944. Conclusions: Correlating MR images with continuous histological slices was feasible by using three-dimensional imaging, multi-planar-reformat and marker pins. The capability of diagnosing early cartilage changes with high accuracy

  3. Cartilage collagen damage in hip osteoarthritis similar to that seen in knee osteoarthritis; a case-control study of relationship between collagen, glycosaminoglycan and cartilage swelling.

    Science.gov (United States)

    Hosseininia, Shahrzad; Lindberg, Lisbeth R; Dahlberg, Leif E

    2013-01-09

    It remains to be shown whether OA shares molecular similarities between different joints in humans. This study provides evidence for similarities in cartilage molecular damage in osteoarthritic (OA) joints. Articular cartilage from osteoarthritic hip joints were analysed and compared to non-OA controls regarding collagen, glycosaminoglycan and water content. Femoral heads from 16 osteoarthritic (OA) and 20 reference patients were obtained from hip replacement surgery due to OA and femoral neck fracture, respectively. Cartilage histological changes were assessed by Mankin grading and denatured collagen type II immunostaining and cartilage was extracted by α-chymotrypsin. Hydroxyproline and Alcian blue binding assays were used to measure collagen and glycosaminoglycan (GAG) content, respectively. Mankin and immunohistology scores were significantly higher in hip OA samples than in reference samples. Cartilage water content was 6% higher in OA samples than in references. 2.5 times more collagen was extracted from OA than from reference samples. There was a positive association between water content and percentage of extractable collagen pool (ECP) in both groups. The amounts of collagen per wet and dry weights did not differ statistically between OA and reference cartilage. % Extractable collagen was not related to collagen per dry weight in either group. However when collagen was expressed by wet weight there was a negative correlation between % extractable and collagen in OA cartilage. The amount of GAG per wet weight was similar in both groups but the amount of GAG per dry weight was higher in OA samples compared to reference samples, which suggests a capacity for GAG biosynthesis in hip OA cartilage. Neither of the studied parameters was related to age in either group. Increased collagen extractability and water content in human hip cartilage is associated with OA pathology and can be observed at early stages of the degenerative hip OA process. Our results

  4. Early detection of osteoarthritis in rabbits using MRI with a double-contrast agent.

    Science.gov (United States)

    Onishi, Okihiro; Ikoma, Kazuya; Kido, Masamitsu; Kabuto, Yukichi; Ueshima, Keiichiro; Matsuda, Ken-Ichi; Tanaka, Masaki; Kubo, Toshikazu

    2018-03-13

    Articular cartilage degeneration has been evaluated by magnetic resonance imaging (MRI). However, this method has several problems, including its time-consuming nature and the requirement of a high magnetic field or specialized hardware. The purpose of this study was to sequentially assess early degenerative changes in rabbit knee articular cartilage using MRI with a new double-contrast agent. We induced osteoarthritis (OA) in the right knee of rabbits by anterior cruciate ligament transection and partial medial meniscectomy. Proton density-weighted images and T 2 -calculated images were obtained before and after contrast agent injection into the knee. The signal intensity ratio (SIR) values on the proton density-weighted images were calculated by dividing the signal intensity of the articular cartilage by that of joint fluid. Six rabbits were examined using MRI at 2 (designated 2-w OA) and 4 weeks (4-w OA) after the operation. Histological examination was performed 4 weeks after the operation. One rabbit was histologically examined 2 weeks after the operation. The control consisted of six rabbits that were not subjected to the operation. The SIR values, T 2 values and the thicknesses of the cartilage of the 2-w OA, 4-w OA and the control before and after contrast agent injection were analyzed. The Mankin score and OARSI (Osteoarthritis Research Society International) score were used for the histological evaluation. Significant differences in the SIR and T 2 values of the medial and lateral condyles of the femur were found between the control and the 4-w OA only after contrast agent injection. No significant differences were found in the SIR and T 2 values before contrast agent injection between the control, the 2-w OA and 4-w OA. The thickness of the articular cartilage revealed no significant differences. In the histological assessment, the Mankin score and OARSI score sequentially increased from the control to the 4-w OA. We evaluated the SIR and T 2 values

  5. Therapeutic effect of an injectable sustained-release sinomenine hydrochloride and sodium hyaluronate compound in a rabbit model of osteoarthritis.

    Science.gov (United States)

    Liu, Wen-Guang; Ling, Pei-Xue; Lin, Xiu-Kun; Chen, Jian-Ying; Wang, Shao-Jin; Li, Peng; Wu, Xiao-Juan; Zhao, Dong-Mei; Liu, Sheng-Hou

    2012-07-01

    While intra-articular injection of sinomenine hydrochloride has a therapeutic effect on osteoarthritis, it has a short half-life, and is thermolabile and photolabile. The aim of this research was to evaluate the sustained-release of sinomenine hydrochloride from an injectable sinomenine hydrochloride and sodium hyaluronate compound (CSSSI) and its therapeutic effect in a rabbit model of osteoarthritis following intra-articular injection. An injectable compound consisting of 1% sodium hyaluronate and 2.5% sinomenine hydrochloride was prepared and kept as the experiment group, and 2.5% sinomenine hydrochloride was prepared and kept as the control group. The cumulative mass release was measured at different time points in each group in vitro. Sixty-five male Zelanian rabbits were randomly divided into five groups: 15 (30 knees) each for the control, sodium hyaluronate, sinomenine hydrochloride, and CSSSI groups respectively, and five (10 knees) for the modeling group. Papain was injected into both knees of each rabbit for model establishment. Subsequently, 0.2 ml of the corresponding drugs was injected into the articular cavities of the remaining experiment groups, while the control group was treated with 0.2 ml normal saline. All groups were treated once a week for 4 weeks. Seven days after the last treatment, knees were anatomized to perform pathological observations and Mankin's evaluation of the synovium. Four groups were compared using the SPSS 13.0 software package. In the in vitro sustained-release experiments, 90% of the drug was released in the experiment group 360 minutes following the injection. Comparison of the Mankin's evaluations of the four groups illustrated statistical discrepancies (P sodium hyaluronate/sinomenine hydrochloride groups, statistical significance was uniformly obtained. Moreover, sodium hyaluronate and sinomenine hydrochloride treatments showed significant improvement over the modeling control (P sodium hyaluronate vs. sinomenine

  6. Establishment of novel meniscal scaffold structures using polyglycolic and poly-l-lactic acids.

    Science.gov (United States)

    Murakami, Tomohiko; Otsuki, Shuhei; Nakagawa, Kosuke; Okamoto, Yoshinori; Inoue, Tae; Sakamoto, Yuki; Sato, Hideki; Neo, Masashi

    2017-08-01

    The purpose of this study was to evaluate various types of meniscus scaffolds that mimic the meniscus structure, and to establish a novel cell-free meniscus scaffold with polyglycolic acid or poly-l-lactic acid. Four types of scaffolds were implanted into Japanese white rabbits: poly-l-lactic acid sponge poly-l-lactic acid, PGA-coated PLLA sponge, PGA lamination, and film-coated PGA lamination. Samples were harvested at 8 and 12 weeks after implantation, and a compression stress test was performed. The meniscus size and Ishida scores were evaluated for regenerated tissue. Immunohistochemistry was analyzed by anti-type I, II and X collagen antibodies to investigate the structure of the regenerated tissue, and by anti-iNOS antibody to investigate the inflammatory tissue of the meniscus. The cell nuclei of lymphocytes and foreign body multinucleated giant cells were counted in hematoxylin and eosin staining. Modified Mankin scores for cartilage degeneration were used for assessment after Safranin-O/Fast Green staining. The biomechanical test showed that l- and film-coated PGA lamination exhibited greater strength than s- and PGA-coated PLLA sponge. At 12 weeks, the size of meniscus and the Ishida score in implanted film-coated PGA lamination were improved significantly compared with the defect groups. The type II collagen staining intensity in the PGA lamination lamination is significantly higher than the defect at eight weeks. The staining intensity of iNOS and number of lymphocytes significantly increased in sponge poly-l-lactic acid at eight weeks, and increased in p-PLLA at 12 weeks. Foreign body multinucleated giant cells in implantation groups appeared, especially at eight weeks. The Mankin score for film-coated PGA lamination was significantly lower than for the defect at 12 weeks. Novel meniscal scaffolds especially PGA should possess not only biological but also biomechanical functions. In conclusions, film-coated PGA lamination was the beneficial property

  7. Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs

    Directory of Open Access Journals (Sweden)

    Kuroki Keiichi

    2006-10-01

    Full Text Available Abstract Background Osteoarthritis (OA is a progressive and debilitating disease that often develops from a focal lesion and may take years to clinically manifest to a complete loss of joint structure and function. Currently, there is not a cure for OA, but early diagnosis and initiation of treatment may dramatically improve the prognosis and quality of life for affected individuals. This study was designed to determine the feasibility of analyzing changes in gene expression of articular cartilage using the Pond-Nuki model two weeks after ACL-transection in dogs, and to characterize the changes observed at this time point. Methods The ACL of four dogs was completely transected arthroscopically, and the contralateral limb was used as the non-operated control. After two weeks the dogs were euthanatized and tissues harvested from the tibial plateau and femoral condyles of both limbs. Two dogs were used for histologic analysis and Mankin scoring. From the other two dogs the surface of the femoral condyle and tibial plateau were divided into four regions each, and tissues were harvested from each region for biochemical (GAG and HP and gene expression analysis. Significant changes in gene expression were determined using REST-XL, and Mann-Whitney rank sum test was used to analyze biochemical data. Significance was set at (p Results Significant differences were not observed between ACL-X and control limbs for Mankin scores or GAG and HP tissue content. Further, damage to the tissue was not observed grossly by India ink staining. However, significant changes in gene expression were observed between ACL-X and control tissues from each region analyzed, and indicate that a unique regional gene expression profile for impending ACL-X induced joint pathology may be identified in future studies. Conclusion The data obtained from this study lend credence to the research approach and model for the characterization of OA, and the identification and validation of

  8. Successful Total Meniscus Reconstruction Using a Novel Fiber-Reinforced Scaffold: A 16- and 32-Week Study in an Ovine Model.

    Science.gov (United States)

    Merriam, Aaron R; Patel, Jay M; Culp, Brian M; Gatt, Charles J; Dunn, Michael G

    2015-10-01

    Meniscus injuries in the United States result in an estimated 850,000 surgical procedures each year. Although meniscectomies are the most commonly performed orthopaedic surgery, little advancement has been made in meniscus replacement and regeneration, and there is currently no total meniscus replacement device approved by the Food and Drug Administration. A novel fiber-reinforced meniscus scaffold can be used as a functional total meniscus replacement. Controlled laboratory study. A tyrosine-derived, polymer fiber-reinforced collagen sponge meniscus scaffold was evaluated mechanically (tensile and compressive testing) and histologically after 16 and 32 weeks of implantation in an ovine total meniscectomy model (N = 20; 16 implants plus 4 meniscectomies, divided equally over the 2 time periods). The extent of cartilage damage was also measured on tibial plateaus by use of toluidine blue surface staining and on femoral condyles by use of Mankin scores on histological slides. Scaffolds induced formation of neomeniscus tissue that remained intact and functional, with breaking loads approximating 250 N at both 16 and 32 weeks compared with 552 N for native menisci. Tensile stiffness values (99 and 74 N/mm at 16 and 32 weeks, respectively) were also comparable with those of the native meniscus (147 N/mm). The compressive modulus of the neomeniscus tissue (0.33 MPa at both 16 and 32 weeks) was significantly increased compared with unimplanted (time 0) scaffolds (0.15 MPa). There was histological evidence of extensive tissue ingrowth and extracellular matrix deposition, with immunohistochemical evidence of types I and II collagen. Based on significantly decreased surface damage scores as well as Mankin scores, the scaffold implants provided greater protection of articular cartilage compared with the untreated total meniscectomy. This novel fiber-reinforced meniscus scaffold can act as a functional meniscus replacement, with mechanical properties similar to those of the

  9. Attenuated synovial fluid ghrelin levels are linked with cartilage damage, meniscus injury, and clinical symptoms in patients with knee anterior cruciate ligament deficiency.

    Science.gov (United States)

    Zou, Yu-Cong; Chen, Liang-Hua; Ye, Yong-Liang; Yang, Guang-Gang; Mao, Zheng; Liu, Dan-Dan; Chen, Jun-Qi; Chen, Jing-Jie; Liu, Gang

    2016-12-01

    The meniscus injury and post-traumatic knee osteoarthritis (PTOA) following anterior cruciate ligament (ACL) lesions often cause great burdens to patients. Ghrelin, a recently identified 28-amino-acid peptide, has been shown to inhibit inflammation and perform as a growth factor for chondrocyte. This study was aimed at investigating ghrelin concentration in synovial fluid and its association with the degree of meniscus injury, articular degeneration, and clinical severity in patients suffering from anterior cruciate ligament (ACL) deficiency. 61 ACL deficiency patients admitted to our hospital were drafted in the current study. The Noyes scale and Mankin scores were used to assess articular cartilage damage arthroscopically and histopathologically, respectively. The Lysholm scores and International Knee Documentation Committee (IKDC) subjective scores were utilized to evaluate the clinical severity. The radiological severity of meniscus injury was assessed by MR imaging. Serum and synovial fluid ghrelin levels were determined using enzyme linked immunosorbent assay (ELISA). The cartilage degradation markers collagen type II C-telopeptide (CTX-II) and cartilage oligomeric matrix protein (COMP) in addition to inflammatory markers interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) were also examined. Receiver operating characteristic (ROC) curve was performed and the area under curve (AUC) was calculated to assess the diagnostic value of ghrelin levels for the prediction of the MRI grading for meniscus injury by comparing with other biomarkers. SF ghrelin levels were positively related to Lysholm and IKDC scores. PTOA patients with grade 3 showed significantly decreased levels of ghrelin in SF compared with those with grade 2. The ghrelin levels in SF were negatively related to MRI signal grades for meniscus injury. SF ghrelin levels were also inversely associated with Noyes scale and Mankin scores, and levels of inflammation markers IL-6, TNF-α, and

  10. Cartilage collagen damage in hip osteoarthritis similar to that seen in knee osteoarthritis; a case–control study of relationship between collagen, glycosaminoglycan and cartilage swelling

    Directory of Open Access Journals (Sweden)

    Hosseininia Shahrzad

    2013-01-01

    Full Text Available Abstract Background It remains to be shown whether OA shares molecular similarities between different joints in humans. This study provides evidence for similarities in cartilage molecular damage in osteoarthritic (OA joints. Methods Articular cartilage from osteoarthritic hip joints were analysed and compared to non-OA controls regarding collagen, glycosaminoglycan and water content. Femoral heads from 16 osteoarthritic (OA and 20 reference patients were obtained from hip replacement surgery due to OA and femoral neck fracture, respectively. Cartilage histological changes were assessed by Mankin grading and denatured collagen type II immunostaining and cartilage was extracted by α-chymotrypsin. Hydroxyproline and Alcian blue binding assays were used to measure collagen and glycosaminoglycan (GAG content, respectively. Results Mankin and immunohistology scores were significantly higher in hip OA samples than in reference samples. Cartilage water content was 6% higher in OA samples than in references. 2.5 times more collagen was extracted from OA than from reference samples. There was a positive association between water content and percentage of extractable collagen pool (ECP in both groups. The amounts of collagen per wet and dry weights did not differ statistically between OA and reference cartilage. % Extractable collagen was not related to collagen per dry weight in either group. However when collagen was expressed by wet weight there was a negative correlation between % extractable and collagen in OA cartilage. The amount of GAG per wet weight was similar in both groups but the amount of GAG per dry weight was higher in OA samples compared to reference samples, which suggests a capacity for GAG biosynthesis in hip OA cartilage. Neither of the studied parameters was related to age in either group. Conclusions Increased collagen extractability and water content in human hip cartilage is associated with OA pathology and can be observed at

  11. Indian Hedgehog in Synovial Fluid Is a Novel Marker for Early Cartilage Lesions in Human Knee Joint

    Science.gov (United States)

    Zhang, Congming; Wei, Xiaochun; Chen, Chongwei; Cao, Kun; Li, Yongping; Jiao, Qiang; Ding, Juan; Zhou, Jingming; Fleming, Braden C.; Chen, Qian; Shang, Xianwen; Wei, Lei

    2014-01-01

    To determine whether there is a correlation between the concentration of Indian hedgehog (Ihh) in synovial fluid (SF) and the severity of cartilage damage in the human knee joints, the knee cartilages from patients were classified using the Outer-bridge scoring system and graded using the Modified Mankin score. Expression of Ihh in cartilage and SF samples were analyzed with immunohistochemistry (IHC), western blot, and enzyme-linked immunosorbent assay (ELISA). Furthermore, we detected and compared Ihh protein levels in rat and mice cartilages between normal control and surgery-induced osteoarthritis (OA) group by IHC and fluorescence molecular tomography in vivo respectively. Ihh expression was increased 5.2-fold in OA cartilage, 3.1-fold in relative normal OA cartilage, and 1.71-fold in OA SF compared to normal control samples. The concentrations of Ihh in cartilage and SF samples was significantly increased in early-stage OA samples when compared to normal samples (r = 0.556; p Ihh protein was also an early event in the surgery-induced OA models. Increased Ihh is associated with the severity of OA cartilage damage. Elevated Ihh content in human knee joint synovial fluid correlates with early cartilage lesions. PMID:24786088

  12. Indian Hedgehog in Synovial Fluid Is a Novel Marker for Early Cartilage Lesions in Human Knee Joint

    Directory of Open Access Journals (Sweden)

    Congming Zhang

    2014-04-01

    Full Text Available To determine whether there is a correlation between the concentration of Indian hedgehog (Ihh in synovial fluid (SF and the severity of cartilage damage in the human knee joints, the knee cartilages from patients were classified using the Outer-bridge scoring system and graded using the Modified Mankin score. Expression of Ihh in cartilage and SF samples were analyzed with immunohistochemistry (IHC, western blot, and enzyme-linked immunosorbent assay (ELISA. Furthermore, we detected and compared Ihh protein levels in rat and mice cartilages between normal control and surgery-induced osteoarthritis (OA group by IHC and fluorescence molecular tomography in vivo respectively. Ihh expression was increased 5.2-fold in OA cartilage, 3.1-fold in relative normal OA cartilage, and 1.71-fold in OA SF compared to normal control samples. The concentrations of Ihh in cartilage and SF samples was significantly increased in early-stage OA samples when compared to normal samples (r = 0.556; p < 0.001; however, there were no significant differences between normal samples and late-stage OA samples. Up-regulation of Ihh protein was also an early event in the surgery-induced OA models. Increased Ihh is associated with the severity of OA cartilage damage. Elevated Ihh content in human knee joint synovial fluid correlates with early cartilage lesions.

  13. Experimentally induced cam impingement in the sheep hip.

    Science.gov (United States)

    Siebenrock, Klaus A; Fiechter, Ruth; Tannast, Moritz; Mamisch, Tallal C; von Rechenberg, Brigitte

    2013-04-01

    Sheep hips have a natural non-spherical femoral head similar to a cam-type deformity in human beings. By performing an intertrochanteric varus osteotomy, cam-type femoro-acetabular impingement (FAI) during flexion can be created. We tested the hypotheses that macroscopic lesions of the articular cartilage and an increased Mankin score (MS) can be reproduced by an experimentally induced cam-type FAI in this ovine in vivo model. Furthermore, we hypothesized that the MS increases with longer ambulatory periods. Sixteen sheep underwent unilateral intertrochanteric varus osteotomy of the hip with the non-operated hip as a control. Four sheep were sacrificed after 14, 22, 30, and 38-weeks postoperatively. We evaluated macroscopic chondrolabral alterations, and recorded the MS, based on histochemical staining, for each ambulatory period. A significantly higher prevalence of macroscopic chondrolabral lesions was found in the impingement zone of the operated hips. The MS was significantly higher in the acetabular/femoral cartilage of the operated hips. Furthermore, these scores increased as the length of the ambulatory period increased. Cam-type FAI can be induced in an ovine in vivo model. Localized chondrolabral degeneration of the hip, similar to that seen in humans (Tannast et al., Clin Orthop Relat Res 2008; 466: 273-280; Beck et al., J Bone Joint Surg Br 2005; 87: 1012-1018), can be reproduced. This experimental sheep model can be used to study cam-type FAI. Copyright © 2012 Orthopaedic Research Society.

  14. Effects of phototherapy on cartilage structure and inflammatory markers in an experimental model of osteoarthritis

    Science.gov (United States)

    Oliveira, Poliani; Santos, Anderson Amaro; Rodrigues, Tamara; Tim, Carla Roberta; Pinto, Karina Zambone; Magri, Angela Maria Paiva; Fernandes, Kelly Rossetti; Mattiello, Stela M.; Parizotto, Nivaldo Antonio; Anibal, Fernanda Freitas; Rennó, Ana Claudia Muniz

    2013-12-01

    The aim of this study was to evaluate the effects of laser phototherapy on the degenerative modifications on the articular cartilage after the anterior cruciate ligament transection (ACLT) in the knee of rats. Eighty male rats (Wistar) were distributed into four groups: intact control group (IG), injured control group (CG), injured laser treated group at 10 J/cm2 (L10), and injured laser treated group at 50 J/cm2 (L50). Animals were distributed into two subgroups, sacrificed in 5 and 8 weeks postsurgery. The ACLT was used to induce knee osteoarthritis in rats. After 2 weeks postsurgery, laser phototherapy initiated and it was performed for 15 and 30 sessions. The histological findings revealed that laser irradiation, especially at 10 J/cm2, modulated the progression of the degenerative process, showing a better cartilage structure and lower number of condrocytes compared to the other groups. Laser phototherapy was not able to decrease the degenerative process measured by Mankin score and prevent the increase of cartilage thickness related to the degenerative process. Moreover, it did not have any effect in the biomodulation of the expression of markers IL1β, tumor necrosis factor-α, and metalloprotein-13. Furthermore, laser irradiated animals, at 50 J/cm2 showed a lower amount of collagen type 1.

  15. Functional outcome measures in a surgical model of hip osteoarthritis in dogs.

    Science.gov (United States)

    Little, Dianne; Johnson, Stephen; Hash, Jonathan; Olson, Steven A; Estes, Bradley T; Moutos, Franklin T; Lascelles, B Duncan X; Guilak, Farshid

    2016-12-01

    The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis. The purpose of this study was to evaluate a surgical model of hip osteoarthritis in a large laboratory animal model and to evaluate functional and end-point outcome measures. Seven dogs were subjected to partial surgical debridement of cartilage from one femoral head. Pre- and postoperative pain and functional scores, gait analysis, radiographs, accelerometry, goniometry and limb circumference were evaluated through a 20-week recovery period, followed by histological evaluation of cartilage and synovium. Animals developed histological and radiographic evidence of osteoarthritis, which was correlated with measurable functional impairment. For example, Mankin scores in operated limbs were positively correlated to radiographic scores but negatively correlated to range of motion, limb circumference and 20-week peak vertical force. This study demonstrates that multiple relevant functional outcome measures can be used successfully in a large laboratory animal model of hip osteoarthritis. These measures could be used to evaluate relative efficacy of therapeutic interventions relevant to human clinical care.

  16. The Anti-Inflammatory Activity of Toonaciliatin K against Adjuvant Arthritis

    Directory of Open Access Journals (Sweden)

    HaiXing Gou

    2017-01-01

    Full Text Available Toonaciliatin K is a natural limonoid purified from the Toona ciliata Roem. var. ciliata (Meliaceae. This study is to reveal the inflammatory suppression effect of toonaciliatin K and further the intrinsic mechanism. Firstly, anti-inflammatory effect of toonaciliatin K was evaluated in lipopolysaccharide- (LPS- induced RAW264.7 cells. RT-PCR results indicated that the mRNA expressions of TNF-α, IL-6, and IL-1β were downregulated by toonaciliatin K. The toonaciliatin K inhibited TNF-α, IL-6, and IL-1β levels stimulated by LPS. Furthermore, LPS elicited the excess iNOS and COX-2 mRNA and protein production and toonaciliatin K attenuated the excess production. Western blot assay demonstrated that MAPK and NF-κB signaling pathways play critical roles in the toonaciliatin K’s anti-inflammatory activity. Secondly, toonaciliatin K inhibited carrageenan-induced paw edema in rats. Thirdly, toonaciliatin K alleviated the paw swelling and improved arthritis clinical scores in the adjuvant arthritis rats. Toonaciliatin K decreased the proinflammatory cytokines levels and Mankin scores in adjuvant arthritis rats. The HE staining, safranin O-fast green, and toluidine blue staining results demonstrated that toonaciliatin K alleviated the histological changes of paw, for example, pannus formation, focal loss of cartilage, bone erosion, and presence of extra-articular inflammation. Hence, toonaciliatin K is a promising agent for treatment of arthritis.

  17. Colored-noise-induced discontinuous transitions in symbiotic ecosystems

    Science.gov (United States)

    Mankin, Romi; Sauga, Ako; Ainsaar, Ain; Haljas, Astrid; Paunel, Kristiina

    2004-06-01

    A symbiotic ecosystem is studied by means of the Lotka-Volterra stochastic model, using the generalized Verhulst self-regulation. The effect of fluctuating environment on the carrying capacity of a population is taken into account as dichotomous noise. The study is a follow-up of our investigation of symbiotic ecosystems subjected to three-level (trichotomous) noise [R. Mankin, A. Ainsaar, A. Haljas, and E. Reiter, Phys. Rev. E 65, 051108 (2002)]. Relying on the mean-field theory, an exact self-consistency equation for stationary states is derived. In some cases the mean field exhibits hysteresis as a function of noise parameters. It is established that random interactions with the environment can cause discontinuous transitions. The dependence of the critical coupling strengths on the noise parameters is found and illustrated by phase diagrams. Predictions from the mean-field theory are compared with the results of numerical simulations. Our results provide a possible scenario for catastrophic shifts of population sizes observed in nature.

  18. Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu

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    Mesfin Yimam

    2017-01-01

    Full Text Available Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition from Morus alba, Scutellaria baicalensis, and Acacia catechu in maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA- induced rat OA disease model. Study lasted for 6 weeks. 59.6%, 64.6%, 70.7%, 69.9%, and 70.3% reductions in pain sensitivity were observed for rats treated with the composition from week 1 to week 5, respectively. Statistically significant improvements in articular cartilage matrix integrity (maintained at 57.1% versus MIA + vehicle treated rats were shown from the modified total Mankin score for animals treated with the composition. The composition showed a statistically significant reduction in uCTX-II level (54.1% reductions. The merit of combining these botanicals was also demonstrated in their synergistic analgesic activity. Therefore, the standardized blend of Morus alba, Scutellaria baicalensis, and Acacia catechu could potentially be considered as an alternative remedy from natural sources for the management of OA and/or its associated symptoms.

  19. Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles

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    Marta Anna Szychlinska

    2016-03-01

    Full Text Available Osteoarthritis is the most common human arthritis characterized by degeneration of articular cartilage. Several studies reported that levels of human cartilage glycoprotein chitinase 3-like-1 (CHI3L1 are known as a potential marker for the activation of chondrocytes and the progression of Osteoarthritis (OA, whereas lubricin appears to be chondroprotective. The aim of this study was to investigate the co-expression and co-localization of CHI3L1 and lubricin in normal and osteoarthritic rat articular cartilage to correlate their modified expression to a specific grade of OA. Samples of normal and osteoarthritic rat articular cartilage were analyzed by the Kellgren–Lawrence OA severity scores, the Kraus’ modified Mankin score and the Histopathology Osteoarthritis Research Society International (OARSI system for histomorphometric evaluations, and through CHI3L1 and lubricin gene expression, immunohistochemistry and double immuno-staining analysis. The immunoexpression and the mRNA levels of lubricin increased in normal cartilage and decreased in OA cartilage (normal vs. OA, p < 0.01. By contrast, the immunoexpression and the mRNA levels of CHI3L1 increased in OA cartilage and decreased in normal cartilage (normal vs. OA, p < 0.01. Our findings are consistent with reports suggesting that these two glycoproteins are functionally associated with the development of OA and in particular with grade 2/3 of OA, suggesting that in the future they could be helpful to stage the severity and progression of the disease.

  20. Prenatal ethanol exposure increases osteoarthritis susceptibility in female rat offspring by programming a low-functioning IGF-1 signaling pathway

    Science.gov (United States)

    Ni, Qubo; Tan, Yang; Zhang, Xianrong; Luo, Hanwen; Deng, Yu; Magdalou, Jacques; Chen, Liaobin; Wang, Hui

    2015-10-01

    Epidemiological evidence indicates that osteoarthritis (OA) and prenatal ethanol exposure (PEE) are both associated with low birth weight but possible causal interrelationships have not been investigated. To investigate the effects of PEE on the susceptibility to OA in adult rats that experienced intrauterine growth retardation (IUGR), and to explore potential intrauterine mechanisms, we established the rat model of IUGR by PEE and dexamethasone, and the female fetus and 24-week-old adult offspring subjected to strenuous running for 6 weeks were sacrificed. Knee joints were collected from fetuses and adult offspring for histochemistry, immunohistochemistry and qPCR assays. Histological analyses and the Mankin score revealed increased cartilage destruction and accelerated OA progression in adult offspring from the PEE group compared to the control group. Immunohistochemistry showed reduced expression of insulin-like growth factor-1 (IGF-1) signaling pathway components. Furthermore, fetuses in the PEE group experienced IUGR but exhibited a higher postnatal growth rate. The expression of many IGF-1 signaling components was downregulated, which coincided with reduced amounts of type II collagen in the epiphyseal cartilage of fetuses in the PEE group. These results suggest that PEE enhances the susceptibility to OA in female adult rat offspring by down-regulating IGF-1 signaling and retarding articular cartilage development.

  1. Decrease in the expression of the type 1 PTH/PTHrP receptor (PTH1R on chondrocytes in animals with osteoarthritis

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    Skwara Adrian

    2010-04-01

    Full Text Available Abstract Background To evaluate the expression of the type 1 PTH/PTHrP receptor (PTH1R on chondrocytes from hyaline cartilage over the course of osteoarthritis (OA. Methods In 12 NZW rabbits, the anterior cruciate ligament (ACL was resected to create anterior instability of the knee. In 12 control rabbits, only a sham operation, without resection of the ACL, was performed. Four animals from each group were killed at 3, 6, and 12 weeks. After opening the knee joint, OA was macroscopically graded and hyaline cartilage of the load-bearing area was evaluated histologically according to the Mankin scale and by immunostaining for PTH1R. Results There was a positive linear correlation between the time after surgery and the macroscopic and histologic OA scores. The scores in the control group were constant over the time course. Immunostaining showed significantly less expression of PTH1R in the experimental compared to the control group after 6 (P Conclusions The results show an in vivo decrease in the expression of PTH1R on chondrocytes over the time course of OA. Further studies are needed to evaluate whether new treatment approaches could evolve from this knowledge.

  2. Effect of Low-Intensity Pulsed Ultrasound on Joint Injury and Post-Traumatic Osteoarthritis: an Animal Study.

    Science.gov (United States)

    Zahoor, Talal; Mitchell, Reed; Bhasin, Priya; Guo, Yi; Paudel, Sharada; Schon, Lew; Zhang, Zijun

    2018-01-01

    This study investigated the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) in post-traumatic osteoarthritis (PTOA). Intra-articular fracture of the medial tibial plateau was surgically created in 30 rats. LIPUS was applied to the operated joints either for the first 2 wk (LIPUS 1-2 group) or in weeks 4 and 5 after intra-articular fracture (LIPUS 4-5 group). In controls, the operated knees were not treated with LIPUS (LIPUS 0 group). The rats were monitored with weekly gait analysis and euthanized at week 8. Among the altered gait parameters, the maximal and average paw print areas in the LIPUS 1-2 and LIPUS 4-5 groups, but not the LIPUS 0 group, had either reached baseline or significantly recovered (70%, p <0.05) by week 8. PTOA pathology in both the LIPUS 1-2 and LIPUS 4-5 groups was less severe than that in the LIPUS 0 group (Mankin score: 5.4 and 4.5 vs. 8.8, p <0.05). In conclusion, LIPUS treatment partially improved the gait of the affected limbs and reduced cartilage degeneration in PTOA. Copyright © 2018 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved.

  3. The colour of the solar corona and dust grains in it

    International Nuclear Information System (INIS)

    Ajmanov, A.K.; Nikolsky, G.M.

    1980-01-01

    The photometry of coronal negatives is carried out. The films were obtained at the March 7, 1970 and July 10, 1972 eclipses. A distribution of the coronal brightness in the red (635 mm), green (545 nm), and blue (455 nm) wavelength intervals up to distances of (6-7)Rsub(sun) is deduced (Figure 1). Colour indexes of the corona (the emission ratio red/blue-Csub(rb) and green/blue-Csub(gb)) have been obtained. We assume Csub(rb) = Csub(gb) = 1 in the inner corona ( = 1 μm. RED brightness is evaluated to be 4 x 10 -10 anti Bsub(sun). There is 1 grain of dust in the elementary volume with cross section of 1 cm 2 along the line of sight. The intensity of dust emission in wavelength interval 10 μm deduced by the authors is approximately 1 μ W cm -2 sm -1 . That is in agreement with Mankin et al. (1974) and Lena et al. (1974) observations. The whole dust mass of RED is -11 cm -3 . Determination of the colour of the solar corona have been made by a number of scientists (Tikhov, 1940, 1957; Allen, 1946; Blackwell, 1952; Michard, 1956; Sharonov, 1958; Nay et al. 1961). The corona colour was found to be somewhat redder than the Sun's. However this question is not finally settled to date. (orig.)

  4. Negative Outcomes of Poly(l-Lactic Acid) Fiber-Reinforced Scaffolds in an Ovine Total Meniscus Replacement Model.

    Science.gov (United States)

    Patel, Jay M; Merriam, Aaron R; Kohn, Joachim; Gatt, Charles J; Dunn, Michael G

    2016-09-01

    Our objective was to test the efficacy of collagen-hyaluronan scaffolds reinforced with poly(l-lactic acid) (PLLA) fibers in an ovine total meniscus replacement model. Scaffolds were implanted into 9 sheep (n = 1 at 8 weeks, n = 2 at 16 weeks, n = 3 at both 24, 32 weeks) following total medial meniscectomy. From 16 weeks on, explants were characterized by confined compression creep, histological, and biochemical analyses. Articular surfaces were observed macroscopically and damage was ranked histologically using the Mankin score. At sacrifice, three of the nine PLLA scaffolds had completely ruptured, and the intact scaffolds experienced progressive shape changes and severe narrowing in the body region at 16, 24, and 32 weeks. Aggregate compressive modulus and permeability did not improve with time. Histological and biochemical analyses showed significantly less extracellular matrix and less matrix organization compared to native tissue. Osteophytes, bone erosion, and cartilage damage were observed, increasing with time postimplantation. A buildup of lactic acid and/or the rapid loss of scaffold mechanical integrity due to PLLA degradation are probable causes for the joint abnormalities observed in this study. These results are in sharp contrast to those of our previous successful total meniscus replacement studies using polyarylate [p(DTD DD)] fiber-reinforced scaffolds. This suggests that PLLA fiber as produced in this study cannot be used as reinforcement for a meniscus replacement scaffold.

  5. Recycling of extracorporeally irradiated autograft for malignant bone tumors: long-term follow-up.

    Science.gov (United States)

    Kotb, Samir Z; Mostafa, Mohamed F

    2013-11-01

    This study was conducted to evaluate the long-term oncological and functional outcomes. Forty-two patients (29 men and 13 women) with primary malignant bone tumors were included in this study. The procedure consisted of wide en bloc resection, clearing the extraosseous soft tissue and medullary content, extracorporeal irradiation with a single dose of 50 Gy using linear accelerator, and reimplantation using suitable fixation devices. The mean survivor follow-up was 54 months (24-174 months). There were 32 (76.2%) patients continuously disease free, 7 (16.7%) died of disease, and 3 (7.1%) alive with disease. Local recurrence was encountered in 4 (9.5%) patients. Nonunion occurred at 3 (6.4%) osteotomy sites. Deep infection developed in 4 (9.5%) cases. There were 13 patients rated excellent, 17 good, 10 fair, and 2 failures according to the Mankin scoring system. The mean ratings of the Musculoskeletal Tumor Society score and the Toronto Extremity Salvage Score were 77 and 81, respectively. The long-term oncological and functional results are encouraging and suggest that extracorporeal irradiation and reimplantation can be a long-lasting biological reconstructive technique in properly selected patients.

  6. Cartilage damage involving extrusion of mineralisable matrix from the articular calcified cartilage and subchondral bone

    Directory of Open Access Journals (Sweden)

    A Boyde

    2011-05-01

    Full Text Available Arthropathy of the distal articular surfaces of the third metacarpal (Mc3 and metatarsal (Mt3 bones in the Thoroughbred racehorse (Tb is a natural model of repetitive overload arthrosis. We describe a novel pathology that affects the articular calcified cartilage (ACC and subchondral bone (SCB and which is associated with hyaline articular cartilage degeneration. Parasagittal slices cut from the palmar quadrant of the distal condyles of the left Mc3/Mt3 of 39 trained Tbs euthanased for welfare reasons were imaged by point projection microradiography, and backscattered electron (BSE scanning electron microscopy (SEM, light microscopy, and confocal scanning light microscopy. Mechanical properties were studied by nanoindentation. Data on the horses' training and racing career were also collected. Highly mineralised projections were observed extending from cracks in the ACC mineralising front into the hyaline articular cartilage (HAC up to two-thirds the thickness of the HAC, and were associated with focal HAC surface fibrillation directly overlying their site. Nanoindentation identified this extruded matrix to be stiffer than any other mineralised phase in the specimen by a factor of two. The presence of projections was associated with a higher cartilage Mankin histology score (P < 0.02 and increased amounts of gross cartilage loss pathologically on the condyle (P < 0.02. Presence of projections was not significantly associated with: total number of racing seasons, age of horse, amount of earnings, number of days in training, total distance galloped in career, or presence of wear lines.

  7. Hyaline cartilage degenerates after autologous osteochondral transplantation.

    Science.gov (United States)

    Tibesku, C O; Szuwart, T; Kleffner, T O; Schlegel, P M; Jahn, U R; Van Aken, H; Fuchs, S

    2004-11-01

    Autologous osteochondral grafting is a well-established clinical procedure to treat focal cartilage defects in patients, although basic research on this topic remains sparse. The aim of the current study was to evaluate (1) histological changes of transplanted hyaline cartilage of osteochondral grafts and (2) the tissue that connects the transplanted cartilage with the adjacent cartilage in a sheep model. Both knee joints of four sheep were opened surgically and osteochondral grafts were harvested and simultaneously transplanted to the contralateral femoral condyle. The animals were sacrificed after three months and the received knee joints were evaluated histologically. Histological evaluation showed a complete ingrowth of the osseous part of the osteochondral grafts. A healing or ingrowth at the level of the cartilage could not be observed. Histological evaluation of the transplanted grafts according to Mankin revealed significantly more and more severe signs of degeneration than the adjacent cartilage, such as cloning of chondrocytes and irregularities of the articular surface. We found no connecting tissue between the transplanted and the adjacent cartilage and histological signs of degeneration of the transplanted hyaline cartilage. In the light of these findings, long-term results of autologous osteochondral grafts in human beings have to be followed critically.

  8. Glycosaminoglycan loss from cartilage after anterior cruciate ligament rupture: influence of time since rupture and chondral injury Perda de glicosaminoglicanas da cartilagem após ruptura do ligamento cruzado anterior: influência do tempo de ruptura e da lesão condral

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    SMG Mattiello-Rosa

    2008-02-01

    Full Text Available OBJECTIVE: To quantify the concentration of sulfated glycosaminoglycans (GAGs concentration in the synovial fluid (SF of knees with chronic anterior cruciate ligament (ACL rupture and to identify possible associations between GAG concentration in SF and the time elapsed since rupture and degree of chondral injury. METHOD: Fourteen adult male subjects with total unilateral ACL rupture, which had occurred between 5 and 144 months earlier, were assessed. All subjects underwent joint aspiration; it was possible to collect SF from ten individuals. The samples were quantified to determine the GAG concentration using dimethylmethylene blue (DMMB staining. The degree of chondral injury was macroscopically evaluated using the modified Mankin histological scale. Spearman correlation test (OBJETIVO: Quantificar a concentração de glicosaminoglicanas sulfatadas (GAGs no líquido sinovial (LS de joelhos com ruptura crônica do ligamento cruzado anterior (LCA e identificar uma possível correlação entre a concentração de GAGs no LS e o tempo pós-ruptura e grau de lesão condral. MÉTODOS: Foram avaliados 14 indivíduos adultos do sexo masculino com ruptura total unilateral do LCA, ocorrida entre cinco a 144 meses. Todos os sujeitos foram puncionados, sendo possível a coleta de LS em dez indivíduos. As amostras foram quantificadas para determinar a concentração de GAGs usando a coloração azul de dimetilmetileno, método descrito por Farndale21. O grau de lesão condral foi macroscopicamente avaliado pela escala histológica de Mankin modificada por Messner14. As correlações entre concentração de GAGs e lesão condral foram feitas pelo teste de correlação de Sperman (p< 0,05 e a concentração de GAGs e tempo pós-ruptura pelo teste de correlação de Pearson (p< 0,05. RESULTADOS: Concentração de GAGs no LS apresentou variação média de 73,84 ± 40,75µg/mL, sendo o tempo médio pós-ruptura de 40,4 + 40,3 meses. Não houve correla

  9. Meniscectomia parcial como modelo experimental de osteoartrite em coelhos e efeito protetor do difosfato de cloroquina Partial meniscectomy as an experimental model of osteoarthritis in rabbits and protector effect of chloroquine diphosphate

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    Ana Paula P. Velosa

    2007-12-01

    Full Text Available OBJETIVO: Estabelecer as alterações morfológicas e o remodelamento do tecido cartilaginoso na progressão da osteoartrite (OA experimental para estudar o efeito do difosfato de cloroquina na cartilagem osteoartrítica. MÉTODOS: A osteoartrite experimental foi induzida em coelhos por meio de meniscectomia parcial. Para analisar a evolução da doença experimental foram estudados três grupos de dez animais, sacrificados a 3, 14 e 22 semanas de indução da doença. Para avaliar o efeito do difosfato de cloroquina um grupo de animais (n = 6 foi tratado preventivamente com 3 mg/kg ao dia, iniciados um mês antes da indução da osteoartrite, e mantidos até o sacrifício (22 semanas. Realizou-se análise histológica das articulações (H&E, tricrômico de Masson e imunofluorescência para colágeno dos tipos I, II e XI. A intensidade da agressão articular foi quantificada pelo escore de Mankin. RESULTADOS: O modelo experimental reproduziu todas as alterações morfológicas observadas na osteoartrite humana. Animais que receberam difosfato de cloroquina não desenvolveram lesões histológicas observadas na OA. Neste grupo houve significante preservação da estrutura da cartilagem articular (p OBJECTIVE: The aim of this study was to develop an experimental model of osteoarthritis (OA that could reproduce morphologic alterations viewed in this disease and to study the effect of chloroquine diphosphate on cartilage remodeling. METHODS: osteoarthritis was induced in rabbits by performing partial meniscectomy. To establish the experimental disease evolution, three groups of ten animals were sacrificed at 3, 14, 22 weeks after disease induction. To evaluate the effect of chloroquine diphosfate in OA progression, a group of six animals was treated preventively with 3 mg/kg/day, started one month prior to osteoarthritis induction and kept until the day of sacrifice (22 weeks. Histopathological (Masson trychrome, H&E, biochemical and

  10. Downregulation of miR-221-3p contributes to IL-1β-induced cartilage degradation by directly targeting the SDF1/CXCR4 signaling pathway.

    Science.gov (United States)

    Zheng, Xin; Zhao, Feng-Chao; Pang, Yong; Li, Dong-Ya; Yao, Sheng-Cheng; Sun, Shao-Song; Guo, Kai-Jin

    2017-06-01

    Osteoarthritis (OA) is characterized by degradation of chondrocyte extracellular matrix (ECM). Accumulating evidence suggests that microRNAs (miRNAs) are associated with OA, but little is known of their function in chondrocyte ECM degradation. The objective of this study was to investigate the expression and function of miRNAs in OA. miRNA expression profile was determined in OA cartilage tissues and controls, employing Solexa sequencing and reverse transcription quantitative PCR (RT-qPCR). According to a modified Mankin scale, cartilage degradation was evaluated. Functional analysis of the miRNAs on chondrocyte ECM degradation was performed after miRNA transfection and IL-1β treatment. Luciferase reporter assays and western blotting were employed to determine miRNA targets. Expression of miR-221-3p was downregulated in OA cartilage tissues, which was significantly correlated with a modified Mankin scale. Through gain-of-function and loss-of-function studies, miR-221-3p was shown to significantly affect matrix synthesis gene expression and chondrocyte proliferation and apoptosis. Using SW1353 and C28I2 cells, SDF1 was identified as a target of miR-221-3p. SDF1 overexpression resulted in increased expression of catabolic genes such as MMP-13 and ADAMTS-5 in response to IL-1β, but these effects were moderated by miR-221-3p. SDF1 treatment antagonized this effect, while knockdown of SDF1 by shSDF1 induced inhibitory effects on the expression of CXCR4 and its main target genes, similar to miR-221-3p. The results indicate that upregulation of miR-221-3p could prevent IL-1β-induced ECM degradation in chondrocytes. Targeting the SDF1/CXCR4 signaling pathway may be used as a therapeutic approach for OA. miR-221-3p is downregulated in human cartilage tissues. miR-221-3p levels are associated with cartilage degeneration grade. miR-221-3p upregulation prevents IL-1β-induced ECM degradation in chondrocytes. Protection of ECM degradation by miR-223-3p occurs via SDF1/CXCR4

  11. Relação entre a lesão condral e o pico de torque após reconstrução do ligamento cruzado anterior do joelho: estudo de casos Relationship between chondral lesion and peak torque following anterior cruciate ligament reconstruction of the knee: case study

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    RF Traete

    2007-06-01

    Full Text Available CONTEXTUALIZAÇÃO: A associação entre lesão do ligamento cruzado anterior (LCA e desenvolvimento de osteoartrite (OA secundária tem sido objeto de vários estudos. A lesão ligamentar predispõe a lesões da cartilagem articular, influenciando, assim, o controle motor e o pico de torque. OBJETIVO: Avaliar a influência do grau de lesão condral no pico de torque da musculatura anterior e posterior da coxa após lesão e reconstrução do LCA. MÉTODO: Seis sujeitos do sexo masculino com lesão total e unilateral do LCA foram avaliados pré-cirurgia (24 horas antes da cirurgia e pós-cirurgia em dois momentos distintos, 4,66 ± 1,03 e 15,83 ± 2,63 meses, respectivamente. As avaliações isocinéticas foram realizadas no modo concêntrico de flexão e extensão do joelho, nas velocidades de 60º/s e 180º/s, em que foram a analisadas as variáveis PT dos isquiotibiais (PTI, PT do quadríceps (PTQ e a relação entre eles (I/Q. A escala histológica de Mankin modificada foi utilizada para avaliar o grau macroscópico de lesão condral. O teste estatístico ANOVA (pCONTEXT: The association between anterior cruciate ligament (ACL injury and the development of secondary osteoarthritis has been the subject of several studies. Ligament injury predisposes joint cartilage lesions, thus influencing motor control and peak torque. OBJECTIVE: To evaluate the influence of the degree of chondral lesion on peak torque of the anterior and posterior musculature of the thigh following ACL injury and reconstruction. METHOD: Six male subjects with total unilateral ACL injury were evaluated 24 hours before surgery and at two times after surgery (4.66 ± 1.03 and 15.83 ± 2.63 months, respectively. Isokinetic evaluations of knee flexion and extension were made in concentric mode, at velocities of 60º/s and 180º/s, and the variables of hamstring peak torque (HPT and quadriceps peak torque (QPT and hamstring/quadriceps ratio (H/Q were analyzed. The modified

  12. Articulation of Native Cartilage Against Different Femoral Component Materials. Oxidized Zirconium Damages Cartilage Less Than Cobalt-Chrome.

    Science.gov (United States)

    Vanlommel, Jan; De Corte, Ronny; Luyckx, Jean Philippe; Anderson, Melissa; Labey, Luc; Bellemans, Johan

    2017-01-01

    Oxidized zirconium (OxZr) is produced by thermally driven oxidization creating an oxidized surface with the properties of a ceramic at the top of the Zr metal substrate. OxZr is much harder and has a lower coefficient of friction than cobalt-chrome (CoCr), both leading to better wear characteristics. We evaluated and compared damage to the cartilage of porcine patella plugs, articulating against OxZr vs CoCr. Our hypothesis was that, owing to its better wear properties, OxZr would damage cartilage less than CoCr. If this is true, OxZr might be a better material for the femoral component during total knee arthroplasty if the patella is not resurfaced. Twenty-one plugs from porcine patellae were prepared and tested in a reciprocating pin-on-disk machine while lubricated with bovine serum and under a constant load. Three different configurations were tested: cartilage-cartilage as the control group, cartilage-OxZr, and cartilage-CoCr. Macroscopic appearance, cartilage thickness, and the modified Mankin score were evaluated after 400,000 wear cycles. The control group showed statistically significant less damage than plugs articulating against both other materials. Cartilage plugs articulating against OxZr were statistically significantly less damaged than those articulating against CoCr. Although replacing cartilage by an implant always leads to deterioration of the cartilage counterface, OxZr results in less damage than CoCr. The use of OxZr might thus be preferable to CoCr in case of total knee arthroplasty without patella resurfacing. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Making star teams out of star players.

    Science.gov (United States)

    Mankins, Michael; Bird, Alan; Root, James

    2013-01-01

    Top talent is an invaluable asset: In highly specialized or creative work, for instance, "A" players are likely to be six times as productive as "B" players. So when your company has a crucial strategic project, why not multiply all that firepower and have a team of your best performers tackle it? Yet many companies hesitate to do this, believing that all-star teams don't work: Big egos will get in the way. The stars won't be able to work with one another. They'll drive the team Leader crazy. Mankins, Bird, and Root of Bain & Company believe it's time to set aside that thinking. They have seen all-star teams do extraordinary work. But there is a right way and a wrong way to organize them. Before you can even begin to assemble such a team, you need to have the right talent management practices, so you hire and develop the best people and know what they're capable of. You have to give the team appropriate incentives and leaders and support staffers who are stars in their own right. And projects that are ill-defined or small scale are not for all-star teams. Use them only for critical missions, and make sure their objectives are clear. Even with the right setup, things can still go wrong. The wise executive will take steps to manage egos, prune non-team-players, and prevent average coworkers from feeling completely undervalued. She will also invest a lot of time in choosing the right team Leader and will ask members for lots of feedback to monitor how that leader is doing.

  14. Preliminary histopathological study of intra-articular injection of a novel highly cross-linked hyaluronic acid in a rabbit model of knee osteoarthritis.

    Science.gov (United States)

    Iannitti, Tommaso; Elhensheri, Mohamed; Bingöl, Ali O; Palmieri, Beniamino

    2013-04-01

    Osteoarthritis is a degenerative joint disease mostly occurring in the knee and commonly seen in middle-aged and elderly adults. Intra-articular injection of hyaluronic acid has been widely used for treatment of knee osteoarthritis. The aim of this study was to evaluate the efficacy of intra-articular injection of a novel highly cross-linked hyaluronic acid, alone or in combination with ropivacaine hydrochloride and triamcinolone acetonide, on knee articular cartilage in a rabbit model of collagenase-induced knee osteoarthritis. After induction of experimental osteoarthritis by intra-articular injection of collagenase, adult New Zealand white rabbits (n = 12) were divided into 3 groups. Group 1 (control group) received 0.3 ml phosphate buffered saline into the right knee joint. Group 2 received 0.3 ml cross-linked hyaluronic acid (33 mg/ml) into the right knee joint. Group 3 received a mixture of 0.15 ml cross-linked hyaluronic acid (33 mg/ml), 0.05 ml ropivacaine hydrochloride 1 % and 0.1 ml triamcinolone acetonide (10 mg/ml) into the right knee joint. Intra-articular injections were given 4 weeks after first collagenase injection and were administered once a week for 3 weeks. Gross pathology and histological evaluation of rabbits' knee joints were performed after 16 weeks following initial collagenase injection. Histological analysis of sections of right knee joints at lesion sites showed a significant decrease in Mankin's score in groups treated with hyaluronic acid alone or in combination with ropivacaine hydrochloride and triamcinolone acetonide versus control group (p hyaluronic acid, alone or in combination with ropivacaine hydrochloride and triamcinolone acetonide, produces a significant improvement in knee articular cartilage degeneration in a rabbit model of collagenase-induced osteoarthritis.

  15. A comparison between platelet-rich plasma (PRP and hyaluronate acid on the healing of cartilage defects.

    Directory of Open Access Journals (Sweden)

    Ji Liu

    Full Text Available Platelet-rich plasma (PRP has offered great promise for the treatment of cartilage degradation, and has been proved to have positive effects on the restoration of cartilage lesions. But no comparative work has been done between PRP and hyaluronate acid (HA concerning their restoring effect on cartilage defect, especially by means of animal experiments and histologic assessments. The purpose of the study was to compare the therapeutic effects of P-PRP and HA on osteoarthritis in rabbit knees. Thirty rabbits were used to establish the animal models by creating a cartilage defect of 5 mm in diameter on the condyles of the femurs, and were randomly divided into three groups: the P-PRP group, HA group and the control group. Then each group was treated with P-PRP, HA or saline solution, respectively. Six and twelve weeks later the rabbits were sacrificed and the samples were collected. The platelet number, the concentrations of growth factors of P-PRP and whole blood, and the IL-1β concentration in the joint fluid were investigated, and the histological assessment of the cartilage were performed according to Mankin's scoring system. Micro-CT was also used to evaluate the restoration of subchondral bone. The platelet concentration in P-PRP is 6.8 fold of that in the whole blood. The IL-1β level in the P-PRP group was lower than in the HA group (p<0.01 and in the control group (p<0.01. The restoration of the defected cartilage as well as the subchondral bone was better in the P-PRP group than in the HA group or the control group (P<0.05. Our data showed that P-PRP is better than HA in promoting the restoration of the cartilage and alleviating the arthritis caused by cartilage damage.

  16. Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice.

    Science.gov (United States)

    Zhang, C; Chiu, K Y; Chan, B P M; Li, T; Wen, C; Xu, A; Yan, C H

    2018-06-01

    Adipokines play roles in the pathogenesis of osteoarthritis (OA). Fatty acid binding protein 4 (FABP4) is a novel adipokine that is closely associated with obesity and metabolic diseases. The aim of this study was to discover the potential role of FABP4 in OA. Seventy-two FABP4 knockout mice (KO) in C57BL/6N background and wild-type littermates (WT) (male, 6-week-old) were fed with a high-fat diet (HFD, 60% calorie) or standard diet (STD, 11.6% calorie) for 3 months, 6 months and 9 months (n = 6 each). In the parallel study, forty-eight 6-week-old male WT mice were fed with HFD or STD, and simultaneously treated with daily oral gavage of selective FABP4 inhibitor BMS309403 (15 mg/kg/d) or vehicle for 4 months and 6 months (n = 6 each). Serum FABP4 and cartilage oligomeric matrix protein (COMP) concentration was quantified. Histological assessment of knee OA and micro-CT analysis of subchondral bone were performed. HFD induced obesity in mice. After 3 months and 6 months of HFD, KO mice showed alleviated cartilage degradation and synovitis, with significantly lower COMP, modified Mankin OA score, and MMP-13/ADAMTS4 expression. After 6 months and 9 months of HFD, KO mice showed less osteophyte formation and subchondral bone sclerosis. Chronic treatment of BMS309403 for 4 months and 6 months significantly alleviated cartilage degradation, but had no effects on the subchondral bone. Knocking out or pharmaceutical inhibition of FABP4 did not have significant effects on lean mice fed with STD. Knocking out or pharmaceutical inhibition of FABP4 alleviates OA induced by HFD in mice. Copyright © 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  17. Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis.

    Science.gov (United States)

    Lin, Neng-Yu; Distler, Alfiya; Beyer, Christian; Philipi-Schöbinger, Ariella; Breda, Silvia; Dees, Clara; Stock, Michael; Tomcik, Michal; Niemeier, Andreas; Dell'Accio, Francesco; Gelse, Kolja; Mattson, Mark P; Schett, Georg; Distler, Jörg Hw

    2016-11-01

    Notch ligands and receptors have recently been shown to be differentially expressed in osteoarthritis (OA). We aim to further elucidate the functional role of Notch signalling in OA using Notch1 antisense transgenic (Notch1 AS) mice. Notch and hedgehog signalling were analysed by real-time PCR and immunohistochemistry. Notch-1 AS mice were employed as a model of impaired Notch signalling in vivo. Experimental OA was induced by destabilisation of the medial meniscus (DMM). The extent of cartilage destruction and osteophyte formation was analysed by safranin-O staining with subsequent assessment of the Osteoarthritis Research Society International (OARSI) and Mankin scores and µCT scanning. Collagen X staining was used as a marker of chondrocyte hypertrophy. The role of hairy/enhancer of split 1 (Hes-1) was investigated with knockdown and overexpression experiments. Notch signalling was activated in human and murine OA with increased expression of Jagged1, Notch-1, accumulation of the Notch intracellular domain 1 and increased transcription of Hes-1. Notch1 AS mice showed exacerbated OA with increases in OARSI scores, osteophyte formation, increased subchondral bone plate density, collagen X and osteocalcin expression and elevated levels of Epas1 and ADAM-TS5 mRNA. Inhibition of the Notch pathway induced activation of hedgehog signalling with induction of Gli-1 and Gli-2 and increased transcription of hedgehog target genes. The regulatory effects of Notch signalling on Gli-expression were mimicked by Hes-1. Inhibition of Notch signalling activates hedgehog signalling, enhances chondrocyte hypertrophy and exacerbates experimental OA including osteophyte formation. These data suggest that the activation of the Notch pathway may limit aberrant hedgehog signalling in OA. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  18. Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep.

    Science.gov (United States)

    Cake, M A; Read, R A; Corfield, G; Daniel, A; Burkhardt, D; Smith, M M; Little, C B

    2013-01-01

    Meniscectomy (MX) of sheep induces a well-established animal model of human osteoarthritis (OA). This study compared the clinical (lameness) and pathological outcomes of unilateral, complete medial MX vs two less traumatic and more easily performed meniscal destabilisation procedures. Four-year old wethers (n = 6/group) underwent sham operation, cranial pole release (CPR), mid-body transection (MBT) or total MX of the medial meniscus. Joints were assessed for gross pathology (cartilage erosion and osteophytes), histomorphometry, two histopathology scoring methods (modified Mankin-type and Pritzker score), and immunohistology for ADAMTS- and MMP-cleaved neoepitopes, at 12 weeks post-op. Ground reaction forces (GRFs) were determined by force plate in a subset (n = 4/group) at baseline, 2.5, 8, and 12 weeks post-op. Gross pathology scores of operated groups differed significantly from sham animals (P osteophyte formation. Similarly, histopathology scores were significantly elevated vs sham but did not differ between operated groups at P subchondral sclerosis, suggesting some residual biomechanical effect from the destabilised but intact meniscus. Few significant differences were noted between operated groups in force plate analyses, though gait abnormalities appeared to be least in CPR sheep, and most persistent (>12 weeks) in MBT animals. The well-validated ovine MX model and the simpler meniscal destabilisation procedures resulted in broadly similar joint pathology and lameness. Meniscal CPR or MBT, as easier and more clinically relevant procedures, may represent preferred models for the induction of OA and evaluation of potential disease-modifying therapies. Copyright © 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  19. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.

    Science.gov (United States)

    Hayami, Tadashi; Pickarski, Maureen; Zhuo, Ya; Wesolowski, Gregg A; Rodan, Gideon A; Duong, Le T

    2006-02-01

    Osteoarthritis (OA) is a chronic joint disease characterized by cartilage destruction, subchondral bone sclerosis, and osteophyte formation. Subchondral bone stiffness has been proposed to initiate and/or contribute to cartilage deterioration in OA. The purpose of this study was to characterize subchondral bone remodeling, cartilage damage, and osteophytosis during the disease progression in two models of surgically induced OA. Rat knee joints were subjected either to anterior cruciate ligament transection (ACLT) alone or in combination with resection of medial menisci (ACLT + MMx). Histopathological changes in the surgical joints were compared with sham at 1, 2, 4, 6, and 10 weeks post-surgery. Using a modified Mankin scoring system, we demonstrate that articular cartilage damage occurs within 2 weeks post-surgery in both surgical models. Detectable cartilage surface damage and proteoglycan loss were observed as early as 1 week post-surgery. These were followed by the increases in vascular invasion into cartilage, in loss of chondrocyte number and in cell clustering. Histomorphometric analysis revealed subchondral bone loss in both models within 2 weeks post-surgery followed by significant increases in subchondral bone volume relative to sham up to 10 weeks post-surgery. Incidence of osteophyte formation was optimally observed in ACLT joints at 10 weeks and in ACLT + MMx joints at 6 weeks post-surgery. In summary, the two surgically induced rat OA models share many characteristics seen in human and other animal models of OA, including progressive articular cartilage degradation, subchondral bone sclerosis, and osteophyte formation. Moreover, increased subchondral bone resorption is associated with early development of cartilage lesions, which precedes significant cartilage thinning and subchondral bone sclerosis. Together, these findings support a role for bone remodeling in OA pathogenesis and suggest that these rat models are suitable for evaluating bone

  20. Histopathological subgroups in knee osteoarthritis.

    Science.gov (United States)

    Wyatt, L A; Moreton, B J; Mapp, P I; Wilson, D; Hill, R; Ferguson, E; Scammell, B E; Walsh, D A

    2017-01-01

    Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated measures of OA histopathological features. Medial tibial plateaux and synovium were from 343 post-mortem (PM) and 143 OA arthroplasty donations. A 'chondropathy/osteophyte' group (n = 217) was classified as PM cases with osteophytes or macroscopic medial tibiofemoral chondropathy lesions ≥grade 3 to represent pre-surgical (early) OA. 'Non-arthritic' controls (n = 48) were identified from the remaining PM cases. Mankin histopathological scores were subjected to Rasch analysis and supplemented with histopathological scores for subchondral bone marrow replacement and synovitis. Item weightings were derived by principle components analysis (PCA). Histopathological subgroups were sought using latent class analysis (LCA). Chondropathy, synovitis and osteochondral pathology were each associated with OA at arthroplasty, but each was also identified in some 'non-arthritic' controls. Tidemark breaching in the chondropathy/osteophyte group was greater than in non-arthritic controls. Three histopathological subgroups were identified, characterised as 'mild OA', or 'severe OA' with mild or moderate/severe synovitis. Presence and severity of synovitis helps define distinct histopathological OA subgroups. The absence of a discrete 'normal' subgroup indicates a pathological continuum between normality and OA status. Identifying specific pathological processes and their clinical correlates in OA subgroups has potential to accelerate the development of more effective therapies. Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  1. Whole meniscus regeneration using polymer scaffolds loaded with fibrochondrocytes

    Directory of Open Access Journals (Sweden)

    LU Hua-ding

    2012-02-01

    Full Text Available 【Abstract】Objective: To study the feasibility of regenerating a whole menisci using poly- (3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV scaffolds loaded with meniscal cells in rabbits undergoing total meniscectomy, and to explore its protective effect on cartilage degeneration. Methods: A solvent casting and particulate leaching technique was employed to fabricate biodegradable PHBV scaffolds into a meniscal shape. The proliferated meniscal cells were seeded onto the polymer scaffolds, transplanted into rabbit knee joints whose lateral menisci had been removed. Eight to 18 weeks after transplantation, the regenerated neomenisci were evaluated by gross and histological observations. Cartilage degeneration was assessed by Mankin score. Results: Eighteen weeks after transplantation, the implants formed neomenisci. Hematoxylin and eosin (HE staining of the neomenisci sections revealed regeneration of fibrocartilage. Type I collagen in the neomenisci was also proved similar to normal meniscal tissue by immunohistochemical analysis and Sirius scarlet trinitrophenol staining. Articular cartilage degeneration was observed 8 weeks after implantation. It was less severe as compared with that in total meniscectomy controls and no further degeneration was observed at 18 weeks. At that time, the regenerated neomenisci strongly resembled normal meniscal fibrocartilage in gross and histological appearance, and its mechani- cal property was also close to that of normal meniscus. Conclusions: The present study demonstrates the feasibility of tissue-engineering a whole meniscal structure in total meniscectomy rabbit models using biodegradable PHBV scaffolds together with cultured allogeneic meniscal cells. Cartilage degeneration is decreased. But long-term in vivo investigations on the histological structure and cartilage degeneration of the neomenisci regenerated by this method are still necessary to determine the clinical potential of this tissue

  2. Effects of phosphorylatable short peptide-conjugated chitosan-mediated IL-1Ra and igf-1 gene transfer on articular cartilage defects in rabbits.

    Directory of Open Access Journals (Sweden)

    Ronglan Zhao

    Full Text Available Previously, we reported an improvement in the transfection efficiency of the plasmid DNA-chitosan (pDNA/CS complex by the utilization of phosphorylatable short peptide-conjugated chitosan (pSP-CS. In this study, we investigated the effects of pSP-CS-mediated gene transfection of interleukin-1 receptor antagonist protein (IL-1Ra combined with insulin-like growth factor-1 (IGF-1 in rabbit chondrocytes and in a rabbit model of cartilage defects. pBudCE4.1-IL-1Ra+igf-1, pBudCE4.1-IL-1Ra and pBudCE4.1-igf-1 were constructed and combined with pSP-CS to form pDNA/pSP-CS complexes. These complexes were transfected into rabbit primary chondrocytes or injected into the joint cavity. Seven weeks after treatment, all rabbits were sacrificed and analyzed. High levels of IL-1Ra and igf-1 expression were detected both in the cell culture supernatant and in the synovial fluid. In vitro, the transgenic complexes caused significant proliferation of chondrocytes, promotion of glycosaminoglycan (GAG and collagen II synthesis, and inhibition of chondrocyte apoptosis and nitric oxide (NO synthesis. In vivo, the exogenous genes resulted in increased collagen II synthesis and reduced NO and GAG concentrations in the synovial fluid; histological studies revealed that pDNA/pSP-CS treatment resulted in varying degrees of hyaline-like cartilage repair and Mankin score decrease. The co-expression of both genes produced greater effects than each single gene alone both in vitro and in vivo. The results suggest that pSP-CS is a good candidate for use in gene therapy for the treatment of cartilage defects and that igf-1 and IL-1Ra co-expression produces promising biologic effects on cartilage defects.

  3. Turning great strategy into great performance.

    Science.gov (United States)

    Mankins, Michael C; Steele, Richard

    2005-01-01

    Despite the enormous time and energy that goes into strategy development, many companies have little to show for their efforts. Indeed, research by the consultancy Marakon Associates suggests that companies on average deliver only 63% of the financial performance their strategies promise. In this article, Michael Mankins and Richard Steele of Marakon present the findings of this research. They draw on their experience with high-performing companies like Barclays, Cisco, Dow Chemical, 3M, and Roche to establish some basic rules for setting and delivering strategy: Keep it simple, make it concrete. Avoid long, drawn-out descriptions of lofty goals and instead stick to clear language describing what your company will and won't do. Debate assumptions, not forecasts. Create cross-functional teams drawn from strategy, marketing, and finance to ensure the assumptions underlying your long-term plans reflect both the real economics of your company's markets and its actual performance relative to competitors. Use a rigorous analytic framework. Ensure that the dialogue between the corporate center and the business units about market trends and assumptions is conducted within a rigorous framework, such as that of "profit pools". Discuss resource deployments early. Create more realistic forecasts and more executable plans by discussing up front the level and timing of critical deployments. Clearly identify priorities. Prioritize tactics so that employees have a clear sense of where to direct their efforts. Continuously monitor performance. Track resource deployment and results against plan, using continuous feedback to reset assumptions and reallocate resources. Reward and develop execution capabilities. Motivate and develop staff. Following these rules strictly can help narrow the strategy-to-performance gap.

  4. Modification of osteoarthritis in the guinea pig with pulsed low-intensity ultrasound treatment.

    Science.gov (United States)

    Gurkan, I; Ranganathan, A; Yang, X; Horton, W E; Todman, M; Huckle, J; Pleshko, N; Spencer, R G

    2010-05-01

    The Hartley guinea pig develops articular cartilage degeneration similar to that seen in idiopathic human osteoarthritis (OA). We investigated whether the application of pulsed low-intensity ultrasound (PLIUS) to the Hartley guinea pig joint would prevent or attenuate the progression of this degenerative process. Treatment of male Hartley guinea pigs was initiated at the onset of degeneration (8 weeks of age) to assess the ability of PLIUS to prevent OA, or at a later age (12 months) to assess the degree to which PLIUS acted to attenuate the progression of established disease. PLIUS (30 mW/cm(2)) was applied to stifle joints for 20 min/day over periods ranging from 3 to 10 months, with contralateral limbs serving as controls. Joint cartilage histology was graded according to a modified Mankin scale to evaluate treatment effect. Immunohistochemical staining for interleukin-1 receptor antagonist (IL-1ra), matrix metalloproteinase (MMP)-3, MMP-13, and transforming growth factor (TGF)-beta1 was performed on the cartilage to evaluate patterns of expression of these proteins. PLIUS did not fully prevent cartilage degeneration in the prevention groups, but diminished the severity of the disease, with the treated joints showing markedly decreased surface irregularities and a much smaller degree of loss of matrix staining as compared to controls. PLIUS also attenuated disease progression in the groups with established disease, although to a somewhat lesser extent as compared to the prevention groups. Immunohistochemical staining demonstrated a markedly decreased degree of TGF-beta1 production in the PLIUS-treated joints. This indicates less active endogenous repair, consistent with the marked reduction in cartilage degradation. PLIUS exhibits the ability to attenuate the progression of cartilage degeneration in an animal model of idiopathic human OA. The effect was greater in the treatment of early, rather than established, degeneration. Published by Elsevier Ltd.

  5. Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes

    International Nuclear Information System (INIS)

    Jimenez, P.A.; Glasson, S.S.; Trubetskoy, O.V.; Haimes, H.B.

    1997-01-01

    Dunkin Hartley guinea pigs develop spontaneous, age-related osteoarthritis (OA) of the knee and other joints. Histologic changes are observed beginning at 3 months of age. Disease severity increases with age, and at 18 months moderate to severe OA is observed. A study was undertaken to assess the morphologic and biochemical changes of 22-month-old animals, and to compare them with values in 2-month-old guinea pigs. Biochemical indices characteristic of OA, from tibial cartilage, indicated an increase in proteoglycan content from 283 +/- 2 micrograms/mg (mean +/- SEM) at 2 months of age to 365 +/- 6 micrograms/mg at 22 months. Collagen concentration in cartilage decreased from 364 +/- 2 micrograms/ at 2 months to 223 +/- 3 micrograms/mg at 22 months. Proteoglycan fragments found in synovial fluid measured 4.6 +/- 1 micrograms/ml at 2 months and increased to 37 +/- 2 micrograms/ml at 22 months. Radiographic changes observed at 22 months included marginal osteophytes of the tibia and femur, sclerosis of the subchondral bone of the tibial plateau, femoral condyle cysts, and calcification of the collateral ligaments. Histologic evaluation revealed severe OA, with a Mankin score of 10.7 +/- 0.5 in 22-month-old animals. In contrast, 2-month-old animals had no histologic or radiographically detectable lesions. The results of the study reported here indicate that the lesions observed in this model are similar to those of human OA. Spontaneous development of OA in guinea pig is amenable to the study of the pathogenesis of OA and to the evaluation of potential disease-modifying agents

  6. Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates.

    Science.gov (United States)

    Kondo, Shimpei; Muneta, Takeshi; Nakagawa, Yusuke; Koga, Hideyuki; Watanabe, Toshifumi; Tsuji, Kunikazu; Sotome, Shinichi; Okawa, Atsushi; Kiuchi, Shinji; Ono, Hideo; Mizuno, Mitsuru; Sekiya, Ichiro

    2017-06-01

    Transplantation of aggregates of synovial mesenchymal stem cells (MSCs) enhanced meniscus regeneration in rats. Anatomy and biological properties of the meniscus depend on animal species. To apply this technique clinically, it is valuable to investigate the use of animals genetically close to humans. We investigated whether transplantation of aggregates of autologous synovial MSCs promoted meniscal regeneration in aged primates. Chynomolgus primates between 12 and 13 years old were used. After the anterior halves of the medial menisci in both knees were removed, an average of 14 aggregates consisting of 250,000 synovial MSCs were transplanted onto the meniscus defect. No aggregates were transplanted to the opposite knee for the control. Meniscus and articular cartilage were analyzed macroscopically, histologically, and by MRI T1rho mapping at 8 (n = 3) and 16 weeks (n = 4). The medial meniscus was larger and the modified Pauli's histological score for the regenerated meniscus was better in the MSC group than in the control group in each primate at 8 and 16 weeks. Mankin's score for the medial femoral condyle cartilage was better in the MSC group than in the control group in all primates at 16 weeks. T1rho value for both the regenerated meniscus and adjacent articular cartilage in the MSC group was closer to the normal meniscus than in the control group in all primates at 16 weeks. Transplantation of aggregates of autologous synovial MSCs promoted meniscus regeneration and delayed progression of degeneration of articular cartilage in aged primates. This is the first report dealing with meniscus regeneration in primates. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1274-1282, 2017. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  7. The effect of high-energy extracorporeal shock waves on hyaline cartilage of adult rats in vivo.

    Science.gov (United States)

    Mayer-Wagner, Susanne; Ernst, Judith; Maier, Markus; Chiquet, Matthias; Joos, Helga; Müller, Peter E; Jansson, Volkmar; Sievers, Birte; Hausdorf, Jörg

    2010-08-01

    The aim of this study was to determine if extracorporeal shock wave therapy (ESWT) in vivo affects the structural integrity of articular cartilage. A single bout of ESWT (1500 shock waves of 0.5 mJ/mm(2)) was applied to femoral heads of 18 adult Sprague-Dawley rats. Two sham-treated animals served as controls. Cartilage of each femoral head was harvested at 1, 4, or 10 weeks after ESWT (n = 6 per treatment group) and scored on safranin-O-stained sections. Expression of tenascin-C and chitinase 3-like protein 1 (Chi3L1) was analyzed by immunohistochemistry. Quantitative real-time polymerase chain reaction (PCR) was used to examine collagen (II)alpha(1) (COL2A1) expression and chondrocyte morphology was investigated by transmission electron microscopy no changes in Mankin scores were observed after ESWT. Positive immunostaining for tenascin-C and Chi3L1 was found up to 10 weeks after ESWT in experimental but not in control cartilage. COL2A1 mRNA was increased in samples 1 and 4 weeks after ESWT. Alterations found on the ultrastructural level showed expansion of the rough-surfaced endoplasmatic reticulum, detachment of the cell membrane and necrotic chondrocytes. Extracorporeal shock waves caused alterations of hyaline cartilage on a molecular and ultrastructural level that were distinctly different from control. Similar changes were described before in the very early phase of osteoarthritis (OA). High-energy ESWT might therefore cause degenerative changes in hyaline cartilage as they are found in initial OA. Copyright 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  8. Editorial

    Directory of Open Access Journals (Sweden)

    Zinchenko, Yury P.

    2013-06-01

    Full Text Available The educational reform is Russia is in full swing, so the section of Psychology of education and learning is the most widely presented in the current issue. The international collective of authors Frédéric Yvon, Ludmila A. Chaiguerova and Denise Shelley Newnham considers different interpretations of the works of Lev Vygotsky — famous psychologist and methodologist. The authors suggest original ways of incorporating Vygotsky’s ideas into the modern educational system. Dmitry A. Podolskiy presents his study of value hierarchy among students and adolescence in the article “Multimethod approach to measuring values in a school context: exploring the association between Congruence — Discrepancy Index (CODI and task commitment”. In the article “The role of reflection and reflexivity in the development of student’s abilities” Vladimir D. Shadrikov explores the role of reflection in the educational process. The group of authors headed by Nikolay E. Veraksa state that dialectical thinking is a specific line of cognitive development in children and adults and proves this statement by the empirical data (“The structural dialectical approach in psychology problematic and research results”.

  9. Theory and Experiment on Radiative Shocks

    Science.gov (United States)

    Drake, R. Paul

    2005-07-01

    The current generation of high-energy-density research facilities has enabled the beginnings of experimental studies of radiation hydrodynamic systems, common in astrophysics but difficult to produce in the laboratory. Radiative shock experiments specifically have been a topic of increasing effort in recent years. Our group and collaborators [1] have emphasized the radiographic observation of structure in radiative shocks. These shocks have been produced on the Omega laser by driving a Be piston through Xenon at velocities above 100 km/s. The talk will summarize these experiments and their results. Interpreting these and other experiments is hampered by the limited range of assumptions used in published theories, and by the limitations in readily available simulation tools. This has motivated an examination of radiative shock theory [2]. The talk will summarize the key issues and present results for specific cases. [ 1 ] Gail Glendinning, Ted Perry, Bruce Remington, Jim Knauer, Tom Boehly, and other members of the NLUF Experimental Astrophysics Team. Publications: Reighard et al., Phys. Rev. Lett. submitted; Leibrandt, et al., Ap J., in press, Reighard et al., IFSA 03 Proceedings, Amer. Nucl. Soc. (2004). [2] Useful discussions with Dmitri Ryutov and Serge Bouquet. Supported by the NNSA programs via DOE Grants DE-FG52-03NA00064 and DE FG53 2005 NA26014

  10. Gazprom, Russia's weapon; Gazprom, l'arme de la Russie

    Energy Technology Data Exchange (ETDEWEB)

    Paniouchkine, V.; Zigar, M

    2008-07-01

    World number one producer of natural gas, Russia owns a third of the proven reserves. Gazprom company, under the control of the government and with a capital close to Microsoft's or Exxon Mobil's one, exploits this fabulous richness. Some highlights of its recent history show the dimension of the stakes: on January 1, 2006, Russia interrupts its gas supplies towards Ukraine. The immediate consequence is a voltage drop in Italy and France: the European Union is dependent at 26% of the Russian gas, Finland at 100%, France at 25%.. In May 2008, Dmitri Medvedev, president of Gazprom's supervisory board becomes the President of the Russian Federations and in August 2008, Russia seizes the opportunity of the Georgian conflict to solve the problem of the gas paths in the Caspian area. Several anecdotes are presented in this book which aim at demonstrating the tight links between the history of Gazprom, who aspires to become one of the very first World companies, and the foreign policy of Russia. (J.S.)

  11. Human security paradigms and economic crisis in first year of the North Caucasus Federal District

    Directory of Open Access Journals (Sweden)

    Tiago Ferreira Lopes

    2013-04-01

    Full Text Available The decrease in insecurity in the North Caucasus during the first eight years of the 21st century was achieved with the help of federal money used to amnesty soldiers and to pacify ethnic leaders' ambitions. But circumstances changed after Dmitry Kozak's announcement that the federal budget for the entire region would decrease significantly. As all the republics in the North Caucasus are dependent on federal aid of no less than 50% (in Ingushetia, Chechnya and Dagestan dependence is superior to 80%, such cut represented a politically potential danger. The main goal of the article is to present a deeper understanding of the potential link between the international and regional economic dynamics and the current acceleration of social disruption in the North Caucasus region. The paper explains how ethno-political and transition studies can benefit from the inclusion of the economic dimension into the analysis, and so it clarifies the importance of a bi-level analysis using two concepts: economic society and economic security. The paper employs the concepts of economic security and economic society to perform a richer and innovative analysis.

  12. Gazprom, Russia's weapon

    International Nuclear Information System (INIS)

    Paniouchkine, V.; Zigar, M.

    2008-01-01

    World number one producer of natural gas, Russia owns a third of the proven reserves. Gazprom company, under the control of the government and with a capital close to Microsoft's or Exxon Mobil's one, exploits this fabulous richness. Some highlights of its recent history show the dimension of the stakes: on January 1, 2006, Russia interrupts its gas supplies towards Ukraine. The immediate consequence is a voltage drop in Italy and France: the European Union is dependent at 26% of the Russian gas, Finland at 100%, France at 25%.. In May 2008, Dmitri Medvedev, president of Gazprom's supervisory board becomes the President of the Russian Federations and in August 2008, Russia seizes the opportunity of the Georgian conflict to solve the problem of the gas paths in the Caspian area. Several anecdotes are presented in this book which aim at demonstrating the tight links between the history of Gazprom, who aspires to become one of the very first World companies, and the foreign policy of Russia. (J.S.)

  13. Altered but Not Silenced: How Shostakovich Retained His Voice as an Artist despite the Demands of a Dictator

    Directory of Open Access Journals (Sweden)

    Hope R. Strayer

    2013-12-01

    Full Text Available Can music that is regulated and restrained by a dictator still be inspired? This question reveals ideology concerning how music should be created and valued. Does outside control restrict artistic integrity and autonomy? Not all composers have been free to write whatever their soul demands. People in authority have held power and control over artistic processes. Dmitri Shostakovich was a Russian composer whose work was subjected to the tastes of a tyrannical ruler and Communist party. Though Shostakovich did not compose in an environment that fostered musical exploration, his work should not be mourned but celebrated. Shostakovich was not a victim, but a victor of his music by the way he composed in the midst of the threat of denouncement. Though Shostakovich wrote music to follow the demands of others, the music was still his by the very fact that he created it; he brought it into existence and highlighted it with nuances of his being and personality as he produced each work. This research examines three critical pieces of Shostakovich’s canon to ascertain whether controlled art subjected to the whims, preferences, and objectives of others can still be inspired. Though a composer might be told what to say, it is he who chooses how to word a phrase. Shostakovich’s output, particularly the first symphony, his opera Lady Macbeth of the Mtsensk District, and fifth symphony exemplify that restrained and restricted music does not necessitate a sacrifice in artistic integrity; it can be inspired, celebrated, and worthy of study.

  14. The Ukraine Crisis Reflections in the Speeches of USA and Russian Political Leaders

    Directory of Open Access Journals (Sweden)

    Unikaitė-Jakuntavičienė Ingrida

    2017-10-01

    Full Text Available This paper focuses on the rhetoric of USA and Russian political leaders during the Ukraine crisis by analyzing changes appearing in their speeches during the different stages of the crisis. The goal of the analysis is to investigate the speeches delivered by political leaders of the United States and Russia, being important actors in the Ukraine crisis, by identifying both countries’ attitudes to one another, further intentions regarding the management of the crisis and changes of topics in each stage. The speeches of the following most influential politicians in foreign policy formation in the USA and Russia are analyzed: President Barack Obama, Secretary of State John Kerry and Vice President Joe Biden, President Vladimir Putin, Russian Foreign Minister Sergey Lavrov and Prime Minister of Russia Dmitry Medvedev. The speeches were collected from the official websites of U.S. and Russian government institutions. The analysis revealed that from the beginning of the crisis the main tool in the Ukraine crisis was rhetoric. Western parties began to take real actions only later: sanctions on Russia were imposed, international organizations started to play more active role, ceasefire agreements were signed. In terms of communications strategies used by both countries, the USA rhetoric and its communication strategy as well as Russian leaders were using a combination of proactive and reactive strategies.

  15. Experiments and simulations of flux rope dynamics in a plasma

    Science.gov (United States)

    Intrator, Thomas; Abbate, Sara; Ryutov, Dmitri

    2005-10-01

    The behavior of flux ropes is a key issue in solar, space and astrophysics. For instance, magnetic fields and currents on the Sun are sheared and twisted as they store energy, experience an as yet unidentified instability, open into interplanetary space, eject the plasma trapped in them, and cause a flare. The Reconnection Scaling Experiment (RSX) provides a simple means to systematically characterize the linear and non-linear evolution of driven, dissipative, unstable plasma-current filaments. Topology evolves in three dimensions, supports multiple modes, and can bifurcate to quasi-helical equilibria. The ultimate saturation to a nonlinear force and energy balance is the link to a spectrum of relaxation processes. RSX has adjustable energy density β1 to β 1, non-negligible equilibrium plasma flows, driven steady-state scenarios, and adjustable line tying at boundaries. We will show magnetic structure of a kinking, rotating single line tied column, magnetic reconnection between two flux ropes, and pictures of three braided flux ropes. We use computed simulation movies to bridge the gap between the solar physics scales and experimental data with computational modeling. In collaboration with Ivo Furno, Tsitsi Madziwa-Nussinovm Giovanni Lapenta, Adam Light, Los Alamos National Laboratory; Sara Abbate, Torino Polytecnico; and Dmitri Ryutov, Lawrence Livermore National Laboratory.

  16. Gallium--A smart metal

    Science.gov (United States)

    Foley, Nora; Jaskula, Brian W.

    2013-01-01

    Gallium is a soft, silvery metallic element with an atomic number of 31 and the chemical symbol Ga. The French chemist Paul-Emile Lecoq de Boisbaudran discovered gallium in sphalerite (a zinc-sulfide mineral) in 1875 using spectroscopy. He named the element "gallia" after his native land of France (formerly Gaul; in Latin, Gallia). The existence of gallium had been predicted in 1871 by Dmitri Mendeleev, the Russian chemist who published the first periodic table of the elements. Mendeleev noted a gap in his table and named the missing element "eka-aluminum" because he determined that its location was one place away from aluminum in the table. Mendeleev thought that the missing element (gallium) would be very much like aluminum in its chemical properties, and he was right. Solid gallium has a low melting temperature (~29 degrees Celsius, or °C) and an unusually high boiling point (~2,204 °C). Because of these properties, the earliest uses of gallium were in high-temperature thermometers and in designing metal alloys that melt easily. The development of a gallium-based direct band-gap semiconductor in the 1960s led to what is now one of the most well-known applications for gallium-based products--the manufacture of smartphones and data-centric networks.

  17. Stačiatikybės literatūros teologija: idėjos ir problemika | The theology of orthodox literature: ideas and problems

    Directory of Open Access Journals (Sweden)

    Gediminas Mikelaitis

    2012-01-01

    Full Text Available The articles presents an overview of the first post- Soviet attempts by the Russian literature scholars to consider the links between the ideas of the Ortho­doxy and literature. Attempts are put, besides defin­ing the Christian stratum of the Russian culture, to establish the methodology of the research. The ar­ticle highlights the unique character of the theology of the Orthodox literature, mainly anchored to the ideas of the Russian religious philosophy reflected in the works of the Russian thinkers and writers as Vladimir Solovyov, Nikolai Berdyaev, Dmitri Mer­ezhkovski, Fyodor Dostoyevsky, Andrei Bely and others. The article discusses the theologemes char­acteristic of the Orthodox literature: the depiction of Sophia, theurgic parameter, the ontological character of creation, performativeness, religious anthropol­ogy of Dostoyevsky. The uniqueness of the relation­ship between the Orthodoxy and literature is defined by demonstrating its link with religious philosophy, the aesthetic parameter of the existence, the role of religious ideas in literature, and the significance of theurgic aesthetics.

  18. Exoplanet Yield Estimation for Decadal Study Concepts using EXOSIMS

    Science.gov (United States)

    Morgan, Rhonda; Lowrance, Patrick; Savransky, Dmitry; Garrett, Daniel

    2016-01-01

    The anticipated upcoming large mission study concepts for the direct imaging of exo-earths present an exciting opportunity for exoplanet discovery and characterization. While these telescope concepts would also be capable of conducting a broad range of astrophysical investigations, the most difficult technology challenges are driven by the requirements for imaging exo-earths. The exoplanet science yield for these mission concepts will drive design trades and mission concept comparisons.To assist in these trade studies, the Exoplanet Exploration Program Office (ExEP) is developing a yield estimation tool that emphasizes transparency and consistent comparison of various design concepts. The tool will provide a parametric estimate of science yield of various mission concepts using contrast curves from physics-based model codes and Monte Carlo simulations of design reference missions using realistic constraints, such as solar avoidance angles, the observatory orbit, propulsion limitations of star shades, the accessibility of candidate targets, local and background zodiacal light levels, and background confusion by stars and galaxies. The python tool utilizes Dmitry Savransky's EXOSIMS (Exoplanet Open-Source Imaging Mission Simulator) design reference mission simulator that is being developed for the WFIRST Preliminary Science program. ExEP is extending and validating the tool for future mission concepts under consideration for the upcoming 2020 decadal review. We present a validation plan and preliminary yield results for a point design.

  19. Ühistegevuse alus - ühised väärtused / Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Vabariigi Presidendi kõne soome-ugri rahvaste 5. maailmakongressil Hantõ-Mansiiskis 28. juunil 2008. Vt. ka juhtkiri lk. 2: Kuningas Toomas Hendrik I. Eesti Päevaleht suhtub kriitiliselt president T. H. Ilvese demonstratiivsesse saalist väljamarssimisse Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatshovi sõnavõtu ajal. Lisatud karikatuur president T. H. Ilvesest ja Venemaa presidendist Dmitri Medvedevist. Ilmunud ka: Virumaa Teataja 1. juuli 2008, lk. 11, pealk.: Ühistegevuse alus on ühised väärtused (lüh.); Meie Kodu 16. juuli 2008, lk. 2, pealk.: Ilves rääkis euroopalike väärtuste, keelekaitse tähtsusest; Eesti Elu 4. juuli 2008, lk. 2, pealk.: Vabariigi President soome-ugri rahvaste 5. maailmakongressil Hantõ-Mansiiskis 28. juunil 2008 (lüh.); ingl. k. Vaba Eesti Sõna 24. juuli 2008, lk. 12, pealk.: European values are also useful east of the Urals

  20. Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder

    Directory of Open Access Journals (Sweden)

    Zastrozhin MS

    2017-07-01

    Full Text Available Mikhail Sergeevich Zastrozhin,1,2 Vadim Markovich Brodyansky,3 Valentin Yurievich Skryabin,4 Elena Anatolievna Grishina,5 Dmitry Vladimirovich Ivashchenko,5 Kristina Anatolievna Ryzhikova,5 Ludmila Mikhaylovna Savchenko,1 Alexander Olegovich Kibitov,3 Evgeny Alekseevich Bryun,1,4 Dmitry Alekseevich Sychev6 1Department of Addictology, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russia; 2Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Center for the Prevention of Dependent Behavior, Moscow, Russia; 3Federal Medical Research Centre of Psychiatry and Addictology, Laboratory of Molecular Genetics, Moscow, Russia; 4Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Department of Addictology, Moscow, Russia; 5Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Research Centre, Moscow, Russia; 6Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Department of Clinical Pharmacology and Therapy, Moscow, Russia Background: Antipsychotic action of haloperidol is due to blockade of D2 receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D2 receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these receptors and associated structures (catechol-O-methyltransferase [COMT], glycine transporter and gene encoding the density of D2 receptors on the neuronal membrane are described.Objective: The objectives of this study were to evaluate the correlation between DRD2, SLC6A3 (DAT and COMT genetic polymorphisms and to investigate their effect on the development of adverse drug reactions in patients with alcohol-use disorder who received haloperidol.Patients and methods: The study

  1. “Through the Letter Sent with my Envoys to Kiev” St. Dimitry`s of Rostov Contacts with Kiev and Chernigov in 1701–1709

    Directory of Open Access Journals (Sweden)

    Krylov Aleksei

    2016-10-01

    Full Text Available The article examines st. Dimitry’s of Rostov contacts with Kiev and Chernigov in 1701–1709. Dimitry’s correspondence is vast, but addressees of the most of the known letters are Dmitry’s Moscow friend and Great Russian hierarchs. Problem of st. Dimitry’s contacts with his Little Russian acquaintances still remain obscure. This article deals with the information of st. Dimitry of Rostov correspondence with addressees in Kiev and Chernigov and the circumstances of Dimitry’s visit to Chernigov in 1704. In time of his episcopal service st. Dimitry exchanged letters with Josaph Krokowski, archimandrit of Kievan Lauras and future metropolitan of Kiev. Letters were sent with agents of both hierarchs. This correspondence was devoted to the publication of the “Lives of the Saints” in the Lavra’s typography. There are no evedencies of st. Dimitry writing letteres to members of Chernigov clergy in 1701–1709, although st. John Maximovich archbishop of Chernigov sent his new books to Dimitry of Rostov. However in february of 1704st. Dmitry undertook a journey to Chernigov that left almost no traces in sources. The main evidence is record of Pachomios of Roman, a Moldavian ascetic, about himself meeting Rostov metropolitan in Chernigov in 1704. This trip was an exeptional event and could be connected with the demise of Parthenios Neboza, metropolitan of Holmogory, who died suddenly on 2 january 1704 in Yaroslavl. Author concludes that Dimitry of Rostov in 1701–1709 was not isolated from his old friends and mantained his ties with educated clergy of Little Russia during the years of his Episcopal service in Moscow and Rostov.

  2. Striving for LGBTQ rights in Russian psychology and society: A personal narrative

    Directory of Open Access Journals (Sweden)

    Igor I. Lunin

    2017-06-01

    Full Text Available Background. Based on a long personal story of dealing with LGBTQ rights in Russia, the author reviews several transformations in the psychological approach and research to gender and sexual identity. The author describes his professional growth as a psychologist. First his interest was in child sex-role development and then transformed to prevention of sexual crimes, AIDS prevention and sexual education among adolescents. The author shows how his area of expertise in human sexuality brought him to professional ethics for psychologists. Discussion. In the second part of the article the author reviews changes in social attitudes towards same sex- relationships from their criminalization and medicalization to acceptance and respect. The author emphasizes the pioneering role of Professor Igor Kon in changes of mass attitudes towards sexuality and same sex relationships. The author sees Kon’s legacy in his statement that “As long as gays and lesbians are objects of bullying and discrimination, everybody who considers himself/herself as a thinking person must support LGBTQ people’s fight for their human rights.” At the end of this part of the article, the author describes a recent hate crime based in homophobia, and its victim, the talented St. Petersburg journalist, Dmitry Tsilikin. Tsilikin was involved in sex education in the 1990s and published a book about these issues. His murder was not considered by the court to be a hate crime against an LGBTQ person, despite enormous protest from progressive-minded people all over Russia. Conclusion. The author recommends the Russian Psychological Ethics Code as a way to help psychologists support and advocate for people regardless of sexual orientation or gender identity.

  3. Exotic adventures en route to the antiworld

    International Nuclear Information System (INIS)

    Eades, J.

    1998-01-01

    Vladimir Korobov of the Joint Institute for Nuclear Research at Dubna in Russia and Dmitri Bakalov of the Institute for Nuclear Research and Nuclear Energy in Sofia, Bulgaria, have made a theoretical breakthrough in interpreting the properties of antiprotonic helium atoms (helium atoms in which an electron has been replaced by an antiproton) in terms of the properties of the antiproton itself. Classic quantum mechanics suggests that when such a atom is highly excited, the orbiting antiproton should quickly decay, emitting visible photons as it goes. One crucial defect in this argument is its neglect of the force between the antiproton and the remaining electron. More detailed calculations suggest that the antiproton will not have time to decay in such fashion, or emit any photons. So it came as a shock in 1990 when a group lead by Toshimitsu Yamazaki of Tokyo University showed that about 3% of all antiprotonic helium atoms survive for several microseconds in spite of the antiproton/electron interactions. This metastability against annihilations appears to be connected with a delay in the ejection of a second electron, during which time the antiprotonic atom continues to live. Furthermore, the electron seems to reduce the atom's sensitivity to collisions. This was confirmed in 1993 when the Japanese group, now joined by several European colleagues, showed that antiprotonic helium could indeed be stimulated by a laser beam to make a quantum jump of about 2 eV, from an n=39 level to an n=38 level (N Morita et al. 1994 Phys. Rev. Lett. 72 1180). This result highlights the importance of the Korobov and Bakalov paper. Since the second electron is essential for this metastability, its small but non-negligible interaction energy with the antiproton must be taken into account in calculations of energy levels. (UK)

  4. Евразийское будущее России в свете чередования интеграционных и дезинтеграционных циклов

    Directory of Open Access Journals (Sweden)

    Shuper Vjacheslav A.

    2016-11-01

    Full Text Available Russia needs to fit into the international geopolitical and geo-economic landscape. The formation of this landscape is largely determined by alternating integration and disintegration cycles in the development of the world economy. The second global disintegration cycle that started in 2008 is expected to last 15—20 years. It will be followed by a new integration cycle, largely dependent on China (Pax Sinensis instead of Pax Americana. This change necessitates a number of steps: a significant strengthening of the Eastern vector in the development of Russia, the formation of the Moscow-Beijing-New Delhi triangle (Evgeny Primakov's idea as well as providing access of energy-intensive and water-intensive goods from East Siberia by railway to the Chinese and Indian markets. Russia has expressed its interest in the construction of a railway from China to India. It will allow Russia to reduce transportation costs and use a potentially heavy transit traffic for the modernization of the Transsibirian railway. These steps could radically change the role of the Baltic exclave of Russia: from being a ‘window to Europe’ the region is to turn into the westernmost point of a infrastructure axis extending from east to west. The creation of such an axis, combined with a sharp fall in transportation costs will facilitate the access of energy-intensive and water-intensive goods from the Urals and Siberia to the Asian and European markets. The Kaliningrad region is increasingly taking on business facilitating functions, which used to be performed by the Soviet Baltic republics in the past. The region can play a more important role in the formation of Eurasia stretching from Shanghai to St. Petersburg (according to Dmitry Trenin, instead of the Europe from Lisbon to Vladivostok.

  5. High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

    Directory of Open Access Journals (Sweden)

    Mukthavaram R

    2013-10-01

    Full Text Available Rajesh Mukthavaram,1 Pengfei Jiang,1 Rohit Saklecha,1 Dmitri Simberg,3,4 Ila Sri Bharati,1 Natsuko Nomura,1 Ying Chao,1 Sandra Pastorino,1 Sandeep C Pingle,1 Valentina Fogal,1 Wolf Wrasidlo,1,2 Milan Makale,1,2 Santosh Kesari1,21Translational Neuro-Oncology Laboratories, 2Department of Neurosciences, 3Solid Tumor Therapeutics Program, Moores Cancer Center, UC San Diego, La Jolla, CA, 4Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Denver, CO, USAAbstract: Staurosporine (STS is a potent pan-kinase inhibitor with marked activity against several chemotherapy-resistant tumor types in vitro. The translational progress of this compound has been hindered by poor pharmacokinetics and toxicity. We sought to determine whether liposomal encapsulation of STS would enhance antitumor efficacy and reduce toxicity, thereby supporting the feasibility of further preclinical development. We developed a novel reverse pH gradient liposomal loading method for STS, with an optimal buffer type and drug-to-lipid ratio. Our approach produced 70% loading efficiency with good retention, and we provide, for the first time, an assessment of the in vivo antitumor activity of STS. A low intravenous dose (0.8 mg/kg inhibited U87 tumors in a murine flank model. Biodistribution showed preferential tumor accumulation, and body weight data, a sensitive index of STS toxicity, was unaffected by liposomal STS, but did decline with the free compound. In vitro experiments revealed that liposomal STS blocked Akt phosphorylation, induced poly(ADP-ribose polymerase cleavage, and produced cell death via apoptosis. This study provides a basis to explore further the feasibility of liposomally encapsulated STS, and potentially related compounds for the management of resistant solid tumors.Keywords: liposomes, staurosporine, glioblastoma, biodistribution, efficacy

  6. Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine

    Directory of Open Access Journals (Sweden)

    Li B

    2016-11-01

    Full Text Available Bo Li,1,2 Michael Siuta,1 Vanessa Bright,1,2 Dmitry Koktysh,3,4 Brittany K Matlock,5 Megan E Dumas,1 Meiying Zhu,1 Alex Holt,1 Donald Stec,3,6 Shenglou Deng,7 Paul B Savage,7 Sebastian Joyce,8,9 Wellington Pham1,2,6,10–12 1Institute of Imaging Science, Vanderbilt University School of Medicine, 2Department of Radiology and Radiological Sciences, 3Department of Chemistry, Vanderbilt University, 4Vanderbilt Institute of Nanoscale Science and Engineering, 5Vanderbilt Flow Cytometry Shared Resource, Vanderbilt University, 6Vanderbilt Institute of Chemical Biology, 7Department of Chemistry and Biochemistry, Brigham Young University, 8Department of Pathology, Microbiology and Immunology, Vanderbilt University, 9Veterans Administration Tennessee Valley Healthcare System, 10Department of Biomedical Engineering, 11Vanderbilt Ingram Cancer Center, 12Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA Abstract: The present study investigated the immunoenhancing property of our newly designed nanovaccine, that is, its ability to induce antigen-specific immunity. This study also evaluated the synergistic effect of a novel compound PBS-44, an α-galactosylceramide analog, in boosting the immune response induced by our nanovaccine. The nanovaccine was prepared by encapsulating ovalbumin (ova and an adjuvant within the poly(lactic-co-glycolic acid nanoparticles. Quantitative analysis of our study data showed that the encapsulated vaccine was physically and biologically stable; the core content of our nanovaccine was found to be released steadily and slowly, and nearly 90% of the core content was slowly released over the course of 25 days. The in vivo immunization studies exhibited that the nanovaccine induced stronger and longer immune responses compared to its soluble counterpart. Similarly, intranasal inhalation of the nanovaccine induced more robust antigen-specific CD8+ T cell response than intraperitoneal injection of nanovaccine

  7. Gazettes sous influence : le Courrier du Bas-Rhin, la Gazette des Deux-Ponts et les sujets touchant la Russie vers 1770

    Directory of Open Access Journals (Sweden)

    Georges Dulac

    2016-11-01

    Full Text Available Vers 1770, la campagne anti-russe du gouvernement français tend à dégrader l’image de la Russie, ce qui lèse gravement ses intérêts, notamment quand elle doit emprunter pour financer la guerre avec la Turquie. Aussi le prince Dmitri Alexeevitch Golitsyn, ministre plénipotentiaire à La Haye, se montre-t-il alors très actif sur ce terrain. Sa correspondance avec Pétersbourg témoigne de ses efforts, aux effets inégaux, pour influer sur les informations diffusées par quelques journaux : principalement le Courrier du Bas-Rhin, publié par Jean Manzon à Trèves, sous contrôle prussien, et dans une moindre mesure les deux Gazettes des Deux-Ponts, l’une politique, l’autre littéraire. Le journaliste de Trèves, qui trouve son intérêt à prendre le parti de la Russie, met en œuvre en sa faveur un discours journalistique abondant et parfois très élaboré. Cependant, la ligne du journal subit des fluctuations sensibles, selon l’évolution de la situation et à la suite de diverses interventions, dont celles du roi de Prusse et d’autre part de Stanislas-Auguste, qui pensionne un temps le journaliste. La Gazette des deux Ponts pratique l’information orientée avec plus de finesse, et, comme la gazette littéraire, accorde une large place à la matière russe : mais sur le plan politique, son traitement reste le plus souvent sous influence française et répond rarement aux vœux de D. A. Golitsyn.

  8. Safety and efficacy of nurse-controlled analgesia in patients less than 1 year of age

    Directory of Open Access Journals (Sweden)

    Walia H

    2016-06-01

    Full Text Available Hina Walia,1 Dmitry Tumin,1 Sharon Wrona,1 David Martin,1,2 Tarun Bhalla,1,2 Joseph D Tobias,1-3 1Department of Anesthesiology and Pain Medicine, Nationwide Children’s Hospital, 2Department of Anesthesiology and Pain Medicine, 3Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA Background: The management of acute pain presents unique challenges in the younger pediatric population. Although patient-controlled devices are frequently used in patients ≥6 years of age, alternative modes of analgesic delivery are needed in infants.Objective: To examine the safety and efficacy of nurse-controlled analgesia (NCA in neonates less than 1 year of age.Methods: Data from patients <1 year of age receiving NCA as ordered by the Acute Pain Service at our institution were collected over a 5-year period and reviewed retrospectively. The primary outcomes were activation of the institution’s Rapid Response Team (RRT or Code Blue, signifying severe adverse events. Pain score after NCA initiation was a secondary outcome.Results: Among 338 girls and 431 boys, the most common opioid used for NCA was fentanyl, followed by morphine and hydromorphone. There were 39 (5% cases involving RRT or Code Blue activation, of which only one (Code Blue was activated due to a complication of NCA (apnea. Multivariable logistic regression demonstrated morphine NCA to be associated with greater odds of RRT activation (OR=3.29, 95% CI=1.35, 8.03, P=0.009 compared to fentanyl NCA. There were no statistically significant differences in pain scores after NCA initiation across NCA agents.Conclusion: NCA is safe in neonates and infants, with comparable efficacy demonstrated for the three agents used. The elevated incidence of RRT activation in patients receiving morphine suggests caution in its use and consideration of alternative agents in this population. Keywords: nurse-controlled analgesia, pain medicine, Rapid Response Team

  9. IUPAC Periodic Table of Isotopes for the Educational Community

    Energy Technology Data Exchange (ETDEWEB)

    Holden N. E.; Holden,N.E.; Coplen,T.B.

    2012-07-15

    John Dalton first proposed the concept of atomic weights of the elements in the first decade of the nineteenth century. These atomic weights of the chemical elements were thought of as constants of nature, similar to the speed of light. Dmitri Mendeleev arranged the atomic weights of the elements in ascending order of value and used the systematic variation of their chemical properties to produce his Periodic Table of the Elements in 1869. Measurement of atomic weight values became an important chemical activity for a century and a half. Theodore Richards received a Noble Prize for his work in this area. In 1913, Fredrick Soddy found a species of radium, which had an atomic weight value of 228, compared to the familiar radium gas value of 226. Soddy coined the term 'isotope' (Greek for 'in the same place') to account for this second atomic weight value in the radium position of the Periodic Table. Both of these isotopes of radium are radioactive. Radioactive isotopes are energetically unstable and will decay (disintegrate) over time. The time it takes for one half of a sample of a given radioactive isotope to decay is the half-life of that isotope. In addition to having different atomic weight values, radium-226 and radium-228 also have different half-life values. Around the same time as Soddy's work, J.J. Thomson (discoverer of the electron) identified two stable (non-radioactive) isotopes of the same element, neon. Over the next 40 years, the majority of the known chemical elements were found to have two or more stable (or long-lived radioactive isotopes that contribute significantly to the determination of the atomic weights of the elements).

  10. Societal savings in patients with advanced non-squamous non-small-cell lung cancer receiving bevacizumab-based versus non-bevacizumab-based treatments in France, Germany, Italy, and Spain

    Directory of Open Access Journals (Sweden)

    Lister J

    2012-10-01

    Full Text Available Johanna Lister,1 Sanja Stanisic,1 Klaus Kaier,2 Christian Hagist,2 Dmitry Gultyaev,1 Stefan Walzer31Analytica LA-SER International Inc, Lörrach, Germany; 2Research Centre for Generational Contracts, University of Freiburg, Freiburg, Germany; 3F Hoffmann-La Roche Ltd, Pharmaceuticals Division, Basel, SwitzerlandBackground: The purpose of this study was to investigate the savings accrued using bevacizumab-based treatment for non-small-cell lung cancer from the societal perspective, taking only public costs into account, in France, Germany, Italy, and Spain.Methods: Societal costs were estimated by collecting and analyzing labor costs, carer costs, sickness benefits, disability benefits, and home care benefits. Cost inputs were derived from publicly available databases or from the published literature. Expert opinion was only used if no other source was available. Efficacy data from two randomized clinical trials were used. The time horizon in the health economic model was lifetime. Efficacy and costs were discounted by 3.5%. All main model parameters were tested in deterministic and probabilistic sensitivity analyses.Results: Mean incremental savings to society per patient ranged from €2277 in Italy to €4461 in Germany. The results were most sensitive to the change in proportion of patients working full-time and the proportion of patients who were able to return to work.Conclusion: This analysis shows that bevacizumab-based treatment in non-small-cell lung cancer is associated with more savings to society compared to standard chemotherapy in terms of increased productivity and decreased social benefits paid to patients who are able to work in France, Germany, Italy, and Spain.Keywords: non-small-cell lung cancer, bevacizumab, chemotherapy, economic model, France, Germany, Italy, Spain

  11. IUPAC Periodic Table of Isotopes for the Educational Community

    International Nuclear Information System (INIS)

    Holden, N.E.; Coplen, T.B.

    2012-01-01

    John Dalton first proposed the concept of atomic weights of the elements in the first decade of the nineteenth century. These atomic weights of the chemical elements were thought of as constants of nature, similar to the speed of light. Dmitri Mendeleev arranged the atomic weights of the elements in ascending order of value and used the systematic variation of their chemical properties to produce his Periodic Table of the Elements in 1869. Measurement of atomic weight values became an important chemical activity for a century and a half. Theodore Richards received a Noble Prize for his work in this area. In 1913, Fredrick Soddy found a species of radium, which had an atomic weight value of 228, compared to the familiar radium gas value of 226. Soddy coined the term 'isotope' (Greek for 'in the same place') to account for this second atomic weight value in the radium position of the Periodic Table. Both of these isotopes of radium are radioactive. Radioactive isotopes are energetically unstable and will decay (disintegrate) over time. The time it takes for one half of a sample of a given radioactive isotope to decay is the half-life of that isotope. In addition to having different atomic weight values, radium-226 and radium-228 also have different half-life values. Around the same time as Soddy's work, J.J. Thomson (discoverer of the electron) identified two stable (non-radioactive) isotopes of the same element, neon. Over the next 40 years, the majority of the known chemical elements were found to have two or more stable (or long-lived radioactive isotopes that contribute significantly to the determination of the atomic weights of the elements).

  12. The Coming Revolution of Peer Production and Revolutionary Cooperatives. A Response to Michel Bauwens, Vasilis Kostakis and Stefan Meretz

    Directory of Open Access Journals (Sweden)

    Jakob Rigi

    2014-04-01

    Full Text Available This article agrees with Meretz (2014 that the peer producing cooperatives which are proposed by Bauwens & Kostakis (2014 will become parts and parcels of the capitalist economy. Further, it argues that the so called Peer Production Licenses (PPL, originally designed by Dmitry Kleiner (2010, which is the basis of their proposal is a rent seeking instrument. Contra Bauwens & Kostakis, it argues that, from the perspectives of both reform and revolution, GPL is profoundly anti-capitalist. The article critiques Meretz`s understanding of exchange and reciprocity, on the one hand, and his underestimation of GPL`s communist aspect, on the other. On the positive side, the article, explicating the communist nature of GPL-oriented peer production, speculates about the general contours of a society where peer production is the dominant mode of production. The technological basis of this society, the article suggests, will be digital copying and automation. Spatially, it will be based on localities that transcend the current division between the city and country, synthesising agriculture with industrial, affective and symbolic production. The rise of a globally unified revolutionary social struggle which adopts peer production as its platform is indispensible for the transformation of capitalism into such a society.  A global network of revolutionary peer producing cooperatives which break with market and reduce their relations to it to an absolutely unavoidable necessary minimum can be a significant component of this social struggle. The building of these revolutionary cooperatives requires a massive exodus from the city to the country.

  13. Space Solar Power Exploratory Research and Technology (SERT) Technical Interchange Meeting 2 (SERT TIM 2)

    Science.gov (United States)

    Howell, Joe; Sanders, Clark W.

    2000-01-01

    The University of Alabama in Huntsville's (UAH) Propulsion Research Center hosted the Space Solar Power Exploratory Research & Technology (SERT) Technical Interchange Meeting TIM) 2 in Huntsville, Alabama December 7-10. 1999 with 126 people in attendance. The SERT program includes both competitively procured activities. which are being implemented through a portfolio of focused R&D investments--with the maximum leveraging of existing resources inside and outside NASA. and guided by these system studies. Axel Roth. Director of the Flight Projects Directorate NASA MSFC, welcomed the SERT TIM 2 participants and challenged them to develop the necessary technologies and demonstrations that will lead to Space Solar Power (SSP) International implementation. Joe Howell, NASA MSFC, reiterated the SERT TIM 2 objectives: 1) Refining and modeling systems approaches for the utilization of SSP concepts and technologies, ranging, from the near-term e.g. for space science, exploration and commercial space applications to the far-term (e. g. SSP for terrestrial markets), including systems concepts, technology, infrastructure (i.g., transportation), and economics. 2) Conducting technology research, development and demonstration activities to produce "proof- of-concept" validation of critical SSP elements for both the nearer and farther-term applications. 3) Initiating partnerships Nationality and Internationally that could be expanded, as appropriate, to pursue later SSP technology and applications (e.g., space science. colonization, etc.). Day one began with the NASA Centers presenting their SERT activities summary since SERT TIM 1 and wound up with a presentation by Masahiro Mori, NASDA titled "NASDA In-house Study for SSP". Demonstration for the Near-Term. Day two began with the SERT Systems Studies and Analysis reports resulting from NRA 8-23 followed by presentations of SERT Technology Demonstrations reports resulting from NRA 8-23. Day two closed with John Mankins presentation

  14. The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis.

    Science.gov (United States)

    Lindström, Erik; Rizoska, Biljana; Tunblad, Karin; Edenius, Charlotte; Bendele, Alison M; Maul, Don; Larson, Michael; Shah, Neha; Yoder Otto, Valerie; Jerome, Chris; Grabowska, Urszula

    2018-03-09

    MIV-711 is a highly potent and selective cathepsin K inhibitor. The current article summarizes the therapeutic effects of MIV-711 on joint pathology in rabbits subjected to anterior cruciate ligament transection (ACLT), and the prophylactic effects on joint pathology in dogs subjected to partial medial meniscectomy, two surgical models of osteoarthritis (OA). Starting 1 week after surgery, rabbits were dosed daily via oral gavage with either MIV-711 or vehicle (n = 7/group) for 7 weeks. The four treatment groups were: (1) sham + vehicle; (2) ACLT + vehicle; (3) ACLT + MIV-711, 30 µmol/kg and (4) ACLT + MIV-711, 100 µmol/kg. Subchondral bone and articular cartilage structures were assessed by µCT, histomorphometry, and scoring. Dogs subjected to partial medial meniscectomy received either MIV-711 (30 µmol/kg) or vehicle (n = 15/group) via oral gavage once daily, starting 1 day before meniscectomy, for 28 days. Cartilage degradation was assessed at the macroscopic and microscopic levels. The exposures of MIV-711 were assessed in both studies and biomarkers reflecting bone resorption (HP-1 in rabbits, CTX-I in dogs) and cartilage degradation (CTX-II) were measured. In ACLT rabbits, MIV-711 decreased HP-1 levels by up to 72% (p subchondral bone plate and reduced trabecular bone volume in the femur and tibia. These effects were reversed by MIV-711. ACLT resulted in cartilage thickening, which was attenuated by MIV-711. MIV-711 did not affect osteophyte formation or Mankin scores. In dogs, MIV-711 reduced CTX-I and CTX-II levels by 86% (p subchondral bone loss and partially attenuates cartilage pathology in two animal models of OA. These beneficial effects of MIV-711 on joint pathology are observed in conjunction with decreases in bone and cartilage biomarkers that have been shown to be clinically attainable in human. The data support the further development of MIV-711 for the treatment of OA.

  15. The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis.

    Science.gov (United States)

    Hwa, S Y; Burkhardt, D; Little, C; Ghosh, P

    2001-04-01

    An ovine model of osteoarthritis (OA) induced by bilateral lateral meniscectomy (BLM) was used to evaluate in vivo effects of the slow acting antiarthritic drug diacerein (DIA) on degenerative changes in cartilage and subchondral bone of the operated joints. Twenty of 30 adult age matched Merino wethers were subjected to BLM in the knee joints and the remainder served as non-operated controls (NOC). Half of the BLM group (n = 10) were given DIA (25 mg/kg orally) daily for 3 mo, then 50 mg/kg daily for a further 6 mo. The remainder of the meniscectomized (MEN) group served as OA controls. Five DIA, 5 MEN, and 5 NOC animals were sacrificed at 3 mo and the remainder at 9 mo postsurgery. One knee joint of each animal was used for bone mineral density (BMD) studies. Osteochondral slabs from the lateral femoral condyle and lateral tibial plateau were cut from the contralateral joint and were processed for histological and histomorphometric examination to assess the cartilage and subchondral bone changes. No significant difference was observed in the modified Mankin scores for cartilage from the DIA and MEN groups at 3 or 9 mo. However, in animals treated with DIA, the thickness of cartilage (p = 0.05) and subchondral bone (p = 0.05) in the lesion (middle) zone of the lateral tibial plateau were decreased relative to the corresponding zone of the MEN group at 3 mo (p = 0.05). At 9 mo subchondral bone thickness in this zone remained the same as NOC but BMD, which included both subchondral and trabecular bone, was significantly increased relative to the NOC group (p = 0.01). In contrast, the subchondral bone thickness of the outer zone of lateral tibial plateau and lateral femoral condyle of both MEN and DIA groups increased after 9 mo, while BMD remained the same as in the NOC. DIA treatment of meniscectomized animals mediated selective responses of cartilage and subchondral bone to the altered mechanical stresses induced across the joints by this procedure. While

  16. Interphalangeal Osteoarthritis Radiographic Simplified (iOARS) score: a radiographic method to detect osteoarthritis of the interphalangeal finger joints based on its histopathological alterations.

    Science.gov (United States)

    Sunk, Ilse-Gerlinde; Amoyo-Minar, Love; Stamm, Tanja; Haider, Stefanie; Niederreiter, Birgit; Supp, Gabriela; Soleiman, Afschin; Kainberger, Franz; Smolen, Josef S; Bobacz, Klaus

    2014-11-01

    To develop a radiographic score for assessment of hand osteoarthritis (OA) that is based on histopathological alterations of the distal (DIP) and proximal (PIP) interphalangeal joints. DIP and PIP joints were obtained from corpses (n=40). Plain radiographies of these joints were taken. Joint samples were prepared for histological analysis; cartilage damage was graded according to the Mankin scoring system. A 2×2 Fisher's exact test was applied to define those radiographic features most likely to be associated with histological alterations. Receiver operating characteristic curves were analysed to determine radiographic thresholds. Intraclass correlation coefficients (ICC) estimated intra- and inter-reader variability. Spearman's correlation was applied to examine the relationship between our score and histopathological changes. Differences between groups were determined by a Student's t test. The Interphalangeal Osteoarthritis Radiographic Simplified (iOARS) score is presented. The score is based on histopathological changes of DIP and PIP joints and follows a simple dichotomy whether OA is present or not. The iOARS score relies on three equally ranked radiographic features (osteophytes, joint space narrowing and subchondral sclerosis). For both DIP and PIP joints, the presence of one x-ray features reflects interphalangeal OA. Sensitivity and specificity for DIP joints were 92.3% and 90.9%, respectively, and 75% and 100% for PIP joints. All readers were able to reproduce their own readings in DIP and PIP joints after 4 weeks. The overall agreement between the three readers was good; ICCs ranged from 0.945 to 0.586. Additionally, outcomes of the iOARS score in a hand OA cohort revealed a higher prevalence of interphalangeal joint OA compared with the Kellgren and Lawrence score. The iOARS score is uniquely based on histopathological alterations of the interphalangeal joints in order to reliably determine OA of the DIP and PIP joints radiographically. Its high

  17. Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma cells

    Directory of Open Access Journals (Sweden)

    Zhang L

    2015-04-01

    Full Text Available Linlin Zhang,1,2,* Arun K lyer,3,4,* Xiaoqian Yang,1 Eisuke Kobayashi,1 Yuqi Guo,1,2 Henry Mankin,1 Francis J Hornicek,1 Mansoor M Amiji,3 Zhenfeng Duan1 1Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA; 2Department of Pathology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 3Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, USA; 4Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA *These authors contributed equally to this work Abstract: Our prior screening of microRNAs (miRs identified that miR-199a-3p expression is reduced in osteosarcoma cells, one of the most common types of bone tumor. miR-199a-3p exhibited functions of tumor cell growth inhibition, suggesting the potential application of miR-199a-3p as an anticancer agent. In the study reported here, we designed and developed a lipid-modified dextran-based polymeric nanoparticle platform for encapsulation of miRs, and determined the efficiency and efficacy of delivering miR-199a-3p into osteosarcoma cells. In addition, another potent miR, let-7a, which also displayed tumor suppressive ability, was selected as a candidate miR for evaluation. Fluorescence microscopy studies and real-time polymerase chain reaction results showed that dextran nanoparticles could deliver both miR-199a-3p and let-7a into osteosarcoma cell lines (KHOS and U-2OS successfully. Western blotting analysis and 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT assays demonstrated that dextran nanoparticles loaded with miRs could efficiently downregulate the expression of target proteins and effectively inhibit the growth and proliferation of osteosarcoma cells. These results demonstrate that a lipid-modified dextran

  18. List of Posters

    Science.gov (United States)

    List of Posters: Dark matter annihilation in the Galactic galo, by Dokuchaev Vyacheslav, et al. NEMO developments towards km3 telescope in the Mediterranean Sea. The NEMO project. Neutrino Mediterranean Observatory By Antonio Capone, NEMO Collaboration. Alignment as a result from QCD jet production or new still unknown physics at LHC? By Alexander Snigirev. Small-scale fluctuations of extensive air showers: systematics in energy and muon density estimation By Grigory Rubtsov. SHINIE: Simulation of High-Energy Neutrino Interacting with the Earth By Lin Guey-Lin, et al.. Thermodynamics of rotating solutions in n+1 dimensional Einstein - Maxwell -dilation gravity By Ahmad Sheykhi, et al.. Supernova neutrino physics with future large Cherenkov detectors By Daniele Montanino. Crossing of the Cosmological Constant Barrier in the string Inspired Dark Energy Model By S. Yu. Vernov. Calculations of radio signals produced by ultra-high and extremely high energy neutrino induced cascades in Antarctic ice By D. Besson, et al.. Inflation, Cosmic Acceleration and string Gravity By Ischwaree Neupane. Neutrino Physics: Charm and J/Psi production in the atmosphere By Liudmila Volkova. Three generation flavor transitions and decays of supernova relic neutrinos By Daniele Montanino. Lattice calculations & computational quantum field theory: Sonification of Quark and Baryon Spectra By Markum Harald, et al.. Generalized Kramers-Wannier Duality for spin systems with non-commutative symmetry By V. M. Buchstaber, et al.. Heavy ion collisions & quark matter: Nuclear matter jets and multifragmentation By Danut Argintaru, et al.. QCD hard interactions: The qT-spectrum of the Higgs and Slepton-pairs at the LHC By Guiseppe Bozzi. QCD soft interactions: Nonperturbative effects in Single-Spin Asymmetries: Instantons and TMD-parton distributions By Igor Cherednikov, et al.. Gluon dominance model and high multiplicity By Elena Kokoulina. Resonances in eta pi- pi- pi+ system By Dmitry Ryabchikov

  19. Welcome to the 21st International Conference on Spectral Line Shapes

    Science.gov (United States)

    2012-12-01

    Dear Participants and Guests On behalf of the Rector's Office, welcome to St. Petersburg University, one of the oldest, largest and most prestigious universities in Russia. The 12 Colleges Building (named after the Collegia of Peter the Great's time, Ministries in the modern sense of the word) has been home to the University since 1804. St. Petersburg State University is the successor of the first Russian University founded by Peter the Great on 24 January 1724. It's distinguished faculty members include mathematicians Chebyshev and Smirnov, physicists Lenz and Fock, chemists Mendeleev and Butlerov, embryologist Kovalevsky, and physiologist Sechenov. Several of our alumni won Nobel Prizes - Pavlov, Semenov, Kantorovich, Landau and Prokhorov. The University is the alma mater of two presidents of Russia, Vladimir Putin and Dmitry Medvedev. St. Petersburg State University today consists of 19 faculties on two campuses: in the historic downtown, on Vasilyevsky Island, and in Peterhof. The Faculty of Physics carries out research projects through the efforts of 260 employees, of which 150 hold doctoral degrees, and 50 have been awarded Grand Doctorates. The work is done in a vast variety of areas, from the physics of elementary particles to the physics of the atmosphere. Optics and spectroscopy has been a particularly significant area of research. This field of inquiry goes back to the work of Academician D S Rozhdestvensky more than 70 years ago, when he first suggested his famous hook method. After him the work was headed by S Frisch, corresponding member of the Academy of Sciences and editor-in-chief of Optics and Spectroscopy Journal. Today research projects in optics involve over 50 staff members, graduate and post-graduate students. Work involves projects on spectroscopy of cold and hot plasma, atomic and molecular spectroscopy, non-linear spectroscopy and spectroscopic analysis. Our scholars support active international ties with their colleagues worldwide. The

  20. PREFACE: 1st International School and Conference "Saint Petersburg OPEN 2014" on Optoelectronics, Photonics, Engineering and Nanostructures

    Science.gov (United States)

    2014-09-01

    Dear Colleagues, 1st International School and Conference "Saint Petersburg OPEN 2014" on Optoelectronics, Photonics, Engineering and Nanostructures was held on March 25 - 27, 2014 at St. Petersburg Academic University - Nanotechnology Research and Education Centre of the Russian Academy of Sciences. The School and Conference included a series of invited talks given by leading professors with the aim to introduce young scientists with actual problems and major advances in physics and technology. The keynote speakers were: Mikhail Glazov (Ioffe Physico-Technical Institute RAS, Russia) Vladimir Dubrovskii (Saint Petersburg Academic University RAS, Russia) Alexey Kavokin (University of Southampton, United Kingdom and St. Petersburg State University, Russia) Vladimir Korenev (Ioffe Physico-Technical Institute RAS, Russia) Sergey Kukushkin (Institute of Problems of Mechanical Engineering RAS, Russia) Nikita Pikhtin (Ioffe Physico-Technical Institute RAS, Russia and "Elfolum" Ltd., Russia) Dmitry Firsov (Saint Petersburg State Polytechnical University, Russia) During the poster session all undergraduate and graduate students attending the conference presented their works. Sufficiently large number of participants with more than 160 student attendees from all over the world allowed the Conference to provide a fertile ground for the fruitful discussions between the young scientists as well as to become a perfect platform for the valuable discussions between student authors and highly experienced scientists. The best student papers, which were selected by the Program Committee and by the invited speakers basing on the theses and their poster presentation, were awarded with diplomas of the conference - see the photos. This year's School and Conference is supported by SPIE (The International Society for Optics and Photonics), OSA (The Optical Society), St. Petersburg State Polytechnical University and by Skolkovo Foundation. It is a continuation of the annual schools and

  1. PREFACE: 21st International Conference on Laser Spectroscopy - ICOLS 2013

    Science.gov (United States)

    Budker, Dmitry; Häffner, Hartmut; Müller, Holger

    2013-12-01

    videos of the reception and banquet presentations available at the conference web site https://icols.berkeley.edu/. On behalf of the organizing and program committees, Berkeley, October 2013 Dmitry Budker, Hartmut Häffner, and Holger Müller

  2. New vision of magnetic tunnelling

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, Jonathan R. [Amherst College, Amhurst, MA (United States)

    2002-01-01

    Recent experiments support the idea that crystal defects may be responsible for the quantum tunnelling of magnetic moments in molecular magnets at low temperatures. The magnetic moment of a typical bar magnet will never spontaneously reverse direction. However, thermal fluctuations can flip the moment of a magnetic particle just a few nanometres across. The particle can be cooled to nearly absolute zero to suppress this process, but the moment may still find a way to reverse via quantum tunnelling. Quantum tunnelling of magnetization has been the subject of decades of research. Until a few years ago, however, there had only been circumstantial evidence for the phenomenon. This is because most systems of small magnetic particles are hard to characterize - the particles have a variety of shapes, sizes and other properties, making it difficult to compare data with theory. Some real progress was made a few years ago through research into high-spin single-molecule magnets. With dimensions of about a nanometre, these magnets are usually composed of a magnetic core that is surrounded by organic complexes. When they crystallize into a regular lattice, the organic ions keep neighbouring magnets well separated so that they interact only weakly. Ideally all the molecules are identical because they have been built chemically, which means that they can be characterized precisely and that any data can be analysed quantitatively. The most studied of these molecules is manganese-12 acetate (Mn{sub 12}). Within each molecule, the spins of the eight Mn{sup 3+} ions (each with S=2) are antiparallel to the spins of the four Mn{sup 4+} ions (each with S=3/2), giving Mn{sub 12} a total spin of S=10. Or, to put it another way, the magnetic moment of Mn{sub 12} is 20 times larger than that of the electron. Now Eugene Chudnovsky of Lehman College in New York and Dmitry Garanin of the University of Mainz in Germany have suggested a new mechanism for producing tunnelling in Mn{sub 12

  3. Biofilm infections between Scylla and Charybdis: interplay of host antimicrobial peptides and antibiotics

    Directory of Open Access Journals (Sweden)

    Chernysh S

    2018-04-01

    Full Text Available Sergey Chernysh,* Natalia Gordya,* Dmitry Tulin, Andrey Yakovlev Laboratory of Insect Biopharmacology and Immunology, Faculty of Biology, St. Petersburg State University, St. Petersburg, Russia *These authors contributed equally to this work Purpose: The aim of this study is to improve the anti-biofilm activity of antibiotics. We hypothesized that the antimicrobial peptide (AMP complex of the host’s immune system can be used for this purpose and examined the assumption on model biofilms. Methods: FLIP7, the AMP complex of the blowfly Calliphora vicina containing a combination of defensins, cecropins, diptericins and proline-rich peptides was isolated from the hemolymph of bacteria-challenged maggots. The complex interaction with antibiotics of various classes was studied in biofilm and planktonic cultures of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii by the checkerboard method using trimethyl tetrazolium chloride cell viability and crystal violet biofilm eradication assays supplemented with microscopic analysis. Results: We found that FLIP7 demonstrated: high synergy (fractional inhibitory concentration index <0.25 with meropenem, amikacin, kanamycin, ampicillin, vancomycin and cefotaxime; synergy with clindamycin, erythromycin and chloramphenicol; additive interaction with oxacillin, tetracycline, ciprofloxacin and gentamicin; and no interaction with polymyxin B. The interaction in planktonic cell models was significantly weaker than in biofilms of the same strains. The analysis of the dose–effect curves pointed to persister cells as a likely target of FLIP7 synergistic effect. The biofilm eradication assay showed that the effect also caused total destruction of S. aureus and E. coli biofilm materials. The effect allowed reducing the effective anti-biofilm concentration of the antibiotic to a level well below the one clinically achievable (2–3 orders of magnitude in

  4. Caregivers’ knowledge and acceptance of complementary and alternative medicine in a tertiary care pediatric hospital

    Directory of Open Access Journals (Sweden)

    Trifa M

    2018-03-01

    Full Text Available Mehdi Trifa,1,2 Dmitry Tumin,1,3 Hina Walia,1 Kathleen L Lemanek,4 Joseph D Tobias,1,3 Tarun Bhalla1,3 1Department of Anesthesiology and Pain Medicine, Nationwide Children’s Hospital, Columbus, OH, USA; 2Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia; 3Department of Anesthesiology and Pain Medicine, The Ohio State University College of Medicine, Columbus, OH, USA; 4Department of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, OH, USA Background: The use of complementary and alternative medicine (CAM therapies has increased in children, especially in those with chronic health conditions. However, this increase may not translate into acceptance of CAM in the perioperative setting. We surveyed caregivers of patients undergoing surgery to determine their knowledge and acceptance of hypnotherapy, acupuncture, and music therapy as alternatives to standard medication in the perioperative period. Materials and methods: An anonymous, 12-question survey was administered to caregivers of children undergoing procedures under general anesthesia. Caregivers reported their knowledge about hypnotherapy, music therapy, and acupuncture and interest in one of these methods during the perioperative period. CAM acceptance was defined as interest in one or more CAM methods.Results: Data from 164 caregivers were analyzed. The majority of caregivers were 20–40 years of age (68% and mothers of the patient (82%. Caregivers were most familiar with acupuncture (70%, followed by music therapy (60% and hypnotherapy (38%. Overall CAM acceptance was 51%. The acceptance of specific CAM modalities was highest for music therapy (50%, followed by hypnotherapy (17% and acupuncture (13%. In multivariable logistic regression, familiarity with music therapy was associated with greater odds of CAM acceptance (odds ratio=3.36; 95% CI: 1.46, 7.74; P=0.004.Conclusion: Overall CAM acceptance among caregivers of children

  5. The Russian Orthodox Church and atheism

    Directory of Open Access Journals (Sweden)

    Teuvo Laitila

    2012-06-01

    Full Text Available After the collapse of the Soviet Union in 1991, the religious tide in Russia has been quick to rise. During the Soviet era, religion – particularly Orthodox Christianity and Islam – was considered to be one of the ‘enemies of the people’. Since the late 1990s however, Russian politicians at all levels of the power structure have associated themselves either with the Orthodox, or on some occasions with the Muslim, clergy. The present state of affairs in the relations between religion and the state are well illustrated by the cordial liaison of the late Patriarch Aleksii II with President Vladimir Putin and the equally warm involvement of President Dmitry Medvedev, and his wife Svetlana Medvedeva, with the new Patriarch Kirill, who was elected in January 2009. Some have even argued that ‘today’ (in 2004 the Church and state are so extensively intertwined that one can no longer consider Russia to be a secular state. Polls seem to support the claim. While in 1990 only 24 per cent of Russians identified themselves as Orthodox, in the sense that they felt themselves to be Russians as well, in 2008 the number was 73 per cent. However, less than 10 per cent, and in Moscow perhaps only 2 per cent do actually live out their religiosity.Why did Russia turn towards religion? Is religion chosen in an attempt to legitimise power, or in order to consolidate political rule after atheist-communist failure? My guess is that the answer to both is affirmative. Moreover, whatever the personal convictions of individual Russians, including politicians, religious, mainly Orthodox Christian, rhetoric and rituals are used to make a definitive break with the communist past and to create, or re-create, a Greater Russia (see Simons 2009. In such an ideological climate, atheism has little chance of thriving, whereas there is a sort of ‘social demand’ for its critique.I therefore focus on what the Russian Orthodox Church (ROC has had to say about atheism and

  6. A study on the efficacy and safety of combining dental surgery with tonsillectomy in pediatrics

    Directory of Open Access Journals (Sweden)

    Syed F

    2018-03-01

    Full Text Available Faizaan Syed,1 Joshua C Uffman,1,2 Dmitry Tumin,1 Catherine M Flaitz,3,4 Joseph D Tobias,1,2 Vidya T Raman1,2 1Department of Anesthesiology & Pain Medicine, Nationwide Children’s Hospital, 2Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, 3Department of Dentistry, Nationwide Children’s Hospital, 4Division of Dentistry, The Ohio State University College of Dentistry, Columbus, OH, USA Purpose: Few data exist on combining pediatric surgical procedures under a single general anesthetic encounter (general anesthesia. We compared perioperative outcomes of combining dental surgical procedures with tonsillectomy during one anesthetic vs separate encounters. Methods: We classified elective tonsillectomy ± adenoidectomy and restorative dentistry as combined (group C or separate (group S. Outcomes included anesthesia time, recovery duration, the need for overnight hospital stay, and postoperative complications. Results: Patients aged 4±1 years underwent tonsillectomy and dental surgery in combination (n=7 or separately (n=27. No differences were noted in total anesthesia time (C: median: 150, interquartile range [IQR]: 99, 165 vs S: median: 109, IQR: 92, 132; 95% CI of difference in median: –58, +10 minutes; P=0.115 and total recovery time (C: median: 54, IQR: 40, 108 vs S: median: 72, IQR: 58, 109; 95% CI of difference in median: –16, +48 minutes; P=0.307. The need for overnight stay (C: 4 of 7, S: 20 of 27; P=0.394 did not differ between the groups. No postoperative complications were noted in either group. Conclusion: These preliminary data support the potential feasibility of combining dental procedures with tonsillectomy during a single anesthetic encounter. Such care may not only reduce costs but also limit parental work absences and increase convenience for patient families. When compared with procedures performed separately, combined procedures did not result in increased morbidity or

  7. A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression

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    Green HN

    2014-11-01

    Full Text Available Hadiyah N Green,1,2 Stephanie D Crockett,3 Dmitry V Martyshkin,1 Karan P Singh,2,4 William E Grizzle,2,5 Eben L Rosenthal,2,6 Sergey B Mirov11Department of Physics, Center for Optical Sensors and Spectroscopies, 2Comprehensive Cancer Center, 3Department of Pediatrics, Division of Neonatology, 4Department of Medicine, Division of Preventive Medicine, Biostatistics and Bioinformatics Shared Facility, 5Department of Pathology, 6Department of Surgery, Division of Otolaryngology, Head and Neck Surgery, The University of Alabama at Birmingham, Birmingham, AL, USAPurpose: Nanoparticle (NP-enabled near infrared (NIR photothermal therapy has realized limited success in in vivo studies as a potential localized cancer therapy. This is primarily due to a lack of successful methods that can prevent NP uptake by the reticuloendothelial system, especially the liver and kidney, and deliver sufficient quantities of intravenously injected NPs to the tumor site. Histological evaluation of photothermal therapy-induced tumor regression is also neglected in the current literature. This report demonstrates and histologically evaluates the in vivo potential of NIR photothermal therapy by circumventing the challenges of intravenous NP delivery and tumor targeting found in other photothermal therapy studies.Methods: Subcutaneous Cal 27 squamous cell carcinoma xenografts received photothermal nanotherapy treatments, radial injections of polyethylene glycol (PEG-ylated gold nanorods and one NIR 785 nm laser irradiation for 10 minutes at 9.5 W/cm2. Tumor response was measured for 10–15 days, gross changes in tumor size were evaluated, and the remaining tumors or scar tissues were excised and histologically analyzed.Results: The single treatment of intratumoral nanorod injections followed by a 10 minute NIR laser treatment also known as photothermal nanotherapy, resulted in ~100% tumor regression in ~90% of treated tumors, which was statistically significant in a

  8. The influence of CYP3A5 polymorphisms on haloperidol treatment in patients with alcohol addiction

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    Zastrozhin MS

    2017-12-01

    Full Text Available Mikhail Sergeevich Zastrozhin,1,2 Elena Anatolievna Grishina,1 Kristina Anatolievna Ryzhikova,1 Valery Valerievich Smirnov,3 Ludmila Mikhailovna Savchenko,1 Evgeny Alekseevich Bryun,1,2 Dmitry Alekseevich Sychev1 1Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, 2Moscow Research and Practical Centre on Addictions, Moscow Department of Healthcare, 3National Research Center Institute of Immunology, Federal Medical-Biological Agency, Moscow, Russia Background: Isoenzymes CYP2D6 and CYP3A4, the activity of which varies widely, are involved in metabolism of haloperidol and may influence its profile of efficacy and safety.Objective: The primary aim of this study was to estimate the relationship between CYP3A5 gene polymorphism, activity of the CYP3A isoenzyme, and the risk of development of adverse drug reactions by haloperidol in patients with alcohol abuse.Methods: Sixty-six male alcohol-addicted patients participated in the study. The safety of haloperidol was evaluated by Udvalg for Kliniske Undersogelser Side Effect Rating Scale (UKU and Simpson–Angus Scale for extrapyramidal symptoms (SAS. The activity of CYP3A was evaluated by determining the concentrations of an endogenous substrate of this isoenzyme (cortisol and its urinary metabolite (6-beta-hydroxycortisol, 6-B-HC. Genotyping of CYP3A5*3 was performed by real-time polymerase chain reaction with allele-specific hybridization.Results: The frequency of A-allele occurrence in Russian population was very poor (2.27%. CYP3A5*3 polymorphism had no influence on safety profile indicators of haloperidol (UKU scale: p=0.55, SAS scale: p=0.64. In addition, there was no statistical significant difference between the values of indexes of the metabolic ratio (6-B-HC/cortisol in groups with different genotypes of CYP3A5*3: GG 5.00 (3.36; 6.39 vs AG 5.26 (2.10; 6.78 (p=0.902.Conclusion: The frequency of A-allele occurrence of CYP3A5*3 in Russian

  9. Effect of self-assembled peptide–mesenchymal stem cell complex on the progression of osteoarthritis in a rat model

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    Kim JE

    2014-05-01

    metalloproteinases 1, and matrix metalloproteinase 9 were diffusely stained in controls, whereas localized or minimal staining was observed in other groups. Modified Mankin scores were significantly lower in the SAP and SAP-MSC groups than in controls (P=0.001 and 0.013. Although not statistically significant, synovial inflammation scores were lower in the SAP (1.3±0.3 and SAP-MSC (1.3±0.2 groups than in controls (2.6±0.2. However, neither the cytokine level nor the behavioral score was significantly different between groups.Conclusion: Injection of SAP-MSC hydrogels showed evidence of chondroprotection, as measured by the histologic grading and decreased expression of biochemical markers of inflammation and apoptosis. It also lowered subchondral bone mineral density, which can be increased by OA. This suggests that the SAP-MSC complex may have clinical potential to inhibit OA progression.Keywords: self-assembled peptide, mesenchymal stem cell, osteoarthritis, apoptosis, chondrogenesis

  10. İntraartiküler propolis ekstraktının erişkin sıçanlarda deneysel osteoartrit tedavisinde etkinliği

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    Gökçen Kerimoğlu

    2017-12-01

    Full Text Available Amaç: Eklem kıkırdağının kendini tamir edebilme yeteneği oldukça sınırlıdır. Dejeneratif osteoartrit (OA, eklemde özellikle eklem kıkırdağı ve subkondral kemikte ilerleyici dejenerasyonla karakterizedir. Bazı sitokinler, matriks metalloproteinazlarının (MMP ve kondrosit kaynaklı katabolik maddelerin salınımını artırarak kıkırdak harabiyetini hızlandırırlar. Bal arıları tarafından üretilen propolis sitokinler ve MMP üzerinde etkiye sahiptir . Bu çalışma; intraartiküler propolis uygulanmasının deneysel osteoartrit üzerine etkilerini araştırmayı amaçlamaktadır. Yöntemler: Çalışmada kullanılan 21 adet Spraque Dawley cinsi dişi sıçan sadece artrotomi yapılan (A, artrotomi ve intraartiküler propolis uygulanan (P ve artrotomi ve intraartiküler serum fizyolojik uygulanan (SF olmak üzere üç gruba ayrıldı. P grubuna artrotomi sonrası 3. haftadan itibaren toplam üç hafta, haftada bir kez olacak şekilde 0.5 mg/ml konsantrasyondaki propolisten 0.1 ml intraartiküler verildi. SF grubuna ise P grubuyla aynı zamanlarda serum fizyolojik verildi. 6. hafta sonunda bütün sıçanlar servikal dislokasyon yoluyla sakrifiye edildi ve alınan diz eklemleri Safranin O-Fast Green ile boyanarak Mankin Skorlamasına göre histolojik olarak değerlendirildi. Bulgular: Yapılan histolojik skorlamada gruplardaki ortalama skorlar;A grubunda 0.57; SF grubunda 10.1 ve P grubunda ise 5.57 puan olarak hesaplanmıştır. A grubunda; eklem yüzeyi kıkırdak yapısının, boyanmasının ve hücrelerinin genel olarak normal olduğu görüldü. SF grubunda, kıkırdak yüzeyinde yarıklar; hücrelerinde ve matriks boyanmasında ciddi bozukluk mevcut olduğu gözlendi. P grubunda ise boyanmada azalma ve hücrelerde gruplaşmalar görülse de eklem yüzeyi SF grubuna göre daha düzgündü. Sonuç: İntraartikülerpropolisekstraktı uygulamasının deneysel OA oluşumunu azaltıcı etkisi olabilir.

  11. Determination of characteristics of degenerative joint disease using optical coherence tomography and polarization sensitive optical coherence tomography.

    Science.gov (United States)

    Xie, Tuqiang; Guo, Shuguang; Zhang, Jun; Chen, Zhongping; Peavy, George M

    2006-10-01

    Previous studies have demonstrated that optical coherence tomography (OCT) could be used to delineate alterations in the microstructure of cartilage, and have suggested that changes in the polarization state of light as detected by OCT could provide information on the birefringence properties of articular cartilage as influenced by disease. In this study we have used both OCT and polarization sensitive optical coherence tomography (PS-OCT) technologies to evaluate normal and abnormal bovine articular cartilage according to established structural, organizational, and birefringent characteristics of degenerative joint disease (DJD) in order to determine if this technology can be used to differentiate various stages of DJD as a minimally invasive imaging tool. Fresh bovine femoral-tibial joints were obtained from an abattoir, and 45 cartilage specimens were harvested from 8 tibial plateaus. Whole ex vivo specimens of normal and degenerative articular cartilage were imaged by both OCT and PS-OCT, then fixed and processed for histological evaluation. OCT/PS-OCT images and corresponding histology sections of each specimen were scored according to a modified Mankin structural grading scale and compared. OCT and PS-OCT imaging allowed structural evaluation of intact articular cartilage along a 6 mm surface length to a depth of 2 mm with a transverse resolution of 12 microm and an axial resolution of 10 microm. The OCT and PS-OCT images demonstrated characteristic alterations in the structure of articular cartilage with a high correlation to histological evaluation (kappa = 0.776). The OCT images were able to demonstrate early to advanced structural changes of articular cartilage while the optical phase retardation images obtained by PS-OCT imaging were able to discriminate areas where disorganization of the cartilage matrix was present, however, these characteristics are much different than those reported where OCT images alone were used to characterize tissue

  12. OBITUARY: Dorianna Twersky (1922-2010) Dorianna Twersky (1922-2010)

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    Thomas, P.

    2010-03-01

    Dorianna Twersky, Editor Emerita of Nuclear Fusion, passed away on 22 January 2010. Dorianna was Editor of Nuclear Fusion for nearly two decades, from 1967 to 1985. During her tenure, the journal underwent an impressive development. In 1967 Nuclear Fusion was a quarterly with 300 pages published each year, by 1978 it had become a monthly journal. Reflecting the developments in the field, it had evolved from a general plasma physics journal to one that was far more fusion relevant. Dorianna ensured that Nuclear Fusion had a strong peer review system and that effective journal policies were developed and adhered to. Dorianna drove the success of the journal. Her dynamic personality and commitment to the international fusion community underpinned that success. She had a well deserved reputation for toughness and for critical and intuitive thinking. Perhaps her most valuable trait was her persuasiveness and ability to motivate people to help with the journal and contribute to its development. She was able to inspire a sense of dedication and enthusiasm in the people she worked with and was highly respected. Dorianna Twersky will be greatly missed. Four of the prominent scientists who served on the Nuclear Fusion Board of Editors during Dorianna's Editorship have written a few lines in her memory: Professor Dmitri Ryutov, Professor Folker Engelmann, Professor Jim Callen and Professor Karl Lackner. "Dorianna Twersky was one of the best journal editors who I have met during my half-century in physics and plasma physics. An author and a referee would immediately sense that she was a friendly and open-minded person who would always try to resolve conflicts in a constructive way. That was the time well before the emergence of the Internet, and the paper correspondence added a personal touch to the journal business. Sometimes she would add a handwritten joke, or a small cartoon at the corner of her letter. Dorianna spoke perfect Russian. That was of significant help to a

  13. Satire in Music

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    Leon Stefanija

    2011-12-01

    Full Text Available The article surveys the scope of satire and suggests its range. It is divided into six sections. The introductory comment (The semantics of music briefly outlines the fact that music has always been a part of communicative endeavors. The historical background of the semantic issues in music is described (Historical surmises, which is necessary to define satire in music as a specific genre combining features from different musical forms. The third section discusses six areas as the most common contexts of musical satire: 1 satirical music theater works, such as the opera Il Girello by Jacopo Melani, the famous Coff ee Cantata (Schweigt Still, plaudert nicht, BWV 211 by Johann Sebastian Bach, Der Schulmeister by Georg Philipp Telemann, The Beggar’s Opera by John Gay, and so on; 2 musical genres associated with satire, either a within vocal-instrumental music; for instance, opera buffa, Singspiel, operetta, cabaret, vaudeville, and so on, or b in instrumental pieces, such as capriccios, grotesques, scherzos, burlesques, and so on; 3 individual features or compositional parts related to satire; for example, in a vocal music, the Satiro in Orfeo by Luigi Rossi, the range of the Orlando character in eighteenth-century opera, who “may be satire, a fool or hero, but never all together” (Harris, 1986, 106, the satirical antihero Matěj Brouček in Leoš Janáček’s work, and also Lady Macbeth, and in b instrumental music, such as the sermon of St. Anthony in Gustav Mahler’s Second Symphony, his marches, and “low-brow tunes,” a number of episodes in Dmitri Shostakovich’s works, and so on; 4 works variously related to criticism, such as the work of Eric Satie, Kurt Weill, Luigi Nono, Maurizio Kagel, and Vinko Globokar, as well as Fran Milčinski (a.k.a. Ježek, Laibach, or Bob Dylan; 5 music journalism, from Johann Beer and Louis-Abel Beffroy de Reigny and his popular pieces de circonstance, to nineteenth-century music journalism, George

  14. D. I. BLOKHINTSEV – SCIENTIST AND TEACHER. THE SPIRITUAL FOUNDATIONS OF SCIENTIFIC WORK

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    V. N. Pervushin

    2016-01-01

    Full Text Available The aim of the publication is to state the creative principles of activity of the outstanding scientist and teacher Dmitry Ivanovich Blokhintsev (1/10/1908 – 1/29/1979 – the organizer and the first director of the Joint Institute for Nuclear Researches in Dubna in 1956–1965, one of the pioneers of Nuclear Science and Atomics, the corresponding member of the Academy of Sciences of the USSR.The author of the article shares memories about the teacher and the research supervisor, and gives a peculiar report on realization of ideas of D. I. Blokhintsev. D. I. Blokhintsev had the special, original point of view on spiritual bases of scientific creativity that was directly reflected in his research and pedagogical activity.There are two fundamental aspects of pedagogics. On the one hand, it is the science possessing own specific laws and methods. On the other hand, the pedagogics is an art which methods, unlike scientific methodologies, can’t be acquired by formal and logical schemes. They are broadcast from one personality to another in direct communication. Thus possibly the «correspondence» assimilation of methods of outstanding teachers is inefficient as a rule. Not enough attention in the press is paid to this informal aspect of pedagogics in the view of difficulty of its description and analysis. The discussed D. I. Blokhintsev’s heritage is valuable from positions of the characteristic of pedagogics as arts of creative skill transfer. At first sight, it can seem paradoxical that this part of pedagogics is considered in connection with work in the field of the Quantum Field Theory and Cosmology – one of the most formalized fields of Theoretical Physics. However, the science, as well as pedagogics, considering it from top-level creativity, is becoming some kind of art too.One more important direction of work of D. I. Blokhintsev continued by the author of the publication in the book «Principles of the Quantum Universe» is

  15. Artistic Research on Freedom in Space and Science

    Science.gov (United States)

    Foing, Bernard H.; Schelfhout, Ronald; Gelfand, Dmitry; Van der Heide, Edwin; Preusterink, Jolanda; Domnitch, Evelina

    which light manipulating machines continuously alter the projected image. Development: In order to delve deeper into the subject of freedom in space and science this setup can serve as a vantage point. And it can offer an interactive environment to explore notions of freedom in space and science. The addition of a specific environment around and above the installation, referring to the fabric of space would highly increase the impact it has on an audience. You would then be able to immerse yourself in the world of this settlement, somewhere in outer space. Sound, light and projection screens will orbit the table changing the projections even more. Triggering the imagination with every movement. Results: Freedome has been exhibited at TecArt in Rotterdam, at ILEWG/Artscience day and the Lunar conference at ESTEC in February 2014. The images underneath (courtesy J. Preusterink BH Foing) depict the installation in some ways it can be experienced http://www.youtube.com/watch?v=Qn8DHARrlU (images: Jolanda Preusterink and Bernard Foing, from ILEWG/ESTEC/ArtScience-The Hague workshop Space Science in the Arts) Authors: Ronald Schelfhout, Bernard Foing, Evelina Domnitch, Dmitry Gelfand, Edwin van der Heide, Jolanda Preusterink

  16. A Bilateral U.S. - Russia Contribution to Disaster Risk Reduction in the Asia-Pacific Region

    Science.gov (United States)

    Eichelberger, J. C.; Gordeev, E.; Bratton, J.; Ismail-Zadeh, A.

    2012-12-01

    An accepted principle of disaster risk reduction is that all stakeholders should be engaged in the process. For extreme geophysical events, this almost always means stakeholders in more than one country. Even when the direct impacts on the ground from violent shaking or explosive eruptions are confined to a single country, effects to lives and property may be carried thousands of kilometers from the event source by tsunamis or ash clouds, respectively. The formation of G-EVER recognizes the need for neighbors to join together on disaster risk reduction. There is much to be gained by sharing real-time monitoring data and databases on past extreme events, mapping risks seamlessly across borders, and establishing best practices through sharing of experiences. Each extreme event is a learning opportunity, and the recent lessons have been particularly painful. Our science, while progressing, is still inadequate both in content and in application. There has also been lack of recognition that the "worst case" is indeed possible. Among the various collaborations needed to reduce disaster risk is bilateral collaboration, because borders are obstacles and exist between two countries with rules that have been determined by those countries. Borders are used by all countries for protection of national and economic security. They restrict flow of people, equipment, and information, but not seismic waves, tsunamis, and ash. Even the relatively minor event of sea ice arriving early in Nome, Alaska last fall involved both Russia and the U.S. in a relief effort to bring fuel. It is the responsibility of natural hazard scientists and crisis managers to work together across borders, and where necessary make the case to their governments for sharing of data and information based on an expanded view of national security. The Bilateral Presidential Commission initiated by U.S. President Barrack Obama and Russian President Dmitry Medvedev has provided a framework in which to expand

  17. Theory and practice of population policies in the Soviet Union

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    V. V. Elizarov

    2017-01-01

    Full Text Available The aim of the research, presented in the paper is the analysis for the formation and development of the basic theory of population policies in the scientific school of Professor Dmitry I.Valentey (Lomonosov Moscow State University. The research was dedicated to the 50th anniversary of the Population Chair of Economics Faculty of Lomonosov Moscow State University. The graduates of the Chair worked and continue to work actively in the field of fundamental and applied research in demography, demographic education, ministries and departments of the socio-economic unit.The works of the 1960s – early 90s (monographs, collections of scientific articles, tutorials, which dealt with the concepts and their interrelationships, approaches to understanding the ratio of social policy, population and demographic policies, the structure of these important components of social policy served as the basis for the analysis. In the study the comparative analysis of the positions of different authors has been made, including other research schools, discussion issues are highlighted, relating to the implementation of the population policies. This article shows the realization of the idea of an interdisciplinary approach to the study of problems of population management in practice, including the studies and discussions of representatives of different sciences (demographers, sociologists, historians, economists, geographers, lawyers, etc..In the final part of the paper the practical steps are considered to enhance the population policy in the USSR in the early 80s, regional peculiarities of the phased introduction of new measures to provide state support for families with children in 1981–1983, as well as approaches to development of regional programmes of population policies in the late 70’s and 80’s.The research has received a new analytical material that reveals the attitude on the definition and content of the basic concepts (demographic policy and

  18. In vitro toxicity of FemOn, FemOn-SiO2 composite, and SiO2-FemOn core-shell magnetic nanoparticles

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    Toropova YG

    2017-01-01

    Full Text Available Yana G Toropova,1 Alexey S Golovkin,2 Anna B Malashicheva,3,4 Dmitry V Korolev,5,6 Andrey N Gorshkov,7 Kamil G Gareev,8 Michael V Afonin,9 Michael M Galagudza10,11 1Laboratory of Cardioprotection, Institute of Experimental Medicine, Federal Almazov North-West Medical Research Centre, Saint Petersburg, Russian Federation; 2Gene and Cell Engineering Group, Institute of Molecular Biology and Genetics, Federal Almazov North-West Medical Research Centre, Saint Petersburg, Russian Federation; 3Laboratory of Molecular Cardiology, Institute of Molecular Biology and Genetics, Federal Almazov North-West Medical Research Centre, Saint Petersburg, Russian Federation; 4Department of Embryology, Faculty of Biology, Saint Petersburg State University, Saint Petersburg, Russian Federation; 5Laboratory of Nanotechnology, Institute of Experimental Medicine, Federal Almazov North-West Medical Research Centre, Saint Petersburg, Russian Federation; 6Department of Photonics and Optical Information Technology ITMO University, Saint Petersburg, Russian Federation; 7Laboratory of Intracellular Signaling and Transport Research Institute of Influenza, Saint Petersburg, Russian Federation; 8Department of Micro and Nanoelectronics, Faculty of Electronics, Saint Petersburg Electrotechnical University LETI, Saint Petersburg, Russian Federation; 9Department of Inorganic Chemistry Saint Petersburg State Technological Institute (Technical University, Saint Petersburg, Russian Federation; 10Institute of Experimental Medicine, Federal Almazov North-West Medical Research Centre, Saint Petersburg, Russian Federation; 11Departament of Pathophysiology, First Pavlov State Medical University of Saint Petersburg, Saint Petersburg, Russian Federation Abstract: Over the last decade, magnetic iron oxide nanoparticles (IONPs have drawn much attention for their potential biomedical applications. However, serious in vitro and in vivo safety concerns continue to exist. In this study, the effects

  19. Femoral nerve blockade using various concentrations of local anesthetic for knee arthroscopy in the pediatric population

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    Veneziano G

    2016-11-01

    Full Text Available Giorgio Veneziano,1,2 Jennifer Tripi,1 Dmitry Tumin,1 Mumin Hakim,1 David Martin,1,2 Ralph Beltran,1,2 Kevin Klingele,3,4 Tarun Bhalla,1,2 Joseph D Tobias1,2 1Department of Anesthesiology & Pain Medicine, Nationwide Children’s Hospital, 2Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, 3Department of Orthopedic Surgery, Nationwide Children’s Hospital, 4Department of Orthopedic Surgery, The Ohio State University College of Medicine, Columbus, OH, USA Background: Femoral nerve blockade (FNB provides effective postoperative analgesia in children undergoing arthroscopic knee surgery as evidenced by their opioid-sparing effects and decreased postoperative pain scores. Increasing the local anesthetic concentration in peripheral nerve blockade for adults undergoing orthopedic surgery has been shown to be beneficial, increasing block success rate, and providing a longer duration of analgesia. The effect of increasing the concentration of local anesthetic in extremity blocks in children remains largely unexplored.Methods: We retrospectively evaluated the effectiveness of FNB using three concentrations of local anesthetic (ropivacaine 0.2%, bupivacaine 0.25%, and ropivacaine 0.5% in children and adolescents undergoing arthroscopic knee surgery. The primary outcome evaluated was postoperative opioid consumption before discharge. Secondary outcomes included post-anesthesia care unit (PACU and hospital discharge times, first pain score in PACU, and the incidence of adverse events.Results: Two hundred and sixty-nine children and adolescents who received a FNB for arthroscopic knee surgery from January 2010 to December 2013 were included for analysis. Local anesthetic used in FNB was ropivacaine 0.2% in 116 (43% cases, ropivacaine 0.5% in 75 (28% cases, and bupivacaine 0.25% in 78 (29% cases. Median postoperative opioid consumption (mg/kg intravenous morphine equivalents in the ropivacaine 0.5% group was 0

  20. Andrej Belyj. Sinfonia (2-a, la drammatica. E il tempo scorreva senza sosta…

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    Giuseppina Giuliano

    2016-05-01

    meaning, a satirical meaning, and a symbolic ideological meaning».  The «musical meaning» inspires the author in splitting the Symphony «into parts, the parts into fragments, and the fragments into verses (musical phrases», thus creating a new literary genre, which combines prose and poetry, and emphasizes the mystic, satirical and grotesque content of the work. This mix of prose and poetry is also typical of the novel Petersburg. In the Dramatic Symphony Bely was targeting groups of mystics operating in the early 1900’s in Moscow and Saint Petersburg. He openly mentions or covertly alludes to actual protagonists of the literary, artistic and philosophical Russian society: Vladimir Solovyov (1853-1900, Dmitry Merezhkovsky (1865-1941 and others. Strictly autobiographical themes are presented in form of grotesque and hyperbolic images, alternating with moments of great lyrical tension. The «musical meaning» is also linked to the particular conception of time through which the plot of Bely’s Symphony is developed. At the beginning, a whole day passes by very slowly; then time speeds up and the plot goes through several months and seasons. At the end of the work we are back to where we started, like in a dramatic cycle. This method is well summarized in one of the leitmotive of the work: «And the time flowed without stopping, and the passage of time reflected the Eternity misty».

  1. Preface: SciDAC 2009

    Science.gov (United States)

    Simon, Horst

    2009-07-01

    and posters goes to the teams of researchers, the success of this year's conference is due to the strong efforts and support from members of the 2009 SciDAC Program Committee and Organizing Committee, and I would like to extend my heartfelt thanks to them for helping to make the 2009 meeting the largest and most successful to date. Program Committee members were: David Bader, LLNL; Pete Beckman, ANL; John Bell, LBNL; John Boisseau, University of Texas; Paul Bonoli, MIT; Hank Childs, LBNL; Bill Collins, LBNL; Jim Davenport, BNL; David Dean, ORNL; Thom Dunning, NCSA; Peg Folta, LLNL; Glenn Hammond, PNNL; Maciej Haranczyk, LBNL; Robert Harrison, ORNL; Paul Hovland, ANL; Paul Kent, ORNL; Aram Kevorkian, SPAWAR; David Keyes, Columbia University; Kwok Ko, SLAC; Felice Lightstone, LLNL; Bob Lucas, ISI/USC; Paul Mackenzie, Fermilab; Tony Mezzacappa, ORNL; John Negele, MIT; Jeff Nichols, ORNL; Mike Norman, UCSD; Joe Oefelein, SNL; Jeanie Osburn, NRL; Peter Ostroumov, ANL; Valerio Pascucci, University of Utah; Ruth Pordes, Fermilab; Rob Ross, ANL; Nagiza Samatova, ORNL; Martin Savage, University of Washington; Tim Scheibe, PNNL; Ed Seidel, NSF; Arie Shoshani, LBNL; Rick Stevens, ANL; Bob Sugar, UCSB; Bill Tang, PPPL; Bob Wilhelmson, NCSA; Kathy Yelick, NERSC/LBNL; Dave Zachmann, Vista Computational Technology LLC. Organizing Committee members were: Communications: Jon Bashor, LBNL. Contracts/Logistics: Mary Spada and Cheryl Zidel, ANL. Posters: David Bailey, LBNL. Proceedings: John Hules, LBNL. Proceedings Database Developer: Beth Cerny Patino, ANL. Program Committee Liaison/Conference Web Site: Yeen Mankin, LBNL. Tutorials: David Skinner, NERSC/LBNL. Visualization Night: Hank Childs, LBNL; Valerio Pascucci, Chems Touati, Nathan Galli, and Erik Jorgensen, University of Utah. Again, my thanks to all. Horst Simon San Diego, California June 18, 2009

  2. PREFACE: Ultrathin layers of graphene, h-BN and other honeycomb structures Ultrathin layers of graphene, h-BN and other honeycomb structures

    Science.gov (United States)

    Geber, Thomas; Oshima, Chuhei

    2012-08-01

    nanometer scale. This special section contains interesting papers on graphene, h-BN and related 'honeycomb' compounds on solid surfaces, which are currently in development. Interfacial interaction strongly modifies the electronic and atomic structures of these overlayer systems and substrate surfaces. In addition, one can recognize a variety of growth phenomena by changing the surface and growth conditions, which are promising as regards fabricating those noble nanosystems. We have great pleasure in acknowledging the enthusiastic response and participation of our invited authors and their diligent preparation of the manuscripts. Ultrathin layers of graphene, h-BN and other honeycomb structures contents Ultrathin layers of graphene, h-BN and other honeycomb structuresThomas Geber and Chuhei Oshima Templating of arrays of Ru nanoclusters by monolayer graphene/Ru Moirés with different periodicitiesEli Sutter, Bin Wang, Peter Albrecht, Jayeeta Lahiri, Marie-Laure Bocquet and Peter Sutter Controllable p-doping of graphene on Ir(111) by chlorination with FeCl3N A Vinogradov, K A Simonov, A V Generalov, A S Vinogradov, D V Vyalikh, C Laubschat, N Mårtensson and A B Preobrajenski Optimizing long-range order, band gap, and group velocities for graphene on close-packed metal surfacesF D Natterer, S Rusponi, M Papagno, C Carbone and H Brune Epitaxial growth of graphene on transition metal surfaces: chemical vapor deposition versus liquid phase depositionSamuel Grandthyll, Stefan Gsell, Michael Weinl, Matthias Schreck, Stefan Hüfner and Frank Müller High-yield boron nitride nanosheets from 'chemical blowing': towards practical applications in polymer compositesXuebin Wang, Amir Pakdel, Chunyi Zhi, Kentaro Watanabe, Takashi Sekiguchi, Dmitri Golberg and Yoshio Bando BCx layers with honeycomb lattices on an NbB2(0001) surfaceChuhei Oshima Epitaxial growth of boron-doped graphene by thermal decomposition of B4CWataru Norimatsu, Koichiro Hirata, Yuta Yamamoto, Shigeo Arai and Michiko

  3. Ernst Equation and Riemann Surfaces: Analytical and Numerical Methods

    International Nuclear Information System (INIS)

    Ernst, Frederick J

    2007-01-01

    metric tensor components. The first two chapters of this book are devoted to some basic ideas: in the introductory chapter 1 the authors discuss the concept of integrability, comparing the integrability of the vacuum Ernst equation with the integrability of nonlinear equations of Korteweg-de Vries (KdV) type, while in chapter 2 they describe various circumstances in which the vacuum Ernst equation has been determined to be relevant, not only in connection with gravitation but also, for example, in the construction of solutions of the self-dual Yang-Mills equations. It is also in this chapter that one of several equivalent linear systems for the Ernst equation is described. The next two chapters are devoted to Dmitry Korotkin's concept of algebro-geometric solutions of a linear system: in chapter 3 the structure of such solutions of the vacuum Ernst equation, which involve Riemann theta functions of hyperelliptic algebraic curves of any genus, is contrasted with the periodic structure of such solutions of the KdV equation. How such solutions can be obtained, for example, by solving a matrix Riemann-Hilbert problem and how the metric tensor of the associated spacetime can be evaluated is described in detail. In chapter 4 the asymptotic behaviour and the similarity structure of the general algebro-geometric solutions of the Ernst equation are described, and the relationship of such solutions to the perhaps more familiar multi-soliton solutions is discussed. The next three chapters are based upon the authors' own published research: in chapter 5 it is shown that a problem involving counter-rotating infinitely thin disks of matter can be solved in terms of genus two Riemann theta functions, while in chapter 6 the authors describe numerical methods that facilitate the construction of such solutions, and in chapter 7 three-dimensional graphs are displayed that depict all metrical fields of the associated spacetime. Finally, in chapter 8, the difficulties associated with

  4. PREFACE: XXI International Conference on Spectral Line Shapes (ICSLS 2012)

    Science.gov (United States)

    Devdariani, Alexander Z.

    2012-12-01

    Conference would like to wish him and his colleagues every success for the next conference in Tennessee. The St Petersburg Conference was supported by the grants from St Petersburg State University, the Russian Foundation for Basic Research and Dynasty, Dmitry Zimin's Foundation for Non-Profit Programs. The Organizing Committee would like to thank them for their support. A word of thanks also goes to staff of the Research Department of St Petersburg State University for assistance with administrative issues, and to Mr S Slyusarev for creating the Conference logo and website. I would like to thank personally Professor A Kouzov, and Dr V Alexeev for providing much support in the process of preparing and holding the event in 2012. Alexander Z Devdariani St Petersburg University Conference photograph Sponsors St Petersburg University St Petersburg University Dynasty Foundation Dynasty Foundation Russian Foundation for Basic Research Russian Foundation for Basic Research

  5. Towards A Moon Village: Vision and Opportunities

    Science.gov (United States)

    Foing, Bernard

    2016-04-01

    or interest. Just let us know your views! Highlights and recommendations can be found on https://ildwg.wordpress.com/ *Moon Village Workshops Organisers Team: Bernard Foing (ESA/ESTEC & ILEWG), Aidan Cowley, Guillermo Ortega, Linda van Hilten (ESA), Vid Beldavs, David Dunlop, Jim Crisafulli (International Lunar Decade), ESTEC Moon Village workshop 2015 WGs co-conveners: Peter Batenburg, Andrea Jaime, Abigail Calzada, Angeliki Kapoglou, Chris Welch, Susanne Pieterse, Daniel Esser, Audrey Berquand, Daniel Winter, Dmitri Ivanov, Simone Paternostro, Matias Hazadi, Oscar Kamps, Marloes Offringa

  6. Sensitivity of ocean model simulation in the coastal ocean to the resolution of the meteorological forcing

    Science.gov (United States)

    Chen, Feng; Shapiro, Georgy; Thain, Richard

    2013-04-01

    identifying the causes. The length scales of most energetic dynamic features in both ocean and atmosphere are defined by the Rossby radius of deformation, which is about 1000 km (a typical size of a cyclone) in the atmosphere while only 10-20 km (a size of a mesoscale eddy) in a shallow sea. However sub-mesoscale atmospheric patterns such as patchiness in the cloud cover could result in smaller scale variations of both the wind and solar radiation hence creating a direct link of these smaller atmospheric features with the ocean mesoscale variability. The simulation has been performed using a version of POLCOMS numerical model (Enriquez et al, 2005). Tidal boundary conditions were taken from the Oregon State University European Shelf Tidal Model (Egbert et al, 2010) and the temperature/ salinity initial fields and boundary conditions were taken from the World Ocean Database (Boyer et al, 2004). The paper discusses what elements of the circulation and water column structure are mostly sensitive to the meteo-fields resolution. References Kara, A.B., Wallcraft, A.J., Hurlburt, H.E., Loh, W.-Y., 2009. Which surface atmospheric variable drives the seasonal cycle of sea surface temperature over the global ocean? Journal of Geophysical Research, Vol. 114, D05101. Boyer, .T, S. Levitus, H. Garcia, R. Locarnini, C. Stephens, and J. Antonov, T. Boyer, S. Levitus, H. Garcia, R. Locarnini, C. Stephens, and J. Antonov, 2004. Objective Analyses of Annual, Seasonal, and Monthly Temperature and Salinity for the World Ocean on a ¼ Grid. International Journal of Climatology, 25, 931-945. Egbert, G. D., S. Y. Erofeeva, and R. D. Ray, 2010. Assimilation of altimetry data for nonlinear shallow-water tides: quarter-diurnal tides of the Northwest European Shelf, Continental Shelf Research, 30, 668-679. Enriquez, C. E., G. I. Shapiro, A. J. Souza, and A. G. Zatsepin, 2005. Hydrodynamic modelling of mesoscale eddies in the Black Sea. Ocean Dyn., 55, 476-489. Georgy Shapiro, Dmitry Aleynik , Andrei

  7. List of Participants

    Science.gov (United States)

    2008-11-01

    Mohab Abou ZeidInstitut des Hautes Études Scientifiques, Bures-sur-Yvette Ido AdamMax-Planck-Institut für Gravitationsphysik (AEI), Potsdam Henrik AdorfLeibniz Universität Hannover Mohammad Ali-AkbariIPM, Tehran Antonio Amariti Università di Milano-Bicocca Nicola Ambrosetti Université de Neuchâtel Martin Ammon Max-Planck-Institut für Physik, München Christopher AndreyÉcole Polytechnique Fédérale de Lausanne (EPFL) Laura AndrianopoliPolitecnico di Torino David AndriotLPTHE, Université UPMC Paris VI Carlo Angelantonj Università di Torino Pantelis ApostolopoulosUniversitat de les Illes Balears, Palma Gleb ArutyunovInstitute for Theoretical Physics, Utrecht University Davide AstolfiUniversità di Perugia Spyros AvramisUniversité de Neuchâtel Mirela BabalicChalmers University, Göteborg Foday BahDigicom Ioannis Bakas University of Patras Igor BandosUniversidad de Valencia Jose L F BarbonIFTE UAM/CSIC Madrid Till BargheerMax-Planck-Institut für Gravitationsphysik (AEI), Potsdam Marco Baumgartl Eidgenössische Technische Hochschule (ETH), Zürich James BedfordImperial College London Raphael BenichouLaboratoire de Physique Théorique, École Normale Supérieure, Paris Francesco Benini SISSA, Trieste Eric Bergshoeff Centre for Theoretical Physics, University of Groningen Alice BernamontiVrije Universiteit, Brussel Julia BernardLaboratoire de Physique Théorique, École Normale Supérieure, Paris Adel Bilal Laboratoire de Physique Théorique, École Normale Supérieure, Paris Marco Billo' Università di Torino Matthias Blau Université de Neuchâtel Guillaume BossardAlbert-Einstein-Institut, Golm Leonardo BriziÉcole Polytechnique Fédérale de Lausanne (EPFL) Johannes BroedelLeibniz Universität Hannover (AEI) Tom BrownQueen Mary, University of London Ilka BrunnerEidgenössische Technische Hochschule (ETH), Zürich Erling BrynjolfssonUniversity of Iceland Dmitri BykovSteklov Institute, Moscow and Trinity College, Dublin Joan CampsUniversitat de Barcelona

  8. PREFACE: XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP) (Group30)

    Science.gov (United States)

    Brackx, Fred; De Schepper, Hennie; Van der Jeugt, Joris

    2015-04-01

    Christophe Peeters, Deputy Mayor of the City of Ghent, was followed by a reception in the historical "Pacificatiezaal" of the City Hall. On Wednesday afternoon the participants had the opportunity to take a guided tour through medieval Ghent, admiring its wide range of monuments. The tour was followed by a much-appreciated boat trip exploring the canals and rivers of Ghent, all in sunny weather. On Thursday evening the conference banquet was held in the "Brasserie HA". Located in the Handelsbeurs Ghent. In the majestic banquet hall, the participants were not only treated to an exclusive dinner, but also to some fine piano music by Dmitry Gal'tsov and Richard Kerner. The conference was sponsored by: American Institute of Physics (AIP Publishing), Clay Mathematics Institute, Clifford Research Group - Faculty of Engineering and Architecture (Ghent Unviversity), Elsevier, Faculty of Sciences (Ghent University), Fonds de la Recherche Scientifique (FNRS), Foundation Compositio Mathematica, FWO Research Foundation - Flanders, International Association of Mathematical Physics, International Solvay Institutes, International Union of Pure and Applied Physics, National Science Foundation (USA) and Springer Birkhäuser. We would like to thank all our sponsors for their generous support. It took more than two years to organise a conference of such a size and importance. We express our gratitude to the International Advisory Committee for its help in selecting the plenary speakers and to the external members of the Organising Committee for their helpful suggestions and advice. We thank Wouter Dewolf for his devoted secretarial, administrative and organisational work and Vera Vanden Driessche for arranging the "Accompanying persons' programme". Finally, a big 'thank you' to all the local people (administrative and technical staff, research assistants and research students) for their devoted and tireless work in preparing and running the conference. Fred Brackx, Hennie De Schepper and Joris

  9. EDITORIAL: Ongoing climatic change in Northern Eurasia: justification for expedient research

    Science.gov (United States)

    Groisman, Pavel; Soja, Amber J.

    2009-12-01

    season weather in Kazakhstan C K Wright, K M de Beurs, Z K Akhmadieva, P Y Groisman and G M Henebry Climate change in Inner Mongolia from 1955 to 2005—trends at regional, biome and local scales N Lu, B Wilske, J Ni, R John and J Chen Application of the Snowmelt Runoff model in the Kuban river basin using MODIS satellite images M V Georgievsky Record Russian river discharge in 2007 and the limits of analysis A I Shiklomanov and R B Lammers Paleoclimatic reconstructions for the south of Valdai Hills (European Russia) as paleo-analogs of possible regional vegetation changes under global warming E Novenko, A Olchev, O Desherevskaya and I Zuganova Diagnosis of the record discharge of Arctic-draining Eurasian rivers in 2007 Michael A Rawlins, Mark C Serreze, Ronny Schroeder, Xiangdong Zhang and Kyle C McDonald Studies of the cryosphere in Northern Eurasia Groundwater storage changes in arctic permafrost watersheds from GRACE and in situ measurements Reginald R Muskett and Vladimir E Romanovsky Changes in snow cover over Northern Eurasia in the last few decades O N Bulygina, V N Razuvaev and N N Korshunova Modeling sub-sea permafrost in the East Siberian Arctic Shelf: the Dmitry Laptev Strait D Nicolsky and N Shakhova Snow cover basal ice layer changes over Northern Eurasia since 1966 Olga N Bulygina, Pavel Ya Groisman, Vyacheslav N Razuvaev and Vladimir F Radionov Snow cover and permafrost evolution in Siberia as simulated by the MGO regional climate model in the 20th and 21st centuries I M Shkolnik, E D Nadyozhina, T V Pavlova, E K Molkentin and A A Semioshina Studies of the biosphere in Northern Eurasia The influence of regional surface soil moisture anomalies on forest fires in Siberia observed from satellites A Bartsch, H Balzter and C George Change and persistence in land surface phenologies of the Don and Dnieper river basins V Kovalskyy and G M Henebry Effects of climatic changes on carbon dioxide and water vapor fluxes in boreal forest ecosystems of European part of

  10. Preface: SciDAC 2008

    Science.gov (United States)

    Stevens, Rick

    2008-07-01

    scenes an enormous amount of work is required to make a large conference go smoothly. First I thank Cheryl Zidel for her tireless efforts as organizing committee liaison and posters chair and, in general, handling all of my end of the program and keeping me calm. I also thank Gail Pieper for her work in editing the proceedings, Beth Cerny Patino for her work on the Organizing Committee website and electronic theater, and Ken Raffenetti for his work in keeping that website working. Jon Bashor and John Hules did an excellent job in handling conference communications. I thank Caitlin Youngquist for the striking graphic design; Dan Fay for tutorials arrangements; and Lynn Dory, Suzanne Stevenson, Sarah Pebelske and Sarah Zidel for on-site registration and conference support. We all owe Yeen Mankin an extra-special thanks for choosing the hotel, handling contracts, arranging menus, securing venues, and reassuring the chair that everything was under control. We are pleased to have obtained corporate sponsorship from Cray, IBM, Intel, HP, and SiCortex. I thank all the speakers and panel presenters. I also thank the former conference chairs Tony Metzzacappa, Bill Tang, and David Keyes, who were never far away for advice and encouragement. Finally, I offer my thanks to Michael Strayer, without whose leadership, vision, and persistence the SciDAC program would not have come into being and flourished. I am honored to be part of his program and his friend. Rick Stevens Seattle, Washington July 18, 2008

  11. Towards a Moon Village: Young Lunar Explorers Report

    Science.gov (United States)

    Kamps, Oscar; Foing, Bernard; Batenburg, Peter

    2016-04-01

    : ESA delegations, media, national governments, citizens and taxpayers. References: [1] http://sci.esa.int/ilewg/ and https://ildwg.wordpress.com/ [2] Foing B. Moon explora-tion highlights and Moon Village introduction. [3] Young Lunar Explorers Report ESTEC Moon village sessions with community and young professionals. *Organisation: Bernard Foing, ESA/ESTEC & ILEWG, ESTEC Moon Village workshop WGs co-conveners: Peter Batenburg, Andrea Jaime, Abigail Calzada, Angeliki Kapoglou, Chris Welch, Susanne Pieterse, Daniel Esser, Audrey Berquand, Daniel Winter, Hanna Läkk, Dmitri Ivanov, S Paternostro, Matias Hazadi, Oscar Kamps

  12. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity

    Science.gov (United States)

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.

    2006-04-01

    Cagliari, Italy) Roberto De Pietri (Università di Parma, Italy) Giuseppe De Risi (Università di Bari, Italy) Hans-Thomas Elze (Univ. Federal do Rio de Janeiro, Brasil) Alessandro Fabbri (Università di Bologna, Italy) Sergey Fadeev (VNIIMS, Moscow, Russia) Serena Fagnocchi (Università di Bologna, Italy) Sara Farese (Universidad de Valencia, Spain) Alessandra Feo (Università di Parma, Italy) Dario Francia (Università di Roma Tor Vergata, Italy) Francesco Fucito (Università di Roma Tor Vergata, Italy) Dmitri Fursaev (JINR, Dubna, Russia) Daniel Galehouse (University of Akron, Ohio, USA) Remo Garattini (Università di Bergamo, Italy) Florian Girelli (Perimeter Institute, Waterloo, Canada) Luca Griguolo (Università di Parma, Italy) Daniel Grumiller (Universität Leipzig, Germany) Shinichi Horata (Hayama Center of Advanced Research, Japan) Giorgio Immirzi (Università di Perugia, Italy) Roman Jackiw (MIT, Cambridge, USA) Matyas Karadi (DAMTP, University of Cambridge, UK) Mikhail Katanaev (Steklov Mathematical Institute, Moscow, Russia) Claus Kiefer (Universität Koln, Germany) John Klauder (University of Florida, Gainesville, USA) Pavel Klepac (Masaryk University, Brno, Czech Republic) Jen-Chi Lee (National Chiao-Tung University, Taiwan) Carlos Leiva (Universidad de Tarapacá, Arica, Chile) Stefano Liberati (SISSA/ISAS, Trieste, Italy) Jorma Louko (University of Nottingham, UK) Luca Lusanna (INFN, Sezione di Firenze, Italy) Roy Maartens (University of Portsmouth, UK) Fotini Markopoulou (Perimeter Institute, Waterloo, Canada) Annalisa Marzuoli (Università di Pavia, Italy) Evangelos Melas (QMW, University of London, UK) Maurizio Melis (Università di Cagliary, Italy) Vitaly Melnikov (VNIIMS, Moscow, Russia) Guillermo A. Mena Marugan (CSIC, Madrid, Spain) Pietro Menotti (Università di Pisa, Italy) Salvatore Mignemi (Università di Cagliari, Italy) Aleksandar Mikovic (Universidade Lusófona, Lisboa, Portugal) Leonardo Modesto (Université de la Mediterranée, Marseille

  13. List of Participants

    Science.gov (United States)

    2007-11-01

    de Física Teórica, Madrid Aaron Sim Imperial College, London Woojoo Sim Pohang University of Science and Technology (POSTECH) Sergey Slizovskiy Department of Theoretical Physics, Uppsala University Paul Smyth Katholieke Universiteit Leuven Corneliu Sochichiu Laboratori Nazionali di Frascati Dmitri Sorokin Istituto Nazionale di Fisica Nucleare, Padova Kellogg Stelle Imperial College, London Piotr Surowka Jagiellonian University, Krakow Yasutoshi Takayama Niels Bohr Institute, København Laura Tamassia Katholieke Universiteit Leuven Radu Tatar University of Liverpool Larus Thorlacius University of Iceland Paavo Tiitola Helsinki Institute of Physics Diego Trancanelli Stony Brook University, NY Michele TraplettiInstitut für Theoretische Physik, Universität Heidelberg Mario Trigiante Politecnico di Torino Angel Uranga CERN, Geneva and Instituto de Física Teórica, Madrid Roberto Valandro SISSA, Trieste Dieter Van den Bleeken Katholieke Universiteit Leuven Antoine Van Proeyen Katholieke Universiteit Leuven Thomas Van Riet Centre for Theoretical Physics, University of Groningen Pierre Vanhove Service de Physique Théorique, Saclay Oscar Varela Universidad de Valencia Alessandro Vichi Scuola Normale Superiore di Pisa Massimiliano VinconQueen Mary, University of London John Ward Queen Mary, University of London and CERN, Geneva Brian Wecht Massachusetts Institute of Technology, Cambridge, MA Marlene Weiss Eidgenössische Technische Hochschule, Zürich and CERN, Geneva Sebastian Weiss Université de Neuchâtel Alexander Wijns Vrije Universiteit, Brussel Przemek Witaszczyk Jagiellonian University, Krakow Timm Wrase University of Texas at Austin Jun-Bao Wu SISSA, Trieste Amos Yarom Ludwig-Maximilians-Universität, München Marco Zagermann Max-Planck-Institut für Physik, München Daniela Zanon Dipartimento di Fisica, Università di Milano Andrea Zanzi University of Bonn Andrey Zayakin Moscow State University (MSU) and Institute for Theoretical and Experimental Physics (ITEP

  14. EDITORIAL: Colloidal dispersions in external fields Colloidal dispersions in external fields

    Science.gov (United States)

    Löwen, Hartmut

    2012-11-01

    , Ojeda-Lopez M A and Arauz-Lara J L 2012 J. Phys. Condens. Matter 24 464126 [31]Leferink op Reinink A B G M, van den Pol E, Byelov D V, Petukhov A V and Vroege G J 2012 J. Phys. Condens. Matter 24 464127 [32]Taylor S L, Evans R and Royall C P 2012 J. Phys. Condens. Matter 24 464128 [33]Toner J, Tu Y H and Ramaswamy S 2012 J. Phys. Condens. Matter 24 464110 [34]Schmitz R and Dünweg B 2005 J. Phys. Condens. Matter 318 170 [35]Cates M E 2012 Rep. Prog. Phys. 75 042601 [36]Tarama M and Ohta T 2012 J. Phys. Condens. Matter 24 464129 [37]Wensink H H and Löwen H 2012 J. Phys. Condens. Matter 24 464130 Colloidal dispersions in external fields contents Colloidal dispersions in external fieldsHartmut Löwen Depletion induced clustering in mixtures of colloidal spheres and fd-virusD Guu, J K G Dhont, G A Vliegenthart and M P Lettinga Advanced rheological characterization of soft colloidal model systemsS Gupta, S K Kundu, J Stellbrink, L Willner, J Allgaier and D Richter Conformational and dynamical properties of ultra-soft colloids in semi-dilute solutions under shear flowSunil P Singh, Dmitry A Fedosov, Apratim Chatterji, Roland G Winkler and Gerhard Gompper Transient dynamics in dense colloidal suspensions under shear: shear rate dependenceM Laurati, K J Mutch, N Koumakis, J Zausch, C P Amann, A B Schofield, G Petekidis, J F Brady, J Horbach, M Fuchs and S U Egelhaaf Force-induced diffusion in microrheologyCh J Harrer, D Winter, J Horbach, M Fuchs and Th Voigtmann Micro-macro-discrepancies in nonlinear microrheology: I. Quantifying mechanisms in a suspension of Brownian ellipsoidsRyan J DePuit and Todd M Squires Micro-macro discrepancies in nonlinear microrheology: II. Effect of probe shapeRyan J DePuit and Todd M Squires Viscosity of electrolyte solutions: a mode-coupling theoryClaudio Contreras-Aburto and Gerhard Nägele Electro-kinetics of charged-sphere suspensions explored by integral low-angle super-heterodyne laser Doppler velocimetryThomas Palberg, Tetyana K