Diagnostics of vascular diseases as a cause for acute abdomen; Diagnostik vaskulaerer Erkrankungen als Ursache fuer das akute Abdomen

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Juchems, M.S. [Universitaetsklinikum Ulm, Klinik fuer Diagnostische und Interventionelle Radiologie, Ulm (Germany); Aschoff, A.J. [Klinikum Kempten-Oberallgaeu, Abteilung fuer Radiologie, Kempten (Germany)

2010-03-15

Vascular pathologies are rare causes of an acute abdomen. If the cause is a vascular disease a rapid diagnosis is desired as vascular pathologies are associated with high mortality. A differentiation must be made between arterial and venous diseases. An occlusion of the superior mesenteric artery is the most common reason for acute mesenteric ischemia but intra-abdominal arterial bleeding is also of great importance. Venous pathologies include thrombotic occlusion of the portal vein, the mesenteric vein and the vena cava. Multi-detector computed tomography (MDCT) is predestined for the diagnostics of vascular diseases of the abdomen. Using multiphasic contrast protocols enables reliable imaging of the arterial and venous vessel tree and detection of disorders with high sensitivity and specificity. Although conventional angiography has been almost completely replaced by MDCT as a diagnostic tool, it is still of high importance for minimally invasive interventions, for example in the management of gastrointestinal bleeding. (orig.) [German] Vaskulaere Pathologien sind seltene Ursachen fuer den klinischen Zustand eines akuten Abdomens. Liegt eine vaskulaere Erkrankung vor, ist jedoch aufgrund der hohen Mortalitaet eine zuegige Diagnostik von grosser Wichtigkeit. Bei den Erkrankungen der abdominellen Gefaesse sind arterielle von venoesen Ursachen zu unterscheiden. Ein Verschluss der A. mesenterica superior ist die haeufigste Ursache fuer die akute Mesenterialischaemie, daneben sind Blutungen in den abdominellen Gefaessprovinzen des arteriellen Gefaessbaums von Bedeutung. Venoese Pathologien betreffen thrombotische Verschluesse der Pfortader, der V. mesenterica und der V. cava. Die Multidetektor-CT (MDCT) ist zur Diagnostik vaskulaerer Erkrankungen des Abdominalraums praedestiniert. Mit mehrphasigen Untersuchungsprotokollen gelingt es, den arteriellen und venoesen Gefaessbaum zuverlaessig darzustellen und Erkrankungen mit hoher Sensitivitaet und Spezifitaet zu

Assessment of endocrine disorders of the hypothalamic-pituitary axis by nuclear medicine techniques; Nuklearmedizinische Verfahren zur Abklaerung endokrinologischer Erkrankungen der Hypothalamus-Hypophysen-Achse

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Schmidt, M.; Theissen, P.; Dietlein, M.; Schicha, H. [Koeln Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Jackenhoevel, F.; Krone, W. [Koeln Univ. (Germany). Klinik II fuer Innere Medizin

2002-04-01

The following article reviews nuclear medicine techniques which can be used for assessment of endocrine disorders of the hypothalamic-pituitary axis. For planar and SPECT imaging somatostatin-receptor- and dopamine-D2-receptor-scintigraphy are the most widely distributed techniques. These nuclear medicine techniques may be indicated in selected cases to answer differential diagnostic problems. They can be helpful to search for presence and localization of receptor positive tissue. Furthermore they can detect metastasis in the rare cases of a pituitary carcinoma. Scintigraphy with Gallium-67 is suitable for further diagnostic evaluation in suspected hypophysitis. Other SPECT radiopharmaca do not have relevant clinical significance. F-18-FDG as PET radiopharmacon is not ideal because obvious pituitary adenomas could not be visualized. Other PET radiopharmaca including C-11-methionine, C-11-tyrosine, F-18-fluoroethylspiperone, C-11-methylspiperone, and C-11-raclopride are available in specialized centers only. Overall indications for nuclear medicine in studies for the assessment of endocrine disorders of the hypothalamic-pituitary-axis are rare. Original studies often report only about a small number of patients. According to the authors' opinion the relevance of nuclear medicine in studies of clinically important endocrinologic fields, e. g. localization of small ACTH-producing pituitary adenomas, tumor localization in ectopic ACTH syndrome, localization of recurrent pituitary tissue, assessment of small incidentalomas, can not be definitely given yet. (orig.) [German] Diese Uebersichtsarbeit fasst die nuklearmedizinischen Untersuchungsverfahren zur Abklaerung endokrinologischer Erkrankungen der Hypothalamus-Hypophysen-Achse zusammen. Bei den planaren und SPECT-Unter suchungen sind Somatostatin-Rezeptor- und Dopamin-D2-Rezeptor-Szintigraphie die verbreitetsten Untersuchungstechniken. Im Einzelfall sind sie zur Differenzialdiagnostik, zum Nachweis und zur

Interaktionen des humanpathogenen Pilzes Aspergillus fumigatus mit dem angeborenen Immunsystem und Thrombozyten

OpenAIRE

Czakai, Kristin Bernadette

2015-01-01

Pilze sind in unserer Umwelt allgegenwärtig und besiedeln im Fall von Candida albicans (C. albicans) sogar bei über 50% der Menschen die Schleimhäute, während Sporen von Aspergillus fumigatus (A. fumigatus) täglich über die Atmung in die Lunge des Menschen gelangen. Dennoch sind Erkrankungen, die durch diese zwei Pilze ausgelöst werden, bei gesunden Menschen selten. Ist jedoch das Immunsystem beeinträchtigt, können diese Pilze zu systemischen und damit lebensbedrohlichen Erkrankungen wie der ...

DEGRO practical guidelines for the radiotherapy of non-malignant disorders. Pt. IV. Symptomatic functional disorders

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Reinartz, Gabriele; Eich, Hans Theodor [University Hospital Muenster, Department of Radiation Oncology, Muenster (Germany); Pohl, Fabian [University Hospital Regensburg, Department of Radiotherapy, Regensburg (Germany); Collaboration: German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD)

2015-04-01

, Dosisempfehlungen und Empfehlungen zur Durchfuehrung der Radiotherapie zusammengefasst. Fuer beide Entitaeten (HO, EO) wurde in zahlreichen retrospektiven und einigen prospektiven Untersuchungen ein bemerkenswerter Effekt der Niedrigdosis-Radiotherapie im Sinne einer Symptomreduktion beschrieben. Je nach Entitaet wurden verschiedene Evidenzlevel (LoE) festgestellt, so dass unterschiedliche Empfehlungsgrade (GR) fuer den Einsatz der Radiotherapie ausgesprochen wurden: LoE 1-2 und GR A-B (HO), LoE 2 und GR B (EO). Die Niedrigdosis-Radiotherapie von benignen symptomatischen funktionellen Erkrankungen ist nach Ansicht verschiedener Autoren bei einem Anteil von 25-100 % der untersuchten Patienten effektiv und ist eine gut begruendbare Therapieoption fuer Patienten, bei denen konservative oder operative Verfahren zu keiner anhaltenden Verbesserung gefuehrt haben. Fuer die HO wird die Einzeitbestrahlung mit 7-8 Gy oder die fraktionierte Bestrahlung mit 5 x 3,5 Gy empfohlen. Fuer die EO werden Einzeldosen von 0,3-2,0 Gy und Gesamtdosen von 2,4-20 Gy/Serie mit taeglicher Bestrahlung befuerwortet. (orig.)

Peritoneum and mesenterium. Radiological anatomy and extent of peritoneal diseases; Peritoneum und Mesenterium. Radiologische Anatomie und Ausbreitungswege intraabdomineller Erkrankungen

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Ba-Ssalamah, A.; Bastati, N.; Uffmann, M.; Schima, W. [Medizinische Universitaet Wien (Austria). Universitaetsklinik fuer Radiodiagnostik; Pretterklieber, M. [Zentrum fuer Anatomie und Zellbiologie, Medizinische Universitaet Wien (Austria)

2009-06-15

The abdominal cavity is subdivided into the peritoneal cavity, lined by the parietal peritoneum, and the extraperitoneal space. It extends from the diaphragm to the pelvic floor. The visceral peritoneum covers the intraperitoneal organs and part of the pelvic organs. The parietal and visceral layers of the peritoneum are in sliding contact; the potential space between them is called the peritoneal cavity and is a part of the embryologic abdominal cavity or primitive coelomic duct. To understand the complex anatomical construction of the different variants of plicae and recesses of the peritoneum, an appreciation of the embryologic development of the peritoneal cavity is crucial. This knowledge reflects the understanding of the peritoneal anatomy, deep knowledge of which is very important in determining the cause and extent of peritoneal diseases as well as in decision making when choosing the appropriate therapeutic approach, whether surgery, conservative treatment, or interventional radiology. (orig.) [German] Die Bauchhoehle wird in die von Bauchfell (Peritoneum parietale) ausgekleidete Peritonealhoehle und den extraperitonealen Raum unterteilt. Topographisch unterscheidet man den eigentlichen Bauchraum, das Abdomen und die Beckenhoehle. Das Peritoneum ueberzieht mit einem viszeralen Blatt, Peritoneum viscerale, die intraperitonealen Bauch- und Teile der Beckenorgane. Zwischen Peritoneum parietale und viscerale liegt die als Teil der embryonalen Leibeshoehle entstandene Bauchhoehle. Zum Verstaendnis des Bauchfellverlaufs muessen die Entwicklungsvorgaenge in der Bauchhoehle bekannt sein. Eine profunde Kenntnis dieser unterschiedlichen Raeume und deren Begrenzungen ist wichtig, um die Ausbreitung von Infektionen und Neoplasien bzw. die Genese verschiedener Erkrankungen zu verstehen. Sie ermoeglich es dem Radiologen, im Zusammenhang mit der klinischen Anamnese und den charakteristischen Bildgebungsmerkmalen die Differenzialdiagnose moeglicher Ursachen zu finden und

MRI of the fetal abdomen; MRT des fetalen Abdomens

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Hoermann, M.; Brugger, P.C.; Witzani, L.; Prayer, D. [Medizinische Universitaet Wien (Austria). Universitaetsklinik fuer Radiodiagnostik

2006-02-15

Magnetic resonance imaging (MRI) is an important diagnostic component for central nervous system and thoracic diseases during fetal development. Although ultrasound remains the method of choice for observing the fetus during pregnancy, fetal MRI is being increasingly used as an additional technique for the accurate diagnosis of abdominal diseases. Recent publications confirm the value of MRI in the diagnosis of fetal gastrointestinal tract and urogenital system diseases. The following report provides an overview of MRI-examination techniques for the most frequent diseases of the abdomen. (orig.) [German] Die MRT ist ein wichtiger Bestandteil zur Diagnostik des zentralen Nervensystems und thorakaler Erkrankungen in der fetalen Entwicklung. Wenngleich der Ultraschall die Methode der Wahl zur Ueberwachung des Feten in der Schwangerschaft bleibt, bekommt die fetale MRT als zusaetzliche Untersuchungstechnik zur akkuraten Diagnostik abdomineller Erkrankungen immer groessere Bedeutung. Die neueren Publikationen bestaetigen v. a. den Stellenwert der MRT in der Diagnose von Erkrankungen des fetalen Gastrointestinaltrakts und des Urogenitalsystems. Im Folgenden soll ein Ueberblick ueber die MR-Untersuchungstechnik der haeufigsten Erkrankungen des Abdomens gegeben werden. (orig.)

Mucorales-Specific T Cells in Patients with Hematologic Malignancies.

Science.gov (United States)

Potenza, Leonardo; Vallerini, Daniela; Barozzi, Patrizia; Riva, Giovanni; Gilioli, Andrea; Forghieri, Fabio; Candoni, Anna; Cesaro, Simone; Quadrelli, Chiara; Maertens, Johan; Rossi, Giulio; Morselli, Monica; Codeluppi, Mauro; Mussini, Cristina; Colaci, Elisabetta; Messerotti, Andrea; Paolini, Ambra; Maccaferri, Monica; Fantuzzi, Valeria; Del Giovane, Cinzia; Stefani, Alessandro; Morandi, Uliano; Maffei, Rossana; Marasca, Roberto; Narni, Franco; Fanin, Renato; Comoli, Patrizia; Romani, Luigina; Beauvais, Anne; Viale, Pier Luigi; Latgè, Jean Paul; Lewis, Russell E; Luppi, Mario

2016-01-01

Invasive mucormycosis (IM) is an emerging life-threatening fungal infection. It is difficult to obtain a definite diagnosis and to initiate timely intervention. Mucorales-specific T cells occur during the course of IM and are involved in the clearance of the infection. We have evaluated the feasibility of detecting Mucorales-specific T cells in hematological patients at risk for IM, and have correlated the detection of such cells with the clinical conditions of the patients. By using an enzyme linked immunospot assay, the presence of Mucorales-specific T cells in peripheral blood (PB) samples has been investigated at three time points during high-dose chemotherapy for hematologic malignancies. Mucorales-specific T cells producing interferon-γ, interleukin-10 and interleukin-4 were analysed in order to detect a correlation between the immune response and the clinical picture. Twenty-one (10.3%) of 204 patients, accounting for 32 (5.3%) of 598 PB samples, tested positive for Mucorales-specific T cells. Two groups could be identified. Group 1, including 15 patients without signs or symptoms of invasive fungal diseases (IFD), showed a predominance of Mucorales-specific T cells producing interferon-gamma. Group 2 included 6 patients with a clinical picture consistent with invasive fungal disease (IFD): 2 cases of proven IM and 4 cases of possible IFD. The proven patients had significantly higher number of Mucorales-specific T cells producing interleukin-10 and interleukin-4 and higher rates of positive samples by using derived diagnostic cut-offs when compared with the 15 patients without IFD. Mucorales-specific T cells can be detected and monitored in patients with hematologic malignancies at risk for IM. Mucorales-specific T cells polarized to the production of T helper type 2 cytokines are associated with proven IM and may be evaluated as a surrogate diagnostic marker for IM.

Mucorales-Specific T Cells in Patients with Hematologic Malignancies.

Directory of Open Access Journals (Sweden)

Leonardo Potenza

Full Text Available Invasive mucormycosis (IM is an emerging life-threatening fungal infection. It is difficult to obtain a definite diagnosis and to initiate timely intervention. Mucorales-specific T cells occur during the course of IM and are involved in the clearance of the infection. We have evaluated the feasibility of detecting Mucorales-specific T cells in hematological patients at risk for IM, and have correlated the detection of such cells with the clinical conditions of the patients.By using an enzyme linked immunospot assay, the presence of Mucorales-specific T cells in peripheral blood (PB samples has been investigated at three time points during high-dose chemotherapy for hematologic malignancies. Mucorales-specific T cells producing interferon-γ, interleukin-10 and interleukin-4 were analysed in order to detect a correlation between the immune response and the clinical picture. Twenty-one (10.3% of 204 patients, accounting for 32 (5.3% of 598 PB samples, tested positive for Mucorales-specific T cells. Two groups could be identified. Group 1, including 15 patients without signs or symptoms of invasive fungal diseases (IFD, showed a predominance of Mucorales-specific T cells producing interferon-gamma. Group 2 included 6 patients with a clinical picture consistent with invasive fungal disease (IFD: 2 cases of proven IM and 4 cases of possible IFD. The proven patients had significantly higher number of Mucorales-specific T cells producing interleukin-10 and interleukin-4 and higher rates of positive samples by using derived diagnostic cut-offs when compared with the 15 patients without IFD.Mucorales-specific T cells can be detected and monitored in patients with hematologic malignancies at risk for IM. Mucorales-specific T cells polarized to the production of T helper type 2 cytokines are associated with proven IM and may be evaluated as a surrogate diagnostic marker for IM.

Degenerative cerebellar diseases and differential diagnoses; Degenerative Kleinhirnerkrankungen und Differenzialdiagnosen

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Reith, W.; Roumia, S.; Dietrich, P. [Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg/Saar (Germany)

2016-11-15

Cerebellar syndromes result in distinct clinical symptoms, such as ataxia, dysarthria, dysmetria, intention tremor and eye movement disorders. In addition to the medical history and clinical examination, imaging is particularly important to differentiate other diseases, such as hydrocephalus and multi-infarct dementia from degenerative cerebellar diseases. Degenerative diseases with cerebellar involvement include Parkinson's disease, multiple system atrophy as well as other diseases including spinocerebellar ataxia. In addition to magnetic resonance imaging (MRI), nuclear medicine imaging investigations are also helpful for the differentiation. Axial fluid-attenuated inversion recovery (FLAIR) and T2-weighted sequences can sometimes show a signal increase in the pons as a sign of degeneration of pontine neurons and transverse fibers in the basilar part of the pons. The imaging is particularly necessary to exclude other diseases, such as normal pressure hydrocephalus (NPH), multi-infarct dementia and cerebellar lesions. (orig.) [German] Klinisch imponieren Kleinhirnsyndrome durch Ataxie, Dysarthrie, Dysmetrie, Intentionstremor und Augenbewegungsstoerungen. Neben der Anamnese und klinischen Untersuchung ist die Bildgebung v. a. wichtig um andere Erkrankungen wie Hydrozephalus und Multiinfarktdemenz von degenerativen Kleinhirnerkrankungen zu differenzieren. Zu den degenerativen Erkrankungen mit Kleinhirnbeteiligung gehoeren der Morbus Parkinson, die Multisystematrophie sowie weitere Erkrankungen einschliesslich der spinozerebellaeren Ataxien. Neben der MRT sind auch nuklearmedizinische Untersuchungen zur Differenzierung hilfreich. Axiale Fluid-attenuated-inversion-recovery(FLAIR)- und T2-gewichtete Sequenzen koennen mitunter eine Signalsteigerung im Pons als Ausdruck einer Degeneration der pontinen Neuronen und transversalen Bahnen im Brueckenfuss zeigen. Die Bildgebung ist aber v. a. notwendig, um andere Erkrankungen wie Normaldruckhydrozephalus

Diseases of the hepatobiliary system as a cause of acute abdomen; Erkrankungen des hepatobiliaeren Systems als Ursache des akuten Abdomens

Energy Technology Data Exchange (ETDEWEB)

Schima, W.; Eisenhuber-Stadler, E. [Krankenhaus Goettlicher Heiland, Abteilung fuer Radiologie und bildgebende Diagnostik, Wien (Austria); Koelblinger, C.; Kulinna-Cosentini, C.; Ba-Ssalamah, A. [Medizinische Universitaet Wien, Universitaetsklinik fuer Radiodiagnostik, Wien (Austria)

2010-03-15

Diseases of the liver and biliary system are common causes of acute abdominal pain and gallstone disease predisposes to cholecystitis and cholangiolithiasis. Sonography is the method of choice for the assessment of cholecystitis, whereas magnetic resonance cholangiopancreaticography (MRCP) is the standard technique to detect stones in the common bile duct. Multi-detector computed tomography (MDCT) is ideal for detection of associated complications, including abscess formation and gall stone ileus. Pyogenic, amebic and fungal liver abscesses are reliably diagnosed with MDCT which can also be used for interventional radiologic therapy of liver abscesses by percutaneous aspiration or drainage procedures. The second most common cause of liver rupture after blunt trauma is spontaneous rupture of hypervascular liver tumors (i.e., HCC, adenoma, angiosarcoma) and due to medical procedures. Multi-phase contrast-enhanced MDCT can reliably detect active bleeding to guide further therapy in these cases. (orig.) [German] Die Cholezystitis ist eine der haeufigsten Ursachen fuer ein akutes Abdomen. Waehrend die Sonographie die Methode der Wahl zum Nachweis einer Cholezystolithiasis und Cholezystitis ist, steht bei der Entwicklung von Komplikationen die Multidetektorcomputertomographie (MDCT) diagnostisch im Vordergrund. Die Magnetresonanzcholangiopankreatikographie (MRCP) hat einen hohen Stellenwert bei der Abklaerung der Cholangiolithiasis, v. a. bei der Differenzialdiagnose zu anderen Ursachen einer Cholestase. Die Diagnose bakterieller, Amoeben- oder fungaler Leberabszesse kann mittels Sonographie oder MDCT rasch gestellt werden, wobei diese Methoden auch fuer die interventionelle radiologische Therapie von Leberabszessen (Punktion oder Drainage) gut geeignet sind. Die mehrphasige, kontrastmittelverstaerkte MDCT ist die Methode der Wahl fuer den Nachweis von Leberinfarkten oder -rupturen, da bei diesen Erkrankungen bzw. Verletzungsfolgen die Darstellung der

Papers read at the 13th symposium on neuroradiological contrast media, April 3-5, 1992, Fulda; Vortraege des 13. Neuroradiologischen Kontrastmittelsymposiums, 3.-5. April 1992 Fulda

Energy Technology Data Exchange (ETDEWEB)

Nadjmi, M [ed.; Hacker, H [ed.; Sartor, K [ed.; Voigt, K [ed.

1993-05-01

In recent years, NMR imaging has become a most important tool for the diagnosis of central nervous disorders in children. Using this non-invasive method, which also obviates the need for ionizing rays, it was possible to gain entirely new insights into certain types of neuropaediatric diseases. The particular role of NMR imaging in the assessment of such changes hence was the topic discussed at the 13th Symposium of Neuroradiological Contrast Media. The special journal offers a choice of the papers read on that occasion, among them contributions on methods of anaesthesia used in NMR imaging, on gadolinium DTPA, the physiological development of the infantile brain, congenital malformations and disorders, neurodegenerative and inflammatory diseases, malformations developing during childhood as well as on the limitations that NMR imaging was found to have in the fields of neuropaediatrics and neuropathology. (orig./VHE) [Deutsch] Die Kernspintomographie hat in den letzten Jahren eine wesentliche Bedeutung fuer die Diagnostik von Erkrankungen des Zentralnervensystems im Kindesalter erlangt. Mit Hilfe dieser nicht invasiven und ohne ionisierende Strahlung arbeitenden Methode konnten voellig neue Erkenntnisse ueber bestimmte neuropaediatrische Krankheitsbilder gewonnen werden. Die Kernspintomographie neuropaediatrischer Erkrankungen war daher Gegenstand des 13. Neuroradiologischen Kontrastmittelsymposiums. Im vorliegenden Heft wird eine Auswahl der zu diesem Thema gehaltenen Vortraege veroeffentlicht, die sich u.a. mit Anaesthesie bei kernspintomographischen Untersuchungen, Gadolinium-DTPA, der normalen Reifung des kindlichen Gehirns, angeborenen Missbildungen und Krankheiten, neurodegenerativen und entzuendlichen Erkrankungen und Missbildungen im Kindesalter sowie den Grenzen der Kernspintomographie in der Neuropaediatrie und -pathologie beschaeftigen. (orig./VHE)

MR arthrography of the shoulder: possible indications for clinical use; Einsatzmoeglichkeiten der MR-Arthrographie bei Erkrankungen des Schultergelenkes

Energy Technology Data Exchange (ETDEWEB)

Kreitner, K.F. [Mainz Univ. (Germany). Klinik mit Poliklinik fuer Radiologie; Grebe, P. [Mainz Univ. (Germany). Klinik mit Poliklinik fuer Radiologie; Kersjes, W. [Mainz Univ. (Germany). Klinik mit Poliklinik fuer Radiologie; Runkel, M. [Mainz Univ. (Germany). Klinik fuer Unfallchirurgie; Kirschner, P. [Elisabeth-Hospital, Mainz (Germany). Abt. fuer Unfall- und Wiederherstellungschirurgie St. Vincenz; Schild, H.H. [Mainz Univ. (Germany). Klinik mit Poliklinik fuer Radiologie

1994-02-01

In a prospective study possible indications for MR arthrography of the shoulder were evaluated. 37 patients were examined before and after intraarticular administration of a 2-mmolar solution of Gd-DTPA. MR arthrography was performed if there was no joint effusion and/or an uncertain finding concerning the rotator cuff or the capsulolabral complex on plain MR images. MR arthrography leads to a better demonstration of labrum pathology in 11/22 patients and to a superior delineation of the capsuloligamentous apparatus in 20/22 cases. In 9/15 patients with impingement lesions MR arthrography allowed a differentiation of severe tendinitis from partial and small full-thickness tears of the rotator cuff. MR arthrography of the shoulder joint enhances the accuracy of MR in case of an uncertain finding on plain MR images. (orig.) [Deutsch] In einer prospektiven Studie sollten Einsatzmoeglichkeiten der MR-Arthrographie bei Erkrankungen des Schultergelenkes herausgearbeitet werden. 37 Patienten wurden sowohl nativ als auch nach intraartikulaerer Gabe einer 2mmolaren Gd-DTPA-Loesung untersucht. Voraussetzungen fuer die KM-Gabe waren ein fehlender Gelenkerguss und/oder ein unklarer Befund des Labrum-Kapsel-Komplexes oder der Rotatorenmanschette in der Nativuntersuchung. Durch die MR-Arthrographie wurde bei 11/22 Patienten eine verbesserte Darstellung der Labrumpathologie erzielt; in 20/22 Faellen ergabe sich eine zuverlaessige Beurteilung der Gelenkkapsel. Bei 9/15 Patienten mit Erkrankungen der Rotatorenmanschette konnten Tendinitiden von partiellen und kleinen kompletten Rotatorenmanschettenrupturen sicher differenziert werden. Die MR-Arthrographie des Schultergelenkes fuehrt bei nicht eindeutigen Befunden in der Nativuntersuchung zu einer verbesserten Treffsicherheit der MR-Diagnostik. (orig.)

1) rheuma: komplementare therapien hoch im kurs; 2) ist der Ruckenschmerz magnetisch? 3) morbus alzheimer: unkonventionelle therapeutische Wundertute; 4) homocystein: Im westen nichts neues

Science.gov (United States)

Resch

2000-08-01

Wahrend in akademischen Kreisen noch ausgiebig diskutiert wird, wie Naturheilkunde, Komplementarmedizin und Alternativmedizin begrifflich fassbar gemacht, sprich definiert werden konnen, hat sich langst ein Parallelmarkt entwickelt, auf dem seriose und obskure Anbieter eine breite Palette von vermeintlich hilfreichen diagnostischen Massnahmen und Therapien feilbieten. Ohne kassenarztliche Vereinigung, ohne wissenschaftliche Fachgesellschaften, ohne amtlichen Segen. Der Markt boomt, wie das Beispiel rheumatische Erkrankungen zeigt. Das hat seine Grunde, von denen S. Hill in ihrem Kommentar einige nennt. Abstrahiert konnte man sagen, dass es offensichtlich einen grossen Bedarf in Bereichen gibt, fur die die konventionelle Medizin zu wenig zu bieten hat. Die daraus resultierende Tatsache, dass Patienten immer mehr bereit sind, zusatzlich und erganzend Leistungen einzukaufen, musste nicht weiter schrecken (und ware parteienubergreifend sogar ganz im Sinne unserer Gesundheitspolitiker), wenn man unterstellen konnte, Patienten hatten eine einigermassen verlassliche Moglichkeit, seriose Angebote von denen von Quacksalbern, Scharlatanen und miesen Geschaftemachern zu unterscheiden. Das haben Sie aber nicht. Die Beispiele in diesem Journal Club sollen aufzeigen, wie schwer es manchmal selbst dort ist, Stellung zu beziehen, wo bereits Versuche vorliegen, bestimmte Angebote zu hinterfragen. Das liegt nicht zuletzt an den ziemlich durchgangigen Defiziten, was die Forschungsqualitat in diesem Bereich anbelangt. Es scheint hochste Zeit, dass sich die akademische Medizin ihrer Verantwortung in diesem Bereich bewusst wird und sich seiner annimmt. Wer sonst sollte das tun? Copyright 2000 S. Karger GmbH, Freiburg

Pulmonary granulomatous diseases and pulmonary manifestations of systemic granulomatous disease. Including tuberculosis and nontuberculous mycobacteriosis; Pulmonale granulomatoese Erkrankungen und pulmonale Manifestationen systemischer Granulomatosen. Inklusive Tuberkulose und nichttuberkuloese Mykobakteriosen

Energy Technology Data Exchange (ETDEWEB)

Piel, S. [Universitaet Heidelberg, Zentrum fuer interstitielle und seltene Lungenerkrankungen, Pneumologie und Beatmungsmedizin, Thoraxklinik, Heidelberg (Germany); Kreuter, M.; Herth, F. [Universitaet Heidelberg, Zentrum fuer interstitielle und seltene Lungenerkrankungen, Pneumologie und Beatmungsmedizin, Thoraxklinik, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany); Kauczor, H.U. [Universitaetsklinikum Heidelberg, Abteilung fuer Diagnostische und Interventionelle Radiologie, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany); Heussel, C.P. [Universitaet Heidelberg, Abteilung fuer Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany)

2016-10-15

Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role. Further radiological modalities are usually not needed in the routine work-up of granulomatous diseases of the chest. In special cases magnetic resonance imaging (MRI) and positron emission tomography (PET)-CT scans play an important role, e. g. detecting cardiac sarcoidosis by cardiac MRI or choline C-11 PET-CT in diagnosing lung carcinoma in scar tissue after tuberculosis. The accuracy of thin-slice CT is very high for granulomatous diseases. In cases of chronic disease and fibrotic interstitial lung disease it is important to perform thin-slice CT in order to diagnose a specific disease pattern. Thin-slice CT is also highly sensitive in detecting disease complications and comorbidities, such as malignancies. Given these indications thin-slice CT is generally accepted in the routine daily practice. A thin-slice CT and an interdisciplinary discussion are recommended in many cases with a suspected diagnosis of pulmonary granulomatous disease due to clinical or radiographic findings. (orig.) [German] Granulome als Zeichen der spezifischen Entzuendung im Lungengewebe treten bei zahlreichen Erkrankungen mit pulmonaler Manifestation auf und stellen einen wichtigen Befund in der Bildgebung dar. Das radiologische Standardverfahren bei pulmonalen Granulomatosen ist meistens die Duennschichtcomputertomographie, in wenigen Faellen, wie z. B. bei Tuberkulose, Sarkoidose und Silikose, spielt die Roentgenthoraxuebersicht immer noch eine wichtige Rolle. Bei der Standardabklaerung der meisten Granulomatosen ist die Hinzunahme weiterer Verfahren nicht

Inflammatory diseases of the myelon; Entzuendliche Erkrankungen des Myelons

Energy Technology Data Exchange (ETDEWEB)

Spitzer, C. [Universitaetsklinikum Aachen (Germany). Klinik fuer Neurologie; Krings, T. [Universitaetsklinikum Aachen (Germany). Klinik fuer Neuroradiologie; Block, F. [Universitaetsklinikum Aachen (Germany). Klinik fuer Neurologie; Universitaetsklinikum Aachen (Germany). Klinik fuer Neuroradiologie

2001-11-01

Myelitis is defined as inflammatory disease of the spinal cord irrespective of the underlying aetiology or pathologic-anatomic alterations. It can be caused by direct infections, postinfectious or postvaccinal immunological processes or other (auto)immunological diseases such as multiple sclerosis or systemic vasculitis. The clinical presentation is diverse and varies from temporary sensory deficits to persistent tetraplegia with respiratory insufficiency. Diagnostic work-up must include a thorough anamnesis, clinical-neurological examination, neurophysiological studies, analysis of blood and cerebospinal fluid and neuroradiological investigations. Most important is the spinal MRI: small lesions as well as large lesions throughout the extent of the cord with accompanying edema can be identified reliably. Furthermore, neuroradiological examination can proof or rule out important differential diagnoses. In particular in acute transverse myelitis a quick diagnostic work-up with a spinal MRI is indispensible in order to start an appropriate therapy as soon as possible. (orig.) [German] Die Myelitis ist definiert als entzuendliche Erkrankung des Rueckenmarks, ungeachtet der in Frage kommenden Ausloeser oder pathologisch-anatomischen Veraenderungen. Ursachen sind direkte Infektionen, postinfektioese bzw.postvakzinale Immunprozesse und andere (auto)immunologische Erkrankungen wie die Multiple Sklerose oder systemische Vaskulitiden. Das klinische Bild ist vielgestaltig und variiert von leichten passageren Sensibilitaetsstoerungen bis hin zur persistierenden Tetraplegie mit Ateminsuffizienz. Die wesentlichen Saeulen in der Diagnostik sind sorgfaeltige Anamnese, klinische Untersuchung, neurophysiologische Zusatzuntersuchungen, Blut- und Liquoranalysen sowie neuroradiologische Verfahren. Untersuchungsmethode der Wahl ist hierbei die spinale Kernspintomographie: Kleine Herde bis hin zu ausgedehnten langstreckigen Myelonlaesionen mit Begleitoedemen koennen zuverlaessig

Inflammatory lesions of the spinal cord and the nerve roots in magnetic resonance imaging; Entzuendliche Erkrankungen des Rueckenmarks und der Nervenwurzeln in der MRT

Energy Technology Data Exchange (ETDEWEB)

Sartoretti-Schefer, S. [Inst. fuer Neuroradiologie, Universitaetsspital Zuerich (Switzerland); Wichmann, W. [Inst. fuer Neuroradiologie, Universitaetsspital Zuerich (Switzerland); Valavanis, A. [Inst. fuer Neuroradiologie, Universitaetsspital Zuerich (Switzerland)

1996-11-01

The MRI examinations of 52 patients with proven inflammatory lesions (39 patients) or tumorous/postactinic lesions of the spinal cord (6 patients) and vasuclar malformations of the spinal cord (7 patients) were retrospectively analyzed. All examinations were performed on a 1.5 T MR unit, using bi- or triplanar T1-w pre- and postcontrast as well as T2-w SE sequences. Clinical and radiological examinations allow a subdivision of inflammations of the spinal cord and the nerve roots into (mening-oradiculo) myelitis and meningoradiculo (myelitis). The MRI patterns of these two inflammatory subtypes vary: Meningoradiculitis presents with an enhancement of the nerve roots and the leptomeninges; myelitis itself is characterized by single or multiple, diffuse or multifocal, with or without nodular, patchy or diffusely enhancing intramedullary lessions, with or without thickening of the cord and leptomeningeal inflammation. The immunologically suppressed patient suffers from viral infections (especially herpes simplex, varicella-zoster virus, cytomegalovirus), bacterial infections (tuberculosis), but rarely viral infections, sarcoidosis and demyelinating diseases. Idiopathic myelitis is also common. Secondary ischemic and demyelinating processes result in a complex morphology of inflammatory lesions on MRI, and therefore the whole spectrum of demyelinating, ischemic and inflammatory lesions has to be included in the differential diagnosis. Even tumors may imitate inflammatory myelitis and radiculitis. Most commonly, meningoradiculitis can be separated from myelitis. A reliable diagnosis of a specific inflammatory lesion is difficult and is mostly achieved in patients with multiple sclerosis and in patients with HIV-associated cytomegalovirus infection. (orig.) [Deutsch] Entzuendliche Erkrankungen des Rueckenmarks und der Nervenwurzeln werden aus klinischer und radiologischer Sicht in eine (Meningo)-Myeloradikulitis und eine Meningoradikulo-(Myelitis) beim immunsupprimierten

Osteokalzinexpression and regulation in hematologic malignancies and in cultured cells

International Nuclear Information System (INIS)

Wihlidal, P.

2010-01-01

Main issue of this work was to gain further insight into the association of haematopoiesis and osteopoiesis. A crucial cue for that is the fact that haematopoietic stem cells of haematopoietic diseases, which are characterised by c-KIT (CD117) expression, express the osteoblast marker osteocalcin. Thus, attention was focussed on the expression and regulation of osteocalcin, on one hand in blood and bone marrow samples of haematological diseases and on the other hand in leukaemic and osteosarcoma cell lines, i.e., by 1. investigating the expression of osteocalcin (OCN) splicing variants in haematological malignancies. We analysed bone marrow obtained from two patients with chronic myeloid leukaemia (CML), seven patients with other myeloproliferative diseases (MPD) and four patients with acute myeloid leukaemia (AML). RT-PCR analyses were performed in order to assess and quantify spliced (OCNs) and unspliced (OCNu) mRNA, the associated transcription factors (AML1 and AML3) as well as c-KIT, which is a marker for activated stem cells. Our data indicate that OCNs mRNA and OCN protein are expressed in c-KIT positive neoplastic stem cells in haematological malignancies. 2. It has been suggested that the tyrosine kinase inhibitor imatinib mesylate (IM), which has proven anti-proliferative effect, influences osteogenesis and bone turnover in treated patients. Thus, we aimed to quantify OCN mRNA, its splicing variants, the associated Runt-domain transcription factors AML1 and AML3, c-KIT and several metabolic genes to gain evidence about the differentiation state in the HL-60 leukaemia cell line as well as MG63 and U2OS osteosarcoma cells and murine primary osteoblasts MC3T3-E1. Our data indicate that IM induces inhibition of proliferation and synthesis of total OCN-mRNA in all cell lines, but a relative increase of OCNs-mRNA was observed in the human cell lines. On the other hand, differentiation-associated genes appeared to be stimulated. This may also indicate an

Implementierung, Evaluation und vergleichende Untersuchungen des Powerplex 16 Systems zur quantitativen Chimärismusanalyse

OpenAIRE

Joachim, Stefanie

2010-01-01

Die allogene Stammzelltransplantation ist ein Verfahren zur Therapie verschiedener maligner und nicht-maligner hämatologischer Erkrankungen. Da es sich um eine sehr aufwendige Therapie handelt, sind Methoden, die den Behandlungsverlauf dokumentieren, wie minimale Resterkrankung und Chimärismusanalyse, essentiell. Eine nach Stammzelltransplantation vollständig vom Spender abgeleitete Hämatopoese ist Voraussetzung für das Engraftment und die Prophylaxe eines Rezidivs der zugrundeliegenden Er...

Stellenwert der Laparoskopie in Diagnostik und Therapie der Peritonealendometriose

Directory of Open Access Journals (Sweden)

Schweppe KW

2008-01-01

Full Text Available Die diagnostische Laparoskopie ist zurzeit das einzige Verfahren, eine Endometriose im kleinen Becken hinsichtlich Ausdehnung und Schweregrad zu beurteilen, mittels Biopsie zu sichern und andere Erkrankungen differenzialdiagnostisch auszuschließen. Therapeutisch ist sie bei peritonealer Endometriose der primäre Behandlungsschritt. Ihre Effektivität ist sowohl bei Schmerzpatientinnen als auch bei Kinderwunsch durch prospektiv randomisierte Studien nachgewiesen.

Quick scan IMS vendors

NARCIS (Netherlands)

Norp, A.H.J.; Pals, H.; Walraven, F.A.

2007-01-01

IMS is gaining momentum in the market. First operators are deploying IMS, while other operators are considering buying IMS. Operators have two approaches for introducing IMS and building an IMS eco-system: • Buying IMS from a large vendor or system integrator. Vendors like Alcatel-Lucent, Ericsson

IMS Application Developer's Handbook Creating and Deploying Innovative IMS Applications

CERN Document Server

Noldus, Rogier; Mulligan, Catherine; Fikouras, Ioannis; Ryde, Anders; Stille, Mats

2011-01-01

IMS Application Developer Handbook will give a hands-on view of exactly what needs to be done by IMS application developers to write an application and take it "live" on an operator's network. It will offer practical guidance on building innovative applications using the features and capabilities of the IMS network, show how the rapidly changing development environment is impacting on the business models employed in the industry and how existing network solutions can be moved towards IMS. The book will also elaborate on how IMS applies basic VoIP principles and techniques to realise a true mul

Early diagnosis of skeletal disorders in childhood and adolescence by MRI; Fruehdiagnose orthopaedischer Erkrankungen des Kindes- und Jugendalters mit der MRT

Energy Technology Data Exchange (ETDEWEB)

Meurer, A.; Schwitalle, M.; Engelhardt, O.; Heine, J. [Johannes Gutenberg-Univ. Mainz (Germany). Orthopaedische Klinik und Poliklinik; Kreitner, K.F. [Johannes Gutenberg-Univ. Mainz (Germany). Inst. fuer Klinische Strahlenkunde

1998-09-18

The early diagnosis of such disorders is of major importance because, in most cases, severe consequences can only be averted by early treatment. The value of magnetic resonance imaging (MRI) in many orthopaedic and traumatological conditions is generally accepted. The value of MRI in this particular field is illustrated by typical case reports on common clinical problems [Deutsch] Der Fruehdiagnose von Erkrankungen des Kindes- und Jugendalters kommt grosse Bedeutung zu, da oftmals nur durch eine daraus resultierende Fruehbehandlung schwerwiegende Folgen vermieden werden koennen. Die Kernspintomographie (Magnetresonanztomographie=MRT) ist in zahlreichen orthopaedischen-traumatologischen Fragestellungen bereits etabliert. An ausgewaehlten Fallbeispielen haeufiger klinischer Problemstellungen soll in der vorliegenden Arbeit der Stellenwert der MRT dargestellt werden. (orig.)

I'm a Map, I'm a Green Tree

Science.gov (United States)

Anderson, Daniel

2010-01-01

I'm talking about the ways we represent ourselves and our world. I've put some thoughts on the topic together here--a gathering that enacts new media creating and takes up conceptual layers like metaphors, models, and composing. The primary sources are videos from the Get a Mac campaign, aka I'm a Mac; I'm a PC ads. Posthuman concepts blending…

Long-term investigation of the risk of malignant diseases following intravenous radium-224 treatment for ankylosing spondylitis; Langzeituntersuchung zum Risiko maligner Erkrankungen nach intravenoeser Behandlung des Morbus Bechterew mit Radium-224

Energy Technology Data Exchange (ETDEWEB)

Schulte, Tobias L. [Klinik und Poliklinik fuer Allgemeine Orthopaedie und Tumororthopaedie, Universitaetsklinikum Muenster (Germany); Nekolla, Elke A. [Bundesamt fuer Strahlenschutz (BfS), Neuherberg (Germany); Wick, Roland R. [Inst. fuer Strahlenbiologie, Helmholtz-Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt, Neuherberg (Germany)

2009-09-15

Background and purpose: in German-speaking countries, the intravenous treatment of ankylosing spondylitis (AS) with radium-224 ({sup 224}Ra) was common between the late 1940s and 2005. In this long-term investigation, the risk of malignant diseases following intravenous {sup 224}Ra treatment for AS was assessed. Patients and methods: in a prospective long-term study, 1,471 patients with AS who were treated with {sup 224}Ra between 1948 and 1975 have been followed together with a control group of 1,324 AS patients treated neither with radioactive drugs nor with X-rays. Standardized questionnaires to evaluate the patients' health status were used. Observed numbers of malignant diseases were compared with those of the control group as well as with expected numbers for a normal population. Results: After 26 years of follow-up, causes of death have been certified for 1,006 patients of the exposure group (control group: 1,072 patients). Significantly increased rates of myeloid leukemia (12 cases observed vs. 2.9 expected; p < 0.001), kidney cancer (18 vs. 9.1; p < 0.01), thyroid cancer (4 vs. 1.2; p = 0.03) and borderline significantly increased rates of cancer of female genital organs (10 vs. 5.6; p = 0.06) were found in the exposure group in contrast to no significant increases of these diseases in the control group. Rates of pulmonary and gastrointestinal malignancies were not increased. Lymphatic leukemia (exposure group: 8 vs. 2.7; p < 0.01; control group: 7 vs. 3; p = 0.03) was significantly elevated due to a high rate of chronic lymphatic leukemia in both, the exposure as well as the control group. Conclusion: treatment of AS with {sup 224}Ra led to increased incidences of myeloid leukemia and malignancies of kidneys, thyroid and female genital organs. Although this kind of therapy is now abandoned, there is a need for close follow-up of patients who received it. (orig.)

Local treatment of solitary intrapulmonary, malignant nodules; Lokaltherapie solitaerer intrapulmonaler maligner Rundherde

Energy Technology Data Exchange (ETDEWEB)

Winkel, J. op den; Eichhorn, F. [Universitaetsklinikum Heidelberg, Abteilung Thoraxchirurgie, Thoraxklinik, Heidelberg (Germany); Rieken, S. [Universitaetsklinikum Heidelberg, Klinik fuer Strahlentherapie und Radioonkologie, Heidelberg (Germany); Dienemann, H. [Universitaetsklinikum Heidelberg, Abteilung Thoraxchirurgie, Thoraxklinik, Heidelberg (Germany); TLRC-H - Translational Lung Research Center Heidelberg, Heidelberg (Germany)

2017-02-15

Intrapulmonary nodules generally represent an incidental finding in the roentgenogram or computed tomography (CT) scan of the chest. They are defined as single, well-circumscribed, radiographic opaque lesions that measures up to 3 cm in diameter and are surrounded completely by aerated lung. The probability of malignancy directly correlates with increasing diameter. Lesions that have a diameter of 1 cm or larger require direct evaluation. Surgery is the first option for patients with a malignant lesion, given an acceptable perioperative risk; for high-risk patients either radiofrequency ablation (RFA) or stereotactic body radiation therapy (SBRT) should be offered. In these cases the malignant histology has to be established beforehand or verified by radiologic proven growth. Complete surgical resection is superior to RFA and SBRT with respect to local tumor control. (orig.) [German] Intrapulmonale Rundherde stellen in der Regel einen Zufallsbefund im Roentgenbild oder Computertomogramm des Thorax dar. Sie sind definiert als relativ gut abgegrenzte Laesionen von bis zu 3 cm Durchmesser, die allseits von Lungengewebe umgeben sind. Die Wahrscheinlichkeit fuer das Vorliegen eines malignen Tumors steigt mit ihrer Groesse. Rundherde ab 1 cm Durchmesser beduerfen der aktiven Abklaerung. Zur Behandlung solitaerer maligner Tumoren steht fuer Patienten ohne nennenswert erhoehtes Operations- und Narkoserisiko der chirurgische Eingriff an erster Stelle. Patienten, die aus funktionellen Gruenden fuer einen solchen nicht geeignet sind, koennen mit Radiofrequenzablation (RFA) oder Einzeitbestrahlung (SBRT) behandelt werden. In diesen Faellen muessen vor Therapiebeginn die Malignitaet nachgewiesen oder zumindest ueber einen begrenzten Zeitraum eine Groessenzunahme der Laesion dokumentiert worden sein. In Bezug auf die lokale Tumorfreiheit ist die Operation unter den Voraussetzungen einer R0-Resektion den anderen Verfahren ueberlegen. (orig.)

Organisationsprobleme im Ökomarketing

OpenAIRE

Dienel, Wolfram

2000-01-01

Organisationsprobleme im Ökomarketing - eine transaktionskostentheoretische Analyse im Absatzkanal konventioneller Lebensmittelhandel Die im Vergleich zum großen Nachfragepotential zögerliche Entwicklung des Ökomarkts in Deutschland ist auf Organisationsprobleme zurückzuführen. Die Organisationsprobleme behindern insbesondere die großskalige Ökomarkterschließung über die konventionellen Supermarktketten, erschweren aber auch die Effizienzsteigerung im kleiner strukturierten alternativen N...

Cerebral MR imaging of malignant melanoma; Zerebrale MR-Bildgebung beim malignen Melanom

Energy Technology Data Exchange (ETDEWEB)

Breckwoldt, M.; Bendszus, M. [Universitaetsklinikum Heidelberg, Abteilung Neuroradiologie, Neurologische Klinik, Heidelberg (Germany)

2015-01-16

even in asymptomatic patients. Stage IV requires quarterly MRI examinations. Melanotic and amelanotic metastases show different MRI characteristics. The differentiation between metastasis and microbleeding can be impossible and might require a follow-up scan. Susceptibility-weighted imaging increases the sensitivity of metastases detection but lacks specificity. It can help to differentiate between different metastatic entities. (orig.) [German] Das maligne Melanom (MM) ist nach dem Bronchial- und Mammakarzinom die dritthaeufigste Tumorentitaet, die in das ZNS metastasiert. Haeufig geschieht dies frueh im Krankheitsverlauf, was fuer die Prognose entscheidend ist. Zehn bis 40 % aller Patienten sterben an einer intrakraniellen Metastasierung, wobei die Inzidenz von Hirnmetastasen noch deutlich hoeher liegt (50-75 %). Praedilektionsstelle ist das subkortikale Marklager. Das Signalverhalten von Melanommetastasen kann sehr unterschiedlich sein und sich im Krankheitsverlauf, abhaengig von Melaningehalt, Akkumulation paramagnetischer Ionen und Einblutungen, aendern. Die neuen spezifischen Therapien (Immuntherapien und Kinaseinhibitoren) stellen auch fuer die Bildgebung eine Herausforderung dar, weil bislang nicht ausreichend geklaert ist, inwieweit diese das Signalverhalten von Metastasen in der MR-Bildgebung aendern. Zudem koennen unter den neuen Therapien immunassoziierte Pathologien (Hypophysitis bei ca. 5 % der Patienten unter Ipilimumab-Therapie) und granulomatoese Erkrankungen (Neurosarkoidose) auftreten. In der CT stellen sich Melanommetastasen haeufig nativ hyperdens dar. In der MRT sind T2w-Fluid-attenuated-inversion-recovery(FLAIR)-, native T1w- sowie T1w-Sequenzen nach Kontrastmittelgabe obligat. Mehrere Schnittebenen sollten akquiriert werden. Die suszeptibilitaetsgewichtete Bildgebung (SWI) ist eine neue sensitive Methode zur Detektion von Melanommetastasen bei jedoch eingeschraenkter Spezifitaet. Etwa 66 % der Melanommetastasen zeigen ausgepraegte intratumorale

Molecular imaging in neurological diseases; Molekulare Bildgebung bei neurologischen Erkrankungen

Energy Technology Data Exchange (ETDEWEB)

Reimold, M.; Fougere, C. la [Universitaetsklinikum Tuebingen, Abteilung Nuklearmedizin und Klinische Molekulare Bildgebung, Department Radiologie, Tuebingen (Germany)

2016-07-15

In neurodegeneration and in neuro-oncology, the standard imaging procedure, magnetic resonance imaging (MRI), shows limited sensitivity and specificity. Molecular imaging with specific positron-emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers allows various molecular targets and metabolic processes to be assessed and is thus a valuable adjunct to MRI. Two important examples are referred to here: amino acid transport for neuro-oncological issues, and the recently approved PET tracers for detecting amyloid depositions during the preclinical stage of Alzheimer's disease. This review discusses the clinical relevance and indications for the following nuclear medicine imaging procedures: amyloid PET, {sup 18}F-fluorodeoxyglucose (FDG)-PET, and dopamine transporter (DaT)-SPECT for the diagnosis of dementia and the differential diagnosis of Parkinson's disease, in addition to amino acid PET for the diagnosis of brain tumors and somatostatin receptor imaging in meningioma. (orig.) [German] Die Magnetresonanztomographie (MRT) weist als Standardverfahren bei neurodegenerativen und neuroonkologischen Fragestellungen eine eingeschraenkte Sensitivitaet und Spezifitaet auf. Die nuklearmedizinische molekulare Bildgebung mit spezifischen Positronenemissionstomographie(PET)- und single-photon-emission-computed-tomography(SPECT)-Tracern ermoeglicht die Darstellung verschiedener molekularer Targets bzw. Stoffwechselprozesse und stellt damit eine wichtige Ergaenzung zur MRT dar. Hier sei exemplarisch auf die Darstellung des Aminosaeuretransports im Rahmen neuroonkologischer Fragestellungen verwiesen, sowie auf die bereits im praeklinischen Stadium der Alzheimer-Demenz nachweisbaren Amyloidablagerungen mit hierfuer seit Kurzem zugelassenen PET-Tracern. Dieser Uebersichtsbeitrag bespricht die klinische Bedeutung bzw. die Indikationen der folgenden nuklearmedizinischen Untersuchungsverfahren: der Amyloid-PET, der {sup 18}F

Phylogenetische und funktionelle Analysen zur Kapsel O-Acetyltransferase NeuO von Escherichia coli K1

OpenAIRE

Mordhorst, Ines Louise

2010-01-01

Escherichia coli ist ein Kommensale des menschlichen und tierischen Gastrointestinaltraktes. Einige E. coli-Stämme sind in der Lage, extraintestinale Erkrankungen beim Menschen wie Harnwegsinfekte, Neugeborenen-Meningitis und Sepsis, sowie beim Tier aviäre Coliseptikämien, hervorzurufen. Ein wichtiger Virulenzfaktor des Bakteriums ist dabei die aus α-2,8-verknüpften Sialinsäuremonomeren aufgebaute K1-Kapsel, die phasenvariabel mit einer hohen Frequenz O-acetyliert werden kann. Im Jahr 20...

Neural correlates of working memory deficits in schizophrenic patients. Ways to establish neurocognitive endophenotypes of psychiatric disorders; Neuronale Korrelate gestoerter Arbeitsgedaechtnisfunktionen bei schizophrenen Patienten. Ansaetze zur Etablierung neurokognitiver Endophaenotypen psychiatrischer Erkrankungen

Energy Technology Data Exchange (ETDEWEB)

Gruber, O. [Universitaet des Saarlandes, Klinik fuer Psychiatrie und Psychotherapie, Homburg (Saar) (Germany); Max-Planck-Institut fuer Kognitions- und Neurowissenschaften, Leipzig (Germany); Gruber, E.; Falkai, P. [Universitaet des Saarlandes, Klinik fuer Psychiatrie und Psychotherapie, Homburg (Saar) (Germany)

2005-02-01

This article briefly reviews some methodological limitations of functional neuroimaging studies in psychiatric patients. We argue that the investigation of the neural substrates of cognitive deficits in psychiatric disorders requires a combination of functional neuroimaging studies in healthy subjects with corresponding behavioral experiments in patients. In order to exemplify this methodological approach we review recent findings regarding the functional neuroanatomy of distinct components of human working memory and provide evidence for selective dysfunctions of cortical networks that underlie specific working memory deficits in schizophrenia. This identification of subgroups of schizophrenic patients according to neurocognitive parameters may facilitate the establishment of behavioral and neurophysiological endophenotypes and the development of a neurobiological classification of psychiatric disorders. (orig.) [German] Dieser Beitrag befasst sich mit einigen methodischen Problemen funktionell-bildgebender Studien mit psychiatrischen Patienten, aufgrund derer die Untersuchung der neuronalen Korrelate kognitiver Defizite bei psychiatrischen Erkrankungen einer Kombination funktionell-bildgebender Studien bei gesunden Normalprobanden mit Verhaltensuntersuchungen bei Patienten bedarf. Dieser methodische Ansatz wird am Beispiel von Arbeitsgedaechtnisfunktionen erlaeutert, wobei zunaechst neuere Erkenntnisse zur funktionellen Neuroanatomie verschiedener Komponenten des menschlichen Arbeitsgedaechtnisses referiert werden. Anschliessend werden bei schizophrenen Patienten erhobene Befunde vorgestellt, die auf spezifische Stoerungen der funktionellen Integritaet neuronaler Netzwerke mit Arbeitsgedaechtnisfunktionen hinweisen. Die damit verbundene Identifikation von Subgruppen schizophrener Patienten koennte zur Etablierung verhaltensneurophysiologisch definierter Endophaenotypen psychiatrischer Stoerungsbilder fuehren und die Entwicklung einer neurowissenschaftlich

Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies

International Nuclear Information System (INIS)

Mundt, Arno J.; Lujan, Anthony E.; Rotmensch, Jacob; Waggoner, Steven E.; Yamada, S. Diane; Fleming, Gini; Roeske, John C.

2002-01-01

Purpose: To describe our initial clinical experience with intensity-modulated whole pelvic radiotherapy (IM-WPRT) in women with gynecologic malignancies. Methods and Materials: Between February 2000 and August 2001, 40 gynecology patients underwent IM-WPRT. After fabrication of customized immobilization, all patients underwent contrast-enhanced CT, and a clinical target volume was contoured consisting of the upper vagina, parametria, uterus (if present), and presacral and pelvic lymph node regions. The clinical target volume was expanded by 1 cm to create a planning target volume (PTV). Using commercially available software, 7- or 9-field, 6-MV, coplanar IM-WPRT plans were generated for all patients. The worst acute gastrointestinal and genitourinary toxicity during treatment was scored on a 4-point scale: 0, none; 1, mild, no medications required; 2, moderate, medications required; and 3, severe, treatment breaks or cessation, hospitalization. As a comparison, acute toxicities in 35 previously treated conventional WPRT patients were analyzed. No significant differences were noted in the clinicopathologic and treatment factors between the two groups. Results: IM-WPRT plans provided excellent PTV coverage, with considerable sparing of the surrounding normal tissues. On average, 98.1% of the PTV received the prescription dose. The average percentage of the PTV receiving 110% and 115% of the prescription dose was 9.8% and 0.2%, respectively. IM-WPRT was well tolerated, with no patient developing Grade 3 toxicity. Grade 2 acute gastrointestinal toxicity was less common in the IM-WPRT group (60 vs. 91%, p=0.002) than in the conventional WPRT group. Moreover, the percentage of IM-WPRT and WPRT patients requiring no or only infrequent antidiarrheal medications was 75% and 34%, respectively (p=0.001). Although less Grade 2 genitourinary toxicity was seen in the IM-WPRT group (10% vs. 20%), this difference was not statistically significant (p=0.22). Conclusion: IM-WPRT is a

Cross-sectional environmental study comparing two highly polluted areas in Germany (Bitterfeld and Hettstedt) with a control region; Umweltmedizinische Untersuchungen im Raum Bitterfeld, im Raum Hettstedt und einem Vergleichsgebiet 1992-2000. Bd. 1: Textband. Bd. 2: Publikationen. Bd. 3: Untersuchungsdokumente und Frageboegen. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Heinrich, J.; Frye, C.; Hoelscher, B.; Meyer, I.; Pitz, M.; Cyrys, J.; Schneller, H.; Wjst, M.; Wichmann, H.E.

2001-10-01

-Zerbst zu ermitteln. Darueber hinaus wurden die zeitlichen Veraenderungen der Gesundheitsparameter begleitend zu den laufenden Sanierungsmassnahmen ueber den Zeitraum von 6 Jahren erfasst. Das Studiendesign bestand aus 3 wiederholten regionalen Querschnittsuntersuchungen in den Jahren 1992/93, 1995/96 und 1998/99. Insgesamt lagen Informationen von 7611 Frageboegen zur Auswertung vor (Beteiligungsrate: 89%, 75% bzw. 75%). Fuer die Belastungsregion Hettstedt waren deutlich hoehere Risiken fuer nicht allergische respiratorische Erkrankungen und Symptome im Vergleich zu Kindern des Kontrollgebietes Anhalt-Zerbst nachweisbar. Waehrend des Untersuchungszeitraumes 1992-1999 zeigte sich eine deutlich statistisch signifikante Abnahme der Praevalenz dieser gesundheitlichen Einschraenkungen, Kinder ohne Exposition mit Innenraumschadstoffen im haeuslichen Bereich profitieren von der Verbesserung der Aussenluftbelastung am meisten. Fuer die Verbesserung der Atemwegsgesundheit sprachen auch bessere Lungenfunktionswerte (FVC, FEV{sub 1}) im Laufe des Beobachtungszeitraumes 1992-1999. Kinder aus den beiden Belastungsregionen hatten haeufiger Allergien (Arztdiagnose, Symptome, allergenspezifischer Antikoerper-Nachweis). Die Haeufigkeit des Asthmas, der bronchialen Hyperreaktivitaet und der Neurodermitis nahm zu; die Praevalenz des Heuschnupfens und der allergischen Sensibilisierung nicht. Die korporale Belastung mit Blei und Cadmium war bei Kindern in den belasteten Regionen erhoeht, nahm aber im Verlauf des Beobachtungszeitraumes ab. Allerdings folgten gestiegenen Bleigehalten im Sedimentationsstaub in Hettstedt im Jahre 1997 leicht gestiegene Blutbleikonzentrationen. (orig.)

Cross-sectional environmental study comparing two highly polluted areas in Germany (Bitterfeld and Hettstedt) with a control region; Umweltmedizinische Untersuchungen im Raum Bitterfeld, im Raum Hettstedt und einem Vergleichsgebiet 1992-2000. Bd. 1: Textband. Bd. 2: Publikationen. Bd. 3: Untersuchungsdokumente und Frageboegen. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Heinrich, J; Frye, C; Hoelscher, B; Meyer, I; Pitz, M; Cyrys, J; Schneller, H; Wjst, M; Wichmann, H E

2001-10-01

ermitteln. Darueber hinaus wurden die zeitlichen Veraenderungen der Gesundheitsparameter begleitend zu den laufenden Sanierungsmassnahmen ueber den Zeitraum von 6 Jahren erfasst. Das Studiendesign bestand aus 3 wiederholten regionalen Querschnittsuntersuchungen in den Jahren 1992/93, 1995/96 und 1998/99. Insgesamt lagen Informationen von 7611 Frageboegen zur Auswertung vor (Beteiligungsrate: 89%, 75% bzw. 75%). Fuer die Belastungsregion Hettstedt waren deutlich hoehere Risiken fuer nicht allergische respiratorische Erkrankungen und Symptome im Vergleich zu Kindern des Kontrollgebietes Anhalt-Zerbst nachweisbar. Waehrend des Untersuchungszeitraumes 1992-1999 zeigte sich eine deutlich statistisch signifikante Abnahme der Praevalenz dieser gesundheitlichen Einschraenkungen, Kinder ohne Exposition mit Innenraumschadstoffen im haeuslichen Bereich profitieren von der Verbesserung der Aussenluftbelastung am meisten. Fuer die Verbesserung der Atemwegsgesundheit sprachen auch bessere Lungenfunktionswerte (FVC, FEV{sub 1}) im Laufe des Beobachtungszeitraumes 1992-1999. Kinder aus den beiden Belastungsregionen hatten haeufiger Allergien (Arztdiagnose, Symptome, allergenspezifischer Antikoerper-Nachweis). Die Haeufigkeit des Asthmas, der bronchialen Hyperreaktivitaet und der Neurodermitis nahm zu; die Praevalenz des Heuschnupfens und der allergischen Sensibilisierung nicht. Die korporale Belastung mit Blei und Cadmium war bei Kindern in den belasteten Regionen erhoeht, nahm aber im Verlauf des Beobachtungszeitraumes ab. Allerdings folgten gestiegenen Bleigehalten im Sedimentationsstaub in Hettstedt im Jahre 1997 leicht gestiegene Blutbleikonzentrationen. (orig.)

The child with an acute limp; Das hinkende Kind. Radiologische Differenzialdiagnostik der akuten Gangstoerung des Kinder- und Jugendalters

Energy Technology Data Exchange (ETDEWEB)

Stadler, A.; Puig, S.; Eisenhuber, E.; Rand, T. [Universitaetsklinik fuer Radiodiagnostik, Wien (Austria)

2002-03-01

Limping is a common and often challenging problem in children and adolescents. A limp is defined as asymetric deviation from a normal gait pattern. A systematic approach is necessary to determine the cause of the limp, so the radiologist should combine a thorough history, clinical information and pertinent radiologic testing. The possible differential diagnosis is extensive and includes many pathologies of the lower extremity and spine like trauma, infection, neoplasia, furthermore inflammatory, developmental and congenital disorders. In cases with knee or tight pain, an underlying hip condition should be considered. The childs age can narrow the possible differential diagnoses, because certain entities are age-related. Despite this wide bandwidth of entities, potential catastrophic causes like septic arthritis and malignant disease should be excluded first. Plain radiographs are often diagnostic. The choice of further imaging modalities like ultrasonography, magnetic resonance imaging, computed tomography and bone scan should be guided by the history and clinical findings. (orig.) [German] Die Abklaerung der hinkenden Gangstoerung bei Kindern und Jugendlichen ist ein haeufiges und oft komplexes diagnostisches Problem. Hinken ist definiert als eine asymmetrische Abweichung vom normalen Gangmuster. Um die Ursache des Hinkens suffizient abklaeren zu koennen, ist ein systematisches Vorgehen mit sorgfaeltiger Anamneseerhebung, orientierender klinischer Untersuchung, sowie eine adaequate Wahl der radiologischen Modalitaet durch den Radiologen notwendig. Das weite Spektrum der moeglichen Differenzialdiagnosen umfasst viele Pathologien der unteren Extremitaet wie Trauma, infektioese, neoplastische und entzuendliche Erkrankungen sowie erworbene und angeborene Stoerungen. In Faellen, in denen das Kind Knie- oder Oberschenkelbeschwerden angibt, muss zusaetzlich an eine Erkrankung der Huefte gedacht werden. Da viele Erkrankungen eine bestimmte Altersgruppe bevorzugen, kann

Value of CT-guided biopsy in malignant lymphoma; Wertigkeit der CT-gesteuerten Biopsie maligner Lymphome

Energy Technology Data Exchange (ETDEWEB)

Libicher, M.; Noeldge, G.; Radeleff, B.; Gholipur, F.; Richter, G.M. [Abteilung Radiodiagnostik, Universitaetsklinikum Heidelberg (Germany)

2002-12-01

beschreibt den Stellenwert CT-gesteuerter Biopsien maligner Lymphome im Vergleich zu den operativen Verfahren. Ausserdem werden anhand der Literatur die Aspekte diskutiert, die einer erfolgreichen perkutanen Biopsie zugrunde liegen. (orig.)

Beginn und Dosisanpassung einer intensivierten konventionellen Insulintherapie (ICT beim Erwachsenen

Directory of Open Access Journals (Sweden)

Lohr R

2012-01-01

Full Text Available Eine intensivierte Insulintherapie (ICT ist die Behandlung der Wahl bei Diabetes mellitus Typ 1 und auch bei vielen Menschen mit insulinpflichtigem Typ-2-Diabetes. Bei Therapiebeginn müssen individuell Insuline ausgewählt und die richtige Dosierung festgelegt werden. Im weiteren Verlauf ist dann die Anpassung der Insulintherapie an besondere Alltagssituationen wie Sport oder akute Erkrankungen vorrangig. Eine gute Patientenschulung und eine gute Zusammenarbeit zwischen Betroffenem und Behandlerteam sind entscheidend, um diese komplizierte Therapie erfolgreich umzusetzen.

Herz-Kreislauf-Krankheiten

OpenAIRE

Jüni, Peter; Siegrist, Johannes

2012-01-01

Rund ein Drittel der weltweiten Todesfälle sind auf Herz-Kreislauf-Krankheiten zurückzuführen. In den industrialisierten Ländern sind sie die häufigste Todesursache. Den größten Anteil hat dabei die koronare Herzkrankheit, gefolgt vom Schlaganfall und der Herzinsuffizienz. In westlichen Industrienationen dürfte jede zweite Person im Lauf ihres Lebens an Herz-Kreislauf-Krankheiten erkranken. Da das Risiko mit zunehmendem Alter zunimmt, wird die Anzahl von Herz-Kreislauf- Erkrankungen aufgru...

Inductive Monitoring System (IMS)

Data.gov (United States)

National Aeronautics and Space Administration — IMS: Inductive Monitoring System The Inductive Monitoring System (IMS) is a tool that uses a data mining technique called clustering to extract models of normal...

Integrating IMS LD and IMS QTIv2 using CopperCore Service Integration

NARCIS (Netherlands)

Vogten, Hubert

2006-01-01

Vogten, H. (2006). Integrating IMS LD and IMS QTIv2 using CopperCore Service Integration. Presentation at International Workshop in Learning Networks for Lifelong Competence Development. March, 30-31, 2006. Sofia, Bulgaria: TENCompetence Conference. Retrieved June 30th, 2006, from

Nuclear medicine for treatment of thyroid diseases. Diagnostic evaluation and imaging of the intrathyroid metabolism; Einsatz der Nuklearmedizin bei Schilddruesenerkrankungen. Diagnostik und bildliche Darstellung des intrathyreoidalen Stoffwechsels

Energy Technology Data Exchange (ETDEWEB)

Maul, F.D. [Klinik fuer Nuklearmedizin, Staedtisches Klinikum, Karlsruhe (Germany)

1996-05-01

The diagnostic interest of nuclear medicine is focussed on the imaging and quantification of intrathyroidal iodine metabolism. Most frequently the various forms of autonomy will be investigated by functional scintigraphy. Cold nodules and the differential diagnosis of Graves disease are further indications. In the case of a sufficient iodine uptake hyperthyroidism can be treated by 1311. Severe hyperthyroidism requires a medical pretreatment before radioiodine therapy. A rigid age limit for radioiodine therapy is not necessary. Pregnancy and the suspicion of malignancy are contraindications of a radioiodine therapy. The after-treatment depends on the nature of the treated hyperthyroidism and the posttreatment result. If a focal autonomy could be eliminated a sufficient amount of iodine should be supplied. To prevent the development of hypothyroidism clinical and thyroid hormon controls, and if necessary a substitution with thyroxin is necessary. (orig.) [Deutsch] Bei der Diagnostik und Therapie von Schilddruesenerkrankungen steht die Diagnostik und bildliche Darstellung der intrathyreoidalen Stoffwechselstoerung im Zentrum. Am haeufigsten wird die Schilddruesenfunktionsszintigraphie bei den verschiedenen Formen der autonomen Schilddruesenerkrankungen eingesetzt. Sie dient aber auch der Diagnostik kalter Knoten und der Differenzierung von Autoimmunthyreopathien. Ausreichende Iodspeicherung vorausgesetzt, koennen hyperthyreote Erkrankungen der Schilddruese mit {sup 131}I behandelt werden. (orig./MG)

Erkrankungen des Traumaspektrums bei ruandischen Waisen des Genozids : Epidemiologie und Behandlung

OpenAIRE

Schaal, Susanne

2006-01-01

Im Jahre 1994 kamen in Ruanda innerhalb von 100 Tagen fast eine Million Menschen auf brutalste Weise ums Leben. Vorliegende Studie untersuchte die Traumakonfrontation und mentalen Gesundheitseffekte dieses staatlich organisierten Genozids bei ruandischen Waisen (n = 118) 11 Jahre nach dem Völkermord. Die Stichprobe setzte sich aus Vollwaisen zusammen, die entweder in kindergeführten Haushalten oder in Waisenheimen der Hauptstadt Kigali lebten. Risikofaktoren wurden analysiert und die Wirksamk...

Resilience in IMS

DEFF Research Database (Denmark)

Kamyod, Chayapol; Nielsen, Rasmus Hjorth; Prasad, Neeli R.

2012-01-01

) and supporting always on services. Therefore, not only Quality of Service (QoS) but also resilience is required. In this paper, we attempt to evaluate and analyze end-to-end reliability of the IMS system using a model proposed as a combination of Reliability Block Diagram (RBD) and Markov Reward Models (MRMs......Reliability evaluation of systems has been widely researched for improving system resilience especially in designing processes of a complex system. The convergence of different access networks is possible via IP Multimedia Subsystem (IMS) for development toward Next Generation Networks (NGNs......). The resilience of the IMS architecture is studied by applying 1:1 redundancy at different communication scenarios between end users within and across communication domains. The model analysis provides useful reliability characteristics of the system and can be further applied for system design processes....

Delegation und Kooperation im Gesundheitswesen

OpenAIRE

Rosenau, Henning

2010-01-01

Delegation und Kooperation im Gesundheitswesen. - In: Tıpta işbirliği ve hukuksal sorunlar = Delegation und Kooperation im Gesundheitswesen / ed.: Hakan Hakeri ... - Samsun : Adalet, 2010. - S. 7-18

Innovationsmanagement im Marketing: Anleitung zur Innovations-Sensibilisierung und deren Umsetzung im Rahmen der Neuen Lernkultur

OpenAIRE

Mangisch, Christian; Blatter, Martin

2009-01-01

Der Kurs “Innovationsmanagement im Marketing“ vermittelt den Teilnehmenden Wissen zum Innovationsmanagement, zum innovativen Team und zu innovativen Marketing Trends. Diese Kurse sind online auf dem folgenden Link www.ritzycampus.ch zu finden. Die Teilnehmer müssen für den Online-Kurs keine speziellen Kenntnisse oder Voraussetzungen mitbringen. Diese Online-Kurse im Fach Marketing sind an ein breites Publikum gerichtet. Sie ermöglichen den Studierenden im Eigenstudium die Grundlagen der Theme...

Δim-lacunary statistical convergence of order α

Science.gov (United States)

Altınok, Hıfsı; Et, Mikail; Işık, Mahmut

2018-01-01

The purpose of this work is to introduce the concepts of Δim-lacunary statistical convergence of order α and lacunary strongly (Δim,p )-convergence of order α. We establish some connections between lacunary strongly (Δim,p )-convergence of order α and Δim-lacunary statistical convergence of order α. It is shown that if a sequence is lacunary strongly (Δim,p )-summable of order α then it is Δim-lacunary statistically convergent of order α.

[Kriegsland im Osten Eroberung, Kolonisierung und Militärherrschaft im Ersten Weltkrieg] / Markus Pöhlmann

Index Scriptorium Estoniae

Pöhlmann, Markus

2003-01-01

Rets.: Vejas Gabriel Liulevicius. Kriegsland im Osten Eroberung, Kolonisierung und Militärherrschaft im Ersten Weltkrieg. Aus dem Amerikanischen von Jürgen Bauer, Edith Nerke und Fee Engemann. Hamburg : 2002

CopperCore Service Integration, Integrating IMS Learning Design and IMS Question and Test Interoperability

NARCIS (Netherlands)

Vogten, Hubert; Martens, Harrie; Nadolski, Rob; Tattersall, Colin; Van Rosmalen, Peter; Koper, Rob

2006-01-01

Vogten, H., Martens, H., Nadolski, R., Tattersall, C., Rosmalen, van, P., Koper, R., (2006). CopperCore Service Integration, Integrating IMS Learning Design and IMS Question and Test Interoperability. Proceedings of the 6th IEEE International Conference on Advanced Learning Technologies (pp.

Volatility study of [C1C1im][NTf2] and [C2C3im][NTf2] ionic liquids

International Nuclear Information System (INIS)

Rocha, Marisa A.A.; Ribeiro, Filipe M.S.; Schröder, Bernd; Coutinho, João A.P.; Santos, Luís M.N.B.F.

2014-01-01

Highlights: • Vapor pressures of [C 1 C 1 im][NTf 2 ] and [C 2 C 3 im][NTf 2 ] ionic liquids are reported. • [C 1 C 1 im][NTf 2 ] presents higher enthalpy and entropy of vaporization than expected. • The high volatility of [C 2 C 3 im][NTf 2 ] is a result from its asymmetric character. -- Abstract: Vapor pressures of 1,3-dimethylimidazolium bis(trifluoromethylsulfonyl)imide, ([C 1 C 1 im][NTf 2 ]) and 1-ethyl-3-propylimidazolium bis(trifluoromethylsulfonyl)imide, ([C 2 C 3 im][NTf 2 ]) ionic liquids were measured as a function of temperature using a Knudsen effusion apparatus combined with a quartz crystal microbalance. Enthalpies and entropies of vaporization were derived from the fitting of vapor pressure and temperature results to the Clarke and Glew equation. [C 1 C 1 im][NTf 2 ] presents a higher enthalpy and entropy of vaporization than the neighboring members of the series. The enthalpy of vaporization of [C 2 C 3 im][NTf 2 ] lies in between the asymmetric and symmetric ionic liquid series, reflecting a decrease in the electrostatic interactions due to a decrease of the charge accessibility between the ionic pairs when the methyl group is replaced by an ethyl group. The obtained higher volatility of [C 2 C 3 im][NTf 2 ] arises from its asymmetric character, leading to an higher entropic contribution that compensates the enthalpic penalty. The border conditions ([C 1 C 1 im][NTf 2 ], [C 2 C 1 im][NTf 2 ] and [C 2 C 2 im][NTf 2 ]), topology ([C 2 C 3 im][NTf 2 ]) and symmetry/asymmetry of the ILs effect were evaluated and rationalized based on a comparative analysis of the thermodynamic properties, enthalpies and entropies of vaporization

Application of Hadamard transform in IMS

International Nuclear Information System (INIS)

Sha Miaomiao; Liu Weihao; Chen Yong; Jiang Dazhen

2008-01-01

Hadamard transform can improve the SNR by increasing the ion duty cycle in IMS. In this paper, the ion spectral signals were processed by Hadamard transform based on the IMS detector hardware platform. The results showed that Hadamard transform can greatly improve the SNR of the IMS detector in contrast with traditional method. (authors)

E2eUberIM

DEFF Research Database (Denmark)

Wac, Katarzyna; Cummings, Mark; Dey, Jayanta

2016-01-01

, high-quality services, we propose an innovative end-to-end service management framework called e2eUberIM. This framework contains a scalable, flexible, and volatile information model (UberIM) and a real-time, "organic" communication and storage process (e2eUber). It leverages the proprietary interfaces...... of different vendors, enabling the resulting enhanced operations system environment to automatically and in real-time optimize operational overhead while maximizing the user experience, and quickly field new innovative, composed "any-services" (XaaS). We document the e2eUberIM requirements and its design...

Imágenes e identidades

OpenAIRE

Guerrini, Sebastión

2013-01-01

Las identidades se estructuran en un proceso de identificación continua con imágenes. Esto afecta no solo a las identidades de las personas, sino también a las de las instituciones, organizaciones y empresas. En este sentido, el rol de ser del Diseño en Comunicación Visual es intentar afectar a las identidades de los espectadores de sus imágenes. Por esta razón, primero es importante definir qué son las imágenes. Facultad de Bellas Artes

λ (Δim) -statistical convergence of order α

Science.gov (United States)

Colak, Rifat; Et, Mikail; Altin, Yavuz

2017-09-01

In this study, using the generalized difference operator Δim and a sequence λ = (λn) which is a non-decreasing sequence of positive numbers tending to ∞ such that λn+1 ≤ λn+1, λ1 = 1, we introduce the concepts of λ (Δim) -statistical convergence of order α (α ∈ (0, 1]) and strong λ (Δim) -Cesàro summablility of order α (α > 0). We establish some connections between λ (Δim) -statistical convergence of order α and strong λ (Δim) -Cesàro summablility of order α. It is shown that if a sequence is strongly λ (Δim) -Cesàro summable of order α, then it is λ (Δim) -statistically convergent of order β in case 0 < α ≤ β ≤ 1.

Advanced Interval Management (IM) Concepts of Operations

Science.gov (United States)

Barmore, Bryan E.; Ahmad, Nash'at N.; Underwood, Matthew C.

2014-01-01

This document provides a high-level description of several advanced IM operations that NASA is considering for future research and development. It covers two versions of IM-CSPO and IM with Wake Mitigation. These are preliminary descriptions to support an initial benefits analysis

Integrating IMS Learning Design and IMS Question and Test Interoperability using CopperCore Service Integration

NARCIS (Netherlands)

Vogten, Hubert; Martens, Harrie; Nadolski, Rob; Tattersall, Colin; Van Rosmalen, Peter; Koper, Rob

2006-01-01

Please, cite this publication as: Vogten, H., Martens, H., Nadolski, R., Tattersall, C., van Rosmalen, P., & Koper, R. (2006). Integrating IMS Learning Design and IMS Question and Test Interoperability using CopperCore Service Integration. Proceedings of International Workshop in Learning Networks

Clinical appearance and treatment of malignant pleural mesothelioma; Klinik und Therapie des malignen Pleuramesothelioms

Energy Technology Data Exchange (ETDEWEB)

Schiebe, M. [Tuebingen Univ. (Germany). Abt. fuer Strahlentherapie; Hoffmann, W. [Tuebingen Univ. (Germany). Abt. fuer Strahlentherapie; Kortmann, R.D. [Tuebingen Univ. (Germany). Abt. fuer Strahlentherapie; Bamberg, M. [Tuebingen Univ. (Germany). Abt. fuer Strahlentherapie

1994-11-01

We report about 7 of our own cases, treated with surgery and radiotherapy (4) or with a combination of surgery, radiotherapy and chemotherapy (3) and discuss the clinical aspects, diagnosis and the different ways of treatment of malignant pleural mesothelioma and its influence on survival. (orig.) [Deutsch] Wir berichten ueber sieben Patienten, die operiert und bestrahlt (vier) oder durch eine Kombination von operativen Massnahmen, Strahlen- und Chemotherapie behandelt wurden (drei). Klinische und diagnostische Aspekte sowie verschiedene Therapiemodalitaeten in der Behandlung des malignen Pleuramesothelioms werden im Ueberblick dargestellt. (orig.)

Synthesis and DNA binding properties of 1-(3-aminopropyl)-imidazole-containing triamide f-Im*PyIm: a novel diamino polyamide designed to target 5'-ACGCGT-3'.

Science.gov (United States)

Satam, Vijay; Babu, Balaji; Porte, Alexander; Savagian, Mia; Lee, Megan; Smeltzer, Thomas; Liu, Yang; Ramos, Joseph; Wilson, W David; Lin, Shicai; Kiakos, Kostantinos; Hartley, John A; Lee, Moses

2012-09-15

A novel diamino/dicationic polyamide f-Im(*)PyIm (5) that contains an orthogonally positioned aminopropyl chain on an imidazole (Im(*)) moiety was designed to target 5'-ACGCGT-3'. The DNA binding properties of the diamino polyamide 5, determined by CD, ΔT(M), DNase I footprinting, SPR, and ITC studies, were compared with those of its monoamino/monocationic counterpart f-ImPyIm (1) and its diamino/dicationic isomer f-ImPy(*)Im (2), which has the aminopropyl group attached to the central pyrrole unit (Py(*)). The results gave evidence for the minor groove binding and selectivity of polyamide 5 for the cognate sequence 5'-ACGCGT-3', and with strong affinity (K(eq)=2.3×10(7) M(-1)). However, the binding affinities varied according to the order: f-ImPy(*)Im (2)>f-ImPyIm (1)≥f-Im(*)PyIm (5) confirming that the second amino group can improve affinity, but its position within the polyamide can affect affinity. Copyright © 2012 Elsevier Ltd. All rights reserved.

Ion Mobility Spectrometer / Mass Spectrometer (IMS-MS)

Energy Technology Data Exchange (ETDEWEB)

Hunka, Deborah E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Austin, Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2005-10-01

The use of Ion Mobility Spectrometry (IMS)in the Detection of Contraband Sandia researchers use ion mobility spectrometers for trace chemical detection and analysis in a variety of projects and applications. Products developed in recent years based on IMS-technology include explosives detection personnel portals, the Material Area Access (MAA) checkpoint of the future, an explosives detection vehicle portal, hand-held detection systems such as the Hound and Hound II (all 6400), micro-IMS sensors (1700), ordnance detection (2500), and Fourier Transform IMS technology (8700). The emphasis to date has been on explosives detection, but the detection of chemical agents has also been pursued (8100 and 6400).

Cryotherapy of malignant tumors: MR imaging in comparison with pathological changes in mice; Kryotherapie maligner Tumoren: Untersuchungen mittels MRT im Tierexperiment und Vergleich mit morphologischen Veraenderungen

Energy Technology Data Exchange (ETDEWEB)

Romaneehsen, B.; Anders, M.; Roehrl, B.; Hast, H.J.; Schiffer, I.; Neugebauer, B.; Teichmann, E.; Schreiber, W.G.; Thelen, M. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Hengstler, J.G. [Mainz Univ. (Germany). Inst. fuer Toxikologie

2001-07-01

Aim of our study was to investigate the efficacy of 7 F cryoprobes for percutaneous use morpho- and histologically, to examine the role of apoptosis after cryotherapy, and to compare contrast-enhanced MRI with histopathological findings at different time intervals in a tumor-mouse model. Methods: Percutaneous cryotherapy was performed in 15 immunocompromised nude mice with subcutaneously implanted tumors using the non-small-cell lung cancer cell line Lu 1. In group a) 7 mice were sacrificed after definite time intervals and histological examinations were done for evaluation of necrosis and apoptosis (HE; TUNEL assay); 2 mice are in long-term follow-up. In group b) in 6 mice tumor destruction and perfusion before and after freezing were investigated with native and contrast-enhanced MR imaging (T{sub 1}- and T{sub 2}-weighted spin-echo) and compared with histopathological findings. Histological control were done in 2 untreated mice. Results: We observed fast tumor-reduction within two weeks (ca. 50%). On long-term follow-up (> 6 months) no recurrence has been noticed so far. Tumors were well vascularized prior to treatment and did not-show contrast enhancement an any time after cryotherapy. A narrow contrast-enhanced zone was seen on the tumor border subcutaneously as a sign of peripheral hyperemia and central vascular stasis after cryotherapy. On histology there was evidence of both apoptosis and necrosis. (orig.) [German] Evaluierung der Durchfuehrbarkeit und Effizienz einer perkutanen Kryotherapie mittels 7-F-Kryosonde in Nacktmaeusen. Erheben des histopathologischen Befundes der Kryolaesion nach definierten Zeitintervallen und Ueberpruefung einer moeglichen Rolle der Apoptose nach Kryotherapie. Darstellung morphologischer Veraenderungen des Tumors und des angrenzenden Gewebes im Anschluss an die Kryotherapie mittels kontrastmittelunterstuetzter MRT. Methodik: Zweiminuetige Kryotherapie subkutan implantierter Tumoren eines nicht-kleinzelligen Bronchialkarzinoms

A New IMS Based Inter-working Solution

Science.gov (United States)

Zhu, Zhongwen; Brunner, Richard

With the evolution of third generation network, more and more multimedia services are developed and deployed. Any new service to be deployed in IMS network is required to inter-work with existing Internet communities or legacy terminal users in order to appreciate the end users, who are the main drivers for the service to succeed. The challenge for Inter-working between IMS (IP Multimedia Subsystem) and non-IMS network is “how to handle recipient’s address”. This is because each network has its own routable address schema. For instance, the address for Google Talk user is xmpp:xyz@google.com, which is un-routable in IMS network. Hereafter a new Inter-working (IW) solution between IMS and non-IMS network is proposed for multimedia services that include Instant Messaging, Chat, and File transfer, etc. It is an end-to-end solution built on IMS infrastructure. The Public Service Identity (PSI) defined in 3GPP standard (3rd Generation Partnership Project) is used to allow terminal clients to allocate this IW service. When sending the SIP (Session Initial Protocol) request out for multimedia services, the terminal includes the recipient’s address in the payload instead of the “Request-URI” header. In the network, the proposed solution provides the mapping rules between different networks in MM-IW (Multimedia IW). The detailed technical description and the corresponding use cases are present. The comparison with other alternatives is made. The benefits of the proposed solution are highlighted.

Medicinal therapy of malignant lymphomas; Medikamentoese Therapie maligner Lymphome

Energy Technology Data Exchange (ETDEWEB)

Aul, C.; Schroeder, M.; Giagounidis, A. [Medizinische Klinik II, St.-Johannes-Hospital Duisburg (Germany)

2002-12-01

von Chemo- und Strahlentherapie durchgefuehrt.Mit dem neuen Chemotherapieprotokoll BEACOPP konnte die Prognose von Patienten in fortgeschrittenen Krankheitsstadien im Vergleich zum international akzeptierten Standard COPP/ABVD verbessert werden. Die Heilungsquoten liegen stadienabhaengig zwischen 95 und 50%. Bei den indolenten Non-Hodgkin-Lymphomen,die sich bei Diagnosestellung meist in disseminierten Krankheitsstadien befinden, wird die Chemotherapie in palliativer Zielsetzung, d. h. zur Kontrolle von Krankheitskomplikationen und zur Verbesserung der Lebensqualitaet der Patienten eingesetzt. Bei aggressiven und sehr aggressiven Non-Hodgkin-Lymphomen besitzt die Chemotherapie kuratives Potenzial und muss stadienunabhaengig sofort nach Diagnosestellung begonnen werden. Das in den 90er Jahren etablierte Standardprotokoll CHOP (Cyclophosphamid, Doxorubicin,Vincristin und Prednison) konnte in den letzten Jahren durch Verkuerzung der Therapieintervalle (CHOP-14 vs.CHOP-21), Erweiterung durch Etoposid (CHOEP) und Kombination mit dem monoklonalen Antikoerper Rituximab (R-CHOP) in seiner Wirksamkeit verbessert werden. Der Stellenwert einer Hochdosistherapie mit Stammzelltransplantation konnte bislang nur bei chemotherapiesensiblen rezidivierten Hodgkin-Lymphomen und hochmalignen Non-Hodgkin-Lymphomen gesichert werden.Die Behandlungsstrategien maligner Lymphome werden in den naechsten Jahren durch Einfuehrung neuer Zytostatika, Weiterverbreitung monoklonaler Antikoerper, Erprobung neuartiger Transplantationsverfahren und Entwicklung von Substanzen mit molekular definiertem Wirkungsmechanismus weiter verbessert werden. Rascher Wissenszuwachs ist nur durch Rekrutierung und Behandlung neu diagnostizierter Patienten in den grossen deutschen oder europaeischen Multicenterstudien zu erwarten. (orig.)

Argumentellipse in der "weichen" Nachricht im Deutschen und im Slowenischen

Directory of Open Access Journals (Sweden)

Uršula Krevs

1998-12-01

Full Text Available Argumentellipsen werden in der sprachlichen Kommunikation ohne weiteres akzeptiert, obwohl sie allenfalls in gewissem Sinne wegen ihrer Elliptizität abweichend wirken. Im folgenden interessiert uns, wie die Argumentellipse als syntaktische Entität in den Text eingebettet wird und welche Funktionen sie ausübt. Unsere Aufmerksamkeit gilt bier der Textsorte "weiche" Nachricht, die als Abweichung des Grundmusters gilt. Um im Sprachenpaar Deutsch-Slowenisch die in dieser Textsorte realisierten Argumentellipsen vergleichen zu können, wurde die Homogenität in der Thematik angestrebt und die Texte aus dem gleichen Kommunikationsbereich gewählt. So wurden die Korpora zwei Zeitschriften, die sich mit der gleichen Sportart beschäftigen, entnommen: der deutschen Zeitschrift "Rotpunkt" und der slowenischen Zeitschrift  "Grif '.

Wie kann der adäquate ärztliche Umgang mit Emotionen im Medizinstudium vermittelt werden? Ein Erfahrungsbericht aus dem Strang "Ärztliche Interaktion" im Modellstudiengang Medizin der Ruhr-Universität Bochum [How to teach the adequate handling of emotions during medical studies? A field report on "Medical Interaction" as part of a problem-based curriculum at the Ruhr University in Bochum, Germany

Directory of Open Access Journals (Sweden)

Rusche, Herbert

2009-08-01

Full Text Available [english] Handling strong emotions like sorrow, anger, shame, and fear in patients with somatic disease in an adequate way is a key issue for the future physician. Up to now, this aspect of the doctor?patient relationship has played a minor role in medical studies. To address this shortcoming, the handling of emotions is the focus of the third semester in the “Medical Interaction” course of the Modellstudiengang Medizin, the problem-based track of the medical faculty in Bochum, Germany. The course presented is given by the Department of General Medicine.The main objective is the recognition and correct interpretation of patients’ emotional expressions. The course is composed of six modules (one introductory and one for each leading affect. The main teaching methods are realistic role plays in a small group setting with video feedback, whereby one main requirement is that each student plays the role of both the patient and the doctor. Each session is introduced and analyzed by a general practitioner experienced in psychosomatic medicine. Evaluation of the course has shown a high acceptance among students. This motivates us to conduct a public discussion on the possibilities of applying this concept in other medical studies as well. [german] Der adäquate Umgang mit Emotionen wie Trauer, Wut, Scham und Angst bei Patienten mit körperlichen Erkrankungen spielt für den werdenden Arzt eine Schlüsselrolle. Dieser Aspekt der Arzt-Patient-Beziehung wird allerdings im Medizinstudium bislang wenig berücksichtigt. Aus diesem Grunde wird der Umgang mit Emotionen im dritten Semester des Stranges „ärztliche Interaktion“ im Modellstudiengang Medizin der Ruhr-Universität Bochum thematisiert. Der vorgestellte Kurs wird von der Abteilung für Allgemeinmedizin durchgeführt.Zielsetzung ist die Verbesserung der emotionalen und kommunikativen Kompetenz des Studierenden. Um dies zu erreichen soll dem eigenen emotionalen Erleben in der Arzt

IMS Learning Design Frequently Asked Questions

NARCIS (Netherlands)

Tattersall, Colin; Manderveld, Jocelyn; Hummel, Hans; Sloep, Peter; Koper, Rob; De Vries, Fred

2004-01-01

This list of frequently asked questions was composed on the basis of questions asked of the Educational Technology Expertise Centrum. The questions addessed are: Where can I find the IMS Learning Design Specification? What is meant by the phrase “Learning Design”? What is the IMS LD Specification

Resilience of the IMS system

DEFF Research Database (Denmark)

Kamyod, Chayapol; Nielsen, Rasmus Hjorth; Prasad, Neeli R.

2014-01-01

The paper focuses on end-to-end resilience analysis of the IMS based network through the principal resilience parameters by using OPNET. The resilience behaviours of communication across multiple IMS domains are investigated at different communication scenarios and compared with previous state......-of-the-art. Moreover, the resilience effects when adding a redundancy of the S-CSCF unit are examined. The results disclose interesting resilience behaviours for long distance communications....

Individualisierte Produkte im Fokus der intergrierten Produktentwicklung

OpenAIRE

Baumberger, C.;Gahr, A.

2017-01-01

Individualisierte Produkte stellen neue Herausforderungen an die Produktentwicklung – vornehmlich im Bereich der Produktstrukturplanung, der kundenindividuellen Produktadaption und dem Zielkostenmanagement. Diese Themen werden am Lehrstuhl für Produktentwicklung im Rahmen des Sonderforschungsbereiches 582 behandelt.

Managing P2P services via the IMS

NARCIS (Netherlands)

Liotta, A.; Lin, L.

2007-01-01

The key aim of our work was to illustrate the benefits and means to deploy P2P services via the IMS. Having demonstrated the technical viability of P2P-IMS we have also found a way to add a new management dimension to existing P2P systems. P2P-IMS comes with a natural "data management" mechanism,

Geschlechterstereotype im Einsatz

Directory of Open Access Journals (Sweden)

Erika Kegyes

2007-11-01

Full Text Available Die umfangreiche Monographie gehört zum Forschungsbereich der kritischen angewandten Linguistik (Critical Applied Linguistics und liegt sowohl theoretisch als auch praktisch im Schnittpunkt der gender- und werbesprachlichen Untersuchungen.

DEGRO guidelines for the radiotherapy of non-malignant disorders. Part II: Painful degenerative skeletal disorders

Energy Technology Data Exchange (ETDEWEB)

Ott, Oliver J. [University Hospitals Erlangen, Dept. of Radiation Oncology, Erlangen (Germany); Niewald, Marcus [Saarland University Medical School, Dept. of Radiotherapy and Radiation Oncology, Homburg/Saar (Germany); Weitmann, Hajo-Dirk [Fulda Hospital, Dept. of Radiooncology and Radiotherapy, Fulda (Germany); Jacob, Ingrid [Municipal Hospital Traunstein, Dept. of Radiotherapy, Traunstein (Germany); Adamietz, Irenaeus A. [Marien Hospital Herne/Ruhr University Bochum, Dept. of Radiotherapy and Radiation Oncology, Herne (Germany); Schaefer, Ulrich [Lippe Hospital, Dept. of Radiotherapy, Lemgo (Germany); Keilholz, Ludwig [Bayreuth Hospital, Dept. of Radiotherapy, Bayreuth (Germany); Heyd, Reinhard [Center for Radiosurgery, Frankfurt a. M. (Germany); Muecke, Ralph [Marien Hospital Herne/Ruhr University Bochum, Dept. of Radiotherapy and Radiation Oncology, Herne (Germany); Lippe Hospital, Dept. of Radiotherapy, Lemgo (Germany); Collaboration: German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD)

2014-09-20

The purpose of this article is to summarize the updated DEGRO consensus S2e guideline recommendations for the treatment of benign painful degenerative skeletal disorders with low-dose radiotherapy. This overview reports on the role of low-dose radiotherapy in the treatment of enthesiopathies (shoulder syndrome, trochanteric bursitis, plantar fasciitis, and elbow syndrome) and painful arthrosis (knee, hip, hand, and finger joints). The most relevant aspects of the DEGRO S2e Consensus Guideline Radiation Therapy of Benign Diseases 2014 regarding diagnostics, treatment decision, dose prescription as well as performance of radiotherapy and results are summarized. For all indications mentioned above, retrospective and some prospective analyses have shown remarkable effects in terms of pain relief. Nevertheless, the Level of Evidence (LoE) and the Grade of Recommendation (GR) vary: LoE 1b-4 and GR A-C. Low-dose radiotherapy for painful degenerative skeletal disorders is effective in the majority of the patients and therefore it may be a reasonable therapeutic alternative when simple and non-invasive methods have been used without persistent success. For all discussed entities, single fraction doses of 0.5-1.0 Gy and total doses of 3.0-6.0 Gy/series applied with 2-3 fractions per week are recommended. (orig.) [German] Zusammenfassung der Empfehlungen der DEGRO-S2e-Leitlinie zur Niedrigdosis-Radiotherapie von gutartigen schmerzhaften degenerativen Skeletterkrankungen. Die vorliegende Zusammenfassung berichtet ueber die Bedeutung der Niedrigdosis-Radiotherapie in der Behandlung von Enthesiopathien (Schultersyndrom, Ellenbogensyndrom, Bursitis trochanterica, Fasciitis plantaris) und schmerzhaften Arthrosen (Knie-, Hueft, Hand- und Fingergelenksarthrosen). Die wichtigsten Aspekte der aktuellen DEGRO-S2e-Konsensus-Leitlinie Strahlentherapie gutartiger Erkrankungen bezueglich Diagnostik, Therapieentscheidungen, Dosisempfehlungen und Durchfuehrung einer Radiotherapie werden

Diagnostik und Therapie der kutanen Androgenisierung im klimakterischen Übergang sowie in der Peri- und Postmenopause: Hirsutismus und Alopezie

Directory of Open Access Journals (Sweden)

Geisthövel F

2012-01-01

Full Text Available Die weibliche Androgenisierung umfasst ein weites Spektrum an heterogenen Dysfunktionen und Erkrankungen. Um die Therapieprinzipien des Hirsutismus sowie der Alopecia androgenetica während des klimakterischen Übergangs („menopausal transition“ [MT] und der Peri-/Postmenopause zu erfassen, ist es sinnvoll, sich auf eine Gruppe von androgenisierten Patientinnen zu beschränken, bei der die Haut pathogenetisch im Fokus liegt. Solch eine klar definierte Patientengruppe, die „funktionell kutane Androgenisierung“ (FCA, kann meist schon über die Diagnostikebene 1 (Screening-Ebene unseres Klassifikations-Algorithmus diagnostiziert werden. Der Ferriman-Gallwey-Index bzw. eine modifizierte Sinclair-Scale dienen zur Gradeinteilung von Hirsutismus bzw. Alopezie. Die ausgeprägte endokrine Dynamik während der MT ist hormondiagnostisch zu beachten. Wachsepilation und Lasertherapie sind vielfältig eingesetzte topischmechanische bzw. -physikalische Therapieverfahren. Eine topische Behandlung des Hirsutismus kann auch mit Eflornithin-Creme durchgeführt werden, die den Effekt einer Lasertherapie unterstützt. Minoxidil-Lösung gilt als Mittel der ersten Wahl bei der topischen Therapie der Alopecia androgenetica. Steroidale Präparate, welche aus der kontrazeptiven Kombination von Ethinylestradiol und antiandrogenen Gestagenen (AA bestehen, sind therapeutische Prinzipien bei androgenisierten Patientinnen in der MT, sie sind hingegen in der Postmenopause kontraindiziert. Die orale Einnahme von Spironolacton und/oder Finasterid, beides nicht-steroidale Antiandrogene, ist während der MT unter sicherer Kontrazeption und jene von Spironolacton für die Alopezie in der Postmenopause gut geeignet. Die Einnahme von Kombinationsprapäraten, welche die nicht-kontrazeptiven natürlichen Östrogene und AA enthalten, sind für die Behandlung der FCA bei Patientinnen indiziert, die zusätzlich unter klimakterischen und peri-/postmenopausalen Störungen leiden

Muriithi, IM

African Journals Online (AJOL)

Muriithi, IM. Vol 8, No 2 (2014) - Articles Correlation of magnetic resonance imaging findings with arthroscopy in the evaluation of rotator cuff pathology. Abstract PDF · Vol 8, No 2 (2014) - Articles Patterns of knee, hip and hand osteoarthritis in Kenyatta National Hospital Abstract PDF. ISSN: 1994-1072. AJOL African ...

Ion mobility spectrometer / mass spectrometer (IMS-MS).

Energy Technology Data Exchange (ETDEWEB)

Hunka Deborah Elaine; Austin, Daniel E.

2005-07-01

The use of Ion Mobility Spectrometry (IMS) in the Detection of Contraband Sandia researchers use ion mobility spectrometers for trace chemical detection and analysis in a variety of projects and applications. Products developed in recent years based on IMS-technology include explosives detection personnel portals, the Material Area Access (MAA) checkpoint of the future, an explosives detection vehicle portal, hand-held detection systems such as the Hound and Hound II (all 6400), micro-IMS sensors (1700), ordnance detection (2500), and Fourier Transform IMS technology (8700). The emphasis to date has been on explosives detection, but the detection of chemical agents has also been pursued (8100 and 6400). Combining Ion Mobility Spectrometry (IMS) with Mass Spectrometry (MS) is described. The IMS-MS combination overcomes several limitations present in simple IMS systems. Ion mobility alone is insufficient to identify an unknown chemical agent. Collision cross section, upon which mobility is based, is not sufficiently unique or predictable a priori to be able to make a confident peak assignment unless the compounds present are already identified. Molecular mass, on the other hand, is much more readily interpreted and related to compounds. For a given compound, the molecular mass can be determined using a pocket calculator (or in one's head) while a reasonable value of the cross-section might require hours of computation time. Thus a mass spectrum provides chemical specificity and identity not accessible in the mobility spectrum alone. In addition, several advanced mass spectrometric methods, such as tandem MS, have been extensively developed for the purpose of molecular identification. With an appropriate mass spectrometer connected to an ion mobility spectrometer, these advanced identification methods become available, providing greater characterization capability.

Bremssysteme im Personenkraftwagen

Science.gov (United States)

Reif, Konrad

Für die ersten drei Punkte ist die Betriebsbremsanlage ("Fußbremse“) zuständig. Der Fahrer aktiviert sie durch Betätigen des Bremspedals. Die Feststellbremsanlage ("Handbremse“) hält das Fahrzeug im Stillstand.

Support interoperability and reusability of emerging forms of assessment: Some issues on integrating IMS LD with IMS QTI

NARCIS (Netherlands)

Miao, Yongwu; Boon, Jo; Van der Klink, Marcel; Sloep, Peter; Koper, Rob

2009-01-01

Miao, Y., Boon, J., Van der Klink, M., Sloep, P. B., & Koper, R. (2011). Support interoperability and reusability of emerging forms of assessment: Some issues on integrating IMS LD with IMS QTI. In F. Lazarinis, S. Green, & E. Pearson (Eds.), E-Learning Standards and Interoperability: Frameworks

Politische Inhalte im Internet: Angebot und Nachfrage politischer Inhalte im World Wide Web am Beispiel von Volksabstimmungen in der Schweiz

OpenAIRE

Rademacher, Patrick Horst Josef

2010-01-01

Welche Bedeutung kommt dem Internet in der Politikvermittlung zu? Dieser Frage geht Patrick Rademacher nach, indem er untersucht, welche Anbieter politische Inhalte im Internet zur Verfügung stellen, wie sie dabei vorgehen und wie die Struktur der Inhalte beschaffen ist. Darüber hinaus analysiert er, inwiefern die online angebotenen Inhalte auf eine Nachfrage durch die Bürger treffen. Im Untersuchungskontext von Volksabstimmungen in der Schweiz hat der Autor hierfür im Jahr 2008 umfangreiche ...

Gruppenbezogene Menschenfeindlichkeit im Sport in Brandenburg

OpenAIRE

Delto, Hannes; Tzschoppe, Petra

2016-01-01

Mit der Querschnittsstudie "Wir und die Anderen – Gruppenbezogene Menschenfeindlichkeit im organisierten Sport in Brandenburg" wurde das Syndrom Gruppenbezogener Menschenfeindlichkeit im organisierten Sport untersucht. Das Konzept der Gruppenbezogenen Menschenfeindlichkeit – ausgehend von einer Ideologie der Ungleichwertigkeit – wurde von Prof. Wilhelm Heitmeyer (Universität Bielefeld) entwickelt. Die Ergebnisse ermöglichen explizite Aussagen über Ausmaß und Ursachen Gruppenbezogener Menschen...

Verletzungen und Fehlbeanspruchungen im leistungsorientierten Rudersport

OpenAIRE

Bussian, Marc Robert

2004-01-01

Die Stellung der Breitensportart Rudern als gesundheitsfördernde Sportform ist in der Literatur gleichlautend positiv beschrieben. Im leistungsorientierten Rudersport müssen neben den Verletzungen und Fehlbeanspruchungen der eigentlichen Sportart die unabdingbaren Nebentrainingsformen berücksichtigt werden. In den neunziger Jahren vollzog sich ein trainingsmethodischer Wandel, die Einführung eines erschwinglichen Rudersimulators und eine technische Weiterentwicklung im Boots- und Ruderbau. Ei...

Pengaruh Intensitas Mengakses Twitter Duta Im3 terhadap Kepuasan Pengalaman Adopsi dan Kepuasan Pengalaman Adopsi terhadap Keputusan Penggunaan Program Im3

OpenAIRE

Ayu Kinasih, Diyan Hafdinovianti; Pradekso, Tandiyo; Setiabudi, Djoko

2014-01-01

Nama : Diyan H Ayu KinasihNIM : D2C009029Judul : Pengaruh Intensitas Mengakses Twitter Duta IM3 terhadapKepuasan Pengalaman Adopsi dan Kepuasan PengalamanAdopsi terhadap Keputusan Penggunaan Program IM3ABSTRAKTwitter sebagai salah satu promotion tools yang digunakan oleh PTIndosat Tbk, diharapkan dapat memperkenalkan program-program serta eventyang dilakukan oleh Indosat. Melalui duta IM3 sebagai brand ambassador, Indosatmencoba meraih pasar anak muda dengan melakukan kegiatan promosi.Tipe pe...

The Application of Internal Marketing (IM in a Service Organization

Directory of Open Access Journals (Sweden)

R. Sharma

2013-07-01

Findings and Strategic Implications. To complement earlier theoretical proposition on IM, the findings indicate that there are several empirical aspects such as “costs, people and concept” which hinder successful implementation of IM. This study proposes several strategic HR recommendations to reduce the “implementation gap” in IM such as to conduct continuous staff training on IM knowledge on regular time intervals, to reduce excessive work load and pressure and engaging staff members in continuous personal development sessions. In addition, the findings reveal that IM training should be given priority to solve “people-oriented” issues.

Wozu und wie kooperative Arbeitsformen im studienbegleitenden Deutschunterricht?

Directory of Open Access Journals (Sweden)

Karmelka Barić

2016-04-01

Full Text Available Ausgehend von einer Reflexion über die im Beruf und im Leben notwendigen Kompetenzen in der Kommunikation sowie von der Überzeugung, dass es notwendig ist, diese Kompetenzen schon im Studium durch geeignete Arbeitsverfahren und Themen zu entwickeln, werden Kooperation und Autonomie fördernde Arbeitsformen für den studienbegleitenden Deutsch- und Fremdsprachenunterricht (SDU/SFU vorgestellt. Diese Arbeitsformen sind auf andere Sprachen übertragbar und aus dem Lehrwerk Mit Deutsch studieren arbeiten leben A2/B1 (Lévy-Hillerich, Serena, Barić & Cickovska 2010 und der dazu gehörenden Lernplattform entnommen. Das Lehrwerk selbst ist eine Umsetzung der SDU-Rahmencurricula, die im Laufe von über zwanzig Jahren in zehn Ländern im Rahmen eines 1994 am Goethe-Institut Warschau begonnenen Hochschulprojekts und der daraus entstandenen Forschungstätigkeit entstanden sind. Grundlage des Projekts ist ein ganzheitlicher soziopädagogischer Ansatz, der LernerInnen als Menschen betrachtet, die im Präsenz- oder im virtuellen Unterricht in der Sprache und durch die Sprache fach- und sprachübergreifende Kooperationsfähigkeiten entwickeln, die sich später im Leben in der Gesellschaft auswirken. Nach der Vorstellung des Projekts und seiner wissenschaftlichen Hintergründe im ersten Teil des Beitrags werden im zweiten Teil die sich aus dem Ansatz ergebenden Arbeitsformen untersucht: Dabei werden die sich dazu eignenden Themen, die Lernhilfen für StudentInnen, die den LehrerInnen zufallenden Rollen sowie die Ansprüche an Lehrbücher/Unterrichtsmaterialien und Online-/Blended-Learning-Lernszenarien besprochen. Der abschließende Überblick im dritten Teil über die Schwierigkeiten, die beim kooperativen Lernen im SDU/SFU auftreten können, ist gleichzeitig eine offenbleibende Frage danach, wie LehrerInnen aus- und fortgebildet werden sollten, um sich den Anforderungen einer sich dauernd verändernden Lernlandschaft stellen zu können.   The paper

Die Rule of Law im Völker- und im Europarecht – aktuelle Probleme

Directory of Open Access Journals (Sweden)

Helmut Tichy

2015-04-01

Full Text Available Diese am 5. März 2015 in Graz gehaltene Antrittsvorlesung eines Praxisprofessors, der im Hauptberuf Leiter des Völkerrechtsbüros im österreichischen Außenministerium ist, beschäftigt sich mit dem Begriff der Herrschaft des Rechts in den internationalen Beziehungen (Rule of Law und mit den Möglichkeiten Österreichs, zur Stärkung der Rule of Law und zur Lösung aktueller Probleme beizutragen. Dabei werden insbesondere die Mitwirkung an Kodifikationsbemühungen und an der Verbesserung der Einhaltung des humanitären Völkerrechts, die Umsetzung der Menschenrechte (auch in Österreich und Fragen der internationalen Gerichtsbarkeit angesprochen.

Gruppenbezogene Menschenfeindlichkeit im Sport in Sachsen

OpenAIRE

Delto, Hannes; Tzschoppe, Petra

2015-01-01

Mit der Querschnittsstudie „Wir und die Anderen – Gruppenbezogene Menschenfeindlichkeit im organisierten Sport in Sachsen“ wurde erstmals das Syndrom Gruppenbezogener Menschenfeindlichkeit im organisierten Sport untersucht. Das Konzept der Gruppenbezogenen Menschenfeindlichkeit – ausgehend von einer Ideologie der Ungleichwertigkeit – wurde von Prof. Wilhelm Heitmeyer (Universität Bielefeld) entwickelt. Die Ergebnisse ermöglichen explizite Aussagen über Ausmaß und Ursachen Gruppenbezogener Men...

Usability test of the ImPRO, computer-based procedure system

International Nuclear Information System (INIS)

Jung, Y.; Lee, J.

2006-01-01

ImPRO is a computer based procedure in both flowchart and success logic tree. It is evaluated on the basis of computer based procedure guidelines. It satisfies most requirements such as presentations and functionalities. Besides, SGTR has been performed with ImPRO to evaluate reading comprehension and situation awareness. ImPRO is a software engine which can interpret procedure script language, so that ImPRO is reliable by nature and verified with formal method. One bug, however, had hidden one year after release, but it was fixed. Finally backup paper procedures can be prepared on the same format as VDU in case of ImPRO failure. (authors)

Midlatitude magnetometer chains during the IMS

International Nuclear Information System (INIS)

Mcpherron, R.L.

1982-01-01

The International Magnetospheric Study (IMS) is an international program to study global problems of magnetospheric dynamics. A key element of the U.S. participation in this program was the establishment of a ground magnetometer network. This network included a number of arrays at high and low latitudes. This report describes three chains established at midlatitudes, including the IMS Midlatitude Chain, the AFGL Magnetometer Network, and the Bell Lab Conjugate Array. Descriptions of the type of equipment, station locations, types of data display, and availability of data for each chain are presented in this report. A major problem of the data analysis phase of the IMS will be reducing selected subsets of these data to a common format. Currently, there are no plans to do this in a systematic manner

Implantate im Mittelohrbereich - Teil 2 (Ergänzungen 2007)

Science.gov (United States)

Stieve, M.; Lenarz, Thomas

In Deutschland leben ca. 12 Millionen Menschen, die an einer ein- oder beidseitigen Schwerhörigkeit leiden. Diese kann angeboren oder im Laufe des Lebens erworben sein. Klinisch und therapeutisch wichtig ist die Unterscheidung hinsichtlich des Schädigungsortes im Bereich des Mittelohres, d. h. eine Schalleitungsschwerhörigkeit, oder im Bereich des Innenohres, d. h. eine Schallempfindungsschwerhörigkeit, wobei hier der Schädigungsort auch am Hörnerven oder in den zentralen Hörabschnitten liegen kann. Therapeutisch lassen sich sowohl Schwerhörigkeiten im Bereich des Mittelohres als auch im Innenohr und sogar im Hirnstammbereich (Hirnstammimplantat) behandeln. 1,9 Millionen Schwerhörige haben eine Erkrankung im Mittelohrbereich, d. h. der Schall kann nur ungenügend auf das Innenohr übertragen werden. Die Ursache besteht meist in einer chronischen Mittelohrentzündung, die zu einer Zerstörung des Trommelfells und der Gehörknöchelchenkette geführt haben. Therapeutisch und damit als Prinzip der operativen Hörverbesserung steht primär der Verschluß des Trommelfells oder eine Rekonstruktion der Gehörknöchelchen. Mittelohroperationen werden mikrochirurgisch unter dem Operationsmikroskop durchgeführt, wobei zunächst durch eine sanierende Operation der Entzündungsprozeß entfernt wird und nach einer Ausheilungszeit die Gehörknöchelchenkette durch künstliche Prothesen rekonstruiert werden kann.

Minería de imágenes

OpenAIRE

Fernández, Jacqueline; Miranda, Natalia Carolina; Guerrero, Roberto A.; Piccoli, María Fabiana

2006-01-01

Durante los últimos años, la proliferación de los medios digitales ha creado la necesidad del desarrollo de herramientas para la eficiente representación, acceso y recuperación de información visual. La minería de imágenes se ha convertido en una importante rama de investigación a causa del potencial que posee en descubrir patrones característicos a partir de un importante conjunto de imágenes. No obstante, la minería de imágenes es más que una simple extensión de la minería de datos al domin...

Die Pluralbildung im Deutschen - ein Versuch im Rahmen der Optimalitätstheorie

Directory of Open Access Journals (Sweden)

Wegener, Heide

1999-01-01

Full Text Available Die Pluralbildung im Deutschen ist nicht chaotisch, aber komplex. Unabhängig davon, ob man für die Pluralbildung Regeln, Schemata oder die Wortstruktur als Erklärungsmodell benutzt, bleibt die Tatsache einer beachtlichen Zahl miteinander konkurrierender Formen zu erklären. Dies gilt schon deshalb, weil die Variation unter den Pluralformen wohl mit dazu beiträgt, dass trotz der Arbeiten von Mugdan 1977 und Köpcke 1987, 1993, der klaren Darstellung des Pluralsystems in vielen Grammatiken, z.B. Eisenberg 1986, 1989, 1998 noch immer bisweilen die Meinung besteht, die Pluralbildung im Deutschen sei arbiträr.Es soll gezeigt werden, dass das Pluralsystem des Deutschen nach Beschränkungen aufgebaut ist, die morphologischer und silbenphonologischer Natur sind und sich im Rahmen der Optimalitätstheorie (OT beschreiben lassen. Die OT nimmt an, dass Wortformen universalen Beschränkungen (Constraints unterliegen, und dass diese prinzipiell verletzbar sind. Ich werde zunächst die für die Pluralbildung relevanten Beschränkungen definieren, dann an heimischen Pluralformen und -varianten ihr Zusammenwirken zeigen und schließlich den Assimilationsprozess von Fremdwörtern mit Hilfe dieser Beschränkungen und der Beschränkungshierarchien zu erklären versuchen. Daran werden schließlich Überlegungen zu Verarbeitung und Lernbarkeit der Pluralformen geknüpft.

Medienerziehung im Vorschulbereich - Zum Projekt Mediengarten der Wiener Medienpädagogik

Directory of Open Access Journals (Sweden)

Gudrun Kern

2010-09-01

Full Text Available Im Zuge des Projekts Mediengarten der Wiener Medienpädagogik wurde in Kooperation mit angehenden KindergartenpädagogInnen eine Medienerziehung im Sinne einer Auseinandersetzung über Medien im Vorschulbereich anhand konkreter Angebote in Kindergärten konzipiert. Im folgenden Artikel werden die Schwerpunktsetzungen dieses Konzepts vorgestellt und durch praktische Beispiele verdeutlicht.

Cyberbullying und Empathie : affektive, kognitive und medienbasierte Empathie im Kontext von Cyberbullying im Kindes- und Jugendalter

OpenAIRE

Pfetsch, Jan; Müller, Christin R.; Ittel, Angela

2014-01-01

"Bei medial vermittelter Kommunikation sinkt sowohl die Hemmschwelle für aggressive Verhaltensweisen wie Cyberbullying als auch die Wahrscheinlichkeit empathischer Reaktionen. Im Fokus der vorliegenden Studie mit 979 Schülerinnen und Schülern der 4.-8. Klassen (M=12.01, SD=1.68 Jahre, 55% weiblich) stand die Frage, ob Cyberbullies geringere Ausprägungen für affektive, kognitive und medienbasierte Empathie aufweisen als Unbeteiligte. Empathie wurde im Selbst- und Peerbericht erhoben. Hypothese...

Linear accelerator-based intensity-modulated total marrow irradiation technique for treatment of hematologic malignancies: a dosimetric feasibility study.

Science.gov (United States)

Yeginer, Mete; Roeske, John C; Radosevich, James A; Aydogan, Bulent

2011-03-15

To investigate the dosimetric feasibility of linear accelerator-based intensity-modulated total marrow irradiation (IM-TMI) in patients with hematologic malignancies. Linear accelerator-based IM-TMI treatment planning was performed for 9 patients using the Eclipse treatment planning system. The planning target volume (PTV) consisted of all the bones in the body from the head to the mid-femur, except for the forearms and hands. Organs at risk (OAR) to be spared included the lungs, heart, liver, kidneys, brain, eyes, oral cavity, and bowel and were contoured by a physician on the axial computed tomography images. The three-isocenter technique previously developed by our group was used for treatment planning. We developed and used a common dose-volume objective method to reduce the planning time and planner subjectivity in the treatment planning process. A 95% PTV coverage with the 99% of the prescribed dose of 12 Gy was achieved for all nine patients. The average dose reduction in OAR ranged from 19% for the lungs to 68% for the lenses. The common dose-volume objective method decreased the planning time by an average of 35% and reduced the inter- and intra- planner subjectivity. The results from the present study suggest that the linear accelerator-based IM-TMI technique is clinically feasible. We have demonstrated that linear accelerator-based IM-TMI plans with good PTV coverage and improved OAR sparing can be obtained within a clinically reasonable time using the common dose-volume objective method proposed in the present study. Copyright © 2011. Published by Elsevier Inc.

Functional MR imaging of the liver; Funktionelle MR-Tomographie der Leber

Energy Technology Data Exchange (ETDEWEB)

Wibmer, A.; Nolz, R.; Ba-Ssalamah, A. [Medizinische Universitaet Wien, Allgemeines Krankenhaus der Stadt Wien, Universitaetsklinik fuer Radiodiagnostik und Nuklearmedizin, Wien (Austria); Trauner, M. [Medizinische Universitaet Wien, Universitaetsklinik fuer Innere Medizin III, Klinische Abteilung fuer Gastroenterologie und Hepatologie, Wien (Austria)

2015-12-15

The diagnostics of diffuse liver disease traditionally rely on liver biopsies and histopathological analysis of tissue specimens. However, a liver biopsy is invasive and carries some non-negligible risks, especially for patients with decreased liver function and those requiring repeated follow-up examinations. Over the last decades, magnetic resonance imaging (MRI) has developed into a valuable tool for the non-invasive characterization of focal liver lesions and diseases of the bile ducts. Recently, several MRI methods have been developed and clinically evaluated that also allow the diagnostics and staging of diffuse liver diseases, e. g. non-alcoholic fatty liver disease, hepatitis, hepatic fibrosis, liver cirrhosis, hemochromatosis and hemosiderosis. The sequelae of diffuse liver diseases, such as a decreased liver functional reserve or portal hypertension, can also be detected and quantified by modern MRI methods. This article provides the reader with the basic principles of functional MRI of the liver and discusses the importance in a clinical context. (orig.) [German] Die Diagnostik diffuser Lebererkrankungen stuetzt sich klassisch auf die Leberbiopsie und deren histopathologische Analyse. Dieses Verfahren ist allerdings fuer die Patienten unangenehm und schmerzhaft, birgt v. a. bei Patienten mit Lebererkrankungen ein gewisses Risiko und eignet sich daher nur sehr eingeschraenkt zur Verlaufskontrolle bei chronischen Erkrankungen. Die Magnetresonanztomographie (MRT) der Leber nimmt schon jetzt eine zentrale Stellung in der Diagnostik von Raumforderungen der Leber und von Erkrankungen der Gallenwege ein. Darueber hinaus bietet dieses nichtinvasive Verfahren Moeglichkeiten, diffuse Erkrankungen des Leberparenchyms zu diagnostizieren und ihren Schweregrad abzuschaetzen, z. B. bei nichtalkoholischer Leberverfettung, Hepatitis, Leberfibrose, Zirrhose, Haemochromatose und Siderose und anderen. Folgen einer parenchymatoesen Lebererkrankung, wie die portale

Age-related normal uptake of {sup 99m}Tc-MDP in the lower spine

Energy Technology Data Exchange (ETDEWEB)

Sundkvist, G.M.G. [Dept. of Clinical Physiology, Centralsjukhuset, Kristianstad (Sweden); Lilja, B. [Dept. of Clinical Physiology, Universitetssjukhuset MAS, Malmoe (Sweden); Mattsson, S. [Dept. of Radiation Physics, Universitetssjukhuset MAS, Malmoe (Sweden)

1997-03-01

Aim: The uptake of {sup 99m}Tc-MDP in the lower spine was quantified in connection with ordinary bone scintigraphy. Methods: Fifty-seven women and seventy-two men (aged 20-69 y), with no signs of metabolic or malignant disease and no history of back pain or atraumatic fractures, were included in the study. Results: The women showed an increase in {sup 99m}Tc-MDP uptake from the age of 20 y to about 45 y with a decrease from the time of menopause. In contrast to women, the uptake in men showed a slight decrease from the age of 20 y to about 50 y and thereafter a more marked decrease was seen. The major difference between men and women is the high premenopausal uptake in the female skeleton. Conclusion: An understanding of age-related changes in {sup 99m}Tc-MDP uptake, which are indices of the skeletal metabolism, is of importance especially in prevention and treatment of osteoporosis, a common disorder in postmenopausal women. (orig.) [Deutsch] Ziel: In Verbindung mit einer routinemaessigen Skelettszintigraphie wurde die Speicherung von {sup 99m}Tc-MDP in der unteren Wirbelsaeule quantifiziert. Methoden: 57 Frauen und 22 Maenner (Alter von 20-69 Jahren) ohne metabolische oder boesartige Erkrankungen sowie ohne Rueckenschmerzen oder Wirbelsinterungen wurden in die Studien aufgenommen. Ergebnisse: Bei Frauen zeigte sich ein Anstieg der {sup 99m}Tc-MDP-Speicherung zwischen den Altersabschnitten 20 bis 45 Jahre und dann ein Abfall waehrend der Menopause. Im Gegensatz hierzu zeigte sich bei Maennern ein leichter Abfall der Speicherung vom 20. bis 50. Lebensjahr und danach eine noch staerkere Abnahme. Der Hauptunterschied zwischen den Geschlechtern ist die relativ hohe Speicherung im weiblichen Skelett praemenopausal. Schlussfolgerung: Das Verstaendnis der Altersbeziehungen der {sup 99m}Tc-MDP-Speicherung als Indikator des Knochenstoffwechsels ist fuer Praevention und Behandlung der postmenopausalen Osteoporose wichtig. (orig.)

Instrumentale Spielformeln und Vokale Verzierungen im 16.Jahrhundert

Directory of Open Access Journals (Sweden)

Göllner, Theodor

2001-12-01

Full Text Available In the music of the 16th century, stereotype four-note formulas are found in the instrumental as well as in the vocal idiom. Although frequently identical in appearance, their functions are very different. While indispensable in the instrumental idiom, particularly in keyboard music, where they represent the very essence of instruction in 15th-century organ treatises and fundamenta, they appear in vocal music only as additions to finished compositions or existing practices. What amounts to an absolute necessity in one case is merely an ornamental supplement in the other. In vocal music it is treated as a matter of performance carried out by a qualified soloist and limited to the musical centers of Italy. The present article raises the question as to how the genuinely instrumental and widely spread keyboard practice made its impact on the vocal ornaments of the singer, whose primary concern is the musical communication of language.

[de] Die in der Musik des 16. Jahrhunderts im Instrumentalen wie im Vokalen vorkommenden, meist viertönigen, stereotypen Formeln sind zwar in beiden Bereichen weitgehend identisch, doch von höchst unterschiedlicher Funktion. Während sie im Instrumentalen, besonders in der Tastenmusik, unverzichtbar sind und schon im 15. Jahrhundert den Kern der Orgeltraktate und Fundamenta bilden, treten sie im Vokalen zu einer fertigen Komposition oder bestehenden Praxis hinzu. Was im einen Fall eine unbedingte Notwendigkeit ist, wird im anderen zu einem nachträglichen Ornament, das sich oft erst bei der Aufftührung einstellt, den qualifizierten Solosänger voraussetzt und auf die musikalischen Zentren Italiens konzentriert war. Der Artikel versucht zu klären, wie sich das genuin instrumentale, allgemein verbreitete Tastenspiel auf die spezielle Verzierungskunst des Sängers auswirkt, dessen primäre Aufgabe es ist, Sprache musikalisch zu vermitteln.

Development of a plug-type IMS-MS instrument and its applications in resolving problems existing in in-situ detection of illicit drugs and explosives by IMS.

Science.gov (United States)

Du, Zhenxia; Sun, Tangqiang; Zhao, Jianan; Wang, Di; Zhang, Zhongxia; Yu, Wenlian

2018-07-01

Ion mobility spectrometry (IMS) which acts as a rapid analysis technique is widely used in the field detection of illicit drugs and explosives. Due to limited separation abilities of the pint-sized IMS challenges and problems still exist regarding high false positive and false negative responses due to the interference of the matrix. In addition, the gas-phase ion chemistry and special phenomena in the IMS spectra, such one substance showing two peaks, were not identified unambiguously. In order to explain or resolve these questions, in this paper, an ion mobility spectrometry was coupled to a mass spectrometry (IMS-MS). A commercial IMS is embedded in a custom-built ion chamber shell was attached to the mass spectrometer. The faraday plate of IMS was fabricated with a hole for the ions to passing through to the mass spectrometer. The ion transmission efficiency of IMS-MS was optimized by optimizing the various parameters, especially the distance between the faraday plate and the cone of mass spectrum. This design keeps the integrity of the two original instruments and the mass spectrometry still works with multimode ionization source (i.e., IMS-MS, ESI-MS, APCI-MS modes). The illicit drugs and explosive samples were analyzed by the IMS-MS with 63 Ni source. The results showed that the IMS-MS is of high sensitivity. The ionization mechanism of the illicit drug and explosive samples with 63 Ni source were systematically studied. In addition, the interferent which interfered the detection of cocaine was identified as dibutyl phthalate (DBP) by this platform. The reason why the acetone solution of amphetamine showed two peaks was explained. Copyright © 2018 Elsevier B.V. All rights reserved.

IMS applications analysis

Energy Technology Data Exchange (ETDEWEB)

RODACY,PHILIP J.; REBER,STEPHEN D.; SIMONSON,ROBERT J.; HANCE,BRADLEY G.

2000-03-01

This report examines the market potential of a miniature, hand-held Ion Mobility Spectrometer. Military and civilian markets are discussed, as well as applications in a variety of diverse fields. The strengths and weaknesses of competing technologies are discussed. An extensive Ion Mobility Spectrometry (IMS) bibliography is included. The conclusions drawn from this study are: (1) There are a number of competing technologies that are capable of detecting explosives, drugs, biological, or chemical agents. The IMS system currently represents the best available compromise regarding sensitivity, specificity, and portability. (2) The military market is not as large as the commercial market, but the military services are more likely to invest R and D funds in the system. (3) Military applications should be addressed before commercial applications are addressed. (4) There is potentially a large commercial market for rugged, hand-held Ion Mobility Spectrometer systems. Commercial users typically do not invest R and D funds in this type of equipment rather, they wait for off-the-shelf availability.

A Management Tool for Improvement (Improving) IMS Stations Performance

International Nuclear Information System (INIS)

Mohammad, D.; Pantin, A.; Quintana, E.

2011-01-01

IMS-Maintenance is a software under development by the personnel of ARN-CTBT office, intended for the technical management of IMS stations under ARN's responsibility. This software integrates the whole control of the equipment in an IMS station, including the management of consumables used in daily or periodic operation. It permits an easy retrieval (access) of the technical features, suppliers, etc. of each item of the equipment, as well as its maintenance history and scheduled task. Although this project is still in a starting phase, a preliminary version of this software is being used in radionuclide station RN01 (Buenos Aires), having already demonstrated its usefulness and potential for the improvement of IMS station management. (authors)

Radiological information management system (RadIMS)

International Nuclear Information System (INIS)

Oesterling, R.G.; Marko, S.A.; Tschaeche, A.N.

1991-01-01

Westinghouse Idaho Nuclear Company, Inc. (WINCO) is developing and implementing an information management system, known as RadIMS, to track and record personnel exposure to ionizing radiation. RadIMS has been designed to fulfill all the requirements of US Department of Energy (USDOE) Order 5480.11, ''Radiation Protection for Occupational Workers.'' This Order requires the contractor to maintain detailed radiation exposure records on all individuals who work at the facility. These records must be retrievable for the entire working life of the individual and be available to other USDOE contractors on request. To meet these general needs, RadIMS provides for retrieval of detailed, comprehensive individual exposure histories as well as the usual online interactions to accomplish day-today radiation protection operations. These two extremes of functionality require different approaches in the WINCO computing environment. The exposure histories include database text, paper, microfilm, and electronic bitmaps

Radiological information management system (RadIMS)

Energy Technology Data Exchange (ETDEWEB)

Oesterling, R.G.; Marko, S.A.; Tschaeche, A.N.

1991-08-19

Westinghouse Idaho Nuclear Company, Inc. (WINCO) is developing and implementing an information management system, known as RadIMS, to track and record personnel exposure to ionizing radiation. RadIMS has been designed to fulfill all the requirements of US Department of Energy (USDOE) Order 5480.11, Radiation Protection for Occupational Workers.'' This Order requires the contractor to maintain detailed radiation exposure records on all individuals who work at the facility. These records must be retrievable for the entire working life of the individual and be available to other USDOE contractors on request. To meet these general needs, RadIMS provides for retrieval of detailed, comprehensive individual exposure histories as well as the usual online interactions to accomplish day-today radiation protection operations. These two extremes of functionality require different approaches in the WINCO computing environment. The exposure histories include database text, paper, microfilm, and electronic bitmaps.

Radiological information management system (RadIMS)

Energy Technology Data Exchange (ETDEWEB)

Oesterling, R.G.; Marko, S.A.; Tschaeche, A.N.

1991-08-19

Westinghouse Idaho Nuclear Company, Inc. (WINCO) is developing and implementing an information management system, known as RadIMS, to track and record personnel exposure to ionizing radiation. RadIMS has been designed to fulfill all the requirements of US Department of Energy (USDOE) Order 5480.11, ``Radiation Protection for Occupational Workers.`` This Order requires the contractor to maintain detailed radiation exposure records on all individuals who work at the facility. These records must be retrievable for the entire working life of the individual and be available to other USDOE contractors on request. To meet these general needs, RadIMS provides for retrieval of detailed, comprehensive individual exposure histories as well as the usual online interactions to accomplish day-today radiation protection operations. These two extremes of functionality require different approaches in the WINCO computing environment. The exposure histories include database text, paper, microfilm, and electronic bitmaps.

Mesenteric panniculitis (MP) in CT. A predictor of malignancy?; Mesenteriale Pannikulitis (MP) im CT-Schnittbild. Ein Praediktor fuer ein Malignom?

Energy Technology Data Exchange (ETDEWEB)

Scheer, F.; Wissgott, C.; Andresen, R. [Westkuestenklinikum Heide (Germany). Inst. of Diagnostic and Interventional Radiology/Neuroradiology; Spunar, P. [Radiology Center Peine (Germany); Wiggermann, P. [University Hospital Regensburg (Germany). Dept. of Radiology

2016-10-15

The exact etiology of mesenteric panniculitis (MP) is still unknown and has been discussed in relation to different causes. The aim of this retrospective study was to evaluate a coherence between MP and malignancy. Retrospective analysis of consecutive CT abdomen examinations of 5595 patients in terms of MP over a period of 3 years was performed. To make the diagnosis of MP, three of five typical signs were obligatory: hyperdense mass lesion with intercalated nodules, a ''fat-ring sign'' or halo sign, a hyperdense pseudocapsule and displacement of bowel loops. The patient cohort (mean age: 64.7 years) consisted of 1974 (35.2 %) patients with histologically confirmed cancer and 3621 patients (64.8 %) without known underlying oncological disease. A total of 143 cases were diagnosed with MP (2.55 %). The average age of patients was 69.9 years with a male to female ratio of 2:1. In this group oncological disease was confirmed in 107 patients (74.8 %). In 36 patients with MP (25.2 %), no malignancy was present. In the group of patients with an underlying oncological disease, the prevalence of MP was 5.42 % and was significantly higher (p < 0.005) than in the patients with MP and without an oncological disease. The highest prevalence of MP (29 cases) was observed in non-Hodgkin lymphoma (22.6 %). The statistically calculated risk of a tumor disease in this collective is about 5 times higher if MP was demonstrated (p < 0.001). Based on the data of the collective, the risk of malignancy is five times higher in the presence of MP than in an inconspicuous mesentery. MP seems to frequently occur with non-Hodgkin lymphoma. MP can be seen on the basis of typical morphological features on the CT image. MP must be differentiated from a wide range of benign and malignant diseases of the mesentery.

The future of the IMS Learning Design specification: a critical look

NARCIS (Netherlands)

Sloep, Peter

2009-01-01

P. B. Sloep (2009). The future of the IMS Learning Design specification: a critical look. Presentation at the IMS Learning Design seminar 'The future of IMS Learning Design'. December, 10, 2009, Wollongong, Australia: University of Wollongong.

Vascular malformations in pediatrics; Vaskulaere Erkrankungen bei Neugeborenen, Saeuglingen und Kindern

Energy Technology Data Exchange (ETDEWEB)

Reith, W. [Abteilung fuer Neuroradiologie, Radiologische Universitaetsklinik Homburg/Saar (Germany); Abteilung fuer Neuroradiologie, Radiologische Universitaetsklinik, 66421, Homburg/Saar (Germany); Shamdeen, M.G. [Kinderklinik, Universitaetsklinikum Homburg/Saar (Germany)

2003-11-01

Vascular malformations are the cause of nearly all non-traumatic intracranial hemorrhage in children beyond the neonatal stage. Therefore, any child presenting with spontaneous intracranial hemorrhage should be evaluated for child abuse and for vascular malformations. Intracerebral malformations of the cerebral vasculature include vein of Galen malformations, arteriovenous malformation (AVM), cavernomas, dural arteriovenous fistulas, venous anomalies (DVA), and capillary teleangiectasies. Although a few familial vascular malformation have been reported, the majority are sporadic. Clinical symptoms, diagnostic and therapeutic options are discussed. (orig.) [German] Vaskulaere Malformationen sind die haeufigste Ursache einer intrakraniellen Blutung im Saeuglings- und Kindesalter. Deswegen sollte jedes Kind mit einer intrakraniellen Blutung auf eine vaskulaere Malformation und Kindesmisshandlung untersucht werden. Intrazerebrale Gefaessmalformationen beinhalten Vena-Galeni-Anomalien, arteriovenoese Malformationen (AVM), Kavernome, durale arteriovenoese Fisteln, kapillaere Teleangiektasien und venoese Anlagevarianten (DVA). Obwohl einige familiaere Gefaessmalformationen beschrieben sind, tritt die ueberwiegende Mehrzahl spontan auf. Die Klinik, Diagnostik und therapeutischen Optionen werden diskutiert. (orig.)

Im Wind / Mari Vallisoo ; tõlk. Gisbert Jänicke

Index Scriptorium Estoniae

Vallisoo, Mari, 1950-2013

2003-01-01

Sisu: Im Wind = Tuulega ; Zwei Frauen = Kaks naist ; In Gedanken an Aleksander Levin = aleksander Levinile mõteldes ; Jetzt im Dunkel = Nüüd pimedas ; Fragen = Küsimused ; Der Zwillingsbruder = Kaksikvend

Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors.

Science.gov (United States)

Abe, Makoto; Miyata, Satoshi; Nishimura, Seiichiro; Iijima, Kotaro; Makita, Masujiro; Akiyama, Futoshi; Iwase, Takuji

2011-10-01

Malignant phyllodes tumor of the breast is a rare neoplasm for which clinical findings remain insufficient for determination of optimal management. We examined the clinical behavior of these lesions in an attempt to determine appropriate management. We evaluated long-term outcome and clinical characteristics of malignant phyllodes tumors arising from fibroadenomas of the breast. A total of 173 patients were given a diagnosis of phyllodes tumor and underwent surgery at the Cancer Institute Hospital in Japan between January 1980 and December 1999. Of these patients, 39 (22.5%) were given a diagnosis of malignant phyllodes tumor; in three of these cases, detailed medical records were lost. Malignant phyllodes tumors were classified into two groups based on history of malignant transformation. Of the 36 malignant cases, 11 (30.6%) were primary and were given a diagnosis of fibroadenoma, experienced recurrence during the follow-up period, and were diagnosed with malignant phyllodes tumor (cases with a history of fibroadenoma). The other group was defined as cases without history of fibroadenoma and in whom lesions initially occurred as malignant phyllodes tumors. Based on differences between the two groups, overall survival curves were plotted using the Kaplan–Meier method, and statistical comparisons were performed using the log-rank test and Peto and Peto’s test. The outcome of cases with history of fibroadenoma was significantly better than that of cases without history of fibroadenoma. Patients with malignant phyllodes tumors but without prior history of malignant transformation who exhibit rapid growth within 6 months require aggressive treatment.

Transplantate und Implantate im Mittelohrbereich - Teil 1 (Stand 2002)

Science.gov (United States)

Kempf, Hans-Georg; Lenarz, Thomas; Eckert, Karl-Ludwig

In Deutschland leben ungefähr 12 Millionen Menschen, die an einer ein- oder beidseitigen Schwerhörigkeit leiden. Diese kann angeboren oder im Laufe des Lebens erworben sein. Klinisch und therapeutisch wichtig ist die Unterscheidung, ob die Ursache der Schwerhörigkeit im Bereich des Mittelohres, d. h. der Schallübertragung, oder im Bereich des Innenohres, der Hörnerven und der zentralen Hörbahnabschnitte, d. h. der Schallempfindung, liegt. 2,5 Millionen Schwerhörige haben dabei das Problem der Schallübertragung, d.h. die Störung liegt im Mittelohrbereich, und hier kann man in der Regel mit operativen, mikrochirurgisch durchgeführten Massnahmen helfen [1, 2]. Im Vordergrund steht als Ursache hier die chronische Mittelohrentzündung, die sich als Perforation des Trommelfells, als Defekt oder Unterbrechung der Gehörknöchelchen oder auch als Cholesteatom, einer sogenannte Knocheneiterung äussern kann [3]. Therapeutisch und damit als Prinzip der operativen Hörverbesserung steht primär der Verschluss des Trommelfells oder eine Rekonstruktion der Gehörknöchelchen an.

Stenting und technische Stentumgebung

Science.gov (United States)

Hoffstetter, Marc; Pfeifer, Stefan; Schratzenstaller, Thomas; Wintermantel, Erich

In hoch entwickelten Industrieländern stehen laut Weltgesundheitsorganisation (WHO) Herz-Kreislauf-Erkrankungen und speziell die Koronare Herzkrankheit (KHK) an erster Stelle der Todesursachen. In Deutschland betrug die Zahl der erfassten, an KHK erkrankten Personen ohne Berücksichtigung der Dunkelziffer allein im Jahre 2001 über 473.000. Die KHK war im Jahre 2003 mit 92.673 erfassten Todesfällen immer noch die häufigste Todesursache, obgleich in Deutschland die Häufigkeit der Koronarinterventionen zur Behandlung der KHK zwischen 1984 und 2003 um fast das 80fache von 2.809 auf 221.867 Eingriffe pro Jahr gestiegen ist [1]. Neben der hohen Zahl an Todesfällen haben die betroffenen Personen durch chronische Schmerzen und eingeschränkte körperliche Leistungsfähigkeit zusätzlich eine starke Beeinträchtigung der Lebensqualität [2].In Folge dessen wird die erkrankte Person häufig zum Pflegefall was neben den gesundheitlichen Aspekten auch eine sozioökonomische Komponente in Form der fehlenden Arbeitskraft und den auftretenden Pflegekosten nach sich zieht. Die Kosten für die Behandlung der KHK in Deutschland beliefen sich im Jahre 2002 laut Statistischem Bundesamt auf rund 6,9 Mrd. €. Verglichen mit ähnlichen Zahlen der USA dürfte sich der entstandene Schaden für die deutsche Volkswirtschaft im zwei- bis dreistelligen Milliardenbereich bewegen [3].

Imaging malignant and apparent malignant transformation of benign gynaecological disease

Energy Technology Data Exchange (ETDEWEB)

Lee, A.Y.; Poder, L.; Qayyum, A.; Wang, Z.J.; Yeh, B.M. [Department of Radiology, University of California San Francisco, San Francisco, CA (United States); Coakley, F.V., E-mail: Fergus.Coakley@radiology.ucsf.ed [Department of Radiology, University of California San Francisco, San Francisco, CA (United States)

2010-12-15

Common benign gynaecological diseases, such as leiomyoma, adenomyosis, endometriosis, and mature teratoma, rarely undergo malignant transformation. Benign transformations that may mimic malignancy include benign metastasizing leiomyoma, massive ovarian oedema, decidualization of endometrioma, and rupture of mature teratoma. The aim of this review is to provide a contemporary overview of imaging findings in malignant and apparent malignant transformation of benign gynaecological disease.

Coherent ambient infrasound recorded by the global IMS network

Science.gov (United States)

Matoza, R. S.; Landes, M.; Le Pichon, A.; Ceranna, L.; Brown, D.

2011-12-01

The International Monitoring System (IMS) includes a global network of infrasound arrays, which is designed to detect atmospheric nuclear explosions anywhere on the planet. The infrasound network also has potential application in detection of natural hazards such as large volcanic explosions and severe weather. Ambient noise recorded by the network includes incoherent wind noise and coherent infrasound. We present a statistical analysis of coherent infrasound recorded by the IMS network. We have applied broadband (0.01 to 5 Hz) array processing systematically to the multi-year IMS historical dataset (2005-present) using an implementation of the Progressive Multi-Channel Correlation (PMCC) algorithm in log-frequency space. We show that IMS arrays consistently record coherent ambient infrasound across the broad frequency range from 0.01 to 5 Hz when wind-noise levels permit. Multi-year averaging of PMCC detection bulletins emphasizes continuous signals such as oceanic microbaroms, as well as persistent transient signals such as repetitive volcanic, surf, or anthropogenic activity (e.g., mining or industrial activity). While many of these continuous or repetitive signals are of interest in their own right, they may dominate IMS array detection bulletins and obscure or complicate detection of specific signals of interest. The new PMCC detection bulletins have numerous further applications, including in volcano and microbarom studies, and in IMS data quality assessment.

Gruppenbezogene Menschenfeindlichkeit im Sport in Sachsen-Anhalt

OpenAIRE

Delto, Hannes; Tzschoppe, Petra

2016-01-01

Mit der Querschnittsstudie „Wir und die Anderen – Gruppenbezogene Menschenfeindlichkeit im organisierten Sport in Sachsen-Anhalt“ wurde das Syndrom Gruppenbezogener Menschenfeindlichkeit im organisierten Sport untersucht. Das Konzept der Gruppenbezogenen Menschenfeindlichkeit – ausgehend von einer Ideologie der Ungleichwertigkeit – wurde von Prof. Wilhelm Heitmeyer (Universität Bielefeld) entwickelt. Die Ergebnisse ermöglichen explizite Aussagen über Ausmaß und Ursachen Gruppenbezogener Mensc...

Freie Lerninhalte im Internet mit Studierenden recherchieren, kommentieren und kompilieren. Zur Gestaltung der online-Selbstlernangebote im hr-Funkkolleg Philosophie

Directory of Open Access Journals (Sweden)

Jakob Krebs

2017-03-01

Full Text Available Wie lassen sich online frei verfügbare Bildungsinhalte mit Studierenden so zusammenstellen, dass sie als thematisch sortierte Selbstlernmaterialien unkompliziert gefunden werden können – sei es von anderen Studierenden, interessierten Laien oder auch von Lehrkräften in Bildungsinstitutionen? Der vorliegende Werkstattbericht rekonstruiert ein Lernszenario, in dem Studierende vorhandene Materialien im Internet recherchierten, kommentierten und kompilierten, um ein Online-Zusatzangebot zu den Radiosendungen im hr-Funkkolleg Philosophie 2014/15 zu erstellen. Die Rahmenbedingungen dieser ungewöhnlichen universitären Kooperation mit dem Rundfunk werden im ersten Abschnitt vorgestellt. Der zweite Abschnitt skizziert das didaktische Design zusammen mit dem Projektstrukturplan eines produktorientierten kollaborativen Lernsettings mit Wiki-Einsatz. Im dritten Abschnitt werden der Lernerfolg bei den Studierenden sowie einige Herausforderungen benannt, die u. a. in der Abschlussevaluierung zur Sprache kamen. Der vierte Abschnitt macht die Projekterfahrungen für reguläre Lehr- und Lern-Szenarien fruchtbar, in denen nicht nur Studierende mit didaktischen Interessen durch die gemeinsame Gestaltung von Internetangeboten fachlich und methodisch profitieren können. Mit dem Bericht wird somit u. a. veranschaulicht, wie sich Ansätze von Blended, Peer-Assisted und Service Learning produktiv kombinieren lassen.

Thermische Verletzungen im Kindesalter: Eine retrospektive Kohortenstudie von 212 Fällen

OpenAIRE

Sperling, Patrik Leonhart

2012-01-01

Anhand einer retrospektiven Datenanalyse sollen Verteilungsmuster von Verbrennungen und Verbrühungen bezogen auf Alter und Geschlecht untersucht werden. Erfasst wurden 212 Patienten im Alter von 0 bis 16 Jahren betrachtet, die im Zeitraum vom 01.01.2004 bis zum 31.12.2009 auf Grund einer thermischen Verletzung stationär im Universitätsklinikum Würzburg der Julius-Maximilians-Universität Würzburg behandelt wurden. Den größten Anteil thermischer Verletzungen im Kindesalter stellen Verbrühungen ...

Sequence-specific DNA alkylation by tandem Py-Im polyamide conjugates.

Science.gov (United States)

Taylor, Rhys Dylan; Kawamoto, Yusuke; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

2014-09-01

Tandem N-methylpyrrole-N-methylimidazole (Py-Im) polyamides with good sequence-specific DNA-alkylating activities have been designed and synthesized. Three alkylating tandem Py-Im polyamides with different linkers, which each contained the same moiety for the recognition of a 10 bp DNA sequence, were evaluated for their reactivity and selectivity by DNA alkylation, using high-resolution denaturing gel electrophoresis. All three conjugates displayed high reactivities for the target sequence. In particular, polyamide 1, which contained a β-alanine linker, displayed the most-selective sequence-specific alkylation towards the target 10 bp DNA sequence. The tandem Py-Im polyamide conjugates displayed greater sequence-specific DNA alkylation than conventional hairpin Py-Im polyamide conjugates (4 and 5). For further research, the design of tandem Py-Im polyamide conjugates could play an important role in targeting specific gene sequences. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Information Management System (Ims) For Gender Mainstreaming In ...

African Journals Online (AJOL)

Information Management System (IMS) is an essential tool in supporting the provision of information needed for planning and decision making in any organization. Proper IMS facilitates the smooth flow of information both vertical and horizontal. This paper presents the findings of a survey on information needs of the Gender ...

Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells

International Nuclear Information System (INIS)

Mulvey, Hillary E.; Chang, Audrey; Adler, Jason; Del Tatto, Michael; Perez, Kimberly; Quesenberry, Peter J.; Chatterjee, Devasis

2015-01-01

Extracellular vesicles (EVs) are secreted from many cells, carrying cargoes including proteins and nucleic acids. Research has shown that EVs play a role in a variety of biological processes including immunity, bone formation and recently they have been implicated in promotion of a metastatic phenotype. EVs were isolated from HCT116 colon cancer cells, 1459 non-malignant colon fibroblast cells, and tumor and normal colon tissue from a patient sample. Co-cultures were performed with 1459 cells and malignant vesicles, as well as HCT116 cells and non-malignant vesicles. Malignant phenotype was measured using soft agar colony formation assay. Co-cultures were also analyzed for protein levels using mass spectrometry. The importance of 14-3-3 zeta/delta in transfer of malignant phenotype was explored using siRNA. Additionally, luciferase reporter assay was used to measure the transcriptional activity of NF-κB. This study demonstrates the ability of EVs derived from malignant colon cancer cell line and malignant patient tissue to induce the malignant phenotype in non-malignant colon cells. Similarly, EVs derived from non-malignant colon cell lines and normal patient tissue reversed the malignant phenotype of HCT116 cells. Cells expressing an EV-induced malignant phenotype showed increased transcriptional activity of NF-κB which was inhibited by the NF--κB inhibitor, BAY117082. We also demonstrate that knock down of 14-3-3 zeta/delta reduced anchorage-independent growth of HCT116 cells and 1459 cells co-cultured with HCT derived EVs. Evidence of EV-mediated induction of malignant phenotype, and reversal of malignant phenotype, provides rational basis for further study of the role of EVs in tumorigenesis. Identification of 14-3-3 zeta/delta as up-regulated in malignancy suggests its potential as a putative drug target for the treatment of colorectal cancer

Calibración de imágenes de radares meteorológicos

Directory of Open Access Journals (Sweden)

Virgilio Santander Socorras Quintero

2014-04-01

Full Text Available En este documento se ilustran las técnicas de fusión de imágenes para complementar y calibrar la información meteorológica presente en imágenes de radares terrestres con el uso de imágenes satelitales meteorológicas. Para realizar la calibración de las imágenes de radares terrestres se implementó un método de fusión de imágenes basado en la herramienta matemática transformada wavelet discreta. Ya que existe una familia de wavelets, es necesario determinar cuál wavelet ofrece el mejor resultado; para esto se determina la correlación existente entre los resultados de fusión de diferentes wavelets y las imágenes uti-lizadas en cada fusión. Se define una metodología para selección de umbral global de segmentación y una metodología para realizar la calibración de las imágenes de radares terrestres. Siguiendo la metodología de calibración de imágenes, se generan algunos resultados y se muestran sus ventajas.

Hemato-oncological imaging. Importance of hybrid procedures; Haematoonkologische Bildgebung. Stellenwert der Hybridverfahren

Energy Technology Data Exchange (ETDEWEB)

Mayerhoefer, M.E. [Univ.-Klinik fuer Radiologie und Nuklearmedizin, Abteilung fuer Allgemeine und Kinderradiologie, Medizinische Universitaet Wien, Wien (Austria); Haug, A. [Univ.-Klinik fuer Radiologie und Nuklearmedizin, Abteilung fuer Nuklearmedizin, Medizinische Universitaet Wien, Wien (Austria)

2016-07-15

Biomedical imaging procedures play a major role in hemato-oncological diseases with respect to pre-therapeutic staging and assessment of treatment response. Originally, the therapeutic management was the domain of computed tomography (CT) and whole-body magnetic resonance imaging (MRI). Over the last decade these purely morphological techniques have gradually been replaced by hybrid imaging techniques, such as positron emission tomography-CT (PET/CT) and PET/MRI, which also provide metabolic and functional information. For lymphomas, the PET tracer 18F-fluorodeoxyglucose (18 F-FDG) is meanwhile so well-established that its use is a cornerstone of the Lugano classification; however, for multiple myeloma the search for an optimal PET tracer that can also detect early disease stages is still ongoing. Functional MRI techniques, such as diffusion-weighted imaging (DWI), perfusion-weighted imaging and dynamic contrast-enhanced imaging have shown promising results for both lymphomas and multiple myelomas. The PET/MRI technique can combine the different types of information due to its truly multiparametric approach. In the future PET/MRI could possibly become the hybrid imaging technique of choice for hemato-oncological diseases. (orig.) [German] Bildgebende Verfahren spielen bei haematoonkologischen Erkrankungen eine wesentliche Rolle fuer das Staging vor der Therapie und die Beurteilung des Therapieansprechens. Urspruenglich waren es v. a. die CT und die Ganzkoerper-MRT, welche die fuer das therapeutische Management relevanten Informationen lieferten. Im letzten Jahrzehnt erfolgte bei dieser Gruppe von Tumorerkrankungen jedoch eine Abkehr von den rein morphologischen Verfahren hin zu den Hybridverfahren Positronenemissionstomographie(PET)-CT und PET-MRT, welche auch metabolische und funktionelle Informationen liefern. Bei Lymphomen steht der PET-Tracer {sup 18}F-Fluordesoxyglukose ({sup 18}F-FDG) mittlerweile im Zentrum der Diagnostik und ist auch fest in der aktuellen

Choosing the Right Free IM Providers and Clients for Your Library

Science.gov (United States)

Izenstark, Amanda K.

2009-01-01

With virtual library services increasing, public services librarians may find themselves with questions such as: What instant messaging services (IM) are available? Which IM service would best suit my patrons' needs? Which IM service best suits my library's technology profile? This column describes the features and functionality of major instant…

World-wide developments in motor vehicle inspection/maintenance (I/M) programs

Energy Technology Data Exchange (ETDEWEB)

Klausmeier, R. [Consulting Inc., Austin, TX (United States); Kishan, S. [Radian Corporation, Austin, TX (United States)

1995-12-31

Motor vehicles contribute much to urban air pollution. As a result, most governments have enacted emission standards that significantly lower pollutant emission levels from new motor vehicles. For example, vehicles built in the United States emit 95 % fewer pollutants than uncontrolled vehicles when they are new. However, studies indicate that proper maintenance is needed to obtain the full benefit of vehicle emission controls. Furthermore, there is evidence that a significant percentage of the vehicle fleet is not properly maintained. This has led to the creation of motor vehicle Inspection/Maintenance (I/M) Programs. I/M programs inspect vehicles for indications that they are emitting excessive quantities of pollutants. Vehicles that fail the inspection must be repaired in order to comply with program requirements. The first I/M programs were implemented in the United States in the early 1970s. With substantial urging from the federal government, most of the U.S. states with severe air pollution problems have implemented I/M programs. Recently, with the passage of the U.S. Clean Air Act Amendments of 1990, many states have been required to significantly upgrade the performance and coverage of their I/M programs. I/M programs also have been implemented in Europe and recently in Asia. This presentation reviews developments in I/M programs for light-duty gasoline powered vehicles. Developments in I/M programs for diesel powered vehicles are briefly described. (author)

World-wide developments in motor vehicle inspection/maintenance (I/M) programs

Energy Technology Data Exchange (ETDEWEB)

Klausmeier, R [Consulting Inc., Austin, TX (United States); Kishan, S [Radian Corporation, Austin, TX (United States)

1996-12-31

Motor vehicles contribute much to urban air pollution. As a result, most governments have enacted emission standards that significantly lower pollutant emission levels from new motor vehicles. For example, vehicles built in the United States emit 95 % fewer pollutants than uncontrolled vehicles when they are new. However, studies indicate that proper maintenance is needed to obtain the full benefit of vehicle emission controls. Furthermore, there is evidence that a significant percentage of the vehicle fleet is not properly maintained. This has led to the creation of motor vehicle Inspection/Maintenance (I/M) Programs. I/M programs inspect vehicles for indications that they are emitting excessive quantities of pollutants. Vehicles that fail the inspection must be repaired in order to comply with program requirements. The first I/M programs were implemented in the United States in the early 1970s. With substantial urging from the federal government, most of the U.S. states with severe air pollution problems have implemented I/M programs. Recently, with the passage of the U.S. Clean Air Act Amendments of 1990, many states have been required to significantly upgrade the performance and coverage of their I/M programs. I/M programs also have been implemented in Europe and recently in Asia. This presentation reviews developments in I/M programs for light-duty gasoline powered vehicles. Developments in I/M programs for diesel powered vehicles are briefly described. (author)

MR imaging of the kidneys: new diagnostic strategies; MR-Bildgebung der Nieren. Neue Ansaetze in der Diagnostik

Energy Technology Data Exchange (ETDEWEB)

Schoenberg, S.O.; Knopp, M.V.; Bock, M.; Floemer, F.; Essig, M.; Hawighorst, H.; Kaick, G. van [Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt Radiologische Diagnostik; Kallinowski, F. [Heidelberg Univ. (Germany). Chirurgische Universitaetsklinik; Just, A. [Heidelberg Univ. (Germany). 1. Physiologisches Inst.; Laub, G. [Siemens AG, Erlangen (Germany). Unternehmensbereich Medizinische Technik; Prince, M.R [Michigan Univ., Ann Arbor, MI (United States). Dept. of Radiology

1999-05-01

Aim: New diagnostic strategies for evaluation of the kidney by fast MR imaging of renal morphology, multiphase 3D gadolinium MR angiography, MR urography and MR flow measurements. A signal MR examination is designed to grade renovascular disease and assess the hemodynamic and functional significance, detect and characterize renal lesions and evaluate the urinary tract. Results: The combined analysis of morphologic and functional data allows reliable assessment of renal artery stenosis, benign and malignant renal masses and diseases of the renal collecting system and ureters, as well as congenital abnormalities in good agreement to the results of conventional imaging modalities. The improved tissue contrast and additional functional information compensates for the disadvantage of a lower spatial resolution. Conclusion: Combined morphologic and functional MR examination represents a reliable, non-invasive and cost-effective alternative imaging modality for comprehensive diagnostic evaluation of renal disease. (orig.) [Deutsch] Fragestellung: Darstellung neuer diagnostischer Moeglichkeiten im Bereich der Niere mittels schneller Magnetresonanz (MR)-Bildgebung. Methodik: Vorgestellt wird ein kombiniertes morphologisches und funktionelles Untersuchungskonzept bestehend aus schneller morphologischer Bildgebung, multiphasischer 3D-Gadolinium-MR-Angiographie, MR-Urographie und MR-Flussmessung. In einer einzigen MR-Untersuchung sollen vaskulaere Erkrankungen erfasst, eingestuft und auf ihre haemodynamische und funktionelle Signifikanz ueberprueft werden, renale Laesionen detektiert und differenziert sowie die Harnabflusswege beurteilt werden. Ergebnisse: Durch Integration der gewonnenen morphologischen und funktionellen Daten lassen sich Nierenarterienstenosen, benigne und maligne renale Tumoren, Harnabflussstoerungen und kongenitale Fehlbildungen mit aehnlicher Genauigkeit wie in den konventionellen radiologischen Verfahren erfassen. Der Nachteil der geringeren raeumlichen

Respuestas faciales ante imágenes de advertencia de tabaco

Directory of Open Access Journals (Sweden)

M. A. Muñoz

Full Text Available Resumen En 2003, la Comisión Europea propuso una serie de advertencias visuales para ser incluidas en los embalajes de tabaco, con el objetivo de motivar a los fumadores a dejar de fumar y promover actitudes negativas hacia el tabaco. El objetivo de este estudio fue evaluar el impacto de las advertencias sanitarias mediante autoinformes y medidas psicofisiológicas. Cincuenta sujetos sanos (19-23 años visionaron un conjunto de treinta y seis imágenes de diferente contenido emocional y veinticuatro del banco de imágenes preventivas propuestas por la Comisión Europea. Se registró la actividad eléctrica de los músculos cigomático mayor y corrugador mientras los sujetos visionaban estas imágenes. A continuación, los participantes evaluaban las imágenes en las dimensiones de agradabilidad y activación. Los resultados muestran una mayor actividad eléctrica del musculo corrugador ante la presentación de imágenes desagradables comparadas con advertencias desagradables incluidas en los paquetes de tabaco. Estos resultados sugieren que la campaña preventiva podría beneficiarse de imágenes preventivas más impactantes, promoviendo así la activación del sistema motivacional evitativo/defensivo.

Jung und Alt im Dialog

Directory of Open Access Journals (Sweden)

Caroline Baetge

2012-04-01

Full Text Available Rezension zu: Kupser, Thomas, und Ida Pöttinger, Hrsg. 2011. Mediale Brücken: Generationen im Dialog durch aktive Medienarbeit. Gesellschaft - Altern - Medien 3. München: kopaed.

Second malignancy in relation to treatment modality of primary malignancy

International Nuclear Information System (INIS)

Singh, Harpreet; Kaur, Parveen; Vashistha, Rajesh; Singh, Jaskaran; Passi, Kamlesh; Jain, Satish

2001-01-01

Second malignant tumors among long-term survivors are a sensitive indicator of successful oncologic treatment, particularly in this area of multimodal therapy. 11 patients of abdominopelvic primary malignancy were detected to have a second malignancy of different pathology, and at a different site. These patients were assessed regarding treatment modality of initial cancer and time gap between the first and second malignancy. Lack of proper cancer registries, illiteracy, and lack of resources lead to poor patient follow-up; therefore population based studies is not possible

Developing an effective IM/IT strategy.

Science.gov (United States)

Kramer, Sarah; Walker, Joanne; Falk, Will

2009-01-01

Healthcare organizations and systems around the world lag far behind banking, manufacturing, travel and other industries in their use of information management/information technology (IM/IT) to deliver high-quality products and services. Across Canada, healthcare organizations, as well as governments, understand that information and information technology are needed to deliver quality care and to sustain our publicly funded health system. However, insufficient funding, few experienced resources, lack of strong leadership and absence of clear business/clinical rationale have restricted innovation and advancement in the use of IM/IT to improve healthcare delivery and patient outcomes.

Real-time resource availability signalling in IMS-based networks

NARCIS (Netherlands)

Ozcelebi, T.; Radovanovic, I.; Lukkien, J.J.

2007-01-01

The emerging converged IP multimedia subsystem (IMS) allows the use of unlicensed, nondedicated and nondeterministic computer access networks for delivering IP multimedia services. To provide end-to-end quality-of-service (QoS) over such networks combined with the IMS core network, for resource

Medida Interpessoal de Psicopatia (IM-P: estudo preliminar no contexto brasileiro Interpersonal Measure of Psychopathy (IM-P: preliminary study in the Brazilian context

Directory of Open Access Journals (Sweden)

Tárcia Rita Davoglio

2011-01-01

Full Text Available INTRODUÇÃO: A observação direta do comportamento interpessoal é um recurso importante na descrição e diagnóstico da personalidade psicopática. A Medida Interpessoal de Psicopatia (Interpersonal Measure of Psychopathy, IM-P é um instrumento psicométrico composto por 21 itens, desenvolvido para ser utilizado em associação com outras escalas de avaliação da psicopatia. Foca-se, especificamente, nos comportamentos interpessoais e aspectos não verbais evidentes na interação do entrevistador com indivíduos que apresentam características psicopáticas. OBJETIVO: Descrever resultados preliminares sobre a investigação de aspectos interpessoais da psicopatia mediante a utilização da IM-P, incluindo as etapas de tradução/adaptação e avaliação de confiabilidade interavaliadores da IM-P, em uma amostra de adolescentes brasileiros. MÉTODO: Trata-se de estudo transversal, descritivo e correlacional realizado com 20 adolescentes masculinos cumprindo medida socioeducativa com privação de liberdade na Região Metropolitana de Porto Alegre (RS. Após os procedimentos de tradução da escala, treinamento dos pesquisadores e teste piloto por meio de uma entrevista semiestruturada, a IM-P foi pontuada por três juízes independentes. RESULTADOS: Os resultados estatísticos, obtidos através do coeficiente de concordância de Kendall, revelaram grau de concordância interavaliadores elevado e satisfatório para os escores totais da IM-P (W = 0,84; p INTRODUCTION: The direct observation of interpersonal behaviors is an important resource in the description and diagnosis of the psychopathic personality. The Interpersonal Measure of Psychopathy (IM-P is a psychometric instrument comprised of 21 items, designed to be applied in association with other instruments that also evaluate psychopaths. It focuses specifically on interpersonal and non-verbal behaviors that become evident during the interaction between the interviewer and individuals

Address Translation Problems in IMS Based Next Generation Networks

Directory of Open Access Journals (Sweden)

Balazs Godor

2006-01-01

Full Text Available The development of packed based multimedia networks reached a turning point when the ITU-T and the ETSIhave incorporated the IMS to the NGN. With the fast development of mobile communication more and more services andcontent are available. In contrast with fix network telephony both the services and the devices are personalized in the “mobileworld”. Services, known from the Internet - like e-mail, chat, browsing, presence, etc. – are already available via mobiledevices as well. The IMS originally wanted to exploit both the benefits of mobile networks and the fancy services of theInternet. But today it is already more than that. IMS is the core of the next generation telecommunication networks and abasis for fix-mobile convergent services. The fact however that IMS was originally a “mobile” standard, where IPv6 was notoddity generated some problems for the fix networks, where IPv4 is used. In this article I give an overview of these problemsand mention some solutions as well.

Malignant mesothelioma

OpenAIRE

Parker Robert J; Moore Alastair J; Wiggins John

2008-01-01

Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10–20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting featu...

Gesundheit und Pflege im Alter

OpenAIRE

Pfaff, Martin

1989-01-01

Gesundheit und Pflege im Alter : d. Gesundheitsreformgesetz (GRG) ; Möglichkeiten, Grenzen u. weitere Vorschläge / Martin Pfaff ; Klaus Deimer. - In: Expertengespräch "Pflege in der Familie". - Augsburg, 1989. - Getr. Zählung

Digitalisierung im Verteilnetz: Evolution oder Revolution anhand konkreter Beispiele

Science.gov (United States)

Krone, Oliver; Bachmann, Maurus

Durch die Integration der neuen erneuerbaren Energien steht das Stromnetz vor großen Herausforderungen. Das Energiesystem als Gesamtes und die Verteilnetze im Speziellen werden smart. Anhand konkreter Beispiele wird aufgezeigt, wie die Digitalisierung im Elektrizitätsnetz voranschreitet. Diese Entwicklung ist eine Evolution, nicht aber eine Revolution.

THOR Ion Mass Spectrometer instrument - IMS

Science.gov (United States)

Retinò, Alessandro; Kucharek, Harald; Saito, Yoshifumi; Fraenz, Markus; Verdeil, Christophe; Leblanc, Frederic; Techer, Jean-Denis; Jeandet, Alexis; Macri, John; Gaidos, John; Granoff, Mark; Yokota, Shoichiro; Fontaine, Dominique; Berthomier, Matthieu; Delcourt, Dominique; Kistler, Lynn; Galvin, Antoniette; Kasahara, Satoshi; Kronberg, Elena

2016-04-01

Turbulence Heating ObserveR (THOR) is the first mission ever flown in space dedicated to plasma turbulence. Specifically, THOR will study how turbulent fluctuations at kinetic scales heat and accelerate particles in different turbulent environments within the near-Earth space. To achieve this goal, THOR payload is being designed to measure electromagnetic fields and particle distribution functions with unprecedented resolution and accuracy. Here we present the Ion Mass Spectrometer (IMS) instrument that will measure the full three-dimensional distribution functions of near-Earth main ion species (H+, He+, He++ and O+) at high time resolution (~ 150 ms for H+ , ~ 300 ms for He++) with energy resolution down to ~ 10% in the range 10 eV/q to 30 keV/q and angular resolution ~ 10°. Such high time resolution is achieved by mounting multiple sensors around the spacecraft body, in similar fashion to the MMS/FPI instrument. Each sensor combines a top-hat electrostatic analyzer with deflectors at the entrance together with a time-of-flight section to perform mass selection. IMS electronics includes a fast sweeping high voltage board that is required to make measurements at high cadence. Ion detection includes Micro Channel Plates (MCP) combined with Application-Specific Integrated Circuits (ASICs) for charge amplification, discrimination and time-to-digital conversion (TDC). IMS is being designed to address many of THOR science requirements, in particular ion heating and acceleration by turbulent fluctuations in foreshock, shock and magnetosheath regions. The IMS instrument is being designed and will be built by an international consortium of scientific institutes with main hardware contributions from France, USA, Japan and Germany.

Aggregation und Management von Metadaten im Kontext von Europeana

Directory of Open Access Journals (Sweden)

Gerda Koch

2017-09-01

Full Text Available Mit dem In-Beziehung-Setzen und Verlinken von Daten im Internet wird der Weg zur Umsetzung des semantischen Webs geebnet. Erst die semantische Verbindung von heterogenen Datenbeständen ermöglicht übergreifende Suchvorgänge und späteres „Machine Learning“. Im Artikel werden die Aktivitäten der Europäischen Digitalen Bibliothek im Bereich des Metadatenmanagements und der semantischen Verlinkung von Daten skizziert. Dabei wird einerseits ein kurzer Überblick zu aktuellen Forschungsschwerpunkten und Umsetzungsstrategien gegeben, und darüber hinaus werden einzelne Projekte und maßgeschneiderte Serviceangebote für naturhistorische Daten, regionale Kultureinrichtungen und Audiosammlungen beschrieben.

Sexting im Schulumfeld

Directory of Open Access Journals (Sweden)

Barbara Buchegger

2015-03-01

Full Text Available Wir wollten es einfach wissen. Wie steht es nun mit diesem "Sexting" – also der Übermittlung von Nacktaufnahmen, die Jugendliche untereinander teilen? Stimmt unser Eindruck aus den Workshops in Schulen, dass es bereits ein "übliches Verhalten" der Jugendlichen geworden ist? Saferinternet.at hat im November/Dezember 2014 eine Studie durch das Institut für Jugendkulturforschung rund um das Thema "Sexting" in Auftrag gegeben.

A two-stage extraction procedure for insensitive munition (IM) explosive compounds in soils.

Science.gov (United States)

Felt, Deborah; Gurtowski, Luke; Nestler, Catherine C; Johnson, Jared; Larson, Steven

2016-12-01

The Department of Defense (DoD) is developing a new category of insensitive munitions (IMs) that are more resistant to detonation or promulgation from external stimuli than traditional munition formulations. The new explosive constituent compounds are 2,4-dinitroanisole (DNAN), nitroguanidine (NQ), and nitrotriazolone (NTO). The production and use of IM formulations may result in interaction of IM component compounds with soil. The chemical properties of these IM compounds present unique challenges for extraction from environmental matrices such as soil. A two-stage extraction procedure was developed and tested using several soil types amended with known concentrations of IM compounds. This procedure incorporates both an acidified phase and an organic phase to account for the chemical properties of the IM compounds. The method detection limits (MDLs) for all IM compounds in all soil types were regulatory risk-based Regional Screening Level (RSL) criteria for soil proposed by the U.S. Army Public Health Center. At defined environmentally relevant concentrations, the average recovery of each IM compound in each soil type was consistent and greater than 85%. The two-stage extraction method decreased the influence of soil composition on IM compound recovery. UV analysis of NTO established an isosbestic point based on varied pH at a detection wavelength of 341 nm. The two-stage soil extraction method is equally effective for traditional munition compounds, a potentially important point when examining soils exposed to both traditional and insensitive munitions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Medienpädagogische Aufgabenfelder hinsichtlich der Visualität im digitalen Zeitalter. Desiderate im Umgang mit visuellen Medienkulturen

Directory of Open Access Journals (Sweden)

Petra Missomelius

2017-04-01

Full Text Available Die bildungskulturell leitende Funktion des Buches diffundiert im digitalen Zeitalter mobiler und transversaler Systeme von Netzwerkmedien. Zudem sind soziokulturelle Lebenswelten wie Bildungsinstitutionen, Familie und Peers durch Heterogenität gekennzeichnet. Indem auch diese Teil des Geflechts medienkultureller Architekturen werden, geraten ehemals gültige Unterscheidungsparameter wie explizites und implizites, formelles und informelles Wissen ins Wanken. Grenzziehungen und konkurrierende Auffassungen gegenüber diesen, vormals als der Bildung entgegengesetzt wahrgenommenen, Bereichen erweisen sich nunmehr als problematisch. So spielt Visualität im Kontext multimodal zusammengesetzter Bildungsmaterialien eine zunehmende Rolle und wird als Möglichkeit des Umgangs mit Komplexität eingesetzt. Wenngleich somit die Zurückhaltung gegenüber (Bewegt-Bildmedien in der pädagogischen Praxis schwindet, so haben sich mit der Digitalisierung medienkulturell bedeutsame Felder eröffnet, welche erziehungswissenschaftlicher Beachtung bedürfen. Eine sich der Komplexität digitaler Medienkulturen stellende Medienpädagogik bringt mit sich, dass auch Funktion und Gebrauch visueller Medien im Kontext von Bildungsprozessen reflektiert stattfinden. Medienpädagogisch informiertes Agieren in visuellen Medienkulturen ist darüber hinaus heute gerade deshalb essentiell, da es sich bei digital generierter Visualität um eine neue Qualität im Unterschied zu traditionellen Bildmedien handelt, welche der Logik der Repräsentation entsprachen. Der Beitrag thematisiert Desiderate, die sich hinsichtlich des Visuellen datenbasierter Medien für die Medienpädagogik ergeben, und geht dabei auf kommunikative Bildlichkeit, auf paradigmatische mediale Formen und auf datengestützte Wissensgenerierung ein.

IMS Intra- and Inter Domain End-to-End Resilience Analysis

DEFF Research Database (Denmark)

Kamyod, Chayapol; Nielsen, Rasmus Hjorth; Prasad, Neeli R.

2013-01-01

This paper evaluated resilience of the reference IMS based network topology in operation through the keys reliability parameters via OPNET. The reliability behaviors of communication within similar and across registered home IMS domains were simulated and compared. Besides, the reliability effects...

EFEKTIVITAS MEDIA PEMBELAJARAN IM3 DITINJAU DARI MOTIVASI BELAJAR

Directory of Open Access Journals (Sweden)

J. Handhika

2012-10-01

Full Text Available Penelitian ini bertujuan untuk mengetahui perbedaan penggunaan media pembelajaran IM3 berbasis flash dan media MS. Power Point terhadap prestasi belajar IPA-Fisika. Hasil penelitian  menunjukkan bahwa siswa yang diajar menggunakan media IM3 berbasis flash memberikan rata-rata prestasi lebih baik dibandingkan dengan siswa yang diajar menggunakan power point. Siswa dengan motivasi belajar tinggi menghasilkan rata-rata prestasi lebih baik daripada siswa dengan motivasi belajar rendah, serta terdapat interaksi motivasi belajar dengan media pembelajaran terhadap prestasi belajar IPA-Fisika.   This study aims to determine differences in the use of flash-based IM3 learning media and MS media. Power Point to IPA-Physics learning achievement. Results showed that students who were taught using flash-based media IM3 gives an average performance better than students who were taught using the power point. Students with high motivation to learn the average yield better performance than students with low learning motivation, and there is interaction with the medium of learning motivation toward science learning achievement-Physics.

Ausländische Direktinvestitionen und Technologietransfer im angolanischen Energiesektor

Directory of Open Access Journals (Sweden)

2016-04-01

Full Text Available Dem Zusammenhang von ausländischen Direktinvestionen (Foreign Direct Investment, FDI und Technologietransfer wird sowohl in der Forschung als auch in der politischen Analyse große Bedeutung zugeschrieben. Zahlreiche Veröffentlichungen belegen, dass FDI den Transfer von und/oder den Zugang zu Technologien erleichtert. Allerdings gibt es zu wenige empirische Studien, die diesen Zusammenhang in Bezug auf die Wirtschaft afrikanischer Staaten untersuchen. Der Autor will diese Lücke zu einem kleinen Teil schließen, indem er die Bedeutung des Technologietransfers durch den Zufluss von FDI im Energiesektor Angolas ermittelt. Seine Analyse basiert auf qualitativer Forschung in Angola im Jahr 2014. Er zeigt auf, dass sich die Erzeugung von Energie(trägern und die Verteilungsinfrastruktur - maschinelle Ausrüstung und Qualifizierung - durch den Zufluss von FDI erheblich entwickeln konnte. Allerdings gebe es keinen Beleg dafür, dass dieser Zufluss die endogenen wissenschaftlichen und technologischen Forschungspotenziale im angolanischen Energiesektor gefördert hat. Der Autor empfiehlt politische Maßnahmen zur Förderung dieser Fähigkeiten, insbesondere im Bereich der Produktion.

Malignant eccrine paramar

International Nuclear Information System (INIS)

Al-Ahwal, Mahmoud S.; Zimmo, Sameer K; Sawan, Ali S.

2005-01-01

Benign eccrine poroma arises from the intraepidermal portion of the eccrine gland duct. Malignant transformation is rare and should be suspected when these lesions present with pain, bleeding or itching. We report a 44-year-old male patient who presented primarily with a lesion diagnostic of benign eccrine poroma of the right foot sole with no clear evidence of malignancy, which was incompletely excised, followed 5 months later by local recurrence, ulceration, occasional bleeding and right inguinal lymphadenopathy. Incomplete excision of the primary tumor as well as excision of a skin lesion on the right knee joint revealed malignant eccrine poroma with aggressive histology, lymphovascular and perineural invasion. Investigations revealed no evidence of distant metastasis. This tumor might be malignant at the first presentation, which was not confirmed histopathologically considering the short duration of only 5 months for malignant transformation. The patient received 3 cycles of Docetaxel Taxotere, Cisplatin combination chemotherapy with partial response. The management of metastatic malignant eccrine poroma is difficult. It has proven resistant to many chemotherapeutic agents and radiotherapy. (author)

ifo Konjunkturprognose 2015/2016: Deutsche Wirtschaft im Aufschwung

OpenAIRE

Wollmershäuser, Timo; Nierhaus, Wolfgang; Berg, Tim Oliver; Breuer, Christian; Garnitz, Johanna; Grimme, Christian; Henzel, Steffen; Hristov, Atanas; Hristov, Nikolay; Meister, Wolfgang; Schröter, Felix; Steiner, Andreas; Wieland, Elisabeth; Wohlrabe, Klaus; Wolf, Anna

2015-01-01

Die deutsche Wirtschaft befindet sich derzeit in einem kräftigen Aufschwung. Das reale Bruttoinlandsprodukt wird in diesem Jahr voraussichtlich um 1,9% expandieren und im kommenden Jahr um 1,8%. Der private Konsum bleibt die Stütze des Aufschwungs, da die Einkommensperspektiven der privaten Haushalte aufgrund der sich weiter verbessernden Arbeitsmarktlage gut sind. Allerdings entfallen allmählich die Kaufkraftgewinne durch den Ölpreisrückgang, so dass sich die Konsumdynamik im Prognosezeitrau...

Primary malignant melanoma

Directory of Open Access Journals (Sweden)

A. Ferhat Mısır

2016-04-01

Full Text Available Malignant melanomas (MM of the oral cavity are extremely rare, accounting for 0.2% to 8.0% of all malignant melanomas. Malignant melanomas is more frequently seen at the level of the hard palate and gingiva. Early diagnosis and treatment are important for reducing morbidity. Malignant melanoma cells stain positively with antibodies to human melanoma black 45, S-100 protein, and vimentin; therefore, immunohistochemistry can play an important role in evaluating the depth of invasion and the location of metastases. A 76-year-old man developed an oral malignant melanoma, which was originally diagnosed as a bluish reactive denture hyperplasia caused by an ill-fitting lower denture. The tumor was removed surgically, and histopathological examination revealed a nodular-type MM. There was no evidence of recurrence over a 4-year follow-up period.

Measuring cognitive change with ImPACT: the aggregate baseline approach.

Science.gov (United States)

Bruce, Jared M; Echemendia, Ruben J; Meeuwisse, Willem; Hutchison, Michael G; Aubry, Mark; Comper, Paul

2017-11-01

The Immediate Post-Concussion Assessment and Cognitive Test (ImPACT) is commonly used to assess baseline and post-injury cognition among athletes in North America. Despite this, several studies have questioned the reliability of ImPACT when given at intervals employed in clinical practice. Poor test-retest reliability reduces test sensitivity to cognitive decline, increasing the likelihood that concussed athletes will be returned to play prematurely. We recently showed that the reliability of ImPACT can be increased when using a new composite structure and the aggregate of two baselines to predict subsequent performance. The purpose of the present study was to confirm our previous findings and determine whether the addition of a third baseline would further increase the test-retest reliability of ImPACT. Data from 97 English speaking professional hockey players who had received at least 4 ImPACT baseline evaluations were extracted from a National Hockey League Concussion Program database. Linear regression was used to determine whether each of the first three testing sessions accounted for unique variance in the fourth testing session. Results confirmed that the aggregate baseline approach improves the psychometric properties of ImPACT, with most indices demonstrating adequate or better test-retest reliability for clinical use. The aggregate baseline approach provides a modest clinical benefit when recent baselines are available - and a more substantial benefit when compared to approaches that obtain baseline measures only once during the course of a multi-year playing career. Pending confirmation in diverse samples, neuropsychologists are encouraged to use the aggregate baseline approach to best quantify cognitive change following sports concussion.

ImSET: Impact of Sector Energy Technologies

Energy Technology Data Exchange (ETDEWEB)

Roop, Joseph M.; Scott, Michael J.; Schultz, Robert W.

2005-07-19

This version of the Impact of Sector Energy Technologies (ImSET) model represents the ''next generation'' of the previously developed Visual Basic model (ImBUILD 2.0) that was developed in 2003 to estimate the macroeconomic impacts of energy-efficient technology in buildings. More specifically, a special-purpose version of the 1997 benchmark national Input-Output (I-O) model was designed specifically to estimate the national employment and income effects of the deployment of Office of Energy Efficiency and Renewable Energy (EERE) -developed energy-saving technologies. In comparison with the previous versions of the model, this version allows for more complete and automated analysis of the essential features of energy efficiency investments in buildings, industry, transportation, and the electric power sectors. This version also incorporates improvements in the treatment of operations and maintenance costs, and improves the treatment of financing of investment options. ImSET is also easier to use than extant macroeconomic simulation models and incorporates information developed by each of the EERE offices as part of the requirements of the Government Performance and Results Act.

Solvation of UCl{sub 6}{sup 2-} anionic complex by MeBu{sub 3}N{sup +}, BuMe{sub 2}Im{sup +} and BuMeIm{sup +} cations

Energy Technology Data Exchange (ETDEWEB)

Bosse, Emilie; Den Auwer, Christophe; Berthon, Claude; Guilbaud, Philippe; Moisy, Philippe [CEA Marcoule, DRCP/SCPS, BP 17171, 30207 Bagnols sur Ceze Cedex (France); Grigoriev, Mikhail S. [A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, RAS, Leninskii Prosp. 31, 119991 Moscow (Russian Federation); Nikitenko, Serguei [CNAB, UMR 5084, CNRS - Universite de Bordeaux 1, BP 120 Le Haut Vigneau, 33175 Gradignan Cedex (France); Le Naour, Claire; Cannes, Celine [IPN, UMR 8608, CNRS, Universite Paris-Sud, 91406 Orsay (France)

2008-07-01

The complexes [MeBu{sub 3}N]{sub 2}[UCl{sub 6}] and [BuMe{sub 2}Im]{sub 2}[UCl{sub 6}] were characterized in the solid state and in solution of [MeBu{sub 3}N][Tf{sub 2}N], [BuMe{sub 2}Im][Tf{sub 2}N] and [BuMeIm][Tf{sub 2}N] room temperature ionic liquids using single-crystal XRD, EXAFS, electrochemistry, UV-visible absorption spectroscopy and NMR. In the solid and in solution, the existence of hydrogen bonding between the anionic UCl{sub 6}{sup 2-} complex and the ionic liquid cations were revealed by these techniques. The MeBu{sub 3}N{sup +} cation interacts with UCl{sub 6}{sup 2-} via the protons on the alpha carbon atoms of nitrogen. The protons of the imidazolium ring account for the interaction between the BuMe{sub 2}Im+ cation and the UCl{sub 6}{sup 2-} anion. For the BuMeIm{sup +} cation the major interaction was confirmed between the most acidic proton on C(2) and UCl{sub 6}{sup 2-}. The experimental results also show that the intensity of the interaction between the UCl{sub 6}{sup 2-} anion and the cation varies with the ionic liquid cation in the following order: MeBu{sub 3}N{sup +} {approx} BuMe{sub 2}Im{sup +} << BuMeIm{sup +}. (authors)

Elastolysen und Hauterkrankungen mit Verlust der elastischen Fasern.

Science.gov (United States)

Tronnier, Michael

2018-02-01

Die elastischen Fasern sind neben den kollagenen Fasern der wichtigste Bestandteil des Bindegewebsgerüstes der Haut. Eine Verminderung oder ein Verlust der elastischen Fasern ist bei einer Vielzahl von klinisch sich unterschiedlich präsentierenden Erkrankungen, hereditär oder erworben, beschrieben. Bei den Erkrankungen, die mit einer Entzündung einhergehen ist die Elastophagozytose ein wichtiges histologisches Merkmal. Die Therapie der Erkrankungen dieser Gruppe ist grundsätzlich schwierig. © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Handover Based IMS Registration Scheme for Next Generation Mobile Networks

Directory of Open Access Journals (Sweden)

Shireen Tahira

2017-01-01

Full Text Available Next generation mobile networks aim to provide faster speed and more capacity along with energy efficiency to support video streaming and massive data sharing in social and communication networks. In these networks, user equipment has to register with IP Multimedia Subsystem (IMS which promises quality of service to the mobile users that frequently move across different access networks. After each handover caused due to mobility, IMS provides IPSec Security Association establishment and authentication phases. The main issue is that unnecessary reregistration after every handover results in latency and communication overhead. To tackle these issues, this paper presents a lightweight Fast IMS Mobility (FIM registration scheme that avoids unnecessary conventional registration phases such as security associations, authentication, and authorization. FIM maintains a flag to avoid deregistration and sends a subsequent message to provide necessary parameters to IMS servers after mobility. It also handles the change of IP address for user equipment and transferring the security associations from old to new servers. We have validated the performance of FIM by developing a testbed consisting of IMS servers and user equipment. The experimental results demonstrate the performance supremacy of FIM. It reduces media disruption time, number of messages, and packet loss up to 67%, 100%, and 61%, respectively, as compared to preliminaries.

Regelungen im Verkehr mit Lebensmitteln und Bedarfsgegenständen in Deutschland

Science.gov (United States)

Thomas, Gundula; Freund, Astrid; Gründig, Friedrich

Im Zuge der Globalisierung von Produktion und Handel ändert sich auch der Charakter der Vorschriften im Lebensmittelrecht. Zunehmend treten internationale Rechtsbestimmungen, Abkommen, Standards und andere Normen an die Stelle nationaler Regelungen.

Robust stator resistance identification of an IM drive using model reference adaptive system

International Nuclear Information System (INIS)

Madadi Kojabadi, Hossein; Abarzadeh, Mostafa; Aghaei Farouji, Said

2013-01-01

Highlights: ► We estimate the stator resistance and rotor speed of the IM. ► We proposed a new quantity to estimate the speed and stator resistance of IM. ► The proposed algorithm is robust to rotor resistance variations. ► We estimate the IM speed and stator resistance simultaneously to avoid speed error. - Abstract: Model reference adaptive system (MRAS) based robust stator resistance estimator for sensorless induction motor (IM) drive is proposed. The MRAS is formed with a semi-active power quantity. The proposed identification method can be achieved with on-line tuning of the stator resistance with robustness against rotor resistance variations. Stable and efficient estimation of IM speed at low region will be guaranteed by simultaneous identification of IM speed and stator resistance. The stability of proposed stator resistance estimator is checked through Popov’s hyperstability theorem. Simulation and experimental results are given to highlight the feasibility, the simplicity, and the robustness of the proposed method.

Thermal Degradation Study of IM7/DMBZ-15 High Temperature Composite by TGA/FTIR

National Research Council Canada - National Science Library

Nadler, Melvin

2003-01-01

(U) High temperature graphite composites such as IM7/8552 epoxy, IM7/5250 BMI, and IM7/DMBZ-15 polyimide show blistering and/or "catastrophic" delamination when rapidly heated to temperatures above...

[Variation im heutigen Deutsch...] / Laura Tidrike

Index Scriptorium Estoniae

Tidrike, Laura

2008-01-01

Arvustus: Variation im heutigen Deutsch : Perspektiven für den Sprachunterricht / hrsg. v. Eva Neuland. Frankfurt am Main : Lang, 2006. (Sprache - Kommunikation - Kultur. Soziolinguistische Beiträge ; Vol. 4)

Global R&D through the Intelligent Manufacturing Systems (IMS) program

Science.gov (United States)

Huray, Paul G.

1997-01-01

The industry-led, international intelligent manufacturing systems (IMS) program provides a special vehicle for joint research and development between government, industry and academia in the United States, Canada, Japan, Australia, and Europe. Since its beginning in 1989, the IMS program has progressed through a feasibility phase which demonstrated that international legal barriers, trade issues, and intellectual property problems could be overcome. The program is constructed to provide higher quality design, customized products, shorter delivery cycles and lower costs. Interactions between partner companies have led to new business opportunities for mutual profit and some claim to have learned strategic information about their international competitors. The IMS program is growing through the participation of hundreds of corporate and university partners who share responsibilities in specific projects and jointly reap benefits for their manufacturing products and processes. The logic for choosing or not choosing the IMS mechanisms will be discussed and R and D projects will be identified.

Estudios por imágenes en reumatismo

Directory of Open Access Journals (Sweden)

Muñoz Ch. Sara, Dra.

2012-07-01

Los grandes avances tecnológicos de la última década han mejorado la calidad y cantidad de información que las distintas técnicas aportan, especialmente la RM; esto hace vislumbrar un cambio significativo en el diagnóstico por imágenes, ya que en el futuro no solo estará basado en los cambios morfológicos en órganos y tejidos; las imágenes obtenidas aportarán información bioquímica, molecular y fisiológica de los procesos patológicos facilitando su diagnóstico aun más precoz.

Malignant disease and dentistry.

Science.gov (United States)

Walton, Graham; Seymour, Robin A

2009-11-01

Reports of an ageing population, increasing incidence of malignancy and improved treatments mean that dentists may have an increasing number of patients with, or who have recovered from, a malignancy. Dental professionals are expected to have an understanding of this important disease group so that appropriate dental care can be provided safely. In this first of three articles, we shall describe the important epidemiological and clinical features of the commonest malignancies in the United Kingdom. Dentists should understand the clinical implications of a patient with, or recovering from, a malignancy. This article gives a summary of the relevant features of the commonest malignancies.

Using IMS VDEX in Agrega

Directory of Open Access Journals (Sweden)

Jose Manuel Canabal

2009-03-01

Full Text Available An essential element in a learning object repository is the meta-information associated with the resources housed by the repository, as this is what enables the objects to be retrieved. In many cases, the meta-information which is described consists of the classification of a resource in relation to a taxonomy or thesaurus. Agrega is a network of learning object repositories in which an LOM profile, called LOM-ES, has been used to label the objects. Part of the meta-information described corresponds to the classification of the object with respect to a group of taxonomies and a thesaurus, which have had to be described using the ims vdex standard to enable them to be managed from the federation nodes. This article describes the way in which ims vdex has been used in order to create this description and how these metadata instances are managed.

MRI, CT, and sonography in the preoperative evaluation of primary tumor extension in malignant pleural mesothelioma; MRT, CT und Sonographie in der praeoperativen Beurteilung der Primaertumorausdehnung beim malignen Pleuramesotheliom

Energy Technology Data Exchange (ETDEWEB)

Layer, G.; Steudel, A.; Schild, H.H. [Radiologische Universitaetsklinik Bonn (Germany); Schmitteckert, H.; Tuengerthal, S.; Schirren, J. [Thoraxklinik Heidelberg-Rohrbach (Germany); Kaick, G. van [Deutsches Krebsforschungszentrum Heidelberg (Germany). Schwerpunkt fuer Onkologische Diagnostik und Therapie

1999-04-01

Purpose: Evaluation of the diagnostic value of the imaging modalities computed tomography (CT), magnetic resonance imaging (MRI), and thoracic sonography in the preoperative staging of malignant pleural mesothelioma. Results: The accuracy rates for CT were 85%, 98%, 83%, 73%, 71%, and 83%. MRI had an accuracy of 71%, 92%, 71%, 83%, 71%, and 96%, the thoracic ultrasound examinations of 76%, 63%, 51%, 60%, 71% and 89%. Conclusions: According to these results CT remains the method of choice in the preoperative assessment of T-stage of malignant pleural mesothelioma. MRI is of nearly the same value, but is not a must. Sonography may be supplementary method for operation planning. (orig./AJ) [Deutsch] Ziel: Evaluation der diagnostischen Wertigkeit der Schnittbildverfahren MRT, CT und Sonographie in der praeoperativen Diagnostik des Pleuramesothelioms. Ergebisse: Die Treffsicherheiten betrugen fuer die genannten anatomischen Regionen im CT 85%, 98%, 83%, 73%, 71%, und 83%, im MRT 71%, 92%, 71%, 83%, 71% bzw. 96%, waehrend sich fuer die thorakale Ultraschalluntersuchung Treffsicherheiten von 76%, 63%, 51%, 60%, 71% und 89% errechneten. Schlussfolgerungen: Die CT bleibt damit das Verfahren erster Wahl in der praeoperativen Diagnostik des malignen Pleuramesothelioms. Eine unbedingte Forderung nach praeoperativer Durchfuehrung einer MRT-Untersuchung ergibt sich nach der vorliegenden Studie nicht. Die Sonographie des Thorax und oberen Abdomens liefert einen wichtigen ergaenzenden Beitrag bei der Planung der Operation des malignen Pleuramesothelioms. (orig./AJ)

İletişim Çalışmalarında Yeni Bir Mecra: Finansal İletişim

Directory of Open Access Journals (Sweden)

Gökhan Gökgöz

2013-09-01

Full Text Available 1970’li yıllar toplumsal ve politik tarih açısından önemli bir uğrağı temsil eder. Bu yılların başında yaşanan kriz, ekonominin işleyiş süreçlerini, devletin yapısını ve toplumsal alanın tasavvur edilme biçimini büyük ölçüde değiştirmiştir. Bu dönemde, finansal sermaye, kapitalizm içerisinde bir hegemonik lider olarak ön plana çıkmış; devlet, bir yandan üretimin çekirdeğinden uzak bir yerde konumlandırılırken diğer yandan paranın dolaşım kanallarının rehabilitasyonu işine odaklanmış; insana ilişkin değerler, kültürel mefhumlar ve toplumsal pratikler ise birer değişken olarak ekonomi-politikanın merkezine taşınmıştır. Kültür ile ekonomi arasındaki geleneksel ilişki bozulmuş; bir ekonomi-politikanın başarısı, toplumsal aktörlere temas etme kabiliyeti ile paralel hale gelmiştir. Finansallaşma sürecinde bu temas, iletişim politikaları vasıtasıyla sağlanır; ekonomi-politika ve bundan sorumlu merkezi kurumlarla toplumsal alan arasındaki bağ, iletişim stratejileri üzerinden kurulur; ekonomik alan ile kültürel alan arasındaki boşluk, iletişim kanalları içerisinden taşınan enformasyon marifetiyle doldurulur; insana ilişkin öngörülemezlikler, iletişim süreçleri vasıtasıyla öngörülebilir kılınır. Bu çalışmada, iletişim çalışmaları içerisinde yeni bir mecra olarak çağrılan “finansal iletişim”in farklı temas noktalarına işaret edilecek ve her bir uğrağın finansal iletişim alanına bağlandığı nokta, modeller üzerinden gösterilecektir. 

Ein Ausblick auf Supply-Chain-Management im Jahr 2016

DEFF Research Database (Denmark)

Wieland, Andreas

2016-01-01

Wie sieht Supply-Chain-Management im Jahr 2016 aus? Was erwartet uns? Vieles deutet darauf hin, dass SCM in Zukunft sogar noch mehr auf den Kunden gerichtet sein könnte als bisher.......Wie sieht Supply-Chain-Management im Jahr 2016 aus? Was erwartet uns? Vieles deutet darauf hin, dass SCM in Zukunft sogar noch mehr auf den Kunden gerichtet sein könnte als bisher....

Report on converging insert moulding with µ-IM

DEFF Research Database (Denmark)

Islam, Aminul

moulding with µ-IM  Task 5.2.1 and COTECH demonstrator: guide line for 5PRC production based on the concept of Task 5.2.1 Information and results provided by this deliverable will be directly used for one of the COTECH demonstrators production which will call for convergent insert moulding with µ......Task 5.2.1 deals with the technical feasibility of converging the state-of-the-art µ IM process with insert moulding to offer a wide range of multi-material µ components. The main objective of this deliverable is to summarize state-of-the-art information and to make the guideline needed...... for the convergence. In particular the following aspects are summed up in the deliverable:  Need for converging insert moulding with µ-IM  Objectives and expected outcome from task 5.2.1  State-of-the-art micro insert moulding and different scenario of micro insert moulding  Challenges ahead of converging insert...

A SURVEY ON INDIAN EXPERIENCE ON INTEGRATED MANAGEMENT STANDARDS (IMS

Directory of Open Access Journals (Sweden)

H. Khanna

2009-09-01

Full Text Available Adoption of management systems standards is a key issue in manufacturing industry in India. Following the global trend quality and environmental issues are gaining importance. However the number of ISO 14001 certified companies are much less in India as compared to ISO 9001. The integration of ISO 14001 with ISO 9001 may help companies to sustain competitive advantage and overcome disappointments with quality standards and in turn encourage companies to adopt good environmental practices. The aim of this research is to study the implementation of integrated management standards (IMS by the manufacturing organizations in India. The different aspects of integration and benefits of IMS implementation are analyzed. This r esearch is based on empirical study carried out in Indian manufacturing firms, involving the application of a questionnaire. This questionnaire was tested on 50 manufacturing companies in India. The study reveals that focus on stakeholders; top management commitment and training are critical success factors for implementation of IMS. The main benefits of integration are discussed. The small sample size is one of the major limitations of this study. The paper informs the managers in manufacturing organizations and practitioners of management system standards especially in developing countries about IMS and will enable them to adopt IMS in future so that those organizations may not implement multiple and overlapping MSS(Management System Standards.

Environmental trace analysis by means of supersensitive GC-IMS

International Nuclear Information System (INIS)

Leonhardt, J.W.

1997-01-01

The effective control of pollutants in ambient air requires their fast in situ identification and concentration determination of chemical compounds in the range of micrograms per m 3 . There are attempts to use conventional analytical techniques as portable GC and GC-MS. These systems are relatively expensive. A new supersensitive ion Mobility Sensor (IMS) was developed and checked by IUT Ltd, which meets the new demands. The use of tritium sources is an advantage in comparison with other IMS being equipped by nickel-63, the application of which is rather critical in respect of the radiation protection. On the other hand an integrated separation column allows to reduce interferences by matrix effects. The technical parameters of the IUT GC- IMS and some of its most important applications are briefly presented

Digital Medien im Naturwissenschaftlichen Unterricht

CERN Document Server

Meßinger-Koppelt, Jenny

2014-01-01

„Morgens, 8 Uhr: Kurz vor der Schultür werden noch die neuesten Posts auf Facebook geliked, ein Selfie in die Whats-App-Gruppe hochgeladen oder auf YouTube noch ein #LOL-Video gestreamed. Dann klingelt es und die Digital Natives greifen wieder zu Stift, Papier und werden frontal mit Fakten gefüttert“ (A. Spang). Für Schüler sind Internet, Smartphone und Tablet-PC heute selbstverständlicher Teil ihrer Lernwelt. Und auch die Alltags- und Berufswelt ist ohne Informationstechnologien nicht mehr vorstellbar. Doch was bedeutet das für den Schulunterricht, insbesondere für die techniknahen Naturwissenschaften? Wie gelingt im Schulalltag die Balance zwischen Kreidezeit und interaktivem Whiteboard nach mittlerweile 30 Jahren Erfahrung mit Schulcomputern? Der vorliegende Sammelband präsentiert zahlreiche Praxisbeispiele aus dem Schulalltag zum sinnvollen Einsatz digitaler Medien im Biologie-, Chemie- und Physik-Unterricht sowie den aktuellen Stand der fachdidaktischen Forschung. Zu Wort kommen Hochschullehr...

CORPORATIVE MOTIVES ON IMPLEMENTATION OF INTEGRATED MANAGEMENT SYSTEM (IMS

Directory of Open Access Journals (Sweden)

Dragan Rajkovic

2009-09-01

Full Text Available Integration of management systems for quality, environment, health and risk management as well as corporative social responsibilities is workable corporative approach to reduce costs, effective use of resources, higher motivation of employees and better fulfillment of requirements of social engagements and stakeholders. This paper presents contents of literature and review of a company motives on integrated management system (IMS implementation, namely factors affecting the IMS implementation.

A review of endocrine late effects in children after brain tumor therapy; Endokrinologische Funktionsstoerungen nach Hirntumortherapie im Kindesalter

Energy Technology Data Exchange (ETDEWEB)

Marx, M.; Langer, T.; Beck, J.D.; Doerr, H.G. [Erlangen-Nuernberg Univ., Erlangen (Germany). Kinderklinik mit Poliklinik

1999-07-01

Background: Advances in the therapy of malignant brain tumors in children have led to a significant improvement in survival rates over the last few decades. As a result, the recognition and treatment of late effects have become more important. In addition to secondary tumors and deficiencies in cognitive and intellectual skills, the resulting endocrine disturbances play an important role. Method: Own data and literature review. Results: Deviations from the normal growth hormone secretion are usually recognized first and are most common, and have already been observed after conventional whole brain irradiation with 18 G. With some delay, other hypothalamopituitary deficiencies may occur, including panhypopituitarism. Puberty may come too early or too late or may not appear at all. Girls in particular, frequently experience an early and rapid pubertal development after brain tumor therapy, which may lead to further reduction in height due to an accelerated bone maturation. Functional disturbances of the thyroid and adrenal glands due to hypothalamic or pituitary deficiency are less common, and usually seen only after a radiation dose of over 40 Gy. Conclusion: Survivors of childhood brain tumors must be considered as long-term survivors, in whom the first therapy-induced long-term side effects appear almost immediately after the end of therapy. Maximum quality of life for the individual patient can only be achieved by long-term care and close cooperation of specialists in the different medical disciplines involved. (orig.) [Deutsch] Hintergrund: Fortschritte in der Therapie maligner Hirntumoren im Kindesalter haben in den letzten Jahrzehnten zu einer deutlichen Verbesserung der Ueberlebensraten gefuehrt. Daher kommt dem Erkennen therapiebedingter Spaetfolgen zunehmend eine Bedeutung zu. Neben Zweittumoren, kognitiven und intellektuellen Einbussen spielen hormonelle Folgestoerungen eine bedeutende Rolle. Methode: Eigene Erfahrungen und Literaturrecherche. Ergebnisse

Interventional bronchoscopy in malignant central airway obstruction by extra-pulmonary malignancy.

Science.gov (United States)

Shin, Beomsu; Chang, Boksoon; Kim, Hojoong; Jeong, Byeong-Ho

2018-03-13

Interventional bronchoscopy is considered an effective treatment option for malignant central airway obstruction (MCAO). However, there are few reports of interventional bronchoscopy in patients with MCAOs due to extra-pulmonary malignancy. Therefore, the objective of this study was to investigate treatment outcomes and prognostic factors for bronchoscopic intervention in patients with MCAO due to extra-pulmonary malignancy. We retrospectively analyzed consecutive 98 patients with MCAO due to extra-pulmonary malignancy who underwent interventional bronchoscopy between 2004 and 2014 at Samsung Medical Center (Seoul, Korea). The most common primary site of malignancy was esophageal cancer (37.9%), followed by thyroid cancer (16.3%) and head & neck cancer (10.2%). Bronchoscopic interventions were usually performed using a combination of mechanical debulking (84.7%), stent insertion (70.4%), and laser cauterization (37.8%). Of 98 patients, 76 (77.6%) patients had MCAO due to progression of malignancy, and 42 (42.9%) patients had exhausted all other anti-cancer treatment at the time of bronchoscopic intervention. Technical success was achieved in 89.9% of patients, and acute complications and procedure-related deaths occurred in 20.4% and 3.1% of patients, respectively. Reduced survival was associated with MCAO due to cancer other than thyroid cancer or lymphoma, mixed lesions, and not receiving adjuvant treatment after bronchoscopic intervention. Bronchoscopic intervention could be a safe and effective procedure for MCAO due to end-stage extra-pulmonary malignancies. In addition, we identified possible prognostic factors for poor survival after intervention, which could guide clinicians select candidates that will benefit from bronchoscopic intervention.

Lipid peroxidation and antioxidants status in human malignant and non-malignant thyroid tumours.

Science.gov (United States)

Stanley, J A; Neelamohan, R; Suthagar, E; Vengatesh, G; Jayakumar, J; Chandrasekaran, M; Banu, S K; Aruldhas, M M

2016-06-01

Thyroid epithelial cells produce moderate amounts of reactive oxygen species that are physiologically required for thyroid hormone synthesis. Nevertheless, when they are produced in excessive amounts, they may become toxic. The present study is aimed to compare the lipid peroxidation (LPO), antioxidant enzymes - superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-protein thiols (reduced glutathione (GSH)) in human thyroid tissues with malignant and non-malignant disorders. The study used human thyroid tissues and blood samples from 157 women (147 diseased and 10 normal). Thyroid hormones, oxidative stress markers and antioxidants were estimated by standard methods. LPO significantly increased in most of the papillary thyroid carcinoma (PTC: 82.9%) and follicular thyroid adenoma (FTA: 72.9%) tissues, whilst in a majority of nodular goitre (69.2%) and Hashimoto's thyroiditis (HT: 73.7%) thyroid tissues, it remained unaltered. GSH increased in PTC (55.3%), remained unaltered in FTA (97.3%) and all other goiter samples studied. SOD increased in PTC (51.1%) and all other malignant thyroid tissues studied. CAT remained unaltered in PTC (95.7%), FTA (97.3%) and all other non-malignant samples (HT, MNG, TMNG) studied. GPx increased in PTC (63.8%), all other malignant thyroid tissues and remained unaltered in many of the FTA (91.9%) tissues and all other non-malignant samples (HT, MNG, TMNG) studied. In the case of non-malignant thyroid tumours, the oxidant-antioxidant balance was undisturbed, whilst in malignant tumours the balance was altered, and the change in r value observed in the LPO and SOD pairs between normal and PTC tissues and also in many pairs with multi-nodular goitre (MNG)/toxic MNG tissues may be used as a marker to differentiate/detect different malignant/non-malignant thyroid tumours. © The Author(s) 2015.

Detection of microbial volatile organic compounds (MVOC) by means of ion mobility spectroscopy (IMS); Detektion leicht fluechtiger organischer Verbindungen mikrobiellen Ursprungs (MVOC) mittels Ionenmobilitaetsspektrometrie (IMS)

Energy Technology Data Exchange (ETDEWEB)

Tiebe, Carlo

2010-07-01

Traces of microbial volatile organic compounds (MVOCs) can indicate the growth of moulds in the indoor air. The application of ion mobility spectrometry (IMS) is a very promising method for the detection of these MVOCs due to its high sensitivity. A mobile IMS device was tested to use this analytical-chemical method for in situ indoor air diagnostics. The first part of this work describes the test gas generation of 14 MVOCs in the laboratory. The test gases were produced by preparation of permeation procedures. Due to the MVOCs test gases IMS parameters like reduced mobility (K{sub 0}), relative drift time (t{sub rd}), the concentration dependency of MVOCs signals were determined and the limit of detection (LOD) was calculated. The LODs are in the range of 2 to 192 {mu}g m{sup -3} (1 to 51 ppb{sub V}). In the second part of this manuscript seven different mould species were cultivated on nutrient media and their MVOCs emissions were explored. It was found out, that the MVOCs emissions of moulds have a dependency of species and of their cultivation time. These results are confirmed by principal component analysis (PCA). The identification of these MVOCs was performed by test-related GC-MS analysis and approved these results. The MVOCs emissions were explored in the cultivation of mould mixtures on three different building materials. The IMS-results were interpreted chemo metrically by PCA. It was possible to find different emission patterns of cultivated moulds on building materials without an identification of the MVOCs inside the emission chamber. In 27 field trials of different indoor environments (rooms) the IMS was tested to detect MVOCs. In 59 % of the cases a positive correlation is determined between visible mould-infested rooms and the detected MVOCs by IMS. (orig.)

Environmental trace analysis by means of supersensitive GC-IMS

Energy Technology Data Exchange (ETDEWEB)

Leonhardt, J.W. [IUTLimited, Berlin, (Germany)

1997-10-01

The effective control of pollutants in ambient air requires their fast in situ identification and concentration determination of chemical compounds in the range of micrograms per m{sup 3}. There are attempts to use conventional analytical techniques as portable GC and GC-MS. These systems are relatively expensive. A new supersensitive ion Mobility Sensor (IMS) was developed and checked by IUT Ltd, which meets the new demands. The use of tritium sources is an advantage in comparison with other IMS being equipped by nickel-63, the application of which is rather critical in respect of the radiation protection. On the other hand an integrated separation column allows to reduce interferences by matrix effects. The technical parameters of the IUT GC- IMS and some of its most important applications are briefly presented 6 refs., 1 tab., 5 figs.

[Photoionization ion mobility spectrometry (UV-IMS) for the isomeric volatile organic compounds].

Science.gov (United States)

Li, Hu; Niu, Wen-qi; Wang, Hong-mei; Huang, Chao-qun; Jiang, Hai-he; Chu, Yan-nan

2012-01-01

The construction and performance study is reported for a newly developed ultraviolet photoionization ion mobility spectrometry (UV-IMS). In the present paper, an UV-IMS technique was firstly developed to detect eleven isomeric volatile organic compounds including the differences in the structure of carbon chain, the style of function group and the position of function group. Their reduced mobility values were determined and increased in this order: linears alcohols homemade UV-IMS was around ppb-ppm.

[Einheit und Vielfalt in der Rechtsgeschichte im Ostseeraum] / Marelle Leppik

Index Scriptorium Estoniae

Leppik, Marelle

2013-01-01

Arvustus: Einheit und Vielfalt in der Rechtsgeschichte im Ostseeraum. Unity and plurality in the legal history of the Baltic Sea area Sechster Rechtshistorikertag im Ostseeraum, 3.-5. Juni 2010 Tartu (Estland) / Riga (Lettland9. Hrsg. von Marju Luts-Sootak, Sanita Osipova und Frank L. Schäfer. (Rechtshistorische Reihe, Bd. 428.) Land. Frankfurt am Main u. a. 2012

Frauen im Netz weltweit – ausgegrenzt und mittendrin

Directory of Open Access Journals (Sweden)

Sigrid Peuker

2003-03-01

Full Text Available Mit dem Global Center for Women’s Studies and Politics (GLOW ist das Feministische Institut der Heinrich-Böll-Stiftung 1998 online gegangen. Mit diesem Schritt wurden Fragen nach den Möglichkeiten und Grenzen sowie nach den Gestaltungsräumen virtueller Kommunikation für Frauen zentral. Mit feminist_spaces. Frauen im Netz. Diskurse – Communities – Visionen, legt die Heinrich-Böll-Stiftung zusammen mit dem Feministischen Institut Antworten aus internationaler Perspektive vor. Das Buch geht auf die gleichnamige zweitätige Konferenz in Berlin im November 2001 zurück.

Malignant mesothelioma

Directory of Open Access Journals (Sweden)

Suzanne Alkul

2016-04-01

Full Text Available Seventy percent of patients with malignant mesothelioma have had exposure to asbestos fibers. Other patients without this exposure have had chronic pleural inflammation or received radiation to the thorax. Occasionally patients present with no obvious exposure history relevant to the development of malignant mesothelioma. This diagnosis needs to be in the differential diagnosis of all patients with unexplained pleural disease.

Malignant bone tumors

International Nuclear Information System (INIS)

Zedgenidze, G.A.; Kishkovskij, A.N.; Elashov, Yu.G.

1984-01-01

Clinicoroentgenologic semiotics of malignant bone tumors as well as metastatic bone tumors are presented. Diagnosis of malignant and metastatic bone tumors should be always complex, representing a result of cooperation of a physician, roentgenologist, pathoanatomist

Whole-body irradiation in case of malignant lymphomas of low malignancy

Energy Technology Data Exchange (ETDEWEB)

Labedzki, L; Schmidt, R E; Hartlapp, J H; Illiger, H J; Frommhold, H; Boldt, I

1982-04-01

27 consecutive patients with malignant lymphomas were submittet to whole-body irradiations with doses of 0.5 to 3 Gy. Among these patients ten had been treated before. There were two complete and 16 partial remissions. The condition of five patients could not be considerably improved. Four patients showed a tumor progression during the time of bone marrow depression. The remission period was 11.5 (3 to 22 +) months. The hematologic side effects were considerable; in ten cases, the whole-body irradiation could not be continued because of a thrombocytopenia or an aplastic syndrome. A remarkable fact was the appearance of symptoms similar to that of lupus erythematodes in two patients. An inefficacy of whole-body irradiation did not exclude a response to subsequent chemotherapy. Our own experiences allow to make the following conclusion: in most of all patients with malignant lymphomas of low malignancy a measurable tumor reduction is achieved by whole-body irradiation. Because of the hematologic side effects a whole-body irradiation should be applied only in cases of malignant lymphomas of low malignancy the slow growth of which is proved by observation and which have not been treated before. The thrombocyte numbers should be above 100 000/..mu..l before therapy. Otherwise, the whole-body irradiation has to be stopped before the intended effective dose is reached because of an inevitably developing thrombocytopenia. A whole-body irradiation in case of a malignant lymphoma of low grade malignancy necessitates strict follow-up examinations conducted at regular intervals for a period of at least six weeks after the irradiation. The whole-body irradiation should never be applied as ultima ratio.

Associations between United States Medical Licensing Examination (USMLE) and Internal Medicine In-Training Examination (IM-ITE) scores.

Science.gov (United States)

McDonald, Furman S; Zeger, Scott L; Kolars, Joseph C

2008-07-01

Little is known about the associations of previous standardized examination scores with scores on subsequent standardized examinations used to assess medical knowledge in internal medicine residencies. To examine associations of previous standardized test scores on subsequent standardized test scores. Retrospective cohort study. One hundred ninety-five internal medicine residents. Bivariate associations of United States Medical Licensing Examination (USMLE) Steps and Internal Medicine In-Training Examination (IM-ITE) scores were determined. Random effects analysis adjusting for repeated administrations of the IM-ITE and other variables known or hypothesized to affect IM-ITE score allowed for discrimination of associations of individual USMLE Step scores on IM-ITE scores. In bivariate associations, USMLE scores explained 17% to 27% of the variance in IME-ITE scores, and previous IM-ITE scores explained 66% of the variance in subsequent IM-ITE scores. Regression coefficients (95% CI) for adjusted associations of each USMLE Step with IM-ITE scores were USMLE-1 0.19 (0.12, 0.27), USMLE-2 0.23 (0.17, 0.30), and USMLE-3 0.19 (0.09, 0.29). No single USMLE Step is more strongly associated with IM-ITE scores than the others. Because previous IM-ITE scores are strongly associated with subsequent IM-ITE scores, appropriate modeling, such as random effects methods, should be used to account for previous IM-ITE administrations in studies for which IM-ITE score is an outcome.

Wir und die Anderen: Gruppenbezogene Menschenfeindlichkeit im Sport in Sachsen

OpenAIRE

Delto, Hannes; Tzschoppe, Petra

2015-01-01

Mit der Querschnittsstudie "Wir und die Anderen – Gruppenbezogene Menschenfeindlichkeit im organisierten Sport in Sachsen" wurde erstmals das Syndrom Gruppenbezogener Menschenfeindlichkeit im organisierten Sport untersucht. Das Konzept der Gruppenbezogenen Menschenfeindlichkeit – ausgehend von einer Ideologie der Ungleichwertigkeit – wurde von Prof. Wilhelm Heitmeyer (Universität Bielefeld) entwickelt. Die Ergebnisse ermöglichen explizite Aussagen über Ausmaß und Ursachen Gruppenbezogener Men...

Information management system study results. Volume 1: IMS study results

Science.gov (United States)

1971-01-01

The information management system (IMS) special emphasis task was performed as an adjunct to the modular space station study, with the objective of providing extended depth of analysis and design in selected key areas of the information management system. Specific objectives included: (1) in-depth studies of IMS requirements and design approaches; (2) design and fabricate breadboard hardware for demonstration and verification of design concepts; (3) provide a technological base to identify potential design problems and influence long range planning (4) develop hardware and techniques to permit long duration, low cost, manned space operations; (5) support SR&T areas where techniques or equipment are considered inadequate; and (6) permit an overall understanding of the IMS as an integrated component of the space station.

Grand Prix Eurovision: Eine Fankultur im Medienzeitalter

Directory of Open Access Journals (Sweden)

Heinz Moser

2017-06-01

Full Text Available Der Grand Prix Eurovision ist seit Jahrzehnten eine der bekanntesten Unterhaltungssendungen im europäischen Raum. Dennoch erregte es Verwunderung, wenn der Schreibende Bekannten darüber berichtete, daß dies ein Forschungsgegenstand sei. Wurde von Interviews mit Grand Prix-Fans erzählt, so fielen schnell Aussagen wie: „Wie kann man sich nur für so etwas Abseitiges und Triviales wie den Grand Prix interessieren“. Dennoch bin ich der Meinung, daß Fankulturen für die entstehende Mediengesellschaft ein nicht unwichtiges Forschungsthema darstellen. Zwar geht es nicht um eine medienpädagogische Fragestellung im engeren Sinne; die Fans des Grand Prix Eurovision sind dem Jugendalter längst entwachsen. Dennoch handelt es sich bei Fangemeinschaften um Phänomene, die im Rahmen von Jugend- und Kinderkulturen von besonderer Relevanz sind. So meint Winter (1997, daß jugendliche Fanwelten eine bedeutende Rolle als Kristallisationspunkte kultureller Differenzierung spielen: ,Die Zugehörigkeit zu einer Fan weit ist Teil der jugendlichen Lebensbewältigung in der Postmoderne, denn in der Gemeinschaft der Fans können Jugendliche emotionale Allianzen eingehen, außeralltäglichen Beschäftigungen nachgehen, expressive Identitätsmuster gemeinschaftlich realisieren und sich mit ihrer Lebenssituation als Heranwachsende auseinandersetzen“ (Winter 1997, S. 51f..

Neuroleptic Malignant Syndrome

Science.gov (United States)

... such as neuroleptic malignant syndrome. Much of this research focuses on finding ways to prevent and treat the disorder. Show More Show Less Search Disorders SEARCH SEARCH Definition Treatment Prognosis Clinical Trials Organizations Publications Definition Neuroleptic malignant syndrome is ...

Management of malignant pleural effusions.

LENUS (Irish Health Repository)

Uzbeck, Mateen H

2010-06-01

Malignant pleural effusions are a common clinical problem in patients with primary thoracic malignancy and metastatic malignancy to the thorax. Symptoms can be debilitating and can impair tolerance of anticancer therapy. This article presents a comprehensive review of pharmaceutical and nonpharmaceutical approaches to the management of malignant pleural effusion, and a novel algorithm for management based on patients\\' performance status.

Down-conversion IM-DD RF photonic link utilizing MQW MZ modulator.

Science.gov (United States)

Xu, Longtao; Jin, Shilei; Li, Yifei

2016-04-18

We present the first down-conversion intensity modulated-direct detection (IM-DD) RF photonic link that achieves frequency down-conversion using the nonlinear optical phase modulation inside a Mach-Zehnder (MZ) modulator. The nonlinear phase modulation is very sensitive and it can enable high RF-to-IF conversion efficiency. Furthermore, the link linearity is enhanced by canceling the nonlinear distortions from the nonlinear phase modulation and the MZ interferometer. Proof-of-concept measurement was performed. The down-conversion IM-DD link demonstrated 28dB improvement in distortion levels over that of a conventional IM-DD link using a LiNbO3 MZ modulator.

Results from an Interval Management (IM) Flight Test and Its Potential Benefit to Air Traffic Management Operations

Science.gov (United States)

Baxley, Brian; Swieringa, Kurt; Berckefeldt, Rick; Boyle, Dan

2017-01-01

NASA's first Air Traffic Management Technology Demonstration (ATD-1) subproject successfully completed a 19-day flight test of an Interval Management (IM) avionics prototype. The prototype was built based on IM standards, integrated into two test aircraft, and then flown in real-world conditions to determine if the goals of improving aircraft efficiency and airport throughput during high-density arrival operations could be met. The ATD-1 concept of operation integrates advanced arrival scheduling, controller decision support tools, and the IM avionics to enable multiple time-based arrival streams into a high-density terminal airspace. IM contributes by calculating airspeeds that enable an aircraft to achieve a spacing interval behind the preceding aircraft. The IM avionics uses its data (route of flight, position, etc.) and Automatic Dependent Surveillance-Broadcast (ADS-B) state data from the Target aircraft to calculate this airspeed. The flight test demonstrated that the IM avionics prototype met the spacing accuracy design goal for three of the four IM operation types tested. The primary issue requiring attention for future IM work is the high rate of IM speed commands and speed reversals. In total, during this flight test, the IM avionics prototype showed significant promise in contributing to the goals of improving aircraft efficiency and airport throughput.

A critical analysis of Sorrell v. IMS Health, Inc.: Pandora's box at best.

Science.gov (United States)

Bibet-Kalinyak, Isabelle

2012-01-01

Sorrell v. IMS Health, Inc. ("IMS Health"), a remarkable health care case with resounding First Amendment and economic repercussions, features the clashing interests of the State of Vermont and aggressive free market players from the pharmaceutical and data mining industries in a constitutional battle over Free Speech. In 2007, Vermont enacted Act 80, The Confidentiality of Prescription Information Act, prohibiting the sale, disclosure, and use of pharmacy records. Together with two other data miners and PhRMA, an association of brand-name drug manufacturers, IMS Health successfully challenged the constitutionality of Act 80 on First Amendment grounds. This article examines the legal arguments of IMS Health and Act 80 and analyzes why IMS Health stands out for potentially challenging the traditional doctrine of commercial speech and the resulting legal implications. After reviewing the Supreme Court's reasoning, the article concludes that, although the Supreme Court reached the appropriate outcome, it did so by unjustifiably departing from the established legal doctrine of commercial speech and the American tradition of consumer protection. At best, IMS Health's reasoning opens a legal Pandora's Box potentially leading to an onset of new commercial speech challenges; at worst, it manufactured a Trojan Horse aimed at eroding the traditional regulatory safeguards that maintain a balance between the needs of consumers and corporations alike.

Innovative Techniken und Algorithmen im Bereich Computational-Finance und Risikomanagement

OpenAIRE

Liang, Qian

2012-01-01

Diese Dissertation besteht aus zwei aktuellen Themen im Bereich Finanzmathematik, die voneinander unabhängig sind. Beim ersten Thema, "Flexible Algorithmen zur Bewertung komplexer Optionen mit mehreren Eigenschaften mittels der funktionalen Programmiersprache Haskell", handelt es sich um ein interdisziplinäres Projekt, in dem eine wissenschaftliche Brücke zwischen der Optionsbewertung und der funktionalen Programmierung geschlagen wurde. Im diesem Projekt wurde eine funktionale Biblio...

Die Raumdarstellung im erzählenden Werk um 1900

OpenAIRE

Lu, Xiaoli

2011-01-01

In der Literatur existiert eine eigene Welt, die mit Raum und Zeit verbunden ist. Im 19. Jahrhundert gewinnen beide, Raum und Zeit, an Bedeutung als bewusst eingesetzte Gestaltungselemente. Es bilden sich zwei Grundrichtungen heraus, eine mit dem Erzählgeschehen verknüpfte Semantisierung in der Klassik und in der Romantik und eine betonte Fixierung des Geschehens in der realen Welt durch genaue Zeit- und Ortsangaben im Realismus. Die Semantisierung von Raum und Zeit führt zu einer Bedeutungss...

[Das Bild und die Wahrnehmung der Stadt und der städtischen Gesellschaft im Hanseraum im Mittelalter und in der frühen Neuzeit] / Juhan Kreem

Index Scriptorium Estoniae

Kreem, Juhan

2009-01-01

Arvustus: Das Bild und die Wahrnehmung der Stadt und der städtischen Gesellschaft im Hanseraum im Mittelalter und in der frühen Neuzeit. hrsg. v. Roman Czaja. Torun, 2004. Torunis 2002. aastal toimunud konverentsi materjalid. Projekti "Pilt ja linn" raames ilmunud publikatsioonide loendit saab näha aadressil http://www.historiaurbium.org/english/attivita_images_en.html.

IMS Mitigation Target Areas - 2010 [ds673

Data.gov (United States)

California Natural Resource Agency — Mitigation Target Areas (MTA) were developed by the California Department of Fish and Game for the Interim Mitigation Strategy (IMS). The MTAs are an identification...

Mucorales-Specific T Cells in Patients with Hematologic Malignancies

OpenAIRE

Potenza, L; Vallerini, D; Barozzi, P; Riva, G; Gilioli, A; Forghieri, F; Candoni, A; Cesaro, S; Quadrelli, C; Maertens, J; Rossi, G; Morselli, M; Codeluppi, M; Mussini, C; Colaci, E

2016-01-01

Background Invasive mucormycosis (IM) is an emerging life-threatening fungal infection. It is difficult to obtain a definite diagnosis and to initiate timely intervention. Mucorales-specific T cells occur during the course of IM and are involved in the clearance of the infection. We have evaluated the feasibility of detecting Mucorales-specific T cells in hematological patients at risk for IM, and have correlated the detection of such cells with the clinical conditions of the patients. Method...

Hinderniserkennung und -verfolgung mit einer PMD-kamera im automobil

Science.gov (United States)

Schamm, Thomas; Vacek, Stefan; Natroshvilli, Koba; Marius Zöllner, J.; Dillmann, Rüdiger

Die Detektion von Hindernissen vor dem Automobil ist eine Hauptanforderung an moderne Fahrerassistenzsysteme (FAS). In dieser Arbeit wird ein System vorgestellt, das mit Hilfe einer PMDKamera (Photomischdetektor) Hindernisse auf der Fahrspur erkennt und deren relevante Parameter bestimmt. Durch die PMD-Kamera werden zunächst 3D-Tiefenbilder der Fahrzeugumwelt generiert. Nach einem initialen Filterprozess werden im Tiefenbild mit Hilfe eines Bereichswachstumsverfahrens Hindernisse gesucht. Zur Stabilisierung des Verfahrens und zur Parameterberechnung wird ein Kaiman Filter eingesetzt. Das Ergebnis ist eine Liste aller Hindernisse im Fahrbereich des Automobils.

[Christian Westerhoff. Zwangsarbeit im Ersten Weltkrieg. Deutsche Arbeitskräftepolitik im besetzten Polen und Litauen 1914-1918, Tilman Plath.Zwischen Schonung und Menschenjagden. Die Arbeitseinsatzpolitik in den baltischen Generalbezirken des Reich

Index Scriptorium Estoniae

Hiio, Toomas, 1965-

2014-01-01

Arvustus: Westerhoff, Christian. Zwangsarbeit im Ersten Weltkrieg. Deutsche Arbeitskräftepolitik im besetzten Polen und Litauen 1914-1918 (Studien zur historischen Migrationsforschung, 25). Verlag Ferdinand Schöningh. Padeborn 2011

MR imaging in gynecology and obstetrics; MR-Tomographie in Gynaekologie und Geburtshilfe

Energy Technology Data Exchange (ETDEWEB)

Bauer, M.; Tontsch, P.; Schulz-Wendtland, R. (eds.)

2000-07-01

The toolbook covers the full range of indications for MRI in obstetrics and gynecology. It is the joint work of radiologists and obstetrician-gynecologists and supplies state-of-the-art information needed by doctors in the private practice or a hospital department. Examples from the Table of Contents: Physical principles of MRI, applications and performance aspects. Systematic presentation of diagnostic findings for comparative analysis and assessment. Biological effects and risks. Benign and malignant neoplasms of the mammary glands and the female genital organs. MRI for prenatal care and diagnostic evaluation. New method: MR spectroscopy. (orig./CB) [German] Das Lehrbuch deckt alle Indikationen der MRT in Gynaekologie und Geburtshilfe ab. Es wurde von Radiologen und Frauenaerzten gemeinsam verfasst und ist daher praxisgerecht. Aus dem Inhalt: Physikalische Grundlagen und Durchfuehrung der MRT und Systematik fuer die Beurteilung der MRT-Befunde. Biologische Wirkungen und Risiken, benigne und maligne Erkrankungen der Brustdruese und der weiblichen Genitalorgane. MRT in der Schwangerschaft. Neue Methode: MR-Spektroskopie. (orig./AJ)

Primary ovarian malignant melanoma

Directory of Open Access Journals (Sweden)

Kostov Miloš

2010-01-01

Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

Toward an Intelligent Ion Mobility Spectrometer (IMS)

International Nuclear Information System (INIS)

McJunkin, Timothy R.; Scott, Jill R.; Miller, Carla J.

2003-01-01

The ultimate goal is to design and build a very smart ion mobility spectrometer (IMS) that can operate autonomously. To accomplish this, software capable of interpreting spectra so that it can be used in control loops for data interpretation as well as adjusting instrument parameters is being developed. Fuzzy logic and fuzzy numbers are used in this IMS spectra classification scheme. Fuzzy logic provides a straight forward method for developing a classification/detection system, whenever rules for classifying the spectra can be described linguistically. Instead of using 'max' and 'min' values, the product of the truth values is used to determine class membership. Using the product allows rule-bases that utilize the AND function to allow each condition to discount truth value in determining membership, while rule-bases with an OR function are allowed to accumulate membership. Fuzzy numbers allow encapsulation of the uncertainties due to ion mobility peak widths as well as measured instrumental parameters, such as pressure and temperature. Associating a peak with a value of uncertainty, in addition to making adjustments to the mobility calculation based on variations in measured parameters, enables unexpected shifts to be more reliably detected and accounted for; thereby, reducing the opportunity for 'false negative' results. The measure of uncertainty is anticipated to serve the additional purpose of diagnosing the operational conditions of the IMS instrument.

Improved detection of Mycobacterium bovis infection in bovine lymph node tissue using immunomagnetic separation (IMS-based methods.

Directory of Open Access Journals (Sweden)

Linda D Stewart

Full Text Available Immunomagnetic separation (IMS can selectively isolate and concentrate Mycobacterium bovis cells from lymph node tissue to facilitate subsequent detection by PCR (IMS-PCR or culture (IMS-MGIT. This study describes application of these novel IMS-based methods to test for M. bovis in a survey of 280 bovine lymph nodes (206 visibly lesioned (VL, 74 non-visibly lesioned (NVL collected at slaughter as part of the Northern Ireland bovine TB eradication programme. Their performance was evaluated relative to culture. Overall, 174 (62.1% lymph node samples tested positive by culture, 162 (57.8% by IMS-PCR (targeting IS6110, and 191 (68.2% by IMS-MGIT culture. Twelve (6.9% of the 174 culture positive lymph node samples were not detected by either of the IMS-based methods. However, an additional 79 M. bovis positive lymph node samples (27 (13.1% VL and 52 (70.3% NVL were detected by the IMS-based methods and not by culture. When low numbers of viable M. bovis are present in lymph nodes (e.g. in NVLs of skin test reactor cattle decontamination prior to culture may adversely affect viability, leading to false negative culture results. In contrast, IMS specifically captures whole M. bovis cells (live, dead or potentially dormant which are not subject to any deleterious treatment before detection by PCR or MGIT culture. During this study only 2.7% of NVL lymph nodes tested culture positive, whereas 70.3% of the same samples tested M. bovis positive by the IMS-based tests. Results clearly demonstrate that not only are the IMS-based methods more rapid but they have greater detection sensitivity than the culture approach currently used for the detection of M. bovis infection in cattle. Adoption of the IMS-based methods for lymph node testing would have the potential to improve M. bovis detection in clinical samples.

Die emotionale Dimension während der Sprechproduktion im Fremdsprachenlernprozess

Directory of Open Access Journals (Sweden)

Bahar İŞİGÜZEL

2017-12-01

Full Text Available Die Gefühle bzw. Emotionen der Lernenden beim Fremdsprachenlehr- und Lernprozess spielen eine wichtige Rolle. Mit der Verknüpfung der Emotion und Kognition beim Lernprozess, haben die positiven Gefühle eine große Bedeutung für den Lernerfolg. Als eine produktive Fertigkeit hat das Sprechen eine wesentlich intensive Beziehung mit den Emotionen, weil es in der realen Zeit fließend laufen muss. Der Lernende soll bei der Sprechproduktion spontan die richtigen Wörter auf die richtige Art und Weise anwenden und sie auch noch verständlich aussprechen. Leider erreicht die Sprechfertigkeit meistens eine niedrigere Niveaustufe als die anderen drei (Schreiben, Lesen und Hören Fertigkeiten im Fremdsprachenunterrichtprozess. Diese qualitative Untersuchung konzentriert sich auf die Daten (Tonaufnahme, die anhand eines Interviews während einer Sprechproduktionsübung im universitären Fremdsprachenunterricht gesammelt wurden. Um die emotionale Dimension der Lernenden während der Sprechproduktion zu identifizieren, wurden im Einzelinterview die Frage „Wie fühlst du dich während du eine Fremdsprache (Englisch sprichst?“ gestellt. Die Teilnehmer dieser Untersuchung waren 29 Studenten, die im WS 2016 - 2017 an Universität Nevşehir Hacı Bektaş Veli (Türkei immatrikuliert waren. Die Auswertung des Interviews folgte mit einer Transkription und einer Interpretation der Tonaufnahmen. Die Meinungen zu der emotionalen Dimension während der Sprechproduktion der Studenten wurden kategorisiert. Die Resultate dieser qualitativen Untersuchung zeigen, dass die emotionale Dimension der Lernenden im universitären Kontext sich in drei Kategorien (positiv, negativ und frühere Ausbildung verteilen.

The IMS Software Integration Platform

Science.gov (United States)

1993-04-12

products to incorporate all data shared by the IMS applications. Some entities (time-series, images, a algorithm -specific parameters) must be managed...dbwhoanii, dbcancel Transaction Management: dbcommit, dbrollback Key Counter Assignment: dbgetcounter String Handling: cstr ~to~pad, pad-to- cstr Error...increment *value; String Maniputation: int cstr topad (array, string, arraylength) char *array, *string; int arrayjlength; int pad tocstr (string

Biomechanisch-kinemetrische Bewegungsanalyse und Ansätze zur Bewegungssteuerung für ein Training im Wellenreiten

OpenAIRE

Matschkur, Tina

2008-01-01

Neben der biomechanisch-kinemetrischen Bewegungsanalyse einzelner ausgewählter Techniken im Wellenreiten beschäftigt sich diese Dissertation auch ansatzweise im Rahmen einer elektromyographischen Fallstudie mit der muskulären Koordination bei der Bewegungsausführung im Surfen, um daraus Schlussfolgerungen für das Training im Wellenreiten treffen zu können. Ein geschichtlicher und wissenschaftlicher Überblick über das Wellenreiten leitet das Thema ein und macht somit auf die besondere Ausgangs...

Eisengehalt von Fleisch - Ermittlung des Eisengehalts im Fleisch verschiedener Tierarten

OpenAIRE

Westphal, Karsten; Klose, Ralf; Golze, Manfred

2009-01-01

Der Bericht beinhaltet Ergebnisse von Fleischuntersuchungen auf den Eisengehalt. Untersucht wurden 308 Schweinefleischproben und etwa 300 Fleischproben der Tierarten Rind, Bison, Auerochse, Büffel, Schaf, Ziege, Kaninchen, Wildschwein, Rehwild, Rotwild und Fasan. Die sächsischen Ergebnisse bestätigen Untersuchungen anderer Bundesländer und belegen den starken Rückgang des Eisengehaltes im Schweinefleisch. Er lag im Mittel bei 4,1 mg/kg Frischmasse (FM). Vor 30 Jahren lag der Eisengehalt...

Quad-Polarization Transmission for High-Capacity IM/DD Links

DEFF Research Database (Denmark)

Estaran Tolosa, Jose Manuel; Castaneda, Mario A. Usuga; Porto da Silva, Edson

2014-01-01

We report the first experimental demonstration of IM/DD links usi ng four states of polarization. Fiber - Induced polarization rotation is compensated with a simple tracking algorithm operating on the Stokes space. The principle is prove n at 128 Gb/s over 2 - km SSMF......We report the first experimental demonstration of IM/DD links usi ng four states of polarization. Fiber - Induced polarization rotation is compensated with a simple tracking algorithm operating on the Stokes space. The principle is prove n at 128 Gb/s over 2 - km SSMF...

Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective review

International Nuclear Information System (INIS)

Chawla, Soni C.; Federman, Noah; Zhang, Di; Nagata, Kristen; Nuthakki, Soujanya; McNitt-Gray, Michael; Boechat, M.I.

2010-01-01

The increasing use of serial PET/CT scans in the management of pediatric malignancies raises the important consideration of radiation exposure in children. To estimate the cumulative radiation dose from PET/CT studies to children with malignancy and to compare with the data in literature. Two hundred forty-eight clinical PET/CT studies performed on 78 patients (50 boys/28 girls, 1.3 to 18 years old from December 2002 to October 2007) were retrospectively reviewed under IRB approval. The whole-body effective dose (ED) estimates for each child were obtained by estimating the effective dose from each PET/CT exam performed using the ImPACT Patient Dosimetry Calculator for CT and OLINDA for PET. The average number of PET/CT studies was 3.2 per child (range: 1 to 14 studies). The average ED of an individual CT study was 20.3 mSv (range: 2.7 to 54.2), of PET study was 4.6 mSv (range: 0.4 to 7.7) and of PET/CT study was 24.8 mSv (range: 6.2 to 60.7). The average cumulative radiation dose per patient from CT studies was 64.4 mSv (range: 2.7 to 326), from PET studies was 14.5 mSv (range: 2.8 to 73) and from PET/CT studies was 78.9 mSv (range: 6.2 to 399). The radiation exposure from serial PET/CT studies performed in pediatric malignancies was considerable; however, lower doses can be used for both PET and CT studies. The ALARA principle must be applied without sacrificing diagnostic information. (orig.)

Early recognition of lung cancer in workers occupationally exposed to asbestos; Frueherkennung von Lungenkrebs bei asbestexponierten Arbeitnehmern

Energy Technology Data Exchange (ETDEWEB)

Hofmann-Preiss, K. [BDT MVZ Erlangen, Erlangen (Germany); Rehbock, B. [Praxis fuer Diagnostische Radiologie mit pneumologischem Schwerpunkt, Berlin (Germany)

2016-09-15

Despite the fact that working with asbestos and placing it on the market have been banned in Germany since 1993 according to the Ordinance on Hazardous Substances, asbestos-related diseases of the lungs and pleura are still the leading cause of death in occupational diseases. The maximum industrial usage of asbestos was reached in former West Germany in the late 1970s and in former East Germany the late 1980s. Occupational diseases, mainly mesotheliomas and lung cancer emerging now are thus caused by asbestos exposure which occurred 30-40 years earlier. It is known that the combination of smoking and asbestos exposure results in a superadditive increase in the risk to develop lung cancer. No suitable screening methods for early detection of malignant mesothelioma are currently available and the therapeutic options are still very limited; however, the national lung screening trial (NLST) has shown for the first time that by employing low-dose computed tomography (LDCT) in heavy smokers, lung cancer mortality can be significantly reduced. According to current knowledge the resulting survival benefits far outweigh the potential risks involved in the diagnostic work-up of suspicious lesions. These results in association with the recommendations of international medical societies and organizations were pivotal as the German statutory accident insurance (DGUV) decided to provide LDCT as a special occupational medical examination for workers previously exposed to asbestos and with a particularly high risk for developing lung cancer. (orig.) [German] Asbestbedingte Erkrankungen von Lunge und Pleura sind in Deutschland noch immer die haeufigsten zum Tode fuehrenden Berufskrankheiten, obwohl die Verarbeitung und das Inverkehrbringen von Asbest gemaess der Gefahrstoffverordnung seit 1993 verboten sind. Das Maximum des Rohasbestverbrauchs in den alten Bundeslaendern war Ende der 70er, in den neuen Bundeslaendern Ende der 80er Jahre erreicht. Heute neu diagnostizierte

Radiologic evaluation of malignant histiocytoma

International Nuclear Information System (INIS)

Park, Ki Soon; Lee, Sun Wha; Yoon, Yup; Sung, Dong Wook; Ahn, Chi Yul

1987-01-01

Malignant fibrous histiocytoma is a new malignant tumor entity of histiocytic origin which arises as a primary tumor of the bone as well as the soft tissue. Radiologic features of 12 cases of pathologically proven intra-and extraosseous malignant fibrous histiocytoma were analyzed. The results were as follows : 1. Seven cases were of soft tissue origin and 5 cases were of primary bone origin. 2. Seven were male and 5 were female: Eight cases were beyond 5th decades. 3. The clinical presentations of malignant fibrous histiocytoma of the soft tissue origin were a mass with rapid growth or high rate of local recurrence. The roentgen evidence of soft tissue density mass was demonstrated in 7 cases and scintigraphic evidence of cortical invasion was suggested in 2 cases. 4. Malignant fibrous histiocytoma arising from bones had ill defined moth-eaten osteolytic lesion with cortical destruction, periosteal reaction and soft tissue extension. 5. Among 12 cases, there were 2 cases of pulmonary metastases and 2 cases of osseous metastases. 6. In the presence of soft tissue mass with locally aggressive behavior and/or nonspecific roentgen features of malignant bone tumor, one should consider the possibility of malignant fibrous histiocytoma

Skin changes in internal malignancy

Directory of Open Access Journals (Sweden)

Rajagopal Ravi

2004-07-01

Full Text Available BACKGROUND: Internal malignancies are accompanied by various skin changes which may be specific infiltrates or non-specific changes. This study is aimed at determining the frequency of such changes in malignant disease treatment center attendees in India. METHODS: A study of 300 confirmed cases of internal malignancy at a malignant disease treatment center was undertaken to evaluate these skin changes. Specific infiltrates were confirmed by histopathology. Statistical methods were employed to calculate significance in non-specific lesions by comparing with 300 controls not suffering from internal malignancy. RESULTS: Skin changes were present in 82 (27.3%. Cutaneous metastases were found in 19 (6.3%; non-contiguous in 5 (1.6%; contiguous in 14 (4.3%. Non-specific skin lesions numbered 74 (11.6% in 52 patients. Statistically significant non-specific skin changes were acquired ichthyosis, herpes zoster and generalized pruritus. CONCLUSION: Metastases usually occurred late in internal malignancy (17, 5.6% except in a case each of histiocytic lymphoma and non-Hodgkin′s lymphoma (2, 0.7% where the lesions preceded malignancy by 3 months and 1 month respectively. Contiguous nodules were a marker of relapse after surgery in 3 (1%.

Mykotische Infektionen des Penis

Directory of Open Access Journals (Sweden)

Mayser P

1999-01-01

Full Text Available Die häufigste mykotische Infektion des Penis stellt die Balanitis/Balonoposthitis durch Candida albicans dar. Sie weist eine steigende Inzidenz auf und scheint vornehmlich durch Genitalverkehr übertragen zu werden. Penile Infektionen durch Dermatophyten sind sehr selten, obwohl die Tinea inguinalis zu den häufigeren Erkrankungen zählt. Eine Mitbeteiligung des Penis im Rahmen von Systemmykosen kennzeichnet zumeist ein schwer verlaufende Erkrankung. Ursächlich kann beim immunoinkompetenten Patienten nahezu jeder Erreger in Frage kommen. Biopsie sowie Gewebekultur aus den meist ulzerativen Veränderungen können die Diagnose sichern. Die meisten superfiziellen Infektionen sprechen zufriedenstellend auf eine topische antimykotische Behandlung an, insbesondere wenn Provokationsfaktoren und die Möglichkeit der sexuellen Transmission berücksichtigt werden. Ausgedehnte Infektionen durch Dermatophyten, Hefen und natürlich systemische Infektionen erfordern eine systemische antimykotische Therapie.

Defecography - analysis of qualitative findings; Evakuationsproktographie - Analyse qualitativer Befunde

Energy Technology Data Exchange (ETDEWEB)

Schott, U. [Tuebingen Univ. (Germany). Abt. Radiologische Diagnostik; Braunschweig, R. [Tuebingen Univ. (Germany). Abt. Radiologische Diagnostik; Claussen, C.D. [Tuebingen Univ. (Germany). Abt. Radiologische Diagnostik

1994-12-31

The defectography is an examination of the anorectal function in defecatory disorder. The defecography has a diagnostic impact on disease, which only emerge during defecation as intussusception, enterocele, prolapse or sphincter dysfunction. Other findings as rectocele or descending pelvic floor are ambiguous concerning clinical relevance. The interpretation of defecography should include patient`s history and clinical findings and - if available - endoscopic and manometric findings. (orig.) [Deutsch] Die Evakuationsproktographie ist eine Funktionsuntersuchung des Anorektums beim Symptomenkreis der Defaekationsbeschwerden. Die Domaene der Evakuationsproktographie sind Erkrankungen, die sich nur unter den Provokationsbedingungen der Defaekation manifestieren, wie die Intussuzeption, Enterocele, temporaerer Wandprolaps oder Anismus. Andere Befunde wie eine Rektocele oder Beckenbodenschwaeche sind in ihrer klinischen Relevanz umstritten. Die Bewertung der Evakuationsproktographie im Rahmen des Beschwerdebildes des Patienten sollte in Zusammenschau von vollstaendiger anamnestischer und klinischer Information und - sofern vorhanden - Befunden von Rektoskopie und Rektummanometrie erfolgen. (orig.)

Female teams im eSport: Re-Konstruktion der Kategorie Geschlecht

OpenAIRE

Streubel, Anett

2010-01-01

"Das Ziel dieses Papers ist es, die Herausbildung von "female Teams" im eSport zu untersuchen. Das Hauptaugenmerk liegt hierbei auf Rekonstruktionsmechanismen der Kategorie Geschlecht, welche durch Sprache und Diskurse gebildet, erlernt und fortgeführt werden. Der Anteil der Spielerinnen, die das Computerspielen als Sport betreiben, wächst stetig an - deshalb soll in dieser Studie der Profibereich des eSport näher betrachtet werden. In einem Tätigkeitsfeld, in dem nicht der Körper im Mittelpu...

Zur mediopassiven 2. Und 3. Person dualis im indogermanischen

Directory of Open Access Journals (Sweden)

Bojan Čop

1972-12-01

Full Text Available Bekanntlich gibt es in einigen seltenen idg. Sprachen (im Arischen, Griechischen, Tocharischen auch Personal - suffixe für die 2. u n d 3. P. Du. des Mediopassivs. Von diesen sind die griechischen Ausgänge – 2. und 3. Du primär, 2. Du. sekundär, Du. sekundär sicher junge Neubildungen, s. z. B. Brugmann, Grdr.2 II 3 II, 657, § 602; Schwyzer, Gr. Gr. I 670, 672. Ein voll ausgebildetes System solcher Endungen besitzt das Arische; im Tocharischen kommt nur eine einzige Form mit solcher Endung vor, die die 2. P. Du. Med. lmperativi darstellt. Unter solchen Umständen scheint es schwierig, aus diesem Material wahrscheinliche Schlüsse für da_s Urindogermanische zu machen. Und doch ist gerade die tocharische Form, die uns eine ausserordentlich grosse Hilfe leistet, wenn man sie richtig zu beurteilen vermag. Die tocharische Endung, verbunden mit den arischen, wird unter Einschluss der allgemeinen Tendenzen und Regelungen im System der indogermanischen Personalsuffixe ohne Schwierigkeit die urindogermanische Urform erscheinen lassen.

[Glanz und Elend - Mythos und Wirklichkeit der Herrenhäuser im Baltikum] / Karsten Brüggemann

Index Scriptorium Estoniae

Brüggemann, Karsten, 1965-

2014-01-01

Arvustus: Glanz und Elend - Mythos und Wirklichkeit der Herrenhäuser im Baltikum. Hrsg. von Ilse von zur Mühlen im Auftrag der Carl-Schirren-Gesellschaft e.V. und des Ostpreußischen Landesmuseums Lüneburg. Kunstverlag Josef Fink. Lindenberg im Allgäu 2012

Season of infectious mononucleosis and risk of multiple sclerosis at different latitudes; the EnvIMS Study.

Science.gov (United States)

Lossius, Andreas; Riise, Trond; Pugliatti, Maura; Bjørnevik, Kjetil; Casetta, Ilaria; Drulovic, Jelena; Granieri, Enrico; Kampman, Margitta T; Landtblom, Anne-Marie; Lauer, Klaus; Magalhaes, Sandra; Myhr, Kjell-Morten; Pekmezovic, Tatjana; Wesnes, Kristin; Wolfson, Christina; Holmøy, Trygve

2014-05-01

Seasonal fluctuations in solar radiation and vitamin D levels could modulate the immune response against Epstein-Barr virus (EBV) infection and influence the subsequent risk of multiple sclerosis (MS). Altogether 1660 MS patients and 3050 controls from Norway and Italy participating in the multinational case-control study of Environmental Factors In Multiple Sclerosis (EnvIMS) reported season of past infectious mononucleosis (IM). IM was generally reported more frequently in Norway (p=0.002), but was associated with MS to a similar degree in Norway (odds ratio (OR) 2.12, 95% confidence interval (CI) 1.64-2.73) and Italy (OR 1.72, 95% CI 1.17-2.52). For all participants, there was a higher reported frequency of IM during spring compared to fall (p<0.0005). Stratified by season of IM, the ORs for MS were 1.58 in spring (95% CI 1.08-2.31), 2.26 in summer (95% CI 1.46-3.51), 2.86 in fall (95% CI 1.69-4.85) and 2.30 in winter (95% CI 1.45-3.66). IM is associated with MS independently of season, and the association is not stronger for IM during spring, when vitamin D levels reach nadir. The distribution of IM may point towards a correlation with solar radiation or other factors with a similar latitudinal and seasonal variation.

Finanzmärkte – Unternehmungen – Informationen: Ergebnisse des Projektes im Wintersemester 2016/2017

OpenAIRE

Geyer, Helmut; Grau, Svenja; Giersch, Peter; Eckardt, Maximilian; Eder, Josephin; Catholy, Victoria; Pisak, Anastasia; Löser, Matthias; Jehring, Maximilian; Zhang, Haoyang; Grabengießer, Anja; Gruschwitz, Karoline; Heinrich, Katharina; Patzer, Vivien; Päsler, Florian

2018-01-01

Der vorliegende Beitrag der Wirtschaftswissenschaftlichen Schriften ist ein Sammelband, der die Beiträge der Studierenden des 2. Fachsemesters im Masterstudiengang General Management aus dem Wintersemester 2016/2017 umfasst. Die Einzelbeiträge wurden in einer zwei Monate dauernden Projektarbeit im Herbst 2016 erarbeitet und im Januar 2017 präsentiert. Der Themenschwerpunkt für dieses Jahr lag auf dem Bereich "Immobilien/Wohnungspolitik". Innerhalb dieser Vorgabe wurde ein breites Spektrum bea...

An IMS testbed for SIP applications

DEFF Research Database (Denmark)

Caba, Cosmin Marius; Soler, José

2013-01-01

The paper presents the design and implementation of an emulation platform for the IP Multimedia Subsystem. The SIP Servlet API v1.1 has been used to implement the final system. The purpose of the emulation is to offer to IMS service developers an environment where they can integrate development...

Datengeleitetes Lernen im studienbegleitenden Deutschunterricht am Beispiel des KoGloss-Ansatzes

OpenAIRE

Dubova, Agnese; Proveja, Egita

2016-01-01

Der vorliegende Aufsatz stellt den sprachdidaktischen Ansatz KoGloss vor und beschreibt die Möglichkeiten seines Einsatzes im studienbegleitenden Deutschunterricht. Als eine der Formen des datengeleiteten Lernens ermöglicht der KoGloss-Ansatz eine forschungsorientierte und lernerzentrierte Herangehensweise, die insbesondere im akademischen Sprachunterricht gefragt ist. Eine korpusbasierte Erschließung von (Fach-)Wörtern und komplexen sprachlichen Mustern, das learning by doing, die Kooperatio...

IMS IN SMES - REASONS, ADVANTAGES AND BARRIERS ON IMPLEMENTATION

Directory of Open Access Journals (Sweden)

Dragan Rajković

2008-09-01

Full Text Available Appearance of a number of management systems with various and sometimes divergent demands, demands for revise of optimal strategy on implementation of these standards in small and medium-sized enterprises (SMEs and the attempt on their integration into integrated management system are suggested even more. Firstly question on choice and reasons for implementation of standards is raised. Management and employees expect benefits on the implementation and they pass and minimize the implementation barriers. Basic concept on integrated management system (IMS into SMEs and analyse on reasons, advantages and barriers at IMS implementation are presented in this paper.

Reconocimiento de imágenes utilizando redes neuronales artificiales

OpenAIRE

García García, Pedro Pablo

2013-01-01

Este trabajo describe el proceso de extracción de patrones característicos de imágenes,mediante la ayuda de Redes Neuronales Artificiales. La información de la Red Neuronal junto con datos adicionales de las imágenes, serán almacenados en una base de datos y consumidos por un servicio web. Un teléfono móvil con sistema operativo Android consumirá la información almacenada en el servicio web. Posteriormente al realizar una captura de imagen con la cámara del teléfono, este procesará la imag...

Malignant Catatonia

Directory of Open Access Journals (Sweden)

Ayca Ozkul

2010-12-01

Full Text Available Catatonia is a syndrome characterized by mutism, immobility, negativism, stereotypy, mannerisms, echophenomena, perseveration and passive obedience. The underlying causes can be psychiatric or may be associated with general medical status or neurological diseases. Additionally catatonia has two subtypes as malignant and nonmalignant catatonia. Main symptoms of malignant catatonia are hyperthermia and autonomic symptoms such as tachycardia, tachypnea and hyperhidrosis. It is important to make the diagnosis as early as possible for an appropriate medical treatment. Clinicians should be aware of the fatal outcome of the disease.

MRI of the musculature in patients with myalgia - indications and imaging results; MRT der Muskulatur bei Myalgien - Indikationen und Bildbefunde

Energy Technology Data Exchange (ETDEWEB)

Beese, M.S. [Universitaetsklinik Hamburg-Eppendorf (Germany). Radiologische Klinik; Winkler, G. [Universitaetsklinik Hamburg-Eppendorf (Germany). Neurologische Klinik; Maas, R. [Universitaetsklinik Hamburg-Eppendorf (Germany). Radiologische Klinik; Buechler, E. [Universitaetsklinik Hamburg-Eppendorf (Germany). Radiologische Klinik

1996-05-01

Einschlusskoerpermyositiden bestand mit der Befundbetonung in der Quadrizepsmuskulatur ein einheitliches Verteilungsmuster. Erregerbedingte Myositiden, fokale Myositiden und Rhabdomyolysen wiesen im Gegensatz zu anderen neuromuskulaeren Erkrankungen ein starkes KM-Enhancement auf. Myalgische Syndrome ohne weiteren pathologischen neurologischen Befund waren ohne Ausnahme und Patienten mit Polymyalgia rheumatica in 86% unauffaellig. Die Kernspintomographie erlaubte den sicheren Ausschluss entzuendlicher, tumoroeser oder rhabdomyolysebedingter Ursachen einer Myalgie und lieferte bei diesen Erkrankungen pathognomonische Befunde. Erkrankungen aus der Gruppe der endokrinen, toxischen und metabolischen Myopathien koennen in der MRT hingegen unauffaellig sein. (orig./MG)

CT of malignant otitis externa

International Nuclear Information System (INIS)

Klose, K.C.; Elies, W.; Technische Hochschule Aachen

1991-01-01

Computed tomography was performed preoperatively in 20 patients suffering from malignant external otitis. The CT findings were nearly completely confirmed by the intraoperative findings. A circumscribed or diffuse thickening of the cartilaginous wall of the external auditory canal and an inflammatory infiltration of the subtemporal fossa are, in combination, most suspicious signs of malignant external otitis. Computed tomography enabels detailed information on the extension of the pneumatic system and the grade of involvement of bones and soft tissues in malignant external otitis. A modified classification of malignant external otitis based on computed tomographic findings is proposed. (orig.) [de

Spontane Mobilisierung und der Wandel kollektiver Formationen im Internet. Eine Fallstudie zur PEGIDA-Bewegung

Directory of Open Access Journals (Sweden)

Sang-hui Nam

2016-11-01

Full Text Available Der vorliegende Beitrag beschäftigt sich mit der Frage, wie sich eine aus spontaner Mobilisierung entstandene soziale Bewegung als kollektive Formation im Internet entwickelt. Da spontane Bewegungen in aller Regel nur über eine schwache kollektive Identität verfügen, werden sie bislang überwiegend als Übergangsphänomen betrachtet. Viele Studien beschäftigten sich eher mit den Folgen spontaner Mobilisierung, insbesondere der Frage, wie daraus eine nachhaltige Bewegung entstehen kann. Die kollektive Formation selbst ist bis dato weitgehend eine Blackbox geblieben. In der vorliegenden Studie widme ich mich folgenden zentralen Forschungsfragen: 1. Wie werden kollektive Formationen aus spontanen ProtestteilnehmerInnen dargestellt und generiert? 2. Wie ändern sich diese im Verlauf der Mobilisierung? Im Mittelpunkt der empirischen Analyse stehen Online-Kommentare, die eine zunehmend wichtige Rolle für soziale Bewegungen und spontane Mobilisierungsprozesse spielen. Am Beispiel von PEGIDA wird die Konstruktion einer kollektiven Formation über Live-Kommentare zu Live-Übertragungen von PEGIDA-Demonstrationen sowie deren Wandel in drei Phasen untersucht. Im ersten Schritt werden die soziotechnischen Grundlagen kollektiven Handelns im Internet erläutert. Der zweite Schritt befasst sich mit der methodischen Vorgehensweise. Im dritten Schritt werden ausgewählte Textpassagen von Online-Kommentaren analysiert. Anschließend wird der Wandel kollektiver Formationen nachgezeichnet. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs170138

Professionalisierung und Doping im Sport

OpenAIRE

Wüterich, Christoph

2004-01-01

Der Beitrag untersucht Zusammenhänge zwischen der zunehmenden Professionalisierung des Sports und dem Anstieg von Dopingvergehen. Er zeigt, dass im historischen Vergleich beide Phänomene nicht neu sind, dass sich die Probleme aufgrund der steigenden Bedeutung des Leistungssports aber zugespitzt haben. Ausgehend von einer juristischen und sozioökonomischen Analyse der Anreize zu Doping werden Lösungsvorschläge entwickelt. The author analyzes the interdependencies between a growing commercia...

Radiotherapy of malignant lymphomas

Energy Technology Data Exchange (ETDEWEB)

Kujawska, J [Instytut Onkologii, Krakow (Poland)

1979-01-01

The paper discusses current views on the role of radiotherapy in the treatment of patients with malignant lymphomas. Principles of radiotherapy employed in the Institute of Oncology in Cracow in case of patients with malignant lymphomas are also presented.

P16.29 Malignant craniopharyngioma

Science.gov (United States)

Unal, E.; Kilic, K.; Ozdemir, N.; Gunver, F.; Isik, S.; Can, S.

2017-01-01

Abstract Introduction: Malignant transformation of craniopharyngioma has rarely been described. In this article, we report a case of 28th malignant craniopharyngioma ever mentioned in English literature. Materials and Methods: We performed a PUBMED, HUBMED, BAU Library Database and Ovid search on malignant craniopharyngiomas and identified 27 reported cases. CASE DESCRIPTION: 44 years old female patient was diagnosed with craniopharyngioma two years ago and underwent surgical resection of a typical craniopharyngioma, the histopathological result was adamantinomatous craniopharyngioma of Grade I. There was no malignancy. One year ago cavernous sinus invasion has been detected and gamma knife irradiation has been made. At admission she was blind in the right eye for the last six months and the vision was diminished in the left eye for a month. The MRI showed that nasal cavity was full of tumor, that the clivus was almost completely destructed and that orbita and maxillary sinus were also invaded. Firstly the ENT surgeons debulked the tumor via transmaxillary route and then the transcranial approach allowed only a subtotal removal due to a profuse bleeding. The histopatological examination showed malignant tumoral infiltration rich in cells with many mitoses. The patient died two years later. CONCLUSION: The relevant literature of malignant craniopharyngioma is reviewed and discussed. The surgeon must be aware that total removal of a malignant craniopharyngioma can be hazardous because of intractable bleedings occurring during surgery.

bildbild – visuelle Kompetenz im Unterricht

Directory of Open Access Journals (Sweden)

Norbert Grube

2013-05-01

Full Text Available Der vorliegende Artikel stellt das Webseiten-Projekt bildbild vor. Der Webseite liegt die Motivation zugrunde, Schülerinnen und Schüler für ein Nachdenken über globale Themen zu sensibilisieren. Ein solches Nachdenken ist immer auch eines über bildlich vermittelte Wirklichkeit. Es ist mit bildbild ein Anliegen, angesichts einer allseits konstatierten «Bilderflut» ein didaktisches Medium zu entwickeln, das einen Fundus an historischen und aktuellen Fotografien zur Verfügung stellt und diese so aufbereitet, dass sie gerade nicht hinter ihrer illustrativen Funktion verschwinden. Dadurch sollen die Bilder für ein selbständiges Lernen auf dem Weg hin zu einer visuellen Kompetenz einsetzbar gemacht werden. Der Beitrag beleuchtet die Entwicklung der Webseite vor dem Hintergrund kulturkritischer Haltungen zum Bild seit der Moderne sowie im Rahmen dessen, was seit den 1970er Jahren im pädagogischen Kontext als Visual Literacy diskutiert und gefördert wird. Dabei wird auch auf die medialen Potenziale einer Webseite für die Bildlesekompetenz von Jugendlichen eingegangen.

A plan for location calibration of IMS stations and near Kazakhstan

International Nuclear Information System (INIS)

Richards, P.G.; Kim, W.-Yo.; Khalturin, V.I.

2001-01-01

For purposes of monitoring compliance with the Comprehensive Nuclear Test-Ban Treaty, it is desirable to be able to locate seismic events routinely to within an uncertainty not greater than 1000 square km. From more than five years of experience with publication of the Reviewed Event Bulletin (REB) by the Prototype International Data Centre (PIDC), resulting in estimated locations for more than 100,000 seismic events, it is apparent that improved location accuracy is needed in order to reduce uncertainties below 1000 square km. In this paper, we outline a three-year program of applied research which commenced in March 2000 and which has the goal of achieving improved REB locations based upon data to be contributed to the International Data Centre from 30 IMS stations in Eastern Asia. Our first efforts will focus on the four IMS seismographic stations in Kazakhstan (AKT, BRV, KUR, MAK), together with IMS stations ZAL in Russia and AAK in Kyrgyzstan. Following the recommendations of two 'IMS Location Calibration Workshops' held in Oslo, Norway, in 1999 and 2000, our approach is to generate station-specific travel times for each observable seismic phase, as a function of distance and azimuth (and depth, where possible). Such travel times are obtained on the basis of (i) early studies based mainly on earthquake data (e.g. Nersesov and Rautian, 1964), (ii) Deep Seismic Sounding, and (iii) recent studies of nuclear and chemical explosions. We are also using (iv) an empirical approach in which phases are picked at IMS stations, for so-called Ground Truth events whose location is known quite accurately on the basis of additional data, obtained for example from local and regional networks. (author)

IMS Learning Design: De stand van zaken

NARCIS (Netherlands)

Tattersall, Colin; Manderveld, Jocelyn

2005-01-01

Tattersall, C. & Manderveld, J. (2004) IMS Learning Design: De stand van zaken In: Gorissen, P., Manderveld, J., Benneker, F. & Cordewener, B. Leertechnologie in de Lage Landen (pp. 31-33). Utrecht, Stichting Surf. Ook beschikbaar in dspace: http://hdl.handle.net/1820/270

[Christofer Herrmann. Kloster und Burg - die architektur des Deutschens Ordens im Pressen und Livland. In : Glaube, Macht und Pracht. GeistlicheGemeinschaften des Ostseeraums im Zeitalter der Backsteingotik] / Dennis Hortmuth

Index Scriptorium Estoniae

Hortmuth, Dennis

2011-01-01

Arvustus: Christofer Herrmann. Kloster und Burg - die Architektur des Deutschen Ordens in Preussen und Livland. In : Glaube, Macht und Pracht. GeistlicheGemeinschaften des Ostseeraums im Zeitalter der Backsteingotik (=Archäologie und Geschichte im Ostseeraum; Archaeology and History of the Baltic 6) Rahden : Verlag Marie Leidorf, 2009. S. 209-219. Saksa Ordu arhitektuurist Preisi- ja Liivimaal

Evaluation of the Indian Migration Study Physical Activity Questionnaire (IMS-PAQ): a cross-sectional study.

Science.gov (United States)

Sullivan, Ruth; Kinra, Sanjay; Ekelund, Ulf; Bharathi, A V; Vaz, Mario; Kurpad, Anura; Collier, Tim; Reddy, K Srinath; Prabhakaran, Dorairaj; Ebrahim, Shah; Kuper, Hannah

2012-02-09

Socio-cultural differences for country-specific activities are rarely addressed in physical activity questionnaires. We examined the reliability and validity of the Indian Migration Study Physical Activity Questionnaire (IMS-PAQ) in urban and rural groups in India. A sub-sample of IMS participants (n = 479) was used to examine short term (≤ 1 month [n = 158]) and long term (> 1 month [n = 321]) IMS-PAQ reliability for levels of total, sedentary, light and moderate/vigorous activity (MVPA) intensity using intraclass correlation (ICC) and kappa coefficients (k). Criterion validity (n = 157) was examined by comparing the IMS-PAQ to a uniaxial accelerometer (ACC) worn ≥ 4 days, via Spearman's rank correlations (ρ) and k, using Bland-Altman plots to check for systematic bias. Construct validity (n = 7,000) was established using linear regression, comparing IMS-PAQ against theoretical constructs associated with physical activity (PA): BMI [kg/m2], percent body fat and pulse rate. IMS-PAQ reliability ranged from ICC 0.42-0.88 and k = 0.37-0.61 (≤ 1 month) and ICC 0.26 to 0.62; kappa 0.17 to 0.45 (> 1 month). Criterion validity was ρ = 0.18-0.48; k = 0.08-0.34. Light activity was underestimated and MVPA consistently and substantially overestimated for the IMS-PAQ vs. the accelerometer. Criterion validity was moderate for total activity and MVPA. Reliability and validity were comparable for urban and rural participants but lower in women than men. Increasing time spent in total activity or MVPA, and decreasing time in sedentary activity were associated with decreasing BMI, percent body fat and pulse rate, thereby demonstrating construct validity. IMS-PAQ reliability and validity is similar to comparable self-reported instruments. It is an appropriate tool for ranking PA of individuals in India. Some refinements may be required for sedentary populations and women in India.

MIP-based enhanced mid-session macro-mobility for IMS-controlled state-full applications

DEFF Research Database (Denmark)

Renier, Thibault Julien; Fathi, Hanane; Schwefel, Hans-Peter

2007-01-01

, e.g., block unauthorized visiting users. The 3GPP IP Multimedia Subsystem (IMS) is a platform standardized towards network-independent access and session control. The current IMS specifications do not allow for any change of the user's current IP address during an ongoing session, which prevents...

Pragmatic awareness of Suggestions: From (Im)Polite Mannerism to Attitudinal Appropriateness

OpenAIRE

Hamid Allami; Nasim Boustani

2017-01-01

The present research seeks to determine: (a) Iranian EFL learners’ application of suggestion semantic formulae ;(b) their attitude of appropriateness in terms of confidence in the employment of appropriate supportive moves; (c), their (im)polite mannerism with respect to the selected strategies; and (d) the relationship between attitude of appropriateness and mannerism of (im)politeness. An Oxford Quick placement Test (OQPT) was administered among 60 Iranian EFL learners to check their langua...

Produkteinführung im Umfeld des Niedergangs: Die Blu-ray Disk

OpenAIRE

Oestreicher, Klaus; Walton, Nigel; Newnham, M.

2014-01-01

Dieses Kapitel diskutiert die Problematik existenzieller Bedrohung durch radikale Innovationen. Virtuelle Marktangebote verändern Märkte im Home Entertainment und das Konsumverhalten grund¬legend. Zunehmend gefährden dematerialisierte Produkte, welche zu Services werden und Folge der Information Communication Tech¬nologies (ICT) sind, die Lebensfähigkeit physischer Produkte. Deren Märkte sind im Niedergang und das bedroht nicht nur die Hersteller optischer Disks (CD und DVD), sondern beeinflu...

Malignant chondroid syringoma of the pinna

International Nuclear Information System (INIS)

Krishnamurthy, Arvind; Aggarwal, Niharika; Deen, Suhail; Majhi, Urmila; Ramshankar, Vijayalakshmi

2015-01-01

Chondroid syringoma (CS) represents the cutaneous counterpart of mixed tumor (pleomorphic adenoma) of salivary glands. The malignant counterpart of CS, termed as “malignant CS” is a malignant eccrine neoplasm which lacks distinctive clinical features, often delaying initial diagnosis. Unlike its benign counterpart which often localizes in the head and neck region, malignant CS most often encountered in the trunk and the extremities. We report a rare case of an aggressive malignant CS of the left pinna with cervical lymph node metastasis. Our patient, to the best of our knowledge, possibly is the first case of malignant CS of the pinna and the fourth to arise in the head and neck region. The diagnostic challenges with an added emphasis on the role of positron emission tomography-computed tomography in aiding the management of this rare tumor are discussed

The role of tumor necrosis factor alpha in differentiation between malignant and non malignant pleural effusion

Directory of Open Access Journals (Sweden)

Heba M. Atef

2016-07-01

Conclusion: Pleural fluid level of TNF-α can be used in differentiating malignant from non malignant effusion. Also levels of TNF-α in the serum and pleural fluid could be useful as a complementary marker in the differential diagnosis of two most common types of exudates (tuberculous and malignant.

Facebook Ethnography: The Poststructural Ontology of Transnational (Im Migration Research

Directory of Open Access Journals (Sweden)

David Joseph Piacenti PhD

2014-02-01

Full Text Available This theoretical article discusses the creative utility of Facebook as a new ethnographic tool in which to study transnational (im migration. Facebook ethnography allows the (im migration researcher to transcend the four structural dualities that constrain transnational ethnographic research: (a geographic constraints, (b travel funding constraints, (c travel time constraints, and (d the logistical constraints of entrée into new ethnographic contexts. Facebook ethnography also allows the qualitative researcher to temporarily transcend the ontological structuralist dualities of traditional research methods, producing a new poststructural epistemological and ontological methodology.

A flicker noise/IM3 cancellation technique for active mixer using negative impedance

NARCIS (Netherlands)

Cheng, W.; Annema, Anne J.; Wienk, Gerhardus J.M.; Nauta, Bram

2013-01-01

Abstract—This paper presents an approach to simultaneously cancel flicker noise and IM3 in Gilbert-type mixers, utilizing negative impedances. For proof of concept, two prototype double-balanced mixers in 0.16- m CMOS are fabricated. The first demonstration mixer chip was optimized for full IM3

78 FR 79498 - Notice Pursuant to The National Cooperative Research and Production Act of 1993-IMS Global...

Science.gov (United States)

2013-12-30

... Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on November 22....C. Sec. 4301 et seq. (``the Act''), IMS Global Learning Consortium, Inc. (``IMS Global'') has filed..., Carson-Dellosa Publishing, Greensboro, NC; Data Recognition Group, Maple Grove, MN; Nelson Education Ltd...

78 FR 7456 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

Science.gov (United States)

2013-02-01

... District, Selbyville, DE; learning.com , Portland, OR; State of Michigan Dept. of Education, Bureau of... Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on December 28....C. 4301 et seq. (``the Act''), IMS Global Learning Consortium, Inc. (``IMS Global'') has filed...

Meta-analysis of the predictive value of DNA aneuploidy in malignant transformation of oral potentially malignant disorders.

Science.gov (United States)

Alaizari, Nader A; Sperandio, Marcelo; Odell, Edward W; Peruzzo, Daiane; Al-Maweri, Sadeq A

2018-02-01

DNA aneuploidy is an imbalance of chromosomal DNA content that has been highlighted as a predictor of biological behavior and risk of malignant transformation. To date, DNA aneuploidy in oral potentially malignant diseases (OPMD) has been shown to correlate strongly with severe dysplasia and high-risk lesions that appeared non-dysplastic can be identified by ploidy analysis. Nevertheless, the prognostic value of DNA aneuploidy in predicting malignant transformation of OPMD remains to be validated. The aim of this meta-analysis was to assess the role of DNA aneuploidy in predicting malignant transformation in OPMD. The questions addressed were (i) Is DNA aneuploidy a useful marker to predict malignant transformation in OPMD? (ii) Is DNA diploidy a useful negative marker of malignant transformation in OPMD? These questions were addressed using the PECO method. Five studies assessing aneuploidy as a risk marker of malignant change were pooled into the meta-analysis. Aneuploidy was found to be associated with a 3.12-fold increased risk to progress into cancer (RR=3.12, 95% CI 1.86-5.24). Based on the five studies meta-analyzed, "no malignant progression" was more likely to occur in DNA diploid OPMD by 82% when compared to aneuploidy (RR=0.18, 95% CI 0.08-0.41). In conclusion, aneuploidy is a useful marker of malignant transformation in OPMD, although a diploid result should be interpreted with caution. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

SISTEMAS MULTIMEDIA BASADOS EN PROTOCOLO IP IMS APLICADOS A SERVICIOS LTE DE 4G

Directory of Open Access Journals (Sweden)

Edgar Alfonso Cipagauta Pedraza

2013-01-01

Full Text Available Este artículo presenta de una manera sencilla, el sistema creado para soportar los servicios de multimedia dentro de red de nueva generación (NGN llamada IP Multimedia Subsystem (IMS a la vez que se explica su relación con la tecnología Long Term Evolution (LTE definida por el 3GPP en su release 8. IMS se trata de una arquitectura integrada en el núcleo de red para ofrecer servicios multimediales de audio y video sobre una infraestructura. Entonces ahora, los servicios prestados pasarán a ser ofrecidos a través de IP IMS y será la piedra angular en donde estos servicios se generarán y se ofrecerán. LTE es sin duda un impulsor de IMS, pero hay otros factores que empiezan a favorecer y a plantear un modelo de negocio favorable para la arquitectura multimedia. IMS está orientado a habilitar la convergencia de servicios, combinando el crecimiento de la Internet con el de las comunicaciones móviles, desde cualquier ubicación y método de forma continua y permanente.

EXTREMISMUS IM KLASSENZIMMER - THEORETISCHE CHANCEN UND MÖGLICHKEITEN DES POLITIKUNTERRICHTES.

Directory of Open Access Journals (Sweden)

Amelie Zuschke

2015-06-01

Full Text Available Durch Phänomene wie PEGIDA wird eine Unsicherheit in der Bevölkerung ausgedrückt, die auch vor den Schultüren nicht Halt macht. Ein Querschnitt der Gesellschaft sitzt im Klassenraum und auf diesen muss sich eingestellt werden. Ob Kinder zuhause oder in ihrer Freizeit mit Populismus konfrontiert werden, die Schule hat als immer größerer Teil im Leben von Schülern in Deutschland (im Zuge der nach und nach fortschreitenden Einführung eines Ganztages-Prinzips auch eine Verantwortung mit diesen Eindrücken und Einflüssen bedacht umzugehen. Deutschland sollte aus der eigenen Geschichte heraus zudem die aufmerksame und sensible Handhabung mit extremem Gedankengut im Allgemeinen und mit rechtsextremistischem Gedankengut im Besonderen haben. Die Tendenz zu den politischen Extremen in wirtschaftlich und sozial herausfordernden Zeiten ist ein mit jedem wirtschaftlichen Abschwung auftretendes Phänomen, aber stark nationalistisches Gedankengut ist mit der heutigen Idealvorstellung von einem offenen Europa nicht vereinbar. In der Bundesrepublik Deutschland fußt die politische Bildung, geschichtlich begründet, auf demokratievermittelnden Prinzipien. Diese eignen sich vielseitig für die Auseinandersetzung mit Extremismus und den hierzu unumstrittenen Grundlagen und Werte der pluralistischen Gesellschaft in einer Demokratie. Das Kontroversitätsgebot des Beutelsbacher Konsenses aus dem Jahr 1977 (vgl Breit/Massig, 1993 bietet einen Ansatz zur Behandlung von Extremismus in der politischen Bildung auf der Grundlage der gegenseitigen Akzeptanz. Hier wird das Kontroversitätsgebot aufgeschlüsselt und anschließend auf Extremismus in der Schule bezogen. Die Fragestellung, wie der Politikunterricht trotz des Kontroversitätsgebotes mit Extremismus umgehen sollte, ist auf den Umgang mit dem gegenwärtigen Rechtsextremismus ausgelegt, welcher einen großen Teil politisch motivierter Straftaten begründet, sich in radikalisierter Form am stärksten gegen

Entwicklung der Reglementierung von 10 MEM-Berufen im Kontext von Bildungsreformen und dem Wandel in der Arbeitswelt: Eine Kurzstudie im Auftrag von LIBS: Eine Kurzstudie im Auftrag von LIBS Industrielle Berufslehren Schweiz, Baden

OpenAIRE

Egg, Maria Esther; Renold, Ursula

2015-01-01

Im Auftrag der LIBS Industrielle Berufslehren Schweiz, hat die KOF die Entwicklung von 10 MEM1-Berufsbildern seit dem ersten Berufsbildungsgesetz dargestellt und diese eingebettet in eine kurze Zusammenfassung der wichtigsten Etappenschritte des Schweizer Berufsbildungssystems.

Retroperitoneal extension via the retrocrural space of malignant thymoma and malignant pleural mesothelioma. Retrospective evaluation by CT

Energy Technology Data Exchange (ETDEWEB)

Ohkawara, Kiyoshi; Furuse, Makoto; Mizutani, Yoshihide; Ohsawa, Tadashi; Fujii, Takeshi [Jichi Medical School, Minamikawachi, Tochigi (Japan)

1995-01-01

We reviewed CT findings of 31 patients with malignant thymoma and one patient with malignant pleural mesothelioma in our institution. Transdiaphragmatic extension into the retroperitoneum via the retrocrural space was observed in 10% of malignant thymomas. In the same way, this spread from chest to abdomen was demonstrated in the case of malignant pleural mesothelioma. CT is especially useful in assessing extent of these tumors and determining the optimal treatment plan. (author).

Retroperitoneal extension via the retrocrural space of malignant thymoma and malignant pleural mesothelioma. Retrospective evaluation by CT

International Nuclear Information System (INIS)

Ohkawara, Kiyoshi; Furuse, Makoto; Mizutani, Yoshihide; Ohsawa, Tadashi; Fujii, Takeshi

1995-01-01

We reviewed CT findings of 31 patients with malignant thymoma and one patient with malignant pleural mesothelioma in our institution. Transdiaphragmatic extension into the retroperitoneum via the retrocrural space was observed in 10% of malignant thymomas. In the same way, this spread from chest to abdomen was demonstrated in the case of malignant pleural mesothelioma. CT is especially useful in assessing extent of these tumors and determining the optimal treatment plan. (author)

IMS Learning Design desde dentro. Una especificación para crear escenarios de aprendizaje online (parte I)

NARCIS (Netherlands)

Burgos, Daniel; Berbegal, Nidia; Griffiths, David; Tattersall, Colin; Koper, Rob

2005-01-01

IMS Learning Design, IMS LD de ahora en adelante (IMS, 2003), es una especificación centrada en formación online o e-learning y que permite modelar programaciones curriculares o lecciones presenciales de forma que puedan ser seguidas online, construyendo lo que se denomina Unidades de Aprendizaje

Aplicativo Web para la Fusión de Imágenes Satelitales

Directory of Open Access Journals (Sweden)

Javier Medina

2013-06-01

Full Text Available En este artículo se implementa un servicio en la Web que ofrece la posibilidad de realizar la fusión de imágenes de satélite. A lo largo del artículo tres temáticas importantes son abordadas. La primera temática corresponde al servicio Web, éste servicio es implementado usando software libre, donde el usuario puede realizar una solicitud del servicio de fusión. La segunda temática se ocupa del análisis de la transformada rápida de Wavelet haar (TRWH. La última temática detalla la metodología, para realizar la fusión de imágenes usando la TRWH. Con el fin de determinar la eficiencia de la TRWH, cinco Wavelets diferentes fueron implementadas para fusionar el mismo par de imágenes satelitales. Las imágenes resultantes fueron evaluadas tanto en la calidad espacial como espectral a través de cuatro índices. Los mejores resultados de la evaluación fueron obtenidos con la TRWH la cual preserva la riqueza espectral y mejora su calidad espacial

Original models of NGN/IMS-networks surrounded by circuit-switched systems

OpenAIRE

Kulikov, Nikolay

2014-01-01

On obtaining of the Alexander Graham Bell a patent for invention of the telephone in 1987, the communication system consistently has gone through several evolutionary stages: from analog lines and manual switches to video telephony and IMS architecture. Each of the stages can be described by specific switching systems, data transmission systems and types of transmitted information. After implementation of such solution, it is possible to create a number of access nodes in the Operators IMS-ne...

An IMS Station life cycle from a sustainment point of view

Science.gov (United States)

Brely, Natalie; Gautier, Jean-Pierre; Foster, Daniel

2014-05-01

The International Monitoring System (IMS) is to consist of 321 monitoring facilities, composed of four different technologies with a variety of designs and equipment types, deployed in a range of environments around the globe. The International Monitoring System is conceived to operate in perpetuity through maintenance, replacement and recapitalization of IMS facilities' infrastructure and equipment when the end of service life is reached [CTBT/PTS/INF.1163]. Life Cycle techniques and modellization are being used by the PTS to plan and forecast life cycle sustainment requirements of IMS facilities. Through historical data analysis, Engineering inputs and Feedback from experienced Station Operators, the PTS currently works towards increasing the level of confidence on these forecasts and sustainment requirements planning. Continued validation, feedback and improvement of source data from scientific community and experienced users is sought and essential in order to ensure limited effect on data availability and optimal costs (human and financial).

Malignant vagal paraganglioma

DEFF Research Database (Denmark)

Carlsen, Camilla S; Godballe, Christian; Krogdahl, Annelise S

2003-01-01

Approximately 20 cases of malignant vagal paragangliomas (MVP)have been reported in English literature. Malignancy is based on the presence of metastases. A careful preoperative evaluation is necessary to detect multicentricity and/or significant production of catecholamines. A new case of MVP...... treated with embolization and surgery is presented and the literature discussed. It is concluded, that preoperative embolization followed by radical surgical resection is a rational treatment of patients with unilateral MVP....

International Monitoring system (IMS) build-up in Africa: Current status and the way forward

International Nuclear Information System (INIS)

Basham, P.

2002-01-01

The complete IMS verification system for primary and auxiliary seismic together with that of radionuclide, hydroacoustic and infrasound is plotted on a global map and Africa in particular showing its status. IMS situation in East and Southern Africa is included

Malignancy-Induced Hypercalcemia—Diagnostic Challenges

Directory of Open Access Journals (Sweden)

Claire Hoyoux

2017-11-01

Full Text Available Hypercalcemia in children is a rare metabolic finding. The clinical picture is usually non-specific, and the etiology includes several entities (metabolic, nutritional, drug-induced, inflammatory, cancer-associated, or genetic depending on the age at presentation, but severe hypercalcemia is associated mainly with malignancy in childhood and sepsis in neonates. Severe parathyroid hormone (PTH-suppressed hypercalcemia is challenging and requires multidisciplinary diagnostic and therapeutic approaches to (i confirm or rule out a malignant cause, (ii treat it and its potentially dangerous complications. We report a case of severe and complicated PTH-independent hypercalcemia in a symptomatic 3-year-old boy. His age, severity of hypercalcemia and its complicated course, and the first imaging reports were suggestive of malignancy. The first bone and kidney biopsies and bone marrow aspiration were normal. The definitive diagnosis was a malignant-induced hypercalcemia, and we needed 4 weeks to assess other differential diagnoses and to confirm, on histopathological and immunochemical base, the malignant origin of hypercalcemia. Using this case as an illustrative example, we suggest a diagnostic approach that underlines the importance of repeated histology if the clinical suspicion is malignancy-induced hypercalcemia. Effective treatment is required acutely to restore calcium levels and to avoid complications.

Mistletoe in the treatment of malignant melanoma

Directory of Open Access Journals (Sweden)

Esin Sakallı Çetin

2014-03-01

Full Text Available Malignant melanoma is a malignant neoplasia drives from melanocytes. Malignant melanoma, the most causing death, is seen in the third place at skin cancer. Malignant melanoma shows intrinsic resistance to chemotherapeutic agents and variability in the course of the disease which are distinct features separating from other solid tumors. These features prevent the development and standardization of non-surgical treatment models of malignant melanoma. Although there is a large number of chemotherapeutic agents used in the treatment of metastatic malignant melanoma, it hasn’t been demonstrated the survival advantage of adjuvant treatment with chemotherapeutic agents. Because of the different clinical course of malignant melanoma, the disease is thought to be closely associated with immune system. Therefore, immunomodulatory therapy models were developed. Mistletoe stimulates the immune system by increasing the number and activity of dendritic cells, thus it has been shown to effect on tumor growth and metastasis of malignant melanoma patient. Outlined in this review are the recent developments in the understanding the role of mistletoe as a complementary therapy for malignant melanoma. J Clin Exp Invest 2014; 5 (1: 145-152

One decade of functional imaging in schizophrenia research. From visualisation of basic information processing steps to molecular brain imaging; Zehn Jahre funktionelle Magnetresonanztomographie in der Schizophrenieforschung. Von der Abbildung einfacher Informationsverarbeitungsprozesse zur molekulargenetisch orientierten Bildgebung

Energy Technology Data Exchange (ETDEWEB)

Tost, H. [Zentralinstitut fuer Seelische Gesundheit, NMR-Forschung in der Psychiatrie (Germany); Zentralinstitut fuer Seelische Gesundheit, NMR-Forschung in der Psychiatrie, Mannheim (Germany); Meyer-Lindenberg, A. [Genes, Neuroimaging Core Facility and Unit on Integrative Neuroimaging, Cognition and Psychosis Program, National Institute of Mental Health (United States); Ruf, M.; Demirakca, T.; Grimm, O.; Henn, F.A.; Ende, G. [Zentralinstitut fuer Seelische Gesundheit, NMR-Forschung in der Psychiatrie (Germany)

2005-02-01

Modern neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have contributed tremendously to our current understanding of psychiatric disorders in the context of functional, biochemical and microstructural alterations of the brain. Since the mid-nineties, functional MRI has provided major insights into the neurobiological correlates of signs and symptoms in schizophrenia. The current paper reviews important fMRI studies of the past decade in the domains of motor, visual, auditory, attentional and working memory function. Special emphasis is given to new methodological approaches, such as the visualisation of medication effects and the functional characterisation of risk genes. (orig.) [German] Bildgebende Verfahren wie die Magnetresonanz- und Positronenemissionstomographie haben entscheidend dazu beigetragen, dass psychiatrische Erkrankungen heutzutage im Kontext funktioneller, biochemischer und feinstruktureller Veraenderungen des Gehirns verstanden werden. Im Bereich der Schizophrenieforschung gibt insbesondere die funktionelle Magnetresonanztomographie seit Mitte der 90er-Jahre wichtige Einblicke in die neurobiologischen Grundlagen schizophrener Defizitbereiche. Die vorliegende Arbeit stellt die wichtigsten fMRT-Befunde der letzten Dekade in den Bereichen Psychomotorik, visuelle bzw. akustische Informationsverarbeitung, Aufmerksamkeit und Arbeitsgedaechtnis vor. Die Betrachtung erfolgt dabei unter der besonderen Beruecksichtigung aktueller methodischer Ansaetze wie der Darstellung von Therapieeffekten und der funktionellen Charakterisierung psychiatrischer Risikogene. (orig.)

Implementing Adaptive Educational Methods with IMS Learning Design

NARCIS (Netherlands)

Specht, Marcus; Burgos, Daniel

2006-01-01

Please, cite this publication as: Specht, M. & Burgos, D. (2006). Implementing Adaptive Educational Methods with IMS Learning Design. Proceedings of Adaptive Hypermedia. June, Dublin, Ireland. Retrieved June 30th, 2006, from http://dspace.learningnetworks.org

Multimedia als Entwicklungsfaktor im ländlichen Raum? : Fallbeispiel Wirtschaftsregion Friedrichshafen/Bodensee

OpenAIRE

Haupenthal, Edmund; Leuninger, Stefan; Beermann, Petra; Kutter, Martina

1998-01-01

Im Rahmen der vorliegenden empirischen Studie in der Wirtschaftsregion Friedrichshafen wurden die Wechselwirkungen zwischen regionalen Strukturfaktoren und „Multimedia-Entwicklungen“ im ländlichen Raum untersucht. Die positive Multimedia-Entwicklung geht auf folgende regionale Erfolgsfaktoren zurück: die politische Akzeptanz der neuen Technologie, die Vorhaltung der Multimedia-Akademie, die regionale Nachfrage, die Verfügbarkeit ausreichenden Know-hows und Humankapitals sowie das Vorhandensei...

RARE METASTASES OF MALIGNANT MELANOMA

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Marija Trenkić-Božinović

2014-09-01

Full Text Available Melanomas are malignant neoplasms that originate from melanocytes. The most common are on the skin and mucous membranes. Choroidal melanomas are quite different from cutaneous melanomas with regard to presentation, metastases, and treatment. We report two cases of metastatic gastric malignant melanoma of the eye and skin, with reference to the literature. The first patient was a woman aged 23 years, who underwent gastrectomy 22 months after enucleation of the eye due to malignant choroid melanoma. The second patient was a man, 72 years old, who underwent surgery 28 months before because of malignant melanoma of the skin of the forehead. Paraffin sections, 4 μm thick were stained using a classic method, as well as immunohistochemical DAKO APAAP method, using a specific S - 100 antibody and Melan A antibodies. The stomach is considered a rare place for the development of metastases. Metastases in the stomach are often limited to the submucosal as well as the serousmuscular layer, as noted in one of our patients. Metastatic melanoma of the gastrointestinal tract should be suspected in any patient with a history of malignant melanoma and new gastrointestinal symptoms. Because of the similarity between certain common histopathological types of malignant melanoma, primarily achromatic, and types of primary cancers of the stomach, the following immunohistochemical studies are needed: Melan A and S - 100 protein ( markers of malignant melanoma , as well as mucins: MUC5AC, MUC2 and CDX2 ( markers of different types of primary gastric carcinoma.

Emotionsregulationsstrategien und aggressives Verhalten im Kindergartenalter

OpenAIRE

Helmsen, Johanna; Petermann, Franz

2010-01-01

In der vorliegenden Studie (N = 193) wurde untersucht, ob sich körperlich und relational aggressive Kinder im Kindergartenalter (mittleres Alter: 55 Monate) in ihren Emotionsregulationsstrategien von ihren unauffälligen Altersgenossen unterscheiden. Zur Erhebung der Emotionsregulation wurde eine strukturierte, videografierte Verhaltensbeobachtung durchgeführt, in der gezielt Frustration ausgelöst wurde. Anschließend wurden Regulationsstrategien in sieben verschiedenen Kategorien ausgewertet. ...

STUDI KUALITATIF MENGENAI PERSEPSI DAN PERILAKU SEKSUAL WANITA PEKERJA SEKS KOMERSIAL (PSK DALAM UPAYA PENCEGAHAN IMS DI KOTA SEMARANG TAHUN 2012

Directory of Open Access Journals (Sweden)

Ratu Matahari

2015-04-01

Full Text Available Pendahuluan: Peningkatan jumlah kasus IMS di Kota Semarangdengan jumlah kasus IMS pada tahun 2009 tercatat mencapai 2.471 kasusdan jumlah kasus IMS pada tahun 2011 adalah 2473 kasus. Tujuan: Mendeskripsikan persepsi dan perilaku seksual wanita Pekerja Seks Komersial (PSK di Lokalisasi Sunan Kuning terhadap upaya pencegahan Infeksi Menular Seksual (IMS di Kota Semarang. Metode: Penelitian ini dilakukan dengan menggunakan teknik wawancara mendalam (indepth interview pada enam PSK yang mengalami IMS dan mewawancarai dua kelompok diskusi (FGD, seorang mucikari, dan seorang petugas lapangan (PL sebagai triangulasi. Analisis data menggunakan analisis isi (content analysis. Hasil: Pola Pengetahuan PSK dan persepsi PSK terhadap IMS juga sudah baik, tetapi perilaku PSK dalam upaya mencegah penularan IMS masih belum bisa dikatakan baik karena penggunaan kondom diantara pekerja seks komersial pada saat melakukan hubungan seksual dengan pelanggannya masih rendah. Tidak adanya dukungan dari mucikari dalam meningkatkan perilaku pencegahan IMS. Hal ini menunjukkan bahwa kepedulian terhadap kesehatan diri sendiri masih rendah. Kesimpulan: Perilaku pencegahan PSK terhadap penularan IMS belum baik. Perlu diadakan pelatihan dengan metode role playing kepada para PSK dan mucikari untuk meningkatkan kepedulian mereka terhadap kesehatan sehingga diharapkan akan terjadi perubahan perilaku baru dalam upaya pencegahan penularan IMS terhadap diri mereka sendiri atau pelanggan.  Kata kunci: Persepsi, pekerja seks komersial, IMS, Kota Semarang

Suchverhalten im Web: Empirische Ergebnisse

OpenAIRE

Schmidt-Mänz, Nadine

2005-01-01

Nadine Schmidt-Mänz vom Institut für Entscheidungstheorie u. Unternehmensforschung, Universität Karlsruhe, berichtete über „Suchverhalten im Web: Empirische Ergebnisse“. Rund 6000 Benutzer von Suchmaschinen füllten den von ihr hergestellten Online-Fragebogen aus. Einige ihrer Erkenntnisse: Als Suchmaschine wurde mit 91,3 % Google benutzt. Die Monopolstellung von Google war den Suchenden nicht bewußt. Einer der Schlüsse der Referentin: Es mangelt nicht an Suchmaschinen, sondern an der „Weitere...

Imaging in syndrome complex diabetes mellitus. Current standards and future perspectives; Bildgebung im Syndromkomplex Diabetes mellitus. Stellenwert und Chancen

Energy Technology Data Exchange (ETDEWEB)

Hetterich, H.; Schafnitzel, A. [Klinikum der Ludwig-Maximilians-Universitaet, Campus Grosshadern, Institut fuer Klinische Radiologie, Muenchen (Germany); Bamberg, F. [Eberhard-Karls-Universitaet, Abteilung fuer Diagnostische und Interventionelle Radiologie, Tuebingen (Germany)

2015-04-01

Evaluation von Folgeerkrankungen des Diabetes mellitus. Sie kommen u. a. bei der Evaluation der koronaren Herzerkrankung, peripheren arteriellen Verschlusserkrankung, Schlaganfall und diabetischem Fusssyndrom zum Einsatz. Technische Entwicklungen erlauben u. a. eine deutliche Dosisreduktion in der CT- sowie eine Beschleunigung von MRT-Untersuchungen und somit eine potenziell breite Anwendbarkeit radiologischer Verfahren. In Zukunft koennen insbesondere CT und MRT zur genaueren Frueherkennung von Komplikationen des Diabetes eingesetzt werden. Weitere interessante Einsatzgebiete sind Risikostratifizierungen, beispielsweise mittels Quantifizierung des Leberfettgehalts, oder Evaluation des Gefaesssystems mittels Ganzkoerper-MRT. Bevor diese Verfahren breit in der Patientenversorgung zum Einsatz kommen, sind eine nachweisliche Verbesserung von Ueberleben und Lebensqualitaet der Patienten sowie eine Beurteilung im Rahmen von Kosteneffektivitaetsstudien notwendig. Der Einsatz radiologischer Verfahren bei der Evaluation von Erkrankungen des Syndromkomplex Diabetes mellitus sollte gemaess aktueller Leitlinien erfolgen, besitzt aber aufgrund moeglicher neuer Indikationen ein hohes Potenzial. (orig.)

Qualitative Forschung mit lebenslimitierend erkrankten Kindern und Jugendlichen: Hören wir richtig hin?

Directory of Open Access Journals (Sweden)

Claudia Oetting-Roß

2016-05-01

Full Text Available Der nachfolgende Beitrag diskutiert die Herausforderungen des Einbezugs von betroffenen Kindern und Jugendlichen in die qualitative Forschung zum Thema lebenslimitierende Erkrankungen insbesondere unter dem Blickwinkel der methodischen Gestaltung dieses Einbezugs. Hierfür wird zunächst die Lebens- und Versorgungssituation lebenslimitierend erkrankter Kinder und Jugendlicher dargestellt. Anschließend werden Ergebnisse aus empirischen Studien erläutert und im Hinblick auf die Herausforderungen einer Beteiligung erkrankter Kinder, Jugendlicher und ihrer Familien diskutiert. Als Ergebnis dieser Analyse erfolgt eine Zusammenfassung zentraler Diskussionsstränge. Zudem werden Strategien für eine sensible Integration von schwerkranken Kindern und Jugendlichen abgeleitet und auf der Basis bestehender Erfahrungen aus qualitativen Studien konkretisiert. Vor dem Hintergrund einer laufenden Studie mit lebenslimitierend erkrankten Kindern liefert der Beitrag Anregungen für die methodische Planung, Durchführung und Evaluation von entsprechenden Forschungsvorhaben. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1602241

Simulants of malignant melanoma

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Gérald E. Piérard

2015-08-01

Full Text Available During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential. In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas, and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present.

Artroscopia del hombro: Técnica e imágenes

OpenAIRE

ARANGO GARCIA, GASTON; ALVAREZ CAMBRAS, RODRIGO; LOPEZ CABRERA, JOSE RAMON; MIRANDEZ OLARAN, HUGO; LARA VALDIVIA, JESUS

1995-01-01

En este trabajo se muestra cómo realizar la técnica de la artroscopia de la articulación del hombro. Se presentan vistas de las imágenes artroscópicas y de la anatomía normal de la articulación para ayudar a la interpretación e identificación de las imágenes patológicas más comúnmente encontradas. Se realizó la técnica en 8 pacientes, deportistas con hombros dolorosos, en los cuales el diagnóstico clínico no era certero. Este trabajo se realizó en 1990 para introducir la técnica artroscópica ...

Gynecologic Malignancies Post-LeFort Colpocleisis

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Rayan Elkattah

2014-01-01

Full Text Available Introduction. LeFort colpocleisis (LFC is a safe and effective obliterative surgical option for older women with advanced pelvic organ prolapse who no longer desire coital activity. A major disadvantage is the limited ability to evaluate for post-LFC gynecologic malignancies. Methods. We present the first case of endometrioid ovarian cancer diagnosed after LFC and review all reported gynecologic malignancies post-LFC in the English medical literature. Results. This is the second reported ovarian cancer post-LFC and the first of the endometrioid subtype. A total of nine other gynecologic malignancies post-LFC have been reported in the English medical literature. Conclusions. Gynecologic malignancies post-LFC are rare. We propose a simple 3-step strategy in evaluating post-LFC malignancies.

Systeme im Einsatz. Lernmanagement, Kompetenzmanagement und PLE

NARCIS (Netherlands)

Kalz, Marco; Schön, Sandra; Lindner, Martin; Roth, Detlev; Baumgartner, Peter

2011-01-01

Kalz, M., Schön, S., Lindner, M., Roth, D., & Baumgartner, P. (2011). Systeme im Einsatz. Lernmanagement, Kompetenzmanagement und PLE. In M. Ebner, & S. Schön (Eds.), L3T - Lerhbuch für Lernen und Lehren mit Technologie (pp. 111-118). Graz, Austria: Uni Graz. Available at

How IMS Enables Converged Services for Cable and 3G Technologies: A Survey

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Noël Crespi

2008-04-01

Full Text Available The IP multimedia subsystem (IMS is a service control overlay standardized by the 3GPP. The IMS is based on session initiation protocol (SIP to establish, modify, and terminate the sessions. It provides a clean separation between services, signaling, and media with the potential to enable control and management of services over multiple transport technologies. In the scope of fixed-mobile convergence, this paper is dedicated to presenting a review of how cable networks can be integrated into IMS technology to achieve 3G-cable horizontal convergence. Cable networks, as one of the major fixed broadband access technologies with PacketCable architecture, are able to provide broadband internet access and VoIP in addition to cable TV. In this article, we review the evolution in PacketCable architecture to take up IMS. In this way, we consider the standardization and research activities to address this integration. We review some important challenges such as SIP protocol compatibility, defining unique user profile, required enhancement in authentication process, QoS and charging system.

How IMS Enables Converged Services for Cable and 3G Technologies: A Survey

Directory of Open Access Journals (Sweden)

Mani Mehdi

2008-01-01

Full Text Available The IP multimedia subsystem (IMS is a service control overlay standardized by the 3GPP. The IMS is based on session initiation protocol (SIP to establish, modify, and terminate the sessions. It provides a clean separation between services, signaling, and media with the potential to enable control and management of services over multiple transport technologies. In the scope of fixed-mobile convergence, this paper is dedicated to presenting a review of how cable networks can be integrated into IMS technology to achieve 3G-cable horizontal convergence. Cable networks, as one of the major fixed broadband access technologies with PacketCable architecture, are able to provide broadband internet access and VoIP in addition to cable TV. In this article, we review the evolution in PacketCable architecture to take up IMS. In this way, we consider the standardization and research activities to address this integration. We review some important challenges such as SIP protocol compatibility, defining unique user profile, required enhancement in authentication process, QoS and charging system.

Evaluation of the Indian Migration Study Physical Activity Questionnaire (IMS-PAQ: a cross-sectional study

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Sullivan Ruth

2012-02-01

Full Text Available Abstract Background Socio-cultural differences for country-specific activities are rarely addressed in physical activity questionnaires. We examined the reliability and validity of the Indian Migration Study Physical Activity Questionnaire (IMS-PAQ in urban and rural groups in India. Methods A sub-sample of IMS participants (n = 479 was used to examine short term (≤1 month [n = 158] and long term (> 1 month [n = 321] IMS-PAQ reliability for levels of total, sedentary, light and moderate/vigorous activity (MVPA intensity using intraclass correlation (ICC and kappa coefficients (k. Criterion validity (n = 157 was examined by comparing the IMS-PAQ to a uniaxial accelerometer (ACC worn ≥4 days, via Spearman's rank correlations (ρ and k, using Bland-Altman plots to check for systematic bias. Construct validity (n = 7,000 was established using linear regression, comparing IMS-PAQ against theoretical constructs associated with physical activity (PA: BMI [kg/m2], percent body fat and pulse rate. Results IMS-PAQ reliability ranged from ICC 0.42-0.88 and k = 0.37-0.61 (≤1 month and ICC 0.26 to 0.62; kappa 0.17 to 0.45 (> 1 month. Criterion validity was ρ = 0.18-0.48; k = 0.08-0.34. Light activity was underestimated and MVPA consistently and substantially overestimated for the IMS-PAQ vs. the accelerometer. Criterion validity was moderate for total activity and MVPA. Reliability and validity were comparable for urban and rural participants but lower in women than men. Increasing time spent in total activity or MVPA, and decreasing time in sedentary activity were associated with decreasing BMI, percent body fat and pulse rate, thereby demonstrating construct validity. Conclusion IMS-PAQ reliability and validity is similar to comparable self-reported instruments. It is an appropriate tool for ranking PA of individuals in India. Some refinements may be required for sedentary populations and women in India.

Lysosomale Speicherkrankheiten

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Stulnig T

2011-01-01

Full Text Available Lysosomale Speicherkrankheiten sind eine klinisch und biochemisch heterogene Gruppe von genetischen Erkrankungen, die ihren Ursprung in einer Dysfunktion von lysosomalen Stoffwechselvorgängen haben. Lysosomale Speicherkrankheiten sind dramatisch unterdiagnostiziert, obwohl für eine ständig wachsende Anzahl der Erkrankungen wirksame Therapien zur Verfügung stehen. Klinisch manifestieren sich lysosomale Speicherkrankheiten mit neurologischen Störungen, skelettalen Veränderungen, Hepatosplenomegalie und kardiovaskulären Ereignissen und stellen damit wichtige Differenzialdiagnosen häufiger internistischer Erkrankungen dar. In dieser Übersicht wird die Pathophysiologie lysosomaler Speicherkrankheiten dargelegt und anhand besonders relevanter Beispiele (Mb. Gaucher, Mb. Fabry, Mb. Pompe auf ihre klinische Präsentation und Diagnostik eingegangen. Aktuell verfügbare Therapieoptionen und solche in fortgeschrittenen Entwicklungsstufen werden beschrieben.

An IMS-Based Middleware Solution for Energy-Efficient and Cost-Effective Mobile Multimedia Services

Science.gov (United States)

Bellavista, Paolo; Corradi, Antonio; Foschini, Luca

Mobile multimedia services have recently become of extreme industrial relevance due to the advances in both wireless client devices and multimedia communications. That has motivated important standardization efforts, such as the IP Multimedia Subsystem (IMS) to support session control, mobility, and interoperability in all-IP next generation networks. Notwithstanding the central role of IMS in novel mobile multimedia, the potential of IMS-based service composition for the development of new classes of ready-to-use, energy-efficient, and cost-effective services is still widely unexplored. The paper proposes an original solution for the dynamic and standard-compliant redirection of incoming voice calls towards WiFi-equipped smart phones. The primary design guideline is to reduce energy consumption and service costs for the final user by automatically switching from the 3G to the WiFi infrastructure whenever possible. The proposal is fully compliant with the IMS standard and exploits the recently released IMS presence service to update device location and current communication opportunities. The reported experimental results point out that our solution, in a simple way and with full compliance with state-of-the-art industrially-accepted standards, can significantly increase battery lifetime without negative effects on call initiation delay.

Antisemitismus, Shoah und deutsche Verantwortung:(Nach)Wirkungen des Nationalsozialismus im medialen Nahostdiskurs

OpenAIRE

Ullrich, Peter

2010-01-01

Wahrscheinlich wird kein anderer internationaler Konflikt derart kontrovers und emotional in der bundesrepublikanischen Öffentlichkeit sowie auch und gerade in der politischen Linken diskutiert wie der israelisch-palästinensische oder weiter gefasst, der Nahost-Konflikt. Aus diesem Grund nimmt dieses Thema einen besonderen Platz in der Bildungsarbeit der Rosa-Luxemburg- Stiftung im Inland wie im Ausland ein. Wenngleich dabei auch in der Stiftung und ihrem Umfeld die Meinungen auseinandergehen...

[About the signs of malignant pheochromocytoma].

Science.gov (United States)

Simonenko, V B; Makanin, M A; Dulin, P A; Vasilchenko, M I; Lesovik, V S

2012-01-01

Morphological criteria for malignant pheochromocytoma remain to be developed According to the WHO recommendations, the sole absolute criteria is the presence of metastases in the organs normally containing no chromaffin tissue. Such signs as cellular and nuclear polymorphism, mytotic activity, vascular invasion, capsular ingrowth are not sufficient to describe a pheochromocytoma as malignant. It is equally dfficult to differentiate between malignant and benign tumours based on histological data since histologically mature neoplasms can produce metastases. Based on the results of original studies, the authors believe that such histological features as vascular and capsular invasion do not necessarily suggest unfavourable prognosis. Therefore, the conclusion of malignancy based on such features can not be regarded as absolute. Probably such neoplasms should be called "pheochromocytomas with morphological signs of malignant growths". They should be referred to the tumours with uncertain malignancy potential based on the known discrepancy between morphological structure and biological activity of neoplasms. Comparative studies of clinical and morphological features of pheochromocytomas showed that their histological type (alveolar; solid, dyscomplexed, trabecular) and morphological signs of malignant growth influence both the clinical picture and arterial hypertension. There are no significant relationship between the above morphological signs, timour mass and clinical manifestations of pheochromocytomas.

Malignant salivary gland tumours

International Nuclear Information System (INIS)

Thompson, S.H.

1982-01-01

The most frequent malignant salivary gland tumours are the mucoepidermoid tumour, adenoid cystic carcinoma and adenocarcinoma. The major salivary glands and the minor glands of the mouth and upper respiratory tract may potentially develop any of these malignant lesions. Malignant lesions most frequently present as a palpable mass and tend to enlarge more rapidly than benign neoplasms. Pain, paresthesia, muscle paralysis and fixation to surrounding tissue are all ominous signs and symptoms. The only reliable means of differential diagnosis of these lesions is biopsy and histologic analysis. Therapy involves surgery or a combination of surgery and radiation therapy. The ultimate prognosis is governed by the intrinsic biologic behaviour of the neoplasms, the extent of disease and adequate clinical therapy

Malignant salivary gland tumours

Energy Technology Data Exchange (ETDEWEB)

Thompson, S.H. (University of the Witwatersrand, Johannesburg (South Africa). Dept. of Oral Pathology)

1982-08-01

The most frequent malignant salivary gland tumours are the mucoepidermoid tumour, adenoid cystic carcinoma and adenocarcinoma. The major salivary glands and the minor glands of the mouth and upper respiratory tract may potentially develop any of these malignant lesions. Malignant lesions most frequently present as a palpable mass and tend to enlarge more rapidly than benign neoplasms. Pain, paresthesia, muscle paralysis and fixation to surrounding tissue are all ominous signs and symptoms. The only reliable means of differential diagnosis of these lesions is biopsy and histologic analysis. Therapy involves surgery or a combination of surgery and radiation therapy. The ultimate prognosis is governed by the intrinsic biologic behaviour of the neoplasms, the extent of disease and adequate clinical therapy.

Coeliac disease, splenic function, and malignancy

OpenAIRE

Robertson, D A F; Swinson, C M; Hall, R; Losowsky, M S

1982-01-01

Blood films from 41 cases of coeliac disease complicated by malignancy were examined and evidence of hyposplenism found in 12 cases (29%). This is similar to the proportion of adult coeliacs without malignancy who have hypoplenism and it is concluded that impaired splenic function is not associated with the development of malignancy in coeliac disease.

MULTIPLE PRIMARY MALIGNANCIES IN PATIENTS.cdr

African Journals Online (AJOL)

RICHY

the youngest was 36 years old. Four of our patients were females. Two patients had cancers of the colon followed by ovarian malignancy in one and a rectal malignancy in the other. Of the other patients, one had cancer of the cervix and later she developed None Hodgkin's lymphoma. Two had bilateral breast malignancies.

Malignant external otitis: CT evaluation

International Nuclear Information System (INIS)

Curtin, H.D.; Wolfe, P.; May, M.

1982-01-01

Malignant external otitis is an aggressive infection caused by Pseudomonas aeruginosa that most often occurs in elderly diabetics. Malignant external otitis often spreads inferiorly from the external canal to involve the subtemporal area and progresses medially towards the petrous apex leading to multiple cranial nerve palsies. The computed tomographic (CT) findings in malignant external otitis include obliteration of the normal fat planes in the subtemporal area as well as patchy destruction of the bony cortex of the mastoid. The point of exit of the various cranial nerves can be identified on CT scans, and the extent of the inflammatory mass correlates well with the clinical findings. Four cases of malignant external otitis are presented. In each case CT provided a good demonstration of involvement of the soft tissues at the base of the skull

Medien im Lehramtsstudium für die Sekundarstufe in Österreich. Eine quantitativ-inhaltsanalytische Lehrplananalyse von vier Curricula.

Directory of Open Access Journals (Sweden)

Christian Swertz

2015-12-01

Full Text Available Medien sind für Erziehung und Unterricht notwendig sowie im Alltag, in der Politik und der Ökonomie relevant. Daher ist zu erwarten, dass Medien in den Curricula für die Lehramtsausbildung im Sekundarbereich vorkommen. Ob diese Erwartung zutrifft, wird an vier Curricula für den Sekundarbereich mit einem quantitativen inhaltsanalytischen Verfahren untersucht. Die Ergebnisse zeigen, dass Medien im Allgemeinen und Medienpädagogik, Medienkompetenz und Mediendidaktik im Besonderen nur selten vorkommen und die meisten der seltenen Vorkommnisse irrelevant sind.

Bilateral primary malignant lymphoma of the breast.

Science.gov (United States)

Shpitz, B; Witz, M; Kaufman, Z; Griffel, B; Manor, Y; Dinbar, A

1985-08-01

A rare case of bilateral primary malignant lymphoma of breast in a 76 year old woman is presented. The lesion was examined by electron microscopy and immunochemistry. The diagnosis of primary malignant lymphoma remains a diagnosis by exclusion and requires extensive work-up to exclude widespread malignant process. The behaviour of this malignancy tends to be an aggressive one and the prognosis is generally poor.

Image diagnosis of malignant mesothelioma

International Nuclear Information System (INIS)

Niimi, Akiko; Ueno, Keiko; Isobe, Yoshinori; Hirayama, Akira

1987-01-01

3 cases of malignant mesothelioma confirmed by pathological examination were reported. CT showed solid mass with moderate enhancement by contrast medium. CT appears to be a very useful tool to make a diagnosis of malignant mesothelioma. (author)

Percutaneous therapy of inoperable biliary stenoses and occlusions with a new self-expanding nitinol stent (SMART); Perkutane Therapie inoperabler maligner Stenosen und Verschluesse der Gallenwege mit einem neu entwickelten selbstexpandierbaren Nitinolstent (SMART)

Energy Technology Data Exchange (ETDEWEB)

Zorger, N.; Lenhart, M.; Strotzer, M.; Paetzel, C.; Hamer, O.; Feuerbach, S.; Link, J. [Regensburg Univ. (Germany). Inst. fuer Roentgendiagnostik

2002-10-01

Objective: To evaluate the treatment of malignant biliary stenoses and occlusions using a new stent. Methods: In a prospective study, 25 patients with malignant obstructive jaundice were treated with SMART stents. The handling and the quality of stent expansion were documented. Stent function was assessed 2-4 days after intervention by cholangiography and laboratory tests. A follow-up was performed three months, after stent placement. Results: All lesions were treated successfully, with a total of 35 stents implanted. In 14 patients a further balloon dilatation was performed after stent placement (8-10 mm diameter/40-80 mm length). The mean serum bilirubin level decreased significantly from 11.6 mg/dl to 4.6 mg/dl after intervention (p<0.05). The follow-up showed a mean serum bilirubin level at 4.0 mg/dl. In 4 cases (16%) a further intervention (PTCD or stent) was performed. Six patients died due to tumor progression. The stents proved to be patent in 79% (n=15) of patients alive at the time of follow-up. Conclusions: Placement of the SMART stent for the therapy of malignant biliary lesions yields good technical and clinical results. (orig.) [German] Zielsetzung: Evaluation der technischen Handhabung und Effizienz eines neu entwickelten Stents zur Therapie maligner Gallenwegsstenosen und Verschluesse. Material und Methodik: In einer prospektiven Studie wurden 25 Patienten mit Verschlussikterus bei maligner Gallengangsstenose palliativ mit dem SMART {sup trademark} -Stent behandelt. Evaluiert wurden die Handhabung des Stents und die Qualitaet der Stententfaltung. Die Stentfunktion wurde nach 2-4 Tagen ueber eine liegende interne/externe Drainage cholangiographisch sowie anhand des Verlaufs der Laborparameter kontrolliert. Eine zusaetzliche Kontrolle der Stentfunktion erfolgte nach drei Monaten. Dabei wurden das subjektive Wohlbefinden des Patienten, der aktuelle Gesamtbilirubinspiegel im Serum und die Anzahl weiterer, im Nachsorgezeitraum durchgefuehrter

La política de las imágenes en Jacques Rancière

OpenAIRE

Corella Lacasa, Miguel

2011-01-01

Someto hoy a discusión la crónica de mi particular recorrido fragmentario e inacabado por la obra de Rancière, que organizaré a partir algunas de las imágenes que, en mi opinión, juegan un papel importante en su argumenta ción. Espero que este álbum de imágenes y el discurso tramado a partir de ellas puedan ser de alguna utilidad para el debate acerca del sentido o el uso político de las imágenes y, más en general, para la discusión de las relaciones entre estética y po...

Veränderungen der Serumlipide bei Senioren im Verlauf des Alterns unter Berücksichtigung ausgewählter Einflussfaktoren : eine Untersuchung im Rahmen der Gießener Senioren Langzeitstudie

OpenAIRE

Richter, Margrit

2014-01-01

In der vorliegenden Arbeit wurde im Rahmen der Giessener Senioren Langzeitstudie (GISELA) untersucht, ob und in wie weit sich die Konzentrationen der Serumlipide (Gesamtcholesterol (TC), HDL-Cholesterol (HDL-C), LDL-Cholesterol (LDL-C), NonHDL-Cholesterol (NonHDL-C) und Triglyceride (TG)) im Verlauf fortgeschrittenen Alterns verändern. Dabei wurden folgende mögliche Einflussfaktoren berücksichtigt: BMI, WHR, PAI, Fettmasse, Kohlenhydrat¬zufuhr, Ballaststoffzufuhr, Zufuhr mehrfach ungesättigte...

Malignent diseases in childhood

International Nuclear Information System (INIS)

Havers, W.

1980-01-01

As malignant diseases in childhood are rare, and only a small group of radiotherapists have been able to gain experience in this field, this chapter treats the particularities of childhood from this aspect. The side effects of radiotherapy are particularly important here for the growing and developing organism of the child. The most frequently occuring malignant diseases are treated individually. (MG) [de

Datamart use for complex data retrieval in an ArcIMS application

Energy Technology Data Exchange (ETDEWEB)

Scherma, S. (Steven); Bolivar, Stephen L.

2004-01-01

This paper describes the use of datamarts and data warehousing concepts to expedite retrieval and display of complex attribute data from multi-million record databases. Los Alamos National Laboratory has developed an Internet application (SMART) using ArcIMS that relies on datamarts to quickly retrieve attribute data, associated with, but not contained within GIS layers. The volume of data and the complex relationships within the transactional database made data display within ArcIMS impractical without the use of datamarts. The technical issues and solutions involved in the development are discussed.

Erstellung einer Checkliste zur Beurteilung des Arbeitsplatzes eines Physiotherapeuten nach ergonomischen Gesichtspunkten

OpenAIRE

Gauermann, Christoph

2013-01-01

Einleitung: Arbeitsbedingte Erkrankungen des Muskel-Skelett-Systems sind unter Physiotherapeuten sehr häufig. Die präventive Forschung hat diese Berufsgruppe bisher kaum untersucht. In diesem Zusammenhang stellt die Veränderung des Arbeitsumfeldes einen vielversprechenden Ansatz für die Verhinderung arbeitsbedingter Erkrankungen dar. Das Ziel dieser Arbeit ist die Erstellung einer Checkliste zur Bewertung des Arbeitsplatzes eines Physiotherapeuten zu erstellen. Material und Methoden: ...

Identification of Candida albicans by using different culture medias and its association in potentially malignant and malignant lesions.

Science.gov (United States)

Saigal, Sonal; Bhargava, Ankur; Mehra, S K; Dakwala, Falguni

2011-07-01

The present study evaluates the association of Candida albicans with normal control group, potentially malignant and malignant lesions of oral cavity by using two different liquid culture media. Saliva was collected and biopsy was taken only from those clinically suspected potentially malignant and malignant lesions for histopathological diagnosis. Saliva samples were inoculated for fungal growth in Sabouraud's dextrose agar and culture-positive samples had undergone for Germ tube test. Germ tube-positive samples were further taken for quantification of chlamydospore production in liquid media at 8 and 16 hours. In normal control groups no fungus growth was found; however, potentially malignant and malignant cases showed fungus growth, positive germ tube test and chlamydospore formation. The result also showed rapid and quantitatively more chlamydospore formation in corn meal broth + 5% milk in comparison to serum milk culture media. The oral mucosa is compromised in potentially malignant lesions, it can be argued that this species may be involved in carcinogenesis by elaborating the nitrosamine compounds which either act directly on oral mucosa or interact with other chemical carcinogens to activate specific proto-oncogenes and thereby initiate oral neoplasia.

Identification of Candida albicans by using different culture medias and its association in potentially malignant and malignant lesions

Directory of Open Access Journals (Sweden)

Sonal Saigal

2011-01-01

Full Text Available Background and Objective: The present study evaluates the association of Candida albicans with normal control group, potentially malignant and malignant lesions of oral cavity by using two different liquid culture media. Materials and Methods: Saliva was collected and biopsy was taken only from those clinically suspected potentially malignant and malignant lesions for histopathological diagnosis. Saliva samples were inoculated for fungal growth in Sabouraud′s dextrose agar and culture-positive samples had undergone for Germ tube test. Germ tube-positive samples were further taken for quantification of chlamydospore production in liquid media at 8 and 16 hours. Results: In normal control groups no fungus growth was found; however, potentially malignant and malignant cases showed fungus growth, positive germ tube test and chlamydospore formation. The result also showed rapid and quantitatively more chlamydospore formation in corn meal broth + 5% milk in comparison to serum milk culture media. Conclusion: The oral mucosa is compromised in potentially malignant lesions, it can be argued that this species may be involved in carcinogenesis by elaborating the nitrosamine compounds which either act directly on oral mucosa or interact with other chemical carcinogens to activate specific proto-oncogenes and thereby initiate oral neoplasia.

Security in the internet; Sicherheitsaspekte im Internet

Energy Technology Data Exchange (ETDEWEB)

Seibel, R.M.M.; Kocher, K.; Landsberg, P. [Witten-Herdecke Univ., Witten (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie

2000-04-01

Aim of the study: Is it possible to use the Internet as a secure media for transport of telemedicine? Which risks exist for routine use? In this article state of the art methods of security were analysed. Telemedicine in the Internet has severe risks, because patient data and hospital data of a secure Intranet can be manipulated by connecting it to the Web. Conclusions: Establishing of a firewall and the introduction of HPC (Health Professional Card) are minimizing the risk of un-authorized access to the hospital server. HPC allows good safety with digital signature and authentication of host and client of medical data. For secure e-mail PGP (Pretty Good Privacy) is easy to use as a standard protocol. Planning all activities exactly as well as following legal regulations are important requisites for reduction of safety risks in Internet. (orig.) [German] Ziele der Studie und Analyse: Es sollten die Fragen beantwortet werden, ob es moeglich ist, das Internet als sicheres Uebermittlungsmedium fuer Telemedizin zu nutzen und welche Sicherheitsrisiken bestehen. Dazu wurden die gaengigen Sicherheitsmethoden analysiert. Telemedizin im Internet ist mit Sicherheitsrisiken behaftet, die durch die Oeffnung eines Intranets mit der Moeglichkeit zur unberechtigten Manipulation von aussen bedingt sind. Schlussfolgerung: Diese Sicherheitsrisiken koennen durch eine Firewall weitgehend unterbunden werden. Chipkarten wie die Health professional card ermoeglichen eine hohe Sicherheit bei digitaler Signatur und sicherer Authentifikation der Sender und Empfaenger von Daten im Internet. Auch Standards wie Pretty good privacy sind inzwischen fuer sichere e-mails einfach einzusetzen. Wichtige Voraussetzung fuer die Reduktion von Sicherheitsrisiken ist unter Beruecksichtigung der gesetzlichen Vorgaben die exakte Planung aller Aktivitaeten im Internet, bei denen medizinische Patientendaten versandt werden sollen, in einem Team aus Aerzten und Informatikern. (orig.)

Dynamik des Kaufverhaltens im Bio-Sortiment

OpenAIRE

Buder, Fabian; Hamm, Ulrich; Bickel, Malte; Bien, Barbara; Michels, Paul

2010-01-01

Das Gesamtziel des vorliegenden Forschungsprojekts war es, eine detaillierte Informationsgrundlage zum tatsächlichen Kaufverhalten von deutschen Haushalten bei ökologischen Lebensmitteln auf der Basis von Haushaltspaneldaten zu erstellen. Dazu sollten zum einen relevante Aspekte des Kaufverhaltens von Haushalten bei Öko-Lebensmitteln im Zeitverlauf von 2004 bis 2008 analysiert und zum anderen die Einflussfaktoren des Kaufverhaltens bei Öko-Lebensmitteln für das Jahr 2008 identifiziert werden....

Gewerbsmässigkeit im schweizerischen Luftrecht

OpenAIRE

Müller, Roland

2005-01-01

Der Begriff der Gewerbsmässigkeit hat im schweizerischen Luftrecht eine grosse Bedeutung. Werden gewerbsmässige Flüge ohne die entsprechenden Bewilligungen und Voraussetzungen durchgeführt, so resultieren gravierende zivilrechtliche, strafrechtliche und administrative Konsequenzen. In den massgebenden internationalen Luftfahrtabkommen findet sich keine Definition der Gewerbsmässigkeit, dies wird den einzelnen Staaten überlassen. Nur in den Joint Aviation Requirements und in der EU-Zollver...

[Malignant pheochromocytoma].

Science.gov (United States)

Mornex, R; Berthezene, F; Peyrin, L; Tran Minh, V; Martin, J P; Fulchiron, D

1979-11-01

The reported incidence of malignant pheochromocytoma varies from series to series. In this series 4 cases (7.2 p. 100) were observed out of a total of 55. In two cases the tumour progressed rapidly but in the other two cases, metastases were detected 3 to 12 years after the apparent cure of a histologically benign pheochromocytoma. The urinary levels of catecholamines and their metabolites gave no indication of the underlying malignancy. The diagnosis was only made from the clinical and radiological detection of metastases (2 hepatic, 2 bone). There is no satisfactory treatment and various therapeutic methods have to be used in succession; surgery for a single metastasis, radiotherapy and antiadrenergic agents to combat clinical manifestations. The natural history of this tumour is relatively long.

Radiofrequency ablation of liver metastases; Radiofrequenzablation von Lebermetastasen

Energy Technology Data Exchange (ETDEWEB)

Pereira, P.L.; Clasen, S.; Schmidt, D.; Wiskirchen, J.; Tepe, G.; Claussen, C.D. [Abt. fuer Radiologische Diagnostik, Eberhard-Karls-Univ. Tuebingen (Germany); Boss, A. [Abt. fuer Radiologische Diagnostik, Eberhard-Karls-Univ. Tuebingen (Germany); Sektion fuer Experimentelle Radiologie der Abt. fuer Radiologische Diagnostik, Eberhard-Karls-Univ. Tuebingen (Germany); Gouttefangeas, C. [Abt. Immunologie des Inst. fuer Zellbiologie, Eberhard-Karls-Univ. Tuebingen (Germany); Burkart, C. [Zentrum fuer gastroenterologische Onkologie der Medizinischen Klinik, Eberhard-Karls-Univ. Tuebingen (Germany)

2004-04-01

The liver is the second only to lymph nodes as the most common site of metastatic disease irrespective of the primary tumor. Up to 50% of all patients with malignant diseases will develop liver metastases with a significant morbidity and mortality. Although the surgical resection leads to an improvement of the survival time, only approximately 20% of the patients are eligible for surgical intervention. Radiofrequency (RF) ablation represents one of the most important alternatives as well as complementary methods for the therapy of liver metastases. RF ablation can lead in a selected patient group to a palliation or to an increased life expectancy. RF ablation appears either safer (vs. cryotherapy) or easier (vs. laser) or more effective (percutaneous ethanol instillation [PEI]), transarterial chemoembolisation [TACE] in comparison with other minimal invasive procedures. RF ablation can be performed percutaneously, laparoscopically or intraoperatively and may be combined with chemotherapy as well as with surgical resection. Permanent technical improvements of RF systems, a better understanding of the underlying electrophysiological principles and an interdisciplinary approach will lead to a prognosis improvement in patients with liver metastases. (orig.) [German] Die Leber ist unabhaengig vom Primaertumor nach den Lymphknoten die zweithaeufigste Lokalisation von Metastasen. Bis zu 50% aller Patienten mit malignen Erkrankungen werden im Verlauf ihrer Erkrankung Lebermetastasen entwickeln, die mit einer signifikanten Morbiditaet und Mortalitaet verbunden sind. Obwohl die chirurgische Resektion zu einer verlaengerten Ueberlebenszeit fuehrt, sind nur ca. 20% der Patienten fuer einen chirurgischen Eingriff geeignet. Die Radiofrequenz-(RF-)Ablation stellt derzeit eine der effektivsten Alternativen und komplementaeren Methoden bei der Therapie von Lebermetastasen dar. In einem selektierten Patientengut fuehrt die RF-Ablation ueber den palliativen Einsatz hinaus zu einer

ImBuild: Impact of building energy efficiency programs

Energy Technology Data Exchange (ETDEWEB)

Scott, M.J.; Hostick, D.J.; Belzer, D.B.

1998-04-01

As part of measuring the impact of government programs on improving the energy efficiency of the Nation`s building stock, the Department of Energy Office of Building Technology, State and Community Programs (BTS) is interested in assessing the economic impacts of its portfolio of programs, specifically the potential impact on national employment and income. The special-purpose version of the IMPLAN model used in this study is called ImBuild. In comparison with simple economic multiplier approaches, such as Department of Commerce RIMS 2 system, ImBuild allows for more complete and automated analysis of the economic impacts of energy efficiency investments in buildings. ImBuild is also easier to use than existing macroeconomic simulation models. The authors conducted an analysis of three sample BTS energy programs: the residential generator-absorber heat exchange gas heat pump (GAX heat pump), the low power sulfur lamp (LPSL) in residential and commercial applications, and the Building America program. The GAX heat pump would address the market for the high-efficiency residential combined heating and cooling systems. The LPSL would replace some highly efficient fluorescent commercial lighting. Building America seeks to improve the energy efficiency of new factory-built, modular, manufactured, and small-volume, site-built homes through use of systems engineering concepts and early incorporation of new products and processes, and by increasing the demand for more energy-efficient homes. The authors analyze a scenario for market penetration of each of these technologies devised for BTS programs reported in the BTS GPRA Metrics Estimates, FY99 Budget Request, December 19, 1997. 46 figs., 4 tabs.

Die nonverbale Kommunikation im Bundestagswahlkampf 2002:Gerhard Schröder versus Edmund Stoiber

OpenAIRE

Dieball, W. (Werner)

2004-01-01

Diese interdisziplinäre Dissertation aus dem Fachbereich Politikwissenschaften verfolgt vordergründig das Ziel, die Wirkungsweise der nonverbalen Kommunikation im Bundestagswahlkampf 2002 zu analysieren. Im Zentrum der empirisch-analytischen Untersuchung stehen Gerhard Schröder und Edmund Stoiber, die nach den nonverbalen Merkmalen: äußeres Erscheinungsbild, Mimik, Stimmklang, Gestik und Motorik untersucht werden. Das leitende Forschungsinteresse der Arbeit besteht darin, zu eruieren, inwiewe...

Malign katatoni, et neuropsykiatrisk syndrom

DEFF Research Database (Denmark)

Moltke, Katinka; Lublin, Henrik

2010-01-01

This case report describes a 36-year-old schizophrenic man who developed malignant catatonia during a hospital stay. He was treated with benzodiazepines (BZD) and 26 sessions of electroconvulsive therapy (ECT). After the therapy his condition normalised. Malignant catatonia is a rare condition...

Was bedeutet Trägheit? Begriff und Wirkung der Trägheit im Rahmen des Wechselverhaltens von Konsumenten im Strommarkt

NARCIS (Netherlands)

Henseler, Jörg

2006-01-01

In Wissenschaft und Praxis wird die Trägheit der Konsumenten als Ursache der geringen Wechselrate im deutschen Strommarkt für Haushaltskunden diskutiert. Der vorliegende Beitrag arbeitet heraus, dass es sich bei dieser Argumentation entweder um eine Tautologie oder ein Synomym für den Verbleib in

Miniature GC-Minicell Ion Mobility Spectrometer (IMS) for In Situ Measurements in Astrobiology Planetary Missions

Science.gov (United States)

Kojiro, Daniel R.; Stimac, Robert M.; Kaye, William J.; Holland, Paul M.; Takeuchi, Norishige

2006-01-01

Astrobiology flight experiments require highly sensitive instrumentation for in situ analysis of volatile chemical species and minerals present in the atmospheres and surfaces of planets, moons, and asteroids. The complex mixtures encountered place a heavy burden on the analytical instrumentation to detect and identify all species present. The use of land rovers and balloon aero-rovers place additional emphasis on miniaturization of the analytical instrumentation. In addition, smaller instruments, using tiny amounts of consumables, allow the use of more instrumentation and/or ionger mission life for stationary landers/laboratories. The miniCometary Ice and Dust Experiment (miniCIDEX), which combined Gas Chromatography (GC) with helium Ion Mobility Spectrometry (IMS), was capable of providing the wide range of analytical information required for Astrobiology missions. The IMS used here was based on the PCP model 111 IMS. A similar system, the Titan Ice and Dust Experiment (TIDE), was proposed as part of the Titan Orbiter Aerorover Mission (TOAM). Newer GC systems employing Micro Electro- Mechanical System (MEMS) based technology have greatly reduced both the size and resource requirements for space GCs. These smaller GCs, as well as the continuing miniaturization of Astrobiology analytical instruments in general, has highlighted the need for smaller, dry helium IMS systems. We describe here the development of a miniature, MEMS GC-IMS system (MEMS GC developed by Thorleaf Research Inc.), employing the MiniCell Ion Mobility Spectrometer (IMS), from Ion Applications Inc., developed through NASA's Astrobiology Science and Technology Instrument Development (ASTID) Program and NASA s Small Business Innovative Research (SBIR) Program.

Die filmstilistische Darstellung von Klaras Gehbehinderung im Kinderfilm "Heidi"

Directory of Open Access Journals (Sweden)

Maria Ohrfandl

2016-09-01

Full Text Available Dieser Beitrag soll die Forschungslücke zur Darstellung von Behinderungen speziell im Kinderfilm im deutschsprachigen Raum füllen. Auf Basis einer neoformalistisch orientierten Filmanalyse nach Bordwell und Thompson (2008, wird anhand von drei Filmsequenzen eine mögliche Lesart des Kinderfilms "Heidi" (Marcus 2005 entwickelt, um die filmstilistische Darstellung der Gehbehinderung des Mädchens Klara zu untersuchen. Die Ergebnisse werden mit theoretischen Überlegungen zur Problematik der Begriffsbestimmung von Körperbehinderung sowie zur Mobilität und Selbstbestimmung von Menschen mit Körperbehinderungen in Bezug gesetzt. Dabei zeigt sich im Wesentlichen, dass im Kinderfilm "Heidi" (Marcus 2005 Klaras Gehbehinderung als 'heilbare Krankheit' und der Rollstuhl als Einschränkung von Mobilität begriffen wird. Außerdem unterliegt Klara aufgrund ihrer Körperbehinderung überwiegend der Fremdbestimmung von Erwachsenen. Zur Klärung wahrscheinlicher filmischer Bildungspotenziale werden die Ergebnisse schließlich anhand der von Jörissen und Marotzki (2009 entwickelten Orientierungsdimensionen "Wissens-, Handlungs-, Grenz- und Biographiebezug" diskutiert. This article aims to bridge a knowledge gap by showing ways of representing disabilities in the German children film genre. Using Bordwell and Thomson's (2008 neoformalistically orientated film analysis approach, the movie "Heidi" (Marcus 2005 is analysed. Bordwell and Thompson's (2008 method is applied to three sequences of "Heidi" in order to present an interpretation and to discuss the representation of Clara's walking impediment. The results are then associated with theoretical considerations regarding the mobility and self-determination of people with disabilities and problematic definitions of the term 'physical disability'. It is shown that characters in the children's film "Heidi" (Marcus 2005 regard Clara's walking impediment as a 'curable disease' and the wheelchair as a limitation

Die Rule of Law im Völker- und im Europarecht – aktuelle Probleme. Gegenwärtige Herausforderungen und Chancen für die EU als eine "Union des Rechts"

Directory of Open Access Journals (Sweden)

Andreas J. Kumin

2015-10-01

Full Text Available Bei diesem für die Schriftfassung geringfügig adaptierten Artikel handelt es sich um die am 5. März 2015 in Graz gehaltene Antrittsvorlesung eines Praxisprofessors, der im Hauptberuf Leiter der Abteilung für Europarecht im Völkerrechtsbüro des österreichischen Außenministeriums ist. Im Anschluss an den Beitrag von Helmut Tichy (in ALJ 1/2015, 176–185, der sich auf das Völkerrecht und die internationalen Beziehungen konzentriert, setzt sich der vorliegende Artikel mit aktuellen Herausforderungen und Chancen der EU als „Union des Rechts“ auseinander. Dabei wird auf die Stärkung der Wahrung der Grundwerte und Rechtsstaatlichkeit in den EU-Mitgliedstaaten, den EU-Beitritt zur Europäischen Menschenrechtskonvention, die Sicherung einer wirksamen und leistungsfähigen EU-Gerichtsbarkeit sowie die Gewährleistung einer angemessenen demokratischen Mitbestimmung auf allen Stufen der Rechtsetzung eingegangen.

Paediatric Malignancies | Joseph | African Journal of Paediatric ...

African Journals Online (AJOL)

malignancies. Other common malignancies included sarcomas 10(14.71%), neurofibromatosis 9(13.24%), nephroblastoma 8(11.77%), acute lymphoblastic leukaemia 5(7.35%) and retinoblastoma 4(5.88%). The less common paediatric malignancies were melanoma, invasive lobular breast carcinoma and squamous cell ...

[Preussen und Livland im Zeichen der Reformation] / Anti Selart

Index Scriptorium Estoniae

Selart, Anti, 1973-

2015-01-01

Arvustus: Preussen und Livland im Zeichen der Reformation. Hrsg. von Arno Mentzel-Reuters und Klaus Neitmann. (Tagungsberichte der Historischen Kommission für ost- und westpreussische Landesforschung, 28). Fibre Verlag. Osnabrück 2014

[Bernt Ahrenholz : Verweise mit Demonstrativa im Gesprochenen Deutsch...] / Klaus Geyer

Index Scriptorium Estoniae

Geyer, Klaus

2008-01-01

Arvustus: Ahrenholz, Bernt. Verweise mit Demonstrativa im gesprochenen Deutsch : Grammatik, Zweitspracherwerb und Deutsch als Fremdsprache. Berlin ; New York : de Gruyter, 2007. (Linguistik - Impulse & Tendenzen ; 17)

Malignant priapism: a case report.

LENUS (Irish Health Repository)

Ellanti, P

2011-12-01

Metastatic involvement of the penis is most commonly from a primary malignant genitourinary tumour. It is a rare phenomenon usually reflecting disseminated malignancy associated with a poor prognosis. Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease.

Geschichtsbezogene und rechtspolitische Polonica im Bücherbestand Gottfried Lengnichs

Directory of Open Access Journals (Sweden)

Iwona Imańska

2017-11-01

Full Text Available Gottfried Lengnich, der Historiker und Syndikus der Stadt Danzig aus dem 18. Jahrhundert, hinterließ eine Büchersammlung mit über viertausend Büchern, die nach seinem Tode in zwei Auktionen im Juli und November 1774 versteigert werden sollten. Die Auktionskataloge befinden sich in der Staatsbibliothek zu Berlin – Stiftung Preußischer Kulturbesitz und sind auch online zugänglich. Wegen wissenschaftlicher Interessen Lengnichs befanden sich in seiner Bibliothek ca. 600 Polonica-Drucke, die meisten davon waren Abhandlungen im Themenfeld Geschichte, Recht und Politik. Die Analyse dieses Fragments des Bücherbestands Lengnichs bewies, dass der Syndikus eine perfekte Arbeitswerkstatt für sich schuf, indem er die Werke der meisten wichtigsten polnischen und fremden Autoren, die über die Geschichte und die Gesetzgebung Polens und Preußens schrieben, sammelte.

Compresión de imágenes médicas

Directory of Open Access Journals (Sweden)

Tatiana Noreña

2013-03-01

Full Text Available La medicina moderna es una actividad cada vez más compleja, basada en la información proveniente de múltiples fuentes: historias clínicas, dictáfonos e imágenes y vídeos provenientes de múltiples dispositivos. Las imágenes médicas constituyen una de las fuentes de mayor importancia, por cuanto ofrecen un apoyo integral del acto médico: el diagnóstico y el seguimiento. Sin embargo, la cantidad de información generada por los dispositivos de adquisición de imágenes sobrepasa rápidamente la disponibilidad de almacenamiento que tienen los servicios de radiología, lo cual genera costos adicionales en equipos de cómputo con mayor capacidad de almacenamiento. Además, la tendencia actual de desarrollo de aplicaciones en la “nube de cómputo”, tiene limitaciones por cuanto, aunque el almacenamiento es virtual y está disponible desde cualquier sitio, la conexión se hace a través de internet. En estos dos casos, el uso óptimo de la información requiere necesariamente de algoritmos de compresión potentes y adaptados a las necesidades de la actividad médica. En este artículo se presenta una revisión de las técnicas de compresión más utilizadas para el almacenamiento de imágenes, así como un análisis crítico de éstas desde el punto de vista de su uso en ambientes clínicos.   doi: http://dx.doi.org/10.7705/biomedica.v33i1.804

C-reactive protein and serum amyloid A levels in discriminating malignant from non-malignant pleural effusion

Directory of Open Access Journals (Sweden)

Hala Mohamed Shalaby Samaha

2015-10-01

Conclusion: Measurement of SAA and CRP levels in pleural fluid has good diagnostic utility in differentiation between malignant and non-malignant pleural effusion and pleural SAA has a better diagnostic performance than CRP.

Confidence in the use of information management and technology (IM and T) in radiography: Is age a barrier?

Energy Technology Data Exchange (ETDEWEB)

Rogers, Hywel, E-mail: rogershj1@cf.ac.u [Department of Radiography, School of Healthcare Studies, Cardiff University, Heath Park, Cardiff, CF14 4XN (United Kingdom); Pratt, Shaaron; Brown, Paul; Gambling, Tina [Department of Radiography, School of Healthcare Studies, Cardiff University, Heath Park, Cardiff, CF14 4XN (United Kingdom)

2010-08-15

Introduction: Age has been reported as a barrier to the use of Information Management and Technology (IM and T). Radiographers' confidence and ability in IM and T may be related to age and it is the aim of this research to investigate this relationship. Method: An online survey method gathered views from the radiographic population, between 31st August 2008 and 10th October 2008. The questionnaire encompassed IM and T ability, work based IM and T usage, personal IM and T usage, security and governance issues, education and training experience, the future and demographic details. For the purpose of this paper the first three sections and demographic section were considered. Results: Radiographers showed a good level of ability and confidence in the use of IM and T. Some general applications such as word processing showed a decreased confidence with age. Confidence in all radiography specific applications was scored highly although confidence in the use of Hospital Information Systems (HIS) and radiotherapy Treatment Planning Systems (TPS) showed the least confidence. Statistical analysis did not reveal a strong link between age and confidence in all applications. Discussion: While a link between age and confidence was not found in this study, frequency of use and training in IM and T require further investigation in relation to specific roles.

Confidence in the use of information management and technology (IM and T) in radiography: Is age a barrier?

International Nuclear Information System (INIS)

Rogers, Hywel; Pratt, Shaaron; Brown, Paul; Gambling, Tina

2010-01-01

Introduction: Age has been reported as a barrier to the use of Information Management and Technology (IM and T). Radiographers' confidence and ability in IM and T may be related to age and it is the aim of this research to investigate this relationship. Method: An online survey method gathered views from the radiographic population, between 31st August 2008 and 10th October 2008. The questionnaire encompassed IM and T ability, work based IM and T usage, personal IM and T usage, security and governance issues, education and training experience, the future and demographic details. For the purpose of this paper the first three sections and demographic section were considered. Results: Radiographers showed a good level of ability and confidence in the use of IM and T. Some general applications such as word processing showed a decreased confidence with age. Confidence in all radiography specific applications was scored highly although confidence in the use of Hospital Information Systems (HIS) and radiotherapy Treatment Planning Systems (TPS) showed the least confidence. Statistical analysis did not reveal a strong link between age and confidence in all applications. Discussion: While a link between age and confidence was not found in this study, frequency of use and training in IM and T require further investigation in relation to specific roles.

Computer-Aided Teaching Using MATLAB/Simulink for Enhancing an IM Course With Laboratory Tests

Science.gov (United States)

Bentounsi, A.; Djeghloud, H.; Benalla, H.; Birem, T.; Amiar, H.

2011-01-01

This paper describes an automatic procedure using MATLAB software to plot the circle diagram for two induction motors (IMs), with wound and squirrel-cage rotors, from no-load and blocked-rotor tests. The advantage of this approach is that it avoids the need for a direct load test in predetermining the IM characteristics under reduced power.…

Light-weight internet protocol multimedia subsystem (IMS) client: development for smart mobile devices

CSIR Research Space (South Africa)

Masonta, M

2010-11-01

Full Text Available : IP multimedia Services Identity Module J2ME: Java 2 Micro-Edition JCP: Java Community Process JSR: Java Specification Request MAGNET: My personal Adaptive Global Network MGCF: Media Gateway Control Function MIDP: Mobile Information Device...) .................................................................. 30 Figure 2.15: IMS-Communicator Screenshot (PT Inova??o, 2007) .......................................... 31 Figure 2.16: UCT IMS Client Screenshot (Waiting & Good, 2007) ......................................... 32 Figure 3.1: Sun Java WTK 2...

Computed tomography findings of malignant pleural mesothelioma

Energy Technology Data Exchange (ETDEWEB)

Shiota, Yutaro; Sato, Toshio; Yamaguchi, Kazuo; Ono, Tetsuya; Kaji, Masaro; Niiya, Harutaka (Kure Kyosai Hospital, Hiroshima (Japan))

1994-04-01

Computed tomography (CT) findings were assessed in 7 patients with malignant mesothelioma. CT findings were also reviewed in 9 patients with lung cancer and pleuritis carcinomatosa and in 11 patients with tuberculous pleuritis. Five patients with malignant mesothelioma underwent CT scans twice, on admission and from 1 to 7 months after admission. Tuberculous pleuritis could be distinguished from pleuritis carcinomatosa and malignant mesothelioma by the presence or absence of pleural nodularity and chest wall invasion. Although it was difficult to identify specific CT features clearly distinguishing malignant mesothelioma from pleuritis carcinomatosa, characteristic findings of malignant mesothelioma appeared to include the rapid development and progression of pleural rind and a tendency to spread directly into the chest wall. We divided the pleural into the four regions; upper anterior, upper posterior, lower anterior and lower posterior regions. Pleural changes were more frequently seen in the lower pleural regions than in the upper pleural regions in malignant mesothelioma. (author).

Computed tomography findings of malignant pleural mesothelioma

International Nuclear Information System (INIS)

Shiota, Yutaro; Sato, Toshio; Yamaguchi, Kazuo; Ono, Tetsuya; Kaji, Masaro; Niiya, Harutaka

1994-01-01

Computed tomography (CT) findings were assessed in 7 patients with malignant mesothelioma. CT findings were also reviewed in 9 patients with lung cancer and pleuritis carcinomatosa and in 11 patients with tuberculous pleuritis. Five patients with malignant mesothelioma underwent CT scans twice, on admission and from 1 to 7 months after admission. Tuberculous pleuritis could be distinguished from pleuritis carcinomatosa and malignant mesothelioma by the presence or absence of pleural nodularity and chest wall invasion. Although it was difficult to identify specific CT features clearly distinguishing malignant mesothelioma from pleuritis carcinomatosa, characteristic findings of malignant mesothelioma appeared to include the rapid development and progression of pleural rind and a tendency to spread directly into the chest wall. We divided the pleural into the four regions; upper anterior, upper posterior, lower anterior and lower posterior regions. Pleural changes were more frequently seen in the lower pleural regions than in the upper pleural regions in malignant mesothelioma. (author)

Health Care and Treatment of Posttraumatic Stress Disorder in Asylum Seekers in Germany

OpenAIRE

Gotthardt, Silke

2006-01-01

Asylbewerber stellen in Bezug auf psychische Erkrankungen eine Risikogruppe dar. Viele haben verschiedene Formen organisierter Gewalt erlebt, wie z.B. Verfolgung, Krieg und Folter. Es wurde eine deskriptive Analyse der Angaben von n = 231 Patienten durchgeführt, die in der Forschungs- und Modellambulanz für traumatisierte Flüchtlinge vorstellig wurden. Die Akten wurden mit Hinblick auf folgende Aspekte ausgewertet: psychische Erkrankungen bzw. Diagnosen, Versorgung durch das Gesundheitssyst...

Reconstrucción Tridimensional de Imágenes Ecocardiográficas

Directory of Open Access Journals (Sweden)

Jan Ramírez

2001-04-01

Full Text Available

Las imágenes ecocardiográficas convencionales permiten la evaluación
anatómica y funcional del corazón; por ser bidimensionales son difíciles de interpretar sin un entrenamiento adecuado; los últimos desarrollos han estado orientados a la reconstrucción del corazón en 3 y 4 dimensiones directamente en el equipo de ultrasonido o usando programas especializados. El objetivo es un software en MATLAB™ para la reconstrucción 3D y 4D de imágenes ecocardiográficas.

Aktuelle Tendenzen im computerunterstützten (Fach- Fremdsprachenunterricht

Directory of Open Access Journals (Sweden)

Pawel Szerszeń

2015-03-01

Full Text Available Die heutigen Entwicklungen im Bereich der Kommunikations-und Informationstechnologien tragen u.a. dazu bei,dass wir immer wieder mit neuen E-Learning-Angeboten im (Fach-Fremdsprachenunterricht konfrontiert werden. Diese Tatsa-che stellt u.a. die FremdsprachendidaktikerInnen vor neue Herausforderungen, für die eine kritische Reflexion über die didakti-sche Effizienz von E-Learning-Produkten Vorrang hat. Für eine solche didaktische Reflexion muss jedoch zunächst geklärt wer-den, welche Haupttypen von E-Learning-Produkten bestehen. Das Hauptziel des vorliegenden Beitrags ist somit der Versuch, diezurzeit bestehenden Haupttypen zu erfassen, zu kategorisieren sowie mit einigen Beispielen zu veranschaulichen wie auch aufinteressante Features ausgewählter Lernplattformen/Lernprogramme und auf einige neue E-Learning-Tendenzen hinzuweisen.Dieser Überblick stellt eine nötige und geeignete Grundlage für eine zukünftig mögliche Effizienzreflexion und-diskussion vordem Hintergrund möglicher Produktvergleiche dar

International Conference on Informatics and Management Science (IMS)

CERN Document Server

Informatics and Management Science III

2013-01-01

The International Conference on Informatics and Management Science (IMS) 2012 will be held on November 16-19, 2012, in Chongqing, China, which is organized by Chongqing Normal University, Chongqing University, Shanghai Jiao Tong University, Nanyang Technological University, University of Michigan, Chongqing University of Arts and Sciences, and sponsored by National Natural Science Foundation of China (NSFC). The objective of IMS 2012 is to facilitate an exchange of information on best practices for the latest research advances in a range of areas. Informatics and Management Science contains over 600 contributions to suggest and inspire solutions and methods drawing from multiple disciplines including: ·         Computer Science ·         Communications and Electrical Engineering ·         Management Science ·         Service Science ·         Business Intelligence

Surface characterization of IM7/5260 composites by x-ray photoelectron spectroscopy

International Nuclear Information System (INIS)

Ohno, Satomi; Lee, Moon-Hwan; Lin, Kuen Y.; Ohuchi, Fumio S.

2001-01-01

Surfaces of high-performance carbon fiber/bismeleimide (BMI) composites (IM7/5260) have been characterized by x-ray photoelectron spectroscopy. An experimental technique to separately examine the chemical natures of the carbon fibers and BMI resin in the composite form was developed. This technique uses a flood gun to establish differential charging conditions on the BMI resin. The binding energies from the BMI resin were shifted by an amount of voltage applied to the flood gun, whereas those from the carbon fibers were uniquely determined due to their electrically conducting nature. By adding external bias voltage to the sample, the binding energies for conducting fibers were further shifted from those of the BMI resin, thereby separating the IM7 phase completely from the BMI phase in the binding energy scale, allowing independent measurement of the chemical changes associated with those peaks. Using this technique, the effects of thermal aging and surface plasma treatment on the IM7/5260 composite were studied

Genomic and Expression Profiling of Benign and Malignant Nerve Sheath Profiling of Benign and Malignant Nerve Sheath

Science.gov (United States)

2007-05-01

Benign and Malignant Nerve Sheath Tumors in Neurofibromatosis Patients PRINCIPAL INVESTIGATOR: Matt van de Rijn, M.D., Ph.D. Torsten...Annual 3. DATES COVERED 1 May 2006 –30 Apr 2007 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Genomic and Expression Profiling of Benign and Malignant Nerve...Award Number: DAMD17-03-1-0297 Title: Genomic and Expression Profiling of Benign and Malignant Nerve Sheath Tumors in Neurofibromatosis

Mluvené slovo J. V. Šimáka

Czech Academy of Sciences Publication Activity Database

Kábová, Hana

2011-01-01

Roč. 28, č. 0 (2011), s. 63-74 ISSN 1211-8184 Institutional support: RVO:67985921 Keywords : Šimák, Josef Vítězslav * Czech historiography * popularisation of scientific knowledge Subject RIV: AB - History

Malignant pleural mesothelioma

International Nuclear Information System (INIS)

Wentz, K.U.; Irngartinger, G.; Georgi, P.; Kaick, G. van; Kleckow, M.; Vollhaber, H.H.; Deutsches Krebsforschungszentrum, Heidelberg; Krankenhaus Rohrbach

1986-01-01

In 34 patients with suspected malignant pleural mesothelioma the results of computed tomography are compared with the findings of 67 Ga-scintigraphy. The differential diagnosis of 14 pleural mesotheliomas, 7 pleural carcinoses, 10 inflammatory and 3 other pleural diseases is performed more accurately by CT than by scintigraphy. 67 Ga uptake depends on the thickness of inflammatory as well as malignant lesions. Thus, numerous pleural processes that can be localised by CT escape scintigraphic detection, CT is indicated if there is clinical and radiological suspicion of pleural mesothelioma; in that case, there is hardly any indication for 67 Ga scintigraphy. (orig.)

[Acute surgical treatment of malignant stroke].

Science.gov (United States)

Lilja-Cyron, Alexander; Eskesen, Vagn; Hansen, Klaus; Kondziella, Daniel; Kelsen, Jesper

2016-10-24

Malignant stroke is an intracranial herniation syndrome caused by cerebral oedema after a large hemispheric or cerebellar stroke. Malignant middle cerebral artery infarction is a devastating disease with a mortality around 80% despite intensive medical treatment. Decompressive craniectomy reduces mortality and improves functional outcome - especially in younger patients (age ≤ 60 years). Decompression of the posterior fossa is a life-saving procedure in patients with malignant cerebellar infarctions and often leads to good neurological outcome.

Synchronous atypical fibroxanthoma and Bowen’s disease of the head and neck in an otherwise normal patient – a case report and review of literature [Simultanes Auftreten eines atypischen Fibroxanthoms und Plattenepithelkarzinoms im Kopf-Hals-Bereich – Fallbericht und Literaturübersicht

Directory of Open Access Journals (Sweden)

Eweida, Ahmad

2012-03-01

Full Text Available [english] Although both atypical fibroxanthoma and squamous cell carcinoma arise on top of sun-damaged skin of the elderly, there is no evidence in literature reporting a synchronous presentation of primary lesions of both malignancies in the head and neck regions. We report a case of synchronous atypical fibroxanthoma and squamous cell carcinoma in situ (Bowen’s disease of the head and neck in an otherwise normal old Caucasian male patient. We reviewed the literature for cases of head and neck atypical fibroxanthoma in association with other skin malignancies with an overview over the risk factors and modalities of treatment. We would like to raise the awareness for the concept of multiple synchronous primary malignant lesions and the importance to anticipate and differentiate between different pathologies in order to provide adequate investigations and treatment for the patient. [german] Obwohl sowohl das atypische Fibroxanthom der Haut als auch das Plattenepithelkarzinom bei sonnengeschädigter Haut älterer Menschen gehäuft vorkommen, gibt es in der Literatur keine Beschreibung eines simultanen Auftretens beider Malignome als Primärläsionen im Kopf-Hals-Bereich. Aus diesem Grund möchten wir über einen Fall berichten, bei dem sowohl ein atypisches Fibroxanthom als auch ein Morbus Bowen (als in situ Variante des Plattenepithelkarzinoms im Kopf-Hals-Bereich eines sonst gesunden 74-jährigen männlichen Patienten aufgetreten ist. Auf Grundlage der bestehenden Publikationen von Fällen mit atypischen Fibroxanthomen in Assoziation mit anderen Hautmalignomen, verglichen wir diese mit dem vorliegenden Fall, insbesondere in Hinblick auf die Risikofaktoren und das empfohlene Behandlungsregime. Ein simultanes Auftreten von mehreren primären Hauttumoren verschiedener Entität ist in einigen Fällen möglich und sollte daher insbesondere bei älteren Menschen deutlich häufiger in die Beurteilung und Diagnosestellung mit eingeschlossen werden

MALDI (matrix assisted laser desorption ionization) Imaging Mass Spectrometry (IMS) of skin: Aspects of sample preparation.

Science.gov (United States)

de Macedo, Cristiana Santos; Anderson, David M; Schey, Kevin L

2017-11-01

MALDI (matrix assisted laser desorption ionization) Imaging Mass Spectrometry (IMS) allows molecular analysis of biological materials making possible the identification and localization of molecules in tissues, and has been applied to address many questions on skin pathophysiology, as well as on studies about drug absorption and metabolism. Sample preparation for MALDI IMS is the most important part of the workflow, comprising specimen collection and preservation, tissue embedding, cryosectioning, washing, and matrix application. These steps must be carefully optimized for specific analytes of interest (lipids, proteins, drugs, etc.), representing a challenge for skin analysis. In this review, critical parameters for MALDI IMS sample preparation of skin samples will be described. In addition, specific applications of MALDI IMS of skin samples will be presented including wound healing, neoplasia, and infection. Copyright © 2017 Elsevier B.V. All rights reserved.

Evaluation of the indenter modulus (IM) method in the international round robin test about the cable condition monitoring

International Nuclear Information System (INIS)

Kajimura, Yuusaku

2016-01-01

In order to ensure the reliability and safety of nuclear power plants, the diagnosis of cable aging is important. The Institute of Nuclear Safety System (INSS) has been developing the indenter modulus (IM) method for more than a dozen years. Its usefulness was demonstrated in the research project 'Assessment of cable aging for nuclear power plant' by the Japan Nuclear Energy Safety Organization in 2009. Furthermore, INSS participated in the IAEA Coordinated Research Project in 2013 to 2015, measuring and acquiring data of insulation materials of cables and cable jackets with insulation which had been never measured before by INSS. The main results are as follows. (1) The IM method is useful for new materials (for example, crosslinked polyolefins) which had never been measured before by INSS. (2) The IM method is also applicable to evaluation of cable jackets with insulation made of such materials as chlorosulfonated polyethylene. Therefore, the IM method is evaluated to be useful and applicable for most cable materials except those which have a high IM value initially and which have a small change in IM value during aging. (author)

CopperCore, an Open Source IMS Learning Design Engine

NARCIS (Netherlands)

Vogten, Hubert

2004-01-01

The presentation gives an overview of the approach of the development programme of the OTEC department towards the development of Open Source. The CopperCore IMS Learning Design engine is described as an example of this approach.

Design of data transportation based on dual-port RAM in IMS system

International Nuclear Information System (INIS)

Zhang Guohui; Li Yongping

2010-01-01

Ion mobility spectroscopy (IMS) is a rugged, portable, sensitive, low cost, field instrumental technique capable of trace organic detection and monitoring for environmental pollutants, pesticides, explosives, narcotics, and other analytes, hence it is of great significance to social security and stability. High rate data transmission mechanism between DSP processor and ARM core is required in the electronic system of IMS. After careful comparison of UART and dual port RAM, a new design based on dual port RAM that can be applied to other similar systems. (authors)

I'm Positive: Growing Up with Self-Esteem.

Science.gov (United States)

Kansas State Univ., Manhattan. Cooperative Extension Service.

This document presents "I'm Positive: Growing Up With Self-Esteem," an informal, personal study course designed to strengthen the reader's ability to nurture self-esteem in children from birth through adolescence. Special emphasis is given to four parenting skills: acceptance, encouragement, empowerment, and love. Weekly activities are provided…

vaccination using profilin and NetB proteins in Montanide IMS adjuvant increases protective immunity against experimentally-induced necrotic enteritis

Directory of Open Access Journals (Sweden)

Hyun Soon Lillehoj

2017-10-01

Full Text Available Objective The effects of vaccinating 18-day-old chicken embryos with the combination of recombinant Eimeria profilin plus Clostridium perfringens (C. perfringens NetB proteins mixed in the Montanide IMS adjuvant on the chicken immune response to necrotic enteritis (NE were investigated using an Eimeria maxima (E. maxima/C. perfringens co-infection NE disease model that we previously developed. Methods Eighteen-day-old broiler embryos were injected with 100 μL of phosphate-buffered saline, profilin, profilin plus necrotic enteritis B-like (NetB, profilin plus NetB/Montanide adjuvant (IMS 106, and profilin plus Net-B/Montanide adjuvant (IMS 101. After post-hatch birds were challenged with our NE experimental disease model, body weights, intestinal lesions, serum antibody levels to NetB, and proinflammatory cytokine and chemokine mRNA levels in intestinal intraepithelial lymphocytes were measured. Results Chickens in ovo vaccinated with recombinant profilin plus NetB proteins/IMS106 and recombinant profilin plus NetB proteins/IMS101 showed significantly increased body weight gains and reduced gut damages compared with the profilin-only group, respectively. Greater antibody response to NetB toxin were observed in the profilin plus NetB/IMS 106, and profilin plus NetB/IMS 101 groups compared with the other three vaccine/adjuvant groups. Finally, diminished levels of transcripts encoding for proinflammatory cytokines such as lipopolysaccharide-induced tumor necrosis factor-α factor, tumor necrosis factor superfamily 15, and interleukin-8 were observed in the intestinal lymphocytes of chickens in ovo injected with profilin plus NetB toxin in combination with IMS 106, and profilin plus NetB toxin in combination with IMS 101 compared with profilin protein alone bird. Conclusion These results suggest that the Montanide IMS adjuvants potentiate host immunity to experimentally-induced avian NE when administered in ovo in conjunction with the profilin and

Håndens maligne tumorer

DEFF Research Database (Denmark)

Knudsen, Britt Mejer; Rasmussen, Per Joen Svabo; Lausten, Gunnar Schwarz

2011-01-01

Malignant tumours of the hand are rare and are often misdiagnosed. A painful swelling of the hand or digits are often diagnosed with an infection, benign tumours such as ganglion cysts, or arthritis. Wounds that do not heal despite adequate treatment should be biopsied to rule out malignancy....... A correct diagnosis without delay is important because the life expectancy, due to a metastasis on the hand or fingers is approximately six months....

Ewing's Sarcoma and Second Malignancies

Directory of Open Access Journals (Sweden)

Joshua D. Schiffman

2011-01-01

Full Text Available Ewing's sarcoma (ES is a rare tumor that is most common in children and young adults. Late effects of ES therapy include second cancers, a tragic outcome for survivors of such a young age. This paper will explore the frequencies and types of malignancies that occur after ES. Additionally, it will review how second malignancies have changed with the shift in treatment from high-dose radiation to chemotherapy regimens including alkylators and epipodophyllotoxins. The risk of additional cancers in ES survivors will also be compared to survivors of other childhood cancers. Finally, the possible genetic contribution to ES and second malignancies will be discussed.

Malignant diseases as suicidal motives

Directory of Open Access Journals (Sweden)

Bogdanović Ljiljana

2007-01-01

Full Text Available Introduction Suicide is a conscious and intentional destruction of one’s own life, which occurs as a result of mutual influence of a person’s disposition and motives (facts inspiring the commitment of suicide. It is well known that various diseases, including malignancies, could be important and in some cases the only motive for committing suicide. Objective The purpose of the study was to analyze in detail suicides of persons whose only motive was an established malignant disease. Method The analysis was performed using the autopsy material of the Institute of Forensic Medicine, School of Medicine, University of Belgrade, during the period from 1990 to 2004. The reports on performed medico-legal autopsies were used, as well as history data obtained from the family members of suicidal persons, investigation reports and the available medical documents. Results In 1931 cases there was established suicidal nature of a violent death. Neoplasms were the suicidal motive in 37 persons (1.9%. The basic characteristics of the analyzed sample were predominance of males (26:11, ratio 2.4:1, the age of over 70 years and the highest incidence of malignant lung and breast tumors. Almost all cases were the persons who underwent treatment for malignant neoplasms over a longer period of time. During 19 autopsies (51.3% out of 37, a progressive phase of malignancy was established, i.e. metastases. The data on prior oral announcement of suicide intention were obtained for 70.3% (26 cases, and on previous suicidal attempts only for 13.5% (5 cases. In the majority of cases (78.4% the place of committed suicide was the person’s home. In 16 cases (43.2% the suicide was committed with a firearm. Hanging as a manner of destroying one’s own life was chosen by 12 persons (32.4%, while other ways were less frequently used. Conclusion Although malignancies were not present with high incidence as a suicidal motive in our analyzed sample, such cases require particular

Ein Lehrbuch über Psychiatrie und Psychotherapie – Geschlechtsunterschiede unter der Lupe?

Directory of Open Access Journals (Sweden)

Isabella Heuser

2007-07-01

Full Text Available Anke Rohde und Andreas Marneros haben sich ein hohes Ziel gesetzt: ein übersichtliches Lehrbuch für Psychiatrie und Psychotherapie, das erstmals eine systematische Zusammenstellung des Wissens über geschlechtsspezifische Aspekte von Symptomatologie, Epidemiologie, Diagnostik, Pharmakotherapie und Psychotherapie psychischer Störungen enthält. Bemerkenswert ist dabei zweierlei: Erstens werden bei der Betrachtung geschlechtsspezifischer Unterschiede im Sinne der Genderforschung Frauen und Männer berücksichtigt, zweitens wird ein vollständiger Überblick sowohl über die häufigen und bekannten psychischen Störungen als auch die äußerst seltenen psychiatrischen Erkrankungen der gesamten Altersspanne gegeben. Wenngleich die Qualität der einzelnen Beiträge deutlich zwischen sehr differenzierter und leider auch für ein Handbuch eindeutig zu oberflächlicher Betrachtung variiert, liegt in dem Band ein weitgehend informatives Nachschlagewerk vor, das einen ersten Überblick über die geschlechtsspezifische Psychiatrie gibt.

Method for Estimating Evaporative Potential (IM/CLO) from ASTM Standard Single Wind Velocity Measures

Science.gov (United States)

2016-08-10

IM/CLO) FROM ASTM STANDARD SINGLE WIND VELOCITY MEASURES DISCLAIMER The opinions or assertions contained herein are the private views of the...USARIEM TECHNICAL REPORT T16-14 METHOD FOR ESTIMATING EVAPORATIVE POTENTIAL (IM/CLO) FROM ASTM STANDARD SINGLE WIND VELOCITY... ASTM STANDARD SINGLE WIND VELOCITY MEASURES Adam W. Potter Biophysics and Biomedical Modeling Division U.S. Army Research Institute of Environmental

Die Freunde im und die Freude am Fernsehen

Directory of Open Access Journals (Sweden)

Amina Ovcina Cajacob

2012-09-01

Full Text Available Das Ziel der vorliegenden Arbeit besteht darin, die Wirkungen von Popstars und Popbands auf Jugendliche (13- bis 17-Jährige zu erforschen. Im Mittelpunkt der Interessen steht die Frage, welche Wirkungen aus der Rezeption von Musiksendungen (bzw. Videoclips von Musiksendern entstehen und welche Charakteristika innerhalb der aufgebauten Beziehungen zu den Stars bemerkbar sind. Andererseits wurden die Unterschiede und Parallelen zwischen parasozialen Beziehungen zu den Stars und orthosozialen Beziehungen aufgezeigt. Im Zusammenhang mit der empirischen Untersuchung bezieht sich die Autorin auf den Uses-and-Gratifications-Approach, wobei die bedürfnissbefriedigenden Wirkungen von Musikkanälen und den dazu gehörigen Popstars im Mittelpunkt stehen. Mit Hilfe des Uses-and-Gratifications-Approach wird angenommen, dass das Konsumieren der Musiksendungen und der Musikstars von den Jugendlichen gezielt zur Befriedigung bestimmter Bedürfnisse eingesetzt wird.The objective of this study is to explore the effects of pop stars on adolescents (aged between 13 and 17. The focus of interest is the question what effect music channels (i.e. video clips from music channels produce and what characteristics are noticeable from the formed relationship between adolescents and pop stars. On the other side, parallels and differences have been drawn between the para-social relationships to pop stars and ortho-social relationships. In connection with empirical study, the author also refers to Uses-and Gratification-Approach where the need satisfying effects of music channels and pop stars are in focus. With the help of Uses-and Gratification-Approach it will be assumed, that aim of watching music channels and therefore pop stars will be pointed toward the gratification of specific needs.

Hypersensitivity reactions associated with L-asparaginase administration in 142 dogs and 68 cats with lymphoid malignancies: 2007-2012.

Science.gov (United States)

Blake, Mary Kay; Carr, Brittany J; Mauldin, Glenna E

2016-02-01

Clinically significant hypersensitivity reactions (HSRs) to the chemotherapy drug L-asparaginase are reported in humans and dogs, but frequency in small animals is not well-defined. This study retrospectively evaluated the frequency of HSR to L-asparaginase given by IM injection to dogs and cats with lymphoid malignancies. The medical records of all dogs and cats treated with at least 1 dose of L-asparaginase chemotherapy over a 5-year period were reviewed. A total of 370 doses of L-asparaginase were administered to the dogs, with 88 of 142 dogs receiving multiple doses, and 6 dogs experiencing an HSR. A total of 197 doses were administered to the cats, with 33 of 68 cats receiving multiple doses, and no cats experiencing an HSR. Hypersensitivity reactions were documented in 4.2% of dogs, and in association with 1.6% of L-asparaginase doses administered. These results show that HSRs occur uncommonly among dogs and cats, even with repeated dosing.

Impression cytology diagnosis of ulcerative eyelid malignancy.

Science.gov (United States)

Sen, S; Lyngdoh, A D; Pushker, N; Meel, R; Bajaj, M S; Chawla, B

2015-02-01

The utility of impression cytology in ocular diseases has predominantly been restricted to the diagnosis of dry eye, limbal stem cell deficiency and conjunctival neoplasias. Its role in malignant eyelid lesions remains largely unexplored. Although scrape cytology is more popular for cutaneous lesions, impression cytology, being non-traumatic, has an advantage in small and delicate areas such as the eyelid. The present study has been designed to evaluate its role in the diagnosis and management of malignant eyelid lesions. Thirty-two histopathologically proven malignant eyelid lesions diagnosed over a 2-year period, including 13 basal cell carcinomas, 11 sebaceous carcinomas, four squamous cell carcinomas, two malignant melanomas and two poorly differentiated carcinomas, formed the study group. The results of impression cytology were compared with those of histopathology in the study group and with an age- and sex-matched group of benign cases as controls. The sensitivity of impression cytology was 84% (27/32) for the diagnosis of malignancy and 28% (9/32) for categorization of the type of malignancy. Impression cytology is a simple, useful, non-invasive technique for the detection of malignant ulcerative eyelid lesions. It is especially useful as a follow-up technique for the detection of recurrences. © 2014 John Wiley & Sons Ltd.

Malignant Tumors Of The Heart

International Nuclear Information System (INIS)

Dubrava, J.

2007-01-01

Autoptic prevalence of the heart tumors is 0,01 – 0,3 %. 12 – 25 % of them are malignant tumors and 75 – 88 % are benign. Malignancies are more frequently found in the right heart. Metastatic tumors occur 20 – 40-times more frequently than primary neoplasms. Even 94 % of primary malignant tumors are sarcomas. Most frequent of them are angio sarcomas. Heart metastases are only found in extensive dissemination. Highest prevalence of heart metastases is observed in melanoma, followed by malignant germ cell tumors, leukemia, lymphoma, lung cancer. The clinical presentation is due to the combination of heart failure, embolism, arrhythmias, pericardial effusion or tamponade. The symptoms depend on anatomical localization and the tumor size but not on the histological type. Prognosis of the heart malignancies is poor. Untreated patients die within several weeks to 2 years after the diagnosis was determined. Whenever possible the heart tumor should be resected, despite the surgery is usually neither definite nor sufficiently effective therapy. The patients with completely resectable sarcomas have better prognosis (median of survival 12 – 24 months) than the patients with incomplete resection (3 – 10 months). Complete excision is possible in only less than half of the patients. In some patients chemotherapy, radiotherapy, heart transplantation or combination of them prolonged the survival up to 2 years. Despite of this treatment median of the survival is only 1 year. (author)

Positron emission tomography of malignant tumours at head and neck. Evaluation of the diagnostic value of positron emission tomography by comparison with computed tomography; Positronenemissionstomographie bei malignen Tumoren im Kopf- und Halsbereich. Beurteilung der diagnostischen Wertigkeit der Positronenemissionstomographie im Vergleich zur Computertomographie

Energy Technology Data Exchange (ETDEWEB)

Kettler, Nele

2011-12-02

Imaging methods for early, accurate diagnosis and aftercare of malignant growths is currently one of the most important research topics. The objective of this thesis is to evaluate the diagnostic value of FDG-positron emission tomography by comparison with computed tomography for patients with squamous cell carcinoma, malignant melanoma or sarcoma at head and neck. Measurement criteria are sensitivity and specificity. A retrospective evaluation of 100 examinations on 85 patients of University clinic Aachen was performed. The examination reports were supported by reports from histology, positron emission tomography and computed tomography. In each case, the histological results were assumed to provide a reliable benchmark. Sensitivity and specificity for the primary tumour site, metastatic lymphatic nodes and defined anatomic structures were compared across all patients. Comparisons were also performed on sub groups separated by gender, cancer type and the time and frequency at which tumours arose. The statistic analysis was done with MedCalc. Results: The results for sensitivity and specificity of the primary tumour site were 86.42% and 42.86%, and 64.71% and 66.07%, for positron emission tomography and computed tomography respectively. The results for the lymphatic nodes were 51.52% and 92.86% and 64.71% and 66.07%. When the constituent anatomic structures were evaluated separately, the specificity was significantly higher. The separation by gender showed no difference. Because the classification by tumor type resulted in samples that were of varying size, a comparison was difficult. For the diagnosis of primary tumours, the examination with positron emission tomography was superior, whereas computed tomography proved more effective for the diagnosis of recurrent tumours. For the diagnosis of the main tumour site, both methods were shown to be equally suitable. For the assessment of lymphatic nodes, positron emission tomography was superior to computed tomography

Gerbstoffe aus Potentilla officinalis wirken entzündungshemmend im UV-Erythem-Test und bei Anwendung auf atopischer Haut.

Science.gov (United States)

Hoffmann, Julia; Wölfle, Ute; Schempp, Christoph M; Casetti, Federica

2016-09-01

Das Rhizom von Potentilla officinalis (PO) ist reich an Gerbstoffen und wird traditionell zur äußerlichen Behandlung von Entzündungen der Haut und der Schleimhäute verwendet. Ziel der vorliegenden Arbeit war die Bestätigung der antiinflammatorischen Eigenschaften von PO mittels eines UV-Erythem-Tests und einer klinischen Anwendungsstudie bei atopischer Haut. Die antiinflammatorische Wirkung eines PO-Extrakts (standardisiert auf 2 % Trockensubstanz) wurde in einer prospektiven, randomisierten, placebokontrollierten Doppelblindstudie mit 40 gesunden Erwachsenen im UV-Erythem-Test im Vergleich zu 1 % Hydrocortisonacetat untersucht. Im Rahmen einer prospektiven nicht kontrollierten Studie wurde die Wirkung und Verträglichkeit der 2 % PO-Creme an zwölf Erwachsenen und zwölf Kindern mit atopischer Haut nach Anwendung über zwei Wochen in einem definierten Testareal anhand eines Teil-SCORAD untersucht. Zusätzlich wurde die Beeinflussung der Hautrötung im Testareal photometrisch gemessen. Im UV-Erythem-Test zeigte die PO-Creme eine signifikante Reduktion des Erythemindex im Vergleich zum Vehikel. Die antiinflammatorische Wirkung des Verums entsprach der der 1 % Hydrocortisonacetat-Creme. Die klinische Studie bei Atopikern zeigte eine signifikante Abnahme des Teil-SCORAD und des Erythems im Testareal. Es wurden keine Unverträglichkeitsreaktionen beobachtet. PO als 2%ige Zubereitung besitzt entzündungshemmende Eigenschaften und ist wirksam und gut verträglich auf atopischer Haut. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

MRI of pulmonary perfusion; MRT der Lungenperfusion

Energy Technology Data Exchange (ETDEWEB)

Fink, C. [Klinikum Grosshadern der Ludwig-Maximilians-Universitaet Muenchen (Germany). Institut fuer Klinische Radiologie; Deutsches Krebsforschungszentrum (DKFZ), Abteilung Radiologie, Heidelberg (Germany); Risse, F.; Semmler, W. [Deutsches Krebsforschungszentrum (DKFZ), Abteilung Medizinische Physik in der Radiologie, Heidelberg (Germany); Schoenberg, S.O.; Reiser, M.F. [Klinikum Grosshadern der Ludwig-Maximilians-Universitaet Muenchen (Germany). Institut fuer Klinische Radiologie; Kauczor, H.-U. [Deutsches Krebsforschungszentrum (DKFZ), Abteilung Radiologie, Heidelberg (Germany)

2006-04-15

Lung perfusion is a crucial prerequisite for effective gas exchange. Quantification of pulmonary perfusion is important for diagnostic considerations and treatment planning in various diseases of the lungs. Besides disorders of pulmonary vessels such as acute pulmonary embolism and pulmonary hypertension, these also include diseases of the respiratory tract and lung tissue as well as pulmonary tumors. This contribution presents the possibilities and technical requirements of MRI for diagnostic work-up of pulmonary perfusion. (orig.) [German] Die Perfusion der Lunge ist eine entscheidende Voraussetzung fuer einen effektiven Gasaustausch. Die Bestimmung der Lungenperfusion ist bei verschiedenen Erkrankungen der Lunge fuer Diagnostik und Therapieplanung bedeutsam. Hierzu zaehlen neben Erkrankungen der Lungengefaesse wie akute Lungenembolie und pulmonale Hypertension ebenso Erkrankungen der Atemwege, des Lungengeruests und Lungentumoren. In diesem Beitrag werden die Moeglichkeiten und technischen Voraussetzungen der MRT zur Diagnostik der Lungenperfusion dargestellt. (orig.)

Radiation sensitivity of human malignant lymphocytes

International Nuclear Information System (INIS)

Seshadri, R.; Matthews, C.; Morley, A.A.

1985-01-01

A simple and rapid in vitro technique to assess the sensitivity of human malignant lymphocytes to roentgen irradiation is described. A variety of established malignant lymphocyte cell lines were cloned in microwells and clone survival was used as the end-point. The survival of the clonogenic malignant lymphocyte down to a fraction of approximately 0.001 could be measured accurately. Except for a T-cell line, the radiation sensitivities of the cell lines were similar to that of normal T-lymphocytes. (orig.)

Strukturwandel, Verbandsabstinenz, Tarifflucht : zur Lage der Unternehmen und Arbeitgeberverbände im ostdeutschen verarbeitenden Gewerbe

OpenAIRE

Ettl, Wilfried; Heikenroth, André

1996-01-01

"Im Kontext der am Start der ostdeutschen Transformation vorgenommenen wirtschaftspolitischen Richtungsentscheidungen erwies sich die flächentarifvertragliche Normierung von Arbeits- und Entlohnungsbedingungen für die Arbeitgeberverbände als organisationspolitisch dysfunktional, weil sie der Differenzierung betriebswirtschaftlicher Kostenbedingungen und Interessenlagen im rasanten Strukturwandel nicht gerecht werden konnte. Anhand der Ergebnisse einer Befragung ostdeutscher ...

Capacity Bounds for the Gaussian IM-DD Optical Multiple-Access Channel

KAUST Repository

Chaaban, Anas; Al-Ebraheemy, Omer M. S.; Al-Naffouri, Tareq Y.; Alouini, Mohamed-Slim

2017-01-01

Optical wireless communications (OWC) is a promising technology for closing the mismatch between the growing number of connected devices and the limited wireless network capabilities. Similar to downlink, uplink can also benefit from OWC for establishing connectivity between such devices and an optical access point. In this context, the incoherent intensitymodulation and direct-detection (IM-DD) scheme is desirable in practice. Hence, it is important to understand the fundamental limits of communication rates over an OWC uplink employing IM-DD, i.e., the channel capacity. This uplink, modeled as a Gaussian multiple-access channel (MAC) for indoors OWC, is studied in this paper, under the IM-DD constraints which form the main difference with the standard Gaussian MAC commonly studied in the radio-frequency context. Capacity region outer and inner bounds for this channel are derived. The bounds are fairly close at high signal-to-noise ratio (SNR), where a truncated- Gaussian input distribution achieves the capacity region within a constant gap. Furthermore, the bounds coincide at low SNR showing the optimality of on-off keying combined with successive cancellation decoding in this regime. At moderate SNR, an optimized uniformly-spaced discrete input distribution achieves fairly good performance.

Capacity Bounds for the Gaussian IM-DD Optical Multiple-Access Channel

KAUST Repository

Chaaban, Anas

2017-03-18

Optical wireless communications (OWC) is a promising technology for closing the mismatch between the growing number of connected devices and the limited wireless network capabilities. Similar to downlink, uplink can also benefit from OWC for establishing connectivity between such devices and an optical access point. In this context, the incoherent intensitymodulation and direct-detection (IM-DD) scheme is desirable in practice. Hence, it is important to understand the fundamental limits of communication rates over an OWC uplink employing IM-DD, i.e., the channel capacity. This uplink, modeled as a Gaussian multiple-access channel (MAC) for indoors OWC, is studied in this paper, under the IM-DD constraints which form the main difference with the standard Gaussian MAC commonly studied in the radio-frequency context. Capacity region outer and inner bounds for this channel are derived. The bounds are fairly close at high signal-to-noise ratio (SNR), where a truncated- Gaussian input distribution achieves the capacity region within a constant gap. Furthermore, the bounds coincide at low SNR showing the optimality of on-off keying combined with successive cancellation decoding in this regime. At moderate SNR, an optimized uniformly-spaced discrete input distribution achieves fairly good performance.

CD31-Expression am Primärtumor und Nachweis hämatogen disseminierter Tumorzellen im Knochenmark von Brustkrebspatientinnen

OpenAIRE

Eisenmann, Petra

2005-01-01

Der Nachweis von disseminierten Tumorzellen im Knochenmark von Patientinnen mit primärem Mammakarzinom ist ein wichtiger prognostischer Parameter. In der vorliegenden Arbeit wurde der Nachweis von CD31 am Primärtumor Mammakarzinom mit dem Auftreten von Mikrometastasen im Knochenmark korreliert. Ferner wurde die prognostische Bedeutung von disseminierten Tumorzellen im Knochenmark und die prognostische Bedeutung von CD31 evaluiert. Bei 50 Patientinnen des Gesamtkollektivs von 195 (25,6%) wu...

Ion mobility spectrometry-mass spectrometry (IMS-MS) for on- and offline analysis of atmospheric gas and aerosol species

Science.gov (United States)

Krechmer, Jordan E.; Groessl, Michael; Zhang, Xuan; Junninen, Heikki; Massoli, Paola; Lambe, Andrew T.; Kimmel, Joel R.; Cubison, Michael J.; Graf, Stephan; Lin, Ying-Hsuan; Budisulistiorini, Sri H.; Zhang, Haofei; Surratt, Jason D.; Knochenmuss, Richard; Jayne, John T.; Worsnop, Douglas R.; Jimenez, Jose-Luis; Canagaratna, Manjula R.

2016-07-01

Measurement techniques that provide molecular-level information are needed to elucidate the multiphase processes that produce secondary organic aerosol (SOA) species in the atmosphere. Here we demonstrate the application of ion mobility spectrometry-mass spectrometry (IMS-MS) to the simultaneous characterization of the elemental composition and molecular structures of organic species in the gas and particulate phases. Molecular ions of gas-phase organic species are measured online with IMS-MS after ionization with a custom-built nitrate chemical ionization (CI) source. This CI-IMS-MS technique is used to obtain time-resolved measurements (5 min) of highly oxidized organic molecules during the 2013 Southern Oxidant and Aerosol Study (SOAS) ambient field campaign in the forested SE US. The ambient IMS-MS signals are consistent with laboratory IMS-MS spectra obtained from single-component carboxylic acids and multicomponent mixtures of isoprene and monoterpene oxidation products. Mass-mobility correlations in the 2-D IMS-MS space provide a means of identifying ions with similar molecular structures within complex mass spectra and are used to separate and identify monoterpene oxidation products in the ambient data that are produced from different chemical pathways. Water-soluble organic carbon (WSOC) constituents of fine aerosol particles that are not resolvable with standard analytical separation methods, such as liquid chromatography (LC), are shown to be separable with IMS-MS coupled to an electrospray ionization (ESI) source. The capability to use ion mobility to differentiate between isomers is demonstrated for organosulfates derived from the reactive uptake of isomers of isoprene epoxydiols (IEPOX) onto wet acidic sulfate aerosol. Controlled fragmentation of precursor ions by collisionally induced dissociation (CID) in the transfer region between the IMS and the MS is used to validate MS peak assignments, elucidate structures of oligomers, and confirm the

Pleural spill malign

International Nuclear Information System (INIS)

Camacho Duran, Fidel; Zamarriego, Roman; Gonzalez, Mauricio

2002-01-01

The pleural spills are developed because of an alteration in the mechanisms that usually move between 5 and 10 liters of liquid through the space pleural every 24 hours and this is reabsorbed, only leaving 5 to 20 ml present. The causes more common of spill pleural they are: congestive heart failure, bacterial pneumonia, malign neoplasia and pulmonary clot. The causes more common of pleural spill malign in general are: cancer of the lung, cancer of the breast and lymphomas. In the man, cancer of the lung, lymphomas and gastrointestinal cancer. In the woman, cancer of the breast, gynecological cancer and lung cancer. The paper, includes their characteristics, treatments and medicines

Malignant Transformation of Oral Lichen Planus

Directory of Open Access Journals (Sweden)

Sangeeta Wanjari

2010-01-01

Full Text Available Oral lichen planus (OLP is a chronic inflammatory mucocutaneous disease that frequently involves the oral mucosa. It has been regarded by many authors as a premalignant condition. There has been a continuous debate regarding the possible malignant potential of OLP, and these patients have been recommended to have their lesions monitored two to four times annually. A case of a lichen planus transformed into malignancy is reported here. This case does not provide answers to the ongoing controversy about the innate propensity of OLP to become malignant. However, in view of common occurrence of OLP and unresolved issue regarding its malignant potential (MP, thus case report illustrates the need for histologic confirmation and close follow-up of patients with clinical lesions that have lichenoid features.

Malignant melanoma. Current status; Malignes Melanom. Aktueller Stand

Energy Technology Data Exchange (ETDEWEB)

Winkler, J.K.; Buder-Bakhaya, K.; Enk, A.; Hassel, J.C. [Universitaetshautklinik, Nationales Centrum fuer Tumorerkrankungen, Heidelberg (Germany); Dimitrakopoulou-Strauss, A. [Deutsches Krebsforschungszentrum, Klinische Kooperationseinheit Nuklearmedizin, Heidelberg (Germany)

2017-10-15

The incidence of malignant melanoma is continuously increasing. The prognosis of metastatic disease is still limited. Until a few years ago palliative chemotherapy with a limited response rate was the standard treatment for metastatic melanoma. Immunotherapy and targeted therapy provide new treatment options. Immune checkpoint inhibitors have significantly improved the prognosis. Regional lymph node sonography, computed tomography (CT) of the neck, chest and abdomen and brain magnetic resonance imaging (MRI) are routinely used. As an alternative to CT scans 18 F fluorodeoxyglucose positron emission tomography (FDG-PET) may be used. Immunotherapy provides the chance of long-term disease control in metastatic melanoma. Ipilimumab may provide long-term tumor control in approximately 20% of patients. Median overall survival of approximately 2 years is achieved during therapy with anti-programmed cell death (PD) 1 antibodies. For combined therapy of ipilimumab and nivolumab a response rate of almost 60% is achieved and 2-year survival is also approximately 60%. The range of immune-mediated side effects demands particular consideration. For response evaluation immune-related response criteria were defined. Furthermore, immunotherapeutic approaches, such as talimogene laherparepvec (T-VEC), which is a modified herpes virus can be used for intralesional injection. An individual definition of the appropriate therapy for each patient is of particular importance. In the context of modern therapy regimens close patient monitoring is crucial. (orig.) [German] Die Inzidenz des Melanoms steigt stetig an. Die Prognose bei metastasierter Erkrankung ist weiterhin limitiert. Bis vor wenigen Jahren war eine palliative Chemotherapie mit begrenzten Ansprechraten Standardtherapie des metastasierten Melanoms. Immuntherapie und zielgerichtete Therapien stellen neue Behandlungsoptionen dar. Insbesondere Immuncheckpointinhibitoren haben die Prognose verbessert. Routinemaessig werden die

A Case of Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation: Malignant Triton Tumor

Directory of Open Access Journals (Sweden)

Kenichiro Mae

2013-12-01

Full Text Available Malignant peripheral nerve sheath tumors (MPNST constitute a rare variety of soft tissue sarcomas thought to originate from Schwann cells or pluripotent cells of the neural crest. Malignant triton tumor (MTT, a very rare, highly aggressive soft tissue tumor, is a subgroup of MPNST and is comprised of malignant Schwann cells coexisting with malignant rhabdomyoblasts. We herein report the case of a 24-year-old man who presented a subcutaneous mass in his right thigh. The mass was removed surgically in its entirety and radiation therapy was applied locally to prevent tumor regrowth. Nonetheless, the patient died 10 months after surgery from metastases to the lung and brain. He presented neither cafe-au-lait spots nor cutaneous neurofibromas. The histopathology showed a transition from a neurofibroma to an MTT, making this the second report of an MTT arising from a neurofibroma without neurofibromatosis type 1, an autosomal dominant disorder with which 50-70% of tumors reported in previous studies were associated. A histopathological examination using immunostaining with desmin confirmed this diagnosis. MTT has a poorer prognosis than MPNST and should therefore be regarded as a distinct clinical entity.

Detection capability of the IMS seismic network based on ambient seismic noise measurements

Science.gov (United States)

Gaebler, Peter J.; Ceranna, Lars

2016-04-01

All nuclear explosions - on the Earth's surface, underground, underwater or in the atmosphere - are banned by the Comprehensive Nuclear-Test-Ban Treaty (CTBT). As part of this treaty, a verification regime was put into place to detect, locate and characterize nuclear explosion testings at any time, by anyone and everywhere on the Earth. The International Monitoring System (IMS) plays a key role in the verification regime of the CTBT. Out of the different monitoring techniques used in the IMS, the seismic waveform approach is the most effective technology for monitoring nuclear underground testing and to identify and characterize potential nuclear events. This study introduces a method of seismic threshold monitoring to assess an upper magnitude limit of a potential seismic event in a certain given geographical region. The method is based on ambient seismic background noise measurements at the individual IMS seismic stations as well as on global distance correction terms for body wave magnitudes, which are calculated using the seismic reflectivity method. From our investigations we conclude that a global detection threshold of around mb 4.0 can be achieved using only stations from the primary seismic network, a clear latitudinal dependence for the detection threshold can be observed between northern and southern hemisphere. Including the seismic stations being part of the auxiliary seismic IMS network results in a slight improvement of global detection capability. However, including wave arrivals from distances greater than 120 degrees, mainly PKP-wave arrivals, leads to a significant improvement in average global detection capability. In special this leads to an improvement of the detection threshold on the southern hemisphere. We further investigate the dependence of the detection capability on spatial (latitude and longitude) and temporal (time) parameters, as well as on parameters such as source type and percentage of operational IMS stations.

An Innovative Approach to the Integrated Management System Development: SIMPRO-IMS Web Based Environment

Directory of Open Access Journals (Sweden)

Kristina Zgodavova

2012-12-01

Full Text Available The purpose of this paper is to contribute to learning, knowledge creation and knowledge transfer for building organization innovability by integrating the management systems in the SIMPRO-IMS web based environment. The paper content consists of the interpretation of role-play simulation, role-play simulation process description, methodology, and the employment of role-play simulation outcomes, as well as the discussion of the knowledge thus obtained. Primary the model of the SIMPRO-Q education environment has been developed and tested during a period of 15 years in several industrial organizations as well as service organizations such as Higher Education Institution (HEI and Healthcare Organization (HCO. The newest version SIMPRO-IMS has recently been developed to support a need of integration of management systems and information archiving. With the last development, SIMPRO-IMS web based environment, processes of five ISO systems are integrated for parallel development, implementation, auditing, maintaining and leading. SIMPRO-IMS provides management with the apparatus necessary to realize a systematic and verifiable approach to the creation and control of IMS documentation. At the same time contributes to the preservation of organization memory in response to the growing challenges of globalization and digitalization. The research is limited by the complexity of a real system and possible empiric results verification. The results achieved are verified when people really overcome the resistance to change. This can be assessed thoughtfully only after some period of time. Another limitation is presented by measurability of real enhancement achieved in quality, safety and environmentality of production, and business continuity and social responsibility of an organization. Development and progress in the methodology of SIMPRO-IMS web based environment is encoded in upgrading the SIMPRO database by processes of the environmental management

Doing religion im Phowa-Kurs: Praxeologische und reflexionslogische Studien zum "bewussten Sterben" im Diamantweg-Buddhismus

Directory of Open Access Journals (Sweden)

Werner Vogd

2015-07-01

Full Text Available Im Sinne einer pragmatistischen Perspektive, wie sie zuerst John DEWEY (1987 [1934] in Anschluss an William JAMES formulierte, ist das Religiöse weniger als eine spezifische Art von experience zu verstehen, denn als ein adjustment hin zu einer epistemischen Perspektive, die alle Erfahrungen in einem veränderten Licht erscheinen lässt. Religiosität zielt damit auf ein besonderes Selbst- und Weltverhältnis, in dem die Beziehung zwischen Selbst und Welt aus einer ganzheitlichen Perspektive betrachtet wird. Wie aber können fremde, auf den ersten Blick in ihrer Genese unwahrscheinliche und unter modernen Verhältnissen zudem anzweifelbare religiöse Haltungen und Sinnsysteme etabliert werden? Am Beispiel der im tibetischen Buddhismus verbreiteten Phowa-Meditation des "bewussten Sterbens" wird untersucht, wie für westliche Adept/innen auf den ersten Blick befremdlich und esoterisch anmutende spirituelle Lehren mit zunehmender Praxis an Evidenz und Sinnhaftigkeit gewinnen können, indem sich Gruppenprozesse, Visualisierungen, körperorientierte Übungen und psychisches Erleben zu einem übergreifenden Arrangement verschränken. Die empirische Datengrundlage für die Untersuchung liefern narrative Interviews mit westlich sozialisierten Schüler/innen und Lehrer/innen des Diamantweg-Buddhismus, der derzeit größten buddhistischen Gemeinschaft des tibetischen Buddhismus in Deutschland. Die Auswertung der Interviews erfolgte angelehnt an die dokumentarische Methode, erweitert durch eine Kontexturanalyse, um den Reflexionsverhältnissen gerecht zu werden, die den religiösen Selbst- und Weltbezug aufspannen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1503179

A novel cold-regulated gene from Phlox subulata, PsCor413im1, enhances low temperature tolerance in Arabidopsis.

Science.gov (United States)

Zhou, Aimin; Sun, Hongwei; Feng, Shuang; Zhou, Mi; Gong, Shufang; Wang, Jingang; Zhang, Shuzhen

2018-01-08

Low temperature stress adversely affects plant growth, development, and crop productivity. Analysis of the function of genes in the response of plants to low temperature stress is essential for understanding the mechanism of chilling and freezing tolerance. In this study, PsCor413im1, a novel cold-regulated gene isolated from Phlox subulata, was transferred to Arabidopsis to investigate its function under low temperature stress. Real-time quantitative PCR analysis revealed that PsCor413im1 expression was induced by cold and abscisic acid. Subcellular localization revealed that PsCor413im1-GFP fusion protein was localized to the periphery of the chloroplast, consistent with the localization of chloroplast inner membrane protein AtCor413im1, indicating that PsCor413im1 is a chloroplast membrane protein. Furthermore, the N-terminal of PsCor413im1 was determined to be necessary for its localization. Compared to the wild-type plants, transgenic plants showed higher germination and survival rates under cold and freezing stress. Moreover, the expression of AtCor15 in transgenic plants was higher than that in the wild-type plants under cold stress. Taken together, our results suggest that the overexpression of PsCor413im1 enhances low temperature tolerance in Arabidopsis. Copyright © 2017 Elsevier Inc. All rights reserved.

"ARZT IM GANZEN SPEKTRUM" ["PHYSICIAN IN THE FULL SPEKTRUM"

Directory of Open Access Journals (Sweden)

Mitzkat, Anika

2006-11-01

Full Text Available [english] For more than 20 years teaching in the medical program at Witten/Herdecke Private University has followed the goal of introducing students to the reality of patient care by a practical approach. The “adaptive physician personality” describes the educational objective of a physician who is able to orient towards “the full spectrum” of his professional core competencies. In regard to the “adaptive physician personality” four Integrated Curricula (Communication, Science, Ethics, and Health Economy had been developed along with the introduction of a model medical program in 2000. Witten/Herdecke University thereby today addresses the requirements defined by the New Medical Licensure Act of 27.06.2002 and brings forward at the same time a program which prepares the medical student for the multi-dimensional responsibilities in the reality of modern health care. This article describes the Integrated Curricula exemplified by the Communication curriculum. This relatively young area of medical teaching in Germany is still extensively unexplored concerning evidence-based research about its effectiveness and efficiency of teaching. [german] Die Lehre im Studiengang Humanmedizin an der Privaten Universität Witten/Herdecke (UWH verfolgt seit mehr als 20 Jahren das Ziel, Studierende praxisnah an die Realität der Patientenversorgung heranzuführen. Das Ausbildungsziel des Medizinstudiums ist dabei die ”lernfähige Arztpersönlichkeit”, die sich möglichst „im ganzen Spektrum” ärztlicher Kernkompetenzen zu orientieren vermag. Im Hinblick auf das Ziel der „lernfähigen Arztpersönlichkeit“ wurden mit der Einführung des Modellstudiengangs Medizin im Jahr 2000 vier Integrierte Curricula (Kommunikation, Wissenschaft, Ethik und Gesundheitsökonomie aufgebaut. Die Lehre an der Universität Witten/Herdecke geht damit einerseits auf die Anforderungen, die mit Einführung der neuen Approbationsordnung für Ärzte vom 27.06.2002 an

The risk of malignancy among biologic-naïve pediatric psoriasis patients: A retrospective cohort study in a US claims database.

Science.gov (United States)

Gu, Yun; Nordstrom, Beth L

2017-08-01

Little published literature exists regarding malignancy risk in pediatric psoriasis patients. To compare malignancy risk in biologic-naïve pediatric psoriasis patients with a matched pediatric population without psoriasis. This retrospective cohort study used IMS LifeLink Health Plan Claims data covering 1998-2008. Cancer incidence was compared with the US Surveillance, Epidemiology, and End Results (SEER) data using standardized incidence ratios (SIR), and between cohorts using Cox models. Among 9045 pediatric psoriasis patients and 77,206 comparators, 18 probable or highly probable cancers were identified. Pediatric psoriasis patients had a nonsignificantly lower incidence than comparators (hazard ratio [HR] 0.43, 95% confidence interval [CI] 0.05-3.54). The HR increased to 1.67 (95% CI 0.54-5.18) when cancer diagnosed during the first 90 days of follow-up was included. The pediatric psoriasis cohort had a significantly increased lymphoma rate compared with SEER (SIR 5.42, 95% CI 1.62-12.94), but no significant increase relative to the comparator cohort. Misclassification of disease and outcome might have occurred with patients in the claims database. Patients with pediatric psoriasis showed no significant increase in overall cancer risk compared with those without psoriasis. A potential increased risk for lymphoma was observed when compared with the general population. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Computed tomography in intracranial malignant lymphoma

Energy Technology Data Exchange (ETDEWEB)

Naruse, S; Odake, G; Fujimoto, M; Yamaki, T; Mizukawa, N [Kyoto Prefectural Univ. of Medicine (Japan)

1978-09-01

Malignant lymphoma of the central nervous system has been found more and more often in recent years, partly because of the increased use of radiation and such drugs as steroids and antibiotics. However, the definite diagnosis of this disease is difficult until histological verification has been done by operation or autopsy. Since the revolutionary development of computed tomography, however, several reports have been presented, on the computed tomography of malignant lymphoma of the thorax and abdomen. Nevertheless, only a few cases of intracranial malignant lymphoma have been reported. The purpose of this paper, using four patients, is to emphasize the value of computed tomography in the diagnosis of intracranial malignant lymphoma. The characteristic CT findings of intracranial malignant lymphoma may be summarized follows: (1) the tumors are demonstrated to be well-defined, nodular-shaped, and homogenous isodensity - or slightly high-density - lesions in plain scans, and the tumors homogenously increase in density upon contrast enhancement; (2) the disease always has multifocal intracranial lesions, which are shown simultaneously or one after another, and (3) perifocal edema is prominent around the tumors in the cerebral hemisphere.

Postictal MR-changes. A rare and important differential diagnosis; Postiktale MR-Veraenderungen. Eine seltene und wichtige Differenzialdiagnose

Energy Technology Data Exchange (ETDEWEB)

Hattingen, E.; Raab, P.; Lanfermann, H.; Zanella, F.E.; Weidauer, S. [Johann-Wolfgang-Goethe-Universitaet Frankfurt/Main, Institut fuer Neuroradiologie, Frankfurt (Germany)

2008-11-15

Postictal MR findings are analyzed in the context of MR morphological differential diagnoses. Postictal MRI was performed in 11 patients. The patterns of MR changes and their differential diagnoses were analyzed. Focal accentuation of signal increase in the cortex was found on T2-weighted images in 90% of these cases, pial enhancement in 70% and signal changes of the pulvinar/thalamus in 40%. The most common differential diagnoses were encephalitis, and in tumor patients carcinomatous involvement of the meninges. Postictal MR changes vary widely and are difficult to differentiate from illnesses such as encephalitis and carcinomatosis involving the meninges. Nevertheless, knowledge of the typical pattern of postictal MR findings and the clinical course may help to avoid mistaken diagnoses. (orig.) [German] Postiktale MR-Veraenderungen werden im Kontext ihrer Differenzialdiagnosen analysiert. Elf Patienten wurden postiktal im MRT untersucht. Ausgewertet wurden die MR-tomographischen Befundmuster und ihre Differenzialdiagnosen. Bei 90% der Patienten fanden sich fokale kortikal betonte Signalsteigerungen in der T2-Wichtung, bei 90% Diffusionseinschraenkungen, bei 70% piale Anreicherungen und bei 40% Signalalterationen des Pulvinars/Thalamus. Haeufigste Differenzialdiagnosen waren die Enzephalitis und bei entsprechender Tumoranamnese die Meningeosis carcinomatosa. Postiktale MR-Veraenderungen sind vielgestaltig und nicht immer leicht von Erkrankungen wie insbesondere der Enzephalitis oder der Meningeosis carcinomatosa zu unterscheiden. Dennoch helfen die Kenntnis typischer postiktaler Befallsmuster und der klinische Verlauf, Fehldiagnosen zu vermeiden. (orig.)

MFH Mimic in Breast: A High-Grade Malignant Phyllodes Tumor

Directory of Open Access Journals (Sweden)

A. L. Hemalatha

2012-01-01

Full Text Available Malignant phyllodes tumor is usually diagnosed by the presence of benign duct-like epithelium and malignant mesenchymal tissue. In addition to the usual fibrosarcomatous features, the mesenchymal component may show areas resembling osteogenic sarcoma, chondrosarcoma, liposarcoma, leiomyosarcoma, rhabdomyosarcoma, malignant mesenchymoma, and, very rarely, malignant fibrous histiocytoma. We present one such rare case of malignant phyllodes tumor with malignant fibrous histiocytoma-like stromal differentiation.

Bilişim Teknolojileri Öğretmen Adaylarının E-Kitap ve Etkileşimli E-Kitap Kavramına İlişkin Metaforik Algıları

Directory of Open Access Journals (Sweden)

Seda Özer

2015-04-01

Full Text Available Öz Bu araştırmanın amacı bilişim teknolojileri öğretmen adaylarının e-kitap ve etkileşimli kitaba ilişkin algılarını metafor analizi yoluyla incelemektir. Araştırmanın çalışma grubunu, 2013-2014 öğretim yılı Bahar döneminde Fırat Üniversitesi, Eğitim Fakültesi, Bilgisayar ve Öğretim Teknolojileri Eğitimi lisans programına devam eden (1., 2. ,3. ve 4. sınıf öğretmen adayı oluşturmaktadır. Katılımcılardan “E-kitap …… gibidir. Çünkü…..” ve “Etkileşimli e-kitap …… gibidir. Çünkü…..”  ifadelerini metafor kullanarak doldurmaları istenmiştir. Bilişim teknolojileri öğretmen adaylarından elde edilen bu veriler içerik analizi yöntemi kullanılarak incelenmiştir. Elde edilen veriler doğrultusunda bilişim teknolojileri öğretmen adaylarının e-kitaba yönelik geçerli 153, etkileşimli kitaba yönelik geçerli 151 metafor geliştirdikleri görülmüştür. Araştırmanın bulguları ışığında öğretmen adayları e-kitaba ilişkin olumlu ve olumsuz metaforlar üretirlerken, etkileşimli kitaba yönelik sadece olumlu metaforlar ürettikleri ve etkileşimli e-kitap kullanımını daha cazip gördükleri söylenebilir. Salt metin formatı dışında sunulan etkileşimli kitapların öğrenme sürecinde kullanımının önemi yine bu araştırma sonuçlarıyla desteklenmiştir. Araştırma sonucunda bilişim teknolojileri öğretmen adaylarının e-kitaba ilişkin geliştirdikleri metaforlar arasında ilk sırayı “kolay taşınabilir” metaforu almaktadır. Bu özellik e-kitabın avantajları arasında sayılmaktadır. Öğrencilerin etkileşimli kitaba yönelik geliştirilen metaforları arasında ise ilk sırayı “birden çok duyuya hitap eder” metaforu almıştır. Çoklu ortam materyalleri ile öğrenme ortamının desteklenmesinin öğrenciler için önemi, bu çalışmada vurgulanmıştır. Anahtar Sözcükler: E-kitap, etkileşimli kitap, metafor

Messung der Konzentration von D-Dimeren zur Ermittlung physiologischer Referenzbereiche im Verlauf der Schwangerschaft

OpenAIRE

Pingel, Nadine

2011-01-01

Einleitung: D-Dimere (DDIM) sind Fibrinspaltprodukte. Erhöhte Konzentrationen im Blutplasma sind Ausdruck einer verstärkten Aktivierung des Gerinnungs- und Fibrinolysesystems wie bei venösen Thromboembolien. Ebenfalls einen Zustand erhöhter Hyperkoagulabilität stellt die Schwangerschaft dar. Im Rahmen physiologischer Veränderungen steigen die DDIM in dieser Zeit kontinuierlich an. Referenzbereiche hinsichtlich der DDIM-Konzentration beruhen weitestgehend auf Messungen bei nicht-schwangere...

An approach to malignant mammary phyllodes tumors detection

Directory of Open Access Journals (Sweden)

Ilić Ivan

2009-01-01

Full Text Available Background/Aim. Mammary phyllodes tumors (MPT are uncommon fibroepithelial (biphasic neoplasms whose clinical behavior is difficult to predict on the basis of histological criteria only. They are divided into benign, borderline malignant and malignant groups. Sometimes it appears difficult to distinguish these tumors from other types of soft tissue sarcomas. Because of the relatively scant data on the role of biological markers in MPT histogenesis, we have decided to undertake the following study, trying to shed more light on the issue by investigating the following elements that make up MPT: their histological patterns, biological behavior, enzymohistochemical, histochemical and immunohistochemical characteristics (ICH together with the mast cell analysis. Methods. We examined the biopsy material of 35 MPT in our laboratory. Enzymohistochemistry was performed on frozen sections (method of Crowford, Nachlas and Seligman. The used methods were classical hematoxylin-eosin (H&E; histochemical Massontrichrome, Alcian-blue, Periodic acid Schiff and immunohistochemical LSAB2 method (DacoCytomation. Ki-67, ckit, vimentin, estrogen receptor (ER, progesterone receptor (PR and Her-2 oncoprotein immunohistochemistry was performed on all tumors. Results. The patients were ranged per age from 30-62 years (mean 43.3 years, median 39 years. A total of 35 cases of MPT were included: 20 benign (57%, 6 borderline malignant (17% and 9 malignant (26%. Twenty-two patients (62.8 % underwent segmental mastectomy, while 13 (37.2% had total mastectomies. Twenty-eight patients had negative surgical margins at original resection. The mean size of malignant MPT (7.8 cm was larger than that of benign MPT (4.5 cm. Significant features of the malignant MPT were: stromal cellularity, stromal cellular atypism, high mitotic activity, atypic mitoses, stromal overgrowth, infiltrative tumor contour and heterologous stromal elements. Benign MPT showed strong enzymohistochemical

Hypersensitivity reactions associated with L-asparaginase administration in 142 dogs and 68 cats with lymphoid malignancies: 2007–2012

Science.gov (United States)

Blake, Mary Kay; Carr, Brittany J.; Mauldin, Glenna E.

2016-01-01

Clinically significant hypersensitivity reactions (HSRs) to the chemotherapy drug L-asparaginase are reported in humans and dogs, but frequency in small animals is not well-defined. This study retrospectively evaluated the frequency of HSR to L-asparaginase given by IM injection to dogs and cats with lymphoid malignancies. The medical records of all dogs and cats treated with at least 1 dose of L-asparaginase chemotherapy over a 5-year period were reviewed. A total of 370 doses of L-asparaginase were administered to the dogs, with 88 of 142 dogs receiving multiple doses, and 6 dogs experiencing an HSR. A total of 197 doses were administered to the cats, with 33 of 68 cats receiving multiple doses, and no cats experiencing an HSR. Hypersensitivity reactions were documented in 4.2% of dogs, and in association with 1.6% of L-asparaginase doses administered. These results show that HSRs occur uncommonly among dogs and cats, even with repeated dosing. PMID:26834270

Markers of Oral Lichen Planus Malignant Transformation

Science.gov (United States)

Tampa, Mircea; Mitran, Madalina; Mitran, Cristina; Matei, Clara; Georgescu, Simona-Roxana

2018-01-01

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients' quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression. In this review, we discuss various studies which highlight different molecules as ominous predictors of OLP malignant transformation. PMID:29682099

Editorial: Partizipationschancen im Kulturraum Internet nutzen und gestalten: Das Beispiel Web 2.0

Directory of Open Access Journals (Sweden)

Kerstin Mayrberger

2011-10-01

Full Text Available Hatte man in den Neunzigerjahren das Netz vor allem als virtuelle Realität charakterisiert, das dem realen Alltag gegenübersteht, so wird immer stärker deutlich, wie stark die Kultur der alltäglichen Lebenswelt mit dem Kulturraum Internet verflochten ist. So wird das Netz, wo man online einkauft, Freunde im Chat trifft, sich täglich über aktuelle Nachrichten informiert, immer mehr als Erweiterung des alltäglichen Lebens betrachtet. Dies bedeutet daher auch, dass wer am Netz aktiv partizipiert, zugleich über einen Anteil an gesellschaftlicher Macht verfügt. Politische Kampagnen im Internet oder die Präsentation von Politikern/-innen bei Wahlkämpfen im Netz unterstreichen diesen Trend auf eindrückliche Weise. Damit ist das Internet ist in den letzten Jahren zu einem Kulturraum sui generis avanciert. Zuerst war das Netz vor allem ein vom Sender gesteuertes «Push-Medium», von welchem Informationen rezipiert und heruntergeladen wurden. Nicht jede/r konnte die Funktion des Senders einnehmen. Mit der technischen und sozialen Weiterentwicklung des Internets in den letzten Jahren hin zum so genannten Web 2.0 ist jede/r potenziell ein «Prosumer», also Produzent/in und Konsument/in in einem. Jede/r kann sich dank technisch niedrigschwelliger Softwareangebote potenziell am «Mitmachnetz» beteiligen. Inhalte werden von Einzelnen oder kollaborativ im Netz erstellt und publiziert, (ausgewählt rezipiert und weiterpubliziert. Damit hat sich das neue Netz zu einem «Pull-Medium» weiterentwickelt, das massgeblich von den Beiträgen der Empfänger/innen mitgestaltet wird. Das Internet wird so zu einem wesentlichen Medium der Partizipation. Die These, wonach das Internet immer stärker zu einem partizipativen Medium wird, ist allerdings nicht unumstritten. So wird eingewandt, dass das Pull-Prinzip des Internets sich oft auf private Inhalte bezieht und dass es schwierig ist, in dem unübersichtlichen Netz eine wirksame Gegen

Malignant renal cysts: Diagnostic performance and strong predictors at MDCT

International Nuclear Information System (INIS)

Kim, Dae Yoon; Kim, Jeong Kon; Cho, Kyoung-Sik; Min, Gyeong-Eun; Ahn, Han-Jong

2010-01-01

Background: Utilization of multidetector-row CT (MDCT) is anticipated to improve the diagnostic accuracy and reliability for determining malignant cysts. Purpose: To assess the diagnostic accuracy, interobserver agreement, benefit of consensus reading, and strong predictors of malignancy in determining malignant cystic renal masses at MDCT. Material and Methods: Two radiologists independently rated the probability of malignancy at MDCT in 72 benign and 53 malignant cysts. The accuracy and interobserver agreement for determining malignant cysts were evaluated. The strong predictors of malignancy were determined, and in patients with interobserver disagreement for determining malignant cysts, consensus readings were performed. Results: Az value of the two readers was 0.905-0.936 and the sensitivity and specificity were 85-89% and 83-93%, respectively. The overall interobserver agreement for determining the malignant cyst was good as the κ value was 0.696 (% agreement, 61% (76/125)). Thickened irregular wall, thickened irregular septa, and enhancing soft tissue component were strong predictors for malignancy with both readers. In the 17 patients with interobserver disagreement for determining malignant cysts, the sensitivity was improved from 38-63% to 89% by the consensus reading. Conclusion: At MDCT, some false negative decisions for determining malignant cysts can be corrected by consensus reading, and thickened irregular septa, thickened irregular wall, and enhancing soft tissue component are the strong predictors of malignant cysts

Post-transplant lymphoproliferative disorder in the pelvis successfully treated with consolidative radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Habibeh, Omar; Elsayad, Khaled; Kriz, Jan; Haverkamp, Uwe; Eich, Hans Theodor [University Hospital of Muenster, Department of Radiation Oncology, Muenster (Germany)

2017-01-15

Post-transplant lymphoproliferative disorders (PTLDs) are aggressive malignancies which represent one of the major post-transplant complications. However, treatment options vary significantly and localized disease may be curatively treated with radiotherapy (RT) or surgery. We report a case of recurrent rectal PTLD, which was successfully treated by chemoimmunotherapy followed by RT. We describe a patient who developed a rectal lymphoproliferative lesion 11 years after kidney transplant, which was successfully treated with consolidative RT using 25.4 Gy sequential to chemoimmunotherapy (R-CHOP). RT was well tolerated and the patient showed no signs of grade 3 or 4 toxicity. This patient is free of recurrence 52 months after RT, with an overall survival of 62 months since diagnosis. Conventionally fractionated moderate-dose RT appears to be a tolerable and effective treatment option for localized PTLD if a sufficient systemic treatment cannot be applied. (orig.) [German] Posttransplantationslymphoproliferative Erkrankungen (PTLDs) sind eine haeufige Komplikation nach einer Organtransplantation. Nichtdestotrotz unterscheiden sich die Behandlungsmoeglichkeiten signifikant und vor allem lokalisierte Stadien koennen kurativ entweder mit Strahlentherapie (RT) und/oder Operation behandelt werden. Wir berichten ueber einen Fall einer rezidivierten rektalen PTLD, die erfolgreich mit einer Chemoimmuntherapie mit anschliessender RT behandelt wurde. Wir beschreiben einen Patienten der 11 Jahre nach einer Nierentransplantation eine PTLD entwickelte. Diese wurde erfolgreich mit konsolidierender RT (25,4 Gy) im Anschluss an eine Chemoimmuntherapie (R-CHOP) behandelt. Die RT wurde komplikationslos vertragen und es zeigten sich keine Nebenwirkungen. Das rezidivfreie Ueberleben betrug zum Zeitpunkt der letzten Nachsorgeuntersuchung 52 Monate mit einer Gesamtueberlebenszeit von 62 Monaten seit der Diagnose. Die konventionelle fraktionierte moderat dosierte RT scheint eine gut

Detección de características en imágenes basadas en el tensor de color

OpenAIRE

Caballero, Filadelfio; Sebastian y Zuñiga, Jose Maria

2009-01-01

La correspondencia entre dos imágenes sigue siendo un de los aspectos más críticos de la visión por computador. Su resolución se emplea en numerosas tareas, entre las que destacan: Reconocimiento de objetos o escenas, resolver una estructura 3D entre múltiples imágenes, correspondencia estéreo, y seguimiento de objetos. El descriptor Sift ha demostrado ser el mejor detector de características invariantes en imágenes en escala de gris; sin embargo cuando la imagen tiene una pobre ilu...

ADC mapping of benign and malignant breast tumors

International Nuclear Information System (INIS)

Woodhams, R.; Matsunaga, Keiji; Kan, Shinichi; Hata, Hirofumi; Iwabuchi, Keiichi; Kuranami, Masaru; Watanabe, Masahiko; Hayakawa, Kazushige; Ozaki, Masanori

2005-01-01

The purpose of this study was to investigate the utility of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) value in differentiating benign and malignant breast lesions and evaluating the detection accuracy of the cancer extension. We used DWI to obtain images of 191 benign and malignant lesions (24 benign, 167 malignant) before surgical excision. The ADC values of the benign and malignant lesions were compared, as were the values of noninvasive ductal carcinoma (NIDC) and invasive ductal carcinoma (IDC). We also evaluated the ADC map, which represents the distribution of ADC values, and compared it with the cancer extension. The mean ADC value of each type of lesion was as follows: malignant lesions, 1.22±0.31 x 10 -3 mm 2 /s; benign lesions, 1.67±0.54 x 10 -3 mm 2 /s; normal tissues, 2.09±0.27 x 10 -3 mm 2 /s. The mean ADC value of the malignant lesions was statistically lower than that of the benign lesions and normal breast tissues. The ADC value of IDC was statistically lower than that of NIDC. The sensitivity of the ADC value for malignant lesions with a threshold of less than 1.6 x 10 -3 mm 2 /s was 95% and the specificity was 46%. A full 75% of all malignant cases exhibited a near precise distribution of low ADC values on ADC maps to describe malignant lesions. The main causes of false negative and underestimation of cancer spread were susceptibility artifact because of bleeding and tumor structure. Major histologic types of false-positive lesions were intraductal papilloma and fibrocystic diseases. Fibrocystic diseases also resulted in overestimation of cancer extension. DWI has the potential in clinical appreciation to detect malignant breast tumors and support the evaluation of tumor extension. However, the benign proliferative change remains to be studied as it mimics the malignant phenomenon on the ADC map. (author)

Professionelle Literaturrecherche und -verwaltung im Web [Praxisbericht

OpenAIRE

Schaffert, Sandra

2007-01-01

In diesem Beitrag werden Hinweise für eine professionelle Literaturrecherche und -verwaltung im World Wide Web gegeben. Dazu werden für die pädagogische Ausbildung und Forschung einschlägige Literaturdatenbanken genannt, insbesondere solche, die kostenlos zu nutzen sind. Außerdem werden Tipps für clevere Recherchen sowie eine kurze Übersicht über Web-Werkzeuge zur Verwaltung von bibliografischen Angaben gegeben. (DIPF/Orig.)

Using IMS Learning Design to model collaborative learning activities

NARCIS (Netherlands)

Tattersall, Colin

2006-01-01

IMS Learning Design provides a counter to the trend towards designing for lone-learners reading from screens. It guides staff and educational developers to start not with content, but with learning activities and the achievement of learning objectives. It recognises that learning can happen without

Recognize and classify pneumoconiosis; Pneumokoniosen erkennen und klassifizieren

Energy Technology Data Exchange (ETDEWEB)

Hering, K.G.; Hofmann-Preiss, K. [Klinikum Westfalen, Knappschaftskrankenhaus, Dortmund (Germany)

2014-12-15

In the year 2012, out of the 10 most frequently recognized occupational diseases 6 were forms of pneumoconiosis. With respect to healthcare and economic aspects, silicosis and asbestos-associated diseases are of foremost importance. The latter are to be found everywhere and are not restricted to large industrial areas. Radiology has a central role in the diagnosis and evaluation of occupational lung disorders. In cases of known exposure mainly to asbestos and quartz, the diagnosis of pneumoconiosis, with few exceptions will be established primarily by the radiological findings. As these disorders are asymptomatic for a long time they are quite often detected as incidental findings in examinations for other reasons. Therefore, radiologists have to be familiar with the pattern of findings of the most frequent forms of pneumoconiosis and the differential diagnoses. For reasons of equal treatment of the insured a quality-based, standardized performance, documentation and evaluation of radiological examinations is required in preventive procedures and evaluations. Above all, a standardized low-dose protocol has to be used in computed tomography (CT) examinations, although individualized concerning the dose, in order to keep radiation exposure as low as possible for the patient. The International Labour Office (ILO) classification for the coding of chest X-rays and the international classification of occupational and environmental respiratory diseases (ICOERD) classification used since 2004 for CT examinations meet the requirements of the insured and the occupational insurance associations as a means of reproducible and comparable data for decision-making. (orig.) [German] Im Jahr 2012 waren 6 der 10 am haeufigsten anerkannten Berufskrankheiten Pneumokoniosen. Gesundheitspolitisch und oekonomisch stehen dabei die Silikose und asbestassoziierte Erkrankungen im Vordergrund. Insbesondere Letztere treten ubiquitaer auf und sind nicht an grosse Industriestandorte gebunden

Clustered microcalcifications without mass on mammography : benignancy vs. malignancy

Energy Technology Data Exchange (ETDEWEB)

Han, Yoon Hee; Do, Young Soo; Oh, Hoon Il; Kim, Ki Hwan; Chin, Soo Yil [Korean Cancer Center Hostpital, Seoul (Korea, Republic of); Cho, Byung Jae [Chung Dam Radiologic Clinics, Seoul (Korea, Republic of); Han, Heon [Chungang Gil Hospital, Seoul (Korea, Republic of); Choi, Yeun Hyeun; Han, Boo Kyung [Sam Sung Medical Center, Seoul (Korea, Republic of); Park, Jung Mi [Asan Medical Center, Seoul (Korea, Republic of)

1996-11-01

The purpose of this study is to evaluate the accuracy of differentiation between benign and malignant clustered microcalcifications without mass on mammogram. Fourty six mammograms of 44 patients showing clustered microcalcifications without mass were interpreted blindly by five independent observers majoring in breast imaging from different institutions. Twenty two were malignant (10 infiltrating ductal carcinomas, 12 intraductal carcinomas) and 24 were benign (all fibrocystic disease). The observers judge benignancy or malignancy of microcalcifications. The authors assess the accuracy of differential diagnosis of clustered microcalcifications. Of 24 cases proved benign microcalcifications, five radiologists correctly interpreted 20 on average as benign and of malignant 22 cases, 16 on average were correctly interpreted as malignant. The diagnostic accuracy of malignant microcalcifications was 71.8% on average(63.6%{approx}81.8%) and the diagnostic accuracy for benign microcalcifications was 83% on average(71%{approx}92%). It was 9 among total 46 cases that were misinterpreted by more than three radiologists. Among these 9 cases, malignant microcalcifications that had been misinterpreted as benign were seven, benign microcalcifications misinterpreted as malignant were two. The diagnostic accuracy of clustered malignant microcalcifications(71.8%) without mass on mammogram was lower than that of benign microcalcifications(83.3%). So, in case of suspected malignant microcalcification on mammogram, it is preferable that along with magnification view, histopathologic confirmation by core biopsy must be obtained.

The Relationship between Werner Syndrome and Sinonasal Malignant Melanoma: Two Sibling Cases of Werner Syndrome with Malignant Melanoma

Directory of Open Access Journals (Sweden)

Yoshinori Kadowaki

2017-01-01

Full Text Available Werner syndrome (WS is an autosomal recessive disease characterized by premature aging. Malignant tumors such as thyroid carcinoma and malignant melanoma occur frequently in WS patients. We describe 2 siblings with WS who suffered from sinonasal malignant melanoma (MM. Both patients initially experienced nasal obstruction and recurrent nasal bleeding and died within 2 years of the diagnosis of MM. Otolaryngologists should recognize that WS patients have a high risk for head and neck malignant disease, particularly sinonasal MM, even if they are aged below the expected age range and undergo periodic examinations. Furthermore, it is important that WS patients are aware that a prompt nasal examination is indicated if they experience continuous nasal obstruction or recurrent nasal bleeding.

Power-efficient method for IM-DD optical transmission of multiple OFDM signals.

Science.gov (United States)

Effenberger, Frank; Liu, Xiang

2015-05-18

We propose a power-efficient method for transmitting multiple frequency-division multiplexed (FDM) orthogonal frequency-division multiplexing (OFDM) signals in intensity-modulation direct-detection (IM-DD) optical systems. This method is based on quadratic soft clipping in combination with odd-only channel mapping. We show, both analytically and experimentally, that the proposed approach is capable of improving the power efficiency by about 3 dB as compared to conventional FDM OFDM signals under practical bias conditions, making it a viable solution in applications such as optical fiber-wireless integrated systems where both IM-DD optical transmission and OFDM signaling are important.

Debates y controversias sobre las imágenes de la actualidad internacional. Foto-impacto en las portadas globales

Directory of Open Access Journals (Sweden)

Estrella Israel Garzón

2013-10-01

Full Text Available Las imágenes periodísticas son objeto de debates y controversias. Desde la niña de Trang Bang hasta las imágenes de niñas y mujeres en el terremoto y la epidemia de cólera de Haití en 2010, los comentarios se suceden sobre el valor simbólico y comunicativo de lo representado. Las imágenes de prensa reconocidas como “Foto del año” por la World Press Photo en el periodo comprendido entre los años 2000 y 2011 representan conflictos y catástrofes internacionales en las que los protagonistas son principalmente mujeres, niños y niñas; se trata de imágenes cargadas de drama y pathos. Los ejes de la discusión son la jerarquización en portada frente al derecho a la intimidad, la visibilidad de las personas enfermas y víctimas de catástrofes y la respuesta social ante las imágenes a través de la red.

LC-IMS-MS Feature Finder: detecting multidimensional liquid chromatography, ion mobility and mass spectrometry features in complex datasets.

Science.gov (United States)

Crowell, Kevin L; Slysz, Gordon W; Baker, Erin S; LaMarche, Brian L; Monroe, Matthew E; Ibrahim, Yehia M; Payne, Samuel H; Anderson, Gordon A; Smith, Richard D

2013-11-01

The addition of ion mobility spectrometry to liquid chromatography-mass spectrometry experiments requires new, or updated, software tools to facilitate data processing. We introduce a command line software application LC-IMS-MS Feature Finder that searches for molecular ion signatures in multidimensional liquid chromatography-ion mobility spectrometry-mass spectrometry (LC-IMS-MS) data by clustering deisotoped peaks with similar monoisotopic mass, charge state, LC elution time and ion mobility drift time values. The software application includes an algorithm for detecting and quantifying co-eluting chemical species, including species that exist in multiple conformations that may have been separated in the IMS dimension. LC-IMS-MS Feature Finder is available as a command-line tool for download at http://omics.pnl.gov/software/LC-IMS-MS_Feature_Finder.php. The Microsoft.NET Framework 4.0 is required to run the software. All other dependencies are included with the software package. Usage of this software is limited to non-profit research to use (see README). rds@pnnl.gov. Supplementary data are available at Bioinformatics online.

TELEMED – Teaching Legal Medicine: Neukonzeption der Lehre im Fach Rechtsmedizin an der Universität des Saarlandes

Directory of Open Access Journals (Sweden)

Feiser, Judith

2009-02-01

Full Text Available Das Fach Rechtsmedizin ist Bestandteil der klinischen Lehre des Medizinstudiums. Im Zuge der Neuorientierung der medizinischen Ausbildung durch die Einführung der neuen ärztlichen Approbationsordnung wurde die Lehre am Institut für Rechtsmedizin der Universität des Saarlandes umstrukturiert. Dazu wurde das Lehrkonzept „TELEMED- Teaching Legal Medicine“ entwickelt, bestehend aus eLearning und Kleingruppenunterricht. Im Besonderen wurde bei der Gestaltung des neuen Lehrkonzeptes Wert darauf gelegt, die Lehre praxisbezogen zu gestalten. Aus diesem Anlass wurde am Ende des Wintersemesters (WS 2007/08 eine Evaluation mittels Fragebogen durchgeführt. An der Evaluation nahmen insgesamt 84 Studierende teil. Da das neue Lehrkonzept erstmals im WS 2007/08 Anwendung fand, konnte nicht mit früheren Semestern verglichen werden. Jedoch zeigten die Ergebnisse der Evaluation im Gesamten eine hohe Akzeptanz und positive Einschätzung des Konzeptes bei den Studierenden. Ferner ließ sich feststellen, dass die Verwendung von eLearning im Fach Rechtsmedizin einen großen Beitrag zur Umsetzung der praxisorientierten Lehre liefert.

Primary Malignant Bone Tumours at the University Teaching ...

African Journals Online (AJOL)

Introduction: Primary malignant bone tumours include malignancies arising primarily from bone tissue. This is opposed to secondary bone tumours in which case the neoplastic elements arise primarily from other sites within the body and secondarily spread to bone. Primary malignant bone tumours are generally ...

Malignant insulinoma: The problems of tumour localization and ...

African Journals Online (AJOL)

Malignant insulinomas of the pancreas are rare tumours, accounting for 10% of ... Histological examination showed a R-cell malignant tumour of the pancreas with ... Associated vaso-. SA MEDICAL JOURNAL VOLUME 63 23 APRIL 1983 ... 52 cases of pancreatic endocrine malignant tumours, which have similar behaviour.

Prevalence of mabDAS-1 positivity in biopsy specimens from the esophagogastric junction

NARCIS (Netherlands)

Rogge-Wolf, Claudia; Seldenrijk, Cornelis A.; Das, Kiron M.; Timmer, Robin; Breumelhof, Ronald; Smout, André J. P. M.; Amenta, Peter S.; Griffel, Louis H.

2002-01-01

OBJECTIVE: Intestinal metaplasia (IM) is a precursor for malignancies at the esophagogastric junction. A monoclonal antibody, mAbDAS-1, can probably identify cellular characteristics of IM before the appearance of goblet cells. The aim of this study was to examine the prevalence of mAbDAS-1

QUARTERLY TECHNICAL REPORT FOR IN-MINE (IM) SYSTEM

International Nuclear Information System (INIS)

Zvi H. Meiksin

2001-01-01

A circuit that had been earlier lab-tested to eliminate multi-antenna interference in the In-mine (IM) system was fabricated, implemented and tested successfully in a system setting. An adaptive, tracking comb-filter for the through-the-earth (TTE) communications system was designed and implemented. This resulted in noticeable noise reduction. Studies for multi-channel transmission have begun

Differential diagnoses of spinal tumors; Differenzialdiagnose spinaler Tumoren

Energy Technology Data Exchange (ETDEWEB)

Yilmaz, U. [Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg/Saar (Germany)

2011-12-15

A wide variety of degenerative, inflammatory and vascular diseases can resemble the clinical presentation and imaging findings of spinal tumors. This article provides an overview of the most frequent diseases which are important to recognize for diagnostic imaging of the spine. (orig.) [German] Eine Vielzahl degenerativer, entzuendlicher und vaskulaerer Erkrankungen kann das klinische Bild und radiologische Befunde spinaler Tumoren imitieren. Dieser Artikel dient der Uebersicht ueber die haeufigsten dieser Erkrankungen, deren Kenntnis wichtig fuer die spinale Bildgebung ist. (orig.)

Ewing's Sarcoma as a Second Malignancy in Long-Term Survivors of Childhood Hematologic Malignancies.

Science.gov (United States)

Wolpert, Fabian; Grotzer, Michael A; Niggli, Felix; Zimmermann, Dieter; Rushing, Elisabeth; Bode-Lesniewska, Beata

2016-01-01

Modern multimodal treatment has significantly increased survival for patients affected by hematologic malignancies, especially in childhood. Following remission, however, the risk of developing a further malignancy is an important issue. The long-term estimated risk of developing a sarcoma as a secondary malignancy is increased severalfold in comparison to the general population. Ewing's sarcoma family encompasses a group of highly aggressive, undifferentiated, intra- and extraosseous, mesenchymal tumors, caused by several types of translocations usually involving the EWSR1 gene. Translocation associated sarcomas, such as Ewing sarcoma, are only rarely encountered as therapy associated secondary tumors. We describe the clinical course and management of three patients from a single institution with Ewing's sarcoma that followed successfully treated lymphoblastic T-cell leukemia or non-Hodgkin lymphoma. The literature on secondary Ewing's sarcoma is summarized and possible pathogenic mechanisms are critically discussed.

NDIA 2018 IM and EM Technology Symposium: Innovative Insensitive Munition Solutions for Enhanced Warfighter Effectiveness

Science.gov (United States)

2018-04-26

2018 IM & EM TECHNOLOGY SYMPOSIUM INNOVATIVE INSENSITIVE MUNITION SOLUTIONS FOR ENHANCED WARFIGHTER EFFECTIVENESS April 23 – 26, 2018 Doubletree by...IM & EM TECHNOLOGY SYMPOSIUM On behalf of the Insensitive Munitions and Energetic Materials Committee and our MSIAC partner, I would like to...welcome you to the 2018 Insensitive Munitions and Energetic Materials Technology Symposium. This international gathering of the top chemists, system

SPECT in psychiatry; Die Bedeutung der Hirn-SPECT in der Psychiatrie

Energy Technology Data Exchange (ETDEWEB)

Kasper, S [Universitaetsklinik fuer Psychiatrie, Wien (Austria); Gruenwald, F [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin; Danos, P [Psychiatrische Universitaetsklinik, Bonn (Germany); Walter, H [Universitaetsklinik fuer Psychiatrie, Wien (Austria); Klemm, E [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin; Bruecke, T [Universitaetsklinik fuer Neurologie, Wien (Austria); Podreka, I [Universitaetsklinik fuer Neurologie, Wien (Austria); Biersack, H J [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin

1994-10-01

In the last fifteen years different attempts have been undertaken to understand the biological basis of major psychiatric disorders. One important tool to determine patterns of brain dysfunction is single emission computed tomography (SPECT). Whereas SPECT investigations are already a valuable diagnostic instrument for the diagnosis of dementia of the Alzheimer Type (DAT) there have not been consistent findings that can be referred to as specific for any other particular psychiatric diagnostic entity. Nevertheless, SPECT studies have been able to demonstrate evidence of brain dysfunction in patients with schizophrenia, depression, anxiety disorders, and substance abuse in which other methods showed no clear abnormality of brain function. Our manuscript reviews the data which are currently available in the literature and stresses the need for further studies, especially for prediction and monitoring psychiatric treatment modalities. (orig.) [Deutsch] In den vergangenen 15 Jahren wurde durch verschiedene methodologische Ansaetze versucht, die biologischen Ursachen psychiatrischer Erkrankungen naeher zu erforschen. Als eine bedeutende Methode hat sich dabei die Single-Photonen-Emissions-Computertomographie (SPECT) herausgestellt. Waehrend die SPECT-Untersuchungen bereits Eingang in die Routinediagnostik bei Demenzen vom Alzheimer-Typ gefunden haben, konnten fuer weitere psychiatrische Erkrankungen noch keine eindeutigen Befunde etabliert werden. Mit der SPECT-Methode ist es jedoch gelungen, funktionelle Veraenderungen des Gehirns von psychiatrischen Erkrankungen darzustellen, wie z.B. Schizophrenie, Depression, Angsterkrankungen bzw. Substanzmissbrauch. In Forschungsprotokollen wird durch die SPECT-Methode versucht, abzuklaeren, inwieweit es moeglich ist, innerhalb der Erkrankungsentitaeten psychiatrischer Erkrankungen oder auch diese uebergreifend eine Subklassifizierung zu finden und evtl. Gehirnsysteme ausfindig zu machen, die mit einer spezifischen

Magnetic resonance imaging in clinical diagnosis of dementia; Die Magnetresonanztomographie in der klinischen Demenzdiagnostik

Energy Technology Data Exchange (ETDEWEB)

Schroeder, J. [Sektion Gerontopsychiatrie, Psychiatrische Universitaetsklinik Heidelberg (Germany); Sektion Gerontopsychiatrie, Psychiatrische Universitaetsklinik, Vossstr. 4, 69115, Heidelberg (Germany); Pantel, J.; Schoenknecht, P. [Sektion Gerontopsychiatrie, Psychiatrische Universitaetsklinik Heidelberg (Germany); Essig, M. [Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum Heidelberg (Germany)

2003-07-01

Dementing disorders belong to the most frequent neuropsychiatric diseases of the elderly population with prevalence rates of 5% in the 75 year old, but more than 10% in subjects older than 80 years. It is broadly accepted that the dementias are not caused by a single etiological factor but are attributed to a variety of different disease processes that affect the brain either directly or indirectly. According to pathoanatomic studies, two thirds of all dementias are caused by Alzheimer's disease (AD). Early recognition and differential diagnosis, which represent an important prerequisite for an optimized therapy, can be facilitated considerably by neuroimaging as well as by molecular biological findings. Therapeutic approaches include general medical management, psychosocial interventions as well as pharmacotherapy of cognitive and non-cognitive deficits. In general, early intervention using a combination of different therapeutic measures is recommended. In future, structural and functional neuroimaging might not only be used for diagnostic purposes but also to objectify and monitor the effect of treatment on relevant brain structures (orig.) [German] Mit einer Praevalenz von ca. 5% bei den ueber 75-Jaehrigen, aber ueber 10% bei den ueber 80-Jaehrigen gehoeren dementielle Erkrankungen zu den haeufigsten geriatrischen Leiden. Dementielle Erkrankungen haben keine einheitliche Ursache, sondern koennen durch eine Vielzahl das Gehirn unmittelbar bzw. mittelbar betreffende Krankheitsprozesse verursacht werden. Nach pathoanatomischen Studien sind ca. 2/3 der Demenzen auf die Alzheimer-Demenz (AD) zu beziehen. Frueherkennung und Differenzialdiagnostik - die Voraussetzungen einer optimierten Behandlung - koennen durch bildgebende Verfahren und molekularbiologische Befunde erheblich vereinfacht werden. Zur Therapie sind allgemeinmedizinische Massnahmen, psychosoziale Interventionen sowie die Pharmakotherapie kognitiver Defizite und nichtkognitiver Symptome bekannt

Harnessing water power in the larger Hannover area. Study commissioned by the local administration union larger Hannover area; Nutzung der Wasserkraft im Grossraum Hannover. Eine Studie im Auftrag des Zweckverbandes Grossraum Hannover

Energy Technology Data Exchange (ETDEWEB)

Sahling, U [comp.

1993-12-31

Within the framework of an inventory of possible sites for hydroelectric power plants in the larger Hannover area, 60 sites in the rural district of Hannover were more closely investigated. 57 of these were former water mills and 3 were hydraulic structures that have nothing to do with former water mills. 29 water mills are to be considered as dismantled in hydraulic engineering terms, 8 are in operation, and 20 are decommissioned. Furthermore, 2 weirs and 1 barrage were included in the investigation.- In the area of the city of Hannover, there are four more sites of hydroelectric power plants, of which one is dismantled, two are decommissioned and one is in operation.- In order to complement the inventory, object expertises of different depths were prepared for eight selected sites. They permit a qualified assessment of the chances of reactivation of each site, taking the respective specific conditions into account. At the same time, they represent a first step towards detailed advice for a prospective operator (orig.). [Deutsch] Im Rahmen der Studie zur Bestandserhebung von moeglichen Standorten fuer Wasserkraftanlagen im Grossraum Hannover wurden 60 Standorte im Landkreis Hannover naeher untersucht. Es handelt sich um 57 ehemalige Wassermuehlen und 3 wasserbauliche Anlagen, die nichts mit ehemaligen Wassermuehlen zu tun haben. 29 Wassermuehlen sind im wasserbaulichen Sinn als beseitigt anzusehen, 8 sind in Betrieb, 20 liegen still. Darueberhinaus wurden 2 Wehre und 1 Stauanlage in die Untersuchungen einbezogen. Im Gebiet der Stadt Hannover befinden sich 4 weitere Wassrkraftstandorte, von denen einer als beseitigt anzusehen ist, zwei stilliegen und einer in Betrieb ist. Ergaenzend zu der Bestandserhebung wurden fuer acht ausgewaehlte Standorte Objektgutachten unterschiedlicher Bearbeitungstiefe erstellt. Sie ermoeglichen eine qualifizierte Beurteilung der Reaktivierungschancen unter Beruecksichtigung der jeweiligen standortspezifischen Besonderheiten

Spannungsaktivierte Natriumkanäle im Corpus luteum des Primaten und ihre Rolle bei der Regulation von Steroidproduktion und Luteolyse

OpenAIRE

Bulling, Andreas

2008-01-01

Im Ovar des Menschen und im Corpus Luteum des Rhesusaffen konnte die mRNA für einen bislang nur im peripheren Nervensystem und in neuroendokrinen Zellen gefundenen spannungsaktivierten Natriumkanal (eNaK, SCN9A) nachgewiesen werden. In kultivierten humanen Granulosaluteinzellen wurden sowohl die Transkriptmenge, als auch die durch depolarisierende Spannungspulse ausgelösten, TTX-sensitiven transienten Ströme durch hCG negativ reguliert. Trotz des gleichzeitigen Vorkommens spannungsaktivierter...

De novo malignancy after pancreas transplantation in Japan.

Science.gov (United States)

Tomimaru, Y; Ito, T; Marubashi, S; Kawamoto, K; Tomokuni, A; Asaoka, T; Wada, H; Eguchi, H; Mori, M; Doki, Y; Nagano, H

2015-04-01

Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. We clarified the incidence of de novo malignancy after pancreas transplantation in Japan. Copyright © 2015 Elsevier Inc. All rights reserved.

Progress in surgical palliative treatment for malignant obstructive jaundice

Directory of Open Access Journals (Sweden)

LIANG Zhang

2013-06-01

Full Text Available Obstructive jaundice, also known as surgical jaundice, is divided into benign and malignant types. Most of the patients newly diagnosed with malignant obstructive jaundice have lost the opportunity of receiving radical surgery due to its insidious onset, so surgical palliative treatment is very important for patients with advanced malignant obstructive jaundice. This paper elaborates on various current modalities of surgical palliative treatment for malignant obstructive jaundice. Appropriate modality of surgical palliative treatment is of great significance for patients with advanced malignant obstructive jaundice.

Low-SNR Capacity of Parallel IM-DD Optical Wireless Channels

KAUST Repository

Chaaban, Anas; Rezki, Zouheir; Alouini, Mohamed-Slim

2016-01-01

The capacity of parallel intensity-modulation and direct-detection (IM-DD) optical wireless channels with total average intensity and per-channel peak intensity constraints is studied. The optimal intensity allocation at low signal-to-noise ratio

End-to-End Availability Analysis of IMS-Based Networks

DEFF Research Database (Denmark)

Kamyod, Chayapol; Nielsen, Rasmus Hjorth; Prasad, Neeli R.

2013-01-01

Generation Networks (NGNs). In this paper, an end-to-end availability model is proposed and evaluated using a combination of Reliability Block Diagrams (RBD) and a proposed five-state Markov model. The overall availability for intra- and inter domain communication in IMS is analyzed, and the state...

Mapping IMS Learning Design and Moodle. A first understanding

NARCIS (Netherlands)

Burgos, Daniel; Tattersall, Colin; Dougiamas, Martin; Vogten, Hubert; Koper, Rob

2006-01-01

Please, cite this publication as follows: Burgos, D., Tattersall, C., Dougiamas, M., Vogten, H., & Koper, E. J. R. (2006). Mapping IMS Learning Design and Moodle. A first understanding. Proceedings of Simposo Internacional de Informática Educativa (SIIE06), León, Spain: IEEE Technical Committee on

Distance tracking scheme for seamless handover in IMS-based ...

African Journals Online (AJOL)

This paper proposes a fast and seamless handover scheme for systems based on IP Multimedia Subsystem (IMS) architectural framework with Universal Mobile Telecommunications System (UMTS) access network. In the scheme the location, direction and movement pattern of a Mobile Node (MN) in a network cell are ...

The presence of dysplastic nevus remnants in malignant melanomas. A population-based study of 551 malignant melanomas.

Science.gov (United States)

Hastrup, N; Osterlind, A; Drzewiecki, K T; Hou-Jensen, K

1991-08-01

We examined 512 malignant melanomas, representing all newly diagnosed cutaneous malignant melanomas, excluding lentigo maligna melanomas, from the period October 1, 1982 to March 31, 1985 occurring in the region of eastern Denmark in patients aged 20-79 years for the presence of dysplastic nevus remnants. Criteria for the diagnosis of a dysplastic nevus remnant include all the following changes (a) lentiginous or epithelioid melanocyte hyperplasia, (b) cytologic melanocyte atypia, (c) eosinophilic fibroplasia, (d) lamellar fibroplasia, and (e) lymphocytic infiltration in the dermis. Dysplastic nevus remnants were found in association with 34 (7%) of the evaluable 512 malignant melanomas. Fourteen (41%) of the remnants were of compound nevus type. In nine (27%) of the remnants, atypia was pronounced. Most (62%) dysplastic nevus remnants were contiguous to thin superficial spreading melanomas. We conclude from this population-based study that about 7% of malignant melanomas arise in prior dysplastic nevi.

Reduced-intensity conditioning for the treatment of malignant and life-threatening non-malignant disorders.

Science.gov (United States)

Slavin, Shimon; Aker, Mehmet; Shapira, Michael Y; Resnick, Igor; Bitan, Menachem; Or, Reuven

2003-01-01

Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeutic tool for the treatment of an otherwise incurable broad spectrum of malignant and non-malignant diseases. Until recently, BMT was used primarily to replace a malignant, genetically abnormal or deficient immunohematopoietic compartment and therefore, highly toxic myeloablative regimens were considered mandatory for more effective eradication of all undesirable host-derived hematopoietic cells, including stem cells and their progeny. Our preclinical and ongoing clinical studies indicated that much more effective eradication of host immunohematopoietic system cells can be mediated by donor lymphocytes in the process of adoptive allogeneic cell therapy following BMT. Thus, eradication of all malignant cells, especially in patients with CML and, to a lesser extent, in patients with other hematologic malignancies can be accomplished despite complete resistance of puch tumor cells to maximally tolerated doses of chemoradiotherapy. Our cumulative experience suggested that graft-versus-malignancy effects might be used as a tool for eradication of otherwise resistant tumor cells of host origin. We speculated that the therapeutic benefit of BMT may be improved by using safer conditioning for engraftment of donor stem cells induce host-versus-graft unresponsiveness to enable engraftment of donor lymphocytes for subsequent induction of graft-versus-malignancy effects, or even graft-versus-autoimmunity and graft-versus-genetically abnormal cells. In other words, focusing on more selective and smarter rather than stronger modalities. Effective BMT procedures may be accomplished without lethal conditioning of the host, using a new, well-tolerated and user-friendly non-myeloablative regimen, thus eliminating or minimizing immediate and late procedure-related toxicity and mortality. It appears that initial induction of graft tolerance, mediated by engraftment of donor stem cells, leads

International Conference on Informatics and Management Science (IMS) 2012

CERN Document Server

Informatics and Management Science VI

2013-01-01

The International Conference on Informatics and Management Science (IMS) 2012 will be held on November 16-19, 2012, in Chongqing, China, which is organized by Chongqing Normal University, Chongqing University, Shanghai Jiao Tong University, Nanyang Technological University, University of Michigan, Chongqing University of Arts and Sciences, and sponsored by National Natural Science Foundation of China (NSFC). The objective of IMS 2012 is to facilitate an exchange of information on best practices for the latest research advances in a range of areas. Informatics and Management Science contains over 600 contributions to suggest and inspire solutions and methods drawing from multiple disciplines including: ·         Computer Science ·         Communications and Electrical Engineering ·         Management Science ·         Service Science ·         Business Intelligence

Statistical observations on postirradiation skin malignancies reported in Japan

Energy Technology Data Exchange (ETDEWEB)

Okazaki, Michiharu; Ogata, Katsumi; Inoue, Shouhei (Miyazaki Medical Coll., Kiyotake (Japan))

1989-01-01

A review was made on 412 cases of postirradiation skin malignancies reported in Japan up to March 1988. The ratio of male to female was 2:1. Histologically, squamous cell carcinoma occupied 60% of all cases. The incidence of sarcoma has recently been increased. Sixty percent of all skin malignancies resulted from irradiation for benign diseases. Radiotherapy has recently become the treatment of choice for malignancy. The incidence of malignancy resulting from occupational exposure has remained unchanged. The latency period before the development of radiation-induced malignancy varied in the following order with cause or primary disease: occupation>benign tumors>malignant tumors; and it varied with histology in the following order: basal cell epithelioma>squamous cell carcinoma>sarcoma. Malignant tumors treated with large doses of high energy photon beams were likely to develop sarcomas in a relatively short latency period of time. (N.K.).

75 FR 64694 - Approval for Expanded Manufacturing Authority; Foreign-Trade Subzone 33E; DNP IMS America...

Science.gov (United States)

2010-10-20

... Manufacturing Authority; Foreign-Trade Subzone 33E; DNP IMS America Corporation (Thermal Transfer Ribbon Printer..., grantee of FTZ 33, has requested an expansion of the scope of manufacturing authority on behalf of DNP IMS...-6636, 2/10/2010) and the application has been processed pursuant to the FTZ Act and the Board's...

A Unidimensional Instrument for Measuring Internal Marketing Concept in the Higher Education Sector: IM-11 Scale

Science.gov (United States)

Yildiz, Suleyman Murat; Kara, Ali

2017-01-01

Purpose: Although the existing internal marketing (IM) scales include various scale items to measure employee motivation, they fall short of incorporating the needs and expectations of service sector employees. Hence, the purpose of this study is to present a practical instrument designed to measure the IM construct in the higher education sector.…

The implementation of the Plan Esperanza and response to the imPACT Review.

Science.gov (United States)

Vidaurre, Tatiana; Santos, Carlos; Gómez, Henry; Sarria, Gustavo; Amorin, Edgar; López, Marga; Regalado, Roxana; Manrique, Javier; Tarco, Duniska; Ayestas, Carlos; Calderón, Mónica; Mas, Luis; Neciosup, Silvia; Salazar, Miriam; Chávez, Juan Carlos; Ubillus, Milward; Limache, Abel; Ubillus, José Carlos; Navarro, Jeannie; Sarwal, Kavita; Sutcliffe, Simon; Gutiérrez-Aguado, Alfonso; Silva, Marianela; Mena, Amalia; Guillén, María Eugenia; Castañeda, Carlos; Abugattas, Julio

2017-10-01

Following the implementation of the National Cancer Prevention and Control Results-based Budget Programme (PpR Cancer-024) in 2011, the Peruvian Government approved the Plan Esperanza-a population-based national cancer control plan-in 2012. Legislation that ensured full government-supported funding for people who were otherwise unable to access or afford care and treatment accompanied the Plan. In 2013, the Ministry of Health requested an integrated mission of the Programme of Action for Cancer Therapy (imPACT) report to strengthen cancer control in Peru. The imPACT Review, which was executed in 2014, assessed Peru's achievements in cancer control, and areas for improvement, including cancer control planning, further development of population-based cancer registration, increased prevention, early diagnosis, treatment and palliative care, and the engagement and participation of civil society in the health-care system. This Series paper gives a brief history of the development of the Plan Esperanza, describes the innovative funding model that supports it, and summarises how funds are disseminated on the basis of disease, geography, and demographics. An overview of the imPACT Review, and the government's response in the context of the Plan Esperanza, is provided. The development and execution of the Plan Esperanza and the execution of and response to the imPACT Review demonstrates the Peruvian Government's commitment to fighting cancer across the country, including in remote and urban areas. Copyright © 2017 Elsevier Ltd. All rights reserved.

Unexpected second primary malignancies detected by f-18 FDG PET/CT during follow-up for primary malignancy: Two case report

Energy Technology Data Exchange (ETDEWEB)

Bang, Ji In; Lee, Eun Seong; Kim, Tae Sung; Kim, Seok Ki [Nuclear Medicine, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)

2015-03-15

As the survival rate of cancer patients has increased over the last few decades, the risk of cancer survivors developing second primary malignancies has gained attention. We report two rare cases of second primary hematologic malignancy detected by 18F-fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) during follow-up for primary solid malignancies. Acute lymphoblastic leukemia developed in a breast cancer patient and non-Hodgkin lymphoma in an anal cancer patient. F-18 FDG PET/CT findings led to the diagnosis of unexpected second primary hematologic malignancy in cancer survivors in these two cases.

Unexpected second primary malignancies detected by f-18 FDG PET/CT during follow-up for primary malignancy: Two case report

International Nuclear Information System (INIS)

Bang, Ji In; Lee, Eun Seong; Kim, Tae Sung; Kim, Seok Ki

2015-01-01

As the survival rate of cancer patients has increased over the last few decades, the risk of cancer survivors developing second primary malignancies has gained attention. We report two rare cases of second primary hematologic malignancy detected by 18F-fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) during follow-up for primary solid malignancies. Acute lymphoblastic leukemia developed in a breast cancer patient and non-Hodgkin lymphoma in an anal cancer patient. F-18 FDG PET/CT findings led to the diagnosis of unexpected second primary hematologic malignancy in cancer survivors in these two cases

Genital tract malign ancies in postmenopausal women

International Nuclear Information System (INIS)

Khursheed, F.; Jatoi, N.; Das, C.M.

2010-01-01

Background: The most common malignancy in women is breast carcinoma. The next common cancer is genital tract malignancies which constitute 14% of cancers in women. Objective of this study was to determine the type and frequency of genital tract malignancy in postmenopausal women and to find the age distribution of genital tract malignancies. Methods: This descriptive cross sectional study was conducted in Department of Obstetrics ad Gynaecology Unit-II at Liaquat University of Medical and Health Sciences, Jamshoro. All postmenopausal women, admitted in the unit due to various pathologies (abdominal masses, bleeding P/V etc.) from January 2005 to December 2007 were included in the study. Clinical evaluation and investigations were done on all patients. Those women who had benign diseases were excluded from the study. Malignancy was confirmed from histopathology report of biopsy specimen. These women were divided into 3 age groups: group I 70 years. Results: Out of 265 postmenopausal women admitted in ward during the study period, malignancy was confirmed in 68 cases (25.66%). The type of malignancy was cervical carcinoma (41, 60.28%), ovarian carcinoma (11, 16.17%), endometrial carcinoma (8, 11.76%), vulval carcinoma (5, 7.35%) vaginal carcinoma (2, 2.94%), and leiomyosarcoma of uterus (1, 1.47%). Increased frequency of cervical and endometrial carcinomas were seen in Group-I cases, while vulval carcinoma was seen more commonly in Group-II cases ( p =0.004). Conclusion: A very high frequency of cervical carcinoma was seen in our patients. There is need for more public awareness to integrate routine Gynae-Pap screening. (author)

Synthesis of Cyclic Py-Im Polyamide Libraries

OpenAIRE

Li, Benjamin C.; Montgomery, David C.; Puckett, James W.; Dervan, Peter B.

2013-01-01

Cyclic Py-Im polyamides containing two GABA turn units exhibit enhanced DNA binding affinity, but extensive studies of their biological properties have been hindered due to synthetic inaccessibility. A facile modular approach toward cyclic polyamides has been developed via microwave-assisted solid-phase synthesis of hairpin amino acid oligomer intermediates followed by macrocyclization. A focused library of cyclic polyamides 1–7 targeted to the androgen response element (ARE) and the estrogen...

Experimentelle Untersuchungen zur sonographischen Frakturdiagnostik im Kinderalter

OpenAIRE

Meuser, Stefan Heinrich Peter

2010-01-01

Falsch diagnostiziert und nicht korrekt therapiert können Frakturen im Kindesalter zu Wachstumsstörungen und damit verbundenen lebenslangen Problemen führen. Nach einem Trauma ist die klinische Untersuchung und Bestimmung des Schmerzmaximums gerade bei Kindern oft sehr schwierig. So müssen häufig mehrere Röntgenaufnahmen getätigt werden, ehe eine Fraktur sicher diagnostiziert oder ausgeschlossen werden kann. Die hierbei auftretende ionisierende Strahlung geht jedoch besonder...

Simulation von Heißrubbeln im Gesamtbremssystem

OpenAIRE

Könning, Maximilian

2017-01-01

Bremsenrubbeln ist eine fremderregte Schwingung des Bremssystems, die es in der Ent-wicklung zu vermeiden gilt. Eine Wirkungskette des Heißrubbelns wurde in einem Vorgängerprojekt erarbeitet und bildet die Grundlage für diese Arbeit. Die Entstehung des Heißrubbelns besteht aus verschiedenen Phasen und beginnt mit einer initialen Verwellung. Daraus resultieren im Bremssystem Bremsmomentschwankungen und die schwankende Reibleistung führt wiederum zu einem Wachstum der Bremsscheibenverformung. ...

77 FR 12881 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

Science.gov (United States)

2012-03-02

... Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on February 6, 2012... seq. (``the Act''), IMS Global Learning Consortium, Inc. has filed written notifications..., Plano, TX; Keller ISD, Keller, TX; Maryland State Department of Education, Baltimore, MD; Measured...

77 FR 54611 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

Science.gov (United States)

2012-09-05

... Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on July 16, 2012... seq. (``the Act''), IMS Global Learning Consortium, Inc. has filed written notifications...; and Lightbox Education, Cheadle, UNITED KINGDOM, have withdrawn as parties to this venture. No other...

Synchronous Pulmonary Malignancies: Atypical Presentation of Mantle Cell Lymphoma Masking a Lung Malignancy.

Science.gov (United States)

Masha, Luke; Zinchuk, Andrey; Boosalis, Valia

2015-09-07

We present a case of a pleural space malignancy masked by an atypical presentation of mantle cell lymphoma. Our patient presented with a large pleural effusion and right sided pleural studding, initially attributed to a new diagnosis of mantle cell lymphoma. Rare atypical epithelial cells were also seen amongst the clonal population of lymphocytes. The patient lacked systemic manifestations of mantle cell lymphoma and did not improve with chemotherapy. A pleural biopsy ultimately revealed the presence of an undifferentiated carcinoma, favoring a lung primary. A discussion of synchronous pleural space malignancies involving lymphomas is given.

Detection of Atmospheric Explosions at IMS Monitoring Stations using Infrasound Techniques

National Research Council Canada - National Science Library

Christie, Douglas R; Kennett, Brian L; Tarlowski, Chris

2006-01-01

Work is continuing on the development of infrasound techniques that can be used to improve detection, location and discrimination capability for atmospheric nuclear explosions at International Monitoring System (IMS...

IMS2 – An integrated medical software system for early lung cancer detection using ion mobility spectrometry data of human breath

Directory of Open Access Journals (Sweden)

Baumbach Jan

2007-12-01

Full Text Available IMS2 is an Integrated Medical Software system for the analysis of Ion Mobility Spectrometry (IMS data. It assists medical staff with the following IMS data processing steps: acquisition, visualization, classification, and annotation. IMS2 provides data analysis and interpretation features on the one hand, and also helps to improve the classification by increasing the number of the pre-classified datasets on the other hand. It is designed to facilitate early detection of lung cancer, one of the most common cancer types with one million deaths each year around the world.

Beech tree analyses in the Bohemian/Austrian/Bavarian frontier region; Fallstudie Buche im Dreilaendereck Boehmen/Oberoesterreich/Bayern

Energy Technology Data Exchange (ETDEWEB)

Kirchner, M. [GSF - Forschungszentrum fuer Umwelt und Gesundheit GmbH, Muenchen (Germany). Inst. fuer Oekologische Chemie; Baumgarten, M.; Matyssek, R. [Muenchen Univ., Freising (DE). Lehrstuhl fuer Forstbotanik] [and others

2000-08-01

The condition of beech trees was investigated in six forest stands in the Bayerischer Wald and Boehmerwald mountains between 1995 and 1997 in order to establish the interdependence between tree conditions, the prevailing natural and anthropogenic site factors, and air pollution especially with groundlevel ozone. Details of the investigations are presented. Although a potential long-term effect of ozone cannot be excluded, the damage observed in beech trees in this region since the eighties is assumed to be caused not by a single factor but by complex interaction patterns between several anthropogenic and natural factors. [German] Es erfolgte im Untersuchungsgebiet Bayerischer Wald/Boehmerwald im Zeitraum 1995 bis 1997 eine detaillierte Zustandscharakterisierung von Altbuchen an sechs Standorten. Im Rahmen der Gesamtuntersuchung sollte geklaert werden, ob Zusammenhaenge zwischen dem Baumzustand und den herrschenden natuerlichen und anthropogenen Standortfaktoren und Luftbelastungen mit Schwerpunkt des bodennahen Ozons bestehen. An Hand kontinuierlicher Ozonmessungen konnte bestaetigt werden, dass die Konzentration des bodennahen Ozons im wesentlichen eine Funktion der Meereshoehe ist; somit ist an Hochlagenstandorten von hoeheren Immissionen auszugehen. Bei den moeglicherweise besser an photooxidativen Stress akklimatisierten Hochlagenbuchen waren die Schaeden bei erhoehter Ozonbelastung geringer ausgepraegt als bei Tieflagenbuchen. Fuer die Hypothese, wonach man eine staerkere Schaedigung der Hochlagenbestaende zu erwarten hat, wurde keine Bestaetigung gefunden. Inositol wird seit einiger Zeit als sensitiver Indikator diskutiert, der auf veraenderte Umweltbedingungen reagiert. Die Inositolkonzentration in Sonnenblaettern von Altbuchen im Bayerischen Wald war in 1995 um ca. 50% geringer als in 1996. Bei den Jungbuchen im Phytotronenexperiment kam es bei anhaltendem Ozonstress und zunehmender Schaedigung zu einer starken Reduktion der Inositolkonzentration in

Measurement of peripheral plasma using double probe in TRIAM-IM

International Nuclear Information System (INIS)

Yamagami, Masahiro; Kawasaki; Shoji; Jyotaki, Eriko; Fujita, Takaaki; Sakamoto, Mizuki; Nakamura, Kazuo; Nakamura, Yukio; Ito, Satoshi

1994-01-01

Behind the poloidal limiter of the TRIAM-IM, the change with time lapse of the electron temperature and the plasma density at the time of OH discharge was examined by using a double probe. Scrape-off plasma parameters, namely the correlations of electron temperature, plasma density and ion flux with main plasma parameters were obtained. It was found that scrape-off density is almost proportional to square of beam average electron density. Further, it was determined by calculation that the density on the outermost shell magnetic surface is about 1.5 x 10 15 /m 2 . In the TRIAM-IM, it is expected that accompanying the increase of plasma current at the time of OH discharge, the effects of thermal load and particle load given to the limiter and the first wall increase, and the increase of the metallic impurities due to sputtering becomes a serious problem. The merits of double probe method are explained. The objective of this experiment is to examine the temperature and density of the plasma that comes in contact with the limiter and the wall by determining the basic parameters of peripheral plasma at the time of OH discharge. In order to heighten the reliability of data, the examination was carried out from both aspects of hardware and software. The TRIAM-IM, double probe measuring system and its theory, applied voltage sweeping part, signal processing system, data processing system, and the experimental results of scrape-off layer parameters are described. (K.I.)

Collaborative Research: Calibration for IMS Stations in Eastern Asia

Science.gov (United States)

2007-07-01

Atomnaya Energia , Vol.87, Issue 3, 1989 (in Russian). 142 BondAr, I. Combining 1-D models for regional calibration, in Proceedings of a Workshop on IMS...Zelentsov and V.N. Mikhailov, Characteristics of 96 underground nuclear explosions at the Semipalatinsk Test Site, Atomaya Energia , (in Russian), Vol. 67

Sensorless Control of IM for Limp-Home Mode EV Applications

DEFF Research Database (Denmark)

Dehghan-Azad, Ehsan; Gadoue, Shady; Atkinson, David

2017-01-01

in electric vehicle (EV) applications. The proposed scheme was experimentally tested on a laboratory dynamometer using a 19-kW IM and a 29-kW controller, which are both currently used in the automotive industry for EV applications. The scheme was also implemented on an electric golf buggy which was equipped......This paper presents a novel speed estimation scheme for induction motors (IMs) based on back electromotive-force model reference adaptive system (back-EMF MRAS). The scheme is employed for the purpose of sensorless fault-Tolerant torque-controlled drives used in a limp-home mode operation...... investigated for vehicle starting from standstill, wide speed range including field weakening region, and hill-starting operations. The proposed scheme is computationally easy to implement, robust against sensitivity to parameters variations, inverter nonlinearity and errors due to digitization in the field...

[Molecular heterogeneity of malignant pleural mesotheliomas].

Science.gov (United States)

Tranchant, Robin; Montagne, François; Jaurand, Marie-Claude; Jean, Didier

2018-01-01

Malignant pleural mesothelioma (MPM) is predominantly an occupational cancer, most often linked to asbestos exposure. Malignant pleural mesothelioma prognosis is poor with a short survival median, due to the aggressiveness of tumor cells and the weak efficiency of conventional anti-cancer therapies. Clinical, histological, and molecular data suggest tumor heterogeneity between patients as it was also shown for other cancer types. Consequently, there is an urgent need to develop new therapies that take into account this heterogeneity and the molecular characteristics of malignant pleural mesothelioma, in particular by identifying new anti-cancer drugs targeting the molecular specificities of each malignant pleural mesothelioma. Malignant pleural mesothelioma is characterized by numerous molecular alterations at the chromosomal, genetic and epigenetic levels. Molecular classification based on gene expression profile has firstly defined two tumor groups, C1 and C2, and more recently, four groups. By integrating genetic and transcriptomic analysis, a C2 LN tumor subgroup of the C2 group has been identified and characterized. In addition to tumor heterogeneity between patients, intra-tumor heterogeneity is supported by several evidences. Most therapeutic strategies that take into account the tumor molecular characteristics have focused on targeted therapies based on mutated genes. A more appropriate strategy would be to consider better-defined tumor groups on the basis of several molecular alterations types as it has been proposed for the C2 LN subgroup. A robust definition of homogeneous tumor groups sharing common molecular characteristics is necessary for the development of effective precision medicine for malignant pleural mesothelioma. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

FUNKTIONSLOGIK TERRORISTISCHER PROPAGANDA IM BEWEGTEN BILD

Directory of Open Access Journals (Sweden)

Stefan Christoph

2015-09-01

Full Text Available Die Medienfront ist heute ein wichtiger Kriegsschauplatz, den viele neben Land, Wasser und Luft für gleich wichtig halten. Terroristen fühlen sich in sozialen Medien wohler als man denken könnte. Im Netz können sie die asymmetrische Kräfteverteilung überwinden, die sie in der offenen Feldschlacht unterlegen sein ließe. Terroristen machen sich das Bild zur Waffe und produzieren erst durch die Positionierung an der Medienfront Sinn in ihren Taten. Ohne ein Bekennerschreiben, ein Abschiedsvideo des Attentäters oder ein letztes Posting im sozialen Netzwerk wäre ein Bombenanschlag nichts als ein Kapitalverbrechen. Durch die terroristische Kommunikationsstrategie wird das Verbrechen erst zum terroristischen Akt. Das ist die theoretische Grundannahme dieses Aufsatzes. Ohne Medienberichterstattung könnten terroristische Organisationen nicht existieren. Durch die Entwicklung des Web 2.0 und insbesondere sozialer Medien kommen terroristische Organisationen heutzutage aber ganz ohne das Verschicken von Videotapes an Fernsehsender aus. Durch YouTube und andere Kanäle, können sie die Adressaten ihrer Botschaften direkt und ohne zwischengeschaltete Journalistinnen und Journalisten erreichen. So ist es nicht erstaunlich, dass terroristische Organisationen sich eine gewisse Expertise im Umgang mit sozialen Medien zugelegt haben. Al-Qaida hat seine eigene Medienabteilung, auch die kolumbianischen FARC arbeiten sehr professionell und welchen Einfluss der Islamische Staat im Internet ausübt ist inzwischen bereits Gegenstand einiger Reportagen und Untersuchungen geworden. Die diesem Aufsatz zugrundeliegende Arbeit hat sich mit neun verschiedenen Videos aus dem Umfeld von al-Qaida, der IRA und der FARC beschäftigt und versucht, aus dem analytischen Vergleich dieser Videos Rückschlüsse über terroristische Medienmacher und die terroristischen Organisationen selbst zu ziehen. Wie schnell und suggestiv die Videos arbeiten, ist etwa davon abh

75 FR 51114 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

Science.gov (United States)

2010-08-18

... Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on July 13, 2010... seq. (``the Act''), IMS Global Learning Consortium, Inc. has filed written notifications...; New York City Department of Education, New York, NY; and Ucompass.com , Inc., Tallahassee, FL, have...

76 FR 79217 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

Science.gov (United States)

2011-12-21

... Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on November 28....C. 4301 et seq. (``the Act''), IMS Global Learning Consortium, Inc. has filed written notifications..., have been added as parties to this venture. Also, Inclusive Design Research Center, Toronto, Ontario...

76 FR 34252 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; IMS Global...

Science.gov (United States)

2011-06-13

... Production Act of 1993; IMS Global Learning Consortium, Inc. Notice is hereby given that, on May 9, 2011... seq. (``the Act''), IMS Global Learning Consortium, Inc. has filed written notifications... Education, Hamar, Norway, have been added as parties to this venture. Also, CTUnion, Seoul, Republic of...

Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies

Directory of Open Access Journals (Sweden)

Hongyun Ma

2016-01-01

Full Text Available Malignant spinal tumors, categorized into primary and metastatic ones, are one of the most serious diseases due to their high morbidity and mortality rates. Common primary spinal tumors include chordoma, chondrosarcoma, osteosarcoma, Ewing’s sarcoma, and multiple myeloma. Spinal malignancies are not only locally invasive and destructive to adjacent structures, such as bone, neural, and vascular structures, but also disruptive to distant organs (e.g., lung. Current treatments for spinal malignancies, including wide resection, radiotherapy, and chemotherapy, have made significant progress like improving patients’ quality of life. Among them, chemotherapy plays an important role, but its potential for clinical application is limited by severe side effects and drug resistance. To ameliorate the current situation, various polymer nanoparticles have been developed as promising excipients to facilitate the effective treatment of spinal malignancies by utilizing their potent advantages, for example, targeting, stimuli response, and synergetic effect. This review overviews the development of polymer nanoparticles for antineoplastic delivery in the treatment of spinal malignancies and discusses future prospects of polymer nanoparticle-based treatment methods.

Minimal-change nephropathy and malignant thymoma.

Science.gov (United States)

Varsano, S; Bruderman, I; Bernheim, J L; Rathaus, M; Griffel, B

1980-05-01

A 56-year-old man had fever, precordial pain, and a mediastinal mass. The mass disappeared two months later and the patient remained asymptomatic for 2 1/2 years. At that time a full-blown nephrotic syndrome developed, with minimal-change glomerulopathy. The chest x-ray film showed the reappearance of a giant mediastinal mass. On biopsy of the mass, malignant thymoma was diagnosed. Association between minimal-change disease and Hodgkin's disease is well known, while the association with malignant thymoma has not been previously reported. The relationship between malignant thymoma and minimal-change disease is discussed, and a possible pathogenic mechanism involving cell-mediated immunity is proposed.

Modeling Myeloid Malignancies Using Zebrafish

Directory of Open Access Journals (Sweden)

Kathryn S. Potts

2017-12-01

Full Text Available Human myeloid malignancies represent a substantial disease burden to individuals, with significant morbidity and death. The genetic underpinnings of disease formation and progression remain incompletely understood. Large-scale human population studies have identified a high frequency of potential driver mutations in spliceosomal and epigenetic regulators that contribute to malignancies, such as myelodysplastic syndromes (MDS and leukemias. The high conservation of cell types and genes between humans and model organisms permits the investigation of the underlying mechanisms of leukemic development and potential therapeutic testing in genetically pliable pre-clinical systems. Due to the many technical advantages, such as large-scale screening, lineage-tracing studies, tumor transplantation, and high-throughput drug screening approaches, zebrafish is emerging as a model system for myeloid malignancies. In this review, we discuss recent advances in MDS and leukemia using the zebrafish model.

Malignant neurocristic hamartoma: a tumor distinct from conventional melanoma and malignant blue nevus.

Science.gov (United States)

Linskey, Katy R; Dias-Santagata, Dora; Nazarian, Rosalynn M; Le, Long P; Lam, Quynh; Bellucci, Kirsten S W; Robinson-Bostom, Leslie; Mihm, Martin C; Hoang, Mai P

2011-10-01

Neurocristic hamartomas are rare pigmented lesions comprised of melanocytes, Schwann cells, and pigmented dendritic spindle cells that involve the skin and soft tissue. Malignant transformation can rarely arise within neurocristic hamartomas. Up to date, there has been only 1 series of 7 cases of malignant neurocristic hamartomas (MNHs), with 3 cases that developed metastases. We present the histology and clinical course of 3 additional cases of MNH, 2 of which were metastatic. CD117 was strongly positive in all cases with available archival materials--the tumors and background neurocristic hamartoma of 3 cases, and 1 lymph node metastasis; however, KIT sequencing for exons 11, 13, 17, and 18 was negative. Mutational analyses of recurrent mutations of 17 cancer genes, including BRAF and KIT, were also negative. Although our series is small, KIT overexpression in MNH does not seem to correlate with gene mutation. The lack of BRAF, NRAS, GNAQ, and KIT mutations seems to support the notion that MNH may be distinct from conventional melanoma and from other dermal melanomas, such as malignant blue nevi and melanoma arising in congenital nevi.

Malignant Struma Ovarii

African Journals Online (AJOL)

Malignant Struma Ovarii: Case Report and a Review of the Literature. Philip CN Okere, Daniel ... uterus was grossly unremarkable. .... abnormal vaginal bleeding, ascites, hydrothorax our patient ... In: Somers SAC, Rosen MR, eds. Pathology.

Engineering and development projects for the sustainment and enhancement of the IMS infrasound network

Science.gov (United States)

Marty, J.; Martysevich, P.; Kramer, A.; Haralabus, G.

2012-04-01

The Provisional Technical Secretariat (PTS) of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) has a continuous interest in enhancing its capability in infrasound source localization and characterization. This capability is based on the processing of data recorded by the infrasound network of the International Monitoring System (IMS). This infrasound network consists of sixty stations, among which forty-five are already certified and continuously transmit data to the International Data Center (IDC) in Vienna, Austria. Each infrasound station is composed of an array of infrasound sensors capable of measuring micro-pressure changes produced at ground level by infrasonic waves. It is the responsibility of the Engineering and Development Section of the IMS Division to ensure the highest quality for IMS infrasound data. This includes the design of robust and reliable infrasound stations, the use of accurate and calibrated infrasound measuring chains, the installation of efficient wind noise reduction systems and the implementation of quality-control tools. The purpose of this paper is to present ongoing PTS infrasound engineering and development projects related to the testing and validation of wind noise reduction system models, the implementation of infrasound data QC tools, the definition of guidelines for the design of IMS power supply systems and the development of a portable infrasound calibrator and of field kits for site survey and certification.

40 CFR 51.352 - Basic I/M performance standard.

Science.gov (United States)

2010-07-01

... following model I/M program inputs and local characteristics, such as vehicle mix and local fuel controls... current version of the EPA mobile source emission model, and shall meet the minimum performance standard... specified in 40 CFR part 85, subpart W. (8) Emission control device inspections. None. (9) Stringency. A 20...

Dust abatement in mining and tunnelling - status report; Stand der Technik bei der Staubbekaempfung im Berg- und Tunnelbau

Energy Technology Data Exchange (ETDEWEB)

Mikki, P. [CFT GmbH, Compact-Filtertechnik, Gladbeck (Germany)

2005-02-01

Health and safety have priority in underground mining, especially dust and silicosis prevention in mining and tunnelling. While silicosis is not considered as an occupational disease in the strict sense, it is well known that most silicosis cases occur in these industries. (orig.) [German] Im Untertagebau sind die Probleme des Gesundheitsschutzes von vorrangiger Bedeutung, insbesondere im Bereich der Staub- und Silikosebekaempfung im Berg- und Tunnelbau. Wenn auch bei der Silikose nicht ausschliesslich von einer unter Tagespezifischen Berufskrankheit gesprochen werden kann, so entfaellt doch der ueberwiegende Teil der auftretenden Krankheitsfaelle auf diese Industriezweige. (orig.)

Images and society (or Images, Society and its Decoding Las imágenes y la sociedad (o las imágenes, la sociedad y su desciframiento

Directory of Open Access Journals (Sweden)

Juan Soto Ramírez

2012-11-01

Full Text Available

Common sense, the thinking of the people par excellence, asserts that: a picture is worth a thousand words. This is a big mistake. The images are not carriers of meanings. The images always go through three basic processes are: production, circulation and reception. These processes are always determined in the time and social space. They are always the result of multiple relationships (social, ideological, political, moral, religious, etc., established with them. Always there are so many elements beyond the image, which determines its meaning. The meaning of an image always depends on the relationships established with it in a historical time and space, socially and culturally determined. The images are never alone. To decrypt their meanings, you must first know the symbolic life of the societies in which they appear. Images do not have a single meaning because it depends on the historical and cultural geography which presents. The images always have a close relationship with the society they were born. The Muhammad cartoons not offend everyone equally.

El sentido común, que es el pensamiento de las colectividades por excelencia, afirma que: una imagen dice más que mil palabras. Lo cual es un grave error. Las imágenes no son portadoras de significados. Las imágenes siempre atraviesan por tres procesos básicos que son: su producción, su circulación y su recepción. Estos procesos siempre están determinados en el tiempo y en el espacio sociales. Su significado siempre es el resultado de múltiples relaciones (sociales, ideológicas, políticas, morales, religiosas, etc., que se establecen con las mismas. Es decir, siempre existen elementos que están más allá de la imagen, que determinan su significado. La manera en cómo se significa una imagen, siempre depende de las relaciones que se establecen con ella en un tiempo histórico y en un espacio, social y culturalmente determinado. Las imágenes nunca están solas. Para

The androgen receptor malignancy shift in prostate cancer.

Science.gov (United States)

Copeland, Ben T; Pal, Sumanta K; Bolton, Eric C; Jones, Jeremy O

2018-05-01

Androgens and the androgen receptor (AR) are necessary for the development, function, and homeostatic growth regulation of the prostate gland. However, once prostate cells are transformed, the AR is necessary for the proliferation and survival of the malignant cells. This change in AR function appears to occur in nearly every prostate cancer. We have termed this the AR malignancy shift. In this review, we summarize the current knowledge of the AR malignancy shift, including the DNA-binding patterns that define the shift, the transcriptome changes associated with the shift, the putative drivers of the shift, and its clinical implications. In benign prostate epithelial cells, the AR primarily binds consensus AR binding sites. In carcinoma cells, the AR cistrome is dramatically altered, as the AR associates with FOXA1 and HOXB13 motifs, among others. This shift leads to the transcription of genes associated with a malignant phenotype. In model systems, some mutations commonly found in localized prostate cancer can alter the AR cistrome, consistent with the AR malignancy shift. Current evidence suggests that the AR malignancy shift is necessary but not sufficient for transformation of prostate epithelial cells. Reinterpretation of prostate cancer genomic classification systems in light of the AR malignancy shift may improve our ability to predict clinical outcomes and treat patients appropriately. Identifying and targeting the molecular factors that contribute to the AR malignancy shift is not trivial but by doing so, we may be able to develop new strategies for the treatment or prevention of prostate cancer. © 2018 Wiley Periodicals, Inc.

Dose and dose rate extrapolation factors for malignant and non-malignant health endpoints after exposure to gamma and neutron radiation

Energy Technology Data Exchange (ETDEWEB)

Tran, Van; Little, Mark P. [National Cancer Institute, Radiation Epidemiology Branch, Rockville, MD (United States)

2017-11-15

Murine experiments were conducted at the JANUS reactor in Argonne National Laboratory from 1970 to 1992 to study the effect of acute and protracted radiation dose from gamma rays and fission neutron whole body exposure. The present study reports the reanalysis of the JANUS data on 36,718 mice, of which 16,973 mice were irradiated with neutrons, 13,638 were irradiated with gamma rays, and 6107 were controls. Mice were mostly Mus musculus, but one experiment used Peromyscus leucopus. For both types of radiation exposure, a Cox proportional hazards model was used, using age as timescale, and stratifying on sex and experiment. The optimal model was one with linear and quadratic terms in cumulative lagged dose, with adjustments to both linear and quadratic dose terms for low-dose rate irradiation (<5 mGy/h) and with adjustments to the dose for age at exposure and sex. After gamma ray exposure there is significant non-linearity (generally with upward curvature) for all tumours, lymphoreticular, respiratory, connective tissue and gastrointestinal tumours, also for all non-tumour, other non-tumour, non-malignant pulmonary and non-malignant renal diseases (p < 0.001). Associated with this the low-dose extrapolation factor, measuring the overestimation in low-dose risk resulting from linear extrapolation is significantly elevated for lymphoreticular tumours 1.16 (95% CI 1.06, 1.31), elevated also for a number of non-malignant endpoints, specifically all non-tumour diseases, 1.63 (95% CI 1.43, 2.00), non-malignant pulmonary disease, 1.70 (95% CI 1.17, 2.76) and other non-tumour diseases, 1.47 (95% CI 1.29, 1.82). However, for a rather larger group of malignant endpoints the low-dose extrapolation factor is significantly less than 1 (implying downward curvature), with central estimates generally ranging from 0.2 to 0.8, in particular for tumours of the respiratory system, vasculature, ovary, kidney/urinary bladder and testis. For neutron exposure most endpoints, malignant and

76 FR 18797 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

Science.gov (United States)

2011-04-05

... Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on March 3, 2011... seq. (``the Act''), IMS Global Learning Consortium, Inc. has filed written notifications... Centre for ICT in Education, Hamar, NORWAY, has been added as a party to this venture. Also, Horizon...

77 FR 34069 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

Science.gov (United States)

2012-06-08

... Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on May 2, 2012... seq. (``the Act''), IMS Global Learning Consortium, Inc. has filed written notifications... Education has changed its name to Ellucian, Malvern, PA. No other changes have been made in either the...

67Ga-citrate scanning in gastrointestinal malignancies

International Nuclear Information System (INIS)

Douds, H.N.; Berens, S.V.; Long, R.F.; Caplan, G.E.

1978-01-01

The value of 67 Ga-citrate scanning in cases of gastrointestinal malignancies is discussed. Seven cases are presented, including lymphomas of the stomach, small bowel, and rectum, and adenocarcinomas of the stomach and colon. In a review of the literature, there is general pessimism regarding the use of 67 Ga scans in GI malignancies. Based on previous reports and our own experience, specific clinical situations are cited in which the scan is of considerable value for diagnosis and followup of GI malignancy

"In allen guten Buchhandlungen ist zu haben". Buchwerbung in Deutschland im 17. und 18. Jahrhundert

OpenAIRE

Hauke, Marie-Kristin

2005-01-01

Der Buchhandel entwickelte im Laufe des 17. und 18. Jahrhunderts zahlreiche Hilfsmittel zur Absatzförderung, auf die er als Produzent des „Massenartikels“ Buch angewiesen war und die ihn zum Vorreiter der modernen Wirtschaftswerbung machten. Ausgangsbasis dafür waren die im 16. Jahrhundert entstandenen Werbemittel Buchtitel, Titelblatt und Katalog, die durch die Buchanzeigen in verschiedenen Werbeträgern (Zeitung, Zeitschrift, Intelligenzblatt, Buch) sowie einige kleinere Formen (Handzettel, ...

Skull infarction in a patient with malignant fibrous histiocytoma.

Science.gov (United States)

Nagle, C E; Morayati, S J; LeDuc, M A

1987-09-01

The authors describe a case of a skull infarction initially suspected to be an isolated, remote metastasis in a patient diagnosed with soft tissue malignant fibrous histiocytoma. Osseous malignant fibrous histiocytoma has been reported to occur within a bone infarction but the presence of a benign bone infarction remote from a soft tissue malignant fibrous histiocytoma has not been reported previously. Bone infarctions and malignant fibrous histiocytomas are briefly reviewed.

Im Bild sprechen: Cixous Visual Instruction: Cixous

OpenAIRE

Jens E. Sennewald

2006-01-01

Gemeinsam von Künstlern und Wissenschaftlern/Philosophen erstellte Bücher sind selten und nicht immer erfolgreich. Eines der Fährnisse ist das Verhältnis zwischen bildlichen und schriftlichen Anteilen: Nicht selten wird der künstlerische Anteil zur Illustration der dominierenden Schrift. Eine Neupositionierung des Bildes im Buch ist nun der amerikanischen Künstlerin Roni Horn gelungen. Mehr als „sujet“ ihres Buches, ist die französische Philosophin Hélène Cixous gleichsam instruierende „Stimm...

Corporate Venture Capital im Bankensektor: Eine Fallstudie

OpenAIRE

Maxin, Hannes

2015-01-01

Die Digitalisierung der Gesellschaft beeinflusst zunehmend das klassische Bankgeschäft, was durch die Erfolge vieler junger FinTech-Unternehmen verdeutlicht wird. Der damit verbundene Innovationsdruck führte dazu, dass die Commerzbank AG im Oktober 2013 die Main Incubator GmbH gründete. Mithilfe dieser Corporate Venture Capital-Gesellschaft (CVC-Gesellschaft) versucht die Frankfurter Großbank, eine Kooperation mit den neuen Wettbewerbern einzugehen, um mögliche Synergiepotenziale für das eige...

Asbestos-related malignancy

International Nuclear Information System (INIS)

Antmann, K.; Aisner, J.

1986-01-01

This book contains 20 chapters. Some of the chapter titles are: The Radiology of Asbestosis and Related Neoplasms; Computed Tomography and Malignant Mesothelioma; Radiation Therapy for Pleural Mesothelioma; and Radiation Therapy of Peritoneal Mesothelioma

Localized malignant pleural mesothelioma: report of two cases.

Science.gov (United States)

Tanzi, Silvia; Tiseo, Marcello; Internullo, Eveline; Cacciani, Giancarlo; Capra, Roberto; Carbognani, Paolo; Rusca, Michele; Rindi, Guido; Ardizzoni, Andrea

2009-08-01

Localized malignant pleural mesothelioma is very rare tumor disease. There are sporadic reports in the literature showing that this entity has a different biologic behavior compared with diffuse pleural mesothelioma. We report two cases of radically resected localized pleural malignant mesothelioma, with a previous history of asbestos exposure. Both cases showed a microscopic and immunohistochemical findings of malignant mesothelioma, biphasic and sarcomatoid lympho-histiocitoid variant type, respectively, without evidence of diffuse pleural spread. The first is very peculiar case of bilateral localized malignant pleural mesothelioma with complete response to chemotherapy and localized late recurrence, radically resected and treated with adjuvant radiotherapy. The second case revealed as a solitary localized mass, underwent a complete en bloc resection and adjuvant radiotherapy. Both cases demonstrate that the localized malignant mesothelioma should be distinguished from diffuse form and that complete resection is associated with good prognosis.

Federal Workforce: Attrition Rates at Ex-Im Bank and Similar Agencies

National Research Council Canada - National Science Library

Hess, James

1997-01-01

.... Financing and protection provided by Ex-Im Bank includes (1) loans to foreign buyers of U.S. exports, (2) loan guarantees to commercial lenders providing repayment protection for loans to foreign buyers...

HRCT patterns of the most important interstitial lung diseases; HRCT-Muster der wichtigsten interstitiellen Lungenerkrankungen

Energy Technology Data Exchange (ETDEWEB)

Schaefer-Prokop, C. [Meander Medisch Centrum, Abt. Radiologie, Amersfoort (Netherlands); Radboud Universitaet, Abt. Radiologie und Nuklearmedizin, Nijmegen (Netherlands)

2014-12-15

Interstitial lung diseases are a mixed group of diffuse parenchymal lung diseases which can have an acute or chronic course. Idiopathic diseases and diseases with an underlying cause (e.g. collagen vascular diseases) share the same patterns. Thin section computed tomography (CT) plays a central role in the diagnostic work-up. The article describes the most important interstitial lung diseases following a four pattern approach with a predominant nodular or reticular pattern or a pattern with increased or decreased lung density. (orig.) [German] Interstitielle Lungenerkrankungen stellen eine gemischte Gruppe diffuser Lungenparenchymerkrankungen dar, die einen akuten oder chronischen Verlauf haben koennen. Idiopathische Erkrankungen und Erkrankungen mit definierter Ursache (z. B. kollagenvaskulaere Erkrankungen) weisen ein gemeinsames Muster auf. Die Duennschichtcomputertomographie spielt eine zentrale Rolle in der diagnostischen Abklaerung. In dem vorliegenden Beitrag werden die wichtigsten interstitiellen Lungenerkrankungen beschrieben. Dabei gibt es 4 Grundmuster: ueberwiegend nodulaere Verdichtungen, vorwiegend retikulaere Verdichtungen, erhoehte oder erniedrigte Lungenparenchymdichte. (orig.)

INSTANT MESSENGER (IM) APPLICATION USAGE AT WORKPLACE AND WORKING CULTURE OF A PUBLIC UNIVERSITY SUPPORTING STAFF IN KOTA KINABALU SABAH.

OpenAIRE

Nading, Dorina; Morshidi, Azizan

2016-01-01

Instant Messenger (IM) has becoming a new form of social relations tool in which people interact, dialogue, collaborate and exchange information. Many organizations and companies have adapted their management strategies with the utilization of IM applications, both internally or externally. The popularity of IM in local organizational management in such a way that government agencies, companies, universities, colleges and schools. The use of applications such as wechat, whatsApp messenger...

Synchronous pulmonary malignancies: atypical presentation of mantle cell lymphoma masking a lung malignancy

Directory of Open Access Journals (Sweden)

Luke Masha

2015-09-01

Full Text Available We present a case of a pleural space malignancy masked by an atypical presentation of mantle cell lymphoma. Our patient presented with a large pleural effusion and right sided pleural studding, initially attributed to a new diagnosis of mantle cell lymphoma. Rare atypical epithelial cells were also seen amongst the clonal population of lymphocytes. The patient lacked systemic manifestations of mantle cell lymphoma and did not improve with chemotherapy. A pleural biopsy ultimately revealed the presence of an undifferentiated carcinoma, favoring a lung primary. A discussion of synchronous pleural space malignancies involving lymphomas is given.

Agrupador de imágenes multimodal no supervisado

OpenAIRE

Pérez Hernando, Jesús

2013-01-01

Trabajo Fin de Máster donde se implementa un método multimodal para la clasificación de imágenes sin etiquetar y sin intervención humana. Treball Fi de Màster on s'implementa un mètode multimodal per a la classificació d'imatges sense etiquetar i sense intervenció humana. Master thesis for the Computer Science Engineering program.

Clinical diagnosis of malignant pleural mesothelioma

International Nuclear Information System (INIS)

Nishi, Hideyuki; Washio, Kazuhiro; Mano, Masayuki

2008-01-01

We evaluated clinical and thoracoscopic findings of cases that underwent thoracoscopic biopsy for the diagnosis of malignant pleural mesothelioma. We reviewed 32 cases suspected of having malignant pleural mesothelioma from 2003 to 2006. We made a diagnosis of malignant pleural mesothelioma via thoracoscopic biopsy (19 cases). The cut-off level of hyaluronic acid in malignant effusions, selected on the basis of the best diagnostic efficacy, was 100 μg/ml. We can decrease the incidence of false negative cases by the combination of CT findings and the presence of hyaluronic acid in pleural effusion. In the pleural thickening type of thoracoscopic appearance, the parietal pleurae were thickened, and small nodules were rare. As for this type, tumor cells were histologically absent or confined to the submesothelial tissue. We considered that determinations of specific sites were difficult. Adequate tissue samples obtained via video-assisted thoracoscopy were necessary for diagnosis. We can decrease the incidence of false negative cases by the combination of the presence of hyaluronic acid in pleural effusion and thoracoscopic biopsy. (author)

Detection of liver lesions with gadolinium-enhanced VIBE sequence in comparison with SPIO-enhanced MRI; Detektion von Leberlaesionen mit der Gadolinium-verstaerkten VIBE-Sequenz im Vergleich zur SPIO-verstaerkten MRT

Energy Technology Data Exchange (ETDEWEB)

Heim, P.; Steiner, P.; Dieckmann, C.; Adam, G. [Universitaetsklinikum Hamburg-Eppendorf (Germany). Klinik und Poliklinik fuer Diagnostische und Interventionelle Radiologie; Schoder, V. [Universitaetsklinikum Hamburg-Eppendorf (Germany). Inst. fuer Medizinische Biometrie und Epidemiologie; Kuhlencordt, R. [Universitaetsklinikum Hamburg-Eppendorf (Germany). Klinik und Poliklinik fuer Allgemein-, Viszeral-, und Thoraxchirurgie

2003-10-01

Purpose: Detection of malignant liver lesions with gadolinium-enhanced volumetric interpolated breath-hold examination (VIBE) in comparison with SPIO-enhanced MRT (four different SPIO-enhanced T2w sequences) and histological and imaging follow-up in non-cirrhotic livers at 1.5 T. Patients and methods: Twenty-two patients with suspected focal liver lesions prospectively underwent a gadolinium-enhanced 3D VIBE. Four T2w sequences (HASTE sequence, fast spin-echo-sequence with and without fat-saturation, FLASH 2D gradient echo-sequence) after administration of superparamagnetic iron oxide (SPIO) served as gold standard combined with histological work-up in 17 patients and histological and imaging follow-up in five patients. The image quality was evaluated and the detectability of intrahepatic lesions was rated by the alternative free-response receiver operating characteristic (AFROC) analysis. In addition, the contrast-to-noise ration was compared. Results: Altogether 49 malignant and 35 benign liver lesions were found. Concerning the image quality, VIBE turned out to be of slightly poorer image quality than the SPIO-enhanced examination with HASTE sequence (4.95 vs. 5.0). The fast spin-echo-sequence without fat-saturation demonstrated the highest contrast-to-noise ratio. All sequences showed a comparable certainty in detecting lesion (area under the curve 0.68-0.74) and identifying malignant liver lesions. Conclusions: Despite the small number of patients, VIBE seems to be a comparable, inexpensive and fast method in diagnosing malignant liver lesions. (orig.) [German] Ziel: Detektion maligner Leberlaesionen mit der Gadolinium-verstaerkten 3D-Gradientenecho-Sequenz in Atemanhaltetechnik (VIBE-Sequenz) im Vergleich mit der SPIO-verstaerkten MRT (vier verschiedene SPIO-verstaerkte T2-gew. Sequenzen) sowie histologischen und bildgebenden (Verlaufs-) Untersuchungen in nicht-zirrhotischen Lebern bei 1,5 T. Patienten und Methoden: 22 Patienten mit Verdacht auf maligne

MATTHEW'S SITZ IM LEBEN AND THE EMPHASIS ON THE TORAH

African Journals Online (AJOL)

Acta Theologica ... such as would be expected from letters (Bauckham 1998:48). Yet the ... it in other words; the Sitz im Leben der alten Kirche can indirectly be .... 4 Along with most scholars I assume that Matthew was written some time after.

Origin of malignant tumors of the upper respiratory and digestive tracts and the ear. Pt. 4. Malignant tumors caused by irradiation. B. Special part

Energy Technology Data Exchange (ETDEWEB)

Leicher, H [Mainz Univ. (Germany, F.R.). Hals-, Nasen- und Ohrenklinik

1979-12-01

The problem of radiation induced tumors is explained in detail in the following chapters: 1. Malignant tumors in dial painters using luminous paint, 2. Malignant tumors after injection of Thorotrast, 3. Bronchial tumors in Uran-mineworkers, 4. Malignant tumors caused by radium-compresses and radium-moulages, 5. Thyroid cancer caused by irradiation, 6. Leukemia and malignant tumors following the atomic bomb detonation in Hiroshima and Nakasaki, 7. Malignant tumors in Lupus vulgaris, 8. Development of malignant tumors following the irradiation of praecancerous alterations, of benign tumors and other benign changes in head and neck, 9. Radiation induced soft-tissue and bone sarcoma in the skull, 10. Radiation-induced cancers in hypopharynx diverticula, 11. Radiation-induced cancers in the antethoracic skin graft esophagus, 12. Radiation-induced second-tumors, 13. Cancer caused by ultraviolet rays, 14. Increase of hematogenic metastases by irradiation. 15. Malignant tumors caused by irradiation of the fetus in utero.

Eosinophilic Dermatosis of Hematologic Malignancy.

Science.gov (United States)

Lucas-Truyols, S; Rodrigo-Nicolás, B; Lloret-Ruiz, C; Quecedo-Estébanez, E

Dermatosis characterized by tissue eosinophilia arising in the context of hematologic disease is known as eosinophilic dermatosis of hematologic malignancy. The most commonly associated malignancy is chronic lymphocytic leukemia. Eosinophilic dermatosis of hematologic malignancy is a rare condition with a wide variety of clinical presentations, ranging from papules, erythematous nodules, or blisters that simulate arthropod bites, to the formation of true plaques of differing sizes. Histology reveals the presence of abundant eosinophils. We present 4 new cases seen in Hospital Arnau de Vilanova, Valencia, during the past 7 years. Three of these cases were associated with chronic lymphocytic leukemia and 1 with mycosis fungoides. It is important to recognize this dermatosis as it can indicate progression of the underlying disease, as was the case in 3 of our patients. Copyright © 2017 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.

Bluetooth in the car: chances and limits; Bluetooth im Auto: Moeglichkeiten und Grenzen

Energy Technology Data Exchange (ETDEWEB)

Hascher, W.

2000-06-01

Car manufacturers, electronic suppliers and research institutions such as the MIT in the U.S. everywhere work on complementing or replaced the wiring harness by radio links. One way of doing this is ''Bluetooth'', a short-distance-radio technology on the 2.4GHz-band.(orig.). [German] Weltweit wird in den Automobilkonzernen, bei den Elektronik-Zulieferfirmen und in Forschungseinrichtungen (z.B. beim MIT in den USA) daran gearbeitet, den 'Kabelbaum' im Kfz durch Funkverbindungen zu ergaenzen bzw. Teile davon zu ersetzen. Eine Loesung hierfuer ist 'Bluetooth', eine Kurzstrecken-Funktechnologie im 2,4-GHz-Band. (orig.)

Proteomic study of benign and malignant pleural effusion.

Science.gov (United States)

Li, Hongqing; Tang, Zhonghao; Zhu, Huili; Ge, Haiyan; Cui, Shilei; Jiang, Weiping

2016-06-01

Lung adenocarcinoma can easily cause malignant pleural effusion which was difficult to discriminate from benign pleural effusion. Now there was no biomarker with high sensitivity and specificity for the malignant pleural effusion. This study used proteomics technology to acquire and analyze the protein profiles of the benign and malignant pleural effusion, to seek useful protein biomarkers with diagnostic value and to establish the diagnostic model. We chose the weak cationic-exchanger magnetic bead (WCX-MB) to purify peptides in the pleural effusion, used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) to obtain peptide expression profiles from the benign and malignant pleural effusion samples, established and validated the diagnostic model through a genetic algorithm (GA) and finally identified the most promising protein biomarker. A GA diagnostic model was established with spectra of 3930.9 and 2942.8 m/z in the training set including 25 malignant pleural effusion and 26 benign pleural effusion samples, yielding both 100 % sensitivity and 100 % specificity. The accuracy of diagnostic prediction was validated in the independent testing set with 58 malignant pleural effusion and 34 benign pleural effusion samples. Blind evaluation was as follows: the sensitivity was 89.6 %, specificity 88.2 %, PPV 92.8 %, NPV 83.3 % and accuracy 89.1 % in the independent testing set. The most promising peptide biomarker was identified successfully: Isoform 1 of caspase recruitment domain-containing protein 9 (CARD9), with 3930.9 m/z, was decreased in the malignant pleural effusion. This model is suitable to discriminate benign and malignant pleural effusion and CARD9 can be used as a new peptide biomarker.

Malignant mesothelioma in situ.

Science.gov (United States)

Churg, Andrew; Hwang, Harry; Tan, Larry; Qing, Gefei; Taher, Altaf; Tong, Amy; Bilawich, Ana M; Dacic, Sanja

2018-05-01

The existence of malignant mesothelioma in situ (MIS) is often postulated, but there are no accepted morphological criteria for making such a diagnosis. Here we report two cases that appear to be true MIS on the basis of in-situ genomic analysis. In one case the patient had repeated unexplained pleural unilateral effusions. Two thoracoscopies 9 months apart revealed only visually normal pleura. Biopsies from both thoracoscopies showed only a single layer of mildly reactive mesothelial cells. However, these cells had lost BRCA1-associated protein 1 (BAP1) and showed loss of cyclin-dependent kinase inhibitor 2 (CDKN2A) (p16) by fluorescence in-situ hybridisation (FISH). NF2 was not deleted by FISH but 28% of the mesothelial cells showed hyperploidy. Six months after the second biopsy the patient has persisting effusions but no evidence of pleural malignancy on imaging. The second patient presented with ascites and minimal omental thickening on imaging, but no visual evidence of tumour at laparoscopy. Omental biopsy showed a single layer of minimally atypical mesothelial cells with rare tiny foci of superficial invasion of fat. BAP1 immunostain showed loss of nuclear BAP1 in all the surface mesothelial cells and the invasive cells. There was CDKN2A deletion, but no deletion of NF2 by FISH. These cases show that morphologically bland single-layered surface mesothelial proliferations with molecular alterations seen previously only in invasive malignant mesotheliomas exist, and presumably represent malignant MIS. More cases are need to understand the frequency of such changes and the time-course over which invasive tumour develops. © 2018 John Wiley & Sons Ltd.

8-dimensional lattice optimized formats in 25-GBaud/s VCSEL based IM/DD optical interconnections

DEFF Research Database (Denmark)

Lu, Xiaofeng; Tafur Monroy, Idelfonso

2015-01-01

Temporally combined 4- and 8-dimensional lattice grids optimized modulation formats for VCSEL based IM/DD short-reach optical inter-connections has been proposed and investigated numerically together with its conventional counterpart PAM-4. © 2015 OSA.......Temporally combined 4- and 8-dimensional lattice grids optimized modulation formats for VCSEL based IM/DD short-reach optical inter-connections has been proposed and investigated numerically together with its conventional counterpart PAM-4. © 2015 OSA....

Precise outage analysis of mixed RF/unified-FSO DF relaying with HD and 2 IM-DD channel models

KAUST Repository

Al-Ebraheemy, Omer Mahmoud S.

2017-07-20

This paper derives and analyzes the outage probability of mixed radio frequency (RF)/unified free space optical (FSO) dual-hop decode-and-forward (DF) relaying scheme, where heterodyne detection (HD) and intensity modulation-direct detection (IM-DD) are considered for FSO detection. In doing that, we correctly utilize, for the first time to the best of our knowledge, a precise channel capacity result for the IM-DD channel. Moreover, this is the first time that not only the (IM-DD input-independent) but also the (IM-DD cost-dependent) AWGN channel is considered in such system analysis. This work assumes that the first hop (RF link) follows Naka-gami-m fading, while the second hop (FSO link) follows Málaga (M) turbulence with pointing error. These fading and turbulence models include other ones (such as Rayleigh fading and Gamma-Gamma turbulence) as special cases, so our analysis can be considered as a generalized one from both RF and FSO fading models point of view. Additionally, the system outage probability is investigated asymptotically in high signal-to-noise ratio (SNR) regime, where a new non-reported diversity order and coding gain analysis are shown. Interestingly, we find that in the FSO hop, based on SNR, the HD or IM-DD cost-dependent results in a same diversity order which is twice the one of IM-DD input-independent. However, based on transmitted power all these FSO detectors result in a same diversity order. Furthermore, we offer simulation results which confirm the derived exact and asymptotic expressions.

Precise outage analysis of mixed RF/unified-FSO DF relaying with HD and 2 IM-DD channel models

KAUST Repository

Al-Ebraheemy, Omer Mahmoud S.; Salhab, Anas M.; Chaaban, Anas; Zummo, Salam A.; Alouini, Mohamed-Slim

2017-01-01

This paper derives and analyzes the outage probability of mixed radio frequency (RF)/unified free space optical (FSO) dual-hop decode-and-forward (DF) relaying scheme, where heterodyne detection (HD) and intensity modulation-direct detection (IM-DD) are considered for FSO detection. In doing that, we correctly utilize, for the first time to the best of our knowledge, a precise channel capacity result for the IM-DD channel. Moreover, this is the first time that not only the (IM-DD input-independent) but also the (IM-DD cost-dependent) AWGN channel is considered in such system analysis. This work assumes that the first hop (RF link) follows Naka-gami-m fading, while the second hop (FSO link) follows Málaga (M) turbulence with pointing error. These fading and turbulence models include other ones (such as Rayleigh fading and Gamma-Gamma turbulence) as special cases, so our analysis can be considered as a generalized one from both RF and FSO fading models point of view. Additionally, the system outage probability is investigated asymptotically in high signal-to-noise ratio (SNR) regime, where a new non-reported diversity order and coding gain analysis are shown. Interestingly, we find that in the FSO hop, based on SNR, the HD or IM-DD cost-dependent results in a same diversity order which is twice the one of IM-DD input-independent. However, based on transmitted power all these FSO detectors result in a same diversity order. Furthermore, we offer simulation results which confirm the derived exact and asymptotic expressions.

Thoracic computed tomography in patients with suspected malignant pleural effusions

International Nuclear Information System (INIS)

Traill, Zoee C.; Davies, Robert J.O.; Gleeson, Fergus V.

2001-01-01

AIM: To assess the role of contrast-enhanced computed tomography (CT) prospectively in patients with suspected malignant pleural effusions. MATERIALS AND METHODS: Forty consecutive patients referred for the investigation of a suspected malignant pleural effusion had contrast-enhanced thoracic CT, thoracoscopy, thoraco-centesis and pleural biopsy, either percutaneously or at thoracoscopy. Final diagnoses were based on histopathological or cytological analysis (n = 30), autopsy findings (n = 3) or clinical follow-up (n = 7). The pleural surfaces were classified at contrast-enhanced CT as normal or abnormal and, if abnormal, as benign or malignant in appearance using previously established CT criteria for malignant pleural thickening by two observers unaware of the pathological diagnosis. RESULTS: Pleural effusions were malignant in 32 patients and benign in eight patients. Pleural surfaces assessed at CT showed features of malignancy in 27 out of 32 patients with a malignant effusion (sensitivity 84%, specificity 100%). Overall, CT appearances indicated the presence of malignancy in 28 of 32 (87%) patients. All eight patients with benign pleural disease were correctly diagnosed by CT. CONCLUSION: Contrast-enhanced CT is of value in patients with suspected malignant pleural effusions. The previously established criteria for malignant pleural thickening of nodularity, irregularity and pleural thickness >1 cm are reliable in the presence of a pleural effusion. Traill, Z.C. et al. (2001)

Differential CT features between malignant mesothelioma and pleural metastasis from lung cancer or extra thoracic primary tumor mimicking malignant mesothelioma

Energy Technology Data Exchange (ETDEWEB)

Lee, Sung Il; Ryu, Young Hoon; Lee, Kwang Hun; Choe, Kyu Ok; Kim, Sang Jin [College of Medicine, Yonsei University, Seoul (Korea, Republic of)

2000-01-01

To evaluate the differential CT features found among malignant mesothelioma and pleural metastasis from lung cancer and from extra-thoracic primary tumor which on CT mimic malignant mesothelioma. Forty-four patients who on chest CT scans showed pleural thickening suggesting malignant pleural disease and in whom this condition was pathologically confirmed were included in this study. On the basis of their pathologically proven primary disease (malignant mesothelioma (n=3D14), pleural metastasis of lung cancer (n=3D18), extra thoracic primary tumor (n=3D12). They were divided into three groups. Cases of lung which on CT showed a primary lung nodule or endobronchial mass with pleural lesion, or manifested only pleural effusion, were excluded. The following eight CT features were retrospectively analyzed: (1) configuration of pleural lesion (type I, single or multiple separate nodules, type II, localized flat pleural thickening, type III, diffuse flat pleural thickening; type IV, type III with pleural nodules superimposed; type V, mass filling the hemithorax), (2) the presence of pleural effusion, (3) chest wall or rib invasion, (4) the involvement of a major fissure, (5) extra-pleural fat proliferation, (6) calcified plaque, (7) metastatic lymph nodes, (8) metastatic lung modules. In malignant mesothelioma, type IV (8/14) or II (4/14) pleural thickening was relatively frequent. Pleural metastasis of lung cancer favored type IV (8/18) or I (6/18) pleural thickening, while pleural metastasis from extrathoracic primary tumor showed a variable thickening configuration, except type V. Pleural metastasis from lung cancer and extrapleural primary tumor more frequently showed type I configuration than did malignant mesothelioma, and there were significant differences among the three groups. Fissural involvement, on the other hand, was significantly more frequent in malignant mesothelioma than in pleural metastasis from lung cancer or extrapleural primary tumor. Metastatic

Classification of malignant lymphomas

International Nuclear Information System (INIS)

Schneider, M.; Thyss, A.

1986-01-01

Malignant lymphomas, primary tumors of the lymphoid tissues, were first described in 1832 by Thomas Hodgkin. The histological characteristics were later defined by Sternberg and Reed, and Virchow introduced the concept of lymphosarcoma in 1863. Today, these pathologies are grouped together under the synonymous terms hematosarcoma or malignant lymphoma, which are in turn divided into Hodgkin's disease (HD) and non-Hodgkin's malignant lymphomas (NHL). The therapy of lymphomas is controversial. The validity of treatment for asymptomatic patients is questioned, owing to the indolent course of many lymphomas. Results for histologically unfavorable forms are highly disparate. Exclusive radiotherapy has occasionally produced up to 78% disease-free survival at 5 years for truly localized stages. Today, however, use of chemotherapy/radiotherapy combinations is almost universal, with chemotherapy occasionally being used alone and providing 90% disease-free survival at 5 years. Chemotherapy is the main treatment for disseminated forms; the major associations include doxorubicin hydrochloride (Adriamycin), cyclophosphamide, vincristine sulfate, methotrexate, and prednisone. Radiotherapy is used more for adjuvant purposes. Synthesis of recent studies allows us to reasonably expect 40% relapse-free survival at 10 years and the establishment of a cure plateau in the near future

Incidental findings in chest X-rays; Zufallsbefunde im Roentgenthorax

Energy Technology Data Exchange (ETDEWEB)

Wielpuetz, M.O.; Kauczor, H.U. [Universitaetsklinikum Heidelberg, Klinik fuer Diagnostische und Interventionelle Radiologie, Heidelberg (Germany); Universitaet Heidelberg, Translational Lung Research Center (TLRC), Deutsches Zentrum fuer Lungenforschung (DZL), Heidelberg (Germany); Universitaetsklinikum Heidelberg, Klinik fuer Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik, Heidelberg (Germany); Weckbach, S. [Universitaetsklinikum Heidelberg, Klinik fuer Diagnostische und Interventionelle Radiologie, Heidelberg (Germany); Universitaet Heidelberg, Translational Lung Research Center (TLRC), Deutsches Zentrum fuer Lungenforschung (DZL), Heidelberg (Germany)

2017-04-15

Conventional projection radiography (chest x-ray) is one of the most frequently requested procedures in radiology. Even though chest x-ray imaging is frequently performed in asymptomatic patients for preoperative assessment, clinically relevant incidental findings are relatively scarce. This is due to the relatively low sensitivity of chest x-rays where few clinically relevant incidental findings are to be expected, as any detectable pathologies will as a rule already be clinically symptomatic. Recommendations from relevant societies for the management of incidental findings, apart from the clarification of incidental nodules, do not exist. This review article therefore describes the most frequent and typical incidental findings of lung parenchyma (apart from pulmonary nodules), mediastinal structures including the hilum of the lungs, pleura, chest wall and major vessels. Also described are those findings which can be diagnosed with sufficient certainty from chest x-rays so that further clarification is not necessary and those which must be further clarified by multislice imaging procedures or other techniques. (orig.) [German] Eine der haeufigsten Untersuchungen in der Radiologie ist die konventionelle Projektionsradiographie des Thorax (Roentgenthorax). Auch wenn projektionsradiographische Aufnahmen im Rahmen einer praeoperativen Abklaerung haeufig als orientierende Untersuchung angefertigt werden, sind - bedingt durch die relativ geringe Sensitivitaet des Roentgenthorax - wenig klinisch relevante Zufallsbefunde zu erwarten, da nachweisbare Pathologien in der Regel bereits auch klinisch apparent sind. Empfehlungen entsprechender Fachgesellschaften zu Zufallsbefunden im Roentgenthorax jenseits der Abklaerung von Rundherden liegen nicht vor. Die vorliegende Arbeit beleuchtet daher haeufige und typische Zufallsbefunde des Lungenparenchyms (ausser den Lungenrundherden), der mediastinalen Strukturen einschliesslich der Hili, der Pleura, der Thoraxwand sowie der

MALIGNANCY IN LARGE COLORECTAL LESIONS

Directory of Open Access Journals (Sweden)

Carlos Eduardo Oliveira dos SANTOS

2014-09-01

Full Text Available Context The size of colorectal lesions, besides a risk factor for malignancy, is a predictor for deeper invasion Objectives To evaluate the malignancy of colorectal lesions ≥20 mm. Methods Between 2007 and 2011, 76 neoplasms ≥20 mm in 70 patients were analyzed Results The mean age of the patients was 67.4 years, and 41 were women. Mean lesion size was 24.7 mm ± 6.2 mm (range: 20 to 50 mm. Half of the neoplasms were polypoid and the other half were non-polypoid. Forty-two (55.3% lesions were located in the left colon, and 34 in the right colon. There was a high prevalence of III L (39.5% and IV (53.9% pit patterns. There were 72 adenomas and 4 adenocarcinomas. Malignancy was observed in 5.3% of the lesions. Thirty-three lesions presented advanced histology (adenomas with high-grade dysplasia or early adenocarcinoma, with no difference in morphology and site. Only one lesion (1.3% invaded the submucosa. Lesions larger than 30 mm had advanced histology (P = 0.001. The primary treatment was endoscopic resection, and invasive carcinoma was referred to surgery. Recurrence rate was 10.6%. Conclusions Large colorectal neoplasms showed a low rate of malignancy. Endoscopic treatment is an effective therapy for these lesions.

Broken Bar Fault Detection in IM Operating Under No-Load Condition

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RELJIC, D.

2016-11-01

Full Text Available This paper presents a novel method for broken rotor bar detection in a squirrel-cage induction motor (IM. The proposed method applies a single-phase AC voltage as a test signal on motor terminals, resulting in a stator backward-rotating magnetic field. The field ultimately causes additional current components in the stator windings whose magnitudes depend on the broken bar fault severity, even if the motor is unloaded. This allows robust broken bar fault detection based only on standard motor current signature analysis (MCSA technique. The proposed fault detection method is at first verified via simulations, using an IM model based on finite element analysis (FEA and multiple coupled circuit approach (MCCA. The subsequent experimental investigations have shown good agreement with both theoretical predictions and simulation results.

Sixteenth Meeting of the IMS Study Group "Cantus Planus"

Czech Academy of Sciences Publication Activity Database

Vozková, Jana

2011-01-01

Roč. 48, 2-3 (2011), s. 310-311 ISSN 0018-7003. [Sixteenth Meeting of the IMS Study Group “Cantus Planus”. Vídeň, 21.08.2011–27.08.2011] Institutional research plan: CEZ:AV0Z90580513 Keywords : plainchant * annual conference * International Musicological Society Subject RIV: AL - Art, Architecture, Cultural Heritage

Superplastic deformation of P/M and I/M Al-Li based alloys

International Nuclear Information System (INIS)

Lederich, R.J.; Sastry, S.M.L.

1984-01-01

Incremental strain-rate and constant strain-rate cone-forming tests have been carried out at 450-550 C to investigate the superplastic forming characteristics of Al-Li-Cu-Mn, Al-Li-Cu-Mg-Zr, and Al-Li-Zn-Mg alloys processed by powder-metallurgy (P/M) and ingot-metallurgy (I/M) techniques. It is found that P/M Al-Li alloys containing 0.2 pct Zr are inherently superplastically formable without the need for extensive thermomechanical processing. I/M Al-Li alloys containing Zr are also superplastically formable. The mechanical properties of the superplastically formed and solution-treated-and-aged alloys are comparable to those of solution-treated-and-aged alloys before superplastic forming. 6 references

Adaptively loaded IM/DD optical OFDM based on set-partitioned QAM formats.

Science.gov (United States)

Zhao, Jian; Chen, Lian-Kuan

2017-04-17

We investigate the constellation design and symbol error rate (SER) of set-partitioned (SP) quadrature amplitude modulation (QAM) formats. Based on the SER analysis, we derive the adaptive bit and power loading algorithm for SP QAM based intensity-modulation direct-detection (IM/DD) orthogonal frequency division multiplexing (OFDM). We experimentally show that the proposed system significantly outperforms the conventional adaptively-loaded IM/DD OFDM and can increase the data rate from 36 Gbit/s to 42 Gbit/s in the presence of severe dispersion-induced spectral nulls after 40-km single-mode fiber. It is also shown that the adaptive algorithm greatly enhances the tolerance to fiber nonlinearity and allows for more power budget.

Malignant acanthosis nigricans: an early diagnostic clue

International Nuclear Information System (INIS)

Amjad, M.; Shah, A.A.; Bari, A.U.

2010-01-01

Acanthosis nigricans (AN) is characterized by velvety, hyper pigmented, verrucosus, symmetric and occasionally pruritic plaques along with papillomatous lesions which have a special predilection for neck, axillae, groin, umbilicu and mucosal regions. Rarely, it presents as a para neoplastic syndrome and prompts a thorough search for an internal malignancy. We present here a case of malignant acanthosis nigricans seen in an elderly patient who was found to have underlying adenocarcinoma of the lower end of esophagus. After diagnosing associated malignancy, he was referred for further evaluation and subsequent surgical resection of tumour. (author)

Immunotherapy of Genitourinary Malignancies

Directory of Open Access Journals (Sweden)

Teruo Inamoto

2012-01-01

Full Text Available Most cancer patients are treated with some combination of surgery, radiation, and chemotherapy. Despite recent advances in local therapy with curative intent, chemotherapeutic treatments for metastatic disease often remain unsatisfying due to severe side effects and incomplete long-term remission. Therefore, the evaluation of novel therapeutic options is of great interest. Conventional, along with newer treatment strategies target the immune system that suppresses genitourinary (GU malignancies. Metastatic renal cell carcinoma and non-muscle-invasive bladder caner represent the most immune-responsive types of all human cancer. This review examines the rationale and emerging evidence supporting the anticancer activity of immunotherapy, against GU malignancies.

Sexualität im Werk Arno Schmidts

OpenAIRE

Reischert, Jessica

2006-01-01

Die Sexualität im Frühwerk Arno Schmidts stellt ein umfangreiches und komplexes Thema dar, das dennoch auf gewisse Grundmuster und –vorgänge reduziert werden kann. So haben sich bei der Begegnung von Menschen untereinander klare Linien ergeben, anhand derer viele Gespräche eingeordnet und analysiert werden können. Unterschieden werden können mehrere Gesprächstypen, in denen sich bestimmte Verhaltensweisen der Schmidtschen Protagonisten zeigen: In den geschlechtlich gemischten Gesprächsrunden ...

Kriminologie und Kriminalistik im Zugriff der Geschichtswissenschaft

Directory of Open Access Journals (Sweden)

Peter-Alexis Albrecht

2007-01-01

Full Text Available Rezensierte Werke:Silviana Galassi, Kriminologie im Deutschen Kaiserreich. Geschichte einer gebrochenen Verwissen­schaftlichung, Stuttgart: Franz Steiner Verlag 2004, 452 S., ISBN 3-515-08352-9; Peter Becker, Dem Täter auf der Spur. Eine Geschichte der Kriminalistik, Darmstadt: Primus Verlag 2005, 287 S., ISBN 3-89678-275-4; Peter Becker, Richard F. Wetzell (Hg., Criminals and their Scientists. The History of Criminology in International Perspective, Cambridge: Cambridge University Press 2006, 492 S., ISBN 0-521-81012-4

Multimedia adaptation with SIP resource availability signalling in IMS-networks

NARCIS (Netherlands)

Ozcelebi, T.; Radovanovic, I.

2007-01-01

Unlicensed, nondedicated and nondeterministic computer access networks are included in IP multimedia subsystem (IMS) in addition to the operator core network, which arises new end-to-end quality-of-service (QoS) issues for multimedia streaming. The resource availability of the network and the

Hospital end-of-life care in haematological malignancies.

Science.gov (United States)

Beaussant, Yvan; Daguindau, Etienne; Chauchet, Adrien; Rochigneux, Philippe; Tournigand, Christophe; Aubry, Régis; Morin, Lucas

2018-02-06

To investigate patterns of care during the last months of life of hospitalised patients who died from different haematological malignancies. Nationwide register-based study, including all hospitalised adults ≥20 years who died from haematological malignancies in France in 2010-2013. Outcomes included use of invasive cancer treatments and referral to palliative care. Percentages are adjusted for sex and age using direct standardisation. Of 46 629 inpatients who died with haematological malignancies, 24.5% received chemotherapy during the last month before death, 48.5% received blood transfusion, 12.3% were under invasive ventilation and 18.1% died in intensive care units. We found important variations between haematological malignancies. The use of chemotherapy during the last month of life varied from 8.6% among patients with chronic myeloid leukaemia up to 30.1% among those with non-Hodgkin's lymphoma (Pcare units. A high proportion of patients who died from haematological malignancies receive specific treatments near the end of life. There is a need for a better and earlier integration of the palliative care approach in the standard practice of haematology. However, substantial variation according to the type of haematological malignancy suggests that the patients should not be considered as one homogeneous group. Implementation of palliative care should account for differences across haematological malignancies. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Otizm Spektrum Bozukluğu Olan Çocukların Sosyal İletişim Becerileri ve Dil Gelişim Özellikleri

Directory of Open Access Journals (Sweden)

Meral Çilem Ökcün-Akçamuş

2016-08-01

Full Text Available Dil ve iletişim alanında yaşanan güçlükler, otizm spektrum bozukluğunun (OSB tanı ölçütlerinden birisidir ve bu güçlükler OSB olan çocuklarda otizmin şiddetini belirleyen önemli bir değişken olarak ele alınmaktadır. OSB olan çocukların dil gelişiminde heterojen bir yapı olduğu kabul edilmektedir. OSB olan bazı çocuklar sözel dili hiç edinemezken, bazı çocuklarda normal gelişim gösteren akranlarına yakın bir sözel dil kullanım örüntüsü görülebilmektedir. Bu derleme çalışmasında OSB olan çocukların dil ve iletişim becerilerine ilişkin gelişimsel özellikleri incelenmiştir. OSB olan çocuklarda söz öncesi dönemde sözel olmayan sosyal iletişim becerilerine, sözel dil döneminde dilin bileşenlerine ilişkin sendroma özgü gelişimsel özellikler/bozukluklar görülmektedir. Bu nedenle bu derleme çalışmasında OSB olan çocukların söz öncesi dönemde sözel olmayan sosyal iletişim becerilerine yönelik gelişimleri ele alınacaktır. Bunun yanı sıra sözel dil döneminde olan OSB olan çocukların dilin biçimbirim bilgisi/sözdizimi, anlam bilgisi ve kullanım bilgisi bileşenlerine yönelik gelişimsel özellikleri incelenecektir. Alanyazından derlenen bu çalışmanın OSB olan çocuklarda dil gelişimi üzerine çalışan öğretmenlere ve araştırmacılara yol göstereceği düşünülmektedir. Difficulties in language and communication are diagnostic criteria of autism spectrum disorders (ASD and these difficulties are taken as an important variable in determining the severity of the disorder for the children with ASD. It is accepted that language development of children with ASD is heterogeneous. While some of the children can never acquire language, some of them may show language use similar to their peers with typical development. In this review developmental characteristics of children with ASD in language and communication skills are examined. Children with ASD show

Effectiveness of onsite wastewater reuse system in reducing bacterial contaminants measured with human-specific IMS/ATP and qPCR.

Science.gov (United States)

Agidi, Senyo; Vedachalam, Sridhar; Mancl, Karen; Lee, Jiyoung

2013-01-30

Water shortages and the drive to recycle is increasing interest in reuse of reclaimed wastewater. Timely and cost-effective ways to detect fecal pollutants prior to reuse increases confidence of residents and neighbors concerned about reuse of reclaimed wastewater. The on-site wastewater treatment and reuse systems (OWTRS) used in this study include a septic tank, peat bioreactor, ClO(2) disinfection and land spray irrigation system. Bacteroides fragilis, Escherichia coli and Enterococcus spp., were tested with immunomagnetic separation/ATP bioluminescence (IMS/ATP), qPCR and culture-based methods. The results displayed a 2-log reduction in fecal bacteria in the peat bioreactor and a 5-log reduction following chloride dioxide disinfection. The fecal bacteria levels measured by IMS/ATP correlated with qPCR results: HuBac 16S (R(2) = 0.903), Bf-group 16S (R(2) = 0.956), gyrB (R(2) = 0.673), and Ent 23S (R(2) = 0.724). This is the first study in which the newly developed human-specific IMS/ATP and previously developed IMS/ATP were applied for determining OWTRS efficiency. Results of the study revealed that IMS/ATP is a timely and cost-effective way to detect fecal contaminants, and results were validated with qPCR and culture based methods. The new IMS/ATP can also be applied broadly in the detection of human-originated fecal contamination. Copyright © 2012 Elsevier Ltd. All rights reserved.

SERS-based inverse molecular sentinel (iMS) nanoprobes for multiplexed detection of microRNA cancer biomarkers in biological samples

Science.gov (United States)

Crawford, Bridget M.; Wang, Hsin-Neng; Fales, Andrew M.; Bowie, Michelle L.; Seewaldt, Victoria L.; Vo-Dinh, Tuan

2017-02-01

The development of sensitive and selective biosensing techniques is of great interest for clinical diagnostics. Here, we describe the development and application of a surface enhanced Raman scattering (SERS) sensing technology, referred to as "inverse Molecular Sentinel (iMS)" nanoprobes, for the detection of nucleic acid biomarkers in biological samples. This iMS nanoprobe involves the use of plasmonic-active nanostars as the sensing platform for a homogenous assay for multiplexed detection of nucleic acid biomarkers, including DNA, RNA and microRNA (miRNA). The "OFF-to-ON" signal switch is based on a non-enzymatic strand-displacement process and the conformational change of stem-loop (hairpin) oligonucleotide probes upon target binding. Here, we demonstrate the development of iMS nanoprobes for the detection of DNA sequences as well as a modified design of the nanoprobe for the detection of short (22-nt) microRNA sequences. The application of iMS nanoprobes to detect miRNAs in real biological samples was performed with total small RNA extracted from breast cancer cell lines. The multiplex capability of the iMS technique was demonstrated using a mixture of the two differently labeled nanoprobes to detect miR-21 and miR-34a miRNA biomarkers for breast cancer. The results of this study demonstrate the feasibility of applying the iMS technique for multiplexed detection of nucleic acid biomarkers, including short miRNAs molecules.

The renin-angiotensin system in malignant hypertension revisited: plasma renin activity, microangiopathic hemolysis, and renal failure in malignant hypertension

NARCIS (Netherlands)

van den Born, Bert-Jan H.; Koopmans, Richard P.; van Montfrans, Gert A.

2007-01-01

BACKGROUND: Malignant hypertension is a renin-dependent form of hypertension. However, the variations in renin-angiotensin system (RAS) activation in malignant hypertension are not completely understood. A proposed mechanism for ongoing RAS activation is the presence of microangiopathic hemolysis

Primary malignant small bowel tumor

Energy Technology Data Exchange (ETDEWEB)

Oh, Kyung Seung; Suh, Ho Jong; Kim, So Sun; Kim, Ho Joon; Chun, Byung Hee; Joh, Young Duk [Kosin College, Pusan (Korea, Republic of)

1990-07-15

Small bowel tumors are rarely detected unless there is intestinal obstruction or bleeding. In the seven years 1982-1988, at Kosin Medical Center, 25 primary malignant small bowel tumors were studied radiographically with barium and / or computed tomography (CT). CT revealed gastrointestinal abnormalities in 20 patients. In ten, lesion were identified by upper G-I series, in 15 by small bowel series, and in addition, in 3 by colon enema. The most common malignant small bowel tumor was adenocarcinoma (N=15) and was next common lymphoma (N=7). On barium study, primary adenocarcinoma appeared as an irregular stricture (66.7%) and polypoid mass with intussusception was most prominent finding in lymphoma. Leiomyosarcoma appeared as an exophytic mass with excavation or ulceration. CT was found to be accurate in detecting wall thickening, complications and other associated findings. In conclusion, barium study was useful in the diagnosis of primary malignant small bowel tumor and CT was more accurate in detecting secondary findings.

Primary malignant small bowel tumor

International Nuclear Information System (INIS)

Oh, Kyung Seung; Suh, Ho Jong; Kim, So Sun; Kim, Ho Joon; Chun, Byung Hee; Joh, Young Duk

1990-01-01

Small bowel tumors are rarely detected unless there is intestinal obstruction or bleeding. In the seven years 1982-1988, at Kosin Medical Center, 25 primary malignant small bowel tumors were studied radiographically with barium and / or computed tomography (CT). CT revealed gastrointestinal abnormalities in 20 patients. In ten, lesion were identified by upper G-I series, in 15 by small bowel series, and in addition, in 3 by colon enema. The most common malignant small bowel tumor was adenocarcinoma (N=15) and was next common lymphoma (N=7). On barium study, primary adenocarcinoma appeared as an irregular stricture (66.7%) and polypoid mass with intussusception was most prominent finding in lymphoma. Leiomyosarcoma appeared as an exophytic mass with excavation or ulceration. CT was found to be accurate in detecting wall thickening, complications and other associated findings. In conclusion, barium study was useful in the diagnosis of primary malignant small bowel tumor and CT was more accurate in detecting secondary findings

Topologieoptimierung im Creo-Umfeld mit ProTopCI

OpenAIRE

Simmler, Urs

2016-01-01

Wikipedia umschreibt die Topologieoptimierung als ein computerbasiertes Berechnungsverfahren, durch welches eine günstige Grundgestalt (Topologie) für Bauteile unter mechanischer Belastung ermittelt werden kann. Durch die Verwendung von 3D-Druck-Verfahren wird die Gestaltung der Komponenten revolutioniert, weil diese nicht mehr abhängig vom Fertigungsverfahren sind. Dabei werden auch optimale Gitterstrukturen innerhalb der Komponenten immer wichtiger. Diese neuen Herausforderungen können im C...

Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma

International Nuclear Information System (INIS)

Kaushik, Shaifali; Smoker, Wendy R.K.; Frable, William J.

2002-01-01

A case of malignant transformation of polyostotic fibrous dysplasia into maxillary chondroblastic osteosarcoma is presented. The clinical, radiographic, CT, MR imaging features and pathological findings of polyostotic fibrous dysplasia and its malignant transformation are described. Malignant transformation of fibrous dysplasia is rare and has not previously been described in the English literature in this location in McCune-Albright syndrome and in the absence of radiation treatment. (orig.)

AN ANALYSIS OF MALIGNANCIES PRESENTING AS ACUTE GENERAL SURGICAL EMERGENCIES

Directory of Open Access Journals (Sweden)

Kannan Ross

2017-02-01

Full Text Available BACKGROUND Malignancies in the setting of acute general surgical emergencies are rare to present. The commonly presenting malignancies to the general surgeon in emergency conditions are perforation, obstruction, haemorrhage or urinary retention. Though their incidence when compared to benign conditions presenting with same clinical presentations are rare, they should never be neglected. The general surgeon must be aware of such presentations and hereby decide the management and follow up according to the malignancy he encounters on the operation theatre. The management should aim at radical procedures and regular follow up if needed with chemotherapy or radiotherapy and also should be well informed of the morbidity and mortality following intervention considering the malignancy grade, age of patient, duration of presentation and co-morbid conditions. MATERIALS AND METHODS In this study, we consider all patients taken up in emergency operative procedures, study their findings on operation theatre, correlate with their biopsy report for any malignancy and follow up during their immediate postop up to <30 days and also late post beyond the procedure and bring about the incidence, common modes of presentation, malignancies encountered, age and sex distribution and the perioperative morbidity and mortality rates of the those malignancies. RESULTS The incidence of malignancies presenting as acute abdominal emergencies in this study was found to be around 8.27%. The number of males who presented with such malignancies outnumbered females in a significant manner in the ratio 1.6:1. Among the malignancies, gastric (25% and colonic malignancies (59.38% were the most common. Perforation was the only presentation as acute emergency in carcinoma stomach. Incidence of malignancy in gastric perforation was 57.14% when compared to that reported by Emer Ergul et al that about 10-16% of all gastric perforations are caused by gastric carcinoma. 11 Perioperative

Automation of PCXMC and ImPACT for NASA Astronaut Medical Imaging Dose and Risk Tracking

Science.gov (United States)

Bahadori, Amir; Picco, Charles; Flores-McLaughlin, John; Shavers, Mark; Semones, Edward

2011-01-01

To automate astronaut organ and effective dose calculations from occupational X-ray and computed tomography (CT) examinations incorporating PCXMC and ImPACT tools and to estimate the associated lifetime cancer risk per the National Council on Radiation Protection & Measurements (NCRP) using MATLAB(R). Methods: NASA follows guidance from the NCRP on its operational radiation safety program for astronauts. NCRP Report 142 recommends that astronauts be informed of the cancer risks from reported exposures to ionizing radiation from medical imaging. MATLAB(R) code was written to retrieve exam parameters for medical imaging procedures from a NASA database, calculate associated dose and risk, and return results to the database, using the Microsoft .NET Framework. This code interfaces with the PCXMC executable and emulates the ImPACT Excel spreadsheet to calculate organ doses from X-rays and CTs, respectively, eliminating the need to utilize the PCXMC graphical user interface (except for a few special cases) and the ImPACT spreadsheet. Results: Using MATLAB(R) code to interface with PCXMC and replicate ImPACT dose calculation allowed for rapid evaluation of multiple medical imaging exams. The user inputs the exam parameter data into the database and runs the code. Based on the imaging modality and input parameters, the organ doses are calculated. Output files are created for record, and organ doses, effective dose, and cancer risks associated with each exam are written to the database. Annual and post-flight exposure reports, which are used by the flight surgeon to brief the astronaut, are generated from the database. Conclusions: Automating PCXMC and ImPACT for evaluation of NASA astronaut medical imaging radiation procedures allowed for a traceable and rapid method for tracking projected cancer risks associated with over 12,000 exposures. This code will be used to evaluate future medical radiation exposures, and can easily be modified to accommodate changes to the risk

ImTK: an open source multi-center information management toolkit

Science.gov (United States)

Alaoui, Adil; Ingeholm, Mary Lou; Padh, Shilpa; Dorobantu, Mihai; Desai, Mihir; Cleary, Kevin; Mun, Seong K.

2008-03-01

The Information Management Toolkit (ImTK) Consortium is an open source initiative to develop robust, freely available tools related to the information management needs of basic, clinical, and translational research. An open source framework and agile programming methodology can enable distributed software development while an open architecture will encourage interoperability across different environments. The ISIS Center has conceptualized a prototype data sharing network that simulates a multi-center environment based on a federated data access model. This model includes the development of software tools to enable efficient exchange, sharing, management, and analysis of multimedia medical information such as clinical information, images, and bioinformatics data from multiple data sources. The envisioned ImTK data environment will include an open architecture and data model implementation that complies with existing standards such as Digital Imaging and Communications (DICOM), Health Level 7 (HL7), and the technical framework and workflow defined by the Integrating the Healthcare Enterprise (IHE) Information Technology Infrastructure initiative, mainly the Cross Enterprise Document Sharing (XDS) specifications.