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Sample records for malaysian mahseer tor

  1. Optimum dietary protein requirement of Malaysian mahseer (Tor tambroides) fingerling.

    Misieng, Josephine Dorin; Kamarudin, Mohd Salleh; Musa, Mazlinda

    2011-02-01

    The optimum dietary protein requirement of the Malaysian mahseer (Tor tambroides) fingerlings was determined in this study. In this completely randomized designed experiment, formulated diets of five levels of dietary protein (30, 35, 40, 45 and 50%) were tested on the T. tambroides fingerlings (initial body weight of 5.85 +/- 0.40 g), reared in aquarium fitted with a biofiltering system. The fingerlings were fed twice daily at 5% of biomass. The fingerling body weight and total length was taken at every two weeks. Mortality was recorded daily. The dietary protein had significant effects on the body weight gain and Specific Growth Rate (SGR) of the fingerlings. The body weight gain and SGR of fingerlings fed with the diet with the dietary protein level of 40% was significantly higher (p<0.05) than that of 30, 35 and 50%. The feed conversion ratio of the 40% dietary protein was the significantly lowest at 2.19 +/- 0.163. The dietary protein level of 40% was the most optimum for T. tambroides fingerlings.

  2. Effects of varying dietary carbohydrate levels on growth performance, body composition and liver histology of Malaysian mahseer fingerlings (Tor tambroides).

    Ishak, Sairatul Dahlianis; Kamarudin, Mohd Salleh; Ramezani-Fard, Ehsan; Saad, Che Roos; Yusof, Yus Aniza

    2016-07-01

    We investigated the effects of four iso-nitrogenous (40% crude protein) and iso-caloric (17.6 kJ g(-1)) diets with different dietary carbohydrate levels (15%, 20%, 25% and 30%) on the growth performance, feed utilization efficiency, body composition and liver histology of Malaysian mahseer (Tor tambroides) fingerlings in a 10-week feeding trial. Fish (initial weight of 0.8?0.1 g; initial total length 4.2?0.1 cm) were fed twice daily at 4% body mass. Dietary carbohydrate level had significant effects (P<0.05) on weight gain, SGR (specific growth rate), FCR (feed conversion rate), PER (protein efficiency rate), survival percentage and all nutrient retention values (PRV, LRV, CRV, ERV). Protein, carbohydrate and gross energy composition of the fish body were also significantly differed (P<0.05) among treatments. Liver histology showed mild hepatic steatosis and hypertrophy for fishes receiving a higher dietary carbohydrate inclusion. In general, treatments with 20% and 25% dietary carbohydrate levels produced better growth results compared to the rest of the treatments. Using a second-order polynomial regression analysis model, the optimal dietary carbohydrate level of 23.4% was estimated for mahseer fingerlings. ?

  3. Domestication of Mahseer (Tor soro) in Indonesia.

    Gustiano, R; Kontara, E K; Wahyuningsih, H; Subagja, J; Asih, S; Saputr, A

    2013-01-01

    Mahseer is an economically important fish in the world with a distribution from the Himalayan Mountains up to Southeast Asia. One species of Masheer is Tor soro in the Indonesian Archipelago. For a long time, T. soro has been collected from the wild and now is becoming rare. In addition, the degradation of its habitat is another problem. Hence, it is urgent that this species is saved from extinction. Domestication of T. soro from North Sumatra has been conducted since 1996. This paper reports the results of domestication of T. soro starting from collecting live specimens, genetic and morphometric characterizations, evaluation to breeding, and growing out. In 2010, domestication was successful to produce a second generation of young broodstocks and now the breeding technology is being shared with several provinces where T. soro exist.

  4. Host gut-derived probiotic bacteria promote hypertrophic muscle progression and upregulate growth-related gene expression of slow-growing Malaysian Mahseer Tor tambroides

    Md Asaduzzaman

    2018-02-01

    Full Text Available In modern aquaculture, dietary supplementation of probiotics is a novel approach for enhancing growth performance of slow-growing fish. However, the actual role of probiotics in regulating muscle growth at cellular and molecular levels in fish still needs to be clarified. In this study, we hypothesized that host gut derived probiotic bacteria would enhance cellular muscle growth, and upregulate growth-related gene expression in slow-growing Malaysian mahseer Tor tambroides. Therefore, three host-associated probiotics (Bacillus sp. AHG22, Alcaligenes sp. AFG22, and Shewanella sp. AFG21 were isolated from the gastro-intestinal tract of T. tambroides and screened based on their digestive enzyme activity. A fishmeal and casein based control diet (40% crude protein and 10% lipid was formulated, and three different probiotic supplemented diets were prepared by immersing the control diet in each isolated host-derived bacteria, suspended in sterile phosphate buffered saline (PBS, to achieve a final concentration of approximately 1.0 × 108 CFU g−1 feed. Triplicate groups of T. tambroides juveniles (initial weight 1.39 ± 0.06 g were stocked in twelve glass aquaria (100 L capacity with stocking density of 20 individuals per aquarium. The feed was applied twice daily at 3.0% of the fish body weight per day for 90 days. Growth performance (weight gain and specific growth rate of T. tambroides juveniles were significantly higher in Alcaligenes sp. AFG22 and Bacillus sp. AHG22 supplemented diet treatments. Muscle morphometric analysis revealed that dietary supplementation of host-associated probiotic bacteria did not influence the frequency distribution of hyperplastic (class 10 small diameter fibers (≤10 μm. However, hypertrophic (Class 50, Class 60 and Class 70 large diameter fibers (>50 μm were significantly higher in Alcaligenes sp. AFG22 and Bacillus sp. AHG22 supplemented treatments, indicating that increased growth rate of T

  5. External morphometric study of hatchery reared mahseer ( Tor ...

    Different samples of Mahseer (Tor putitora) were examined for the study of external morphometric characters of the fish. Slopes of log transformed data were used for comparison with an isometric slopes (b=1, b= 0.33 or b= 3). Relationships between wet body weight and external body parts lengths showed that increasing ...

  6. Mahseers genera Tor and Neolissochilus (Teleostei: Cyprinidae) from southern Vietnam.

    Hoàng, Huy Đức; Phạm, Hùng Mạnh; Durand, Jean-Dominique; Trần, Ngân Trọng; Phan, Phúc Đình

    2015-08-25

    Two new species and two new basin records of mahseers in the genera Tor and Neolissochilus are described from the upper Krong No and middle Đồng Nai drainages of the Langbiang Plateau in southern Vietnam. These new species and new records are known from streams and rivers in montane mixed pine and evergreen forests between 140 and 1112 m. Their populations are isolated in the Sre Pok River of the Mekong basin, the middle of the Đồng Nai basin, and the An Lão River. Both new species are differentiated from their congeners by a combination of the following characters: 23-24 lateral scales, 9-10 predorsal scales, 2/7 or 1/8 pelvic-fin rays, mouth position, median lobe of lower lip, rostral hood, colour in life and by divergent mitochondrial DNA. Tor mekongensis sp. nov. is differentiated from Tor dongnaiensis sp. nov. by the number of transverse scale rows (3/1/2 vs. 4/1/2), number of pelvic-fin rays (2/7 vs. 1/8), a blunt rostral hood vs. pointed, caudal-fin lobes that are equal vs. unequal, and by mitochondrial DNA (0.7% sequence divergence). Molecular evidence identifies both species as members of the genus Tor and distinct from all congeners sampled (uncorrected sequence divergences >1.9% for all Tor species for which homologous COI sequences are available). Tor sinensis is recorded in the Krong No and the Sre Pok rivers, further south of its known distribution. Polymorphism is described in Neolissochilus stracheyi with a Tor-like morph and a Neolissochilus-like morph.

  7. Cellular muscle growth and molecular cloning and expression of growth-related gene of Malaysian Mahseer Tor tambroides larvae fed with live and formulated feeds in indoor nursery rearing system

    Md. Asaduzzaman

    2017-02-01

    Full Text Available The influences of live and formulated feeds on growth performances, muscle fibers morphometry and muscle growth-related gene expression of Malaysian mahseer, Tor tambroides larvae were evaluated in indoor nursery rearing system. Quadruplicate groups of T. tambroides larvae (0.07 ± 0.01 g, mean ± SE were stocked in sixteen aquaria (60 × 30 × 30 cm, randomly arranged in four dietary treatments viz. larvae fed artemia (LA, moina (LM, daphnia (LD and formulated feed (FF with stocking density of 34 larvae per aquarium. The larvae were fed to visually near satiation in two equal feedings per day, seven days per week for 75 days. The growth-related parameters (mean weight gain and specific growth rate were significantly highest in treatment FF, followed by treatment LA and the lowest in treatment LD or LM. Histological observation and muscle morphometric analysis revealed that mosaic hyperplasia was observed after 50 days of the feeding trial. Hypertrophic (diameter class 50 = 40 > d ≤ 50 μm and class 60 = d > 50 μm, but not hyperplastic (diameter class ≤10 μm, muscle fibers frequencies were significantly highest in larvae fed FF compared to those fed live feeds. The entire open reading frame cDNA sequences of two important growth-related genes, myogenin and MyoD, were successfully amplified and cloned from T. tambroides larvae. The nucleotide sequences alignment using CLUSTAL W in BioEdit program of both MyoD and myogenin genes showed the sign of existence of isoforms and highly conserved with other cyprinid fishes. Real-time PCR data demonstrated that myogenin and MyoD gene expressions were significantly upregulated in larvae fed FF. The results of the present experiment concluded that the nursery rearing of T. tambroides larvae with formulated feed showed augmented muscle growth and upregulated growth-related gene expression than feeding live feeds.

  8. Complete mitochondrial genome of threatened mahseer Tor tor ...

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    In the present study, complete mitochondrial genome of Tor tor has been sequenced .... Most of the genes were encoded on the heavy strand (H- strand), whereas only .... 4 bp in the DHU stem (figure 5 in electronic supplementary material).

  9. Complete mitochondrial genome of threatened mahseer Tor tor ...

    In the present study, complete mitochondrial genome of Tor tor has been ... ative mitogenome analysis shows higher divergence value at ND1 gene than COI gene. Further .... of these genes was 11,408 bp, accounting for 68.8% of the.

  10. Effects of host gut-derived probiotic bacteria on gut morphology, microbiota composition and volatile short chain fatty acids production of Malaysian Mahseer Tor tambroides

    Md. Asaduzzaman

    2018-02-01

    Full Text Available Three host-associated probiotics (Bacillus sp. AHG22, Alcaligenes sp. AFG22, and Shewanella sp. AFG21 were isolated from the gastrointestinal tract of Tor tambroides, and their effects were evaluated on gut morphology, microbiota composition and volatile short chain fatty acids (VSCFAs production of the same species. A control diet (40% crude protein and 10% lipid was formulated, and three different probiotic supplemented diets were prepared by immersing the control diet in each host-derived isolated probiotic, suspended in sterile phosphate buffered saline (PBS, to achieve concentration at 1.0 × 108 CFU g−1 feed. Triplicate groups of T. tambroides juveniles (1.39 ± 0.06 g were stocked in twelve glass aquaria (100 L capacity with stocking density of 20 individuals per aquarium. The feed was applied twice daily at 3.0% of the body weight per day for 90 days. The intake of probiotics drastically modified the gut microbiota composition. The average number of OTUs, Shannon index and Margalef species richness were significantly higher in host-associated probiotic treatments compared to the control. A significant increase of lipolytic, proteolytic and cellulolytic bacterial number were observed in the gastrointestinal tracts of T. tambroides fed the diets supplemented with Alcaligenes sp. AFG22 compared to the control. Villus length, villus width and villus area were significantly higher in T. tambroides juveniles fed the diet supplemented with Alcaligenes sp. AFG22. Acetate and butyrate were detected as main VSCFA production in the gastrointestinal tract of T. tambroides. Acetate and total VSCFAs production in Alcaligenes sp. AFG22 supplemented treatment was significantly higher than control. These results indicate that host-derived probiotics, especially Alcaligenes sp. has a significant potential as an important probiotic to enhance the nutrients utilization and metabolism through increasing gut surface area and VSCFAs

  11. Complete mitochondrial genome of threatened mahseer Tor tor (Hamilton 1822) and its phylogenetic relationship within Cyprinidae family.

    Pavan-Kumar, A; Raman, Sudhanshu; Koringa, Prakash G; Patel, Namrata; Shah, Tejas; Singh, Rajeev K; Krishna, Gopal; Joshi, C G; Gireesh-Babu, P; Chaudhari, Aparna

    2016-12-01

    The mahseers (Tor, Neolissochilus and Naziritor) are an important group of fishes endemic to Asia with the conservation status of most species evaluated as threatened. Conservation plans to revive these declining wild populations are hindered by unstable taxonomy. Molecular phylogeny studies with mitochondrial genome have been successfully used to reconstruct the phylogenetic tree and to resolve taxonomic ambiguity. In the present study, complete mitochondrial genome of Tor tor has been sequenced using ion torrent next-generation sequencing platform with coverage of more than 1000 x. Comparative mitogenome analysis shows higher divergence value at ND1 gene than COI gene. Further, occurrence of a distinct genetic lineage of T. tor is revealed. The phylogenetic relationship among mahseer group has been defined as Neolissochilus hexagonolepis ((T. sinensis (T. putitora, T. tor), (T. khudree, T. tambroides)).

  12. REPRODUCTIVE CHARACTERISTICS OF INDONESIA MAHSEER (Tor tambroides, Bleeker, 1854, IN TWO DIFFERENT RIVERS IN WESTERN SUMATERA

    Arif Wibowo

    2014-12-01

    Full Text Available The reproductive characteristics of mahseer, Tor. tambroides, were studied in Manna River and Batang Tarusan River, which are located on each side of Western Sumatera River. The reproductive period of T. tambroides is largely consistent with that described for the species in other areas, however monthly variations in the extent and timing of peak spawning are recorded. The analysis of the sex ratio indicates an increase in the percentage of females with size, more marked in largest sizes. Seasonal patterns in the occurrences of spawning showed that the spawning season in Manna River lasted was similar with that in Batang Tarusan River, although a second prominent increase of GSI was observed in April and September in Manna River, meanwhile the GSI of Batang Tarusan River fish were below 2 without an apparent variation. L50s of Manna River and Batang Tarusan River mahseer were estimated as 24.5 cm and 20.66 cm, respectively, indicating a high variability in size at first maturity of the mahseer population. Our study provides some important information on the reproductive biology of T. tambroides that will be helpful in similar studies and contributed to fisheries management of this species.

  13. Effects of canarium fruit (Canarium odontophyllum oil as a dietary lipid source for juvenile mahseer (Tor tambroides performance

    M.L. Bami

    2017-05-01

    Full Text Available Canarium is among the riverine fruits that are commonly found in the natural diet of Malaysian mahseer, Tor tambroides. The fruit contains a high percentage of lipids. This study was conducted to investigate the effects of canarium crude oil on the growth performance, body composition and fatty acid profile of juvenile T. tambroides. Five isonitrogenous (40% crude protein diets containing varying canarium oil levels (0, 1.25, 2.5, 3.75 and 5% were prepared. Crude palm oil (CPO was used as the control. The juveniles (2.08 ± 0.10 g were given the test diets for 12 weeks in triplicate groups. Diets containing canarium oil were found to be less accepted by the fish which led to a significantly lower (P  0.05 on survival and lean portion of juvenile T. tambroides. The fish fed canarium oil-free diet also had better tissue fatty acid profile (especially n-3 and n-6 PUFA as well as better protein, lipid and energy retention than those fed diets including canarium oil. From the results, canarium oil extracted from the whole fruit was not recommended as a dietary lipid source for T. tambroides. Moreover, juveniles fed on 0% canarium oil (5% CPO utilized dietary saturated fatty acids (SFA and monounsaturated fatty acids (MUFA more efficiently for their energy requirement than fish given canarium oil.

  14. Synergistic effects of dietary nano selenium and vitamin C on growth, feeding, and physiological parameters of mahseer fish (Tor putitora

    Kifayat Ullah Khan

    2017-02-01

    Full Text Available The current study was conducted to determine the synergistic effects of dietary nano selenium (Nano Se and vitamin C on growth, feeding, and physiological parameters of juvenile mahseer, Tor putitora. L-ascorbyl-2-polyphosphate (APP was used as a source of vitamin C. Four semi-purified experimental diets were prepared. A basal diet kept without the supplementation of any micronutrient and the other three diets were formulated such that three different levels of APP (100, 200, and 300 mg kg−1 were used in combination with a pre-determined dose of Nano Se (0.68 mg kg−1. The results showed that both the micronutrients positively synergized the effects of each other. APP at the rate of 300 mg kg−1 showed strong interaction with Nano Se. The APP300 + Nano Se0.68 mg kg−1 diet supplemented diet significantly decreased (P< 0.05 the feed conversion ratio (FCR while significantly increased (P< 0.05 the weight gain percentage (WG%, feed conversion efficiency (FCE%, specific growth rate (SGR, and serum growth hormone (GH concentration. Similarly, the physiological parameters such as red blood cells count (RBCs, hemoglobin level (Hb, hematocrit value (Hct, and serum lysozyme activity were also significantly increased in group of fish fed diet supplemented with APP100 mg kg−1 in combination with Nano Se0.68 mg kg−1 as compared to the control group. The present results clearly indicated the beneficent synergistic effects of Nano Se and APP in mahseer fish. Moreover, the current finding also supported our hypothesis that Nano Se and APP potentiate positively the effect of each other when both the micronutrients are supplemented together in the same fish feed.

  15. Changes over time in muscle fatty acid composition of Malaysian ...

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    2011-12-12

    Dec 12, 2011 ... Key words: Fatty acid, lipid, muscle, Malaysian mahseer, Tor tambroides. INTRODUCTION. The content of long chain n-3 polyunsaturated fatty acids. (n-3 PUFAs) differentiates fish from the other food products. These fatty acids are important beneficial nutrients for the prevention of human coronary disease,.

  16. Population structure of Tor tor inferred from mitochondrial gene cytochrome b.

    Pasi, Komal Shyamakant; Lakra, W S; Bhatt, J P; Goswami, M; Malakar, A Kr

    2013-06-01

    Tor tor, commonly called as Tor mahseer, is a high-valued food and game fish endemic to trans-Himalayan region. Mitochondrial cytochrome b (cyt b) gene region of 967 bp was used to estimate the population structure of T. tor. Three populations of T. tor were collected from Narmada (Hosangabad), Ken (Madla), and Parbati river (Sheopur) in Madhya Pradesh, India. The sequence analysis revealed that the nucleotide diversity (π) was low, ranging from 0.000 to 0.0150. Haplotype diversity (h) ranged from 0.000 to 1.000. The analysis of molecular variance analysis indicated significant genetic divergence among the three populations of T. tor. Neighboring-joining tree also showed that all individuals from three populations clustered into three distinct clades. The data generated by cyt b marker revealed interesting insight about population structure of T. tor, which would serve as baseline data for conservation and management of mahseer fishery.

  17. Testing Torness

    Roche, P.

    1987-01-01

    Fueling of the Torness-1 reactor began in July, 1987, about a year behind schedule. The main reason for the delay was the discovery of a design weakness in the control rods. This has now been put right. The Industrial Pollution Inspectorate has authorized the discharge of small quantities of liquid and gaseous radioactive waste. The need to grant this so long before the station is ready to make discharges is questioned. The actual level of discharge allowed is also a focus of criticism. The political consequences of the Torness debate is seen as the loss of seats by the Conservative party in Scotland in the General Election. More problems are foreseen for Torness over discharges and evacuation plans. (UK)

  18. Torness. Keep it green

    Flood, M.

    1979-01-01

    The subject is discussed under the following headings: Torness foolishness (concerning the steps being taken towards constructing a nuclear power station at Torness Point in East Lothian, Scotland); the case against Torness (a summary); is Torness necessary (discusses the present, planned and forecast positions of electricity supply and demand in Scotland); how much will Torness cost, and who will pay; the local impact of Torness (on employment, infrastructure, amenity and future prospects); how reliable is the Advanced Gas Cooled Reactor (the choice of the AGR type reactor and discussions on the 'Hinkley Point incident' and the 'Hunterston incident'); how safe is nuclear power (discussion on AGR programme, nuclear accidents, sabotage, war, nuclear waste, plutonium, secrecy and security); public opposition to Torness; what can be done. (U.K.)

  19. Higher acclimation temperature modulates the composition of muscle fatty acid of Tor putitora juveniles

    M.S. Akhtar

    2014-08-01

    Full Text Available A 30-day acclimation trial was conducted using golden mahseer, Tor putitora juveniles to study its muscle fatty acid composition at five acclimation temperatures (AT. Ninety juveniles of T. putitora were distributed among five treatment groups (20, 23, 26, 29 and 32±0.5 °C. At the end of 30 days trial, highest percentage of monounsaturated fatty acids was found at 20 °C and lowest at 26 °C. The highest percentage of n-6 polyunsaturated fatty acid (PUFA was found at 23 °C and a decreasing trend was observed with increase in AT. However, highest percentage of n-3 PUFA was found at 32 °C and lowest at 29 °C. The maximum n-6 to n-3 ratio was observed at 23 °C and ratio decreased to a minimum at 32 °C. The results revealed that T. putitora juveniles could adapt to higher acclimation temperatures by altering its muscle fatty acid composition mainly by increasing its total saturated fatty acids especially stearic acid.

  20. Tor-Tor Sebagai Properti Dan Perwujudan Adat

    Frida Deliana Harahap

    2009-01-01

    Tulisan ini mendeskripsikan tor?tor Angkola. Tor?tor adalah tarian adat  yang dipergunakan dalam upacara adat nagodang (adat besar), sehingga pertunjukan tor?tor  dalam upacara adat haruslah bersumber dari adat Angkola itu sendiri.  Ada dua aspek yang akan dibicarakan dalam tulisan ini:  yang pertama mengenai aspek koreografi yang juga meliputi olah gerak tubuh;  kedua, aspek tata busana penari saat melakukan pertunjukan tor?tor.   etn-sep2005-6...

  1. TOR signalling in plants.

    Rexin, Daniel; Meyer, Christian; Robaglia, Christophe; Veit, Bruce

    2015-08-15

    Although the eukaryotic TOR (target of rapamycin) kinase signalling pathway has emerged as a key player for integrating nutrient-, energy- and stress-related cues with growth and metabolic outputs, relatively little is known of how this ancient regulatory mechanism has been adapted in higher plants. Drawing comparisons with the substantial knowledge base around TOR kinase signalling in fungal and animal systems, functional aspects of this pathway in plants are reviewed. Both conserved and divergent elements are discussed in relation to unique aspects associated with an autotrophic mode of nutrition and adaptive strategies for multicellular development exhibited by plants. © 2015 Authors; published by Portland Press Limited.

  2. Evolution of the TOR Pathway.

    Dam, T.J.P. van; Zwartkruis, F.J.; Bos, J.L.; Snel, B.

    2011-01-01

    The TOR kinase is a major regulator of growth in eukaryotes. Many components of the TOR pathway are implicated in cancer and metabolic diseases in humans. Analysis of the evolution of TOR and its pathway may provide fundamental insight into the evolution of growth regulation in eukaryotes and

  3. An unsuspected autoregulatory pathway involving apocytochrome TorC and sensor TorS in Escherichia coli

    Gon, Stéphanie; Jourlin-Castelli, Cécile; Théraulaz, Laurence; Méjean, Vincent

    2001-01-01

    Trimethylamine N-oxide (TMAO) respiration is carried out mainly by the Tor system in Escherichia coli. This system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. Expression of the tor operon is positively controlled by the TorS/TorR phosphorelay system in response to TMAO availability and negatively regulated by apocytochrome TorC. Interaction studies showed tha...

  4. Torness: proposed nuclear power station

    Anon.

    1979-01-01

    The need for and desirability of nuclear power, and in particular the proposed nuclear power station at Torness in Scotland, are questioned. Questions are asked, and answered, on the following topics: position, appearance and cost of the proposed Torness plant, and whether necessary; present availability of electricity, and forecast of future needs, in Scotland; energy conservation and alternative energy sources; radiation hazards from nuclear power stations (outside, inside, and in case of an accident); transport of spent fuel from Torness to Windscale; radioactive waste management; possibility of terrorists making a bomb with radioactive fuel from a nuclear power station; cost of electricity from nuclear power; how to stop Torness. (U.K.)

  5. Development and characterization of cell culture systems from Puntius (Tor) chelynoides (McClelland).

    Goswami, M; Sharma, B S; Tripathi, A K; Yadav, Kamalendra; Bahuguna, S N; Nagpure, N S; Lakra, W S; Jena, J K

    2012-05-25

    Puntius (Tor) chelynoides, commonly known as dark mahseer, is a commercially important coldwater fish species which inhabits fast-flowing hill-streams of India and Nepal. Cell culture systems were developed from eye, fin, heart and swim bladder tissues of P. chelynoides using explant method. The cell culture system developed from eye has been maintained towards a continuous cell line designated as PCE. The cells were grown in 25cm(2) tissue culture flasks with Leibovitz' L-15 media supplemented with 20 % fetal bovine serum (FBS) at 24°C. The PCE cell line consists of predominantly fibroblast-like cells and showed high plating efficiency. The monolayer formed from the fin and heart explants were comprised of epithelial as well as fibroblast-like cells, a prominent and rhythmic heartbeat was also observed in heart explants. Monolayer formed from swim bladder explants showed the morphology of fibroblast-like cells. All the cells from different tissues are able to grow at an optimum temperature of 24°C and growth rate increased as the FBS concentration increased. The PCE cell line was characterized using amplification of mitochondrial cytochrome oxidase subunit I (COI) & 16S rRNA genes which confirmed that the cell line originated from P. chelynoides. Cytogenetic analysis of PCE cell line and cells from fin revealed a diploid count of 100 chromosomes. Upon transfection with pEGFP-C1 plasmid, bright fluorescent signals were observed, suggesting that this cell line can be used for transgenic and genetic manipulation studies. Further, genotoxicity assessment of PCE cells illustrated the utility of this cell line as an in vitro model for aquatic toxicological studies. The PCE cell line was successfully cryopreserved and revived at different passage levels. The cell line and culture systems are being maintained to develop continuous cell lines for further studies. Copyright © 2012 Elsevier B.V. All rights reserved.

  6. Malaysian NDT standards

    Khazali Mohd Zin

    2001-01-01

    In order to become a developed country, Malaysia needs to develop her own national standards. It has been projected that by the year 2020, Malaysia requires about 8,000 standards (Department of Standard Malaysia). Currently more than 2,000 Malaysian Standards have been gazette by the government which considerably too low before tire year 2020. NDT standards have been identified by the standard working group as one of the areas to promote our national standards. In this paper the author describes the steps taken to establish the Malaysian very own NDT standards. The project starts with the establishment of radiographic standards. (Author)

  7. The TorR High-Affinity Binding Site Plays a Key Role in Both torR Autoregulation and torCAD Operon Expression in Escherichia coli

    Ansaldi, Mireille; Simon, Gwénola; Lepelletier, Michèle; Méjean, Vincent

    2000-01-01

    In the presence of trimethylamine N-oxide (TMAO), the TorS-TorR two-component regulatory system induces the torCAD operon, which encodes the TMAO respiratory system of Escherichia coli. The sensor protein TorS detects TMAO and transphosphorylates the response regulator TorR which, in turn, activates transcription of torCAD. The torR gene and the torCAD operon are divergently transcribed, and the short torR-torC intergenic region contains four direct repeats (the tor boxes) which proved to be ...

  8. Malaysian Cinema, Asian Film

    Heide, van der William

    2002-01-01

    This title series departs from traditional studies of national cinema by accentuating the intercultural and intertextual links between Malaysian films and Asian (as well as European and American) film practices. Using cross-cultural analysis, the author characterizes Malaysia as a pluralist society

  9. Transportable gamma backscattering TOR-3 gauge

    Lakhmanov, P.G.; Skoblo, Yu.A.; Timofeev, V.B.

    1976-01-01

    A portable reflection gamma thickness meter TOR-3 is described having a greater measurement accuracy and wider operation temperature interval as compared to earlier serial instrument TOR-1. Integrated circuits are used in the TOR-3 construction. The principal electric diagram and technical characteristics of TOR-3 are presented

  10. Towards Predicting Efficient and Anonymous Tor Circuits

    Barton, Armon; Imani, Mohsen; Ming, Jiang; Wright, Matthew

    2018-01-01

    The Tor anonymity system provides online privacy for millions of users, but it is slower than typical web browsing. To improve Tor performance, we propose PredicTor, a path selection technique that uses a Random Forest classifier trained on recent measurements of Tor to predict the performance of a proposed path. If the path is predicted to be fast, then the client builds a circuit using those relays. We implemented PredicTor in the Tor source code and show through live Tor experiments and Sh...

  11. The Malaysian experience

    Aldon, E.T.

    1997-01-01

    Integrated farming has long been practiced in Malaysia, not only to provide protein requirements needed by the family, but also as a source of income. With fish being promoted on a larger scale, the Malaysian government is providing farmers with financial assistance and hands-on training on fish culture and rice production. Systems of fodder-fish integrated farming and fish-livestock farming in mine ponds are outlined.

  12. Malaysian mental health law.

    Khan, Nusrat N; Yahya, Badi'ah; Abu Bakar, Abd Kadir; Ho, Roger C

    2015-05-01

    The Malaysian Mental Health Act 2001 did not come into effect until the Mental Health Regulations 2010 came into force. The Act provides a framework for the delivery of comprehensive care, treatment, control, protection and rehabilitation of those with mental disorders. The Act governs the establishment of private and government psychiatric hospitals, psychiatric nursing homes and community mental health centres. This paper outlines the provisions of the Act and the Regulations.

  13. Enhancing Malaysian Teachers' Assessment Literacy

    Lian, Lim Hooi; Yew, Wun Thiam; Meng, Chew Cheng

    2014-01-01

    Currently, in order to reform the Malaysian education system, there have been a number of education policy initiatives launched by the Malaysian Ministry of Education (MOE). All these initiatives have encouraged and inculcated teaching and learning for creativity, critical, innovative and higher-order thinking skills rather than conceptual…

  14. TOR1 and TOR2 Have Distinct Locations in Live Cells▿ †

    Sturgill, Thomas W.; Cohen, Adiel; Diefenbacher, Melanie; Trautwein, Mark; Martin, Dietmar E.; Hall, Michael N.

    2008-01-01

    TOR is a structurally and functionally conserved Ser/Thr kinase found in two multiprotein complexes that regulate many cellular processes to control cell growth. Although extensively studied, the localization of TOR is still ambiguous, possibly because endogenous TOR in live cells has not been examined. Here, we examined the localization of green fluorescent protein (GFP) tagged, endogenous TOR1 and TOR2 in live S. cerevisiae cells. A DNA cassette encoding three copies of green fluorescent pr...

  15. Inhibitors of mTOR

    Klümpen, Heinz-Josef; Beijnen, Jos H.; Gurney, Howard; Schellens, Jan H. M.

    2010-01-01

    Inhibitors of mammalian target of rapamycin (mTOR) have been approved for the treatment of renal cell carcinoma and appear to have a role in the treatment of other malignancies. The primary objective of this drug review is to provide pharmacokinetic and dynamic properties of the commonly used drugs

  16. Tight tabs kept on Torness

    Ferguson, H.

    1984-01-01

    An account is given of the progress of civil engineering construction at the Torness nuclear power plant. Special reference is made to the organization of quality assurance records, through inspection and quality control at all stages of the construction, as a requirement for the licence for the plant. (U.K.)

  17. TOR Signaling and Nutrient Sensing.

    Dobrenel, Thomas; Caldana, Camila; Hanson, Johannes; Robaglia, Christophe; Vincentz, Michel; Veit, Bruce; Meyer, Christian

    2016-04-29

    All living organisms rely on nutrients to sustain cell metabolism and energy production, which in turn need to be adjusted based on available resources. The evolutionarily conserved target of rapamycin (TOR) protein kinase is a central regulatory hub that connects environmental information about the quantity and quality of nutrients to developmental and metabolic processes in order to maintain cellular homeostasis. TOR is activated by both nitrogen and carbon metabolites and promotes energy-consuming processes such as cell division, mRNA translation, and anabolism in times of abundance while repressing nutrient remobilization through autophagy. In animals and yeasts, TOR acts antagonistically to the starvation-induced AMP-activated kinase (AMPK)/sucrose nonfermenting 1 (Snf1) kinase, called Snf1-related kinase 1 (SnRK1) in plants. This review summarizes the immense knowledge on the relationship between TOR signaling and nutrients in nonphotosynthetic organisms and presents recent findings in plants that illuminate the crucial role of this pathway in conveying nutrient-derived signals and regulating many aspects of metabolism and growth.

  18. SPORTS WATCHING CULTURE AMONG MALAYSIANS

    Gunathevan Elumalai; Mohd Salleh Aman; Cassendra Gilbert; Muhammad Mat Yusof; Ahmad Tajuddin Othman; Lim Khong Chiu; Mohd Sofian Omar Fauzee; Hamdan Mohd Ali

    2015-01-01

    Background: Ardent sports watching will lead an individual to engage in sports and recreational activities continuously, while it also creates a sports culture among Malaysians. Sports watching culture is actually an intellectual activity. It is capable of evaluating behaviour, moral values and the level of appreciation of every spectator. Methods: This survey was conducted to identify the sports viewing culture among Malaysians. A cluster sampling method was used to select 6000 respondent...

  19. Torness - why it should be stopped

    1980-12-01

    The subject is discussed under the following headings: South of Scotland Electricity Board's plans; Torness (proposed nuclear power plant) and Craigroyston (proposed pumped storage scheme); no need for it; overcapacity; premature closures (of other SSEB plants); unemployment; not 'local' (reference to workers at Torness); safety unknown; secrecy; halt called for (on safety grounds); mad economics; increasing construction costs; nuclear is not cheaper; a robust economic case (query); AGR problems; Hinkley point incident; Hunterston incident; refuelling; Torness AGR.

  20. Malaysian perceptions of China

    Ibrahim Abu Bakar

    2009-11-01

    Full Text Available Malasia que consistía en Malaya, Sabah, Sarawak y Singapur ganó su independencia de los Británicos el 16 de septiembre de 1963. Malaya ganó su independencia de los británicos el 31 de agosto de 1957. En 1965 Singapur era independiente de Malasia. Malasia es una democracia parlamentaria y capitalista. Por otra parte, es una nación multi-religiosa y multirracial. Malasia ha sido poblada por los Malays, los Chinos, los Indios y otros. Los Malays son musulmanes y el Islam es la religión de la federación de Malasia. La nación tiene una larga historia con China pero esa nunca colonizó ningún área en Malasia. Los estados occidentales, fundamentalmente Portugueses y Olandeses colonizaron ciertas áreas en Malasia y luego los Británicos colonizaron la entera región. La percepción malasiana de China está influenciada por muchos factores internos y externos tales como el factor ideologico-político, el desarrollo económico así como las relaciones y la diplomacia nacionales, regionales e internacionales. Este breve artículo presenta la percepción malasiana de China desde un punto de vista cultural, político y económico._____________ABSTRACT:Malaysia consisting of Malaya, Sabah, Sarawak and Singapore gained her independence from the British on 16 September 1963. Malaya gained her independence from the British on 31 August 1957. In 1965 Singapore was independent from Malaysia. Malaysia is a parliamentary democratic and capitalistic nation. Moreover, Malaysia is a multi-religious and multiracial nation. Malaysia has been populated by the Malays, Chinese, Indians and others. The Malays are Muslims and Islam is the religion of the Federation of Malaysia. Malaysia has a very long history with China but China never colonized any area in Malaysia. The Western nations namely the Portuguese and the Dutch colonized certain areas in Malaysia and then the British colonized the whole Malaysia. Malaysian perceptions of China are influenced by many

  1. NOTES ON MALAYSIAN CYPERACEAE

    J. H. KERN

    2015-11-01

    Full Text Available This is the first paper of a series, in which preparatory to a moreomprehensive treatment for "Flora Malesiana," some noteworthy Malayian Cyperaceae will be dealt with. It is based on the material of this family in the Herbaria at Bogor (BO, Leiden (L, and Singapore (S. My sincere thanks are extended to the Directors of these institutions for giving me the opportunity to study their rich collections. In 1935—36 Kiikenthal's excellent monograph on the genus Cyperusn Engler's "Pflanzenreich" appeared. Unfortunately that author revised only a few specimens of the herbaria already mentioned, so that the basis or the distribution of the genus in Malaysia, as given in his invaluable work, compares unfavourably with that of the species of other regions. Kiikenthal's delimitation of the genus is readily accepted; in general his arrangement of the species is also followed, although I cannot agree with Kiikenthal's assertion that his system should be in close accordance withhe genetic development of the genus.On the whole only the synonymy important for the Malaysian regions given below. For a more complete account the reader is referred to Kiikenthal's monograph, in which of course the literature of merely regional interest could not always be fully considered. The accompanying plates are part of a series, drawn under my supervision by two of the draughtsmen of Herbarium Bogoriense, Sukirnoand Md. Anwar.

  2. Enhancing mTOR-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation

    Wang, Xuerong; Yue, Ping; Kim, Young Ae; Fu, Haian; Khuri, Fadlo R.; Sun, Shi-Yong

    2008-01-01

    It has been shown that mTOR inhibitors activate Akt while inhibiting mTOR signaling. However, the underlying mechanisms and the impact of the Akt activation on mTOR-targeted cancer therapy are unclear. The present work focused on addressing the role of mTOR/rictor in mTOR inhibitor-induced Akt activation and the impact of sustained Akt activation on mTOR-targeted cancer therapy. Thus, we have demonstrated that mTOR inhibitors increase Akt phosphorylation through a mechanism independent of mTO...

  3. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

    Helliwell, S. B.; Wagner, P.; Kunz, J.; Deuter-Reinhard, M.; Henriquez, R.; Hall, M. N.

    1994-01-01

    The Saccharomyces cerevisiae genes TOR1 and TOR2 were originally identified by mutations that confer resistance to the immunosuppressant rapamycin. TOR2 was previously shown to encode an essential 282-kDa phosphatidylinositol kinase (PI kinase) homologue. The TOR1 gene product is also a large (281 kDa) PI kinase homologue, with 67% identity to TOR2. TOR1 is not essential, but a TOR1 TOR2 double disruption uniquely confers a cell cycle (G1) arrest as does exposure to rapamycin; disruption of T...

  4. MH17: the Malaysian experience.

    Khoo, L S; Hasmi, A H; Abdul Ghani Aziz, S A; Ibrahim, M A; Mahmood, M S

    2016-04-01

    A disaster is a natural or man-made (or technological) hazard resulting in an event of substantial extent causing significant physical damage or destruction, loss of life, or drastic change to the environment. It is a phenomenon that can cause damage to life and property and destroy the economic, social and cultural life of the people; and overwhelms the capacity of the community to cope with the event. The recent tragic aviation accidents in 2014 involving Malaysia Airlines flights MH370 and MH17 shocked the world in an unprecedented manner. This paper focuses on the Malaysian experience in the MH17 mission in Ukraine as well as the first ever international Disaster Victim Identification (DVI) operation for the Malaysian DVI team. The DVI operations in Hilversum, the Netherlands were well described in stages. The Netherlands' Landelijk Team Forensische Opsporing as the lead DVI team in Hilversum operated systematically, ensuring the success of the whole mission. This paper discusses the lessons learned by the Malaysian team on proper DVI structure, inter- and intra-agency cooperation, facilities planning and set up, logistics and health and safety aspects, as well as effective communication and collaboration with other international delegates. Several issues and challenges faced by the Malaysian team were also documented. In addition, the authors shared views, opinions and recommendations for a more comprehensive DVI operation in the future.

  5. Inclusion in Malaysian Integrated Preschools

    Sukumaran, Sailajah; Loveridge, Judith; Green, Vanessa A.

    2015-01-01

    Inclusive education has been introduced through a number of policy developments in Malaysia over the last 10 years but there is little research investigating the extent and nature of inclusive education for preschoolers with special educational needs (SEN). This study surveyed both regular and special education teachers in Malaysian integrated…

  6. Historic day for Malaysian consumers.

    Kaur, S R

    1993-04-01

    The Malaysian Medical Association, the Malaysian Dental Association, the Malaysian Pharmaceutical Society, and the Federation of Malaysian Consumer Associations have introduced and endorsed the Charter for Patient Rights. The Charter recognized that health care is a basic human right, regardless of race, religion, social status, and ability to pay. Further, consumers have the right to seek medical care in both the public and private sectors. The Charter also includes the right to a second opinion, one's own medical records, and explanation before receiving any medical treatment and concerning the risks of treatment, compensation for negligence, and adequate information. Malaysia is the second Asian country to have such a charter, South Korea being the first. The UK also has a Patients Charter. The rest of Europe is also moving to adopt such a charter. The private sector, which serves only those who can afford them, provides most health care services in developing countries. Thus, a large private sector threatens the elderly, unemployed, rural poor, and the mentally ill in these countries. The supply of these services is a marketable commodity which physicians and health care professionals own and sell. The medical community has planned, formulated, implemented, and monitored health services in most of these countries. Therefore, the private sector is a major obstacle to health for all. The Charter helps to break down the barrier by informing both physicians and their patients of their rights and responsibilities.

  7. TOR

    National Oceanic and Atmospheric Administration, Department of Commerce — A tornado warning is issued by the local NWS Weather Forecast Office (WFO) when a tornado is indicated by the WSR-88D radar or sighted by spotters.

  8. Advanced Research of mTOR and Lung Carcinoid Tumors

    Zixuan ZHANG

    2013-01-01

    Full Text Available Mammalian target of rapamycin (mTOR, a main protein kinase in the phosphoinositide 3-kinase (PI3K/AKT/mTOR signaling pathway, is an important intracellular mediator involved in multiple celluar functions including proliferation, differentiation, apoptosis, tumorigenesis, and angiogenesis. Recently, the high expression of mTOR and mTOR-related kinase have been found in neuroendocrin tumors. Therefore, mTOR pathway represents an attractive target for new anticancer therapies except surgery.

  9. Evolutionarily conserved regulation of TOR signalling.

    Takahara, Terunao; Maeda, Tatsuya

    2013-07-01

    The target of rapamycin (TOR) is an evolutionarily conserved protein kinase that regulates cell growth in response to various environmental as well as intracellular cues through the formation of 2 distinct TOR complexes (TORC), TORC1 and TORC2. Dysregulation of TORC1 and TORC2 activity is closely associated with various diseases, including diabetes, cancer and neurodegenerative disorders. Over the past few years, new regulatory mechanisms of TORC1 and TORC2 activity have been elucidated. Furthermore, recent advances in the study of TOR inhibitors have revealed previously unrecognized cellular functions of TORC1. In this review, we briefly summarize the current understanding of the evolutionarily conserved TOR signalling from upstream regulators to downstream events.

  10. Endometriose torácica

    Filipa Costa

    2008-05-01

    Full Text Available Resumo: A endometriose torácica define-se pela presença de tecido endometrial no pulmão ou pleura e manifesta-se clinicamente por hemoptises cíclicas, pneumotórax ou hemotórax recorrente coincidentes com a menstruação. Tratando-se de uma patologia rara, nem sempre é considerada no diagnóstico diferencial quando se avaliam estas manifestações. Os exames complementares de diagnóstico geralmente não revelam alterações específicas, sendo o diagnóstico feito com base na história clínica. A chave do diagnóstico são os sintomas catameniais, sendo fundamental realizar uma história clínica minuciosa para chegar atempadamente ao diagnóstico correcto. O tratamento hormonal e a cirurgia são as duas alternativas terapêuticas para esta patologia.Os autores descrevem o caso clínico de uma doente de 27 anos que surge com um quadro de hemoptises catameniais. Os exames complementares de diagnóstico realizados foram inconclusivos. Baseado na história clínica, assumiuse o diagnóstico de endometriose pulmonar e iniciouse tratamento com contraceptivos orais com resolução total dos sintomas.A propósito do caso clínico, os autores fazem uma revisão das principais manifestações clínicas, da patogénese, do diagnóstico e do tratamento da endometriose torácica.Rev Port Pneumol 2008; XIV (3: 427-435 Abstract: Thoracic endometriosis is defined by the presence of endometrial tissue in the lungs or pleura, and is characterised by cyclic hemoptysis or recurrent hemothorax or pneumothorax occurring with the menstruation. Being a rare clinical entity, it is not always considered in the differential diagnosis when these symptoms are evaluated. The exams performed during the diagnostic work-up frequently show non-specific alterations, however a presumptive diagnosis can be made based on the typical clinical history. The key to the diagnosis are the catamenial symptoms, so a thorough clinical history is essential to promptly reach the

  11. Endometriose torácica

    Filipa Costa

    2008-05-01

    Full Text Available Resumo: A endometriose torácica define-se pela presença de tecido endometrial no pulmão ou pleura e manifesta--se clinicamente por hemoptises cíclicas, pneumotórax ou hemotórax recorrente coincidentes com a menstruação. Tratando-se de uma patologia rara, nem sempre é considerada no diagnóstico diferencial quando se avaliam estas manifestações. Os exames complementares de diagnóstico geralmente não revelam alterações específicas, sendo o diagnóstico feito com base na história clínica. A chave do diagnóstico são os sintomas catameniais, sendo fundamental realizar uma história clínica minuciosa para chegar atempadamente ao diagnóstico correcto. O tratamento hormonal e a cirurgia são as duas alternativas terapêuticas para esta patologia.Os autores descrevem o caso clínico de uma doente de 27 anos que surge com um quadro de hemoptises catameniais. Os exames complementares de diagnóstico realizados foram inconclusivos. Baseado na história clínica, assumiu-se o diagnóstico de endometriose pulmonar e iniciou-se tratamento com contraceptivos orais com resolução total dos sintomas.A propósito do caso clínico, os autores fazem uma revisão das principais manifestações clínicas, da patogénese, do diagnóstico e do tratamento da endometriose torácica. Abstract: Thoracic endometriosis is defined by the presence of endometrial tissue in the lungs or pleura, and is characterised by cyclic hemoptysis or recurrent hemothorax or pneumothorax occurring with the menstruation. Being a rare clinical entity, it is not always considered in the differential diagnosis when these symptoms are evaluated. The exams performed during the diagnostic work-up frequently show nonspecific alterations, however a presumptive diagnosis can be made based on the typical clinical history. The key to the diagnosis are the catamenial symptoms, so a thorough clinical history is essential to promptly reach the correct diagnosis. Hormonal treatment and

  12. SPORTS WATCHING CULTURE AMONG MALAYSIANS

    Gunathevan Elumalai

    2015-12-01

    Full Text Available Background: Ardent sports watching will lead an individual to engage in sports and recreational activities continuously, while it also creates a sports culture among Malaysians. Sports watching culture is actually an intellectual activity. It is capable of evaluating behaviour, moral values and the level of appreciation of every spectator. Methods: This survey was conducted to identify the sports viewing culture among Malaysians. A cluster sampling method was used to select 6000 respondents from 30 million Malaysian population. Respondents were selected from urban (50% and rural areas (50%. Ethnically 56% were Malays, Sarawak and Sabah natives were 11%, Chinese 25% and finally Indians 7%. The respondents age categories were 12 to 19 years (30%, 20 to 25 years (50%, 56 and above (20%. A questionnaire developed by the research team was used to collect data. The quantitative data were analysed using Statistical Package for Social Sciences (SPSS version 21.0 for windows. Results: The findings indicate that from 5864 respondents who answered the questionnaire in full, a total of 4553 people or 77.6% watch sporting events, while a total of 1311 people or 22.4% have stated not watching any sports activities. Comparison by gender showed that 85.2% of the 2482 males watch sports events while among the female 70.2% of the 2071 watch sports events. In the category of those who do not watch, the female are higher at 29.8% than the males at 14.8%. In terms of ethnicity the Malays 80.2%. Chinese 64.6%, Indians 81.9%, natives of Sabah 94.0%, natives of Sarawak 77.6% like to watch sports events. Residential locations showed no significant differences as 78.7% of urban respondents watch sports events compared to 76.8% of rural communities. Conclusion: The findings indicated that majority of Malaysians having fun in watching sports activities. Gender still plays a role in the involvement and enjoyment of sports events either as a player or supporter. Ethnicity

  13. Biotechnology issues in four Malaysian mainstream newspapers ...

    Biotechnology has been identified as the new engine of growth for the transformation of Malaysia into a developed nation by 2020. The objective of this paper is to analyze the impact of National Policy on biotechnology on media reporting in four Malaysian newspapers. Towards this end, a content analysis of four Malaysian ...

  14. Rhythmic patterning in Malaysian and Singapore English.

    Tan, Rachel Siew Kuang; Low, Ee-Ling

    2014-06-01

    Previous work on the rhythm of Malaysian English has been based on impressionistic observations. This paper utilizes acoustic analysis to measure the rhythmic patterns of Malaysian English. Recordings of the read speech and spontaneous speech of 10 Malaysian English speakers were analyzed and compared with recordings of an equivalent sample of Singaporean English speakers. Analysis was done using two rhythmic indexes, the PVI and VarcoV. It was found that although the rhythm of read speech of the Singaporean speakers was syllable-based as described by previous studies, the rhythm of the Malaysian speakers was even more syllable-based. Analysis of the syllables in specific utterances showed that Malaysian speakers did not reduce vowels as much as Singaporean speakers in cases of syllables in utterances. Results of the spontaneous speech confirmed the findings for the read speech; that is, the same rhythmic patterning was found which normally triggers vowel reductions.

  15. A TorPath to TorCoin: Proof-of-Bandwidth Altcoins for Compensating Relays

    2014-07-18

    TorCoin by checking the blockchain . Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of...of occasional colluding circuits, TorCoin also limits the number of coins each circuit can mine. This coin number is included in the blockchain , so it

  16. Nutrient sensing and TOR signaling in yeast and mammals.

    González, Asier; Hall, Michael N

    2017-02-15

    Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR-related diseases. © 2017 The Authors.

  17. Spoiled Onions: Exposing Malicious Tor Exit Relays

    Winter, Philipp; Lindskog, Stefan

    2014-01-01

    Several hundred Tor exit relays together push more than 1 GiB/s of network traffic. However, it is easy for exit relays to snoop and tamper with anonymised network traffic and as all relays are run by independent volunteers, not all of them are innocuous. In this paper, we seek to expose malicious exit relays and document their actions. First, we monitored the Tor network after developing a fast and modular exit relay scanner. We implemented several scanning modules for detecting common attac...

  18. The Challenges of Malaysian Dry Ports Development

    Jagan Jeevan

    2015-03-01

    Full Text Available This paper examines the functions and challenges of dry ports development in Malaysia through 11 face-to-face interviews with dry port stakeholders. The findings reveal that Malaysian dry ports are developed to accelerate national and international business, to activate intermodalism in the nation, to promote regional economic development and to enhance seaport competitiveness. Malaysian dry ports perform the function of transport and logistics, information processing, seaports and value-added services. Challenges facing Malaysian dry ports include insufficient railway tracks, unorganized container planning on the rail deck, highly dependent on single mode of transportation, poor recognition from the seaport community, and competition from localized seaports. This paper further indicates strategies for coping with these challenges and identifies future opportunities for Malaysian dry ports development.

  19. Local learning processes in Malaysian industry

    Wangel, Arne

    1999-01-01

    Local learning processes are a vital part of any dynamic assimilation of transferred technology. The paper raises the question about the interaction between the training paradigms, which transnational corporations introduce in their subsidiaries in Malaysia and the specific basis for learning...... of Malaysian labour. Experiences from Malaysian industry indicate that local learning processes are shaped, among other things, by the concept of knowledge in a particular training programme, labour market structures, and learning cultures....

  20. Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation.

    Baldin, Clara; Valiante, Vito; Krüger, Thomas; Schafferer, Lukas; Haas, Hubertus; Kniemeyer, Olaf; Brakhage, Axel A

    2015-07-01

    The Tor (target of rapamycin) kinase is one of the major regulatory nodes in eukaryotes. Here, we analyzed the Tor kinase in Aspergillus fumigatus, which is the most important airborne fungal pathogen of humans. Because deletion of the single tor gene was apparently lethal, we generated a conditional lethal tor mutant by replacing the endogenous tor gene by the inducible xylp-tor gene cassette. By both 2DE and gel-free LC-MS/MS, we found that Tor controls a variety of proteins involved in nutrient sensing, stress response, cell cycle progression, protein biosynthesis and degradation, but also processes in mitochondria, such as respiration and ornithine metabolism, which is required for siderophore formation. qRT-PCR analyses indicated that mRNA levels of ornithine biosynthesis genes were increased under iron limitation. When tor was repressed, iron regulation was lost. In a deletion mutant of the iron regulator HapX also carrying the xylp-tor cassette, the regulation upon iron deprivation was similar to that of the single tor inducible mutant strain. In line, hapX expression was significantly reduced when tor was repressed. Thus, Tor acts either upstream of HapX or independently of HapX as a repressor of the ornithine biosynthesis genes and thereby regulates the production of siderophores. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Viral factor TAV recruits TOR/S6K1 signalling to activate reinitiation after long ORF translation

    Schepetilnikov, Mikhail; Kobayashi, Kappei; Geldreich, Angèle; Caranta, Carole; Robaglia, Christophe; Keller, Mario; Ryabova, Lyubov A

    2011-01-01

    The protein kinase TOR (target-of-rapamycin) upregulates translation initiation in eukaryotes, but initiation restart after long ORF translation is restricted by largely unknown pathways. The plant viral reinitiation factor transactivator–viroplasmin (TAV) exceptionally promotes reinitiation through a mechanism involving retention on 80S and reuse of eIF3 and the host factor reinitiation-supporting protein (RISP) to regenerate reinitiation-competent ribosomal complexes. Here, we show that TAV function in reinitiation depends on physical association with TOR, with TAV–TOR binding being critical for both translation reinitiation and viral fitness. Consistently, TOR-deficient plants are resistant to viral infection. TAV triggers TOR hyperactivation and S6K1 phosphorylation in planta. When activated, TOR binds polyribosomes concomitantly with polysomal accumulation of eIF3 and RISP—a novel and specific target of TOR/S6K1—in a TAV-dependent manner, with RISP being phosphorylated. TAV mutants defective in TOR binding fail to recruit TOR, thereby abolishing RISP phosphorylation in polysomes and reinitiation. Thus, activation of reinitiation after long ORF translation is more complex than previously appreciated, with TOR/S6K1 upregulation being the key event in the formation of reinitiation-competent ribosomal complexes. PMID:21343906

  2. Fingerprinting Keywords in Search Queries over Tor

    Oh Se Eun

    2017-10-01

    Full Text Available Search engine queries contain a great deal of private and potentially compromising information about users. One technique to prevent search engines from identifying the source of a query, and Internet service providers (ISPs from identifying the contents of queries is to query the search engine over an anonymous network such as Tor.

  3. Red de anonimización TOR y cibermercados negros

    González Muñoz, Ignacio

    2018-01-01

    El trabajo se centra en el entorno de la red Tor. Se describe qué es Tor, sus componentes y el funcionamiento de la red. Se realiza un estudio de los métodos de desanonimización de usuarios, así como los ataques que puede sufrir la red. También se analizan los mercados ocultos que hay en Tor y las criptomonedas que se utilizan en estos mercados. El treball es centra en l'entorn de la xarxa Tor. Es descriu què és Tor, els seus components i el funcionament de la xarxa. Es realitza un estudi ...

  4. The reprocessing of fast reactor fuels - the TOR project

    Calame-Longjean, A.; Le Bouhellec, J.; Schwob, Y.

    1982-01-01

    A description is given of development work on the proposed new French facility for the reprocessing of fast reactor fuel. This is the TOR facility (Traitement des Oxydes Rapides). Block diagrams give details of the TOR project as a whole and of the main line and R and D line of the TOR 1 facility which is a new works devoted to the head of the process. Modifications to existing plant which will form the TOR 2 and TOR 3 facilities are also described. (U.K.)

  5. Suicidal ideation among Malaysian adolescents.

    Ahmad, NoorAni; Cheong, Siew Man; Ibrahim, Nurashikin; Rosman, Azriman

    2014-09-01

    Adolescence is the time of greatest risk for the first onset of suicidal behaviors. This study aimed to identify the risk and protective factors associated with suicidal ideation among Malaysian adolescents. Data from the 2012 Malaysia Global School-based Student Health Survey, a nationwide study using a 2-stage cluster sampling design, were analyzed. The survey used a self-administered validated bilingual questionnaire and the Depression Anxiety and Stress Scale. The prevalence of suicidal ideation was 7.9%. Analysis revealed that suicidal ideation was positively associated with depression, anxiety, stress, substance use, being bullied, and being abused at home, either physically or verbally. In addition, suicidal ideation was significantly higher among females and among the Indians and Chinese. Having close friends and married parents were strongly protective against suicidal ideation. Understanding the risk and protective factors is important in providing comprehensive management for suicidal ideation. © 2014 APJPH.

  6. PeerFlow: Secure Load Balancing in Tor

    Johnson Aaron

    2017-04-01

    Full Text Available We present PeerFlow, a system to securely load balance client traffic in Tor. Security in Tor requires that no adversary handle too much traffic. However, Tor relays are run by volunteers who cannot be trusted to report the relay bandwidths, which Tor clients use for load balancing. We show that existing methods to determine the bandwidths of Tor relays allow an adversary with little bandwidth to attack large amounts of client traffic. These methods include Tor’s current bandwidth-scanning system, TorFlow, and the peer-measurement system EigenSpeed. We present an improved design called PeerFlow that uses a peer-measurement process both to limit an adversary’s ability to increase his measured bandwidth and to improve accuracy. We show our system to be secure, fast, and efficient. We implement PeerFlow in Tor and demonstrate its speed and accuracy in large-scale network simulations.

  7. Selfrando: Securing the Tor Browser against De-anonymization Exploits

    Conti Mauro

    2016-10-01

    Full Text Available Tor is a well-known anonymous communication system used by millions of users, including journalists and civil rights activists all over the world. The Tor Browser gives non-technical users an easy way to access the Tor Network. However, many government organizations are actively trying to compromise Tor not only in regions with repressive regimes but also in the free world, as the recent FBI incidents clearly demonstrate. Exploiting software vulnerabilities in general, and browser vulnerabilities in particular, constitutes a clear and present threat to the Tor software. The Tor Browser shares a large part of its attack surface with the Firefox browser. Therefore, Firefox vulnerabilities (even patched ones are highly valuable to attackers trying to monitor users of the Tor Browser.

  8. Hypothalamic mTOR signaling regulates food intake.

    Cota, Daniela; Proulx, Karine; Smith, Kathi A Blake; Kozma, Sara C; Thomas, George; Woods, Stephen C; Seeley, Randy J

    2006-05-12

    The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that regulates cell-cycle progression and growth by sensing changes in energy status. We demonstrated that mTOR signaling plays a role in the brain mechanisms that respond to nutrient availability, regulating energy balance. In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus. Central administration of leucine increases hypothalamic mTOR signaling and decreases food intake and body weight. The hormone leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin's anorectic effect. Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake.

  9. Sulfur availability regulates plant growth via glucose-TOR signaling.

    Dong, Yihan; Silbermann, Marleen; Speiser, Anna; Forieri, Ilaria; Linster, Eric; Poschet, Gernot; Allboje Samami, Arman; Wanatabe, Mutsumi; Sticht, Carsten; Teleman, Aurelio A; Deragon, Jean-Marc; Saito, Kazuki; Hell, Rüdiger; Wirtz, Markus

    2017-10-27

    Growth of eukaryotic cells is regulated by the target of rapamycin (TOR). The strongest activator of TOR in metazoa is amino acid availability. The established transducers of amino acid sensing to TOR in metazoa are absent in plants. Hence, a fundamental question is how amino acid sensing is achieved in photo-autotrophic organisms. Here we demonstrate that the plant Arabidopsis does not sense the sulfur-containing amino acid cysteine itself, but its biosynthetic precursors. We identify the kinase GCN2 as a sensor of the carbon/nitrogen precursor availability, whereas limitation of the sulfur precursor is transduced to TOR by downregulation of glucose metabolism. The downregulated TOR activity caused decreased translation, lowered meristematic activity, and elevated autophagy. Our results uncover a plant-specific adaptation of TOR function. In concert with GCN2, TOR allows photo-autotrophic eukaryotes to coordinate the fluxes of carbon, nitrogen, and sulfur for efficient cysteine biosynthesis under varying external nutrient supply.

  10. Assessing cultural intelligence of Malaysian expatriates in Netherlands

    Using purposive sampling method, a total of 320 questionnaires were distributed via email to Malaysian expatriates in Hague, Netherlands. Results from multiple regression analysis indicate that personality traits of agreeableness, openness and extraversion are significant to Malaysian expatriate's cultural intelligence.

  11. Internalization of Malaysian mathematical and computer science journals

    Zainab, A. N.

    2008-01-01

    The internationalization characteristics of two Malaysian journals, Bulletin of the Malaysian Mathematical Sciences Society ( indexed by ISI) and the Malaysian Journal of Computer Science ( indexed by Inspec and Scopus) is observed. All issues for the years 2000 to 2007 were looked at to obtain the following information, (i) total articles published between 2000 and 2007; (ii) the distribution of foreign and Malaysian authors publishing in the journals; (iii) the distribution of articles by c...

  12. Heysham II/Torness AGR core integrity

    Birch, A.L.; Hampson, J.D.

    1985-01-01

    The design and construction process for the Heysham II/Torness AGR core structures is presented. The design intent utilizing all past experience in designing and building AGR core structures is described. The major aspects of the design criteria and the design conditions are outlined to demonstrate how the integrity of the Heysham II/Torness core is assured. Since no recognized codes of practice for graphite core design exist, the National Nuclear Corporation (NNC) have conceived design criteria utilizing reserve factors based on their design experience. Target reserve factors are defined for particular loading conditions including the ultimate 'safe-shutdown earthquake'. The substantial programme of computer analysis and RandD work to substantiate the design, including seismic qualification, is described. In keeping with their responsibility for the detailed core structure design and the fuel path geometry (guide tube system), NNC attach great importance to design/manufacture/construction liaison, which is demonstrated in the quality assurance section. (author)

  13. Torness computer system turns round data

    Dowler, E.; Hamilton, J.

    1989-01-01

    The Torness nuclear power station has two advanced gas-cooled reactors. A key feature is the distributed computer system which covers both data processing and auto-control. The complete computer system has over 80 processors with 45000 digital and 22000 analogue input signals. The on-line control and monitoring systems includes operating systems, plant data acquisition and processing, alarm and event detection, communications software, process management systems and database management software. Some features of the system are described. (UK)

  14. Torness delay is storing up trouble

    Cavenagh, Andrew.

    1994-01-01

    A recent decision by the Scottish Office to delay planning permission for the construction of a 50 million dry store for spent nuclear fuel at Torness Power Station is proving frustrating and inexplicable to many in the nuclear industry. The possible reasons for this apparent about face in government policy on spent fuel management are debated and the economic ramifications of the decision for British Nuclear Fuels Limited (BNFL), if the store were to go ahead, are outlined. (UK)

  15. CHOLERA EL-TOR EN IRAN

    M. Ghodssi

    1969-01-01

    Full Text Available The bacteriological analysis shows that we have been confronted with the ELTor type, and only that type, until the end of the epidemic.The clinical study presents the symptoms of the real cholera with all its grievous consequences.The epidemiological supertnisicn stales that the El..Tor cholera is not agressiveat all in town areas whereas it presents its usual aspect in country areas, because of a lack of hygiene. there.That disease can be completely cured if the balance between the electrolytesis quickly restored.The disease was all the more dreadful since it came as a surprise and spread from one province to the other.L'examen bacteriologique montrc qu'il s'agit du type EI_ Tor et uniquement du meme type jusqu'a la fin de l'epldemie.La surveillance epidemiologique constate que Ie cholera EI_Tor n'cst nullement agressif dans Ie milieu urbain; mais qu'H revet l'aspect classique dans les milieuxruraux, depourvus d'hyglene.La maludic est totalement guerissablc a condition que l'equilibre des electrolytes so it rapidement retabli. L'evenement a tHe maladie se repandit d'une12

  16. PRELIMINARY REVISIONS OF SOME GENERA OF MALAYSIAN PAPILIONACEAE II

    MS van Meeuwen

    2014-01-01

    Full Text Available The revisions or notes have been prepared by Miss M. S. van Meeuwen, except for those of Pseudarthria and Sophora by C. G. G. J. van Steenis, and Tephrosia by J. Stemmerik. In Alysicarpus 4 species are distinguished in Malaysia; a key, synonymy, and discussion are given.Lourea Desv., being a homonym, has, according to Dr. Bakhuizen van den Brink, to be replaced by Christia; a key and discussion is given of 4 Malaysian species; 5 new combinations are proposed. Under Desmodium the variability of D. heterocarpon (L. DC. and its full synonymy are discussed; one new variety is proposed; an enumeration of specimens of both varieties is given. D. ormooarpoides DC. and D. zonatum Miq. are two sharply distinct species which have been confused in the past; a key, synonyms, discussion, and enumeration of specimens ;; j are provided. The discrimination of D. sequax Wall, and D. viegaphyllum Zoll. is discussed and their synonymy given; specimens have been enumerated. Distribution is given of D. scorpiurus (Sw. Desv. and D. tor-tuosum (Sw.   DC. Psoraleai is revised for Malaysia where 4 species are recorded and keyed out; a fifth species must remain dubious, as the type could not be traced in the Paris Herbarium. Of Pseudarthria only one species occurs in Malaysia; its synonymy and distribution is given.Sophora longipes Merr.; an endemic species from the Philippines, is recorded for Timor. Of Tephro&ia maculata M. & P., from Papua, the synonymy is given and specimens enumerated; T. brachystachys Laut. & K. Seh. is reduced. Notes and distribution are given of T. zollingeri Backer. For T. mollie . Val., a later homonym, the new name T. papuana is proposed.

  17. Malaysian Affordability Housing Policies Revisited

    Samad Diwa

    2016-01-01

    Full Text Available Housing has always been a significant aspiration of family expression and distinctly priciest investment by household. It plays a momentous role in the country’s economy and so central to the societal well-being that is emplaced in the United Nation Universal declaration of Human rights. Yet in developed and developing world alike, cities struggle to provide decent housing for lower and middle income population. The provision of affordable housing is a major policy concern around the world with Malaysia being no exception; rising income hardly keep pace with price hike of housing unit and housing interventions has majorly concentrated on demand side leading to a non-responsive supply sector. Therefore, this paper highlights affordable housing issues pertaining Malaysia. It formulates Malaysian Map of affordability and conducts an evaluation of global housing schemes to better identify policy priorities for Malaysia. It’s significant to harmonize supply and demand side factors in the housing market to ensure that housing supply fits the needs of citizens based on the location, price and target group. In case of Malaysia supply oriented initiative are of urgency in short and medium run. This must be supported by long term demand side schemes in parallel. Convergence of these two factors is essential for a balanced equilibrium and obtaining affordability.

  18. Prediction of Malaysian monthly GDP

    Hin, Pooi Ah; Ching, Soo Huei; Yeing, Pan Wei

    2015-12-01

    The paper attempts to use a method based on multivariate power-normal distribution to predict the Malaysian Gross Domestic Product next month. Letting r(t) be the vector consisting of the month-t values on m selected macroeconomic variables, and GDP, we model the month-(t+1) GDP to be dependent on the present and l-1 past values r(t), r(t-1),…,r(t-l+1) via a conditional distribution which is derived from a [(m+1)l+1]-dimensional power-normal distribution. The 100(α/2)% and 100(1-α/2)% points of the conditional distribution may be used to form an out-of sample prediction interval. This interval together with the mean of the conditional distribution may be used to predict the month-(t+1) GDP. The mean absolute percentage error (MAPE), estimated coverage probability and average length of the prediction interval are used as the criterions for selecting the suitable lag value l-1 and the subset from a pool of 17 macroeconomic variables. It is found that the relatively better models would be those of which 2 ≤ l ≤ 3, and involving one or two of the macroeconomic variables given by Market Indicative Yield, Oil Prices, Exchange Rate and Import Trade.

  19. Factors Affecting Hypertension among the Malaysian Elderly

    Eshkoor, Sima Ataollahi; Hamid, Tengku Aizan; Shahar, Suzana; Ng, Chee Kyun; Mun, Chan Yoke

    2016-01-01

    Hypertension is a common chronic disease in the elderly. This study aimed to determine the effects of age, ethnicity, gender, education, marital status, nutritional parameters, and blood elements on the risk of high blood pressure in the Malaysian elderly. This research was conducted on a group of 2322 non-institutionalized Malaysian elderly. The hierarchy binary logistic regression analysis was applied to estimate the risk of hypertension in respondents. Approximately, 45.61% of subjects had hypertension. The findings indicated that the female gender (Odds ratio (OR) = 1.54), an increase in body weight (OR = 1.61), and an increase in the blood levels of albumin (OR = 1.51), glucose (OR = 1.92), and triglycerides (OR = 1.27) significantly increased the risk of hypertension in subjects (p Malaysian elderly. In addition, an increase in both dietary carbohydrates and blood cholesterol level decreased hypertension in subjects. PMID:29367559

  20. Repositioning Strategy for Malaysian Companies Internationalization

    Ismi Rajiani

    2013-04-01

    Full Text Available The rise of the emerging-market countries offers both developing and developed countries a unique opportunity to gain the benefits of a truly international economy. Consequently, it is imper- ative to advance our knowledge of emerging-market countries MNC emergence and competitive- ness including Malaysian firms on how will they position their products strategically. Based on the framework of Porter’s Generic Strategy, this paper is composed of price/ volume segments and im- pacts on product strategy theory. The aim is to identify crucial triggering cues and focus areas for Malaysian companies and measure what role these play in different segments. This study argues that some Malaysian companies will reposition themselves strategically when internationalizing and that they will focus on other factors or triggering cues when doing so not merely adapting the prevalent price leadership strategy.

  1. Managing Political Information: A Malaysian Perspective

    Jamilah Ahmad

    2010-07-01

    Full Text Available In the development of democratization and the expression of civil and political rights of Malaysian citizens, the pattern of control developed by the regime that is currently in power (Barisan Nasional for the last 50 years in the mass media began to reap the resistance and tend to be ineffective. Malaysian citizens began to demand the Malaysian government to change the pattern of political information management. In addition, the mass media alone is expected to play a more significant role as an intermediary agent in supporting the process of transparency and accountability of government policy. This article shows that the openness of public information is a prerequisite for political democracy in Malaysia to help the government minimize the mis-management of governance policies, especially in finance and resource management.

  2. Anonymity communication VPN and Tor: a comparative study

    Ramadhani, E.

    2018-03-01

    VPN and Tor is a technology based on anonymity communication. These two technologies have their advantage and disadvantage. The objective of this paper is to find the difference between VPN and Tor technologies by comparing their security of communication on the public network based on the CIA triad concept. The comparative study in this paper is based on the survey method. At last, the result of this paper is a recommendation on when to use a VPN and Tor to secure communication

  3. TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease.

    Blenis, John

    2017-09-21

    Michael N. Hall is this year's recipient of the Lasker Basic Medical Research Award for the identification of the target of rapamycin, TOR. TOR is a master regulator of the cell's growth and metabolic state, and its dysregulation contributes to a variety of diseases, including diabetes, obesity, neurodegenerative disorders, aging, and cancer, making the TOR pathway an attractive therapeutic target. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  4. Drivers for Cleaner Production in Malaysian Industry

    Wangel, Arne

    2003-01-01

    This working paper tries to piece together information on regulatory initiatives promoting cleaner production (CP) in Malaysian industry, as well as points of discussion on environmental performance in the sector. It draws upon initial data collection by the team of the research project ‘A Study...... on Promotion and Implementation of Cleaner Production Practices in Malaysian Industry - Development of a National Program and Action Plan for Promotion of Cleaner Production’, which is coordinated by Institute of Environmental and Resource Management, Universiti Teknologi Malaysia; the objective of this study...... is ‘to formulate, establish and develop a comprehensive "National Cleaner Production Promotion Program" for Malaysia’....

  5. Nuclear Security in Action at Malaysian Borders

    Dahlstrom Danielle

    2013-01-01

    ''For Malaysia, trade has to be a transparent'', explained Raja Adnan, the Director General of the Malaysian Atomic Energy Licensing Board (AELB). ''Goods are imported and exported, not just between two countries, but are in transit between several countries. Nuclear security measures help to guarantee open trade and makes sure that everyone is trading responsibly,'' emphasized Adnan. Officials from AELB prepare for a joint Indonesian-Malaysian exercise in effective border control by reviewing their national standard operating procedures (SOPs) on nuclear security, which were developed in close coordination with the IAEA

  6. Food irradiation development: Malaysian perspective

    Zainon Othman

    1997-01-01

    Malaysia recognised the potential of food irradiation as a technology that can contribute to solving some preservation problems associated with local agricultural produce. Research studies in this technology were initiated in late 1970s and since 1985, all activities pertaining to R and D applications, adoption and technology transfer of food irradiation were coordinated by The National Working Committee on Food Irradiation which comprises of members from research institutes, universities, regulatory agencies and consumer association. To date, technical feasibility studies conducted on 7 food items / agricultural commodities of economic importance demonstrated the efficacy of irradiation in extending shelf-life, improving hygienic quality and overcoming quarantine barriers in trade. Presently, 1 multipurpose Co-60 irradiator (I MCi), 2 gammacells and an electron beam machine (3 MeV) are available at MINT for research and commercial runs. The Malaysian Standards on Guidelines for Irradiation of Food was formulated in 1992 to facilitate application by local food industries. However, Malaysia has not yet commercially adopt the technology. Among many factors contributing to the situation is the apparent lack of interest by food industries and consumers. Consumer attitude study indicated majority of consumers are still unaware of the benefits of the technology and expressed concern for the safety of process and irradiated products due to limited knowledge and adverse publicity by established consumer groups. Although the food processors indicate positive attitude towards food irradiation, there remain many factors delaying its commercial application such as limited knowledge, cost-benefit, logistics and consumer acceptance. On the regulatory aspect, approval is required from the Director-General of Ministry of Health prior to application of irradiation on food and sale of irradiated food but efforts are being geared towards approving irradiation of certain food

  7. State of progress in Malaysian plant Taxonomy

    NN,

    1948-01-01

    Dr H.C.D. de Wit started a revision of Malaysian Bauhinia, this being part of his work on the Caesalpiniaceae of Malaysia; he is working in the Eijksherbarium, Leyden, Holland. Mr R.A. Blakelock, is revising the genus Evonymus at the Roy. Bot. Gardens, Kew-Surrey.

  8. Educational Transition of East Malaysian Distance Learners.

    Saw, K. G.; Awang, M. N.; Idrus, R. M.; Atan, H.; Azli, N. A.; Jaafar, I.; Rahman, Z. A.; Latiff, Z. A.

    1999-01-01

    Describes results of a study of the changing perceptions of East Malaysian distance learners studying at the Universiti Sains Malaysia. Highlights include students' perceptions of their study skills; and the impact of their studies on other areas of their life, including social obligations, recreation, families, health, finances, work, and…

  9. Malaysian Students' Motivation towards Physics Learning

    Saleh, Salmiza

    2014-01-01

    The purpose of this survey study was to examine the level of Malaysian students' motivation with regards to the learning of Physics at the secondary school level, and its influencing factors. The study was carried out on 337 Form Four students who took Physics as a subject, from six schools in a northern state of Malaysia--three from urban areas,…

  10. Malaysian Children's Attitudes towards Learning Music

    Ghazali, Ghaziah Mohd.; McPherson, Gary E.

    2009-01-01

    A sample of 1060 Malaysian children were surveyed in order to examine differences in their motivation to study music in school and to learn a musical instrument outside of school. Adopting the expectancy-value motivation theory, the children were asked questions concerning their perception of music as being important, useful, interesting,…

  11. Biotechnology issues in four Malaysian mainstream newspapers

    Jane

    2011-09-30

    Sep 30, 2011 ... Biotechnology has been identified as the new engine of growth for the transformation of Malaysia into a developed nation by 2020. The objective of this paper is to analyze the impact of National Policy on biotechnology on media reporting in four Malaysian newspapers. Towards this end, a content analysis.

  12. Prepositions and ESL Learners: the Malaysian Scenario

    Norwati Roslim

    2014-01-01

    Full Text Available This article presents a review of the literature on prepositions with a focus on definitions and main difficulties faced by Malaysian students. It further highlights recommendations about the role of syllabus designers, textbook writers and teachers in meeting these challenges. It is hoped that this article could provide a platform for any further studies on prepositions.

  13. Malaysian water sector reform : policy and performance

    Kim, C.T.

    2012-01-01

    One of the measures that can help developing countries in meeting Target 10 of the Millennium Development Goals – halving the number of people without access to water and adequate sanitation by 2015 – is through a water sector reform. In this research the Malaysian water sector reform is

  14. Eclectic Model in the Malaysian Education System

    Othman, Nooraini; Mohamad, Khairul Azmi; Ilmuwan, Yayasan

    2011-01-01

    The present work aims at analysing the adoption of eclectic model in the Malaysian education system. The analysis is specifically looked from the angle of Islam and the Muslims. Malaysia has a long history of education system developments, from pre to post independence of the country. From what was initially traditional, modernity later came to…

  15. Boiler inspection manipulator for Torness Power Station

    Carrey, R.T.A.; Playle, M.J.

    1996-01-01

    In-service inspection at Torness Advanced Gas-cooled Reactor is achieved, via penetrations above and below the core area and boilers and through eight circulator penetrations for inspection of the sub-diagrid area. A manipulator is described which can access the area above the reactor core via any of these eight peripheral penetrations. The design and fabrication of the manipulator has led to innovation with a number of possible solutions being tendered. In reactor deployment of the successful design is expected in early 1997. (UK)

  16. Macht auf das Tor! - Opens the gate!

    Claudemir de Quadros

    2011-09-01

    Full Text Available Macht auf das Tor! (Abra o portão foi publicado, possivelmente, na primeira metade do século 20. Editado por Max Dirkschneider, Raimund Heuler e Felix Oberborbeck, apresenta músicas, rimas, piadas, jogos e canções.A edição apresentada nesse espaço é de um livro que pertence à família de Carolina Drebes, estudante do curso de Pedagogia do Centro Universitário Franciscano, Santa Maria/RS.

  17. Boiler inspection manipulator for Torness Power Station

    Carrey, R.T.A.; Yule, I.Y.; Sibson, S.; Playle, M.J.

    1996-01-01

    The Advanced Gas-cooled Reactors at Torness and Heysham 2 are provided with dedicated access for remote inspection equipment. These in-service inspection (ISI) accesses comprise 12 penetrations above the core for inspection of the above core area and boilers, 12 below core penetrations for inspection of the lower boiler area and access through any of the 8 gas circulator penetrations for inspection of the sub-diagrid area. This paper describes a manipulator which will access the reactor from above the core via any of the 8 peripheral penetrations. (UK)

  18. Inactivation of Tor proteins affects the dynamics of endocytic proteins ...

    Tor2 is an activator of the Rom2/Rho1 pathway that regulates -factor internalization. Since the recruitment of endocytic proteins such as actin-binding proteins and the amphiphysins precedes the internalization of -factor, we hypothesized that loss of Tor function leads to an alteration in the dynamics of the endocytic ...

  19. mTOR dysregulation and tuberous sclerosis-related epilepsy

    Curatolo, Paolo; Moavero, Romina; van Scheppingen, Jackelien; Aronica, Eleonora

    2018-01-01

    The mammalian target of rapamycin (mTOR) pathway has emerged as a key player for proper neural network development, and it is involved in epileptogenesis triggered by both genetic or acquired factors. Areas covered. The robust mTOR signaling deregulation observed in a large spectrum of epileptogenic

  20. Role of mTOR Inhibitors in Kidney Disease

    Moto Kajiwara

    2016-06-01

    Full Text Available The first compound that inhibited the mammalian target of rapamycin (mTOR, sirolimus (rapamycin was discovered in the 1970s as a soil bacterium metabolite collected on Easter Island (Rapa Nui. Because sirolimus showed antiproliferative activity, researchers investigated its molecular target and identified the TOR1 and TOR2. The mTOR consists of mTOR complex 1 (mTORC1 and mTORC2. Rapalogues including sirolimus, everolimus, and temsirolimus exert their effect mainly on mTORC1, whereas their inhibitory effect on mTORC2 is mild. To obtain compounds with more potent antiproliferative effects, ATP-competitive inhibitors of mTOR targeting both mTORC1 and mTORC2 have been developed and tested in clinical trials as anticancer drugs. Currently, mTOR inhibitors are used as anticancer drugs against several solid tumors, and immunosuppressive agents for transplantation of various organs. This review discusses the role of mTOR inhibitors in renal disease with a particular focus on renal cancer, diabetic nephropathy, and kidney transplantation.

  1. Glacial modification of granite tors in the Cairngorms, Scotland

    Hall, A.M.; Phillips, W.M.

    2006-01-01

    A range of evidence indicates that many granite tors in the Cairngorms have been modified by the flow of glacier ice during the Pleistocene. Comparisons with SW England and the use of a space-time transformation across 38 tor groups in the Cairngorms allow a model to be developed for progressive glacial modification. Tors with deeply etched surfaces and no, or limited, block removal imply an absence of significant glacial modification. The removal of superstructure and blocks, locally forming boulder trains, and the progressive reduction of tors to stumps and basal slabs represent the more advanced stages of modification. Recognition of some slabs as tor stumps from which glacial erosion has removed all superstructure allows the original distribution of tors to be reconstructed for large areas of the Cairngorms. Unmodified tors require covers of non-erosive, cold-based ice during all of the cold stages of the Middle and Late Pleistocene. Deformation beneath cold-based glacier ice is capable of the removal of blocks but advanced glacial modification requires former wet-based glacier ice. The depth of glacial erosion at former tor sites remains limited largely to the partial or total elimination of the upstanding tor form. Cosmogenic nuclide exposure ages (Phillips et al., 2006) together with data from weathering pit depths (Hall and Phillips, 2006), from the surfaces of tors and large erratic blocks require that the glacial entrainment of blocks from tors occurred in Marine Isotope Stages (MIS) 4-2, 6 and, probably, at least one earlier phase. The occurrence of glacially modified tors on or close to, the main summits of the Cairngorms requires full ice cover over the mountains during these Stages. Evidence from the Cairngorms indicates that tor morphology can be regarded as an important indicator of former ice cover in many formerly glaciated areas, particularly where other evidence of ice cover is sparse. Recognition of the glacial modification of tors is important

  2. mTOR Signaling Confers Resistance to Targeted Cancer Drugs.

    Guri, Yakir; Hall, Michael N

    2016-11-01

    Cancer is a complex disease and a leading cause of death worldwide. Extensive research over decades has led to the development of therapies that target cancer-specific signaling pathways. However, the clinical benefits of such drugs are at best transient due to tumors displaying intrinsic or adaptive resistance. The underlying compensatory pathways that allow cancer cells to circumvent a drug blockade are poorly understood. We review here recent studies suggesting that mammalian TOR (mTOR) signaling is a major compensatory pathway conferring resistance to many cancer drugs. mTOR-mediated resistance can be cell-autonomous or non-cell-autonomous. These findings suggest that mTOR signaling should be monitored routinely in tumors and that an mTOR inhibitor should be considered as a co-therapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Potyviruses differ in their requirement for TOR signalling.

    Ouibrahim, Laurence; Rubio, Ana Giner; Moretti, André; Montané, Marie-Hélène; Menand, Benoît; Meyer, Christian; Robaglia, Christophe; Caranta, Carole

    2015-09-01

    Potyviruses are important plant pathogens that rely on many plant cellular processes for successful infection. TOR (target of rapamycin) signalling is a key eukaryotic energy-signalling pathway controlling many cellular processes such as translation and autophagy. The dependence of potyviruses on active TOR signalling was examined. Arabidopsis lines downregulated for TOR by RNAi were challenged with the potyviruses watermelon mosaic virus (WMV) and turnip mosaic virus (TuMV). WMV accumulation was found to be severely altered while TuMV accumulation was only slightly delayed. In another approach, using AZD-8055, an active site inhibitor of the TOR kinase, WMV infection was found to be strongly affected. Moreover, AZD-8055 application can cure WMV infection. In contrast, TuMV infection was not affected by AZD-8055. This suggests that potyviruses have different cellular requirements for active plant TOR signalling.

  4. Novel links in the plant TOR kinase signaling network.

    Xiong, Yan; Sheen, Jen

    2015-12-01

    Nutrient and energy sensing and signaling mechanisms constitute the most ancient and fundamental regulatory networks to control growth and development in all life forms. The target of rapamycin (TOR) protein kinase is modulated by diverse nutrient, energy, hormone and stress inputs and plays a central role in regulating cell proliferation, growth, metabolism and stress responses from yeasts to plants and animals. Recent chemical, genetic, genomic and metabolomic analyses have enabled significant progress toward molecular understanding of the TOR signaling network in multicellular plants. This review discusses the applications of new chemical tools to probe plant TOR functions and highlights recent findings and predictions on TOR-mediate biological processes. Special focus is placed on novel and evolutionarily conserved TOR kinase effectors as positive and negative signaling regulators that control transcription, translation and metabolism to support cell proliferation, growth and maintenance from embryogenesis to senescence in the plant system. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Use of Tor (The Onion Router) disallowed from within CERN

    IT Department

    2008-01-01

    Tor is a freely available system enabling anonymous communication via the Internet between its users. Traffic is encrypted in multiple layers and flows through proxy servers . The use of Tor and similar anonymity systems may interfere with CERN’s security monitoring systems and increases the exposure of the CERN network to malicious or illegal material distributed via so-called "Tor Hidden Services". In addition, Tor has been used to mount attacks, including against CERN computers, and its installation could indicate a break-in. For the above reasons Tor and any similar systems will be added to the list of applications whose use is restricted at CERN and anyone who has used such an application is instructed to no longer do so. If a legitimate professional use can be justified then the Computer Security team should be informed and a prior security check made before installation of the software. CERN IT Department

  6. Project management at Heysham II and Torness

    Taylor, D.

    1987-01-01

    The National Nuclear Corporation (NNC) have contracts from the Central Electricity Generating Board (CEGB) and the South of Scotland Electricity Board (SSEB) for the design and construction of the AGR Nuclear Power Stations at Heysham II and Torness. Within these contracts, procurement and construction of the various components making up the Nuclear Island are managed by NNC as agents of the two generating boards. Other responsibilities are for the design of the whole station, preparation of the safety case and on-site management of the Nuclear Island at both stations. Additional responsibilities are included in the Torness contract such that NNC manage almost the whole of the site works. Construction of both stations started in August 1980 and power raising is expected to commence on time at the end of this year. Both stations are close to the original budget. This paper examines factors which have contributed to this success including the relationship between NNC, the contractors, clients and the safety authority. (author)

  7. Main results from NILU`s participation in the TOR project; Hovedresultater fra NILUs deltakelse i TOR-prosjektet

    Solberg, S; Stordahl, F

    1996-01-01

    The conference paper presents the main results from the Norwegian participation in the TOR (Tropospheric Ozone Research) project. The project was a part of the EUROTRAC environment programme which terminated in 1995. The aim of the TOR project was to increase the knowledge on physical and chemical processes being important for the consentration of ozone in the troposphere. 2 refs., 3 figs.

  8. Formation process of Malaysian modern architecture under influence of nationalism

    宇高, 雄志; 山崎, 大智

    2001-01-01

    This paper examines the Formation Process of Malaysian Modern Architecture under Influence of Nationalism,through the process of independence of Malaysia. The national style as "Malaysian national architecture" which hasengaged on background of political environment under the post colonial situation. Malaysian urban design is alsodetermined under the balance of both of ethnic culture and the national culture. In Malaysia, they decided to choosethe Malay ethnic culture as the national culture....

  9. FACTORS INFLUENCING YIELD SPREADS OF THE MALAYSIAN BONDS

    Norliza Ahmad; Joriah Muhammad; Tajul Ariffin Masron

    2009-01-01

    Malaysian bond market is developing rapidly but not much is understood in terms of macroeconomic factors that could influence the yield spread of the Ringgit Malaysian denominated bonds. Based on a multifactor model, this paper examines the impact of four macroeconomic factors namely: Kuala Lumpur Composite Index (KLCI), Industry Production Index (IPI), Consumer Price Index (CPI) and interest rates (IR) on bond yield spread of the Malaysian Government Securities (MGS) and Corporate Bonds (CBs...

  10. Ecografia na patologia torácica

    António Bugalho

    2010-07-01

    Full Text Available Resumo: Nos últimos anos a ecografia torácica tem vindo a ser reconhecida como um instrumento de extrema importância para os pneumologistas. Actualmente, os equipamentos são práticos, portáteis, de fácil utilização e fidedignos, o que os torna apropriados para utilização no diagnóstico e orientação de procedimentos terapêuticos.Na avaliação de derrame pleural e condução de toracentese são necessárias competências técnicas básicas em ultra-sonografia. Procedimentos mais complexos devem ser realizados perante treino específico e incluem a colocação de dreno torácico e identificação com eventual biopsia de lesões torácicas.Os autores procuram abordar, de um ponto de vista prático, a técnica e os recentes avanços alcançados neste campo. São apresentados alguns casos clínicos no sentido de ilustrar e guiar aqueles que desejam iniciar a realização de ecografia do tórax.Rev Port Pneumol 2010; XVI (4: 589-606 Abstract: In the past few years transthoracic ultrasound has been recognized as an important tool for chest physicians. At present, ultrasound devices are practical, portable, easy to use and reliable, which makes them suited for diagnostic investigations as well as for therapeutic procedures guidance.Basic ultrasound technical expertise is required to assess pleural effusions and perform ultrasound-guided thoracentesis. More complex procedures can be done with specific training and include assistance to chest drain insertion and identification with potential biopsy of thoracic lesions.The authors aim to review, in a practical approach, the technique and recent developments in this field. Clinical cases are presented in order to illustrate and guide the beginner in chest ultrasound.Rev Port Pneumol 2010; XVI (4: 589-606 Palavras-chave: Ecografia, ultra-sonografia, tórax, pleura, doenças pulmonares, derrame pleural, cancro do pulmão, Key-words: Ultrasound, sonography, chest, thorax, pleura, lung diseases

  11. Ecografia na patologia torácica

    António Bugalho

    2010-07-01

    Full Text Available Resumo: Nos últimos anos a ecografia torácica tem vindo a ser reconhecida como um instrumento de extrema importância para os pneumologistas. Actualmente, os equipamentos são práticos, portáteis, de fácil utilização e fidedignos, o que os torna apropriados para utilização no diagnóstico e orientação de procedimentos terapêuticos.Na avaliação de derrame pleural e condução de toracentese são necessárias competências técnicas básicas em ultra-sonografia. Procedimentos mais complexos devem ser realizados perante treino específico e incluem a colocação de dreno torácico e identificação com eventual biopsia de lesões torácicas.Os autores procuram abordar, de um ponto de vista prático, a técnica e os recentes avanços alcançados neste campo. São apresentados alguns casos clínicos no sentido de ilustrar e guiar aqueles que desejam iniciar a realização de ecografia do tórax. Abstract: In the past few years transthoracic ultrasound has been recognized as an important tool for chest physicians. At present, ultrasound devices are practical, portable, easy to use and reliable, which makes them suited for diagnostic investigations as well as for therapeutic procedures guidance.Basic ultrasound technical expertise is required to assess pleural effusions and perform ultrasound-guided thoracentesis. More complex procedures can be done with specific training and include assistance to chest drain insertion and identification with potential biopsy of thoracic lesions.The authors aim to review, in a practical approach, the technique and recent developments in this field. Clinical cases are presented in order to illustrate and guide the beginner in chest ultrasound. Palavras-chave: Ecografia, ultra-sonografia, tórax, pleura, doenças pulmonares, derrame pleural, cancro do pulmão, Key-words: Ultrasound, sonography, chest, thorax, pleura, lung diseases, pleural effusion, lung cancer

  12. Data-plane Defenses against Routing Attacks on Tor

    Tan Henry

    2016-10-01

    Full Text Available Tor is susceptible to traffic correlation attacks in which an adversary who observes flows entering and leaving the anonymity network can apply statistical techniques to correlate flows and de-anonymize their endpoints. While an adversary may not be naturally positioned to conduct such attacks, a recent study shows that the Internet’s control-plane can be manipulated to increase an adversary’s view of the network, and consequently, improve its ability to perform traffic correlation. This paper explores, in-depth, the effects of control-plane attacks on the security of the Tor network. Using accurate models of the live Tor network, we quantify Tor’s susceptibility to these attacks by measuring the fraction of the Tor network that is vulnerable and the advantage to the adversary of performing the attacks. We further propose defense mechanisms that protect Tor users from manipulations at the control-plane. Perhaps surprisingly, we show that by leveraging existing trust anchors in Tor, defenses deployed only in the data-plane are sufficient to detect most control-plane attacks. Our defenses do not assume the active participation of Internet Service Providers, and require only very small changes to Tor. We show that our defenses result in a more than tenfold decrease in the effectiveness of certain control-plane attacks.

  13. Radiological emergency: Malaysian preparedness and response

    Yusof, M. A. W.; Ali, H. M.

    2011-01-01

    Planning and preparation in advance for radiological emergencies can help to minimise potential public health and environmental threats if and when an actual emergency occurs. During the planning process, emergency response organisations think through how they would respond to each type of incident and the resources that will be needed. In Malaysia, planning, preparation for and response to radiological emergencies involve many parties. In the event of a radiological emergency and if it is considered a disaster, the National Security Council, the Atomic Energy Licensing Board and the Malaysian Nuclear Agency (Nuclear Malaysia) will work together with other federal agencies, state and local governments, first responders and international organisations to monitor the situation, contain the release, and clean up the contaminated site. Throughout the response, these agencies use their protective action guidelines. This paper discusses Malaysian preparedness for, and response to, any potential radiological emergency. (authors)

  14. Lysophosphatidic acid acyltransferase beta regulates mTOR signaling.

    Michelle A Blaskovich

    Full Text Available Lysophosphatidic acid acyltransferase (LPAAT-β is a phosphatidic acid (PA generating enzyme that plays an essential role in triglyceride synthesis. However, LPAAT-β is now being studied as an important regulator of cell growth and differentiation and as a potential therapeutic target in cancer since PA is necessary for the activity of key proteins such as Raf, PKC-ζ and mTOR. In this report we determine the effect of LPAAT-β silencing with siRNA in pancreatic adenocarcinoma cell lines. We show for the first time that LPAAT-β knockdown inhibits proliferation and anchorage-independent growth of pancreatic cancer cells. This is associated with inhibition of signaling by mTOR as determined by levels of mTORC1- and mTORC2-specific phosphorylation sites on 4E-BP1, S6K and Akt. Since PA regulates the activity of mTOR by modulating its binding to FKBP38, we explored the possibility that LPAAT-β might regulate mTOR by affecting its association with FKBP38. Coimmunoprecipitation studies of FKBP38 with mTOR show increased levels of FKBP38 associated with mTOR when LPAAT-β protein levels are knocked down. Furthermore, depletion of LPAAT-β results in increased Lipin 1 nuclear localization which is associated with increased nuclear eccentricity, a nuclear shape change that is dependent on mTOR, further confirming the ability of LPAAT-β to regulate mTOR function. Our results provide support for the hypothesis that PA generated by LPAAT-β regulates mTOR signaling. We discuss the implications of these findings for using LPAAT-β as a therapeutic target.

  15. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis

    Thedieck, Kathrin; Polak, Pazit; Kim, Man Lyang; Molle, Klaus D; Cohen, Adiel; Jenö, Paul; Arrieumerlou, Cécile; Hall, Michael N

    2007-01-01

    TOR (Target of Rapamycin) is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two functionally and structurally distinct multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2). In the present study, we developed a two-dimensional

  16. Drivers for Malaysian SMEs to Go Green

    M. Krishna Moorthy; Peter a/l Yacob; Mahendra Kumar a/l Chelliah; Lawrence Arokiasamy

    2012-01-01

    Small and Medium Enterprises (SMEs) around the world have little knowledge about environmental management and do not understand the concept of environmental management. The concept of green is still very new to Malaysian SME owners/managers, although many green conferences, seminars and campaigns have been carried out for quite some time. The concept for green process and products in Malaysia is at the infancy stage. The drivers of environmental behavior in SMEs are relatively under-researche...

  17. Transcultural Diabetes Nutrition Algorithm: A Malaysian Application

    Hussein, Zanariah; Hamdy, Osama; Chin Chia, Yook; Lin Lim, Shueh; Kumari Natkunam, Santha; Hussain, Husni; Yeong Tan, Ming; Sulaiman, Ridzoni; Nisak, Barakatun; Chee, Winnie Siew Swee; Marchetti, Albert; Hegazi, Refaat A.; Mechanick, Jeffrey I.

    2013-01-01

    Glycemic control among patients with prediabetes and type 2 diabetes mellitus (T2D) in Malaysia is suboptimal, especially after the continuous worsening over the past decade. Improved glycemic control may be achieved through a comprehensive management strategy that includes medical nutrition therapy (MNT). Evidence-based recommendations for diabetes-specific therapeutic diets are available internationally. However, Asian patients with T2D, including Malaysians, have unique disease characteris...

  18. Malaysian Economic Development: Looking Backwards and Forward

    Hal Hill

    2010-01-01

    This paper provides an analytical and forward-looking overview of Malaysian economic development. Looking back over its 53 years of Independence, we identify the key stylized facts to include the country's generally rapid economic growth and structural change; its consistent openness, especially for merchandize trade and foreign direct investment; its creditable record of macroeconomic management; its consistently high inequality, in spite of the developing world's most consistently implement...

  19. Religiosity, Ethical Judgments and Malaysian Muslim Students

    Rusnah Muhamad

    2014-01-01

    Culture is often cited as one of the powerful determinants in shaping the personality and behaviour of individuals. Religion, being an important element of culture, is seen as playing an important role in determining how people behave in certain situations. Various authors have suggested religion as an important dimension in Malaysian ethical behaviour studies especially for the Malays. Yet this construct is generally ignored or incorporated into other constructs. This study investigates the ...

  20. Internationalisation of the Malaysian Wooden Furniture Industry

    Zhao, LiXu

    2016-01-01

    Malaysia has a strong market share in wooden furniture and the witnessed fast growth made it a leading furniture exporter. Currently, Malaysia is the 8th largest furniture export country. As an export dominated industry, the wooden furniture industry occupies a significant position in the Malaysian economic development. Since the industry is a challenged and deteriorating in global competition, the research objective is to evaluate the present situation and find out strategies on how to impro...

  1. Obituary: Tor Hagfors, 1930-2007

    Aksnes, Kaare

    2007-12-01

    Tor Hagfors, a world leader in the use of radar techniques to observe ionospheres, surfaces and interiors of planetary bodies, died of heart-failure on 17 January 2007, in Puerto Rico, at the age of 76. He was born on 8 December 1930, in Oslo, Norway, and received his education there and in Trondheim, where he graduated with exceptionally good grades with a degree in technical physics from the Norwegian Institute of Technology (NTH) in 1955. Hagfors was then until 1963 employed at the Norwegian Defence Research Establishment (NDRE) where he worked mainly on scattering of high-frequency radio waves in the Earth's ionosphere. This work earned him a PhD in physics from the University of Oslo in 1959. With leave of absence from NDRE, he worked as a Research Associate at Stanford University in 1959/1960, developing a fundamental theory on incoherent scattering of radio waves from electrons in the ionosphere and also participating in radar studies of the Moon's surface in preparation for the later lunar landings. Back in Norway Hagfors continued his scattering studies but, finding that the opportunities for experimental work were limited there, he accepted in 1963 a position at the Massachusetts Institute of Technology's Lincoln Laboratory where he stayed until 1971, interrupted by two years as Director of the Jicamarca Radio Observatory near Lima in Peru 1967-1969. There he gained a reputation as a very inspiring and efficient leader who handled difficult negotiations with the Peruvian military junta very well. In 1971 Hagfors was appointed Director of Operations of the Arecibo Radio Observatory in Puerto Rico, a position that he held and executed in an excellent way until 1973. Although Tor had by now become a United States citizen with a brilliant scientific career, he chose to return to his alma mater, NTH, in Trondheim, where he worked as a Professor of Electronics between 1973 and 1982. From 1975 to 1982 he also served as Director of the European Incoherent Scatter

  2. Electrolyte profile of Malaysian mothers' milk.

    Alaudeen, S; Muslim, N; Faridah, K; Azman, A; Arshat, H

    1988-12-01

    The influence of socioeconomic status (ethnicity, income and parity) on electrolyte composition (sodium and potassium) in human milk is little known. We have thus quantitatively analyzed approximately 700 samples of milk (1-90 days postpartum) obtained from healthy Malaysian mothers' (Malay, Chinese and Indians) of full term infants. Results show that the mean concentration (mmol/l) of sodium is highest (48.2+or-1.7, Mean+or-SEM) in the Malaysian mothers' colostrum and this value decreased by 30% in their transitional milk and remained constant throughout subsequent days of lactation (mature milk). Ethnically, it is found that the level of sodium in colostrum of Malay and Chinese mothers were similar while the Indian mothers' colostrum showed apparently higher value (52.7+or-3.4 mmol/l) that is statistically insignificant. The transitional milk of all 3 ethnic groups studied exhibited similar levels of sodium. On subsequent days of lactation (mature milk) the Malay mothers exhibited lowest concentration (25.9+or-2.6 mmol/l) of sodium that is significantly (P0.05) different from that of Chinese and Indian mothers. Income and parity do not significantly affect the sodium level in Malaysian mothers' milk during all stages of lactation studied. The level of potassium, however did not change significantly with days of lactation. Like sodium, potassium too was not influenced by income and parity. (Author's).

  3. Are Malaysian Children Achieving Dietary Guideline Recommendations?

    Koo, Hui Chin; Poh, Bee Koon; Lee, Shoo Thien; Chong, Kar Hau; Bragt, Marjolijn C E; Abd Talib, Ruzita

    2016-07-01

    A large body of epidemiological data has demonstrated that diet quality follows a sociodemographic gradient. Little is known, however, about food group intake patterns among Malaysian children. This study aimed to assess consumption pattern of 7 food groups, including cereals/grains, legumes, fruits, vegetables, fish, meat/poultry, and milk/dairy products, among children 7 to 12 years of age. A total of 1773 children who participated in SEANUTS Malaysia and who completed the Food Frequency Questionnaire were included in this study. A greater proportion of children aged 10 to 12 years have an inadequate intake of cereals/grains, meat/poultry, legumes, and milk/dairy products compared with children 7 to 9 years old. With the exception of meat/poultry, food consumption of Malaysian children did not meet Malaysian Dietary Guidelines recommendations for the other 6 food groups, irrespective of sociodemographic backgrounds. Efforts are needed to promote healthy and balanced dietary habits, particularly for foods that fall short of recommended intake level. © 2016 APJPH.

  4. Factors Affecting Hypertension among the Malaysian Elderly

    Sima Ataollahi Eshkoor

    2016-03-01

    Full Text Available Hypertension is a common chronic disease in the elderly. This study aimed to determine the effects of age, ethnicity, gender, education, marital status, nutritional parameters, and blood elements on the risk of high blood pressure in the Malaysian elderly. This research was conducted on a group of 2322 non-institutionalized Malaysian elderly. The hierarchy binary logistic regression analysis was applied to estimate the risk of hypertension in respondents. Approximately, 45.61% of subjects had hypertension. The findings indicated that the female gender (Odds ratio (OR = 1.54, an increase in body weight (OR = 1.61, and an increase in the blood levels of albumin (OR = 1.51, glucose (OR = 1.92, and triglycerides (OR = 1.27 significantly increased the risk of hypertension in subjects (p < 0.05. Conversely, an increase in both dietary carbohydrates (OR = 0.74, and blood cholesterol level (OR = 0.42 significantly reduced the risk of hypertension in samples (p < 0.05. Furthermore, the results showed that ethnicity was a non-relevant factor to increase the risk of hypertension in subjects. It was concluded that female gender, an increase in body weight, and an increase in the blood levels of glucose, triglycerides, and albumin enhanced the risk of high blood pressure in the Malaysian elderly. In addition, an increase in both dietary carbohydrates and blood cholesterol level decreased hypertension in subjects.

  5. LAUGHING AT OURSELVES: REFLECTING MALAYSIAN ETHNIC DISPARITIES

    SWAGATA SINHA ROY

    2014-05-01

    Full Text Available Malaysia’s various ethnic groups make interesting study both sociologically and culturally. With such a heady mix of cultural elements to explore, it is often natural that the many groups stumble upon ‘rare gems’ that reflect their ‘Malaysianess’. Have Malaysians really ever appreciated the many and varied aspects of culture that they are seemingly suddenly thrown into? Do we embrace these happily or are we constantly rejecting them? Fortunately, through the medium of film, we are, from time to time, allowed to reflect on our obvious similarities and even more apparent disparities. In this paper, we explore the culture and perceptions of people from the major ethnic groups that are the human base of this very country. When was it we have last laughed at ourselves … heartily? Nasi Lemak 2.0 provides an interesting, if not disturbing insight into the workings of the Malaysian ‘mind’. Nasi Lemak 2.0 was released on 8th September 2011 and impacted a whole generation of Malaysians. The characters have been well chosen and have done a wonderful job of being representations of the various communities in this nation. Ethnocentrism is a reality and often rears its head, ‘ugly’ or otherwise in several situations. Are we able to grapple with the levels of ethnocentrism that we encounter? These are some of the issues that will trigger much debate and discussion among ourselves and perhaps also reflect our cores.

  6. Towards an Autonomous System Monitor for Mitigating Correlation Attacks in the Tor Network

    Hoang, Nguyen Phong

    2016-01-01

    After carefully considering the scalability problem in Tor and exhaustively evaluating related works on AS-level adversaries, the author proposes ASmoniTor, which is an autonomous system monitor for mitigating correlation attacks in the Tor network. In contrast to prior works, which often released offline packets, including the source code of a modified Tor client and a snapshot of the Internet topology, ASmoniTor is an online system that assists end users with mitigating the threat of AS-lev...

  7. Malaysian English: An Instrumental Analysis of Vowel Contrasts

    Pillai, Stefanie; Don, Zuraidah Mohd.; Knowles, Gerald; Tang, Jennifer

    2010-01-01

    This paper makes an instrumental analysis of English vowel monophthongs produced by 47 female Malaysian speakers. The focus is on the distribution of Malaysian English vowels in the vowel space, and the extent to which there is phonetic contrast between traditionally paired vowels. The results indicate that, like neighbouring varieties of English,…

  8. Young Adult Literature in the Malaysian Secondary School

    Govindarajoo, Mallika V.; Mukundan, Jayakaran

    2013-01-01

    This article presents the results of a study on the experience of the Malaysian secondary school student with Young Adult Literature in the English language classroom. The study aimed to determine the extent to which the Malaysian secondary school student identified with the young adult protagonists and issues in the novels which have been…

  9. National space legislation : future perspectives for Malaysian Space Law

    Saari, Che Zuhaida Binti

    2014-01-01

    This research studies the future perspectives for Malaysian space law. It aims at demonstrating the development of Malaysian outer space activities inclusive of her status with respect to United Nations space conventions and her membership of international and regional space-related organizations.

  10. Self-Access Language Learning for Malaysian University Students

    Tse, Andrew Yau Hau

    2012-01-01

    Just a few Malaysian universities offer self-access language learning activities to students. The objective of this study is to investigate if self-access learning can promote self-directed or autonomous learning in a public Malaysian technical university. Data collection is by means of interviewing the Director, lecturers, and students in a…

  11. Lexical Borrowing from Chinese Languages in Malaysian English

    Imm, Tan Siew

    2009-01-01

    This paper explores how contact between English and Chinese has resulted in the incorporation of Chinese borrowings into the lexicon of Malaysian English (ME). Using a corpus-based approach, this study analyses a comprehensive range of borrowed features extracted from the Malaysian English Newspaper Corpus (MEN Corpus). Based on the contexts of…

  12. Malaysian and American Students' Perceptions of Research Ethics

    Bowman, Laura L.; Anthonysamy, Angela

    2006-01-01

    Differences in perceptions of research ethics between Malaysian and American students were assessed using a questionnaire that measured perceptions of voluntary informed consent for adults and children, assessment of the risk/benefit ratio, issues of deception, and issues of privacy and confidentiality. As predicted, Malaysian students had less…

  13. Language Learning Motivation among Malaysian Pre-University Students

    Muftah, Muneera; Rafik-Galea, Shameem

    2013-01-01

    The study describes and examines Malaysian pre-university students' integrative and instrumental motivation toward learning English language. In this study, 182 non-English major students in one of the Malaysian public universities are selected to fill out a questionnaire reflecting their attitudes and motivation towards learning English. The…

  14. The Quest for Strategic Malaysian Quality National Primary School Leaders

    Ali, Hairuddin Mohd

    2012-01-01

    Purpose: The purpose of this paper is to investigate the nine-point strategic leadership characteristics of Malaysian Quality National Primary School Leaders (QNPSL) and to indicate the implications of these findings for the current educational management and leadership practices in their quest for Malaysian quality education.…

  15. Shelf life assessment of Malaysian Pangasius sutchi during cold ...

    Malaysian Pangasius sutchi concerning the marketing sector from the point of view ... Patin (Pangasius sutchi) is a popular freshwater fish used as food in ... remaining shelf life allows a processor or a retailer to plan the length of time a product can be ... While consumption has increased, the Malaysian fisheries industry.

  16. Analysis of mercury in Malaysian herbal preparations | Ang | Journal ...

    The rhizome of Smilax luzonensis is eaten as an aphrodisiac in the Malaysian community. This study was conducted to analyse the mercury content of 100 pharmaceutical dosage forms of S. luzonensis that were purchased in the Malaysian market, using cold vapour atomic absorption spectrophotometer. Results show that ...

  17. Architecture of human mTOR complex 1.

    Aylett, Christopher H S; Sauer, Evelyn; Imseng, Stefan; Boehringer, Daniel; Hall, Michael N; Ban, Nenad; Maier, Timm

    2016-01-01

    Target of rapamycin (TOR), a conserved protein kinase and central controller of cell growth, functions in two structurally and functionally distinct complexes: TORC1 and TORC2. Dysregulation of mammalian TOR (mTOR) signaling is implicated in pathologies that include diabetes, cancer, and neurodegeneration. We resolved the architecture of human mTORC1 (mTOR with subunits Raptor and mLST8) bound to FK506 binding protein (FKBP)-rapamycin, by combining cryo-electron microscopy at 5.9 angstrom resolution with crystallographic studies of Chaetomium thermophilum Raptor at 4.3 angstrom resolution. The structure explains how FKBP-rapamycin and architectural elements of mTORC1 limit access to the recessed active site. Consistent with a role in substrate recognition and delivery, the conserved amino-terminal domain of Raptor is juxtaposed to the kinase active site. Copyright © 2016, American Association for the Advancement of Science.

  18. mTOR Inhibition and Tuberous Sclerosis Prevention

    J Gordon Millichap

    2013-09-01

    Full Text Available Investigators at Children's Memorial Health Institute, Warsaw, Poland, report monozygotic twin sisters with tuberous sclerosis complex (TSC, one treated with the mTOR inhibitor everolimus since age 4 years.

  19. mTOR Inhibition and Clinical Transplantation: Pancreas and Islet.

    Berney, Thierry; Andres, Axel; Toso, Christian; Majno, Pietro; Squifflet, Jean-Paul

    2018-02-01

    This brief overview discusses the beneficial and deleterious effects of mammalian target of rapamycin (mTOR) inhibitors on β cells, and how sirolimus- and everolimus-based immunosuppression have impacted on practices and outcomes of pancreas and islet transplantation. Sirolimus was the cornerstone of immunosuppressive regimens in islet transplantation at the turn of the millenium, but utilization of mTOR inhibitors has progressively decreased from greater than 80% to less than 50% of islet transplant recipients in more recent years. For whole pancreas transplantation, mTOR inhibitors were used in approximately 20% of patients in the early 2000s, but this dropped over the years to less than 10% currently. This decrease is arguably due to less well-tolerated side effects without the advantage of better outcomes. Nonetheless, mTOR inhibitors remain extremely valuable as second-line immunosuppressants in pancreas and islet transplantation.

  20. Past, Present and Future of Tor Hidden Services

    Müller, Konstantin

    2015-01-01

    Using the Internet reveals the IP addresses of both communication parties to everybody, who is able to observe the communication. Anonymity systems like Tor hide the IP addresses and the communication in such a way that the communication cannot be linked between the two parties. Tor is a low-latency anonymity network designed for interactive applications, which allows its users to stay anonymous while using the Internet, for example for Web browsing, e-mail or instant messaging...

  1. mTOR-Dependent Cell Proliferation in the Brain

    Larisa Ryskalin

    2017-01-01

    Full Text Available The mammalian Target of Rapamycin (mTOR is a molecular complex equipped with kinase activity which controls cell viability being key in the PI3K/PTEN/Akt pathway. mTOR acts by integrating a number of environmental stimuli to regulate cell growth, proliferation, autophagy, and protein synthesis. These effects are based on the modulation of different metabolic pathways. Upregulation of mTOR associates with various pathological conditions, such as obesity, neurodegeneration, and brain tumors. This is the case of high-grade gliomas with a high propensity to proliferation and tissue invasion. Glioblastoma Multiforme (GBM is a WHO grade IV malignant, aggressive, and lethal glioma. To date, a few treatments are available although the outcome of GBM patients remains poor. Experimental and pathological findings suggest that mTOR upregulation plays a major role in determining an aggressive phenotype, thus determining relapse and chemoresistance. Among several activities, mTOR-induced autophagy suppression is key in GBM malignancy. In this article, we discuss recent evidence about mTOR signaling and its role in normal brain development and pathological conditions, with a special emphasis on its role in GBM.

  2. mTOR-Dependent Cell Proliferation in the Brain.

    Ryskalin, Larisa; Lazzeri, Gloria; Flaibani, Marina; Biagioni, Francesca; Gambardella, Stefano; Frati, Alessandro; Fornai, Francesco

    2017-01-01

    The mammalian Target of Rapamycin (mTOR) is a molecular complex equipped with kinase activity which controls cell viability being key in the PI3K/PTEN/Akt pathway. mTOR acts by integrating a number of environmental stimuli to regulate cell growth, proliferation, autophagy, and protein synthesis. These effects are based on the modulation of different metabolic pathways. Upregulation of mTOR associates with various pathological conditions, such as obesity, neurodegeneration, and brain tumors. This is the case of high-grade gliomas with a high propensity to proliferation and tissue invasion. Glioblastoma Multiforme (GBM) is a WHO grade IV malignant, aggressive, and lethal glioma. To date, a few treatments are available although the outcome of GBM patients remains poor. Experimental and pathological findings suggest that mTOR upregulation plays a major role in determining an aggressive phenotype, thus determining relapse and chemoresistance. Among several activities, mTOR-induced autophagy suppression is key in GBM malignancy. In this article, we discuss recent evidence about mTOR signaling and its role in normal brain development and pathological conditions, with a special emphasis on its role in GBM.

  3. Leadership in the Reform of Malaysian Universities: Analysing the Strategic Role of the Malaysian Qualifications Agency

    Bajunid, Ibrahim Ahmad

    2011-01-01

    This paper addresses the contemporary development and reform challenges in tertiary education in Malaysia in both national and global contexts. The critical role exercised by the Malaysian Qualifications Agency in driving strategic change in higher education cultures, both in public and private universities is described and analysed. The paper…

  4. The Malaysian Intermodal Terminal System: The Implication on the Malaysian Maritime Cluster

    Mohamad Rosni Othman

    2016-06-01

    Full Text Available The maritime sector in Malaysia is best known globally due to the Straits of Malacca and being a nation surrounded by sea. Malaysia also has a substantial maritime industry consisting of numerous shipyards, ports and terminal faculties, ship services and a plethora of other companies and institutions with maritime oriented activities and become essential components of the Malaysia's maritime clusters. Issues such as underutilised intermodal terminals, uneven proportions in the freight transport infrastructure and road and seaport congestions prevent Malaysian seaports from achieving their full potential in serving their respective hinterlands. The key factors to improve Malaysian dry port or intermodal terminals are transport network; container planning; competition; location and, externalities. The paper does not only present the critical challenges faced by Malaysian intermodal terminals especially dry ports and the implications for seaport competency but it also provides strategies to utilise the Malaysian freight multimodal system to amplify seaports
tm performance in serving their hinterlands. As such, this may warrant policy makers to devise a comprehensive national master plan for the maritime sector in order for Malaysia to further develop her maritime industry and economies.

  5. On Realistically Attacking Tor with Website Fingerprinting

    Wang Tao

    2016-10-01

    Full Text Available Website fingerprinting allows a local, passive observer monitoring a web-browsing client’s encrypted channel to determine her web activity. Previous attacks have shown that website fingerprinting could be a threat to anonymity networks such as Tor under laboratory conditions. However, there are significant differences between laboratory conditions and realistic conditions. First, in laboratory tests we collect the training data set together with the testing data set, so the training data set is fresh, but an attacker may not be able to maintain a fresh data set. Second, laboratory packet sequences correspond to a single page each, but for realistic packet sequences the split between pages is not obvious. Third, packet sequences may include background noise from other types of web traffic. These differences adversely affect website fingerprinting under realistic conditions. In this paper, we tackle these three problems to bridge the gap between laboratory and realistic conditions for website fingerprinting. We show that we can maintain a fresh training set with minimal resources. We demonstrate several classification-based techniques that allow us to split full packet sequences effectively into sequences corresponding to a single page each. We describe several new algorithms for tackling background noise. With our techniques, we are able to build the first website fingerprinting system that can operate directly on packet sequences collected in the wild.

  6. Heysham II/Torness AGR steam generator

    Charcharos, A.N.; Wood, M.B.; Glasgow, J.R.

    1988-01-01

    The AGR Steam Generators for Heysham II and Torness Power Stations have been installed at site and are being operated in the initial low temperature commissioning plant engineering tests. In this paper a description of the high pressure once-through steam generators together with layout arrangements, materials employed, operating parameters, plant operating conditions and constraints is given. An outline of the development of the design through thermo-hydraulic considerations, mechanical design, instrumentation to component testing is presented. Special features of the design directed to accommodate such requirements as seismic loadings, waterside static and dynamic stability, gas flow induced vibration, thermal expansions are described in detail. The fabrication facilities employed and techniques selected and developed for the manufacture and assembly of the heating surfaces are presented. These include welding processes, tube manipulation and heat treatment with details of the automation applied to the processes. Operating experience in the early commissioning plant engineering tests at Site is described with an emphasis on those tests which provide the final confirmation of the design prior to operation at full load. The paper concludes with a description of the outstanding commissioning activities up to raise power. (author)

  7. Heysham II/Torness AGR steam generator

    Charcharos, A N [National Nuclear Corporation Ltd., Knutsford (United Kingdom); Wood, M B; Glasgow, J R [NEI Power Projects Ltd., Gateshead (United Kingdom)

    1988-07-01

    The AGR Steam Generators for Heysham II and Torness Power Stations have been installed at site and are being operated in the initial low temperature commissioning plant engineering tests. In this paper a description of the high pressure once-through steam generators together with layout arrangements, materials employed, operating parameters, plant operating conditions and constraints is given. An outline of the development of the design through thermo-hydraulic considerations, mechanical design, instrumentation to component testing is presented. Special features of the design directed to accommodate such requirements as seismic loadings, waterside static and dynamic stability, gas flow induced vibration, thermal expansions are described in detail. The fabrication facilities employed and techniques selected and developed for the manufacture and assembly of the heating surfaces are presented. These include welding processes, tube manipulation and heat treatment with details of the automation applied to the processes. Operating experience in the early commissioning plant engineering tests at Site is described with an emphasis on those tests which provide the final confirmation of the design prior to operation at full load. The paper concludes with a description of the outstanding commissioning activities up to raise power. (author)

  8. Malaysian Nuclear Agency: Annual report 2008

    2008-01-01

    The establishment of Malaysian Nuclear Agency (Nuclear Malaysia) was mooted from idea of the then Malaysia's Deputy Prime Minister, Tun Dr. Ismail Dato Abdul Rahman, that Malaysia should play a role in the development of nuclear science and technology for peaceful purposes. The Centre for Application of Nuclear Energy (CRANE) was the entity to mark the of Malaysia's nuclear programme, focussing on manpower development for a nuclear power programme to provide an option for energy source, following the worldwide oil crisis of the early 1970s. The Cabinet officially approved the establishment of the Tun Ismail Atomic Research Centre (PUSPATI), under the Ministry of Science, Technology and the environment on 19 September 1972. The era of nuclear research in Malaysia began with the historic event signified by the Reaktor TRIGA PUSPATI reaching its first criticality on 28 June 1982. When PUSPATI was placed under the auspices of the Prime Ministers Department, it assumed the name Nuclear Energy Unit (UTN). The Nuclear Energy Unit was later placed under the Minister of Science, Technology and the Environment. In line with the national development, the institute was name Malaysian Institute for Nuclear Technology Research (MINT) on 10 August 1994. To reflect its vision, mission, objectives and activities in the challenging world, a new identity was established, and was officially named as Malaysian Nuclear Agency (Nuclear Malaysia) on 28 September 2006. Nuclear Malaysia, is strategically located nearby the government administration, centre Putrajaya, and Cyberjaya. These annual report highlights all the activities that have been through by the agency in 2008. All the achievements and triumph were highlights in this annual report. It also contained all the agency planning during 2008 to fulfill the objectives, mission and vision to become main players in nuclear research in Malaysia. Finally, there also highlights some publications contribute by all the researchers from

  9. Malaysian Nuclear Agency: Annual report 2009

    2009-01-01

    The establishment of Malaysian Nuclear Agency (Nuclear Malaysia) was mooted from idea of the then Malaysia's Deputy Prime Minister, Tun Dr. Ismail Dato Abdul Rahman, that Malaysia should play a role in the development of nuclear science and technology for peaceful purposes. The Centre for Application of Nuclear Energy (CRANE) was the entity to mark the of Malaysia's nuclear programme, focussing on manpower development for a nuclear power programme to provide an option for energy source, following the worldwide oil crisis of the early 1970s. The Cabinet officially approved the establishment of the Tun Ismail Atomic Research Centre (PUSPATI), under the Ministry of Science, Technology and the environment on 19 September 1972. The era of nuclear research in Malaysia began with the historic event signified by the Reaktor TRIGA PUSPATI reaching its first criticality on 28 June 1982. When PUSPATI was placed under the auspices of the Prime Ministers Department, it assumed the name Nuclear Energy Unit (UTN). The Nuclear Energy Unit was later placed under the Minister of Science, Technology and the Environment. In line with the national development, the institute was name Malaysian Institute for Nuclear Technology Research (MINT) on 10 August 1994. To reflect its vision, mission, objectives and activities in the challenging world, a new identity was established, and was officially named as Malaysian Nuclear Agency (Nuclear Malaysia) on 28 September 2006. Nuclear Malaysia, is strategically located nearby the government administration, centre Putrajaya, and Cyberjaya. These annual report highlights all the activities that have been through by the agency in 2009. All the achievements and triumph were highlights in this annual report. It also contained all the agency planning during 2009 to fulfill the objectives, mission and vision to become main players in nuclear research in Malaysia. Finally, there also highlights some publications contribute by all the researchers from

  10. Malaysian Nuclear Agency; Annual report 2013

    2013-01-01

    The establishment of Malaysian Nuclear Agency (Nuclear Malaysia) was mooted from idea of the then Malaysia's Deputy Prime Minister, Tun Dr. Ismail Dato Abdul Rahman, that Malaysia should play a role in the development of nuclear science and technology for peaceful purposes. The Centre for Application of Nuclear Energy (CRANE) was the entity to mark the of Malaysia's nuclear programme, focussing on manpower development for a nuclear power programme to provide an option for energy source, following the worldwide oil crisis of the early 1970s. The Cabinet officially approved the establishment of the Tun Ismail Atomic Research Centre (PUSPATI), under the Ministry of Science, Technology and the environment on 19 September 1972. The era of nuclear research in Malaysia began with the historic event signified by the Reaktor TRIGA PUSPATI reaching its first criticality on 28 June 1982. When PUSPATI was placed under the auspices of the Prime Ministers Department, it assumed the name Nuclear Energy Unit (UTN). The Nuclear Energy Unit was later placed under the Minister of Science, Technology and the Environment. In line with the national development, the institute was name Malaysian Institute for Nuclear Technology Research (MINT) on 10 August 1994. To reflect its vision, mission, objectives and activities in the challenging world, a new identity was established, and was officially named as Malaysian Nuclear Agency (Nuclear Malaysia) on 28 September 2006. Nuclear Malaysia, is strategically located nearby the government administration, centre Putrajaya, and Cyberjaya. These annual report highlights all the activities that have been through by the agency in 2013. All the achievements and triumph were highlights in this annual report. It also contained all the agency planning during 2013 to fulfill the objectives, mission and vision to become main players in nuclear research in Malaysia. Finally, there also highlights some publications contribute by all the researchers

  11. Malaysian Nuclear Agency: Annual report 2010

    2010-01-01

    The establishment of Malaysian Nuclear Agency (Nuclear Malaysia) was mooted from idea of the then Malaysia's Deputy Prime Minister, Tun Dr. Ismail Dato Abdul Rahman, that Malaysia should play a role in the development of nuclear science and technology for peaceful purposes. The Centre for Application of Nuclear Energy (CRANE) was the entity to mark the of Malaysia's nuclear programme, focussing on manpower development for a nuclear power programme to provide an option for energy source, following the worldwide oil crisis of the early 1970s. The Cabinet officially approved the establishment of the Tun Ismail Atomic Research Centre (PUSPATI), under the Ministry of Science, Technology and the environment on 19 September 1972. The era of nuclear research in Malaysia began with the historic event signified by the Reaktor TRIGA PUSPATI reaching its first criticality on 28 June 1982. When PUSPATI was placed under the auspices of the Prime Ministers Department, it assumed the name Nuclear Energy Unit (UTN). The Nuclear Energy Unit was later placed under the Minister of Science, Technology and the Environment. In line with the national development, the institute was name Malaysian Institute for Nuclear Technology Research (MINT) on 10 August 1994. To reflect its vision, mission, objectives and activities in the challenging world, a new identity was established, and was officially named as Malaysian Nuclear Agency (Nuclear Malaysia) on 28 September 2006. Nuclear Malaysia, is strategically located nearby the government administration, centre Putrajaya, and Cyberjaya. These annual report highlights all the activities that have been through by the agency in 2010. All the achievements and triumph were highlights in this annual report. It also contained all the agency planning during 2010 to fulfill the objectives, mission and vision to become main players in nuclear research in Malaysia. Finally, there also highlights some publications contribute by all the researchers from

  12. Malaysian Nuclear Agency; Annual report 2014

    2009-01-01

    The establishment of Malaysian Nuclear Agency (Nuclear Malaysia) was mooted from idea of the then Malaysia's Deputy Prime Minister, Tun Dr. Ismail Dato Abdul Rahman, that Malaysia should play a role in the development of nuclear science and technology for peaceful purposes. The Centre for Application of Nuclear Energy (CRANE) was the entity to mark the of Malaysia's nuclear programme, focussing on manpower development for a nuclear power programme to provide an option for energy source, following the worldwide oil crisis of the early 1970s. The Cabinet officially approved the establishment of the Tun Ismail Atomic Research Centre (PUSPATI), under the Ministry of Science, Technology and the environment on 19 September 1972. The era of nuclear research in Malaysia began with the historic event signified by the Reaktor TRIGA PUSPATI reaching its first criticality on 28 June 1982. When PUSPATI was placed under the auspices of the Prime Ministers Department, it assumed the name Nuclear Energy Unit (UTN). The Nuclear Energy Unit was later placed under the Minister of Science, Technology and the Environment. In line with the national development, the institute was name Malaysian Institute for Nuclear Technology Research (MINT) on 10 August 1994. To reflect its vision, mission, objectives and activities in the challenging world, a new identity was established, and was officially named as Malaysian Nuclear Agency (Nuclear Malaysia) on 28 September 2006. Nuclear Malaysia, is strategically located nearby the government administration, centre Putrajaya, and Cyberjaya. These annual report highlights all the activities that have been through by the agency in 2014. All the achievements and triumph were highlights in this annual report. It also contained all the agency planning during 2014 to fulfill the objectives, mission and vision to become main players in nuclear research in Malaysia. Finally, there also highlights some publications contribute by all the researchers

  13. Malaysian Nuclear Agency; Annual report 2011

    2008-01-01

    The establishment of Malaysian Nuclear Agency (Nuclear Malaysia) was mooted from idea of the then Malaysia's Deputy Prime Minister, Tun Dr. Ismail Dato Abdul Rahman, that Malaysia should play a role in the development of nuclear science and technology for peaceful purposes. The Centre for Application of Nuclear Energy (CRANE) was the entity to mark the of Malaysia's nuclear programme, focussing on manpower development for a nuclear power programme to provide an option for energy source, following the worldwide oil crisis of the early 1970s. The Cabinet officially approved the establishment of the Tun Ismail Atomic Research Centre (PUSPATI), under the Ministry of Science, Technology and the environment on 19 September 1972. The era of nuclear research in Malaysia began with the historic event signified by the Reaktor TRIGA PUSPATI reaching its first criticality on 28 June 1982. When PUSPATI was placed under the auspices of the Prime Ministers Department, it assumed the name Nuclear Energy Unit (UTN). The Nuclear Energy Unit was later placed under the Minister of Science, Technology and the Environment. In line with the national development, the institute was name Malaysian Institute for Nuclear Technology Research (MINT) on 10 August 1994. To reflect its vision, mission, objectives and activities in the challenging world, a new identity was established, and was officially named as Malaysian Nuclear Agency (Nuclear Malaysia) on 28 September 2006. Nuclear Malaysia, is strategically located nearby the government administration, centre Putrajaya, and Cyberjaya. These annual report highlights all the activities that have been through by the agency in 2011. All the achievements and triumph were highlights in this annual report. It also contained all the agency planning during 2011 to fulfill the objectives, mission and vision to become main players in nuclear research in Malaysia. Finally, there also highlights some publications contribute by all the researchers from

  14. Repositioning Strategy for Malaysian Companies Internationalization

    Ismi Rajiani

    2013-05-01

    Full Text Available 1024x768 The rise of the emerging-market countries offers both developing and developed countries a unique opportunity to gain the benefits of a truly international economy. Consequently, it is imperative to advance our knowledge of emerging-market countries MNC emergence and competitiveness including Malaysian firms on how will they position their products strategically? Based on the framework of Porter’s Generic Strategy this paper is composed of price/ volume segments and impacts on product strategy theory. The aim is to identify crucial triggering cues and focus areas for Malaysian companies and measure what role these play in different segments. This study argues that some Malaysian companies will reposition themselves strategically when internationalizing and that they will focus on other factors or triggering cues when doing so not merely adapting the prevalent price leadership strategy. Normal 0 false false false IN X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  15. The prognostic role of mTOR and p-mTOR for survival in non-small cell lung cancer: a systematic review and meta-analysis.

    Lei Li

    Full Text Available The mammalian target of rapamycin (mTOR and phosphorylated mTOR (p-mTOR are potential prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC. However, the association between mTOR/p-mTOR expression and NSCLC patients' prognosis remains controversial. Thus, a meta-analysis of existing studies evaluating the prognostic role of mTOR/p-mTOR expression for NSCLC was conducted.A systemically literature search was performed via Pubmed, Embase, Medline as well as CNKI (China National Knowledge Infrastructure. Studies were included that reported the hazard ratio (HR and 95%CI for the association between mTOR/p-mTOR expression and NSCLC patients' survival. Random-effects model was used to pool HRs.Ten eligible studies were included in this meta-analysis, with 4 about m-TOR and 7 about p-mTOR. For mTOR, the pooled HR of overall survival (OS was 1.00 (95%CI 0.5 to 1.99 by univariate analysis and 1.22 (95%CI 0.53 to 2.82 by multivariate analysis. For p-mTOR, the pooled HR was 1.39 (95%CI 0.97 to 1.98 by univariate analysis and 1.42 (95%CI 0.56 to 3.60 by multivariate analysis.The results indicated that no statistically significant association was found between mTOR/p-mTOR expression and NSCLC patients' prognosis.

  16. Mood and Performance in Young Malaysian Karateka

    Wong, Rebecca S. K.; Thung, Jin Seng; Pieter, Willy

    2006-01-01

    In an attempt to test the conceptual model by Lane and Terry, the purposes of this study were 1) to assess mood states in non-depressed and depressed young karate athletes; 2) to assess mood states in relation to performance in young karate athletes. The participants were recruited from the 2004 Malaysian Games (72 males, 19.20 ± 1.16 years; 37 females, 18.78 ± 0.88 years). The athletes were divided into winners (medalists) and losers. The Brunel Mood Scale (BRUMS) was administered prior to t...

  17. Divergence of iron metabolism in wild Malaysian yeast.

    Lee, Hana N; Mostovoy, Yulia; Hsu, Tiffany Y; Chang, Amanda H; Brem, Rachel B

    2013-12-09

    Comparative genomic studies have reported widespread variation in levels of gene expression within and between species. Using these data to infer organism-level trait divergence has proven to be a key challenge in the field. We have used a wild Malaysian population of S. cerevisiae as a test bed in the search to predict and validate trait differences based on observations of regulatory variation. Malaysian yeast, when cultured in standard medium, activated regulatory programs that protect cells from the toxic effects of high iron. Malaysian yeast also showed a hyperactive regulatory response during culture in the presence of excess iron and had a unique growth defect in conditions of high iron. Molecular validation experiments pinpointed the iron metabolism factors AFT1, CCC1, and YAP5 as contributors to these molecular and cellular phenotypes; in genome-scale sequence analyses, a suite of iron toxicity response genes showed evidence for rapid protein evolution in Malaysian yeast. Our findings support a model in which iron metabolism has diverged in Malaysian yeast as a consequence of a change in selective pressure, with Malaysian alleles shifting the dynamic range of iron response to low-iron concentrations and weakening resistance to extreme iron toxicity. By dissecting the iron scarcity specialist behavior of Malaysian yeast, our work highlights the power of expression divergence as a signpost for biologically and evolutionarily relevant variation at the organismal level. Interpreting the phenotypic relevance of gene expression variation is one of the primary challenges of modern genomics.

  18. TOR signaling downregulation increases resistance to the cereal killer Fusarium graminearum.

    Aznar, Néstor R; Consolo, V Fabiana; Salerno, Graciela L; Martínez-Noël, Giselle M A

    2018-02-01

    TOR is the master regulator of growth and development that senses energy availability. Biotic stress perturbs metabolic and energy homeostasis, making TOR a good candidate to participate in the plant response. Fusarium graminearum (Fusarium) produces important losses in many crops all over the world. To date, the role of TOR in Fusarium infection has remained unexplored. Here, we show that the resistance to the pathogen increases in different Arabidopsis mutants impaired in TOR complex or in wild-type plants treated with a TOR inhibitor. We conclude that TOR signaling is involved in plant defense against Fusarium.

  19. Post Fukushima tsunami simulations for Malaysian coasts

    Koh, Hock Lye, E-mail: kohhl@ucsiuniversity.edu.my [Office of Deputy Vice Chancellor for Research and Post Graduate Studies, UCSI University, Jalan Menara Gading, 56000 Kuala Lumpur (Malaysia); Teh, Su Yean, E-mail: syteh@usm.my [School of Mathematical Sciences, Universiti Sains Malaysia, 11800 Pulau Pinang (Malaysia); Abas, Mohd Rosaidi Che [Malaysian Meteorological Department, MOSTI, Kuala Lumpur (Malaysia)

    2014-10-24

    The recent recurrences of mega tsunamis in the Asian region have rekindled concern regarding potential tsunamis that could inflict severe damage to affected coastal facilities and communities. The 11 March 2011 Fukushima tsunami that crippled nuclear power plants in Northern Japan has further raised the level of caution. The recent discovery of petroleum reserves in the coastal water surrounding Malaysia further ignites the concern regarding tsunami hazards to petroleum facilities located along affected coasts. Working in a group, federal government agencies seek to understand the dynamics of tsunami and their impacts under the coordination of the Malaysian National Centre for Tsunami Research, Malaysian Meteorological Department. Knowledge regarding the generation, propagation and runup of tsunami would provide the scientific basis to address safety issues. An in-house tsunami simulation models known as TUNA has been developed by the authors to assess tsunami hazards along affected beaches so that mitigation measures could be put in place. Capacity building on tsunami simulation plays a critical role in the development of tsunami resilience. This paper aims to first provide a simple introduction to tsunami simulation towards the achievement of tsunami simulation capacity building. The paper will also present several scenarios of tsunami dangers along affected Malaysia coastal regions via TUNA simulations to highlight tsunami threats. The choice of tsunami generation parameters reflects the concern following the Fukushima tsunami.

  20. Transcultural diabetes nutrition algorithm: a malaysian application.

    Hussein, Zanariah; Hamdy, Osama; Chin Chia, Yook; Lin Lim, Shueh; Kumari Natkunam, Santha; Hussain, Husni; Yeong Tan, Ming; Sulaiman, Ridzoni; Nisak, Barakatun; Chee, Winnie Siew Swee; Marchetti, Albert; Hegazi, Refaat A; Mechanick, Jeffrey I

    2013-01-01

    Glycemic control among patients with prediabetes and type 2 diabetes mellitus (T2D) in Malaysia is suboptimal, especially after the continuous worsening over the past decade. Improved glycemic control may be achieved through a comprehensive management strategy that includes medical nutrition therapy (MNT). Evidence-based recommendations for diabetes-specific therapeutic diets are available internationally. However, Asian patients with T2D, including Malaysians, have unique disease characteristics and risk factors, as well as cultural and lifestyle dissimilarities, which may render international guidelines and recommendations less applicable and/or difficult to implement. With these thoughts in mind, a transcultural Diabetes Nutrition Algorithm (tDNA) was developed by an international task force of diabetes and nutrition experts through the restructuring of international guidelines for the nutritional management of prediabetes and T2D to account for cultural differences in lifestyle, diet, and genetic factors. The initial evidence-based global tDNA template was designed for simplicity, flexibility, and cultural modification. This paper reports the Malaysian adaptation of the tDNA, which takes into account the epidemiologic, physiologic, cultural, and lifestyle factors unique to Malaysia, as well as the local guidelines recommendations.

  1. Transcultural Diabetes Nutrition Algorithm: A Malaysian Application

    Zanariah Hussein

    2013-01-01

    Full Text Available Glycemic control among patients with prediabetes and type 2 diabetes mellitus (T2D in Malaysia is suboptimal, especially after the continuous worsening over the past decade. Improved glycemic control may be achieved through a comprehensive management strategy that includes medical nutrition therapy (MNT. Evidence-based recommendations for diabetes-specific therapeutic diets are available internationally. However, Asian patients with T2D, including Malaysians, have unique disease characteristics and risk factors, as well as cultural and lifestyle dissimilarities, which may render international guidelines and recommendations less applicable and/or difficult to implement. With these thoughts in mind, a transcultural Diabetes Nutrition Algorithm (tDNA was developed by an international task force of diabetes and nutrition experts through the restructuring of international guidelines for the nutritional management of prediabetes and T2D to account for cultural differences in lifestyle, diet, and genetic factors. The initial evidence-based global tDNA template was designed for simplicity, flexibility, and cultural modification. This paper reports the Malaysian adaptation of the tDNA, which takes into account the epidemiologic, physiologic, cultural, and lifestyle factors unique to Malaysia, as well as the local guidelines recommendations.

  2. Transcultural Diabetes Nutrition Algorithm: A Malaysian Application

    Hamdy, Osama; Chin Chia, Yook; Lin Lim, Shueh; Kumari Natkunam, Santha; Yeong Tan, Ming; Sulaiman, Ridzoni; Nisak, Barakatun; Chee, Winnie Siew Swee; Marchetti, Albert; Hegazi, Refaat A.; Mechanick, Jeffrey I.

    2013-01-01

    Glycemic control among patients with prediabetes and type 2 diabetes mellitus (T2D) in Malaysia is suboptimal, especially after the continuous worsening over the past decade. Improved glycemic control may be achieved through a comprehensive management strategy that includes medical nutrition therapy (MNT). Evidence-based recommendations for diabetes-specific therapeutic diets are available internationally. However, Asian patients with T2D, including Malaysians, have unique disease characteristics and risk factors, as well as cultural and lifestyle dissimilarities, which may render international guidelines and recommendations less applicable and/or difficult to implement. With these thoughts in mind, a transcultural Diabetes Nutrition Algorithm (tDNA) was developed by an international task force of diabetes and nutrition experts through the restructuring of international guidelines for the nutritional management of prediabetes and T2D to account for cultural differences in lifestyle, diet, and genetic factors. The initial evidence-based global tDNA template was designed for simplicity, flexibility, and cultural modification. This paper reports the Malaysian adaptation of the tDNA, which takes into account the epidemiologic, physiologic, cultural, and lifestyle factors unique to Malaysia, as well as the local guidelines recommendations. PMID:24385984

  3. The TOR Complex: An Emergency Switch for Root Behavior.

    Yokawa, Ken; Baluška, František

    2016-01-01

    Target of rapamycin (TOR) kinase is known to be a controller of cell growth and aging, which determines the fine balance between growth rates and energy availabilities. It has been reported that many eukaryotes express TOR genes. In plants, TOR signaling modifies growth and development in response to a plant's energy status. An example of TOR action can be found in the root apices, which are active organs that explore the soil environment via vigorous growth and numerous tropisms. The exploratory nature of root apices requires a large energy supply for signaling, as well as for cell division and elongation. In the case of negative tropisms, roots must respond quickly to avoid patches of unfavorable soil conditions, again by consuming precious energy reserves. Here we review the current findings on TOR signaling in plants and animals, and propose possible roles for this important complex in driving plant root negative tropisms, particularly during light escape and salt avoidance behavior. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  4. [The effects of TorR protein on initiation of DNA replication in Escherichia coli].

    Yuan, Yao; Jiaxin, Qiao; Jing, Li; Hui, Li; Morigen, Morigen

    2015-03-01

    The two-component systems, which could sense and respond to environmental changes, widely exist in bacteria as a signal transduction pathway. The bacterial CckA/CtrA, ArcA/ArcB and PhoP/PhoQ two-component systems are associated with initiation of DNA replication and cell division, however, the effects of the TorS/TorR system on cell cycle and DNA replication remains unknown. The TorS/TorR system in Escherichia coli can sense changes in trimethylamine oxide (TMAO) concentration around the cells. However, it is unknown if it also affects initiation of DNA replication. We detected DNA replication patterns in ΔtorS and ΔtorR mutant strains by flow cytometry. We found that the average number of replication origins (oriCs) per cell and doubling time in ΔtorS mutants were the same while the average number of oriCs in ΔtorR mutants was increased compared with that in wild-type cells. These results indicated that absence of TorR led to an earlier initiation of DNA replication than that in wild-type cells. Strangely, neither overexpression of TorR nor co-expression of TorR and TorS could restore ΔtorR mutant phenotype to the wild type. However, overexpression of SufD in both wild type and ΔtorR mutants promoted initiation of DNA replication, while mutation of SufD delayed it in ΔtorR mutants. Thus, TorR may affect initiation of DNA replication indirectly through regulating gene expression of sufD.

  5. TOR and paradigm change: cell growth is controlled.

    Hall, Michael N

    2016-09-15

    This year marks the 25th anniversary of the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell growth. In this Retrospective, I briefly describe the discovery of TOR and the subsequent elucidation of its cellular role. I place particular emphasis on an article by Barbet et al. from 1996, the first suggesting that TOR controls cell growth in response to nutrients. © 2016 Hall. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  6. Torness and Hunterston - as uneconomic as Sizewell B

    Jeffery, J.W.

    1986-01-01

    The admission by CEGB that Sizewell B would be uneconomic under conditions postulated in the evidence given by the present author at the Sizewell Inquiry, is used to show that Torness and Hunterston AGRs have almost no chance of being economic, because the large immediate increases in postulated real coal prices required to enable Torness to produce a lifetime surplus, have not materialized. The attempt of SSEB to conceal the fact that it postulated this large increase in real coal prices in order to make Torness appear to be economic, is described and exposed. The joint practice of CEGB and SSEB of discounting long-term nuclear costs so that they make no significant contribution to the final calculated unit cost is described. Finally, the recent document, explaining the SSEB's case for keeping the AGR, is analysed and characterized as 'one of the most misleading documents on the economics of nuclear power to be seriously presented to the public'. (author)

  7. TOR Complexes and the Maintenance of Cellular Homeostasis.

    Eltschinger, Sandra; Loewith, Robbie

    2016-02-01

    The Target of Rapamycin (TOR) is a conserved serine/threonine (ser/thr) kinase that functions in two, distinct, multiprotein complexes called TORC1 and TORC2. Each complex regulates different aspects of eukaryote growth: TORC1 regulates cell volume and/or mass by influencing protein synthesis and turnover, while TORC2, as detailed in this review, regulates cell surface area by influencing lipid production and intracellular turgor. TOR complexes function in feedback loops, implying that downstream effectors are also likely to be involved in upstream regulation. In this regard, the notion that TORCs function primarily as mediators of cellular and organismal homeostasis is fundamentally different from the current, predominate view of TOR as a direct transducer of extracellular biotic and abiotic signals. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Remote maintenance in TOR fast reactor fuel reprocessing facility

    Eymery, R.; Constant, M.; Malterre, G.

    1986-11-01

    The TOR facility which is undergoing commissioning tests has a capacity of 5 T. HM/year which is enough for reprocessing all the Phenix fuel, with an excess capacity which is to be used for other fast reactors fuels. It is the result of enlargement and renovation of the old Marcoule pilot facility. A good load factor is expected through the use of equipment with increased reliability and easy maintenance. TOR will also be used to test new equipment developed for the large breeder fuel reprocessing plant presently in the design stage. The latter objective is specifically important for the parts of the plant involving mechanical equipment which are located in a new building: TOR 1. High reliability and flexibility will be obtained in this building thanks to the attention given to the integrated remote handling system [fr

  9. Marketing Malaysian enterprises in Brazil: what is the government ...

    Marketing Malaysian enterprises in Brazil: what is the government doing? ... Marketing products and services abroad is essential for the new ventures growth and continuous existence. ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  10. Emergency Management for Disasters in Malaysian Hotel Industry

    AlBattat Ahmad Rasmi

    2014-01-01

    Full Text Available This paper aims to identify major emergencies that have the potential to place Malaysian hotels in emergency and disaster situations; investigate how hotels were prepared for emergencies, how they manage and overcome emergencies when occurred; and limitations and factors influencing successful emergency planning and adoption emergency management in Malaysian hotels. Face-to-face interview with managers from three, four and five star hotels from different backgrounds: local; regional; and International in Kuala Lumpur, Subang, and Putrajaya are undertaken. The result revealed that Malaysian hotels are exposed to a wide range of natural and man-made disasters. Malaysian hotels lack proactive emergency planning and a lot of constraints which impede successful emergency planning for disasters in the hotel industry in Malaysia, with emphasizing on the relevant authority’s role to demonstrate emergency management to hotels convincing them to adopt such practices, so they can be able to cope with emergencies effectively.

  11. Malaysian sign language dataset for automatic sign language ...

    Journal of Fundamental and Applied Sciences. Journal Home · ABOUT ... SL recognition system based on the Malaysian Sign Language (MSL). Implementation results are described. Keywords: sign language; pattern classification; database.

  12. mTOR inhibitors in urinary bladder cancer.

    Pinto-Leite, R; Arantes-Rodrigues, R; Sousa, Nuno; Oliveira, P A; Santos, L

    2016-09-01

    Despite the great scientific advances that have been made in cancer treatment, there is still much to do, particularly with regard to urinary bladder cancer. Some of the drugs used in urinary bladder cancer treatment have been in use for more than 30 years and show reduced effectiveness and high recurrence rates. There have been several attempts to find new and more effective drugs, to be used alone or in combination with the drugs already in use, in order to overcome this situation.The biologically important mammalian target of rapamycin (mTOR) pathway is altered in cancer and mTOR inhibitors have raised many expectations as potentially important anticancer drugs. In this article, the authors will review the mTOR pathway and present their experiences of the use of some mTOR inhibitors, sirolimus, everolimus and temsirolimus, in isolation and in conjunction with non-mTOR inhibitors cisplatin and gemcitabine, on urinary bladder tumour cell lines. The non-muscle-invasive cell line, 5637, is the only one that exhibits a small alteration in the mTOR and AKT phosphorylation after rapalogs exposure. Also, there was a small inhibition of cell proliferation. With gemcitabine plus everolimus or temsirolimus, the results were encouraging as a more effective response was noticed with both combinations, especially in the 5637 and T24 cell lines. Cisplatin associated with everolimus or temsirolimus also gave promising results, as an antiproliferative effect was observed when the drugs were associated, in particular on the 5637 and HT1376 cell lines. Everolimus or temsirolimus in conjunction with gemcitabine or cisplatin could have an important role to play in urinary bladder cancer treatment, depending on the tumour grading.

  13. Emergency Management for Disasters in Malaysian Hotel Industry

    AlBattat Ahmad Rasmi; Mat Som Ahmad Puad; Abukhalifeh Ala`a

    2014-01-01

    This paper aims to identify major emergencies that have the potential to place Malaysian hotels in emergency and disaster situations; investigate how hotels were prepared for emergencies, how they manage and overcome emergencies when occurred; and limitations and factors influencing successful emergency planning and adoption emergency management in Malaysian hotels. Face-to-face interview with managers from three, four and five star hotels from different backgrounds: local; regional; and Inte...

  14. The Malaysian Public Procurement's Prevalent System and its Weaknesses

    Rohana Othman; Husein Zakaria; Norlaili Nordin; Zamzam Shahidan; Kamaruzaman Jusoff

    2010-01-01

    Problem statement: This study examined the public procurement system as prevalent in the Malaysian government system of administration. Various aspects of public procurement are outlined including types and the processes that entail public procurement. This study also highlighted the weaknesses in the manual public procurement processes that are opened to potential abuse and mismanagement resulting in corruption. This study places the Malaysian Government public procurement system under the s...

  15. Review of inspection of Torness reactor internals using remote techniques

    Dynan, J.

    1993-01-01

    Inspection of reactor internals is increasingly being achieved by deployment of cameras into areas of sometimes high radiation fields using manipulators. The manipulators have been developed over a number of years and from a variety of sources and those provided at Torness can maybe be seen to be the state of the art development of such machines for AGRS. Torness and Heysham 2 reactors were specifically designed for inspection using remote techniques and special facilities have been provided for this purpose. This paper is written by an operator and not a manipulator specialist and is intended to show what the operator needs versus what the designer gave him. (author)

  16. Attenuation of trace organic compounds (TOrCs) inbioelectrochemical systems

    Werner, Craig M.

    2015-04-01

    Microbial fuel cells (MFCs) and microbial electrolysis cells (MECs) are two types of microbial bioelectrochemical systems (BESs) that use microorganisms to convert chemical energy in wastewaters into useful energy products such as (bio)electricity (MFC) or hydrogen gas (MEC). These two systems were evaluated for their capacity to attenuate trace organic compounds (TOrCs), commonly found in municipal wastewater, under closed circuit (current generation) and open circuit (no current generation) conditions, using acetate as the carbon source. A biocide was used to evaluate attenuation in terms of biotransformation versus sorption. The difference in attenuation observed before and after addition of the biocide represented biotransformation, while attenuation after addition of a biocide primarily indicated sorption. Attenuation of TOrCs was similar in MFCs and MECs for eight different TOrCs, except for caffeine and trimethoprim where slightly higher attenuation was observed in MECs. Electric current generation did not enhance attenuation of the TOrCs except for caffeine, which showed slightly higher attenuation under closed circuit conditions in both MFCs and MECs. Substantial sorption of the TOrCs occurred to the biofilm-covered electrodes, but no consistent trend could be identified regarding the physico-chemical properties of the TOrCs tested and the extent of sorption. The octanol-water distribution coefficient at pH 7.4 (log DpH 7.4) appeared to be a reasonable predictor for sorption of some of the compounds (carbamazepine, atrazine, tris(2-chloroethyl) phosphate and diphenhydramine) but not for others (N,N-Diethyl-meta-toluamide). Atenolol also showed high levels of sorption despite being the most hydrophilic in the suite of compounds studied (log DpH 7.4=-1.99). Though BESs do not show any inherent advantages over conventional wastewater treatment, with respect to TOrC removal, overall removals in BESs are similar to that reported for conventional wastewater

  17. Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.

    Jae Sung You

    Full Text Available Signaling by mTOR is a well-recognized component of the pathway through which mechanical signals regulate protein synthesis and muscle mass. However, the mechanisms involved in the mechanical regulation of mTOR signaling have not been defined. Nevertheless, recent studies suggest that a mechanically-induced increase in phosphatidic acid (PA may be involved. There is also evidence which suggests that mechanical stimuli, and PA, utilize ERK to induce mTOR signaling. Hence, we reasoned that a mechanically-induced increase in PA might promote mTOR signaling via an ERK-dependent mechanism. To test this, we subjected mouse skeletal muscles to mechanical stimulation in the presence or absence of a MEK/ERK inhibitor, and then measured several commonly used markers of mTOR signaling. Transgenic mice expressing a rapamycin-resistant mutant of mTOR were also used to confirm the validity of these markers. The results demonstrated that mechanically-induced increases in p70(s6k T389 and 4E-BP1 S64 phosphorylation, and unexpectedly, a loss in total 4E-BP1, were fully mTOR-dependent signaling events. Furthermore, we determined that mechanical stimulation induced these mTOR-dependent events, and protein synthesis, through an ERK-independent mechanism. Similar to mechanical stimulation, exogenous PA also induced mTOR-dependent signaling via an ERK-independent mechanism. Moreover, PA was able to directly activate mTOR signaling in vitro. Combined, these results demonstrate that mechanical stimulation induces mTOR signaling, and protein synthesis, via an ERK-independent mechanism that potentially involves a direct interaction of PA with mTOR. Furthermore, it appears that a decrease in total 4E-BP1 may be part of the mTOR-dependent mechanism through which mechanical stimuli activate protein synthesis.

  18. A Recollection of mTOR Signaling in Learning and Memory

    Graber, Tyson E.; McCamphill, Patrick K.; Sossin, Wayne S.

    2013-01-01

    Mechanistic target of rapamcyin (mTOR) is a central player in cell growth throughout the organism. However, mTOR takes on an additional, more specialized role in the developed neuron, where it regulates the protein synthesis-dependent, plastic changes underlying learning and memory. mTOR is sequestered in two multiprotein complexes (mTORC1 and…

  19. mTOR signaling and its roles in normal and abnormal brain development.

    Nobuyuki eTakei

    2014-04-01

    Full Text Available Target of rapamycin (TOR was first identified in yeast as a target molecule of rapamycin, an anti-fugal and immunosuppressant macrolide compound. In mammals, its orthologue is called mTOR (mammalian TOR. mTOR is a serine/threonine kinase that converges different extracellular stimuli, such as nutrients and growth factors, and diverges into several biochemical reactions, including translation, autophagy, transcription, and lipid synthesis among others. These biochemical reactions govern cell growth and cause cells to attain an anabolic state. Thus, the disruption of mTOR signaling is implicated in a wide array of diseases such as cancer, diabetes, and obesity. In the central nervous system (CNS, the mTOR signaling cascade is activated by nutrients, neurotrophic factors, and neurotransmitters that enhances protein (and possibly lipid synthesis and suppresses autophagy. These processes contribute to normal neuronal growth by promoting their differentiation, neurite elongation and branching, and synaptic formation during development. Therefore, disruption of mTOR signaling may cause neuronal degeneration and abnormal neural development. While reduced mTOR signaling is associated with neurodegeneration, excess activation of mTOR signaling causes abnormal development of neurons and glia, leading to brain malformation. In this review, we first introduce the current state of molecular knowledge of mTOR complexes and signaling in general. We then describe mTOR activation in neurons, which leads to translational enhancement, and finally discuss the link between mTOR and normal/abnormal neuronal growth during development.

  20. Dietary interventions that reduce mTOR activity rescue autistic-like behavioral deficits in mice

    Wu, Jiangbo; de Theije, Caroline G M; da Silva, Sofia Lopes; Abbring, Suzanne; van der Horst, Hilma; Broersen, Laus M; Willemsen, Linette; Kas, Martien; Garssen, Johan; Kraneveld, Aletta D

    Enhanced mammalian target of rapamycin (mTOR) signaling in the brain has been implicated in the pathogenesis of autism spectrum disorder (ASD). Inhibition of the mTOR pathway improves behavior and neuropathology in mouse models of ASD containing mTOR-associated single gene mutations. The current

  1. Overexpression of TOR (target of rapamycin) inhibits cell proliferation in Dictyostelium discoideum.

    Swer, Pynskhem Bok; Mishra, Himanshu; Lohia, Rakhee; Saran, Shweta

    2016-05-01

    TOR (target of rapamycin) protein kinase acts as a central controller of cell growth and development of an organism. Present study was undertaken to find the expression pattern and role of TOR during growth and development of Dictyostelium discoideum. Failures to generate either knockout and/or knockdown mutants indicate that interference with its levels led to cellular defects. Thus, the effects of TOR (DDB_G0281569) overexpression specifically, cells expressing Dd(Δ211-TOR)-Eyfp mutant was analyzed. Elevated expression of (Δ211-TOR)-Eyfp reduced both cell size and cell proliferation. DdTOR was found to be closer to fungus. mRNA level of TOR was found maximally in the freshly starved/aggregate cells that gradually declined. This was also strengthened by the expression patterns observed by in situ and the analysis of β-galactosidase reporter driven by the putative TOR promoter. The TOR protein was found to be highest at the aggregate stage. The fusion protein, (Δ211-TOR)-Eyfp was localized to the cell membrane, cytosol, and the nucleus. We suggest, DdTOR to be an essential protein and high TOR expression inhibits cell proliferation. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Malaysian B5 Implementation and Its Quality

    Liang, Y.C.; Loh, S.K.; Soon, L.W.; May, C.Y.

    2016-01-01

    A quality survey of 80 samples of diesel fuels (B5) from 80 retail stations throughout Peninsular Malaysia was performed. The bio diesel contents in these B5 samples were in the range of 4.61 vol. % to 5.33 vol. %. The water contents of the samples were < 200 mg kg -1 , meeting the stringent water requirements recommended by the car manufacturers. In addition, all the samples exhibited superior lubricity as indicated by a much shorter wear scar diameter compared to neat diesel. More importantly, 98 % of the samples passed the oxidation stability test (PetroOXY) with an induction period of > 65 min. Overall, the B5 diesel fuel sold was in full compliance with the Malaysian diesel fuel standard specification. (author)

  3. Revitalizing the Malaysian Trade Union Movement

    Wad, Peter

    2012-01-01

    The article takes an historic perspective on contemporary issues of trade union revival in Malaysia, focusing on the challenge of raising union density and analysing the process of organizing employees in the strategically important electronics industry. It concludes that the political support...... for transnational corporations in the electronics industry is declining. This strategic shift enables union activists to bypass enterprise and state-based unions and to establish larger, regionally based unions. However, newly organized unions have not yet overcome resistance from global corporations, nor have...... organizations prefer non-partisan engagement. In order to revitalize themselves, the unions must demonstrate to the Malaysian public that they are both relevant and important for increased productivity and that they can play a significant role in enabling Malaysia to move beyond the middle-income ‘trap’ towards...

  4. Wave power potential in Malaysian territorial waters

    Asmida Mohd Nasir, Nor; Maulud, Khairul Nizam Abdul

    2016-06-01

    Up until today, Malaysia has used renewable energy technology such as biomass, solar and hydro energy for power generation and co-generation in palm oil industries and also for the generation of electricity, yet, we are still far behind other countries which have started to optimize waves for similar production. Wave power is a renewable energy (RE) transported by ocean waves. It is very eco-friendly and is easily reachable. This paper presents an assessment of wave power potential in Malaysian territorial waters including waters of Sabah and Sarawak. In this research, data from Malaysia Meteorology Department (MetMalaysia) is used and is supported by a satellite imaginary obtained from National Aeronautics and Space Administration (NASA) and Malaysia Remote Sensing Agency (ARSM) within the time range of the year 1992 until 2007. There were two types of analyses conducted which were mask analysis and comparative analysis. Mask analysis of a research area is the analysis conducted to filter restricted and sensitive areas. Meanwhile, comparative analysis is an analysis conducted to determine the most potential area for wave power generation. Four comparative analyses which have been carried out were wave power analysis, comparative analysis of wave energy power with the sea topography, hot-spot area analysis and comparative analysis of wave energy with the wind speed. These four analyses underwent clipping processes using Geographic Information System (GIS) to obtain the final result. At the end of this research, the most suitable area to develop a wave energy converter was found, which is in the waters of Terengganu and Sarawak. Besides that, it was concluded that the average potential energy that can be generated in Malaysian territorial waters is between 2.8kW/m to 8.6kW/m.

  5. Inactivation of Tor proteins affects the dynamics of endocytic proteins ...

    2013-04-26

    Apr 26, 2013 ... Tor2 is an activator of the Rom2/Rho1 pathway that regulates α-factor internalization. Since the recruitment of .... particular, with the help of real-time live-cell imaging of. GFP-fusion ... 2.1 Yeast strain construction and media.

  6. Waterfilling: Balancing the Tor network with maximum diversity

    Rochet Florentin

    2017-04-01

    Full Text Available We present the Waterfilling circuit selection method, which we designed in order to mitigate the risks of a successful end-to-end traffic correlation attack. Waterfilling proceeds by balancing the Tor network load as evenly as possible on endpoints of user paths. We simulate the use of Waterfilling thanks to the TorPS and Shadow tools. Applying several security metrics, we show that the adoption of Waterfilling considerably increases the number of nodes that an adversary needs to control in order to be able to mount a successful attack, while somewhat decreasing the minimum amount of bandwidth required to do so. Moreover, we evaluate Waterfilling in Shadow and show that it does not impact significantly the performance of the network. Furthermore, Waterfilling reduces the benefits that an attacker could obtain by hacking into a top bandwidth Tor relay, hence limiting the risks raised by such relays. Waterfilling does not require any major change in Tor, and can co-exist with the current circuit selection algorithm.

  7. Attenuation of trace organic compounds (TOrCs) inbioelectrochemical systems

    Werner, Craig M.; Hoppe-Jones, Christiane; Saikaly, Pascal; Logan, Bruce E.; Amy, Gary L.

    2015-01-01

    , but no consistent trend could be identified regarding the physico-chemical properties of the TOrCs tested and the extent of sorption. The octanol-water distribution coefficient at pH 7.4 (log DpH 7.4) appeared to be a reasonable predictor for sorption of some

  8. Evolutionary Conservation of the Components in the TOR Signaling Pathways.

    Tatebe, Hisashi; Shiozaki, Kazuhiro

    2017-11-01

    Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that controls multiple cellular processes upon various intracellular and extracellular stimuli. Since its first discovery, extensive studies have been conducted both in yeast and animal species including humans. Those studies have revealed that TOR forms two structurally and physiologically distinct protein complexes; TOR complex 1 (TORC1) is ubiquitous among eukaryotes including animals, yeast, protozoa, and plants, while TOR complex 2 (TORC2) is conserved in diverse eukaryotic species other than plants. The studies have also identified two crucial regulators of mammalian TORC1 (mTORC1), Ras homolog enriched in brain (RHEB) and RAG GTPases. Of these, RAG regulates TORC1 in yeast as well and is conserved among eukaryotes with the green algae and land plants as apparent exceptions. RHEB is present in various eukaryotes but sporadically missing in multiple taxa. RHEB, in the budding yeast Saccharomyces cerevisiae , appears to be extremely divergent with concomitant loss of its function as a TORC1 regulator. In this review, we summarize the evolutionarily conserved functions of the key regulatory subunits of TORC1 and TORC2, namely RAPTOR, RICTOR, and SIN1. We also delve into the evolutionary conservation of RHEB and RAG and discuss the conserved roles of these GTPases in regulating TORC1.

  9. Three-dimensional facial analyses of Indian and Malaysian women.

    Kusugal, Preethi; Ruttonji, Zarir; Gowda, Roopa; Rajpurohit, Ladusingh; Lad, Pritam; Ritu

    2015-01-01

    Facial measurements serve as a valuable tool in the treatment planning of maxillofacial rehabilitation, orthodontic treatment, and orthognathic surgeries. The esthetic guidelines of face are still based on neoclassical canons, which were used in the ancient art. These canons are considered to be highly subjective, and there is ample evidence in the literature, which raises such questions as whether or not these canons can be applied for the modern population. This study was carried out to analyze the facial features of Indian and Malaysian women by using three-dimensional (3D) scanner and thus determine the prevalence of neoclassical facial esthetic canons in both the groups. The study was carried out on 60 women in the age range of 18-25 years, out of whom 30 were Indian and 30 Malaysian. As many as 16 facial measurements were taken by using a noncontact 3D scanner. Unpaired t-test was used for comparison of facial measurements between Indian and Malaysian females. Two-tailed Fisher exact test was used to determine the prevalence of neoclassical canons. Orbital Canon was prevalent in 80% of Malaysian women; the same was found only in 16% of Indian women (P = 0.00013). About 43% of Malaysian women exhibited orbitonasal canon (P = 0.0470) whereas nasoaural canon was prevalent in 73% of Malaysian and 33% of Indian women (P = 0.0068). Orbital, orbitonasal, and nasoaural canon were more prevalent in Malaysian women. Facial profile canon, nasooral, and nasofacial canons were not seen in either group. Though some canons provide guidelines in esthetic analyses of face, complete reliance on these canons is not justifiable.

  10. GTPase ROP2 binds and promotes activation of target of rapamycin, TOR, in response to auxin.

    Schepetilnikov, Mikhail; Makarian, Joelle; Srour, Ola; Geldreich, Angèle; Yang, Zhenbiao; Chicher, Johana; Hammann, Philippe; Ryabova, Lyubov A

    2017-04-03

    Target of rapamycin (TOR) promotes reinitiation at upstream ORFs (uORFs) in genes that play important roles in stem cell regulation and organogenesis in plants. Here, we report that the small GTPase ROP2, if activated by the phytohormone auxin, promotes activation of TOR, and thus translation reinitiation of uORF-containing mRNAs. Plants with high levels of active ROP2, including those expressing constitutively active ROP2 (CA-ROP2), contain high levels of active TOR ROP2 physically interacts with and, when GTP-bound, activates TOR in vitro TOR activation in response to auxin is abolished in ROP-deficient rop2 rop6 ROP4 RNAi plants. GFP-TOR can associate with endosome-like structures in ROP2-overexpressing plants, indicating that endosomes mediate ROP2 effects on TOR activation. CA-ROP2 is efficient in loading uORF-containing mRNAs onto polysomes and stimulates translation in protoplasts, and both processes are sensitive to TOR inhibitor AZD-8055. TOR inactivation abolishes ROP2 regulation of translation reinitiation, but not its effects on cytoskeleton or intracellular trafficking. These findings imply a mode of translation control whereby, as an upstream effector of TOR, ROP2 coordinates TOR function in translation reinitiation pathways in response to auxin. © 2017 The Authors.

  11. The nuclear import of ribosomal proteins is regulated by mTOR

    Kazyken, Dubek; Kaz, Yelimbek; Kiyan, Vladimir; Zhylkibayev, Assylbek A.; Chen, Chien-Hung; Agarwal, Nitin K.; Sarbassov, Dos D.

    2014-01-01

    Mechanistic target of rapamycin (mTOR) is a central component of the essential signaling pathway that regulates cell growth and proliferation by controlling anabolic processes in cells. mTOR exists in two distinct mTOR complexes known as mTORC1 and mTORC2 that reside mostly in cytoplasm. In our study, the biochemical characterization of mTOR led to discovery of its novel localization on nuclear envelope where it associates with a critical regulator of nuclear import Ran Binding Protein 2 (RanBP2). We show that association of mTOR with RanBP2 is dependent on the mTOR kinase activity that regulates the nuclear import of ribosomal proteins. The mTOR kinase inhibitors within thirty minutes caused a substantial decrease of ribosomal proteins in the nuclear but not cytoplasmic fraction. Detection of a nuclear accumulation of the GFP-tagged ribosomal protein rpL7a also indicated its dependence on the mTOR kinase activity. The nuclear abundance of ribosomal proteins was not affected by inhibition of mTOR Complex 1 (mTORC1) by rapamycin or deficiency of mTORC2, suggesting a distinctive role of the nuclear envelope mTOR complex in the nuclear import. Thus, we identified that mTOR in association with RanBP2 mediates the active nuclear import of ribosomal proteins. PMID:25294810

  12. Growth in Malaysian Demand for Business Education--the Australian Response.

    Lewis, Philip E. T.; Pratt, Graham R.

    1996-01-01

    Increasing Malaysian demand for business education is examined from the perspective of Australia, one of the largest suppliers to the region. Topics discussed include: origins and nature of the demand; Malaysian enrollment patterns in Australia; "twinning programs," in which a Malaysian college and a foreign university collaborate to…

  13. The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals.

    Tan, Heng Kean; Moad, Ahmed Ismail Hassan; Tan, Mei Lan

    2014-01-01

    The mammalian target of rapamycin (mTOR) kinase plays an important role in regulating cell growth and cell cycle progression in response to cellular signals. It is a key regulator of cell proliferation and many upstream activators and downstream effectors of mTOR are known to be deregulated in various types of cancers. Since the mTOR signalling pathway is commonly activated in human cancers, many researchers are actively developing inhibitors that target key components in the pathway and some of these drugs are already on the market. Numerous preclinical investigations have also suggested that some herbs and natural phytochemicals, such as curcumin, resveratrol, timosaponin III, gallic acid, diosgenin, pomegranate, epigallocatechin gallate (EGCC), genistein and 3,3'-diindolylmethane inhibit the mTOR pathway either directly or indirectly. Some of these natural compounds are also in the clinical trial stage. In this review, the potential anti-cancer and chemopreventive activities and the current status of clinical trials of these phytochemicals are discussed.

  14. TOR-Dependent and -Independent Pathways Regulate Autophagy in Arabidopsis thaliana.

    Pu, Yunting; Luo, Xinjuan; Bassham, Diane C

    2017-01-01

    Autophagy is a critical process for recycling of cytoplasmic materials during environmental stress, senescence and cellular remodeling. It is upregulated under a wide range of abiotic stress conditions and is important for stress tolerance. Autophagy is repressed by the protein kinase target of rapamycin (TOR), which is activated in response to nutrients and in turn upregulates cell growth and translation and inhibits autophagy. Down-regulation of TOR in Arabidopsis thaliana leads to constitutive autophagy and to decreased growth, but the relationship to stress conditions is unclear. Here, we assess the extent to which TOR controls autophagy activation by abiotic stress. Overexpression of TOR inhibited autophagy activation by nutrient starvation, salt and osmotic stress, indicating that activation of autophagy under these conditions requires down-regulation of TOR activity. In contrast, TOR overexpression had no effect on autophagy induced by oxidative stress or ER stress, suggesting that activation of autophagy by these conditions is independent of TOR function. The plant hormone auxin has been shown previously to up-regulate TOR activity. To confirm the existence of two pathways for activation of autophagy, dependent on the stress conditions, auxin was added exogenously to activate TOR, and the effect on autophagy under different conditions was assessed. Consistent with the effect of TOR overexpression, the addition of the auxin NAA inhibited autophagy during nutrient deficiency, salt and osmotic stress, but not during oxidative or ER stress. NAA treatment was unable to block autophagy induced by a TOR inhibitor or by a mutation in the TOR complex component RAPTOR1B , indicating that auxin is upstream of TOR in the regulation of autophagy. We conclude that repression of auxin-regulated TOR activity is required for autophagy activation in response to a subset of abiotic stress conditions.

  15. Evolutionary conservation of TORC1 components, TOR, Raptor, and LST8, between rice and yeast.

    Maegawa, Kentaro; Takii, Rumi; Ushimaru, Takashi; Kozaki, Akiko

    2015-10-01

    Target of rapamycin (TOR) is a conserved eukaryotic serine/threonine kinase that functions as a central controller of cell growth. TOR protein is structurally defined by the presence several conserved domains such as the HEAT repeat, focal adhesion target (FAT), FKBP12/rapamycin binding (FRB), kinase, and FATC domains starting from the N-terminus. In most eukaryotes, TOR forms two distinct physical and functional complexes, which are termed as TOR complex 1 (TORC1) and TORC2. However, plants contain only TORC1 components, i.e., TOR, Raptor, and LST8. In this study, we analyzed the gene structure and functions of TORC components in rice to understand the properties of the TOR complex in plants. Comparison of the locations of introns in these genes among rice and other eukaryotes showed that they were well conserved among plants except for Chlamydomonas. Moreover, the intron positions in the coding sequence of human Raptor and LST8 were closer to those of plants than of fly or nematode. Complementation tests of rice TOR (OsTOR) components in yeast showed that although OsTOR did not complement yeast tor mutants, chimeric TOR, which consisted of the HEAT repeat and FAT domain from yeast and other regions from rice, rescued the tor mutants, indicating that the HEAT repeat and FAT domains are important for species-specific signaling. OsRaptor perfectly complemented a kog1 (yeast Raptor homolog) mutant, and OsLST8 partially complemented an lst8 mutant. Together, these data suggest the importance of the N-terminal region of the TOR, HEAT, and FAT domains for functional diversification of the TOR complex.

  16. Utility of the Canadian Treatment Optimization Recommendations (TOR) in MS care.

    Grand'Maison, François; Bhan, Virender; Freedman, Mark S; Myles, Mary L; Patry, David G; Selchen, Daniel H; Moriarty, Patrick; Traboulsee, Anthony L

    2013-07-01

    Criteria for Treatment Optimization Recommendations (TOR) for patients with multiple sclerosis (MS) identify suboptimal response to disease-modifying treatment (DMT). The Canadian TOR (CanTOR) were used to indicate recommendations for treatment switches or treatment maintenance based on relapse, disease progression and magnetic resonance imaging (MRI) criteria in patients. We assessed concordance between the TOR and clinicians' decisions regarding treatment response and identified prevalence of patients with MS receiving DMT meeting medium/high levels of concern according to TOR. Prospective baseline and end-of-study assessments of patients with relapsing-remitting MS (RRMS) or clinically isolated syndrome were conducted in this open-label, 12-month, Phase IV, observational Canadian study. Data were reported for 184 patients (female 72%, mean age 39 years) of which 96% had RRMS. The TOR criteria identified 19 (10.3%) patients with suboptimal response to treatment. Twelve patients had ≥1 high level of concern. Two patients had ≥2 medium levels of concern. Concordance between TOR and clinician decision in maintaining treatment was 95.3%. Where treatment change was recommended by the TOR, concordance was 29.4%. Clinicians identified the TOR as the principal reason for changing treatment in 50.0% of cases where the TOR identified suboptimal response. The TOR were considered useful by 70.6% of clinicians when treatment optimization was recommended and by 55.3% when maintaining treatment was recommended. The TOR criteria can identify suboptimal response in this patient cohort. Concordance between TOR and clinician decision was high when maintaining treatment was recommended. Usefulness of the TOR was most apparent when treatment optimization was recommended.

  17. Fictionalized History: Signifying Changes to the Malaysian Nation and Identity

    Sim Chee Cheang

    2016-04-01

    Full Text Available As one of the cornerstones of fiction, writers often use and confront history in their claim to “reality” and “identity” in their writing. Linda Hutcheon’s claim for “a postmodern concern for the multiplicity and dispersion of truth(s; truth(s relative to the specificity of place and culture” (1988, p. 108 is relevant to the use of history in recent Malaysian literature. The multiple and varied claims of truth(s as reflected through the fictionalizing of Malaysian history is the focus of the analysis in this article, which aims to expose the social, economic, and political implications of the Malaysian identity. The analysis of three current works of fictionalized Malaysian history from the different fictional genres of comic series, children’s history, and occidental history, represents a cross section of genres that challenge the supremacy of history’s ontological claim over identity. The deliberate contestation of received Malaysian history in fictional modes acknowledges the peripheral identity structures of race, religion, and economics that are sensitive in a multiracial country such as Malaysia.

  18. Relationship between oral hygiene and gingival condition of Malaysian students

    Muhammad Arif Mohd Marsin

    2018-01-01

    Full Text Available The primary etiologic agent of gingival disease was dental plaque which also involving the oral hygiene. The oral hygiene can be affected by individuals knowledge, attitude, practice, environment, and others. The purpose of this study was to assess the relationship between oral hygiene and gingival condition of Malaysian students. The type of this study was cross-sectional study. The study was conducted on a total of 66 Malaysian students. The data were collected by using an examination form and clinical examination using the Loe & Sillness gingival index followed by the Loe & Sillness plaque index. The results showed that 100% of students have gingivitis with the gingival index average of 1.25 and the plaque index average of 1.85. The relationship of gingival and plaque index was analyzed by using Spearman’s Rank Correlation Coefficient test, and the score was 0.623. It is concluded that the oral hygiene status of Malaysian students was in the fair category, and all Malaysian students had a moderate gingivitis. Also, there was a relationship between the oral hygiene status and gingival condition of Malaysian students.

  19. Your choice MATor(s) : large-scale quantitative anonymity assessment of Tor path selection algorithms against structural attacks

    Backes, Michael; Meiser, Sebastian; Slowik, Marcin

    2015-01-01

    In this paper, we present a rigorous methodology for quantifying the anonymity provided by Tor against a variety of structural attacks, i.e., adversaries that compromise Tor nodes and thereby perform eavesdropping attacks to deanonymize Tor users. First, we provide an algorithmic approach for computing the anonymity impact of such structural attacks against Tor. The algorithm is parametric in the considered path selection algorithm and is, hence, capable of reasoning about variants of Tor and...

  20. The Development of a Green Practice Index for the Malaysian Hotel Industry

    A. K. Siti–Nabiha

    2014-03-01

    Malaysian hotels. Doing so, however, resulted in a search for green index development methods. This lead to the discovery that existing tools such as the Delphi method were not appropriate tools that could be used to develop a Malaysian green index. To address the above, the authors propose a green index development method that can be used for a  Malaysian and developing country context. Hence, in this paper, the method of developing a green practice index for the Malaysian hospitality industry, the differences and advantages of this method compared to the commonly used Delphi method and finally the Malaysian Green Practice Index for the hotel industry are presented.

  1. The Malaysian state's response to migration.

    Pillai, P

    1999-04-01

    This paper aims to provide a profile of migration trends in Malaysia since 1970 and to analyze public policy on migration in the context of economic growth and the labor market. The discussion centers on the impact of the Asian financial crisis. There is long history of immigration to Malaysia. The development strategy of the 1970s and 1980s was to create more jobs and restructure employment to meet equity goals. Labor shortages on plantations and construction booms led to a more organized, sustained effort to import labor. Recession in the mid-1980s led to unemployment, but many Malaysians were unwilling to work on plantations, in construction, or in low paying jobs. Economic growth during 1987-96 was very high, and labor shortages spread to service and manufacturing sectors. Migration policy has shifted over the decades. Both the market and the government's promotion of export-based industrialization require access to low cost migrant labor. Public and official recognition of the large number of migrants was not made until 1995. The financial crisis in 1998 led to enforcement of a new migration policy on illegal migrants and greater outflow of migrants. The economic crisis has increased job and income inequities in the region; this encourages continued migration. It is argued that it would be best for Malaysia to maximize short-term gains while minimizing long-term economic, social, and political costs.

  2. Global Financial Crisis and Philanthropy: Malaysian Case

    Janice Lay Hui Nga

    2015-08-01

    Full Text Available This paper investigates the issue of the global financial crisis and its impacts on philanthropy and civil society organisations (CSOs in Malaysia. CSOs are popularly known as non-governmental organisations (NGOs in Malaysia. Financial crisis has caused NGOs in many countries to receive less funding. This situation may threaten and discourage voluntary works. Undoubtedly, these beneficial contributions from the NGOs are needful services to the society. This paper examines the impact of financial crisis through the lens of NGOs and philanthropy activities in Malaysia. It utilises primary and secondary data, employs a mixed method approach, and uses quantitative and qualitative data. While there are many influencing factors in this development, this paper presents several significant aspects in the Malaysian context, including the style and nature of giving, culture, religion, and political pressure. This study attempts to seek potential solutions, pathways and possible approaches beneficial to NGOs and philanthropy activities for their sustainability in facing the financial crisis and its consequences. Experiences and lessons learnt in Malaysia may well be useful and applicable to some extent in other countries.

  3. Lifestyle Practices and Obesity in Malaysian Adolescents

    Teo, Pey Sze; Nurul-Fadhilah, Abdullah; Aziz, Mohd Ezane; Hills, Andrew P.; Foo, Leng Huat

    2014-01-01

    Aim: To determine the influence of physical activity (PA) and sedentary behavior (SB) on obesity profiles of 454 Malaysian adolescents aged 12 to 19. Methods: Validated PA and SB questionnaires were used and body composition assessed using anthropometry and dual-energy X-ray absorptiometry (DXA). Results: Gender-specific multivariate analyses showed boys with high levels of total PA and moderate-to-vigorous physical activity (MVPA) exhibited significantly lower levels of total body fat, percent body fat and android fat mass compared with low PA and MVPA groups, after adjusting for potential confounders. Girls with high SB levels showed significantly higher BMI, waist circumference and DXA-derived body fat indices than those at lower SB level. Multiple logistic analyses indicated that boys with low levels of total PA and MVPA had significantly greater obesity risk, 3.0 (OR 3.0; 95% CI, 1.1–8.1; p obesity, 2.9 times higher than girls at low SP levels (OR 2.8; 95% CI, 1.0–7.5; p obesity risk while high screen-based sedentary behaviors significantly adversely influenced body fat mass, particularly amongst girls when the PA level was low. PMID:24886753

  4. Radiation Protection Officer certification scheme. Malaysian experience

    Pungut, Noraishah; Razali, Noraini; Mod Ali, Noriah

    2011-01-01

    In Malaysia, the need for maintaining competency in radiation protection is emerging, focusing on the qualification of Radiation Protection Officers (RPO). Regulation 23 of Malaysian Radiation Protection (Basic Safety Standards) Regulations 1988, requires the applicant to employ an RPO, with the necessary knowledge, skill and training, enabling effective protection of individuals and minimizing danger to life, property and the environment for all activities sought to be licensed. An RPO must demonstrate the knowledge required, by attending RPO courses organised by an accredited agency and pass the RPO certification examination. Maintaining a high level of competency is crucial for future development of safe applications of ionising radiation. The major goal of training is to provide essential knowledge and skills and to foster correct attitudes on radiation protection and safe use of radiation sources. Assessment of the competency is through theoretical and practical examination. A standard criterion on the performance of the individuals evaluated has been established and only those who meet this criterion can be accepted as certified RPO. The National Committee for the Certification of Radiation Protection Officer (NCCRPO), comprising experts in various fields, is responsible to review and update requirements on competency of a certified RPO. With increasing number of candidates (i.e. 701 in 2008) and the international requirement for radioactive source security, it is incumbent upon the NCCRPO to improve the syllabus of the certification scheme. The introduction of a Radiation Protection Advisor (RPA) to provide service and advice to the radiation industry in Malaysia is also seriously considered. (author)

  5. The Malaysian Robotic Solar Observatory (P29)

    Othman, M.; Asillam, M. F.; Ismail, M. K. H.

    2006-11-01

    Robotic observatory with small telescopes can make significant contributions to astronomy observation. They provide an encouraging environment for astronomers to focus on data analysis and research while at the same time reducing time and cost for observation. The observatory will house the primary 50cm robotic telescope in the main dome which will be used for photometry, spectroscopy and astrometry observation activities. The secondary telescope is a robotic multi-apochromatic refractor (maximum diameter: 15 cm) which will be housed in the smaller dome. This telescope set will be used for solar observation mainly in three different wavelengths simultaneously: the Continuum, H-Alpha and Calcium K-line. The observatory is also equipped with an automated weather station, cloud & rain sensor and all-sky camera to monitor the climatic condition, sense the clouds (before raining) as well as to view real time sky view above the observatory. In conjunction with the Langkawi All-Sky Camera, the observatory website will also display images from the Malaysia - Antarctica All-Sky Camera used to monitor the sky at Scott Base Antarctica. Both all-sky images can be displayed simultaneously to show the difference between the equatorial and Antarctica skies. This paper will describe the Malaysian Robotic Observatory including the systems available and method of access by other astronomers. We will also suggest possible collaboration with other observatories in this region.

  6. Quality system in Malaysian National Tissue Bank

    Go Boon Thong; Firdaus, M. N.; Abd Rani Shamsudin

    1999-01-01

    Quality System in Malaysian National Tissue Bank is based on the Quality Manual which has been drawn up by the chairman, who is the Dean, School of Medical Sciences. The Quality Manual include general standard for Tissue Banking in University Science of Malaysia which describe and explain a set of general standard similar to the EATB standard. The primary aim of the quality system is to produce a safe and effective tissue graft for successful clinical use and to ensure the safety of tissue bank operators. The Quality Manual also related the role of a Technical Manual, which explain the standard of technical aspect of tissue bank in a Quality Assurance. The safe working environment and Good Laboratory Practice is highlight in Quality System. Documentation of tissue bank activities is the key to the administration to tissue bank. Finally Quality System in tissue banking will never be complete without a Tissue Bank Auditing System which allow the tissue bank coordinator and staff to look into the problem and further enhance the progress of the tissue bank

  7. Development and promotion of Malaysian Dietary Guidelines.

    Tee, E-Siong

    2011-01-01

    Development and promotion of dietary guidelines is one of the key activities outlined in the National Plan of Action for Nutrition of Malaysia for the prevention of nutrition-related disorders. The first official Malaysian Dietary Guidelines (MDG) was published in 1999 and was thoroughly reviewed and launched on 25 March 2010. The new MDG 2010 is a compilation of science-based nutrition and physical activity recommendations. These guidelines form the basis of consistent and scientifically sound nutrition messages for the public. There are 14 key messages and 55 recommendations, covering the whole range of food and nutrition issues, from importance of consuming a variety of foods to guidance on specific food groups, messages to encourage physical activities, consuming safe food and beverages and making effective use of nutrition information on food labels. The MDG also has an updated food pyramid. Various efforts have been made to ensure that the revised MDG is disseminated to all stakeholders. The Ministry of Health has organised a series of workshops for nutritionists and other health care professionals, and the food industry. In collaboration with other professional bodies and the private sector, the Nutrition Society of Malaysia has been promoting the dissemination and usage of the MDG to the public through a variety of formats and channels. These include the publication of a series of leaflets, educational press articles, educational booklets, as well as through educational activities for children. It is imperative to monitor the usage and evaluation of these dietary messages.

  8. Musculoskeletal injuries among Malaysian badminton players.

    Shariff, A H; George, J; Ramlan, A A

    2009-11-01

    The purpose of this study was to investigate the pattern of musculoskeletal injuries sustained by Malaysian badminton players. This is a retrospective case notes review of all badminton players who attended the National Sports Institute (NSI) Clinic, Kuala Lumpur, Malaysia, and were diagnosed with musculoskeletal injuries. In a two and a half year period, from January 2005 to June 2007, 469 musculoskeletal injuries were diagnosed among badminton players at the NSI Clinic. The mean age of the players who attended the clinic was 19.2 (range 13-52) years. Approximately 60 percent of the injuries occurred in players younger than 20 years of age. The majority of injuries (91.5 percent) were categorised as mild overuse injury and mostly involved the knee. The majority of the injuries sustained by badminton players in this study were due to overuse, primarily in the knee. The majority of the injuries were diagnosed in younger players and occurred during training/practice sessions. There was no difference in terms of incidence and types of injuries between the genders.

  9. Issues and Problems in Malaysian Contemporary Visual Arts

    Mohamad Faizuan Mat

    2016-06-01

    Full Text Available In Malaysia, there is a question in term of intellectualism activities in the context of visual epistemology. Therefore, this paper revealed the problems that linger in the Malaysian contemporary visual art scene. In fact, Malaysian contemporary artists appear to have insufficient intellectualism values and less discourse activities. The lacks of scholars in the field of visual arts create a gap in the visual arts scene in Malaysia. The question of this study was to uncover the main problems in Malaysian visual arts that led to the problem of art intellectual development. In addition, this paper presents the awareness of the valuable contributions in the intellectual development that able to enhance the communication in the art object.Keywords: art knowledge; art object; contemporary art; interpretation; perception;

  10. Assessing Quality of Working Life Among Malaysian Workers.

    Sulaiman, Nur Suffia; Choo, Wan Yuen; Mat Yassim, Abdul Rahim; Van Laar, Darren; Chinna, Karuthan; Majid, Hazreen Abdul

    2015-11-01

    The Work-Related Quality of Life Scale-2 (WRQLS-2) has been used to measure quality of working life (QOWL) in the United Kingdom. In this study, the scale was translated and normalized into Malay. The scale was translated using the back-translation method, pretesting, and pilot testing. It was conducted among health care and office workers. It was tested in 3 stages; confirmatory factor analysis at stages 1 and 3 and exploratory factor analysis at stage 2. The Malaysian WRQLS-2 had 5 factors: "General Well-Being," "Job and Career Satisfaction," "Employee Engagement," "Home-Work Interface," and "Stress at Work." The scale showed good convergent and construct validity and also reliability. Perception of good QOWL may differ because of cultural influences and varying work environments. The validated Malaysian WRQLS-2 can be used to determine the QOWL of Malaysian office and health care workers. © 2015 APJPH.

  11. Malaysian Preparation for Nuclear Power Plant Instrumentation and Control System

    Mohd Idris Taib; Nurfarhana Ayuni Joha; Kamarudin Sulaiman; Izhar Abu Hussin

    2011-01-01

    Instrumentation and Control System is required in Nuclear Power Plant for their safe and effective operation. The system is combination and integrated from detectors, actuators, analog system as well as digital system. Current design of system definitely follows of electronic as well as computer technology, with strictly follow regulation and guideline from local regulator as well as International Atomic Energy Agency. Commercial Off-The-Shelf products are extensively used with specific nucleonic instrumentation. Malaysian experiences depend on Reactor TRIGA PUSPATI Instrumentation and Control, Power Plant Instrumentation and Control as well as Process Control System. However Malaysians have capabilities to upgrade themself from Electronics, Computers, Electrical and Mechanical based. Proposal is presented for Malaysian preparation. (author)

  12. FACTORS INFLUENCING YIELD SPREADS OF THE MALAYSIAN BONDS

    Norliza Ahmad

    2009-01-01

    Full Text Available Malaysian bond market is developing rapidly but not much is understood in terms of macroeconomic factors that could influence the yield spread of the Ringgit Malaysian denominated bonds. Based on a multifactor model, this paper examines the impact of four macroeconomic factors namely: Kuala Lumpur Composite Index (KLCI, Industry Production Index (IPI, Consumer Price Index (CPI and interest rates (IR on bond yield spread of the Malaysian Government Securities (MGS and Corporate Bonds (CBs for a period from January 2001 to December 2008. The findings support the expected hypotheses that CPI and IR are the major drivers that influence the changes in MGS yield spreads. However IPI and KLCI have weak and no influence on MGS yield spreads respectively Whilst IR, CPI and IPI have significant influence on the yield spreads of CB1, CB2 and CB3, KLCI has significant influence only on the CB1 yield spread but not on CB2 and CB3 yield spreads.

  13. Malaysian nurses' evaluation of transnational higher education courses.

    Arunasalam, Nirmala

    The internationalisation of higher education has led some UK and Australian universities to deliver transnational higher education (TNHE) post-registration top-up nursing degree courses in Malaysia. These are bridging courses that allow registered nurses to upgrade their diploma qualifications to degree level. What is not sufficiently explored in the literature is nurses' evaluation of these courses and the impact of TNHE qualifications. A hermeneutic phenomenology approach was used to explore the views of 18 Malaysian nurses from one Australian and two UK TNHE universities. Semi-structured interviews were conducted to enable the Malaysian nurses to evaluate the courses. Data were analysed by thematic analysis. Findings showed a gap between Malaysian and Western teaching and learning outlook, professional values and clinical practices. The data give important insights at a time when the aim of Malaysia's investment in TNHE courses is to attain a graduate workforce with changed mindsets and enhanced patient care.

  14. Control Management and Business Performances: The Malaysian Family SMEs Perspectives

    Edward Wong Sek Khin

    2015-06-01

    Full Text Available This study examined the relationship between control management and family business performance in the Malaysian context. It has two objectives, the first being to determine the relationship of organizational credit control policy and procedures, employee development and motivation, and intelligence collection systems to subsequent collection reports in Malaysian family SMEs. The second objective is to investigate the moderating effect of participation in decision-making and work effort towards innovation and business performance. This is a descriptive study involving 90 senior executives employed in 90 Malaysian family SMEs/firms. A correlation analysis from this study confirmed previous researchers’ observations that high-level organizational commitment to credit control management is linked to improvements in business performance. The results suggest that three components – credit policy, employee development, and intelligence collection systems – are the most important predictors for the efficiency and effectiveness of credit control management.    

  15. Traditional Postpartum Practices Among Malaysian Mothers: A Review.

    Fadzil, Fariza; Shamsuddin, Khadijah; Wan Puteh, Sharifa Ezat

    2016-07-01

    To briefly describe the postpartum practices among the three major ethnic groups in Malaysia and to identify commonalities in their traditional postpartum beliefs and practices. This narrative review collated information on traditional postpartum practices among Malaysian mothers through a literature search for published research papers on traditional postpartum practices in Malaysia. This review shows that Malaysian mothers have certain postpartum practices that they considered to be important for preventing future ill health. Despite the perceived differences in intra-ethnic postpartum practices, most Malaysian mothers, although from different ethnicities, share similarities in their postpartum regimens and practices in terms of beliefs and adherence to food taboos, use of traditional postpartum massage and traditional herbs, and acknowledgment of the role of older female family members in postpartum care. Health care providers should be aware of multiethnic traditional postpartum practices and use the commonalities in these practices as part of their postpartum care regimen.

  16. Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

    Park, Dohyun; Jeong, Heeyoon; Lee, Mi Nam; Koh, Ara; Kwon, Ohman; Yang, Yong Ryoul; Noh, Jungeun; Suh, Pann-Ghill; Park, Hwangseo; Ryu, Sung Ho

    2016-01-01

    Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, such as reduction of inflammation and induction of cancer cell death. Although various resveratrol targets have been suggested, the molecule that mediates resveratrol-induced autophagy remains unknown. Here, we demonstrate that resveratrol induces autophagy by directly inhibiting the mTOR-ULK1 pathway. We found that inhibition of mTOR activity and presence of ULK1 are required for autophagy induction by resveratrol. In line with this mTOR dependency, we found that resveratrol suppresses the viability of MCF7 cells but not of SW620 cells, which are mTOR inhibitor sensitive and insensitive cancer cells, respectively. We also found that resveratrol-induced cancer cell suppression occurred ULK1 dependently. For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. We found that resveratrol inhibits mTOR by docking onto the ATP-binding pocket of mTOR (i.e., it competes with ATP). We propose mTOR as a novel direct target of resveratrol, and inhibition of mTOR is necessary for autophagy induction. PMID:26902888

  17. Tor forms a dimer through an N-terminal helical solenoid with a complex topology

    Baretić, Domagoj; Berndt, Alex; Ohashi, Yohei; Johnson, Christopher M.; Williams, Roger L.

    2016-04-01

    The target of rapamycin (Tor) is a Ser/Thr protein kinase that regulates a range of anabolic and catabolic processes. Tor is present in two complexes, TORC1 and TORC2, in which the Tor-Lst8 heterodimer forms a common sub-complex. We have determined the cryo-electron microscopy (EM) structure of Tor bound to Lst8. Two Tor-Lst8 heterodimers assemble further into a dyad-symmetry dimer mediated by Tor-Tor interactions. The first 1,300 residues of Tor form a HEAT repeat-containing α-solenoid with four distinct segments: a highly curved 800-residue N-terminal 'spiral', followed by a 400-residue low-curvature 'bridge' and an extended `railing' running along the bridge leading to the 'cap' that links to FAT region. This complex topology was verified by domain insertions and offers a new interpretation of the mTORC1 structure. The spiral of one TOR interacts with the bridge of another, which together form a joint platform for the Regulatory Associated Protein of TOR (RAPTOR) regulatory subunit.

  18. A Legume TOR Protein Kinase Regulates Rhizobium Symbiosis and Is Essential for Infection and Nodule Development.

    Nanjareddy, Kalpana; Blanco, Lourdes; Arthikala, Manoj-Kumar; Alvarado-Affantranger, Xóchitl; Quinto, Carmen; Sánchez, Federico; Lara, Miguel

    2016-11-01

    The target of rapamycin (TOR) protein kinase regulates metabolism, growth, and life span in yeast, animals, and plants in coordination with nutrient status and environmental conditions. The nutrient-dependent nature of TOR functionality makes this kinase a putative regulator of symbiotic associations involving nutrient acquisition. However, TOR's role in these processes remains to be understood. Here, we uncovered the role of TOR during the bean (Phaseolus vulgaris)-Rhizobium tropici (Rhizobium) symbiotic interaction. TOR was expressed in all tested bean tissues, with higher transcript levels in the root meristems and senesced nodules. We showed TOR promoter expression along the progressing infection thread and in the infected cells of mature nodules. Posttranscriptional gene silencing of TOR using RNA interference (RNAi) showed that this gene is involved in lateral root elongation and root cell organization and also alters the density, size, and number of root hairs. The suppression of TOR transcripts also affected infection thread progression and associated cortical cell divisions, resulting in a drastic reduction of nodule numbers. TOR-RNAi resulted in reduced reactive oxygen species accumulation and altered CyclinD1 and CyclinD3 expression, which are crucial factors for infection thread progression and nodule organogenesis. Enhanced expression of TOR-regulated ATG genes in TOR-RNAi roots suggested that TOR plays a role in the recognition of Rhizobium as a symbiont. Together, these data suggest that TOR plays a vital role in the establishment of root nodule symbiosis in the common bean. © 2016 American Society of Plant Biologists. All Rights Reserved.

  19. Use of Torness simulator as a design and commissioning tool

    Hamilton, J.; Hacking, D.

    1989-01-01

    Real-time replica control room simulators are now in general use for the training of nuclear power plant operators, and the almost universal trend towards accurate physics-based plant models and detailed operator interface has opened up interesting and valuable engineering applications. This paper discusses the use of the Torness AGR Simulator in its dual role of commissioning support tool and operator training facility. (author)

  20. Management of heatstroke in Malaysian pilgrims in Saudi Arabia.

    Merican, M I

    1989-09-01

    Heat stroke is hardly seen in Malaysia. However, it occurs commonly in Saudi Arabia during the Haj season. Many Malaysian pilgrims are affected every year and some die. Having faced this environmental hazard for eight years, the Malaysian Medical Mission, sent each year to look after our pilgrims, modified its treatment strategy in 1988 and successfully decreased the overall morbidity and mortality of affected patients without the use of sophisticated equipment. A brief account of the management of 17 cases seen in 1988 is given. Only one died following treatment. The rest recovered fully without any residual neurological deficit or other complications.

  1. The Idea of a University: Rethinking the Malaysian Context

    Wan, Chang Da; Sirat, Morshidi; Razak, Dzulkifli

    2015-01-01

    This article explores the idea of a university with a specific focus in the Malaysian context. We begin the article guided by these questions—“What is a university?” and “What are universities for?”—in examining the historical and conceptual development of universities. This is followed by asking a more specific question—“What are Malaysian universities for?”—in which we discussed the overarching roles of public and private universities in this developing country. Having examined the roles of...

  2. Malaysian diaspora strategies in a globalized Muslim market

    Fischer, Johan

    2015-01-01

    This paper explores Malaysia’s efforts to develop and dominate a global market in halal (literally, ‘lawful or ‘permitted’) commodities as a diaspora strategy and how Malaysian state institutions, entrepreneurs, restaurants and middle-class groups in London respond to and are affected...... and practise Malaysian diaspora strategies in the globalized market for halal products and services. This paper is based on ethnographic material from fieldwork among state institutions, entrepreneurs, restaurants and middle-class groups in Kuala Lumpur and London, namely participant observation...

  3. mTOR and the health benefits of exercise.

    Watson, Kurt; Baar, Keith

    2014-12-01

    Exercise is the greatest physiological stress that our bodies experience. For example, during maximal endurance exercise in elite athlete's cardiac output can increase up to 8-fold and the working muscles receive 21-times more blood each minute than at rest. Given the physiological stress associated with exercise and the adaptations that occur to handle this stress, it is not surprising that exercise training is known to prevent or effectively treat a multitude of degenerative conditions including cardiovascular disease, cancer, diabetes, depression, Alzheimer's disease, Parkinson's disease, and many others. Many of the health benefits of exercise are mediated by the mammalian/mechanistic target of rapamycin (mTOR), either in complex 1 or 2, not only within the working muscle, but also in distant tissues such as fat, liver, and brain. This review will discuss how exercise activates mTOR in diverse tissues and the ways that mTOR is important in the adaptive response that makes us bigger, stronger, and healthier as a result of exercise. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Optimizing Managed Aquifer Recharge (MAR) Systems for Removal of Trace Organic Chemicals (TOrCs)

    Alidina, Mazahirali

    2014-06-01

    Managed aquifer recharge (MAR) is a low-energy subsurface water treatment system with the potential of being an important component of sustainable water reuse schemes. Alongside common wastewater contaminants, MAR systems have been shown to attenuate a range of trace organic chemicals (TOrCs). Despite several factors being possibly important for TOrC attenuation, many have not been investigated in depth. This research effort investigated three factors affecting attenuation of the moderately degradable TOrCs: primary substrate, adaptation of the microbial community to presence of TOrCs, and groundwater temperature. The overall goal was to optimize TOrC attenuation using different MAR configurations considering how these factors affect TOrC attenuation. The primary substrate composition and concentration significantly impacted attenuation of the moderately degradable TOrCs. Lower primary substrate concentrations and more refractory carbon generally resulted in better TOrC transformation, a more diverse microbial community in the infiltration zone and more diverse capabilities for TOrC degradation. The enzyme group cytochrome P450 may be important for TOrC transformation since its genes were more abundant under carbon-starving primary substrate conditions. Adaptation of the microbial community by pre-exposure to TOrCs was not required in order to degrade them. However, adaptation to the primary substrate was necessary for TOrC biotransformation due to its effect on the microbial community. Attenuation of most TOrCs was unaffected by changes in temperature. Some moderately degradable TOrCs, however, were better attenuated at higher temperatures likely due to increased microbial activity. Others were better degraded at lower temperatures likely due to favorable sorption conditions. In the context of applying MAR systems to potential water reuse schemes within Saudi Arabia, a reconnaissance study of TOrC occurrence in treated wastewater effluents was undertaken. Most of

  5. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.

    Kevin Bray

    Full Text Available mTOR inhibitors are used clinically to treat renal cancer but are not curative. Here we show that autophagy is a resistance mechanism of human renal cell carcinoma (RCC cell lines to mTOR inhibitors. RCC cell lines have high basal autophagy that is required for survival to mTOR inhibition. In RCC4 cells, inhibition of mTOR with CCI-779 stimulates autophagy and eliminates RIP kinases (RIPKs and this is blocked by autophagy inhibition, which induces RIPK- and ROS-dependent necroptosis in vitro and suppresses xenograft growth. Autophagy of mitochondria is required for cell survival since mTOR inhibition turns off Nrf2 antioxidant defense. Thus, coordinate mTOR and autophagy inhibition leads to an imbalance between ROS production and defense, causing necroptosis that may enhance cancer treatment efficacy.

  6. Hydrotherapy: An innovative treatment for obese Malaysians

    Noordin, M. Hazim M.; Ahmad, Hartini; Baharin, Shamsuddin

    2015-12-01

    Malaysia is ranked as a country with the most obese population in the Southeast Asia region, and placed sixth in the Asia Pacific. Obesity does not only influence the persons' mobility and quality of health, but could also link to medical leaves and absenteeism affecting the overall workforce productivity and efficiency. Routine physical activity is essential for good health and it is particularly important for those who are trying to lose weight or to maintain a healthy weight. However, it is disheartening to note that only 32.6 percent Malaysians above the age of 15 are involved in physical exercise or vigorous sports. There is an emergence of many types of hydrotherapy system, which are either active or passive and these can be at hospital settings, public places or in individual homes. Such hydrotherapy, if properly programmed can promote the physical activity amongst the obese in Malaysia. Current research on the use of active and passive hydrotherapy for obesity treatment was carried out. Subjects of both sexes and diverse age ranges, immersed themselves in a heated pool within hospital setting and in a bath tubs with high energy turbulent movement of medium temperature water. These hydrotherapy sessions provide a form of physical exercise in water as compared to on the land exercise. The findings of the hydrotherapy sessions have shown encouraging results. Quantitative data was analysed, with the help of descriptive statistics and paired sample t-test. Qualitative data was analysed manually with help of thematic analysis and specialised qualitative assessment software. This study reveals that hydrotherapy has improved patient's mobility, flexibility and exercise capability. Results reveal the reduction in the weight of subjects, with both quantitative and qualitative data results show that Hydrotherapy improved the quality of life in term of body pain reduction and general health improvement. Therefore, it can be concluded that the hydrotherapy can be seen

  7. Lifestyle Practices and Obesity in Malaysian Adolescents

    Pey Sze Teo

    2014-05-01

    Full Text Available Aim: To determine the influence of physical activity (PA and sedentary behavior (SB on obesity profiles of 454 Malaysian adolescents aged 12 to 19. Methods: Validated PA and SB questionnaires were used and body composition assessed using anthropometry and dual-energy X-ray absorptiometry (DXA. Results: Gender-specific multivariate analyses showed boys with high levels of total PA and moderate-to-vigorous physical activity (MVPA exhibited significantly lower levels of total body fat, percent body fat and android fat mass compared with low PA and MVPA groups, after adjusting for potential confounders. Girls with high SB levels showed significantly higher BMI, waist circumference and DXA-derived body fat indices than those at lower SB level. Multiple logistic analyses indicated that boys with low levels of total PA and MVPA had significantly greater obesity risk, 3.0 (OR 3.0; 95% CI, 1.1–8.1; p < 0.05 and 3.8-fold (OR 3.8; 95% CI, 1.4–10.1; p < 0.01, respectively, than more active boys. Only in girls with high SB level was there a significantly increased risk of obesity, 2.9 times higher than girls at low SP levels (OR 2.8; 95% CI, 1.0–7.5; p < 0.05.  Conclusions: The present findings indicate that higher PA duration and intensity reduced body fat and obesity risk while high screen-based sedentary behaviors significantly adversely influenced body fat mass, particularly amongst girls when the PA level was low.

  8. Profiles of Deanship in Malaysian Public Universities

    Parmjit Singh

    2009-11-01

    Full Text Available Today institutions of higher learning all around the globe are undergoing rapid transformation as they compete to survive in the ever changing global demands as a result of globalisation and internationalization. In such a scenario, there is a critical demand for heads of schools and faculties in higher education to establish a strong academic reputation and become sense makers of their organizations. The roles of deans as academic leaders encompass areas such as research, academia and administration. Realizing deans as pillars of academic scholarship, this study investigated the academic and scholarly leadership profiles of deans in Malaysian public universities. The study involved 348 randomly selected deans and senior academic administrative staff from nine public universities. Data was collected via questionnaire and semi structured interviews. The findings indicated that a majority of the respondents agreed that deans should have a good academic standing and research profile possessing at least a PhD. to act as a role model for the faculty staff. Besides that respondents indicated that research and publication should be one of the most important criteria in the selection of a dean. Results indicated that on the average, deans in Malaysia conducted at least one research project and wrote approximately 1.67 papers per year. Deans also highlighted that as academic leaders they had insufficient time to pursue their academic scholarship due to increased administrative duties; hence, they found it difficult to balance their leadership and scholarship responsibilities. More importantly this study indicated that deans as academic leaders left much to be desired.

  9. Influences on Malaysian Pharmacy Students' Career Preferences

    Kwai Chong, David Weng; Ahmadi, Keivan; Se, Wong Pei; Hassali, Mohammed Azmi; Hata, Ernieda Mohammed; Hadi, Muhammed Abdul; Sridhar, Sathvik Belagodu; Ahmed, Syed Imran; Yean, Low Bee; Efendie, Benny

    2010-01-01

    Objectives To identify and evaluate factors affecting the career preferences of fourth-year bachelor of pharmacy (BPharm) students in Malaysia in the presence of a 4-year period of mandatory government service. Methods A validated self-administered questionnaire was used in this cross-sectional study to collect data from final-year BPharm students enrolled at 3 government-funded universities and 1 private university in Malaysia. Both descriptive and inferential statistics were used for data analysis. Results Three hundred fourteen students responded (213 from public universities and 101 from the private university). Approximately 32% of public university students and 37% of private university students ranked their own interest in pharmacy as the reason for undertaking pharmacy degree studies; 40.4% of public and 19.8% of private university respondents stated that they would enter a nonpharmacy-related career upon graduation if given the choice. Public university students ranked hospital pharmacy as their choice of first career setting (4.39, p = 0.001), while private students ranked community pharmacy first (4.1, p = 0.002). On a scale of 1 to 5, salary received the highest mean score (3.9 and 4.0, p = 0.854) as the extrinsic factor most influencing their career choice. Conclusions Final-year students at Malaysian public universities were most interested in hospital pharmacy practice as their first career step upon graduation, while private university students were most interested in community pharmacy. The top 3 extrinsic factors rated as significant in selecting a career destination were salary, benefits, and geographical location. PMID:21301600

  10. Plasticity and mTOR: Towards Restoration of Impaired Synaptic Plasticity in mTOR-Related Neurogenetic Disorders

    Tanjala T. Gipson

    2012-01-01

    Full Text Available Objective. To review the recent literature on the clinical features, genetic mutations, neurobiology associated with dysregulation of mTOR (mammalian target of rapamycin, and clinical trials for tuberous sclerosis complex (TSC, neurofibromatosis-1 (NF1 and fragile X syndrome (FXS, and phosphatase and tensin homolog hamartoma syndromes (PTHS, which are neurogenetic disorders associated with abnormalities in synaptic plasticity and mTOR signaling. Methods. Pubmed and Clinicaltrials.gov were searched using specific search strategies. Results/Conclusions. Although traditionally thought of as irreversible disorders, significant scientific progress has been made in both humans and preclinical models to understand how pathologic features of these neurogenetic disorders can be reduced or reversed. This paper revealed significant similarities among the conditions. Not only do they share features of impaired synaptic plasticity and dysregulation of mTOR, but they also share clinical features—autism, intellectual disability, cutaneous lesions, and tumors. Although scientific advances towards discovery of effective treatment in some disorders have outpaced others, progress in understanding the signaling pathways that connect the entire group indicates that the lesser known disorders will become treatable as well.

  11. An Enhancing Security Research of Tor Anonymous Communication to Against DDos Attacks

    Feng Tao; Zhao Ming-Tao

    2017-01-01

    Tor (The Second Onion Router) is modified by the first generation onion router and known as the most prevalent anonymous communication system. According to the advantage of low latency, high confidentiality of transmission content, high security of communication channels and et al., Tor is widely used in anonymous Web browsing, instant message and so on. However, the vulnerability and blemish of Tor affect system security. An identity and Signcryption-based concurrent signature scheme was use...

  12. Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling

    Viktor Scheidt

    2014-11-01

    Full Text Available Previous work in yeast has suggested that modification of tRNAs, in particular uridine bases in the anticodon wobble position (U34, is linked to TOR (target of rapamycin signaling. Hence, U34 modification mutants were found to be hypersensitive to TOR inhibition by rapamycin. To study whether this involves inappropriate TOR signaling, we examined interaction between mutations in TOR pathway genes (tip41∆, sap190∆, ppm1∆, rrd1∆ and U34 modification defects (elp3∆, kti12∆, urm1∆, ncs2∆ and found the rapamycin hypersensitivity in the latter is epistatic to drug resistance of the former. Epistasis, however, is abolished in tandem with a gln3∆ deletion, which inactivates transcription factor Gln3 required for TOR-sensitive activation of NCR (nitrogen catabolite repression genes. In line with nuclear import of Gln3 being under control of TOR and dephosphorylation by the Sit4 phosphatase, we identify novel TOR-sensitive sit4 mutations that confer rapamycin resistance and importantly, mislocalise Gln3 when TOR is inhibited. This is similar to gln3∆ cells, which abolish the rapamycin hypersensitivity of U34 modification mutants, and suggests TOR deregulation due to tRNA undermodification operates through Gln3. In line with this, loss of U34 modifications (elp3∆, urm1∆ enhances nuclear import of and NCR gene activation (MEP2, GAP1 by Gln3 when TOR activity is low. Strikingly, this stimulatory effect onto Gln3 is suppressed by overexpression of tRNAs that usually carry the U34 modifications. Collectively, our data suggest that proper TOR signaling requires intact tRNA modifications and that loss of U34 modifications impinges on the TOR-sensitive NCR branch via Gln3 misregulation.

  13. Rapamycin and Glucose-Target of Rapamycin (TOR) Protein Signaling in Plants*

    Xiong, Yan; Sheen, Jen

    2012-01-01

    Target of rapamycin (TOR) kinase is an evolutionarily conserved master regulator that integrates energy, nutrients, growth factors, and stress signals to promote survival and growth in all eukaryotes. The reported land plant resistance to rapamycin and the embryo lethality of the Arabidopsis tor mutants have hindered functional dissection of TOR signaling in plants. We developed sensitive cellular and seedling assays to monitor endogenous Arabidopsis TOR activity based on its conserved S6 kinase (S6K) phosphorylation. Surprisingly, rapamycin effectively inhibits Arabidopsis TOR-S6K1 signaling and retards glucose-mediated root and leaf growth, mimicking estradiol-inducible tor mutants. Rapamycin inhibition is relieved in transgenic plants deficient in Arabidopsis FK506-binding protein 12 (FKP12), whereas FKP12 overexpression dramatically enhances rapamycin sensitivity. The role of Arabidopsis FKP12 is highly specific as overexpression of seven closely related FKP proteins fails to increase rapamycin sensitivity. Rapamycin exerts TOR inhibition by inducing direct interaction between the TOR-FRB (FKP-rapamycin binding) domain and FKP12 in plant cells. We suggest that variable endogenous FKP12 protein levels may underlie the molecular explanation for longstanding enigmatic observations on inconsistent rapamycin resistance in plants and in various mammalian cell lines or diverse animal cell types. Integrative analyses with rapamycin and conditional tor and fkp12 mutants also reveal a central role of glucose-TOR signaling in root hair formation. Our studies demonstrate the power of chemical genetic approaches in the discovery of previously unknown and pivotal functions of glucose-TOR signaling in governing the growth of cotyledons, true leaves, petioles, and primary and secondary roots and root hairs. PMID:22134914

  14. Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling.

    Scheidt, Viktor; Jüdes, André; Bär, Christian; Klassen, Roland; Schaffrath, Raffael

    2014-11-29

    Previous work in yeast has suggested that modification of tRNAs, in particular uridine bases in the anticodon wobble position (U34), is linked to TOR (target of rapamycin) signaling. Hence, U34 modification mutants were found to be hypersensitive to TOR inhibition by rapamycin. To study whether this involves inappropriate TOR signaling, we examined interaction between mutations in TOR pathway genes ( tip41 ∆, sap190 ∆, ppm1 ∆, rrd1 ∆) and U34 modification defects ( elp3 ∆, kti 12∆, urm1 ∆, ncs2 ∆) and found the rapamycin hypersensitivity in the latter is epistatic to drug resistance of the former. Epistasis, however, is abolished in tandem with a gln3 ∆ deletion, which inactivates transcription factor Gln3 required for TOR-sensitive activation of NCR (nitrogen catabolite repression) genes. In line with nuclear import of Gln3 being under control of TOR and dephosphorylation by the Sit4 phosphatase, we identify novel TOR-sensitive sit4 mutations that confer rapamycin resistance and importantly, mislocalise Gln3 when TOR is inhibited. This is similar to gln3 ∆ cells, which abolish the rapamycin hypersensitivity of U34 modification mutants, and suggests TOR deregulation due to tRNA undermodification operates through Gln3. In line with this, loss of U34 modifications ( elp3 ∆, urm1 ∆) enhances nuclear import of and NCR gene activation ( MEP2 , GAP1 ) by Gln3 when TOR activity is low. Strikingly, this stimulatory effect onto Gln3 is suppressed by overexpression of tRNAs that usually carry the U34 modifications. Collectively, our data suggest that proper TOR signaling requires intact tRNA modifications and that loss of U34 modifications impinges on the TOR-sensitive NCR branch via Gln3 misregulation.

  15. The role of mTOR in ovarian cancer, polycystic ovary syndrome and ovarian aging.

    Liu, Jin; Wu, Dai-Chao; Qu, Li-Hua; Liao, Hong-Qing; Li, Mei-Xiang

    2018-05-12

    The mammalian target of rapamycin, mTOR, is a serine-threonine protein kinase downstream of the phosphatidylinositol 3-kinase (PI3K)-AKT axis. The pathway can regulate cell growth, proliferation, and survival by activating ribosomal kinases. Recent studies have implicated the mTOR signaling pathway in ovarian neoplasms, polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Preclinical investigations have demonstrated that the PI3K/AKT/mTOR pathway is frequently activated in the control of various ovarian functions. mTOR allows cancer cells to escape the normal biochemical system and regulates the balance between apoptosis and survival. Some recent studies have suggested that involvement of the mTOR signaling system is an important pathophysiological basis of PCOS. Overexpression of the mTOR pathway can impair the interaction of cumulus cells, lead to insulin resistance, and affect the growth of follicles directly. The roles of mTOR signaling in follicular development have been extensively studied in recent years; abnormalities in this process lead to a series of pathologies such as POF and infertility. To improve understanding of the role of the mTOR signaling pathway in the pathogenesis and development of ovarian diseases, here we review the roles of mTOR signaling in such diseases and discuss the corresponding therapeutic strategies that target this pathway. This article is protected by copyright. All rights reserved. © 2018 Wiley Periodicals, Inc.

  16. An Enhancing Security Research of Tor Anonymous Communication to Against DDos Attacks

    Feng Tao

    2017-01-01

    Full Text Available Tor (The Second Onion Router is modified by the first generation onion router and known as the most prevalent anonymous communication system. According to the advantage of low latency, high confidentiality of transmission content, high security of communication channels and et al., Tor is widely used in anonymous Web browsing, instant message and so on. However, the vulnerability and blemish of Tor affect system security. An identity and Signcryption-based concurrent signature scheme was used to prevent the behaviors of attackers from inserting controlled nodes and conspiring to make DDos attacks. The integrated security of Tor system was enhanced in our scheme. In addition we have proved the scheme.

  17. Proof-of-Work as Anonymous Micropayment: Rewarding a Tor Relay

    Biryukov, Alex; Pustogarov, Ivan

    2015-01-01

    In this paper we propose a new micropayments scheme which can be used to reward Tor relay operators. Tor clients do not pay Tor relays with electronic cash directly but submit proof of work shares which the relays can resubmit to a crypto-currency mining pool. Relays credit users who submit shares with tickets that can later be used to purchase improved service. Both shares and tickets when sent over Tor circuits are anonymous. The analysis of the crypto-currencies market prices shows that th...

  18. Determination and validation of mTOR kinase-domain 3D structure by homology modeling

    Lakhlili W

    2015-07-01

    Full Text Available Wiame Lakhlili,1 Gwénaël Chevé,2 Abdelaziz Yasri,2 Azeddine Ibrahimi1 1Laboratoire de Biotechnologie (MedBiotech, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V de Rabat, Rabat, Morroco; 2OriBase Pharma, Cap Gamma, Parc Euromédecine, Montpellier, France Abstract: The AKT/mammalian target of rapamycin (mTOR pathway is considered as one of the commonly activated and deregulated signaling pathways in human cancer. mTOR is associated with other proteins in two molecular complexes: mTOR complex 1/Raptor and the mTOR complex 2/Rictor. Using the crystal structure of the related lipid kinase PI3Kγ, we built a model of the catalytic region of mTOR. The modeling of the three-dimensional (3D structure of the mTOR was performed by homology modeling program SWISS-MODEL. The quality and validation of the obtained model were performed using PROCHECK and PROVE softwares. The overall stereochemical property of the protein was assessed by the Ramachandran plot. The model validation was also done by docking of known inhibitors. In this paper, we describe and validate a 3D model for the mTOR catalytic site.Keywords: mTOR, homology modeling, mTOR kinase-domain, docking

  19. Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration

    Montes, Daniela K.; Brenet, Marianne; Muñoz, Vanessa C.; Burgos, Patricia V.; Villanueva, Carolina I. [Department of Physiology, Universidad Austral de Chile, Valdivia 509-9200 (Chile); Figueroa, Carlos D. [Department of Anatomy, Histology and Pathology, Universidad Austral de Chile, Valdivia 509-9200 (Chile); González, Carlos B., E-mail: cbgonzal@uach.cl [Department of Physiology, Universidad Austral de Chile, Valdivia 509-9200 (Chile); Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 (United States)

    2013-11-29

    Highlights: •AVP induces mTOR phosphorylation in A-10 cells cultured in high glucose concentration. •The mTOR phosphorylation is mediated by the PI3K/Akt pathway activation. •The AVP-induced mTOR phosphorylation inhibited autophagy and stimulated cell proliferation. -- Abstract: Mammalian target of rapamycin (mTOR) complex is a key regulator of autophagy, cell growth and proliferation. Here, we studied the effects of arginine vasopressin (AVP) on mTOR activation in vascular smooth muscle cells cultured in high glucose concentration. AVP induced the mTOR phosphorylation in A-10 cells grown in high glucose, in contrast to cells cultured in normal glucose; wherein, only basal phosphorylation was observed. The AVP-induced mTOR phosphorylation was inhibited by a PI3K inhibitor. Moreover, the AVP-induced mTOR activation inhibited autophagy and increased thymidine incorporation in cells grown in high glucose. This increase was abolished by rapamycin which inhibits the mTORC1 complex formation. Our results suggest that AVP stimulates mTOR phosphorylation by activating the PI3K/Akt signaling pathway and, subsequently, inhibits autophagy and raises cell proliferation in A-10 cells maintained in high glucose concentration.

  20. Analysis of volatile compounds of Malaysian Tualang ( Koompassia ...

    Analysis of volatile compounds of Malaysian Tualang ( Koompassia excelsa ) honey using gas chromatography mass spectrometry. ... Other classes of chemical compounds detected included acids, aldehydes, alcohols, ketones, terpenes, furans and a miscellaneous group. Methanol yielded the highest number of extracted ...

  1. Distribution of Articles in Written Composition among Malaysian ESL Learners

    Rahim, Mia Emily Abdul; Rahim, Emma Marini Abdul; Ning, Chia Han

    2013-01-01

    The study aimed to investigate the distribution patterns of the English grammar articles (a, an, and the) as well as the distributions of their colligation patterns in written compositions of English among Malaysian ESL learners. This paper reports the results of a corpus-based study on articles used by these learners. The method used in this…

  2. Factors Affecting School Choice: What Do Malaysian Chinese Parents Want?

    Siah, Poh Chua; Christina Ong, Sook Beng; Tan, Swee Mee; Sim, Chzia Poaw; Xian Thoo, Raphael Yi

    2018-01-01

    Aiming to explore factors affecting Malaysian Chinese parents in sending their children to either national secondary schools or Chinese independent schools, 494 parents were surveyed using a questionnaire. Results showed that parents who sent their children to Chinese independent schools have different priorities compared to those who sent theirs…

  3. Predictors of Academics' Career Advancement at Malaysian Private Universities

    Arokiasamy, Lawrence; Ismail, Maimunah; Ahmad, Aminah; Othman, Jamilah

    2011-01-01

    Purpose: This paper aims to examine the influence of individual and organizational variables on the career advancement of academics in Malaysian private universities. Design/methodology/approach: A correlation study was conducted in six private universities. Data were collected using a structured self-administered questionnaire. The dependent…

  4. Malaysian Education Index (MEI): An Online Indexing and Repository System

    Kabilan, Muhammad Kamarul; Ismail, Hairul Nizam; Yaakub, Rohizani; Yusof, Najeemah Mohd; Idros, Sharifah Noraidah Syed; Umar, Irfan Naufal; Arshad, Muhammad Rafie Mohd.; Idrus, Rosnah; Rahman, Habsah Abdul

    2010-01-01

    This "Project Sheet" describes an on-going project that is being carried out by a group of educational researchers, computer science researchers and librarians from Universiti Sains Malaysia, Penang. The Malaysian Education Index (MEI) has two main functions--(1) Online Indexing System, and (2) Online Repository System. In this brief…

  5. Readiness towards Entrepreneurship Education: Students and Malaysian Universities

    Othman, Norasmah; Hashim, Norashidah; Wahid, Hariyaty Ab

    2012-01-01

    Purpose: The purpose of this paper is to observe the readiness of students and the internal environment of Malaysian public universities in the implementation of entrepreneurship education. Design/methodology/approach: The authors employed a quantitative approach and the main instrument used to gauge the entrepreneurship readiness among students…

  6. Florae Malesianae Precursores IX. New Malaysian Species of Fimbristylis

    Ohwi, J.

    1955-01-01

    — During the last World War Dr Ohwi worked for several years in the Herbarium Bogoriense and compiled a preliminary revision of the Malaysian representatives of the genus Fimbristylis. The absence of any world revision, the temporary inaccessibility of type material, and of adequate literature, were

  7. Small Angle Neutron Scattering instrument at Malaysian TRIGA reactor

    Mohd, Shukri; Kassim, Razali; Mahmood, Zal Uyun [Malaysian Inst. for Nuclear Technology Research (MINT), Bangi, Kajang (Malaysia); Radiman, Shahidan

    1998-10-01

    The TRIGA MARK II Research reactor at the Malaysian Institute for Nuclear Research (MINT) was commissioned in July 1982. Since then various works have been performed to utilise the neutrons produced from this steady state reactor. One of the project involved the Small Angle Neutron Scattering (SANS). (author)

  8. Quality of Life of Older Malaysians Living Alone

    Yahaya, Nurizan; Abdullah, Siti Suhailah; Momtaz, Yadollah Abolfathi; Hamid, Tengku Aizan

    2010-01-01

    According to the 2000 census report, about 7% of the 1.4 million people 60 years and over in Malaysia live alone. This study investigated socioeconomic factors affecting the quality of life of this vulnerable population. Data from a subsample of the study on Mental Health and Quality of Life of Older Malaysians were used in this paper. About 10%…

  9. Malaysian Students in U.S. Colleges and Universities.

    Boyd, Alan W., Ed.; Noss, Elaine M., Ed.

    This publication is a response to the need for better understanding of the Malaysian student population studying U.S. institutions of higher education. Part 1 is an introduction to Malaysia, with two articles giving background information. The first is a history of Malaysia and the development of its education system, by Fatimah Hamid-Don of Ohio…

  10. The Significance of Malaysian Real Estate Research Agenda

    Muhammad Najib Razali

    2011-12-01

    Full Text Available This paper investigates research agenda by the Malaysian real estate researchers (MRERs. This study adopts a deskwork approach by examining research papers published in leading real estate journals, both international and local and papers presented in main real estate conferences from 1997 to 2010. In addition, the number of research papers published and presented were also assessed from several main real estate research journals in the US, UK, Asia/Australia and Malaysia and conferences such as American Real Estate Society (ARES, European Real Estate Society (ERES, Pacific Rim Real Estate Society (PRRES, Asian Real Estate Society (AsRES and local conference; International Real Estate Research Symposium (IRERS. The study indicates that the Malaysian real estate researchers (MRERs have made a positive contribution to the global real estate research. Nevertheless, there is still more effort needed in order to compete in the global real estate research agenda. It is anticipated that this trend will change since the Malaysian government has emphasised on improving the quality of higher learning institutions' for which research and publication will be the main agenda. The contribution from MRERs will significantly improve Malaysian universities standing in global ranking.

  11. Sociolinguistic Competence and Malaysian Students' English Language Proficiency

    Muniandy, Mohan K.; Nair, Gopala Krishnan Sekharan; Shanmugam, Shashi Kumar Krishnan; Ahmad, Irma; Noor, Norashikin Binte Mohamed

    2010-01-01

    This paper aims to highlight the importance of teaching sociolinguistic competence to ESL learners in Malaysian schools. Sociolinguistic competence is the knowledge of socio cultural rules of language and of discourse. This type of competence requires an understanding of the socio context in which language is used. It is proposed that carefully…

  12. General Adjustment Influence Factor of Malaysian Construction Expatriates Executives Abroad

    Zainol Halmi

    2016-01-01

    Full Text Available The success of Malaysian construction companies creates an opportunity to explore abroad. Past studies have shown that the difficulty of expatriates in adjusting to a new environment is the main aspect that leads to failure of assignments. The success in implementing an overseas assignment does not solely depend on an expatriate’s technical expertise. The adjustment issues such as the interaction with the host nationals, and adaptability to the host country’s culture also exert influence on the assignment. The research was conducted to identify the influence of executive expatriate general adjustment on assignment in host countries. The objective of the study was to identify adjustment influence factors relating to general adjustment abroad. Questionnaires were sent to Malaysian expatriate executives. Sixty four Malaysian expatriate executives from Malaysian construction companies overseas were involved in this study. The findings show interaction, social and living environment influences their adjustment during expatriation. Pre-departure training preparation aspects for expatriates is a good step before their departure to host countries.

  13. Investigation of Malaysian Higher Education Quality Culture and Workforce Performance

    Ali, Hairuddin Mohd; Musah, Mohammed Borhandden

    2012-01-01

    Purpose: The purpose of this study is to examine the relationship between the quality culture and workforce performance in the Malaysian higher education sector. The study also aims to test and validate the psychometric properties of the quality culture and workforce performance instruments used in the study. Design/methodology/approach: A total…

  14. Exploring the clean development mechanism: Malaysian case study

    Pedersen, Anne Rathmann

    2008-01-01

    During 2006 the CDM market in Malaysia became established and by December 2007 a total of 20 Malaysian projects had registered with the CDM Executive Board. The Kyoto Protocol defines the Annex I countries, as countries that are obliged to reduce their greenhouse gas (GHG) emissions and the clean...

  15. Malaysian growth centiles for children under six years old.

    Bong, Yiibonn; Shariff, Asma Ahmad; Mohamed, Abdul Majid; Merican, Amir Feisal

    2015-03-01

    Growth references are useful for the screening, assessment and monitoring of individual children as well as for evaluating various growth promoting interventions that could possibly affect a child in early life. To determine the growth centiles of Malaysian children and to establish contemporary cross-sectional growth reference charts for height and weight from birth to 6 years of age based on a representative sample of children from Malaysia. Gender- and age-specific centile curves for height and weight were derived using the Cole's LMS method. Data for this study were retrieved from Malaysian government health clinics using a two-stage stratified random sampling technique. Assessment of nutritional status was done with the SD scores (Z-scores) of WHO 2006 standards. Boys were found to be taller and heavier than girls in this study. The median length of Malaysian children was higher than the WHO 2006 standards and CDC 2000 reference. The overall prevalence of stunting and underweight were 8.3% and 9.3%, respectively. This study presents the first large-scale initiative for local reference charts. The growth reference would enable the growth assessment of a Malaysian child compared to the average growth of children in the country. It is suggested that the use of WHO 2006 Child Growth Standards should be complemented with local reference charts for a more wholesome growth assessment.

  16. Collaborative and Cooperative Learning in Malaysian Mathematics Education

    Hossain, Md. Anowar; Tarmizi, Rohani Ahmad; Ayud, Ahmad Fauzi Mohd

    2012-01-01

    Collaborative and cooperative learning studies are well recognized in Malaysian mathematics education research. Cooperative learning is used to serve various ability students taking into consideration of their level of understanding, learning styles, sociological backgrounds that develop students' academic achievement and skills, and breeze the…

  17. Malaysian Private Education Quality: Application of SERVQUAL Model

    Vaz, Anthony; Mansori, Shaheen

    2013-01-01

    Intense competition among existing private education providers and the Malaysian government's relaxation of regulations for allowing international universities to open off shore campuses in Malaysia, have forced companies in the education industry to develop strategies which can help them to make their existing students satisfied and keep them…

  18. Modeling Environmental Literacy of Malaysian Pre-University Students

    Shamuganathan, Sheila; Karpudewan, Mageswary

    2015-01-01

    In this study attempt was made to model the environmental literacy of Malaysian pre-university students enrolled in a matriculation college. Students enrolled in the matriculation colleges in Malaysia are the top notch students in the country. Environmental literacy of this group is perceived important because in the future these students will be…

  19. Validity of selected cardiovascular field-based test among Malaysian ...

    Based on emerge obese problem among Malaysian, this research is formulated to validate published tests among healthy female adult. Selected test namely; 20 meter multi-stage shuttle run, 2.4km run test, 1 mile walk test and Harvard Step test were correlated with laboratory test (Bruce protocol) to find the criterion validity ...

  20. Malaysian University Students' Attitudes to Academic Dishonesty and Business Ethics

    Ahmad, Zauwiyah; Simun, Maimun; Mohammad, Junaini

    2008-01-01

    Academic dishonesty is believed to have predictive ability for subsequent behaviours in the workplace. This study adds to the literature by investigating Malaysian business students' attitudes to academic dishonesty and their attitudes to ethics issues in business. This study also explores the association between these two constructs. The form of…

  1. Short history of the Phytography of Malaysian vascular plants

    Wit, de H.C.D.

    1948-01-01

    For various reasons the space occupied by pre-Linnean Malaysian phytography in this concise history seems too large and out of proportion in comparison to the survey of post-Linnean work. Modern plant description, though based on, and derived from, ancient beginnings and traditions, maintains but

  2. Malaysian traditional medicine: the usage of marine resources as a ...

    indicate that some of the marine resources are used as a food as well as to treat heart disease. Finally, the findings of this study will help demystify traditional medical practices in Malaysia and assist academicians in understanding the Malaysian culture of traditional medicine. Keywords: Marine resources; heart disease; ...

  3. MALAYSIAN WEATHER DATA (TRY) FOR ENERGY SIMULATIONS IN BUILDINGS

    Reimann, Gregers Peter

    2001-01-01

    Detailed energy simulations for buildings in Malaysia have become possible after the recent construction of a Malaysian TRY (Test Reference Year) based on 21 years of hourly weather data from Subang Meteorological Station. The climatic parameters contained in the TRY are dry bulb temperature, wet...

  4. Students' Entrepreneurial Inclination at a Malaysian Polytechnic: A Preliminary Investigation

    Yasin, Ahmad Yasruddin Md; Mahmood, Nik Abdul Aziz Nik; Jaafar, Nik Azyyati Nik

    2011-01-01

    This paper reports preliminary results of an ongoing project to examine students' inclination towards entrepreneurship at a Malaysian polytechnic. The study used a self-administered questionnaire to explore the influence of entrepreneurial intent, perceived behavioral control, self-efficacy, perceived barriers, perceived support factors and…

  5. Transforming Sustainability Development Education in Malaysian Schools through Greening Activities

    Hanifah, Mahat; Shaharudin, Idrus; Mohmadisa, Hashim; Nasir, Nayan; Yazid, Saleh

    2015-01-01

    This article aims to evaluate the practice of sustainability among Malaysian Secondary Schools involved in the Sustainable Schools Program Environmental Award (SLAAS). The research attempts to identify the SLAAS effects on teachers' and students' behaviors after direct involvement with the activities of the program. The cluster sampling technique…

  6. Public acceptance of nuclear power among Malaysian students

    Muhamad Pauzi, Anas; Saad, Juniza Md; Arif Abu Bakar, Asyraf; Hannan Damahuri, Abdul; Syukri, Nur Syamim Mohd

    2018-01-01

    Malaysian government’s aim to include nuclear energy for electricity generation has triggered various reactions from all especially the public. The objective of this study is to have a better understanding on the knowledge, sources of information of nuclear power and sources of energy chosen by Malaysian in 20 years’ time. Besides that, we want to examine the level of acceptance and perception of Malaysian towards nuclear energy and we want to identify the correlation between public perceptions with the acceptance towards nuclear power in Malaysia, and also to study the differences between perception and acceptance of nuclear power with gender and educational level. For this research methodology, the research questions are given orally or through paper-pencil and also social networking site such as Facebook or through electronic media application such as WhatsApp and Google docs. The data were analysed using a SPSS version 22.0 (Statistical Package for the Social Sciences). Results showed that more than 50% of the respondents have the knowledge of nuclear energy. A part of from that, only 39 % are confident government can afford to build NPP in Malaysia and 41 % disagree nuclear energy is the best option for future energy. From analysis using SPSS 22 we estimate negative perception will give a negative acceptance in term of support towards the use of nuclear energy in power generation in Malaysia. There are also slight correlation that the higher the level of education of Malaysian, the more negative the perception of Malaysian in accepting nuclear energy as source of power in Malaysia. Therefore in shaping a positive acceptance of NPP in Malaysia, the authorities need to educate the people with the knowledge of nuclear in order to overcome the negative perception towards nuclear power.

  7. Belongingness in the workplace: a study of Malaysian nurses' experiences.

    Mohamed, Z; Newton, J M; McKenna, L

    2014-03-01

    The need to belong has been proposed as the most basic need for human psychological well-being. Lack of belongingness has been associated with stress, anxiety and lack of esteem. Social and psychological functioning in the workplace has been linked to nurses' interconnection with others and their perceptions of belongingness. To explore factors contributing to Malaysian nurses' sense of belonging in the workplace. A descriptive questionnaire survey of registered nurses (n = 437) working in two Malaysian hospitals was conducted in 2011. Previously validated questionnaires translated into the Malay language were used. Data were analysed using SPSS 19.0. Nurses enhanced their sense of belonging through acceptance, 'fitting in', respect and group harmony. There were no specific demographic factors contributing to the nurses' perceptions. The findings suggest that these priorities for belongingness were contextually influenced by factors such as elements of Malaysian culture, the nature of nurses' teamwork and stereotypical values on the nursing profession. Data were collected in only two hospitals. Experiences of nurses in other hospitals and areas of Malaysia may not be similar. The influence of Malaysian culture in this study raises issues about utilization of a measurement scale developed in Western cultures, which may not directly accord with cultural values of an Eastern ethnicity. Aspects of belongingness in Malaysian nurses reflect those of nurses elsewhere. However, there are specific cultural influences at play. Therefore, development of a measurement scale based on Eastern culture would help in increasing understanding of workplace practices among these groups. Workplaces that perpetuate an environment that is not conducive to generating a sense of belonging may have an untoward impact on care delivery. Healthcare policies need to ensure patient care has a focus on engaging practitioners within multidisciplinary teams. © 2013 International Council of

  8. MOOD AND PERFORMANCE IN YOUNG MALAYSIAN KARATEKA

    Rebecca S. K. Wong

    2006-07-01

    Full Text Available In an attempt to test the conceptual model by Lane and Terry, the purposes of this study were 1 to assess mood states in non-depressed and depressed young karate athletes; 2 to assess mood states in relation to performance in young karate athletes. The participants were recruited from the 2004 Malaysian Games (72 males, 19.20 ± 1.16 years; 37 females, 18.78 ± 0.88 years. The athletes were divided into winners (medalists and losers. The Brunel Mood Scale (BRUMS was administered prior to the start of competition. MANOVA was employed to treat the data, while Pearson correlations were calculated for mood states in each depressed mood group and by gender. In terms of non-depressed and depressed mood, tension in the females was higher in the depressed group (5.61 ± 3.02 vs. 3.11 ± 1.90, p = 0.026, eta2 = 0.133, as was fatigue (3.64 ± 2.61 vs. 0.89 ± 1.69, p = 0.006, eta2 = 0.199. Tension in the males was higher in the depressed group (4.41 ± 2.52 vs. 1.50 ± 1.55, p < 0.001, eta2 = 0.215, as was anger (1.43 ± 1.88 vs. 0.25 ± 1.00, p = 0.019, eta2 = 0.076. The highest associations among mood subscales were between anger and depression (r = 0.57, and between depression and fatigue ( r = 0.55 in depressed males. The female winning karateka scored higher on anger (3.08 ± 2.96 vs. 1.29 ± 2.24, p = 0.046, eta2 = 0.109. The highest correlations between mood dimensions in depressed females were between depression and anger (r = 0.85 and between depression and confusion (r = 0.85. Contrary to previous research on the influence of depression on anger, only the female winners scored higher on anger. Several negative mood dimensions were higher in both male and female depressed groups, lending some support to the conceptual model advanced by Lane and Terry

  9. The geomorphic impact of glaciers as indicated by tors in North Sweden (Aurivaara, 68° N)

    André, Marie-Françoise

    2004-02-01

    Geomorphological investigations carried out on 15 tor-like features located on the Aurivaara plateau (North Sweden, 68° N) provide new insights in the greatly debated age of these landforms. Erratics and till trapped deep in the tor joints support a pre-Weichselian age for tor formation. Moreover, the occurrence of various weathering stages in allochtonous material, the joint width up to 1.5 m (requiring long-term weathering), and the frequent association of tors with pediment-like forms, suggest pre-Quaternary tor formation. The juxtaposition of fresh erratics and in situ old weathering features (mushroom rocks, concentrically weathered well-rounded corestones, and grus) indicates a predominantly cold-based regime for the Scandinavian ice sheet, with erratics carried by the overlying moving ice being repeatedly deposited on tor summits during deglaciation phases. The relationships between tors and ice action indicated for the Aurivaara plateau result in the proposal of a morphodynamical succession of five tor subtypes ranging from the preservation of well-rounded corestones still embedded in grus (suggesting negligible glacial erosion) to the almost complete removal of tor features by ice scouring. A comparison with tors in similar geological and topographical contexts from the unglaciated Dartmoor area allows a tentative evaluation of an average overall glacial erosion of 0-10 m on the northern Sweden plateaus, in sharp contrast with the 190 m overdeepening of the nearby Torneträsk basin. Thus, this case study of Swedish tors provides additional support to the recent interpretations of relict landscapes in previously glaciated areas and is in accordance with the classical «model» of glacial selective erosion established in the Nordic and Arctic mountains.

  10. Dietary interventions that reduce mTOR activity rescue autistic-like behavioral deficits in mice.

    Wu, Jiangbo; de Theije, Caroline G M; da Silva, Sofia Lopes; Abbring, Suzanne; van der Horst, Hilma; Broersen, Laus M; Willemsen, Linette; Kas, Martien; Garssen, Johan; Kraneveld, Aletta D

    2017-01-01

    Enhanced mammalian target of rapamycin (mTOR) signaling in the brain has been implicated in the pathogenesis of autism spectrum disorder (ASD). Inhibition of the mTOR pathway improves behavior and neuropathology in mouse models of ASD containing mTOR-associated single gene mutations. The current study demonstrated that the amino acids histidine, lysine, threonine inhibited mTOR signaling and IgE-mediated mast cell activation, while the amino acids leucine, isoleucine, valine had no effect on mTOR signaling in BMMCs. Based on these results, we designed an mTOR-targeting amino acid diet (Active 1 diet) and assessed the effects of dietary interventions with the amino acid diet or a multi-nutrient supplementation diet (Active 2 diet) on autistic-like behavior and mTOR signaling in food allergic mice and in inbred BTBR T+Itpr3tf/J mice. Cow's milk allergic (CMA) or BTBR male mice were fed a Control, Active 1, or Active 2 diet for 7 consecutive weeks. CMA mice showed reduced social interaction and increased self-grooming behavior. Both diets reversed behavioral impairments and inhibited the mTOR activity in the prefrontal cortex and amygdala of CMA mice. In BTBR mice, only Active 1 diet reduced repetitive self-grooming behavior and attenuated the mTOR activity in the prefrontal and somatosensory cortices. The current results suggest that activated mTOR signaling pathway in the brain may be a convergent pathway in the pathogenesis of ASD bridging genetic background and environmental triggers (food allergy) and that mTOR over-activation could serve as a potential therapeutic target for the treatment of ASD. Copyright © 2016. Published by Elsevier Inc.

  11. Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1

    Park, In-Hyun; Erbay, Ebru; Nuzzi, Paul; Chen Jie

    2005-01-01

    The protein kinase mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and growth, with the ribosomal subunit S6 kinase 1 (S6K1) as one of the key downstream signaling effectors. A critical role of mTOR signaling in skeletal muscle differentiation has been identified recently, and an unusual regulatory mechanism independent of mTOR kinase activity and S6K1 is revealed. An mTOR pathway has also been reported to regulate skeletal muscle hypertrophy, but the regulatory mechanism is not completely understood. Here, we report the investigation of mTOR's function in insulin growth factor I (IGF-I)-induced C2C12 myotube hypertrophy. Added at a later stage when rapamycin no longer had any effect on normal myocyte differentiation, rapamycin completely blocked myocyte hypertrophy as measured by myotube diameter. Importantly, a concerted increase of average myonuclei per myotube was observed in IGF-I-stimulated myotubes, which was also inhibited by rapamycin added at a time when it no longer affected normal differentiation. The mTOR protein level, its catalytic activity, its phosphorylation on Ser2448, and the activity of S6K1 were all found increased in IGF-I-stimulated myotubes compared to unstimulated myotubes. Using C2C12 cells stably expressing rapamycin-resistant forms of mTOR and S6K1, we provide genetic evidence for the requirement of mTOR and its downstream effector S6K1 in the regulation of myotube hypertrophy. Our results suggest distinct mTOR signaling mechanisms in different stages of skeletal muscle development: While mTOR regulates the initial myoblast differentiation in a kinase-independent and S6K1-independent manner, the hypertrophic function of mTOR requires its kinase activity and employs S6K1 as a downstream effector

  12. The Heysham 2 and Torness nuclear power station projects

    Cameron, P.J.

    1989-01-01

    At the beginning of the design of the Heysham 2 and Torness Nuclear Power Stations in the UK, it was agreed that the Hinkley Point B/Hunterston B Advanced Gas Cooled reactor design would be repeated. However, the Hinkley Point B/Hunterston B designs dated from 1964, and inevitably safety requirements had escalated in the intervening years. Furthermore, operating experience gained from Hinkley Point B/Hunterston B showed that it was desirable to make changes to particular features. Design changes were therefore included where it was considered essential to improve performance, to improve safety and to improve engineering. The resulting station designs are described. (author)

  13. Modifying the Heysham 2 and Torness guide tubes

    Salter, I.D.

    1988-01-01

    In 1986 the National Nuclear Corporation carried out the unfuelled engineering run on Torness Reactor One. Subsequent inspection revealed wear on the reactor control rods, following severe spinning caused by gas cross flow swirls at the guide tube castellated ring. The adopted solution was to machine 32 radial holes through the guide tube wall and blank off the existing castellated slots, however, man access to the guide tubes is extremely difficult. This paper describes how Taylor Hitec produced, in only 12 weeks, three remote drilling machines, together with associated debris collection systems, cleaning equipment and remote video/CCTV inspection systems, and then carried out the modifications to the reactors. (author)

  14. Perception of masculinity amongst young Malaysian men: a qualitative study of university students

    Fazli Khalaf, Zahra; Low, Wah Yun; Ghorbani, Behzad; Merghati Khoei, Effat

    2013-01-01

    Background Perception of Masculinity plays an important role in men?s lifestyles and health behaviors. Although, the importance of masculinity has been widely discussed in men?s health literature, very little is known about the meanings of masculinity in the Malaysian setting. This research aimed to explore the meanings of masculinity among Malaysian university men. Methods This qualitative study utilized in-depth interviews with 34 young Malaysian university men, aged 20?30?years from three ...

  15. Effects of Focus of Accounting Research on the Quality of Accounting Education in Malaysian Universities

    Kabiru Isa Dandago; Nor Azlina Binti Shaari

    2013-01-01

    This paper reviews the impact of focus of research in accounting on the quality of accounting education in Malaysian Universities. Research in accounting is very important in Malaysian Universities, in particular, and the Malaysian tertiary educational institutions, in general, and it is expected that academic research in accounting would improve the quality of accounting education in the country. The study is mainly a literature review type, with some informal interviews conducted for confir...

  16. Mutations in the Arabidopsis Lst8 and Raptor genes encoding partners of the TOR complex, or inhibition of TOR activity decrease abscisic acid (ABA) synthesis.

    Kravchenko, Alena; Citerne, Sylvie; Jéhanno, Isabelle; Bersimbaev, Rakhmetkazhi I; Veit, Bruce; Meyer, Christian; Leprince, Anne-Sophie

    2015-11-27

    The Target of Rapamycin (TOR) kinase regulates essential processes in plant growth and development by modulation of metabolism and translation in response to environmental signals. In this study, we show that abscisic acid (ABA) metabolism is also regulated by the TOR kinase. Indeed ABA hormone level strongly decreases in Lst8-1 and Raptor3g mutant lines as well as in wild-type (WT) Arabidopsis plants treated with AZD-8055, a TOR inhibitor. However the growth and germination of these lines are more sensitive to exogenous ABA. The diminished ABA hormone accumulation is correlated with lower transcript levels of ZEP, NCED3 and AAO3 biosynthetic enzymes, and higher transcript amount of the CYP707A2 gene encoding a key-enzyme in abscisic acid catabolism. These results suggest that the TOR signaling pathway is implicated in the regulation of ABA accumulation in Arabidopsis. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

    Nho, Richard

    2018-01-01

    The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell metabolism, proliferation, differentiation, and survival. This pathway is dysregulated in a variety of diseases, including neoplasia, immune-mediated diseases, and fibroproliferative diseases such as pulmonary fibrosis. The mTOR kinase is frequently referred to as the master regulator of this pathway. Alterations in mTOR signaling are closely associated with dysregulation of autophagy, inflammation, and cell growth and survival, leading to the development of lung fibrosis. Inhibitors of mTOR have been widely studied in cancer therapy, as they may sensitize cancer cells to radiation therapy. Studies also suggest that mTOR inhibitors are promising modulators of fibroproliferative diseases such as idiopathic pulmonary fibrosis (IPF) and radiation-induced pulmonary fibrosis (RIPF). Therefore, mTOR represents an attractive and unique therapeutic target in pulmonary fibrosis. In this review, we discuss the pathological role of mTOR kinase in pulmonary fibrosis and examine how mTOR inhibitors may mitigate fibrotic progression. PMID:29518028

  18. The AKT-mTOR signalling pathway in kidney cancer tissues

    Spirina, L. V.; Usynin, Y. A.; Kondakova, I. V.; Yurmazov, Z. A.; Slonimskaya, E. M.; Kolegova, E. S.

    2015-11-01

    An increased expression of phospho-AKT, m-TOR, glycogen regulator GSK-3-beta and transcription inhibitor 4E-BP1 was observed in kidney cancer tissues. Tumor size growth was associated with a high level of c-Raf and low content of phospho-m-TOR. Cancer metastasis development led to a decreased PTEN and phospho-AKT expression.

  19. Targeting mTOR in HIV-Negative Classic Kaposi's Sarcoma

    Ofer Merimsky

    2008-01-01

    Full Text Available A 66-year old female with HIV-negative classic Kaposi's sarcoma responded to mTOR targeting by rapamycin. The response was well documented by PET-CT. This case provides supporting evidence that the mTOR pathway may be important in the tumorigenesis of KS and that rapamycin may have activity in this disease.

  20. mTOR in squamous cell carcinoma of the oesophagus: a potential target for molecular therapy?

    Boone, J.; ten Kate, F. J. W.; Offerhaus, G. J. A.; van Diest, P. J.; Borel Rinkes, I. H. M.; van Hillegersberg, R.

    2008-01-01

    AIMS: The mammalian target of rapamycin (mTOR), an important regulator of protein translation and cell proliferation, is activated in various malignancies. In a randomised controlled trial of advanced renal cell carcinoma patients, targeted therapy to mTOR by means of rapamycin analogues has been

  1. Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.

    Galanopoulou, A.S.; Gorter, J.A.; Cepeda, C.

    2012-01-01

    The mammalian target of rapamycin (mTOR) signaling pathway regulates cell growth, differentiation, proliferation, and metabolism. Loss-of-function mutations in upstream regulators of mTOR have been highly associated with dysplasias, epilepsy, and neurodevelopmental disorders. These include tuberous

  2. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

    Sinclair, Linda V.; Finlay, David; Feijoo, Carmen; Cornish, Georgina H.; Gray, Alex; Ager, Ann; Okkenhaug, Klaus; Hagenbeek, Thijs J.; Spits, Hergen; Cantrell, Doreen A.

    2008-01-01

    Phosphatidylinositol-3-OH kinase (PI(3)K) and the nutrient sensor mTOR are evolutionarily conserved regulators of cell metabolism. Here we show that PI(3)K and mTOR determined the repertoire of adhesion and chemokine receptors expressed by T lymphocytes. The key lymph node-homing receptors CD62L

  3. mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

    Mee-Sup Yoon

    2017-10-01

    Full Text Available Maintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR is an evolutionarily conserved serine/threonine kinase, and is known to play vital roles in protein synthesis. Recent findings have continued to refine our understanding of the function of mTOR in maintaining skeletal muscle mass. mTOR controls the anabolic and catabolic signaling of skeletal muscle mass, resulting in the modulation of muscle hypertrophy and muscle wastage. This review will highlight the fundamental role of mTOR in skeletal muscle growth by summarizing the phenotype of skeletal-specific mTOR deficiency. In addition, the evidence that mTOR is a dual regulator of anabolism and catabolism in skeletal muscle mass will be discussed. A full understanding of mTOR signaling in the maintenance of skeletal muscle mass could help to develop mTOR-targeted therapeutics to prevent muscle wasting.

  4. [Phenotypic diversity of toxigenic Vibrio cholerae O1 El Tor strains identified in China].

    Zhao, Xuan; Zhang, Li; Li, Jie; Kan, Biao; Liang, Weili

    2014-05-01

    To understand the phenotypic diversity of toxigenic Vibrio cholerae O1 El Tor strains isolated from different provinces in China during the last 50 years. Traditional biotyping testings including susceptibility to polymyxin B, sensitivity to group IV phage, Voges-Proskauer test and haemolysis of sheep erythrocytes were conducted. Data from Biotype-specific phenotype analysis revealed that only 133 isolates carried the typical El Tor phenotypes while the other 251 isolates displayed atypical El Tor phenotypes. Combined with ctxB, rstR genotypes and phenotypic characteristics, 64 isolates were identified as typical El Tor biotype, 21 were El Tor variants that showing the typical El Tor biotype-specific phenotype but with ctxB(class). 280 isolates were defined as the hybrid groups with traits of both classical and El Tor biotypes that could be further classified into 45 groups, based on the combination of genotypes of ctxB, rstR and phenotypic characteristics. Toxigenic Vibrio cholerae O1 El Tor strains that isolated from different provinces in China displayed high phenotypic diversity. The traditional biotype traits could not be used to correctly distinguish the two different biotypes.

  5. Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators.

    Yuan Cheng

    Full Text Available Mammalian target of rapamycin (mTOR is a serine/threonine kinase and mTOR signaling is important in regulating cell growth and proliferation. Recent studies using oocyte- and granulosa cell-specific deletion of mTOR inhibitor genes TSC1 or TSC2 demonstrated the important role of mTOR signaling in the promotion of ovarian follicle development. We now report that treatment of ovaries from juvenile mice with an mTOR activator MHY1485 stimulated mTOR, S6K1 and rpS6 phosphorylation. Culturing ovaries for 4 days with MHY1485 increased ovarian explant weights and follicle development. In vivo studies further demonstrated that pre-incubation of these ovaries with MHY1485 for 2 days, followed by allo-grafting into kidney capsules of adult ovariectomized hosts for 5 days, led to marked increases in graft weights and promotion of follicle development. Mature oocytes derived from MHY1485-activated ovarian grafts could be successfully fertilized, leading the delivery of healthy pups. We further treated ovaries with the mTOR activator together with AKT activators (PTEN inhibitor and phosphoinositol-3-kinase stimulator before grafting and found additive enhancement of follicle growth. Our studies demonstrate the ability of an mTOR activator in promoting follicle growth, leading to a potential strategy to stimulate preantral follicle growth in infertile patients.

  6. Individualism-Collectivism And Organisational Value Types: A Case Of Malaysian Managers

    Fauziah Noordin; Jamil Hamali

    2011-01-01

    The results showed that Malaysian managers have significantly high levels of horizontal and vertical collectivism. Vertical collectivism has significant positive relationships with collegial, meritocratic, and leadership organisational values.

  7. The role of the TOR pathway in mediating the link between nutrition and longevity.

    Lushchak, Oleh; Strilbytska, Olha; Piskovatska, Veronika; Storey, Kenneth B; Koliada, Alexander; Vaiserman, Alexander

    2017-06-01

    The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability and other environmental cues. It allows the regulation of multiple cellular processes including protein and lipid synthesis, ribosome biogenesis, autophagy and metabolic processes. Being conserved across different phyla, TOR regulates longevity of various organisms in response to dietary conditions. In this review we described the main components of the TOR pathway and its upstream effectors and downstream processes in relation to aging. The potential contribution of the TOR pathway in lifespan-extending effects of varied dietary interventions, and the anti-aging drugs rapamycin and metformin direct or indirect regulation of TOR activity in yeasts, worms, flies and mammals are also discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. TOR (target of rapamycin) is a key regulator of triacylglycerol accumulation in microalgae.

    Imamura, Sousuke; Kawase, Yasuko; Kobayashi, Ikki; Shimojima, Mie; Ohta, Hiroyuki; Tanaka, Kan

    2016-01-01

    Most microalgae abundantly accumulate lipid droplets (LDs) containing triacylglycerols (TAGs) under several stress conditions, but the underlying molecular mechanism of this accumulation remains unclear. In a recent study, we found that inhibition of TOR (target of rapamycin), a highly conserved protein kinase of eukaryotes, by rapamycin resulted in TAG accumulation in microalgae, indicating that TOR negatively regulates TAG accumulation. Here, we show that formation of intracellular LDs and TAG accumulation were also induced in the unicellular green alga Chlamydomonas reinhardtii after exposure to Torin1 or AZD8055, which are novel TOR inhibitors that inhibit TOR activity in a manner different from rapamycin. These results supported quite well our previous conclusion that TOR is a central regulator of TAG accumulation in microalgae.

  9. Simulátor 3D tiskárny

    Čillo, Vladimír

    2015-01-01

    Tato bakalářská práce se zabýva návrhem a implementací simulátoru 3D tiskárny v jazyce C++ s využitím knihovny Qt. Simulátor předpokládá tiskárnu založenou na nejrozšířenější metodě 3D tisku - Fused Deposition Modeling. Vstupem simulátoru je 3D model ve formátu STL. Pro daný 3D model simulátor poskytuje odhad celkové doby tisku. Součástí simulace je také vizualizace procesu 3D tisku. Výsledkem práce je přenositelný program testovaný pod operačními systémy Linux a Windows. Funkčnost simulátoru...

  10. Tomato FK506 Binding Protein 12KD (FKBP12 mediates the interaction between rapamycin and Target of Rapamycin (TOR

    Fangjie Xiong

    2016-11-01

    Full Text Available Target of Rapamycin (TOR signaling is an important regulator in multiple organisms including yeast, plants and animals. However, the TOR signaling in plants is much less understood as compared to that in yeast and animals. TOR kinase can be efficiently suppressed by rapamycin in the presence of functional FK506 Binding Protein 12KD (FKBP12 in yeast and animals. In most examined higher plants rapamycin fails to inhibit TOR kinase due to the non-functional FKBP12. Here we find that tomato plants showed obvious growth inhibition when treated with rapamycin and the inhibitory phenotype is similar to suppression of TOR causing by active-site TOR inhibitors (asTORis such as KU63794, AZD8055 and Torin1. The chemical genetic assays using TOR inhibitors and heterologous expressing SlFKBP12 in Arabidopsis indicated that the TOR signaling is functional in tomato. The protein gel shifting and TOR inhibitors combination assays showed that SlFKBP12 can mediate the interaction between rapamycin and TOR. Furthermore, comparative expression profiling analysis between treatments with rapamycin and KU63794 identified highly overlapped Differentially Expressed Genes (DEGs which are involved in many anabolic and catabolic processes, such as photosynthesis, cell wall restructuring, and senescence in tomato. These observations suggest that SlFFBP12 is functional in tomato. The results provided basic information of TOR signaling in tomato, and also some new insights into how TOR controls plant growth and development through reprogramming the transcription profiles

  11. A Legume TOR Protein Kinase Regulates Rhizobium Symbiosis and Is Essential for Infection and Nodule Development1[OPEN

    Blanco, Lourdes; Quinto, Carmen

    2016-01-01

    The target of rapamycin (TOR) protein kinase regulates metabolism, growth, and life span in yeast, animals, and plants in coordination with nutrient status and environmental conditions. The nutrient-dependent nature of TOR functionality makes this kinase a putative regulator of symbiotic associations involving nutrient acquisition. However, TOR’s role in these processes remains to be understood. Here, we uncovered the role of TOR during the bean (Phaseolus vulgaris)-Rhizobium tropici (Rhizobium) symbiotic interaction. TOR was expressed in all tested bean tissues, with higher transcript levels in the root meristems and senesced nodules. We showed TOR promoter expression along the progressing infection thread and in the infected cells of mature nodules. Posttranscriptional gene silencing of TOR using RNA interference (RNAi) showed that this gene is involved in lateral root elongation and root cell organization and also alters the density, size, and number of root hairs. The suppression of TOR transcripts also affected infection thread progression and associated cortical cell divisions, resulting in a drastic reduction of nodule numbers. TOR-RNAi resulted in reduced reactive oxygen species accumulation and altered CyclinD1 and CyclinD3 expression, which are crucial factors for infection thread progression and nodule organogenesis. Enhanced expression of TOR-regulated ATG genes in TOR-RNAi roots suggested that TOR plays a role in the recognition of Rhizobium as a symbiont. Together, these data suggest that TOR plays a vital role in the establishment of root nodule symbiosis in the common bean. PMID:27698253

  12. Tomato FK506 Binding Protein 12KD (FKBP12) Mediates the Interaction between Rapamycin and Target of Rapamycin (TOR).

    Xiong, Fangjie; Dong, Pan; Liu, Mei; Xie, Gengxin; Wang, Kai; Zhuo, Fengping; Feng, Li; Yang, Lu; Li, Zhengguo; Ren, Maozhi

    2016-01-01

    Target of Rapamycin (TOR) signaling is an important regulator in multiple organisms including yeast, plants, and animals. However, the TOR signaling in plants is much less understood as compared to that in yeast and animals. TOR kinase can be efficiently suppressed by rapamycin in the presence of functional FK506 Binding Protein 12 KD (FKBP12) in yeast and animals. In most examined higher plants rapamycin fails to inhibit TOR kinase due to the non-functional FKBP12. Here we find that tomato plants showed obvious growth inhibition when treated with rapamycin and the inhibitory phenotype is similar to suppression of TOR causing by active-site TOR inhibitors (asTORis) such as KU63794, AZD8055, and Torin1. The chemical genetic assays using TOR inhibitors and heterologous expressing SlFKBP12 in Arabidopsis indicated that the TOR signaling is functional in tomato. The protein gel shifting and TOR inhibitors combination assays showed that SlFKBP12 can mediate the interaction between rapamycin and TOR. Furthermore, comparative expression profile analysis between treatments with rapamycin and KU63794 identified highly overlapped Differentially Expressed Genes (DEGs) which are involved in many anabolic and catabolic processes, such as photosynthesis, cell wall restructuring, and senescence in tomato. These observations suggest that SlFFBP12 is functional in tomato. The results provided basic information of TOR signaling in tomato, and also some new insights into how TOR controls plant growth and development through reprogramming the transcription profiles.

  13. The emerging role of m-TOR up-regulation in brain Astrocytoma.

    Ryskalin, Larisa; Limanaqi, Fiona; Biagioni, Francesca; Frati, Alessandro; Esposito, Vincenzo; Calierno, Maria Teresa; Lenzi, Paola; Fornai, Francesco

    2017-05-01

    The present manuscript is an overview of various effects of mTOR up-regulation in astrocytoma with an emphasis on its deleterious effects on the proliferation of Glioblastoma Multiforme. The manuscript reports consistent evidence indicating the occurrence of mTOR up-regulation both in experimental and human astrocytoma. The grading of human astrocytoma is discussed in relationship with mTOR up-regulation. In the second part of the manuscript, the biochemical pathways under the influence of mTOR are translated to cell phenotypes which are generated by mTOR up-regulation and reverted by its inhibition. A special section is dedicated to the prominent role of autophagy in mediating the effects of mTOR in glioblastoma. In detail, autophagy inhibition produced by mTOR up-regulation determines the fate of cancer stem cells. On the other hand, biochemical findings disclose the remarkable effects of autophagy activators as powerful inducers of cell differentiation with a strong prevalence towards neuronal phenotypes. Thus, mTOR modulation acts on the neurobiology of glioblastoma just like it operates in vivo at the level of brain stem cell niches by altering autophagy-dependent cell differentiation. In the light of such a critical role of autophagy we analyzed the ubiquitin proteasome system. The merging between autophagy and proteasome generates a novel organelle, named autophagoproteasome which is strongly induced by mTOR inhibitors in glioblastoma cells. Remarkably, when mTOR is maximally inhibited the proteasome component selectively moves within autophagy vacuoles, thus making the proteasome activity dependent on the entry within autophagy compartment.

  14. Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling.

    Nelson, Nicholas; Clark, Geoffrey J

    2016-06-07

    The TOR pathway is a vital component of cellular homeostasis that controls the synthesis of proteins, nucleic acids and lipids. Its core is the TOR kinase. Activation of the TOR pathway suppresses autophagy, which plays a vital but complex role in tumorigenesis. The TOR pathway is regulated by activation of the Ras-related protein Rheb, which can bind mTOR. The Hippo pathway is a major growth control module that regulates cell growth, differentiation and apoptosis. Its core consists of an MST/LATS kinase cascade that can be activated by the RASSF1A tumor suppressor. The TOR and Hippo pathways may be coordinately regulated to promote cellular homeostasis. However, the links between the pathways remain only partially understood. We now demonstrate that in addition to mTOR regulation, Rheb also impacts the Hippo pathway by forming a complex with RASSF1A. Using stable clones of two human lung tumor cell lines (NCI-H1792 and NCI-H1299) with shRNA-mediated silencing or ectopic overexpression of RASSF1A, we show that activated Rheb stimulates the Hippo pathway, but is suppressed in its ability to stimulate the TOR pathway. Moreover, by selectively labeling autophagic vacuoles we show that RASSF1A inhibits the ability of Rheb to suppress autophagy and enhance cell growth. Thus, we identify a new connection that impacts coordination of Hippo and TOR signaling. As RASSF1A expression is frequently lost in human tumors, the RASSF1A status of a tumor may impact not just its Hippo pathway status, but also its TOR pathway status.

  15. Level of understanding of innovation among the Malaysian executives

    Abidin, Norkisme Zainal; Suradi, Nur Riza Mohd; Shahabuddin, Faridatulazna; Mustafa, Zainol; Ismail, Wan Rosmanira

    2014-06-01

    Innovation is among the most frequently used word in the business world today. While many businessman and executives agree that innovation is needed to sustain their long term business success, many struggle to understand the concept of innovation. This study aims to measure the understanding level of innovation among the Malaysian executives using a survey questionnaire. Questions regarding innovation were posted to the respondents and they were requested to answer either it was True or False. Each respondent was given scores for their correct answers. The score of the right answers were then categorized into low, moderate and high understanding level. Results of the survey revealed that the understanding level of innovation among the Malaysian Executives is still at moderate level thus leading to the failure of many initiatives introduced by the organization or the government.

  16. Tracking of Radioactive Sources in Malaysian Nuclear Agency

    Mohd Fazlie Abdul Rashid; Noor Fadilla Ismail; Khairuddin Mohamad Kontol; Hairul Nizam Idris; Azimawati Ahmad; Suzilawati Muhd Sarowi; Raymond, Y.T.L.

    2014-01-01

    Radioactive materials are used in Malaysian Nuclear Agency for various purposes such as research and development, calibration, tracer and irradiation. Inventory of radioactive materials is crucial for ensuring the security and control of all radioactive materials owned and used so as not to be lost or fall into the hands of people who do not have permission to possess or use it. Experience in many countries around the world proves that the improper inventory of radioactive material would lead to loss of control of radioactive materials and will eventually cause an accident of radiation exposure. Radioactive material database has been developed for the need to ensure traceability of radioactive materials in Malaysian Nuclear Agency. Records of radioactive materials are regularly updated based on the classification of the type of radionuclide, the total distribution in each building and the initial activity of radioactive sources. (author)

  17. Spirituality Moderates Hopelessness, Depression, and Suicidal Behavior among Malaysian Adolescents.

    Talib, Mansor Abu; Abdollahi, Abbas

    2017-06-01

    Suicide is an important public health problem for adolescents, and it is essential to increase our knowledge concerning the etiology of suicide among adolescent students. Therefore, this study was designed to examine the associations between hopelessness, depression, spirituality, and suicidal behavior, and to examine spirituality as a moderator between hopelessness, depression, and suicidal behavior among 1376 Malaysian adolescent students. The participants completed measures of depression, hopelessness, daily spiritual experience, and suicidal behavior. Structural equation modeling indicated that adolescent students high in hopelessness and depression, but also high in spirituality, had less suicidal behavior than others. These findings reinforce the importance of spirituality as a protective factor against hopelessness, depression, and suicidal behavior among Malaysian adolescent students.

  18. Modeling a National Collaborative Digital Library for Malaysian Secondary Schools

    N.N. Edzan

    2004-09-01

    Full Text Available This paper describes the conceptualisation of a model for a collaborative digital library specially tailored for Malaysian secondary schools, which will support classroom teaching and learning. The move towards collaboratively building the contents of a digital library is a fairly recent trend and it simulates an environment where partners are empowered to participate in building and up keeping the knowledge contents of the system. The conceptualisation of a Malaysian digital library is in line with the governments efforts in establishing SMART schools. However, various issues such as identifying local resources, ascertaining the needs of it users, and establishing a framework to meet these needs, must be addressed before the digital library can be fully implemented. It may be approached through the establishment of test beds in a particular learning institution, before nationwide implementation.

  19. Malaysian Container Seaport-Hinterland Connectivity: Status, Challenges and Strategies

    Shu-Ling Chen

    2016-09-01

    Full Text Available This paper adopts a qualitative methodology to assess the Malaysian container seaport-hinterland connectivity from the perspective of its physical properties. The findings reveal that although Malaysia's major container seaports are connected to the hinterlands through road and rail transport, they are highly dependent on road. These seaports are also connected to inland freight facilities such as dry ports and ICDs, which are positioned as transit points to help connect exporters and importers in the hinterlands to seaports as well as facilitating regional and cross-border trades. This paper suggests that the quality of hinterland connectivity of Malaysian container seaports could be improved by implementing strategies which tackle the existing challenges including overcoming an extremely imbalanced modal split, insufficient rail capacity and limited train services, increasing road congestion and the limitations of space restriction in some inland facilities.

  20. The impact of derivatives on Malaysian stock market

    Malim, M. R.; Halim, F. A.; Murad, A.; Maad, H. A.; Annuar, N. F. M.

    2017-09-01

    The essential of derivatives has been discovered by researchers over recent decade. However, the conclusions made regarding the impact of derivatives on stock market volatility remains debatable. The main objective of this study is to examine the impact of derivatives on Malaysian stock market volatility by exploring FTSE Bursa Malaysia Kuala Lumpur Composite Index Futures (BMD FKLI) using FBM KLCI as the underlying asset. Generalized Autoregressive Conditional Heteroskedasticity (GARCH) (1, 1) model was employed to realize the objective. The results have shown that the introduction of futures trading has decreased the volatility of Malaysian stock market. The volatility increased vigorously during the Asian financial crisis compared to the Global financial crisis. However, the role of futures as a risk transfer is agreed as it could improve the market by decreasing the volatility in the spot market.

  1. FACTORS INFLUENCING SEXUAL HARASSMENT IN THE MALAYSIAN WORKPLACE

    Lee Kum Chee

    2007-01-01

    Full Text Available This study examined the potential risks factors associated with sexually harassing behaviors within the framework of the four-factor model of sexual harassment. The factors examined are unprofessional work environment, skewed gender ratio in the workplace, knowledge of grievance procedure for sexual harassment, sexist attitudes among co-workers, privacy of workspace, physical attractiveness, dress manner of victims, job status, and sex roles. The dependent variable is incidence of sexual harassment which was evaluated using the Sexual Experience Questionnaire developed by Fitzgerald, Shullman, Bailey, Richards, Swecker, Gold, Ormerod, and Weitzman (1988. Data were collected from 657 women employees working in Malaysian organizations. The findings showed that the predictions of the four-factor model are also largely true in the case of the Malaysian workplace. The study also found that sexual harassment behaviors are fairly widespread in Malaysia.

  2. Women in the Malaysian parliament: Do they matter?

    Ummu Atiyah Ahmad Zakuan

    2010-12-01

    Full Text Available This paper explores the impact of women’s representation in the lower house (Dewan Rakyat of the Malaysian Parliament. It is an attempt to see whether women representatives in the Dewan Rakyat are able to make any impact or difference in parliament, in the context of making policy output more women-friendly. Available studies conducted mainly in the West have shown that women legislators are more responsive to women’s interest than their male counterparts, developing distinctive sets of concerns and priorities and taking leading parts in formulating policies that favour women. Through textual analysis of nine years of the Malaysian Parliament (1999-2007, this paper examines the issues that have been introduced and discussed by the women and the impact they made in parliament. It also reveals the critical actors initiating or introducing women-related issues.

  3. Malaysian Journal of Medical Sciences’ Publishing Report (2014–2015)

    Zulkapli, Nour Azimah; Sobi, Suhana; Mohd Zubaidi, Nor Azlina; Abdullah, Jafri Malin

    2016-01-01

    The Malaysian Journal of Medical Sciences (MJMS) has conducted a simple analysis of its scholarly publication, based on the auto-generated data compiled from ScholarOne Manuscripts™, an innovative, web-based, submission and peer-review workflow solution for scholarly publishers. The performance of the MJMS from 2014–2015 is reported on in this editorial, with a focus on the pattern of manuscript submission, geographical contributors and the acceptance-rejection rate. The total number of manuscript submissions has increased from 264 in 2014, to 272 in 2015. Malaysians are the main contributors to the MJMS. The total number of manuscript rejections following the review process was 79 (29.9%) in 2014, increasing to 92 (33.8%) the following year, in accordance with the exacting quality control criteria applied by the journal’s editor to the submitted manuscripts. PMID:27660539

  4. Conjunctions in Malaysian Secondary School English Language Textbooks

    Alicia Philip

    2012-05-01

    Full Text Available The present research aims to investigate the distribution pattern of conjunctions and their ranking in two different corpora, namely the Malaysian school English language Textbook Corpus (Textbook Corpus and the British National Corpus (BNC. An additional objective of the study was to find out how conjunctions had been presented in the Malaysian school English language textbooks (Forms 1-5. The method applied was qualitative content analysis. The findings indicated that coordinating conjunctions were the most frequent conjunctions that occurred in the five textbooks followed by subordinating and correlative conjunctions. The ranking of the different types of conjunctions in the Textbook Corpus was similar to that of the reference corpus, BNC. The results also indicated that the textbooks failed to present conjunctions effectively. The findings are expected to help textbook developers or language teachers in developing or adapting learning materials. Keywords: Conjunctions, Textbook evaluation, Distribution patterns

  5. Foreign Nationals as Offenders and Victims in Malaysian Crime News

    Misman Norealyna

    2017-01-01

    Full Text Available Foreign nationals in Malaysia come from all corners of the world. They are here as migrant labour, highly skilled and professional migrants (expatriates, illegal migrants, refugees, asylum-seekers (Burmese asylum seekers with UNHCR card, forced migrants (human trafficking victims, students, and tourists. The influx of foreign nationals residing in Malaysia coincides with greater number of crime news featuring foreign nationals. This study explores the social construction of foreign nationals as the ‘other’ in the local crime news published by Malaysian newspapers. 94 news headlines and lead sentences of local crime news involving foreign nationals were identified and analysed for this study. Findings suggest that Malaysian newspapers magnify foreign nationals’ migration status in each crime news.

  6. Motivating talents in Thai and Malaysian service firms

    Lehmann, Sanne

    2009-01-01

    Talent development in Thailand and Malaysian service firms has become a prioritized human resource management practice as these societies move toward knowledge-based economies. This paper discusses talent management in the social, organizational and managerial context of firms in Thailand...... and Malaysia, and argues that such structures often counterbalance investments made in talent development. The paper concludes that new human resource management practices do not produce a difference per se. It is the mindset and attitude of various managers that makes the difference. The learning...... for practitioners is that they need to adapt existing social and organizational structures to their new human resource management practices. The paper is based mainly on qualitative interviews with human resource managers from Thai and Malaysian service firms....

  7. The Malaysian Fifth Fuel Policy: Re-strategising the Malaysian Renewable Energy Initiatives

    Maulud, A.L.; Saidi, H.

    2012-01-01

    The power industry is the most crucial and strategic sector for any country to achieve its vision. Due to the fast depletion and high cost of fossil fuel, this is now a threat to sustainable growth. Attention is now focused on renewable energies as an alternative. In Malaysia, renewable energy was included in the 8th Malaysia Plan (2000–2005) with a target of 500 MW out of the 20,000 MW total generation capacity. However, for the first 10 years (2000–2010) only 41.5 MW planting up has been achieved. This paper recommends strategies, implementation mechanism, and financial framework to ensure success of the initiatives. Some of the recommendations were currently being implemented such as the Green Technology Fund and the Fit-In-Tariff. In addition, this paper proposes the incorporation of a Malaysian Renewable Energy Development Board with wide legislative and executive powers, that would be a strong champion of the RE initiatives. Its primary function would be, inter alia, cross-ministry coordination, tariff fixation, regulating utilization of renewable biomass waste, institute fiscal incentives such as investment incentives, tax holidays, removal of barriers, and initiate government funded Research, Development and Demonstration (RD and D) initiatives.

  8. Determinants of Fresh Fish Purchasing Behavior Among Malaysian Consumers

    Abdullahi Farah Ahmed; Zainalabidin Mohamed and Mohd Mansor Ismail

    2011-01-01

    The study investigates demographic and attitudinal characteristics that can affect the purchase decisions of marine fish among Malaysian consumers. A survey was conducted on Kuala Lumpur households using structured questionnaires. Seven hundred respondents were randomly interviewed with regard to their buying behaviour pattern, attitude and perception on fresh marine fish consumption. The data were analyzed using a logit binary model. It was found that the size and income of the households, g...

  9. Employability Skill Acquisition among Malaysian Community College Students

    M. K. Omar; A. R. Bakar; A. Mat Rashid

    2012-01-01

    The objective of this study was to assess the acquisition of employability skills among Malaysian community college students. The sample size of the present study 325 students selected randomly. Employability skills were measured using an instrument developed by the Secretaryâs Commission on Achieving Necessary Skills (SCANS). The overall mean of employability skills among community college students was 3.63 (S.D. = 0.47). Thus, we consider the employability skills of community college studen...

  10. The Antecedents of Automobile Brand Loyalty: Evidence from Malaysian

    Mabkhot, Hashed Ahmed; Salleh, Salniza MD; Shaari, Hasnizam

    2016-01-01

    This study empirically examined the mediating effect of brand satisfaction on the relationship between brand image and brand loyalty among Malaysian customer toward local automobile brands. Four hypotheses were developed to test hypothesizing relationships among brand image, brand satisfaction on brand loyalty. Data collected from customers of automobile brands in north Malaysia peninsula from three states which were Kedah, Penang, and Perlis. This study applies partial least squares to a sam...

  11. The Role of Macroeconomic Fundamentals in Malaysian Post Recession Growth

    Lee, Chin

    2013-01-01

    This study aims to find out the role of macroeconomic fundamentals in Malaysian post recession growth. The selected macroeconomic variables are exports, imports, price level, money supply, interest rate, exchange rate and government expenditure. The technique of cointegration was employed to assess the long run equilibrium relationships among the variables. Then, this study performs the Granger causality tests based on VECM to establish the short run causality among the variables. The long-ru...

  12. Innovation and technical efficiency in Malaysian family manufacturing industries

    Susila Munisamy; Edward Wong Sek Khin; Chia Zi Fon

    2015-01-01

    This study investigates the technical efficiency for each industry in the Malaysian manufacturing sector is estimated by using Data Envelopment Analysis (DEA). In order to pursue a balance of innovation between long-term and short-term performance strategy, we integrate the Balance Scorecard (BSC) approach with DEA. Furthermore, this paper looks at the determinants of efficiency using the Tobit regression model. In measuring the level of firms’ efficiency and innovation, the wood and wood b...

  13. Mobile learning in Malaysian schools: opportunities and challenges

    Mohamad, Mariam; Woollard, John

    2011-01-01

    This study established the emerging themes in implementing mobile learning via mobile phones to support English Language learning in Malaysian schools. The findings were gathered from English subject leaders, ICT subject leaders, head teachers and deputy head teachers from 4 schools in the United Kingdom. In addition, the study also gathered the perspectives from English subject leaders, ICT subject leaders, head teachers, deputy head teachers from 9 schools and the officers in the Ministry o...

  14. Issues and challenges in implementing mobile learning in malaysian schools

    Mohamad, Mariam; Woollard, John

    2012-01-01

    This study describes the issues and challenges in implementing mobile learning via mobile phones to support English Language learning in Malaysian schools. The findings are drawn from interviews of English subject leaders, ICT subject leaders, head teachers and deputy head teachers from 4 schools in the United Kingdom. In addition, the study also describes the perspectives from the experts in education in Malaysia. They are English subject leaders, ICT subject leaders, head teachers, deputy h...

  15. Religiosity and Volunteering Intention Among Undergraduate Malaysian Muslim Students

    Sallam A.A.A.; Abdullah S.; Ramli A.J .; Hussin N.S.; Ahmad Z.; Bahari A.

    2018-01-01

    This paper deals with the question: To what extent do religiosity characteristics, contribute to the influence of volunteering intention among Malaysian Muslim students during disasters? To answer this research question, we focused the students in public universities. The finding concerns found that religiosity increases the likelihood of volunteering intention, implying that religious affiliation of youth increases the likelihood of volunteering. This is in line with previous research, that ...

  16. A supplier selection strategy within the Malaysian telecommunications industry

    Sharif, A M; Abdul-Rahim, S; Gallear, D; Irani, Z

    2009-01-01

    The telecommunication industry in Malaysia has grown rapidly over the last 15 years, with effective supply chain management becoming increasing important within the sector. A multitude of providers and part owned Malaysian government companies, vendors and suppliers are involved in generating and creating value-adding products and services within this sector (across wireless, wireline, broadband business and consumer lines of business). This paper describes key challenges facing a major telec...

  17. An Energy Consumption Study for a Malaysian University

    Fu E. Tang

    2012-01-01

    The increase in energy demand has raised concerns over adverse impacts on the environment from energy generation. It is important to understand the status of energy consumption for institutions such as Curtin Sarawak to ensure the sustainability of energy usage, and also to reduce its costs. In this study, a preliminary audit framework was developed and was conducted around the Malaysian campus to obtain information such as the number and specifications of electrical appl...

  18. Regionalization Impact on Performance Management for Malaysian Multinational Companies

    Tan, We Chang

    2015-01-01

    Operation offshore or regionalization is one of the key strategies by many Malaysian MNCs nowadays. The purpose is to expand their business and also establish a sustainable business model. This change in business direction introduces impacts to performance management framework. If these impacts are not properly handled, it may leads to business expansion failure. The current performance management framework will have to be enhanced such that the regional needs in the performance management ar...

  19. Women in the Malaysian parliament: Do they matter?

    Ummu Atiyah Ahmad Zakuan

    2010-01-01

    This paper explores the impact of women’s representation in the lower house (Dewan Rakyat) of the Malaysian Parliament. It is an attempt to see whether women representatives in the Dewan Rakyat are able to make any impact or difference in parliament, in the context of making policy output more women-friendly. Available studies conducted mainly in the West have shown that women legislators are more responsive to women’s interest than their male counterparts, developing distinctive sets of conc...

  20. Supply and Demand Model for the Malaysian Cocoa Market

    Abdel Hameed, Amna Awad; Hasanov, Akram; Idris, Nurjihan; Abdullah, Amin Mahir; Mohamed Arshad, Fatimah; Shamsudin, Mad Nasir

    2009-01-01

    This paper investigates a system of supply, demand, and price equations for Malaysian cocoa using annual data over the period 1975-2008. Theoretically, in supply and demand models, the price variable is treated as endogenous. However, Hausman specification test result indicates that there is no simultaneity problem in the model. Thus, we estimate the system of equations utilizing the Seemingly Unrelated Regression (SUR) estimation technique which might be considered a more effi...

  1. E-democracy and public administrators: the Malaysian case

    Abu Bakar, Abdul Gapar

    2017-01-01

    The thesis investigates public administrators’ use of interactive Information and Communications Technologies (ICTs) in the Malaysian Federal Public Service (MFPS). It describes qualitative research which identifies the nature of e-democracy practices in policy development in the MFPS. In-depth interviews and scholarly as well as government documents provide empirical evidence. Through a survey of literature, contextual features such as absence of policy in the MFPS for e-democracy, constitut...

  2. Exploring Familial Themes in Malaysian Students’ Eating Behaviors

    Car Mun Kok

    2013-01-01

    Food-related attitudes and habits are integral to overall well-being, especially among international college students who often practice poor eating habits and experience high levels of stress from factors like school and sociocultural adjustment. Utilizing in-depth interviews, this study explored how family experiences impact food-related habits, attitudes, and beliefs of Malaysian college students in the U.S. Findings indicate that early experiences with family substantially impact current ...

  3. Perceived sources of stress among Malaysian dental students

    Babar, Muneer G.; Hasan, Syed S.; Ooi, Yong J.; Ahmed, Syed I.; Wong, Pei S.; Ahmad, Siti F.; MNM-Rosdy, Nik M.; Malik, Normaliza A.

    2015-01-01

    Objectives The study objectives were to identify the stress levels and to explore the impact of students' year of study and gender on the perceived sources of stress among Malaysian dental students. Methods This was a cross-sectional study involving dental students from year one to year five from private and public universities in Malaysia. The study was formally approved by the Research and Ethics Committee, International Medical University Malaysia. Dental Environment Stress (DES) questionn...

  4. Representation of Business Culture in Selected Malaysian Short Stories

    Zanirah Wahab; Radzuwan Ab Rashid

    2016-01-01

    Globalisation has brought numerous changes in all aspects of life especially in the economic sector. For the past few decades, the importance of economic growth and achievement has become the “obsession” of people around the world. Malaysia is no exception to this economic globalisation whirlwind. As well-known business hub with cutting edge technologies and blooming business enterprises, economic globalisation has shifted the way Malaysian society view things or connect with one another. Thi...

  5. An empirical study of Malaysian firms' capital structure

    Zain, Sharifah Raihan Syed Mohd

    2003-01-01

    Merged with duplicate record 10026.1/821 on 27.03.2017 by CS (TIS) It is sometimes purported that one of the factors affecting a firm's value is its capital structure. The event of the 1997 Asian financial crisis was expected to affect the firms' gearing level as the firms' earnings deteriorated and the capital market collapsed. The main objective of this research is to examine empirically the determinants of the capital structure of Malaysian firms. The main additional aim is ...

  6. Safety Culture and Issue in the Malaysian Manufacturing Sector

    Ali Danish; Yusof Yusri; Adam Anbia

    2017-01-01

    . This paper highlights the Safety culture and issue in the Malaysian Manufacturing Sector and emphasis the high occupational accidents due to lack of safety culture and non-compliance of the requirements of Occupational Safety and Health Act 1994. The aim of this study is to review the occupational accidents occurrence in the Malaysia workplace since 2012-2016. Malaysia aimed to reduce the occupational accidents, the results show by DOSH increase that Occupational Noise Induced Hearing Loss ...

  7. Factors Influencing Students' Self-Concept among Malaysian Students

    Z. Ishak; S. Jamaluddin; F.P Chew

    2010-01-01

    This paper examines the students’ self-concept among 16- and 17- year- old adolescents in Malaysian secondary schools. Previous studies have shown that positive self-concept played an important role in student adjustment and academic performance during schooling. This study attempts to investigate the factors influencing students’ perceptions toward their own self-concept. A total of 1168 students participated in the survey. This study utilized the CoPs (UM) instrument to measure self-concept...

  8. Belongingness: Malaysian nurses’ experiences in the clinical workplace

    Mohamed, Zainah

    2017-01-01

    The need to belong has been proposed to be the most basic need for human psychological wellbeing. Lack of belongingness has been associated with stress, anxiety, and lack of esteem. Understanding the nature of nurses’ interconnection with others and their perceptions of belongingness has been linked to social and psychological functioning in the workplace. The purpose of this mixed-methods study was to explore factors contributing to Malaysian nurses’ sense of belonging in the workplace. Reg...

  9. Essential Oil Compositions of Malaysian Lauraceae: A Mini Review

    Wan Mohd Nuzul Hakimi Salleh, Farediah Ahmad * , Khong Heng Yen, Razauden Mohamed Zulkifli

    2016-03-01

    Full Text Available Essential oils have been largely employed for human need due to their antibacterial, antifungal and insecticidal activities. At present, approximately 3000 essential oils are known, 300 of which are commercially important. Essential oils or some of their components are used in perfumes and make-up products, sanitary products, dentistry, agriculture, as food preservers and additives, and as natural remedies. The essential oil compositions of Malaysian Lauraceae family have been investigated for many years. In the recent years, studies on the essential oils of the species have been progressing and many of them have reported interesting pharmacological activities. In this article, we summarized and updated the chemical compositions and biological activities of Malaysian Lauraceae. Throughout our literature review, only four genera which are Lindera, Beilschmiedia, Litsea, and Cinnamomum have been studied for their essential oil compositions in Malaysia. They were found to contain mainly safrole, eugenol, linalool, camphor, benzyl benzoate or cinnamaldehyde as major components. There were significant priorities to find out the details of the chemical compositions of the essential oils from Malaysian Lauraceae. Therefore, more clinical studies on the toxicity of the essential oil of the species are also crucial to ensure their safety and to assess their eligibility to be used as the sources of modern medicines.

  10. Defining Malaysian Knowledge Society: Results from the Delphi Technique

    Hamid, Norsiah Abdul; Zaman, Halimah Badioze

    This paper outlines the findings of research where the central idea is to define the term Knowledge Society (KS) in Malaysian context. The research focuses on three important dimensions, namely knowledge, ICT and human capital. This study adopts a modified Delphi technique to seek the important dimensions that can contribute to the development of Malaysian's KS. The Delphi technique involved ten experts in a five-round iterative and controlled feedback procedure to obtain consensus on the important dimensions and to verify the proposed definition of KS. The finding shows that all three dimensions proposed initially scored high and moderate consensus. Round One (R1) proposed an initial definition of KS and required comments and inputs from the panel. These inputs were then used to develop items for a R2 questionnaire. In R2, 56 out of 73 items scored high consensus and in R3, 63 out of 90 items scored high. R4 was conducted to re-rate the new items, in which 8 out of 17 items scored high. Other items scored moderate consensus and no item scored low or no consensus in all rounds. The final round (R5) was employed to verify the final definition of KS. Findings and discovery of this study are significant to the definition of KS and the development of a framework in the Malaysian context.

  11. The Idea of a University: Rethinking the Malaysian Context

    Chang Da Wan

    2015-07-01

    Full Text Available This article explores the idea of a university with a specific focus in the Malaysian context. We begin the article guided by these questions—“What is a university?” and “What are universities for?”—in examining the historical and conceptual development of universities. This is followed by asking a more specific question—“What are Malaysian universities for?”—in which we discussed the overarching roles of public and private universities in this developing country. Having examined the roles of public and private universities, and taken into context the complexity and challenges surrounding these important societal institutions, we discuss two “experimental” initiatives in Malaysia: the APEX University (Accelerated Program for Excellence focusing on sustainability and the “humanversity”. On the one hand, these initiatives are intended to prepare and transform Malaysian universities to address not only the needs of society today, but critically, of tomorrow. On the other hand, they have implications and contributions to frame our thinking about the future ideas of a university not only in Malaysia, but regionally and globally.

  12. Representation of Business Culture in Selected Malaysian Short Stories

    Zanirah Wahab

    2016-11-01

    Full Text Available Globalisation has brought numerous changes in all aspects of life especially in the economic sector. For the past few decades, the importance of economic growth and achievement has become the “obsession” of people around the world. Malaysia is no exception to this economic globalisation whirlwind. As well-known business hub with cutting edge technologies and blooming business enterprises, economic globalisation has shifted the way Malaysian society view things or connect with one another. This paper explores how business culture is represented in Malaysian short stories as well as examines the stand of the writers regarding the impact of economic globalisation on their society. In doing so, this paper compares and critically analyses three - selected short stories in the light of globalisation theory. The five main characteristics of globalisation namely, internationalisation, liberalisation, universalisation, westernisation and deterritorialisation are taken into account while dissecting these literary works. From the analysis, each writer voices out similar concerns regarding the impact of economic globalisation on their society. Malaysian fictions are preoccupied with the erosion of good values and the nation’s physical changes due to economic globalisation. The parallel stand demonstrates that regardless of their ethnicity and gender, they react uniformly to the changes.

  13. Malaysian public perception towards nuclear power energy-related issues

    Misnon, Fauzan Amin; Hu, Yeoh Siong; Rahman, Irman Abd.; Yasir, Muhamad Samudi

    2017-01-01

    Malaysia had considered nuclear energy as an option for future electricity generation during the 9th Malaysia Development Plan. Since 2009, Malaysia had implemented a number of important preparatory steps towards this goal, including the establishment of Nuclear Power Corporation of Malaysia (MNPC) as first Nuclear Energy Programme Implementing Organization (NEPIO) in Malaysia. In light of the establishment of MNPC, the National Nuclear Policy was formulated in 2010 and a new comprehensive nuclear law to replace the existing Atomic Energy Licensing Act (Act 304) is currently in the pipeline. Internationally, public acceptance is generally used to gauge the acceptance of nuclear energy by the public whenever a government decides to engage in nuclear energy. A public survey was conducted in between 14 March 2016 to 10 May 2016 focusing on the Malaysian public acceptance and perception towards the implementation of nuclear energy in Malaysia. The methodology of this research was aim on finding an overview of the general knowledge, public-relation recommendation, perception and acceptance of Malaysian towards the nuclear power development program. The combination of information gathered from this study can be interpreted as an indication of the complexity surrounding the development of nuclear energy and its relationship with the unique background of Malaysian demography. This paper will focus mainly on energy-related section in the survey in comparison with nuclear energy.

  14. Phenolic acid composition and antioxidant properties of Malaysian honeys.

    Khalil, M I; Alam, N; Moniruzzaman, M; Sulaiman, S A; Gan, S H

    2011-08-01

    The phenolic acid and flavonoid contents of Malaysian Tualang, Gelam, and Borneo tropical honeys were compared to those of Manuka honey. Ferric reducing/antioxidant power assay (FRAP) and the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical-scavenging activities were also quantified. All honey extracts exhibited high phenolic contents (15.21 ± 0.51- 42.23 ± 0.64 mg/kg), flavonoid contents (11.52 ± 0.27- 25.31 ± 0.37 mg/kg), FRAP values (892.15 ± 4.97- 363.38 ± 10.57 μM Fe[II]/kg), and high IC₅₀ of DPPH radical-scavenging activities (5.24 ± 0.40- 17.51 ± 0.51 mg/mL). Total of 6 phenolic acids (gallic, syringic, benzoic, trans-cinnamic, p-coumaric, and caffeic acids) and 5 flavonoids (catechin, kaempferol, naringenin, luteolin, and apigenin) were identified. Among the Malaysian honey samples, Tualang honey had the highest contents of phenolics, and flavonoids, and DPPH radical-scavenging activities. We conclude that among Malaysian honey samples, Tualang honey is the richest in phenolic acids, and flavonoid compounds, which have strong free radical-scavenging activities. © 2011 Institute of Food Technologists®

  15. The Effect of E-commerce on Malaysian Tax System: an Empirical Evidence From Academicians and Malaysian Tax Practitioners

    Palil, Mohd Rizal

    2004-01-01

    The explosion of information technology (IT) nowadays has created new phenomena in shopping activities. Consumers can easily buy products via Internet. Within a minute, the products will be delivered instantly and accurately. This scenario is known as e-commerce. The emergence of e-commerce affects consumers' shopping behavior as well as taxation system. The objective of this research is to reveal the effects of e-commerce upon Malaysian taxation system by emphasizing in scope of charge 'deri...

  16. Mammalian target of rapamycin (mTOR): a central regulator of male fertility?

    Jesus, Tito T; Oliveira, Pedro F; Sousa, Mário; Cheng, C Yan; Alves, Marco G

    2017-06-01

    Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic phenotype and is involved in virtually all aspects of cellular function. It integrates not only nutrient and energy-sensing pathways but also actin cytoskeleton organization, in response to environmental cues including growth factors and cellular energy levels. These events are pivotal for spermatogenesis and determine the reproductive potential of males. Yet, the molecular mechanisms by which mTOR signaling acts in male reproductive system remain a matter of debate. Here, we review the current knowledge on physiological and molecular events mediated by mTOR in testis and testicular cells. In recent years, mTOR inhibition has been explored as a prime strategy to develop novel therapeutic approaches to treat cancer, cardiovascular disease, autoimmunity, and metabolic disorders. However, the physiological consequences of mTOR dysregulation and inhibition to male reproductive potential are still not fully understood. Compelling evidence suggests that mTOR is an arising regulator of male fertility and better understanding of this atypical protein kinase coordinated action in testis will provide insightful information concerning its biological significance in other tissues/organs. We also discuss why a new generation of mTOR inhibitors aiming to be used in clinical practice may also need to include an integrative view on the effects in male reproductive system.

  17. Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition.

    Marques-Ramos, Ana; Candeias, Marco M; Menezes, Juliane; Lacerda, Rafaela; Willcocks, Margaret; Teixeira, Alexandre; Locker, Nicolas; Romão, Luísa

    2017-11-01

    The mechanistic/mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that integrates cellular signals from the nutrient and energy status to act, namely, on the protein synthesis machinery. While major advances have emerged regarding the regulators and effects of the mTOR signaling pathway, little is known about the regulation of mTOR gene expression. Here, we show that the human mTOR transcript can be translated in a cap-independent manner, and that its 5' untranslated region (UTR) is a highly folded RNA scaffold capable of binding directly to the 40S ribosomal subunit. We further demonstrate that mTOR is able to bypass the cap requirement for translation both in normal and hypoxic conditions. Moreover, our data reveal that the cap-independent translation of mTOR is necessary for its ability to induce cell-cycle progression into S phase. These results suggest a novel regulatory mechanism for mTOR gene expression that integrates the global protein synthesis changes induced by translational inhibitory conditions. © 2017 Marques-Ramos et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  18. Distributed Performance Measurement and Usability Assessment of the Tor Anonymization Network

    Steffen Kunz

    2012-05-01

    Full Text Available While the Internet increasingly permeates everyday life of individuals around the world, it becomes crucial to prevent unauthorized collection and abuse of personalized information. Internet anonymization software such as Tor is an important instrument to protect online privacy. However, due to the performance overhead caused by Tor, many Internet users refrain from using it. This causes a negative impact on the overall privacy provided by Tor, since it depends on the size of the user community and availability of shared resources. Detailed measurements about the performance of Tor are crucial for solving this issue. This paper presents comparative experiments on Tor latency and throughput for surfing to 500 popular websites from several locations around the world during the period of 28 days. Furthermore, we compare these measurements to critical latency thresholds gathered from web usability research, including our own user studies. Our results indicate that without massive future optimizations of Tor performance, it is unlikely that a larger part of Internet users would adopt it for everyday usage. This leads to fewer resources available to the Tor community than theoretically possible, and increases the exposure of privacy-concerned individuals. Furthermore, this could lead to an adoption barrier of similar privacy-enhancing technologies for a Future Internet.

  19. Activation of the TOR Signalling Pathway by Glutamine Regulates Insect Fecundity.

    Zhai, Yifan; Sun, Zhongxiang; Zhang, Jianqing; Kang, Kui; Chen, Jie; Zhang, Wenqing

    2015-05-29

    The target of rapamycin (TOR) positively controls cell growth in response to nutrients such as amino acids. However, research on the specific nutrients sensed by TOR is limited. Glutamine (Gln), a particularly important amino acid involved in metabolism in organisms, is synthesised and catalysed exclusively by glutamine synthetase (GS), and our previous studies have shown that Gln may regulate fecundity in vivo levels of the brown planthopper (BPH) Nilaparvata lugens. Until now, it has remained unclear whether Gln activates or inhibits the TOR signalling pathway. Here, we performed the combined analyses of iTRAQ (isobaric tags for relative and absolute quantification) and DGE (tag-based digital gene expression) data in N. lugens at the protein and transcript levels after GS RNAi, and we found that 52 pathways overlap, including the TOR pathway. We further experimentally demonstrate that Gln activates the TOR pathway by promoting the serine/threonine protein kinase AKT and inhibiting the 5'AMP-activated protein kinase AMPK phosphorylation activity in the pest. Furthermore, TOR regulates the fecundity of N. lugens probably by mediating vitellogenin (Vg) expression. This work is the first report that Gln activates the TOR pathway in vivo.

  20. Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional Signals.

    Weisman, Ronit

    2016-10-01

    All organisms can respond to the availability of nutrients by regulating their metabolism, growth, and cell division. Central to the regulation of growth in response to nutrient availability is the target of rapamycin (TOR) signaling that is composed of two structurally distinct complexes: TOR complex 1 (TORC1) and TOR complex 2 (TORC2). The TOR genes were first identified in yeast as target of rapamycin, a natural product of a soil bacterium, which proved beneficial as an immunosuppressive and anticancer drug and is currently being tested for a handful of other pathological conditions including diabetes, neurodegeneration, and age-related diseases. Studies of the TOR pathway unraveled a complex growth-regulating network. TOR regulates nutrient uptake, transcription, protein synthesis and degradation, as well as metabolic pathways, in a coordinated manner that ensures that cells grow or cease growth in response to nutrient availability. The identification of specific signals and mechanisms that stimulate TOR signaling is an active and exciting field of research that has already identified nitrogen and amino acids as key regulators of TORC1 activity. The signals, as well as the cellular functions of TORC2, are far less well understood. Additional open questions in the field concern the relationships between TORC1 and TORC2, as well as the links with other nutrient-responsive pathways. Here I review the main features of TORC1 and TORC2, with a particular focus on yeasts as model organisms.

  1. Knockdown of TOR causing ovarian diapause in a genetically stable brachypterous strain of Nilaparvata lugens.

    Liu, Fangzhou; Li, Kaiyin; Cai, Wanlun; Zhao, Jing; Zou, Yulan; Hua, Hongxia

    2017-08-01

    Brown planthopper (BPH), Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is one of the most damaging pests of rice crops. BPH is a migratory insect with a delayed ovarian development in migrants classified as reproductive diapause. The molecular mechanism of reproductive diapause remains unclear, although we suspect it might be regulated by one or more nutrient signaling pathways. The target of rapamycin (TOR) pathway regulates cell growth in response to nutritional information, which raised a hypothesis that TOR mediates BPH reproductive diapause. We used a pure brachypterous strain (BS) and a predominantly macropterous strain (MS) to investigate the roles of NlTOR in BPH reproductive diapause. We found that NlTOR is expressed from the nymphal to adult stages, with a higher expression level of NlTOR in BS adults at 1, 2, and 4 days posteclosion than in MS at the same time points. Injection of dsNlTOR into BS nymphs resulted in the termination of BPH female ovary development and the retardation of nymph development. We infer that TOR signaling functions in BPH reproductive diapause by regulating the expression of NlFoxA and NlVitellogenin. © 2017 Wiley Periodicals, Inc.

  2. The evolution of the TOR pathway and its role in cancer.

    Beauchamp, E M; Platanias, L C

    2013-08-22

    The target of rapamycin (TOR) pathway is highly conserved among eukaryotes and has evolved to couple nutrient sensing to cellular growth. TOR is found in two distinct signaling complexes in cells, TOR complex 1 (TORC1) and TOR complex 2 (TORC2). These complexes are differentially regulated and act as effectors for the generation of signals that drive diverse cellular processes such as growth, proliferation, protein synthesis, rearrangement of the cytoskeleton, autophagy, metabolism and survival. Mammalian TOR (mTOR) is very important for development in embryos, while in adult organisms it is linked to aging and lifespan effects. In humans, the mTOR pathway is implicated in the tumorigenesis of multiple cancer types and its deregulation is associated with familial cancer syndromes. Because of its high biological relevance, different therapeutic strategies have been developed to target this signaling cascade, resulting in the emergence of unique pharmacological inhibitors that are either already approved for use in clinical oncology or currently under preclinical or clinical development. Multimodal treatment strategies that simultaneously target multiple nodes of the pathway and/or negative feedback regulatory loops may ultimately provide the best therapeutic advantage in targeting this pathway for the treatment of malignancies.

  3. Balancing act: matching growth with environment by the TOR signalling pathway.

    Henriques, Rossana; Bögre, László; Horváth, Beátrix; Magyar, Zoltán

    2014-06-01

    One of the most fundamental aspects of growth in plants is its plasticity in relation to fluctuating environmental conditions. Growth of meristematic cells relies predominantly on protein synthesis, one of the most energy-consuming activities in cells, and thus is tightly regulated in accordance with the available nutrient and energy supplies. The Target of Rapamycin (TOR) signalling pathway takes a central position in this regulation. The core of the TOR signalling pathway is conserved throughout evolution, and can be traced back to the last eukaryotic common ancestor. In plants, a single complex constitutes the TOR signalling pathway. Manipulating the components of the TOR complex in Arabidopsis highlighted its common role as a major regulator of protein synthesis and metabolism, that is also involved in other biological functions such as cell-wall integrity, regulation of cell proliferation, and cell size. TOR, as an integral part of the auxin signalling pathway, connects hormonal and nutrient pathways. Downstream of TOR, S6 kinase and the ribosomal S6 protein have been shown to mediate several of these responses, although there is evidence of other complex non-linear TOR signalling pathway structures. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  4. Muslim refugees in Southeast Asia, the Malaysian response.

    Dorall, R F

    1988-01-01

    This article surveys the arrivals of Muslim refugees from countries in Southeast Asia who have not only come to Malaysia for political refuge, but who have also stayed on, in many instances integrating into the local Muslim community. The author concludes that Burmese, Thai, and Filipino Muslim refugee-cum-migrants, and the estimated 500,000 illegal Indonesian migrant workers in East and Peninsular Malaysia make the presence of economic migrants in Malaysia's towns and rural sectors a far more pressing concern to Malaysians than that posed by the arrival of genuine political refugees. Only the Indonesians present in Malaysia are consistently termed by all parties as illegal migrants and some of them have been subjected to well-publicized deportation by the Malaysian immigration authorities. Sympathy for fellow-Muslims in distress explains Malaysia's open-door policy to Muslim refugees. The Koran specifically enjoins Muslims to assist Muslim refugees who have been persecuted by others. However, the necessity to maintain regional political and military alliances, principally as a bulwark against Communism, and the Malay--Non-Malay, Muslim--Non-Muslim dichotomy in Malaysia which almost evenly divides Malaysia's 16 million population into mutually antagonistic halves, results in any overt public policy in favor of Malays and Muslims to be immediately denounced by the other half of the population as a move against the Non-Malays and Non-Muslims. Without political and media attention, the refugees live wherever they can find work, as do hundreds of thousands of mainly Indonesian illegal migrant workers. They surreptitiously get their children admitted to public schools, and through bribery, can even get Malaysian identification papers. Malaysia is a relatively tranquil haven for Malaysia's Muslim refugees compared to their homelands, but their continued stay remains dependent on the ever-present struggle for more equitable sharing of political and economic power between

  5. Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells

    Ristic, Biljana; Bosnjak, Mihajlo; Arsikin, Katarina; Mircic, Aleksandar; Suzin-Zivkovic, Violeta; Bogdanovic, Andrija; Perovic, Vladimir; Martinovic, Tamara; Kravic-Stevovic, Tamara; Bumbasirevic, Vladimir; Trajkovic, Vladimir; Harhaji-Trajkovic, Ljubica

    2014-01-01

    We investigated if the antileukemic drug idarubicin induces autophagy, a process of programmed cellular self-digestion, in leukemic cell lines and primary leukemic cells. Transmission electron microscopy and acridine orange staining demonstrated the presence of autophagic vesicles and intracellular acidification, respectively, in idarubicin-treated REH leukemic cell line. Idarubicin increased punctuation/aggregation of microtubule-associated light chain 3B (LC3B), enhanced the conversion of LC3B-I to autophagosome-associated LC3B-II in the presence of proteolysis inhibitors, and promoted the degradation of the selective autophagic target p62, thus indicating the increase in autophagic flux. Idarubicin inhibited the phosphorylation of the main autophagy repressor mammalian target of rapamycin (mTOR) and its downstream target p70S6 kinase. The treatment with the mTOR activator leucine prevented idarubicin-mediated autophagy induction. Idarubicin-induced mTOR repression was associated with the activation of the mTOR inhibitor AMP-activated protein kinase and down-regulation of the mTOR activator Akt. The suppression of autophagy by pharmacological inhibitors or LC3B and beclin-1 genetic knockdown rescued REH cells from idarubicin-mediated oxidative stress, mitochondrial depolarization, caspase activation and apoptotic DNA fragmentation. Idarubicin also caused mTOR inhibition and cytotoxic autophagy in K562 leukemic cell line and leukocytes from chronic myeloid leukemia patients, but not healthy controls. By demonstrating mTOR-dependent cytotoxic autophagy in idarubicin-treated leukemic cells, our results warrant caution when considering combining idarubicin with autophagy inhibitors in leukemia therapy. - Highlights: • Idarubicin induces autophagy in leukemic cell lines and primary leukemic cells. • Idarubicin induces autophagy by inhibiting mTOR in leukemic cells. • mTOR suppression by idarubicin is associated with AMPK activation and Akt blockade.

  6. Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells

    Ristic, Biljana [Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr. Subotica 1, 11000 Belgrade (Serbia); Bosnjak, Mihajlo [Institute of Histology and Embryology, School of Medicine, University of Belgrade, Belgrade (Serbia); Arsikin, Katarina [Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr. Subotica 1, 11000 Belgrade (Serbia); Mircic, Aleksandar; Suzin-Zivkovic, Violeta [Institute of Histology and Embryology, School of Medicine, University of Belgrade, Belgrade (Serbia); Bogdanovic, Andrija [Clinic for Hematology, Clinical Centre of Serbia, School of Medicine, University of Belgrade, Belgrade (Serbia); Perovic, Vladimir [Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr. Subotica 1, 11000 Belgrade (Serbia); Martinovic, Tamara; Kravic-Stevovic, Tamara; Bumbasirevic, Vladimir [Institute of Histology and Embryology, School of Medicine, University of Belgrade, Belgrade (Serbia); Trajkovic, Vladimir, E-mail: vtrajkovic@med.bg.ac.rs [Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr. Subotica 1, 11000 Belgrade (Serbia); Harhaji-Trajkovic, Ljubica, E-mail: buajk@yahoo.com [Institute for Biological Research, University of Belgrade, Belgrade, Despot Stefan Blvd. 142, 11000 Belgrade (Serbia)

    2014-08-01

    We investigated if the antileukemic drug idarubicin induces autophagy, a process of programmed cellular self-digestion, in leukemic cell lines and primary leukemic cells. Transmission electron microscopy and acridine orange staining demonstrated the presence of autophagic vesicles and intracellular acidification, respectively, in idarubicin-treated REH leukemic cell line. Idarubicin increased punctuation/aggregation of microtubule-associated light chain 3B (LC3B), enhanced the conversion of LC3B-I to autophagosome-associated LC3B-II in the presence of proteolysis inhibitors, and promoted the degradation of the selective autophagic target p62, thus indicating the increase in autophagic flux. Idarubicin inhibited the phosphorylation of the main autophagy repressor mammalian target of rapamycin (mTOR) and its downstream target p70S6 kinase. The treatment with the mTOR activator leucine prevented idarubicin-mediated autophagy induction. Idarubicin-induced mTOR repression was associated with the activation of the mTOR inhibitor AMP-activated protein kinase and down-regulation of the mTOR activator Akt. The suppression of autophagy by pharmacological inhibitors or LC3B and beclin-1 genetic knockdown rescued REH cells from idarubicin-mediated oxidative stress, mitochondrial depolarization, caspase activation and apoptotic DNA fragmentation. Idarubicin also caused mTOR inhibition and cytotoxic autophagy in K562 leukemic cell line and leukocytes from chronic myeloid leukemia patients, but not healthy controls. By demonstrating mTOR-dependent cytotoxic autophagy in idarubicin-treated leukemic cells, our results warrant caution when considering combining idarubicin with autophagy inhibitors in leukemia therapy. - Highlights: • Idarubicin induces autophagy in leukemic cell lines and primary leukemic cells. • Idarubicin induces autophagy by inhibiting mTOR in leukemic cells. • mTOR suppression by idarubicin is associated with AMPK activation and Akt blockade.

  7. The TOR Pathway Is Involved in Adventitious Root Formation in Arabidopsis and Potato.

    Deng, Kexuan; Dong, Pan; Wang, Wanjing; Feng, Li; Xiong, Fangjie; Wang, Kai; Zhang, Shumin; Feng, Shun; Wang, Bangjun; Zhang, Jiankui; Ren, Maozhi

    2017-01-01

    In the agriculture industry, adventitious root formation is a core issue of plants asexual propagation. However, the underlying molecular mechanism of adventitious root formation is far beyond understanding. In present study we found that target of rapamycin (TOR) signaling plays a key role in adventitious root formation in potato and Arabidopsis . The core components of TOR complex including TOR, RAPTOR, and LST8 are highly conserved in potato, but the seedlings of potato are insensitive to rapamycin, implying FK506 Binding Protein 12 KD (FKBP12) lost the function to bridge the interaction of rapamycin and TOR in potato. To dissect TOR signaling in potato, the rapamycin hypersensitive potato plants (BP12-OE) were engineered by introducing yeast FKBP12 ( ScFKBP12 ) into potato. We found that rapamycin can significantly attenuate the capability of adventitious root formation in BP12-OE potatoes. KU63794 (KU, an active-site TOR inhibitor) combined with rapamycin can more significantly suppress adventitious root formation of BP12-OE potato than the single treatments, such as KU63794 or rapamycin, indicating its synergistic inhibitory effects on potato adventitious root formation. Furthermore, RNA-seq data showed that many genes associated with auxin signaling pathway were altered when BP12-OE potato seedlings were treated with rapamycin + KU, suggesting that TOR may play a major role in adventitious root formation via auxin signaling. The auxin receptor mutant tir1 was sensitive to TOR inhibitors and the double and quadruple mutants including tir1afb2, tir1afb3 , and tir1afb1afb2afb3 displayed more sensitive to asTORis than single mutant tir1 . Consistently, overexpression of AtTIR1 in Arabidopsis and potato can partially overcome the inhibitory effect of asTORis and promote adventitious root formation under asTORis treatments. These observations suggest that TOR signaling regulates adventitious root formation by mediating auxin signaling in Arabidopsis and potato.

  8. Molecular insights into the evolutionary pathway of Vibrio cholerae O1 atypical El Tor variants.

    Kim, Eun Jin; Lee, Dokyung; Moon, Se Hoon; Lee, Chan Hee; Kim, Sang Jun; Lee, Jae Hyun; Kim, Jae Ouk; Song, Manki; Das, Bhabatosh; Clemens, John D; Pape, Jean William; Nair, G Balakrish; Kim, Dong Wook

    2014-09-01

    Pandemic V. cholerae strains in the O1 serogroup have 2 biotypes: classical and El Tor. The classical biotype strains of the sixth pandemic, which encode the classical type cholera toxin (CT), have been replaced by El Tor biotype strains of the seventh pandemic. The prototype El Tor strains that produce biotype-specific cholera toxin are being replaced by atypical El Tor variants that harbor classical cholera toxin. Atypical El Tor strains are categorized into 2 groups, Wave 2 and Wave 3 strains, based on genomic variations and the CTX phage that they harbor. Whole-genome analysis of V. cholerae strains in the seventh cholera pandemic has demonstrated gradual changes in the genome of prototype and atypical El Tor strains, indicating that atypical strains arose from the prototype strains by replacing the CTX phages. We examined the molecular mechanisms that effected the emergence of El Tor strains with classical cholera toxin-carrying phage. We isolated an intermediary V. cholerae strain that carried two different CTX phages that encode El Tor and classical cholera toxin, respectively. We show here that the intermediary strain can be converted into various Wave 2 strains and can act as the source of the novel mosaic CTX phages. These results imply that the Wave 2 and Wave 3 strains may have been generated from such intermediary strains in nature. Prototype El Tor strains can become Wave 3 strains by excision of CTX-1 and re-equipping with the new CTX phages. Our data suggest that inter-chromosomal recombination between 2 types of CTX phages is possible when a host bacterial cell is infected by multiple CTX phages. Our study also provides molecular insights into population changes in V. cholerae in the absence of significant changes to the genome but by replacement of the CTX prophage that they harbor.

  9. TOR-inhibitor insensitive-1 (TRIN1) regulates cotyledons greening in Arabidopsis.

    Li, Linxuan; Song, Yun; Wang, Kai; Dong, Pan; Zhang, Xueyan; Li, Fuguang; Li, Zhengguo; Ren, Maozhi

    2015-01-01

    Target of Rapamycin (TOR) is an eukaryotic protein kinase and evolutionally conserved from the last eukaryotic common ancestor (LECA) to humans. The growing evidences have shown that TOR signaling acts as a central controller of cell growth and development. The downstream effectors of TOR have been well-identified in yeast and animals by using the immunosuppression agent rapamycin. However, less is known about TOR in plants. This is largely due to the fact that plants are insensitive to rapamycin. In this study, AZD8055 (AZD), the novel ATP-competitive inhibitor of TOR, was employed to decipher the downstream effectors of TOR in Arabidopsis. One AZD insensitive mutant, T O R - i nhibitor i n sensitive- 1 (trin1), was screened from 10,000 EMS-induced mutation seeds. The cotyledons of trin1 can turn green when its seeds were germinated on ½ MS medium supplemented with 2 μM AZD, whereas the cotyledons greening of wild-type (WT) can be completely blocked at this concentration. Through genetic mapping, TRIN1 was mapped onto the long arm of chromosome 2, between markers SGCSNP26 and MI277. Positional cloning revealed that TRIN1 was an allele of ABI4, which encoded an ABA-regulated AP2 domain transcription factor. Plants containing P35S::TRIN1 or P35S::TRIN1-GUS were hypersensitive to AZD treatment and displayed the opposite phenotype observed in trin1. Importantly, GUS signaling was significantly enhanced in P35S::TRIN1-GUS transgenic plants in response to AZD treatment, indicating that suppression of TOR resulted in the accumulation of TRIN1. These observations revealed that TOR controlled seed-to-seedling transition by negatively regulating the stability of TRIN1 in Arabidopsis. For the first time, TRIN1, the downstream effector of TOR signaling, was identified through a chemical genetics approach.

  10. Evaluating effectiveness and safety toward electronic cigarette among Malaysian vapers: One-month observational study

    Azizur Rahman

    2016-01-01

    Conclusion: A month follow-up showed a good smoking cessation rate among Malaysian vapers mainly in single users, whereas less number of quitters but the high reduction in tobacco cigarette consumption observed in dual users without any harmful effects. Furthermore, extended period studies are warranted to confirm its long-term safety and effectiveness among different Malaysian population.

  11. Techniques of Teaching Arabic as a Foreign Language through Constructivist Paradigm: Malaysian Perspective

    Faryadi, Qais

    2007-01-01

    This analysis discusses the constructivist paradigm of teaching Arabic as a foreign language in Malaysian settings. This review examines the role of interactive multimedia in enhancing the chalk and talk methods of teaching Arabic in Malaysian schools. This paper also investigates the importance of Arabic Language in Malaysia. Furthermore, the…

  12. Property types diversification strategy of Malaysian real estate investment trust (M-REITs

    Ping Tiong Chai

    2016-01-01

    Full Text Available The aim of this paper is to review the property types diversification strategy of Malaysian REITs. Previous study has found that Malaysian REITs received poor response form investors both local and international. Furthermore, the underperformance of Malaysian REITs was linked to the characteristics of REITs’ property types and REITs’ portfolio influenced its financial performance. The lack of local study on both of these determinants of influence on performance of Malaysian REITs is a research gap, which needs to be explored that can provide more insight of it. This study showed that the property types such as office space, commercial lot, industrial, hotel and specialized property type are the important determinants, which can influence the performance of REITs. The study comprised of REITs data from 2010 until 2014, and through Multiple Regression Analysis (MRA reveals there is little influence of property types diversification strategy toward Malaysian REITs’ performance. Nevertheless, by employ correlation analysis between each of the five property types with expected return and dividend yield, this study shows Malaysian REITs’ performance of dividend yield(DY has a positive correlation value with commercial lot property type and Malaysian REITs’ performance of expected return(ER have a highest positive correlation value with industrial property types. Also, this study suggests that property type diversification play a significant role in Malaysia REITs. Other determinants such as location of property, market capitalization and REITs’ quality of advisory style that might influence the diversification strategy and financial performance of Malaysian REITs.

  13. ERP and Knowledge Management Integration: The Case of Malaysian Business Firms

    Supramaniam, Mahadevan; Kuppusamy, Mudiarasan

    2010-01-01

    In order to compete in a global environment, Malaysian business firms need to improve their products and services through best practices. This paper aims to investigate the critical success factors to adopt Enterprise Resource Planning (ERP) with knowledge management (KM) strategies among Malaysian business firms. In order to achieve the research…

  14. Teachers' Perception of Mobile Edutainment for Special Needs Learners: The Malaysian Case

    Mohd Yusof, Anuar; Daniel, Esther Gnanamalar Sarojini; Low, Wah Yun; Ab. Aziz, Kamarulzaman

    2014-01-01

    Study of Malaysian adoption of mobile learning (m-learning) is still in the early stages. However, there are numerous researchers in the country exploring the potential and application of m-learning in the Malaysian education system, including special education. A key question is whether teachers are prepared to incorporate mobile technology as…

  15. Managerial Coaches, Are They Ready? The Case of Malaysian Telecommunications Industry

    Chong, Chin Wei; Yuen, Yee Yen; Tan, Booi Chen; Zarim, Zainal Abu; Hamid, Norhasniza Abdul

    2016-01-01

    Purpose: This paper aims to identify the key competencies managerial coaches have and examine the significant competencies that affect coaching effectiveness in the Malaysian telecommunications industry. Design/Methodology/Approach: The unit of analysis was individual managerial coaches who were working in the Malaysian telecommunications…

  16. Online Activities of Urban Malaysian Adolescents: Report of a Pilot Study

    Tan, Kok Eng; Yen Abdullah, Melissa Ng Lee; Guan Saw, Kim

    2012-01-01

    The literacy practices of many communities today show new ways of meaning making in the contemporary, technological and digital culture. A number of Malaysian adolescents belong to this culture. This pilot study reports the preliminary findings of a larger study aimed at describing the online activities of Malaysian adolescents. Fifty-four…

  17. Intercultural Communication and the Decision-Making Process: Americans and Malaysians in a Cooperative University Setting.

    Wilhelm, Kim Hughes

    A study investigated the application of Geert Hofstede's theory of cultural dimensions in management to the situation of Malaysian (n=8) and American (n=4) instructors in implementing a new English-as-a-Second-Language curriculum in Malaysia. American and Malaysian cultures are compared on four dimensions: social differentiation by gender; desire…

  18. Are Modal Auxiliaries in Malaysian English Language Textbooks in Line with Their Usage in Real Language?

    Khojasteh, Laleh; Kafipour, Reza

    2012-01-01

    Based on the discrepancies found in many Malaysian English language textbooks, a detailed analysis on the way modal auxiliary verb forms and their semantic functions were introduced and presented in texts and exercises in five Malaysian textbooks was done. For that to be achieved, a qualitative page-by-page content analysis was applied. From the…

  19. "All Abroad": Malaysians' Reasons for Seeking an Overseas-Based Doctorate

    Tagg, Brendon

    2014-01-01

    This article examines the process by which nine junior Malaysian academics came to complete doctoral degrees in non-Malaysian universities. It expands the scope and refines the focus of an existing study that considered international students' experiences in New Zealand. Part of the motivation for the current study was the researcher's recognition…

  20. Impact of Antecedent Factors on Collaborative Technologies Usage among Academic Researchers in Malaysian Research Universities

    Mohd Daud, Norzaidi; Zakaria, Halimi

    2017-01-01

    Purpose: The purpose of this paper is to investigate the impact of antecedent factors on collaborative technologies usage among academic researchers in Malaysian research universities. Design/methodology/approach: Data analysis was conducted on data collected from 156 academic researchers from five Malaysian research universities. This study…

  1. The Malaysian English Language Competency Dilemma: Recovering Lost Grounds through MUET.

    Chan, Swee Heng; Wong, Bee Eng

    2002-01-01

    Provides insights into the Malaysian English language policy, required standards, and testing in language use in Malaysian tertiary institutions. Gives information about backwash effects in particular about institutional programs related to the teaching of English as a Second Language. (Author/VWL)

  2. Factors for analysing and improving performance of R&D in Malaysian universities

    Ramli, Mohammad Shakir; de Boer, S.J.; de Bruijn, E.J.

    2004-01-01

    This paper presents a model for analysing and improving performance of R&D in Malaysian universities. There are various general models for R&D analysis, but none is specific for improving the performance of R&D in Malaysian universities. This research attempts to fill a gap in the body of knowledge

  3. Transient activation of mTOR following forced treadmill exercise in rats

    Elfving, Betina; Christensen, Tina; Ratner, Cecilia

    2013-01-01

    , while the induction of neurogenesis requires signaling through the VEGF receptor, Flk-1 (VEGFR-2). VEGF expression is believed to be regulated by two distinct mTOR (mammalian Target of Rapamycin)-containing multiprotein complexes mTORC1 and mTORC2, respectively. This study was initiated to investigate...... of mTOR was regulated after a single bout of exercise. In conclusion, the effect of treadmill exercise on the VEGF system is acute rather than chronic and there is a transient activation of mTOR. More studies are needed to understand whether this could be beneficial in the treatment of neuropsychiatric...

  4. Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.

    Harraz, M M; Tyagi, R; Cortés, P; Snyder, S H

    2016-03-01

    As traditional antidepressants act only after weeks/months, the discovery that ketamine, an antagonist of glutamate/N-methyl-D-aspartate (NMDA) receptors, elicits antidepressant actions in hours has been transformative. Its mechanism of action has been elusive, though enhanced mammalian target of rapamycin (mTOR) signaling is a major feature. We report a novel signaling pathway wherein NMDA receptor activation stimulates generation of nitric oxide (NO), which S-nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitrosylated GAPDH complexes with the ubiquitin-E3-ligase Siah1 and Rheb, a small G protein that activates mTOR. Siah1 degrades Rheb leading to reduced mTOR signaling, while ketamine, conversely, stabilizes Rheb that enhances mTOR signaling. Drugs selectively targeting components of this pathway may offer novel approaches to the treatment of depression.

  5. El Tor hemolysin of Vibrio cholerae O1 forms channels in planar lipid bilayer membranes.

    Ikigai, H; Ono, T; Iwata, M; Nakae, T; Shimamura, T

    1997-05-15

    We investigated the channel formation by El Tor hemolysin (molecular mass, 65 kDa) of Vibrio cholerae O1 biotype El Tor in planar lipid bilayers. The El Tor hemolysin channel exhibited asymmetric and hyperbolic membrane current with increasing membrane potential, meaning that the channel is voltage dependent. The zero-current membrane potential measured in KCI solution showed that permeability ratio PK+/PCl- was 0.16, indicating that the channel is 6-fold more anion selective over cation. The hemolysin channel frequently flickered in the presence of divalent cations, suggesting that the channel spontaneously opens and closes. These data imply that the El Tor hemolysin damages target cells by the formation of transmembrane channels and, consequently, is the cause of osmotic cytolysis.

  6. Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.

    Peterson, Emily A; Boezio, Alessandro A; Andrews, Paul S; Boezio, Christiane M; Bush, Tammy L; Cheng, Alan C; Choquette, Deborah; Coats, James R; Colletti, Adria E; Copeland, Katrina W; DuPont, Michelle; Graceffa, Russell; Grubinska, Barbara; Kim, Joseph L; Lewis, Richard T; Liu, Jingzhou; Mullady, Erin L; Potashman, Michele H; Romero, Karina; Shaffer, Paul L; Stanton, Mary K; Stellwagen, John C; Teffera, Yohannes; Yi, Shuyan; Cai, Ti; La, Daniel S

    2012-08-01

    mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to discover ATP-competitive mTOR inhibitors that demonstrate improved pharmacokinetic properties and selectivity compared to our previous leads. Through targeted SAR and structure-guided design, new imidazopyridine and imidazopyridazine scaffolds were identified that demonstrated superior inhibition of mTOR in cellular assays, selectivity over the closely related PIKK family and improved in vivo clearance over our previously reported benzimidazole series. Copyright © 2012. Published by Elsevier Ltd.

  7. PREDICTION OF THE COURSE OF OSTEOARTHROSIS FROM mTOR (MAMMALIAN TARGET OF RAPAMYCIN GENE EXPRESSION

    E V Chetina

    2012-01-01

    Results. Analysis of gene expression in the outpatients with OA identified two subgroups: in one subgroup (n = 13 mTOR expression was considerably much less than that in the control group; the expression of ATG1 and p21 did not differ greatly from the control and that of caspase 3 and TNF-α was significantly higher. The other outpatients (n = 20 and all the examined patients needing endoprosthetic replacement were ascertained to have a higher gene expression of mTOR, ATG1, p21, caspase 3, and TNF-α than in the control group. Before endoprosthetic replacement, severe joint destruction in patients with OA was associated with enhanced gene expression of mTOR, ATG1, p21, and caspase 3. Conclusion. In early-stage disease, increased mTOR gene expression may serve as a prognostic marker of the severity of the disease and articular cartilage destruction.

  8. mTOR as a multifunctional therapeutic target in HIV infection

    Nicoletti, Ferdinando; Fagone, Paolo; Meroni, PierLuigi

    2011-01-01

    Patients undergoing long-term highly active antiretroviral therapy treatment are probably at a higher risk of various HIV-related complications. Hyperactivation of The mammalian target of rapamycin (mTOR) has been found to contribute to dysregulated apoptosis and autophagy which determine CD4(+)-T......-cell loss, impaired function of innate immunity and development of neurocognitive disorders. Dysregulated mTOR activation has also been shown to play a key part in the development of nephropathy and in the pathogenesis of HIV-associated malignancies. These studies strongly support a multifunctional key role...... for mTOR in the pathogenesis of HIV-related disorders and suggest that specific mTOR inhibitors could represent a novel approach for the prevention and treatment of these pathologies....

  9. Regulation of the mTOR Pathway by a Novel Rheb Binding Protein BNIP3

    Guan, Kun-Liang

    2008-01-01

    .... We demonstrate that BNIP3 plays a critical role in hypoxia-induced mTOR inhibition. Furthermore we found that BNIP3 itself has a growth inhibitory activity and inactivation of BNIP3 promotes cell growth...

  10. Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy.

    Wander, Seth A

    2011-04-01

    Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly activated in cancers. While hypoxia, nutrient deprivation, and DNA damage restrain mTORC1 activity, multiple genetic events constitutively activate mTOR in cancers. Here we provide a brief overview of the signaling pathways up- and downstream of mTORC1 and -2, and discuss the insights into therapeutic anticancer targets - both those that have been tried in the clinic with limited success and those currently under clinical development - that knowledge of these pathways gives us.

  11. [Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy--
AKT/m-TOR Pathway and Resistance to Cancer Therapy].

    Spirina, Liudmila V; Kondakova, Irina V; Tarasenko, Natalia V; Slonimskaya, Elena M; Usynin, Evgeny A; Gorbunov, Alexey K; Yurmazov, Zahar A; Chigevskaya, Svetlana Yu

    2018-01-20

    Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy.

  12. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

    Kathrin Thedieck

    Full Text Available TOR (Target of Rapamycin is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two functionally and structurally distinct multiprotein complexes termed TOR complex 1 (TORC1 and TOR complex 2 (TORC2. In the present study, we developed a two-dimensional liquid chromatography tandem mass spectrometry (2D LC-MS/MS based proteomic strategy to identify new mammalian TOR (mTOR binding proteins. We report the identification of Proline-rich Akt substrate (PRAS40 and the hypothetical protein Q6MZQ0/FLJ14213/CAE45978 as new mTOR binding proteins. PRAS40 binds mTORC1 via Raptor, and is an mTOR phosphorylation substrate. PRAS40 inhibits mTORC1 autophosphorylation and mTORC1 kinase activity toward eIF-4E binding protein (4E-BP and PRAS40 itself. HeLa cells in which PRAS40 was knocked down were protected against induction of apoptosis by TNFalpha and cycloheximide. Rapamycin failed to mimic the pro-apoptotic effect of PRAS40, suggesting that PRAS40 mediates apoptosis independently of its inhibitory effect on mTORC1. Q6MZQ0 is structurally similar to proline rich protein 5 (PRR5 and was therefore named PRR5-Like (PRR5L. PRR5L binds specifically to mTORC2, via Rictor and/or SIN1. Unlike other mTORC2 members, PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knock down of tuberous sclerosis complex 1 (TSC1 and TSC2. Hyperactivation of mTOR by TSC1/2 knock down enhanced apoptosis whereas PRR5L knock down reduced apoptosis. PRR5L knock down reduced apoptosis also in mTORC2 deficient cells. The above suggests that mTORC2-dissociated PRR5L may promote apoptosis when mTOR is hyperactive. Thus, PRAS40 and PRR5L are novel mTOR-associated proteins that control the balance between cell growth and cell death.

  13. Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom

    Heitman Joseph

    2010-09-01

    Full Text Available Abstract Background The nutrient-sensing Tor pathway governs cell growth and is conserved in nearly all eukaryotic organisms from unicellular yeasts to multicellular organisms, including humans. Tor is the target of the immunosuppressive drug rapamycin, which in complex with the prolyl isomerase FKBP12 inhibits Tor functions. Rapamycin is a gold standard drug for organ transplant recipients that was approved by the FDA in 1999 and is finding additional clinical indications as a chemotherapeutic and antiproliferative agent. Capitalizing on the plethora of recently sequenced genomes we have conducted comparative genomic studies to annotate the Tor pathway throughout the fungal kingdom and related unicellular opisthokonts, including Monosiga brevicollis, Salpingoeca rosetta, and Capsaspora owczarzaki. Results Interestingly, the Tor signaling cascade is absent in three microsporidian species with available genome sequences, the only known instance of a eukaryotic group lacking this conserved pathway. The microsporidia are obligate intracellular pathogens with highly reduced genomes, and we hypothesize that they lost the Tor pathway as they adapted and streamlined their genomes for intracellular growth in a nutrient-rich environment. Two TOR paralogs are present in several fungal species as a result of either a whole genome duplication or independent gene/segmental duplication events. One such event was identified in the amphibian pathogen Batrachochytrium dendrobatidis, a chytrid responsible for worldwide global amphibian declines and extinctions. Conclusions The repeated independent duplications of the TOR gene in the fungal kingdom might reflect selective pressure acting upon this kinase that populates two proteinaceous complexes with different cellular roles. These comparative genomic analyses illustrate the evolutionary trajectory of a central nutrient-sensing cascade that enables diverse eukaryotic organisms to respond to their natural

  14. Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

    Tang, Guomei; Gudsnuk, Kathryn; Kuo, Sheng-Han; Cotrina, Marisa L.; Rosoklija, Gorazd; Sosunov, Alexander; Sonders, Mark S.; Kanter, Ellen; Castagna, Candace; Yamamoto, Ai; Yue, Zhenyu; Arancio, Ottavio; Peterson, Bradley S.; Champagne, Frances; Dwork, Andrew J.

    2014-01-01

    Developmental alterations of excitatory synapses are implicated in autism spectrum disorders (ASDs). Here, we report increased dendritic spine density with reduced developmental spine pruning in layer V pyramidal neurons in postmortem ASD temporal lobe. These spine deficits correlate with hyperactivated mTOR and impaired autophagy. In Tsc2+/- ASD mice where mTOR is constitutively overactive, we observed postnatal spine pruning defects, blockade of autophagy, and ASD-like social...

  15. Blocking mammalian target of rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury.

    Wang, Xiaoping; Li, Xiaojia; Huang, Bin; Ma, Shuai

    2016-01-01

    Spinal cord injury (SCI) is an extremely serious type of physical trauma observed in clinics. Neuropathic pain resulting from SCI has a lasting and significant impact on most aspects of daily life. Thus, a better understanding of the molecular pathways responsible for the cause of neuropathic pain observed in SCI is important to develop effective therapeutic agents and treatment strategies. Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that is well known for its critical roles in regulating protein synthesis and growth. Furthermore, compelling evidence supports the notion that widespread dysregulation of mTOR and its downstream pathways are involved in neuropathic pain. Thus, in this study we specifically examined the underlying mechanisms by which mTOR and its signaling pathways are involved in SCI-evoked neuropathic pain in a rat model. Overall, we demonstrated that SCI increased the protein expression of p-mTOR, and mTORmediated- phosphorylation of 4E-binding protein 4 (4E-BP1) and p70 ribosomal S6 protein kinase 1 (S6K1) in the superficial dorsal horn of the spinal cord. Also, we showed that blocking spinal mTOR by intrathecal injection of rapamycin significantly inhibited pain responses induced by mechanical and thermal stimulation. In addition, blocking spinal phosphatidylinositide 3-kinase (p-PI3K) pathway significantly attenuated activities of p-mTOR pathways as well as mechanical and thermal hyperalgesia in SCI rats. Moreover, blocking mTOR and PI3K decreased the enhanced levels of substance P and calcitonin gene-related peptide (CGRP) in the dorsal horn of SCI rats. We revealed specific signaling pathways leading to SCI-evoked neuropathic pain, including the activation of PI3K, mTOR and its downstream signaling pathways. Targeting one or more of these signaling molecules may present new opportunities for treatment and management of neuropathic pain often observed in patients with SCI.

  16. Characterization of mTOR-Responsive Truncated mRNAs in Cell Proliferation

    2017-07-01

    These findings identify a previously uncharacterized role for mTOR in modulating 3’- UTR length of mRNAs by alternative polyadenylation ( APA ). Another...outcome of APA in the mTOR-activated transcriptome is an early termination of mRNA transcription to produce truncated mRNAs with polyadenylation in...for exhaustive analysis of Alternative cleavage and polyadenylation ( APA ) events (Figure 1). In IntMAP, first the position of multiple

  17. TOR Signaling Promotes Accumulation of BZR1 to Balance Growth with Carbon Availability in Arabidopsis.

    Zhang, Zhenzhen; Zhu, Jia-Ying; Roh, Jeehee; Marchive, Chloé; Kim, Seong-Ki; Meyer, Christian; Sun, Yu; Wang, Wenfei; Wang, Zhi-Yong

    2016-07-25

    For maintenance of cellular homeostasis, the actions of growth-promoting hormones must be attenuated when nutrient and energy become limiting. The molecular mechanisms that coordinate hormone-dependent growth responses with nutrient availability remain poorly understood in plants [1, 2]. The target of rapamycin (TOR) kinase is an evolutionarily conserved master regulator that integrates nutrient and energy signaling to regulate growth and homeostasis in both animals and plants [3-7]. Here, we show that sugar signaling through TOR controls the accumulation of the brassinosteroid (BR)-signaling transcription factor BZR1, which is essential for growth promotion by multiple hormonal and environmental signals [8-11]. Starvation, caused by shifting of light-grown Arabidopsis seedlings into darkness, as well as inhibition of TOR by inducible RNAi, led to plant growth arrest and reduced expression of BR-responsive genes. The growth arrest caused by TOR inactivation was partially recovered by BR treatment and the gain-of-function mutation bzr1-1D, which causes accumulation of active forms of BZR1 [12]. Exogenous sugar promoted BZR1 accumulation and seedling growth, but such sugar effects were largely abolished by inactivation of TOR, whereas the effect of TOR inactivation on BZR1 degradation is abolished by inhibition of autophagy and by the bzr1-1D mutation. These results indicate that cellular starvation leads sequentially to TOR inactivation, autophagy, and BZR1 degradation. Such regulation of BZR1 accumulation by glucose-TOR signaling allows carbon availability to control the growth promotion hormonal programs, ensuring supply-demand balance in plant growth. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Delayed Recovery of Skeletal Muscle Mass following Hindlimb Immobilization in mTOR Heterozygous Mice

    Lang, Susan M.; Kazi, Abid A.; Hong-Brown, Ly; Lang, Charles H.

    2012-01-01

    The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/-) mice, would exaggerate the changes in protein synthesis and degradation observed during hindlimb immobilization as well as impair normal muscle regrowth during the recovery period. Atrophy was produced by unilateral hindlimb immobilization and data compared to the contralateral gastrocnemius. In wild-type (WT) mice, the gradual loss of muscle mass plateaued by day 7. This response was associated ...

  19. mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment.

    Jahrling, Jordan B; Lin, Ai-Ling; DeRosa, Nicholas; Hussong, Stacy A; Van Skike, Candice E; Girotti, Milena; Javors, Martin; Zhao, Qingwei; Maslin, Leigh Ann; Asmis, Reto; Galvan, Veronica

    2018-01-01

    We recently showed that mTOR attenuation blocks progression and abrogates established cognitive deficits in Alzheimer's disease (AD) mouse models. These outcomes were associated with the restoration of cerebral blood flow (CBF) and brain vascular density (BVD) resulting from relief of mTOR inhibition of NO release. Recent reports suggested a role of mTOR in atherosclerosis. Because mTOR drives aging and vascular dysfunction is a universal feature of aging, we hypothesized that mTOR may contribute to brain vascular and cognitive dysfunction associated with atherosclerosis. We measured CBF, BVD, cognitive function, markers of inflammation, and parameters of cardiovascular disease in LDLR -/- mice fed maintenance or high-fat diet ± rapamycin. Cardiovascular pathologies were proportional to severity of brain vascular dysfunction. Aortic atheromas were reduced, CBF and BVD were restored, and cognitive dysfunction was attenuated potentially through reduction in systemic and brain inflammation following chronic mTOR attenuation. Our studies suggest that mTOR regulates vascular integrity and function and that mTOR attenuation may restore neurovascular function and cardiovascular health. Together with our previous studies in AD models, our data suggest mTOR-driven vascular damage may be a mechanism shared by age-associated neurological diseases. Therefore, mTOR attenuation may have promise for treatment of cognitive impairment in atherosclerosis.

  20. Dosimetry audits and intercomparisons in radiotherapy: A Malaysian profile

    M. Noor, Noramaliza; Nisbet, A.; Hussein, M.; Chu S, Sarene; Kadni, T.; Abdullah, N.; Bradley, D. A.

    2017-11-01

    Quality audits and intercomparisons are important in ensuring control of processes in any system of endeavour. Present interest is in control of dosimetry in teletherapy, there being a need to assess the extent to which there is consistent radiation dose delivery to the patient. In this study we review significant factors that impact upon radiotherapy dosimetry, focusing upon the example situation of radiotherapy delivery in Malaysia, examining existing literature in support of such efforts. A number of recommendations are made to provide for increased quality assurance and control. In addition to this study, the first level of intercomparison audit i.e. measuring beam output under reference conditions at eight selected Malaysian radiotherapy centres is checked; use being made of 9 μm core diameter Ge-doped silica fibres (Ge-9 μm). The results of Malaysian Secondary Standard Dosimetry Laboratory (SSDL) participation in the IAEA/WHO TLD postal dose audit services during the period between 2011 and 2015 will also been discussed. In conclusion, following review of the development of dosimetry audits and the conduct of one such exercise in Malaysia, it is apparent that regular periodic radiotherapy audits and intercomparison programmes should be strongly supported and implemented worldwide. The programmes to-date demonstrate these to be a good indicator of errors and of consistency between centres. A total of ei+ght beams have been checked in eight Malaysian radiotherapy centres. One out of the eight beams checked produced an unacceptable deviation; this was found to be due to unfamiliarity with the irradiation procedures. Prior to a repeat measurement, the mean ratio of measured to quoted dose was found to be 0.99 with standard deviation of 3%. Subsequent to the repeat measurement, the mean distribution was 1.00, and the standard deviation was 1.3%.

  1. Characteristics of Malaysian coals with their pyrolysis and gasification behaviour

    Nor Fadzilah Othman; Mohd Hariffin Bosrooh; Kamsani Abdul Majid

    2010-01-01

    This study was conducted since comprehensive study on the gasification behaviour of Malaysian coals is still lacking. Coals were characterised using heating value determination, proximate analysis, ultimate analysis and ash analysis. Pyrolysis process was investigated using thermogravimetric analyser. While, atmospheric bubbling fluidized bed gasifier was used to investigate the gasification behaviour. Three Malaysian coals, Merit Pila, Mukah Balingian, Silantek; and Australian coal, Hunter Valley coals were used in this study. Thermal degradation of four coal samples were performed, which involved weight loss profile and derivative thermogravimetric (DTG) curves. The kinetic parameters, such as maximum reactivity value, R max , Activation Energy, E a and Arrhenius constant, ln R o for each coal were determined using Arrhenius Equation. Merit Pila coal shows the highest maximum reactivity among other Malaysian coals. E a is the highest for Merit Pila coal (166.81kJmol -1 ) followed with Mukah Balingian (101.15 kJmol -1 ), Hunter Valley (96.45 kJmol -1 ) and Silantek (75.23 kJmol -1 ) coals. This finding indicates direct correlation of lower rank coal with higher E a . Merit Pila coal was studied in detail using atmospheric bubbling fluidized bed gasifier. Different variables such as equivalence ratio (ER) and gasifying agents were used. The highest H 2 proportion (38.3 mol.%) in the producer gas was reached at 715 degree Celsius and ER=0.277 where the maximization of LHV pg (5.56 MJ/Nm 3 ) was also detected. ER and addition of steam had shown significant contributions to the producer gas compositions and LHV pg . (author)

  2. A perspective study on green cleaning for Malaysian public hospital

    Ramli, N. A.; Zawawi, E. M.; Arif, N. R. M.; Mahbob, N. S.; Sulaiman, Z.; Zainol, N. N.

    2018-02-01

    Cleaning being a major contributor to the operations and maintenance expenditure and also Indoor Environmental Quality (IEQ) issues. Improper and ineffective cleaning can harm the environment and poses greatest risk to health. The use of traditional cleaning products presents a variety of human health and ecological concerns; and may contribute to poor IEQ. As an effort to reduce the issue of operations and maintenance costs and IEQ issues in a building, it is important to establish a green cleaning programme to ensure that the buildings are cleaned in a green way. Numbers of scholars has pointed out the factors which had prevented the green cleaning implementation in hospital buildings. Nonetheless, the significance of these factors has yet to be practically explored in the Malaysian context. Hence, the aim of the paper is to identify the most critical factor that prevents the implementation of green cleaning in Malaysian hospital building. A questionnaire survey and personal communication (i.e. interview) was conducted which involved two groups of respondents. They are the hospital maintenance staff (Cleansing Service Department) and cleaning contractors. Frequency and criticality index calculations have been used to rank these factors according to the level of importance. The result showed that an “unclear components and requirements of green cleaning” indicated as the most critical factor that prevent the implementation of green cleaning in Malaysian hospital building. In the concern for a successful implementation of green cleaning, it is hope that the findings of these studies can be enlightenment to the cleaning contractors as well as the hospital maintenance management team in Malaysia.

  3. Journal of Genetics | Indian Academy of Sciences

    ... Journal of Genetics; Volume 88; Issue 3. Population distribution of 45S and 5S rDNA in golden mahseer, Tor putitora: population-specific FISH marker. Mamta Singh Ravindra Kumar N. S. Nagpure Basdeo Kushwaha Indra Mani U. K. Chauhan W. S. Lakra. Research Article Volume 88 Issue 3 December 2009 pp 315-320 ...

  4. Journal of Genetics | Indian Academy of Sciences

    Home; Journals; Journal of Genetics. Ravindra Kumar. Articles written in Journal of Genetics. Volume 88 Issue 3 December 2009 pp 315-320 Research Article. Population distribution of 45S and 5S rDNA in golden mahseer, Tor putitora: population-specific FISH marker · Mamta Singh Ravindra Kumar N. S. Nagpure Basdeo ...

  5. EVALUATING GENDER DIFFERENCES IN THE COMPLAINT BEHAVIOR OF MALAYSIAN CONSUMERS

    Nelson Oly Ndubisi

    2007-01-01

    Full Text Available The aim of this paper is to investigate whether male and female Malaysian consumers differ in their dissatisfaction complaint behavior and its aftermath. The study examines the moderation effect of gender in the relationship between public complaint behavior, private complaint behavior and customer defection. Data for the study was collected from 218 randomly selected customers of retail banks in Malaysia. The results show that public and private complaints are significantly associated with defection. These findings are generic across sex-type. Theoretical and managerial implications of the findings are discussed.

  6. Perceptions of Trade Credit Insurance Value : Malaysian Evidence

    Wong, Benny Weng Hong

    2013-01-01

    Trade credit insurance (“TCI”) is a subject unfamiliar to most companies in Malaysia despite being around for more than a decade. This is not surprising considering the penetration rate of only 3.84% in Malaysia. The main aim of this paper is to examine the Malaysian firm‟s perceptions of TCI value and the TCI value drivers to help credit insurance companies uncover the motivational factors according to firm size and profit margin in order to improve the penetration rate in Malaysia. Furtherm...

  7. Predicting Malaysian palm oil price using Extreme Value Theory

    Chuangchid, K; Sriboonchitta, S; Rahman, S; Wiboonpongse, A

    2013-01-01

    This paper uses the extreme value theory (EVT) to predict extreme price events of Malaysian palm oil in the future, based on monthly futures price data for a 25 year period (mid-1986 to mid-2011). Model diagnostic has confirmed non-normal distribution of palm oil price data, thereby justifying the use of EVT. Two principal approaches to model extreme values – the Block Maxima (BM) and Peak-Over- Threshold (POT) models – were used. Both models revealed that the palm oil price will peak at ...

  8. Radiation processing program at the Malaysian Nuclear Agency

    Khairul Zaman

    2007-01-01

    Radiation processing technology has been proven to enhance industrial efficiency and productivity, improve product quality and competitiveness. For many years, variety of radiation crosslinkable materials based on synthetic polymers have been studied at the Malaysian Nuclear Agency either in the form of thermoplastic resins, polymer blends or composites. At present, effort is focused towards developing new materials based on natural polymers such as natural rubber and rubber based products, palm oil and palm oil based products and polysaccharide. In this respect, the most challenging issues are to develop new materials/products that have commercial value and to bring the products from laboratory to market. (author)

  9. Malaysian Journal of Medical Sciences Striving towards Visibility

    GHAZLI, Nur Farahin; ABDULLAH, Jafri Malin

    2013-01-01

    The Malaysian Journal of Medical Sciences has in its 25 years “Silver Jubilee” achieved another milestone of being visible to the biomedical community when it was accepted in PubMed. The journal aim to increase its readership so as to increase impact in the biomedical field amongst its Asian readers despite having a high rejection rate. This was done to maintain quality of the manuscripts published over the years. PubMed listing should enable more manuscripts to be cited as its the leading biomedical journal for the Asian community. PMID:24043990

  10. Dosimetry audits and intercomparisons in radiotherapy: A Malaysian profile

    Noor, Noramaliza M.; Nisbet, A.; Hussein, M.; Chu S, Sarene; Kadni, T.; Abdullah, N.; Bradley, D.A.

    2017-01-01

    Quality audits and intercomparisons are important in ensuring control of processes in any system of endeavour. Present interest is in control of dosimetry in teletherapy, there being a need to assess the extent to which there is consistent radiation dose delivery to the patient. In this study we review significant factors that impact upon radiotherapy dosimetry, focusing upon the example situation of radiotherapy delivery in Malaysia, examining existing literature in support of such efforts. A number of recommendations are made to provide for increased quality assurance and control. In addition to this study, the first level of intercomparison audit i.e. measuring beam output under reference conditions at eight selected Malaysian radiotherapy centres is checked; use being made of 9 µm core diameter Ge-doped silica fibres (Ge-9 µm). The results of Malaysian Secondary Standard Dosimetry Laboratory (SSDL) participation in the IAEA/WHO TLD postal dose audit services during the period between 2011 and 2015 will also been discussed. In conclusion, following review of the development of dosimetry audits and the conduct of one such exercise in Malaysia, it is apparent that regular periodic radiotherapy audits and intercomparison programmes should be strongly supported and implemented worldwide. The programmes to-date demonstrate these to be a good indicator of errors and of consistency between centres. A total of ei+ght beams have been checked in eight Malaysian radiotherapy centres. One out of the eight beams checked produced an unacceptable deviation; this was found to be due to unfamiliarity with the irradiation procedures. Prior to a repeat measurement, the mean ratio of measured to quoted dose was found to be 0.99 with standard deviation of 3%. Subsequent to the repeat measurement, the mean distribution was 1.00, and the standard deviation was 1.3%. - Highlights: • We review significant factors that impact upon radiotherapy dosimetry, • We carried out the

  11. Radiotracer laboratory for agricultural research at the Malaysian Nuclear Agency

    Nashriyah Mat; Misman Sumin; Maizatul Akmam Mhd Nasir

    2007-01-01

    Radiotracer Laboratory for agricultural research at the Malaysian Nuclear Agency was established since 1990. It accommodates three laboratories, three chemical temporary storage compartments plus one compartment for storage of pressurized gas. This facility is situated in ground floor of Block 44, Agrotechnology and Biosciences Division, Dengkil Complex. Currently it houses a liquid scintillation counter, sample oxidizer, gas liquid chromatography, high performance liquid chromatography and auxiliary equipments. A road map for this laboratory will be discussed in relation with present scenario i.e. R and D service, training and consultancy provided by this laboratory; and future requirements and direction. (Author)

  12. Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy

    Kay Andrea

    2009-10-01

    Full Text Available Abstract The mammalian target of rapamycin (mTOR is an intracellular serine/threonine protein kinase positioned at a central point in a variety of cellular signaling cascades. The established involvement of mTOR activity in the cellular processes that contribute to the development and progression of cancer has identified mTOR as a major link in tumorigenesis. Consequently, inhibitors of mTOR, including temsirolimus, everolimus, and ridaforolimus (formerly deforolimus have been developed and assessed for their safety and efficacy in patients with cancer. Temsirolimus is an intravenously administered agent approved by the US Food and Drug Administration (FDA and the European Medicines Agency (EMEA for the treatment of advanced renal cell carcinoma (RCC. Everolimus is an oral agent that has recently obtained US FDA and EMEA approval for the treatment of advanced RCC after failure of treatment with sunitinib or sorafenib. Ridaforolimus is not yet approved for any indication. The use of mTOR inhibitors, either alone or in combination with other anticancer agents, has the potential to provide anticancer activity in numerous tumor types. Cancer types in which these agents are under evaluation include neuroendocrine tumors, breast cancer, leukemia, lymphoma, hepatocellular carcinoma, gastric cancer, pancreatic cancer, sarcoma, endometrial cancer, and non-small-cell lung cancer. The results of ongoing clinical trials with mTOR inhibitors, as single agents and in combination regimens, will better define their activity in cancer.

  13. PI3K/Akt/mTOR Intracellular Pathway and Breast Cancer: Factors, Mechanism and Regulation.

    Sharma, Var Ruchi; Gupta, Girish Kumar; Sharma, A K; Batra, Navneet; Sharma, Daljit K; Joshi, Amit; Sharma, Anil K

    2017-01-01

    The most recurrent and considered second most frequent cause of cancer-related deaths worldwide in women is the breast cancer. The key to diagnosis is early prediction and a curable stage but still treatment remains a great clinical challenge. Origin of the Problem: A number of studies have been carried out for the treatment of breast cancer which includes the targeted therapies and increased survival rates in women. Essential PI3K/mTOR signaling pathway activation has been observed in most breast cancers. The cell growth and tumor development in such cases involve phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) complex intracellular pathway. Through preclinical and clinical trials, it has been observed that there are a number of other inhibitors of PI3K/Akt/mTOR pathway, which either alone or in combination with cytotoxic agents can be used for endocrine therapies. Structure and regulation/deregulation of mTOR provides a greater insight into the action mechanism. Also, through this review, one could easily scan first and second generation inhibitors for PI3K/Akt/mTOR pathway besides targeted therapies for breast cancer and the precise role of mTOR. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  14. The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii

    María Esther Pérez-Pérez

    2017-07-01

    Full Text Available Cell growth is tightly coupled to nutrient availability. The target of rapamycin (TOR kinase transmits nutritional and environmental cues to the cellular growth machinery. TOR functions in two distinct multiprotein complexes, termed TOR complex 1 (TORC1 and TOR complex 2 (TORC2. While the structure and functions of TORC1 are highly conserved in all eukaryotes, including algae and plants, TORC2 core proteins seem to be missing in photosynthetic organisms. TORC1 controls cell growth by promoting anabolic processes, including protein synthesis and ribosome biogenesis, and inhibiting catabolic processes such as autophagy. Recent studies identified rapamycin-sensitive TORC1 signaling regulating cell growth, autophagy, lipid metabolism, and central metabolic pathways in the model unicellular green alga Chlamydomonas reinhardtii. The central role that microalgae play in global biomass production, together with the high biotechnological potential of these organisms in biofuel production, has drawn attention to the study of proteins that regulate cell growth such as the TOR kinase. In this review we discuss the recent progress on TOR signaling in algae.

  15. Discovery and Development of ATP-Competitive mTOR Inhibitors Using Computational Approaches.

    Luo, Yao; Wang, Ling

    2017-11-16

    The mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism, and angiogenesis. This protein is an attractive target for new anticancer drug development. Significant progress has been made in hit discovery, lead optimization, drug candidate development and determination of the three-dimensional (3D) structure of mTOR. Computational methods have been applied to accelerate the discovery and development of mTOR inhibitors helping to model the structure of mTOR, screen compound databases, uncover structure-activity relationship (SAR) and optimize the hits, mine the privileged fragments and design focused libraries. Besides, computational approaches were also applied to study protein-ligand interactions mechanisms and in natural product-driven drug discovery. Herein, we survey the most recent progress on the application of computational approaches to advance the discovery and development of compounds targeting mTOR. Future directions in the discovery of new mTOR inhibitors using computational methods are also discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  16. The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii.

    Pérez-Pérez, María Esther; Couso, Inmaculada; Crespo, José L

    2017-07-12

    Cell growth is tightly coupled to nutrient availability. The target of rapamycin (TOR) kinase transmits nutritional and environmental cues to the cellular growth machinery. TOR functions in two distinct multiprotein complexes, termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2). While the structure and functions of TORC1 are highly conserved in all eukaryotes, including algae and plants, TORC2 core proteins seem to be missing in photosynthetic organisms. TORC1 controls cell growth by promoting anabolic processes, including protein synthesis and ribosome biogenesis, and inhibiting catabolic processes such as autophagy. Recent studies identified rapamycin-sensitive TORC1 signaling regulating cell growth, autophagy, lipid metabolism, and central metabolic pathways in the model unicellular green alga Chlamydomonas reinhardtii . The central role that microalgae play in global biomass production, together with the high biotechnological potential of these organisms in biofuel production, has drawn attention to the study of proteins that regulate cell growth such as the TOR kinase. In this review we discuss the recent progress on TOR signaling in algae.

  17. The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas

    Pinelopi Argyriou

    2012-01-01

    Full Text Available Despite the fact that the majority of lymphomas initially respond to treatment, many patients relapse and die from disease that is refractory to current regimens. The need for new treatment strategies in lymphomas has led to the investigation and evaluation of novel agents that target cellular pathways. The mammalian target of rapamycin (mTOR is a representative pathway that may be implicated in lymphomagenesis. Rapamycin and especially its derivatives (temsirolimus, everolimus, and deforolimus represent the first described mTOR inhibitors. These agents have shown promising results in the treatment of lymphoid malignancies. On the other hand, new ATP-competitive mTOR inhibitors that provoke a broader inhibition of mTOR activity are in early stages of clinical development. The purpose of this paper is to summarize the existing knowledge about mTOR inhibitors and their use in the treatment of B-cell lymphomas. Relevant issues regarding mTOR biology in general as well as in B-cell lymphoid neoplasms are also discussed in short.

  18. Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR.

    Erdogan, Cihan Suleyman; Hansen, Benni Winding; Vang, Ole

    2016-01-01

    Ageing is the organisms increased susceptibility to death, which is linked to accumulated damage in the cells and tissues. Ageing is a complex process regulated by crosstalk of various pathways in the cells. Ageing is highly regulated by the Target of Rapamycin (TOR) pathway activity. TOR is an evolutionary conserved key protein kinase in the TOR pathway that regulates growth, proliferation and cell metabolism in response to nutrients, growth factors and stress. Comparing the ageing process in invertebrate model organisms with relatively short lifespan with mammals provides valuable information about the molecular mechanisms underlying the ageing process faster than mammal systems. Inhibition of the TOR pathway activity via either genetic manipulation or rapamycin increases lifespan profoundly in most invertebrate model organisms. This contribution will review the recent findings in invertebrates concerning the TOR pathway and effects of TOR inhibition by rapamycin on lifespan. Besides some contradictory results, the majority points out that rapamycin induces longevity. This suggests that administration of rapamycin in invertebrates is a promising tool for pursuing the scientific puzzle of lifespan prolongation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Glucose-ABL1-TOR Signaling Modulates Cell Cycle Tuning to Control Terminal Appressorial Cell Differentiation.

    Marroquin-Guzman, Margarita; Sun, Guangchao; Wilson, Richard A

    2017-01-01

    The conserved target of rapamycin (TOR) pathway integrates growth and development with available nutrients, but how cellular glucose controls TOR function and signaling is poorly understood. Here, we provide functional evidence from the devastating rice blast fungus Magnaporthe oryzae that glucose can mediate TOR activity via the product of a novel carbon-responsive gene, ABL1, in order to tune cell cycle progression during infection-related development. Under nutrient-free conditions, wild type (WT) M. oryzae strains form terminal plant-infecting cells (appressoria) at the tips of germ tubes emerging from three-celled spores (conidia). WT appressorial development is accompanied by one round of mitosis followed by autophagic cell death of the conidium. In contrast, Δabl1 mutant strains undergo multiple rounds of accelerated mitosis in elongated germ tubes, produce few appressoria, and are abolished for autophagy. Treating WT spores with glucose or 2-deoxyglucose phenocopied Δabl1. Inactivating TOR in Δabl1 mutants or glucose-treated WT strains restored appressorium formation by promoting mitotic arrest at G1/G0 via an appressorium- and autophagy-inducing cell cycle delay at G2/M. Collectively, this work uncovers a novel glucose-ABL1-TOR signaling axis and shows it engages two metabolic checkpoints in order to modulate cell cycle tuning and mediate terminal appressorial cell differentiation. We thus provide new molecular insights into TOR regulation and cell development in response to glucose.

  20. Ribosomal protein S6 phosphorylation is controlled by TOR and modulated by PKA in Candida albicans.

    Chowdhury, Tahmeena; Köhler, Julia R

    2015-10-01

    TOR and PKA signaling pathways control eukaryotic cell growth and proliferation. TOR activity in model fungi, such as Saccharomyces cerevisiae, responds principally to nutrients, e.g., nitrogen and phosphate sources, which are incorporated into the growing cell mass; PKA signaling responds to the availability of the cells' major energy source, glucose. In the fungal commensal and pathogen, Candida albicans, little is known of how these pathways interact. Here, the signal from phosphorylated ribosomal protein S6 (P-S6) was defined as a surrogate marker for TOR-dependent anabolic activity in C. albicans. Nutritional, pharmacologic and genetic modulation of TOR activity elicited corresponding changes in P-S6 levels. The P-S6 signal corresponded to translational activity of a GFP reporter protein. Contributions of four PKA pathway components to anabolic activation were then examined. In high glucose concentrations, only Tpk2 was required to upregulate P-S6 to physiologic levels, whereas all four tested components were required to downregulate P-S6 in low glucose. TOR was epistatic to PKA components with respect to P-S6. In many host niches inhabited by C. albicans, glucose is scarce, with protein being available as a nitrogen source. We speculate that PKA may modulate TOR-dependent cell growth to a rate sustainable by available energy sources, when monomers of anabolic processes, such as amino acids, are abundant. © 2015 John Wiley & Sons Ltd.

  1. mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity.

    Jin, Zhe-Zhu; Wang, Wei; Fang, Di-Long; Jin, Yong-Jun

    2016-09-30

    We here tested the anti-colorectal cancer (CRC) activity by a first-in-class small molecule TRAIL inducer ONC201. The potential effect of mTOR on ONC201's actions was also examined. ONC201 induced moderate cytotoxicity against CRC cell lines (HT-29, HCT-116 and DLD-1) and primary human CRC cells. Significantly, AZD-8055, a mTOR kinase inhibitor, sensitized ONC201-induced cytotoxicity in CRC cells. Meanwhile, ONC201-induced TRAIL/death receptor-5 (DR-5) expression, caspase-8 activation and CRC cell apoptosis were also potentiated with AZD-8055 co-treatment. Reversely, TRAIL sequestering antibody RIK-2 or the caspase-8 specific inhibitor z-IETD-fmk attenuated AZD-8055 plus ONC201-induced CRC cell death. Further, mTOR kinase-dead mutation (Asp-2338-Ala) or shRNA knockdown significantly sensitized ONC201's activity in CRC cells, leading to profound cell death and apoptosis. On the other hand, expression of a constitutively-active S6K1 (T389E) attenuated ONC201-induced CRC cell apoptosis. For the mechanism study, we showed that ONC201 blocked Akt, but only slightly inhibited mTOR in CRC cells. Co-treatment with AZD-8055 also concurrently blocked mTOR activation. These results suggest that mTOR could be a primary resistance factor of ONC201 in CRC cells. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Comparison of thermoregulatory responses to heat between Malaysian and Japanese males during leg immersion

    Wijayanto, Titis; Wakabayashi, Hitoshi; Lee, Joo-Young; Hashiguchi, Nobuko; Saat, Mohamed; Tochihara, Yutaka

    2011-07-01

    The objective of this study was to investigate thermoregulatory responses to heat in tropical (Malaysian) and temperate (Japanese) natives, during 60 min of passive heating. Ten Japanese (mean ages: 20.8 ± 0.9 years) and ten Malaysian males (mean ages: 22.3 ± 1.6 years) with matched morphological characteristics and physical fitness participated in this study. Passive heating was induced through leg immersion in hot water (42°C) for 60 min under conditions of 28°C air temperature and 50% RH. Local sweat rate on the forehead and thigh were significantly lower in Malaysians during leg immersion, but no significant differences in total sweat rate were observed between Malaysians (86.3 ± 11.8 g m-2 h-1) and Japanese (83.2 ± 6.4 g m-2 h-1) after leg immersion. In addition, Malaysians displayed a smaller rise in rectal temperature (0.3 ± 0.1°C) than Japanese (0.7 ± 0.1°C) during leg immersion, with a greater increase in hand skin temperature. Skin blood flow was significantly lower on the forehead and forearm in Malaysians during leg immersion. No significant different in mean skin temperature during leg immersion was observed between the two groups. These findings indicated that regional differences in body sweating distribution might exist between Malaysians and Japanese during heat exposure, with more uniform distribution of local sweat rate over the whole body among tropical Malaysians. Altogether, Malaysians appear to display enhanced efficiency of thermal sweating and thermoregulatory responses in dissipating heat loss during heat loading. Thermoregulatory differences between tropical and temperate natives in this study can be interpreted as a result of heat adaptations to physiological function.

  3. A perspective of the Malaysian highway energy consumption and future power supply

    Saqr, Khalid M.; Musa, Md. Nor

    2011-01-01

    In this short communication, we discuss the energy consumption trends in the Malaysian road transport sector, with a special emphasis on the energy losses due to vehicle aerodynamic drag on highways. The recent trends of energy consumption in the Malaysian road transport sector are reviewed. It is evidently shown that the aerodynamic losses represented exceed 1.2 MTOE annually since 2002. A novel concept of vertical-axis wind turbine (VAWT) farms for harvesting aerodynamic energy losses on Malaysian highways is preliminarily proposed. The novel concept aims at providing a sustainable and green energy source for the lighting of the highway network in the country.

  4. Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control.

    Amélie Avet-Rochex

    2014-09-01

    Full Text Available Neuronal differentiation is exquisitely controlled both spatially and temporally during nervous system development. Defects in the spatiotemporal control of neurogenesis cause incorrect formation of neural networks and lead to neurological disorders such as epilepsy and autism. The mTOR kinase integrates signals from mitogens, nutrients and energy levels to regulate growth, autophagy and metabolism. We previously identified the insulin receptor (InR/mTOR pathway as a critical regulator of the timing of neuronal differentiation in the Drosophila melanogaster eye. Subsequently, this pathway has been shown to play a conserved role in regulating neurogenesis in vertebrates. However, the factors that mediate the neurogenic role of this pathway are completely unknown. To identify downstream effectors of the InR/mTOR pathway we screened transcriptional targets of mTOR for neuronal differentiation phenotypes in photoreceptor neurons. We identified the conserved gene unkempt (unk, which encodes a zinc finger/RING domain containing protein, as a negative regulator of the timing of photoreceptor differentiation. Loss of unk phenocopies InR/mTOR pathway activation and unk acts downstream of this pathway to regulate neurogenesis. In contrast to InR/mTOR signalling, unk does not regulate growth. unk therefore uncouples the role of the InR/mTOR pathway in neurogenesis from its role in growth control. We also identified the gene headcase (hdc as a second downstream regulator of the InR/mTOR pathway controlling the timing of neurogenesis. Unk forms a complex with Hdc, and Hdc expression is regulated by unk and InR/mTOR signalling. Co-overexpression of unk and hdc completely suppresses the precocious neuronal differentiation phenotype caused by loss of Tsc1. Thus, Unk and Hdc are the first neurogenic components of the InR/mTOR pathway to be identified. Finally, we show that Unkempt-like is expressed in the developing mouse retina and in neural stem

  5. Anti-gout Potential of Malaysian Medicinal Plants

    Fazleen I. Abu Bakar

    2018-03-01

    Full Text Available Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%; specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated.

  6. The Malaysian health care system: Ecology, plans, and reforms

    Andrea Sebastian

    2016-08-01

    Full Text Available Malaysia is on its way to achieving developed nation status in the next 4 years. Currently, Malaysia is on track for three Millennium Development Goals (MDG1, MDG4, and MDG7. The maternal mortality rate, infant mortality rate, and mortality rate of children younger than 5 years improved from 25.6% (2012 to 6.6% (2013, and 7.7% (2012 per 100,000 live births, respectively whereas immunization coverage for infants increased to an average of 90%. As of 2013 the ratio of physicians to patients improved to 1:633 while the ratio of health facilities to the population was 1:10,272. The current government administration has proposed a reform in the form of the 10th Malaysian Plan coining the term “One Care for One Malaysia” as the newly improved and reorganized health care plan, where efficiency, effectiveness, and equity are the main focus. This review illustrates Malaysia’s transition from pre-independence to the current state, and its health and socioeconomic achievement as a country. It aims to contribute knowledge through identifying the plans and reforms by the Malaysian government while highlighting the challenges faced as a nation.

  7. A change in strategy: Static emotion recognition in Malaysian Chinese

    Chrystalle B.Y. Tan

    2015-12-01

    Full Text Available Studies have shown that while East Asians focused on the center of the face to recognize identities, participants adapted their strategy by focusing more on the eyes to identify emotions, suggesting that the eyes may contain salient information pertaining to emotional state in Eastern cultures. However, Western Caucasians employ the same strategy by moving between the eyes and mouth to identify both identities and emotions. Malaysian Chinese have been shown to focus on the eyes and nose more than the mouth during face recognition task, which represents an intermediate between Eastern and Western looking strategies. The current study examined whether Malaysian Chinese continue to employ an intermediate strategy or shift towards an Eastern or Western pattern (by fixating more on the eyes or mouth respectively during an emotion recognition task. Participants focused more on the eyes, followed by the nose then mouth. Directing attention towards the eye region resulted in better recognition of certain own- than other-race emotions. Although the fixation patterns appear similar for both tasks, further analyses showed that fixations on the eyes were reduced whereas fixations on the nose and mouth were increased during emotion recognition, indicating that participants adapt looking strategies based on their aims.

  8. Anti-gout Potential of Malaysian Medicinal Plants.

    Abu Bakar, Fazleen I; Abu Bakar, Mohd F; Rahmat, Asmah; Abdullah, Norazlin; Sabran, Siti F; Endrini, Susi

    2018-01-01

    Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: "gout," "medicinal plants," "Malaysia," "epidemiology," " in vitro," and " in vivo ." In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris , and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated.

  9. Malaysian aviation technologist promotion to managerial role: an empirical overview

    Liew, C. L.; Abu Talib, A. R.; Jacobs, R. L.

    2016-10-01

    The Malaysian aviation industry has continued to march forward. With a turnover of RM23.7 billion in 2013, it is expected to grow higher especially after the Malaysian national aerospace blueprint was launched in 2015. The aviation related organizations currently have a workforce of approximately 13500. These organizations need to be managed by competent managers who have a strong background of technologist. Aviation technologist is one of the key components in the aviation maintenance industry as they are the future managers charged with the responsibility to ensure continuation of the organization's objectives and culture. The technologist role and manager's role are somehow different. The promotion of technologist to managerial roles is quite common but whether the technologist is able to take up managerial role effectively is yet to be fully understood. It is quite common that there was insufficient training for the technologist before being promoted to take up management roles. The purpose of this paper is to give an overview of the role of technologists and managers in professional services industries such as MRO and to understand that there is a need within the industry to re-look into the perspective of a proper training to prepare them to take up management roles effectively.

  10. Folate content and availability in Malaysian cooked foods.

    Chew, S C; Khor, G L; Loh, S P

    2012-12-01

    Data on folate availability of Malaysian cooked foods would be useful for estimation of dietary folate intake; however such information is scarce. A total of 53 samples of frequently consumed foods in Malaysia were selected from the Nutrient Composition of Malaysian Foods. Folate content was determined using HPLC method hyphenated with a stainless steel C18 column and ultraviolet detector (lambda = 280 nm). The index of folate availability was defined as the proportion of folate identified as monoglutamyl derivatives from the total folate content. Total folate content of different food samples varied from 30-95 microg/100g fresh weight. Among rice-based dishes, the highest and the lowest total folate was in coconut milk rice (nasi lemak) and ghee rice (nasi minyak), respectively. In noodle dishes, fried rice noodle (kuey teow goreng) and curry noodle (mee kari) had the highest folate contents. The highest index of folate availability was in a flat rice noodle dish (kuey teow bandung) (12.13%), while the lowest was in a festival cake (kuih bakul) (0.13%). Folate content was found to be negatively related to its availability. This study determined folate content and folate availability in commonly consumed cooked foods in Malaysia. The uptake of folate from foods with high folate content may not be necessarily high as folate absorption also depends on the capacity of intestinal deconjugation and the presence of high fibre in the foods.

  11. Ownership patterns and control of top 100 Malaysian listed companies

    Che-Ahmad Ayoib B

    2017-01-01

    Full Text Available The incentive of this study stems from the significance of protecting minority shareholders’ rights. It analyses the most dominant ownership structure practices within listed firms in Bursa Malaysia (BM, in which controlling shareholders (CSs hold control on many firms despite relatively small portion of investment. Malaysian firms are characterised by high levels of concentrated ownership with families owning more than 70% of the listed firms in BM [9]. This study finds that the separation between cash flow rights (real investment and control rights (voting rights for Top 100 Malaysian listed firms is accomplished through pyramidal ownership and golden share arrangements. Hence, the divergence between cash flow rights (CFRs and voting rights (VRs exacerbates Type II Agency problem. This study calls for future studies in the area of accounting and finance to introduce and operationalise new measurement of Type II Agency Cost in order to better understand the agency conflicts within this unique market. It also better explains the state of the minority shareholders in the BM.

  12. Accountability of Radioactive Materials in Malaysian Nuclear Agency

    Noor Fadilla Ismail; Wan Saffiey Wan Abdullah; Khairuddin Mohamad Kontol; Azimawati Ahmad; Suzilawati Muhd Sarowi; Mohd Fazlie Abdul Rashid

    2016-01-01

    Radioactive materials possessed in Malaysian Nuclear Agency have many beneficial applications for research and development, calibration, tracer and irradiation. There are two types of radioactive materials which consist of sealed sourced and unsealed sourced shall be accounted for and secured at all the times by following the security aspect. The Health Physics Group in the Department of Radiation Safety and Health Division is responsible to manage the issues related to any accountability for all radioactive material purchased or received under the radioactive material protocol. The accountability of radioactive materials in Malaysian Nuclear Agency is very important to ensure the security and control the radioactive materials to not to be lost or fall into the hands of people who do not have permission to possess or use it. The accountability of radioactive materials considered as a mandatory to maintaining accountability by complying the requirements of the Atomic Energy Licensing Act 1984 (Act 304) and regulations made thereunder and the conditions of license LPTA / A / 724. In this report describes the important element of accountability of radioactive materials in order to enhances security standard by allowing tracking of the locations of sources and to reduce the risk of radioactive materials falling into the wrong hands. (author)

  13. Self-perceived mental well-being amongst Malaysian dentists.

    Ab-Murat, Norintan; Mason, Lydia; Kadir, Rahimah Abdul; Yusoff, Noriah

    2018-06-01

    To assess Malaysian dentists' perceptions of their mental well-being. A self-administered questionnaire was developed based on a conceptual framework of mental health and well-being model. Two aspects were assessed, namely the physiological (two domains) and the psychological (six domains). Participants were asked to rate their experiences of the aforementioned aspects using a 5-point Likert scale ranging from all the time to never. The response rate was 81%. Most of the dentists (61.7%) perceived having positive mental well-being. Under the physiological aspect, most respondents reported that they were 'generally happy' (93.3%), but about 30% stated they were 'stressed physically and emotionally'. Of the six domains under the psychological aspect, positive well-being was observed in the 'sense of coherence' and 'behavioural stress' domains. Participants who were above 40 years old, married and had children reported having a more positive mental well-being when compared with their counterparts. Overall, most Malaysian dentists perceived having a positive mental well-being. It is crucial, however, to closely monitor and initiate early interventions for those with negative symptoms to ensure the safe practice of dentistry.

  14. The Readability of Malaysian English Children Books: A Multilevel Analysis

    Adlina Ismail

    2016-11-01

    Full Text Available These days, there are more English books for children published by local publishers in Malaysia. It is a positive development because the books will be more accessible to the children. However, the books have never been studied and evaluated in depth yet. One important factor in assessing reading materials is readability. Readability determines whether a text is easy or difficult to understand and a balanced mix of both can promote learning and language development. Various researchers mentioned a multilevel framework of discourse that any language assessment on a text should take into account. The levels that were proposed were word, syntax, textbase, situation model and genre and rhetorical structures. Traditional readability measures such as Flesh Reading Ease Formula, Gunning Readability Index, Fog Count, and Fry Grade Level are not able to address the multilevel because they are based on shallow variables. In contrast, Coh-metrix TERA provided five indices that are correlated to grade level and aligned to the multilevel framework. This study analyzed ten Malaysian English chapter books for children using this Coh-metrix TERA. The result revealed that the Malaysian English children books were easy in shallow level but there was a possible difficulty in textbase and situation model level because of the lack of cohesion. In conclusion, more attention should be given on deeper level of text rather than just word and syntax level.

  15. Cross-linguistic transfer of phonological skills: a Malaysian perspective.

    Gomez, Caroline; Reason, Rea

    2002-01-01

    This study examined the phonological and reading performance in English of Malaysian children whose home language was Bahasa Malaysia (BM). A sample of 69 Malaysian Standard Two pupils (aged 7-8 years) was selected for the study. Since commencing school at the age of 6 years, the children had been learning to read in BM and had subsequently also been learning to read in English for some 12 months. The study was part of a larger scale research programme that fully recognized the limitations of tests that had not been developed and standardized in Malaysia. Nevertheless, as a first step to developing such tests, a comparison with existing norms for the Phonological Assessment Battery (PhAB) and the Wechsler Objective Reading Dimension (WORD) was undertaken in relation to information about the children's L1 and L2 language competencies. Results showed that the children's performance on PhAB was at least comparable to the UK norms while, not surprisingly, they fared less well on WORD. The results are discussed in terms of L1 and L2 transfer, whereby the transparency of written BM and the structured way in which reading is taught in BM facilitates performance on phonological tasks in English. This has implications for identifying children with phonologically based reading difficulties.

  16. Exploring Familial Themes in Malaysian Students’ Eating Behaviors

    Car Mun Kok

    2013-06-01

    Full Text Available Food-related attitudes and habits are integral to overall well-being, especially among international college students who often practice poor eating habits and experience high levels of stress from factors like school and sociocultural adjustment. Utilizing in-depth interviews, this study explored how family experiences impact food-related habits, attitudes, and beliefs of Malaysian college students in the U.S. Findings indicate that early experiences with family substantially impact current habits that persist even after coming to the U.S. and that dietary choices and habits are heavily embedded in cultural background and family history. Family influenced current habits through multiple means, including modeling, direct teaching, and indirectly through various family activities. Even though there were some persistent and lasting eating habits and behaviors, students also experienced some dietary changes and conflicting dietary practices after coming to the U.S. These findings are important for universities to consider so that appropriate steps can be taken to ensure the health and well-being of Malaysian and other international students in the U.S.

  17. Perceived sources of stress among Malaysian dental students.

    Babar, Muneer G; Hasan, Syed S; Ooi, Yong J; Ahmed, Syed I; Wong, Pei S; Ahmad, Siti F; Mnm-Rosdy, Nik M; Malik, Normaliza A

    2015-05-02

    The study objectives were to identify the stress levels and to explore the impact of students' year of study and gender on the perceived sources of stress among Malaysian dental students. This was a cross-sectional study involving dental students from year one to year five from private and public universities in Malaysia. The study was formally approved by the Research and Ethics Committee, International Medical University Malaysia. Dental Environment Stress (DES) questionnaire was used for data collection and the gathered data were analyzed using SPSS® version 18. The Kruskal-Wallis and the Mann-Whitney U tests were used to compare stress items across various academic years and universities. A total of five hundred and twenty nine (529) students participated in this study. Fear of failing the course at the end of year exams (mean stress level=5.57); concerns regarding completion of clinical work (mean=5.30); and examination results and grades (mean=5.27) were found as top stressors among dental students. Female students had higher stress scores than males with respect to personal issues, academic performance, educational environment and learning of clinical skills. Students from public universities had higher stress scores than their counterparts from private universities. The Malaysian dental students reported higher levels of stress. Present study identified stressors affecting dental students' academic life, and highlights the importance of stress management programs and other measures to minimize the impact of stress on both academic and personal lives of the students.

  18. Applications of building information model (BIM) in Malaysian construction industry

    Tahir, M. M.; Haron, N. A.; Alias, A. H.; Al-Jumaa, A. T.; Muhammad, I. B.; Harun, A. N.

    2017-12-01

    Since the introduction of BIM in Malaysia in 2009, the technology adoption rate is slow when compared to other countries of the world. Most of the construction companies in Malaysia have an insight on the BIM concept but are yet to implement it in the management of their construction projects. By the year 2020, the Malaysian government will make BIM mandatory, this makes it important to carry out research on the possible applications of the technology. A qualitative method of enquiry was used for this study in Klang Valley using semistructured interview. The responses received were analysed using Principal component analysis (PCA). The result of the analysis showed that “quantity take-off and estimation”, “clash detection and coordination”, “integration and collaboration of stakeholders”, and “design and visualisation” as the main applications of BIM in Malaysia presently. The implication of this findings is that the Malaysian construction industry productivity is likely to increase to meet the demand of the population through the implementations of BIM. More also, BIM technology is regarded as the future of construction industry, which makes it very important for the industry.

  19. Take-over again: Investigating multimodal and directional TORs to get the driver back into the loop.

    Petermeijer, Sebastiaan; Bazilinskyy, Pavlo; Bengler, Klaus; de Winter, Joost

    2017-07-01

    When a highly automated car reaches its operational limits, it needs to provide a take-over request (TOR) in order for the driver to resume control. The aim of this simulator-based study was to investigate the effects of TOR modality and left/right directionality on drivers' steering behaviour when facing a head-on collision without having received specific instructions regarding the directional nature of the TORs. Twenty-four participants drove three sessions in a highly automated car, each session with a different TOR modality (auditory, vibrotactile, and auditory-vibrotactile). Six TORs were provided per session, warning the participants about a stationary vehicle that had to be avoided by changing lane left or right. Two TORs were issued from the left, two from the right, and two from both the left and the right (i.e., nondirectional). The auditory stimuli were presented via speakers in the simulator (left, right, or both), and the vibrotactile stimuli via a tactile seat (with tactors activated at the left side, right side, or both). The results showed that the multimodal TORs yielded statistically significantly faster steer-touch times than the unimodal vibrotactile TOR, while no statistically significant differences were observed for brake times and lane change times. The unimodal auditory TOR yielded relatively low self-reported usefulness and satisfaction ratings. Almost all drivers overtook the stationary vehicle on the left regardless of the directionality of the TOR, and a post-experiment questionnaire revealed that most participants had not realized that some of the TORs were directional. We conclude that between the three TOR modalities tested, the multimodal approach is preferred. Moreover, our results show that directional auditory and vibrotactile stimuli do not evoke a directional response in uninstructed drivers. More salient and semantically congruent cues, as well as explicit instructions, may be needed to guide a driver into a specific

  20. GFR meets mTOR: value of different methods to measure and estimate GFR & (side) effects of mTOR inhibition in renal transplantation

    Baas, M.C.

    2011-01-01

    The subject of this thesis is twofold: where GFR and mTOR meet. Precise measurement of kidney function is difficult and cumbersome and many, simpler alternatives have been developed to determine GFR. Determination of GFR remains an approximation since the GFR itself is not a static phenomenon. This

  1. The nutrient transceptor/PKA pathway functions independently of TOR and responds to leucine and Gcn2 in a TOR-independent manner.

    Conrad, Michaela; Kankipati, Harish Nag; Kimpe, Marlies; Van Zeebroeck, Griet; Zhang, Zhiqiang; Thevelein, Johan M

    2017-08-01

    Two nutrient-controlled signalling pathways, the PKA and TOR pathway, play a major role in nutrient regulation of growth as well as growth-correlated properties in yeast. The relationship between the two pathways is not well understood. We have used Gap1 and Pho84 transceptor-mediated activation of trehalase and phosphorylation of fragmented Sch9 as a read-out for rapid nutrient activation of PKA or TORC1, respectively. We have identified conditions in which L-citrulline-induced activation of Sch9 phosphorylation is compromised, but not activation of trehalase: addition of the TORC1 inhibitor, rapamycin and low levels of L-citrulline. The same disconnection was observed for phosphate activation in phosphate-starved cells. The leu2 auxotrophic mutation reduces amino acid activation of trehalase, which is counteracted by deletion of GCN2. Both effects were also independent of TORC1. Our results show that rapid activation of the TOR pathway by amino acids is not involved in rapid activation of the PKA pathway and that effects of Gcn2 inactivation as well as leu2 auxotrophy all act independently of the TOR pathway. Hence, rapid nutrient signalling to PKA and TOR in cells arrested by nutrient starvation acts through parallel pathways. © FEMS 2017.

  2. Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR

    Kenneth Maiese

    2016-01-01

    Full Text Available Throughout the globe, diabetes mellitus (DM is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder. DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy. The mechanistic target of rapamycin (mTOR is a promising agent for the development of novel regenerative strategies for the treatment of DM. mTOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis, insulin resistance, insulin secretion, stem cell proliferation and differentiation, pancreatic β-cell function, and programmed cell death with apoptosis and autophagy. mTOR is central element for the protein complexes mTOR Complex 1 (mTORC1 and mTOR Complex 2 (mTORC2 and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase (PI 3-K, protein kinase B (Akt, AMP activated protein kinase (AMPK, silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae (SIRT1, Wnt1 inducible signaling pathway protein 1 (WISP1, and growth factors. As a result, mTOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease. Future studies directed to elucidate the delicate balance mTOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.

  3. Correlation between telomerase and mTOR pathway in cancer stem cells.

    Dogan, Fatma; Biray Avci, Cigir

    2018-01-30

    Cancer stem cells (CSCs), which are defined as a subset of tumor cells, are able to self-renew, proliferate, differentiate similar to normal stem cells. Therefore, targeting CSCs has been considered as a new approach in cancer therapy. The mammalian target of rapamycin (mTOR) is a receptor tyrosine kinase which plays an important role in regulating cell proliferation, differentiation, cell growth, self-renewal in CSCs. On the other hand, hTERT overactivation provides replicative feature and immortality to CSCs, so the stemness and replicative properties of CSCs depend on telomerase activity. Therefore hTERT/telomerase activity may become a universal biomarker for anticancer therapy and it is an attractive therapeutic target for CSCs. It is known that mTOR regulates telomerase activity at the translational and post-translational level. Researchers show that mTOR inhibitor rapamycin reduces telomerase activity without changing hTERT mRNA activity. Correlation between mTOR and hTERT is important for survival and immortality of cancer cells. In addition, the PI3K/AKT/mTOR signaling pathway and hTERT up-regulation are related with cancer stemness features and drug resistance. mTOR inhibitor and TERT inhibitor combination may construct a novel strategy in cancer stem cells and it can make a double effect on telomerase enzyme. Consequently, inhibition of PI3K/AKT/mTOR signaling pathway components and hTERT activation may prohibit CSC self-renewal and surpass CSC-mediated resistance in order to develop new cancer therapeutics. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Cortisol inhibits mTOR signaling in avascular necrosis of the femoral head.

    Liao, Yun; Su, Rui; Zhang, Ping; Yuan, Bo; Li, Ling

    2017-10-18

    ANFH is a major health problem, to which long lasting and definitive treatments are lacking. The aim of this study is to study RNA alterations attributed to cortisol-induced ANFH. Rat models were stratified into three groups: in vitro group (n = 20) for molecular biological assays, control group (n = 3), and ANFH group induced using lipopolysaccharide and dexamethasone (n = 3). Bone marrow-derived endothelial progenitor cells (BM-EPCs) were extracted from the rats. An RNA expression array was performed on BM-EPCs, and enriched genes were subject to pathway analysis. In vitro studies following findings of array results were also performed using the isolated BM-EPCs. Significant alterations in mammalian target of rapamycin (mTOR) and HIF signaling pathways were identified in BM-EPCs of ANFH. By applying cortisol and dexamethasone to BM-EPCs, significant changes in mTOR and HIF elements were identified. The alteration of HIF pathways appeared to be downstream of mTOR signaling. Glucocorticoid receptor (GR) expression was related to glucocorticoid-dependent mRNA expression of mTOR/HIF genes. mTOR-dependent angiogenesis but not anabolism was the target of GR in ANFH. Inhibition of mTOR signaling also induced apoptosis of BM-EPCs via CHOP-dependent DR5 induction in response to GR stimulation. Decreased mTOR signaling in response to GR stimulation leading to downregulated HIF pathway as well as increased apoptosis could be the pathophysiology.

  5. Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice.

    Susan M Lang

    Full Text Available The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/- mice, would exaggerate the changes in protein synthesis and degradation observed during hindlimb immobilization as well as impair normal muscle regrowth during the recovery period. Atrophy was produced by unilateral hindlimb immobilization and data compared to the contralateral gastrocnemius. In wild-type (WT mice, the gradual loss of muscle mass plateaued by day 7. This response was associated with a reduction in basal protein synthesis and development of leucine resistance. Proteasome activity was consistently elevated, but atrogin-1 and MuRF1 mRNAs were only transiently increased returning to basal values by day 7. When assessed 7 days after immobilization, the decreased muscle mass and protein synthesis and increased proteasome activity did not differ between WT and mTOR(+/- mice. Moreover, the muscle inflammatory cytokine response did not differ between groups. After 10 days of recovery, WT mice showed no decrement in muscle mass, and this accretion resulted from a sustained increase in protein synthesis and a normalization of proteasome activity. In contrast, mTOR(+/- mice failed to fully replete muscle mass at this time, a defect caused by the lack of a compensatory increase in protein synthesis. The delayed muscle regrowth of the previously immobilized muscle in the mTOR(+/- mice was associated with a decreased raptor•4EBP1 and increased raptor•Deptor binding. Slowed regrowth was also associated with a sustained inflammatory response (e.g., increased TNFα and CD45 mRNA during the recovery period and a failure of IGF-I to increase as in WT mice. These data suggest mTOR is relatively more important in regulating the accretion of muscle mass during recovery than the loss of muscle during the atrophy phase, and that protein synthesis is more sensitive than degradation to the reduction in mTOR during muscle regrowth.

  6. Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice.

    Lang, Susan M; Kazi, Abid A; Hong-Brown, Ly; Lang, Charles H

    2012-01-01

    The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/-) mice, would exaggerate the changes in protein synthesis and degradation observed during hindlimb immobilization as well as impair normal muscle regrowth during the recovery period. Atrophy was produced by unilateral hindlimb immobilization and data compared to the contralateral gastrocnemius. In wild-type (WT) mice, the gradual loss of muscle mass plateaued by day 7. This response was associated with a reduction in basal protein synthesis and development of leucine resistance. Proteasome activity was consistently elevated, but atrogin-1 and MuRF1 mRNAs were only transiently increased returning to basal values by day 7. When assessed 7 days after immobilization, the decreased muscle mass and protein synthesis and increased proteasome activity did not differ between WT and mTOR(+/-) mice. Moreover, the muscle inflammatory cytokine response did not differ between groups. After 10 days of recovery, WT mice showed no decrement in muscle mass, and this accretion resulted from a sustained increase in protein synthesis and a normalization of proteasome activity. In contrast, mTOR(+/-) mice failed to fully replete muscle mass at this time, a defect caused by the lack of a compensatory increase in protein synthesis. The delayed muscle regrowth of the previously immobilized muscle in the mTOR(+/-) mice was associated with a decreased raptor•4EBP1 and increased raptor•Deptor binding. Slowed regrowth was also associated with a sustained inflammatory response (e.g., increased TNFα and CD45 mRNA) during the recovery period and a failure of IGF-I to increase as in WT mice. These data suggest mTOR is relatively more important in regulating the accretion of muscle mass during recovery than the loss of muscle during the atrophy phase, and that protein synthesis is more sensitive than degradation to the reduction in mTOR during muscle regrowth.

  7. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of posttraumatic epilepsy

    Berdichevsky, Yevgeny; Dryer, Alexandra M.; Saponjian, Yero; Mahoney, Mark M.; Pimentel, Corrin A.; Lucini, Corrina A.; Usenovic, Marija; Staley, Kevin J.

    2013-01-01

    mTOR is activated in epilepsy, but the mechanisms of mTOR activation in post-traumatic epileptogenesis are unknown. It is also not clear whether mTOR inhibition has an antiepileptogenic, or merely anti-convulsive effect. The rat hippocampal organotypic culture model of post-traumatic epilepsy was used to study the effects of long term (four weeks) inhibition of signaling pathways that interact with mTOR. Ictal activity was quantified by measurement of lactate production and electrical recordi...

  8. Problem-Solving Skills and Suicidal Ideation Among Malaysian College Students: the Mediating Role of Hopelessness.

    Abdollahi, Abbas; Talib, Mansor Abu; Yaacob, Siti Nor; Ismail, Zanariah

    2016-04-01

    Recent evidence suggests that suicidal ideation has increased among Malaysian college students over the past two decades; therefore, it is essential to increase our knowledge concerning the etiology of suicidal ideation among Malaysian college students. This study was conducted to examine the relationships between problem-solving skills, hopelessness, and suicidal ideation among Malaysian college students. The participants included 500 undergraduate students from two Malaysian public universities who completed the self-report questionnaires. Structural equation modeling estimated that college students with poor problem-solving confidence, external personal control of emotion, and avoiding style were more likely to report suicidal ideation. Hopelessness partially mediated the relationship between problem-solving skills and suicidal ideation. These findings reinforce the importance of poor problem-solving skills and hopelessness as risk factors for suicidal ideation among college students.

  9. An Analysis of Malaysian Political Communication and Its Role in Electoral Process

    Saabar Suhaimee Saahar

    2017-01-01

    Full Text Available This paper attempts to discuss political communication in Malaysia especially after the 12th General Elections (GE12. The purpose of this study is to analyse the political efficacy or sense making process which involve analysing the techniques and creative execution that had been used by political parties and its effects on Malaysian voters. The results of GE 12 had fashioned a political tsunami that influenced many important aspects in the Malaysian political landscape, be it national and economic policies, social unity or campaign strategies. Therefore, the main focus of this paper is to discuss the elements and importance of political communication research in Malaysian political communication campaign by focusing on the aspects of creative execution, political information efficacy and sense making process and its impact on the choice of communication tools amongst Malaysian voters.

  10. Efficiency and Competition in the Malaysian Banking Market: Foreign versus Domestic Banks

    Rossazana Ab-Rahim

    2017-08-01

    Full Text Available The aim of this paper is to investigate efficiency performance of Malaysian banking market using data envelopment analysis approach in the context of the increasing presence of foreign banks. Specifically, two measures of efficiency are constructed, cost and profit efficiency by utilizing bank-level data of Malaysian commercial banks, over the period 2003 to 2014. The results obtained show the domestic banks are more efficient than the foreign banks counterparts for both measures of efficiency. Next, the Lerner Index approach is employed to measure competition and finally, Granger causality tests are undertaken to answer the question, does competition foster efficiency? The results of causality tests support a positive effect of competition on cost and profit efficiency of Malaysian banks. With regard to the financial liberalization, the findings imply that higher competitive pressure may be offset the market power of individual banks; however, eventually it will results in efficiency gains of Malaysian banks.

  11. A quantitative methodology to test ecological modernization theory in the Malaysian context

    Er Ah Choy,

    2007-01-01

    The rapid economic development accompanied by increasing manufacturing output in Malaysia for the past two decades is not balanced with sufficient environmental management. Although pollution control measures have been formulated and implemented by the Malaysian government, the improvements and

  12. Proceedings of the Malaysian Science and Technology Congress `94: Vol. II - new products and processes

    NONE

    1994-12-31

    New processes and products in the field of the Malaysian technology research were presented at the Science and Technology congress `94. Composite materials, semiconductors fabrication, optical fibers, zeolite properties etc. were discussed in 35 contributions.

  13. Proceedings of the Malaysian Science and Technology Congress '94: Vol. II - new products and processes

    1994-01-01

    New processes and products in the field of the Malaysian technology research were presented at the Science and Technology congress '94. Composite materials, semiconductors fabrication, optical fibers, zeolite properties etc. were discussed in 35 contributions

  14. VALIDITY OF THE BRUNEL MOOD SCALE FOR USE WITH MALAYSIAN ATHLETES

    Mohamad Faizal Lan

    2012-03-01

    Full Text Available The aim of the present study was to investigate the factorial validity of the Brunel Mood Scale for use with Malaysian athletes. Athletes (N = 1485 athletes competing at the Malaysian Games completed the Brunel of Mood Scale (BRUMS. Confirmatory Factor Analysis (CFA results indicated a Confirmatory Fit Index (CFI of .90 and Root Mean Squared Error of Approximation (RMSEA was 0.05. The CFI was below the 0.95 criterion for acceptability and the RMSEA value was within the limits for acceptability suggested by Hu and Bentler, 1999. We suggest that results provide some support for validity of the BRUMS for use with Malaysian athletes. Given the large sample size used in the present study, descriptive statistics could be used as normative data for Malaysian athletes

  15. Joint inhibition of TOR and JNK pathways interacts to extend the lifespan of Brachionus manjavacas (Rotifera).

    Snell, Terry W; Johnston, Rachel K; Rabeneck, Brett; Zipperer, Cody; Teat, Stephanie

    2014-04-01

    The TOR kinase pathway is central in modulating aging in a variety of animal models. The target of rapamycin (TOR) integrates a complex network of signals from growth conditions, nutrient availability, energy status, and physiological stresses and matches an organism's growth rate to the resource environment. Important remaining problems are the identification of the pathways that interact with TOR and their characterization as additive or synergistic. One of the most versatile stress sensors in metazoans is the Jun-N-terminal kinase (JNK) signaling pathway. JNK is an evolutionarily conserved stress-activated protein kinase that is induced by a range of stressors, including UV irradiation, reactive oxygen species, DNA damage, heat, and bacterial antigens. JNK is thought to interact with the TOR pathway, but its effects on TOR are poorly understood. We used the rotifer Brachionus manjavacas as a model animal to probe the regulation of TOR and JNK pathways and explore their interaction. The effect of various chemical inhibitors was examined in life table and stressor challenge experiments. A survey of 12 inhibitors revealed two, rapamycin and JNK inhibitor, that significantly extended lifespan of B. manjavacas. At 1 μM concentration, exposure to rapamycin or JNK inhibitor extended mean rotifer lifespan by 35% and maximum lifespan by 37%. Exposure to both rapamycin and JNK inhibitor simultaneously extended mean rotifer lifespan by 65% more than either alone. Exposure to a combination of rapamycin and JNK inhibitors conveyed greater protection to starvation, UV and osmotic stress than either inhibitor alone. RNAi knockdown of TOR and JNK gene expression was investigated for its ability to extend rotifer lifespan. RNAi knockdown of the TOR gene resulted in 29% extension of the mean lifespan compared to control and knockdown of the JNK gene resulted in 51% mean lifespan extension. In addition to the lifespan, we quantified mitochondria activity using the fluorescent

  16. Inferring the effective TOR-dependent network: a computational study in yeast.

    Mohammadi, Shahin; Subramaniam, Shankar; Grama, Ananth

    2013-08-30

    Calorie restriction (CR) is one of the most conserved non-genetic interventions that extends healthspan in evolutionarily distant species, ranging from yeast to mammals. The target of rapamycin (TOR) has been shown to play a key role in mediating healthspan extension in response to CR by integrating different signals that monitor nutrient-availability and orchestrating various components of cellular machinery in response. Both genetic and pharmacological interventions that inhibit the TOR pathway exhibit a similar phenotype, which is not further amplified by CR. In this paper, we present the first comprehensive, computationally derived map of TOR downstream effectors, with the objective of discovering key lifespan mediators, their crosstalk, and high-level organization. We adopt a systematic approach for tracing information flow from the TOR complex and use it to identify relevant signaling elements. By constructing a high-level functional map of TOR downstream effectors, we show that our approach is not only capable of recapturing previously known pathways, but also suggests potential targets for future studies.Information flow scores provide an aggregate ranking of relevance of proteins with respect to the TOR signaling pathway. These rankings must be normalized for degree bias, appropriately interpreted, and mapped to associated roles in pathways. We propose a novel statistical framework for integrating information flow scores, the set of differentially expressed genes in response to rapamycin treatment, and the transcriptional regulatory network. We use this framework to identify the most relevant transcription factors in mediating the observed transcriptional response, and to construct the effective response network of the TOR pathway. This network is hypothesized to mediate life-span extension in response to TOR inhibition. Our approach, unlike experimental methods, is not limited to specific aspects of cellular response. Rather, it predicts transcriptional

  17. Determining firm characteristics and the level of voluntary corporate governance disclosures among Malaysian listed property companies

    Talpur Shabana; Lizam Mohd; Keerio Nazia

    2018-01-01

    This study examined the level of voluntary corporate governance disclosures and the influence of firm characteristics (i.e., firm size, firm age, and firm market listing) on the level of these disclosures among Malaysian property listed companies. The check-list to measure the voluntary corporate governance disclosures was adopted from Malaysian corporate governance index 2011 by Minority Shareholder Watchdog Group (MSWG). The voluntary corporate governance disclosure practices and firm speci...

  18. Corporate governance and earnings quality : evidence from the Malaysian banking sector

    Siniah, Thangamany

    2017-01-01

    This thesis investigates whether corporate governance conformance by Malaysian banks improves their financial reporting quality. It is motivated by the controversies surrounding corporate governance reforms and the calls for systematic research on its efficacy in the post-reform period. Malaysian banks have been subject to international standards of corporate governance since before and after the 1997–1998 Asian Financial Crisis. Malaysia’s common-law tradition, greater level of financial and...

  19. THE IMPACT OF PERSONALITY AND LEADERSHIP STYLES ON LEADING CHANGE CAPABILITY OF MALAYSIAN MANAGERS

    Ali Hussein Alkahtani; Ismael Abu-Jarad; Mohamed Sulaiman; Davoud Nikbin

    2011-01-01

    This study was conducted to investigate the influence of the Big Five Dimensions of personality of the Malaysian Managers and the leadership styles these managers use on their leading change capabilities. Total sample of 105 managers was used in this study. The results of this study revealed that the Malaysian managers tend to enjoy personalities that are conscious and open to experience. These managers tend to use consultative leadership style. However, they use autocratic, democratic and so...

  20. Inter-Religious Dialogue: The Perspective of Malaysian Contemporary Muslim Thinkers

    AEMY ELYANI MAT ZAIN; JAFFARY AWANG; IDRIS ZAKARIA

    2014-01-01

    Malaysia is a country that is rich for the diversity of its people. This diversity can be seen from the aspect of faith, ethnicity, language, culture, and so on. In facing a society that is pluralistic in nature, several initiatives have been taken by the government and non-government bodies in ensuring understanding and unity among Malaysians. Among the initiatives taken are interreligious dialogues. In this regard, many among Malaysian thinkers have proposed some approaches and concepts of ...

  1. Towards Malaysian LADM Country Profile for 2D and 3D Cadastral Registration System

    Zulkifli, N.A.; Abdul Rahman, A.; Jamil, H.; Teng, C.H.; Tan, L.C.; Looi, K.S.; Chan, K.L.; Van Oosterom, P.J.M.

    2014-01-01

    This paper proposes a comprehensive Land Administration Domain Model (LADM, ISO 2012) country profile for 2D and 3D cadastral registration system for Malaysia. The proposed Malaysian country profile is partly based on the existing spatial (including survey) and administrative registration systems, and partly based on new developments inspired by the LADM standard. Within the country profile, an attempt is made to cover all Malaysian land administration related information, which are maintaine...

  2. The political economy of Malaysian federalism: Economic development, public policy and conflict containment

    Jomo, K. S.; Hui, Wee Chong

    2002-01-01

    Conflicts within the Malaysian federation have been rooted in socio-economic disparities and the struggle for control of natural resource rents, which State Governments previously had exclusive control over, as originally provided for by the federal constitution. The advance of fiscal centralization since then has also aggravated federal-state tensions, which have been relatively ignored due to the long-standing Malaysian pre-occupation with inter-ethnic tensions. Inter-regional resource tran...

  3. Covenant Cog or Functional Fourth Estate. A Survey of Malaysian Journalists’ Attitudes towards their Profession

    Rohini SREEKUMAR; Sony JALARAJAN RAJ

    2012-01-01

    In Malaysia, the idealistic notion of the news media as ‘watchdog’ is largely redundant due to the external and institutional realities associated with its functioning in a heavily regulated, monitored and controlled media system. There has been little analysis of Malaysian journalists’ perceptions of their profession. Operating within an authoritarian mediascape, Malaysian journalists have to surrender their journalistic values and principles of practice thereby pervading a culture of self-c...

  4. Collaborative Research between Malaysian and Australian Universities on Learning Analytics: Challenges and Strategies

    Z. Tasir; S. N. Kew; D. West; Z. Abdullah; D. Toohey

    2016-01-01

    Research on Learning Analytics is progressively developing in the higher education field by concentrating on the process of students' learning. Therefore, a research project between Malaysian and Australian Universities was initiated in 2015 to look at the use of Learning Analytics to support the development of teaching practice. The focal point of this article is to discuss and share the experiences of Malaysian and Australian universities in the process of developing the collaborative resea...

  5. Similar taste-nutrient relationships in commonly consumed Dutch and Malaysian foods.

    Teo, Pey Sze; van Langeveld, Astrid W B; Pol, Korrie; Siebelink, Els; de Graaf, Cees; Yan, See Wan; Mars, Monica

    2018-06-01

    Three recent studies showed that taste intensity signals nutrient content. However, current data reflects only the food patterns in Western societies. No study has yet been performed in Asian culture. The Malaysian cuisine represents a mixture of Malay, Chinese and Indian foods. This study aimed to investigate the associations between taste intensity and nutrient content in commonly consumed Dutch (NL) and Malaysian (MY) foods. Perceived intensities of sweetness, sourness, bitterness, umami, saltiness and fat sensation were assessed for 469 Dutch and 423 Malaysian commonly consumed foods representing about 83% and 88% of an individual's average daily energy intake in each respective country. We used a trained Dutch (n = 15) and Malaysian panel (n = 20) with quantitative sensory Spectrum™ 100-point rating scales and reference solutions, R1 (13-point), R2 (33-point) and R3 (67-point). Dutch and Malaysian foods had relatively low mean sourness and bitterness (Malaysian foods (15-point) was higher than that of Dutch foods (8-point). Positive associations were found between sweetness and mono- and disaccharides (R 2  = 0.67 (NL), 0.38 (MY)), between umami and protein (R 2  = 0.29 (NL), 0.26 (MY)), between saltiness and sodium (R 2  = 0.48 (NL), 0.27 (MY)), and between fat sensation and fat content (R 2  = 0.56 (NL), 0.17(MY)) in Dutch and Malaysian foods (all, p < 0.001). The associations between taste intensity and nutrient content are not different between different countries, except for fat sensation-fat content. The two dimensional basic taste-nutrient space, representing the variance and associations between tastes and nutrients, is similar between Dutch and Malaysian commonly consumed foods. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Socioemotional Wealth and Firms’ Control: Evidence from Malaysian Chinese Owned Companies

    Goh, Chin Fei; Rasli, Amran; Tan, Owee Kowang; Choi, Sang Long

    2015-01-01

    This paper explores how the preservation of socioemotional wealth can be manifested in the control and corporate governance of Malaysian Chinese firms. Using panel data from the Industrial Products index of the Bursa Malaysia (the Malaysian stock exchange) during 2003-2006, we show that the ingrained ‘life-raft values’ among overseas Chinese entrepreneurs can be associated with the preservation of their socioemotional wealth, and thus they prioritize control over their firms. Additionally, we...

  7. Effects Of Rotation On Auditor Independence And Quality Of Audit Service In Malaysian Banking Industry

    Kabiru Isa Dandago

    2012-12-01

    means for ensuring auditor independence and high audit quality in the Malaysian banking industry. In the absence of statutory/mandatory requirement for auditor rotation, it is recommended that the Malaysian banking institutions should be carefully evaluating the impact auditor rotation would have on the quality of audit work on their current and future financial statements, as they decide whether to rotate their auditors or not.

  8. Test of Weak Form Efficiency: An Empirical Study of the Malaysian Foreign Exchange Market

    Lim, Pei Mun

    2011-01-01

    This paper empirically tests the Efficient Market Hypothesis (EMH) in the weak sense for the Malaysian foreign exchange market. The hypothesis is tested using two ways. First is by testing the random walk hypothesis based on individual unit root test and second is by testing the profitability of simple technical trading rules. The study covers the high frequency daily data from January 1997 to December 2010 and the spot exchange rates are quoted as Malaysian Ringgit per unit of US Dollar. Due...

  9. Consumption intention toward ethnic food: determinants of Dayak food choice by Malaysians

    Ting, Hiram; Tan, Sharon; Alexandra Nastassia, John

    2017-01-01

    Background: The awareness and trying of ethnic cuisine have increased due to the developing exchange of trade, movement of ethnicities across the globe, and tourist traveling opportunities. More people consume ethnic food for the appreciation of the culture and taste. Although the Dayaks are the largest indigenous group in Malaysia, little is done to date to explicate why Malaysians consume Dayak food. The present study aims to investigate the Dayak food choice of non-Dayak Malaysians and to ...

  10. The Malaysian general elections of 2013: the last attempt at secular-inclusive nation-building?

    Noor, Farish A.

    2013-01-01

    "This paper looks at the Malaysian General Election campaign of 2013, and focuses primarily on the 1Malaysia project that was foregrounded by the administration of Prime Minister Najib Razak. It compares the 1Malaysia project with other projects aimed at nation-building, such as the Wawasan 2020 project of former Prime Minister Mahathir and the Islam Hadari project of former Prime Minister Badawi; and asks if 1Malaysia was truly an attempt at building a sense of Malaysian nationhood based on ...

  11. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.

    Tang, Guomei; Gudsnuk, Kathryn; Kuo, Sheng-Han; Cotrina, Marisa L; Rosoklija, Gorazd; Sosunov, Alexander; Sonders, Mark S; Kanter, Ellen; Castagna, Candace; Yamamoto, Ai; Yue, Zhenyu; Arancio, Ottavio; Peterson, Bradley S; Champagne, Frances; Dwork, Andrew J; Goldman, James; Sulzer, David

    2014-09-03

    Developmental alterations of excitatory synapses are implicated in autism spectrum disorders (ASDs). Here, we report increased dendritic spine density with reduced developmental spine pruning in layer V pyramidal neurons in postmortem ASD temporal lobe. These spine deficits correlate with hyperactivated mTOR and impaired autophagy. In Tsc2 ± ASD mice where mTOR is constitutively overactive, we observed postnatal spine pruning defects, blockade of autophagy, and ASD-like social behaviors. The mTOR inhibitor rapamycin corrected ASD-like behaviors and spine pruning defects in Tsc2 ± mice, but not in Atg7(CKO) neuronal autophagy-deficient mice or Tsc2 ± :Atg7(CKO) double mutants. Neuronal autophagy furthermore enabled spine elimination with no effects on spine formation. Our findings suggest that mTOR-regulated autophagy is required for developmental spine pruning, and activation of neuronal autophagy corrects synaptic pathology and social behavior deficits in ASD models with hyperactivated mTOR. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors

    Gianluigi Zaza

    2013-01-01

    Full Text Available The mammalian target of rapamycin inhibitors (mTOR-I, sirolimus and everolimus, are immunosuppressive drugs largely used in renal transplantation. The main mechanism of action of these drugs is the inhibition of the mammalian target of rapamycin (mTOR, a regulatory protein kinase involved in lymphocyte proliferation. Additionally, the inhibition of the crosstalk among mTORC1, mTORC2, and PI3K confers the antineoplastic activities of these drugs. Because of their specific pharmacological characteristics and their relative lack of nephrotoxicity, these inhibitors are valid option to calcineurine inhibitors (CNIs for maintenance immunosuppression in renal transplant recipients with chronic allograft nephropathy. However, as other immunosuppressive drugs, mTOR-I may induce the development of several adverse effects that need to be early recognized and treated to avoid severe illness in renal transplant patients. In particular, mTOR-I may induce systemic nonnephrological side effects including pulmonary toxicity, hematological disorders, dysmetabolism, lymphedema, stomatitis, cutaneous adverse effects, and fertility/gonadic toxicity. Although most of the adverse effects are dose related, it is extremely important for clinicians to early recognize them in order to reduce dosage or discontinue mTOR-I treatment avoiding the onset and development of severe clinical complications.

  13. Genetic evaluation for TOR1-A (DYT1 in Brazilian patients with dystonia

    Carlos Henrique F. Camargo

    2014-10-01

    Full Text Available Several genes have been mapped in families or in sporadic cases of dystonia. TOR1-A (DYT1 gene was linked to isolated dystonia. Objective To associate clinical information of patients with dystonia with the TOR1-A gene mutations. Method Eighty-eight patients with dystonia in cervical area (focal, segmental, multifocal and generalized were recruited at Movement Disorders Clinic of Hospital de Clínicas of the Federal University of Paraná between June of 2008 and June of 2009. They were submitted to the clinical evaluation. DNA was extract from blood and submitted at analysis to TOR1-A mutations by PCR according standard protocols. Results Two patients had c.907GAGdel mutation on TOR1-A gene. These patients, with familial history of dystonia, started his symptoms by legs and had secondary generalization. Conclusion We can suggest that analysis for TOR1-A mutations should be performed only in patients with early onset, generalized and familial dystonia.

  14. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.

    Jian-Qiu Wang

    Full Text Available Nijmegen breakage syndrome (NBS is a chromosomal-instability syndrome. The NBS gene product, NBS1 (p95 or nibrin, is a part of the Mre11-Rad50-NBS1 complex. SIN1 is a component of the mTOR/Rictor/SIN1 complex mediating the activation of Akt. Here we show that NBS1 interacted with mTOR, Rictor, and SIN1. The specific domains of mTOR, Rictor, or SIN1 interacted with the internal domain (a.a. 221-402 of NBS1. Sucrose density gradient showed that NBS1 was located in the same fractions as the mTOR/Rictor/SIN1 complex. Knockdown of NBS1 decreased the levels of phosphorylated Akt and its downstream targets. Ionizing radiation (IR increased the NBS1 levels and activated Akt activity. These results demonstrate that NBS1 interacts with the mTOR/Rictor/SIN1 complex through the a.a. 221-402 domain and contributes to the activation of Akt activity.

  15. The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma

    Matsuoka, Tasuku; Yashiro, Masakazu

    2014-01-01

    The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is one of the key signaling pathways induced by various receptor-tyrosine kinases. Accumulating evidence shows that this pathway is an important promoter of cell growth, metabolism, survival, metastasis, and resistance to chemotherapy. Genetic alterations in the PI3K/Akt/mTOR pathway in gastric carcinoma have often been demonstrated. Many kinds of molecular targeting therapies are currently undergoing clinical testing in patients with solid tumors. However, with the exception of the ErbB2-targeting antibody, targeting agents, including PI3K/Akt/mTOR inhibitors, have not been approved for treatment of patients with gastric carcinoma. This review summarizes the current knowledge on PI3K/Akt/mTOR signaling in the pathogenesis of gastric carcinoma and the possible therapeutic targets for gastric carcinoma. Improved knowledge of the PI3K/Akt/mTOR pathway in gastric carcinoma will be useful in understanding the mechanisms of tumor development and for identifying ideal targets of anticancer therapy for gastric carcinoma

  16. The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma

    Matsuoka, Tasuku [Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585 (Japan); Yashiro, Masakazu, E-mail: m9312510@med.osaka-cu.ac.jp [Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585 (Japan); Oncology Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585 (Japan)

    2014-07-07

    The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is one of the key signaling pathways induced by various receptor-tyrosine kinases. Accumulating evidence shows that this pathway is an important promoter of cell growth, metabolism, survival, metastasis, and resistance to chemotherapy. Genetic alterations in the PI3K/Akt/mTOR pathway in gastric carcinoma have often been demonstrated. Many kinds of molecular targeting therapies are currently undergoing clinical testing in patients with solid tumors. However, with the exception of the ErbB2-targeting antibody, targeting agents, including PI3K/Akt/mTOR inhibitors, have not been approved for treatment of patients with gastric carcinoma. This review summarizes the current knowledge on PI3K/Akt/mTOR signaling in the pathogenesis of gastric carcinoma and the possible therapeutic targets for gastric carcinoma. Improved knowledge of the PI3K/Akt/mTOR pathway in gastric carcinoma will be useful in understanding the mechanisms of tumor development and for identifying ideal targets of anticancer therapy for gastric carcinoma.

  17. Immunohistochemical Investigation of HER/AKT/mTOR Pathway and Cellular Adhesion Molecules in Urothelial Carcinomas

    Nikolaos Koletsas

    2017-01-01

    Full Text Available Background. Several investigators have suggested the possibility that the expression of both EGFR and HER2 could be utilized for molecularly targeted therapy in urinary bladder cancer. We tried to evaluate the expression of HER2 and EGFR and activation of the AKT/PTEN/mTOR pathway in urothelial carcinomas and if there is any association between them and cellular adhesion molecules (CAMs. Materials and Methods. Forty-one paraffin-embedded urothelial cancer tissue blocks were collected. Immunostains for HER2, EGFR, MIB1, phospho-AKT, PTEN, phospho-mTOR, e-cadherin, p-cadherin, and b-catenin were performed on tissue microarrays sections. The immunohistochemical results were correlated with clinicopathological parameters. Results. The overexpression of HER2 was found in 19.6% of the cases and it was associated with high grade tumors with a high mitotic index and phosphorylation of AKT and mTOR. Muscle-invasive tumors presented both cytoplasmic and nuclear losses of PTEN expression. There was no association between HER/AKT/mTOR pathway activation and CAM expression. Although cadherins were often coexpressed, only p-cadherin immunoreactivity was associated with tumor grade and high proliferative index. Conclusions. HER2 overexpression is found in a respective proportion of urothelial carcinomas. P-cadherin expression is associated with high grade UCs but it is not affected by HER2 overexpression or by activation of HER/AKT/mTOR pathway.

  18. Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response.

    Wang, Pengcheng; Zhao, Yang; Li, Zhongpeng; Hsu, Chuan-Chih; Liu, Xue; Fu, Liwen; Hou, Yueh-Ju; Du, Yanyan; Xie, Shaojun; Zhang, Chunguang; Gao, Jinghui; Cao, Minjie; Huang, Xiaosan; Zhu, Yingfang; Tang, Kai; Wang, Xingang; Tao, W Andy; Xiong, Yan; Zhu, Jian-Kang

    2018-01-04

    As sessile organisms, plants must adapt to variations in the environment. Environmental stress triggers various responses, including growth inhibition, mediated by the plant hormone abscisic acid (ABA). The mechanisms that integrate stress responses with growth are poorly understood. Here, we discovered that the Target of Rapamycin (TOR) kinase phosphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress response in unstressed plants. This phosphorylation disrupts PYL association with ABA and with PP2C phosphatase effectors, leading to inactivation of SnRK2 kinases. Under stress, ABA-activated SnRK2s phosphorylate Raptor, a component of the TOR complex, triggering TOR complex dissociation and inhibition. Thus, TOR signaling represses ABA signaling and stress responses in unstressed conditions, whereas ABA signaling represses TOR signaling and growth during times of stress. Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and stress responses. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie.

    Parker, Joseph; Struhl, Gary

    2015-10-01

    Organ growth is controlled by patterning signals that operate locally (e.g., Wingless/Ints [Wnts], Bone Morphogenetic Proteins [BMPs], and Hedgehogs [Hhs]) and scaled by nutrient-dependent signals that act systemically (e.g., Insulin-like peptides [ILPs] transduced by the Target of Rapamycin [TOR] pathway). How cells integrate these distinct inputs to generate organs of the appropriate size and shape is largely unknown. The transcriptional coactivator Yorkie (Yki, a YES-Associated Protein, or YAP) acts downstream of patterning morphogens and other tissue-intrinsic signals to promote organ growth. Yki activity is regulated primarily by the Warts/Hippo (Wts/Hpo) tumour suppressor pathway, which impedes nuclear access of Yki by a cytoplasmic tethering mechanism. Here, we show that the TOR pathway regulates Yki by a separate and novel mechanism in the Drosophila wing. Instead of controlling Yki nuclear access, TOR signaling governs Yki action after it reaches the nucleus by allowing it to gain access to its target genes. When TOR activity is inhibited, Yki accumulates in the nucleus but is sequestered from its normal growth-promoting target genes--a phenomenon we term "nuclear seclusion." Hence, we posit that in addition to its well-known role in stimulating cellular metabolism in response to nutrients, TOR also promotes wing growth by liberating Yki from nuclear seclusion, a parallel pathway that we propose contributes to the scaling of wing size with nutrient availability.

  20. Target of rapamycin (TOR) plays a critical role in triacylglycerol accumulation in microalgae.

    Imamura, Sousuke; Kawase, Yasuko; Kobayashi, Ikki; Sone, Toshiyuki; Era, Atsuko; Miyagishima, Shin-Ya; Shimojima, Mie; Ohta, Hiroyuki; Tanaka, Kan

    2015-10-01

    Most microalgae produce triacylglycerol (TAG) under stress conditions such as nitrogen depletion, but the underlying molecular mechanism remains unclear. In this study, we focused on the role of target of rapamycin (TOR) in TAG accumulation. TOR is a serine/threonine protein kinase that is highly conserved and plays pivotal roles in nitrogen and other signaling pathways in eukaryotes. We previously constructed a rapamycin-susceptible Cyanidioschyzon merolae, a unicellular red alga, by expressing yeast FKBP12 protein to evaluate the results of TOR inhibition (Imamura et al. in Biochem Biophys Res Commun 439:264-269, 2013). By using this strain, we here report that rapamycin-induced TOR inhibition results in accumulation of cytoplasmic lipid droplets containing TAG. Transcripts for TAG synthesis-related genes, such as glycerol-3-phosphate acyltransferase and acyl-CoA:diacylglycerol acyltransferase (DGAT), were increased by rapamycin treatment. We also found that fatty acid synthase-dependent de novo fatty acid synthesis was required for the accumulation of lipid droplets. Induction of TAG and up-regulation of DGAT gene expression by rapamycin were similarly observed in the unicellular green alga, Chlamydomonas reinhardtii. These results suggest the general involvement of TOR signaling in TAG accumulation in divergent microalgae.

  1. Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism.

    Varela, Luis; Martínez-Sánchez, Noelia; Gallego, Rosalía; Vázquez, María J; Roa, Juan; Gándara, Marina; Schoenmakers, Erik; Nogueiras, Rubén; Chatterjee, Krishna; Tena-Sempere, Manuel; Diéguez, Carlos; López, Miguel

    2012-06-01

    Hyperthyroidism is characterized in rats by increased energy expenditure and marked hyperphagia. Alterations of thermogenesis linked to hyperthyroidism are associated with dysregulation of hypothalamic AMPK and fatty acid metabolism; however, the central mechanisms mediating hyperthyroidism-induced hyperphagia remain largely unclear. Here, we demonstrate that hyperthyroid rats exhibit marked up-regulation of the hypothalamic mammalian target of rapamycin (mTOR) signalling pathway associated with increased mRNA levels of agouti-related protein (AgRP) and neuropeptide Y (NPY), and decreased mRNA levels of pro-opiomelanocortin (POMC) in the arcuate nucleus of the hypothalamus (ARC), an area where mTOR co-localizes with thyroid hormone receptor-α (TRα). Central administration of thyroid hormone (T3) or genetic activation of thyroid hormone signalling in the ARC recapitulated hyperthyroidism effects on feeding and the mTOR pathway. In turn, central inhibition of mTOR signalling with rapamycin in hyperthyroid rats reversed hyperphagia and normalized the expression of ARC-derived neuropeptides, resulting in substantial body weight loss. The data indicate that in the hyperthyroid state, increased feeding is associated with thyroid hormone-induced up-regulation of mTOR signalling. Furthermore, our findings that different neuronal modulations influence food intake and energy expenditure in hyperthyroidism pave the way for a more rational design of specific and selective therapeutic compounds aimed at reversing the metabolic consequences of this disease. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  2. Psychological traits underlying different killing methods among Malaysian male murderers.

    Kamaluddin, Mohammad Rahim; Shariff, Nadiah Syariani; Nurfarliza, Siti; Othman, Azizah; Ismail, Khaidzir H; Mat Saat, Geshina Ayu

    2014-04-01

    Murder is the most notorious crime that violates religious, social and cultural norms. Examining the types and number of different killing methods that used are pivotal in a murder case. However, the psychological traits underlying specific and multiple killing methods are still understudied. The present study attempts to fill this gap in knowledge by identifying the underlying psychological traits of different killing methods among Malaysian murderers. The study adapted an observational cross-sectional methodology using a guided self-administered questionnaire for data collection. The sampling frame consisted of 71 Malaysian male murderers from 11 Malaysian prisons who were selected using purposive sampling method. The participants were also asked to provide the types and number of different killing methods used to kill their respective victims. An independent sample t-test was performed to establish the mean score difference of psychological traits between the murderers who used single and multiple types of killing methods. Kruskal-Wallis tests were carried out to ascertain the psychological trait differences between specific types of killing methods. The results suggest that specific psychological traits underlie the type and number of different killing methods used during murder. The majority (88.7%) of murderers used a single method of killing. Multiple methods of killing was evident in 'premeditated' murder compared to 'passion' murder, and revenge was a common motive. Examples of multiple methods are combinations of stabbing and strangulation or slashing and physical force. An exception was premeditated murder committed with shooting, when it was usually a single method, attributed to the high lethality of firearms. Shooting was also notable when the motive was financial gain or related to drug dealing. Murderers who used multiple killing methods were more aggressive and sadistic than those who used a single killing method. Those who used multiple methods or

  3. Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in Arabidopsis.

    Xiong, Fangjie; Zhang, Rui; Meng, Zhigang; Deng, Kexuan; Que, Yumei; Zhuo, Fengping; Feng, Li; Guo, Sundui; Datla, Raju; Ren, Maozhi

    2017-01-01

    The components of the target of rapamycin (TOR) signaling pathway have been well characterized in heterotrophic organisms from yeast to humans. However, because of rapamycin insensitivity, embryonic lethality in tor null mutants and a lack of reliable ways of detecting TOR protein kinase in higher plants, the key players upstream and downstream of TOR remain largely unknown in plants. Using engineered rapamycin-sensitive Binding Protein 12-2 (BP12-2) plants, the present study showed that combined treatment with rapamycin and active-site TOR inhibitors (asTORis) results in synergistic inhibition of TOR activity and plant growth in Arabidopsis. Based on this system, we revealed that TOR signaling plays a crucial role in modulating the transition from heterotrophic to photoautotrophic growth in Arabidopsis. Ribosomal protein S6 kinase 2 (S6K2) was identified as a direct downstream target of TOR, and the growth of TOR-suppressed plants could be rescued by up-regulating S6K2. Systems, genetic, and biochemical analyses revealed that Brassinosteriod Insensitive 2 (BIN2) acts as a novel downstream effector of S6K2, and the phosphorylation of BIN2 depends on TOR-S6K2 signaling in Arabidopsis. By combining pharmacological with genetic and biochemical approaches, we determined that the TOR-S6K2-BIN2 signaling pathway plays important roles in regulating the photoautotrophic growth of Arabidopsis. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

  4. Innovation in small and medium sized enterprises (SMEs) in the Malaysian information technology (IT) industry

    Fatimah Mohd Amin

    2001-01-01

    The aim of this study is to examine innovative activities in small and medium enterprises (SMEs) in the Malaysian information technology (IT) industry. This study addresses three research questions: 1. What is the innovation pattern among SMEs in the Malaysian IT industry? 2. How significant is interactive learning between SMEs in the Malaysian IT industry and other agents in the innovation system? and 3. What is the role of the government in promoting innovation among SMEs in the Malaysian IT industry? Two approaches were taken to collect data for this study, that is, mail survey and face-to-face interviews. Based on findings from this study, the SMEs in the Malaysian IT industry were divided into four categories, namely, highly innovative, innovative, inventive, and non innovative. The patterns of knowledge acquisition and interactive learning vary among the different categories of firms, and on the whole, vertical linkages with suppliers were found to be the most significant. Finally, support through the provision of funding was considered to be among the most important roles of the government in promoting innovation in SMEs in the Malaysian IT industry. (author)

  5. Proceedings in a disciplinary action at the Malaysian Medical Council.

    Mahmud, M N

    2005-08-01

    Members of the medical profession are expected to be well aware and abide by the revised code of ethics adopted by the Malaysian Medical Council on 9th December 1986. Under the Act Council may, in the exercise of its disciplinary jurisdiction, impose punishments related to misconduct or malpractices. When a complaint or information is made against any practitioner, the President shall forward such complaint to the Chairman of the Preliminary Investigation Committee. The procedure of the disciplinary inquiry is not exactly like those in the court of law but the same principle of justice is adhered to and all evidence used to make a decision must only be those that are admissible in accordance with the rule of evidence.

  6. ESTIMATION OF AGING EFFECTS OF PILES IN MALAYSIAN OFFSHORE LOCATIONS

    JERIN M. GEORGE

    2017-04-01

    Full Text Available An increasing demand for extending life and subsequently higher loading requirements of offshore jacket platforms are among the key problems faced by the offshore industry. The Aging effect has been proved to increase the axial capacity of piles, but proper methods to estimate and quantify these effects have not been developed. Borehole data from ten different Malaysian offshore locations have been analysed and they were employed to estimate the setup factor for different locations using AAU method. The setup factors found were used in the Skov and Denver equation to calculate capacity ratios of the offshore piles. The study showed that there will be an average improvement in the axial capacity of offshore piles by 42.2% and 34.9% for clayey and mixed soils respectively after a time equal to the normal design life (25 years of a jacket platform.

  7. FRAGMENTATION ISSUE IN MALAYSIAN INDUSTRIALISED BUILDING SYSTEM (IBS PROJECTS

    MOHD NASRUN MOHD NAWI

    2014-02-01

    Full Text Available As a developing country, Malaysian is currently driving for implementing a new or modern construction method, the Industrialised Building System (IBS, as an alternative towards enhancing construction performance. Currently, most of the IBS project developments in Malaysia are still conducted by using the traditional construction process approach. This traditional construction process has been widely criticised for its fragmented approach to project delivery and its failure to form effective teams thus created a number of issues such as reworks, time delay, rising costs, lack of communication and coordination, and wastages. This paper through literature review aims to highlight this fragmentation issue and clarify how far it affects the process of IBS implementation. Suggestions on how an integrated approach in design and construction in order to minimise the fragmentation gaps will be concluded.

  8. Factor structure of the Body Appreciation Scale among Malaysian women.

    Swami, Viren; Chamorro-Premuzic, Tomas

    2008-12-01

    The present study examined the factor structure of a Malay version of the Body Appreciation Scale (BAS), a recently developed scale for the assessment of positive body image that has been shown to have a unidimensional structure in Western settings. Results of exploratory and confirmatory factor analyses based on data from community sample of 591 women in Kuala Lumpur, Malaysia, failed to support a unidimensional structure for the Malay BAS. Results of a confirmatory factor analysis suggested two stable factors, which were labelled 'General Body Appreciation' and 'Body Image Investment'. Multi-group analysis showed that the two-factor structure was invariant for both Malaysian Malay and Chinese women, and that there were no significant ethnic differences on either factor. Results also showed that General Body Appreciation was significant negatively correlated with participants' body mass index. These results are discussed in relation to possible cross-cultural differences in positive body image.

  9. Exploring Opportunities for Sustainability in the Malaysian Palm Oil Industry

    Padfield, Rory; Hansen, Sune Balle; Preece, Christopher

    2011-01-01

    The global thirst for vegetable oil can be regarded as one of the greatest environmental challenges of the 21st Century and interest has intensified with the prospect of biofuels. Palm oil has risen to become the dominant player on the vegetable oil market – and the main recipient of environmental...... scrutiny. Focusing specifically on the Malaysian context, this paper analyses the major environmental, social and economic impacts associated with palm oil production. Drawing on recently published research, publicly available data and a comparison made with a recent sustainability initiative undertaken...... by the hydropower industry – an equally controversial and highly scrutinised sector – it is argued that the full extent of the impacts of palm oil should be acknowledged by those on both sides of the debate. Moreover, it is argued that by moving towards a less polarised version of the palm oil narrative and one...

  10. Knowledge Management In Malaysian Nuclear Agency: The first 40 years

    Habibah Adnan; Norzehan Ngadiron; Iberahim Ali

    2012-01-01

    This paper gives an overview of nuclear knowledge management practices in Malaysian Nuclear Agency (Nuclear Malaysia) in the first 40 years of its operation. Nuclear Malaysia is established in 1972 and its main responsibility is to promote the application of nuclear technology in various socioeconomic sectors including industry, medical, agriculture, manufacturing, health, radiation safety and the environment. Nuclear Malaysia's core competency is R and D in nuclear science and technology. The explanation emphasizes on the activities and challenges in implementing NKM at the Nuclear Malaysia and in particular; nuclear knowledge management practices, the needs for Nuclear Malaysia to strengthen his KM activities and the evolvement and development of KM to enhance the ability of the organization. (Author)

  11. Internet Financial and Environmental Disclosures by Malaysian Companies

    Ali Saleh Alarussi

    2009-06-01

    Full Text Available This paper investigates whether determinants of financial disclosure are similar to environmental disclosure through the Internet. In other words, this paper examines the relationship between Internet financial disclosure (IFD, Internet environmental disclosures (IED and six variables, namely, ethnic of chief executive officer (CEO, leverage, level of technology, listing status, profitability, and firm size. Six hypotheses formulated in this study were analyzed using data collected from the websites of 189 Malaysian listed companies in 2006. The results indicate that level of technology, ethnic of CEO and firm size are significant factors in explaining both IFD and IED. It is also observed that listing status is positively related to the level of IFD but not IED. On the other hand, profitability is significant factor in explaining the level of IED but not IFD. Finally, leverage is not significantly related to both IFD and IED.

  12. Perceived health status and daily activity participation of older Malaysians.

    Ng, Sor Tho; Tengku-Aizan, Hamid; Tey, Nai Peng

    2011-07-01

    This article investigates the influence of perceived health status on the daily activity participation of older Malaysians. Data from the Survey on Perceptions of Needs and Problems of the Elderly, which was conducted in 1999, were used. The negative binomial regression results show that older persons with good perceived health status reported more varieties of daily activity participation, especially among the uneducated and those with below-average self-esteem. The multinomial logistic regression model suggests that older persons with good perceived health status tended to engage daily in paid work only or with leisure activities, whereas those perceived to have poor health were more likely to engage in leisure activities only or leisure and family role activities. Promotion of a healthy lifestyle at a younger age encourages every person to monitor and take responsibility for their own health, which is a necessary strategy to ensure active participation at an older age, and thus improve their well-being.

  13. Preliminary study on improving safety culture in Malaysian nuclear industries

    Ibrahim, Sabariah Kader; Lee, Y. E.

    2012-01-01

    This paper presents preliminary study on safety culture and its implementation in Malaysian nuclear industries by realizing the importance of safety culture; identification of important safety culture attributes; safety culture assessment and the practices to incorporate the identified safety culture attributes in organization. The first section of this paper explains the terms and definitions related to safety culture. Second, for the realization of importance of safety culture in organization, the international operational experiences emphasizing the importance of safety culture are described. Third, important safety culture attributes which are frequently cited in literature are provided. Fourth, methods to assess safety culture in operating organization are described. Finally, the practices to enhance the safety culture in an organization are discussed

  14. Preliminary study on improving safety culture in Malaysian nuclear industries

    Ibrahim, Sabariah Kader [KAIST, Daejeon (Korea, Republic of); Lee, Y. E. [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2012-10-15

    This paper presents preliminary study on safety culture and its implementation in Malaysian nuclear industries by realizing the importance of safety culture; identification of important safety culture attributes; safety culture assessment and the practices to incorporate the identified safety culture attributes in organization. The first section of this paper explains the terms and definitions related to safety culture. Second, for the realization of importance of safety culture in organization, the international operational experiences emphasizing the importance of safety culture are described. Third, important safety culture attributes which are frequently cited in literature are provided. Fourth, methods to assess safety culture in operating organization are described. Finally, the practices to enhance the safety culture in an organization are discussed.

  15. International Markets: Malaysian Construction Contractors and the Stage Theory

    Ahmed Awil

    2012-11-01

    Full Text Available Reduced demand for services, lack of finances for projects and idle resources at homehave resulted in loss of business for Malaysian construction contractors. Among the optionsthat are explored in this paper is internationalisation of services to help the contractorsgainfully employ their resources and diversify their markets. Integration of worldmarkets, faster transportation and improved means of communication have made it possiblefor contractors to undertake work in international markets. It was found that contractorswere motivated to internationalise by need to make the firm a viable one byconsidering the long-term profitability. Reputation and size of the firm were found to befactors that help contractors in winning contracts overseas. Most non-exporters were concernedwith provision of market intelligence and export credit finance. It was found thatproviding relevant market information, accessible to both exporter and non-exporters, canhelp firms make informed decisions. Any assistance provided should match the firm to thestage the firm has reached in exporting

  16. The grotesque female in Malaysian poems: shaping the migrant's psyche.

    DMani, Sheba

    2011-12-01

    The works of Malaysian poet, Wong Phui Nam's Against the Wilderness (vii) China bride and Variations on a Birthday Theme (iv) Kali, illustrate a bride and a mother in terrifying images. Wong's stylistic form of representing the female body through startling images of inversion and degradation evoke feelings of unease. The suspension between the known and the unknown causes a bewildering reality verging on madness. Interpreted through the lens of the carnivalesque, specifically, the grotesque body, festive language and parody, I attempt to reconstruct the psyche of the Chinese migrant which underpins these poems. The migrant who arrived in Malaya during the colonial era in the early nineteenth century faced political and social struggles in adapting to a new land. In the poems, the migrant juxtaposes his position to a female and uses the female body as a site of contention to intensify the torment of the psyche and to reflect the despair of the Chinese in Malaysia.

  17. Roadmap for biofertilizer development project at Malaysian Nuclear Agency

    Khairuddin Abdul Rahim; Ahmad Nazrul Abd Wahid; Phua Choo Kwai Hoe; Pauline Liew Woan Ying; Ahamad Sahali Mardi; Mat Rasol Awang

    2007-01-01

    This paper discusses the roadmap for the Biofertilizer Development Project conducted at the Malaysian Nuclear Agency (Nuclear Malaysia). The project started in 2003 and scheduled to end in 2008. Biofertilizer refers to living microorganisms or materials that contain living microorganisms that contributes to improvement in plant nutrition, soil fertility and crop productivity. The main components of the project are (a) biofertilizer substrate or carrier development, (b) biofertilizer inoculum development based on local indigenous microorganisms (c) biofertilizer product formulation and innovation, and (d) evaluation of efficiency of biofertilizer products on crops under different cropping systems, including under modern agriculture under soilless system. The above components may involve nuclear technology, viz, use of ionising radiation and the use of isotopic tracers. The paper also discusses local and international linkages, including with Forum for Nuclear Cooperation in Asia (FNCA) and the industry, and aspects of commercialisation and technology transfer. (Author)

  18. Is candlestick continuation patterns applicable in Malaysian stock market?

    Chin Chee-Ling

    2017-01-01

    Full Text Available Technical analysis is deemed to be an anathema to the modern finance theory as it contradicts with the efficient market hypothesis, typically the weak form market efficiency which forbids the utilization of past prices and trading volume data to predict future market movement. However, the technical indicator of candlestick trading strategy is widely applied by traders for short term investment. This study thus investigates on the predictive power of candlestick charting which concentrates on the application of continuation patterns in Malaysian stock market from 2000 to 2014. Skewness adjusted t-test is employed to test the statistical significance of candlesticks’ profitability. After taking into account the transaction costs, sub-sample, and out-of-sample test, the findings show that only Falling Window pattern after a prevailing downtrend shows predictive power with bearish signals indicated significantly during the 5-day holding period.

  19. Religiosity and Volunteering Intention Among Undergraduate Malaysian Muslim Students

    Sallam A.A.A.

    2018-01-01

    Full Text Available This paper deals with the question: To what extent do religiosity characteristics, contribute to the influence of volunteering intention among Malaysian Muslim students during disasters? To answer this research question, we focused the students in public universities. The finding concerns found that religiosity increases the likelihood of volunteering intention, implying that religious affiliation of youth increases the likelihood of volunteering. This is in line with previous research, that religious attendance is related positively to volunteering. These results confirm the idea that support of the religious attributes community plays quite a large role in volunteering process. However, it a bear that volunteering is not only dependent on religious community, but also on individual motivation.

  20. Religiosity and Volunteering Intention among Undergraduate Malaysian Muslim Students

    Ali Sallam Abdullah AbdulElah

    2018-01-01

    Full Text Available This paper deals with the question: To what extent do religiosity characteristics, contribute to the influence of volunteering intention among Malaysian Muslim students during disasters? To answer this research question, we focused the students in public universities. The finding concerns found that religiosity increases the likelihood of volunteering intention, implying that religious affiliation of youth increases the likelihood of volunteering. This is in line with previous research, that religious attendance is related positively to volunteering. These results confirm the idea that support of the religious attributes community plays quite a large role in volunteering process.. However, it a bear that volunteering is not only dependent on religious community, but also on individual motivation.

  1. In Search of Internationalized Operator Interface Displays in Process Control: A Comparison among Malaysian, Singaporean and Chinese

    Liang, Sheau-Farn M; Khalid, Halimahtun M; Taha, Zahari; Plocher, Thomas

    2004-01-01

    .... In this study, 266 Malaysian operators from various industrial sites in Malaysia were recruited to answer a computerized questionnaire regarding their perceptions of colors, shapes and orientations...

  2. Anatomy learning styles and strategies among Jordanian and Malaysian medical students: the impact of culture on learning anatomy.

    Mustafa, Ayman G; Allouh, Mohammed Z; Mustafa, Intisar G; Hoja, Ibrahim M

    2013-07-01

    The study aims to investigate anatomy learning styles and strategies of Jordanian and Malaysian medical students at the Jordan University of Science and Technology. The study is a cross-sectional questionnaire-based study. Students' responses for the questionnaire were numerically coded, and the results were analyzed to reveal statistically significant differences between Jordanian and Malaysian students. The results showed that Jordanian medical students were less interested in using cadavers in learning anatomy than Malaysian medical students. However, similar to their Malaysian counterparts, they prefer to employ other tools to learn anatomy like plastinated models and Internet-based resources. In addition to the aforementioned tools, Malaysian students were more interested in using cross-sectional images and making their own revision cards. Both Jordanian and Malaysian medical students were more interested in learning anatomy through clinical cases, and by system rather than by region. Moreover, it was revealed that Jordanian medical students learn anatomy more efficiently when they formulate a general view of a particular topic. Both Jordanian and Malaysian medical students also relied on reciting definitions and memorizing facts to learn anatomy. The study also reported significant differences between Jordanian and Malaysian students' perspectives on learning anatomy. The findings of the study suggest that Jordanian and Malaysian medical students posses different cultures of learning. Jordanian anatomy instructors need to consider these different learning cultures when they prepare their instructional methods and teaching materials to fulfill the educational needs of their culturally diverse students.

  3. Job satisfaction of Malaysian registered nurses: a qualitative study.

    Atefi, Narges; Abdullah, Khatijah L; Wong, Li P

    2016-01-01

    Job satisfaction is an important factor in health care settings. Strong empirical evidence supports a causal relationship between job satisfaction, patient safety and quality of care. However, there have not been any studies exploring the job satisfaction of Malaysian nurses. The main purpose of this qualitative descriptive study was to explore the factors related to feelings of job satisfaction as well as job dissatisfaction experienced by registered nurses in Malaysia. A convenient sample of 46 Malaysian nurses recruited from a large hospital (number of beds = 895) participated in the study. A total of seven focus group discussions were conducted with nurses from surgical, medical and critical care wards. A semi-structured interview guide was used to facilitate the interviews, which were audio-recorded, transcribed verbatim and checked. The transcripts were used as data and were analysed using a thematic approach. The study identified three main themes that influenced job satisfaction: (1) nurses' personal values and beliefs; (2) work environment factors and (3) motivation factors. Concerning the nurses' personal values and beliefs, the ability to help people made the nurses felt honoured and happy, which indirectly contributed to job satisfaction. For work environment factors, team cohesion, benefit and reward, working conditions play an important role in the nurses' job satisfaction. Motivation factors, namely, professional development and clinical autonomy contributed to job satisfaction. It is important for nurse leaders to provide more rewards, comfortable work environments and to understand issues that affect nurses' job satisfaction. Our findings highlight the importance of factors that can improve nurses' job satisfaction. The study provides basic information for hospital administrators in planning effective and efficient policies to improve nursing job satisfaction in order to increase the quality of patient care and decrease nursing turnover. © 2014

  4. Energy consumption of electricity end uses in Malaysian historic buildings

    Kamaruzzaman, Syahrul N.; Edwards, Rodger E.; Zawawi, Emma M.A.

    2007-07-15

    Malaysia has inherited hundreds of heritage buildings from the past including those from the Indian, Chinese and Colonial eras apart from the indigenous traditional buildings. These buildings have the most unique ecstatic value from the viewpoint of architecture, culture, art, etc. Malaysian economy boom in 1980s spurred the need for more buildings especially in large cities. As a result, most of the historic buildings have been converted and transformed into commercial use. As reported by METP, Malaysian buildings energy uses are reflected by the energy consumption in the industrial and commercial sectors. Most of the buildings' energy consumption is electricity, used for running and operating the plants, lighting, lifts and escalators and other equipment in the buildings. These are amongst the factors that have resulted in the high demand for electricity in Malaysia. As outlined in the eighth Malaysia Plan, Malaysia is taking steps in conserving energy and reducing energy consumption on electricity consumption in building. This paper aims to present the breakdown of the major electricity end uses characteristics of historic buildings in Malaysia. The analysis was performed on annual data, allowing comparison with published benchmarks to give an indication of efficiency. Based on data collected a 'normalisation' calculated electricity consumption was established with the intention of improving the comparison between buildings in different climatic regions or with different occupancy patterns. This is useful for identifying where the design needed further attention and helped pinpoint problem areas within a building. It is anticipated that this study would give a good indication on the electricity consumption characteristics of historic buildings in Malaysia. (Author)

  5. Pulmonary function studies in young healthy Malaysians of Kelantan, Malaysia.

    Bandyopadhyay, Amit

    2011-11-01

    Pulmonary function tests have been evolved as clinical tools in diagnosis, management and follow up of respiratory diseases as it provides objective information about the status of an individual's respiratory system. The present study was aimed to evaluate pulmonary function among the male and female young Kelantanese Malaysians of Kota Bharu, Malaysia, and to compare the data with other populations. A total of 128 (64 males, 64 females) non-smoking healthy young subjects were randomly sampled for the study from the Kelantanese students' population of the University Sains Malaysia, Kota Bharu Campus, Kelantan, Malaysia. The study population (20-25 yr age group) had similar socio-economic background. Each subject filled up the ATS (1978) questionnaire to record their personal demographic data, health status and consent to participate in the study. Subjects with any history of pulmonary diseases were excluded from the study. The pulmonary function measurements exhibited significantly higher values among males than the females. FEV 1% did not show any significant inter-group variation probably because the parameter expresses FEV 1 as a percentage of FVC. FVC and FEV 1 exhibited significant correlations with body height and body mass among males whereas in the females exhibited significant correlation with body mass, body weight and also with age. FEV 1% exhibited significant correlation with body height and body mass among males and with body height in females. FEF 25-75% did not show any significant correlation except with body height among females. However, PEFR exhibited significant positive correlation with all the physical parameters except with age among the females. On the basis of the existence of significant correlation between different physical parameters and pulmonary function variables, simple and multiple regression norms have been computed. From the present investigation it can be concluded that Kelantanese Malaysian youths have normal range of

  6. Plasma total antioxidant capacity (TAC) in obese Malaysian subjects.

    Lim, S H; Fan, S H; Say, Y H

    2012-12-01

    There is a pressing need to better understand the complex biochemical pathways that lead to the pathogenesis of obesity. Increased oxidative stress and decreased antioxidant capacity have been identified to be associated with obesity. Therefore, the objectives of this study were to determine the plasma total antioxidant capacity (TAC) levels of Malaysian subjects and to evaluate its potential association with obesity and related anthropometric measurements. Plasma TAC of 362 multi-ethnic Malaysian subjects from the Kampar Health Clinic (138 males, 224 females; 124 ethnic Malays, 152 Chinese, 86 Indians; 192 non-obese, 170 obese) was measured using Trolox equivalent antioxidant capacity (TEAC) 96-well plate assay. Plasma TAC was significantly lower in obese subjects (M +/- SE = 292 +/- 10.4 micromol/L) compared to non-obese subjects (397 +/- 8.58 micromol/L), whereas it was significantly higher in males and those in the 21-30 age group. Those with salty food preference and practising a strict vegetarian diet also had significantly higher plasma TAC. However, no association was found for other dietary habits (coffee intake) and lifestyle factors (physical activity, smoking). Plasma TAC was also significantly negatively correlated with diastolic blood pressure, waist and hip circumferences, weight, body mass index, total body fat, % subcutaneous fat, visceral fat level, resting metabolism and % skeletal muscle. Plasma TAC was found to be associated with obesity, strict vegetarian practice, salty food preference and all obesity anthropometric indicators, except systolic blood pressure and pulse rate. Obese people have decreased plasma TAC indicating a compromised systemic antioxidant defence and increased oxidative stress.

  7. Refining English Language Tests for University Admission: A Malaysian Example

    Arshad Abd Samad

    2008-06-01

    Full Text Available English has now become the lingua franca of much of technological, business and academic endeavours. Consequently, learning the English language is now seen as vital, especially at the university level where proficiency in the language has become a selection criterion. At present, the Malaysian University English Test (MUET has been adopted by Malaysian public universities as an indicator of English language proficiency. A student’s overall result depends on all the four language components of the MUET and often determines the number and nature of the English language courses he or she has to attend at university. This study seeks to examine whether MUET is an accurate predictor of performance and success at university and how the MUET can be finetuned as an entry level English language test. It was carried out among 52 third year undergraduates of the Faculty of Educational Studies, Universiti Putra Malaysia, Serdang, Malaysia, admitted into the Teaching English as a Second Language (TESL programme. The findings of the study do not offer conclusive evidence about the validity of MUET as a predictor of academic success. However, six models of various combinations of scores on language components on the MUET scores are examined in terms of their effectiveness in increasing the accuracy in selecting students for the TESL programme. The correlations obtained using these models indicate that the combination of various components of the MUET can be used to more accurately predict student achievement at tertiary level than the cumulative MUET score itself. The results of these correlations and their implications in using language tests as admission requirements in general are also discussed

  8. Malaysian Instructors’ Assessment Beliefs in Tertiary ESL Classrooms

    Niveen R. M. Elshawa

    2017-04-01

    Full Text Available Language assessment can be a valuable tool for providing information regarding language teaching. Given the importance of assessment that has undergone much change, there are important issues that warrant investigation, particularly those related to language instructors. Understanding the assessment beliefs of ESL instructors, especially at the tertiary level, is important since it can help improve the quality of assessment practices as well. Therefore, this study investigated English language instructors’ assessment beliefs in the Malaysian context. This study adopted a cross-sectional research design. The survey method was utilized to collect data from six Malaysian universities using a purposive sampling strategy. English language instructors (n=83 were selected via purposive sampling for the study. Findings of the study revealed that English language instructors believed that the purpose of assessment was to improve teaching and learning. Regarding the assessment beliefs that are related to the assessment purposes, analyses of data showed that the items that received the highest percentage of agreement were diagnosing strength and weaknesses in students, providing information about students’ progress and providing feedback to students as they learn, respectively. Although they reported using both formal and informal assessment of their students’ work, English language instructors relied heavily on paper and pencil assessment while giving more weightage on formative assessment. The majority of English language instructors reported employing marking schemes for the courses they taught, carrying out sample marking and providing feedback. Finally, English language instructors reported using different types of assessments for every language skill taught in their language unit/center. The findings highlight the fact that English instructors should be more empowered in their role as the assessors of students. Their knowledge about what, how

  9. Why do young adolescents bully? Experience in Malaysian schools.

    Wan Ismail, Wan Salwina; Nik Jaafar, Nik Ruzyanei; Sidi, Hatta; Midin, Marhani; Shah, Shamsul Azhar

    2014-01-01

    To determine sociodemographic and psychological factors associated with bullying behavior among young adolescents in Malaysia. This is a cross-sectional study of four hundred ten 12-year-old adolescents from seven randomly sampled schools in the Federal Territory of Kuala Lumpur, Malaysia. Sociodemographic features of the adolescents and their parents, bullying behavior (Malaysian Bullying Questionnaire), ADHD symptoms (Conners Rating Scales), and internalizing and externalizing behavior (Child Behaviour Checklist) were obtained from adolescents, parents and teachers, respectively. Only male gender (OR=7.071, p=0.01*, CI=1.642-30.446) was a significant sociodemographic factor among bullies. Predominantly hyperactive (OR=2.285, p=0.00*, CI=1.507-3.467) and inattentive ADHD symptoms reported by teachers (OR=1.829, p=0.03*, CI=1.060-3.154) and parents (OR=1.709, p=0.03*, CI=1.046-2.793) were significant risk factors for bullying behavior while combined symptoms reported by young adolescents (OR=0.729, p=0.01*, CI=0.580-0.915) and teachers (OR=0.643, p=0.02*, CI=0.440-0.938) were protective against bullying behavior despite the influence of conduct behavior (OR=3.160, p=0.00*, CI=1.600-6.241). Internalizing behavior, that is, withdrawn (OR=0.653, p=0.04*, CI=0.436-0.977) and somatic complaints (OR=0.619, p=0.01*, CI=0.430-0.889) significantly protect against bullying behavior. Recognizing factors associated with bullying behavior, in particular factors distinctive to the local population, facilitates in strategizing effective interventions for school bullying among young adolescents in Malaysian schools. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth

    Suam Gonzalez

    2017-06-01

    Full Text Available Cell size is amenable by genetic and environmental factors. The highly conserved nutrient-responsive Target of Rapamycin (TOR signaling pathway regulates cellular metabolic status and growth in response to numerous inputs. Timing and duration of TOR pathway activity is pivotal for both cell mass built up as well as cell cycle progression and is controlled and fine-tuned by the abundance and quality of nutrients, hormonal signals, growth factors, stress, and oxygen. TOR kinases function within two functionally and structurally discrete multiprotein complexes, TORC1 and TORC2, that are implicated in temporal and spatial control of cell size and growth respectively; however, recent data indicate that such functional distinctions are much more complex. Here, we briefly review roles of the two complexes in cellular growth and cytoarchitecture in various experimental model systems.

  11. Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila.

    Wen, Jung-Kun; Wang, Yi-Ting; Chan, Chih-Chiang; Hsieh, Cheng-Wen; Liao, Hsiao-Man; Hung, Chin-Chun; Chen, Guang-Chao

    2017-11-16

    Autophagy is essential for maintaining cellular homeostasis and survival under various stress conditions. Autophagy-related gene 9 (Atg9) encodes a multipass transmembrane protein thought to act as a membrane carrier for forming autophagosomes. However, the molecular regulation and physiological importance of Atg9 in animal development remain largely unclear. Here, we generated Atg9 null mutant flies and found that loss of Atg9 led to shortened lifespan, locomotor defects, and increased susceptibility to stress. Atg9 loss also resulted in aberrant adult midgut morphology with dramatically enlarged enterocytes. Interestingly, inhibiting the TOR signaling pathway rescued the midgut defects of the Atg9 mutants. In addition, Atg9 interacted with PALS1-associated tight junction protein (Patj), which associates with TSC2 to regulate TOR activity. Depletion of Atg9 caused a marked decrease in TSC2 levels. Our findings revealed an antagonistic relationship between Atg9 and TOR signaling in the regulation of cell growth and tissue homeostasis.

  12. The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos.

    Kuhn, Hallie; Sopko, Richelle; Coughlin, Margaret; Perrimon, Norbert; Mitchison, Tim

    2015-11-15

    Yolk provides an important source of nutrients during the early development of oviparous organisms. It is composed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism of yolk is initiated by acidification of the yolk platelet, leading to the activation of Cathepsin-like proteinases, but it is unknown how this process is triggered. Yolk catabolism initiates at cellularization in Drosophila melanogaster embryos. Using maternal shRNA technology we found that yolk catabolism depends on the Tor pathway and on the autophagy-initiating kinase Atg1. Whereas Atg1 was required for a burst of spatially regulated autophagy during late cellularization, autophagy was not required for initiating yolk catabolism. We propose that the conserved Tor metabolic sensing pathway regulates yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome. © 2015. Published by The Company of Biologists Ltd.

  13. mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat

    Peng, Xingang, E-mail: pengxinggang26@sina.com [Department of Emergency General Surgery, The Affiliated Hospital of Qingdao University, Qingdao (China); Zhang, Donghui, E-mail: zhangdonghuiyx@sina.com [Department of Infectious Disease, Linyi People’s Hospital, Linyi (China); Li, Zhengling, E-mail: lizhenglingzz@sina.com [Department of Nursing, Tengzhou Central People’s Hospital, Tengzhou (China); Fu, Meili, E-mail: fumeilidrlinyi@tom.com [Department of Infectious Disease, Linyi People’s Hospital, Linyi (China); Liu, Haiyan, E-mail: liuhaiyanlinyi5@sina.com [Department of Nursing, Linyi People’s Hospital, Linyi (China)

    2016-09-02

    Histone deacetylases (HDACs) hyper-activity in hepatocellular carcinoma (HCC) is often associated with patients’ poor prognosis. Our previous study has shown that resminostat, a novel HDAC inhibitor (HDACi), activated mitochondrial permeability transition pore (mPTP)-dependent apoptosis pathway in HCC cells. Here we explored the potential resminostat resistance factor by focusing on mammalian target of rapamycin (mTOR). We showed that AZD-2014, a novel mTOR kinase inhibitor, potentiated resminostat-induced cytotoxicity and proliferation inhibition in HCC cells. Molecularly, AZD-2014 enhanced resminostat-induced mPTP apoptosis pathway activation in HCC cells. Inhibition of this apoptosis pathway, by the caspase-9 specific inhibitor Ac-LEHD-CHO, the mPTP blockers (sanglifehrin A/cyclosporine A), or by shRNA-mediated knockdown of mPTP component cyclophilin-D (Cyp-D), significantly attenuated resminostat plus AZD-2014-induced cytotoxicity and apoptosis in HCC cells. Significantly, mTOR shRNA knockdown or kinase-dead mutation (Asp-2338-Ala) also sensitized HCC cells to resminostat, causing profound cytotoxicity and apoptosis induction. Together, these results suggest that mTOR could be a primary resistance factor of resminostat. Targeted inhibition of mTOR may thus significantly sensitize HCC cells to resminostat. - Highlights: • AZD-2014 potentiates resminostat’s cytotoxicity against HCC cells. • AZD-2014 facilitates resminostat-induced HCC cell apoptosis. • AZD-2014 augments resminostat-induced mitochondrial apoptosis pathway activation. • mTOR shRNA or kinase-dead mutation significantly sensitizes HCC cells to resminostat.

  14. Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.

    Veiga, Sonia Rosa; Ge, Xuemei; Mercer, Carol A; Hernández-Alvarez, María Isabel; Thomas, Hala Elnakat; Hernández-Losa, Javier; Ramón Y Cajal, Santiago; Zorzano, Antonio; Thomas, George; Kozma, Sara C

    2018-04-24

    Hepatocellular carcinoma (HCC) ranks second in cancer mortality and has limited therapeutic options. We recently described the synergistic effect of allosteric and ATP-site competitive inhibitors against the mammalian target of rapamycin (mTOR) for the treatment of HCC. However, such inhibitors induce glycemia and increase mitochondrial efficiency. Here we determined whether the mitochondrial complex I inhibitor Phenformin could reverse both side effects, impose an energetic-stress on cancer cells and suppress the growth of HCC. Human HCC cell lines were used in vitro to access the signaling and energetic impact of mTOR inhibitors and Phenformin, either alone or in combination. Next, the therapeutic utility of these drugs alone or in combination was investigated pre-clinically in human orthotopic tumors implanted in mice, by analyzing their impact on the tumor burden and overall survival. We found Phenformin caused mitochondrial dysfunction and fragmentation, inducing a compensatory shift to glycolysis. In contrast, dual inhibition of mTOR impaired cell growth and glycolysis, while increasing mitochondrial fusion and efficiency. In a mouse model of human HCC, dual inhibition of mTOR, together with Phenformin, was highly efficacious in controlling tumor burden. However, more striking, pretreatment with Phenformin sensitized tumors to dual inhibition of mTOR, leading to a dramatic improvement in survival. Treatment of HCC cells in vitro with the biguanide Phenformin causes a metabolic shift to glycolysis, mitochondrial dysfunction and fragmentation, and dramatically sensitizes orthotopic liver tumors to dual inhibition of mTOR. We therefore propose this therapeutic approach should be tested clinically in HCC. Copyright ©2018, American Association for Cancer Research.

  15. Rapid molecular evolution across amniotes of the IIS/TOR network.

    McGaugh, Suzanne E; Bronikowski, Anne M; Kuo, Chih-Horng; Reding, Dawn M; Addis, Elizabeth A; Flagel, Lex E; Janzen, Fredric J; Schwartz, Tonia S

    2015-06-02

    The insulin/insulin-like signaling and target of rapamycin (IIS/TOR) network regulates lifespan and reproduction, as well as metabolic diseases, cancer, and aging. Despite its vital role in health, comparative analyses of IIS/TOR have been limited to invertebrates and mammals. We conducted an extensive evolutionary analysis of the IIS/TOR network across 66 amniotes with 18 newly generated transcriptomes from nonavian reptiles and additional available genomes/transcriptomes. We uncovered rapid and extensive molecular evolution between reptiles (including birds) and mammals: (i) the IIS/TOR network, including the critical nodes insulin receptor substrate (IRS) and phosphatidylinositol 3-kinase (PI3K), exhibit divergent evolutionary rates between reptiles and mammals; (ii) compared with a proxy for the rest of the genome, genes of the IIS/TOR extracellular network exhibit exceptionally fast evolutionary rates; and (iii) signatures of positive selection and coevolution of the extracellular network suggest reptile- and mammal-specific interactions between members of the network. In reptiles, positively selected sites cluster on the binding surfaces of insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R), and insulin receptor (INSR); whereas in mammals, positively selected sites clustered on the IGF2 binding surface, suggesting that these hormone-receptor binding affinities are targets of positive selection. Further, contrary to reports that IGF2R binds IGF2 only in marsupial and placental mammals, we found positively selected sites clustered on the hormone binding surface of reptile IGF2R that suggest that IGF2R binds to IGF hormones in diverse taxa and may have evolved in reptiles. These data suggest that key IIS/TOR paralogs have sub- or neofunctionalized between mammals and reptiles and that this network may underlie fundamental life history and physiological differences between these amniote sister clades.

  16. High-throughput mutational analysis of TOR1A in primary dystonia

    Truong Daniel D

    2009-03-01

    Full Text Available Abstract Background Although the c.904_906delGAG mutation in Exon 5 of TOR1A typically manifests as early-onset generalized dystonia, DYT1 dystonia is genetically and clinically heterogeneous. Recently, another Exon 5 mutation (c.863G>A has been associated with early-onset generalized dystonia and some ΔGAG mutation carriers present with late-onset focal dystonia. The aim of this study was to identify TOR1A Exon 5 mutations in a large cohort of subjects with mainly non-generalized primary dystonia. Methods High resolution melting (HRM was used to examine the entire TOR1A Exon 5 coding sequence in 1014 subjects with primary dystonia (422 spasmodic dysphonia, 285 cervical dystonia, 67 blepharospasm, 41 writer's cramp, 16 oromandibular dystonia, 38 other primary focal dystonia, 112 segmental dystonia, 16 multifocal dystonia, and 17 generalized dystonia and 250 controls (150 neurologically normal and 100 with other movement disorders. Diagnostic sensitivity and specificity were evaluated in an additional 8 subjects with known ΔGAG DYT1 dystonia and 88 subjects with ΔGAG-negative dystonia. Results HRM of TOR1A Exon 5 showed high (100% diagnostic sensitivity and specificity. HRM was rapid and economical. HRM reliably differentiated the TOR1A ΔGAG and c.863G>A mutations. Melting curves were normal in 250/250 controls and 1012/1014 subjects with primary dystonia. The two subjects with shifted melting curves were found to harbor the classic ΔGAG deletion: 1 a non-Jewish Caucasian female with childhood-onset multifocal dystonia and 2 an Ashkenazi Jewish female with adolescent-onset spasmodic dysphonia. Conclusion First, HRM is an inexpensive, diagnostically sensitive and specific, high-throughput method for mutation discovery. Second, Exon 5 mutations in TOR1A are rarely associated with non-generalized primary dystonia.

  17. Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes.

    Li, Xiaojuan; Cai, Wenguo; Liu, Yanlin; Li, Hui; Fu, Liwen; Liu, Zengyu; Xu, Lin; Liu, Hongtao; Xu, Tongda; Xiong, Yan

    2017-03-07

    The developmental plasticity of plants relies on the remarkable ability of the meristems to integrate nutrient and energy availability with environmental signals. Meristems in root and shoot apexes share highly similar molecular players but are spatially separated by soil. Whether and how these two meristematic tissues have differential activation requirements for local nutrient, hormone, and environmental cues (e.g., light) remain enigmatic in photosynthetic plants. Here, we report that the activation of root and shoot apexes relies on distinct glucose and light signals. Glucose energy signaling is sufficient to activate target of rapamycin (TOR) kinase in root apexes. In contrast, both the glucose and light signals are required for TOR activation in shoot apexes. Strikingly, exogenously applied auxin is able to replace light to activate TOR in shoot apexes and promote true leaf development. A relatively low concentration of auxin in the shoot and high concentration of auxin in the root might be responsible for this distinctive light requirement in root and shoot apexes, because light is required to promote auxin biosynthesis in the shoot. Furthermore, we reveal that the small GTPase Rho-related protein 2 (ROP2) transduces light-auxin signal to activate TOR by direct interaction, which, in turn, promotes transcription factors E2Fa,b for activating cell cycle genes in shoot apexes. Consistently, constitutively activated ROP2 plants stimulate TOR in the shoot apex and cause true leaf development even without light. Together, our findings establish a pivotal hub role of TOR signaling in integrating different environmental signals to regulate distinct developmental transition and growth in the shoot and root.

  18. Forkhead, a new cross regulator of metabolism and innate immunity downstream of TOR in Drosophila.

    Varma, Disha; Bülow, Margret H; Pesch, Yanina-Yasmin; Loch, Gerrit; Hoch, Michael

    2014-10-01

    Antimicrobial peptides (AMPs) are conserved cationic peptides which act both as defense molecules of the host immune system and as regulators of the commensal microbiome. Expression of AMPs is induced in response to infection by the Toll and Imd pathway. Under non-infected conditions, the transcription factor dFOXO directly regulates a set of AMP expression at low levels when nutrients are limited. Here we have analyzed whether target of rapamycin (TOR), another major regulator of growth and metabolism, also modulates AMP responses in Drosophila. We found that downregulation of TOR by feeding the drug rapamycin or by overexpressing the negative TOR regulators TSC1/TSC2, resulted in a specific induction of the AMPs Diptericin (Dpt) and Metchnikowin (Mtk). In contrast, overexpression of Rheb, which positively regulates TOR led to a repression of the two AMPs. Genetic and pharmacological experiments indicate that Dpt and Mtk activation is controlled by the transcription factor Forkhead (FKH), the founding member of the FoxO family. Shuttling of FKH from the cytoplasm to the nucleus is induced in the fat body and in the posterior midgut in response to TOR downregulation. The FKH-dependent induction of Dpt and Mtk can be triggered in dFOXO null mutants and in immune-compromised Toll and IMD pathway mutants indicating that FKH acts in parallel to these regulators. Together, we have discovered that FKH is the second conserved member of the FoxO family cross-regulating metabolism and innate immunity. dFOXO and FKH, which are activated upon downregulation of insulin or TOR activities, respectively, act in parallel to induce different sets of AMPs, thereby modulating the immune status of metabolic tissues such as the fat body or the gut in response to the oscillating energy status of the organism. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Cross regulation between mTOR signaling and O-GlcNAcylation.

    Very, Ninon; Steenackers, Agata; Dubuquoy, Caroline; Vermuse, Jeanne; Dubuquoy, Laurent; Lefebvre, Tony; El Yazidi-Belkoura, Ikram

    2018-06-01

    The hexosamine biosynthetic pathway (HBP) integrates glucose, amino acids, fatty acids and nucleotides metabolisms for uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) synthesis. UDP-GlcNAc is the nucleotide sugar donor for O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) processes. O-GlcNAc transferase (OGT) is the enzyme which transfers the N-acetylglucosamine (O-GlcNAc) residue onto target proteins. Several studies previously showed that glucose metabolism dysregulations associated with obesity, diabetes or cancer correlated with an increase of OGT expression and global O-GlcNAcylation levels. Moreover, these diseases present an increased activation of the nutrient sensing mammalian target of rapamycin (mTOR) pathway. Other works demonstrate that mTOR regulates protein O-GlcNAcylation in cancer cells through stabilization of OGT. In this context, we studied the cross-talk between these two metabolic sensors in vivo in obese mice predisposed to diabetes and in vitro in normal and colon cancer cells. We report that levels of OGT and O-GlcNAcylation are increased in obese mice colon tissues and colon cancer cells and are associated with a higher activation of mTOR signaling. In parallel, treatments with mTOR regulators modulate OGT and O-GlcNAcylation levels in both normal and colon cancer cells. However, deregulation of O-GlcNAcylation affects mTOR signaling activation only in cancer cells. Thus, a crosstalk exists between O-GlcNAcylation and mTOR signaling in contexts of metabolism dysregulation associated to obesity or cancer.

  20. Hypothalamic roles of mTOR complex I: Integration of nutrient and hormone signals to regulate energy homeostasis

    Mammalian or mechanistic target of rapamycin (mTOR) senses nutrient, energy, and hormone signals to regulate metabolism and energy homeostasis. mTOR activity in the hypothalamus, which is associated with changes in energy status, plays a critical role in the regulation of food intake and body weight...