WorldWideScience

Sample records for machado-joseph disease mjd

  1. Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3): a two-case report

    NARCIS (Netherlands)

    Bettencourt, C.; Santos, C.; Coutinho, P.; Rizzu, P.; Vasconcelos, J.; Kay, T.; Cymbron, T.; Raposo, M.; Heutink, P.; Lima, M.

    2011-01-01

    Background: Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder of late onset, which is caused by a CAG repeat expansion in the coding region of the ATXN3 gene. This disease presents clinical heterogeneity, which cannot be

  2. Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3: a two-case report

    Directory of Open Access Journals (Sweden)

    Vasconcelos João

    2011-10-01

    Full Text Available Abstract Background Machado-Joseph disease (MJD, or spinocerebellar ataxia type 3 (SCA3, is an autosomal dominant neurodegenerative disorder of late onset, which is caused by a CAG repeat expansion in the coding region of the ATXN3 gene. This disease presents clinical heterogeneity, which cannot be completely explained by the size of the repeat tract. MJD presents extrapyramidal motor signs, namely Parkinsonism, more frequently than the other subtypes of autosomal dominant cerebellar ataxias. Although Parkinsonism seems to segregate within MJD families, only a few MJD patients develop parkinsonian features and, therefore, the clinical and genetic aspects of these rare presentations remain poorly investigated. The main goal of this work was to describe two MJD patients displaying the parkinsonian triad (tremor, bradykinesia and rigidity, namely on what concerns genetic variation in Parkinson's disease (PD associated loci (PARK2, LRRK2, PINK1, DJ-1, SNCA, MAPT, APOE, and mtDNA tRNAGln T4336C. Case presentation Patient 1 is a 40 year-old female (onset at 30 years of age, initially with a pure parkinsonian phenotype (similar to the phenotype previously reported for her mother. Patient 2 is a 38 year-old male (onset at 33 years of age, presenting an ataxic phenotype with parkinsonian features (not seen either in other affected siblings or in his father. Both patients presented an expanded ATXN3 allele with 72 CAG repeats. No PD mutations were found in the analyzed loci. However, allelic variants previously associated with PD were observed in DJ-1 and APOE genes, for both patients. Conclusions The present report adds clinical and genetic information on this particular and rare MJD presentation, and raises the hypothesis that DJ-1 and APOE polymorphisms may confer susceptibility to the parkinsonian phenotype in MJD.

  3. Machado-Joseph Disease

    Science.gov (United States)

    ... Caregiver Education » Fact Sheets Machado-Joseph Disease Fact Sheet What is Machado-Joseph disease? What are the ... the repeat is in a protein-producing or coding region of the gene. Modifications of the mutant ...

  4. Machado-Joseph Disease in Pedigrees of Azorean descent is Linked to Chromosome 14

    OpenAIRE

    George-Hyslop, P. St; Rogaeva, E.; Huterer, J.; Tsuda, T.; Santos, J.; Haines, J. L.; Schlumpf, K.; Rogaev, E. I.; Liang, Y.; McLachlan, D. R. Crapper; Kennedy, J.; Weissenbach, J.; Billingsley, G. D.; Cox, D. W.; Lang, A. E.

    1994-01-01

    A locus for Machado-Joseph disease (MJD) has recently been mapped to a 30-cM region of chromosome 14q in five pedigrees of Japanese descent. MJD is a clinically pleomorphic neurodegenerative disease that was originally described in subjects of Azorean descent. In light of the nonallelic heterogeneity in other inherited spinocere-bellar ataxias, we were interested to determine if the MJD phenotype in Japanese and Azorean pedigrees arose from mutations at the same locus. We provide evidence tha...

  5. The SCA1 (Spinocerebellar ataxia type 1 and MJD (Machado-Joseph disease CAG repeats in normal individuals: segregation analysis and allele frequencies

    Directory of Open Access Journals (Sweden)

    Cláudia Emília Vieira Wiezel

    2003-01-01

    Full Text Available Spinocerebellar ataxia type 1 (SCA1 and Machado-Joseph disease (MJD/SCA3 are autosomal dominant neurodegenerative diseases caused by expansions of a CAG trinucleotide repeat in the SCA1 and MJD genes. These expanded sequences are unstable upon transmission, leading to an intergeneration increase in the number of repeats (dynamic mutation. The transmission of the CAG repeat was studied in normal mother-father-child trios, referred for paternity testing (SCA1, n = 367; MJD, n = 879. No segregation distortion was detected. The CAG allele frequencies were determined in 330 unrelated individuals (fathers from couples tested for paternity. The allele frequency distributions did not differ from those previously reported for European populations. The estimated values for the statistic parameters indicating diversity at the SCA1 locus did not differ much from those reported previously for other STRs in the Brazilian population, while those for the MJD locus were close to or higher than the maximum values of previous reports. This shows that SCA1 and MJD are highly informative loci for applications in genetic and population studies and for forensic analysis.

  6. Iodine-123-labeled meta-iodobenzylguanidine myocardial scintigraphy evaluation of Machado-Joseph disease

    International Nuclear Information System (INIS)

    Kazuta, Toshinari; Hayashi, Michiyuki; Yoshita, Mitsuhiro; Hirai, Shunsaku

    1998-01-01

    Iodine-123-labeled meta-iodobenzylguanidine (( 123 I)MIBG), an analogue of guanetidine, is used as a tracer for evaluation of the function of sympathetic neurons. To investigate cardiac sympathetic function in Machado-Joseph disease (MJD), ( 123 I)MIBG myocardial scintigraphy was performed in 12 patients with MJD and 20 controls. In planar imaging studies, the heart to the mediastinum of the average count ratio (H/M) was calculated for both early and delayed images. The mean values of H/M in delayed images of MJD was lower than those of controls (p 123 I)MIBG myocardial scintigraphy in MJD can be seen earlier than abnormal sudomotor system detected by SSR. (author)

  7. Machado-Joseph disease versus hereditary spastic paraplegia: case report Doença de Machado-Joseph versus paraplegia espástica hereditária: relato de caso

    Directory of Open Access Journals (Sweden)

    Hélio A. Ghizoni Teive

    2001-09-01

    Full Text Available Machado-Joseph disease (MJD is the most common autosomal dominant spinocerebellar ataxia and presents great phenotypic variability. MJD presenting with spastic paraparesis was recently described in Japanese patients. We report the case of 41-year-old woman with the phenotype of complicated hereditary spastic paraplegia. Her father died at the age of 56 years due to an undiagnosed progressive neurological disease that presented parkinsonism. She had an expanded allele with 66 CAG repeats and a normal allele with 22 repeats in the gene of MJD. MJD should be considered in the differential diagnosis of autosomal dominant complicated HSP. A patient with the phenotype of complicated HSP and relatives with other clinical features of a neurodegenerative disease should raise the suspicion of MJD.A doença de Machado-Joseph (DMJ é a ataxia espinocerebelar autossômica dominante mais prevalente e apresenta grande variabilidade fenotípica. DMJ apresentando-se com o fenótipo de paraparesia espástica foi recentemente descrita em pacientes japoneses. Relatamos o caso de uma paciente com fenótipo de paraplegia espástica hereditária (PEH "complicada". Seu pai faleceu com 56 anos de uma doença neurológica progressiva que cursava com parkinsonismo. Estudo genético pela técnica de reação em cadeia da polimerase mostrou um alelo de tamanho normal com 22 repetições e um alelo de tamanho expandido com 66 repetições para o tripleto CAG no gene da DMJ. A DMJ deve ser considerada no diagnóstico diferencial das PEH complicadas autossômicas dominantes. Em um paciente com quadro de PEH e outros familiares com fenótipos diferentes de doenças degenerativas deve-se suspeitar de DMJ.

  8. Machado-Joseph disease in pedigrees of Azorean descent is linked to chromosome 14.

    Science.gov (United States)

    St George-Hyslop, P; Rogaeva, E; Huterer, J; Tsuda, T; Santos, J; Haines, J L; Schlumpf, K; Rogaev, E I; Liang, Y; McLachlan, D R

    1994-07-01

    A locus for Machado-Joseph disease (MJD) has recently been mapped to a 30-cM region of chromosome 14q in five pedigrees of Japanese descent. MJD is a clinically pleomorphic neurodegenerative disease that was originally described in subjects of Azorean descent. In light of the nonallelic heterogeneity in other inherited spinocerebellar ataxias, we were interested to determine if the MJD phenotype in Japanese and Azorean pedigrees arose from mutations at the same locus. We provide evidence that MJD in five pedigrees of Azorean descent is also linked to chromosome 14q in an 18-cM region between the markers D14S67 and AACT (multipoint lod score +7.00 near D14S81). We also report molecular evidence for homozygosity at the MJD locus in an MJD-affected subject with severe, early-onset symptoms. These observations confirm the initial report of linkage of MJD to chromosome 14; suggest that MJD in Japanese and Azorean subjects may represent allelic or identical mutations at the same locus; and provide one possible explanation (MJD gene dosage) for the observed phenotypic heterogeneity in this disease.

  9. A comparative study of blood flow in the cerebellum and brainstem between Machado-Joseph disease and olivopontocerebellar atrophy

    International Nuclear Information System (INIS)

    Fukumitsu, Nobuyoshi; Suzuki, Masahiko; Ito Yasuhiko; Iguchi, Yasuyuki; Mori, Yutaka

    2002-01-01

    In recent years, the neurogenic and pathological differences between Machado-Joseph disease (MJD) and sporadic olivopontocerebellar atrophy (OPCA) have been clarified. We performed N-isopropyl-p-[I-123] iodoamphetamine (IMP) SPECT on 9 patients with MJD and 12 patients with OPCA. The blood flow of the cerebellum in the MJD group was significantly decreased than that of the control group (p<0.0001). That of OPCA group was significantly decreased than those of the control and MJD groups (p<0.0001, respectively). The blood flow of the brainstem in the MJD group was significantly decreased than that of the control group (p<0.001). That of OPCA group was significantly decreased than those of the control and MJD groups (p<0.0001, respectively). The blood flow of cerebellum and brainstem in the OPCA group were much decreased than those of MJD group. IMP distribution pattern in MJD patients obviously differed from that of OPCA patients. (author)

  10. Disartria e doença de Machado-Joseph: relato de caso Dysarthria in Machado-Joseph disease: case report

    Directory of Open Access Journals (Sweden)

    Angela Ruviaro Busanello

    2007-09-01

    Full Text Available O objetivo deste estudo foi descrever os principais aspectos fonoaudiológicos relacionados à fala na doença de Machado-Joseph, em um indivíduo do sexo masculino, selecionado entre outros pacientes portadores desta doença com limitações significativas de fala. O paciente foi atendido no Setor de Fonoaudiologia do Serviço de Fisiatria do Hospital de Clínicas de Porto Alegre. Especificamente quanto à fala e seus processos, observou-se quadro disártrico predominantemente atáxico, que piorou com a evolução da doença, passando de leve para severo. Estes resultados permitiram a conclusão de que as alterações tornam-se significativas na fala do portador de doença de Machado-Joseph, associadas ao comprometimento da respiração, articulação, fonação e ressonância. Concluiu-se também quanto à importância do tratamento fonoaudiológico na doença de Machado-Joseph, sugerindo-se novos estudos, com número maior de indivíduos, sejam realizados, a fim de melhor caracterizar as alterações de fala observadas neste estudo.The aim of this study was to describe the essential speech aspects of Machado-Joseph disease in a male patient with this diagnosis, selected among others with the same disease that received treatment at the Speech-Language Pathology and Audiology department of Hospital de Clínicas de Porto Alegre (Brazil. Regarding the speech process, it was observed ataxic dysarthria, which worsened from light to severe with the evolution of the disease. These results allowed the conclusion that speech alterations become more and more significant for Machado-Joseph patients, together with deficits in breathing, articulation, phonation and resonance. Finally, it was possible to suggest that Speech Pathology treatment is essential in Machado-Joseph disease, although more studies are necessary, with larger samples, in order to better characterize the speech alterations observed this study.

  11. Clinical evaluation of oropharyngeal dysphagia in Machado-Joseph disease

    Directory of Open Access Journals (Sweden)

    Sabrina Mello Alves Corrêa

    2010-12-01

    Full Text Available CONTEXT: In Machado-Joseph disease, poor posture, dystonia and peripheral neuropathy are extremely predisposing to oropharyngeal dysphagia, which is more commonly associated with muscular dystrophy. OBJECTIVE: To evaluate the clinical characteristics of oropharyngeal dysphagia in Machado-Joseph disease patients. METHOD: Forty individuals participated in this study, including 20 with no clinical complaints and 20 dysphagic patients with Machado-Joseph disease of clinical type 1, who were all similar in terms of gender distribution, average age, and cognitive function. The medical history of each patient was reviewed and each subject underwent a clinical evaluation of deglutition. At the end, the profile of dysphagia in patients with Machado-Joseph disease was classified according to the Severity Scale of Dysphagia, as described by O'Neil and collaborators. RESULTS: Comparison between dysphagic patients and controls did not reveal many significant differences with respect to the clinical evaluation of the oral phase of deglutition, since afflicted patients only demonstrated deficits related to the protrusion, retraction and tonus of the tongue. However, several significant differences were observed with respect to the pharyngeal phase. Dysphagic patients presented pharyngeal stasis during deglutition of liquids and solids, accompanied by coughing and/or choking as well as penetration and/or aspiration; these signs were absent in the controls. CONCLUSIONS: Oropharyngeal dysphagia is part of the Machado-Joseph disease since the first neurological manifestations. There is greater involvement of the pharyngeal phase, in relation to oral phase of the deglutition. The dysphagia of these patients is classified between mild and moderate.

  12. Accumulation of Mitochondrial DNA Common Deletion Since The Preataxic Stage of Machado-Joseph Disease.

    Science.gov (United States)

    Raposo, Mafalda; Ramos, Amanda; Santos, Cristina; Kazachkova, Nadiya; Teixeira, Balbina; Bettencourt, Conceição; Lima, Manuela

    2018-04-21

    Molecular alterations reflecting pathophysiologic changes thought to occur many years before the clinical onset of Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3), a late-onset polyglutamine disorder, remain unidentified. The absence of molecular biomarkers hampers clinical trials, which lack sensitive measures of disease progression, preventing the identification of events occurring prior to clinical onset. Our aim was to analyse the mtDNA content and the amount of the common deletion (m.8482_13460del4977) in a cohort of 16 preataxic MJD mutation carriers, 85 MJD patients and 101 apparently healthy age-matched controls. Relative expression levels of RPPH1, MT-ND1 and MT-ND4 genes were assessed by quantitative real-time PCR. The mtDNA content was calculated as the difference between the expression levels of a mitochondrial gene (MT-ND1) and a nuclear gene (RPPH1); the amount of mtDNA common deletion was calculated as the difference between expression levels of a deleted (MT-ND4) and an undeleted (MT-ND1) mitochondrial genes. mtDNA content in MJD carriers was similar to that of healthy age-matched controls, whereas the percentage of the common deletion was significantly increased in MJD subjects, and more pronounced in the preclinical stage (p < 0.05). The BCL2/BAX ratio was decreased in preataxic carriers compared to controls, suggesting that the mitochondrial-mediated apoptotic pathway is altered in MJD. Our findings demonstrate for the first time that accumulation of common deletion starts in the preclinical stage. Such early alterations provide support to the current understanding that any therapeutic intervention in MJD should start before the overt clinical phenotype.

  13. (123I)-IMP SPECT findings in Machado-Joseph disease

    International Nuclear Information System (INIS)

    Suzuki, Masahiko

    1997-01-01

    Single photon emission computed tomography (SPECT) with N-isopropyl-p-( 123 I)iodoamphetamine (IMP) was used to study the dynamics of cerebellar and brainstem metabolic function in patients with Mochado-Joseph disease (MJD), the diagnosis of which was confirmed with genetic analysis. The SPECT data obtained was analyzed semiquantitatively. In patients with MJD, ( 123 I)-IMP accumulation in the cerebellum and brainstem was decreased, and the degree of decrease reflected the clinical severity of MJD. When MJD was mild, the decrease in ( 123 I)-IMP accumulation was much greater in the brainstem than in the cerebellum. However, the decrease in ( 123 I)-IMP accumulation in the cerebellum and brainstem was not correlated with the severity of atrophy or with the number of CAG repeats. ( 123 I)-IMP SPECT was useful for evaluating the decrease in cerebellum and brainstem function in patients with MJD. Results of this study suggest that the functional decrease in MJD may begin in the brainstem. (author)

  14. Double-blind crossover trial of trimethoprim-sulfamethoxazole in spinocerebellar ataxia type 3/Machado-Joseph disease.

    Science.gov (United States)

    Schulte, T; Mattern, R; Berger, K; Szymanski, S; Klotz, P; Kraus, P H; Przuntek, H; Schöls, L

    2001-09-01

    To evaluate the efficiency of a combination of trimethoprim and sulfamethoxazole in patients with spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). Placebo-controlled, double-blind crossover trial in 22 patients with genetically confirmed SCA3/MJD. Study phases of 6 months were separated by a washout period of 4 weeks. Dosages were a combination of trimethoprim, 160 mg, and sulfamethoxazole, 800 mg, twice daily for 2 weeks, followed by a combination of trimethoprim, 80 mg, and sulfamethoxazole, 400 mg, twice daily for 5.5 months. Outpatient department of the Neurological Clinic, Ruhr-University, Bochum, Germany. Ataxia ranking scale, self-assessment score, static posturography, and results of motor performance testing. Effects on the visual system were studied using the achromatic Vision Contrast Test System and the Farnsworth-Munsell 100-hue test for color discrimination. Physical and mental health were documented using the Medical Outcomes Study 36-Item Short-Form Health Survey. Subgroup analyses assessed the influence of age, sex, age at onset, duration of the disease, phenotype, and CAG repeat length on test performance. Twenty of 22 patients completed the study. Dropouts were due to a rash (placebo phase) and an attempted suicide in a family conflict. Trimethoprim-sulfamethoxazole therapy had no significant effect in SCA3/MJD patients in the short-term analysis (2 weeks) or in the long-term interval (6 months). In contrast to previous reports that studied smaller groups of patients, treatment with trimethoprim-sulfamethoxazole did not improve the diverse and complex movement disorders caused by SCA3/MJD. Trimethoprim-sulfamethoxazole had no effect on the visual system and cannot be recommended as a continuous treatment for SCA3/MJD patients.

  15. Cervical and ocular vestibular evoked potentials in Machado-Joseph disease: Functional involvement of otolith pathways.

    Science.gov (United States)

    Ribeiro, Rodrigo Souza; Pereira, Melissa Marques; Pedroso, José Luiz; Braga-Neto, Pedro; Barsottini, Orlando Graziani Povoas; Manzano, Gilberto Mastrocola

    2015-11-15

    Machado-Joseph disease is defined as an autosomal dominant ataxic disorder caused by degeneration of the cerebellum and its connections and is associated with a broad range of clinical symptoms. The involvement of the vestibular system is responsible for several symptoms and signs observed in the individuals affected by the disease. We measured cervical and ocular vestibular evoked myogenic potentials in a sample of Machado-Joseph disease patients in order to assess functional pathways involved. Bilateral measures of cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP) were obtained from 14 symptomatic patients with genetically proven Machado-Joseph disease and compared with those from a control group of 20 healthy subjects. Thirteen (93%) patients showed at least one abnormal test result; oVEMP and cVEMP responses were absent in 17/28 (61%) and 11/28 (39%) measures, respectively; and prolonged latency of cVEMP was found in 3/28 (11%) measures. Of the 13 patients with abnormal responses, 9/13 (69%) patients showed discordant abnormal responses: four with absent oVEMP and present cVEMP, two with absent cVEMP and present oVEMP, and three showed unilateral prolonged cVEMP latencies. Both otolith-related vestibulocollic and vestibulo-ocular pathways are severely affected in Machado-Joseph disease patients evaluated by VEMPs. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease

    Directory of Open Access Journals (Sweden)

    C.M. Lopes-Ramos

    Full Text Available Machado-Joseph disease (MJD or spinocerebellar ataxia type 3 (SCA3 is an autosomal dominant neurodegenerative disorder caused by expansion of the polyglutamine domain of the ataxin-3 (ATX3 protein. MJD/SCA3 is the most frequent autosomal dominant ataxia in many countries. The mechanism underlying MJD/SCA3 is thought to be mainly related to protein misfolding and aggregation leading to neuronal dysfunction followed by cell death. Currently, there are no effective treatments for patients with MJD/SCA3. Here, we report on the potential use of lithium carbonate and coenzyme Q10 to reduce cell death caused by the expanded ATX3 in cell culture. Cell viability and apoptosis were evaluated by MTT assay and by flow cytometry after staining with annexin V-FITC/propidium iodide. Treatment with lithium carbonate and coenzyme Q10 led to a significant increase in viability of cells expressing expanded ATX3 (Q84. In addition, we found that the increase in cell viability resulted from a significant reduction in the proportion of apoptotic cells. Furthermore, there was a significant change in the expanded ATX3 monomer/aggregate ratio after lithium carbonate and coenzyme Q10 treatment, with an increase in the monomer fraction and decrease in aggregates. The safety and tolerance of both drugs are well established; thus, our results indicate that lithium carbonate and coenzyme Q10 are good candidates for further in vivo therapeutic trials.

  17. Paula Coutinho's outstanding contribution to the definition of Machado-Joseph disease.

    Science.gov (United States)

    Garcia, Bruno Carniatto Marques; Germiniani, Francisco Manoel Branco; Marques, Paula; Sequeiros, Jorge; Teive, Hélio Afonso Ghizoni

    2017-10-01

    Machado-Joseph disease, also known as spinocerebellar ataxia type 3, is the most common form of autosomal dominant ataxia in the world. Paula Coutinho, a highly-regarded Portuguese neurologist worldwide, had a seminal participation in the definition of this disease, more than 40 years ago.

  18. Psychological well-being and family satisfaction levels five years after being confirmed as a carrier of the Machado-Joseph disease mutation.

    Science.gov (United States)

    Gonzalez, Carlos; Gomes, Elisabete; Kazachkova, Nadiya; Bettencourt, Conceição; Raposo, Mafalda; Kay, Teresa Taylor; MacLeod, Patrick; Vasconcelos, João; Lima, Manuela

    2012-12-01

    The present study on long-term outcome of presymptomatic testing for Machado-Joseph disease (MJD) aimed to evaluate the psychological well-being and the familial satisfaction of subjects that 5 years prior received an unfavorable result in the predictive testing (PT). The study included 47 testees of Azorean origin (23 from the island of Flores and 24 from S. Miguel) that completed the fourth evaluation session of the MJD protocol, and undertook a neurological examination at the moment of participation in the study. Nearly 50% of testees were symptomatic at the time of the study. Psychological well-being of the 47 participants was evaluated using the Psychological General Well-Being Index (PGWB). The family satisfaction scale by adjectives was applied to obtain information on family dynamics. The average PGWB score of the total participants was of 73.3, a value indicative of psychological well-being. Nearly half of the testees presented scores indicating psychological well-being, whereas scores indicating moderate (28.9%) or severe (23.7%) stress were found in the remaining. The average score in the PGWB scale was lower in symptomatic than in asymptomatic subjects; moreover, the distinct distribution of the well-being categories seen in the two groups shows an impact of the appearance of first symptoms on the psychological state. Motives for undertaking the test, provided 5 years prior, failed to show an impact in well-being. The average score for familial satisfaction was of 134, a value compatible with high familial satisfaction, which represented the most frequent category (59.6%). Results demonstrate that well-being and family satisfaction need to be monitored in confirmed carriers of the MJD mutation. The inclusion of acceptance studies, after PT, as well as the development of acceptance training actions, should be of major importance to anticipate the possibility of psychological damage.

  19. Spinocerebellar ataxia type 3 (Machado-Joseph disease) : severe destruction of the lateral reticular nucleus

    NARCIS (Netherlands)

    Rub, U; de Vos, RAI; Schultz, C; Brunt, ER; Paulson, H; Braak, H

    The lateral reticular nucleus (LRT) of the medulla oblongata is a precerebellar nucleus involved in proprioception and somatomotor automatisms. We investigated this nucleus in five individuals with clinically diagnosed and genetically confirmed spinocerebellar ataxia type 3 (SCA3, Machado-Joseph

  20. [Advances in Neurological Therapeutics for Friedreich Ataxia and Machado-Joseph Disease].

    Science.gov (United States)

    Yabe, Ichiro; Sasaki, Hidenao

    2017-08-01

    We reviewed advances in therapeutics for both Friedreich ataxia and Machado-Joseph disease. Various clinical trials have been carried out, mainly for Friedreich ataxia; however, the therapeutic reports from these trials have not provided much evidence for success. Some interesting clinical trials have been reported, and further developments are expected. Regenerative therapy using umbilical cord mesenchymal stem cells and a therapeutic study investigating a new pathomechanism in animal and/or cell culture studies were reported. We expect that these results will translate to therapeutic strategies for patients with these disorders. In addition, biomarkers play an important role when novel treatments are discovered and clinical trials are performed: hence at present, a number of biomarkers such as gait analysis by triaxial accelerometers and prism adaptation of hand-reaching movements, are being examined.

  1. Analysis of regional cerebral blood flow and distribution volume in Machado-Joseph disease by iodine-{sup 123}I IMP single photon emission computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, Tsunemi; Nakajima, Takashi; Fukuhara, Nobuyoshi [National Saigata Hospital, Ohagata, Niigata (Japan)

    2001-09-01

    Machado-Joseph disease (MJD) is an autosomal dominant spinocerebellar ataxia. Its clinical features vary greatly in different generations of the same family. Regional cerebral blood flow (rCBF) and distribution volume (V{sub d}) in the pons, cerebellum, and cerebral cortex were measured in 12 patients with MJD by autoradiography (ARG) and the table look-up (TLU) method of iodine-123 IMP ({sup 123}I-IMP) single photon emission computed tomography (SPECT). Representative cases were as follows: A 46-year-old woman first experienced gait ataxia at age 38. Computed tomography (CT) and magnetic resonance imaging (MRI) showed no atrophy in the pons or cerebellum, but rCBF measured by the {sup 123}I-IMP SPECT ARG method detected hypoperfusion in the pons, and cerebellar vermis and hemisphere. A 76-year-old woman first experienced gait ataxia at age 69. CT and MRI findings showed severe atrophy in the pons, and cerebellar vermis and hemisphere. Moreover, rCBF was decreased in the pons, whereas it was not decreased in the cerebellar vermis and hemisphere. In the pons of patients with MJD, rCBF was markedly decreased regardless of disease severity. Because this SPECT finding for the pons looked like a 'dot', we have called it the 'pontine dot sign'. In the MJD group, rCBF was significantly decreased in the pons (Student's t test, p<0.01) and cerebellar vermis (p<0.05). The V{sub d} was also significantly decreased in the pons (p<0.005) in comparison with that for normal subjects. Pearson's correlation analysis yielded a significant relationship between the rCBF in the pons and age at onset (r=0.578, p<0.05). There was a strong correlation between the V{sub d} for the pons and age at onset (r=0.59, p<0.05). Person's correlation analysis also showed a significant relationship between the V{sub d} in the cerebellar hemispheres and International Cooperative Ataxia Rating Scale (r=0.644, p<0.05). The pontine rCBFs in patients with early onset MJD

  2. Frequency of the different mutations causing spinocerebellar ataxia (SCA1, SCA2, MJD/SCA3 and DRPLA in a large group of Brazilian patients Freqüência das mutações que causam ataxia espinocerebelar (SCA1, SCA2, MJD/SCA3 e DRPLA em um grupo numeroso de pacientes Brasileiros

    Directory of Open Access Journals (Sweden)

    Iscia Lopes-Cendesi

    1997-09-01

    Full Text Available Spinocerebellar ataxia type 1 (SCA1, spinocerebellar ataxia type 2 (SCA2 and Machado-Joseph disease or spinocerebellar ataxia type 3 (MJD/SCA3 are three distinctive forms of autosomal dominant spinocerebellar ataxia (SCA caused by expansions of an unstable CAG repeat localized in the coding region of the causative genes. Another related disease, dentatorubropallidoluysian atrophy (DRPLA is also caused by an unstable triplet repeat and can present as SCA in late onset patients. We investigated the frequency of the SCA1, SCA2, MJD/SCA3 and DRPLA mutations in 328 Brazilian patients with SCA, belonging to 90 unrelated families with various patterns of inheritance and originating in different geographic regions of Brazil. We found mutations in 35 families (39%, 32 of them with a clear autosomal dominant inheritance. The frequency of the SCA1 mutation was 3% of all patients; and 6 % in the dominantly inherited SCAs. We identified the SCA2 mutation in 6% of all families and in 9% of the families with autosomal dominant inheritance. The MJD/SCA3 mutation was detected in 30 % of all patients; and in the 44% of the dominantly inherited cases. We found no DRPLA mutation. In addition, we observed variability in the frequency of the different mutations according to geographic origin of the patients, which is probably related to the distinct colonization of different parts of Brazil. These results suggest that SCA may be occasionally caused by the SCA1 and SCA2 mutations in the Brazilian population, and that the MJD/SCA3 mutation is the most common cause of dominantly inherited SCA in Brazil.Ataxia espinocerebelar tipo 1 (SCA1, ataxia espinocerebelar tipo 2 (SCA2 e doença de Machado-Joseph ou ataxia espinocerebelar tipo 3 (MJD/SCA3 são três formas de ataxia espinocerebelar (SCA que apresentam herança genética autossômica dominante. Nessas três doenças foi encontrada uma expansão instável de trinucleotídeo CAG localizada na região codificadora dos

  3. A família Drew de Walworth: um século após a avaliação inicial finalmente o diagnóstico doença de Machado-Joseph The Drew family of Walworth: one century from the first evaluation until the final diagnosis, Machado-Joseph disease

    Directory of Open Access Journals (Sweden)

    Hélio A. Ghizoni Teive

    2004-03-01

    Full Text Available As enfermidades heredo-degenerativas, entre elas as ataxias cerebelares autossômicas dominantes, agora conhecidas como ataxias espinocerebelares (AEC, correspondem a extenso grupo de s com grande heterogeneidade genética. Algumas formas de AEC, em especial a de Machado-Joseph (DMJ, caracteriza-se por acentuada variabilidade de expressão fenotípica intra e inter-familial. Em 1895, na Grã-Bretanha, foi descrita uma família com uma forma autossômica dominante de AEC que viria a ser conhecida como a família Drew de Walworth. Desde sua descrição inicial até 1995, quando do diagnóstico genético final de DMJ, vários membros e gerações desta família foram examinados e seus achados descritos na literatura por famosos neurologistas como Gowers, Stewart, Collier, Kinnier-Wilson, Turner, Worster-Drought, Ferguson, Critchley e Anita Harding. Neste artigo, os autores descrevem a trajetória histórica tortuosa e as discussões sobre os diagnósticos nosológicos propostos no decorrer de um século, com o propósito de mostrar a impressionante e atraente complexidade que envolve este grupo de s neurodegenerativas.Autosomal dominant spinocerebellar ataxia (SCA is an heterogeneous group of neurodegenerative diseases involving cerebellum and its connections. Several forms have already been described, and it seems the most common form of SCA observed among the many series of families described worldwide is SCA3 (Machado-Joseph disease. SCA3 is characterized by a marked phenotypic expression with a wide spectrum of clinical findings including cerebellar ataxia, pyramidal and extrapyramidal (e.g. dystonia, parkinsonism, lower motor neuron syndrome and peripheral neuropathy. The Drew family of Walworth, England, has several affected members seen and described by famous neurologists including Gowers, Stewart, Collier, Kinnier-Wilson, Turner, Worster-Drought, Ferguson, Critchley, and Anita Harding from 1895 to our days. In fact, the final genetic

  4. Regional cerebral blood flow measured with N-isopropyl-p-[123I]iodoamphetamine single-photon emission tomography in patients with Joseph disease

    International Nuclear Information System (INIS)

    Takahashi, Naoya; Odano, Ikuo; Nishihara, Mamiko; Yuasa, Tatsuhiko; Sakai, Kunio

    1994-01-01

    Regional cerebral blood flow (rCBF) was measured in five Japanese patients who were clinically diagnosed as having Joseph disease, also called Machado-Joseph disease or Azorean disease, using N-isopropyl-p-[ 123 I]iodoamphetamine (IMP) and single-photon emission tomography (SPET). Cerebellar atrophy was evaluated by a five-step rating scale as defined on X-ray computed tomography (X-CT). Compared with ten age-matched normal controls (mean cerebellar CBF ± SD: 66.9 ± 6.6 ml/100 g/min), rCBF in patients with Joseph disease was significantly decreased in the cerebellum (mean ± SD: 50.2 ± 7.3 ml/100 g/min). No significant relationship, however, was found between the decrease in rCBF in the cerebellum and the degree of cerebellar atrophy on X-CT. rCBF in the cerebellum was minimally decreased in one patient who had severe cerebellar atrophy and in two patients with moderate atrophy. These data may support the findings that Purkinje cells in the cerebellum are almost normal in Joseph disease, and that the granular and molecular layers remain intact in spite of cortical atrophy of the cerebellum. It is concluded that [ 123 I]-IMP SPET is able to identify pathological and metabolic changes in the cerebellum that do not appear on X-CT or magnetic resonance imaging, and thus is useful for the diagnosis of Joseph disease. (orig.)

  5. Machado-Joseph Disease

    Science.gov (United States)

    ... blurred vision, loss of the ability to distinguish color and/or contrast, and inability to control ... parkinsonian features, levodopa therapy can help for many years. Treatment with antispasmodic ...

  6. Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.

    Directory of Open Access Journals (Sweden)

    Mimi Cushman-Nick

    Full Text Available There are no effective therapeutics that antagonize or reverse the protein-misfolding events underpinning polyglutamine (PolyQ disorders, including Spinocerebellar Ataxia Type-3 (SCA3. Here, we augment the proteostasis network of Drosophila SCA3 models with Hsp104, a powerful protein disaggregase from yeast, which is bafflingly absent from metazoa. Hsp104 suppressed eye degeneration caused by a C-terminal ataxin-3 (MJD fragment containing the pathogenic expanded PolyQ tract, but unexpectedly enhanced aggregation and toxicity of full-length pathogenic MJD. Hsp104 suppressed toxicity of MJD variants lacking a portion of the N-terminal deubiquitylase domain and full-length MJD variants unable to engage polyubiquitin, indicating that MJD-ubiquitin interactions hinder protective Hsp104 modalities. Importantly, in staging experiments, Hsp104 suppressed toxicity of a C-terminal MJD fragment when expressed after the onset of PolyQ-induced degeneration, whereas Hsp70 was ineffective. Thus, we establish the first disaggregase or chaperone treatment administered after the onset of pathogenic protein-induced degeneration that mitigates disease progression.

  7. Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.

    Science.gov (United States)

    Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Conceição, Mariana; Déglon, Nicole; de Almeida, Luís Pereira

    2013-08-01

    Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is a fatal, dominant neurodegenerative disorder caused by the polyglutamine-expanded protein ataxin-3. Clinical manifestations include cerebellar ataxia and pyramidal signs culminating in severe neuronal degeneration. Currently, there is no therapy able to modify disease progression. In the present study, we aimed at investigating one of the most severely affected brain regions in the disorder--the cerebellum--and the behavioral defects associated with the neuropathology in this region. For this purpose, we injected lentiviral vectors encoding full-length human mutant ataxin-3 in the mouse cerebellum of 3-week-old C57/BL6 mice. We show that circumscribed expression of human mutant ataxin-3 in the cerebellum mediates within a short time frame--6 weeks, the development of a behavioral phenotype including reduced motor coordination, wide-based ataxic gait, and hyperactivity. Furthermore, the expression of mutant ataxin-3 resulted in the accumulation of intranuclear inclusions, neuropathological abnormalities, and neuronal death. These data show that lentiviral-based expression of mutant ataxin-3 in the mouse cerebellum induces localized neuropathology, which is sufficient to generate a behavioral ataxic phenotype. Moreover, this approach provides a physiologically relevant, cost-effective and time-effective animal model to gain further insights into the pathogenesis of MJD and for the evaluation of experimental therapeutics of MJD.

  8. Machado-Joseph disease op azorean ancestry in Brazil: the Catarina kindred neurological, neuroimaging, psychiatric and neuropsychological findings in the largest known family, the «Catarina» kindred

    Directory of Open Access Journals (Sweden)

    J. Radvany

    1993-03-01

    Full Text Available At the moment 9 seemingly independent families with the clinical diagnosis of MJD are known in Brazil. The largest family tree of Azorean ancestry contatins 622 individuals in 9 generations. 236 were examined, 39 found to be affected by two examiners. Pheno-types I, II and III were expressed by 12, 23 and 4 patients with age of onset by phenotypea being 10-48, 14-54 and 30-55 respectively. Although clinically more severe, juvenile onset type I disease did not show as severe a ponto-mesencephialic atrophy on MRI as the father with type II disease of similar symptomatic duration. None of the 8 patients examined with MRI showed olivary atrophy or pallidal abnormalities. 12 affected and 23 at risk were evaluated with neuropsychological tests. Attention was normal in both groups. Verbal memory scores were below normal in the affected and there was greater decay with time than in the risk group. Both scored below normal in identifying silluettes and constructional praxis. Visual memory scores were well below normal for both, with many rotations but no omissions or confabulations. A peculiar pattern of multiplying internal details called «the fly-eye effect» was observed in 6 affected and 8 at risk. Defective color distinction when multiple colors presented close to each other, in face of proper naming of individual colors («color simultantagnosia», was looked for in 29 people. 4/10 affected and 4/19 at risk showed this phenomenon. Cognitive dysfunctions in this MJD family are prominent in the sphere of vision. Whether they constitute an early manifestation in those at risk and thus serve as a clinical identifier of the illnes is yet to be established. Depression was looked for in the history of the family with DSM III-R criteria and an atempt at quantification with the Montgomery-Asberg Rating Scale. There was no significant quantitative difference between affected and at risk. Once undeniably symptomatic however, the patients had no, or less

  9. "The raven", by Machado de Assis "The raven", by Machado de Assis

    Directory of Open Access Journals (Sweden)

    Sérgio Luiz Prado Bellei

    2008-04-01

    Full Text Available The Brazilian critic José Guilherme Merquior once claimed that Machado de Assis's translation of "The Raven" should not be considered inferior to the well known translation of the Portuguese poet Fernando Pessoa. 1 Unfortunately Merquior does not seem to find necessary to give reasons for this evaluation. And yet even the most cursory reading of the two translations will show that some sort of explanation is necessary because Machado and Pessoa are obviously doing something radically different with Poe's poem. Consider, for example, the two renderings of the first stanza in relation to Poe's original: The Brazilian critic José Guilherme Merquior once claimed that Machado de Assis's translation of "The Raven" should not be considered inferior to the well known translation of the Portuguese poet Fernando Pessoa. 1 Unfortunately Merquior does not seem to find necessary to give reasons for this evaluation. And yet even the most cursory reading of the two translations will show that some sort of explanation is necessary because Machado and Pessoa are obviously doing something radically different with Poe's poem. Consider, for example, the two renderings of the first stanza in relation to Poe's original:

  10. Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

    Science.gov (United States)

    Gonçalves, Nélio; Simões, Ana T; Prediger, Rui D; Hirai, Hirokazu; Cunha, Rodrigo A; Pereira de Almeida, Luís

    2017-03-01

    Machado-Joseph disease (MJD) is a neurodegenerative spinocerebellar ataxia (SCA) associated with an expanded polyglutamine tract within ataxin-3 for which there is currently no available therapy. We previously showed that caffeine, a nonselective adenosine receptor antagonist, delays the appearance of striatal damage resulting from expression of full-length mutant ataxin-3. Here we investigated the ability of caffeine to alleviate behavioral deficits and cerebellar neuropathology in transgenic mice with a severe ataxia resulting from expression of a truncated fragment of polyglutamine-expanded ataxin-3 in Purkinje cells. Control and transgenic c57Bl6 mice expressing in the mouse cerebella a truncated form of human ataxin-3 with 69 glutamine repeats were allowed to freely drink water or caffeinated water (1g/L). Treatments began at 7 weeks of age, when motor and ataxic phenotype emerges in MJD mice, and lasted up to 20 weeks. Mice were tested in a panel of locomotor behavioral paradigms, namely rotarod, beam balance and walking, pole, and water maze cued-platform version tests, and then sacrificed for cerebellar histology. Caffeine consumption attenuated the progressive loss of general and fine-tuned motor function, balance, and grip strength, in parallel with preservation of cerebellar morphology through decreasing the loss of Purkinje neurons and the thinning of the molecular layer in different folia. Caffeine also rescued the putative striatal-dependent executive and cognitive deficiencies in MJD mice. Our findings provide the first in vivo demonstration that caffeine intake alleviates behavioral disabilities in a severely impaired animal model of SCA. Ann Neurol 2017;81:407-418. © 2016 American Neurological Association.

  11. Machado de Assis, moral imagination and the novel

    Directory of Open Access Journals (Sweden)

    José Luiz Passos

    Full Text Available The article discusses the premise behind binding literary value to the ability a work has to yield socio-historical information, prevalent in recent criticism on Machado de Assis. It argues that the body of Machado's work shows an increasing ambivalence regarding the links between imagined lives and history, thus proposing that in his late writings the matching between things real and things represented is a rhetorical and melancholy gesture of great insight. In order to illustrate the prevalence of moral imagination as object and technique in Machado's late novels, the author highlights a few points of contact between Machado de Assis and Henry James, contemporaries and akin in their literary sensibilities.

  12. El anhelo metafísico de Antonio Machado

    OpenAIRE

    Carlos Llano Cifuentes

    2013-01-01

    In Antonio Machado's poetry, a dissatisfied agnosticism appears; that is, a kind of agnosticism which wants to quit being such, an agnosticism with metaphysical longings. Machado knows that the absence of trascendence does not offer peacefulness, but tediousness and resignation against the changing reality. Being lacks the plenitude it once had and, in this sense, there exists in Machado a double way to understand reality: longing for what was and confirmation of the present. All this generat...

  13. El anhelo metafísico de Antonio Machado

    Directory of Open Access Journals (Sweden)

    Carlos Llano Cifuentes

    2013-11-01

    Full Text Available In Antonio Machado's poetry, a dissatisfied agnosticism appears; that is, a kind of agnosticism which wants to quit being such, an agnosticism with metaphysical longings. Machado knows that the absence of trascendence does not offer peacefulness, but tediousness and resignation against the changing reality. Being lacks the plenitude it once had and, in this sense, there exists in Machado a double way to understand reality: longing for what was and confirmation of the present. All this generates a vacuum in the human being, a thirst of trascendence not satisfied and, at the sme time, hope as longing of trascendence which can only be expressed in metaphysics and poetry. Machado's account on trascendence does not exclude immanence. It is found in and from the self, for itself and in other, and even in the absolutely other.

  14. Diagnosis of Joseph disease by means of N-isopropyl-p-[123I]iodoamphetamine (IMP) SPECT

    International Nuclear Information System (INIS)

    Takahashi, Naoya; Nishihara, Mamiko; Odano, Ikuo; Sakai, Kunio; Yuasa, Tatsuhiko.

    1993-01-01

    Using N-isopropyl-p-[ 123 I]iodoamphetamine (IMP) and single-photon-emission computed tomography (SPECT), we studied the regional cerebral blood flow (rCBF) in 4 Japanese patients who had been clinically diagnosed as having Joseph disease. This is the first report of rCBF measurement by means of [ 123 I]-IMP SPECT in patients with Joseph disease. Cerebellar atrophy was evaluated by means of a 5-rating scale as defined by X-ray computed tomography (X-CT). As compared with 10 normal controls (mean cerebellar CBF±SD: 66.9±6.6 ml/100 g/min), the regional CBF of the patients with Joseph disease was found to decrease significantly in the cerebellum (mean±SD: 52.8±5.3 ml/100 g/min). However, no significant relationship was found between the decrease in rCBF in the cerebellum and the degree of cerebellar atrophy as shown by X-CT. The regional CBF in the cerebellum decreased little in one patient who had severe cerebellar atrophy or in two who showed moderate atrophy. [ 123 I]-IMP SPECT demonstrates the pathological and metabolic changes in the cerebellum that do not appear on X-CT or MRI. IMP SPECT is thus shown to be useful for the diagnosis of patients with Joseph disease. (author)

  15. Nucleocytoplasmic shuttling activity of ataxin-3.

    Directory of Open Access Journals (Sweden)

    Sandra Macedo-Ribeiro

    2009-06-01

    Full Text Available Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease (MJD, is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated genes. Disease protein misfolding and aggregation, often within the nucleus of affected neurons, characterize polyglutamine disorders. Several evidences have implicated the nucleus as the primary site of pathogenesis for MJD. However, the molecular determinants for the nucleocytoplasmic transport of human ataxin-3 (Atx3, the protein which is mutated in patients with MJD, are not characterized. In order to characterize the nuclear shuttling activity of Atx3, we performed yeast nuclear import assays and found that Atx3 is actively imported into the nucleus, by means of a classical nuclear localizing sequence formed by a cluster of lysine and arginine residues. On the other hand, when active nuclear export was inhibited using leptomycin B, a specific inhibitor of the nuclear export receptor CRM1, both endogenous Atx3 and transfected GFP-Atx3 accumulated inside the nucleus of a subpopulation of COS-7 cells, whereas both proteins are normally predominant in the cytoplasm. Additionally, using a Rev(1.4-GFP nuclear export assay, we performed an extensive analysis of six putative aliphatic nuclear export motifs identified in Atx3 amino acid sequence. Although none of the tested peptide sequences were found to drive nuclear export when isolated, we have successfully mapped the region of Atx3 responsible for its CRM1-independent nuclear export activity. Curiously, the N-terminal Josephin domain alone is exported into the cytoplasm, but the nuclear export activity of Atx3 is significantly enhanced in a longer construct that is truncated after the two ubiquitin interaction motifs, upstream from the polyQ tract. Our data show that Atx3 is actively imported to and exported from the cell nucleus, and that its nuclear export activity is dependent on a motif

  16. Chronicle and the epic: Machado de Assis in homeric verses

    Directory of Open Access Journals (Sweden)

    Ionara Satin

    2015-12-01

    Full Text Available The aim of this study is to show the presence of classical epic, Homer's Iliad, in the chronicle of Machado de Assis, analyzing the intertextual dialogue between Machado de Assis and the epic poem by Homer, considering the concept of intertextuality developed by Julia Kristeva from philosophical conceptions of Bakhtin. In the chronicle of March 18, 1894 for the newspaper Gazeta de Notícias on sunday column "A Semana", Machado de Assis crosses Homer's epic to his chronicle, rewrites the epic text for the daily issues of his weekly column. To Tiphaine Samoyault, writing is rewriting, "stand on the existing foundations and contribute to a continued creation" (2008, p. 77 one of the principles of intertextuality. It was observed that from the reading and assimilation of the classic poem, Machado de Assis can approach so far genres, bringing the verses to his prose, leaving it closer to poetry. In this sense, we can see the richness of Machado de Assis chronicles, often left on the sidelines in favor of his short stories and romances. In addition, the dialogue, to rewrite the epic in his chronicle, Machado seems to contribute to this "continuous creation", reviving the memory of literature and emphasizing the permanence of classical work.

  17. Development of radiodiagnostics for image diagnosis of intracerebral dopamine receptor

    International Nuclear Information System (INIS)

    Fujita, Motoi; Kitamura, Hideaki; Nakajima, Takashi

    1999-01-01

    By measuring Vd value as an index to catch a functional change of nonspecific amine receptor at pathological regeneration region, Table Look Up method was thought to be useful for evaluation on functions of cerebellum and brainstem in Machado-Joseph disease. As it could simply calculate r-CBF and Vd values only adding SPWCT image to single time artery blood collection, it was thought to be useful for evaluation of Machado-Joseph disease. In last fiscal years, some animal experiments and clinical SPECT were conducted and evaluated to conduct research and development of a receptor imaging chemicals for clinics using radioactive reagent. In 1997 fiscal year, some examination of quantitative image analysis method on Vd value considering to reflex change of neural degeneration and receptor by using SPECT was conducted. (G.K.)

  18. Novel polyglutamine model uncouples proteotoxicity from aging.

    Science.gov (United States)

    Christie, Nakeirah T M; Lee, Amy L; Fay, Hannah G; Gray, Amelia A; Kikis, Elise A

    2014-01-01

    Polyglutamine expansions in certain proteins are the genetic determinants for nine distinct progressive neurodegenerative disorders and resultant age-related dementia. In these cases, neurodegeneration is due to the aggregation propensity and resultant toxic properties of the polyglutamine-containing proteins. We are interested in elucidating the underlying mechanisms of toxicity of the protein ataxin-3, in which a polyglutamine expansion is the genetic determinant for Machado-Joseph Disease (MJD), also referred to as spinocerebellar ataxia 3 (SCA3). To this end, we have developed a novel model for ataxin-3 protein aggregation, by expressing a disease-related polyglutamine-containing fragment of ataxin-3 in the genetically tractable body wall muscle cells of the model system C. elegans. Here, we demonstrate that this ataxin-3 fragment aggregates in a polyQ length-dependent manner in C. elegans muscle cells and that this aggregation is associated with cellular dysfunction. However, surprisingly, this aggregation and resultant toxicity was not influenced by aging. This is in contrast to polyglutamine peptides alone whose aggregation/toxicity is highly dependent on age. Thus, the data presented here not only describe a new polyglutamine model, but also suggest that protein context likely influences the cellular interactions of the polyglutamine-containing protein and thereby modulates its toxic properties.

  19. Novel polyglutamine model uncouples proteotoxicity from aging.

    Directory of Open Access Journals (Sweden)

    Nakeirah T M Christie

    Full Text Available Polyglutamine expansions in certain proteins are the genetic determinants for nine distinct progressive neurodegenerative disorders and resultant age-related dementia. In these cases, neurodegeneration is due to the aggregation propensity and resultant toxic properties of the polyglutamine-containing proteins. We are interested in elucidating the underlying mechanisms of toxicity of the protein ataxin-3, in which a polyglutamine expansion is the genetic determinant for Machado-Joseph Disease (MJD, also referred to as spinocerebellar ataxia 3 (SCA3. To this end, we have developed a novel model for ataxin-3 protein aggregation, by expressing a disease-related polyglutamine-containing fragment of ataxin-3 in the genetically tractable body wall muscle cells of the model system C. elegans. Here, we demonstrate that this ataxin-3 fragment aggregates in a polyQ length-dependent manner in C. elegans muscle cells and that this aggregation is associated with cellular dysfunction. However, surprisingly, this aggregation and resultant toxicity was not influenced by aging. This is in contrast to polyglutamine peptides alone whose aggregation/toxicity is highly dependent on age. Thus, the data presented here not only describe a new polyglutamine model, but also suggest that protein context likely influences the cellular interactions of the polyglutamine-containing protein and thereby modulates its toxic properties.

  20. De crítico a escritor: Machado de Assis, leitor de Shakespeare

    Directory of Open Access Journals (Sweden)

    Vandemberg Simão Saraiva

    2012-10-01

    Full Text Available Machado de Assis foi leitor das peças de Shakespeare, e referências a essa leitura estão presentes em sua crítica dramática e literária. A compreensão de Machado das peças do dramaturgo inglês assumiu nova dinâmica a partir dos espetáculos shakespearianos promovidos por companhias italianas vindas ao Brasil a partir de 1871. Acreditamos que Machado de Assis encontrou na leitura de William Shakespeare muito do que precisava conhecer para produzir sua crítica e sua literatura. De leitor, Machado passa a crítico teatral e literário e escritor de sucesso.

  1. De Swift a Sterne: reflexões sobre o humor britânico na obra de Machado de Assis = From Swift to Sterne: reflections on British humour in the works of Machado de Assis

    Directory of Open Access Journals (Sweden)

    William Valentine Redmond

    2011-01-01

    Full Text Available Os humoristas britânicos, especialmente Swift e Sterne são tradicionalmente vistos como escritores que influenciaram a obra de Machado de Assis. Entretanto, foi o crítico Eugenio Gomes que provou, com precisão, a sutileza e o bom gosto que Machado obteve dessa influência. Em uma abordagem contemporânea, torna-se interessante questionar essa idéia de influência e examinar, à luz da intertextualidade, esse contato do humor entre as obras de Machado e as dessas duas grandes figuras da Literatura na Língua Inglesa.The British humourists, especially Swift and Sterne are traditionallyseen as writers who influenced Machado de Assis’ works. However it was the critic Eugenio Gomes who showed with precision the sublety and excellent taste of Machado obtained through this influence. With our contemporary approaches, it becomes interesting to question the idea of influence and examine in the light of intertextuality this contact of humour between the works of Machado and those of these two great figures of Literature in the English Language.

  2. Five cases of a Joseph disease family with non-REM sleep apnea and MRI study

    International Nuclear Information System (INIS)

    Kitamura, Junichi; Tsuruta, Kazuhito; Yamamura, Yoshinori; Kurihara, Teruyuki; Matsukura, Shigeru

    1987-01-01

    Four male and one female patients of a new Joseph disease family in southern Kyushu are presented. This disorder is inherited by autosomal dominant trait. The clinical symptoms are characterized by bulging eyes, ophthalmoplegia, dysarthria, rigospasticity of the lower limbs, marked dystonia and bradykinesia. In our cases, extrapyramidal symptoms were improved by amantadine and L-Dopa therapy. CSF homovanilic acid (HVA) was markedly reduced. Muscle biopsy and electromyographic studies revealed neurogenic changes. MRI revealed mild atrophy of frontal lobe and cerebellum, and marked atrophy of brain stem. These findings were consistent with the clinical manifestations. Our case had central type sleep apnea by sleep EEG and polygraphic studies. This is the first report about sleep apnea and MRI of Joseph disease. (author)

  3. Five cases of a Joseph disease family with non-REM sleep apnea and MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Kitamura, Junichi; Tsuruta, Kazuhito; Yamamura, Yoshinori; Kurihara, Teruyuki; Matsukura, Shigeru

    1987-09-01

    Four male and one female patients of a new Joseph disease family in southern Kyushu are presented. This disorder is inherited by autosomal dominant trait. The clinical symptoms are characterized by bulging eyes, ophthalmoplegia, dysarthria, rigospasticity of the lower limbs, marked dystonia and bradykinesia. In our cases, extrapyramidal symptoms were improved by amantadine and L-dopa therapy. CSF homovanilic acid (HVA) was markedly reduced. Muscle biopsy and electromyographic studies revealed neurogenic changes. MRI revealed mild atrophy of frontal lobe and cerebellum, and marked atrophy of brain stem. These findings were consistent with the clinical manifestations. Our case had central type sleep apnea by sleep EEG and polygraphic studies. This is the first report about sleep apnea and MRI of Joseph disease.

  4. De olho no bruxo: o cinema brasileiro e a obra de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Eugênio Vinci de Moraes

    2013-12-01

    Full Text Available RESUMOEste artigo apresenta um projeto emestágio inicial de pesquisa sobre as versões cinematográficas baseadas na obrade Machado de Assis. Há cerca de 30 filmes produzidos no Brasil, desde 1939 atéhoje, que partem dos contos e dos romances do escritor fluminense.  O objetivo deste trabalho é identificar,investigar e analisar as contribuições, as modalizações e as recriações que ocinema nacional realizou da obra de Machado de Assis no período anteriormente mcitado, por meio da análise estrutural e contextual. Para isso, será feito umlevantamento inicial dessas obras, uma catalogação de todos elementos queconcernem à produção do filme, para em seguida analisarem-se as leituras que osdiretores fizeram da obra de Machado. Aqui serão discutidas as premissas quefundamentarão essas análises. Entre elas, as ideias de adaptação, fidelidade eleitura e outras. As análises serão feitas com base em categorias narrativas,discutidas a partir de obras de Ismail Xavier, Robert Stam, Juracy A. Saraiva,entre outros.Palavras-chave: Machado de Assis. Cinema brasileiro. Narrativa. Adaptação. ABSTRACT This article presents a project in its early stage of research on thecinematographic versions based on the work of Machado de Assis. There have beenapproximately 30 films produced in Brazil since 1939 until today, based on thetales and novels written by the author. The objective of this work is toidentify, investigate and analyze the contributions, the modalizations and therecreations that the Brazilian cinema has done in relation to the work ofMachado de Assis in the period previously cited, by means of structural andcontextual analysis. For this reason, it will be made an initial survey ofthese works, a cataloguing of all elements concerning the film production.Then, it will be examined the interpretation by the film directors on the workof Machado de Assis. In this paper, the assumptions that sustain these analyzeswill be discussed

  5. O estudo das fontes estrangeiras na obra de Machado de Assis e o caso italiano

    Directory of Open Access Journals (Sweden)

    Eugênio Vinci de Moraes

    2008-04-01

    Full Text Available Os estudos das fontes italianas na obra de Machado de Assis ainda são uma esquecida árvore no meio da floresta dos estudos machadianos. Três aspectos explicam talvez a posição marginal dessas pesquisas: primeiro, o número menor de refer~encias italianas perante as inglesas e francesas, por exemplo; segundo, a ausência de estudos de maior fôlego; por último, por essa fonte não tocar nas questões centrais da obra de Machado. Neste artigo pretende-se mostrar de que forma trabalhar com as fontes em Machado, com base em três modelos de análise, e também de que forma esses estudos podem tocar, sim, em pontos fundamentais da obra de Machado, desde que não se desdenhe a já alentada e qualificada fortuna crítica do escritor fluminense.

  6. Clinical and molecular characteristics of a Brazilian family with spinocerebellar ataxia type 1 Características clínicas e moleculares de uma família Brasileira com ataxia espinocerebelar tipo 1

    Directory of Open Access Journals (Sweden)

    Iscia Lopes-Cendes

    1996-09-01

    Full Text Available The spinocerebellar ataxias (SCAs are a clinically and genetically heterogeneous group of late onset neurodegenerative disorders. To date, seven different genes causing autosomal dominant SCA have been mapped: SCA1, SCA2, Machado-Joseph disease (MJD/SCA3, SCA4, SCA5, SCA7 and dentatorubropallidoluysian atrophy (DRPLA. Expansions of an unstable trinucleotide CAG repeat cause three of these disorders: SCA1, MJD/SCA3 and DRPLA. We studied one Brazilian family segregating an autosomal dominant type of SCA. A total of ten individuals were examined and tested for the presence of the SCA1, MJD and DRPLA mutations. Three individuals, one male and two females, were considered affected based on neurological examination; ages at onset were: 32, 36 and 41 years. The first complaint in all three patients was gait ataxia which progressed slowly over the years. Six individuals showed one allele containing an expanded CAG repeat in the SCA1 gene. The mean size of the expanded allele was 48.2 CAG units. Instability of the expanded CAG tract was seen in the two transmissions that were observed in this family. In both occasions there was a contraction of the CAG tract. Our study demonstrates that SCA1 occurs in the Brazilian population. In addition, our results stress the importance of molecular studies in the confirmation of diagnosis and for pre-symptomatic testing in SCAs.As ataxias espinocerebelares (AECs fazem parte de um grupo de doenças neurodegenerativas que apresentam grande heterogeneidade clínica e genética. Existem até o momento sete genes mapeados responsáveis pelas AECs de transmissão autossômica dominante: SCA1, SCA2, doença de Machado-Joseph (DA/7 ou SCA3, SCA4, SCA5, SCA7 e atrofia dentatorubropalidoluisiana (ADRPL. Uma expansão de um trínucletídeo CAG foi identificada como a mutação responsável na SCA], DMJ e ADRPL. Estudamos uma família brasileira com uma forma autossômica dominante de AEC. Dez indivíduos foram examinados e

  7. A ESCRITURA ERÓTICA EM MACHADO DE ASSIS

    Directory of Open Access Journals (Sweden)

    Norberto Perkoski

    2008-11-01

    Full Text Available Neste artigo, analisam-se contos de Machado de Assis, com o enfoque no mistério das personagens femininas, que se constituem para as figuras masculinas como enigmáticas, incapazes que são de compreender-lhes as oscilações da alma. Aborda-se também o processo de criação textual de Machado, que se esconde através de ambigüidades e eufemismos, o que permite entendê-lo como uma escritura erótica transgressora em hipo, ou seja, os elementos da narrativa se subordinam à sugestão, priorizando a transgressão insinuada, em que o implícito engendra possibilidades interpretativas polissêmicas, de que “Missa do galo”, pela estrutura lacunar que permeia o conto, se institui como exemplo paradigmático.

  8. The counselor’s aporia: the end of the chronicler Machado de Assis

    Directory of Open Access Journals (Sweden)

    Júlio França

    2008-12-01

    Full Text Available On 28th February 1897, Machado de Assis leaves the “Gazeta de Notícias”, closing a period of thirty-eight years of regular colaboration with the city’s press. His leaving is enigmatic and has been interpreted in various ways by the literary studies. This article aims to discuss the reasons which led Machado to abandon the crônica and also demonstrate that some features of this type of writing had a direct influence in the production of his three last novels, published after February 1897.

  9. Joseph Mountin Lecture

    Centers for Disease Control (CDC) Podcasts

    2009-10-26

    In this podcast, William H. Foege, MD, MPH delivers the 29th Annual Joseph W. Mountin Lecture. Dr. Foege was a key leader in the smallpox effort and worked as an epidemiologist in the successful eradication campaign in the 1970s. Dr. Foege became chief of the Smallpox Eradication Program at CDC, and was appointed director of CDC in 1977.  Created: 10/26/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 10/29/2009.

  10. A ironia trágica de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Patrick Pessoa

    2007-04-01

    Full Text Available O texto defende, a partir de uma análise das Memórias póstumas de Brás Cubas, de Machado de Assis, que a ironia do autor deve ser lida como uma espécie de ironia trágica. A fundamentação dessa hipótese é realizada em três etapas: na primeira, apresenta-se o conceito de ironia trágica, como tematizado por Christoph Menke e Wayne Booth; na segunda, mostra-se como a noção de ironia trágica permite compreender a célebre definição de Lukács de que “a ironia é a objetividade do romance”; finalmente, o texto discute como o conceito de ironia trágica ao mesmo tempo esclarece e subverte as interpretações tradicionais da obra de Machado de Assis.

  11. Colonel Don Benito Machado. A National Guards commandant on the southern frontier of Buenos Aires [1852-1880] El coronel Don Benito Machado. Un comandante de Guardias Nacionales en la frontera sur bonaerense [1852-1880

    Directory of Open Access Journals (Sweden)

    Leonardo Canciani

    2012-01-01

    Full Text Available In this work, we will analyze the National Guard regiments and the role played by their commandants during the process of national organization on the southern frontier of Buenos Aires, from the case study of coronel don José Benito Machado. First of all, our objective will be describe the specific characteristics that adopted the National Guards in the societies of the southern frontier of the province of Buenos Aires. And then, to analyze the mechanisms developed by Benito Machado to build the power bases in the region that enabled the consolidation of its leadershipEn el presente trabajo, analizamos los regimientos de Guardias Nacionales y las funciones que desempeñaron sus comandantes durante el proceso de organización nacional en la frontera sur bonaerense, desde el estudio de caso del coronel don José Benito Machado. En primer lugar, repasamos las características específicas que adoptaron las Guardias Nacionales en las sociedades de la frontera sur de la provincia de Buenos Aires; mientras que, en segundo lugar, analizamos los diversos mecanismos desarrollados por Benito Machado para construir las bases de poder en la región que posibilitaron el afianzamiento de su liderazgo

  12. Antonio Machado: muerte y supervivencia

    OpenAIRE

    López Castro, Armando

    2005-01-01

    566 p. La vida es como el Fenix, siempre renace de su propia muerte. La verdadera naturaleza de la vida es la resurrección. Este principio, clave del pensamiento cristiano, se va a desarrollar con la conciencia simbólica, que consiste en rememorar la unidad desde la dispersión. No es casual que un espíritu cristiano como el de Machado, estuviese próximo a la figura de Cristo, que nos hace pasar de la muerte a la vida, y practicase una escritura destinada a transformar lo histórico en busca...

  13. The construction of a canon for the brazilian nineteenth century: the power of Machado de Assis

    Directory of Open Access Journals (Sweden)

    ANDRÉA SIRIHAL WERKEMA

    2015-08-01

    Full Text Available This paper discusses the readings of the Brazilian literary history through the eyes of Machado de Assis: although a little too obvious, the hypotheses that arise show that Machado, as a literary critic, was already aware of a continuum in our literary history, as one can read in “Instinto de nacionalidade” (1873 as well as in “A nova geração” (1879. That would have undeniable impact in his fictional work, since he would use his appreciation of his literary surroundings as a way to change and improve his writings. We could attest, therefore, that Machado de Assis is directly responsible for our literary canon in the Nineteenth Century, which he influenced posthumously – through his readers – but also as a willing agent.

  14. Outros textos encontrados de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Jean-Michel Massa

    Full Text Available Neste texto, publicado anteriormente apenas em francês pelo professor Jean-Michel Massa, acrescentam-se algumas peças não incluídas em seu famoso Dispersos de Machado de Assis (Rio de Janeiro, 1965. Com tradução anotada de Lúcia Granja, o texto se publica aqui pela primeira vez em português, apresentando ao leitor um pouco da produção machadiana não reunida em volume pelo autor.

  15. 'The stumbling disease': a case study of stigma among Azorean-Portuguese.

    Science.gov (United States)

    Boutté, M I

    1987-01-01

    There exists among Azorean-Portuguese a biological malady that is inherited. First recognized by biomedicine in 1972 as a distinct disease entity, it has been in existence in the United States and the Azores Islands since at least the mid-1800s. The malady is generally known as the 'stumbling disease' among the Azorean-Portuguese; the current biomedical literature refer to it as Machado-Joseph disease. Historically an aura of stigma has surrounded affected individuals, their families, and primary ethnic group in which the malady is currently found. Drawing heavily on the work of Erving Goffman Stigma: Notes on the Management of Spoiled Identity. Prentice-Hall, Englewood Cliffs, N.J., 1963) and labelling theory, this paper explores the nature of this stigma. The cultural contexts of a small, face-to-face, homogeneous island setting is contrasted with that of the heterogeneous, anonymous setting of the United States to illuminate various aspects of the stigma configuration. The cultural context has important implications for stigma definitions, modes of social control, and management strategies of the stigmatized.

  16. Machado de Assis, leitor e crítico de teatro

    Directory of Open Access Journals (Sweden)

    João Roberto Faria

    2004-08-01

    Full Text Available O PRESENTE estudo tem como objetivo principal traçar o perfil de Machado de Assis enquanto leitor e crítico de teatro. Para tanto, primeiramente situa-o no contexto teatral dos anos de 1850 e 1860 do século XIX, quando entraram em choque, nos palcos do Rio de Janeiro, a estética romântica e a realista. Depois, acompanha sua extensa produção jornalística, na qual se notabilizou como crítico teatral e folhetinista, detendo-se também na atividade de censor do Conservatório Dramático Brasileiro que o escritor exerceu por algum tempo. Ao acompanhar o percurso intelectual de Machado, em sua juventude literária, procuramos analisar, compreender e explicar suas idéias em relação à arte dramática e ao teatro brasileiro.THIS ESSAY aims to draw a profile of Machado de Assis as a reader and critic of theatrical works. We begin by observing Assis in the theatrical milieu of the 1850s and 1860s, the time of the onslaught between the Romantic and Realist aesthetics in the stages of Rio de Janeiro. We then view his extensive production as journalist, when he distinguished himself as a drama critic and writer of feuilletons, and also his activity as censor of the Brazilian Drama Conservatoire, a post he held for a short period. By following Assis' intellectual journey during his literary youth, we have attempted to analyze, understand and explain his ideas toward the dramatic arts in general and the Brazilian theater in particular.

  17. The nucleus raphe interpositus in spinocerebellar ataxia type 3 (Machado-Joseph disease)

    NARCIS (Netherlands)

    Rub, U; Brunt, ER; Gierga, K; Schultz, C; Paulson, H; de Vos, RAI; Braak, H

    The nucleus raphe interpositus (RIP) plays an important role in the premotor network for saccades. Its omnipause neurons gate the activity of the burst neurons for vertical saccades lying within the rostral interstitial nucleus of the medial longitudinal fascicle and that for horizontal saccades

  18. Assis, Machado de. Ressurrection by Machado de Assis. Trad. Karen Sherwood Sotelino. Pittsburgh: Latin American Literary Review Press, 2013. 162 p.

    Directory of Open Access Journals (Sweden)

    Cynthia Beatrice Costa

    2015-12-01

    Full Text Available Resenha crítica da primeira e única tradução para o inglês do romance machadiano Ressurreição, publicado em 1872. Lançada em 2013, a tradução da professora da Universidade de Stanford Karen Sherwood Sotelino chamou a atenção de estudiosos de Machado por mostrar como a obra do autor brasileiro desperta interesse atual no mundo anglófono.

  19. Juan Rulfo and Machado de Assis: Toward an Integrated New Narrative

    Science.gov (United States)

    Wiseman, David P.; Krause, James R.

    2016-01-01

    Despite apparent connections between Brazilian and Spanish American narratives, comparative scholarship has only recently begun to investigate actively these important points of contact. In this study, we introduce a vital crossover between the two traditions, involving Juan Rulfo and Joaquim Maria Machado de Assis. Rulfo's outspoken affinity for…

  20. Population genetics and new insight into range of CAG repeats of spinocerebellar ataxia type 3 in the Han Chinese population.

    Directory of Open Access Journals (Sweden)

    Shi-Rui Gan

    Full Text Available Spinocerebellar ataxia type 3 (SCA3, also called Machado-Joseph disease (MJD, is one of the most common SCAs worldwide and caused by a CAG repeat expansion located in ATXN3 gene. Based on the CAG repeat numbers, alleles of ATXN3 can be divided into normal alleles (ANs, intermediate alleles (AIs and expanded alleles (AEs. It was controversial whether the frequency of large normal alleles (large ANs is related to the prevalence of SCA3 or not. And there were huge chaos in the comprehension of the specific numbers of the range of CAG repeats which is fundamental for genetic analysis of SCA3. To illustrate these issues, we made a novel CAG repeat ladder to detect CAG repeats of ATXN3 in 1003 unrelated Chinese normal individuals and studied haplotypes defined by three single nucleotide polymorphisms (SNPs closed to ATXN3. We found that the number of CAG repeats ranged from 13 to 49, among them, 14 was the most common number. Positive skew, the highest frequency of large ANs and 4 AIs which had never been reported before were found. Also, AEs and large ANs shared the same haplotypes defined by the SNPs. Based on these data and other related studies, we presumed that de novo mutations of ATXN3 emerging from large ANs are at least one survival mechanisms of mutational ATXN3 and we can redefine the range of CAG repeats as: ANs≤44, 45 ≤AIs ≤49 and AEs≥50.

  1. Machado de Assis' homeopathic narrators

    Directory of Open Access Journals (Sweden)

    Paul Dixon

    Full Text Available Machado showed a fascination with homeopathic medicine, an indirect form of treatment that uses agents to stimulate reactions similar to the symptoms of the condition to be cured. Several of the author’s texts show a pattern of projects realized by indirect means, by "like curing like", which suggests a homeopathic logic in Machado’s worldview. Certain narrators, such as those inMemórias póstumas de Brás Cubas, Dom Casmurro, and in short stories such as "O segredo do bonzo" and "Adão e Eva", are notable for denouncing themselves, that is, for undermining their own validity. This curious situation has implications for Machado’s overall project, which seems more interested in posing questions than providing answers. It also suggests a particular relationship with the reader, which affords as much independence as possible.

  2. Total hip replacement for Mseleni Joint Disease undertaken in a ...

    African Journals Online (AJOL)

    The objective of this project was to ascertain whether it is reasonable to perform specialist surgery for Mseleni Joint Disease (MJD) in a rural hospital by assessing the medium-term outcome of surgery for MJD performed at Mseleni. The study was designed as a review of patients at Mseleni Hospital in rural KwaZulu Natal, ...

  3. Assis, Machado de. Ressurrection by Machado de Assis. Trad. Karen Sherwood Sotelino. Pittsburgh: Latin American Literary Review Press, 2013. 162 p.

    Directory of Open Access Journals (Sweden)

    Cynthia Beatrice Costa

    2015-05-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2015v35n2p494 Resenha crítica da primeira e única tradução para o inglês do romance machadiano Ressurreição, publicado em 1872. Lançada em 2013, a tradução da professora da Universidade de Stanford Karen Sherwood Sotelino chamou a atenção de estudiosos de Machado por mostrar como a obra do autor brasileiro desperta interesse atual no mundo anglófono.

  4. Epilepsy and stigma: an approach to understanding through the life and works of the Brazilian writer Machado de Assis (1839-1908).

    Science.gov (United States)

    Yacubian, Elza Márcia Targas; Caboclo, Luis Otávio Sales Ferreira

    2011-03-01

    Machado de Assis (1839-1908)-novelist, short story writer, essayist, and poet-is a fascinating personality. Had he written in French, English, German, or Italian, he would have achieved universal fame and would be in the same company as Balzac, Tolstoy, Dickens, and Dostoevsky. This article discusses stigma in epilepsy through Machado de Assis' life, literary work, and letters to other Brazilian writers. Founder of the Brazilian Academy of Letters, Machado offers an insoluble enigma to psychologists and essayists. Born in stark poverty, feeble, and ugly, he had to fight the taint of epilepsy. The documentation of epilepsy in Machado de Assis' texts and letters and the testimony of his contemporaries is unique, allowing the comprehension of scientific concepts and stigma related to epilepsy in the 19th century, when the positivist ideas of the Italian neuropsychiatrist Cesare Lombroso (1835-1909) permeated nascent Brazilian neuropsychiatry. Much of the stigma associated with epilepsy we witness today emerged from these concepts. Even today in Brazil, when barbaric crimes are committed, headlines in newspapers produced by forensic psychiatrists often attribute the conduct of the criminal to epileptic behavior. Copyright © 2011 Elsevier Inc. All rights reserved.

  5. Machado: do discurso romântico da nacionalidade à crítica radical da nação

    Directory of Open Access Journals (Sweden)

    João Hernesto Weber

    Full Text Available O artigo se detém, inicialmente, numa leitura da camada aparente de "Instinto de nacionalidade", destacando sua vinculação com as teses românticas sobre o sentido de "nação" e "literatura nacional", insistindo Machado na literatura indigenista, na cor local, na feição americana como paradigma para detectar a nacionalidade do texto literário. Em outra camada de leitura, apontam-se as reticências, as negações, o estilo carregado de adversativas que permeiam o texto, a ponto de Machado vir a negar as teses românticas em sua exclusividade, para, finalmente, abrir o leque do que poderia significar "literatura nacional": tudo é matéria de poesia. Na sequência, analisa-se a formação do Machado ficcionista, quando viria a exercitar o que já se encontrava, em tese, no "Instinto". Por fim, lançam-se algumas questões sobre a importância do ensaio para a crítica e a historiografia literária locais.

  6. Machado de Assis e a psiquiatria: um capítulo das relações entre arte e clínica no Brasil Machado de Assis and psychiatry: a chapter in the relations between art and clinical practice in Brazil

    Directory of Open Access Journals (Sweden)

    Elizabeth Maria Freire de Araújo Lima

    2009-09-01

    Full Text Available Em Machado de Assis, a loucura, seu lugar na sociedade de então e as tênues fronteiras que a separam da razão tornaram-se preocupação constante a partir de 1880, quando houve uma inflexão em sua obra. Por outro lado, o escritor foi referido inúmeras vezes em estudos clínicos interessados na investigação das relações entre arte e loucura. Neste artigo, indico de forma breve a visão da psiquiatria brasileira a respeito das artes, dos artistas e do processo de criação nas primeiras décadas do século XX. E apresento três estudos dedicados ao escritor Machado de Assis e sua obra, produzidos nesse período por psiquiatras que interpretaram fenômenos artísticos sob o ponto de vista da psicopatologia, buscando explicitar a lógica interna a essas abordagens.Madness, its place in society, and the tenuous boundaries separating it from reason became a constant concern in Machado de Assis' literary production as of 1880, when a shift can be observed in his work. Clinical studies exploring the relations between art and madness have mentioned this writer countless times. The article offers an overview of Brazilian psychiatry's perception of the arts, artists, and the creative process in the early decades of the twentieth century. It presents three studies on Machado de Assis and his works, written during that period by psychiatrists who interpreted artistic phenomenon from the perspective of psychopathology, and endeavors to identify the inner logic of these approaches.

  7. Análise Morfométrica da Rede de Drenagem da Bacia do Rio do Machado-MG / Morphometric Analisys of Machado Drainage Basin – Minas Gerais State

    Directory of Open Access Journals (Sweden)

    Marli Carina Siqueira Ribeiro

    2010-04-01

    Full Text Available Este artigo visa analisar a rede de drenagem através da utilização das técnicas de indice Relação Declividade e Extensão do Curso de agua (RDE e análise do perfil longitudinal dos vales, numa região chave do Planalto Sul de Minas, a fim de contribuir com estudos sobre evolução da paisagem da região sudeste do Brasil. A pesquisa foi realizada na Bacia Hidrográfica do Rio do Machado (MG, afluente do Alto Rio Grande, e regiões adjacentes, localizadas no Planalto Sul de Minas. O Rio do Machado apresenta uma particularidade em seu curso, com uma mudança brusca de direção tomada por sua drenagem na área próxima ao seu médio curso. Com a aplicação das técnicas pretende-se compreender melhor a dinâmica do relevo na área, identificando áreas com indício de ação neotectônica e seu padrão de distribuição na bacia.

  8. Jacques Joseph: Father of modern aesthetic surgery

    Directory of Open Access Journals (Sweden)

    Bhattacharya Surajit

    2008-10-01

    Full Text Available When we review the history of modern aesthetic surgery, a name that stands out as bright as a beacon and precious as gold is undoubtedly that of Jacques Joseph. A surgeon, par excellence, far ahead of his time, who chose to think out of the box, Joseph, despite all odds set out to give respectability to Aesthetic Surgery without depriving it of any scientific core values. By his words and deeds proved beyond doubt that only the very best in the field of reconstructive surgery, can visualize the hidden perfection in imperfection and formulate a treatment plan and a surgical strategy to achieve that elusive perfection. The rich surgical literature that he has left behind, the wealth of surgical instruments that he had designed and above all a way of thinking that he propagated, that aesthetic surgery is not frivolous but very serious endeavor, and treating the psychology of the patient is as important as treating his disease, undoubtedly makes him the revered ′Father of Modern Aesthetic Surgery′.

  9. MACHADO DE ASSIS: CRÊS EM SONHOS?

    Directory of Open Access Journals (Sweden)

    Teresinha V. Zimbrão da Silva

    2010-05-01

    Full Text Available Nesse artigo, trabalharemos com duas áreas de conhecimento, Literatura e Psicologia. Nossa proposta, portanto, é interdisciplinar: pretendemos analisar o conto intitulado Um Sonho e Outro Sonho, publicado no jornal A Estação (1892, da autoria do escritor Machado de Assis (1839-1908, do ponto de vista da Psicologia de Carl Gustav Jung (1875-1961, sobretudo, utilizaremos o conceito junguiano de Individuação. Por meio desse artigo, esperamos chamar a atenção para a importância dos estudos que trabalham com a interdisciplinaridade da Literatura e da Psicologia, como também esperamos estar divulgando a Crítica Literária Junguiana dentro dos Estudos Literários Brasileiros.

  10. Dois marranos e um bruxo: Antônio José e Baruch Espinosa na poesia de Machado de Assis

    OpenAIRE

    Kênia Maria de Almeida Pereira

    2012-01-01

    A poesia de Machado de Assis ainda é pouco estudada e compreendida nas pesquisas acadêmicas. Dentre as dezenas de poemas homenageando importantes escritores canônicos, presentes no livro Ocidentais, interessa-nos dois em especial para nossos comentários: “Antônio José” e “Espinosa”. Machado de Assis dialoga com a obra desses dois escritores, apontando também para o fato de que tanto Antônio José como Espinosa pertenceram a famílias de cristãos-novos e foram perseguidos pela intolerância relig...

  11. Fantasmas de si mesmo: uma leitura demoníaca de James e de Machado

    Directory of Open Access Journals (Sweden)

    Marcelo Pen Parreira

    Full Text Available Este artigo prossegue na discussão sobre o papel do duplo no mundo desencantado da era liberal. Por meio da análise de algumas histórias de Henry James e de Machado de Assis, ele investiga a figuração do sujeito, esvaziado e iludido, assombrado por seu outro eu mutilado - imagem replicada tornada pavorosa pelo horror que o homem moderno comete contra si próprio. As narrativas de Machado, além disso, ao evocar personagens como que possuídos por vestígios de sua "herança bestial" ou por projeções de feitos mundanos (que eles metonimicamente tomam como sua essência integral, desestabilizam ainda mais o conceito de individuação. Nos dois autores, lidar com esse paradoxo também significa conduzir a narrativa a seus momentos negativos ou de falência, quando narrar deixa de ser possível.

  12. Joseph Dzhugashvili (Stalin and the Terror

    Directory of Open Access Journals (Sweden)

    Teimuraz Vakhtangishvili

    2014-08-01

    Full Text Available Joseph Vissarionovich Dzhugashvili (Stalin was born in Georgia, where he spent the significant part of his life. Materials and documents, preserved in the funds of the Central Historic Archive of Georgia and in the Archive of the Ministry of Internal Affairs of Georgia, which haven’t been published yet, present a new view of Joseph Dzhugashvili’s (Stalin revolutionary activities during the revolution of 1905-1907. The mentioned documents state the fact that the Bolsheviks and the Mensheviks made active use of terrorist methods and acts against tsar’s government. Besides, the archive materials, we have obtained, state that young Joseph Dzhugashvili (Stalin while residing in Georgia was involved in the organization of military struggle and terrorist acts against government by the socially-democratic party of the Bolsheviks.

  13. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    Science.gov (United States)

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  14. Reflective Mindreading: Theory of Mind and the Search for Self in Antonio Machado's "Soledades"

    Science.gov (United States)

    Mills, Steven

    2011-01-01

    In Antonio Machado's collection "Soledades", the poet's search for identity guides an introspective quest where context, body, and mind form an intricate and inseparable connection. By extending cognitive capabilities to his natural environment, the poet, through embodied cognition and Theory of Mind, reads other people's and nature's minds to…

  15. Número de homenagem a Carla Machado : Nota de abertura

    OpenAIRE

    Matos, Marlene; Gonçalves, Rui Abrunhosa

    2012-01-01

    Através deste número especial, pretendemos homenagear Carla Machado, uma autora de referência incontornável na sua área de conhecimento, a Psicologia da Justiça. Fortemente empenhada com a ciência nacional, a Carla marcou a agenda académica e científica dos últimos 20 anos e os seus contributos permanecerão no trabalho de todos aqueles que se dedicam a esta área do saber. É da sua autoria um conjunto de publicações nacionais pioneiras no domínio da Vitimologia (“Novas formas de...

  16. Da tragédia à comédia: uma leitura do conto "A cartomante", de Machado de Assis

    Directory of Open Access Journals (Sweden)

    EDER RODRIGUES PEREIRA

    Full Text Available Resumo O presente artigo estabelece uma relação comparativista entre o conto "A cartomante", de Machado de Assis, e a tragédia Hamlet, de Shakespeare, utilizando para isso alguns conceitos da poética clássica, da teoria dos gêneros e da estilística. Com isso, observamos o modo como determinados elementos estruturais e temáticos existentes na peça de Shakespeare assumem uma nova dimensão no conto de Machado que, além de realizar um diálogo com a tragédia shakespeariana, reaviva diversas questões de ordem estética e ideológica.

  17. ALMAS EXTERIORES. UMA REFLEXÃO SOBRE MODA E ESCRITURA EM MACHADO DE ASSIS

    Directory of Open Access Journals (Sweden)

    ÉLIDE VALARINI OLIVER

    Full Text Available Resumo Os elementos da indumentária em Machado ultrapassam o mero acessório para assumirem um manancial de significações que os atraem para o centro mesmo da construção da narrativa. Qual a função dos qualia ? São tais elementos contingentes, acessórios ou necessários?

  18. DEBATES EM TORNO DA TEORIA RACIAL E URBANIZAÇÃO NA SÉRIE DE CRÔNICAS “BONS DIAS!” DE MACHADO DE ASSIS

    Directory of Open Access Journals (Sweden)

    Sálua Francinele Ribeiro

    2016-12-01

    Full Text Available The objective of this research is to investigate positions taken by the narrator of the series “Bons dias!”, Policarpo, created by Machado de Assis, referring to: racial theory, epidemics and science in nineteenth century Brazil. We will take as corpus the chronicles of the series “Bons dias!”, that approach these subjects.The slavery abolition, which occurred on May 13, 1888, among other changes that were taking place in Brazil during the late nineteenth century, such as the discussion regarding the urbanization of Rio de Janeiro city, the fight against epidemics that were devastating the city (yellow fever and malaria, and the debates regarding racial theories allowed the series of chronicles “Bons dias!” to build meanings amongst the readers regarding the latest events.With the analysis of the chosen chronicles it is possible to approach the opinions of Machado de Assis on the events of his time. Machado, “in the voice” ironic of Policarpo, observed and commented on the analyzed themes, being contrary to several opinions of the ruling elite of nineteenth-century Brazil, regarding racial theory, epidemics and science in Brazil. Machado de Assis, through his character, Policarpo, proved to be a critic of various attitudes of the ruling class.

  19. Ludwig Boltzmann, Albert Einstein and Franz Joseph; Ludwig Boltzmann, Albert Einstein und Franz Joseph

    Energy Technology Data Exchange (ETDEWEB)

    Broda, E.

    1983-07-01

    Under the Emperor Francis Joseph (1848-1916) the natural sciences were less weIl supported in Austria than in other countries of Europe. This is explained by the fact that the German speaking middle classes accepted the preeminence of the feudal forces with their antiscientific attitude. The reason for this readiness to subordination was that those middle classes feIt threatened in their relatively favourable situation by Slavs and Latins. Francis Joseph was the typical representative of the aristocracy. Personally, he did his duty conscientiously and was not corrupt, but progressive ideas and scientific thought were alien to him. From his desk he treated Boltzmann benevolently, but he had no wish to meet personally the greatest mind of the Empire or in any respect to ask his views. Another famous subject of the Emperor, Albert Einstein, was apparently ignored altogether. The structural weakness of Austria, due to the national problems, led to immobilism in her scientific life, but also, up to a point, to tolerance. The impression of Victor Adler on Einstein is considered in this historical context. (author) [German] Die Naturwissenschaften wurden in Österreich unter Franz Joseph (1848-1916) weniger gefördert als in anderen Staaten Europas. Dies wird darauf zurückgeführt, daß das deutschsprechende Bürgertum sich mit der Vorherrschaft der feudalen Kräfte abfand, die nicht wissenschafts-freundlich waren. Für die Bereitschaft zur Unterordnung unter die Feudalen war maßgebend, daß das deutschsprechende Bürgertum sich durch Slawen und Romanen in seiner relativen Vorzugsstellung bedroht sah. Franz Joseph war der typische Repräsentant des konservativen Feudalismus. Er war persönlich pflichtbewußt und integer, doch waren ihm fortschrittliche Gedanken und wissenschaftliche Denkweise fremd. Boltzmann behandelte er von seinem Schreibtisch aus wohlwollend, doch hegte er keinen Wunsch, den größten Geist seines Reiches persönlich kennen zu lernen oder ihn in

  20. Quando o crítico se retira da plateia: a desilusão de Machado de Assis com o teatro

    Directory of Open Access Journals (Sweden)

    Franceli Aparecida da Silva Mello

    Full Text Available A implantação de um teatro nacional de alto nível fez parte de um projeto político que a geração de Machado de Assis abraçou com entusiasmo, qual fosse o da modernização da sociedade com vistas à inserção do Brasil no "mundo civilizado". Neste artigo procuro demonstrar em que medida Machado de Assis engajou-se nesse projeto através de sua crítica teatral, bem como discutir as razões de seu afastamento do teatro a partir de um determinado momento de sua vida.

  1. A produção da erva mate (ilex paraguariensis no contexto da agricultura familiar no município de Cruz Machado-PR

    Directory of Open Access Journals (Sweden)

    Vanderlei Marinheski

    2017-04-01

    Full Text Available A pesquisa teve como objetivo geral avaliar participação da erva mate (Ilex paraguariensis no contexto econômico do Município de Cruz Machado no estado do Paraná, suas perspectivas de desenvolvimento local e geração de renda no sistema de agricultura familiar. A metodologia utilizada foi a pesquisa bibliográfica e consulta on line nos principais órgão e secretárias, mais o trabalho de campo com a averiguação de algumas propriedades rurais do município de Cruz Machado. Nos sistemas de agricultura familiar a logística das ocupações do relevo está associada às características geomorfológicas e ao tamanho das propriedades agropecuárias. Em Cruz Machado predomina o sistema de agricultura familiar, e a erva mate sempre foi uma alternativa extra na complementação da renda dos produtores, e no ano de 2013 contribuiu em mais de 15% do PIB anual do município. E hoje a produção da erva mate representa uma complementação na renda das famílias do município de Cruz Machado, mas que poderá ter uma maximização de produção aliada a características geoecológicas da região e contribuir para o desenvolvimento local.       

  2. Resenha do livro: 'Catálogo dos folhetos da Coleção Barbosa Machado. Anais da Biblioteca Nacional'

    Directory of Open Access Journals (Sweden)

    Erasmo D'Almeida Magalhães

    1977-03-01

    Full Text Available (primeiro parágrafo do texto As investigações e trabalhos levados a cabo por Rosemaire Horch, responsável pela publicação de Sermões impressos dos autos da fé (Rio de Janeiro, 1960 e dos primorosos Catálogos da Brasiliana da Coleção Barbosa Machado (Rio de Janeiro, 1967 e dos Vilancicos da Coleção Barbosa Machado (Rio de Janeiro, 1969, tem revelado a importância da função da bibliotecária que não se atem tão somente a problemas de ordem técnica secundária, mas antes, torna a biblioteca um organismo vivo e dinâmico.

  3. O GUME DA IRONIA EM MACHADO DE ASSIS E JANE AUSTEN

    Directory of Open Access Journals (Sweden)

    SANDRA GUARDINI TEIXEIRA VASCONCELOS

    Full Text Available A partir de uma observação de John Gledson, que sugere "uma profunda afinidade entre Machado de Assis e Austen, sobretudo em sua ironia onipresente, meticulosa e implicitamente agressiva" (cf. "A parasita azul", tenciono investigar o potencial dessa afinidade, interrogando os usos que ambos fizeram da ironia como arma de crítica social e as possíveis diferenças que se podem estabelecer entre o modo como cada escritor a mobiliza para dar conta de representar o mundo que era o seu.

  4. Jean Baptiste Joseph Fourier

    Science.gov (United States)

    Sterken, C.

    2003-03-01

    This paper gives a short account of some key elements in the life of Jean Baptiste Joseph Fourier (1768-1830), specifically his relation to Napoleon Bonaparte. The mathematical approach to Fourier series and the original scepticism by French mathematicians are briefly illustrated.

  5. Joseph Conrad's Lord Jim: Reconsiderations

    Directory of Open Access Journals (Sweden)

    Ali Albashir Mohammed Al-Haj

    2014-12-01

    Full Text Available The present study aims at reconsidering critically Joseph Conrad's Lord Jim. Joseph Conrad is a great master of English prose who writes normally of the sea, of the Eastern islands, of the English character as seen against a background of the exotic or faced with difficulties. The power of Conrad's feelings for Jim, as well as the force of his judgment  against him, are the responses  of a man mightily involved on two planes, one personal and one public , with the dynamics of good and evil. The evil in Lord Jim is one thing on the surface and another beneath our grasp. It is of course the evil of men who have no sense of loyalty to anything.

  6. A produção da erva mate (ilex paraguariensis) no contexto da agricultura familiar no município de Cruz Machado-PR

    OpenAIRE

    Vanderlei Marinheski

    2017-01-01

    A pesquisa teve como objetivo geral avaliar participação da erva mate (Ilex paraguariensis) no contexto econômico do Município de Cruz Machado no estado do Paraná, suas perspectivas de desenvolvimento local e geração de renda no sistema de agricultura familiar. A metodologia utilizada foi a pesquisa bibliográfica e consulta on line nos principais órgão e secretárias, mais o trabalho de campo com a averiguação de algumas propriedades rurais do município de Cruz Machado. Nos sistemas de agricul...

  7. Andanças póstumas: Machado de Assis em espanhol

    Directory of Open Access Journals (Sweden)

    Carlos Espinosa Domínguez

    2010-12-01

    Full Text Available A pesar de que unánimemente se le considera uno de los grandes escritores del siglo xix, fuera del Brasil la obra de Machado de Assis no tiene la difusión y el reconocimiento que merece. En este trabajo se hace un recuento histórico de las traducciones al español de sus novelas y cuentos, se analiza la calidad de algunas de esas versiones y se reflexiona sobre las causas de la escasa presencia que su obra literaria tiene en los países de Hispanoamérica.

  8. ELIAS MACHADO DISCUTE A FORMAÇÃO DO DOCENTE E DO ESTUDANTE DE JORNALISMO NA CONTEMPORANEIDADE

    Directory of Open Access Journals (Sweden)

    Marco Antônio Gehlen

    2017-05-01

    Full Text Available Doutor em Jornalismo pela Universidade Autônoma de Barcelona (Espanha, professor da Universidade Federal de Santa Catarina(UFSC e coordenador do Laboratório de Pesquisa Aplicada em Jornalismo Digital, o jornalista Elias Machado é uma referência nacional quando o assunto é o ensino de Jornalismo. Consultor Ad Hoc (CAPES, (CNPq, (SBPJOR, (COMPÓS, (INTERCOM e (FNPJ, Machado tem vasta experiência nas áreas de Teorias do Jornalismo, Metodologias de Pesquisa, Jornalismo Digital e Impresso.  Nesta entrevista, ele discute a deficiências da educação na área em faculdades públicas e privadas e alerta: "Temos que garantir que o aluno fique menos tempo em sala de aula. Nós temos que racionalizar e integrar as disciplinas para que sobre mais tempo para pesquisa e extensão". Ele aproveita a conversa para debater, ainda, as implicações que as novas diretrizes do curso, discutidas e implementas em todas as universidades do país, podem acarretar à carreira, bem como os dilemas sobre prática e teoria, produção laboratorial e formação de professores, entre outras dicotomias que afligem quem trabalha com comunicação social, seja no mercado, na pesquisa ou na sala de aula. Além disso, Machado critica nesse espaço de reflexão, as pesquisas que fazem uma mera análise de dados e incentiva os estudos aplicados. " porque a crítica pela crítica não resolve o problema da demanda social". Assumidamente um pesquisador polêmico e provocador, justifica: "se eu estudei e me preparei foi para enfrentar os problemas. Não tem sentido eu chegar num lugar e dizer mais do mesmo, as pessoas não precisam ouvir mais do mesmo".

  9. Tribes of Men: John Joseph Mathews and Indian Internationalism

    Science.gov (United States)

    Lutenski, Emily

    2012-01-01

    In this article, the author discusses John Joseph Mathews and Indian internationalism. As an old man, Osage intellectual, writer, and historian, John Joseph Mathews recalled his expatriation from the United States during the 1920s. After growing up in Pawhuska, Oklahoma, seat of the Osage Nation, where he had been born in 1894 to a white mother…

  10. A EVOCAÇÃO DO ROMANCE E O ESPÍRITO SUSPEITOSO EM RESSURREIÇÃO (1872, DE MACHADO DE ASSIS

    Directory of Open Access Journals (Sweden)

    ROGÉRIO FERNANDES DOS SANTOS

    Full Text Available Resumo Pretende-se debater a gênese do romance de Machado de Assis e a reflexão sobre o gênero romanesco ficcionalizada em seu primeiro trabalho como romancista. Para tanto, analisaremos o personagem Félix, um dos protagonistas de Ressurreição (1872. Veremos que, ao dotar sua construção ficcional de um personagem que é, ele mesmo, súmula das características do gênero romance, Machado de Assis também está definindo o gênero com o qual irá se consagrar. Com isso, é possível aproximar o romance machadiano da tradição do romance autorreflexivo e apontar a visão problematizante que o autor tinha sobre o gênero.

  11. The lssue of Guilt in Oedipus and Joseph K.

    Directory of Open Access Journals (Sweden)

    Janez Vrečko

    2002-07-01

    Full Text Available This essay addresses hamartia in Oedipus and Joseph K., originally guilt without sin later turned in to guilt of sin, as well as freedom and fate, death and redemption. The tragedy Oedipus the King starts with the plague in Thebes, while The Trial starts with the arrest of Joseph K., both events leading to the source of »misfortune«; since the source of misfortune is external, the two protagonists are guilty without committing a crime. In both works Aristotle's concept of hamartia is understood as an objective »tragic flaw« as well as a subjective decision taken by the hero. Since »guiltiness invites judgment«, both Oedipus and Joseph K. choose to flee in a »Wrong direction«, which leads to the fulfilment of the prophecy and to a verdict respectively. They misunderstand the objective hamartia and transform their guilt without sin in to the guilt of sin. But Oedipus' uncovering of his own past once the prophecy is fulfilled leads him to a theophanic death, while Joseph's recognition that his life has come to ruin leads to a bestial death. Iocasta and several female characters in The Trial attempt to thrust both men back in to the arena of objective hamartia, to restore them to the state of guilt without crime, but they fail. They do succeed, however, in leading the heroes to anagnorisis. This recognition enables Oedipus to evince his sense of responsibility by carrying out his self-punishment. Joseph's recognition, by contrast, includes neither responsibility nor self-punishment. The scene with Titorelli shows that Joseph's trial can only take place between two extremes -justice and manhunt - and as such it has parallels with the Chorus song following the scene with Oedipus and Teiresias. Moreover, it has a connection with the chapter taking place in the Cathedral, since the protagonists of each scene are identified at this point and their destinies linked to their names. On another level this scene reveals a similarity between the Sphinx

  12. Joseph Hooker: a philosophical botanist

    Indian Academy of Sciences (India)

    2008-04-24

    Apr 24, 2008 ... The nineteenth-century British botanist, Joseph Dalton Hooker, was one of the people whose career became a model for that of the modern, professional scientist. However, he preferred to refer to himself as a philosophical botanist, rather than a professional. This paper explores the reasons for this choice, ...

  13. story from the joseph narrative

    African Journals Online (AJOL)

    The story of Judah within the longer Joseph story (Genesis 37-50) provides an apt place for .... from the center, to honor all humans with absolute justice, equity, respect; to refrain ..... they were simply general behavior types with no relation to me (too abstract) ... the Bible and extract theology and then replicate it into theory.

  14. What do Flaubert, Dostoevsky and Machado de Assis have in common with neurology?

    Science.gov (United States)

    Vitturi, Bruno Kusznir; Sanvito, Wilson Luiz

    2017-12-01

    The Frenchman Gustave Flaubert, the Russian Fyodor Dostoevsky and the Brazilian Machado de Assis are known for their immeasurable contributions to literature. However, what most people do not know is that all three authors suffered from epilepsy and were affected by their neurological condition in different ways. We offer a short description of how epilepsy influenced their lives, how they dealt with it and how their neurological condition was present in their novels and correspondence. Their lives are excellent examples of how intimately neurology can be entwined in art and history, and provide an important perspective on patients with epilepsy.

  15. A Tribute to Joseph M. Lookofsky

    DEFF Research Database (Denmark)

    of Law, 1971). He became a member of the New York State Bar and started his professional career as an attorney for the United Artists Corporation, specializing in contract law and copyright law. In 1973 he married a Danish woman, Vibeke, and moved to Denmark. He then took a Danish law degree (cand......This book is a tribute to Professor Joseph M. Lookofsky, honoring his work as an internationally respected scholar within the areas of private law, comparative law and private international law. It contains contributions from a wide range of respected scholars and colleagues from around the globe...... on topics like the United Nations Convention on the International Sale of Goods (the CISG), Arbitration and Private International Law. Joseph M. Lookofsky was born in in 1945 in New York, USA, where he studied economics (B.A. Economics, Lehigh University, 1967) and law (J.D., New York University School...

  16. A recepção de Machado de Assis nos Estados Unidos durante as décadas de 1950 e 1960

    Directory of Open Access Journals (Sweden)

    Earl Fitz

    Full Text Available Na literatura, a questão da recepção é extremamente complexa e, ao mesmo tempo, essencial, sobretudo se quisermos compreender melhor o impacto que tem em outra uma cultura literária pouco conhecida. Neste artigo, estudo a recepção de Machado de Assis nos Estados Unidos durante os anos 1950, quando três de seus romances - Memórias póstumas de Brás Cubas, Dom Casmurro e Quincas Borba - apareceram pela primeira vez em tradução para o inglês. Também considero a recepção de Machado nos anos 1960, período do chamado "boom", quando o autor brasileiro, apesar de ter sido muito admirado pelo crítico e escritor norte-americano John Barth, não recebeu a aclamação geral que merecia.

  17. Green sea turtle age, growth, and population characteristics in St. Joseph Bay, Florida from 1998 to 2010 (NCEI Accession 0159273)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains morphology, sex ratio, body condition, disease status, age structure, and growth patterns of 448 green sea turtles cold stunned in St. Joseph...

  18. Where was Joseph Babinski born?

    Directory of Open Access Journals (Sweden)

    H A G Teive

    2011-01-01

    Full Text Available There is controversy in the neurological literature about where Joseph Babinski was born, including a myth propounded by various important authors that he was born in Lima, Peru. However, according to the most consistent biographical data, he was in fact born in Paris, France, and became a medical celebrity there and in Poland as well as around the world.

  19. What do Flaubert, Dostoevsky and Machado de Assis have in common with neurology?

    Directory of Open Access Journals (Sweden)

    Bruno Kusznir Vitturi

    Full Text Available ABSTRACT The Frenchman Gustave Flaubert, the Russian Fyodor Dostoevsky and the Brazilian Machado de Assis are known for their immeasurable contributions to literature. However, what most people do not know is that all three authors suffered from epilepsy and were affected by their neurological condition in different ways. We offer a short description of how epilepsy influenced their lives, how they dealt with it and how their neurological condition was present in their novels and correspondence. Their lives are excellent examples of how intimately neurology can be entwined in art and history, and provide an important perspective on patients with epilepsy.

  20. De la modernidad machadiana a las bases del modernismo brasileño: lectura de la crítica de Joaquim Maria Machado de Assis

    Directory of Open Access Journals (Sweden)

    Robinson Francisco Alvarado Vargas

    2014-11-01

    Full Text Available Este escrito interpreta la función y deber ser de la literatura y la crítica literaria en algunos artículos publicados por Machado de Assis durante la segunda mitad del siglo XIX. Tal búsqueda tiene como fin establecer un vínculo entre las nociones sobre lo literario, la crítica de Machado y algunas premisas literarias que alentaron el avance del modernismo brasileño. En el artículo se esbozan diferentes aspectos que permiten entrever la modernidad del pensamiento machadiano respecto a lo literario y se proponen puntos de contacto que supondrían la presencia del pensamiento del autor en las ideas y problemas discutidos por la vanguardia brasileña durante las primeras décadas del siglo XX.

  1. 75 FR 15430 - Chief Joseph Hatchery Program

    Science.gov (United States)

    2010-03-29

    ... production program and hatchery facilities. The National Oceanic and Atmospheric Administration's National... DEPARTMENT OF ENERGY Bonneville Power Administration Chief Joseph Hatchery Program AGENCY: Bonneville Power Administration (BPA), Department of Energy (DOE). ACTION: Notice of availability of Record...

  2. Verlossing: van Pelagius tot Joseph Smith

    Directory of Open Access Journals (Sweden)

    H.F. van Wyk

    2010-07-01

      During this time Joseph Smith started to seek the true church and founded the Mormon Church. Although his theology differs quite strongly from the Methodist Church in which he grew up, the core of the way of salvation is the same: man has free will in choosing his salvation.

  3. Interview: Joseph Agassi

    Directory of Open Access Journals (Sweden)

    Joseph Agassi

    2016-12-01

    Full Text Available Joseph Agassi is an Israeli scholar born in Jerusalem on May 7, 1927. He has many books and articles published contributing to the fields of logic, scientific method, foundations of sciences, epistemology and, most importantly for this Journal, in the historiography of science. He studied with Karl Popper, who was definitely his biggest influence. He taught around the world in different universities. He currently lives in Herzliya, Israel. For his important contribution to the historiography of science, we chose to open the first issue of this journal with this interview recognizing his importance for the field, as well as paying our homage to him.

  4. A Political Approach of the Popular Credit: Pierre-Joseph Proudhon and the mutual credit

    OpenAIRE

    Cyrille Ferraton; David Vallat

    2011-01-01

    Pierre-Joseph Proudhon’s ideas on credit and money have been considered to be not very relevant and above all unrealistic. However, they have known an uncommon posterity. They influenced Silvio Gesell who is John Maynard Keynes’s reference. This article analyses Pierre-Joseph Proudhon’s exchange bank plan. We show that Pierre- Joseph Proudhon’s ideas on credit and money are opened to criticism but require a reexamination because we can draw many lessons from them.

  5. Ethical Concern in Joseph Heller’s Catch-22

    Institute of Scientific and Technical Information of China (English)

    XIAN Yu-jing

    2015-01-01

    In Catch-22, Joseph Heller shows his ethical concern behind absurdity, which is manifested from his attitude toward individualism and utilitarianism, religious belief, sexual promiscuity, interpersonal relationship, etc.

  6. IN THE EARLY JOSEPH ALOIS JULIUS SCHUMPETER'S FOOTSTEPS - MARRIAGE, TRAGEDY AND EMIGRATION

    Directory of Open Access Journals (Sweden)

    J-U. Sandal

    2015-10-01

    Full Text Available At the age of 42 Joseph Alois Schumpeter married the 20 years younger Anna (“Annie” Josefina Reisinger. Joseph Schumpeter is looking forward to being a father, and the couple have a child, Joseph, but both Annie and the baby dies during confinement. The tragedy is a fact, and Schumpeter loses the joy of scientific creativity and concentration. His existence is concurrently burdened by private financial problems. He holds fast to his creative youth work, Theorie der wirtschaftlichen Entwicklung, which is a companion through life and the foundation stone of modern entrepreneurial research worldwide. The article analyzes the important events in Schumpeter’s life and its importance to scientific development in economic theory.

  7. Estratégias de leitura da tradição literária brasileira na crítica de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Andréa Sirihal Werkema

    Full Text Available Neste artigo, são discutidas as estratégias utilizadas por Machado de Assis, em seu célebre ensaio "Instinto de nacionalidade" (1873, para não apenas inserir a sua própria produção literária no quadro da literatura brasileira de então, mas também para lançar um olhar sobre as futuras possibilidades, a partir daquele momento, de produção de uma literatura não pautada pelo crivo do nacionalismo literário no Brasil. Ou seja, o ensaio de Machado lançaria, para nós, leitores a posteriori, uma luz especial sobre a futura obra ficcional do autor, já que ele proporia um princípio de indeterminação do índice diferenciador dos textos da literatura brasileira, índice até então associado aos traços brasileiristas aí encontrados.

  8. Machado de Assis, da troca de mãos às coisas perdidas

    Directory of Open Access Journals (Sweden)

    Ana Luiza Andrade

    2000-03-01

    Full Text Available As crônicas de Machado de Assis funcionam esteticamente como alegorias modernas, no sentido de Walter Benjamin, de transição entre os resíduos de um modo de produção doméstico e manufaturado, para o industrial capitalista. Na crítica a ambos os modos, a crônica, como memória e esquecimento, recicla um corpo literário, orgânico, fantasmático,através das novas técnicas; ambiguamente progressista e antiprogressista. A dialética de seus movimentos e formas fragmentárias representa-se auto-consciente em seus hibridismos, através do desmembramento de um corpo cultural.

  9. May Joseph,Fluid New York: Cosmopolitan Urbanism and the Green Imagination

    OpenAIRE

    Marche, Guillaume

    2015-01-01

    In Fluid New York: Cosmopolitan Urbanism and the Green Imagination, May Joseph, a social science and cultural studies scholar, explores the history, experience, representations, and political implications of New York City’s relation to its natural environment, especially its aquatic surroundings –be they rivers, harbor or ocean. Of particular interest to Joseph, and the reader, is New York’s status as an archipelagic metropolis. While the book does not purport to provide a straightforward his...

  10. Poderosa ignorancia: celos y pretensión de verdad en Dom Casmurro de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Rubén A. Sánchez-Godoy

    2014-01-01

    Full Text Available Este ensayo explora cómo las sospechas no comprobadas del protagonista de Dom Casmurro se articulan en un monólogo que pretende probar la infidelidad de su amada. Con base en el concepto de ideología de Žižek, proponemos que esta articulación es posible a partir de la construcción de una prueba que permite al narrador producir a su amada como objeto de deseo ambiguo, fascinante y poco confiable a la vez. Al reconstruir literariamente esta prueba, que convierte la incertidumbre y la sospecha en formas de empoderamiento epistemológico y moral, Machado expone e ironiza una perspectiva masculina que busca proteger privilegios de género en una sociedad con creciente movilidad femenina. This essay explores the way in which the unproven suspicions of the main character of Dom Casmurro become a monologue that aims to prove the infidelity of his beloved. Using Žižek’s concept of ideology, I propose that this monologue is possible on the basis of the elaboration of an argument that allows to the narrator to produce his object of desire as an ambiguous one, fascinating and unreliable at the same time. Through the literary reconstruction of this argument, that transforms incertitude and suspicion in possibilities of epistemological and moral empowering, Machado discusses and ironizes a masculine perspective that tries to maintain its gender related privileges in a society with increasing feminine mobility.

  11. Biblisch-koranische Figuren – feminin: Jesus, Joseph and Job Characters from the Bible and the Quran—Feminine: Jesus, Joseph and Job

    Directory of Open Access Journals (Sweden)

    Barbara Winckler

    2003-07-01

    Full Text Available Jesus, Joseph and Job stellt drei Texte aus der Feder zeitgenössischer libanesischer Autorinnen vor, die auf unterschiedliche Weise die Geschichten religiöser Figuren neu schreiben, und diskutiert sie im Hinblick auf ihr subversives Potential für gesellschaftlichen Wandel. Dazu werden in der Analyse neben der Intertextualität Konzepte genderorientierter und postkolonialer Ansätze wie métissage und borderlands herangezogen.In Jesus, Joseph and Job Hartman introduces three texts, written by contemporary Lebanese women authors who re-write the history of religious characters, and discusses these texts with respect to their subversive potential for societal change. In her analysis, Hartman does not only use intertextuality, but also gender-informed and post-colonial approaches such as, métissage and border spaces.

  12. Ludwig Boltzmann, Albert Einstein and Franz Joseph

    International Nuclear Information System (INIS)

    Broda, E.

    1983-01-01

    Under the Emperor Francis Joseph (1848-1916) the natural sciences were less weIl supported in Austria than in other countries of Europe. This is explained by the fact that the German speaking middle classes accepted the preeminence of the feudal forces with their antiscientific attitude. The reason for this readiness to subordination was that those middle classes feIt threatened in their relatively favourable situation by Slavs and Latins. Francis Joseph was the typical representative of the aristocracy. Personally, he did his duty conscientiously and was not corrupt, but progressive ideas and scientific thought were alien to him. From his desk he treated Boltzmann benevolently, but he had no wish to meet personally the greatest mind of the Empire or in any respect to ask his views. Another famous subject of the Emperor, Albert Einstein, was apparently ignored altogether. The structural weakness of Austria, due to the national problems, led to immobilism in her scientific life, but also, up to a point, to tolerance. The impression of Victor Adler on Einstein is considered in this historical context. (author) [de

  13. MODERNIDADE E MODA EM ESAÚ E JACÓ, DE MACHADO DE ASSIS

    Directory of Open Access Journals (Sweden)

    GEANNETI TAVARES SALOMON

    Full Text Available Resumo Este estudo propõe uma análise crítica e literária sobre a modernidade e a moda presentes na obra Esaú e Jacó, de Machado de Assis. Procuro refletir sobre a forma com que o escritor se apropria de realidades sociais cotidianas, relativas à modernidade de seu tempo e à moda, e as imprime nas estratégias de criação literária por meio de fatos reais entrelaçados às suas personagens, criando no espaço ficcional traços marcadamente relevantes para se observarem essas realidades. O pano de fundo da narrativa é o Rio de Janeiro do século XIX, momento em que ocorrem a crise do Império, a abolição da escravatura e o início da República. A obra permite perceber as relações sociais e profissionais masculinas, bem como o posicionamento da mulher nessa sociedade.

  14. The great neurosis of Dr. Joseph Gerard.

    Science.gov (United States)

    Lefrère, Jean-Jacques; Rouillon, Frédéric

    2013-01-01

    The Great Neurosis, of Dr. Joseph Gerard, was published in 1889 in Paris. The book, intended for the general public, shows the different varieties of neuroses through picturesque and instructive examples. Its scientific and medical value is poor, but provides us with the various meanings of the word 'neurosis' in the late nineteenth century. Copyright © 2013 S. Karger AG, Basel.

  15. Joseph Smith's tritheism : the prophet's theology in context, critiqued from a Nicene perspective / Keith Dayton Hartman II

    OpenAIRE

    Hartman, Keith Dayton

    2013-01-01

    Joseph Smith is one of the most enigmatic figures in American religious history. From the details of his life story to the eventual formation of his own church, much has been written on the legacy of Joseph Smith. However, there are still numerous areas of Smith’s life and thought that demand further engagement, especially from a Nicene perspective. The purpose of the present research is to substantively add to scholarly knowledge regarding Joseph Smith. In contradistinction...

  16. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human [alpha]-ketoglutarate dehydrogenase complex

    Energy Technology Data Exchange (ETDEWEB)

    Ali, G.; Cai, Xingang; Sheu, Kwan-Fu R.; Blass, J.P. (Cornell Univ. Medical College, White Plains, NY (United States)); Wasco, W.; Gaston, S.M.; Tanzi, R.E.; Cooper, A.J.L.; Gusella, J.F. (Massachusetts General Hospital, Charleston, MA (United States)); Szabo, P. (Cornell Univ. Medical College, New York, NY (United States))

    1994-03-01

    The authors have isolated and sequenced cDNAs representing the full-length (2987-bp) gene for dihydrolipoyl succinyltransferase (E2k component) of the human [alpha]-ketoglutarate dehydrogenase complex (KHDHC) from a human fetal brain cDNA library. The E2k cDNA was mapped to human chromosome 14 using a somatic cell hybrid panel, and more precisely to band 14q24.3 by in situ hybridization. This cDNA also cross-hybridized to an apparent E2k pseudogene on chromosome 1p31. Northern analysis revealed the E2k gene to be ubiquitously expressed in peripheral tissues and brain. Interestingly, chromosome 14q24.3 has recently been reported to contain gene defects for an early-onset form of familial Alzheimer's disease and for Machado-Joseph disease. Future studies will be necessary to determine whether the E2K gene plays a role in either of these two disorders.

  17. Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."

    Science.gov (United States)

    Thomson, Karen M.

    Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl…

  18. 77 FR 61657 - Indiana Northeastern Railroad Company-Abandonment Exemption-In Branch and St. Joseph Counties, MI

    Science.gov (United States)

    2012-10-10

    ... Northeastern Railroad Company--Abandonment Exemption--In Branch and St. Joseph Counties, MI Indiana... Branch County, Mich., and milepost 100.69 near Sturgis in St. Joseph County, Mich. (the Line). The Line... .'' Decided: October 2, 2012. By the Board, Rachel D. Campbell, Director, Office of Proceedings. Derrick A...

  19. Machado de Assis e a tradição dos comediantes estoicos

    Directory of Open Access Journals (Sweden)

    Daniela Soares Portela

    Full Text Available Hugh Kenner (2011 considera que Flaubert seria a matriz dos escritores considerados como "comediantes estoicos", seguido por Joyce e Beckett. Esse termo definiria aqueles escritores que percebem a literatura como um sistema fechado de signos, em que as 26 letras do alfabeto e suas possibilidades comutativas, assim como os lugares adequados dos diversos atos de falas a situações específicas de comunicação, são os recursos que permitem ao escritor a criação de uma técnica que diferencia as possibilidades da comunicação escrita das práticas de oitiva. Ao seguir essa tradição, Machado de Assis desqualifica toda uma herança literária, rompe com a ilusão do projeto de totalidade da estética realista queirosiana e denuncia o aspecto arbitrário do signo linguístico e toda a matéria empírica representada por ele.

  20. Using Joseph Campbell to Improve Students' Response to Literature.

    Science.gov (United States)

    Barnum, Carol M.

    1992-01-01

    Shows how teachers can use the videotapes and writings of Joseph Campbell to help students see patterns in literature and respond personally to it. Presents Campbell's explanation of the monomyth of the hero's journey, and discusses three works in which the pattern is present. (SR)

  1. reflection on the theology of joseph ratzinger (pope benedict xvi)

    African Journals Online (AJOL)

    the Faith which issued, in 1985, a Notification on his book, Church, Charism and Power (1981), signed by Joseph ... Ratzinger's doctoral studies in the ecclesiology of Augustine and ...... Harvard Divinity Bulletin (autumn):56-62. Gutierrez, G.

  2. Histomorphometric analysis of osteopenia associated with endemic osteoarthritis (Mseleni joint disease).

    Science.gov (United States)

    Schnitzler, C M; Pieczkowski, W M; Fredlund, V; Mesquita, J M; Sweet, M B; Smit, A E

    1988-01-01

    Mseleni Joint Disease (MJD), a polyarticular osteoarthritis of uncertain etiology is endemic among the Tonga-Zulu tribe. The traditional diet is deficient in calcium, and palm wine (2-4% alcohol) is drunk widely. Patients with MJD are reported to be more osteopenic than those without. Iliac bone biopsies of 19 arthritic patients were examined by routine histomorphometry and revealed decreased trabecular bone volume (p less than 0.0005), increased resorption surfaces (p less than 0.01), decreased bone formation rate at the BMU (p less than 0.01) level and increased mineralization lag time (p less than 0.01). Six of the 19 patients (31.6%) had features of osteomalacia and six (31.6%) signs of osteoblast failure. The most likely cause of the bone disorder is calcium deficiency, but inanition, inactivity and alcohol abuse may have contributed. Although the joint disorder may have contributed to the bone disorder, the converse is unlikely the case.

  3. Spinocerebellar ataxias Ataxias espinocerebelares

    Directory of Open Access Journals (Sweden)

    Hélio A.G. Teive

    2009-12-01

    Full Text Available Spinocerebellar ataxias (SCAs constitute a heterogeneous group of neurodegenerative diseases characterized by progressive cerebellar ataxia in association with some or all of the following conditions: ophthalmoplegia, pyramidal signs, movement disorders, pigmentary retinopathy, peripheral neuropathy, cognitive dysfunction and dementia. OBJECTIVE: To carry out a clinical and genetic review of the main types of SCA. METHOD: The review was based on a search of the PUBMED and OMIM databases. RESULTS: Thirty types of SCAs are currently known, and 16 genes associated with the disease have been identified. The most common types are SCA type 3, or Machado-Joseph disease, SCA type 10 and SCA types 7, 2, 1 and 6. SCAs are genotypically and phenotypically very heterogeneous. A clinical algorithm can be used to distinguish between the different types of SCAs. CONCLUSIONS: Detailed clinical neurological examination of SCA patients can be of great help when assessing them, and the information thus gained can be used in an algorithm to screen patients before molecular tests to investigate the correct etiology of the disease are requested.As ataxias espinocerebelares (AECs compreendem um grupo heterogeneo de enfermidades neurodegenerativas, que se caracterizam pela presença de ataxia cerebelar progressiva, associada de forma variada com oftalmoplegia, sinais piramidais, distúrbios do movimento, retinopatia pigmentar, neuropatia periférica, disfunção cognitiva e demência. OBJETIVO: Realizar uma revisão clínico-genética dos principais tipos de AECs. MÉTODO: A revisão foi realizada através da pesquisa pelo sistema do PUBMED e do OMIM. RESULTADOS: Na atualidade existem cerca de 30 tipos de AECs, com a descoberta de 16 genes. Os tipos mais comuns são a AEC tipo 3, ou doença de Machado-Joseph, a AEC tipo 10, e as AECs tipo 7, 2 1, e 6. As AECs apresentam grande heterogeneidade genotípica e fenotípica. Pode-se utilizar um algoritmo clínico para a

  4. CDC's 29th Annual Joseph W. Mountin Lecture

    Centers for Disease Control (CDC) Podcasts

    In this podcast, William H. Foege, MD, MPH delivers the 29th Annual Joseph W. Mountin Lecture. Dr. Foege was a key leader in the smallpox effort and worked as an epidemiologist in the successful eradication campaign in the 1970s. Dr. Foege became chief of the Smallpox Eradication Program at CDC, and was appointed director of CDC in 1977.

  5. Flawed foundations of associationism? Comments on Machado and Silva (2007).

    Science.gov (United States)

    Gallistel, C R

    2007-10-01

    A. Machado and F. J. Silva have spotted an important conceptual problem in scalar expectancy theory's account of the 2-standard-interval time-left experiment. C. R. Gallistel and J. Gibbon (2000) were aware of it but did not discuss it for historical and sociological reasons, owned up to in this article. A problem of broader significance for psychology, cognitive science, neuroscience, and the philosophy of mind concerns the closely related concepts of a trial and of temporal pairing, which are foundational in associative theories of learning and memory. Association formation is assumed to depend on the temporal pairing of the to-be-associated events. In modeling it, theorists have assumed continuous time to be decomposable into trials. But life is not composed of trials, and attempts to specify the conditions under which two events may be regarded as temporally paired have never succeeded. Thus, associative theories of learning and memory are built on conceptual sand. Undeterred, neuroscientists have defined the neurobiology-of-memory problem as the problem of determining the cellular and molecular mechanism of association formation, and connectionist modelers have made it a cornerstone of their efforts. More conceptual analysis is indeed needed. Copyright 2007 APA, all rights reserved.

  6. HÉNAUX, Victor. De l’amour des femmes pour les sots / Queda que as mulheres têm para os tolos. Tradução de Machado de Assis. Edição Bilíngue. Organização: Ana Cláudia Suriani da Silva e Eliane Fernanda Cunha Ferreira. Campinas: Editora Unicamp. 2008.

    Directory of Open Access Journals (Sweden)

    Kall Lyws Barroso Sales

    2015-06-01

    Full Text Available Em 2008, em comemoração ao centenário de Machado, as professoras Ana Cláudia Suriani da Silva e Eliane Fernanda Cunha Ferreira retomam as discussões sobre autoria, plágio e tradução, propondo uma edição bilíngue na qual cotejam a obra de Hénaux, De l'amour des femmes pour les sots de 1858 e a tradução de Machado Queda que as mulheres têm para os tolos de 1861. Assim, esta resenha analisa a tradução de Machado de Assis, cuja autoria da obra, durante muito tempo, foi atríbuida ao escritor brasileiro.

  7. Franz Joseph Gall and music: The faculty and the bump

    NARCIS (Netherlands)

    Eling, P.A.T.M.; Finger, S.; Whitaker, H.A.

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can

  8. A study based on trace elements of differentiated metabasic rocks from the Machado-MG region

    International Nuclear Information System (INIS)

    Choudhuri, A.; Carvalho, S.G. de.

    1983-01-01

    Large metabasic intrusive bodies occur in the Precambrian gneiss-migmatite basement around Poco Fundo - Campestre - Machado Triangle, south Minas Gerais. Separate occurrences consisting in each case of pyroxenite, metagabbro and amphibolite seem to be related to each other as is evident from their mineralogy, texture and trends of trace element concentration when plotted against their mg number (Mg/MgO + FeO mol.). Furthermore, their trace elements indicate that these rocks belong to a differentiated sequence resulting from separation of pyroxenes in situ. In spite of their high large ion lithophile element contents comparable to calc-alcaline rocks, the metabasic rocks show close resemblance to present-day mid-ocean ridge basalts when these are plotted in relevant variation diagrams. The tectonic implication of the observations is, however, not yet clear. (Author) [pt

  9. CERAMBYCIDAE BEETLES ASSOCIATED TO Eucalyptus spp. IN THE MUNICIPALITY OF PINHEIRO MACHADO, RS

    Directory of Open Access Journals (Sweden)

    Oderlei Bernardi

    2011-03-01

    Full Text Available The objective of this study was to collect, identify and carry out a faunistic characterization of Cerambycidae occurring in a forest of Eucalyptus spp., on São Manoel farm, in the municipality of Pinheiro Machado, RS. In the period from February 2006 to October 2007, collections of insects were performed every 15 days, with three ethanol traps. After selection procedures, the Cerambycidae were identified based on entomological collections and specialized literature. We collected 692 insects, distributed among 29 genera and 40 species. The most abundant species were Acanthoderes jaspidea, Chlorida costata, Compsocerus barbicornis, Eburodacrys sp., Eurysthea hirta, Neoclytus curvatus and Nyssodrysina lignaria, which represented 81.17% of the total individuals. Cerambycidae were collected during practically the entire sampling period, but the largest number at a single collection occurred in the month of December. Several species demonstrate potential for damaging Eucalyptus spp., of which Neoclytus curvatus deserves the most attention, because it represented almost half of the insects collected.

  10. MACHADO DE ASSIS E A MÚSICA: UMA ANÁLISE DO CONTO “TRIO EM LÁ MENOR”

    Directory of Open Access Journals (Sweden)

    Maria Inês Werlang Ghisleni

    2008-11-01

    Full Text Available No conto “Trio em lá menor”, Machado de Assis utiliza elementos da teoria musical para designar, a partir do título, cada uma de suas partes: I Adagio cantabile, II Allegro ma non troppo, III Allegro appassionato e IV Minueto, relacionando-as ao próprio enredo do conto. Percebe-se ainda o intuito do autor de traduzir o que se passa no interior das personagens através da música. Maria Regina, protagonista da história, amava dois homens ao mesmo tempo: Maciel com 27 anos e Miranda de 50 anos. Desse cenário surge o triângulo amoroso. Na seqüência dos relatos, há a correspondência dos significados musicais com os acontecimentos, em cada uma das partes da narrativa. Há a presença permanente da sonata, como fundo musical durante todo o texto. Maria Regina não conseguia escolher entre os dois pretendentes porque ambos não a satisfaziam individualmente. Amava um ser ficcional que continha as características positivas de ambos. A indecisão de Maria Regina aborreceu aos dois homens até que perderam as esperanças e desistiram. Só, fitando o céu em busca de uma estrela dupla, Maria Regina incapaz de alcançar o astro esplêndido olha para dentro de si mesma e descobre duas grandes luzes. Em sonho, ouve que sua pena seria oscilar por toda a eternidade entre dois astros incompletos. Sua vida, uma eterna busca pela perfeição, seria sempre acompanhada do som da sonata do absoluto. Na medida em que a leitura transcorre emerge dos eventos e do conto todo um melhor entendimento do sentido da narrativa de Machado de Assis relacionado ao conhecimento da música.

  11. Cien años de Soledades. Galerías. Otros poemas: Presente y pasado en Antonio Machado

    Directory of Open Access Journals (Sweden)

    Rodríguez García, José María

    2009-06-01

    Full Text Available Machado was extremely interested in the use of non-linear temporal sequences, which explains in part his emphasis à la Bergson on repetition, the intellectual paradoxes arising from the leaps backwards and forwards in the subject’s consciousness, and even his view of the past as a creation in the present using the subjective materials of memory. In this essay I adopt advisedly Ortega’s concept of the «dialectical series» to connect the critique of biographical time found in Soledades, which revolves around the binomial «history»/«legend», with the poet’s preference for the time of performative enunciation over the time of the anecdote’s content. To this end, I will discuss in detail a handful of poems drawn form the 1902-1903 and 1907 editions of Soledades.Machado tuvo una fijación con las secuencias temporales alternativas al discurrir lineal, lo cual explica su énfasis en la repetición, las paradojas intelectuales resultantes de los saltos adelante y atrás en la conciencia, e incluso la concepción del pasado como creación memorística del presente, un poco a la manera de Henri Bergson. En el presente trabajo, conecto la crítica del tiempo biográfico en el poemario Soledades con la «serie dialéctica» (uso este concepto en su lato sentido orteguiano construida a partir del binomio «historia»/ «leyenda» en el mismo libro, y con la preferencia del autor por el tiempo de la enunciación improvisa (performance sobre el tiempo del enunciado anecdótico. En este menester comentaré en detalle un ramillete de poemas del vate sevillano entresacados de las ediciones de Soledades de 1902-1903 y 1907.

  12. USA saadik loodab võita eestlaste poolehoiu / Joseph M. DeThomas

    Index Scriptorium Estoniae

    DeThomas, Joseph M.

    2003-01-01

    USA suursaadik Eestis Joseph DeThomas vastab on-line intervjuus Eesti Päevalehe lugejate küsimustele Iraagi ründamise, USA ja Euroopa vahelise lõhe, USA Eesti saatkonna võimaliku ümberkolimise kohta

  13. IS MACHADO DE ASSIS A HISTORIAN? THE CHRONICLES “A SEMANA” AND MEMORIES OF SLAVERY, REPUBLIC AND CANUDOS

    Directory of Open Access Journals (Sweden)

    Osmar Oliva

    2012-12-01

    Full Text Available Born as a feuilleton, the chronicle of the nineteenth century approached the most diverse topics, from trivial to serious from unimportant to more serious events. For a long time, Machado de Assis was misunderstood by his readers and a large number of reviewers dedicated to his work, because they had difficulty to find political engagement or concern in the production of this author. The Chronicles of “A Semana”, however, reveal not only an intense reflection on the important events of the nineteenth-century Brazil but also the development of narrative construction techniques like a mosaic, which thinking appears fragmented in various subjects which deal with the writer.

  14. Water quality and discharge data for St. Joseph Bay, Florida, 1997-98

    Science.gov (United States)

    Berndt, M.P.; Franklin, M.A.

    1999-01-01

    Historical data were compiled on water quality and water levels for the St. Joseph Bay area to assess quality of possible sources of land-derived water into the Bay. Ground-water quality data were compiled from Florida Department of Environmental Protection and surface-water quality data were compiled from U.S.Geological Survey files. Water-quality and water-level data were measured during two sample collection periods in October 1997 and March 1998 to determine water-quality and discharge rates in St. Joseph Bay under two sets of flow conditions. Measurements in the Bay included water level, temperature, pH, specific conductance, dissolved oxygen, and turbidity. Median pH in water from the surficial, intermediate and Floridan aquifer systems ranged from 4.8 to 7.8, and median specific conductance values were less than 500 microsiemens per centimeter. Median nutrient concentrations-- nitrate plus nitrite, ammonia and phosphorus--in the three aquifers were less than 0.5 milligrams per liter. The median pH was 7.0 and the median specific conductance was 81 microsiemens per centimeter for two samples from the Chipola River distribution canal. Water level data were obtained for several wells near St. Joseph Bay but only two wells yielded sufficient data to plot hydrographs. Measurements in St. Joseph Bay during the October and March collection periods were similar for pH and turbidity but differed for temperature, specific conductance and dissolved oxygen. The median temperature was 20.6 degrees Celsius in October and 15.4 degrees Celsius in March, median specific conductance was 39,500 microsiemens per centimeter in October and 43,300 microsiemens per centimeter in March, and median dissolved oxygen was 7.6 milligrams per liter in October and 8.3 milligrams per liter in March. The range in water levels over a tidal cycle in St. Joseph Bay on October 29, 1997 was about 1 foot. During a 24-hour tidal cycle on October 29, 1997, estimated hourly discharge varied from

  15. Ciências possíveis em Machado de Assis: teatro e ciência na educação científica Possible sciences in Machado de Assis: theatre and science in scientific education

    Directory of Open Access Journals (Sweden)

    Thelma Lopes Carlos Gardair

    2009-01-01

    Full Text Available Este estudo busca compreender como a relação entre teatro e ciência pode ser profícua na educação em ciências, a partir de atividade desenvolvida no "Ciência em Cena", área do Museu da Vida, Fundação Oswaldo Cruz/RJ. A atividade consiste na apresentação da peça "Lição de Botânica", de Machado de Assis, seguida de debate e exibição de cd-rom. Neste artigo foi analisado o primeiro semestre da temporada de 2007, que reuniu 1.827 pessoas. As 171 perguntas elaboradas durante os debates realizados após trinta espetáculos, foram registradas por escrito e interpretadas com base em critérios metodológicos da "análise de conteúdo". O exame dos dados permite discutir a interface entre processos de criação artística e educação científica. Tal discussão está ancorada na perspectiva problematizadora da educação segundo Freire e no entendimento, tal qual Maturana, da educação como um espaço dialógico de convivência, um lugar de perene criação/recriação da vida.This paper investigates how the relationship between art and science can be productive in science education, from an activity developed in "Science on Scene", a visitor area of the Museum of Life, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. The activity consists of the presentation of the play "Lessons of Botany", by Machado de Assis, followed by debate and the playing of a CD-rom. In this paper the first semester of the 2007 season was analyzed, including 1.827 spectators. The 171 questions elaborated during the debates carried through after thirty performances, had been registered in writing and interpreted on the basis of "Content Analysis". Examination of the data stimulates the discussion about the interface between the processes of artistic creation and scientific education. This discussion is based within a Freire critical perspective of education, and is seen as a dialogic space, a place of permanent creation/recreation of life.

  16. Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis

    Science.gov (United States)

    Matthews, Michael R.

    2009-01-01

    This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of…

  17. HÉNAUX, Victor. De l’amour des femmes pour les sots / Queda que as mulheres têm para os tolos. Tradução de Machado de Assis. Edição Bilíngue. Organização: Ana Cláudia Suriani da Silva e Eliane Fernanda Cunha Ferreira. Campinas: Editora Unicamp. 2008.

    Directory of Open Access Journals (Sweden)

    Kall Lyws Barroso Sales

    2014-11-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2015v35n1p313   Em 2008, em comemoração ao centenário de Machado, as professoras Ana Cláudia Suriani da Silva e Eliane Fernanda Cunha Ferreira retomam as discussões sobre autoria, plágio e tradução, propondo uma edição bilíngue na qual cotejam a obra de Hénaux, De l'amour des femmes pour les sots de 1858 e a tradução de Machado Queda que as mulheres têm para os tolos de 1861. Assim, esta resenha analisa a tradução de Machado de Assis, cuja autoria da obra, durante muito tempo, foi atríbuida ao escritor brasileiro.

  18. Pseudogene of dihydrolipoyl succinyltransferase (E2k) found by PCR amplification and direct sequencing of rodent-human cell hybrid DNAs

    Energy Technology Data Exchange (ETDEWEB)

    Cai, X.; Ali, G.; Blass, J.P. [Cornell Univ. Medical College, White Plains, NY (United States); Szabo, P. [Cornell Univ. Medical College, New York, NY (United States); Tanzi, R.E. [Massachusetts General Hospital, Boston, MA (United States)

    1994-07-01

    Previous studies have indicated that the cDNA for the E2k component of the human {alpha}-ketoglutarate dehydrogenase complex (KGDHC) hybridized not only to a major locus on chromosome 14q24.3 in a region associated with familial Alzheimer`s disease and with Joseph-Machado disease, but also to another locus on chromosome 1p31. The authors now report that PCR of genomic DNA and direct sequencing indicated that the chromosome 1 locus is an intronless pseudogene. PCR of genomic DNA amplified E2k fragments from mouse-human cell hybrids containing human chromosome 1 DNA but not from hybrids containing human chromosome 14 DNA. The resulting amplicons were of comparable sizes to those when the cDNA was used to template. The direct sequencing of these amplicons confirmed the lack of introns and indicated a frame shift, which led to the presence of four termination codons early in the coding region. PCR followed by direct sequencing of the amplicons appears to be a convenient method for identifying intronless pseudogenes.

  19. Os imigrantes italianos em São Paulo, na perspectiva de Alcântara Machado

    Directory of Open Access Journals (Sweden)

    Vera Lúcia de Oliveira

    2004-12-01

    Full Text Available Il libro Brás, Bexiga e Barra Funda, di Alcântara Machado, pubblicato nel 1927, tratta della vit di alcuni quartieri poplari di San Paolo (indicati nel titolo dell´opera, obitari da immigranti italiani. Il narratore rappresenta questo universo - ora con simpatia ora con ironia - rivelando, in modo chiaro o tra le righe, gli sterotipi in voga in quel periodo sugli italiani arrivati da poco, che non conoscevano ancora la lingua e le tradizioni del Brasile, ma desideravano raggiungere rapidamente una posizione social ed economica elevata, per conquistare un posto nella nuova società. Nell´articolo si propone una lettura dello scontro fra gli immigranti e la società brasiliana, scontro filtrato nei racconti che presentano - con straordinaria vivacità - il quotidiano dei quartieri popolari di San Paolo, proprio nel momento in cui vari gruppi di immigranti stanno vivendo il processo di integrazione e assimilazione.

  20. Viaje terminado, viaje inevitable, viaje imposible: la superación literaria del viaje a Europa en Memorial de Aires de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Rubén A. Sánchez-Godoy

    2017-01-01

    Full Text Available Este ensayo propone una aproximación a Memorial de Aires de Machado de Assis (1908. Esta novela recoge las reflexiones que el consejero Aires, un diplomático retirado en Río de Janeiro, hace a propósito de una historia de amor entre dos jóvenes que, después de varias deliberaciones, deciden abandonar Brasil para vivir en Portugal en contra del deseo de sus protectores. El ensayo examina la relevancia de la abolición de la esclavitud en la decisión que toman los jóvenes y cómo ese evento produce una reconsideración tanto de las relaciones entre metrópoli y periferia como de las causas de la tristeza. This essay proposes an approach to Machado de Assis’ last novel, Counselor Aires’ Memorial (1908. In this novel, counselor Aires, a former Brazilian diplomat, narrates the story of a young couple that, after a long decision-making process, decides to move from Brazil to Portugal against the will of their protectors. The essay examines the relevance of the abolition of slavery in Brazil in 1888 for their decision to leave the country, and to what extent abolition promotes a new understanding of the relationship between metropolitan centers and periphery as well as a reflection about the causes of sadness.

  1. A Fourth Way : Joseph Ratzinger’s veluti si Deus daretur

    NARCIS (Netherlands)

    Ossewaarde-Lowtoo, Roshnee

    The rationale behind Joseph Ratzinger’s intriguing proposition to his «non-believing friends» to live as if God exists is here examined. It is argued that his wager makes sense when it is interpreted in the light of his commitment to the transcendent dignity of all humans. His proposition may enable

  2. Joseph and Michael Haydn in the Bohemian music archives. An anniversary tribute

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2012-01-01

    Roč. 20, č. 1 (2012), s. 117-126. ISBN 978-3-486-58949-8. ISSN 1865-5696 Institutional support: RVO:68378076 Keywords : Joseph Haydn * Michael Haydn * music archives Subject RIV: AL - Art, Architecture, Cultural Heritage

  3. Disease: H01478 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems. Minor...distributed worldwide. MJD is an autosomal dominant neurodegenerative disorder, involving predominantly the

  4. Recreating Religion: The Response to Joseph Smith’s Innovations in the Second Prophetic Generation of Mormonism

    OpenAIRE

    Blythe, Christopher James

    2011-01-01

    On June 27, 1844, Joseph Smith, the founder of The Church of Jesus Christ ofLatter-day Saints, was assassinated. In the wake of his death, a number of would-besuccessors emerged. Each of these leaders - part of what I call the second propheticgeneration - established a unique vision of Mormonism. In 1844, Mormonism was in the middle of a major shift in its character. JosephSmith’s death left numerous theological and practical questions unresolved. This thesis argues that, rather than merel...

  5. “Migrant Women Are Always Added”: In Conversation with Ebun Joseph Akpoveta

    Directory of Open Access Journals (Sweden)

    Asier Altuna-García de Salazar

    2017-03-01

    Ebun Joseph Akpoveta lives in Dublin with her beloved family. I would like to thank her for her patience and kindness in collaborating to expand and finalise the present written version of her interview through e-mail.

  6. JOSEPH M. JURAN - Human personality and his creation

    OpenAIRE

    Stefan Ragalie

    2004-01-01

    It is well-known the idea that the social welfare level of the nation, more precisely the daily quality life level of the country depend on the quality of goods and services realized and exported by its citizens. In this context, the concepts and principles introduced by Joseph M. Juran in the economic thinking and known as Juran Trilogy (this trilogy puts together the three major activities: the planning, control and improving of the quality) become important for the Romanian firms and offer...

  7. Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

    Science.gov (United States)

    2017-09-28

    ; Non Progressive Epilepsy and/or Ataxia With Myoclonus as a Major Feature; Spectrin-associated Autosomal Recessive Cerebellar Ataxia; Spasticity-ataxia-gait Anomalies Syndrome; Spastic Ataxia With Congenital Miosis; Spastic Ataxia - Corneal Dystrophy; Spastic Ataxia; Rare Hereditary Ataxia; Rare Ataxia; Recessive Mitochondrial Ataxia Syndrome; Progressive Epilepsy and/or Ataxia With Myoclonus as a Major Feature; Posterior Column Ataxia - Retinitis Pigmentosa; Post-Stroke Ataxia; Post-Head Injury Ataxia; Post Vaccination Ataxia; Polyneuropathy - Hearing Loss - Ataxia - Retinitis Pigmentosa - Cataract; Muscular Atrophy - Ataxia - Retinitis Pigmentosa - Diabetes Mellitus; Non-progressive Cerebellar Ataxia With Intellectual Disability; Non-hereditary Degenerative Ataxia; Paroxysmal Dystonic Choreathetosis With Episodic Ataxia and Spasticity; Olivopontocerebellar Atrophy - Deafness; NARP Syndrome; Myoclonus - Cerebellar Ataxia - Deafness; Multiple System Atrophy, Parkinsonian Type; Multiple System Atrophy, Cerebellar Type; Multiple System Atrophy; Maternally-inherited Leigh Syndrome; Machado-Joseph Disease Type 3; Machado-Joseph Disease Type 2; Machado-Joseph Disease Type 1; Lethal Ataxia With Deafness and Optic Atrophy; Leigh Syndrome; Leukoencephalopathy With Mild Cerebellar Ataxia and White Matter Edema; Leukoencephalopathy - Ataxia - Hypodontia - Hypomyelination; Leigh Syndrome With Nephrotic Syndrome; Leigh Syndrome With Leukodystrophy; Leigh Syndrome With Cardiomyopathy; Late-onset Ataxia With Dementia; Intellectual Disability-hyperkinetic Movement-truncal Ataxia Syndrome; Infection or Post Infection Ataxia; Infantile-onset Autosomal Recessive Nonprogressive Cerebellar Ataxia; Infantile Onset Spinocerebellar Ataxia; GAD Ataxia; Hereditary Episodic Ataxia; Gliadin/Gluten Ataxia; Friedreich Ataxia; Fragile X-associated Tremor/Ataxia Syndrome; Familial Paroxysmal Ataxia; Exposure to Medications Ataxia; Episodic Ataxia With Slurred Speech; Episodic Ataxia Unknown Type

  8. A Reading of Joseph Conrad's The Tale

    OpenAIRE

    Zadeh, Mohammad Reza Modarres

    2013-01-01

    The Tale is a short story by Joseph Conrad. Typical of a Conrad story it is set at sea. The sea is symbolic of the unconscious and this story may be read as a story of the unconscious. On the outside, it seems simple; a man tells a woman a tale of the commanding officer of a patrol ship who gives false directions to another ship and sends it to its doom. In between the lines of the seemingly simple plot, however, can be read another tale; one which speaks of a human sea deeper than the sea of...

  9. Resurrecting Democracies : Secularity Recast in Charles Taylor, Paul Valadier, and Joseph Ratzinger

    NARCIS (Netherlands)

    Ossewaarde-Lowtoo, Roshnee

    In this article, the alternative conception of secularity of Charles Taylor, Paul Valadier and Joseph Ratzinger (former Benedict XVI) is explored. A secularized society, which they take as an established condition, does not necessarily exclude religion, Christianity or Christian transcendence, in

  10. Vozes no conto de Machado de Assis sobre um incêndio em Montevidéu

    Directory of Open Access Journals (Sweden)

    Luiz Gonzaga Marchezan

    2015-07-01

    Full Text Available Na reflexão dialógica sobre a enunciação, Voloshinov enfatiza sua porção subentendida como aquela que é comum a um grupo social e que, portanto, não precisa ser explicitada. Dessa maneira, o autor observa a possibilidade de o enunciador, ao acrescentar, justapor, situações de memória no tempo e no espaço narrados, conjugar percepções acerca da existência em matéria de ficção; vinculá-las a entonações que estreitam ainda mais a interlocução entre as coisas vividas e o enunciado. Diante disso, analisamos, pelo ângulo dialógico, o conto Um incêndio, de Machado de Assis, motivado por notícia de um incêndio ocorrido em região portuária de Montevidéu, que lhe deu o engenheiro Abel Ferreira de Matos, que, por sua vez, ouvira do menino Manuel Bandeira.

  11. Carl Sagan and Joseph Shklovsky: Intelligent Life in the Universe

    Science.gov (United States)

    Kurt, Vladimir

    J. S. Shklovsky and Carl Sagan played an outstanding role in modern astronomy. Their names are well known not only to professional astronomers, but also to millions of educated people in many countries, which are interested in modern state of science research. Among these trends of modern science, which are difficult to define, are such problems, as the creation of Solar system, the origin of life on Earth, the evolution of living organisms on Earth from the simplest viruses to Homo Sapiens, the evolution of intelligence and technology. Finally, both outstanding scientists were deeply interested in the problem of SETI (Search Extraterrestrial Intelligence), i.e. search of extraterrestrial civilizations and methods of making contacts with them. And both scientists were high professionals in their fields. Joseph Shklovsky was a theoretical astronomer in all fields of modern astronomy (geophysics and physics of the upper atmosphere of the Earth, Sun and Solar Corona, Interplanetary Medium and Solar Wind, Interstellar Medium, Supernova and their remnants, the Galaxy and galaxies, Quasars and Cosmology). There is hardly a field in modern astrophysics (except perhaps the theory of the interior structure of stars), where Joseph Shklovsky has not l a bright stamp of his talent…

  12. Kaiser Franz Joseph I und die Serben 1848–1908

    Directory of Open Access Journals (Sweden)

    Wolfgang Rohrbach

    2017-02-01

    Full Text Available A century from death of Emperor Franz Joseph I (+21.11.1916 triggered a great number of publications about life and almost seven decades long reign of a popular monarch. As the political struggle between Russia, Prussia, Italy and Ottoman Empire are depicted with moderation, Serbia is described unidimensional, with an emphasis on the last decade of Emperors rule. In order to remedy this shortcoming, this contribution is focusing on a period between 1848 and 1908. Today we know much more about relations between Franz Joseph and King Milan Obrenović, as well as with dignitaries of Serbian Orthodox Church, and military, academic and artistic elite. It is, therefore, possible to refute entrenched notions about constant enmity and hostility between Austria and Serbia. In this work, an emphasis is put on cooperation between Austria and Serbia from 1848, when Serbs at Emperors request held a number of important political and military positions, whereas Serbian artists took part in the reconstruction of Imperial Vienna. The university of Vienna hosted the oldest institute for slavistic (1849, becoming, therefore, a crossroad of the cultural and social development of the Balkans.

  13. Internment and ministry: A dialogue with Joseph Kitagawa.

    Science.gov (United States)

    Moss, D M

    1993-09-01

    This dialogue presents a profile of the late Joseph Kitagawa-a renowned scholar of the history of religions (Religionswissenschaft). It focuses on comparative religion and philosophy, as well as several other important issues related to his distinguished career as an Episcopal priest and dean of the Divinity School of the University of Chicago. They are: his experience of American concentration camps during World War II; Christian atheism and new theological models; concepts of time in Oriental and Occidental faiths; depth-psychology and contemporary ministry; and Paul Tillich's significance for the pastoral counseling movement.

  14. Joseph M. Nyasani It is not only astronomers who have been ...

    African Journals Online (AJOL)

    THE UBICATION OF THE PHYSICAL UNIVERSE. Joseph M. Nyasani. It is not only astronomers who have been wondering about what lies beyond the planetary system and the extent of that reality in terms of the space it occupies. Philosophers have equally been baffled by this same question even though it may not be fair ...

  15. O letramento literário na formação de professores de Ensino Religioso - uma leitura do Mito do Dilúvio em um conto de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Araceli Sobreira Benevides

    2013-12-01

    Full Text Available This article takes as theoretical lenses to dialogical conception of language and theories of reading and literary literacy within the context of training teachers of Religious Education. The aim is to bring to the teacher’s education field litterary texts whose theme discusses Transcendent and religious phenomenon, in order to create moments of reading to understand the different ways in which religious discourses that are constituted by language. For this, we chose the short story "Na Arca – três capítulos inéditos do Genesis", wroten by Machado de Assis, relating it to the Myth of the Flood, in this sacred narratives to dialogue with the discourses that circulate in the literary’s field and epistemological knowledges from Sciences of Religion. The analysis shows how literature can re-upgrade myths to give new interpretations and questions, as does Machado de Assis, the positioning of the characters of the biblical narrative as subjects of everyday life, approaching the characteristics of the more mythical than real. We understand that subsidizes training future teachers of these insights can contribute to more efficient reading practices.

  16. Yue Joseph Wang named Grant A. Dove Professor of Electrical and Computer Engineering

    OpenAIRE

    Owczarski, Mark

    2009-01-01

    Yue Joseph Wang, professor of electrical and computer engineering in the College of Engineering at Virginia Tech, has been named the Grant A. Dove Professor of Electrical and Computer Engineering by the Virginia Tech Board of Visitors.

  17. The Vanadium Window with special reference to Joseph and James Flannery's contribution to the American steel and radium industries

    International Nuclear Information System (INIS)

    Lubenau, J. O.; Mould, R. F.

    2008-01-01

    The discovery of vanadium is described and the founding of the American Vanadium Company by Joseph Flannery (1867-1920) and its headquarters building in Pittsburgh in which was the stained glass window depicting the origin of the name Vanadium. Company orders for vanadium steel were obtained for the Panama canal and from Henry Ford. When his sister was diagnosed with cancer, Joseph Flannery withdrew from his vanadium interests and founded the Standard Chemical and Radium Chemical Companies which were the major suppliers of radium in the USA in the 1920s (before the Union Minicre du Haut Katanga commenced its commercial operations), processed from American mined carnotite in Colorado and Utah. Significant contributions to these enterprises involving vanadium and radium were also made by Joseph's elder brother, James Flannery (1848-1920). (author)

  18. PROGÊNIE EM MACHADO. ALGUMAS QUESTÕES EM MEMÓRIAS PÓSTUMAS DE BRÁS CUBAS E EM ESAÚ E JACÓ

    Directory of Open Access Journals (Sweden)

    ÉLIDE VALARINI OLIVER

    Full Text Available Resumo Este artigo busca tornar aparentes correntes subterrâneas que formam uma rede consistente de perspectivas teológicas, filosóficas e biológicas, que constantemente reaparecem nos romances e contos de Machado de Assis. Tal rede envolve temas persistentes tais como o da predestinação, o utilitarismo, o gnosticismo, a teoria da evolução e o assim chamado darwinismo social spenceriano. Tais temas estão tão intimamente ligados ao humanitismo que vale a pena perguntar se não seria a filosofia borbiana digna de um exame mais sério.

  19. Astronaut Joseph Kerwin takes blood sample from Astronaut Charles Conrad

    Science.gov (United States)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from Astronaut Charles Conrad Jr., Sylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series.

  20. Researcher Profile: An Interview with Joseph Goetz, Ph.D.

    Directory of Open Access Journals (Sweden)

    2010-10-01

    Full Text Available Dr. Joseph Goetz is an internationally known researcher working in academia to blend financial planning, financial counseling, and therapy approaches into tools and techniques that enhance the well-being of individuals and families. Dr. Goetz’s work in developing the ASPIRE clinic at the University of Georgia has helped place Georgia at the forefront of financial therapy research. In this interview readers of the Journal can learn more about the exciting work Dr. Goetz is doing to advance the Financial Therapy profession.

  1. Kepentingan Rusia Dalam Memberikan Suaka Politik Kepada Edward Joseph Snowden

    OpenAIRE

    ", Ibrahim; Iskandar, Irwan

    2017-01-01

    This research to explain interest of Russia with Snowden. Edward Joseph Snowden is a former Central Intelligence Agency (CIA) employee and a former contractor for National Security Agency (NSA) who leaked classified information to The Guardian and The Washington Post. Snowden who leaked classified information have Surveillance program doing by United State of America. The Surveillance Program is a cooperate between 9 big companies from United States, which: Yahoo!, Facebook, Google, Apple, Sk...

  2. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Science.gov (United States)

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  3. Psi Chi/APA Edwin B. Newman Graduate Research Award: Joseph H. Hammer

    Science.gov (United States)

    American Psychologist, 2009

    2009-01-01

    Joseph H. Hammer, recipient of the Psi Chi/APA Edwin B. Newman Graduate Research Award, is cited for an outstanding research paper whose findings provide important evidence regarding the promise of a male-sensitive approach to mental health marketing and empirically support the inclusion of theory-driven enhancements in group-targeted mental…

  4. The misadventures of a narrator and his servant: Machado de Assis and the characters of “A Semana”.

    Directory of Open Access Journals (Sweden)

    Ana Paula Cardozo de Souza

    2016-06-01

    Full Text Available Between 1892 and 1897 Machado de Assis published “A Semana”, his last and longest-running series of crônicas, in which it was possible to identify his opinions on the first years of the Brazilian Republic in between the lines. Commenting on the weekly events reported by the “Gazeta the Notícias” and other daily papers, the author criticized the ongoing attempts at hygienizing and modernizing Rio de Janeiro and the habits of its citizens. In his task, he created fictional characters to exemplify the contradictions inherent to the society and reflected in the press: the narrator and his servant, José Rodrigues. In this article, I analyze Rodrigues' appearances in “A Semana” and their possible significance in the context of a society undergoing profound changes while retaining some old customs.

  5. Astronaut Joseph Tanner is assisted into his EMU during training

    Science.gov (United States)

    1994-01-01

    Astronaut Joseph R. Tanner, STS-66 mission specialist, is assisted by Boeing suit expert Steve Voyles in donning the gloves for his extravehicular mobility unit (EMU) as he prepares to be submerged in a 25-feet deep pool at JSC's Weightless Environment Training Facility (WETF). Though no extravehicular activity (EVA) is planned for the mission, at least two astronauts are trained to perform tasks that would require a space walk in the event of failure of remote systems.

  6. De orgelmakers Joseph en Adam Binvignat : Maastrichtse orgelbouw in de nadagen van het Ancien Regime en in het begin van de moderne tijd

    NARCIS (Netherlands)

    Syrier, R.G.J.B.

    2014-01-01

    Joseph Binvignat was born in Attigny on 26 June 1755 and had been apprenticed to the Reims organ maker Louis Péronard. The first record of his presence in Maastricht is a document dated 7 September 1774, which mentions a tender submitted by Joseph Binvignat and Lambert Houtappel for repairs to the

  7. A discussion of stock market speculation by Pierre-Joseph Proudhon

    OpenAIRE

    Jean-Claude Juhel; Dominique Dufour

    2010-01-01

    International audience; The object of this contribution is to present the ideas behind the thinking of the French economist Pierre-Joseph Proudhon (1809-1865) in relation to the causes and effects of Stock market speculation. It is based upon the works of this author but particularly on his “Manuel du spéculateur à la Bourse” (Stock Market Speculator Manual) edited in 1857 in Paris. Compared to the markets of today, however, the stock market described by Proudhon appears embryonic. Neverthele...

  8. De Desdêmona a Capitu: Machado de Assis lê Shakespeare

    Directory of Open Access Journals (Sweden)

    Stélio Furlan

    2017-08-01

    Full Text Available Investigar a produção crítica machadiana, a partir da segunda metade do século XIX, como uma tentativa de definição teórica da crítica literária no Brasil é o que se pretende com este artigo. Trata-se de uma pesquisa sobre as condições de possibilidade da prática crítica, passando pela noção de valor (estratégia significante, pela questão do cânone e pelos processos de hibridação, modus operandi por excelência do discurso crítico machadiano. Nesse sentido, pretende-se refletir sobre a recepção do teatro shakespeariano nos ensaios críticos de Machado de Assis enquanto estratégia discursiva para a análise de O Primo Basílio, de Eça de Queirós (studium. E, como desdobramento lógico, cumpre discorrer sobre o trabalho da citação de Otelo, de Shakespeare, não só como “fonte” para o enredo de Dom Casmurro (1899, considerado “o mais subtil e genial romance de língua portuguesa” (LOURENÇO, 2015, p. 143, mas também para a gestação de Capitu, a personagem de ficção mais oblíqua e enigmática da textualidade machadiana (punctum.

  9. Reason, Science, Criticism. Joseph Agassi interviewed on his 90th birthday by Zuzana Parusniková

    Czech Academy of Sciences Publication Activity Database

    Parusniková, Zuzana; Agassi, J.

    2017-01-01

    Roč. 24, č. 4 (2017), s. 526-545 ISSN 1335-0668 Institutional support: RVO:67985955 Keywords : Joseph Agassi * interview Subject RIV: AA - Philosophy ; Religion http://klemens.sav.sk/fiusav/organon/?q=sk/reason- science -criticism

  10. Joseph de Maistre and Retributionist Theology

    Directory of Open Access Journals (Sweden)

    Gabriel Andrade

    2017-12-01

    Full Text Available Joseph de Maistre is usually portrayed as Edmund Burke’s French counterpart, as they both wrote important treatises against the French Revolution. Although Maistre did share many of Burke’s conservative political views, he was much more than a political thinker. He was above all a religious thinker who interpreted political events through the prism of a particular retributionist theology. According to this theology, God punishes evil deeds, not only in the afterlife, but also in this terrestrial life; and sometimes, he may even use human tyrants as instruments of his wrath. This interpretation especially evident in Maistre’s Considerations sur la France, an early work in his philosophical career. In that book, Maistre interprets the French Revolution as divine punishment, and in that regard, his views bear some similarities to the Deuteronomist historian in the Hebrew Bible, who interpreted the destruction of Jerusalem and the Babylonian Exile, as divine punishment in retribution of Israel’s sins.

  11. Johann Joseph on Geometrical-Optical Illusions: A Translation and Commentary.

    Science.gov (United States)

    Wade, Nicholas J; Todorović, Dejan; Phillips, David; Lingelbach, Bernd

    2017-01-01

    The term geometrical-optical illusions was coined by Johann Joseph Oppel (1815-1894) in 1855 in order to distinguish spatial distortions of size and orientation from the broader illusions of the senses. We present a translation of Oppel's article and a commentary on the material described in it. Oppel did much more than give a name to a class of visual spatial distortions. He examined a variety of figures and phenomena that were precursors of later, named illusions, and attempted to quantify and interpret them.

  12. Comparative Aesthetics of the Manly Face in the Parties of the Prophet Joseph and Zuleika from Safavid Era to the Contemporary Era

    Directory of Open Access Journals (Sweden)

    Maryam Shahbazi

    2017-02-01

    Full Text Available One of the noteworthy stories for the Iranian writers and painters is the story of Joseph and Zuleika. This story has elegantly been described many times in the poetry of Iranian famous poets and many painters have sought to illustrate this story. One of the themes of this story which has been considered in the present research is the party of Joseph and Zuleika in confronting with Egyptian women. Because the subject matter of this party has been Joseph’s beauty and it has been confirmed by a large number of people. Therefore, the painters have tried to picture the most beautiful human being by using all visual techniques. This research studies the aesthetics of the Joseph’s figure from Safavid School to the art of the contemporary era. With this assumption that in the Iranian painting, there has been a certain principle for painting the body and face of the most beautiful people; the present paper with the aim of finding the principles of men’s body and facial aesthetic has done the comparative study by concentration on the painting and designing of the body and face of Joseph in the figures. Some questions have been presented in this regard including whether it is possible to find an aesthetic approach common to all Iranian painting schools to show the most beautiful manly face and body? Whether exemplary beauty of Joseph is expressible by an indicator? What relation has the exemplary of Joseph had with the schools of Safavid art and the following schools? The method of this research is comparative and content analysis. The paper refers to the written and illustrated sources. The statistical society, including six ceremonies of painting and drawing, has been analyzed from Safavid school till the contemporary art; also, painter artists of this circle have been introduced. Matching the theoretical findings with the men’s most beautiful appearance manifested in the statue of majesty Joseph causes the acquisition of the embodied beauty

  13. Joseph Pulitzer II and Advertising Censorship, 1929-1939. Journalism Monographs Number Seventy-seven.

    Science.gov (United States)

    Pfaff, Daniel W.

    In an age of little or no consumer protection, the St. Louis "Post-Dispatch," under the guidance of Joseph Pulitzer II, was the first and most successful practitioner of self-imposed censorship of advertising, a practice that continues to this day. Beginning on May 1, 1929, the "Post-Dispatch" announced an aggressive program of…

  14. MRI of the spinocerebellar degeneration (multiple system atrophy, Holmes type, and Menzel-Joseph type)

    International Nuclear Information System (INIS)

    Mukai, Eiichiro; Makino, Naoki.

    1991-01-01

    We have analyzed MRI in 33 patients with several forms of spinocerebellar degeneration; 17 with multiple system atrophy, 10 with Holmes type, and 6 with Menzel-Joseph type. The MRIs were obtained using a 1.5-T GEMR System. Patients with multiple system atrophy demonstrated: atrophy of the brain stem, particularly basis pontis; decreased signal intensity of the white matter of pons; atrophy of the white matter of cerebellum; atrophy and decreased signal intensity of the putamen, particularly along their lateral and posterior portions; and atrophy of the cerebrum. Patients with Holmes type showed: atrophy of the cerebellum; atrophy of the vermis more than hemispheres; and nuclei of the cerebellum with no decreased intensity on T 2 -weighted sequences. Patients with Menzel-Joseph type demonstrated moderate atrophy of the brain stem and mild atrophy of the white matter of cerebellum. MRI is a useful diagnostic tool in the management of the spinocerebellar degeneration. (author)

  15. Skeptic Spirituality or the Accidental Buddhism of Machado de Assis's O Segredo do Bonzo

    Directory of Open Access Journals (Sweden)

    Dilip Loundo

    2014-09-01

    Full Text Available The objective of the present article is to support the idea that Machado de Assis’ work conforms well to what may be called a non-religious spirituality. For that, the article’s main focus is the analysis of the short story “O Segredo do Bonzo: Capítulo Inédito de Fernão Mendes Pinto”, published in 1882’s collection titled Papéis Avulsos, where the main principles of that spirituality, which is spread all over his work,  are given in a nutshell. In a first moment, we analise the intertextuality between Machado’s short story “O Segredo do Bonzo” and Portuguese Renaissance writer’s travelogue Peregrinação and the Machado’s nineteen century critique of the west’s main universalizing proposals: Christianity, scientificity and Enlightenment. In a second moment, we analise the philosophical implications of the primacy given to ‘opinion’ as an existential foundation and as a constitutive element of reality, in a context of close proximity with the soteriological traditions of ancient Greek skepticism, on the one hand, and Buddhism, on the other. A critic of religion, specially of Christian religion, Machado’s  ‘accidental’ association with Buddhism is symptomatic of a very peculiar form of non-religious spirituality.

  16. A luta entre impulso de vida e morte em "Viver!", de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Adilson dos Santos

    2016-01-01

    Full Text Available O conto “Viver!”, de Machado de Assis, ambientase no sonho de Ahasverus, o judeu condenado a vagar pelo mundo imortalmente por ter empurrado Jesus no seu percurso para a crucificação. Este aspecto onírico mostra-se revelador para a compreensão do protagonista, uma vez que, da leitura de seu sonho, o leitor consegue chegar às suas aspirações mais profundas. O conto o apresenta como sendo o último dos homens e, por esta razão, prestes a morrer, já que a pena imposta duraria até o findar da espécie humana. À primeira vista, tal condenação se caracterizaria como sendo por demais funesta. Nesse sentido, para ele, morrer seria um alívio. Todavia, até então, a morte estava excluída de seu horizonte. Não poderia perder a vida, visto que havia perdido a morte, o que demonstra que a pena imposta lhe foi igualmente conveniente, pois lhe garantiu a longevidade. A situação vivida em seu sonho vem justamente assinalar aquilo que o judeu mais anseia: viver. Palavras-Chave: Sonho; Vida; Morte.

  17. A LUTA ENTRE IMPULSO DE VIDA E MORTE EM "VIVER!", DE MACHADO DE ASSIS

    Directory of Open Access Journals (Sweden)

    Adilson dos Santos

    2016-01-01

    Full Text Available O conto “Viver!”, de Machado de Assis, ambientase no sonho de Ahasverus, o judeu condenado a vagar pelo mundo imortalmente por ter empurrado Jesus no seu percurso para a crucificação. Este aspecto onírico mostra-se revelador para a compreensão do protagonista, uma vez que, da leitura de seu sonho, o leitor consegue chegar às suas aspirações mais profundas. O conto o apresenta como sendo o último dos homens e, por esta razão, prestes a morrer, já que a pena imposta duraria até o findar da espécie humana. À primeira vista, tal condenação se caracterizaria como sendo por demais funesta. Nesse sentido, para ele, morrer seria um alívio. Todavia, até então, a morte estava excluída de seu horizonte. Não poderia perder a vida, visto que havia perdido a morte, o que demonstra que a pena imposta lhe foi igualmente conveniente, pois lhe garantiu a longevidade. A situação vivida em seu sonho vem justamente assinalar aquilo que o judeu mais anseia: viver. Palavras-Chave: Sonho; Vida; Morte.

  18. Response of the St. Joseph River to lake level changes during the last 12,000 years in the Lake Michigan basin

    Science.gov (United States)

    Kincare, K.A.

    2007-01-01

    The water level of the Lake Michigan basin is currently 177 m above sea level. Around 9,800 14C years B.P., the lake level in the Lake Michigan basin had dropped to its lowest level in prehistory, about 70 m above sea level. This low level (Lake Chippewa) had profound effects on the rivers flowing directly into the basin. Recent studies of the St. Joseph River indicate that the extreme low lake level rejuvenated the river, causing massive incision of up to 43 m in a valley no more than 1.6 km wide. The incision is seen 25 km upstream of the present shoreline. As lake level rose from the Chippewa low, the St. Joseph River lost competence and its estuary migrated back upstream. Floodplain and channel sediments partially refilled the recently excavated valley leaving a distinctly non-classical morphology of steep sides with a broad, flat bottom. The valley walls of the lower St. Joseph River are 12-18 m tall and borings reveal up to 30 m of infill sediment below the modern floodplain. About 3 ?? 108 m3 of sediment was removed from the St. Joseph River valley during the Chippewa phase lowstand, a massive volume, some of which likely resides in a lowstand delta approximately 30 km off-shore in Lake Michigan. The active floodplain below Niles, Michigan, is inset into an upper terrace and delta graded to the Calumet level (189 m) of Lake Chicago. In the lower portion of the terrace stratigraphy a 1.5-2.0 m thick section of clast-supported gravel marks the entry of the main St. Joseph River drainage above South Bend, Indiana, into the Lake Michigan basin. This gravel layer represents the consolidation of drainage that probably occurred during final melting out of ice-marginal kettle chains allowing stream piracy to proceed between Niles and South Bend. It is unlikely that the St. Joseph River is palimpsest upon a bedrock valley. The landform it cuts across is a glaciofluvial-deltaic feature rather than a classic unsorted moraine that would drape over pre-glacial topography

  19. From Chemical Analysis to Analyzing Chemical Education: An Interview with Joseph J. Lagowski

    Science.gov (United States)

    Cardellini, Liberato

    2010-01-01

    This interview provides glimpses of Joseph J. Lagowski and his life from the time he played with a Gilbert chemistry set, to his tenure at The University of Texas at Austin. His initial interest in chemistry was further nurtured and developed thanks to an excellent high school teacher. In the interview, Lagowski discusses his research in…

  20. Joseph McCabe: A Forgotten Early Populariser of Science and Defender of Evolution

    Science.gov (United States)

    Cooke, Bill

    2010-01-01

    Joseph McCabe (1867-1955) was one of the most prolific and gifted polymaths of the twentieth century. Long before such a thing was thought respectable, and almost a century before any university established a chair in the public understanding of science, McCabe made a living as a populariser of science and a critic of philosophical and religious…

  1. Joseph Roth, tradutor do Império perdido

    Directory of Open Access Journals (Sweden)

    Luis S. Krausz

    2015-06-01

    Full Text Available Este artigo discute um folhetim jornalístico do escritor austríaco Joseph Roth que trata de uma miniatura do Templo de Salomão, encontrada por ele num café da Hirtenstrasse berlinense, no coração do que foi, na década de 1920, o bairro habitado pelos judeus do Leste da Europa na capital alemã. A nostalgia, sob cujo signo foi criada tal miniatura, torna-se uma metáfora da nostalgia pelo império Austro-Húngaro, chave para a compreensão da obra romanesca deste escritor. Ao mesmo tempo, esta nostalgia rothiana é contextualizada no âmbito das crenças místicas e messiânicas do judaísmo tradicional.

  2. Arthur Conan Doyle, Joseph Bell, and Sherlock Holmes. A neurologic connection.

    Science.gov (United States)

    Westmoreland, B F; Key, J D

    1991-03-01

    Neurologists, like physicians in several other medical specialties, can lay claim to Sherlock Holmes as one of their own. This assertion is validated by the number of neurologic conditions, such as seizures, stroke, syncope, encephalopathies, and head trauma, that are mentioned in the stories and novels. In addition, the article reviews the powers of observation and the deductive approach utilized by Conan Doyle and Joseph Bell, the models for Sherlock Holmes, and how these skills can be applied to medical problems.

  3. Video Release: 47th Vice President of the United States Joseph R. Biden Jr. Speech at HUPO2017 Global Leadership Gala | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The Human Proteome Organization (HUPO) has released a video of the keynote speech given by the 47th Vice President of the United States of America Joseph R. Biden Jr. at the HUPO2017 Global Leadership Gala. Under the gala theme “International Cooperation in the Fight Against Cancer,” Biden recognized cancer as a collection of related diseases, the importance of data sharing and harmonization, and the need for collaboration across scientific disciplines as inflection points in cancer research.

  4. Joseph Davidovich Levit – the oretician and practitioner of national endocrinology (90th birthday anniversary

    Directory of Open Access Journals (Sweden)

    Shmuel Levit

    2016-12-01

    The main works of Dr. Joseph Levit, as well as his scientific biography may serve not only as a source of useful information, but also as an incentive for independent research for both the younger generation and the seasoned experts in various fields of medical science.

  5. 99mTc-DMSA Uptake in a Sister Mary Joseph's Nodule From Ovarian Cancer.

    Science.gov (United States)

    Naddaf, Sleiman; Azzumeea, Fahad; Fahad Alzayed, Mohammed

    2016-12-01

    A 50-year-old woman with ovarian cancer underwent Tc-DMSA scan to evaluate the functional status of the right hydronephrotic kidney. The images incidentally revealed a well-defined focus of mild radiotracer uptake at the midanterior abdominal wall, which correlated with a metastatic Sister Mary Joseph's nodule seen on CT performed a week earlier.

  6. Comments on the Poem “Architecture” by Joseph Brodsky

    Directory of Open Access Journals (Sweden)

    Konstantin Lidin

    2016-11-01

    Full Text Available The poem “Architecture” by Joseph Brodsky was commented on by Alexander Rappaport, Konstantin Lidin and Elena Bagina. The poem deserves to be studied at all architectural schools and to be learnt by heart by future architects; and the problems touched upon in this poem deserve to be thought about by architectural theorists. This poem is a quintessence of the contemporary theoretical thought about architecture. It raises such themes as time and memory, space, place and substance. It also speaks about ideal geometric shapes in architecture and dynamics of architectural forms. Architectural works are “a step beyond the drawing”, an unbreakable link of times. The domes of architectural masterpieces form a safety parachute of our civilization. Alexander Rappaport, Konstantin Lidin and Elena Bagina made a comment on each line of this short but remarkably concise, lofty and ironical work by Joseph Brodsky. These comments partially coincide and partially differ. You may either agree or argue with the authors’ opinion. But any meaningful talk about the place and the role of architecture and architectural profession in the present-day world is of importance. It is symptomatic that the modern architectural studies are focused on the history of architecture, being afraid (or unwilling due to a complex and controversial situation in today’s profession to deal with urgent and difficult problems. Wherever the architectural theory of the late 20th century looked for fertility drugs, be it in mathematics, semiotics, sociology, linguistics, it was in vain. In the early 21st century it came to the crossroads. It is no good to verify the death of architecture, because it would mean, according to Brodsky, the end of civilization. Let’s believe that architecture has its future and that it will remain “a thing of stone”, the strongest material on Earth.

  7. Joseph Rotblat: Moral Dilemmas and the Manhattan Project

    Science.gov (United States)

    Veys, Lucy

    2013-12-01

    John Fitzgerald Kennedy famously said, "One man can make a difference and every man should try."1 Joseph Rotblat (1908-2005) was the quintessence of Kennedy's conviction. He was the only scientist who left Los Alamos after it transpired that the atomic bomb being developed there was intended for use against adversaries other than Nazi Germany. I explore Rotblat's early research in Warsaw and Liverpool, which established his reputation as a highly capable experimental physicist, and which led him to join the Manhattan Project at Los Alamos in 1944. I examine his motivation for resigning from the project in 1945, and the unwillingness of his fellow scientists to follow suit, which draws attention to the continuing discourse on the responsibility of scientists for the consequences of their research.

  8. LEVANTAMENTO POPULACIONAL E ANÁLISE FAUNÍSTICA DE LEPIDOPTERA EM Eucalyptus spp. NO MUNICÍPIO DE PINHEIRO MACHADO, RS

    Directory of Open Access Journals (Sweden)

    Oderlei Bernardi

    2011-01-01

    Full Text Available The objective of this research was to collect, to study and to characterize the fauna of lepidopterous associated with Eucalyptus spp., plantation in the Municipality of Pinheiro Machado, in RS state. In the period of October 2005 to October 2007, every 15 days, collections of insects were accomplished with three light traps. After selection and transfixion procedures, the lepidopterous were identified based on entomological collections and specialized literature. Two thousand and twenty individuals belonging to 14 families, 106 genera and 220 species were collected. The families with the highest number of species collected were: Noctuidae (59, Geometridae (30, Arctiidae (28 and Saturniidae (14. According to the fauna classification the most species were considered not dominant, uncommon, rare and accidental. Among the species identified, there were some whose larvae are defoliators of the eucalypts: Oxydia agliata, (Geometridae, Sarsina violascens (Lymantriidae, Automeris illustris, Eacles imperialis magnifica and Lonomia obliqua (Saturniidae, which needs to have their populations monitored.

  9. A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Norie [Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556 (Japan); Department of Neurology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556 (Japan); Kamiguchi, Kenjiro; Nakanishi, Katsuya; Sokolovskya, Alice; Hirohashi, Yoshihiko; Tamura, Yasuaki; Murai, Aiko; Yamamoto, Eri; Kanaseki, Takayuki; Tsukahara, Tomohide; Kochin, Vitaly [Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556 (Japan); Chiba, Susumu [Department of Neurology, Clinical Brain Research Laboratory, Toyokura Memorial Hall, Sapporo Yamano-ue Hospital (Japan); Shimohama, Shun [Department of Neurology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556 (Japan); Sato, Noriyuki [Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556 (Japan); Torigoe, Toshihiko, E-mail: torigoe@sapmed.ac.jp [Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556 (Japan)

    2016-06-10

    Polyglutamine (polyQ) diseases comprise neurodegenerative disorders caused by expression of expanded polyQ-containing proteins. The cytotoxicity of the expanded polyQ-containing proteins is closely associated with aggregate formation. In this study, we report that a novel J-protein, DNAJ (HSP40) Homolog, Subfamily C, Member 8 (DNAJC8), suppresses the aggregation of polyQ-containing protein in a cellular model of spinocerebellar ataxia type 3 (SCA3), which is also known as Machado-Joseph disease. Overexpression of DNAJC8 in SH-SY5Y neuroblastoma cells significantly reduced the polyQ aggregation and apoptosis, and DNAJC8 was co-localized with the polyQ aggregation in the cell nucleus. Deletion mutants of DNAJC8 revealed that the C-terminal domain of DNAJC8 was essential for the suppression of polyQ aggregation, whereas the J-domain was dispensable. Furthermore, 22-mer oligopeptide derived from C-termilal domain could suppress the polyQ aggregation. These results indicate that DNAJC8 can suppress the polyQ aggregation via a distinct mechanism independent of HSP70-based chaperone machinery and have a unique protective role against the aggregation of expanded polyQ-containing proteins such as pathogenic ataxin-3 proteins.

  10. A Short Biography of Joseph Fourier and Historical Development of Fourier Series and Fourier Transforms

    Science.gov (United States)

    Debnath, Lokenath

    2012-01-01

    This article deals with a brief biographical sketch of Joseph Fourier, his first celebrated work on analytical theory of heat, his first great discovery of Fourier series and Fourier transforms. Included is a historical development of Fourier series and Fourier transforms with their properties, importance and applications. Special emphasis is made…

  11. Li-Fraumeni syndrome: Discovery and future challenges - Joseph Fraumeni Symposium

    Science.gov (United States)

    In May 2014, NCI’s Division of Cancer Epidemiology and Genetics (DCEG) hosted Cancer Epidemiology: From Pedigrees to Populations, a scientific symposium honoring 50 years of visionary leadership by Dr. Joseph F. Fraumeni, Jr., the founding Director of DCEG. In this video, Dr. Stephen Chanock of NCI provides opening remarks. Dr. David Schottenfeld of the University of Michigan moderates a session on the search for cancer susceptibility genes. Dr. Louise Strong of University of Texas MD Anderson Cancer Center speaks about the discovery and future challenges of Li-Fraumeni syndrome research. For more information on this symposium, visit http://dceg.cancer.gov/news-events/Fraumeni-symposium-speakers.

  12. O crepúsculo da ética imperial habsburga em Bruno Schulz e Joseph Roth The twilight of the Habsburg imperial ethics in Bruno Schulz and Joseph Roth

    Directory of Open Access Journals (Sweden)

    Luis S. Krausz

    2007-05-01

    Full Text Available Os escritores Bruno Schulz e Joseph Roth entraram para a história da literatura, respectivamente, como representantes da literatura polonesa e austríaca, como se pertencessem a mundos diversos. Entretanto ambos compartilharam de uma memória comum, que era a vida nas províncias orientais do Império Austro-Húngaro, nas cidades de Drohobycz e Brody, hoje pertencentes à Ucrânia. As obras de ficção de Schulz e de Roth fazem referência ao universo austro-húngaro e habsburgo, um reino milenar que via a si mesmo não simplesmente como uma realidade política, mas como um império que tinha como missão trazer a seus súditos uma forma de vida considerada superior do ponto de vista espiritual, ético e moral. A idéia do Sacro Império Romano Germânico, que se considerava portador de uma mensagem humana, subsistiu, até o século 20, no longo reinado do Kaiser Francisco José e neste sentido a 1ª Guerra Mundial significa não simplesmente o desmembramento político do Império Austro-Húngaro em seus diferentes componentes, mas também a falência de uma idéia de Estado que transcendia à esfera do meramente político para tornar-se um lar espiritual e cultural para seus súditos. O mundo que sobreveio à 1ª Guerra Mundial é marcado pelas tendências fáustico-titânicas de um individualismo materialista, que devota todas suas energias à produção e à acumulação de capital, e é sobre este novo mundo que Schulz e Roth olham em suas obras, sempre do ponto de vista de um universo anterior, marcado pela nostalgia de um exílio irreversível. Palavras-chave: Nostalgia. Exílio. Império Habsburgo. Joseph Roth. Bruno Schulz. Bruno Schulz and Joseph Roth figure in the history of literature as Representatives of Polish and Austrian literature, respectively, as if they were part of different worlds. However, both share a common memory: the life in the eastern provinces of the Austrian-Hungarian Empire, in the cities of Drohobycz

  13. ANTI-VISUAL EXPERIENCE AND ANTI-AESTHETIC PLEASURE IN LINGUISTIC CONCEPTUALISM: JOSEPH KOSUTH

    OpenAIRE

    Erhun Şengül

    2013-01-01

    1960s is a period that art was reshaped especially in Europe and in America and that is fed by its countercultural discourses. Duchamp’s conception of “art as idea” has pointed art’s anti-objective and idea dimension by coinciding with fields such as politics, philosophy, sociology and psychology. Conceptual artists such as Mel Bochner, Joseph Kosuth, Robert Barry, Lawrance Weiner, Terry Atkinson, played important role in foundation of the group “Art and Language” in England in 1968. As descr...

  14. Presenting Digital Archives with Historical GIS: Mapping Joseph Needham's Trips in WWII China

    Science.gov (United States)

    Wu, H.

    2017-12-01

    Since 2016, select groups of students (aged 14-17) from the Independent School Foundation Academy (ISF), Hong Kong, have been constructing a Historical GIS system for the Needham Research Institute (NRI), Cambridge, UK, during their annual summer school in Cambridge. Students read the diaries and reports of Joseph Needham, the Cambridge scientist who worked in China from 1943 to 1946 as the head of the Sino-British Science Cooperation Office, and mapped out both Needham's itineraries and the location of Chinese scientific institutions he visited. By taking part in this project, students learnt two sets of skills: the historian's skills of reading and analyzing primary sources, and the geographer's skills of creating datasets and maps with a GIS software. This project will be carried on in future years, to gradually include other trips Joseph Needham undertook in China in the second half of the 20th century, thus making an essential contribution to the digitalization and the diffusion of the NRI's archives. As a historical researcher in NRI and an educator, the presenter will offer some reflections on the benefit of historical GIS projects as a venue par excellence for research institutions and schools to join force, enhancing both academic research and teaching with an enlarged social impact.

  15. Ethnographic Research and Globalization: A Discussion of Joseph Tobin's Model of Video-Cued Multivocal Ethnography

    Science.gov (United States)

    Watras, Joseph

    2014-01-01

    Joseph Tobin made an impact on the field of comparative education in 2009 when he used a unique form of ethnography to illuminate the effects of world-wide forces, such as modernization, on schools in specific countries. Earlier, in 1989, he published "Preschool in Three Cultures" with co-authors David Wu and Dana Davidson. The…

  16. A giant urinary bladder stone in the mummy of Lebanese Maronite Patriarch Joseph Tyan (1760–1820) and its environmental and nutritional implications

    International Nuclear Information System (INIS)

    Capasso, L.; Licata, M.; Pinto, A.; Fernianos, F.; Azizi, T.; Manzoli, L.; Centrella, D.; D'anastasio, R.

    2017-01-01

    Introduction: Historical sources and anthropological investigations, with the indispensable support of radiology, bring to light pathological evidence of the past. Case presentation: The purpose of this article is to present the radiological investigation conducted on the mummy of the Maronite Joseph Tyan (1760–1820), a famous patriarch who guided the Lebanese Maronite community during a critical period of its history. The natural mummy of the Patriarch was temporarily removed from its burial site to certify the degree of preservation. Conventional radiography was necessary to determine the state of the internal organs and any physical abnormalities, and to clarify the degree of conservation of the mummy. Discussion: Radiological analysis uncovered an exceptional case of a large urinary bladder stone. This pathological evidence confirms historical documentary sources that in the last years of his life the Patriarch suffered from abdominal pain and urinary problems. We can suppose that the environment and diet of the Maronite community, limited by restricted agricultural resources, was the possible cause of the urinary bladder stone, as today the epidemiology of these diseases demonstrates links with mainly cereal diets in rural areas. - Highlights: • Paleoradiological analysis: a radiological approach to study mummies. • The anthropological and radiological analysis of the Mummy of Patriarch Joseph Tyan • Urinary bladder stone: radiological investigations. • Paleopathological literature of urinary bladder stone.

  17. Contra as invasões barbaras, a humanidade : a luta dos Arara (Karo) e dos Gavião (Ikoloehj) contra os projetos hidreletricos do Rio Machado, em Rondonia

    OpenAIRE

    Renata da Silva Nobrega

    2008-01-01

    Resumo: A dissertação trata da luta dos Arara (Karo) e dos Gavião (Ikólóéhj) contra os projetos hidrelétricos do Rio Machado, em Rondônia. Esta mobilização foi iniciada nos anos 80 contra o projeto da Usina Ji-Paraná, suspenso em 1993, e permanece até os dias atuais, com a retomada do projeto da Usina Tabajara. Frente às estratégias da ELETRONORTE para a viabilização destes projetos hidrelétricos, baseadas no mascaramento do seu potencial de destruição e no silenciamento da mobilização popula...

  18. Reflections on Preparing Educators to Evaluate the Efficacy of Educational Technology: An Interview with Joseph South

    Science.gov (United States)

    Bull, Glen; Spector, J. Michael; Persichitte, Kay; Meiers, Ellen

    2017-01-01

    Joseph South, an educational researcher, technology consultant, and former director of the U.S. Office of Educational Technology participated in a research initiative on Educational Technology Efficacy Research organized by the Jefferson Education Accelerator, Digital Promise, and the Curry School of Education at the University of Virginia. The…

  19. Euroopal jätkub väljakutseid ka peale laienemist / Joseph Daul ; interv. Kaja Sõrg

    Index Scriptorium Estoniae

    Daul, Joseph

    2008-01-01

    Euroopa Parlamendi Euroopa Rahvapartei ja Euroopa Demokraatide fraktsiooni esimees Joseph Daul vastab küsimustele, mis puudutavad fraktsiooni järgnevate aastate prioriteete, fraktsiooni peamisi saavutusi käesoleva koosseisu ajal, Euroopa ühise põllumajanduspoliitika tulevikku, fraktsioonikaaslase Tunne Kelami osalust fraktsiooni töös ning Euroopa Parlamendi ametliku asukoha võimalikku viimist Strasbourg'ist Brüsselisse

  20. The works of Joseph and Michael Haydn in Ondřej Horník's collection

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2017-01-01

    Roč. 9, 1-2 (2017), s. 14-23 ISSN 1803-7828 Institutional support: RVO:68378076 Keywords : music manuscripts * Joseph Haydn * Michael Haydn * Ondřej Horník's collection * church music Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Performing arts studies ( Music ology, Theater science, Dramaturgy) http://www.nm.cz/publikace/archiv.php?id=16

  1. A multi-method high-resolution geophysical survey in the Machado de Castro museum, central Portugal

    International Nuclear Information System (INIS)

    Grangeia, Carlos; Matias, Manuel; Hermozilha, Hélder; Figueiredo, Fernando; Carvalho, Pedro; Silva, Ricardo

    2011-01-01

    Restoration of historical buildings is a delicate operation as they are often built over more ancient and important structures. The Machado de Castro Museum, Coimbra, Central Portugal, has suffered several interventions in historical times and lies over the ancient Roman forum of Coimbra. This building went through a restoration project. These works were preceded by an extensive geophysical survey that aimed at investigating subsurface stratigraphy, including archeological remains, and the internal structure of the actual walls. Owing to the needs of the project, geophysical data interpretation required not only integration but also high resolution. The study consisted of data acquisition over perpendicular planes and different levels that required detailed survey planning and integration of data from different locations that complement images of the surveyed area. Therefore a multi-method, resistivity imaging and a 3D ground probing radar (GPR), high-resolution geophysical survey was done inside the museum. Herein, radargrams are compared with the revealed stratigraphy so that signatures are interpreted, characterized and assigned to archeological structures. Although resistivity and GPR have different resolution capabilities, their data are overlapped and compared, bearing in mind the specific characteristics of this survey. It was also possible to unravel the inner structure of the actual walls, to establish connections between walls, foundations and to find older remains with the combined use and spatial integration of the GPR and resistivity imaging data

  2. Tiede ja tutkijan sosiaalinen vastuu : Joseph Ben-Davidin, Roger Sperryn ja Knut Erik Tranøyn käsitykset tieteestä ja tutkijan sosiaalisesta vastuusta

    OpenAIRE

    Karppela, Lasse

    2006-01-01

    Science and the Scientist's Social Responsibility. Joseph Ben-David's, Roger Sperry's and Knut Erik Tranøy's Views of Science and the Scientist's Social Responsibility The aim of the study was to investigate, whether or not there is any connection between Jewish sociologist Joseph Ben-David's, American neuroscientist Roger Sperry's and Norwegian philosopher Knut Erik Tranøy's views of science and views of the scientist's social responsibility. The sources of information were their writin...

  3. Review: Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa (2013)

    OpenAIRE

    Reinhart Kößler; Arnold-Bergstraesser-Institut

    2015-01-01

    Review of the monograph:Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa, Potsdam: Potsdam University Press, 2013, ISBN 9783869562483, 300 pp. Besprechung der Monographie:Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa, Potsdam: Potsdam University Press...

  4. Joseph V. Denney, the Land-Grant Mission, and Rhetorical Education at Ohio State: An Institutional History

    Science.gov (United States)

    Mendenhall, Annie S.

    2011-01-01

    This essay provides an account of The Ohio State University's (OSU) rhetoric department during the tenure of Joseph Villiers Denney, arguing that he appropriated and repurposed national trends in education and rhetoric in ways that complicate the narrative of rhetoric and composition's decline in the late nineteenth century. In this essay, the…

  5. Johann Joseph Oppel (1855) on Geometrical–Optical Illusions: A Translation and Commentary

    Science.gov (United States)

    Todorović, Dejan; Phillips, David; Lingelbach, Bernd

    2017-01-01

    The term geometrical–optical illusions was coined by Johann Joseph Oppel (1815–1894) in 1855 in order to distinguish spatial distortions of size and orientation from the broader illusions of the senses. We present a translation of Oppel’s article and a commentary on the material described in it. Oppel did much more than give a name to a class of visual spatial distortions. He examined a variety of figures and phenomena that were precursors of later, named illusions, and attempted to quantify and interpret them. PMID:28694957

  6. Obituary: Richard Joseph Elston, 1960-2004

    Science.gov (United States)

    Jannuzi, Buell Tomasson; Bechtold, Jill

    2004-12-01

    Richard Joseph Elston, known for his development of innovative astronomical instrumentation, died on 26 January 2004 in Gainesville, Florida, after a four-year battle with Hodgkin's lymphoma. A professor of astronomy at the University of Florida, Richard had an unusually broad range of interests and skills, and a willingness to share his passion for astronomy with others, which made him a highly valued member of the astronomical community. Born 1 July 1960, in Albuquerque, New Mexico, Richard was the son of a geologist father and journalist mother. His childhood interest in astronomy and instrumentation matured as he majored in physics and astronomy at the University of New Mexico (BS, 1983) under the mentorship of Michael Zeilik. Richard pursued his PhD in astronomy at the University of Arizona and earned his degree in 1988. He pioneered the use of IR arrays for deep imaging surveys of the sky to study galaxy formation, and completed his thesis Search for Rapidly Forming Galaxies at High Redshift under the direction of George Rieke. Richard's graduate work included the first detection of galaxies at intermediate redshifts with evolved populations too red to have been identifiable from optical imaging surveys alone. In the Astrophysical Journal Letters in 1988, he, George Rieke, and Marcia Rieke reported the discovery of this new class of galaxies, now known as EROs (Extremely Red Objects), important as the possible progenitors of present day elliptical galaxies. Following post-doctoral positions at Kitt Peak National Observatory from 1988 to 1991 and at the Observatories of the Carnegie Institution of Washington from 1991 to 1992, Richard joined the scientific staff of Cerro Tololo Inter-American Observatory in Chile, part of the NSF's National Optical Astronomy Observatory. By 1994, he had become head of CTIO's IR instrumentation program and was leading the development of new instruments for the US astronomical community. In 1996, Richard married astronomer

  7. From Exile to Affirmation: The Poetry of Joseph Brodsky

    Directory of Open Access Journals (Sweden)

    David Patterson

    1993-06-01

    Full Text Available This article examines the relation between the exile of the poet from his homeland and the "exile of the word." The notion of the exile of the word pertains to the poet's problem of re-introducing meaning to the word—an excess of meaning that conveys more than the word can normally convey—through his poetry. Showing how the poet in exile becomes a poet of exile, the article examines what poetry has to do with a larger difficulty of exile and homelessness in human life. Brodsky's poetry, the article argues, addresses this very difficulty. The article concludes that the human capacity to dwell in the world is a capacity to instill the word with meaning, and that this is one important message to come to us through the poetry of Joseph Brodsky.

  8. Keeper of the nuclear conscience the life and work of Joseph Rotblat

    CERN Document Server

    Brown, Andrew

    2012-01-01

    Joseph Rotblat was the Jewish nuclear scientist whose disillusionment with nuclear weapons encouraged him to become one of the prime architects of the anti-nuclear movement, and resulted in his lifelong efforts to promote social responsibility in science. His founding of Pugwash and his humanitarian work ultimately led to his being awarded the Nobel Peace Prize. Rotblat's life, from his boyhood in Warsaw under siege and occupation in World War I to an active old age that brought honours and public recognition, is a compelling human story in itself. What gave it significance is the single-minde

  9. Joseph Rotblat: influences, scientific achievements and legacy

    Science.gov (United States)

    Underwood, Martin

    2008-11-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to science, and in particular to the medical applications of accelerators, radiation and radio-nuclides. In this article his early work and influences in Poland are described. He then joined James Chadwick at Liverpool University and began work on the cyclotron recently constructed there. Rotblat then, together with Chadwick, joined the Manhattan Project. This experience was to shape his life. He stayed at Los Alamos for less than a year before walking out. He was suspected of being a spy. Rotblat then became Professor of Physics at St Bartholomew's Medical College and pioneered the use of a 15 MeV linear accelerator in treatment and research. He made fundamental contributions to understanding the effects of the fallout from nuclear bomb tests. He also, together with Patricia Lindop, made important contributions to understanding the biological effects of radiation.

  10. Iterative CT reconstruction with small pixel size: distance-driven forward projector versus Joseph's

    Science.gov (United States)

    Hahn, K.; Rassner, U.; Davidson, H. C.; Schöndube, H.; Stierstorfer, K.; Hornegger, J.; Noo, F.

    2015-03-01

    Over the last few years, iterative reconstruction methods have become an important research topic in x-ray CT imaging. This effort is motivated by increasing evidence that such methods may enable significant savings in terms of dose imparted to the patient. Conceptually, iterative reconstruction methods involve two important ingredients: the statistical model, which includes the forward projector, and a priori information in the image domain, which is expressed using a regularizer. Most often, the image pixel size is chosen to be equal (or close) to the detector pixel size (at field-of-view center). However, there are applications for which a smaller pixel size is desired. In this investigation, we focus on reconstruction with a pixel size that is twice smaller than the detector pixel size. Using such a small pixel size implies a large increase in computational effort when using the distance-driven method for forward projection, which models the detector size. On the other hand, the more efficient method of Joseph will create imbalances in the reconstruction of each pixel, in the sense that there will be large differences in the way each projection contributes to the pixels. The purpose of this work is to evaluate the impact of these imbalances on image quality in comparison with utilization of the distance-driven method. The evaluation involves computational effort, bias and noise metrics, and LROC analysis using human observers. The results show that Joseph's method largely remains attractive.

  11. Magnetohydrodynamic boundary layer flow past a porous substrate with Beavers-Joseph boundary condition

    International Nuclear Information System (INIS)

    Jat, R.N.; Chaudhary, Santosh

    2009-01-01

    The flow of an electrically conducting fluid past a porous substrate attached to the flat plate with Beavers-Joseph boundary condition under the influence of a uniform transverse magnetic field has been studied. Taking suitable similar variables, the momentum equation is transformed to ordinary differential equation and solved by standard techniques. The energy equation is solved by considering two boundary layers, one in the porous substrate and the other above the porous substrate. The velocity and temperature distributions along with Nusselt number are discussed numerically and presented through graphs. (author)

  12. L’influence de l’eugénisme galtonien dans la pensée de Joseph Alois Schumpeter The Influence of Eugenics in Joseph Alois Schumpeter’s theory

    Directory of Open Access Journals (Sweden)

    Fabrice Dannequin

    2012-11-01

    Full Text Available Dans sa théorie du capitalisme, Joseph Alois Schumpeter mobilise l’eugénique, notamment les travaux de Francis Galton. Ce dernier a élaboré une vision hiérarchisée et héréditariste des hommes. Il l’a notamment appliquée à la question de la pauvreté en reprenant les données empiriques de Charles Booth. Schumpeter reprend ces éléments comme socle de l’explication de l’inégalité sociale et dans la construction de sa théorie de l’entrepreneuriat. Les entrepreneurs constituent une élite se démarquant de la masse, en engendrant l’évolution de la société du fait de leurs talents innés. Le capitalisme ne peut déboucher sur la disparition totale de la pauvreté. En effet, les individus biologiquement moins « dotés » sont condamnés à rester au bas de l’échelle sociale.In his theory about capitalism, Joseph Alois Schumpeter uses eugenics, and especially Francis Galton’s work. The former has conceived a hierarchized vision of society, and a hereditary vision of the transmission of talents. He notably applied it to the question of poverty by using Charles Booth’s empirical data. Schumpeter uses these elements both as an explanation of social inequality and as a basis of his theory of entrepreneurship. To him, the entrepreneurs are an elite standing out against the masses since they have the innate talents to generate evolution. Capitalism cannot totally eradicate poverty. Indeed, the least biologically gifted are bound to remain at the bottom of the social ladder.

  13. Correction to: Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event.

    Science.gov (United States)

    Berger, Joseph R; Malik, Vineeta; Lacey, Stuart; Brunetta, Paul; Lehane, Patricia B

    2018-04-10

    The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane 3 , was originally published electronically on the publisher's internet portal (currently SpringerLink).

  14. Análise dos casos de corrupção na Petrobras sob a ótica dos princípios regulatórios propostos por Joseph Stiglitz / Analysis of the cases of corruption in Petrobras from the point of view of the regulatory principles proposed by Joseph Stiglitz

    Directory of Open Access Journals (Sweden)

    Fernando Antônio da Silva Falcão

    2017-04-01

    Full Text Available Purpose – To find, in light of the principles of regulation proposed by Joseph Stiglitz, how government and market failures contributed to the occurrence of corruption cases in Petrobras. Methodology/approach/design – This article analyzes corruption scandals in Petrobras based on the information gathered in Operation Car Wash and, based on the principles of regulation established by Joseph Stiglitz, critically verifies how market and government failures contributed to the fraud, collusion and corruption in the state-owned enterprise. Findings – Market and government failures contributed decisively to the occurrence of corruption in the state-owned enterprise. Practical implications – The present study can help designing a regulatory framework that effectively discourages the practice of fraud, collusion and corruption in public bids.

  15. Follow-up Evaluation of Air Force Blood Donors Screening Positive for Chagas Disease

    Science.gov (United States)

    2017-08-27

    Blood Donors Screening Positive for Cbagas Disease presented at/published to Military Health System Research Symposium (Florida, 27-30 Aug 2017) in...disease upon blood donation at JBSA -Lackland 6. TITLE OF MATERIAL TO BE PUBLISHED OR PRESENTED: Follow-up evaluation of Air Force blood donors ...Designated Exempt Reviewer Follow-up evaluation of Air Force blood donors screening positive for Chagas disease Joseph Marcus1, Bryant Webber2, Leo Cropper2

  16. The art of Joseph Beuys and Vision Andreas Huyssen in Postmodernity A arte de Joseph Beuys e a visão de Andreas Huyssen na pós-modernidade

    Directory of Open Access Journals (Sweden)

    Lívia Garcez de Oliveira Padilha

    2012-04-01

    Full Text Available This article aims do present reflections on art in post-modernity, which encourages a reading of the ambivalence between the technique and aesthetics. We focus the environmentalist work of artist Joseph Beuys and the critical German essayist Andreas Huyssen and the paradoxical thinking of vanguard and mass culture. Is it possible to think like that in a dualist way? Or we can see a shift in sensitivity towards what touches us by affection? We believe, nevertheless, that exists a permanent state of artistic tension which stimulates a more relativistic than categorical culture in the XXI century.Este artigo tem como objetivo apresentar reflexões sobre a arte na pós-modernidade - que estimula uma leitura da ambivalência entre técnica e estética - por meio de duas obras “ambientalistas” do artista plástico Joseph Beuys e do olhar crítico, mas de cunho compreensivo, do ensaísta alemão Andreas Huyssen. O enfoque é o paradoxo entre a arte dita culta ou de vanguarda (? e a sua possível massificação (?. Estas duas expressões – vanguarda e massificação - ainda se sustentam na paisagem pós-moderna? Ou percebe-se um redirecionamento da sensibilidade em direção àquilo que nos toca pela afetividade? Consideramos, por meio da fenomenologia, que se enfrenta, em tempos pós-modernos, um permanente estado de tensionamento artístico, o que estimula uma visão mais relativista do que categórica da cultura no século XXI.

  17. Dimensões comunicacionais no conceito de escultura social de Joseph Beuys como possibilidade de tradução criativa.

    Directory of Open Access Journals (Sweden)

    Magda Salete Vicini

    Full Text Available O presente artigo é resultado de pesquisa de doutorado em Comunicação e Semiótica, realizada na PUC-SP, sobre o conceito de Escultura Social na obra de Joseph Beuys, com recorte em pesquisadores como Matthias Bunge e Caroline Tisdall, bem como a influência dos filósofos românticos Schiller, Goethe, Hegel e de Novalis na construção deste conceito na obra de Rudolf Steiner. O contexto da arte é abordado através de críticos de arte que analisam o trabalho artístico de Beuys, cujas características comunicacionais são apresentadas em relação a Humberto Maturana e Francisco Varella e à crítica da comunicação. Finalmente, o artigo aborda a possibilidade de tradução criativa (Walter Benjamin, Georg Steiner e Haroldo de Campos deste conceito de Joseph Beuys.

  18. Joseph Swan (1791-1874): pioneer of research on peripheral nerves.

    Science.gov (United States)

    Barton, N J; Smith, B D

    2008-06-01

    Joseph Swan was born in 1791 and appointed surgeon to Lincoln County Hospital in 1814. In addition to his clinical work, he carried out what were probably the first animal experiments on nerve injuries. These were mostly on rabbits, in which the sciatic nerves were partly or wholly divided, had a section excised, or were ligated. He found that regeneration could occur, even after neurectomy. He reported these results, together with his experience in human patients and the effects of neurectomy in a horse, in an essay of 1819, which won the Jacksonian Prize of the Royal College of Surgeons of England and is still preserved there. In 1827 he moved to London, where he devoted himself mainly to dissections of the nervous system and was active in the College. He retired to Filey in Yorkshire, where he died in 1874.

  19. Late quaternary stratigraphy and sedimentology of the inner part of southwest Joseph Bonaparte Gulf

    International Nuclear Information System (INIS)

    Clarke, J.D.A.

    2000-01-01

    Joseph Bonaparte Gulf is a large embayment on the northwestern continental margin of Australia. It is approximately 300 km east-west and 120 km north-south with a broad continental shelf to seaward. Maximum width from the southernmost shore of Joseph Bonaparte Gulf to the edge of the continental shelf is 560 km. Several large rivers enter the gulf along its shores. The climate is monsoonal. sub-humid, and cyclone-prone during the December-March wet season. A bedrock high (Sahul Rise) rims the shelf margin. The sediments within the gulf are carbonates to seaward, grading into clastics inshore. A seaward-thinning wedge of highstand muds dominates the sediments of the inner shelf of Joseph Bonaparte Gulf. Mud banks up to 15m thick have developed inshore. Coarse-grained sand ridges up to 15m high are found off the mouth of the Ord River. These overlie an Upper Pleistocene transgressive lag of mixed carbonate and gravelly siliciclastic sand. Four drowned strandlines are present on the inner shelf at depths of 20, 25, 28 and 30 m below datum. These are interpreted as having formed during stillstands in the Late Pleistocene transgression. Older strandlines at great depths are inferred as having formed during the fall in sea-level following the last highstand. For the most part the Upper Pleistocene-Holocene marine sediments overlie an erosion surface cut into older Pleistocene sediments. Incised valleys cut into this erosion surface are up to 5 km wide and have a relief of at least 20 m. The largest valley is that cut by the Ord River. Upper Pleistocene sediments deposited in the incised valleys include interpreted lowstand fluvial gravels, early transgressive channel sands and floodplain silts, and late transgressive estuarine sands and gravels. Spot samples were collected and subjected to 14 C dating, x-ray diffraction and palynological studies. Older Pleistocene sediments are inferred to have been deposited before and during the 120 ka highstand (isotope stage 5). They

  20. Colonel Joseph J. Reynolds and the Saint Patrick's Day Celebration on Powder River Battle of Powder River (Montana, 17 March 1876)

    National Research Council Canada - National Science Library

    Hedegaard, Michael

    2001-01-01

    The Battle of Powder River occurred on 17 March 1876 in southeastern Montana. Historians and researchers have consistently overlooked the importance of this battle on the outcome of the Great Sioux War of 1876. Colonel Joseph J...

  1. Acquisition of wood fuel at the Joseph C. McNeil Generating Station

    Energy Technology Data Exchange (ETDEWEB)

    Kropelin, W. [Burlington Electric Dept., VT (United States)

    1993-12-31

    The Joseph C. McNeil Generating Station is the world`s largest single boiler, municipally-owned, wood-fired electrical generating plant. The 50 megawatt McNeil Station is located in Burlington, Vermont and is owned by several Vermont public and private electric utilities. The operator and majority owner is the City of Burlington Electric Department (BED). Wood fuel procurement for the McNeil Station has been conducted in an environmentally sensitive way. Harvesting is carried out in conformance with a comprehensive wood chip harvesting policy and monitored by professional foresters. Unpredictable levels of Station operation require rigid adherence to a wood storage plan that minimizes the risk of over heating and spontaneous combustion of stockpiled fuel.

  2. Sympathetic science: Charles Darwin, Joseph Hooker, and the passions of Victorian naturalists.

    Science.gov (United States)

    Endersby, Jim

    2009-01-01

    This essay examines the complex tangle of emotional and scientific attachments that linked Darwin and botanist Joseph Dalton Hooker. Analyzing their roles as husbands, fathers, and novel readers demonstrates that possessing and expressing sympathy was as important for Victorian naturalists as it was for Victorian husbands. Sympathy was a scientific skill that Victorian naturalists regarded as necessary to fully understand the living world; although sympathy became increasingly gendered as feminine over the course of the century, its importance to male naturalists requires us to rethink the ways gender roles were negotiated in Victorian Britain. Botany was, for men like Darwin and Hooker, an acceptably masculine pursuit that nevertheless allowed--and even required--them to be sensitive and sympathetic.

  3. Baron von Zach's business relations with the Munich entrepreneur Joseph von Utzschneider (German Title: Geschäftsbeziehungen des Barons von Zach zu dem Münchner Unternehmer Joseph von Utzschneider)

    Science.gov (United States)

    Schneider, Ivo

    The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.

  4. Joseph Conrad's tormented Rescue (fantasy).

    Science.gov (United States)

    Freedman, William

    2014-02-01

    Joseph Conrad was a notoriously tormented writer for whom the creative act was often a punishment severe enough to drive him into paralyzing depressions that delayed the completion of his novels, sometimes for years. By far the most agonizing of these projects was The Rescue, a novel he began in 1898, abandoned a year later, tried unsuccessfully to continue several times over the next two decades, but was only able to resume in 1918 and to complete, after another tortured two-year struggle, in 1920. An explanation for this incapacity, that is powerfully suggested by the novel's evocative title and perhaps unintentionally ironic subtitle (A Romance of the Shallows) has not yet been explored. Using Freud's 1910 essay on the rescue fantasy, "Contributions to the Psychology of Love: A Special Type of Choice of Object Made by Men," and Emanuel Berman's instructive revision and expansion of the concept in his 2003 American Imago essay, "Ferenczi, Rescue, and Utopia," I argue that a substantial explanation for Conrad's tormented history with The Rescue is ascribable to its quite remarkably faithful treatment of a rescue fantasy with deep and disabling resonance for its author. More specifically, the difficulty was compounded by the novel's dramatization of the soul-crushing conflict between two such fantasies: one in the service of the masculine ideal of unflinching dedication to a heroic purpose, the other promising satisfaction to the equally potent demands of emotional and sexual desire. Features of Conrad's narrative fit so tightly and consistently with the theory as Freud (and Abraham) proposed and as Berman elaborated it that The Rescue offers itself as one of those rare and reinforcing instances wherein the literary text seems to validate the psychoanalytic theory at least as persuasively as the theory "understands" the text.

  5. Small-Molecule Antioxidant Proteome-Shields in Deinococcus Radiodurans

    Science.gov (United States)

    2010-09-01

    family of proteases [14] which appear to be activated by irradiation (Figure 4B). At least 10 complete open reading frames with considerable sequence...the experiments: MJD EKG VYM JGK RF DYL NBW GAV BSB RLL. Performed the experiments: MJD EKG VYM JGK RF DYL NBW GAV BSB RLL. Analyzed the data: MJD... EKG VYM JGK RF DYL NBW GAV BSB RLL. Wrote the paper: MJD RLL. References 1. Daly MJ, Gaidamakova EK, Matrosova VY, Vasilenko A, Zhai M, et al. (2007

  6. Territorial organization in Spain and in Colombia: “Report on Spain. Rethinking the State or destroying it”. Santiago Muñoz Machado

    Directory of Open Access Journals (Sweden)

    Catalina Ana Larach Del Castillo

    2013-12-01

    Full Text Available Two recently published books, one from Spain (Muñoz Machado, 2012 and the other from Colombia (Mendoza Martelo, 2013, evince concerns with respect to the territorial organization in both countries. What is the appeal of the territorial model? With common constitutional errors occurring in the territorial area, and a crisis in both function and coordination in various levels of the Government –as well as in the different regions and autonomous communities–, is legal reform preferable to constitutional change? These are some of the issues raised and evaluated in current debates. In the work in question, the main problems in Spain are analyzed and the author proposes ways of solving or diminishing these problems, such as a return to centralism, the partial conservation of autonomous communities, the replacement of the current model with a federal State, as well as the possibilities of self-determination and separatism. The proposed study will serve to revise certain aspects of Colombia’s territorial system, in order to determine whether or not reformation is necessary.

  7. Frequency and severity of rheumatic heart disease in the catchment area of Gauteng hospitals, 1993-1995

    NARCIS (Netherlands)

    Clur, Sally-Ann

    2006-01-01

    OBJECTIVE: Identification of frequency and severity of rheumatic fever/rheumatic heart disease (RF/RHD) in the catchment area of Gauteng hospitals. DESIGN: A retrospective descriptive analysis using hospital-based computer databases. SETTING: Helen Joseph, Chris Hani Baragwanath and Johannesburg

  8. Joseph Roth in den Niederlanden und Flandern: Vermittlung, Vernetzung und Orchestierung eines vielseitigen Autors im niederländischsprachigen Kontext 1924-1940

    NARCIS (Netherlands)

    Snick, E.S.

    2011-01-01

    This dissertation investigates the contemporary mediators and networks that played an important role in the canonization of Joseph Roth’s (original and translated) work in Flanders and the Netherlands. These mediators and networks made a substantial contributionto Roth’s intellectual and literary

  9. Joseph Priestley, oxygen, and the enlightenment.

    Science.gov (United States)

    West, John B

    2014-01-01

    Joseph Priestley (1733–1804) was the first person to report the discovery of oxygen and describe some of its extraordinary properties. As such he merits a special place in the history of respiratory physiology. In addition his descriptions in elegant 18th-century English were particularly arresting, and rereading them never fails to give a special pleasure. The gas was actually first prepared by Scheele (1742–1786) but his report was delayed. Lavoisier (1743–1794) repeated Priestley's initial experiment and went on to describe the true nature of oxygen that had eluded Priestley, who never abandoned the erroneous phlogiston theory. In addition to oxygen, Priestley isolated and characterized seven other gases. However, most of his writings were in theology because he was a conscientious clergyman all his life. Priestley was a product of the Enlightenment and argued that all beliefs should be able to stand the scientific scrutiny of experimental investigations. As a result his extreme liberal views were severely criticized by the established Church of England. In addition he was a supporter of both the French and American Revolutions. Ultimately his political and religious attitudes provoked a riot during which his home and his scientific equipment were destroyed. He therefore emigrated to America in 1794 where his friends included Thomas Jefferson and Benjamin Franklin. He settled in Northumberland, Pennsylvania although his scientific work never recovered from his forced departure. But the descriptions of his experiments with oxygen will always remain a high point in the history of respiratory physiology.

  10. Joseph Henry's Conception of Scientific Knowledge

    Science.gov (United States)

    Theerman, Paul

    1997-04-01

    Joseph Henry, America's premier physicist and physics teacher in the mid-nineteenth century, had decided views of scientific knowledge. These were expressed in two ways. First of all, scientific knowledge led to moral betterment. Thus the study of science was a morally good thing. This was not only because it led to the contemplation of God's creation, which was a standard reason justifying the study of science dating from the Scientific Revolution and even earlier. More importantly, the study of science itself was a moral discipline, imparting to scientists the habits and virtues of truthfulness, respect for others, care and diligence, and the discernment of meaningful patterns from experience. The moral ideals of science were expressed most strongly in Henry's upholding the international "Republic of Science"; conversely, cheapening science was a sign of moral failure. Second, for Henry and his generation, science provided a path to sure truth, separate from falsehood of both the politics and the quackery that characterized mid-century public life. Henry promoted this in his championing of the Smithsonian Institution a scientific establishment, against the ideas of others who wanted to make it a literary establishment or a training school for teachers. For Henry, the Smithsonian's scientific reputation would be established by relying on careful peer review in its publications, and supporting established scientists to write authoritative popular works. The purpose of both these activities was to raise the profile of science in the United States and further establish science and the scientific method as a guide to public life.

  11. Pierre-Joseph Proudhon, Du principe de l’art et de sa destination sociale, 1865

    OpenAIRE

    2017-01-01

    Introduction par Anne-Marie Bouchard Amalgamant le devenir historique des classes sociales (aristocratie et bourgeoisie) et le devenir social des formes de l’art (art pour l’art et art social), Pierre-Joseph Proudhon (1809-1865) propose dans Du principe de l’art et de sa destination socialeune lecture très personnelle de l’histoire de l’art des Égyptiens à Courbet, de laquelle il prétend extraire « la théorie la plus complète de l’art ». 1. Gustave Courbet, Les Casseurs de pierres, 1849 Œuvr...

  12. Joseph Jastrow, the psychology of deception, and the racial economy of observation.

    Science.gov (United States)

    Pettit, Michael

    2007-01-01

    This article reconstructs the recurring themes in the career of Joseph Jastrow, both inside and outside the laboratory. His psychology of deception provides the bridge between his experimental and popular pursuits. Furthermore, Jastrow's career illustrates the complex ways in which scientific psychology and pragmatist philosophy operated within the constraints of a moral economy deeply marked by notions of "race." Psychological investigations of deception were grafted onto two of the human sciences' leading tools: the evolutionary narrative and the statistical analysis of populations. Such associations abetted the racialization of the acts of deceiving and being deceived. These connections also were used to craft moral lessons about how individuals ought to behave in relationship to the aggregate population and natural selection's endowment.

  13. Joseph Henry’s role in the discovery of electromagnetic induction

    International Nuclear Information System (INIS)

    Smith, Glenn S

    2017-01-01

    The discovery of electromagnetic induction in the early part of the 19th century is one of the greatest scientific achievements of all time, and it has had tremendous technological consequences. The credit for this discovery rightfully goes to the great English experimental physicist Michael Faraday. However, the American physicist Joseph Henry made some observations comparable to Faraday’s at nearly the same time, and for that reason, Faraday and Henry are often considered to be co-discoverers of some aspects of electromagnetic induction. We examine Henry’s early research on electromagnetism, starting from his efforts to improve the electromagnet, which led directly to his investigations of induction. We describe his earliest experiments on both mutual and self-induction, and pay particular attention to the relationship of Henry’s research to that of Faraday. The approach is one in which the experiments are described and then analysed using modern theory and terminology. (paper)

  14. The fantastic in Thomas Mann's Der Tod in Venedig and Joseph und seine Brüder

    OpenAIRE

    Nolan, Tom

    2011-01-01

    The thesis includes an introductory survey of recent relevant secondary literature and a coda dealing with the fantastic as a manifestation of Schiller’s ‘Spieltrieb’. Its main body, however, is comprised of three substantial chapters prosecuting two interlinked arguments: (1) that Der Tod in Venedig and Joseph und seine Brüder are fantastic narratives and (2) that the fantastic in these narratives works hand in glove with Mann’s philosophical concerns. In order to demonstrate that the fir...

  15. Defining American Heroes: Analyzing the Metamorphosis of the War Hero in Twentieth Century War Films Using Joseph Campbell's, "Hero's Journey."

    Science.gov (United States)

    Frith, Luci A.

    In "The Hero's Journey" Joseph Campbell identifies the patterns that inform the myths of the "hero" throughout recorded history. By using Campbell's template, this paper examines how the American war hero is portrayed and has been portrayed in film. The paper states that Americans not only define their war heroes in films but…

  16. Percepciones de la comunidad del barrio Machado del Municipio de Copacabana - Valle de Aburrá (Antioquia) con relación a la explotación minera y su afectación al recurso hídrico en el marco del desarrollo sostenible.

    OpenAIRE

    Mejía Vélez, Mónica Patricia

    2015-01-01

    Tesis de grado (Maestría en Desarrollo Sostenible y Medio Ambiente). Universidad de Manizales. Facultad de Ciencias Contables Económicas y Administrativas, 2015 Esta investigación se orientó a conocer las percepciones de los habitantes de la comunidad del barrio Machado del Municipio de Copacabana - Valle de Aburrá (Antioquia), frente a las actividades de explotación minera a cielo abierto y su afectación al recurso hídrico, las cuales se desarrollan cercanas al sector mencionado, por...

  17. Joseph McCabe: A Forgotten Early Populariser of Science and Defender of Evolution

    Science.gov (United States)

    Cooke, Bill

    2010-05-01

    Joseph McCabe (1867-1955) was one of the most prolific and gifted polymaths of the twentieth century. Long before such a thing was thought respectable, and almost a century before any university established a chair in the public understanding of science, McCabe made a living as a populariser of science and a critic of philosophical and religious obscurantism. Through the first half of the twentieth century he wrote countless cheap and widely distributed books and pamphlets for those whose thirst for knowledge exceeded the money or time they could devote to such pursuits. This article will detail, and give some assessment of, McCabe’s career as a populariser of science and expositor of evolutionary theory and its philosophical, religious and cultural ramifications.

  18. Moths on the Flatbed Scanner: The Art of Joseph Scheer

    Directory of Open Access Journals (Sweden)

    Stephen L. Buchmann

    2011-12-01

    Full Text Available During the past decade a few artists and even fewer entomologists discovered flatbed scanning technology, using extreme resolution graphical arts scanners for acquiring high magnification digital images of plants, animals and inanimate objects. They are not just for trip receipts anymore. The special attributes of certain scanners, to image thick objects is discussed along with the technical features of the scanners including magnification, color depth and shadow detail. The work of pioneering scanner artist, Joseph Scheer from New York’s Alfred University is highlighted. Representative flatbed-scanned images of moths are illustrated along with techniques to produce them. Collecting and preparing moths, and other objects, for scanning are described. Highlights of the Fulbright sabbatical year of professor Scheer in Arizona and Sonora, Mexico are presented, along with comments on moths in science, folklore, art and pop culture. The use of flatbed scanners is offered as a relatively new method for visualizing small objects while acquiring large files for creating archival inkjet prints for display and sale.

  19. Electrical Enlightenment: Joseph Priestley's Historical and Experimental Studies of Electricity

    Science.gov (United States)

    Boantza, Victor

    Joseph Priestley (1733-1804) was one of the most controversial public figures of the eighteenth century. A true Enlightenment polymath, he wrote more than two hundred books, pamphlets, sermons, and essays on subjects ranging from science to politics and from metaphysics to theology. He was a religious dissenter, political radical, vocal supporter of the French Revolution, and lifelong defender of the losing side in the Chemical Revolution. Priestley is best known for having ``discovered'' oxygen in the 1770s and for his lasting contributions to pneumatic chemistry. Yet his first scientific fascination, while teaching at Warrington Academy, was electricity--one of the greatest scientific fads of the Enlightenment. Priestley's work on electricity, both historical and experimental, culminated in his History and Present State of Electricity (1767), which became a standard textbook on the subject for nearly a century, and went through numerous editions and translations. Situating Priestley's electrical investigations against the background of eighteenth-century ideals of scientific theory and practice, especially concerning physics, experimental philosophy, and natural history, illuminates the relations between science, society, and epistemology in the Enlightenment.

  20. Joseph Rotblat a man of conscience in the nuclear age

    CERN Document Server

    Underwood, Martin

    2009-01-01

    Professor Sir Joseph Rotblat was a distinguished scientist who made a significant contribution to nuclear physics, worked on the development of the atomic bomb (he was the only person to leave the Manhattan Project), and was suspected of being a Soviet spy. After Hiroshima and Nagasaki he became a peace campaigner and dedicated himself to the medical uses of nuclear physics and radiation.He took up the post of Professor of Physics (as applied to medicine) at St. Bartholomew's Medical College and made major contributions to this field, becoming one of the world's leading researchers into the biological effects of radiation. … His life from the early 1950s until his death in August 2005 was devoted to the abolition of nuclear weapons and the promotion of world peace. His work ranked with that of Albert Einstein and Bertrand Russell. He helped found The Pugwash Conferences on Science and World Affairs, and together with Pugwash he was awarded the Nobel Peace Prize in 1995. Rotblat promoted dialogue between Sov...

  1. Atrazine Concentrations in Stream Water and Streambed Sediment Pore Water in the St. Joseph and Galien River Basins, Michigan and Indiana, May 2001 - September 2003

    National Research Council Canada - National Science Library

    Duris, Joseph W; Reeves, Howard W; Kiesler, James L

    2004-01-01

    The U.S. Geological Survey (USGS) sampled multiple stream sites across the St. Joseph and Galien River Basins to detect and quantify the herbicide atrazine using a field enzyme-linked immunosorbent assay (ELISA) triazine test...

  2. [Dr. Joseph Chazanowicz (1844-1919) and the National Library in Jerusalem].

    Science.gov (United States)

    Ohry, Avi

    2014-01-01

    Dr. Joseph Chazanowicz (1844-1919), was a Russian physician, and founder of the Jewish National Library in JerusaLem. After completing his studies at the Jewish school and at the gymnasium of Grodno, Chazanowicz went to Königsberg, Germany to study medicine and finished his studies in 1872. Returning to Russia, he began to practice at Byelostok's Jewish hospital. Chazanowicz founded the Hovevei Ziyyon ["Lovers of Zion"] society and also the Linat Ha-Zedek ("Hospice for the Poor")--caring for the poor. In 1890 he visited Palestine and conceived the idea of founding a library in Jerusalem, together with the B'nai B'rith organization. In 1896 he sent his large collection of books, amounting to nearly 10,000 volumes, to Jerusalem as the beginning of the Abarbanel library. The enlargement of this library and the collection of funds to erect a special building for it became the life-work of Chazanowicz.

  3. The Chief Joseph Hatchery Program 2013 Annual Report

    Science.gov (United States)

    Baldwin, Casey; Pearl, Andrea; Laramie, Matthew; Rohrback, John; Phillips, Pat; Wolf, Keith

    2016-01-01

    The Chief Joseph Hatchery is the fourth hatchery obligated under the Grand Coulee Dam/Dry Falls project, originating in the 1940s. Leavenworth, Entiat, and Winthrop National Fish Hatcheries were built and operated as mitigation for salmon blockage at Grand Coulee Dam, but the fourth hatchery was not built, and the obligation was nearly forgotten. After the Colville Tribes successfully collaborated with the United States to resurrect the project, planning of the hatchery began in 2001 and construction was completed in 2013. The monitoring program began in 2012 and adult Chinook Salmon were brought on station for the first time in June 2013. BPA is the primary funding source for CJH, and the Mid-Columbia PUDs (Douglas, Grant and Chelan County) have entered into cost-share agreements with the tribes and BPA in order to meet some of their mitigation obligations. The CJH production level was set at 60% in 2013 in order to train staff and test hatchery facility systems during the first year of operation. Leavenworth National Fish Hatchery (LNFH) provided 422 Spring Chinook broodstock in June, 2013; representing the official beginning of CJH operations. In July and August the CCT used a purse seine vessel to collect 814 summer/fall Chinook as broodstock that were a continuation and expansion of the previous Similkameen Pond program. In-hatchery survival for most life stages exceeded survival targets and, as of April 2014, the program was on track to exceed the 60% production target for its start-up year. The CJH monitoring project collected field data to determine Chinook population status, trend, and hatchery effectiveness centered on five major activities; 1) rotary screw traps (juvenile outmigration, natural-origin smolt PIT tagging) 2) beach seine (naturalorigin smolt PIT tagging) 3) lower Okanogan adult fish pilot weir (adult escapement, proportion of hatchery-origin spawners [pHOS], broodstock) 4) spawning ground surveys (redd and carcass surveys)(viable salmonid

  4. Movement disorders in hereditary ataxias.

    Science.gov (United States)

    Garcia Ruiz, Pedro J; Mayo, David; Hernandez, Jaime; Cantarero, Susana; Ayuso, Carmen

    2002-10-15

    Movement disorders are well known features of some dominant hereditary ataxias (HA), specially SCA3/Machado-Joseph disease and dentatorubropallidolusyan atrophy. However, little is known about the existence and classification of movement disorders in other dominant and recessive ataxias. We prospectively studied the presence of movement disorders in patients referred for HA over the last 3 years. Only those patients with a confirmed family history of ataxia were included. We studied 84 cases of HA, including 46 cases of recessive and 38 cases of dominant HA. Thirty out of 46 cases of recessive HA could be classified as: Friedreich ataxia (FA), 29 cases; vitamin E deficiency, 1 case. Twenty-three out of 38 cases of dominant HA could be classified as: SCA 2, 4 cases; SCA 3, 8 cases; SCA 6, 4 cases; SCA 7, 6 cases and SCA 8, 1 case. We observed movement disorders in 20/38 (52%) patients with dominant HA and 25/46 (54%) cases with recessive HA, including 16 patients (16/29) with FA. In general, postural tremor was the most frequent observed movement disorder (27 cases), followed by dystonia (22 cases). Five patients had akinetic rigid syndrome, and in 13 cases, several movement disorders coexisted. Movement disorders are frequent findings in HA, not only in dominant HA but also in recessive HA. Copyright 2002 Elsevier Science B.V.

  5. Imaginário religioso: o simbolismo do herói à luz de Joseph Campbell e Carl Gustav Jung. 2011.

    Directory of Open Access Journals (Sweden)

    Solange Missagia Matos

    2013-03-01

    Full Text Available DISSERTAÇÃO DE MESTRADOMATTOS, Solange Missagia. Imaginário religioso: o simbolismo do herói à luz de Joseph Campbell e Carl Gustav Jung. 2011. 115 folhas. Dissertação (Mestrado – Pontifícia Universidade Católica de Minas Gerais, Programa de Pós-graduação em Ciências da Religião, Belo Horizonte.

  6. “When Joseph awoke, he did as the angel of the Lord had commanded him” (Mt 1 : 24. Discreet, Effective Service

    Directory of Open Access Journals (Sweden)

    Tomasz Maria Dąbek

    2013-03-01

    Full Text Available Saint Joseph was a righteous man. He respected the Law of Israel. The decision to divorce Mary after she was found with child was not an easy one, although he knew he was not the child’s father. Instructed by the angel of the Lord, he took her to his home, gave a name to her child as his legal guardian (Mt 1 : 18–25, took care of his wife and her child, organised their trip to Egypt (Mt 2 : 13–15, then their return to Palestine and life in Nazareth (Mt 2 : 19–23; cf. Lk 2 : 39–52. His active obedience to God is the fulfilment of all the things Saint James will later describe as faith shown by the works of the faithful (Jas 2 : 14–17. 20–26. Joseph is put among those who bear witness to the faith of the Old Testament. The Gospels give no account of his exact words, although he fulfilled everything that he had been commanded. Saint Joseph can be a patron of everyone who tries to fulfil God’s will in a discreet and effective manner, with perseverance produced by faith (cf. Jas 1 : 3f.. With his works and life he shows how to bridle your tongue (cf. Jas 1 : 26f.; 3 : 1–13 and take care of the ones that need it the most (cf. Jas 1 : 27; 3 : 13, discreetly fulfilling your duties.

  7. Relationship between overnight energy expenditure and BMR measured in a room-sized calorimeter.

    Science.gov (United States)

    Seale, J L; Conway, J M

    1999-02-01

    The purpose of this study was to determine if overnight energy expenditure, the lowest energy expenditure sustained for 60 min during the night, measured and predicted basal metabolic rate are equivalent. Overnight energy expenditure (ON-EE), the lowest energy expenditure sustained for 60 min during sleep (LS-EE) and basal metabolic rate (BMR) were measured two to seven times in a room-sized indirect calorimeter in 69 adult subjects. Subjects' gender, age, weight and height were also used to predict BMR (FAO/WHO/UNU, 1985) (BMR-WHO). Beltsville Human Nutrition Research Center, Beltsville, MD, USA. The results from calorimetry measurements (mean +/- s.d.) included: ON-EE (6.87 +/- 0.99 MJ/d), LS-EE (6.18 +/- 0.94 MJ/d) and BMR (6.87 +/- 0.99 MJ/d). Predicted BMR mean was: BMR-WHO, 6.95 +/- 1.03. The mean within-subject difference for the calorimetry measurements were: ON-EE, 0.21 MJ/d; LS-EE, 0.16 MJ/d; and BMR, 0.34 MJ/d. Results indicate there was no significant difference between ON-EE, BMR and BMR-WHO. LS-EE was significantly lower (P BMR and BMR-WHO. These results indicate that while metabolic rate drops significantly below BMR during sleep, overnight metabolic rate and BMR are equivalent.

  8. A delicate balance global perspectives on innovation and tradition in the history of mathematics a festschrift in honor of Joseph W. Dauben

    CERN Document Server

    Horng, Wann-Sheng

    2015-01-01

    Joseph W. Dauben, a leading authority on the history of mathematics in Europe, China, and North America, has played a pivotal role in promoting international scholarship over the last forty years. This Festschrift volume, showcasing recent historical research by leading experts on three continents, offers a global perspective on important themes in this field.

  9. "Four Ways of Writing the City" : St. Petersburg-Leningrad as a Metaphor in the Poetry of Joseph Brodsky

    OpenAIRE

    Könönen, Maija

    2003-01-01

    The present study discusses the theme of St. Petersburg-Leningrad in Joseph Brodsky's verse works. The chosen approach to the evolving im-age of the city in Brodsky's poetry is through four metaphors: St. Petersburg as "the common place" of the Petersburg Text, St. Petersburg as "Paradise and/or Hell", St. Petersburg as "a Utopian City" and St. Petersburg as "a Void". This examination of the city-image focusses on the aspects of space and time as basic categories underlying the poet's po...

  10. Review: Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa (2013)

    OpenAIRE

    Reinhart Kößler

    2015-01-01

    Review of the monograph:Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa, Potsdam: Potsdam University Press, 2013, ISBN 9783869562483, 300 pp.

  11. 33 CFR 334.670 - Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west of...

  12. Being a Stranger and the Strangeness of Being: Joseph Conrad's "The Secret Sharer" as an Allegory of Being in Education

    Science.gov (United States)

    Schwieler, Elias

    2013-01-01

    Joseph Conrad's "The Secret Sharer" has often been associated with what can be called initiation stories. However, in this article I argue that Conrad's text is more than that. It can, I suggest, be read as an allegory of the inaccessibility to reveal the essence of being in command, being in education, and also the…

  13. Recepción histórica de la música eclesiástica de Joseph Haydn en los archivos musicales catedralicios de la Comunidad Valenciana

    Directory of Open Access Journals (Sweden)

    Aparisi Aparisi, José

    2008-12-01

    Full Text Available As far as I know, no research has been done so far on the reception of Joseph Haydn’s music, particularly that concerning the liturgical repertoire, in Latin, in the main centres of production of church music in the Valencian Community. The first source with music by Haydn, dated in Valencia in 1789, when the musician’s composing activity was at its best —the organ part of the “Grosse Orgelsolomesse” (“Great Organ Solo Mass”—, appears in Valencia only three years after he composed Die sieben letzten Worte unseres Erlösers am Kreuze (“The Seven Last Words of our Saviour on the Cross” commissioned to Haydn by the Hermandad of the Santa Cueva in Cadiz. On the other hand, the number of compositions wrongly attributed to Joseph Haydn is, in all probability, much higher when it comes to church music than any other genre, which offers a wide and interesting fi eld to study.

    Hasta donde conozco, no se ha realizado hasta la fecha un estudio sobre la recepción de la música, particularmente en lo referido al repertorio litúrgico —en latín— de Joseph Haydn, en los principales centros de producción musical eclesiástica de la Comunidad Valenciana. La primera fuente con música de Haydn datada en Valencia, en 1789, en plena actividad compositiva del músico de Rohrau —la parte para el órgano de la “Grosse Orgelsolomesse” (“Gran Misa para solo de órgano”—, aparece en Valencia sólo tres años después de la composición de Die sieben letzten Worte unseres Erlösers am Kreuze (“Las Siete últimas Palabras de Nuestro Salvador en la Cruz”, fruto del encargo que hiciera la Hermandad de la Santa Cueva de Cádiz al compositor. Por lo demás, el número de atribuciones de composiciones, equivocadamente adjudicadas a Joseph Haydn es, seguramente en el campo de la música de iglesia, mucho mayor que en otros géneros, lo que ofrece un amplio e interesante campo sobre el cual poder

  14. Determination of the spatial movement of the temporomandibular joints (tmj joint heads in patients with muscle and joint dysfunction according to computed tomography (ct

    Directory of Open Access Journals (Sweden)

    Аркадий Максимович Боян

    2015-11-01

    heads relative to articular tubercle (at p≤0,005 were detected in all patients with MJD. After treatment and removal of the symptoms of disease the parameters of mandibular heads in socket approached to the normal ones (at p≤0,005. The use of CT for spatial determination of mandibular joint heads can be considered as an additional objective method of diagnostics for successful treatment of patients with TMJ MJD

  15. Review: Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa (2013

    Directory of Open Access Journals (Sweden)

    Reinhart Kößler

    2015-01-01

    Full Text Available Review of the monograph:Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa, Potsdam: Potsdam University Press, 2013, ISBN 9783869562483, 300 pp.

  16. Joseph Clover and the cobra: a tale of snake envenomation and attempted resuscitation with bellows in London, 1852.

    Science.gov (United States)

    Ball, C

    2010-07-01

    The Industrial Revolution saw the creation of many new jobs, but probably none more curious than that of zookeeper. The London Zoological Gardens, established for members in 1828, was opened to the general public in 1847. In 1852 the "Head Keeper in the Serpent Room", Edward Horatio Girling, spent a night farewelling a friend departing for Australia. He arrived at work in an inebriated state and was bitten on the face by a cobra that he was handling in a less than sensible manner. He was taken by cab to University College Hospital where he was resuscitated by a number of doctors, including Joseph Clover then the resident medical officer to the hospital and later to become the leading anaesthetist in London. Clover recorded this event in his diary along with the resuscitation method used. The patient eventually died but his treatment created a flurry of correspondence in the medical and lay press. Interestingly, the attempted resuscitation was with bellows, which had been abandoned by the Royal Humane Society twenty years earlier Clover records other cases of resuscitation with bellows at University College Hospital during his time as a resident medical officer there (1848 to 1853). There is a casebook belonging to Joseph Clover in the Geoffrey Kaye Museum, in Melbourne. This story is one of the many interesting stories uncovered during a study of this book and Clover's other personal papers.

  17. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2000 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Lockwood, Jr., Neil [Kalispel Tribe of Indians, Usk, WA (United States); McLellan, Jason G [Washington Department of Fish and Wildlife, Spokane, WA (United States); Crossley, Brian [Spokane Tribe of Indians, Department of Natural Resources, Wellpinit, WA (United States); O' Connor, Dick

    2001-01-01

    The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, commonly known as the Joint Stock Assessment Project (JSAP) is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (blocked area). The three-phase approach of this project will enhance the fisheries resources of the blocked area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information housed in a central location will allow managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP (NWPPC program measure 10.8B.26) is designed and guided jointly by fisheries managers in the blocked area and the Columbia Basin blocked area management plan (1998). The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of blocked area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the blocked area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. The use of common collection and analytical tools is essential to the process of streamlining joint management decisions. In 1999 and 2000 the project

  18. Conformance to Regulatory Guide 1.97, Joseph M. Farley Nuclear Plant, Unit Nos. 1 and 2 (Docket No. 50-348 and 50-364)

    International Nuclear Information System (INIS)

    Stoffel, J.W.

    1985-05-01

    This EG and G Idaho, Inc., report reviews the submittals for Regulatory Guide 1.97 for Unit Nos. 1 and 2 of the Joseph M. Farley Nuclear Plant and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified

  19. Narrativas del pasado y literatura infantil: continuidades y rupturas en los planteos críticos de Graciela Montes y Ana Maria Machado

    Directory of Open Access Journals (Sweden)

    Laura Rafaela García

    2015-01-01

    Full Text Available Este trabajo propone continuar los estudios iniciados en otras instancias de investigación con el fin de explorar la literatura infanto - juvenil desde los estudios literarios y el impacto de la violencia política de las últimas dictaduras militares. El texto recorrerá l as miradas del pasado a partir de la experiencia de dos autoras claves para la literatura infantil de Argentina y de Brasil, como son Graciela Montes y Ana Maria Machado. Por un lado, este estudio pretende profundizar en los modos en los que la violencia p olítica de la última dictadura incidió en las prácticas intelectuales de estas autoras en los dos países. Esto nos permitirá establecer similitudes y diferencias entre ambos casos. Por otro lado, avanzaremos en el análisis de narrativas críticas entendidas como memorias fundamentales para la reconstrucción de las polémicas que definieron los principales planteos de la literatura para niños en los años noventa, dentro del contexto democrático. El posicionamiento crítico de las autoras con respecto a los movi mientos de su campo y las características del contexto de cada país contribuye a profundizar en los modos desde los cuales la literatura participa de la infancia.

  20. História da química e da geologia: Joseph Black e James Hutton como referências para educação em ciências History of chemistry and geology: Joseph Black and James Hutton as references for science education

    Directory of Open Access Journals (Sweden)

    Natalina Aparecida L. Sicca

    2002-07-01

    Full Text Available The second half of eighteenth century is marked by the advancement of chemistry and geology. The first science acquired the law of conservation of mass and this science represented a important support to geology and mineralogy. We say that both became modern science that time. Our aim is to show up some interrelations between history of chemistry and history of geology by means of the study of Joseph Black's and James Hutton's works. We defend that it is positive to science education to understand and approach the relations among different and disciplinary areas of science.

  1. Romantic Joseph Lenné Landscape Park in Zatonie Near Zielona Góra as a Relic of Garden Art - Modern-Day Transformations and Threats

    Directory of Open Access Journals (Sweden)

    Kochańska Agnieszka

    2016-09-01

    Full Text Available The romantic landscape park was established in 1824 by order of one of the best-known aristocrats at the time, Princess Dorothea Talleyrand Perigold, Dutchess of Dino. The park is an example of amenity horticulture of artistic value that has survived to this day. The creator of the park was the talented landscape architect Peter Joseph Lenné.

  2. Operatic films: a comparative study of Don Giovanni by Joseph Losey and Juan by Kasper Holten

    Directory of Open Access Journals (Sweden)

    Isabel VILLANUEVA BENITO

    2017-12-01

    Full Text Available From an artistic point of view, the adaptation of an opera to the cinema, traditionally has been considered a complex and controversial process. Don Giovanni, of W.A. Mozart is one of the operas that more audiovisual versions has generated during the centuries XX and XXI, although very few films have finally been taken to the screen. This paper is focused on comparing the audiovisual versions Don Giovanni, by Joseph Losey (1979, and Juan by Kasper Holten (2010. Through a quantitative and qualitative methodology based on content analysis, this research reflects on the degree of intervention exercised by the language and audiovisual format used in the process of reinterpretation of the pre-existing operatic text.

  3. Studies on Instabilities in Long-Baseline Two-Way Satellite Time and Frequency Transfer (TWSTFT) Including a Troposphere Delay Model

    Science.gov (United States)

    2007-11-01

    281.4 -281.2 -281.0 MJD 54270.0 to 54277.0 (June 2007) MJD 53767.0 to 53773.0 (Feb 2006) S ag na c de la y N IC T to P TB (n s) days from MJD...standards in Europe and the US at the 10-15 uncertainty level,” Metrologia , 43, 109-120. [2] D. Piester, A. Bauch, L. Breakiron, D. Matsakis, B...Blanzano, and O. Koudelka, 2008, “Time transfer with nanosecond accuracy for the realization of International Atomic Time,” submitted to Metrologia

  4. As questôes constitucionais do império: O contexto jurídico e político refletido nos contos 'Fulano' e 'Un homem célebre', de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Tito Lívio Cabral Renovato Silva

    2015-10-01

    Full Text Available Este trabalho tem por objetivo analisar as questões constitucionais que ocorreram na segunda metade do século XIX, a exemplo da “questão religiosa”, “questão militar” e “abolição da escravatura”, que levaram ao fim do regime monárquico no Brasil. Iremos tratar do panorama histórico da época, a ordem jurídica vigente e as crises constitucionais do Império, onde analisaremos a Constituição de 1824 e seus artigos que abordam da divisão dos poderes e das funções concernentes ao Poder Moderador. Analisaremos todas essas questões através da visão de Machado de Assis refletida nos personagens dos contos “Fulano” e “Um homem célebre”, sob um ponto de vista interdisciplinar entre o Direito e a Literatura.

  5. Evaluation of in-situ methanotrophic bioremediation for contaminated groundwater, St. Joseph, Michigan. Final report, January 1989-December 1989

    International Nuclear Information System (INIS)

    McCarty, P.L.; Semprini, L.; Dolan, M.E.; Harmon, T.C.; Just, S.

    1990-09-01

    A feasibility study of utilizing indigenous bacteria that use methane as a source of cell carbon and energy (methanotrophs) for in-situ bioremediation of groundwater contaminants at the St. Joseph site is summarized. The contaminants, compounds, can be biotransformed by methanotrophic bacteria, which are found in some locations of the site in adequate populations. The process involves stimulating the growth of native populations of methanotrophs by injecting water containing dissolved methane and oxygen into the aquifer. The stimulated population of methanotrophs in turn has the capability to degrade trichloroethylene, 1,2-cis-dichloroethylene, 1,2-trans-dichloroethylene, and vinyl chloride

  6. War, sanity, and the Nazi mind: the last passion of Joseph Jastrow.

    Science.gov (United States)

    Behrens, Peter J

    2009-11-01

    The career of Joseph Jastrow (1863-1944) spanned more than 50 years in service to psychology. For 40 years he represented academic psychology at the University of Wisconsin as chair of the psychology department (1886 to 1927), but also was never far from popularizing psychology through books, articles, public lectures, newspaper columns, and finally radio lectures (e.g., Jastrow, 1900, 1935b). Providing a scientific and progressive psychology for the general public was always a strong penchant for Jastrow on several subjects, such as spiritualism (Jastrow, 1911) and effective living (Jastrow, 1935b). About 1939, while he was well into his 70s, his efforts focused on exposing the menace that Adolf Hitler and Nazism posed, so he undertook to enlist prominent editors to publish his work, Hitler: Mask and Myth, as articles or a book. He was not successful in gaining support for the project. His failing can be understood from the perspectives of the American market for Hitler material, the shortcomings of the manuscript, and how he represented psychology to the American public.

  7. Resident fish stock status above Chief Joseph and Grand Coulee dams : 2000 annual report; ANNUAL

    International Nuclear Information System (INIS)

    Lockwood, N.; McLellan, J.; Crossley, B.

    2001-01-01

    The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, commonly known as the Joint Stock Assessment Project (JSAP) is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (blocked area). The three-phase approach of this project will enhance the fisheries resources of the blocked area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information housed in a central location will allow managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP (NWPPC program measure 10.8B.26) is designed and guided jointly by fisheries managers in the blocked area and the Columbia Basin blocked area management plan (1998). The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of blocked area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the blocked area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. The use of common collection and analytical tools is essential to the process of streamlining joint management decisions. In 1999 and 2000 the project

  8. Aspects sociaux et religieux dans l’anthropologie pédagogique de Joseph Wresinski (Social and religious aspects in Joseph Wresinski’s pedagogical anthropology

    Directory of Open Access Journals (Sweden)

    Gabriella Kiss

    2016-12-01

    Full Text Available Joseph Wresinski founded the ATD-Fourth World Movement in France in 1957 with the aim of eradicating poverty, as well as the exclusion and the lack of rights that go with it, in order to be able to model the structure of a society that has the most disadvantaged people in its centre. As an ordained priest of the Catholic Church, he created a secular organisation whose practice and ensuing principles are shaped by this peculiar duality. In order to demonstrate this facet, the first part of the present study gives a brief overview of Wresinski’s career, highlighting how the personal aspects of his life had influenced his views concerning the poorest, and more specifically, the principles and objectives of the Movement he founded. Thereafter, I address the particularities of the Movement, emphasizing its religious and social dimensions, in relation to the secular nature of French society. The two subchapters of the third part describe the two factors of the primordial relationship that constitutes the two, interdependent pillars of the Movement, emphasizing the relevant features of Wresinski’s vision concerning the poorest and also the volunteers engaged in the Movement. Finally, I intend to show how the pedagogical anthropology of Wresinski, with his radical interpretation of the Gospel, positions in its centre the man who, disfigured by poverty, is still the most authentic bearer of universal humanity, as he inseparably incorporates human rights and the divine filiation.

  9. SCHOOL CONTEXT AND DANCE IN COLLECTIVE: CASE STUDY IN STATE COLLEGE MACHADO DE ASSIS

    Directory of Open Access Journals (Sweden)

    Tainã Silva Oliveira

    2015-12-01

    Full Text Available This research of a case study in State College Machado de Assis - CEMA, in order to analyze the school context and the reality of this dance school. The research is linked to the Institutional Program Initiation Purse in Teaching - PIBID, performed by scholarship students of the Bachelor's Degree in Dance at the Federal Institute of Education, Science and Technology -IFG Goiás, Campus Aparecida de Goiânia - Goiás. From analysis of diagnostic, highlighted the need to investigate and analyze a project of this school, that it is the creation and actions of a dance group called Danç'art. The methodology of the research, theoretical and field, permeated by the study authors and researchers that supported and provoked reflections. Brings inherent notes related to the school context which helps to think about the dance by the bias of a critical overview. For greater understanding of the school context were made questionnaires for students, for dance teacher, teachers of other subjects besides the director and coordinators. These studies validate and enable greater understanding of the need for experience and expansion looks about the dance school. From the field research through observations and interviews applied by scholars, we can see a devaluation by managers and teachers from other areas, which unfolds into challenges and contradictions, so that actions aimed at dance to expand and efetivem critically and consistently. Another objective is to cause a provocation and investigate the reality of dance in this context, from the following questions: what prompted the dance teacher to create the group and what look professional regarding the teaching of dance? What is the perception and interest of students to participate and be part of the group? What is an interactive dance and what is its importance in the perspective of a group of dance? How to give the processes of teaching, creation and testing of the group? Understanding the design of this

  10. Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.

    Directory of Open Access Journals (Sweden)

    Erik Kvam

    2009-05-01

    Full Text Available Misfolding- and aggregation-prone proteins underlying Parkinson's, Huntington's and Machado-Joseph diseases, namely alpha-synuclein, huntingtin, and ataxin-3 respectively, adopt numerous intracellular conformations during pathogenesis, including globular intermediates and insoluble amyloid-like fibrils. Such conformational diversity has complicated research into amyloid-associated intracellular dysfunction and neurodegeneration. To this end, recombinant single-chain Fv antibodies (scFvs are compelling molecular tools that can be selected against specific protein conformations, and expressed inside cells as intrabodies, for investigative and therapeutic purposes.Using atomic force microscopy (AFM and live-cell fluorescence microscopy, we report that a human scFv selected against the fibrillar form of alpha-synuclein targets isomorphic conformations of misfolded polyglutamine proteins. When expressed in the cytoplasm of striatal cells, this conformation-specific intrabody co-localizes with intracellular aggregates of misfolded ataxin-3 and a pathological fragment of huntingtin, and enhances the aggregation propensity of both disease-linked polyglutamine proteins. Using this intrabody as a tool for modulating the kinetics of amyloidogenesis, we show that escalating aggregate formation of a pathologic huntingtin fragment is not cytoprotective in striatal cells, but rather heightens oxidative stress and cell death as detected by flow cytometry. Instead, cellular protection is achieved by suppressing aggregation using a previously described intrabody that binds to the amyloidogenic N-terminus of huntingtin. Analogous cytotoxic results are observed following conformational targeting of normal or polyglutamine-expanded human ataxin-3, which partially aggregate through non-polyglutamine domains.These findings validate that the rate of aggregation modulates polyglutamine-mediated intracellular dysfunction, and caution that molecules designed to

  11. Laparoscopic Scar: a mimicker of Sister Mary Joseph's nodule on positron emission tomography/CT

    International Nuclear Information System (INIS)

    Setty, B.; Blake, M.A.; Holalkere, N.S.; Blaszkowsky, L.S.; Fischman, A.

    2006-01-01

    Positron emission tomography/CT is an established imaging method in the diagnosis and staging of cancers. 18 F -fluoro-2-deoxy-D-glucose (FDG) is the most commonly used radiotracer in positron emission tomography/CT. It is a tumour viability agent and usually its uptake within a lesion reflects the presence of a viable tumour tissue. However, false-positive FDG uptake is known to occur in benign processes of either inflammatory or infectious aetiology. We describe FDG uptake at the site of laparoscopic scar that mimicked Sister Mary Joseph's nodule in a patient with gastric adenocarcinoma. Here, the knowledge of the patient's history and subtle imaging findings helped in accurate staging of the patient. In this case report, we emphasize the value of the knowledge of the patient history and awareness of different pitfalls of FDG to achieve a correct diagnosis on positron emission tomography/CT

  12. Noise Performance Evaluation of the Candidate Digitizers for the MAJORANA DEMONSTRATOR

    Energy Technology Data Exchange (ETDEWEB)

    Aguayo Navarrete, Estanislao

    2011-03-16

    The noise performance evaluation of the two digitizer cards being considered for the MAJORANA DEMONSTRATOR (MJD) is presented in this document. The procurement of the data acquisition electronics for the MJD is scheduled to happen this year. At the time of writing this document, there are two candidate digitizer electronic boards. One aspect that is being considered by the collaboration is the feasibility of using the MJD for dark matter searches. The feasibility of using the MJD for this application is going to be dictated by the ability of the demonstrator to reach sub-keV energy resolution. One of the potential sources of noise in the MJD is the data acquisition system. This document will is concluded with a recommendation for the final digitizer board by comparing the noise performance of the two electronics systems. Noise parameters such as the effective number of bits, input range linearity and signal to noise ratio are experimentally determined. The two digitizer cards feature different on-board digital signal processing and these features are compared. The experimental set-up was also used to identify sources of noise. This paper describes these sources of noise in the data acquisition system, along with mitigation strategies. Issues such as grounding and wiring scheme have an impact in the overall data acquisition system performance and are discussed in detail. As a conclusion, the suitability of each one of the cards to become the back bone of the data acquisition system of the MJD is discussed.

  13. Joseph Roth in den Niederlanden und Flandern: Vermittlung, Vernetzung und Orchestierung eines vielseitigen Autors im niederländischsprachigen Kontext 1924-1940

    OpenAIRE

    Snick, E.S.

    2011-01-01

    This dissertation investigates the contemporary mediators and networks that played an important role in the canonization of Joseph Roth’s (original and translated) work in Flanders and the Netherlands. These mediators and networks made a substantial contributionto Roth’s intellectual and literary life (and were the key to his ‘survival’) in the period of his exile in these countries. The theoretical framework employed in this study is based on Von Dorleijn and van Rees’s views on the literary...

  14. Joseph Jacobs: Apprentice to Crawford W. Long in Athens, GA; Pharmacist and Retailer of Soda Fountain Beverages in Atlanta, GA.

    Science.gov (United States)

    Haridas, Rajesh P

    2018-01-01

    In the 1870s, Joseph Jacobs was employed as an apprentice in the Longs and Billups pharmacy in Athens, GA. Jacobs later established a chain of pharmacies in Atlanta, GA. Coca-Cola was first sold to the public on May 8, 1886, at Jacobs' Pharmacy in the Five Points district of Atlanta, GA. The soda fountain in Jacobs' Pharmacy was owned by Willis E. Venable, who was related to James M. Venable, the first patient etherized by Crawford Long in Jefferson, GA. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. José Ignacio Moreno. Un teólogo peruano. Entre Montesquieu y Joseph de Maistre

    Directory of Open Access Journals (Sweden)

    Victor Samuel Rivera

    2013-01-01

    Full Text Available José Ignacio Moreno es uno de los fundadores de la independencia del Perú. En calidad de tal acompañó el proyecto del General rioplatense José de San Martín de transformar en 1822 la monarquía peruana en un reino independiente. Pero, a diferencia de la multitud de sus contemporáneos, la historiografía apenas lo presenta como un circunstante en la epopeya de la emancipación, de quien no se conserva ni un retrato. El motivo es la extraña adherencia de este personaje a las ideas del ultramontanismo y su temprana cercanía con la obra del contrarrevolucionario francés Joseph de Maistre. Un discurso monárquico extremista en 1822 lo colocaría como el fundador involuntario del Perú como República.

  16. Handwerklicher Hintergrund und Perspektiven akademischer Studien. Zum Frühwerk Joseph Führichs in Böhmen

    Directory of Open Access Journals (Sweden)

    Machalíková, Pavla

    2013-11-01

    Full Text Available The study of the early works by Joseph Führich helps to elucidate his role in the formation of the national schools of painting as understood by the early 19th century. It also reveals the links between the academic schooling and paintings of the artist (regarded as one of the leading representatives of Romanticism in the early 1820s in Prague and his commissioned works of the period intended for more traditional clients and public – altar paintings for Northern Bohemian churches. An analysis of his most important paintings from around the mid-1820s indicates, that he managed to integrate various elements into highly specific personal style: craftsmanship acquired in his father's workshop, elements inspired by old art, academic schooling, and inspiration provided by contemporary Romantic art and iconography.

  17. Franz Joseph Gall and music: the faculty and the bump.

    Science.gov (United States)

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking. © 2015 Elsevier B.V. All rights reserved.

  18. CERN 50th Anniversary Official Celebration : welcome by CERN Director General Robert Aymar to French President Jacques Chirac, to King of Spain Juan Carlos and to President of the Swiss Confederation Joseph Deiss

    CERN Multimedia

    Patrice Loiez; Michel Blanc

    2004-01-01

    CERN 50th Anniversary Official Celebration : welcome by CERN Director General Robert Aymar to French President Jacques Chirac, to King of Spain Juan Carlos and to President of the Swiss Confederation Joseph Deiss

  19. Medical doctors as the captain of a ship: an analysis of medical students? book reports on Joseph Conrad?s ?Lord Jim?

    OpenAIRE

    Hwang, Kun; Lee, Seung Jae; Kim, Seong Yeon; Hwang, Se Won; Kim, Ae Yang

    2014-01-01

    Purpose: In South Korean ferry disaster in 2014, the captain abandoned the ship with passengers including high school students still aboard. We noticed the resemblance of abandoning the ship with passengers still aboard the ferry (named the Sewol) and the ship Patna, which was full of pilgrims, in Joseph Conrad’s novel “Lord Jim.” The aim of this study is to see how medical students think about the role of a medical doctor as a captain of a ship by analyzing book reports on Conrad’s “Lord Jim...

  20. Inpatient management of borderline personality disorder at Helen Joseph Hospital, Johannesburg

    Directory of Open Access Journals (Sweden)

    Laila Paruk

    2016-06-01

    Full Text Available Objective: The aim of this report was to establish a profile of patients with borderline personality disorder (BPD admitted to the acute inpatient psychiatric assessment unit at the Helen Joseph Hospital, in Johannesburg, over the course of 1 year. Methods: A retrospective record review was conducted to investigate the prevalence, demographics, reasons for admission, treatment, length of stay and follow-up of a group of inpatients during 2010 with a diagnosis of BPD, based on DSM-IV-TR diagnostic criteria, allocated on discharge. Results: Considering evidence retrospectively, the quality of the BPD diagnosis allocated appeared adequate. Statistical analysis revealed findings mainly in keeping with other reports, for example, that patients with BPD are above-average users of resources who make significantly more use of emergency services and that they generally do not adhere well to their scheduled outpatient follow-up arrangements. The longer average length of inpatient stay of this group with BPD, however, exceeded the typically brief period generally recommended for acute inpatient containment and emergency intervention. Conclusion: Implementation of targeted prevention and early intervention strategies, based on systematised programmes such as dialectical behavioural therapy and mentalisation based therapy, may be useful in addressing these problems experienced with integrating the in- and outpatient management of BPD. Keywords: Borderline personality; inpatient; acute

  1. "If I only touch her cloak": the Sisters of Charity of St. Joseph in New Orleans hospital, 1834-1860.

    Science.gov (United States)

    Kong, Hyejung Grace; Kim, Ock-Joo

    2015-04-01

    This study is about the Sisters of Charity of St. Joseph in New Orleans' Charity Hospital during the years between 1834 and 1860. The Sisters of Charity of St. Joseph was founded in 1809 by Saint Elizabeth Ann Bailey Seton (first native-born North American canonized in 1975) in Emmitsburg, Maryland. Seton's Sisters of Charity was the first community for religious women to be established in the United States and was later incorporated with the French Daughters of Charity of St. Vincent de Paul in 1850. A call to work in New Orleans' Charity Hospital in the 1830s meant a significant achievement for the Sisters of Charity, since it was the second oldest continuously operating public hospitals in the United States until 2005, bearing the same name over the decades. In 1834, Sister Regina Smith and other sisters were officially called to Charity Hospital, in order to supersede the existing "nurses, attendants, and servants," and take a complete charge of the internal management of Charity Hospital. The existing scholarship on the history of hospitals and Catholic nursing has not integrated the concrete stories of the Sisters of Charity into the broader histories of institutionalized medicine, gender, and religion. Along with a variety of primary sources, this study primarily relies on the Charity Hospital History Folder stored at the Daughters of Charity West Center Province Archives. Located in the "Queen city of the South," Charity Hospital was the center of the southern medical profession and the world's fair of people and diseases. Charity Hospital provided the sisters with a unique situation that religion and medicine became intertwined. The Sisters, as nurses, constructed a new atmosphere of caring for patients and even their families inside and outside the hospital, and built their own separate space within the hospital walls. As hospital managers, the Sisters of Charity were put in complete charge of the hospital, which was never seen in other hospitals. By

  2. Organización territorial en España y en Colombia. “Informe sobre España. Repensar el Estado o destruirlo”.Santiago Muñoz Machado

    Directory of Open Access Journals (Sweden)

    Catalina Ana Larach Del Castillo

    2013-12-01

    Full Text Available Teniendo en cuenta dos libros de reciente publicación, uno en España (Muñoz Machado, 2012 y otro en Colombia (Mendoza Martelo, 2013, se revela una preocupación en la organización territorial de ambos países. ¿Por qué decantarse por un modelo territorial? Errores comunes constitucionales en el ámbito territorial, crisis en el funcionamiento y coordinación entre los distintos niveles de gobierno, regiones, comunidades autónomas, reforma legal o cambio constitucional, son algunos de los asuntos que se debaten hoy en día y que están siendo motivo de evaluación. En la obra objeto de esta reseña se analizan los principales problemas por los que está atravesando España y se establecen propuestas para solucionarlos o disminuir su incidencia, revisando opciones como el retorno al centralismo, la conservación parcial de Comunidades Autónomas, la sustitución del modelo actual por un Estado federal, la autodeterminación y el separatismo. A partir del estudio propuesto, se equipararán algunos aspectos del sistema territorial colombiano para revisar su funcionamiento y necesidad o no de reformarlo.

  3. Monsters and the case of L. Joseph: André Feil's thesis on the origin of the Klippel-Feil syndrome and a social transformation of medicine.

    Science.gov (United States)

    Belykh, Evgenii; Malik, Kashif; Simoneau, Isabelle; Yagmurlu, Kaan; Lei, Ting; Cavalcanti, Daniel D; Byvaltsev, Vadim A; Theodore, Nicholas; Preul, Mark C

    2016-07-01

    André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance.

  4. The institution of science and the science of institutions the legacy of Joseph Ben-David

    CERN Document Server

    2014-01-01

    The present anthology, edited by Marcel Herbst, is partially based on a conference, held in 2009, to reflect on the legacy of Ben-David, and contains a selection of substantially revised papers, plus four contributions specifically written for this volume. The book focuses on three major lines of Ben-David’s research, namely “Center and Periphery” (Part I), “Role and Ethos” (Part II), and “Organization and Growth” (Part III). In addition, comprehensive introductory (“Prologue”) and concluding chapters (“Epilogue”, Part IV) by Marcel Herbst are provided. The volume addresses the following disciplines: higher education, history and sociology of science, philosophy of science, history of medicine, public administration, policy studies, Jewish studies, and economics. The anthology is one of two new publications on Joseph Ben-David after the special Minerva edition Vol. 25, Numbers 1–2, March 1987, and Gad Freudenthal’s collection of Ben-David’s writings [1991]. The text can be used i...

  5. Catherine the Great in the writings of Charles-Joseph Lamoral, 7th Prince de Ligne

    Directory of Open Access Journals (Sweden)

    Joanna Pychowska

    2012-01-01

    Full Text Available Charles-Joseph de Ligne (1735-1814, a Wallon and European Prince, subject of the Austro-Hungary Empire, a heartbreaker of the French Europe, is considered the most famous representative of literary cosmopolitanism. War, love and writing were inseparable in his life. He took part in numerous military campaigns, serving both Austria and Russia, as a Russian colonel, a commander of the order of Maria Theresa, and an Austrian fi eld marshal. He authored various texts related to war; he admired heroism of Charles II, Conde, the tactics of Frederick II, the strategies of Napoleon, Catherine II. The latter was immportalized in de Ligne’s various texts representing different literary genres. The Prince was clearly fascinated by the Empress, and he depicted her in a positive light as an educated person, both agreable and determined. Can we, however, talk about the documentary character of his work ? Instead, the Prince seems to be a documentalist-interpreter.

  6. Joseph Carpue's file drawer experiment – A murder mystery from 1801

    Directory of Open Access Journals (Sweden)

    M. Felix Freshwater

    2015-12-01

    Full Text Available Today unpublished or “file drawer” experiments are the impetus for trial registration and reporting of all results. In 1801, Joseph Carpue, the father of modern plastic surgery, did a file drawer experiment for Benjamin West, who was President of the Royal Academy of Arts. George III had commissioned West to create the largest stained glass window ever created whose theme, the Crucifixion, was based upon Michelangelo's drawing. Subsequently, West suffered a series of political, professional and economic setbacks. In the summer of 1801, West's project was delayed. By the fall, West hoped that independent scientific confirmation of his design could salvage the project. West approached Carpue who obtained a murderer's fresh corpse that he crucified and documented the results with plaster casts created by sculptor Thomas Banks. Carpue's experiment showed that West's window design wrongly depicted the Crucifixion because West had posed the hands and shoulders incorrectly. West died in 1820 without ever being associated with Carpue's experiment. Carpue's obituary in The Lancet in 1846 contained Carpue's handwritten note that described the experiment but not West's Royal commission. As no records or publications associate the cast with West project, this can be considered to be a file drawer experiment. After 1801, West made further drawings of the Crucifixion that showed the figures in the same position as the cast. Nineteenth century auction catalogues suggest that West made a corrected Crucifixion painting, but its current location remains a mystery.

  7. A "next generation" ethics committee. St. Joseph Health system has integrated performance-improvement features into its ethics work.

    Science.gov (United States)

    Murphy, Kevin

    2006-01-01

    Understanding the limitations that accompany the traditional model of ethics committees, St. Joseph Health System (SJHS), Orange, CA, has been working to integrate ethics expertise and quality-improvement methodology into its "Next Generation Model" (NG Model) for such committees. However, moving from a traditional structure to the NG Model (introduced to SJHS facilities in 1999) brought some challenges, not the least of which was a deep-rooted culture of resistance to change. Following a 2004 audit of how the NG model was working, some common challenges were identified. To deal with those challenges, SJHS developed some tools and techniques that have helped ease the ongoing transition. These tools have helped the system's ethics committees address such issues as collaboration for the sake of organizational integration, setting goals, and measuring performance of various ethics roles.

  8. Radio and X-Ray Observations of the 1998 Outburst of the Recurrent X-Ray Transient 4U 1630-47

    Science.gov (United States)

    Hjellming, R. M.; Rupen, M. P.; Mioduszewski, A. J.; Kuulkers, E.; McCollough, M.; Harmon, B. A.; Buxton, M.; Sood, R.; Tzioumis, A.; Rayner, D.; Dieters, S.; Durouchoux, P.

    1999-03-01

    We report radio (NRAO VLA and Australia Telescope Compact Array), soft X-ray (Rossi X-Ray Timing Explorer ASM), and hard X-ray (Compton Gamma Ray Observatory BATSE) observations of a 1998 outburst in the recurring X-ray transient 4U 1630-47, where radio emission was detected for the first time. The radio observations identify the position of 4U 1630-47 to within 1". Because the radio emission is optically thin with a spectral index of ~-0.8 during the rise, peak, and decay of the initial radio event, the emission is probably coming from an optically thin radio jet ejected over a period of time. The 20-100 keV emission first appeared 1998 January 28 (MJD 50841), the 2-12 keV emission first appeared 1998 February 3 (MJD 50847), and the first radio emission was detected 1998 February 12.6 (MJD 50856.6). The rise of the radio emission probably began about 1998 February 7 (MJD 50851) when the X-rays were in a very hard fluctuating-hardness state, just before changing to a softer, more stable hardness state.

  9. Diseño para la implementación de los procesos de talento humano para la Pyme Producomercio Joseph´s Foods

    OpenAIRE

    Alvarado Villarreal, Maria del Rocio

    2014-01-01

    La empresa Producomercio Joseph´s Foods, es una empresa de tipo familiar, actualmente está formando parte del sector de las PYMES, inició sus operaciones hace 47 años como una pequeña empresa artesanal, con el pasar del tiempo ha ido creciendo progresivamente, por lo que cada día precisa la contratación de más personal con especialización de funciones; el compromiso de sus directivos es ofrecer productos de la mejor calidad y con el mejor servicio, por ello para seguir operando y llegar a tra...

  10. Mountford Joseph Bramley: A pioneering thyroidologist and the first principal of Asia′s oldest medical college

    Directory of Open Access Journals (Sweden)

    Subhankar Chatterjee

    2015-01-01

    Full Text Available Mountford Joseph Bramley was one of the educationists whose sincere efforts are undeniable in the making of modern India. After achieving the Member of the Royal College of Surgeons diploma, he joined the Malta Garrison as a Hospital Assistant and was soon promoted to the rank of Assistant Surgeon of the Rifle Brigade. Following his arrival in India in 1826, he held several important medical posts in the British service. He was one of the early researchers to investigate the role of iodine in the causation of goitre. He was appointed as the first Principal of the Medical College of Bengal, the oldest medical college in Asia, in 1835. Bramley was an educationist from the very core of his heart, and he always wished for the betterment of his students. He died early at the age of 34 years. His legacy as a pioneer in the fields of medical education and endocrinology, specifically thyroidology, has largely been shrouded in a miasma of time.

  11. Polycyclic Aromatic Hydrocarbons in Fine Particulate Matter ...

    Science.gov (United States)

    This study measured polycyclic aromatic hydrocarbon (PAH) composition in particulate matter emissions from residential cookstoves. A variety of fuel and cookstove combinations were examined, including: (i) liquid petroleum gas (LPG), (ii) kerosene in a wick stove, (iii) wood (10% and 30% moisture content on a wet basis) in a forced-draft fan stove, and (iv) wood in a natural-draft rocket cookstove. LPG combustion had the highest thermal efficiency (~57%) and the lowest PAH emissions per unit fuel energy, resulting in the lowest PAH emissions per useful energy delivered (MJd). The average benzo[a]pyrene (B[a]P) emission factor for LPG was 0.842 µg/MJd; the emission rate was 0.043 µg/min. The highest PAH emissions were from wood burning in the natural-draft stove (209-700 µg B[a]P/MJd). PAH emissions from kerosene were significantly lower than those from the wood burning in the natural-draft cookstove, but higher than those from LPG. It is expected that in rural regions where LPG and kerosene are unavailable or unaffordable, the forced-draft fan stove may be an alternative because its emission factor (5.17-8.07 µg B[a]P/MJd) and emission rate (0.52-0.57 µg/min) are similar to kerosene (5.36 µg B[a]P/MJd and 0.45 µg/min). Compared with wood combustion emissions, LPG stoves emit less total PAH emissions and less fractions of high molecular weight PAHs. Relatively large variations in PAH emissions from LPG call for additional future tests to identify the major

  12. Time and Frequency Transfer Activities at NIST

    Science.gov (United States)

    2008-12-01

    differences. The graph shows data from MJD 54466 to MJD 54763 (January 1, 2008 to October 24, 2008). II.E. The Sistema Interamericano de...Metrologia (SIM) Time Network The Sistema Interamericano de Metrologia (SIM) consists of national metrology institutes (NMIs) located in the 34...designed to mitigate multipath signals. All SIM systems are connected to the Internet and upload their measurement results to Internet Web servers

  13. Comparison of estimated energy intake from 224-hour recalls and a seven-day food record with objective measurements of energy expenditure in children

    DEFF Research Database (Denmark)

    Rothausen, Berit Worm; Matthiessen, Jeppe; Groth, Margit Velsing

    2012-01-01

    % limits of agreement were 438 and 3.52 MJ/d for the 224-HDRs, and 5.90 and 2.94 MJ/d for the 7-dFR. Pearson correlation coefficients between EI and EE were 0.51 for EI224-HDR and 0.29 for EI7-dFR, respectively. The proportion classified in the same or adjacent quartiles was 76% for EI224-HDR and 73...

  14. 2036-IJBCS-Article-Joseph Djeugap Fovo

    African Journals Online (AJOL)

    hp

    Amorim L, Berger RD, Hau B. 1997. Angular leaf spot of beans: relationships between disease, healthy leaf area and yield. Phytopathology, 87: 506-515. Buruchara R, Mukankusi C, Kwasi A. 2010. Bean disease and pest identification and management. Handbooks for small-scale seed producers N° 04: Kampala, Uganda;.

  15. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2004-2005 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R.; McKinstry, C.; Cook, C. [Pacific Northwest National Laboratory

    2005-02-01

    This report documents a four-year study(a) to assess the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee (Oncorhynchus nerka kennerlyi) and rainbow trout (O. mykiss) at the entrance to the forebay of the third powerplant at Grand Coulee Dam. The work was conducted for the Bonneville Power Administration, U.S. Department of Energy, by Pacific Northwest National Laboratory (PNNL) in conjunction with the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes). In this report, emphasis is placed on the methodology and results associated with the fourth project year and compared with findings from the previous years to provide an overall project summary. Since 1995, the Colville Confederated Tribes have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power and Conservation Council Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph dams on the Columbia River (Figure S.1). A 42-month investigation from 1996 to 1999 determined that from 211,685 to 576,676 fish, including kokanee and rainbow trout, were entrained annually at Grand Coulee Dam. Analysis of the data found that 85% of the total entrainment occurred at the dam's third powerplant. Because these entrainment rates represent a significant loss to the tribal fisheries upstream of the dam, they have been judged unacceptable to fishery managers responsible for perpetuating the fishery in Lake Roosevelt. In an effort to reduce fish entrainment rates, the scope of work for the Chief Joseph Kokanee Enhancement Project was modified in 2001 to include a multiyear study of the efficacy of using strobe lights to deter fish from entering the third powerplant forebay. Pacific Northwest National Laboratory initiated the four-year study in collaboration with Colville

  16. Post-Colonial Analysis of Joseph Conrad’s Heart of Darkness

    Directory of Open Access Journals (Sweden)

    Samet Güven

    2013-07-01

    Full Text Available Joseph Conrad’s Heart of Darkness tells the journey of Marlow through the African jungle and his search for the European Kurtz who exploits the natives by imposing violence. It is mainly based upon Conrad’s own experience in Congo. Conrad learned how Europeans exploited and traded the natives for their own benefits during his own journey. The book is regarded as an attack on imperialism and criticizes immoral treatments of the European colonizers in Africa in the 19th century. Keith Booker states that “the book deals with issues such as imperialism, capitalism, race, and gender that were very much at the forefront of the turn-of-the century European mind. Conrad’s ambivalent treatment of these issues is extremely representative of the way they were treated in any number of European discourses of the time” (217. Besides, Chinua Achebe in his An “Image of Africa: Racism in Conrad’s Heart of Darkness” comments that “Heart of Darkness projects the image of Africa as ‘the other world’, the antithesis of Europe and therefore of civilization, a place where man’s vaunted intelligence and refinement are finally mocked by triumphant bestiality” (338. Although Achebe puts forward that the novel is in favor of colonialism, I consider that Conrad does not intend to write it to appreciate colonialism and therefore the purpose of this study is to approach Conrad’s Heart of Darkness from post-colonial perspective by taking European imperialism and colonialism over Africa into consideration in order to clarify how Conrad has deconstructed binary oppositions of colonialism by subverting the general idea of the Europeans towards Africa in the 19th century.

  17. Post-Colonial Analysis of Joseph Conrad’s Heart of Darkness

    Directory of Open Access Journals (Sweden)

    Samet Güven

    2013-06-01

    Full Text Available Joseph Conrad’s Heart of Darkness tells the journey of Marlow through the African jungle and his search for the European Kurtz who exploits the natives by imposing violence. It is mainly based upon Conrad’s own experience in Congo. Conrad learned how Europeans exploited and traded the natives for their own benefits during his own journey. The book is regarded as an attack on imperialism and criticizes immoral treatments of the European colonizers in Africa in the 19th century. Keith Booker states that “the book deals with issues such as imperialism, capitalism, race, and gender that were very much at the forefront of the turn-of-the century European mind. Conrad’s ambivalent treatment of these issues is extremely representative of the way they were treated in any number of European discourses of the time” (217. Besides, Chinua Achebe in his An “Image of Africa: Racism in Conrad’s Heart of Darkness” comments that “Heart of Darkness projects the image of Africa as ‘the other world’, the antithesis of Europe and therefore of civilization, a place where man’s vaunted intelligence and refinement are finally mocked by triumphant bestiality” (338. Although Achebe puts forward that the novel is in favor of colonialism, I consider that Conrad does not intend to write it to appreciate colonialism and therefore the purpose of this study is to approach Conrad’s Heart of Darkness from post-colonial perspective by taking European imperialism and colonialism over Africa into consideration in order to clarify how Conrad has deconstructed binary oppositions of colonialism by subverting the general idea of the Europeans towards Africa in the 19th century.

  18. Current approaches to the treatment of Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Joseph Jankovic

    2008-09-01

    Full Text Available Joseph Jankovic, L Giselle AguilarParkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of MedicineAbstract: Enormous progress has been made in the treatment of Parkinson’s disease (PD. As a result of advances in experimental therapeutics, many promising therapies for PD are emerging. Levodopa remains the most potent drug for controlling PD symptoms, yet is associated with significant complications such as the “wearing off” effect, levodopa-induced dyskinesias and other motor complications. Catechol-o-methyl-transferase inhibitors, dopamine agonists and nondopaminergic therapy are alternative modalities in the management of PD and may be used concomitantly with levodopa or one another. The neurosurgical treatment, focusing on deep brain stimulation, is reviewed briefly. Although this review has attempted to highlight the most recent advances in the treatment of PD, it is important to note that new treatments are not necessarily better than the established conventional therapy and that the treatment options must be individualized and tailored to the needs of each individual patient.Keywords: Parkinson’s disease, levodopa, medical treatment, pallidotomy, deep brain stimulation

  19. OAS :: Authorities : Permanent Representatives to the OAS

    Science.gov (United States)

    Rights Actions against Corruption C Children Civil Registry Civil Society Contact Us Culture Cyber Representative of Belize Diego Pary Rodríguez Bolivia Diego Pary Rodríguez Ambassador, Permanent Representative of Bolivia José Luiz Machado Brazil José Luiz Machado e Costa Ambassador, Permanent Representative

  20. Moral absolutism and the double-effect exception: reflections on Joseph Boyle's Who is entitled to double effect?

    Science.gov (United States)

    Donagan, A

    1991-10-01

    Joseph Boyle raises important questions about the place of the double-effect exception in absolutist moral theories. His own absolutist theory (held by many, but not all, Catholic moralists), which derives from the principles that fundamental human goods may not be intentionally violated, cannot dispense with such exceptions, although he rightly rejects some widely held views about what they are. By contrast, Kantian absolutist theory, which derives from the principle that lawful freedom must not be violated, has a corollary--that it is a duty, where possible, to coerce those who try to violate lawful freedom--which makes superfluous many of the double-effect exceptions Boyle allows. Other implications of the two theories are contrasted. Inter alia, it is argued that, in Boyle's theory, that a violation of a fundamental human good can be viewed as a cost proportionate to a benefit obtained, cannot yield a double-effect exception to the prohibition of intentionally violating that good, because paying a cost cannot be unintentional.

  1. Joseph John Thomson's models of matter and radiation in the early 1890s.

    Science.gov (United States)

    Bordoni, Stefano

    In the late nineteenth century, Joseph John Thomson moved away from Maxwell's specific theoretical models of matter and energy, even though he continued to rely on the general framework of Maxwell's electromagnetic theory. In his 1893 book, he accomplished the conceptual drift towards a discrete model for matter, electricity, and fields. In Thomson's model, energy was linked to tubes of force, in particular to the aether contained in them and surrounding them: the energy was the kinetic energy of aether, of both a rotational and translational kind. Starting from Maxwell's electromagnetic fields, namely stresses propagating through a continuous solid medium, Thomson arrived at a representation of fields as a sea of discrete units carrying energy and momentum. He tried to transform Maxwell's theory into a unified picture in which atomic models of matter stood beside atomic models of fields. In 1904 his interpretation of X-rays was based on the integration between two complementary features of electromagnetic radiation, the continuity and the discreteness, and on some kind of fibrous aether. In recent secondary literature, the problematic conceptual link between J. J. Thomson's theory and contemporary theories on electromagnetic radiation has been underestimated. On the contrary, in the first half of the twentieth century, some physicists inquired into that link, and a widespread debate emerged, misunderstandings included.

  2. Three pioneers of comparative psychology in America, 1843-1890: Lewis H. Morgan, John Bascom, and Joseph LeConte.

    Science.gov (United States)

    Johnston, Timothy D

    2003-02-01

    Scientific comparative psychology in America dates from the mid-1890s, but there is a body of earlier literature on the topic, written during a period of theistic debates over Darwinian evolution. The anthropologist Lewis H. Morgan rejected instinct as an explanation of animal behavior in 1843 and defended the mental similarities between animals and humans, although he was not an evolutionist. John Bascom's textbook Comparative Psychology (1878) is the earliest American work to use that title, and its theistic approach anticipates some arguments found in much later evolutionary works. Beginning in 1860, the geologist Joseph LeConte, who is well known for defending the compatibility of evolution and religion, wrote several articles in which he outlined a comparative evolutionary approach to psychological problems. However, these writers did not establish a coherent research tradition and were ignored by the "New Psychologists" of the 1880s.

  3. Safety and efficacy of iron supplementation in pregnant Kenyan women

    NARCIS (Netherlands)

    Mwangi, M.N.

    2014-01-01

    Since the British doctor Ronald Ross received the 1902 Nobel Prize in medicine for his work on malaria, more people have died from the disease than all world wars combined. This is in spite of the fact that the French chemists Pierre Joseph Pelletier and Joseph Bienaimé Caventou made quinine

  4. Educação integral: notas sobre Charles Fourier, Saint Simon e Pierre-Joseph Proudhon

    Directory of Open Access Journals (Sweden)

    José Damiro Moraes

    2015-11-01

    Full Text Available Este artigo procura contribuir para as discussões em torno do conceito histórico de educação integral, tendo em vista que existem algumas lacunas em torno desse tema. Aqui iremos abordar os conceitos de educação integral no pensamento dos intelectuais: Claude-Henri de Rouvroy ou Conde de Saint-Simon (1760-1825, François Marie Charles Fourier (1772-1837 e Pierre-Joseph Proudhon (1809-1865. A pesquisa utiliza as obras dos autores escritas/publicadas no século XIX. A metodologia procura entender a produção intelectual de maneira dialética e dentro do contexto histórico em que foi produzida. Indicamos como conclusões que Proudhon, Saint-Simon e Charles Fourier, consideravam no processo educacional que a parte literária estaria diretamente vinculada com a científica, unindo teoria e prática. Podemos aventar que as contribuições desses pensadores foram importante nas reflexões educacionais e na defesa de uma educação comprometida com a transformação social presente no pensamento socialista e no movimento operário do século XIX e XX.

  5. Chief Joseph Kokanee Enhancement Project : Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at Grond Coulee Dam Third Powerplant Forebay.

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, M.A.; McKinstry, C.A.; Simmons, C.S.

    2002-01-01

    Since 1995, the Colville Confederated Tribes have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council's (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation concluded that entrainment at Grand Coulee Dam ranged from 211,685 to 576,676 fish annually. Further analysis revealed that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC's Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the first year of the study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory (PNNL). The objective of the study was to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout. Analysis of the effect of strobe lights on the distribution (numbers) and behavior of kokanee and rainbow trout was based on 51, 683 fish targets detected during the study period (June 30 through August 1, 2001). Study findings include the following: (1) Analysis of the count data indicated that significantly more fish were present when the lights were on compared to off. This was true for both the 24-hr tests as well as the 1-hr tests. Powerplant discharge, distance from lights, and date were significant factors in the analysis. (2) Behavioral results indicated that fish within 14 m of the lights were trying to avoid the lights by swimming across the lighted

  6. Primary Immune Deficiency Disease Genetics & Inheritance

    Science.gov (United States)

    ... types of inherited mutations can cause PIDDs. Autosomal Dominant Credit: National Library of Medicine In this example, ... Hill, Ph.D. History Dr. Joseph J. Kinyoun: Father of the NIH Kinyoun: NIH Podcast – July 2012 ...

  7. Winston Churchill (1874-1965), Dr Robson Roose, MD Brux, FRCPE (1848-1905) and Dr Joseph Rutter, MD Lond, MRCP (1834-1913): Treatment for pneumonia in March 1886.

    Science.gov (United States)

    Vale, J Allister; Scadding, John W

    2018-01-01

    This paper will review Winston Churchill's severe respiratory illness in March 1886 when he developed pneumonia of the right lung as an 11-year-old boy. Winston was treated supportively with 'nourishment, stimulants [probably alcohol] and close watching' at his school by the 'celebrated' family physician, Dr Robson Roose, with the assistance of Dr Joseph Rutter. Roose was exemplary in his commitment to his young patient and assiduous in informing Lord Randolph Churchill of his son's clinical progress by letter.

  8. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2002-2003 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R.; McKinstry, C.; Simmons, C. (Pacific Northwest National Laboratory)

    2003-01-01

    Since 1995, the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes) have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation concluded that entrainment at Grand Coulee Dam ranged from 211,685 to 576,676 fish annually. Further analysis revealed that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the second year of the study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory. The 2002 study period extended from May 18 through July 30. The objective of the study was to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout. The prototype system consisted of six strobe lights affixed to an aluminum frame suspended vertically underwater from a barge secured in the center of the entrance to the third powerplant forebay. The lights, controlled by a computer, were aimed to illuminate a specific region directly upstream of the barge. Three light level treatments were used: 6 of 6 lights on, 3 of 6 lights on, and all lights off. These three treatment conditions were applied for an entire 24-hr day and were randomly assigned within a 3-day block throughout the study period. A seven

  9. Saberes e experiências na escola do campo - Uma entrevista com Ilma Ferreira Machado

    Directory of Open Access Journals (Sweden)

    Ivone Cella da Silva

    2016-12-01

    Full Text Available A proposição desta edição da Revista Eventos Pedagógicos apresenta a discussão acerca da educação do campo, “pois as coisas não querem mais ser vistas por pessoas razoáveis: Elas desejam ser olhadas de azul - Que nem criança que você olha de ave. Um olhar de ave, um olhar de azul é um simples olhar com mais atenção”. Assim, compartilhamos com os leitores e as leitoras a entrevista com a professora Ilma Ferreira Machado da Universidade do Estado de Mato Grosso (UNEMAT que é graduada em Pedagogia pela Universidade Federal de Mato Grosso com Mestrado e Doutorado em Educação pela Universidade Estadual de Campinas e Pós-doutorado pela Universidade Federal de Santa Catarina. Sua exemplar trajetória profissional na Educação Superior inclui papéis como professora do Curso de Pedagogia Para Educadores do Campo da UNEMAT/Sinop, do Curso de Pedagogia e de Mestrado em Educação da UNEMAT/Cáceres e como Reitora  da instituição. Com dedicação e militância pelas causas dos Movimentos Sociais, coordena o Projeto de Pesquisa “Desenvolvimento e Fortalecimento Científico-Tecnológico da Juventude Camponesa do Ensino Médio da Escola Estadual Madre Cristina no Assentamento Roseli Nunes - Mirassol Do Oeste – MT” e o Projeto de Extensão “Educação do Campo: currículo, formação de professores, docência e pedagogia da alternância”. No intuito de contribuir, dada a vasta experiência em educação, atua como membro do Conselho Editorial da Revista da Faculdade de Educação/UNEMAT. Seus estudos também abordam os temas: projeto político pedagógico; avaliação-ensino, avaliação processual; organização do trabalho pedagógico, educação do campo, educação e trabalho coletivo e a educação dos trabalhadores rurais. Com alegria, agradecemos pela oportunidade em entrevistá-la, ressaltando que aceitou prontamente o desafio de apresentar e discutir acerca de suas percepções e evidenciar os avanços e

  10. A question of merit: John Hutton Balfour, Joseph Hooker and the 'concussion' over the Edinburgh chair of botany.

    Science.gov (United States)

    Bellon, Richard

    2005-03-01

    In 1845, Robert Graham's death created a vacancy for the traditionally dual appointment to the University of Edinburgh's chair of botany and the Regius Keepership of the Edinburgh Royal Botanic Garden. John Hutton Balfour and Joseph Hooker emerged as the leading candidates. The contest quickly became embroiled in long running controversies over the nature and control of Scottish university education at a time of particular social and political tension after a recent schism in Church of Scotland. The politics of the appointment were complicated by the fact that the Edinburgh Town Council (which preferred Balfour) chose the chair while the keepership was under the patronage of the Westminster government (which preferred Hooker). Balfour eventually emerged triumphant after a bitter campaign marked on all sides by intense politicking. The struggle to replace Graham provides a case study in how Victorian men of science adapted their aspirations to the practical realities of life in industrial, reforming, imperial, multinational Britain.

  11. Identità, attraversamenti e ibridismi nell'opera di Joseph O'Connor

    Directory of Open Access Journals (Sweden)

    Manfredi Bernardini

    2011-05-01

    Full Text Available This paper looks into the works of Irish writer Joseph O’Connor and his perspective in the process of redefining the spacial, temporal and cultural links between Ireland and the Unites States. In fact, a number of interesting points can be found throughout O’Connor works: the imagology (the image of the Irishman in the American culture; the investigation on prejudices and stereotypes (True Believers, 1991; border studies, although considered in a broader sense, one where the physical and geographical borders (the Atlantic Ocean appear to be symbolic and imaginary. Referring to the concept of Black Atlantic, as it was first proposed by Paul Gilroy, we can similarly imagine - acording to scholars such as David Lloyd and Peter O’Neill - a Green Atlantic, where the Ocean, after ceasing to represent a frontier, a border meant to separate, acquires a new meaning and becomes a place for bidirectional crossing: on the one hand as a means to cross over borders and synthesis between two cultures; in the other as a movement towards and beyond the limits of a Third Space, “a space of enunciation” and cultural negotiation, as Homi Bhabha would say. Other fundamental and recurring themes in the novels of O’Connor are identity and memory (Sweet Liberty Travels in Irish America, 1996, the “look” of the Others (Inishowen, 2000 and towards the Other (Redemption Falls, 2007 and, more importantly, the Irish diaspora towards the United States, spanning from the final years of the 19th century until the first half of the 20th, when, in some respect, the United States were looked upon as a “promised land” (this is mostly evident in the novel Star of the sea, 2002.

  12. Romantic Joseph Lenné Landscape Park in Zatonie Near Zielona Góra as a Relic of Garden Art - Modern-Day Transformations and Threats

    Science.gov (United States)

    Kochańska, Agnieszka

    2016-09-01

    The romantic landscape park was established in 1824 by order of one of the best-known aristocrats at the time, Princess Dorothea Talleyrand Perigold, Dutchess of Dino. The park is an example of amenity horticulture of artistic value that has survived to this day. The creator of the park was the talented landscape architect Peter Joseph Lenné. In its current state, the park differs significantly from the image on lithographs of the past. Upon carrying out field investigations and comparative studies, it was established that the maintained stand of tress holds high compositional value. The conclusions of the article define the current threats to the longevity of the park as well as highlighting the plan of revalorization works.

  13. Was the real Sherlock Holmes a pediatric surgeon?

    Science.gov (United States)

    Raffensperger, John

    2010-07-01

    This article reviews the pioneering efforts of Joseph Bell, the model for Sherlock Holmes, in the surgical care of children during the antiseptic era. I reviewed biographies of Sir Arthur Conan Doyle; the biography of Joseph Bell; his surgical textbook, Edinburgh Medical Journals; and the history of the Royal Edinburgh Hospital for Sick Children. Dr Bell was a colleague of Joseph Lister and one of the first surgeons to apply antiseptic methods to operations involving children. He was the surgeon appointed to the first surgical ward of the Royal Edinburgh Hospital for Sick Children; in that role, he cared for many children with surgical diseases. Dr Joseph Bell, by his compassion for children and his surgical skill, was indeed a pioneer pediatric surgeon. Copyright 2010 Elsevier Inc. All rights reserved.

  14. Ortodoxia y heterodoxia en la filosofía de Joseph de Maistre. Sus antecedentes y sus huellas en el pensamiento contrarrevolucionario español (1833-1936)

    OpenAIRE

    Fornés Murciano, Antonio

    2015-01-01

    Joseph de Maistre va ser un pensador original, d'una profunditat major de la que freqüentment se li concedeix i posseïdor, a més, d'una prosa excepcional. Aquest estudi pretén mostrar d'una banda que la seva filosofia i la seva lluita a favor de l'ortodòxia polític-religiosa neix, paradoxalment, de fonts obertament heterodoxes, i d'un altre costat que el seu discurs ideològic i antirevolucionari, nodrit per la força d'aquest ascendent, va influir de forma determinant en els apriorismes foname...

  15. Aql X-1 transition towards the soft (banana) state accompanied by radio/NIR detection

    Science.gov (United States)

    Sivakoff, G. R.; Miller-Jones, J.; Fox, O.; Linares, M.; Altamirano, D.; Russell, D.

    2009-11-01

    The currently active neutron star transient and atoll source Aql X-1 (Linares et al., ATEL #2288) has begun the transition from the hard (extreme island) state to the soft (banana) state (Rodriguez et al. ATEL #2299). This transition likely began around 2009 Nov 15 (MJD = 55150). The latest RXTE PCA observation (2009 Nov 17, MJD=55152.17+/-0.02, 2-60 keV fractional rms variability amplitude of ~11% for 0.1-10 Hz) indicates that the source is in the intermediate (island) state.

  16. La robe et les mortiers. Joseph-Marie de Villespassans, magistrat faux-monnayeur (1713

    Directory of Open Access Journals (Sweden)

    Mathieu Soula

    2011-12-01

    Full Text Available Au début du XVIIIe siècle, un magistrat toulousain, le conseiller de Villepassans, est soupçonné d’être à la tête d’un réseau de faux-monnayeurs. L’affaire est sensible pour le parlement, qui instruit directement l’affaire, car il s’agit de poursuivre l’un de ses membres. Un magistrat faux-monnayeur est en effet une « figure » criminelle qui trouble et pose question. Par contagion, la mauvaise renommée de Villepassans peut atteindre les autres conseillers et porter le discrédit sur une institution qui se définit comme « le vrai vengeur des crimes ». Dans ces conditions, comment le parlement traite-t-il l’affaire, et quelle figure criminelle appose-t-il à Villespassans ? L’étude de ce cas atypique peut ainsi aider à mieux comprendre l’enjeu de la construction d’une identité criminelle.In early 18th century, a magistrate of the parliament of Toulouse, Joseph-Marie de Villespassans, is suspected of being the leader of forgers of money. This case is highly dangerous for the parliament, who’s in charge. The culpability of the magistrate-forger can also touch the others magistrates, and the prestige of the institution to. So, in these conditions, how can the parliament manage this case? I this research, we’re trying to study this atypical case in the way the parliament built the culpability.

  17. Alpha Background Discrimination in the MAJORANA DEMONSTRATOR

    Science.gov (United States)

    Gruszko, Julieta; Majorana Collaboration

    2017-09-01

    The Majorana Demonstrator (MJD) searches for neutrinoless double-beta decay of 76Ge using arrays of high-purity germanium detectors. If observed, this process would have implications for grand-unification and the predominance of matter over antimatter in the universe. A problematic background in such large granular detector arrays is posed by alpha particles. In MJD, potential background events that are consistent with energy-degraded alphas originating on the passivated detector surface have been observed. We have studied these events by scanning the passivated surface of a P-type point contact detector like those used in MJD with a collimated alpha source. We observe that surface alpha events exhibit high charge-trapping, with a significant fraction of the trapped charge being re-released slowly. This leads to both a reduced prompt signal and a measurable change in slope of the tail of a recorded pulse. In this contribution we discuss the characteristics of these events and the filter developed to identify the occurrence of this delayed charge recovery, allowing for the efficient rejection of passivated surface alpha events while retaining 99.8% of bulk events. We also discuss the impact of this filter on the sensitivity of MJD. This material is based upon work supported by the U.S. DOE, Office of Science, Office of Nuclear Phys., the Particle Astrophys. and Nuclear Phys. Programs of the NSF, and SURF. Additional support from the NSFGRFP under Grant No. 1256082.

  18. Joseph Priestley Across Theology, Education, and Chemistry: An Interdisciplinary Case Study in Epistemology with a Focus on the Science Education Context

    Science.gov (United States)

    de Berg, Kevin C.

    2011-07-01

    This paper discusses the findings of a search for the intellectual tools used by Joseph Priestley (1733-1804) in his chemistry, education, and theology documents. Priestley's enquiring democratic view of knowledge was applicable in all three areas and constitutes a significant part of his lifework. Current epistemological issues in science education are examined from the point of view of the nature of theory and experiment as observed in Priestley's writings and as espoused in modern philosophy of science. Science and religious faith issues in the context of science education are examined from the point of view of one's understanding of sacred texts, and the suggestion is made that a Priestleyan model of "the liberty to think for oneself" and "to hold knowledge with humility and virtue" could prove helpful in dealing with the known divergent opinions in relation to science, education, and religion.

  19. Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances

    Directory of Open Access Journals (Sweden)

    Scanlon SA

    2011-12-01

    Full Text Available Samantha A Scanlon1, Joseph A Murray1,21Department of Internal Medicine, 2Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USAAbstract: Celiac disease (CD is an immune-mediated enteropathy triggered by exposure to wheat gluten and similar proteins found in rye and barley that affects genetically susceptible persons. This immune-mediated enteropathy is characterized by villous atrophy, intraepithelial lymphocytosis, and crypt hyperplasia. Once thought a disease that largely presented with malnourished children, the wide spectrum of disease activity is now better recognized and this has resulted in a shift in the presenting symptoms of most patients with CD. New advances in testing, both serologic and endoscopic, have dramatically increased the detection and diagnosis of CD. While the gluten-free diet is still the only treatment for CD, recent investigations have explored alternative approaches, including the use of altered nonimmunogenic wheat variants, enzymatic degradation of gluten, tissue transglutaminase inhibitors, induction of tolerance, and peptides to restore integrity to intestinal tight junctions.Keywords: immune-mediated enteropathy, gliadin, gluten, epidemiology, CD diagnosis, therapy

  20. The orbital period in the supergiant fast X-ray transient IGR J16465--4507

    OpenAIRE

    Clark, D. J.; Sguera, V.; Bird, A. J; McBride, V. A.; Hill, A. B.; Scaringi, S.; Drave, S.; Bazzano, A.; Dean, A. J

    2010-01-01

    Timing analysis of the INTEGRAL-IBIS and Swift-BAT light curves of the Supergiant Fast X-ray Transient (SFXT) IGR J16465-4507 has identified a period of 30.32+/-0.02 days which we interpret as the orbital period of the binary system. In addition 11 outbursts (9 of which are previously unpublished) have been found between MJD 52652 to MJD 54764, all of which occur close to the region of the orbit we regard as periastron. From the reported flux outbursts, we found a dynamical range in the inter...

  1. Sauvegarde et valorisation du fonds d’archives familiales de Jean-Joseph Rabearivelo à Madagascar

    Directory of Open Access Journals (Sweden)

    Laurence Ink

    2014-04-01

    Full Text Available Figure essentielle et encore mal connue de la littérature malgache et internationale, Jean-Joseph Rabearivelo (1903‑1937 fut à la fois poète, journaliste et critique, dramaturge et romancier, historien de sa tradition, collecteur et traducteur de textes anciens comme de textes modernes. L’aventure qui débuta fin 2008 pour aboutir à la publication de ses œuvres complètes (AUF/ITEM, CNRS Éditions, Coll. Planète libre, Paris, 2 tomes, 2010 et 2012 consistait à sauvegarder l’important fonds d’archives familiales (plus de 800 manuscrits, tapuscrits, textes édités ou documents de travail confié par les ayant droits à l’Institut Français de Madagascar (Antananarivo, par un travail de tri, de numérisation et de mise en conditionnement neutre, in situ, et à le valoriser par l’édition des textes, pour une grande part inédits, dans une approche scientifique à caractère génétique. Expérience novatrice, structurée par une méthodologie devant constamment s’adapter aux exigences géographique, scientifique et éditoriale, elle est également à considérer comme un cas d’école, pour une meilleure approche des fonds d’archives littéraires, aujourd’hui en péril dans bon nombre de pays du Sud.

  2. L’intérêt historiographique des manuscrits de travail de linguistes : l’exemple de la linguistique générale de Joseph Vendryes

    Directory of Open Access Journals (Sweden)

    Testenoire Pierre-Yves

    2016-01-01

    Full Text Available Dans quelle mesure les manuscrits de travail des linguistes présentent-ils un intérêt pour les historiens de la linguistique ? Ce type de documents suscite, depuis quelques années, un regain indéniable de curiosité. L’exploration d’un nombre croissant de fonds d’archives de savants permet, au-delà d’un élargissement de l’horizon documentaire, d’envisager des approches comparatives entre différentes pratiques savantes. Elle ouvre aussi de nouvelles interrogations. Cet article réfléchit à l’intérêt historiographique de ce type de documents à partir d’un cas inédit : les papiers de travail consacrés à la linguistique générale du linguiste français, Joseph Vendryes (1875-1960. On met en évidence le double intérêt des archives privées de savants : documentaire et processuel. On aborde, dans un premier temps, les manuscrits d’un point de vue documentaire de façon à dégager ce que leur prise en compte modifie de notre connaissance de la linguistique générale de Joseph Vendryes. Le deuxième temps, consacré à la perspective processuelle, fait des manuscrits le lieu de l’observation de la méthode. Il s’agit d’analyser, à partir des manuscrits préparatoires à l’écriture d’un article, comment s’élabore un discours scientifique à caractère général sur le langage et les langues. Ces archives privées sont au carrefour de questionnements de recherche qui relèvent aussi bien d’une histoire conceptuelle que d’une histoire sociale des sciences du langage.

  3. The categories of the lyrical character and the material world in the Joseph Brodsky’s love poetry (the collection “The new stanzas to Augusta”: the interaction features

    Directory of Open Access Journals (Sweden)

    Bayramova Karina Arturovna

    2013-06-01

    Full Text Available This article is devoted to the problem of realization of the category of lyrical character in the Joseph Brodsky’s love poetry. The aspiration to characterize the lyrical character through details of the material world becomes the feature of the poet’s artistic worldview when the world of things symbolizes both emotional experiences of the character and his philosophy of creation. The vulnerability and finiteness of the material world in the late lyrics associate an inevitable end of physical existence of the character, but it consolidates the idea of creative immortality of love feeling.

  4. Effects of aerobic exercise and dietary carbohydrate on energy expenditure and body composition during weight reduction in obese women.

    Science.gov (United States)

    Racette, S B; Schoeller, D A; Kushner, R F; Neil, K M; Herling-Iaffaldano, K

    1995-03-01

    To test the benefits of aerobic exercise and dietary carbohydrate during reduced-energy feeding, 23 obese women (44 +/- 4% fat) were randomly assigned to either aerobic exercise (Ex) or no exercise (Nx), and to a low-fat (LF) or low-carbohydrate (LC) reducing diet (5.00 +/- 0.56 MJ/d) for 12 wk. Changes in body composition, postabsorptive resting metabolic rate (RMR), thermic effect of a meal (TEM), and total daily energy expenditure (TDEE) were measured by respiratory gas exchange and doubly labeled water. Significant effects of Ex included a greater loss of fat mass (Ex: -8.8 +/- 2.1 vs Nx: -6.1 +/- 2.3 kg, P = 0.008) and maintenance of TDEE (Ex: +0.07 +/- 1.23 vs Nx: -1.46 +/- 1.04 MJ/d, P = 0.004), due to a difference in physical activity (Ex: +0.75 +/- 1.06 vs Nx: -0.61 +/- 1.03 MJ/d, P = 0.006), which was not attributable solely to the Ex sessions. RMR in both groups decreased comparably (-0.54 MJ/d), and TEM (% of meal) did not change. Diet composition did not significantly influence body composition or energy expenditure changes, but a greater weight loss was observed after the LC than after the LF (-10.6 +/- 2.0 vs -8.1 +/- 3.0 kg, P = 0.037) diet. The addition of aerobic exercise to a low-energy diet was beneficial in the treatment of moderate obesity because of its favorable effects on body composition, physical activity, and TDEE.

  5. Resident Fish Stock above Chief Joseph and Grand Coulee Dams; 2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispel Department of Natural Resources, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife, Spokane, WA); Butler, Chris (Spokane Tribe of Indians, Department of Natural Resources, Wellpinit, WA)

    2003-09-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area

  6. CERN 50th Anniversary Official Celebration : one of the high momentsof the day: the signing of the golden book by the King of Spain Juan Carlos, the President of the Republic of France Jacques Chirac and the President of the Swiss Confederation Joseph Deiss

    CERN Multimedia

    Patrice Loiez

    2004-01-01

    CERN 50th Anniversary Official Celebration : one of the high momentsof the day: the signing of the golden book by the King of Spain Juan Carlos, the President of the Republic of France Jacques Chirac and the President of the Swiss Confederation Joseph Deiss

  7. CERN 50th Anniversary Official Celebration : one of the high moments of the day the signing of the golden book by the King of Spain Juan Carlos, the President of the Republic of France, Jacques Chirac and the President of the Swiss Confederation, Joseph Deiss

    CERN Multimedia

    Patrice Loeiz

    2004-01-01

    CERN 50th Anniversary Official Celebration : one of the high moments of the day the signing of the golden book by the King of Spain Juan Carlos, the President of the Republic of France, Jacques Chirac and the President of the Swiss Confederation, Joseph Deiss

  8. THE CONSTITUTIONAL ISSUE OF CROWNING IN CROATIANHUNGARIAN LAW (THE 150TH ANNIVERSARY OF THE EMPEROR FRANZ JOSEPH I CORONATION FOR THE KING OF HUNGARY AND CROATIA

    Directory of Open Access Journals (Sweden)

    László Heka

    2017-12-01

    Full Text Available This year marks the 150th anniversary of the Coronation of Franz Joseph l as the King of Hungary and Croatia which was marked by the Hungarian side as the condition of reconciliation with Vienna and the conclusion of the Austro-Hungarian settlement. This compromise between Austria and Hungary has served as a template for a yearlong Croatian-Hungarian settlement in many segments. With these two settlements, the Hungarians settled their relations with the court and with the Triune Kingdom of Croatia, Slavonia and Dalmatia, with whom Hungary had been in the state community since 1102. This event marked the end of a long-standing conflict with Austria, and the Croatian issue was removed from the agenda in Budapest and Vienna. In the course of eight centuries of the common statehood, the Coronation was one of the pivotal constitutional questions. The act of the Coronation, which gave the King legitimacy, consisted of the church ritual (anointing and the secular part manifested in taking the oath, and it had a public character and meaning. The latter was reflected in the fact that the crown oath and crown vow (the diplomas of inauguration were considered the contract between the people and the King, and therefore the Crown Defender had a constitutional character. The King got his legitimacy only if he was crowned with the crown of St. Stephen (the Holy Crown, so Franz Joseph l became the Hungarian and Croatian King only after the crowning in Buda. Since the palatine function was incomplete at the time, Hungary had to be represented by Count Gyula Andrassy, who was then the president of the government. After the King’s death in 1916, during the last royal Coronation, a political-legal debate was raised about whether Hungary should be represented by the Prime Minister or other person on behalf of the people.

  9. Leishmaniasis

    Science.gov (United States)

    ... cases of the disease have also appeared in Mexico and Texas. The disease takes several different forms, ... LaMontagne, Ph.D. James C. Hill, Ph.D. History Dr. Joseph J. Kinyoun: Father of the NIH ...

  10. Aerial radiological survey of the Joseph M. Farley Nuclear Plant and surrounding area, Dothan, Alabama

    International Nuclear Information System (INIS)

    Maguire, T.C.; Shipman, G.R.

    1982-03-01

    An aerial radiological survey was performed during the period 8 to 19 December 1979 over a 2000 square kilometer area centered on the two unit Joseph M. Farley Nuclear Plant near Dothan, Alabama. Radiological data were collected by flying north-south lines spaced 900 meters apart at an altitude of 150 meters above ground level. Processed data showed that all gamma rays detected within the survey area were those expected from naturally occurring radionuclides. Count rates obtained from the aerial platform were converted to exposure rates at 1 meter above the ground and are presented in the form of a radiation contour map. The observed exposure rates were between 4 and 12 microroentgens per hour (μR/h), with most of the area ranging between 4 and 10 μR/h. These values include an estimated cosmic ray contribution of 4.0 μR/h but do not include any contribution from airborne radionuclides, i.e., radon. Exposure rates obtained from ground measurements taken within the survey area were in close agreement with the aerial data. The data were also in close agreement with those obtained from a similar survey conducted during March 1977. Comparison of the results from both surveys indicated that no detectable change in the radiological characteristics of the survey area has occurred due to the operation of unit number 1 during the intervening period. The same equipment and procedures were utilized for both surveys

  11. Saint Joseph's University Institute for Environmental Stewardship

    Energy Technology Data Exchange (ETDEWEB)

    McCann, Micahel P. [Saint Joseph' s Univ., Philadelphia, PA (United States); Springer, Clint J. [Saint Joseph' s Univ., Philadelphia, PA (United States)

    2014-06-03

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in

  12. Extensive superior limbic keratoconjunctivitis in Graves’ disease: case report and mini-review of the literature

    Directory of Open Access Journals (Sweden)

    Chelala E

    2015-03-01

    Full Text Available Elias Chelala, Hala El Rami, Ali Dirani, Henry Fakhoury, Ali Fadlallah Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon Background: Superior limbic keratoconjunctivitis (SLK is characterized as an inflammation of the superior bulbar conjunctiva with predominant involvement of the superior limbus and adjacent epithelial keratitis.Methods: A 51-year-old woman, with a history of medically controlled Graves’ disease was seen with an extensive SLK involving 5 mm of the superior cornea.Results: Total remission was observed with topical steroids (DXM. Recurrence was observed 1 week after steroid discontinuation, and steroidal treatment was reintroduced with tapering over 1 month. Total remission was then observed for 1 year. Conclusion: Extensive keratitis and vascular pannus in SLK is rarely reported. This form could be treated with topical steroids. Tapering treatment remains essential for long-term success. Keywords: superior limbic keratoconjunctivitis, anti-inflammatory drugs, dexamethasone, triamcinolone, Graves’ disease

  13. Challenges for heart disease stem cell therapy

    Directory of Open Access Journals (Sweden)

    Hoover-Plow J

    2012-02-01

    Full Text Available Jane Hoover-Plow, Yanqing GongDepartments of Cardiovascular Medicine and Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USAAbstract: Cardiovascular diseases (CVDs are the leading cause of death worldwide. The use of stem cells to improve recovery of the injured heart after myocardial infarction (MI is an important emerging therapeutic strategy. However, recent reviews of clinical trials of stem cell therapy for MI and ischemic heart disease recovery report that less than half of the trials found only small improvements in cardiac function. In clinical trials, bone marrow, peripheral blood, or umbilical cord blood cells were used as the source of stem cells delivered by intracoronary infusion. Some trials administered only a stem cell mobilizing agent that recruits endogenous sources of stem cells. Important challenges to improve the effectiveness of stem cell therapy for CVD include: (1 improved identification, recruitment, and expansion of autologous stem cells; (2 identification of mobilizing and homing agents that increase recruitment; and (3 development of strategies to improve stem cell survival and engraftment of both endogenous and exogenous sources of stem cells. This review is an overview of stem cell therapy for CVD and discusses the challenges these three areas present for maximum optimization of the efficacy of stem cell therapy for heart disease, and new strategies in progress.Keywords: mobilization, expansion, homing, survival, engraftment

  14. La música de Franz Joseph Haydn en España: recopilación, catalogación e interpretación de las fuentes musicales conservadas en Madrid hasta 1833

    OpenAIRE

    Montero García, María del Rosario

    2013-01-01

    La música de Franz Joseph Haydn (1732-1809) fue adquirida e interpretada en España durante su vida. Prueba de esto es la existencia de un abundante número de impresos y copias manuscritas de obras musicales suyas dispersas por toda la geografía española, así como las frecuentes alusiones al compositor austriaco en fuentes españolas hemerográficas, teóricas, literarias y epistolares. Dichas fuentes muestran que la música de Haydn gozó de gran prestigio, incluso años después de su muerte, reper...

  15. e-EVN radio detection of Aql X-1 in outburst

    Science.gov (United States)

    Tudose, V.; Paragi, Z.; Yang, J.; Miller-Jones, J. C. A.; Fender, R.; Garrett, M.; Rushton, A.; Spencer, R.

    2013-06-01

    The neutron star X-ray binary Aql X-1 is currently in outburst (ATel #5114, #5117, #5129, #5136, #5148). Using the European VLBI Network (e-EVN) we observed Aql X-1 at 5 GHz in two time-slots: 2013 June 18 between 19:48 - 20:36 UT (MJD 56461.825 - 56461.858), and 2013 June 19 between 02:53 - 05:54 UT (MJD 56462.120 - 56462.246). The two datasets were combined together and then calibrated. The participating radio telescopes were: Effelsberg (Germany), Jodrell Bank Mk2 (UK), Medicina (Italy), Noto (Italy), Onsala 25m (Sweden), Torun (Poland), Yebes (Spain), Westerbork Synthesis Radio Telescope (Netherlands), Shanghai (China), Hartebeesthoek (South Africa).

  16. Greek versions of the Life of Saint Onnophrius the Great and an archive by Father Joseph Paramelle (s.j, 1925–2011

    Directory of Open Access Journals (Sweden)

    Voitenko Anton

    2015-08-01

    Full Text Available The article focuses on the studies of the Greek manuscript tradition of the Life of Saint Onnophrius the Great, which is still almost unexplored. In this paper, based on analysis of the published versions of the Life, as well as copies of unpublished Greek manuscripts made by Father Joseph Paramelle, the existence of fi ve diff erent Greek versions of the Life (types I–V is established. Among all the installed versions, the only one (type I contains a text the closest to the original version of the Life. It is attested by three Greek manuscripts. All other types are later redactions of the original text. Types II–IV present the abridged versions of the Life, the type V is a partially shortened and strongly metaphrastic text descended probably from the Mount Athos. On the basis of circumstantial evidence, it was assumed the existence of at least another three versions of the Life

  17. 'Eating, eating is always there': food, consumerism and cardiovascular disease. Some evidence from Kerala, south India.

    Science.gov (United States)

    Wilson, Caroline

    2010-12-01

    The state of Kerala, south India, has particularly high prevalence rates for cardiovascular disease (20%, Sugathan, Soman and Sankaranarayanan 2008) and Type II diabetes (16.3%, Kutty, Joseph, and Soman 1999). Although so-called 'lifestyle' diseases can be prevented and symptoms controlled by diet, exercise, and medicines, heart disease and diabetes have become the most common causes of suffering, disability and death. This article explores the social dynamics transforming consumer lifestyles as increased food consumption, reduced physical activity and social stress contribute to the burden of cardiovascular disease (CVD). It examines the centrality of food to ideas of the 'good life', to nurture social relationships and strengthen weak modern bodies, as the principle source of embodied pleasure and health. It explores the micro and macro politics of eating and feasting, limiting the extent to which 'individuals' (can) control food habits. Thus, despite widespread recognition of the relationship between diet, exercise and heart disease, the flow of food, the immediacy of pleasure, and associations between appetite and health override latent concerns about the negative impacts of dietary excesses on long-term health and chronic illness. Findings are discussed to highlight the inherent limitations of public health interventions focusing on education and individual choice.

  18. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispell Department of Natural Resources, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife, Spokane, WA); O' Connor, Dick (Washington Department of Fish and Wildlife, Olympia, WA)

    2003-01-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power Planning Council (NPPC). The NPPC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPPC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area and the Columbia Basin Blocked Area Management Plan

  19. Resident Fish Stock above Chief Joseph and Grand Coulee Dams; 2003-2004 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispel Tribe of Indians, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife, Olympia, WA); Butler, Chris (Spokane Tribe of Indians, Wellpinit, WA)

    2005-11-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial and native fish assemblages in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The

  20. EMERGING INFECTIOUS DISEASES. Actions Needed to Address the Challenges of Responding to Zika Virus Disease Outbreaks

    Science.gov (United States)

    2017-05-01

    Epidemiology, and Mosquito Control 17 Table 2: Zika Virus Cases and Birth Defects Associated with the Zika Virus Reported in the Americas, 2015–2017...meetings and conferences, holding public events at schools , buying radio time, and communicating online. Mosquito control entity officials told us that...Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School Joseph M. Conlon, M.Sc., BCE, Technical Adviser, American Mosquito Control

  1. [The vitalism of Paul-Joseph Barthez (1734-1806)].

    Science.gov (United States)

    Han, Hee Jin

    2010-06-30

    In The Logic of Life (1970), Francois Jacob (1920- ), Nobel Prize laureate in Physiology or Medicine (1965), proclaimed the end of vitalism based on the concept of life. More than two decades before this capital sentence condemning vitalism was pronounced, Georges Canguilhem (1904-1995), a French philosopher of medicine, already acknowledged that eighteenth-century vitalism was scientifically retrograde and politically reactionary or counter-revolutionary insofar as it was rooted in the animism of Georg Ernst Stahl (1660-1734). The negative preconception of the term 'vitalism' came to be established as an orthodox view, since Claude Bernard (1813-1878) unfairly criticized contemporary vitalism in order to propagate his idea of experimental medicine. An eminent evolutionary biologist like Ernst Mayr (1904-2005) still defended similar views in This is Biology (1997), arguing that if vitalists were decisive and convincing in their rejection of the Cartesian model (negative heuristics), however they were equally indecisive and unconvincing in their own explanatory endeavors (positive heuristics). Historically speaking, vitalists came to the forefront for their outstanding criticism of Cartesian mechanism and physicochemical reductionism, while their innovative concepts and theories were underestimated and received much less attention. Is it true that vitalism was merely a pseudo-science, representing a kind of romanticism or mysticism in biomedical science? Did vitalists lack any positive heuristics in their biomedical research? Above all, what was actually the so.called 'vitalism'? This paper aims to reveal the positive heuristics of vitalism defined by Paul.Joseph Barthez (1734-1806) who was the founder of the vitalist school of Montpellier. To this end, his work and idea are introduced with regard to the vying doctrines in physiology and medicine. At the moment when he taught at the medical school of Montpellier, his colleagues advocated the mechanism of Rene

  2. Um Professor de Paleontologia: Ignácio Brito (1938-2001)

    OpenAIRE

    Diógenes de Almeida Campos

    2001-01-01

    11 Anuário do Instituto de Geociências - UFRJ Volume 24 / 2001 Um Professor de Paleontologia: Ignacio Brito (1938-2001) Diogenes de Almeida Campos Museu de Ciências da Terra - DNPM Ignacio Aureliano Machado Brito, nascido no Rio de Janeiro, em 29 de junho de 1938, filho de Gratuliano da Costa Brito e de Adelaide Machado Brito, realizou seus estudos de nível médio no Colégio Mallet Soares, tendo concluído os mesmos em 1956. Suas atividades profissionais foram desenvolvidas primeirament...

  3. Iron deficiency anemia in patients with inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Goldberg ND

    2013-06-01

    Full Text Available Neil D Goldberg Emeritus Chief of Gastroenterology, University of Maryland St. Joseph Medical Center, Towson, MD, USA Abstract: Iron deficiency anemia is the most common form of anemia worldwide, caused by poor iron intake, chronic blood loss, or impaired absorption. Patients with inflammatory bowel disease (IBD are increasingly likely to have iron deficiency anemia, with an estimated prevalence of 36%–76%. Detection of iron deficiency is problematic as outward signs and symptoms are not always present. Iron deficiency can have a significant impact on a patient's quality of life, necessitating prompt management and treatment. Effective treatment includes identifying and treating the underlying cause and initiating iron replacement therapy with either oral or intravenous iron. Numerous formulations for oral iron are available, with ferrous fumarate, sulfate, and gluconate being the most commonly prescribed. Available intravenous formulations include iron dextran, iron sucrose, ferric gluconate, and ferumoxytol. Low-molecular weight iron dextran and iron sucrose have been shown to be safe, efficacious, and effective in a host of gastrointestinal disorders. Ferumoxytol is the newest US Food and Drug Administration-approved intravenous iron therapy, indicated for iron deficiency anemia in adults with chronic kidney disease. Ferumoxytol is also being investigated in Phase 3 studies for the treatment of iron deficiency anemia in patients without chronic kidney disease, including subgroups with IBD. A review of the efficacy and safety of iron replacement in IBD, therapeutic considerations, and recommendations for the practicing gastroenterologist are presented. Keywords: anemia, inflammatory bowel disease, intravenous iron, iron deficiency, oral iron, therapy

  4. Did ASAS-SN Kill the Supermassive Black Hole Binary Candidate PG1302-102?

    Science.gov (United States)

    Liu, Tingting; Gezari, Suvi; Miller, M. Coleman

    2018-05-01

    Graham et al. reported a periodically varying quasar and supermassive black hole binary candidate, PG1302-102 (hereafter PG1302), which was discovered in the Catalina Real-time Transient Survey (CRTS). Its combined Lincoln Near-Earth Asteroid Research (LINEAR) and CRTS optical light curve is well fitted to a sinusoid of an observed period of ≈1884 days and well modeled by the relativistic Doppler boosting of the secondary mini-disk. However, the LINEAR+CRTS light curve from MJD ≈52,700 to MJD ≈56,400 covers only ∼2 cycles of periodic variation, which is a short baseline that can be highly susceptible to normal, stochastic quasar variability. In this Letter, we present a reanalysis of PG1302 using the latest light curve from the All-sky Automated Survey for Supernovae (ASAS-SN), which extends the observational baseline to the present day (MJD ≈58,200), and adopting a maximum likelihood method that searches for a periodic component in addition to stochastic quasar variability. When the ASAS-SN data are combined with the previous LINEAR+CRTS data, the evidence for periodicity decreases. For genuine periodicity one would expect that additional data would strengthen the evidence, so the decrease in significance may be an indication that the binary model is disfavored.

  5. Joseph Black, carbon dioxide, latent heat, and the beginnings of the discovery of the respiratory gases.

    Science.gov (United States)

    West, John B

    2014-06-15

    The discovery of carbon dioxide by Joseph Black (1728-1799) marked a new era of research on the respiratory gases. His initial interest was in alkalis such as limewater that were thought to be useful in the treatment of renal stone. When he studied magnesium carbonate, he found that when this was heated or exposed to acid, a gas was evolved that he called "fixed air" because it had been combined with a solid material. He showed that the new gas extinguished a flame, that it could not support life, and that it was present in gas exhaled from the lung. Within a few years of his discovery, hydrogen, nitrogen, and oxygen were also isolated. Thus arguably Black's work started the avalanche of research on the respiratory gases carried out by Priestley, Scheele, Lavoisier, and Cavendish. Black then turned his attention to heat and he was the first person to describe latent heat, that is the heat added or lost when a liquid changes its state, for example when water changes to ice or steam. Latent heat is a key concept in thermal physiology because of the heat lost when sweat evaporates. Black was a friend of the young James Watt (1736-1819) who was responsible for the development of early steam engines. Watt was puzzled why so much cooling was necessary to condense steam into water, and Black realized that the answer was the latent heat. The resulting improvements in steam engines ushered in the Industrial Revolution. Copyright © 2014 the American Physiological Society.

  6. DR AVRAM JOZEF VINAVER (1862-1915) - PIONEER OF RADIOLOGY IN SERBIA.

    Science.gov (United States)

    Babić, Rade Radomir; Stanković Babić, Gordana

    2015-01-01

    Dr Abraham Joseph Vinaver (1862-1915), a Jew from Poland, was a pioneer of radiology in Serbia. He graduated from the Faculty of Medicine in Warsaw (1887), but lived and worked in abac (the Kingdom of Serbia) since 1890. Dr Abraham Joseph Vinarev - Career Development. He procured the first X-ray machine and developed radiological service in Sabac five years after the discovery of X-rays. These were the beginnings of radiology in Serbia. He introduced the application of artesian wells. Dr Abraham Joseph Vinarev - a Participant at the First Congress of Serbian Physicians and Naturalists, Belgrade 1904. "The diagnostic importance of X-rays in lung disease, especially in initial tuberculosis" and "Five Years of Treatment by X-Ray Machines" were the first works in the field of radiology in Serbia by this author. Dr Abraham Joseph Vinaver - Reserve Medical Officer in the Serbian Army. During the Balkan Wars, he was a volunteer with the rank of major engaged in military corps and he participated in the First World War as well. He died of malaria in 1915 in Gevgelija. "Dr Avram Vinaver"- Stanislav Vinarev. His dedication to work during the typhus epidemics was put into verses of a poem by his son Stanislav Vinarev. Dr Avram Vinaver Joseph was a noble man with a great heart, who selflessly sacrificed himself for the Serbian people and Serbia. He gave his contribution to the development of health services in Serbia, both in peacetime and wartime conditions. Dr Abraham Joseph Vinaver laid the foundations for today's radiology in Serbia.

  7. Fédéralisme, identités nationales et critique des frontières naturelles : Pierre-Joseph Proudhon (1809-1865) géographe des « États-Unis d'Europe »

    OpenAIRE

    Ferretti , Federico; Castleton , Edward

    2016-01-01

    Cet article aborde la question de la « géographicité » de l’œuvre du philosophe et militant Pierre-Joseph Proudhon, dans le cadre des études sur les relations entre géographie et anarchisme, théorie politique dont Proudhon est considéré comme l’un des fondateurs. À partir de ses textes édits et inédits, nous interrogeons le rapport de Proudhon à la géographie, notamment dans la construction de ses approches du fédéralisme et du problème des nationalités. Au sein de l’immense corpus proudhonie...

  8. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2002-2003 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispel Tribe of Indians, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife); Butler, Chris (Spokane Tribe of Indians, Wellpinit, WA)

    2006-02-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial and native fish assemblages in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The

  9. Integrating Strategic and Operational Decision Making Using Data-Driven Dashboards: The Case of St. Joseph Mercy Oakland Hospital.

    Science.gov (United States)

    Jack Weiner; Balijepally, Venugopal; Tanniru, Mohan

    2015-01-01

    Hospitals have invested and continue to invest heavily in building information systems to support operations at various levels of administration. These systems generate a lot of data but fail to effectively convert these data into actionable information for decision makers. Such ineffectiveness often is attributed to a lack of alignment between strategic planning and information technology (IT) initiatives supporting operational goals. We present a case study that illustrates how the use of digital dashboards at St. Joseph Mercy Oakland (SJMO) Hospital in Pontiac, Michigan, was instrumental in supporting such an alignment. Driven by a focus on key performance indicators (KPIs), dashboard applications also led to other tangible and intangible benefits. An ability to track KPIs over time and against established targets, with drill-down capabilities, allowed leadership to hold staff members accountable for achieving their performance targets. By displaying the dashboards in prominent locations (such as operational unit floors, the physicians' cafeteria, and nursing stations), SJMO ushered in transparency in the planning and monitoring processes. The need to develop KPI metrics and drive data collection efforts became ingrained in the work ethos of people at every level of the organization. Although IT-enabled dashboards have been instrumental in supporting this cultural transformation, the focus of investment was the ability of technology to make collective vision and action the responsibility of all stakeholders.

  10. Adherence to systemic therapies for immune-mediated inflammatory diseases in Lebanon: a physicians’ survey from three medical specialties

    Directory of Open Access Journals (Sweden)

    Ammoury A

    2017-05-01

    Full Text Available Alfred Ammoury,1 Jad Okais,2 Mireille Hobeika,3 Raymond B Sayegh,4 Rani H Shayto,5 Ala I Sharara5 1Division of Dermatology, St George Hospital University Medical Center, 2Division of Rheumatology, St Joseph University, 3AbbVie Levant, 4Division of Gastroenterology, St Joseph University, 5Department of Internal Medicine, Division of Gastroenterology, American University of Beirut Medical Center, Beirut, Lebanon Background: Immune-mediated inflammatory diseases (IMIDs are chronic conditions that may cause tissue damage and disability, reduced quality of life and increased mortality. Various treatments have been developed for IMIDs, including immune modulators and targeted biologic agents. However, adherence remains suboptimal. Methods: An adherence survey was used to evaluate physicians’ beliefs about adherence to medication in IMID and to evaluate if and how they manage adherence. The survey was distributed to 100 randomly selected physicians from three different specialties. Results were analyzed by four academic experts commissioned to develop an action plan to address practical and perceptual barriers to adherence, integrating it into treatment goals to maximize outcomes in IMID, thereby elevating local standards of care. Results: Eighty-two physicians participated in this study and completed the questionnaire. Most defined adherence as compliance with prescribed treatment. Although the majority of surveyed physicians (74% did not systematically measure adherence in their practice, 54% identified adherence as a treatment goal of equal or greater importance to therapeutic endpoints. Lack of time and specialized nursing support was reported as an important barrier to measuring adherence. The expert panel identified four key areas for action: 360° education (patient–nurse–physician, patient–physician communication, patient perception and concerns, and market access/cost. An action plan was developed centered on education and awareness

  11. Proton pump inhibitors for the treatment of patients with erosive esophagitis and gastroesophageal reflux disease: current evidence and safety of dexlansoprazole

    Directory of Open Access Journals (Sweden)

    Mermelstein J

    2016-07-01

    Full Text Available Joseph Mermelstein,1 Alanna Chait Mermelstein,2 Maxwell M Chait,3 1Department of Medicine, Mount Sinai Beth Israel/Icahn School of Medicine, 2Department of Psychiatry, New York Presbyterian Hospital/Weill Cornell Medicine, 3Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA Abstract: Gastroesophageal reflux disease is the most common upper gastroenterology disorder in the US. It is associated with a variety of complications and significantly impacts quality of life. Proton pump inhibitors are the most effective treatment. Dexlansoprazole modified release (MR is a proton pump inhibitor that employs a novel release formulation that prolongs its absorption and allows for more flexibility in dosing. Dexlansoprazole MR can be dosed without regard to food intake or time of day, and once-daily dosing may replace twice-daily dosing of other agents. Dexlansoprazole MR is effective for healing and maintenance of erosive esophagitis, and for the treatment of nonerosive disease, including nocturnal gastroesophageal reflux disease. Dexlansoprazole MR is safe and well tolerated, and can improve quality of life. Keywords: dexlansoprazole, proton pump inhibitors, gastroesophageal reflux disease, erosive esophagitis

  12. Risk assessment for the reintroduction of anadromous salmonids upstream of Chief Joseph and Grand Coulee Dams, Northeastern Washington

    Science.gov (United States)

    Hardiman, Jill M.; Breyta, Rachel B.; Haskell, Craig A.; Ostberg, Carl O.; Hatten, James R.; Connolly, Patrick J.

    2017-09-12

    The Upper Columbia United Tribes (UCUT; Spokane, Colville, Kootenai, Coeur d’Alene, and Kalispel Tribes) and Washington Department of Fish and Wildlife want to reintroduce anadromous salmonids to their historical range to restore ecosystem function and lost cultural and spiritual relationships in the upper Columbia River, northeastern Washington. The UCUT contracted with the U.S. Geological Survey to assess risks to resident taxa (existing fish populations in the reintroduction area upstream of Chief Joseph and Grand Coulee Dams) and reintroduced salmon associated with reintroduction. We developed a risk assessment framework for reintroduction of anadromous salmonids upstream of Chief Joseph and Grand Coulee Dams. To accomplish this goal, we applied strategies identified in previous risk assessment frameworks for reintroduction. The risk assessment is an initial step towards an anadromous reintroduction strategy. An initial list of potential donor sources for reintroduction species was developed from previous published sources for Chinook Salmon (Oncorhynchus tshawytscha) donors in the Transboundary Reach of the Columbia River, British Columbia; an ecological risk assessment of upper Columbia River hatchery programs on non-target taxa of concern; and a review of existing hatchery programsDuring two workshops, we further identified and ranked potential donor sources of anadromous Redband Trout (steelhead; O. mykiss), Chinook Salmon, Sockeye Salmon (O. nerka), and Coho Salmon (O. kisutch). We also identified resident fish populations of interest and their primary habitat, location, status, and pathogen concerns to determine the potential risks of reintroduction. Species were deemed of interest based on resource management and potential interactions (that is, genetics, competition, and predation) with introduced species. We developed tables of potential donors by species and characterized potential sources (hatchery and natural origins), populations (individual runs

  13. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2003-2004 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, M.; McKinstry, C.; Cook, C.

    2004-01-01

    Since 1995, the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes) have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation from 1996 to 1999 determined that from 211,685 to 576,676 fish were entrained annually at Grand Coulee Dam. Analysis of the entrainment data found that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the third year of the strobe light study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory. The objective of the study is to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout under field conditions. The prototype system consists of six strobe lights affixed to an aluminum frame suspended 15 m vertically underwater from a barge secured in the center of the entrance to the third powerplant forebay. The lights, controlled by a computer, illuminate a region directly upstream of the barge. The 2003 study period extended from June 16 through August 1. Three light treatments were used: all six lights on for 24 hours, all lights off for 24 hours, and three of six lights cycled on and off every hour for 24 hours. These three treatment conditions were assigned randomly

  14. Green sea turtle age, growth, population characteristics

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Morphology, sex ratio, body condition, disease status, age structure, and growth patterns were characterized for 448 green sea turtles cold stunned in St. Joseph...

  15. Medical doctors as the captain of a ship: an analysis of medical students' book reports on Joseph Conrad's "Lord Jim".

    Science.gov (United States)

    Hwang, Kun; Lee, Seung Jae; Kim, Seong Yeon; Hwang, Se Won; Kim, Ae Yang

    2014-01-01

    In South Korean ferry disaster in 2014, the captain abandoned the ship with passengers including high school students still aboard. We noticed the resemblance of abandoning the ship with passengers still aboard the ferry (named the Sewol) and the ship Patna, which was full of pilgrims, in Joseph Conrad's novel "Lord Jim." The aim of this study is to see how medical students think about the role of a medical doctor as a captain of a ship by analyzing book reports on Conrad's "Lord Jim." Participants included 49 third-year medical students. Their book reports were analyzed. If placed in the same situation as the character of Jim, 24 students of the 49 respondents answered that they would stay with the passengers, while 18 students indicated they would escape from the ship with the crew. Most of the students thought the role of a doctor in the medical field was like that of a 'captain.' The medical students reported that they wanted to be a doctor who is responsible for his or her patients, highly moral, warm-hearted, honest, and with high self-esteem. In conclusion, we found that "Lord Jim" induced the virtue of 'responsibility' from the medical students. Consequently, "Lord Jim" could be good teaching material for medical humanities.

  16. Helena: representações de práticas de leitura e configurações do leitorado oitocentista brasileiro no romance machadiano

    Directory of Open Access Journals (Sweden)

    Patrí­cia Kátia da Costa Pina

    2011-10-01

    Full Text Available Resumo: Este artigo estuda as representações de atos de leitura presentes no romance Helena, de Machado de Assis, interpretando-as como instrumentos capazes de configurar o leitorado brasileiro oitocentista. Para tanto, são analisadas comparativamente as cenas de leitura protagonizadas por D. Úrsula, Helena e Estácio, tendo em vista as relações sociais, políticas e históricas que cercam a trama e as personagens recortadas. São observados modos de ler “masculinos” e “femininos”, que viabilizam a reflexão sobre o lugar da mulher nesse Brasil ainda patriarcal e já caminhando para o capitalismo. O objetivo é investigar de que maneira esse romance machadiano funciona para formar e manter padrões de gosto pela leitura literária. A argumentação se sustenta, fundamentando-se nas ideias de Wolfgang Iser, Roger Chartier, Marisa Lajolo, Regina Zilberman, Hélio Guimarães, entre outros.Palavras-chave: Machado de Assis; Helena; leitura; gênero.Resumen: Este artículo estudia las representaciones de actos de lectura presentes en la novela Helena, de Machado de Assis, interpretándolas como instrumentos capaces de configurar el lector brasileño decimonónico. Para eso, se analizan de forma comparativa las escenas de lectura protagonizadas por Doña Úrsula, Helena y Estácio, considerando las relaciones sociales, políticas e históricas que involucran la trama y los personajes en cuestión. Se observan modos de leer “masculinos” y “femeninos”, que hacen viable la reflexión sobre el lugar de la mujer en ese Brasil aún patriarcal y caminando ya hacia el capitalismo. El objetivo es investigar de qué manera esa novela machadiana funciona para formar y mantener patrones de gusto por la lectura literaria. La argumentación se sostiene, fundamentándose en las ideas de Wolfgang Iser, Roger Chartier, Marisa Lajolo, Regina Zilberman, Hélio Guimarães, entre otros.Palabras-clave: Machado de Assis; Helena; lectura; g

  17. La revista Demófilo y la antropología cultural en Andalucía

    Directory of Open Access Journals (Sweden)

    Rodríguez Becerra, Salvador

    2002-06-01

    Full Text Available Published since 1987 by the Machado Foundation, of Seville, Demófilo represents the resumption of scientific folklore studies in the late 19th century championed by Antonio Machado y Álvarez and published in the journal El Folk-lore Andaluz. The basic objectives of Demófilo are «to rescue, analyze and divulge Andalousia's traditional culture.» The journal is oriented toward high schools, colleges and universities in Andalousia as well as any institution interested in the traditional culture of the area, such as museums and organizations supporting Andalousia's cultural heritage. The authors also include in this article a summary of the journal's monographic issues published to date.

    Publicación de la Fundación Machado, de Sevilla, y nacida en 1987, Demófilo enlaza con su predecesora en el siglo XIX, El Folk-lore Andaluz, del movimiento sevillano de estudio científico del folklore que animara sobre todo Antonio Machado y Álvarez. Demófilo tiene como objetivos básicos «rescatar, analizar y difundir la cultura tradicional andaluza» y va dirigida especialmente a centros de enseñanza media y universidades de Andalucía, así como a instituciones interesadas en la cultura tradicional de la región, como museos y asociaciones de defensa del patrimonio cultural. Los autores incluyen también en este artículo un resumen de los números monográficos de la revista publicados hasta la fecha.

  18. Total Energy Expenditure (TEE) measured with the doubly labeled water technique in women from 60 to 70 years of age from Havana City, Cuba

    International Nuclear Information System (INIS)

    Hernandez-Triana, M.H.; Porrata, C.; Estrada, G.; Diaz, M.E.; Martin, I.; Bayley, H.; McCormack, B.A.; Jones, P.J.H.

    2002-01-01

    Aim: With the purpose to measure the Total Energy Expenditure (TEE) and to validate the Cuban Dietary Energy Allowance for elderly subjects, energy expenditure was assessed by the doubly labeled water technique in 11 women aged 65.9 ± 2.8 y with a mean BMI of 21.4 ± 4.2 kg/m2 during 14 days under free-living conditions in their own environment in Havana City. Materials and Methods: After taking a basal urine sample, the women received an oral dose of 2.5 g H218O (10%) and 0.12 g 2H2O (99.8%) body weight and samples of saliva and urine were collected 14 days after. Resting Metabolic Rate (RMR) was estimated by the Schofield equations proposed by the 1985 FAO/WHO/UNU Expert Committee Report and energy intake was measured by trained dietitians using the 3-day weighed dietary record. A mean value of the food quotient of 0.85 was used for the calculations of the CO2 production by the isotopic method. Results: In spite of the expected variability, the differences between TEE measured by the isotopic method (7.57 MJ/d) and estimated according to FAO/WHO/UNU, 1985 (7.24 MJ/d) were not significant (0.625). The recommended dietary allowance for energy valid for Cuban elderly subjects (7.66 MJ/d) was only slight over the value of the measured TEE. The value of energy expenditure measured in free-living elderly women from Havana City was in the range of acceptable values (6-8 MJ/d) for this group of age. Conclusions: The total energy expenditure of elderly women from Havana City was lower than reported values for women living in developed countries but coincident with those of women of the developing world. The differences between dietary energy intake and TEE measured by the isotopic method were around 27% and coincident with previous reports in elderly people. The Cuban allowance for dietary energy for elderly women was enough for covering their energy requirements

  19. Disease management of early childhood caries: results of a pilot quality improvement project.

    Science.gov (United States)

    Ng, Man Wai; Torresyap, Gay; White, Alex; Melvin, Patrice; Graham, Dionne; Kane, Daniel; Scoville, Richard; Ohiomoba, Henry

    2012-08-01

    The purpose is to report findings of a quality improvement (QI) project implemented at two hospital-based dental clinics that care for children with early childhood caries (ECC). We tested a disease management (DM) approach in children younger than age 60 months with ECC. After 30 months, for the 403 and 234 DM patients at Children's Hospital Boston (CHB) and Saint Joseph Hospital (SJH) who returned for at least two visits, rates of new cavitation, pain, and referrals to the OR were 26.1, 13.4 and 10.9% for CHB and 41.0, 7.3 and 14.9% for SJH. Rates of new cavitation, pain, and referrals to the OR for historical controls were 75.2, 21.7, and 20.9% for CHB and 71.3, 31.3, and 25.0% for SJH. A risk-based DM approach utilizing QI strategies to address ECC can be implemented into practice and has the potential to improve care and health outcomes.

  20. Genotyping and prenatal diagnosis of a large spinocerebellar ataxia ...

    Indian Academy of Sciences (India)

    2011-08-19

    Aug 19, 2011 ... range of eye movements with horizontal nystagmus, dysdi- adochokinesia, and ... individuals; open symbols indicate normal individuals; grey sym- bols indicate .... prenatal diagnosis of a fetus at risk of MJD. In conclusion, we ...

  1. A relação narrador/leitor na tradução machadiana de Oliver Twist

    Directory of Open Access Journals (Sweden)

    Franciano Camelo

    Full Text Available Em 1870, a convite dos proprietários do Jornal da Tarde, Machado de Assis traduziu para o português boa parte do romance Oliver Twist, de Charles Dickens. A tradução machadiana desse romance apresenta particularidades, isto é, as estruturas que põem a assimilação do texto em curso na tradução de Machado de Assis diferem daquelas do texto inglês. Dentre essas estruturas, destaca-se a voz narrativa. Assim, este trabalho visa analisar alguns aspectos da voz narrativa na tradução machadiana e discutir possíveis implicações para o âmbito do leitor implícito.

  2. Dom Casmurro

    Directory of Open Access Journals (Sweden)

    Agripino Grieco

    2011-12-01

    Full Text Available "Sou dos que encontram uma espécie de magnetismo suspeito em Joaquim Maria. Admiro-o resmungando contra a minha admiração. E até parece que o que mais aproxima tanta gente dele é mesmo o fato de discordar tanto dele, de se irritar tanto em dados trechos. No amor a inteligências dessas há qualquer coisa de indefinível como no vício do jogo." Foi sempre nesse tom, meio a contragosto, com raiva da sua admiração incontrolável, que Agripino Grieco escreveu sobre Machado de Assis. O autor de Dom Casmurro foi uma espécie de cachaça para esse poeta, jornalista e crítico controverso, fluminense nascido em Paraíba do Sul em 1888, às vezes tão mal humorado que se tornava divertido na sua ranzinzice. Um exemplo dessa combinação peculiar de mau humor e graça: "se pudéssemos obter a média das personagens de Machado, diríamos que sua principal criação namora viúva, lê romance francês, vai passear na Tijuca, é sovina e queima rato." Seguindo a linhagem de Sílvio Romero, que viu e recriminou em Machado o macaqueador do humorismo de Sterne, Grieco deu mais um giro no estilete romeriano, apelidando Machado de "Sterne do Cais Pharoux". Amante da frase ferina, que nem sempre vem acompanhada do julgamento justo, foi capaz de sentenciar, em pleno 1959, quando o futebol já se tornara esporte nacional e promovera grandes comoções (como a perda da Copa do Mundo para o Uruguai no Maracanã, em 1950, que "duas coisas, especificamente da zona de John Bull, não convêm absolutamente aos trópicos: o futebol e o humour." A passagem do tempo se encarregou de contradizer o crítico. Mas naqueles anos, marcados por uma verdadeira machadolatria, alimentada pelas comemorações do centenário do nascimento, em 1939, e pelas homenagens ao cinquentenário da morte, celebrados em 1958, Agripino Grieco provocou a ira de muita gente. Assim, não é de espantar o estrondo que produziram os dois livros que dedicou integralmente ao criador de Capitu

  3. Neurofibromatosis type 1 and the "elephant man's" disease: the confusion persists: an ethnographic study.

    Science.gov (United States)

    Legendre, Claire-Marie; Charpentier-Côté, Catherine; Drouin, Régen; Bouffard, Chantal

    2011-02-09

    In 1986, two Canadian geneticists had demonstrated that Joseph Merrick, better known as the Elephant Man, suffered from the Proteus syndrome and not from neurofibromatosis type 1 (NF1), as was alleged by dermatologist Parkes in 1909. Despite this and although the two diseases differ at several levels: prevalence, diagnostic criteria, clinical manifestations and transmission, the confusion between NF1 and the "elephant man's" disease continues in medical and social representations by current linguistic usage, and in some media reports. With this article, we want to 1) document the persistence and extent of this fallacy, 2) identify certain critical factors that contribute to its persistence, and 3) evaluate its impact on the health and well being of patients with NF1 and their family members. Participant observation in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents - Analysis of the scientific literature and of pinpoint articles in the print and online news media. Our findings show that because physicians have little knowledge about NF1, several print and online news media and a lot of physicians continue to make the confusion between NF1 and the disease the "elephant man". This misconception contributes to misinformation about the disease, feeding prejudices against affected patients, exacerbating the negative impacts of the disease on their quality of life, their cognitive development, their reproductive choices, as well as depriving them of proper care and appropriate genetic counseling. If family physicians and pediatricians were properly informed about the disease, they could refer their patients with NF1 to NF clinics and to specialists. Thus, patients and their family members would benefit from better-tailored clinical management of their cases, perhaps even optimal management. [corrected

  4. Neurofibromatosis type 1 and the "elephant man's" disease: the confusion persists: an ethnographic study.

    Directory of Open Access Journals (Sweden)

    Claire-Marie Legendre

    2011-02-01

    Full Text Available In 1986, two Canadian geneticists had demonstrated that Joseph Merrick, better known as the Elephant Man, suffered from the Proteus syndrome and not from neurofibromatosis type 1 (NF1, as was alleged by dermatologist Parkes in 1909. Despite this and although the two diseases differ at several levels: prevalence, diagnostic criteria, clinical manifestations and transmission, the confusion between NF1 and the "elephant man's" disease continues in medical and social representations by current linguistic usage, and in some media reports. With this article, we want to 1 document the persistence and extent of this fallacy, 2 identify certain critical factors that contribute to its persistence, and 3 evaluate its impact on the health and well being of patients with NF1 and their family members.Participant observation in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents - Analysis of the scientific literature and of pinpoint articles in the print and online news media.Our findings show that because physicians have little knowledge about NF1, several print and online news media and a lot of physicians continue to make the confusion between NF1 and the disease the "elephant man". This misconception contributes to misinformation about the disease, feeding prejudices against affected patients, exacerbating the negative impacts of the disease on their quality of life, their cognitive development, their reproductive choices, as well as depriving them of proper care and appropriate genetic counseling.If family physicians and pediatricians were properly informed about the disease, they could refer their patients with NF1 to NF clinics and to specialists. Thus, patients and their family members would benefit from better-tailored clinical management of their cases, perhaps even optimal management. [corrected

  5. 76 FR 52958 - Draft Guidance for Industry on Neglected Tropical Diseases of the Developing World: Developing...

    Science.gov (United States)

    2011-08-24

    ...: The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry... guidance to the Division of Drug Information, Center for Drug Evaluation and Research, Food and Drug... FURTHER INFORMATION CONTACT: Joseph G. Toerner, Center for Drug Evaluation and Research, Food and Drug...

  6. 77 FR 39965 - Endangered and Threatened Wildlife and Plants; Listing the Hyacinth Macaw

    Science.gov (United States)

    2012-07-06

    .... 229). A network of nongovernmental organizations, Rede Cerrado, has been established to promote local sustainable-use practices for natural resources (Klink and Machado 2005, p. 710). Rede Cerrado provided the...

  7. Early Bacterial Cultures from Open Fractures - Differences Before ...

    African Journals Online (AJOL)

    multiruka1

    the gastrointestinal or genitourinary injuries or were known to have diabetes, peripheral vascular disease or immunosuppression. Informed consent was obtained. Early Bacterial Cultures from Open Fractures -. Differences Before and After Debridement. Fred Chuma Sitati1, Philip Ogutu Mosi2, Joseph Cege Mwangi1. 1.

  8. Imagens do judeu em quatro romances da geração de 1930

    Directory of Open Access Journals (Sweden)

    Márcio Henrique Muraca

    2014-05-01

    Full Text Available O judeu em Suor (1934, de Jorge Amado, Caminho de pedras (1937, de Rachel de Queiroz, Angústia (1936, de Graciliano Ramos, e Os ratos (1935, de Dyonélio Machado, aparece de modo rápido, sobretudo nos dois últimos. Ainda assim, tal representação aponta para conceitos que circundam aquele povo no imaginário brasileiro. Em Amado e Queiroz, o judeu é representado como agitador comunista estrangeiro. Em Ramos e Machado, como negociante capitalista. Porém, conforme a complexidade de cada obra, esse judeu apresenta também matizes em sua representação que vão além da mera redução do estereótipo.

  9. Medical doctors as the captain of a ship: an analysis of medical students’ book reports on Joseph Conrad’s “Lord Jim”

    Science.gov (United States)

    2014-01-01

    Purpose: In South Korean ferry disaster in 2014, the captain abandoned the ship with passengers including high school students still aboard. We noticed the resemblance of abandoning the ship with passengers still aboard the ferry (named the Sewol) and the ship Patna, which was full of pilgrims, in Joseph Conrad’s novel “Lord Jim.” The aim of this study is to see how medical students think about the role of a medical doctor as a captain of a ship by analyzing book reports on Conrad’s “Lord Jim.” Methods: Participants included 49 third-year medical students. Their book reports were analyzed. Results: If placed in the same situation as the character of Jim, 24 students of the 49 respondents answered that they would stay with the passengers, while 18 students indicated they would escape from the ship with the crew. Most of the students thought the role of a doctor in the medical field was like that of a ‘captain.’ The medical students reported that they wanted to be a doctor who is responsible for his or her patients, highly moral, warm-hearted, honest, and with high self-esteem. Conclusion: In conclusion, we found that “Lord Jim” induced the virtue of ‘responsibility’ from the medical students. Consequently, “Lord Jim” could be good teaching material for medical humanities. PMID:25417908

  10. Medical doctors as the captain of a ship: an analysis of medical students’ book reports on Joseph Conrad’s “Lord Jim”

    Directory of Open Access Journals (Sweden)

    Kun Hwang

    2014-11-01

    Full Text Available Purpose: In South Korean ferry disaster in 2014, the captain abandoned the ship with passengers including high school students still aboard. We noticed the resemblance of abandoning the ship with passengers still aboard the ferry (named the Sewol and the ship Patna, which was full of pilgrims, in Joseph Conrad’s novel “Lord Jim.” The aim of this study is to see how medical students think about the role of a medical doctor as a captain of a ship by analyzing book reports on Conrad’s “Lord Jim.” Methods: Participants included 49 third-year medical students. Their book reports were analyzed. Results: If placed in the same situation as the character of Jim, 24 students of the 49 respondents answered that they would stay with the passengers, while 18 students indicated they would escape from the ship with the crew. Most of the students thought the role of a doctor in the medical field was like that of a ‘captain.’ The medical students reported that they wanted to be a doctor who is responsible for his or her patients, highly moral, warm-hearted, honest, and with high self-esteem. Conclusion: In conclusion, we found that “Lord Jim” induced the virtue of ‘responsibility’ from the medical students. Consequently, “Lord Jim” could be good teaching material for medical humanities.

  11. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. Govindasamy Kumaramanickavel. Articles written in Journal of Genetics. Volume 81 Issue 1 April 2002 pp 19-23 Perspectives. RPE65 gene: multiplex PCR and mutation screening in patients from India with retinal degenerative diseases · Biju Joseph Anuradha Srinivasan Nagasamy ...

  12. Fermi/GBM Update on the Orbital Ephemeris of Swift J0243.6+6124

    Science.gov (United States)

    Jenke, P.; Wilson-Hodge, C. A.; Malacaria, C.

    2018-02-01

    Using Fermi/GBM data between MJD 58098 and 58154 (2017 December 11 to 2018 February 5) in the 12-50 keV range, we determine a new orbital ephemeris for the newly discovered (ATEL #10809) Be X-ray binary Swift J0243.6+6124.

  13. Newton da Costa and the school of Curitiba

    Directory of Open Access Journals (Sweden)

    Artibano Micali

    2011-06-01

    Full Text Available This paper intends to report on the beginning of the publications of Newton da Costa outside Brazil. Two mathematicians played an important role in this beginning: Marcel Guillaume from the University of Clermont-Ferrand and Paul Dedecker from the Universities of Lille and Liège. At the same time we recall the role played by Newton da Costa and Jayme Machado Cardoso in the development of what we call here the School of Curitiba [Escola de Curitiba]. Paraconsistent logic was initiated in this school under the influence of Newton da Costa. As another contribution of this school we mention the development of the theory of quasigroups; Jayme Machado Cardoso's name has been given, by Sade, to some particular objects which are now called Cardoso quasigroups.

  14. “Pai contra mãe”: quando o outro não é semelhante

    Directory of Open Access Journals (Sweden)

    Robson de Freitas Pereira

    Full Text Available Resumo Através da ficção de Machado de Assis, buscamos mostrar o quanto permanecem atuais certos comportamentos e formas de subjetividade herdeiros da escravidão. Essa herança está incorporada ao discurso social e na linguagem cotidiana. Ela se transforma segundo as condições atuais, mas não se apaga. O reconhecimento da impossibilidade desse apagamento é uma chance para sua superação. A escrita de Machado transforma-se em ferramenta significativa para a elaboração e prática dos psicanalistas, uma vez que, para a psicanálise, o exercício de sua ética não está dissociado da escuta dos discursos que organizam a subjetividade em seu tempo e lugar.

  15. High-power diode-end-pumped Tm:YLF slab laser delivering 189 W at 1890 nm

    CSIR Research Space (South Africa)

    Koen, W

    2010-09-01

    Full Text Available Laser Delivering 189 W at 1890 nm W. Koen, H.J. Strauss, C. Bollig and M.J.D. Esser CSIR National Laser Centre, Meiring Naude Road, Brummeria, Pretoria, 0001 wkoen@csir.co.za Abstract: We present a high-power Tm:YLF slab laser double...

  16. 96 International Conference on Nonlinear Programming

    CERN Document Server

    1998-01-01

    About 60 scientists and students attended the 96' International Conference on Nonlinear Programming, which was held September 2-5 at Institute of Compu­ tational Mathematics and Scientific/Engineering Computing (ICMSEC), Chi­ nese Academy of Sciences, Beijing, China. 25 participants were from outside China and 35 from China. The conference was to celebrate the 60's birthday of Professor M.J.D. Powell (Fellow of Royal Society, University of Cambridge) for his many contributions to nonlinear optimization. On behalf of the Chinese Academy of Sciences, vice president Professor Zhi­ hong Xu attended the opening ceremony of the conference to express his warm welcome to all the participants. After the opening ceremony, Professor M.J.D. Powell gave the keynote lecture "The use of band matrices for second derivative approximations in trust region methods". 13 other invited lectures on recent advances of nonlinear programming were given during the four day meeting: "Primal-dual methods for nonconvex optimization" by...

  17. Chronic disease self-management support for persons with dementia, in a clinical setting

    Directory of Open Access Journals (Sweden)

    Ibrahim JE

    2017-01-01

    Full Text Available Joseph Elias Ibrahim,1 Laura J Anderson,1 Aleece MacPhail,2 Janaka Jonathan Lovell,2 Marie-Claire Davis,1 Margaret Winbolt3 1Department of Forensic Medicine, Monash University, Southbank, 2Ballarat Health Services, Ballarat, 3Australian Centre for Evidence Based Aged Care, College of Science, Health and Engineering, La Trobe University, Melbourne, VIC, Australia Abstract: The burden of chronic disease is greater in individuals with dementia, a patient group that is growing as the population is aging. The cornerstone of optimal management of chronic disease requires effective patient self-management. However, this is particularly challenging in older persons with a comorbid diagnosis of dementia. The impact of dementia on a person’s ability to self-manage his/her chronic disease (eg, diabetes mellitus or heart failure varies according to the cognitive domain(s affected, severity of impairment and complexity of self-care tasks. A framework is presented that describes how impairment in cognitive domains (attention and information processing, language, visuospatial ability and praxis, learning and memory and executive function impacts on the five key processes of chronic disease self-management. Recognizing the presence of dementia in a patient with chronic disease may lead to better outcomes. Patients with dementia require individually tailored strategies that accommodate and adjust to the individual and the cognitive domains that are impaired, to optimize their capacity for self-management. Management strategies for clinicians to counter poor self-management due to differentially impaired cognitive domains are also detailed in the presented framework. Clinicians should work in collaboration with patients and care givers to assess a patient’s current capabilities, identify potential barriers to successful self-management and make efforts to adjust the provision of information according to the patient’s skill set. The increasing prevalence of

  18. Umbilical metastasis (Sister Mary Joseph's nodule diagnosed by fine-needle aspiration

    Directory of Open Access Journals (Sweden)

    Tatomirović Željka

    2004-01-01

    Full Text Available Sister Mary Joseph’s nodule is the eponym for metastatic involvement of the umbilicus. This less common entity is the sign of disseminated malignant disease, mainly of digestive and gynecologic origin, and is associated with a poor prognosis. A case of Sister Mary Joseph’s nodule in a 76-year-old woman in whom the umbilical metastasis was the first sign of malignant disease in presented. The diagnosis of metastatic adenocarcinoma was established by fine needle aspiration cytology of the umbilical nodule. Radiological and ultrasonographic investigation disclosed carcinoma of the gallbladder with pancreas, stomach, and colon invasion as well as peritoneal dissemination. The diagnosis was confirmed by exploratory laparatomy and histological examination of the excised umbilical nodule.

  19. Application of the FluEgg model to predict transport of Asian carp eggs in the Saint Joseph River (Great Lakes tributary)

    Science.gov (United States)

    Garcia, Tatiana; Murphy, Elizabeth A.; Jackson, P. Ryan; Garcia, Marcelo H.

    2015-01-01

    The Fluvial Egg Drift Simulator (FluEgg) is a three-dimensional Lagrangian model that simulates the movement and development of Asian carp eggs until hatching based on the physical characteristics of the flow field and the physical and biological characteristics of the eggs. This tool provides information concerning egg development and spawning habitat suitability including: egg plume location, egg vertical and travel time distribution, and egg-hatching risk. A case study of the simulation of Asian carp eggs in the Lower Saint Joseph River, a tributary of Lake Michigan, is presented. The river hydrodynamic input for FluEgg was generated in two ways — using hydroacoustic data and using HEC-RAS model data. The HEC-RAS model hydrodynamic input data were used to simulate 52 scenarios covering a broad range of flows and water temperatures with the eggs at risk of hatching ranging from 0 to 93% depending on river conditions. FluEgg simulations depict the highest percentage of eggs at risk of hatching occurs at the lowest discharge and at peak water temperatures. Analysis of these scenarios illustrates how the interactive relation among river length, hydrodynamics, and water temperature influence egg transport and hatching risk. An improved version of FluEgg, which more realistically simulates dispersion and egg development, is presented. Also presented is a graphical user interface that facilitates the use of FluEgg and provides a set of post-processing analysis tools to support management decision-making regarding the prevention and control of Asian carp reproduction in rivers with or without Asian carp populations.

  20. Canine and feline obesity: a review of pathophysiology, epidemiology, and clinical management

    OpenAIRE

    Wakshlag, Joseph J; Loftus,John

    2014-01-01

    John P Loftus, Joseph J Wakshlag Cornell University College of Veterinary Medicine, Veterinary Medical Center, Ithaca, NY, USAAbstract: Canine and feline obesity rates have reached pandemic proportions and are similar to those in humans, with approximately 30%–40% of dogs and cats being overweight to obese. Obesity has been associated with other health problems, including osteoarthritis, renal disease, skin disease, insulin resistance, and neoplasia in dogs, while in cats obesity is...

  1. Case report

    African Journals Online (AJOL)

    abp

    23 juin 2015 ... of coronary steal phenomenon by stress thallium scintigraphy and exercise haeodynamics. Am Heart J. 1990 Jul; 120. (1):217-9. PubMed | Google Scholar. 14. Reidy JF, Jones ODH, Tynan MJ, Baker EJ, Joseph MC. Embolization procedures in congenital heart disease. Br Heart. J. 1985 Aug;54(2):184-92.

  2. Optical photometry and polarimetry of GX 339-4 during its outburst rise

    NARCIS (Netherlands)

    Russell, D.M.; Lewis, F.; Casella, P.; Pretorius, M.L.; Fender, R.P.; Roche, P.; Clark, S.

    2009-01-01

    GX 339-4 is currently brightening at X-ray, UV, optical and radio frequencies (ATel #1945, #1954, #1960). Our monitoring campaign with the Faulkes Telescope South (ATel #1586) gives the following recent magnitudes (light curves are below; errors are ~ 0.02 mag): 2009-02-20 (MJD 54882.65): i' ~ 16.66

  3. Catholic Enlightenment for children. Teaching religion to children in the Habsburg Empire from Joseph II to the Restoration

    Directory of Open Access Journals (Sweden)

    Simonetta Polenghi

    2016-05-01

    Full Text Available During Joseph II’s reign a deep cultural shift took place within the intellectual and religious establishment, with the acceptance of philosophical and pedagogical ideas that bore a distinctive Enlightenment and Protestant stamp. This cultural shift was applied to the teaching of religion by some relevant figures of the episcopal and pedagogical elites (J. A. Gall, F.M. Vierthaler, F. de Paula Gaheis, J. M. Leonhard. New handbooks and textbooks of the catechism were written which introduced new dialogic methods, more narrative, and borrowed Rochow’s typology of moral short stories. The content of Bishop Gall’s books was heavily rationalistic, whereas subsequent texts tried to balance reason and faith. Vierthaler, Gaheis, and Leonhard used a language that was more suitable for children and closer to the New Testament, with the use of parables and short stories. The so-called Socratic method was used in different ways by these authors.In the age of the Restoration, in spite of the process of school confessionalization, the heritage of the spirit of Enlightenment was still present, since by law the pedagogy taught in the Empire’s academic chairs and teacher training courses was the one defined by Milde, which bore a Kantian imprint, and stressed the importance of developing inner moral law in pupils. Leonhard was a follower of Milde, and his catechism, eventually approved for elementary schools for decades, bore this stamp.So at the end of the eighteenth and the beginning of the nineteenth centuries a new way of teaching religion was introduced, debated and contested in Habsburg Catholic territories. Rousseau’s and Salzmann’s theories were discussed; rationalism and faith, natural religion and revelation were confronted. In the end more attention was devoted to child psychology and language. The cultural fracture caused by Josephinism became less severe: orthodoxy was restored, but new pedagogical ideas actually entered the teaching of

  4. Babesiosis in Lower Hudson Valley, New York

    Centers for Disease Control (CDC) Podcasts

    2011-05-12

    This podcast discusses a study about an increase in babesiosis in the Lower Hudson Valley of New York state. Dr. Julie Joseph, Assistant Professor of Medicine at New York Medical College, shares details of this study.  Created: 5/12/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 5/23/2011.

  5. Osmotic stress upregulates the transcription of thiamine (vitamin B1 ...

    African Journals Online (AJOL)

    Syamimi Mimi

    2016-07-20

    Jul 20, 2016 ... damage tolerance when subjected to abiotic stress. (Machado et al. ... µg/µl of total RNA, 4 µl of 5× Reverse Transcriptase Buffer, 1 µl of 10 mM ..... facilitate vitamin B1 biofortification of plants by genetic engineering;. Front.

  6. Case report

    African Journals Online (AJOL)

    ebutamanya

    2015-11-24

    Nov 24, 2015 ... 2006 ; 131(8) :464-467. PubMed | Google. Scholar. 3. Ferreira Sheila S, Werutsky Gustavo, Toneto Marcelo Garcia,. Alves Jarcedy Machado, Piantáemail Christina Duarte, Breunig. Raquel Cristine, Brondani da Rocha Adriana, Griviciche Ivana,. Garicochea Bernardo. Synchronous gastrointestinal stromal.

  7. INTEGRAL observations of SAX J1808.4-3658 currently in outburst

    DEFF Research Database (Denmark)

    Del Santo, M.; Bozzo, E.; Kuulkers, E.

    2015-01-01

    The latest INTEGRAL Galactic Bulge monitoring (ATel #438) was performed during revolution 1529 on 2015 April 12 starting at 18:15 UT (57124.761 MJD) for a total of 12462 seconds. We report on the IBIS/ISGRI detection of the new outburst from the millisecond X-ray pulsar SAX J1808.4-3658 (ATels...

  8. A flat radio spectrum of MAXI J1820+070

    Science.gov (United States)

    Trushkin, S. A.; Nizhelskij, N. A.; Tsybulev, P. G.; Erkenov, A.

    2018-03-01

    We have observed the new X-ray transient MAXI J1820+070 (ATel #11399, #11400, #11403, #11404, #11406, #11418, #11421, #11423, #11424, #11426, #11427, #11432, #11437) with the RATAN-600 radio telescope (SAO RAS, http://www.sao.ru) at 4.7, 8.2 and 11.2 GHz on March 18 2018 (MJD 58195.161).

  9. The impact of education on wage determination between workers in southern and central-northern Italy

    Directory of Open Access Journals (Sweden)

    Agovino Massimiliano

    2016-01-01

    Full Text Available The aim of this paper is to examine the earnings dynamic in Italy, in order to explain earnings differences between southern Italy and centralnorthern Italy. In our analysis we use different techniques: ordinary least squares (OLS, quantile regression models and the algorithm developed by Machado and Mata (2005. In particular, the Machado and Mata (2005 algorithm allows us to examine the relative importance of both differences in workers’ characteristics and in their returns in explaining southern, central and northern Italy earnings differences at a point in time, as well as across time within each macro-area. We focus on the role of differences in educational endowment and returns to education, one of the most important components of human capital in the stylised literature. The level of education determines the substantial disparities in terms of wage returns. However, this holds only for levels of education related to compulsory education.

  10. Decomposing wage distributions on a large data set - a quantile regression analysis of the gender wage gap

    DEFF Research Database (Denmark)

    Albæk, Karsten; Brink Thomsen, Lars

    This paper presents and implements a procedure that makes it possible to decompose wage distributions on large data sets. We replace bootstrap sampling in the standard Machado-Mata procedure with ‘non-replacement subsampling’, which is more suitable for the linked employer-employee data applied i...... in gender wage differences in the lower part of the wage distribution.......This paper presents and implements a procedure that makes it possible to decompose wage distributions on large data sets. We replace bootstrap sampling in the standard Machado-Mata procedure with ‘non-replacement subsampling’, which is more suitable for the linked employer-employee data applied...... in this paper. Decompositions show that most of the glass ceiling is related to segregation in the form of either composition effects or different returns to males and females. A counterfactual wage distribution without differences in the constant terms (or ‘discrimination’) implies substantial changes...

  11. Simultaneous measurement of free-living energy expenditure by the doubly labeled water method and heart-rate monitoring

    International Nuclear Information System (INIS)

    Livingstone, M.B.; Prentice, A.M.; Coward, W.A.; Ceesay, S.M.; Strain, J.J.; McKenna, P.G.; Nevin, G.B.; Barker, M.E.; Hickey, R.J.

    1990-01-01

    Total energy expenditure (TEE) was measured simultaneously in 14 free-living adults over 15 d by the doubly labeled water (DLW) method and for 2-4 separate days by heart-rate (HR) monitoring. Individual curves for HR vs oxygen consumption (VO2) were obtained and an HR (FLEX HR: 97 +/- 8 beats/min, range 84-113 beats/min) that discriminated between rest and activity was identified. Calibration curves were used to assign an energy value to daytime HR above FLEX HR. Below FLEX HR energy expenditure was taken as resting metabolism. Sleeping energy expenditure was assumed to be equal to basal metabolic rate. Average HR TEE (12.99 +/- 3.83 MJ/d) and average DLW TEE (12.89 +/- 3.80 MJ/d) were similar. HR TEE discrepancies ranged from -22.2% to +52.1%, with nine values lying within +/- 10% of DLW TEE estimates. The FLEX HR method provides a close estimation of the TEE of population groups. However, an increased number of sampling days may improve the precision of individual estimates of TEE

  12. Minnesota leisure time activity questionnaire and doubly labeled water in adolescents.

    Science.gov (United States)

    Slinde, Frode; Arvidsson, Daniel; Sjöberg, Agneta; Rossander-Hulthén, Lena

    2003-11-01

    To validate the energy expenditure estimated from The Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) with total energy expenditure (TEE) measured by doubly labeled water (DLW), and to present and examine the validity of an extended version of the MLTPAQ with additional questions about inactivity during leisure time (eMLTPAQ), in a sample of Swedish 15-yr-old adolescents. Thirty-five 15-yr-old adolescents were interviewed using the eMLTPAQ. In addition to anthropometry, indirect calorimetry was measured to assess basal metabolic rate, and TEE was assessed by the DLW method over a 14-d period. Energy expenditure calculated from MLTPAQ correlated well with TEEDLW (r=0.49, Pstudents, with a mean difference between the methods of 2.8 MJ.d(-1) (95% limits of agreement: -0.1 to 5.6 MJ.d(-1)), which mainly was explained by a relative high intensity in the time which remained unreported. eMLTPAQ is valid in ranking adolescents energy expenditure and in describing patterns of leisure time physical activities.

  13. Phylloquinone content from wild green vegetables may contribute substantially to dietary intake

    DEFF Research Database (Denmark)

    Bügel, Susanne Gjedsted; Spagner, Camilla; Poulsen, Sanne Kellebjerg

    2016-01-01

    Background: Traditional Nordic eatable wild plants are now sold in local stores and available to everyone. Wild vegetables may contain large amounts of vitamin K1. Due to the concomitant therapeutic use of anticoagulants among the populations, it is important to gain knowledge about the content...... phylloquinone content of 400-600 μg vitamin K1/100 g fresh weight. The average daily intake when consuming the average Danish diet is low (64 ±20 μg/d or 72±23 μg/10 MJ/d), however, inclusion of wild vegetables as in the New Nordic Diet increases the vitamin K1 intake to 233±51 μg/d or 260±50 μg/10 MJ/d...... of vitamin K1 in these products, as well as their contribution to the diet. The objective of this study was to measure the vitamin K1 content in four wild eatable plants and to estimate how much these wild vegetables contribute to the daily dietary vitamin K1 intake. Results: The wild vegetables had a high...

  14. Carbohydrate-restricted diets high in either monounsaturated fat or protein are equally effective at promoting fat loss and improving blood lipids.

    Science.gov (United States)

    Luscombe-Marsh, Natalie D; Noakes, Manny; Wittert, Gary A; Keogh, Jennifer B; Foster, Paul; Clifton, Peter M

    2005-04-01

    When substituted for carbohydrate in an energy-reduced diet, dietary protein enhances fat loss in women. It is unknown whether the effect is due to increased protein or reduced carbohydrate. We compared the effects of 2 isocaloric diets that differed in protein and fat content on weight loss, lipids, appetite regulation, and energy expenditure after test meals. This was a parallel, randomized study in which subjects received either a low-fat, high-protein (LF-HP) diet (29 +/- 1% fat, 34 +/- 0.8% protein) or a high-fat, standard-protein (HF-SP) diet (45 +/- 0.6% fat, 18 +/- 0.3% protein) during 12 wk of energy restriction (6 +/- 0.1 MJ/d) and 4 wk of energy balance (7.4 +/- 0.3 MJ/d). Fifty-seven overweight and obese [mean body mass index (in kg/m(2)): 33.8 +/- 0.9] volunteers with insulin concentrations >12 mU/L completed the study. Weight loss (LF-HP group, 9.7 +/- 1.1 kg; HF-SP group, 10.2 +/- 1.4 kg; P = 0.78) and fat loss were not significantly different between diet groups even though the subjects desired less to eat after the LF-HP meal (P = 0.02). The decrease in resting energy expenditure was not significantly different between diet groups (LF-HP, -342 +/- 185 kJ/d; HF-SP, -349 +/- 220 kJ/d). The decrease in the thermic effect of feeding with weight loss was smaller in the LF-HP group than in the HF-SP group (-0.3 +/- 1.0% compared with -3.6 +/- 0.7%; P = 0.014). Glucose and insulin responses to test meals improved after weight loss (P loss and the improvements in insulin resistance and cardiovascular disease risk factors did not differ significantly between the 2 diets, and neither diet had any detrimental effects on bone turnover or renal function.

  15. Insights into the microbiota of the bovine uterus

    DEFF Research Database (Denmark)

    Rødtness Vesterby Knudsen, Lif; Christensen Karstrup, Cecilia; Gervi Pedersen, Hanne

    (Machado et al. 2012 and Galvão et al. 2012) while Escherichia coli, Trueperella Pyogenes, Prevotella species and Fusobacterium necrophorum have commonly been associated with endometritis (Sheldon 2006). Preliminary results indicate that we often find bacteria from phylum Actinobacteria in the healthy cows...

  16. Swift/BAT confirms the giant outburst of H 1417-624

    Science.gov (United States)

    Krimm, H. A.; Barthelmy, S. D.; Cummings, J. R.; Lien, A. Y.; Markwardt, C. B.; Palmer, D. M.; Sakamoto, T.; Stamatikos, M.; Ukwatta, T. N.

    2018-04-01

    The Swift/BAT transient monitor confirms the current outburst from the Be/X-ray binary pulsar, H 1417-624 ( = 2S 1417-624) (Nakajima et al., ATel #11479). In the BAT 15-50 keV energy band, the outburst began approximately on 20 March 2018 (MJD 57467) and the count rate has been steadily rising since that time.

  17. Prevalence of comorbid retinal disease in patients with glaucoma at an academic medical center

    Directory of Open Access Journals (Sweden)

    Griffith JF

    2015-07-01

    Full Text Available Joseph F Griffith,1 Jeffrey L Goldberg2 1Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, 2Shiley Eye Center, University of California San Diego, La Jolla, CA, USA Background: Patients with various retinal diseases and patients who have undergone retinal procedures and surgeries have an increased risk of developing ocular hypertension and glaucoma. Little is known about the epidemiology of comorbid retinal diseases in glaucoma patients. This study evaluated the prevalence of retinal comorbidities in a population of patients with five types of glaucoma.Methods: A longitudinal, retrospective study was conducted using International Classification of Disease (ICD-9 billing records from 2003 to 2010 at an academic medical center. Patients were classified as having primary open-angle glaucoma (POAG, low tension open-angle glaucoma (NTG, pigmentary open-angle glaucoma, chronic-angle closure glaucoma (CACG, or pseudoexfoliation glaucoma (PXG if they had at least three clinic visits with the same ICD-9 code. Patients were classified as having a retinal comorbidity if they had two visits with the same code. Variables were analyzed with the independent t-test, χ2 test, analysis of variance, or Fisher’s exact test.Results: A total of 5,154 patients had glaucoma, and 14.8% of these had a retinal comorbidity. The prevalence of comorbid retinal disease was higher in patients with POAG (15.7% than in those with NTG (10.7%, PXG (10.1%, or pigmentary open-angle glaucoma (3.7%; P<0.05. Two hundred and two patients had diabetic retinopathy, with POAG patients (4.5% having a higher prevalence than those with CACG (1.4% or PXG (0.6%; P<0.001. There were 297 patients who had macular degeneration and both POAG (2.0% and PXG patients (2.9% had a higher prevalence of nonexudative macular degeneration than those with CACG (0%; P<0.01. Patients with comorbid retinal disease had a higher prevalence of blindness and low vision than those without comorbid

  18. Chronic obstructive pulmonary disease as an independent risk factor for cardiovascular morbidity

    Directory of Open Access Journals (Sweden)

    Joseph Finkelstein

    2009-09-01

    Full Text Available Joseph Finkelstein1, Eunme Cha1, Steven M Scharf 21Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA; 2Division of Pulmonary and Critical Care Medicine at the Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USARationale: Recent studies described association between chronic obstructive pulmonary disease (COPD and increased risk of cardiovascular diseases (CVD. In their analysis none of these studies accounted for sociodemographic factors, health behaviors, and patient comorbidities simultaneously.Objective: To study whether COPD diagnosis is an independent risk factor for CVD. Methods: Subjects aged 40 years and older (N = 18,342 from the sample adult file of the 2002 National Health Interview Survey (NHIS were included in the analysis. Chi-squared tests and odds ratios (OR were utilized to compare the data. Multiple logistic regression was employed to analyze the association between COPD and CVD with simultaneous control for sociodemographic factors (age, gender, race, marital status, education, income, health behaviors (tobacco use, alcohol consumption, physical activity, and patient comorbidities (diabetes, hypertension, high cholesterol, and obesity. The analysis employed NHIS sampling weights to generate data representative of the entire US population.Results: The COPD population had increased prevalence of CVD (56.5% vs 25.6%; P < 0.0001. Adjusted logistic regression showed that COPD patients (N = 958 were at higher risk of having coronary heart disease (OR = 2.0, 95% CI: 1.5–2.5, angina (OR = 2.1, 95% CI: 1.6–2.7, myocardial infarction (OR = 2.2, 95% CI: 1.7–2.8, stroke (OR = 1.5, 95% CI: 1.1–2.1, congestive heart failure (OR = 3.9, 95% CI: 2.8–5.5, poor circulation in lower extremities (OR = 2.5, 95% CI: 2.0–3.0, and arrhythmia (OR = 2.4, 95% CI: 2.0–2.8. Overall, the presence of COPD increased the odds of having CVD by a factor of

  19. A designated centre for people with disabilities operated by St Joseph's Foundation, Cork

    LENUS (Irish Health Repository)

    McNabola, Aonghus

    2009-02-01

    According to World Health Organisation figures, 30% of all cancer deaths, 20% of all coronary heart diseases and strokes and 80% of all chronic obstructive pulmonary disease are caused by cigarette smoking. Environmental Tobacco Smoke (ETS) exposure has also been shown to be associated with disease and premature death in non-smokers. In response to this environmental health issue, several countries have brought about a smoking ban policy in public places and in the workplace. Countries such as the U.S., France, Italy, Ireland, Malta, the Netherlands, Sweden, Scotland, Spain, and England have all introduced policies aimed at reducing the population exposure to ETS. Several investigations have monitored the effectiveness of these smoking ban policies in terms of ETS concentrations, human health and smoking prevalence, while others have also investigated a number of alternatives to smoking ban policy measures. This paper reviews the state of the art in research, carried out in the field of ETS, smoking bans and Tobacco Control to date and highlights the need for future research in the area.

  20. Ethno-religious Identities and Cosmopolitan Echoes in John Updike’s ‘Terrorist’ (2006 and Joseph O’Neill’s ‘Netherland’ (2008

    Directory of Open Access Journals (Sweden)

    Pamela Mansutti

    2011-09-01

    Full Text Available Far from offering a cohesive representation of ethnic and racialized individuals after the terrorist attacks of 9/11, US recent fiction on this particular subject navigates otherness in many contradictory ways, ranging from the resistance to represent, or even think, alterity in literary forms to the desire of exploring, if not mastering it through characterization. The novels here examined, John Updike’s Terrorist (2006 and Joseph O’Neill’s Netherland (2008, deal with the long-term aftermath of 9/11 rather than shaping its symptomatic repercussions in the days following the attacks. Yet, Updike and O’Neill pick up on the dualisms that run across early post-9/11 America and represent, though in ways that are at largely at odds, the impossibility for (either naturalized or immigrant ethnic subjects to suture their own identity to the fabric of American society. Theirs are stories of naiveté and exclusion that convey a rather pessimistic vision of multiculturalism in the twenty-first-century US society. In both Updike and O’Neill’s novels, 9/11 has augmented social tensions and racial hatred: on the one hand, mainstream white America appears self-absorbed and depressed, unable to open up fully to the unfit or the different; on the other hand, racialized individuals are depicted in an ambivalent light and are in the end doomed because of their blind and staunch faith, regardless whether it is pinned on Islam or the American dream. This would leave us with a rather bleak picture if it were not for the fact that the “white gazes” that shape the novels cast a benign, sympathetic light on the ethnic characters by turning them into victims of their own intransigence and of even larger systemic forces beyond their control.

  1. New species of Pseudagrion ( Odonata: Zygoptera) with descriptions of the larvae of five other species belonging to the genus

    CSIR Research Space (South Africa)

    Chutter, FM

    1962-01-01

    Full Text Available certaiaes conversions et sur Ia dimension de l?erreur de copie chez I?Ascobolus immersus. e outros trabalhos prometidos, mas que ainda n?o entraram para publica?ao. EDITORES C. CHAGAS A. DE B. MACHADO INSTITUT() BE BlO-EISICA MUSEU DO DUNDO AVENIDA...

  2. Browse Title Index - AJOL

    African Journals Online (AJOL)

    Items 6401 - 6450 of 11090 ... ... Tatiana Marquini Machado, Natalia Reis Furtado, Luciana Francisco Fleuri, Marizete Cavalcante de Souza Vieira, Luciana Manoel Oliveira, Fabio ... Cecília Maria de Carvalho Xavier Holanda, Janette Monroy Osório, Tarciso Bruno Montenegro Sampaio, Christina da Silva Camillo, Aldo Cunha ...

  3. Castas estrelas! Chaste stars

    Directory of Open Access Journals (Sweden)

    Regina Andrade

    1999-01-01

    Full Text Available Este trabalho é uma parte da pesquisa Processos de Adaptações Criativas - Cinema Literário e Psicanálise, cujo objetivo principal é a análise específica da linguagem e das transformações sofridas pelos textos literários quando da passagem para textos fílmicos. Apresento como exemplo o filme Quincas Borba (dirigido por Roberto Santos, baseado no livro homônimo de Machado de Assis.This paper is the abridgment of the research Processos de Adaptações Criativas - Cinema Literário e Psicanálise (Creative Adaptation Processes - Literary Cinema and Psychoanalysis, which main goal is the specific analysis of language as well as of the transformations undergone by literary texts in their translation to filmic texts. I present as an example the movie Quincas Borba (directed by Roberto Santos, based on the homonymous book by Machado de Assis.

  4. LITERATURA NA ESCOLA: ENTRE O REAL E O POSSÍVEL

    Directory of Open Access Journals (Sweden)

    Flávia Brocchetto Ramos

    2008-11-01

    Full Text Available As práticas de leitura literária geralmente não respeitam as especificidades deste texto, basta observar o tratamento que a literatura recebe, por exemplo, na maioria dos livros didáticos. Além disso, pesquisa realizada com estudantes de 3ª série sinaliza que essas crianças conhecem, predominantemente, literatura de massa. Frente a essa situação, como parte de estudos do projeto “Formação do leitor: o processo de mediação docente”, apresenta-se Machado de Assis como um autor que pode fazer parte do repertório de estudantes do Ensino Fundamental. Se Machado é um expoente da Literatura Brasileira, deveria estar presente nos planejamentos dos docentes das escolas brasileiras. Neste artigo, elegem-se algumas narrativas curtas do autor para adentrar as práticas de educação literária.

  5. Adolfo Casais Monteiro y la literatura española / Adolfo Casais Monteiro and sapanish literature.

    Directory of Open Access Journals (Sweden)

    Antonio Sáez Delgado

    2012-06-01

    Full Text Available Resumen: El escritor Adolfo Casais Monteiro, una de las figuras más importantes del denominado 2º Modernismo portugués, se interesó por la obra de algunos escritores españoles de las primeras décadas del siglo XX, como Antonio Machado o Benjamín Jarnés. Estas relaciones sirven para demostrar que el diálogo establecido alrededor de la línea cronológica establecida entre la Generación del 27 española y el 2º Modernismo portugués produjo algunos resultados significativos. Abstract: Adolfo Casais Monteiro, one of the most important names of the "Second Portuguese Modernism", was interested in the works of some of the Spanish writers of the early 20th century such as Antonio Machado and Benjamín Jarnés. These relationships demonstrate that the dialogue between the timeline established by the Spanish Generation of '27 and the Second Portuguese Modernism produced some significant results.

  6. Validation of celiac disease diagnoses recorded in the Danish National Patient Register using duodenal biopsies, celiac disease-specific antibodies, and human leukocyte-antigen genotypes

    Directory of Open Access Journals (Sweden)

    Dydensborg Sander S

    2016-12-01

    Full Text Available Stine Dydensborg Sander,1-3 Ketil Størdal,4,5 Tine Plato Hansen,6 Anne-Marie Nybo Andersen,7 Joseph A Murray,8 Søren Thue Lillevang,9 Steffen Husby1,2 1Hans Christian Andersen Children’s Hospital, Odense University Hospital, 2Institute of Clinical Research, University of Southern Denmark, 3Odense Patient Data Explorative Network (OPEN, Odense University Hospital, Odense, Denmark; 4Mental and Physical Health, Norwegian Institute of Public Health, Oslo, 5Department of Pediatrics, Ostfold Hospital Trust, Fredrikstad, Norway; 6Department of Pathology, Hvidovre Hospital, 7Department of Public Health, University of Copenhagen, Copenhagen, Denmark; 8Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA; 9Department of Clinical Immunology, Odense University Hospital, Odense, Denmark Purpose: The purpose of this study was to validate the celiac disease diagnoses recorded in the Danish National Patient Register. To validate the diagnoses, we used information on duodenal biopsies from a national register of pathology reports (the Patobank and information on celiac disease-specific antibodies and human leukocyte antigen (HLA genotypes obtained from patient medical records.Patients and methods: We included all the children who were born from 1995 to 2012 and who were registered as having celiac disease in the Danish National Patient Register. We reviewed all the pathology reports on duodenal biopsies in the Patobank and the information in the medical records on celiac disease-specific antibodies (ie, anti-tissue transglutaminase 2 IgA and IgG, endomysial antibodies IgA, and anti-deamidated gliadin peptide IgG and HLA genotypes.Results: We identified 2,247 children who were registered in the Danish National Patient Register with celiac disease. Duodenal biopsies for 1,555 of the children (69% were registered in the Patobank; 1,127 (50% had a biopsy that was compatible with celiac disease (ie, Marsh 2–3. We accessed the medical

  7. La escultura sagrada chocó en el contexto de la memoria de la estética de África y su diáspora: ritual y arte

    NARCIS (Netherlands)

    Machado Caicedo, M.L.

    2011-01-01

    Martha Luz Machado Caicedo bestudeerde de rituele beeldhouwkunst van de Chocó, een indiaanse bevolkingsgroep uit Colombia die in het kustgebied van de Stille Oceaan leeft. Ze geeft een analyse van de esthetica en geschiedenis van de Chocó, en een verkenning van het in hun houtsnijwerk weergegeven

  8. Optimal concentration of selective agents for inhibiting in vitro ...

    African Journals Online (AJOL)

    Alessandra

    (Murashige and Skoog, 1962) supplemented with 30 g/L sucrose, 3 mg/L 2 ... was adjusted to 5.8 ± 0.1 and autoclaved for 20 min at 121 ± 1°C. Ten seeds were ..... Takamori LM, Machado Neto NB, Vieira LGE, Ribas AF (2015). Optimization of ...

  9. Socializing doings, exchanging ideas and expanding knowledge

    Directory of Open Access Journals (Sweden)

    Marlene Luiz

    2009-01-01

    Full Text Available This text is the result of discussions of the Group Study in Kindergarten Machado de Assis, which represents one of the spaces in-service training. The goal will be to share a little tissue movement in groups throughout the sessions that took place during 2009.

  10. Non-covalent O⋅⋅⋅O interactions among isopolyanions using a cis ...

    Indian Academy of Sciences (India)

    WINTEC

    2008-05-09

    May 9, 2008 ... T Arumuganathan et al. 298 ... Sodium molybdate dihydrate (1 g, 4⋅13 mmol) was dissolved in 20 mL of ..... Int. Ed. Engl. 32 610; Kroenke Jr J W, John P F and. Anthony M M .... D, Machado A S, Tempete C and Robert-Gero M.

  11. Timing irregularities of PSR J1705-1906

    Science.gov (United States)

    Liu, Y. L.; Yuan, J. P.; Wang, J. B.; Liu, X. W.; Wang, N.; Yuen, R.

    2018-05-01

    Timing analysis of PSR J1705-1906 using data from Nanshan 25-m and Parkes 64-m radio telescopes, which span over fourteen years, shows that the pulsar exhibits significant proper motion, and rotation instability. We updated the astrometry parameters and the spin parameters of the pulsar. In order to minimize the effect of timing irregularities on measuring its position, we employ the Cholesky method to analyse the timing noise. We obtain the proper motion of -77(3) mas yr-1 in right ascension and -38(29) mas yr-1 in declination. The power spectrum of timing noise is analyzed for the first time, which gives the spectral exponent α =-5.2 for the power-law model indicating that the fluctuations in spin frequency and spin-down rate dominate the red noise. We detect two small glitches from this pulsar with fractional jump in spin frequency of Δ ν /ν ˜ 2.9 × 10^{-10} around MJD 55199 and Δ ν /ν ˜ 2.7× 10^{-10} around MJD 55953. Investigations of pulse profile at different time segments suggest no significant changes in the pulse profiles around the two glitches.

  12. PERFORMANCE OPTIMIZATION OF COGNITIVE RADIO WITH WIDEBAND SPECTRUM SENSING

    Directory of Open Access Journals (Sweden)

    E. Saraniya

    2014-09-01

    Full Text Available Cognitive radio (CR technology allows the unlicensed user to access the licensed spectrum bands. Spectrum sensing is an essential function in cognitive radio to detect the spectrum holes and opportunistically use the underutilized frequency bands without causing interference to primary user (PU. In this paper we are maximizing the throughput capacity of cognitive radio user and hence the performance of spectrum sensing and protection to licensed user improves over a wideband spectrum sensing band. The simulation of cognitive radio is done by analyzing the performance of energy detector spectrum sensing technique to detect primary user and to formulate the optimization using multiband joint detection method (MJD to achieve suitable trade- off between secondary user access and primary user network. The main aim of this paper is to maximize the probability of detection and to decrease the probabilities of miss detection and false alarm. To maximize the throughput it requires minimizing the throughput loss caused by miss detection and the significant reduction in probability of false alarm helps in achieving the spectral efficiency from the secondary user’s perspective. The simulation results show that the performance increases with the MJD method.

  13. The optical counterpart of the bright X-ray transient Swift J1745-26

    NARCIS (Netherlands)

    Muñoz-Darias, T.; de Ugarte Postigo, A.; Russell, D.M.; Guziy, S.; Gorosabel, J.; Casares, J.; Armas Padilla, M.; Charles, P.A.; Fender, R.P.; Belloni, T.M.; Lewis, F.; Motta, S.; Castro-Tirado, A.; Mundell, C.G.; Sánchez-Ramirez, R.; Thöne, C.C.

    2013-01-01

    We present a 30-day monitoring campaign of the optical counterpart of the bright X-ray transient Swift J1745−26, starting only 19 min after the discovery of the source. We observe the system peaking at i′ ∼ 17.6 on day six (MJD 561 92) to then decay at a rate of ∼0.04 mag d−1. We show that the

  14. Levodopa/carbidopa and entacapone in the treatment of Parkinson’s disease: efficacy, safety and patient preference

    Directory of Open Access Journals (Sweden)

    Thomas Müller

    2009-01-01

    Full Text Available Thomas Müller1,21Department of Neurology, St. Joseph Hospital Berlin-Weißensee, Berlin, Germany; 2IGSN, Ruhr University of Bochum, Bochum, GermanyAbstract: Levodopa (LD is the oldest, most efficacious and best-tolerated drug for dopaminergic substitution of patients with Parkinson’s disease (PD. Its main drawback is its short half-life, which supports onset of motor complications in the long term. Therefore well-informed PD patients mostly accept LD therapy as late as possible. Recent LD trials indicate that a combination of LD with carbidopa (CD and the catechol-O-methyltransferase (COMT inhibitor entacapone (EN may reduce the onset of these motor complications to a certain extent. This observation is further supported by pharmacokinetic trials and experimental research, but there is still a need to confirm this in a clinical trial, which is under way. Additionally, combined LD/CD/EN was superior to LD/CD administration regarding cognition, muscle behavior and gastrointestinal function in small clinical trials. Moreover there is accumulating evidence that combined COMT inhibition with LD administration reduces homocysteine synthesis. In the long term, homocysteine elevation supports onset of arteriosclerosis-related disorders, which are more frequent in PD patients according to epidemiological studies than in the normal healthy population. The introduction of LD/CD/EN in one tablet supported patients’ preference of COMT inhibition as an essential component of LD/DDI therapy, as this combination reduced number and size of tablets.Keywords: levodopa, entacapone, Parkinson’s disease, preference, compliance, acceptance

  15. In silico prediction of ErbB signal activation from receptor expression ...

    Indian Academy of Sciences (India)

    85

    Annals of biomedical engineering 35 1012-1025. Machado D, Costa RS, Rocha M, Ferreira EC, Tidor B, Rocha I 2011 Modeling formalisms in Systems Biology. AMB Express 1 45. McCabe Pryor M, et al. 2015 Orchestration of ErbB3 signaling through heterointeractions and homointeractions. Mol Biol Cell 26 4109-4123.

  16. Globalized Students vs. Unglobalized Families: Limiting Family Participation in Education

    Science.gov (United States)

    Machado-Casas, Margarita; Ruiz, Elsa

    2012-01-01

    In today's society, the use technology is no longer a luxury but a need (Machado-Casas, 2009; Sanchez, 2010). Considering this, countless education stakeholders have explored the concept of the "digital divide", the gap that exists between people who have access to digital technology and those who do not. Oftentimes, this divide exists…

  17. Computer modeling of obesity links theoretical energetic measures with experimental measures of fuel use for lean and obese men.

    Science.gov (United States)

    Rossow, Heidi A; Calvert, C Chris

    2014-10-01

    The goal of this research was to use a computational model of human metabolism to predict energy metabolism for lean and obese men. The model is composed of 6 state variables representing amino acids, muscle protein, visceral protein, glucose, triglycerides, and fatty acids (FAs). Differential equations represent carbohydrate, amino acid, and FA uptake and output by tissues based on ATP creation and use for both lean and obese men. Model parameterization is based on data from previous studies. Results from sensitivity analyses indicate that model predictions of resting energy expenditure (REE) and respiratory quotient (RQ) are dependent on FA and glucose oxidation rates with the highest sensitivity coefficients (0.6, 0.8 and 0.43, 0.15, respectively, for lean and obese models). Metabolizable energy (ME) is influenced by ingested energy intake with a sensitivity coefficient of 0.98, and a phosphate-to-oxygen ratio by FA oxidation rate and amino acid oxidation rate (0.32, 0.24 and 0.55, 0.65 for lean and obese models, respectively). Simulations of previously published studies showed that the model is able to predict ME ranging from 6.6 to 9.3 with 0% differences between published and model values, and RQ ranging from 0.79 to 0.86 with 1% differences between published and model values. REEs >7 MJ/d are predicted with 6% differences between published and model values. Glucose oxidation increases by ∼0.59 mol/d, RQ increases by 0.03, REE increases by 2 MJ/d, and heat production increases by 1.8 MJ/d in the obese model compared with lean model simulations. Increased FA oxidation results in higher changes in RQ and lower relative changes in REE. These results suggest that because fat mass is directly related to REE and rate of FA oxidation, body fat content could be used as a predictor of RQ. © 2014 American Society for Nutrition.

  18. Adaptation of Physiological and Cognitive Workload via Interactive Multi-modal Displays

    Science.gov (United States)

    2014-05-28

    peer-reviewed journals (N/A for none) 09/07/2013 Received Paper 8.00 James Merlo, Joseph E. Mercado , Jan B.F. Van Erp, Peter A. Hancock. Improving...08, . : , Mr. Joseph Mercado , Mr. Timothy White, Dr. Peter Hancock. Effects of Cross-Modal Sensory Cueing Automation Failurein a Target Detection Task...fields:...... ...... ...... ...... ...... PERCENT_SUPPORTEDNAME FTE Equivalent: Total Number: Discipline Joseph Mercado 0.50 Timothy White 0.50 1.00 2

  19. A toddler with hair fascination.

    Science.gov (United States)

    Kao, Patricia; Needlman, Robert D; Stein, Martin T

    2010-04-01

    Joseph is a 24-months old boy referred by his pediatrician because of an "obsession" with pulling and eating hair. When Joseph was 14 months old, he enjoyed touching and twirling his mother's long hair. She observed that it seemed to provide comfort to him. At 18 months, he initiated pulling out and eating his own hair, twirling his mother's hair around his thumb and then sucking on it. Currently, he searches the carpet or a hard floor and looks for hair to eat. The identical behavior is observed at daycare. Joseph's teacher commented, "He pulled hair from a girl who has the longest hair of all the children. We try to distract him from this habit, but he is not distracted for long." Less frequently, Joseph has also eaten sand, chalk, and crayons at daycare. Joseph's mother describes him as a "happy and outgoing" child who interacts with his peers and has a best friend at the daycare. There have not been recent changes or stressful events in his life. Joseph separates from his mother with ease and he sleeps comfortably through the night in his own bed. There have been no episodes of nausea, vomiting, abdominal pain, or constipation. Strands of hair are occasionally seen in the stool. Prenatal and perinatal history was unremarkable. Joseph was breast-fed for 11 months, described as an "easy" baby, achieved motor, social, and language developmental milestones at the usual time, and has been in excellent health. He lives with his mother and maternal grandparents; the biological father has never been involved in his care. At 20 months, Joseph's pediatrician suggested cutting his hair. After several haircuts, Joseph stopped pulling his own hair. However, he continued to search the floor for hair. Hemoglobin and a blood lead level were normal. Joseph appeared pleasant and friendly with normal growth parameters and facial features. He was sitting comfortably on his mother's lap, sucking on his thumb. Social interactions with his mother were appropriate and reciprocal. He

  20. Chronic obstructive pulmonary disease prevalence in Lebanon: a cross-sectional descriptive study

    Directory of Open Access Journals (Sweden)

    Waked M

    2011-11-01

    Full Text Available Mirna Waked1, George Khayat2, Pascale Salameh31Saint George Hospital University Medical Center, Beirut, Lebanon; 2Faculty of Medicine, Hotel-Dieu de France Hospital, Saint-Joseph University, Beirut, Lebanon; 3Faculties of Pharmacy and Public Health, Lebanese University, Beirut, LebanonBackground: Chronic obstructive pulmonary disease (COPD continues to increase worldwide. The objective of this study was to determine the prevalence of COPD in Lebanese adults.Methods: A cross-sectional study was carried out using a multistage cluster sample from all over Lebanon. Residents aged 40 years and over were enrolled. Subjects underwent baseline spirometry and answered a questionnaire. After an albuterol + ipratropium bromide bronchodilator, a posttest was performed.Results: Of 2201 individuals, only 33.3% had never smoked. The prevalence of COPD by the Global Initiative for Chronic Obstructive Lung Disease definition, was 9.7% (95% confidence interval [CI]: 8.5%–10.9%. According to the 5% lower limit of normal definition of COPD, the prevalence was 12.5% (95% CI: 11.2%–13.9%. A total of 20.2% were already diagnosed by a physician. No differences in symptoms across stages of COPD were found, but there was a significant trend for a higher number of visits to the emergency room and to the doctor (P < 0.001, and a higher number of hospitalizations (P < 0.001. Older individuals had an increased risk of COPD (adjusted odds ratio [ORa] = 1.05; so did “ever” cigarette smokers (ORa = 4.88 and water-pipe smokers (ORa = 2.53.Conclusion: This is the first epidemiological study in Lebanon that determined COPD prevalence and the link with water-pipe smoking.Keywords: COPD, prevalence, water-pipe smoking

  1. "Um vasto prazer, quieto e profundo"

    Directory of Open Access Journals (Sweden)

    Eliane Robert Moraes

    2009-01-01

    Full Text Available A descrição da tortura de um rato, no conto "A causa secreta" de Machado de Assis, pode parecer tímida se comparada às cenas de suplício narradas por Sade. Todavia, uma leitura mais atenta encontrará ali as condições essenciais para a eclosão de uma misteriosa forma de prazer que costuma estar associada à figura do "sádico". Uma tal aproximação surpreende ainda mais quando se constata que o sadismo do protagonista do conto assume contornos bem mais verossímeis do que as inconcebíveis fabulações de crueldade dos devassos do marquês. Este texto parte do confronto entre os dois autores, valendo-se do diálogo entre uma dimensão estética (o realismo e outra ética (o mal, na tentativa de propor uma interpretação do conto machadiano.The description of a mouse being tortured in Machado de Assis's short story "A causa secreta" [English translation: "The Secret Heart"] may seem timid if compared with the scenes of agony narrated by the Marquis De Sade. Nevertheless, a detailed reading will find in this short story essential conditions for the outburst of a mysterious form of pleasure that is usually associated with the image of a "sadist". A closer look might surprise the reader even more with the acknowledgement that the sadism of the protagonist takes on shapes that are more verisimilar than the inconceivable accounts of cruelty of the Marquis's dissolute characters. By means of a dialogue between an aesthetic dimension (realism and an ethic dimension (evil, this essay confronts these two authors in an attempt to propose an interpretation of Machado de Assis's short story.

  2. Soybean (Glycine max) as a versatile biocatalyst for organic synthesis

    African Journals Online (AJOL)

    Luciana

    2012-04-12

    Apr 12, 2012 ... Cetonas Aromáticas Utilizando a Casca da Passiflora como. Biocatalisador. MS Thesis, Edições UFC, Fortaleza, Brazil, 2003. Machado LL, Monte FJQ, de Oliveira MCF, de Mattos MC, Lemos TLG,. Gotor-Fernández V, Gonzalo G, Gotor V (2008). Bioreduction of aromatic aldehydes and ketones by fruits' ...

  3. New species of scytonema agardh (Cyanophyta)

    CSIR Research Space (South Africa)

    Welsh, H

    1963-01-01

    Full Text Available . puhifrar, par: E Rcsgxog. As so pal-at as dos rabae,,os I. -_ 9, fora,n publicadas con, a data do sc?a, as outras corn spSg. ED ITO RES C. CHAGAS A. DE B. MACHADO INSTITUTO DR 1310-FISICA MTJSEU DO DUNDO AVENIDA PASTEUR, N.? 458 DUNDO RIO Pit JANIt...

  4. Ofelia Rodríguez Acosta and the Quest for National Solidarity in Cuba

    Science.gov (United States)

    Ortiz-Loyola, Brenda

    2015-01-01

    By the mid-1920s, the feminist movement was gaining strong support within Cuban society, at the same time that Cubans were growing discontent with the repression and corruption of Gerardo Machado's dictatorial regime. Within this context, women writers like Ofelia Rodríguez Acosta fused the feminist fight for women's rights with a nationalist…

  5. Detection of Threat Materials Using Terahertz Waveguides and Long Pathlength Terahertz Spectroscopy

    Science.gov (United States)

    2015-05-01

    34Temperature dependent characterization of THz vibrations of explosives and related threat materials," Joseph S. Melinger, S. Sree Harsha, N. Laman ...materials,” Joseph S. Melinger, S. Sree Harsha, N. Laman , and D. Grischkowsky, Proc. SPIE 7671, 76710H (2010) Presentations: 1. ”Broadband THz...of crystal structures with poor data,” Acta Crystallogr. B 31(7), 1864–1869 (1975). 10) Joseph S. Melinger, S. Sree Harsha, N. Laman and D

  6. On the Clarification of Concepts: A Reply to Gallistel (2007) and Lau (2007)

    Science.gov (United States)

    Machado, Armando; Silva, Francisco J.

    2007-01-01

    The authors argue that some of C. R. Gallistel's and H. C. Lau's solutions to the problems raised in the article by A. Machado and F. J. Silva are unlikely, logically inconsistent, or at odds with empirical evidence. In particular, Lau seems not to appreciate the necessity of clear and consistent psychological constructs before trying to map these…

  7. ÜRO peakorterile otsitakse naabrit / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-

    2001-01-01

    New Yorki, ÜRO peakorterist lõunasse hakatakse ehitama uut hoonet. Arhitektuurikonkursist on kutsutud osalema: David Childs, Richard Meier ja Peter Eisenmann; Schuman Lichtenstein Claman Efron ja HOK arhitektid; Kohn Pederson Fox, Davis Brody Bond, Toyo Ito ja Rem Koolhaas; Henry Cobb, James Ingo Freed ja Machado & Silvetti Associates; Christian de Portzamparc ja Gary Edward Handel & Associates

  8. Profiles in medical courage: Joseph Goldberger, the sharecropper’s plague, science and prejudice

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2012-06-01

    Full Text Available No abstract available. Article truncated at 150 words. “You must accept the truth from whatever source it comes”. -MaimonidesThe Sharecropper’s PlagueIn the early half of the twentieth century a mysterious disease, “the sharecropper’s plague”, reached epidemic proportions in the Southern US (1. Each state decided whether it would recognize and publicly admit the existence of what was then considered an embarrassment. The total number of new annual cases was estimated as about 75,000 in 1915 and about 100,000 throughout the 1920s (2. The disease had a 40% mortality rate, and many survivors with dementia were confined to mental institutions (3. Patients initially presented with symmetrically reddened skin, similar to that produced by a sunburn or poison oak. Later, the dermatitis turned rough and scaly in one or more locations, such as the hands, the tops of the feet, or the ankles, or in a butterfly-shaped distribution across the nose. Disturbances of the digestive tract and the …

  9. Inpatient management of borderline personality disorder at Helen ...

    African Journals Online (AJOL)

    Inpatient management of borderline personality disorder at Helen Joseph Hospital, Johannesburg. ... South African Journal of Psychiatry ... to the acute inpatient psychiatric assessment unit at the Helen Joseph Hospital, in Johannesburg, over ...

  10. VENOUS THROMBOSIS COMPLICATIONS IN THERMAL TRAUMA. A LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    V. S. Borisov

    2016-01-01

    Full Text Available The article analyzes the currently existing data concerning incidence and timing of venous thrombosis development in burn patients. There is no consensus not only on the incidence of this disease amongst burn patients, but also on methods of diagnosis and prevention. For the first time, we raised an issue of the need for formation of risk groups using the scale of prof. Joseph Caprini (USA applied to patients with thermal injury.

  11. 78 FR 22302 - United States v. United Technologies Corporation and Goodrich Corporation; Public Comments and...

    Science.gov (United States)

    2013-04-15

    ... negotiation of the Proposed Final Judgment. Although Mr. Reusser supervised the Goodrich organization... to persuade Mr. Oak not to do so. B. Joseph C. Jefferis 1. Summary of the Comment Mr. Joseph C...

  12. Compositions and joints of the imaginary to the understanding of digital games that deal with health

    Directory of Open Access Journals (Sweden)

    Lúcia Márcia C. Lemos

    2013-12-01

    Full Text Available This paper aims to verify the theme of the imaginary present in the game "Privates", a Serious Game that has as one of the topic the prevention of Sexually Transmitted Diseases (STDs. For a broader understanding of the imaginary part of the theoretical reflections of Bakhtin, Durand, Haraway, Leão, Maffessoli, Malrieu, Machado da Silva, among others. In the perspective of virtual games, the references are from Huizinga, Murray and Maietti. The semiotic approach of Gramsci assists in the analysis of figuration, aesthetics and narrativity system. With the articulation between different knowledge was that real can rebuild an imaginary part of female body, take possession heroes figures linked to action and adventure, to teach how to build plural solutions in the fight against STD. It is characterized, as well as a new form of themes of science and health communication.

  13. Nódulo umbilical metastático (nódulo da Irmã Maria José: um sinal de alerta para tumoração maligna intra-abdominal - relato de caso Sister Mary Joseph's nodule: a warning sign for intra-abdominal malignant tumors. A case report

    Directory of Open Access Journals (Sweden)

    Homero Soares Fogaça

    2003-07-01

    Full Text Available O nódulo da "Irmã Maria José" é tumor metastático que acomete a cicatriz umbilical e pode ser a primeira evidência de neoplasia intra-abdominal disseminada. Os autores relatam o caso de uma paciente com o nódulo da "Irmã Maria José" no qual o diagnóstico do tumor primário só foi possível por meio dos testes imuno-histoquímicos da lesão biopsiada da pele.The umbilical metastatic tumoral nodule, Sister Mary Joseph's nodule, is a rare clinical sign indicative of disseminated intra-abdominal tumor, and may be the first evidence of malignancy. The authors report a case of a patient with umbilical metastatic nodule in whom the diagnosis of the primary tumor was possible by immunohistochemistry of the lesion biopsy.

  14. Des personnages érigés en narrateurs : les voix over chez Joseph L. Mankiewicz (A Letter to Three Wives, All about Eve et The Barefoot Contessa

    Directory of Open Access Journals (Sweden)

    Alain Boillat

    2011-08-01

    Full Text Available L’auteur analyse dans une perspective narratologique trois films de Joseph L. Mankiewicz réalisés entre 1949 et 1954 (A Letter to Three Wives, All about Eve et The Barefoot Contessa afin d’observer les particularités qui résultent du recours à un ou plusieurs narrateurs (ou narratrices s’exprimant en voix over. L’accent est mis sur les implications de l’organisation énonciative complexe de ces productions cinématographiques en termes de relation du film au spectateur et de représentation des rapports de genre. Ces études de cas permettent de nuancer certains acquis issus du champ des théories de l’énonciation. Dans ces films où les voix over sont proférées par des acteurs qui incarnent par ailleurs un personnage visualisé, certaines interactions sont observables – interprétées notamment comme des relations de pouvoir – entre le statut des narrateurs et le niveau diégétique. La matérialité sonore est prise en compte dans le cas particulier de Letter to Three Wives, où la voix se transforme en bruit. Cet « effet spécial » est l’occasion de discuter un modèle « impersonnel » de l’énonciation filmique qui intègre, tout en tenant compte de la dimension technologique de l’enregistrement sonore, le pouvoir fondamentalement humanisant des manifestations vocales.

  15. Installation Restoration Program Stage 2-1 Remedial Investigation. Beale Air Force Base, Marysville, California. Volume 3. Appendix B - K

    Science.gov (United States)

    1991-03-29

    I0IYOiHPI1 ISenu n!W .46 ,.II I J LIo Yg I 0 lf I IJliGn I r IM,I I.E_ I IVAna di mjdIIi ~ LaIIII j~inc zo- 20 III IT _______ di ~ ’n F-256 / ____CHZN...VJ is the lijit of detecticq fcr ’thit cvicmud. ba~ ern 1flutic-1. irdicates in estisated trice a lh ANAL Y ST :________________ OrRF.OED BY

  16. Remarks of Joseph Marrone

    International Nuclear Information System (INIS)

    Marrone, J.

    1985-01-01

    The author's remarks are directed primarily at proposals that have been made that would substantially tort law with respect to radiation claims in order to ease the ability of claimants to recovery damages from defendants. The change would be based upon what had been assumed to be a ''scientific'' means of measuring the ''probability'' that exposure to ionizing radiation was the case of a cancer in a particular claimant. The remarks are divided into three parts: a summary description of the nuclear insurance pools, including the tort radiation claims filed against the pools; and a brief description of claims against the Federal Government and its contractors; an examination of the elementary principles of tort law, and an outline of the threat that has developed that would transform it into a hybrid social benefits program; and comment on the danger to the integrity of science when it is injected into the legislative process

  17. Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Ghouri YA

    2014-12-01

    Full Text Available Yezaz A Ghouri, David M Richards, Erik F Rahimi, Joseph T Krill, Katherine A Jelinek, Andrew W DuPont The University of Texas Medical School at Houston, Houston, Texas, USA Background: Probiotics are microorganisms that are ingested either in combination or as a single organism in an effort to normalize intestinal microbiota and potentially improve intestinal barrier function. Recent evidence has suggested that inflammatory bowel disease (IBD may result from an inappropriate immunologic response to intestinal bacteria and a disruption in the balance of the gastrointestinal microbiota in genetically susceptible individuals. Prebiotics, synbiotics, and probiotics have all been studied with growing interest as adjuncts to standard therapies for IBD. In general, probiotics have been shown to be well-tolerated with few side effects, making them a potential attractive treatment option in the management of IBD. Aim: To perform a systematic review of randomized controlled trials on the use of probiotics, prebiotics, and synbiotics in IBD. Results: In our systematic review we found 14 studies in patients with Crohn’s disease (CD, 21 studies in patients with ulcerative colitis (UC, and five studies in patients with pouchitis. These were randomized controlled trials using probiotics, prebiotics, and/or synbiotics. In patients with CD, multiple studies comparing probiotics and placebo showed no significant difference in clinical outcomes. Adding a probiotic to conventional treatment improved the overall induction of remission rates among patients with UC. There was also a similar benefit in maintaining remission in UC. Probiotics have also shown some efficacy in the treatment of pouchitis after antibiotic-induced remission. Conclusions: To date, there is insufficient data to recommend probiotics for use in CD. There is evidence to support the use of probiotics for induction and maintenance of remission in UC and pouchitis. Future quality studies are

  18. Coleção particular de Agenor Machado

    Directory of Open Access Journals (Sweden)

    Miriam Lifchtz Moreira Leite

    1977-09-01

    Full Text Available (primeiro parágrafo do artigo A doação desta Coleção Particular feita ao Setor de Documentação Histórica do Departamento de História da Universidade de São Paulo contribui para o acervo do Setor com material diversificado e de grandes potencialidades para estudos de História Contemporânea.  Apesar de uma Coleção Particular sempre trazer a marca de quem reuniu os documentos e conservar um caráter individual muito nítido, esta ultrapassa essa condição pelo fato de se tratar de pessoa de interesses muito generalizados, ultrapassando o quadro freqüentemente restrito a uma vida pessoal e uma vida profissional: Engenheiro da Comissão Geográfica e Geológica do Estado de São Paulo, revela pendores pelo estudo da Geografia, participando das comissões das primeiras revistas e colaborando nas de Engenharia do Colégio Mackenzie. A Coleção revela sua dedicação aos problemas de fronteiras, estradas, água, clima, recursos naturais e saneamento, e as apostilas incluidas revelam a participação nos primeiros cursos da Escola Livre de Sociologia e Política, ampliando, através dos livros, seus conhecimentos de Economia, Política, Estatística e Direito.

  19. FLORBELA ESPANCA E GILKA MACHADO: LILITHS DA MODERNIDADE

    Directory of Open Access Journals (Sweden)

    Rosana Gonçalves

    2012-10-01

    diferença pelo forte apego aos símbolos e pelo respeito à tradição formal aliados a uma mensagem extremamente subjetiva de contestação e indignação com a situação de “malditas” que, assim como Lilith, partilhavam.

  20. Final Environmental Impact Statement for Development of Facilities to Support Basing US Pacific Fleet F/A-18E/F Aircraft on the West Coast of the United States, Volume 1.

    Science.gov (United States)

    1998-05-01

    California, pp. 592-609. Robert F. Heizer , Volume Editor. William C. Sturtevant, General Editor. Smithsonian Institution, Washington, DC. Machado, Dee...American Indians, Vol. 8. California, pp. 448-461. Robert F. Heizer , Volume Editor. William C. Sturtevant, General Editor. Smithsonian Institution... rendered in quintuplicate to: Commanding Officer " Naval Air Station =Lemoore, California ^l" Payments will be^made by: Commanding Officer Navy

  1. Pedagogical and Social Philosophy in Zambrano’s Family. Between Krausism and Zambranism

    Directory of Open Access Journals (Sweden)

    José Barrientos Rastrojo

    2014-11-01

    Antonio Machado, a close friend of Blas Zambrano, and Manuel Azaña, the last president of the Second Spanish Republic. Our work aims to collect lessons from Zambrano´s (father and daughter speeches to learn how to form contemporary human beings. Furthermore, we will recover pedagogical resources buried by time and by some hidden interests.

  2. Ocorrência de moscas ectoparasitas (Diptera, Streblidae e Nycteribiidae de morcegos (Mammalia, Chiroptera no cerrado de Brasília, Distrito Federal, Brasil Records of batflies (Diptera, Streblidae and Nycteribiidae on bats (Mammalia, Chiroptera from the cerrado of Brasília, Distrito Federal, Brazil

    Directory of Open Access Journals (Sweden)

    Gustavo Graciolli

    2002-07-01

    Full Text Available Two species of Basilia Miranda Ribeiro, 1903 (Nycteribiidae and eigth species of Streblidae were collected from Brasília. Basilia anceps Guimarães & D' Andretta, 1956; B. hughscotti Guimarães & D' Andretta, 1956; Megistopoda aranea (Coquillet, 1899; M. proxima (Séguy, 1926 and Neotrichobius delicatus (Machado-Allison, 1966 are collected for the first time at the Federal District.

  3. Ghana Journal of Geography - Vol 7, No 2 (2015)

    African Journals Online (AJOL)

    The life struggles and successes of the migrant construction worker in Accra, Ghana · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Joseph A. Yaro, Mariama Awumbila, Joseph Kofi Teye, 113-131 ...

  4. Geochronologic (K-Ar/Fission track) east-west profile of the Rio Grande do Sul shield

    International Nuclear Information System (INIS)

    Poupeau, G.; Baitelli, R.; Berbert, M.

    1985-01-01

    An E-W sampling was executed from Pelotas to Dom Pedrito, Rio Grande do Sul state, for K-Ar and Fission-track (FT) dating. Within the Dom Feliciano Orogenic Belt, from pelotas to Pinheiro Machado, K-Ar in biotites increase from 530m.y. to 655 m.y., with a discontinuity at the level of the approx.10Km wide Cangacu cataclastic Zone. In two samples from the Rio de La Plata Craton, at the western end of our profile, hornblendes present K-Ar ages of 1.555m.y. and 1.594m.y. FT ages in apatites record cooling of these minerals below 120 + - 20 0 C. From Pelotas to Pinheiro Machado, four sample present concordant ages at 270 + - 10m.y., whiel western most sample records a later event at 216 m.y. From the structure of plateau-ages it is suggested that the events dated are two positive tectonic pulses. Examination of the sedimentary of the Parana Basin confirms this interpretation. We therefore dated isotopically, for the firts time in Rio Grande do Sul basement, the ages of the two tectonic pulses wich affected the sedimentation in the Parana Basin. (Author) [pt

  5. Geochronologic (K-Ar/Fission Track) east-west profile of the Rio Grande do Sul shield

    International Nuclear Information System (INIS)

    Poupeau, G.; Baitelli, R.; Berbert, M.; Kawashita, K.

    1985-01-01

    An E-W sampling was executed from Pelotas to Dom Pedrito, Rio Grande do Sul State, for K-Ar and fission-track (FT) dating. Within the Dom Feliciano Orogenic Belt, from Pelotas to Pinheiro Machado, K-Ar in biotites increase from 530 m.y. to 655 m.y., with a discontinuity at the level of the 10 km wide Cangacu cataclastic Zone. In two samples from the Rio de La Plata Craton, at the Western end of our profile, hornblendes present K-Ar ages of 1.555 m.y and 1.594 m.y. FT ages in apatites record the cooling of these minerals below 120+- 20 0 C. From Pelotas to Pinheiro Machado, four samples present concordant ages at 270+ -10 m.y., while the western sample records a later event at 216 m.y. From the structure of plateau-ages it is suggested that the events dated are two positive tectonic pulses. Examination of the sedimentary of the Parana Basin confirms this interpretation. We therefore dated isotopically, for the first time in Rio Grande do Sul basement, the ages of the two tectonic pulses which affected the sedimentation in the Parana Basin. (Author) [pt

  6. Revisão da subfamília Atactorhynchinae Petrotschenko, 1956 (Acanthocephala - Neoechinorhynchidae A review of Atactorhynchinae Petrotschenko, 1956 (Acanthocephala, Neoechinorhynchidae

    Directory of Open Access Journals (Sweden)

    Dely Noronha

    1973-01-01

    Full Text Available No presente trabalho é feita a revisão da subfamília Atactorhynchinae Petrostschenko, 1956. Para o gênero Floridosentis Ward, 1953, o estudo é baseado em exemplares do material tipo, além de outros encontrados parasitnando três peixes do gênero Mugil (Parati, provenientes de Cabo Frio, Rio de Janeiro. Quanto ao gênero Atactorhynchus Chandler, 1935, o nosso estudo foi baseado na descrição original de Chandler e do trabalho de Golvan sobre a classe dos Eoacanthocephala (Van Cleave, 1936.In this paper, the authors revise the sub-family Atactorhynchinae Petrotschenko, 1956, after studying types of Floridosentis mugilis (Machado Filho, 1951 and material recovered from intestine of Mugil sp. from Cabo Frio, Estado do Rio de Janeiro, Brasil. They confirm what was suggested by Bullock, 1962, about a new combination for the type species of Floridosentis Ward, 1953. For this reason, they make F. elongatus, synonym of F. mugilis Machado Filho, 1951. Besides they also enlarge the subfamily diagnosis and add a table showing the maind differences between the two genera under Atactorhynchinae Petrotschenko, 1956.

  7. O VALOR HIPOTEXTUAL DO CONTO “MISSA DO GALO”

    Directory of Open Access Journals (Sweden)

    Tiago Pellizzaro

    2008-11-01

    Full Text Available Este estudo investiga aspectos que levam à transformação do conto “Missa do galo” em palimpsesto. Quase oito décadas depois de sua publicação, a obra Missa do galo: variações sobre o mesmo tema é lançada, apresentando seis propostas de aproximação do texto original de Machado de Assis. Noções teóricas acerca da intertextualidade, bem como conceitos formulados pela Estética da Recepção embasam o desenvolvimento desta análise. A principal razão para entender por que a determinadas criações literárias é concedido o estatuto de hipotexto se deve ao fato de que a literatura desempenha uma função social, que se corporifica através do relacionamento prolífico do leitor com o texto. As obras são caracterizadas por indeterminações textuais. Machado intencionalmente as acentua, como se verifica em “Missa do galo”. Essa prática estimula a produção de textos que, de certo modo, procuram dar prosseguimento ao enredo delineado pelo autor carioca.

  8. Revisited Alcibiades: a portrait and an interpretation

    Directory of Open Access Journals (Sweden)

    Eunice Terezinha Piazza Gai

    2008-12-01

    Full Text Available O texto apresenta uma interpretação do conto “Uma visita de Alcibíades”, de Machado de Assis. Considerando que a biografia de Alcibíades, elaborada por Plutarco, é a fonte de inspiração para o autor brasileiro, busca estabelecer as relações entre os textos e a visão do mundo que apresentam. Os dois autores são classificados como retratistas no contexto da cultura ocidental, por isso, o estudo contempla alguns aspectos relevantes que caracterizam essa atividade. Procura mostrar que o conto constitui um interessante retrato do grego Alcibíades e é representativo de uma das grandes tendências da estética machadiana que é o estudo de caracteres. Constata outrossim que o texto de Machado constitui uma interpretação daquele de Plutarco que, por sua vez, também é uma interpretação. E o tema central de ambos os retratos é a sedução exercida pela personagem, tendo em vista as diferentes implicações que semelhante caráter possui do ponto de vista ético.

  9. Search for the Neutrino Less Double Beta Decay

    Energy Technology Data Exchange (ETDEWEB)

    Efremenko, Yuri [Univ. of Tennessee, Knoxville, TN (United States). Dept. of Physics and Astronomy

    2016-07-11

    During the past few years our understanding of neutrino properties has reached a new level, with experiments such as Super-K, SNO, KamLAND, and others obtaining exciting results. Major questions such as “Do neutrinos have mass?” and “Do neutrinos oscillate?” now have positive answers. However, an extensive program of neutrino research remains. Undoubtedly, the most important of these is the question pointed out by the National Research Council in its February 2002 report “Connecting Quarks with the Cosmos”, specifically: What are the masses of neutrinos and how have they shaped the evolution of the Universe? The MAJORANA collaboration has proposed to build the world’s most sensitive one-ton scale experiment to search for neutrino less double beta decay to answer this question. In its initial stage, the collaboration is building a prototype MAJORANA DEMONSTRATOR (MJD) experiment consisting of detectors made out of enriched Ge76 with a total sensitive mass of ~30 kg. This will accomplish two goals. First, it will test not yet confirmed claim for observation of neutrino-less double beta decay. Second, it will establish that the selected technology is capable of extension to a one-ton experiment with sufficient sensitivity to measure neutrino mass mββ down to 10 meV. To achieve the last goal, collaboration must demonstrate that a background level of 1 count per year per 4 keV per ton of detector is achievable. The University of Tennessee (UT) neutrino group has made a major commitment to the MJD. P.I. accepted the responsibility for one of the major tasks of the experiment, “Materials and Assay Task” which is crucial to the achievement of low background levels required for the experiment. In addition, the UT group is committed to construct, commission, and operate the MJD active veto system. Those activities were supported by NP-DOE via program funding for “Search for the Neutrino Less Double Beta Decay” at the University

  10. Protein leverage effects of beef protein on energy intake in humans.

    Science.gov (United States)

    Martens, Eveline A; Tan, Sze-Yen; Dunlop, Mandy V; Mattes, Richard D; Westerterp-Plantenga, Margriet S

    2014-06-01

    The protein leverage hypothesis requires specific evidence that protein intake is regulated more strongly than energy intake. The objective was to determine ad libitum energy intake, body weight changes, appetite profile, and nitrogen balance in response to 3 diets with different protein-to-carbohydrate + fat ratios over 12 consecutive days, with beef as a source of protein. A 3-arm, 12-d randomized crossover study was performed in 30 men and 28 women [mean ± SD age: 33 ± 16 y; body mass index (in kg/m²): 24.4 ± 4.0] with the use of diets containing 5%, 15%, and 30% of energy (En%) from protein, predominantly from beef. Energy intake was significantly lower in the 30En%-protein condition (8.73 ± 1.93 MJ/d) than in the 5En%-protein (9.48 ± 1.67 MJ/d) and 15En%-protein (9.30 ± 1.62 MJ/d) conditions (P = 0.001), stemming largely from lower energy intake during meals (P = 0.001). Hunger (P = 0.001) and desire to eat (P = 0.001) ratings were higher and fullness ratings were lower (P = 0.001) in the 5En%-protein condition than in the 15En%-protein and 30En%-protein conditions. Nitrogen excretion was lower in the 5En%-protein condition (4.7 ± 1.5 g/24 h; P = 0.001) and was higher in the 30En%-protein condition (15.3 ± 8.7 g/24 h; P = 0.001) compared with the 15En%-protein condition (10.0 ± 5.2 g/24 h). Nitrogen balance was maintained in the 5En%-protein condition and was positive in the 15En%- and 30En%-protein conditions (P = 0.001). Complete protein leverage did not occur because subjects did not consume to a common protein amount at the expense of energy balance. Individuals did underconsume relative to energy requirements from high-protein diets. The lack of support for protein leverage effects on a low-protein diet may stem from the fact that protein intake was sufficient to maintain nitrogen balance over the 12-d trial. © 2014 American Society for Nutrition.

  11. Kundetilpasset masseproduktion

    DEFF Research Database (Denmark)

    Bukh, Per Nikolaj

    2010-01-01

    Anmeldelse af Do you want to keep your customers forever, B. Joseph Pine II, Don Peppers & Martha Rogers, Harvard Business Press.......Anmeldelse af Do you want to keep your customers forever, B. Joseph Pine II, Don Peppers & Martha Rogers, Harvard Business Press....

  12. 76 FR 45249 - PJM Interconnection, L.L.C.; Supplemental Notice of Staff Technical Conference

    Science.gov (United States)

    2011-07-28

    ... and Government Relations, Comverge, Inc. Bruce Campbell, Director of Regulatory Affairs, Demand...] Dr. Joseph E. Bowring, Market Monitor, Independent Market Monitor for PJM [rtarr9] Frederick (``Stu... Flaherty Beliveau & Pachios LLP representing EnerNOC, Inc. [rtarr9] Dr. Joseph E. Bowring, Market Monitor...

  13. 76 FR 25763 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-05-05

    ... with the vision deficiency: Christopher Kahl, Althea Renita Dowell, Steven DuBois, Steve Campbell... Pulido, Oliver Murphy, Jerome Smalls, Alan Jenkins, Ryan Forsythe, Terry L. Randoll, Edward Joseph... for an exemption. Thomas L. Newingham, Joseph Barlow. The following 2 applicants do not have...

  14. An Ensemble of Atomic Fountains

    Science.gov (United States)

    2012-05-01

    1.5 -1.0 -0.5 0.0 0.5 1.0 1.5 ph as e (n s) 56000559005580055700 MJD 8 10-16 2 4 6 8 10-15 2 4 ov er la pp in g Al la n de vi at io n 104... Metrologia 49, 49-56 (2012). [3] N. Ashby et al., Phys. Rev. Lett. 98, 070802 (2007). [4] S. J. Ferrell, et al., Phys. Rev. A 76, 062104 (2007). [5] T. M

  15. Palju kära, aga mitte kuigi palju villa = Talkin' loud and saying not that much / Mika Hannula

    Index Scriptorium Estoniae

    Hannula, Mika, 1967-

    2015-01-01

    Kunstikriitik analüüsib nüüdisaegse kunsti poliitiliste aktide õnnestumisi ja ebaõnnestumisi Kiasma rahvusvahelisel rühmanäitusel "Demonstrating minds - disagreements in contemporary art" (Meele avaldused - erimeelsused nüüdisaegses kunstis) eksponeeritud tööde näitel. Vaatluse all on Cristina Lucase, Tanja Boukali, Jonathan Meese, Cinthia Marselle'i & Tiago Mata Machado ning Kader Attia teosed

  16. Archean and proterozoic continental crust in South America: Main building events

    International Nuclear Information System (INIS)

    Fuck, R.A; Brito Neves, B.B; Pimentel, M.M

    2001-01-01

    Available geochronological data reveal that the first building blocks of the South American continental crust were set up in the early Paleoarchean, ca. 3.4-3.5 Ga ago, although the presence of components as old as 3.7 Ga is indicated by Nd TDM model ages. The oldest rocks so far recognized are exposed in northeast Brazil and Uruguay. In the Sao Jose do Campestre block, Rio Grande do Norte, 3.45 Ga old tonalite, migmatized and intruded by granitoids between 3.3 and 3.0 Ga, is part of the basement to the Borborema Province (Dantas et al. 1998). In Bahia 3.42 Ga old tonalitic grey gneisses of Sete Voltas, Boa Vista, and Mairi form the basement of the Gaviao block, within the core of the Sao Francisco Craton (Nutman and Cordani, 1993, Martin et al., 1997). The Paleoarchean TTG suites as well as greenstone remnants of unknown age were involved in crust accretion events between 3.1 and 3.3 Ga ago (Teixeira et al. 2000 and references therein), which are also recorded in Campo Belo and Uaua (Teixeira et al., 1998, Oliveira et al., 1999), as attested by TTG intrusions and the ca. 3.1 Ga Pium-hi greenstone belt of W Minas Gerais (Machado and Schrank 1989). Microcontinents then formed were involved in deformation, metamorphism, and migmatization around 2.8-3.0 Ga ago, probably during amalgamation events. Widespread granite-greenstone associations in the Quadrilatero Ferrifero and other areas represent new crust built during the very important Neoarchean Rio das Velhas cycle, ca. 2.7-2.8 Ga ago (Machado and Carneiro 1992, Machado et al. 1992). Layered mafic-ultramafic and granite intrusions ca. 2.5-2.7 Ga old are recorded all over the Sao Francisco Craton, including the high-grade terrain of southern Bahia, formed during the late Archean Jequie Cycle (Teixeira et al. 2000 and references therein). Similar intrusions are recorded in many basement areas within Neoproterozoic fold belts (au)

  17. Carbon and nitrogen isotopic composition of suspended particulate organic matter in Zuari Estuary, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Bardhan, P.; Karapurkar, S.G.; Shenoy, D.M.; Kurian, S.; Sarkar, A.; Maya, M.V.; Naik, H.; Varik, S.; Naqvi, S.W.A.

    participates in riverine delivery of bioavailable nitrogen to coastal zones. Global Biogeochemical Cycles 12(4), 573-579. 30. Naqvi, S. W. A., Jayakumar, D. A., Narvekar, P. V., Naik, H., Sarma, V. V. S. S., D'souza, W., Joseph,S. George, M. D. (2000...

  18. 76 FR 50436 - Kentucky Regulatory Program

    Science.gov (United States)

    2011-08-15

    ... instructions; or Mail/Hand Delivery/Courier: Joseph L. Blackburn, Field Office Director, Lexington Field Office... Office. Joseph L. Blackburn, Field Office Director, Lexington Field Office, Office of Surface Mining Reclamation and Enforcement, 2675 Regency Road, Lexington, Kentucky 40503, (859) 260-3900. Carl E. Campbell...

  19. 76 FR 15995 - Notice of Public Meeting: Northeast California Resource Advisory Council Subcommittee

    Science.gov (United States)

    2011-03-22

    ... District manager, (530) 224-2160; or Joseph J. Fontana, BLM public affairs officer, (530) 252-5332... as provided above. Dated: June 14, 2010. Joseph J. Fontana, Public Affairs Officer. [FR Doc. 2011... Public Meeting: Northeast California Resource Advisory Council Subcommittee AGENCY: Bureau of Land...

  20. [Is oral rehydration with nasogastric tube more efficient than rehydration with spoon? Preliminary study in children with non-severe dehydration in Joseph-Raseta-Befelatanana Hospital, Madagascar].

    Science.gov (United States)

    Ravelomanana, T; Rabeatoandro, S; Randrianaivo, N; Ratsimbazafy, A; Raobijaona, H; Barennes, H

    2010-05-01

    Since its recommendation by WHO, Oral Rehydration Solutions (ORS) contributed in reducing the rate of mortality due to acute gastroenteritis. In Madagascar, the rate of lethality imputed to gastroenteritis is about 3%. Rehydration can be performed either by using spoons which reliability is unsure because of parents' potential inobservance and child's refusal, or by nasogastric tube. The nasogastric tube may resolve these obstacles at the hospital. We realized a preliminary study to evaluate the efficacy and the safety of nasogastric tube and spoon administration of the ORS in rehydration of child with moderate post-gastroenteritis dehydration. This is an open comparative study realized in the Pediatric Unit at the Joseph-Raseta-Befelatanana Hospital from the 21 January to 21 May 2008. Main outcomes was the proportion of rehydrated children at 4 hours, other were: failure at 8 hours, duration and volume of SRO, side effects. Fifty-three children from 4-month to 4-year old among 1306 patients were recruited and forty-seven patients were included. Nine patients failed (4 children received ORS by spoon and 5 children by nasogastric tube). The use of spoon was more effective: 62.5% of the patients were rehydrated at the fourth hour versus 39.3% in nasogastric tube group (P = 0.04). Making debit constant presents difficulties in rehydration with nasogastric tube (44.4 %). Tolerance of nasogastric tube is generally good but 16.7% children get out their tube during this study. No ORS' inhalation was observed with both routes. No false passage or tube or ORS rejection was recorded in both techniques. This study shows that using spoon to rehydrate is more effective for the rehydration of moderate dehydration. The use of nasogastric tube needs more surveillance.

  1. Cooking with Fire: The Mutagenicity- and PAH-Emission ...

    Science.gov (United States)

    Emissions from solid fuels used for cooking cause ~4 million premature deaths per year. Advanced solid-fuel cookstoves are a potential solution, but they should be assessed by appropriate performance indicators, including biological effects. We evaluated two categories of solid-fuel cookstoves for 8 pollutant- and 4 mutagenicity-emission factors, correlated the mutagenicity-emission factors, and compared them to those of other combustion emissions. We burned red oak in a 3-stone fire (TSF), a natural-draft stove (NDS), and a forced-draft stove (FDS); we combusted propane as a liquified petroleum gas control fuel. We determined emission factors based on useful energy (megajoules delivered, MJd) for carbon monoxide, nitrogen oxides (NOx), black carbon, methane, total hydrocarbons, 32 polycyclic aromatic hydrocarbons, PM2.5, levoglucosan (a wood-smoke marker), and mutagenicity in Salmonella. Other than NOx the emission factors per MJd correlated highly among each other (r2 ≥ 0.92); NOx correlated 0.58-0.76 with the other emission factors. Excluding NOx, the NDS and FDS reduced the emission factors on average 68 and 92%, respectively, relative to the TSF. Nonetheless, the mutagenicity-emission factor based on fuel energy used (MJthermal) for the most efficient stove (FDS) was intermediate to that of a large diesel bus engine and a small diesel generator. Both mutagenicity- and pollutant-emission factors may be informative for characterizing cookstove

  2. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 115; Issue 4. Large Time Behaviour of Solutions of a System of Generalized Burgers Equation. K T Joseph ... Author Affiliations. K T Joseph1. School of Mathematics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, India ...

  3. Closing the Convoy Security Gap

    Science.gov (United States)

    2013-04-11

    January 18, 2013. Heiser Jr., LtGen Joseph M. Vietnam Studies: Logistic Support. Washington, DC: Department of the Army, 1991. Killbane, Richard E...School Library, 1968. http://www.transchool.eustis.army.mil/lic/documents/pdf/bellino.pdf 13 LtGen Joseph M. Heiser Jr., Vietnam Studies: Logistic

  4. Logistics in Security Force Assistance: Sustainable Partner Development

    Science.gov (United States)

    2014-05-22

    93Khuyen, 446. 94See Lieutenant General Joseph M. Heiser , Jr., CMH Pub 90-15, Logistic Support (Washington, DC: Center of Military History, U.S. Army...Government Printing Office, 2009. Heiser , Joseph M. Jr., Lieutenant General. CMH Pub 90-15, Logistic Support. Washington, DC: Center of Military

  5. 77 FR 26786 - Notice of Public Meeting: Northeast California Resource Advisory Council

    Science.gov (United States)

    2012-05-07

    ... District manager, (530) 224-2160; or Joseph J. Fontana, BLM public affairs officer, (530) 252-5332..., 2012. Joseph J. Fontana, Public Affairs Officer. [FR Doc. 2012-10888 Filed 5-4-12; 8:45 am] BILLING... Public Meeting: Northeast California Resource Advisory Council AGENCY: Bureau of Land Management...

  6. 77 FR 67664 - Notice of Public Meeting Cancellation: Northwest California Resource Advisory Council

    Science.gov (United States)

    2012-11-13

    ..., BLM Northern California District manager, (530) 221-1743; or Joseph J. Fontana, public affairs officer..., 2012. Joseph J. Fontana, Public Affairs Officer. [FR Doc. 2012-27523 Filed 11-9-12; 8:45 am] BILLING... Public Meeting Cancellation: Northwest California Resource Advisory Council AGENCY: Bureau of Land...

  7. 76 FR 44355 - Notice of Public Meeting Cancellation: Northwest California Resource Advisory Council

    Science.gov (United States)

    2011-07-25

    ... Northern California District manager, (530) 221-1743; or Joseph J. Fontana, public affairs officer, (530..., 2011. Joseph J. Fontana, Public Affairs Officer. [FR Doc. 2011-18774 Filed 7-22-11; 8:45 am] BILLING... Public Meeting Cancellation: Northwest California Resource Advisory Council AGENCY: Bureau of Land...

  8. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Joseph John Thomson. Articles written in Resonance – Journal of Science Education. Volume 2 Issue 12 December 1997 pp 92-106 Classics. Royal Institution of Great Britain - Weekly Evening Meeting · Joseph John Thomson · More Details Fulltext PDF ...

  9. Jesus - Kind van God, Vaderloos in Galilea

    Directory of Open Access Journals (Sweden)

    A.G. van Aarde

    2001-08-01

    Full Text Available This article consists of four sections. Firstly, it reflects on the public debate regarding Jesus' alleged illegitimacy. The article argues that illegitimacy here refers to fatherlessness. Secondly, Joseph is focused on. According to New Testament writings of the latter part of the first century, Joseph is either Jesus' biological father (John's gospel or the person who adopted him as son (the gospels of Matthew and Luke. Thirdly, Joseph as a legendary literary model is discussed (in the Old Testament, intertestamentary literature, the New Testament, writings of the Church Fathers and the dogtrines of the Orthodox Church. Fourthly, the articles sketches a picture of a fatherless Jesus based on evidence from the earliest intracanonical writings (the Sayings Gospel Q, traditions in the Gospel of Thomas, Paul's letters and the Gospel of Mark. Joseph does not appear in these writings. The article concludes with a reflection on the relevance of fatherlessness for today.

  10. Moving the Agenda on Noncommunicable Diseases: Policy Implications of Mobile Phone Surveys in Low and Middle-Income Countries.

    Science.gov (United States)

    Pariyo, George W; Wosu, Adaeze C; Gibson, Dustin G; Labrique, Alain B; Ali, Joseph; Hyder, Adnan A

    2017-05-05

    The growing burden of noncommunicable diseases (NCDs), for example, cardiovascular diseases and chronic respiratory diseases, in low- and middle-income countries (LMICs) presents special challenges for policy makers, due to resource constraints and lack of timely data for decision-making. Concurrently, the increasing ubiquity of mobile phones in LMICs presents possibilities for rapid collection of population-based data to inform the policy process. The objective of this paper is to highlight potential benefits of mobile phone surveys (MPS) for developing, implementing, and evaluating NCD prevention and control policies. To achieve this aim, we first provide a brief overview of major global commitments to NCD prevention and control, and subsequently explore how countries can translate these commitments into policy action at the national level. Using the policy cycle as our frame of reference, we highlight potential benefits of MPS which include (1) potential cost-effectiveness of using MPS to inform NCD policy actions compared with using traditional household surveys; (2) timeliness of assessments to feed into policy and planning cycles; (3) tracking progress of interventions, hence assessment of reach, coverage, and distribution; (4) better targeting of interventions, for example, to high-risk groups; (5) timely course correction for suboptimal or non-effective interventions; (6) assessing fairness in financial contribution and financial risk protection for those affected by NCDs in the spirit of universal health coverage (UHC); and (7) monitoring progress in reducing catastrophic medical expenditure due to chronic health conditions in general, and NCDs in particular. We conclude that MPS have potential to become a powerful data collection tool to inform policies that address public health challenges such as NCDs. Additional forthcoming assessments of MPS in LMICs will inform opportunities to maximize this technology. ©George W Pariyo, Adaeze C Wosu, Dustin G

  11. 77 FR 66084 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2012-11-01

    ... BOUCHARD RAYMOND JOSEPH BOULLE II JEAN-RAYMOND BROMLEY MARGARET ANNE BROWNE CARLA EVELYN BRUCE JAMES TODD... CAMINOS MICHELE CLARE CAMPBELL JESSICA ANNE CHANG WAYNE WEN TIEN CHAN-PALAY VICTORIA LYE-HUA CHEN HOPE MI... RICHARD JOSEPH ARTHUR FUKUDA MEGUMI GAEHWILER YANNIK PETER GEIGER DANIEL CHRISTIAN GEIGER MICHAEL MATTHIAS...

  12. 76 FR 30965 - Notice of Public Meeting: Northwest California Resource Advisory Council

    Science.gov (United States)

    2011-05-27

    ... California District manager, (530) 221-1743; or Joseph J. Fontana, public affairs officer, (530) 252-5332.... Joseph J. Fontana, Public Affairs Officer. [FR Doc. 2011-13233 Filed 5-26-11; 8:45 am] BILLING CODE 4310... Public Meeting: Northwest California Resource Advisory Council AGENCY: Bureau of Land Management...

  13. Computerized gait analysis in Legg Calvé Perthes disease--analysis of the frontal plane.

    Science.gov (United States)

    Westhoff, Bettina; Petermann, Andrea; Hirsch, Mark A; Willers, Reinhart; Krauspe, Rüdiger

    2006-10-01

    Current follow-up and outcome studies of Legg Calvé Perthes disease (LCPD) are based on subjective measures of function, clinical parameters and radiological changes [Herring JA, Kim HT, Browne RH. Legg-Calvé-Perthes disease. Part II: prospective multicenter study of the effect of treatment on outcome. J Bone Joint Surg 2004;86A:2121-34; Aksoy MC, Cankus MC, Alanay A, Yazici M, Caglar O, Alpaslan AM. Radiological outcome of proximal femoral varus osteotomy for the treatment of lateral pillar group-C. J Pediatr Orthop 2005;14 B:88-91; Kitakoji T, Hattori T, Kitoh H, Katho M, Ishiguro N. Which is a better method for Perthes' disease: femoral varus or Salter osteotomy? Clin Orthop 2005;430:163-170; Joseph B, Rao N, Mulpuri K, Varghese G, Nair S. How does femoral varus osteotomy alter the natural evolution of Perthes' disease. J Pediatr Orthop 2005;14B:10-5; Ishida A, Kuwajima SS, Laredo FJ, Milani C. Salter innominate osteotomy in the treatment of severe Legg-Calvé-Perthes disease: clinical and radiographic results in 32 patients (37 hips) at skeletal maturity. J Pediatr Orthop 2004;24:257-64.]. The objective of this study was to evaluate the frontal plane kinematics and the effect on hip joint loading on the affected side in children with a radiographic diagnosis of LCPD. Computerized, three-dimensional gait analysis was performed in 33 individuals aged > or =5 years (mean 8.0+/-2 years) with unilateral LCPD and no history of previous surgery to the hip or any disorder leading to gait abnormality. Frontal plane kinematics and kinetics were compared to a group of healthy children (n=30, mean age 8.1+/-1.2 years). Hip joint loading was estimated as a function of the hip abductor moment. Subjects with LCPD demonstrated two distinct frontal plane gait patterns, both deviating from normal. Type 1 (n=3) was characterized by a pelvic drop of the swinging limb, a trunk lean in relation to the pelvis towards the stance limb and hip adduction during stance phase and

  14. A doença de Chagas no Paraná Chagas disease in the state of Paraná

    Directory of Open Access Journals (Sweden)

    H. C. de Souza-Araujo

    1954-06-01

    Full Text Available In recent speech in Curitiba (May 22nd, 1954, Dr. Mario Pinotti, Director, Serviço Nacional da Malaria, informed that his personnel started on February, 1953, a survey upon chagas Disease in 23 counties of the State of Paraná, South Brazil. out of 895 places surveyed, 678, or 75.7%, were infected by Triatoma infestans klug 1834 and in 234 out of those 678, or 34.5%, this vector was infected by Trypanosoma cruzi. The general natural infection of the insects examined reached 18.86%. The serological survey (Machado-Guerreiro test was positive in 10.7% of the persons examined in jacarezinho and in 28.3% of those living in Bôa Vista. These data suggested the author to actualise the subject. During his control of severe outbreack of malaria in the North part of Paraná, from march to June 1917 he worked in 8 counties. March 1917 he photographed in Boa Vista four girls, severe cases of chronic malaria, two of which showed bi-palpebral oedema, later on considered by Dr. Pinho Simões (1943 as Romanã syndrome (created in 1935 and Prof. Salvador Mazza (1946 classified as typical cases of Chagas' Disease. now, being elapsed 36 years, the National Service of Malaria confirmed the discovery. The region surveyed was populated, in the beginning of this century, by immigrants from the State of Minas Gerais, from where the author believes that were imported the disease and its vectors. In April 1917 the A. discovered that the old town Jatahy was a big focus of Triatoma megista (now Panstrongylus megistus0. All its 43 houses were strongly infested by such hematophagus and amongst the 200 inhabitants seen many were suspicious cases of chronic cases of Chagas's Disease. In the Indians town (three tribes of S. Pedro D' Alcantara, situated in front of Jatahy, in the left side of the river Tibagy, there were no Triatomas nor suspicious cases of trypanosomiasis. In 1919 the author started the control of the endemics by destroying the foci of Triatomas and reforming

  15. The other Dr Hooker: William Dawson Hooker (1816-40).

    Science.gov (United States)

    Lambert, Harold

    2011-11-01

    William Hooker and his son Joseph were famous as botanists and as the creators of the Royal Botanic Gardens in Kew. Joseph was famous also as the friend and mentor of Charles Darwin. But there was another brother, a little older than Joseph, also a doctor and naturalist. He went to Jamaica in the interests of his health and soon died there of yellow fever. His life was short and tragic with a medical conundrum at its end but its story also illustrates many of the beliefs and concerns that preoccupied doctors in this early Victorian era. It also illustrates the close relationship between medicine and botany that prevailed then.

  16. Shakespeare in the Head for Health: A Reality Orientation Option for Alzheimer’s Worriers

    OpenAIRE

    Robert Oliphant

    2009-01-01

    By way of bona fides: As with many Americans, my own extended family has over the years given me plenty of direct contact with senile dementia, the general label for Alzheimer’s disease. In addition, a longish stay in a VA hospital (I’m a WWII vet) brought me into contact with the “reality orientation” anti-Alzheimer’s program developed some years back by Dr. Joseph Folsom, Dr. Arthur Cherkin, and others. On the basis of this experience I subsequently wrote a fictionalized case study about...

  17. 75 FR 22175 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-04-27

    .... Phillips, Joseph A. Ragan, Mark C. Reineke, David J. Schie, David M. Sims, Roland D. Spaniol, Kevin Stein... conditions: James H. Bailey, Johnny J. Campbell, Malcolm J. Celestine, Dale G. Darling, Keith E. Fimon.... Georgeff, Joseph Revis, Jr., Lawrence C. Smoak, III, David C. Watson, Paula L. Wharton. One applicant...

  18. Combat Airmen: Examining USAF Expeditionary Skills Training

    Science.gov (United States)

    2016-02-16

    Andrew M. Rose, Paul H. Radtke , Harris H. Shettel, and Joseph D. Hagman, User’s Manual for Predicting Military Task Retention: Volume I, American...2015). Rose, Andrew M., Paul H. Radtke , Harris H. Shettel, and Joseph D. Hagman. "User’s Manual for Predicting Military Task Retention: Volume I

  19. The Great American Divide: The Military-Civilian Gap

    Science.gov (United States)

    2012-03-14

    Steven A. Bank, Kirk J. Stark, and Joseph J. Thorndike provide a historical account of America’s war-time fiscal policies for the major American wars...accessed January 16, 2012). 63 Steven A. Bank, Kirk J. Stark, Joseph J. Thorndike , War and Taxes (Washington, DC: The Urban Institute Press, 2008

  20. Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom

    Directory of Open Access Journals (Sweden)

    Iwagami M

    2018-04-01

    Full Text Available Masao Iwagami,1 Kathryn E Mansfield,1 Joseph F Hayes,2 Kate Walters,3 David PJ Osborn,2,4 Liam Smeeth,1 Dorothea Nitsch,1 Laurie A Tomlinson1 1Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK; 2Division of Psychiatry, University College London, London, UK; 3Department of Primary Care and Population Health, University College London, London, UK; 4Camden and Islington NHS Foundation Trust, London, UK Objective: We investigated the burden of chronic kidney disease (CKD among patients with severe mental illness (SMI. Methods: We identified patients with SMI among all those aged 25–74 registered in the UK Clinical Practice Research Datalink as on March 31, 2014. We compared the prevalence of CKD (two measurements of estimated glomerular filtration rate <60 mL/min/1.73 m2 for ≥3 months and renal replacement therapy between patients with and without SMI. For patients with and without a history of lithium prescription separately, we used logistic regression to examine the association between SMI and CKD, adjusting for demographics, lifestyle characteristics, and known CKD risk factors. Results: The CKD prevalence was 14.6% among patients with SMI and a history of lithium prescription (n = 4,295, 3.3% among patients with SMI and no history of lithium prescription (n = 24,101, and 2.1% among patients without SMI (n = 2,387,988; P < 0.001. The prevalence of renal replacement therapy was 0.23%, 0.15%, and 0.11%, respectively (P = 0.012. Compared to patients without SMI, the fully adjusted odds ratio for CKD was 6.49 (95% CI 5.84–7.21 for patients with SMI and a history of lithium prescription and 1.45 (95% CI 1.34–1.58 for patients with SMI and no history of lithium prescription. The higher prevalence of CKD in patients with SMI may, in part, be explained by more frequent blood testing as compared to the general population. Conclusion: CKD is identified more commonly among

  1. Intravitreal anti-VEGF injection for the treatment of progressive juxtapapillary retinal capillary hemangioma: a case report and mini review of the literature

    Directory of Open Access Journals (Sweden)

    Chelala E

    2013-10-01

    Full Text Available Elias Chelala, Ali Dirani, Ali Fadlallah Saint-Joseph University, Faculty of Medicine, Beirut, Lebanon Abstract: We report a case of a patient known to have a von Hippel–Lindau disease with documented progressive juxtapapillary retinal capillary hemangioma (JRCH with well-preserved visual acuity (VA and visual field (VF. The patient received a single injection of intravitreal ranibizumab (IVR. Six months after IVR injection, the JRCH showed reduced vascularization, fibrosis, and mild shrinkage, and VA and VF remained unchanged. IVR therapy might therefore be considered as an alternative treatment for progressive JRCH, especially in patients with well-preserved VA and VF. Keywords: juxtapapillary retinal capillary hemangioma, intravitreal anti-VEGF injection, von Hippel–Lindau disease

  2. Ages of detrital zircon from siliciclastic sucessions of the Brasilia belt, southern border of Sao Francisco craton: Implications for the evolution of proterozoic basins

    International Nuclear Information System (INIS)

    Valladares, C.S; Machado, N; Ribeiro, A.; Paciullo, F.V.P; Heilbron, M; Gauthier, G

    2001-01-01

    The determination of the age distribution of detrital zircon suites from greenschist and amphibolite facies metassedimentary rocks using 207 Pb/ 206 Pb laser-ablation inductively couple plasma mass spectometry (LA-ICPMS) was previously discussed by Machado and Gauthier (1996) and is an useful tool on determinating the ages interval of the source area. Although 207 Pb/ 206 Pb ages are, in principle, mimimum ages, Feng et al. (1993) and Machado and Gauthier (1996) showed that these ages are identical within error to U-Pb ages. The advantage of the method for sedimentary provenance studies is that the number of grains that can be analysed per day (ca. 50) on the same sample, providing a stastically meaningful age distribution. The most significant limitations of the method used in this work are the inability to yield reliable U-Pb values and the large analytical error of, at least, 1-10%. Neverthless, in provenance studies high precision are not required. In this work we report ages of detrital zircon from from lower greenschist metamorphic facies quartzites from the Proterozoic Sao Joao del Rei and Andrelandia basin successions. The data yield information about the ages of the source areas and provide an approach for constraining sedimentation ages in these basins (au)

  3. Antonio Machado, cuasifotógrafo y poeta del instante

    Directory of Open Access Journals (Sweden)

    Ernesto Cortés Ahumada

    1960-10-01

    La crítica literaria, todavía mejor, el crítico de poesía suele olvidar sistemáticamente el estudio, como dirían los biólogos, de los "ingredientes últimos" de la "estructura íntima" de sus poemas o lo que podría llamarse, continuando con el símil biológico, las cromosomas líricas machadianas.

  4. Nature, Nurture, and Attention Deficit Hyperactivity Disorder.

    Science.gov (United States)

    Faraone, Stephen V.; Biederman, Joseph

    2000-01-01

    Comments on Joseph's review of the genetics of attention deficit disorder, demonstrating errors of scientific logic and oversight of relevant research in Joseph's argument. Argues for the validity of twin studies in supporting a genetic link for ADHD and for the complementary role of nature and nurture in the etiology of the disorder. (JPB)

  5. A travessia da escrita machadiana

    Directory of Open Access Journals (Sweden)

    Ruth Silviano Brandão

    2000-03-01

    Full Text Available A narração machadiana constrói-se de uma maneira tal que se pode falar de determinadas posições do sujeito da enunciação em relação a seus fantasmas. Assim, é possível pensar num trajeto que se pode chamar de travessia exatamente pelas modificações ocorridas na escritade Machado de Assis até o Memorial de Aires.

  6. Pilates and Mindfulness: A Qualitative Study

    Science.gov (United States)

    Adams, Marianne; Caldwell, Karen; Atkins, Laurie; Quin, Rebecca

    2012-01-01

    The Pilates method as Joseph Hubertus Pilates originally defined it in the early 1920s, was called "Contrology," or the art of control, based on the ideal of attaining a complete coordination of body, mind, and spirit. Joseph Pilates's early writings emphasized the value of controlling the body rather than attending to the process of body…

  7. Jesus: Born Poor or Rich? | Osai | African Research Review

    African Journals Online (AJOL)

    The paper concludes that, like tailoring, smith, masonry etc. carpentry was part of a guild that only those with means practiced in Judaea of that epoch and, therefore Joseph was not poor; that Joachim, the maternal grandfather of Jesus, was a wealthy descendant of the royal house of David; that Joseph had the means to ...

  8. Delimitation Markers, Chapter Division, Syntax and Literary Structure: the Case of Genesis 37:1–2

    NARCIS (Netherlands)

    van Peursen, W.T.; Korpel, Marjo; Sanders, Paul

    2017-01-01

    Many modern Bible translations insert a heading between the end of Genesis 36 and the beginning of Genesis 37 such as ‘Joseph and his brothers’ or ‘Joseph’s dreams’. This suggests (1) that a new section starts at 37:1 and (2) that this section contains the Joseph story. That 37:1 marks a new start

  9. Composing Self on Narrative Landscapes of Sexual Difference: A Story of Wisdom and Resilience

    Science.gov (United States)

    Estefan, Andrew; Roughley, Robert A.

    2013-01-01

    This study draws upon recent narrative inquiry research that explored the resilience experiences of 6 young same-sex-attracted men and women (4 men, 2 women; age range = 21-27). This article elucidates the story of one participant, Joseph, a 25-year-old Canadian man. As we conducted the research, Joseph's story stood out for us as having something…

  10. Joseph Louis Lagrange (1736 - 1813)

    Indian Academy of Sciences (India)

    to diverse areas of mathematics, is best remembered for his work on number theory, ... father was in the service of the King of Sardinia, the family was not wealthy, as the ... of Prussia arranged for Lagrange to be offered a position in 1765 there. ... taught courses on elementary mathematics for training school teachers.

  11. 1082-IJBCS-Article-Joseph Dioha

    African Journals Online (AJOL)

    DR GATSING

    Determination of ascorbic acid content of some tropical fruits by ... 80 oC), representing the range of temperatures the fruits may be exposed to during ... during growth and development is also ... excess iodine generated was titrated against .... of fruits with high level of vitamin C can help ... cancer that are prevalent in Africa.

  12. Nastalo vremja deistvovat / Joseph Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph

    2007-01-01

    Globaalsoojenemisega kaasnevatest ohtudest. Maailma võitlusest sooja kliima tekitatud kahjudega, Ameerika Ühendriikide mahajäämusest. Artikli autor on Ameerika majandusteadlane, Nobeli majanduspreemia laureaat

  13. Pidurdumise õppetunnid / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2001-01-01

    Turufundamentalistide väide, et turud reguleeruvad ise, on vale. Makromajaduse stabiliseerimises on valitsusel tähtis roll. IMF peaks naasma algse missiooni juurde - tagada globaalne likviidsus, et tagada pidevat globaalset arengut

  14. 1398-IJBCS-Article-Joseph Kouassi+

    African Journals Online (AJOL)

    hp

    3Université d'Abobo-Adjamé, Laboratoire de Chimie Bio-Organique et de Substances Naturelles,. 02 BP 801 Abidjan 02, Côte d'Ivoire. 4INRA Science du Sol, BP 20619, 45166 Olivet cedex, ...... Mobilité relative des métaux lourds issus de la décharge d'Akouédo et risque de contamination de la nappe du Continental.

  15. 931-IJBCS-Article-Dossou Joseph

    African Journals Online (AJOL)

    DR GATSING

    En effet, dans la région ouest africaine, les céréales les plus consommées sont, par ordre d'importance, le maïs, le riz, le mil et le sorgho; au Bénin, le maïs occupe une place de choix dans l'alimentation des populations; ceci explique le niveau significatif de consommation estimée à 85 kg/habitant/an (Nago,1997), avec ...

  16. PSR J2021+4026 IN THE GAMMA CYGNI REGION: THE FIRST VARIABLE γ-RAY PULSAR SEEN BY THE Fermi LAT

    Energy Technology Data Exchange (ETDEWEB)

    Allafort, A.; Bottacini, E.; Cameron, R. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Baldini, L. [Università di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa I-56127 Pisa (Italy); Ballet, J.; Chaves, R.C.G. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d' Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Baring, M. G. [Rice University, Department of Physics and Astronomy, MS-108, P. O. Box 1892, Houston, TX 77251 (United States); Bastieri, D.; Buson, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bellazzini, R.; Bregeon, J. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bonamente, E.; Cecchi, C. [Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, I-06123 Perugia (Italy); Brandt, T. J. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Bruel, P. [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Caliandro, G. A. [Institut de Ciències de l' Espai (IEEE-CSIC), Campus UAB, E-08193 Barcelona (Spain); Caraveo, P. A. [INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica, I-20133 Milano (Italy); Chekhtman, A., E-mail: ltibaldo@slac.stanford.edu, E-mail: massimiliano.razzano@pi.infn.it [Center for Earth Observing and Space Research, College of Science, George Mason University, Fairfax, VA 22030, resident at Naval Research Laboratory, Washington, DC 20375 (United States); and others

    2013-11-01

    Long-term monitoring of PSR J2021+4026 in the heart of the Cygnus region with the Fermi Large Area Telescope unveiled a sudden decrease in flux above 100 MeV over a timescale shorter than a week. The 'jump' was near MJD 55850 (2011 October 16), with the flux decreasing from (8.33 ± 0.08) × 10{sup –10} erg cm{sup –2} s{sup –1} to (6.86 ± 0.13) × 10{sup –10} erg cm{sup –2} s{sup –1}. Simultaneously, the frequency spindown rate increased from (7.8 ± 0.1) × 10{sup –13} Hz s{sup –1} to (8.1 ± 0.1) × 10{sup –13} Hz s{sup –1}. Significant (>5σ) changes in the pulse profile and marginal (<3σ) changes in the emission spectrum occurred at the same time. There is also evidence for a small, steady flux increase over the 3 yr preceding MJD 55850. This is the first observation at γ-ray energies of mode changes and intermittent behavior, observed at radio wavelengths for other pulsars. We argue that the change in pulsed γ-ray emission is due to a change in emission beaming and we speculate that it is precipitated by a shift in the magnetic field structure, leading to a change of either effective magnetic inclination or effective current.

  17. Physical activity patterns and estimated daily energy expenditures in normal and overweight tunisian schoolchildren.

    Science.gov (United States)

    Zarrouk, Fayçal; Bouhlel, Ezdine; Feki, Youssef; Amri, Mohamed; Shephard, Roy J

    2009-01-01

    Our aim was to test the normality of physical activity patterns and energy expenditures in normal weight and overweight primary school students. Heart rate estimates of total daily energy expenditure (TEE), active energy expenditure (AEE), and activity patterns were made over 3 consecutive school days in healthy middle-class Tunisian children (46 boys, 44 girls, median age (25(th)-75(th)) percentile, 9.2 (8.8-9.9) years. Our cross-section included 52 students with a normal body mass index (BMI) and 38 who exceeded age-specific BMI limits. TEE, AEE and overall physical activity level (PAL) were not different between overweight children and those with a normal BMI [median values (25(th)-75(th)) 9.20 (8.20-9.84) vs. 8.88 (7.42-9.76) MJ/d; 3.56 (2.59-4.22) vs. 3.85 (2.77-4.78) MJ/d and 1.74 (1.54-2.04) vs. 1.89 (1.66-2.15) respectively]. Physical activity intensities (PAI) were expressed as percentages of the individual's heart rate reserve (%HRR). The median PAI for the entire day (PAI24) and for the waking part of day (PAIw) were lower in overweight than in normal weight individuals [16.3 (14.2-18.9) vs. 20.6 (17.9-22.3) %HRR, p spend more time in moderate activity and less time in sedentary pursuits than overweight children.

  18. PSR J2021+4026 in the Gamma Cygni Region: The First Variable Gamma-Ray Pulsar Seen by the Fermi LAT

    Science.gov (United States)

    Allafort, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Bellazzini, R.; Bonamente, E.; Bottacini, E.; Brandt, T. J.; hide

    2013-01-01

    Long-term monitoring of PSR J2021+4026 in the heart of the Cygnus region with the Fermi Large Area Telescope unveiled a sudden decrease in flux above 100 MeV over a timescale shorter than a week. The "jump" was near MJD 55850 (2011 October 16), with the flux decreasing from (8.33 plus or minus 0.08)×10(exp -10) erg cm(exp -2) s(exp -1) to (6.86 plus or minus 0.13)× 10 (exp -1)0 erg cm (exp -2) s(exp -1). Simultaneously, the frequency spindown rate increased from (7.8 plus or minus 0.1) × 10(exp -13) Hz s(exp -1) to (8.1 plus or minus 0.1) × 10(exp -1)3 Hz s(exp -1). Significant (greater than 5 sigma) changes in the pulse profile and marginal (less than 3 sigma) changes in the emission spectrum occurred at the same time. There is also evidence for a small, steady flux increase over the 3 yr preceding MJD 55850. This is the first observation at gamma-ray energies of mode changes and intermittent behavior, observed at radio wavelengths for other pulsars. We argue that the change in pulsed gamma-ray emission is due to a change in emission beaming and we speculate that it is precipitated by a shift in the magnetic field structure, leading to a change of either effective magnetic inclination or effective current.

  19. ‘A man of great feeling and sensibility’: The Memoirs of Joseph Grimaldi and the Tears of a Clown

    Directory of Open Access Journals (Sweden)

    Jonathan Buckmaster

    2011-09-01

    Full Text Available In the ‘Concluding Chapter’ of his 'Memoirs of Joseph Grimaldi' (1838, Charles Dickens describes Grimaldi as ‘a man of great feeling and sensibility’, despite the fact that he thinks ‘many readers will ridicule the idea’ of a clown being capable of such emotional depth. But here Dickens is not merely a traditional biographer, summarizing the evidence and using it as the basis for an evaluation of his subject’s life. In fact, this is the carefully crafted conclusion of a narrative deliberately constructed to tell the life story of ‘a man of the kindest heart’.   The level of Dickens’s creative input in the 'Memoirs' has always been a matter for debate, but in a letter to Grimaldi’s doctor, Dickens explains how he directly shaped the way that Grimaldi’s emotional side was presented. Despite claiming his role as a mere editor, Dickens admits that ‘I was very much struck by the many traits of kindheartedness scattered through the book, and have given it that colouring throughout’, clearly signalling his focus on the sentimental side of Grimaldi’s character.   In the first section of this article, I demonstrate how Dickens provides that colouring through his shaping of the biographical material, and reconstructs Grimaldi as a real-life counterpart to Dickens’s extremely popular character of time, Mr Pickwick. Through his choice of incidents from Grimaldi’s life, and the way in which he presents the choices and actions Grimaldi takes, Dickens attempts to offer Grimaldi as an admirable model of feeling towards his fellow man.   However, in the second section of this article, I show how this biographical imperative to show Grimaldi as a man of feeling is counterposed by a contesting narrative. This second narrative is the work of the more creative writer within Dickens, and like his earlier essay ‘The Pantomime of Life’ (March 1837 it posits identity as being based on external performance and affect rather than

  20. MAXI/GSC detection of a new outburst from SAX J1810.8-2609

    Science.gov (United States)

    Negoro, H.; Mihara, T.; Nakahira, S.; Yatabe, F.; Takao, Y.; Matsuoka, M.; Kawai, N.; Sugizaki, M.; Tachibana, Y.; Morita, K.; Sakamoto, T.; Serino, M.; Sugita, S.; Kawakubo, Y.; Hashimoto, T.; Yoshida, A.; Nakajima, M.; Sakamaki, A.; Maruyama, W.; Ueno, S.; Tomida, H.; Ishikawa, M.; Sugawara, Y.; Isobe, N.; Shimomukai, R.; Ueda, Y.; Tanimoto, A.; Morita, T.; Yamada, S.; Tsuboi, Y.; Iwakiri, W.; Sasaki, R.; Kawai, H.; Sato, T.; Tsunemi, H.; Yoneyama, T.; Yamauchi, M.; Hidaka, K.; Iwahori, S.; Kawamuro, T.; Yamaoka, K.; Shidatsu, M.

    2018-05-01

    We report a new X-ray outburst from the low-mass X-ray binary SAX J1810.8-2609 (aka V4722 Sgr; Ubertini et al. 1998, IAUC 6838) observed with MAXI/GSC. The enhancement was recognized from 2018 April 23 (MJD 58231), and X-ray count rates in the 2-4 keV and 4-10 keV bands peaked on April 26 at 0.085 +/- 0.008 c/s/cm2 ( 80 mCrab) and 0.096+/-0.008 c/s/cm2 ( 82 mCrab), respectively.