Borodin, Alexei
2011-01-01
Macdonald processes are probability measures on sequences of partitions defined in terms of nonnegative specializations of the Macdonald symmetric functions and two Macdonald parameters q,t in [0,1). We prove several results about these processes, which include the following. (1) We explicitly evaluate expectations of a rich family of observables for these processes. (2) In the case t=0, we find a Fredholm determinant formula for a q-Laplace transform of the distribution of the last part of the Macdonald-random partition. (3) We introduce Markov dynamics that preserve the class of Macdonald processes and lead to new "integrable" 2d and 1d interacting particle systems. (4) In a large time limit transition, and as q goes to 1, the particles of these systems crystallize on a lattice, and fluctuations around the lattice converge to O'Connell's Whittaker process that describe semi-discrete Brownian directed polymers. (5) This yields a Fredholm determinant for the Laplace transform of the polymer partition function...
Ranald Macdonald and statistical inference.
Smith, Philip T
2009-05-01
Ranald Roderick Macdonald (1945-2007) was an important contributor to mathematical psychology in the UK, as a referee and action editor for British Journal of Mathematical and Statistical Psychology and as a participant and organizer at the British Psychological Society's Mathematics, statistics and computing section meetings. This appreciation argues that his most important contribution was to the foundations of significance testing, where his concern about what information was relevant in interpreting the results of significance tests led him to be a persuasive advocate for the 'Weak Fisherian' form of hypothesis testing.
Baxter operator formalism for Macdonald polynomials
Gerasimov, Anton; Oblezin, Sergey
2012-01-01
We develop basic constructions of the Baxter operator formalism for the Macdonald polynomials. Precisely we construct a dual pair of mutually commuting Baxter operators such that the Macdonald polynomials are their common eigenfunctions. The dual pair of Baxter operators is closely related to the dual pair of recursive operators for Macdonald polynomials leading to various families of their integral representations. We also construct the Baxter operator formalism for the q-deformed Whittaker functions and the Jack polynomials obtained by degenerations of the Macdonald polynomials. This note provides a generalization of our previous results on the Baxter operator formalism for the Whittaker functions. It was demonstrated previously that Baxter operator formalism for the Whittaker functions has deep connections with representation theory. In particular the Baxter operators should be considered as elements of appropriate spherical Hecke algebras and their eigenvalues are identified with local Archimedean L-facto...
Parabolic refined invariants and Macdonald polynomials
Chuang, Wu-yen; Donagi, Ron; Pantev, Tony
2013-01-01
A string theoretic derivation is given for the conjecture of Hausel, Letellier, and Rodriguez-Villegas on the cohomology of character varieties with marked points. Their formula is identified with a refined BPS expansion in the stable pair theory of a local root stack, generalizing previous work of the first two authors in collaboration with G. Pan. Haiman's geometric construction for Macdonald polynomials is shown to emerge naturally in this context via geometric engineering. In particular this yields a new conjectural relation between Macdonald polynomials and refined local orbifold curve counting invariants. The string theoretic approach also leads to a new spectral cover construction for parabolic Higgs bundles in terms of holomorphic symplectic orbifolds.
Quantum Hurwitz numbers and Macdonald polynomials
Harnad, J
2015-01-01
Parametric families in the centre ${\\bf Z}({\\bf C}[S_n])$ of the group algebra of the symmetric group are obtained by identifying the indeterminates in the generating function for Macdonald polynomials as commuting Jucys-Murphy elements. Their eigenvalues provide coefficients in the double Schur function expansion of 2D Toda $\\tau$-functions of hypergeometric type. Expressing these in the basis of products of power sum symmetric functions, the coefficients may be interpreted geometrically as parametric families of quantum Hurwitz numbers, enumerating weighted branched coverings of the Riemann sphere. Combinatorially, they give quantum weighted sums over paths in the Cayley graph of $S_n$ generated by transpositions. Dual pairs of bases for the algebra of symmetric functions with respect to the scalar product in which the Macdonald polynomials are orthogonal provide both the geometrical and combinatorial significance of these quantum weighted enumerative invariants.
Earth tides in MacDonald's model
Ferraz-Mello, S
2013-01-01
We expand the equations used in MacDonald's 1964 theory and Fourier analyze the tidal variations of the height at one point on the Earth surface, and also the tidal potential at such point. It is shown that no intrinsic law is relating the lag of the tide components to their frequencies. In other words, no simple rheology is being intrinsically fixed by MacDonald's equations. The same is true of the modification proposed by Singer(1968). At variance with these two cases, the modification proposed by Williams and Efroimsky (2012) fix the standard Darwin rheology in which the lags are proportional to the frequencies and their model is, in this sense, equivalent to Mignard's 1979 formulation of Darwin's theory.
Macdonald formula for curves with planar singularities
Maulik, Davesh
2011-01-01
We generalize Macdonald's formula for the cohomology of Hilbert schemes of points on a curve from smooth curves to curves with planar singularities: we relate the cohomology of the Hilbert schemes to the cohomology of the compactified Jacobian of the curve. The new formula is a consequence of a stronger identity between certain perverse sheaves defined by a family of curves satisfying mild conditions, whose proof makes an essential use of Ng\\^o's support theorem for compactified Jacobians.
Haglund's conjecture on 3-column Macdonald polynomials
Blasiak, Jonah
2014-01-01
We prove a positive combinatorial formula for the Schur expansion of LLT polynomials indexed by a 3-tuple of skew shapes. This verifies a conjecture of Haglund. The proof requires expressing a noncommutative Schur function as a positive sum of monomials in Lam's algebra of ribbon Schur operators. Combining this result with the expression of Haglund, Haiman, and Loehr for transformed Macdonald polynomials in terms of LLT polynomials then yields a positive combinatorial rule for transformed Mac...
A New Generalisation of Macdonald Polynomials
Garbali, Alexandr; de Gier, Jan; Wheeler, Michael
2017-01-01
We introduce a new family of symmetric multivariate polynomials, whose coefficients are meromorphic functions of two parameters (q, t) and polynomial in a further two parameters (u, v). We evaluate these polynomials explicitly as a matrix product. At u = v = 0 they reduce to Macdonald polynomials, while at q = 0, u = v = s they recover a family of inhomogeneous symmetric functions originally introduced by Borodin.
A Summation Formula for Macdonald Polynomials
de Gier, Jan; Wheeler, Michael
2016-03-01
We derive an explicit sum formula for symmetric Macdonald polynomials. Our expression contains multiple sums over the symmetric group and uses the action of Hecke generators on the ring of polynomials. In the special cases {t = 1} and {q = 0}, we recover known expressions for the monomial symmetric and Hall-Littlewood polynomials, respectively. Other specializations of our formula give new expressions for the Jack and q-Whittaker polynomials.
On form factors and Macdonald polynomials
Lashkevich, Michael
2013-01-01
We are developing the algebraic construction for form factors of local operators in the sinh-Gordon theory proposed in [B.Feigin, M.Lashkeivch, 2008]. We show that the operators corresponding to the null vectors in this construction are given by the degenerate Macdonald polynomials with rectangular partitions and the parameters $t=-q$ on the unit circle. We obtain an integral representation for the null vectors and discuss its simple applications.
DEFF Research Database (Denmark)
from the original phonetic transcription to the conventional orthography). Much unpublished work, ranging from lecture notes on the sound systems of French, Spanish and Italian, to hitherto unpublished details of Jones' dealings with celebrities such as George Bernard Shaw and the Poet Laureate Robert...
DEFF Research Database (Denmark)
Daniel Jones (1881-1967) played a significant role in the emergence of phonetics as a fully developed academic discipline in the first half of the twentieth century. His views on the subject not only provided the foundations for the British tradition but also had a considerable, and often underra...
Wilson disease is a rare inherited disorder that prevents your body from getting rid of extra copper. You ... extra copper into bile, a digestive fluid. With Wilson disease, the copper builds up in your liver, and ...
... in copper, such as –shellfish –liver –mushrooms –nuts –chocolate • A person cannot prevent Wilson disease; however, people with a family history of Wilson disease, especially those with an affected ...
On Factorization of Generalized Macdonald Polynomials
Kononov, Ya
2016-01-01
A remarkable feature of Schur functions -- the common eigenfunctions of cut-and-join operators from $W_\\infty$ -- is that they factorize at the peculiar two-parametric topological locus in the space of time-variables, what is known as the hook formula for quantum dimensions of representations of $U_q(SL_N)$ and plays a big role in various applications. This factorization survives at the level of Macdonald polynomials. We look for its further generalization to generalized Macdonald polynomials (GMP), associated in the same way with the toroidal Ding-Iohara-Miki algebras, which play the central role in modern studies in Seiberg-Witten-Nekrasov theory. In the simplest case of the first-coproduct eigenfunctions, where GMP depend on just two sets of time-variables, we discover a weak factorization -- on a one- (rather than four-) parametric slice of the topological locus, what is already a very non-trivial property, calling for proof and better understanding.
On factorization of generalized Macdonald polynomials
Kononov, Ya.; Morozov, A.
2016-08-01
A remarkable feature of Schur functions—the common eigenfunctions of cut-and-join operators from W_∞ —is that they factorize at the peculiar two-parametric topological locus in the space of time variables, which is known as the hook formula for quantum dimensions of representations of U_q(SL_N) and which plays a big role in various applications. This factorization survives at the level of Macdonald polynomials. We look for its further generalization to generalized Macdonald polynomials (GMPs), associated in the same way with the toroidal Ding-Iohara-Miki algebras, which play the central role in modern studies in Seiberg-Witten-Nekrasov theory. In the simplest case of the first-coproduct eigenfunctions, where GMP depend on just two sets of time variables, we discover a weak factorization—on a one- (rather than four-) parametric slice of the topological locus, which is already a very non-trivial property, calling for proof and better understanding.
On factorization of generalized Macdonald polynomials
Energy Technology Data Exchange (ETDEWEB)
Kononov, Ya. [Landau Institute for Theoretical Physics, Chernogolovka (Russian Federation); HSE, Math Department, Moscow (Russian Federation); Morozov, A. [ITEP, Moscow (Russian Federation); Institute for Information Transmission Problems, Moscow (Russian Federation); National Research Nuclear University MEPhI, Moscow (Russian Federation)
2016-08-15
A remarkable feature of Schur functions - the common eigenfunctions of cut-and-join operators from W{sub ∞} - is that they factorize at the peculiar two-parametric topological locus in the space of time variables, which is known as the hook formula for quantum dimensions of representations of U{sub q}(SL{sub N}) and which plays a big role in various applications. This factorization survives at the level of Macdonald polynomials. We look for its further generalization to generalized Macdonald polynomials (GMPs), associated in the same way with the toroidal Ding-Iohara-Miki algebras, which play the central role in modern studies in Seiberg-Witten-Nekrasov theory. In the simplest case of the first-coproduct eigenfunctions, where GMP depend on just two sets of time variables, we discover a weak factorization - on a one- (rather than four-) parametric slice of the topological locus, which is already a very non-trivial property, calling for proof and better understanding. (orig.)
Kuznetsov, V B
1996-01-01
Using the Baker-Akhiezer function technique we construct a separation of variables for the classical trigonometric 3-particle Ruijsenaars model (relativistic generalization of Calogero-Moser-Suthe rland model). In the quantum case, an integral operator M is constructed from the Askey-Wilson contour integral. The operator M transforms the eigenfunctions of the commuting Hamiltonians (Macdonald polynomials for the root sytem A2) into the factorized form S(y1)S(y2) where S(y) is a Laurent polynomial of one variable expressed in terms of the 3phi2(y) basic hypergeometric series. The inversion of M produces a new integral representation for the A2 Macdonald polynomials. We also present some results and conjectures for general n-particle case.
Macdonald polynomials in superspace as eigenfunctions of commuting operators
Blondeau-Fournier, O; Lapointe, L; Mathieu, P
2012-01-01
A generalization of the Macdonald polynomials depending upon both commuting and anticommuting variables has been introduced recently. The construction relies on certain orthogonality and triangularity relations. Although many superpolynomials were constructed as solutions of highly over-determined system, the existence issue was left open. This is resolved here: we demonstrate that the underlying construction has a (unique) solution. The proof uses, as a starting point, the definition of the Macdonald superpolynomials in terms of the Macdonald non-symmetric polynomials via a non-standard (anti)symmetrization and a suitable dressing by anticommuting monomials. This relationship naturally suggests the form of two family of commuting operators that have the defined superpolynomials as their common eigenfunctions. These eigenfunctions are then shown to be triangular and orthogonal. Up to a normalization, these two conditions uniquely characterize these superpolynomials. Moreover, the Macdonald superpolynomials ar...
... prevent organ damage. Changes in Eating, Diet, and Nutrition People with Wilson disease should reduce their dietary copper intake by avoiding foods that are high in copper, such as shellfish liver mushrooms nuts chocolate People should not eat these foods during the ...
Combinatorial theory of Macdonald polynomials I: Proof of Haglund's formula
Haglund, J.; Haiman, M.; Loehr, N
2005-01-01
Haglund recently proposed a combinatorial interpretation of the modified Macdonald polynomials H̃μ. We give a combinatorial proof of this conjecture, which establishes the existence and integrality of H̃μ. As corollaries, we obtain the cocharge formula of Lascoux and Schützenberger for Hall–Littlewood polynomials, a formula of Sahi and Knop for Jack's symmetric functions, a generalization of this result to the integral Macdonald polynomials Jμ, a formula for H̃μ in terms of Lascoux–Leclerc–Th...
Whittaker Vector of Deformed Virasoro Algebra and Macdonald Symmetric Functions
Yanagida, Shintarou
2016-03-01
We give a proof of Awata and Yamada's conjecture for the explicit formula of Whittaker vector of the deformed Virasoro algebra realized in the Fock space. The formula is expressed as a summation over Macdonald symmetric functions with factored coefficients. In the proof, we fully use currents appearing in the Fock representation of Ding-Iohara-Miki quantum algebra.
Loudianos, G; Gitlin, J D
2000-01-01
Wilson's disease is an autosomal recessive disorder of copper metabolism resulting from the absence or dysfunction of a copper transporting P-type ATPase encoded on chromosome 13. This ATPase is expressed in hepatocytes where it is localized to the trans-Golgi network and transports copper into the secretory pathway for incorporation into ceruloplasmin and excretion into the bile. Under physiologic circumstances, biliary excretion represents the sole mechanism for copper excretion, and thus affected individuals have progressive copper accumulation in the liver. When the capacity for hepatic storage is exceeded, cell death ensues with copper release into the plasma, hemolysis, and tissue deposition. Presentation in childhood may include chronic hepatitis, asymptomatic cirrhosis, or acute liver failure. In young adults, neuropsychiatric symptoms predominate and include dystonia, tremor, personality changes, and cognitive impairments secondary to copper accumulation in the central nervous system. The laboratory diagnosis of Wilson's disease is confirmed by decreased serum ceruloplasmin, increased urinary copper content, and elevated hepatic copper concentration. Molecular genetic analysis is complex as more than 100 unique mutations have been identified and most individuals are compound heterozygotes. Copper chelation with penicillamine is an effective therapy in most patients and hepatic transplantation is curative in individuals presenting with irreversible liver failure. Elucidation of the molecular genetic basis of Wilson's disease has permitted new insights into the mechanisms of cellular copper homeostasis.
On the existence of Jones birefringence and Jones dichroism.
Arteaga, Oriol
2010-05-01
We claim that the so-called Jones birefringence and Jones dichroism effects, understood as new optical phenomena of difficult experimental observation, cannot be deduced from Jones publications and were proposed due to a misinterpretation of his original work.
Institute of Scientific and Technical Information of China (English)
HAN You-fa; YAN Xin-ming; LV Li-li
2012-01-01
In this paper,we discuss the properties of the colored Jones function of knots.Particularly,we calculate the colored Jones function of some knots(31,41,51,52).Furthermore,one can compute the Kashaev's invariants and study some properties of the Kashaev's conjecture.
Koltunud Indiana Jones / Kutt Kommel
Kommel, Kutt
2008-01-01
Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008
Koltunud Indiana Jones / Kutt Kommel
Kommel, Kutt
2008-01-01
Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008
Whittaker vector of deformed Virasoro algebra and Macdonald symmetric functions
Yanagida, Shintarou
2014-01-01
We give a proof of Awata and Yamada's conjecture for the explicit formula of Whittaker vector of the deformed Virasoro algebra realized in the Fock space. The formula is expressed as a summation over Macdonald symmetric functions with factored coefficients. In the proof we fully use currents appearing in the Fock representation of Ding-Iohara-Miki quantum algebra. We also mention an interpretation of Whittaker vector in terms of the geometry of the Hilbert schemes of points on the affine plane.
Lam, Lewis Y. W.; Weatherhead, Robert G.
2015-01-01
We report a case of tympanic membrane rupture during snorkeling in a 17-year-old young man who had previously undergone bilateral Jones tubes placed for epiphora. To our knowledge, this phenomenon has not been previously reported.
Lam, Lewis Y W; Weatherhead, Robert G
2015-01-01
We report a case of tympanic membrane rupture during snorkeling in a 17-year-old young man who had previously undergone bilateral Jones tubes placed for epiphora. To our knowledge, this phenomenon has not been previously reported.
Baker-Akhiezer functions and generalised Macdonald-Mehta integrals
Feigin, M. V.; Hallnäs, M. A.; Veselov, A. P.
2013-05-01
For the rational Baker-Akhiezer functions associated with special arrangements of hyperplanes with multiplicities we establish an integral identity, which may be viewed as a generalisation of the self-duality property of the usual Gaussian function with respect to the Fourier transformation. We show that the value of properly normalised Baker-Akhiezer function at the origin can be given by an integral of Macdonald-Mehta type and explicitly compute these integrals for all known Baker-Akhiezer arrangements. We use the Dotsenko-Fateev integrals to extend this calculation to all deformed root systems, related to the non-exceptional basic classical Lie superalgebras.
[Tributes to Macdonald Critchley and his achievements in neurolinguistics].
Hung, Tsu-Pei
2008-06-01
Macdonald Critchley, a world renowned neurologist, is best remembered as the person who challenged to solve the mystery and enigma of higher cerebral functions. He was the author of over 200 published articles and 20 books on neurology including his pioneer work on developmental dyslexia, the parietal lobe, cerebral hemisphere dominance and aphasiology. He also published articles on migraine, epilepsy, dementia, visual perseveration, anterior cerebral artery syndromes, indifference to pain, sleep disorders, movement disorders, and myotonia. He was very erudite and talented in linguistics; his interests were broad and eclectic. He wrote extensively on non-medical topics, such as plays, horror stories, mythology, and biographies of distinguished neuroscientists, philosophers or artists. His articles were written in the elegant prose style with thorough reference citations and extensive reviews of the literature worldwide. He was born in Bristol in 1900. From an early age, he was fascinated with the functioning brain and retained a life-long interest in languages. He was appointed to the Consultant staff of the National Hospital, Queen Square, and to King's College Hospital at the age of 27, and was elected to become FRCP at 30. He was Dean of the Institute of Neurology from 1948 to 1953. When I was studying advanced neurology at Queen Square in 1960-1961, I was fascinated by his outstanding lectures on Huntington's Disease and Non-verbal Communication. Although he did not read the manuscripts and used only a few slides for illustrations in his lectures, he could describe the details of historical accounts and relevant figures. He was an altruistic, instructive teacher with keen attention to responses from the audience. His clinical demonstrations, teaching rounds and tutorials were hugely popular among postgraduate students from all over the world. He emphasized the importance of shrewd observation and careful history taking in neurological practice. Macdonald
Jones, Ernest Beachcroft; Kingham, Edward G; Radnai, Rudolf
1985-01-01
Jones' Instrument Technology, Volume 5: Automatic Instruments and Measuring Systems deals with general trends in automatic instruments and measuring systems. Specific examples are provided to illustrate the principles of such devices. A brief review of a considerable number of standards is undertaken, with emphasis on the IEC625 Interface System. Other relevant standards are reviewed, including the interface and backplane bus standards. This volume is comprised of seven chapters and begins with a short introduction to the principles of automatic measurements, classification of measuring system
Rooted Deep: Discovering the Literary Identity of Mythopoeic Fantasist George Macdonald
Directory of Open Access Journals (Sweden)
Jeffrey Johnson Kirstin
2014-12-01
Full Text Available This paper is a conversational reassessment of George MacDonald, the Victorian fantasist who so profoundly shaped such writers as C.S. Lewis and J.R.R. Tolkien. Primary research challenges the common portrayal of MacDonald as an accidental novelist, revealing instead his clear trajectory and vocation as a devoted literary scholar. Clarifying the definition of mythopoeic as applied by the Oxford Inklings to MacDonald draws attention to their conviction that attentive response to one’s literary roots is what engenders novel literature with transformative potential. Further research proves this to be in keeping with the work and legacy of MacDonald and his mentor A.J. Scott. An intentional participation in this relational nature of literary tradition is a crucial element of the work and legacy to which the Inklings and their successors are heirs.
Ross, macdonald, and a theory for the dynamics and control of mosquito-transmitted pathogens.
Smith, David L; Battle, Katherine E; Hay, Simon I; Barker, Christopher M; Scott, Thomas W; McKenzie, F Ellis
2012-01-01
Ronald Ross and George Macdonald are credited with developing a mathematical model of mosquito-borne pathogen transmission. A systematic historical review suggests that several mathematicians and scientists contributed to development of the Ross-Macdonald model over a period of 70 years. Ross developed two different mathematical models, Macdonald a third, and various "Ross-Macdonald" mathematical models exist. Ross-Macdonald models are best defined by a consensus set of assumptions. The mathematical model is just one part of a theory for the dynamics and control of mosquito-transmitted pathogens that also includes epidemiological and entomological concepts and metrics for measuring transmission. All the basic elements of the theory had fallen into place by the end of the Global Malaria Eradication Programme (GMEP, 1955-1969) with the concept of vectorial capacity, methods for measuring key components of transmission by mosquitoes, and a quantitative theory of vector control. The Ross-Macdonald theory has since played a central role in development of research on mosquito-borne pathogen transmission and the development of strategies for mosquito-borne disease prevention.
Product Integrals and Wilson loops
Karp, R L
2001-01-01
Using product integrals we review the unambiguous mathematical representation of Wilson line and Wilson loop operators, including their behavior under gauge transformations and the non-abelian Stokes theorem. Interesting consistency conditions among Wilson lines are also presented.
Tagging, Encoding, and Jones Optimality
DEFF Research Database (Denmark)
Danvy, Olivier; López, Pablo Ernesto Martínes
2003-01-01
A partial evaluator is said to be Jones-optimal if the result of specializing a self-interpreter with respect to a source program is textually identical to the source program, modulo renaming. Jones optimality has already been obtained if the self-interpreter is untyped. If the selfinterpreter is...
Indiana Jones ja kristallpealuu kuningriik / Jaanus Noormets
Noormets, Jaanus
2008-01-01
Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008
Indiana Jones ja kristallpealuu kuningriik / Jaanus Noormets
Noormets, Jaanus
2008-01-01
Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008
Koornwinder, T.H.
2012-01-01
Askey-Wilson polynomial refers to a four-parameter family of q-hypergeometric orthogonal polynomials which contains all families of classical orthogonal polynomials (in the wide sense) as special or limit cases.
Wilson's Disease Association International
... of Colorado and graduated with a B.S. in finance. Latest News & Announcements Search Our Site About WDA ... Help Donate Volunteer Shop Online Search the Internet Corporate Sponsorship Marketplace Copyright © 1978 - 2017 The Wilson Disease ...
Tagging, Encoding, and Jones Optimality
DEFF Research Database (Denmark)
Danvy, Olivier; Lopez, Pablo E. Martinez
2003-01-01
A partial evaluator is said to be Jones-optimal if the result of specializing a self-interpreter with respect to a source program is textually identical to the source program, modulo renaming. Jones optimality has already been obtained if the self-interpreter is untyped. If the selfinterpreter...... is typed, however, residual programs are cluttered with type tags. To obtain the original source program, these tags must be removed. A number of sophisticated solutions have already been proposed. We observe, however, that with a simple representation shift, ordinary partial evaluation is already Jones-optimal...
Stabiilne Ashley Jones / Svea Suvi
Suvi, Svea
2006-01-01
Ameerika teleseriaali "Vaprad ja ilusad" ("The Bold and the Beautiful") osatäitja Ashley Jones (Bridget Forrester). Sama artikkel pealkirjaga "Uus Bridget" : Nädal, 30. jan. 2006, nr. 4, lk. 12 : ill
Stabiilne Ashley Jones / Svea Suvi
Suvi, Svea
2006-01-01
Ameerika teleseriaali "Vaprad ja ilusad" ("The Bold and the Beautiful") osatäitja Ashley Jones (Bridget Forrester). Sama artikkel pealkirjaga "Uus Bridget" : Nädal, 30. jan. 2006, nr. 4, lk. 12 : ill
Magnetoelectric Jones Dichroism in Atoms
Budker, D
2003-01-01
The authors suggest that atomic experiments measuring the interference between magnetic-dipole and electric-field-induced electric-dipole transition amplitudes may provide a valuable system to study magnetoelectric Jones effects.
A double index transform with a product of Macdonald's functions revisited
Directory of Open Access Journals (Sweden)
Semyon B. Yakubovich
2009-01-01
Full Text Available We prove an inversion theorem for a double index transform, which is associated with the product of Macdonald's functions \\(K_{i \\tau}(\\sqrt{x^2+y^2}-y K_{i \\tau}(\\sqrt{x^2+y^2}+y\\, where \\((x, y \\in \\mathbb{R}_+ \\times \\mathbb{R}_+\\ and \\(i \\tau, \\tau \\in \\mathbb{R}_+\\ is a pure imaginary index. The results obtained in the sequel are applied to find particular solutions of integral equations involving the square and the cube of the Macdonald function \\(K_{i \\tau}(t\\ as a kernel.
Brzoska, A M; Negele, J W; Thies, M
2004-01-01
A phenomenological analysis of the distribution of Wilson loops in SU(2) Yang-Mills theory is presented in which Wilson loop distributions are described as the result of a diffusion process on the group manifold. It is shown that, in the absence of forces, diffusion implies Casimir scaling and, conversely, exact Casimir scaling implies free diffusion. Screening processes occur if diffusion takes place in a potential. The crucial distinction between screening of fundamental and adjoint loops is formulated as a symmetry property related to the center symmetry of the underlying gauge theory. The results are expressed in terms of an effective Wilson loop action and compared with various limits of SU(2) Yang-Mills theory.
Berlin, Isaiah
2012-01-01
In this 1960 article Isaiah Berlin compares Woodrow Wilson's emphasis on the need to educate university students for life in the real world with the difference between Oxford "realism" and Cambridge "idealism" in the nineteenth century. Oxford favoured a Wilsonian preference for general education over (but not to the exclusion of) pure…
Berlin, Isaiah
2012-01-01
In this 1960 article Isaiah Berlin compares Woodrow Wilson's emphasis on the need to educate university students for life in the real world with the difference between Oxford "realism" and Cambridge "idealism" in the nineteenth century. Oxford favoured a Wilsonian preference for general education over (but not to the exclusion of) pure…
Genesis: The Brynmor Jones Report
MacKenzie, Norman
2005-01-01
An account of the impetus given by the Brynmor Jones report ("Audio visual aids in Higher Education", 1965) to the development of educational technology in Britain. The author, who was closely involved in the developments, discusses the influence of the audio-visual movement in the United States and the emergence of a national organisation (NCET)…
No More Indiana Jones Warehouses
Pannapacker, William
2012-01-01
In "Raiders of the Lost Ark," Indiana Jones--perhaps the last heroic professor to appear in a major Hollywood film--survives a series of adventures involving spiders, snakes, treacherous colleagues, and countless Nazis who are determined to recover the ark of the covenant for their "Fuhrer." Apparently the ark has mystical powers. Ultimately,…
Chiral Dynamics With Wilson Fermions
Splittorff, K
2012-01-01
Close to the continuum the lattice spacing affects the smallest eigenvalues of the Wilson Dirac operator in a very specific manner determined by the way in which the discretization breaks chiral symmetry. These effects can be computed analytically by means of Wilson chiral perturbation theory and Wilson random matrix theory. A number of insights on chiral Dynamics with Wilson fermions can be obtained from the computation of the microscopic spectrum of the Wilson Dirac operator. For example, the unusual volume scaling of the smallest eigenvalues observed in lattice simulations has a natural explanation. The dynamics of the eigenvalues of the Wilson Dirac operator also allow us to determine the additional low energy constants of Wilson chiral perturbation theory and to understand why the Sharpe-Singleton scenario is only realized in unquenched simulations.
Wilson's disease in pregnancy.
Zegarac, Zana; Duić, Zeljko; Stasenko, Sandra; Partl, Jasenka Zmijanac; Valetić, Josip; Cvrlje, Vesna Colić
2013-12-01
Wilson's disease is a rare autosomal recessive disorder of copper metabolism. It causes cirrhosis of the liver, consequently followed by disorder of the menstrual cycle and infertility. Successful decopperizing may lead to restoration of the ovulatory cycle and enable pregnancy. Increased copper levels may cause preeclampsia, intrauterine growth restriction and neurologic damages in the fetus. Pregnant women with decompensated liver cirrhosis face more complications, including bleeding from esophageal varices, liver failure, encephalopathy, and rupture of the splenic artery. We present a case of Wilson's disease in a patient who had spontaneously conceived three times. The first pregnancy ended with delivery of a healthy baby at term. In second pregnancy, medically induced abortion was performed in the 12th week because of deterioration of the underlying disease, liver cirrhosis with portal hypertension. In the same year, the patient underwent liver transplantation. Two years after the transplantation, the patient spontaneously conceived and delivered vaginally a healthy child.
Wilsons Disease: Diagnostic Approach
Directory of Open Access Journals (Sweden)
Hakan Gelincik
2015-06-01
Full Text Available Wilson disease (WD is an autosomal recessive disorder of copper transport caused by mutations in the ATP7B gene that encodes a P-type copper ATPase, ATP7B. In WD, a mutated dysfunctional ATP7B leads to a progressive accumulation of Cu in the liver and brain. Clinically, WND shows considerable phenotypic variability including fulminant hepatic failure, hemolysis, chronic liver disease, such as hepatitis and cirrhosis, and neuro-psychiatric disease with or without hepatic involvement. An 18 -year-old female patient who has the diagnosis of Wilson s disease was referred from outside center for genetic counseling. The mutations p.M1169T was identified in the homozygous form. [Cukurova Med J 2015; 40(2.000: 345-352
Van der Veken, Frederik F
2014-01-01
Wilson lines, being comparators that render non-local operator products gauge invariant, are extensively used in QCD calculations, especially in small-$x$ calculations, calculations concerning validation of factorisation schemes and in calculations for constructing or modelling parton density functions. We develop an algorithm to express piecewise path ordered exponentials as path ordered integrals over the separate segments, and apply it on linear segments, reducing the number of diagrams needed to be calculated. We show how different linear path topologies can be related using their colour structure. This framework allows one to easily switch results between different Wilson line structures, which is especially useful when testing different structures against each other, e.g. when checking universality properties of non-perturbative objects.
DEFF Research Database (Denmark)
Engenheiro, E; Møller, R S; Pinto, M
2008-01-01
Mowat-Wilson syndrome (MWS) is an autosomal dominant developmental disorder with mental retardation and variable multiple congenital abnormalities due to mutations of the ZEB2 (ZFHX1B) gene at 2q22. MWS was first described in 1998 and the causative gene was delineated in 2001. Since then, 115 dif...... was established only after finding of disruption of the ZEB2 gene by a balanced translocation breakpoint and an interstitial microdeletion, respectively....
Hypersialorrhea in Wilson's Disease.
Trocello, Jean-Marc; Osmani, Karima; Pernon, Michaela; Chevaillier, Gérard; de Brugière, Claire; Remy, Pascal; Wenisch, Emilie; Cousin, Catherine; Girardot-Tinant, Nadège; Woimant, France
2015-10-01
Hypersialorrhea, corresponding to excessive salivation is a symptom frequently reported in Wilson's disease, especially in its neurological form. The prevalence of this frequent complaint has not been often evaluated. During a 7-month period, 87 consecutive Wilson's disease patients answered to the simple question "do you have the sensation of excess saliva in your mouth?" to evaluate the frequency of this symptom. A sub-sample of 10 consecutive Wilson's disease patients with drooling was recruited to undergo quantitative and qualitative measures to evaluate the mechanism of hypersialorrhea. Excessive drooling or excess saliva was found in 46 % of patients followed at the French Reference Centre. Ninety-eight percent of them presented neurological symptoms and drooling was found in only one patient without neurological symptoms. Our study showed that patients with a complaint of excessive saliva produced significantly higher quantities of saliva at rest than controls. Endoscopic examination was abnormal in six patients. A significant decrease of swallowing frequency, longer swallow latencies, and poor swallowing capacities may partly explain the salivary stasis. Oropharyngeal sensitivity disorders were present in 50 % of our patients. The decrease of the swallowing frequency observed in all patients could be related to cognitive and behavioral abnormalities with initiation difficulties objectified by longer latencies triggered by all the ingested volumes. This study confirmed the hypothesis of a multifactorial origin of hypersialorrhea in patients who have been diagnosed in Wilson's disease. It was essential to evaluate drooling with a multidisciplinary consultation to better identify the underlying mechanisms and to implement strategies for speech therapy and therapeutic adaptation.
Casoratian Identities for the Wilson and Askey-Wilson Polynomials
Odake, Satoru
2013-01-01
Infinitely many Casoratian identities are derived for the Wilson and Askey-Wilson polynomials in parallel to the Wronskian identities for the Hermite, Laguerre and Jacobi polynomials, which were reported recently by the present authors. These identities form the basis of the equivalence between eigenstate adding and deleting Darboux transformations for solvable (discrete) quantum mechanical systems. Similar identities hold for various reduced form polynomials of the Wilson and Askey-Wilson polynomials, e.g. the continuous q-Jacobi, continuous (dual) (q-)Hahn, Meixner-Pollaczek, Al-Salam-Chihara, continuous (big) q-Hermite, etc.
Conversations with...Hannah Jones
Directory of Open Access Journals (Sweden)
Amy Hinterberger
2014-03-01
Full Text Available Hannah Jones has conducted research on multiculture and multiculturalism, local government policy-making, community cohesion policy, migration policy, voluntary and community sector organising, regeneration and urban studies, and diversity and inequality. She is currently leading one of the first research projects funded by the ESRC Urgency Grants Mechanism, entitled '"Go Home": Mapping the unfolding controversy of Home Office Immigration Campaigns', working with colleagues at six other universities across the UK.
Energy Technology Data Exchange (ETDEWEB)
Green, Daniel; /SLAC /Stanford U., Dept. Phys.
2008-04-29
Gravitational theories do not admit gauge invariant local operators. We study the limits under which there exists a quasi-local description for a class of non-local gravitational observables where a sum over worldlines plays the role of the Wilson line for gauge theory observables. We study non-local corrections to the local description and circumstances where these corrections become large. We find that these operators are quasi-local in at space and AdS, but fail to be quasi-local in de Sitter space.
Supersymmetric Open Wilson Lines
Baker, Edward B
2011-01-01
In this paper we study Open Wilson Lines (OWL's) in the context of two Supersymmetric Yang Mills theories. First we consider four dimensional N=2 Supersymmetric Yang Mills Theory with hypermultiplets transforming in the fundamental representation of the gauge group, and find supersymmetric OWL's only in the superconformal versions of these theories. We then consider four dimensional N=4 SYM coupled to a three dimensional defect hypermultiplet. Here there is a semi-circular supersymmetric OWL, which is related to the ray by a conformal transformation. We perform a perturbative calculation of the operators in both theories, and discuss using localization to compute them non-perturbatively.
[Jacqueline Wilson. Tracy Beakeri sari] / Krista Kivisalu
Kivisalu, Krista, 1968-
2016-01-01
Tutvustus: Wilson, Jacqueline. Tracy Beakeri lugu. [Tallinn] : Pegasus, 2015 ; Wilson, Jacqueline. Pühadeüllatus. [Tallinn] : Pegasus, c2015 ; Wilson, Jacqueline. Julgusmäng. [Tallinn] : Pegasus, c2015
[Jacqueline Wilson. Tracy Beakeri sari] / Krista Kivisalu
Kivisalu, Krista, 1968-
2016-01-01
Tutvustus: Wilson, Jacqueline. Tracy Beakeri lugu. [Tallinn] : Pegasus, 2015 ; Wilson, Jacqueline. Pühadeüllatus. [Tallinn] : Pegasus, c2015 ; Wilson, Jacqueline. Julgusmäng. [Tallinn] : Pegasus, c2015
Wilson's disease: a diagnostic dilemma.
Nazer, H; Larcher, V F; Ede, R J; Mowat, A P; Williams, R.
1983-01-01
A 13 year old boy presented with headache, sore throat, myalgia, and fever and subsequently developed haemolytic anaemia and acute liver failure. Wilson's disease, a rare cause of acute liver failure, was diagnosed at necropsy. In such cases Wilson's disease must be diagnosed at an early stage for treatment to be effective. The most reliable indications are increased urinary and hepatic copper concentrations.
Robert Wilson og muscial formatet
DEFF Research Database (Denmark)
Eigtved, Michael
2002-01-01
Artiklen undersøger hvordan Robert Wilson og Tom Waits' forestilling The Black Rider (1995) forholder sig til musicalkonventionerne......Artiklen undersøger hvordan Robert Wilson og Tom Waits' forestilling The Black Rider (1995) forholder sig til musicalkonventionerne...
Genetics Home Reference: Wilson disease
... body. Mutations in the ATP7B gene prevent the transport protein from functioning properly. With a shortage of functional ... GeneReview: Wilson Disease MedlinePlus Encyclopedia: Wilson's disease National Human Genome Research Institute General Information from MedlinePlus (5 ...
Guerra Montero, Luis; Ortega Álvarez, Félix; Sumire Umeres, Julia; Cok García, Jaime
2015-01-01
Wilson disease (WD) is a disorder of copper metabolism that is inherited as an autosomal recessive, which produces toxic copper accumulation mainly in the liver and brain, in general has two ways presentation, liver at early ages and neurological in later ages. We present the case of a female patient of 21 years diagnosed of WD in liver cirrhosis that started with an edematous ascites without any neurological symptoms despite the age. Their laboratory studies showed decrease in serum ceruloplasmin and high cupruria within 24 hours of the disease , characteristic data of WD. Although WD is not a common disease should be suspected in all chronic liver disease of unknown etiology with negative viral markers and autoimmunity with or without neurological manifestations as soon as posible and starting treatment with copper chelating mainly leads to a substantial improvement the prognosis of these patients.
Wilson's Disease and Hepatic Transplantation
Institute of Scientific and Technical Information of China (English)
唐荣华; 薛峥; 叶启发
2002-01-01
Summary: To investigate the changes in neurological symptoms and signs, as well as serum copper,serum ceruloplasmin after hepatic transplantation in patients with Wilson's disease, neurological symptoms and signs, serum copper, serum ceruloplasmin before and after hepatic transplantation in18 patients with Wilson's disease were observed, and those changes were followed up in 20 non-oper ative controls treated with penicillamine. Our results showed that the neurological symptoms and signs, serum copper and serum ceruloplasmin were improved in the operative group but deteriorated in the non-operative control group. Our study showed that hepatic transplantation is better than peni cillamine in the treatment of Wilson's disease.
Gallagher, Timothy
2014-07-01
When I began my medical student clinical rotations, I quickly became overwhelmed by feelings of inadequacy. While the doctors around me conjured appropriate diagnoses and treatment approaches, I fumbled with the only tools I possessed: my time and a smile. It was only when I met the patient Ms Jones that I came to understand the potential impact of these simple tools. My encouragement became part of her recovery process. She gave me the confidence to construct this ability of comforting patients into a small platform of confidence from which I could safely venture to educate patients or suggest treatments to residents. It could be something that I could reliably fall back on in times of doubt and something I could pass along to other people I met. © 2014 Annals of Family Medicine, Inc.
STS-98 Crew Interview: Tom Jones
2001-01-01
The STS-98 Mission Specialist Tom Jones is seen being interviewed. He answers questions about his inspiration to become an astronaut, his career path, and his training. He gives details on the mission's goals and significance, and the payload and hardware it brings to the International Space Station (ISS). Mr. Jones discusses his role in the mission's spacewalks and activities.
Argyres-Douglas Theories, the Macdonald Index, and an RG Inequality
Buican, Matthew
2015-01-01
We conjecture closed-form expressions for the Macdonald limits of the superconformal indices of the (A_1, A_{2n-3}) and (A_1, D_{2n}) Argyres-Douglas (AD) theories in terms of certain simple deformations of Macdonald polynomials. As checks of our conjectures, we demonstrate compatibility with two S-dualities, we show symmetry enhancement for special values of n, and we argue that our expressions encode a non-trivial set of renormalization group flows. Moreover, we demonstrate that, for certain values of n, our conjectures imply simple operator relations involving composites built out of the SU(2)_R currents and flavor symmetry moment maps, and we find a consistent picture in which these relations give rise to certain null states in the corresponding chiral algebras. In addition, we show that the Hall-Littlewood limits of our indices are equivalent to the corresponding Higgs branch Hilbert series. We explain this fact by considering the S^1 reductions of our theories and showing that the equivalence follows fr...
Wilson's disease (hepatolenticular degeneration).
Herron, B E
1976-01-01
Wilson's disease, or hepatolenticular degeneration, is a rare inherited disorder of copper metabolism which usually affects young people. Excess copper accumulates in the tissues, primarily in the liver, brain, and cornea. This copper deposition results in a wide range of hepatic and neurological symptoms, and may produce psychiatric illness. Hepatic involvement often occurs in childhood, while neurological deficits generally are detected at a later age. The disease is inherited in an autosomal recessive fashion. Ocular findings are of particular importance because the corneal copper deposition, forming the Kayser-Fleischer ring,is the only pathognomonic sign of the disease. The structure of the ring and the presence of copper have been well established. An anterior capsular deposition of copper in the lens results in a characteristic sunflower cataract in some of these patients. Other ocular abnormalities have been described but are much less common. The pathogenesis of the disease and the basic genetic defect remain obscure. It is clear that there is excess copper in the tissues, but the mechanism of its deposition is unknown. It is in some way associated with a failure to synthesize the serum copper protein ceruloplasmin normally. Another theory suggests that an abnormal protein with a high affinity for copper may bind the metal in the tissues. The diagnosis may be suggested by the clinical manifestations and confirmed by the presence of a Kayser-Fleischer ring. In the absence of these findings biochemical determinations are necessary. The most important of these are the serum ceruloplasmin, the urinary copper, and the hepatic copper concentration on biopsy. Treatment consists in the administration of the copper chelating agent, penicillamine, and the avoidance of a high copper intake. This usually results in marked clinical improvement if irreversible tissue damage has not occurred. Maintenance therapy for life is necessary in order to continue the negative
Women and Woodrow Wilson Fellowships.
Weiss, Nancy J.
1986-01-01
Based on a presentation made at the fortieth anniversary celebration of the Woodrow Wilson National Fellowship Foundation, considers the effect these fellowships had on the scholarly careers of the women to whom they have been awarded. (Author/ABB)
Directory of Open Access Journals (Sweden)
Mainardi Paola
2007-10-01
Full Text Available Abstract Mowat-Wilson syndrome (MWS is a multiple congenital anomaly syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows, medially flaring and sparse in the middle part, hypertelorism, deep set but large eyes, large and uplifted ear lobes, with a central depression, saddle nose with prominent rounded nasal tip, prominent columella, open mouth, with M-shaped upper lip, frequent smiling, and a prominent but narrow and triangular pointed chin, moderate-to-severe intellectual deficiency, epilepsy and variable congenital malformations including Hirschsprung disease (HSCR, genitourinary anomalies (in particular hypospadias in males, congenital heart defects, agenesis of the corpus callosum and eye anomalies. The prevalence of MWS is currently unknown, but 171 patients have been reported so far. It seems probable that MWS is under-diagnosed, particularly in patients without HSCR. MWS is caused by heterozygous mutations or deletions in the Zinc finger E-box-binding homeobox 2 gene, ZEB2, previously called ZFHX1B (SIP1. To date, over 100 deletions/mutations have been reported in patients with a typical phenotype; they are frequently whole gene deletions or truncating mutations, suggesting that haploinsufficiency is the main pathological mechanism. Studies of genotype-phenotype analysis show that facial gestalt and delayed psychomotor development are constant clinical features, while the frequent and severe congenital malformations are variable. In a small number of patients, unusual mutations can lead to an atypical phenotype. The facial phenotype is particularly important for the initial clinical diagnosis and provides the hallmark warranting ZEB2 mutational analysis, even in the absence of HSCR. The majority of MWS cases reported so far were sporadic, therefore the recurrence risk is low. Nevertheless, rare cases of sibling recurrence have been observed. Congenital malformations and seizures require
Garavelli, Livia; Mainardi, Paola Cerruti
2007-10-24
Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows, medially flaring and sparse in the middle part, hypertelorism, deep set but large eyes, large and uplifted ear lobes, with a central depression, saddle nose with prominent rounded nasal tip, prominent columella, open mouth, with M-shaped upper lip, frequent smiling, and a prominent but narrow and triangular pointed chin), moderate-to-severe intellectual deficiency, epilepsy and variable congenital malformations including Hirschsprung disease (HSCR), genitourinary anomalies (in particular hypospadias in males), congenital heart defects, agenesis of the corpus callosum and eye anomalies. The prevalence of MWS is currently unknown, but 171 patients have been reported so far. It seems probable that MWS is under-diagnosed, particularly in patients without HSCR. MWS is caused by heterozygous mutations or deletions in the Zinc finger E-box-binding homeobox 2 gene, ZEB2, previously called ZFHX1B (SIP1). To date, over 100 deletions/mutations have been reported in patients with a typical phenotype; they are frequently whole gene deletions or truncating mutations, suggesting that haploinsufficiency is the main pathological mechanism. Studies of genotype-phenotype analysis show that facial gestalt and delayed psychomotor development are constant clinical features, while the frequent and severe congenital malformations are variable. In a small number of patients, unusual mutations can lead to an atypical phenotype. The facial phenotype is particularly important for the initial clinical diagnosis and provides the hallmark warranting ZEB2 mutational analysis, even in the absence of HSCR. The majority of MWS cases reported so far were sporadic, therefore the recurrence risk is low. Nevertheless, rare cases of sibling recurrence have been observed. Congenital malformations and seizures require precocious clinical
Chiral expansion and Macdonald deformation of two-dimensional Yang-Mills theory
Kokenyesi, Zoltan; Szabo, Richard J
2016-01-01
We derive the analog of the large $N$ Gross-Taylor holomorphic string expansion for the refinement of $q$-deformed $U(N)$ Yang-Mills theory on a compact oriented Riemann surface. The derivation combines Schur-Weyl duality for quantum groups with the Etingof-Kirillov theory of generalized quantum characters which are related to Macdonald polynomials. In the unrefined limit we reproduce the chiral expansion of $q$-deformed Yang-Mills theory derived by de Haro, Ramgoolam and Torrielli. In the classical limit $q=1$, the expansion defines a new $\\beta$-deformation of Hurwitz theory wherein the refined partition function is a generating function for certain parameterized Euler characters, which reduce in the unrefined limit $\\beta=1$ to the orbifold Euler characteristics of Hurwitz spaces of holomorphic maps. We discuss the geometrical meaning of our expansions in relation to quantum spectral curves and $\\beta$-ensembles of matrix models arising in refined topological string theory.
Samuel Alexander Kinnier Wilson. Wilson's disease, Queen Square and neurology.
Broussolle, E; Trocello, J-M; Woimant, F; Lachaux, A; Quinn, N
2013-12-01
This historical article describes the life and work of the British physician Samuel Alexander Kinnier Wilson (1878-1937), who was one of the world's greatest neurologists of the first half of the 20th century. Early in his career, Wilson spent one year in Paris in 1903 where he learned from Pierre-Marie at Bicêtre Hospital. He subsequently retained uninterrupted links with French neurology. He also visited in Leipzig the German anatomist Paul Flechsig. In 1904, Wilson returned to London, where he worked for the rest of his life at the National Hospital for the Paralysed and Epileptic (later the National Hospital for Nervous Diseases, and today the National Hospital for Neurology and Neurosurgery) in Queen Square, and also at Kings' College Hospital. He wrote on 'the old motor system and the new', on disorders of motility and muscle tone, on the epilepsies, on aphasia, apraxia, tics, and pathologic laughing and crying, and most importantly on Wilson's disease. The other objective of our paper is to commemorate the centenary of Wilson's most important work published in 1912 in Brain, and also in Revue Neurologique, on an illness newly recognized and characterized by him entitled "Progressive lenticular degeneration, a familial nervous disease associated with liver cirrhosis". He analyzed 12 clinical cases, four of whom he followed himself, but also four cases previously published by others and a further two that he considered in retrospect had the same disease as he was describing. The pathological profile combined necrotic damage in the lenticular nuclei of the brain and hepatic cirrhosis. This major original work is summarized and discussed in the present paper. Wilson not only delineated what was later called hepato-lenticular degeneration and Wilson's disease, but also introduced for the first time the terms extrapyramidal syndrome and extrapyramidal system, stressing the role of the basal ganglia in motility. The present historical work emphasizes the special
Pathogenesis and management of Wilson disease.
Harada, Masaru
2014-04-01
Hepatolenticular degeneration, commonly known as Wilson disease, is an autosomal recessive inherited disease of abnormal copper metabolism, characterized by the accumulation of copper in the body due to decreased biliary excretion of copper from hepatocytes. Wilson disease protein, ATP7B, functions in copper excretion into bile and in copper secretion to the bloodstream coupled with ceruloplasmin synthesis. Various kinds of mutations of ATP7B cause Wilson disease. Wilson disease is a rare genetic disease that can be treated pharmacologically. Recognition and prompt diagnosis are very important, because Wilson disease is fatal if left untreated. In this review, I summarize the pathogenesis and management of Wilson disease.
Radial propagators and Wilson loops
Leupold, S; Leupold, Stefan; Weigert, Heribert
1996-01-01
We present a relation which connects the propagator in the radial (Fock-Schwinger) gauge with a gauge invariant Wilson loop. It is closely related to the well-known field strength formula and can be used to calculate the radial gauge propagator. The result is shown to diverge in four-dimensional space even for free fields, its singular nature is however naturally explained using the renormalization properties of Wilson loops with cusps and self-intersections. Using this observation we provide a consistent regularization scheme to facilitate loop calculations. Finally we compare our results with previous approaches to derive a propagator in Fock-Schwinger gauge.
Brillouin improvement for Wilson fermions
Durr, Stephan
2010-01-01
We present a parameter-free Wilson-type lattice Dirac operator with an 81-point stencil for the covariant derivative and the Laplacian which attempts to minimize the breaking of rotational symmetry near the boundary of the Brillouin zone. The usefulness of this "Brillouin operator" in practical applications is explored by studying the scaling of pseudoscalar decay constants in quenched QCD, with rather good results in the physical charm region. We also investigate the suitability of this operator as a kernel to the overlap procedure. Here, the resulting overlap operator is found to be cheaper to construct and significantly better localized than the variety with the standard Wilson kernel.
2012-07-16
... determination was published in the Federal Register on February 8, 2012 (77 FR 6590). At the request of a... Employment and Training Administration Dow Jones & Company, Inc., Dow Jones Content Services Division... January 26, 2011, applicable to workers of Dow Jones & Company, Inc., Dow Jones Content Services...
2012-04-02
... Federal Register on February 8, 2012 (77 FR 6590). At the request of the New Jersey State agency, the... Employment and Training Administration Dow Jones & Company, Inc., Dow Jones Content Services Including On... at Dow Jones Corporation, Dow Jones Content Services Princeton, New Jersey. The workers are engaged...
Befriending Askey-Wilson polynomials
Szabłowski, Paweł J
2011-01-01
Although our main interest is with the Askey-Wilson (AW) polynomials we recall and review four other families of the so-called Askey-Wilson scheme of polynomials. We do this for completeness as well as for better exposition of AW properties. Our main results concentrate on the complex parameters case, revealing new fascinating symmetries between the variables and some of the parameters. In particular we express Askey-Wilson polynomials as linear combinations of Al-Salam--Chihara (ASC) polynomials which together with the obtained earlier expansion of the Askey-Wilson density forms complete generalization of the situation met in the case of Al-Salam--Chihara and q-Hermite polynomials and the Poisson-Mehler expansion formula. As a by-product we get useful identities involving ASC polynomials. Finally by certain re-scaling of variables and parameters we arrive to AW polynomials and AW densities that have clear probabilistic interpretation. We recall some known and present some believed to be unknown identities an...
Population screening for Wilson's disease.
Hahn, Si Houn
2014-05-01
Wilson's disease is an autosomal recessive disorder of copper transport caused by mutations in the gene encoding an ATPase, ATP7B. Early detection of Wilson's disease is critical because effective medical treatments such as chelating agents and zinc salts are available, which can prevent lifelong neurological disabilities and/or cirrhosis. It is unfortunate that most patients are brought to our attention after they have developed serious complications such as brain damage or cirrhosis, despite the availability of effective treatments. The diagnosis is usually made through copper measurement in the liver tissue, followed by confirmation with genetic testing of the ATP7B gene. Currently, there are no effective biomarkers or methods suitable for newborn screening for Wilson's disease. Ceruloplasmin has been tested for pediatric and newborn screening with limited outcome. Recently, liquid chromatography-multiple reaction monitoring-mass spectrometry (LC-MRM-MS) has emerged as a robust technology that may enable multiplex quantification of signature proteotypic peptides with low abundance. The application of this technology may help facilitate the research on Wilson's disease for protein expression, biomarker study, diagnosis, and, hopefully, screening.
How Is Wilson Disease Inherited?
... nationalities has the disease. Of the 23 different human chromosomes, the gene responsible for Wilson disease is located on chromosome 13. The gene is called ATP7B and it contains the genetic information necessary to make a copper transport protein that plays a key role in incorporating copper ...
Ken Wilson: Solving the Strong Interactions
Peskin, Michael E
2014-01-01
Ken Wilson's ideas on the renormalization group were shaped by his attempts to build a theory of the strong interactions based on the concepts of quantum field theory. I describe the development of his ideas by reviewing four of Wilson's most important papers. [contribution to the Journal of Statistical Physics Special Issue in Memory of K. G. Wilson
Cerebral imaging for Wilson disease; Zerebrale Bildgebung bei Morbus Wilson
Energy Technology Data Exchange (ETDEWEB)
Andersen, K.; Saleh, A. [Universitaetsklinikum Duesseldorf (Germany). Inst. fuer Diagnostische Radiologie; Suedmeyer, M. [Universitaetsklinikum Duesseldorf (Germany). Klinik fuer Neurologie
2007-03-15
Wilson disease is an autosomal recessive inherited copper metabolic disorder that is characterized by diminished biliary excretion of copper and a raised serum level of free copper. This leads to a toxic copper accumulation, particularly in the liver and the brain. Therefore, clinical symptoms are dominated by hepatic and extrapyramidal symptoms. Untreated Wilson disease has an unfavorable outcome. Cerebral changes are depicted most sensitively by magnetic resonance tomography. Pathological findings mainly focus on the basal ganglia, the midbrain and the brainstem. Depending on the therapy and the severity of the neurological symptoms, signal increase as well as signal decrease may be observed in T1-weighted (T1w) and T2-weighted (T2w) images and can be reversible when using an appropriate therapy. Hyperintense areas in T2-weighted images are induced by edema, gliosis, demyelinisation or cystic degeneration. Signal increase in T1-weighted images are found in patients with hepatic insufficiency and are probably due to manganese deposits. Signal decrease in T2-weighted images is probably caused by the paramagnetic effect of the copper accumulation. Furthermore, recent studies show a correlation between the clinical severity and changes in diffusion-weighted sequences. Although cross-section imaging plays a rather subordinate role in the primary diagnostics of Wilson disease, the described cerebral changes in patients with extrapyramidal disturbances should include Wilson disease in the differential. Persistent or progressive hyperintense lesions in T2-weighted images reflect therapy failure, and clinical recovery correlates to an improvement in MR images. Therefore, repeat MR imaging can be used to monitor medical therapy.
Chiral expansion and Macdonald deformation of two-dimensional Yang-Mills theory
Energy Technology Data Exchange (ETDEWEB)
Koekenyesi, Zoltan; Sinkovics, Annamaria [Institute of Theoretical Physics, MTA-ELTE Theoretical Research Group, Eoetvoes Lorand University, 1117, Budapest, Pazmany, s. 1/A (Hungary); Szabo, Richard J. [Heriot-Watt Univ., Edinburgh (United Kingdom). Dept. of Mathematics; Maxwell Institute for Mathematical Sciences, Edinburgh (United Kingdom); The Higgs Centre for Theoretical Physics, Edinburgh (United Kingdom)
2016-11-15
We derive the analog of the large N Gross-Taylor holomorphic string expansion for the refinement of q-deformed U(N) Yang-Mills theory on a compact oriented Riemann surface. The derivation combines Schur-Weyl duality for quantum groups with the Etingof-Kirillov theory of generalized quantum characters which are related to Macdonald polynomials. In the unrefined limit we reproduce the chiral expansion of q-deformed Yang-Mills theory derived by de Haro, Ramgoolam and Torrielli. In the classical limit q = 1, the expansion defines a new β-deformation of Hurwitz theory wherein the refined partition function is a generating function for certain parameterized Euler characters, which reduce in the unrefined limit β = 1 to the orbifold Euler characteristics of Hurwitz spaces of holomorphic maps. We discuss the geometrical meaning of our expansions in relation to quantum spectral curves and β-ensembles of matrix models arising in refined topological string theory. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)
Interplay between MacDonald and Hall-Littlewood expansions of extended torus superpolynomials
Mironov, A; Shakirov, Sh; Sleptsov, A
2012-01-01
In arXiv:1106.4305 extended superpolynomials were introduced for the torus links T[m,mk+r], which are functions on the entire space of time variables and, at expense of reducing the topological invariance, possess additional algebraic properties, resembling those of the matrix model partition functions and the KP/Toda tau-functions. Not surprisingly, being a suitable extension it actually allows one to calculate the superpolynomials. These functions are defined as expansions into MacDonald polynomials, and their dependence on k is entirely captured by the action of the cut-and-join operator, like in the HOMFLY case. We suggest a simple description of the coefficients in these character expansions, by expanding the initial (at k=0) conditions for the k-evolution into the new auxiliary basis, this time provided by the Hall-Littlewood polynomials, which, hence, play a role in the description of the dual m-evolution. For illustration we list manifest expressions for a few first series, mk\\pm 1, mk\\pm 2, mk\\pm 3. ...
Generalized Jones matrices for anisotropic media.
Ortega-Quijano, Noé; Arce-Diego, José Luis
2013-03-25
The interaction of arbitrary three-dimensional light beams with optical elements is described by the generalized Jones calculus, which has been formally proposed recently [Azzam, J. Opt. Soc. Am. A 28, 2279 (2011)]. In this work we obtain the parametric expression of the 3×3 differential generalized Jones matrix (dGJM) for arbitrary optical media assuming transverse light waves. The dGJM is intimately connected to the Gell-Mann matrices, and we show that it provides a versatile method for obtaining the macroscopic GJM of media with either sequential or simultaneous anisotropic effects. Explicit parametric expressions of the GJM for some relevant optical elements are provided.
Wilson's Disease Presenting With Pancytopenia
Acıpayam, Can; Altunay, Ali; Nilüfer İLHAN; Atçı, Nesrin
2015-01-01
Wilson’s disease is an autosomal recessive disorder of copper metabolism characterized by excessive amount of copper in liver, brain, eye and other body tissues. Diagnosis is based on the presence of Kayser-Fleischer rings, typical neurological symptoms, and/or a low serum ceruloplasmin concentration. The main clinical symptoms are usually due to hepatic and/or neurologic involvement. Pancytopenia is a rare initial symptom of Wilson Disease. An 11-year-old female presented with pancytopenia. ...
Continuous smearing of Wilson Loops
Lohmayer, Robert
2011-01-01
Continuum smearing was introduced in section 4.1 of JHEP03, 064 (2006) as a meaningful continuum analogue of the well known set of lattice techniques by the same name. Here we apply continuous smearing in continuous space-time to Wilson loops in order to clarify what it does in the context of field theory and also in the context of the loop calculus of the Makeenko-Migdal equation.
Wilson's disease: An endocrine revelation
Kapoor, Nitin; Shetty, Sahana; Thomas, Nihal; Paul, Thomas Vizhalil
2014-01-01
Wilson's disease is an inherited disorder of copper metabolism. The affected patients, who otherwise have a near normal life span, may often suffer from some potentially treatable and under recognized endocrine disorders that may hinder their quality of life. We explored previously published literature on the various endocrine aspects of this disease with their probable underlying mechanisms, highlighting the universal need of research in this area. PMID:25364683
[Wilson's disease - a case report].
Karwowska, Kornelia; Skrzypek, Julita; Chabik, Grzegorz; Członkowska, Anna; Zaborowska, Marzena; Wawrzyniak, Sławomir
2016-01-01
Wilson's disease (WD) or hepatolenticular degeneration, is a rare autosomal recessive genetic disorder caused by mutations in the Wilson disease protein (ATP7B) gene. It is characterized by impaired copper metabolism leading to its accumulation in various tissues and organs, including the liver and central nervous system, this results in the development of characteristic liver disease and neuropsychiatric symptoms. Liver symptoms usually appear during first three decades of life, while psychiatric symptoms are observed in people who are in their twenties or older. WD is one of few genetic diseases that can be effectively treated with pharmacotherapy. However, some cases, especially diagnosed late in the course of the disease, may not respond well to treatment. Here we present a case of a 22-year-old male with neurological, psychiatric and liver disease symptoms as an example of diagnostic and therapeutic challenges in patients. Wilson's disease (WD) should be considered in all patients presenting with neurological, psychiatric and liver disease symptoms especially those of young age.
Haplotype studies in Wilson disease
Energy Technology Data Exchange (ETDEWEB)
Thomas, G.R.; Bull, P.C.; Roberts, E.A.; Cox, D.W.; Walshe, J.M. (Univ. of Toronto (Canada))
1994-01-01
In 51 families with Wilson disease, the authors have studied DNA haplotypes of dinucleotide repeat polymorphisms (CA repeats) in the 13q14.3 region, to examine these markers for association with the Wilson disease gene (WND). In addition to a marker (D13S133) described elsewhere, the authors have developed three new highly polymorphic markers (D13S314, D13S315, and D13S316) close to the WND locus. The authors have examined the distribution of marker alleles at the loci studied and have found that D13S314, D13S133, and D13S316 each show nonrandom distribution on chromosomes carrying the WND mutation. The authors have studied haplotypes of these three markers and have found that there are highly significant differences between WND and normal haplotypes in northern European families. These findings have important implications for mutation detection and molecular diagnosis in families with Wilson disease. 25 refs., 2 figs., 5 tabs.
Dow Jones tugevdab oma koostist / Virge Lahe
Lahe, Virge
2008-01-01
USA tööstusettevõtteid koondav indeks Dow Jones vahetab nimekirjast välja kaks firmat ning lisab finants- ja kütusesektori osakaalu suurendamiseks Bank of America ja Chevroni. Vt. samas: Dow Jonesi tööstuskeskmisse lisandumine pole aktsiatele tiibu andnud; Dow Jonesi tööstuskeskmine
Dow Jones tugevdab oma koostist / Virge Lahe
Lahe, Virge
2008-01-01
USA tööstusettevõtteid koondav indeks Dow Jones vahetab nimekirjast välja kaks firmat ning lisab finants- ja kütusesektori osakaalu suurendamiseks Bank of America ja Chevroni. Vt. samas: Dow Jonesi tööstuskeskmisse lisandumine pole aktsiatele tiibu andnud; Dow Jonesi tööstuskeskmine
Dow Jones News/Retrieval--An IndepthBxook.
Dempsey, Tim
1984-01-01
This introduction to the nonbibliographic databases offered by the Dow Jones News/Retrieval Service describes file content and search strategies in four groups: Dow Jones Business and Economic News; Dow Jones Quotes (market prices for stocks and other securities); Financial and Investment Services; General News and Information Services. Examples…
Catatonia: an unusual manifestation of Wilson's disease.
Basu, Aniruddha; Thanapal, Sivakumar; Sood, Mamta; Khandelwal, Sudhir K
2015-01-01
Wilson's disease, characterized by abnormal copper accumulation in the human body, may present with psychiatric manifestations in about one-fifth of patients. The authors report a patient with Wilson's disease who initially presented with acute psychosis and later developed catatonic symptoms. The atypical presentation led to a delay in diagnosis and institution of appropriate treatment. Wilson's disease can be ruled out in all young patients presenting with psychiatric symptoms for the first time by screening for a Kayser-Fleischer ring.
Cholestatic liver disease masquerading as Wilson disease.
Sood, Vikrant; Rawat, Dinesh; Khanna, Rajeev; Alam, Seema
2015-03-01
Wilson disease and cholestatic liver diseases may present as a diagnostic dilemma if standard guidelines incorporating markers of copper overload are followed. We hereby present a series of four cases of sclerosing cholangitis masquerading as Wilson disease. True Wilson disease cases had significantly lower ceruloplasmin (6 vs. 16 mg/dL) and higher 24-hour urinary copper (322.3 vs. 74.5 μg/day) as compared to mimickers. Initial low serum ceruloplasmin levels normalized in mimickers on follow up, and this may used as a diagnostic indicator. Standard Wilson disease diagnostic criteria thus need further modification especially in developing countries to help avoid mismanagement.
Institute of Scientific and Technical Information of China (English)
许炽华; 沈时霖
1989-01-01
@@ Wilson-Mikity综合征(简称WMS),是发生在极低体重儿的一种慢性呼吸困难疾病.1960年首次由美国的Wilson和Mikity所报道,后为世界各国公认,并以此命名[1～3].本病为一种独立疾病,长期来病因不明,近年来日本有较多的研究并证明与胎儿宫内感染有关[2～4].
2013-08-13
... Employment and Training Administration Dow Jones & Company, Inc., Dow Jones Content Services Division, Including a Worker of Factiva, Inc., A Subsidiary of Dow Jones Coporation and On-Site Leased Workers From... Assistance on January 26, 2012, applicable to workers of Aerotek, Inc., working on-site at Dow...
Directory of Open Access Journals (Sweden)
I. A. Shilin
2014-01-01
Full Text Available Computing the matrix elements of the linear operator, which transforms the spherical basis of SO(3,1-representation space into the hyperbolic basis, very recently, Shilin and Choi (2013 presented an integral formula involving the product of two Legendre functions of the first kind expressed in terms of 4F3-hypergeometric function and, using the general Mehler-Fock transform, another integral formula for the Legendre function of the first kind. In the sequel, we investigate the pairwise connections between the spherical, hyperbolic, and parabolic bases. Using the above connections, we give an interesting series involving the Gauss hypergeometric functions expressed in terms of the Macdonald function.
Jimbo, M; Konno, H; Miwa, T; Petersen, J U H
1995-01-01
The level-1 integrable highest weight modules of U_q(\\widehat{sl}_2) admit a level-0 action of the same algebra. This action is defined using the affine Hecke algebra and the basis of the level-1 module generated by components of vertex operators. Each level-1 module is a direct sum of finite-dimensional irreducible level-0 modules, whose highest weight vector is expressed in terms of Macdonald polynomials. This decomposition leads to the fermionic character formula for the level-1 modules.
Wilson lines in quantum field theory
Cherednikov, Igor O; Veken, Frederik F van der
2014-01-01
The objective of this book is to get the reader acquainted with theoretical and mathematical foundations of the concept of Wilson loops in the context of modern quantum field theory. It teaches how to perform independently with some elementary calculations on Wilson lines, and shows the recent development of the subject in different important areas of research.
Wade Wilson Controls NFL Defenses, Diabetes.
Thompson, K
1989-12-01
When Minnesota Vikings quarterback Wade Wilson was diagnosed with diabetes just days before the 1985 season, he scrambled to learn how to manage the disease. With his health-and perhaps his career-hanging in the balance, Wilson deftly made the life-style changes necessary to continue play.
LATTICE QCD THERMODYNAMICS WITH WILSON QUARKS.
Energy Technology Data Exchange (ETDEWEB)
EJIRI,S.
2007-11-20
We review studies of QCD thermodynamics by lattice QCD simulations with dynamical Wilson quarks. After explaining the basic properties of QCD with Wilson quarks at finite temperature including the phase structure and the scaling properties around the chiral phase transition, we discuss the critical temperature, the equation of state and heavy-quark free energies.
The Fading Legacy of Woodrow Wilson.
Martin, Daniel W.
1988-01-01
Reexamines Woodrow Wilson's contribution to public administration and arrives at four conclusions: (1) the study of public administration was developed in Europe; (2) Wilson's politics/administration dichotomy was different than the European model; (3) his dichotomy was based on an incorrect translation and abandoned; and (4) his dichotomy was…
Wilson's disease; increased aluminum in liver.
Yasui, M; Yoshimasu, F; Yase, Y; Uebayashi, Y
1979-01-01
Interaction of trace metal metabolism was studied in a patient with Wilson's dease. Atomic absorption analysis showed markedly increased urinary excretion of copper and aluminum and an increased aluminum content was found in the biopsied liver by neutron activation analysis. These findings suggest a complicated pathogenetic mechanism involving other metals besides copper in the Wilson's disease.
The link between copper and Wilson's disease.
Purchase, Rupert
2013-01-01
Wilson's disease (hepatolenticular degeneration) is a rare inherited autosomal recessive disorder of copper metabolism leading to copper accumulation in the liver and extrahepatic organs such as the brain and cornea. Patients may present with combinations of hepatic, neurological and psychiatric symptoms. Copper is the therapeutic target for the treatment of Wilson's disease. But how did copper come to be linked with Wilson's disease? The answer encompasses a study of enzootic neonatal ataxia in lambs in the 1930s, the copper-chelating properties of British Anti-Lewisite, and the chemical analysis for copper of the organs of deceased Wilson's disease patients in the mid-to-late 1940s. Wilson's disease is one of a number of copper-related disorders where loss of copper homeostasis as a result of genetic, nutritional or environmental factors affects human health.
Liver transplantation for Wilson's disease.
Schilsky, Michael L
2014-05-01
Although Wilsons's disease (WD) may be treated with copper chelation (to remove copper) or zinc salts (to prevent absorption) to alleviate or prevent symptom development in most patients, there are WD patients for whom medical therapy is inadequate and survival would be unlikely without liver transplantation. Liver transplantation is indicated for the ∼5% of WD patients with acute liver failure as the first presentation of disease, most commonly in the second decade of life, or those who present with end-stage liver disease and severe hepatic insufficiency, most commonly in the third and fourth decades. Liver transplantation restores normal biliary copper excretion (thereby preventing disease recurrence) and promotes removal of copper from extrahepatic sites. Outcomes of liver transplantation for WD are excellent, including both cadaveric and living donors.
Wilson loops with arbitrary charges
Korcyl, Piotr; Wosiek, Jacek
2014-01-01
We discuss how to implement, in lattice gauge theories, external charges which are not commensurate with an elementary gauge coupling. It is shown that an arbitrary, real power of a standard Wilson loop (or Polyakov line) can be defined and consistently computed in lattice formulation of non-abelian, two dimensional gauge theories. However, such an observable can excite quantum states with integer fluxes only. Since the non-integer fluxes are not in the spectrum of the theory they cannot be created, no matter which observable is chosen. Also the continuum limit of above averages does not exist unless the powers in question are in fact integer. On the other hand, a new continuum limit exists, which is rather intuitive, and where above observables make perfect sense and lead to the string tension proportional to the square of arbitrary (non necessary commensurate with gauge coupling) charge.
Institute of Scientific and Technical Information of China (English)
陈煐光
2002-01-01
@@ 在为数不多的英国高级音箱厂家之中,Wilson Benesch是最富创新意念和最讲究校声技艺的一家.厂方将碳纤这种物质运用在Hi-Fi器材之中得到很大的成功.他们用碳纤混合素材来制造的盘臂头组合Act 1+Act 2被誉为世上最靓声的LP唱片重播组合之一,而用碳纤制作部分声箱的处女作Act One更在数年前面世之后轰动音响界,其真实无匹的小提琴声和无穷尽的音乐感赢得不少高级音响玩家的钟爱.
Kenneth Wilson and lattice QCD
Ukawa, Akira
2015-01-01
We discuss the physics and computation of lattice QCD, a space-time lattice formulation of quantum chromodynamics, and Kenneth Wilson's seminal role in its development. We start with the fundamental issue of confinement of quarks in the theory of the strong interactions, and discuss how lattice QCD provides a framework for understanding this phenomenon. A conceptual issue with lattice QCD is a conflict of space-time lattice with chiral symmetry of quarks. We discuss how this problem is resolved. Since lattice QCD is a non-linear quantum dynamical system with infinite degrees of freedom, quantities which are analytically calculable are limited. On the other hand, it provides an ideal case of massively parallel numerical computations. We review the long and distinguished history of parallel-architecture supercomputers designed and built for lattice QCD. We discuss algorithmic developments, in particular the difficulties posed by the fermionic nature of quarks, and their resolution. The triad of efforts toward b...
Monitoring copper in Wilson's disease.
Walshe, J M
2010-01-01
Monitoring copper metabolism in patients with Wilson's disease is not an exact science. At present, there are no simple methods of estimating the total body load of this metal. Indirect methods must therefore be used. A survey of the current literature shows that most approaches rely on the determination of blood and urine copper concentration. Both these should decrease with treatment. In parallel with decreased copper concentration, there should be subsequent improvement in more routine laboratory tests including liver and renal function, blood count parameters, and clotting factors. Lack of compliance is revealed by a reversal of this trend. This chapter critically reviews current testing methods and describes other approaches that may be helpful.
Cognitive impairment in Wilson's disease
Directory of Open Access Journals (Sweden)
Norberto Anizio Ferreira Frota
Full Text Available Abstract Wilson's disease (WD or hepatolenticular degeneration is a rare, genetic and systemic disease, caused by a deficit in the metabolism of copper, leading to its accumulation in different organs, mainly the liver, followed by the central nervous system, especially the basal ganglia. When symptoms begin between the second and third decades of life, approximately 50% of the patients show neurological symptoms. Although dystonia and dysarthria are the most common neurological signs, cognitive changes have been reported since the first cases were described in 1912. Memory change is one of the most common impairments, but other cognitive changes have been reported, including dementia in untreated cases. In this article we review the cognitive changes in WD patients and the occurrence of dementia.
Wilson's disease and other neurological copper disorders.
Bandmann, Oliver; Weiss, Karl Heinz; Kaler, Stephen G
2015-01-01
The copper metabolism disorder Wilson's disease was first defined in 1912. Wilson's disease can present with hepatic and neurological deficits, including dystonia and parkinsonism. Early-onset presentations in infancy and late-onset manifestations in adults older than 70 years of age are now well recognised. Direct genetic testing for ATP7B mutations are increasingly available to confirm the clinical diagnosis of Wilson's disease, and results from biochemical and genetic prevalence studies suggest that Wilson's disease might be much more common than previously estimated. Early diagnosis of Wilson's disease is crucial to ensure that patients can be started on adequate treatment, but uncertainty remains about the best possible choice of medication. Furthermore, Wilson's disease needs to be differentiated from other conditions that also present clinically with hepatolenticular degeneration or share biochemical abnormalities with Wilson's disease, such as reduced serum ceruloplasmin concentrations. Disordered copper metabolism is also associated with other neurological conditions, including a subtype of axonal neuropathy due to ATP7A mutations and the late-onset neurodegenerative disorders Alzheimer's disease and Parkinson's disease.
Jones matrices of perfectly conducting metallic polarizers
Boyer, Philippe
2014-01-01
We deduce from Monomode Modal Method the analytical expressions of transmission and reflexion Jones matrices of an infinitely conducting metallic screen periodically pierced by subwavelength holes. The study is restricted to normal incidence and to the case of neglected evanescent fields (far-field) which covers many common cases. When only one non-degenerate mode propagates in cavities, they take identical forms to those of a polarizer, with Fabry-Perot-like spectral resonant factors depending on bigrating parameters. The isotropic or birefringent properties are then obtained when holes support two orthogonal polarization modes. This basic formalism is finally applied to design compact and efficient metallic half-wave plates.
Walter Laing Macdonald Perry KT OBE, Barron Perry of Walton, 21 June 1921 - 17 July 2003.
Kelly, John S; Horlock, John H
2004-01-01
Lord Perry of Walton died suddenly on 17 July 2003, at the age of 82 years. Walter Laing Macdonald Perry was a native of Dundee, educated at Morgan Academy Dundee, Ayr Academy, Dundee High School and St Andrews University (MB ChB, MD and DSc), winning the Rutherford Silver Medal for his MD thesis and the Sykes Gold Medal for his DSc thesis. After Casaulty Officer and House Surgeon posts in 1943-44, he served as a Medical Officer in the Colonial Medical Service in Nigeria in 1944-46, then briefly as a Medical Officer in the RAF, 1946-47, before embarking on a scientific career on the staff of the Medical Research COuncil at the National Institute for Medical Research from 1947 to 1958, serving as Director of the Department of Biological Standards from 1952 to 1958. Professionally, he achieved MRCP (ED) in 1963 and was elected FRCPE in 1967, FRCP in 1978, FRSE in 1960 and FRS in 1985. In 1958 he came to Edinburgh as Professor of Pharmacology, holding the Chair from 1958 to 1968. During this time he also served as Dean of the Faculty of Medicine (1965-67) and Vice-Principal of the University (1967-68) before leaving to become the inaugural Vice-Chancellor of the Open University in 1968, a post he held until 1980. During this period at the Open University he developed a second distinguish career as a university administrator and a promotor and facilitator of open and distance learning, in which fields he later performed extensive work on behalf of the United Nations. A third career, in politics and public life, began with his ennoblement to a life peerage in 1979, taking the title of Walton in the County of Buckinghamshire, the initial base of the Open University. Latterly Walter sat as a Liberal Democrat, having twice been Social Democratic Party deputy leader in the Lords in the 1980s. He took an active role in the Lords' Select Committee on Science and Technology and held interests in and spoke on many areas of public policy, including fisheries policy. Recognition
Sunflower cataract: do not forget Wilson's disease.
Litwin, Tomasz; Langwińska-Wośko, Ewa; Dzieżyc, Karolina; Członkowska, Anna
2015-10-01
A 41-year-old man with liver cirrhosis of unknown aetiology for 6 years was admitted to our department to confirm the diagnosis of Wilson's disease. He consulted an ophthalmologist who suspected the presence of a sunflower cataract and Kayser-Fleischer ring. At admission, his liver function tests were modestly impaired (Child-Pugh C, 10 pts). Neurological examination was normal, but cognitive functions were mildly impaired. Based on the copper metabolism abnormalities and clinical manifestation, we diagnosed Wilson's disease (Ferenci score, 6 pts) and started treatment with d-penicillamine. Presenting the case we would like to emphasise the significance of the ophthalmological examination in Wilson's disease diagnosis.
Wilson Loop Form Factors: A New Duality
Chicherin, Dmitry; Heslop, Paul; Korchemsky, Gregory P.; Sokatchev, Emery
2016-01-01
We find a new duality for form factors of lightlike Wilson loops in planar $\\mathcal N=4$ super-Yang-Mills theory. The duality maps a form factor involving an $n$-sided lightlike polygonal super-Wilson loop together with $m$ external on-shell states, to the same type of object but with the edges of the Wilson loop and the external states swapping roles. This relation can essentially be seen graphically in Lorentz harmonic chiral (LHC) superspace where it is equivalent to planar graph duality....
Renormalization of Wilson operators in Minkowski space
Andra, A
1996-01-01
We make some comments on the renormalization of Wilson operators (not just vacuum -expectation values of Wilson operators), and the features which arise in Minkowski space. If the Wilson loop contains a straight light-like segment, charge renormalization does not work in a simple graph-by-graph way; but does work when certain graphs are added together. We also verify that, in a simple example of a smooth loop in Minkowski space, the existence of pairs of points which are light-like separated does not cause any extra divergences.
Zeros of Jones polynomials for families of knots and links
Chang, S.-C.; Shrock, R.
2001-12-01
We calculate Jones polynomials VL( t) for several families of alternating knots and links by computing the Tutte polynomials T( G, x, y) for the associated graphs G and then obtaining VL( t) as a special case of the Tutte polynomial. For each of these families we determine the zeros of the Jones polynomial, including the accumulation set in the limit of infinitely many crossings. A discussion is also given of the calculation of Jones polynomials for non-alternating links.
Product Integral Representations of Wilson Lines and Wilson Loops, and Non-Abelian Stokes Theorem
Karp, R L; Rno, J S
2000-01-01
We make use of product integrals to provide an unambiguous mathematical representation of Wilson line and Wilson loop operators. Then, drawing upon various properties of product integrals, we discuss such properties of these operators as approximating them with partial sums, their convergence, and their behavior under gauge transformations. We also obtain a surface product integral representation for the Wilson loop operator. The result can be interpreted as the non-abelian version of Stokes theorem.
Neuroimaging findings in Mowat-Wilson syndrome
DEFF Research Database (Denmark)
Garavelli, Livia; Ivanovski, Ivan; Caraffi, Stefano Giuseppe
2017-01-01
PURPOSE: Mowat-Wilson syndrome (MWS) is a genetic disease characterized by distinctive facial features, moderate to severe intellectual disability, and congenital malformations, including Hirschsprung disease, genital and eye anomalies, and congenital heart defects, caused by haploinsufficiency o...
Neuroimaging findings in Mowat-Wilson syndrome
DEFF Research Database (Denmark)
Garavelli, Livia; Ivanovski, Ivan; Caraffi, Stefano Giuseppe
2016-01-01
PURPOSE: Mowat-Wilson syndrome (MWS) is a genetic disease characterized by distinctive facial features, moderate to severe intellectual disability, and congenital malformations, including Hirschsprung disease, genital and eye anomalies, and congenital heart defects, caused by haploinsufficiency o...
Cusped Wilson lines in symmetric representations
Correa, Diego H; Trancanelli, Diego
2015-01-01
We study the cusped Wilson line operators and Bremsstrahlung functions associated to particles transforming in the rank-$k$ symmetric representation of the gauge group $U(N)$ for ${\\cal N} = 4$ super Yang-Mills. We find the holographic D3-brane description for Wilson loops with internal cusps in two different limits: small cusp angle and $k\\sqrt{\\lambda}\\gg N$. This allows for a non-trivial check of a conjectured relation between the Bremsstrahlung function and the expectation value of the 1/2 BPS circular loop in the case of a representation other than the fundamental. Moreover, we observe that in the limit of $k\\gg N$, the cusped Wilson line expectation value is simply given by the exponential of the 1-loop diagram. Using group theory arguments, this eikonal exponentiation is conjectured to take place for all Wilson loop operators in symmetric representations with large $k$, independently of the contour on which they are supported.
Genetics Home Reference: Mowat-Wilson syndrome
... Diseases Health Topic: Congenital Heart Defects Health Topic: Developmental Disabilities Genetic and Rare Diseases Information Center (1 link) Mowat-Wilson syndrome Additional NIH Resources (2 ... Intellectual and Developmental Disabilities National Institute of Diabetes and Digestive and ...
Wilson Loops in Open String Theory
Shiraishi, Kiyoshi
Wilson loop elements on torus are introduced into the partition function of open strings as Polyakov’s path integral at one-loop level. Mass spectra from compactification and expected symmetry breaking are illustrated by choosing the correct weight for the contributions from annulus and Möbius strip. We show that Jacobi’s imaginary transformation connects the mass spectra with the Wilson loops. The application to thermopartition function and cosmological implications are briefly discussed.
Wilson Loops in Open String Theory
Shiraishi, Kiyoshi
2012-01-01
Wilson loop elements on torus are introduced into the partition function of open strings as Polyakov's path integral at one-loop level. Mass spectra from compactification and expected symmetry breaking are illustrated by choosing the correct weight for the contributions from annulus and M\\"obius strip. We show that Jacobi's imaginary transformation connects the mass spectra with the Wilson loops. The application to thermopartition function and cosmological implications are briefly discussed.
Zero Point Energy of Renormalized Wilson Loops
Hidaka, Yoshimasa; Pisarski, Robert D.
2009-01-01
The quark antiquark potential, and its associated zero point energy, can be extracted from lattice measurements of the Wilson loop. We discuss a unique prescription to renormalize the Wilson loop, for which the perturbative contribution to the zero point energy vanishes identically. A zero point energy can arise nonperturbatively, which we illustrate by considering effective string models. The nonperturbative contribution to the zero point energy vanishes in the Nambu model, but is nonzero wh...
Master Symmetry for Holographic Wilson Loops
Klose, Thomas; Munkler, Hagen
2016-01-01
We identify the symmetry underlying the recently observed spectral-parameter transformations of holographic Wilson loops alias minimal surfaces in AdS/CFT. The generator of this nonlocal symmetry is shown to furnish a raising operator on the classical Yangian-type charges of symmetric coset models. We explicitly demonstrate how this master symmetry acts on strong-coupling Wilson loops and indicate a possible extension to arbitrary coupling.
Wilson loops in CDT quantum gravity
Ambjorn, J; Jurkiewicz, J; Loll, R
2015-01-01
By explicit construction, we show that one can in a simple way introduce and measure gravitational holonomies and Wilson loops in lattice formulations of nonperturbative quantum gravity based on (Causal) Dynamical Triangulations. We use this set-up to investigate a class of Wilson line observables associated with the world line of a point particle coupled to quantum gravity, and deduce from their expectation values that the underlying holonomies cover the group manifold of SO(4) uniformly
Sextet Model with Wilson Fermions
Hansen, Martin
2016-01-01
We present new results from our ongoing study of the SU(3) sextet model with two flavors in the two-index symmetric representation of the gauge group. In the simulations use unimproved Wilson fermions to investigate the infrared properties of the model. We have previously presented results for the spectrum of the model in the weak coupling regime. Here, to better understand the overall behavior of the lattice model, we map its non-trivial phase structure in the space of bare parameters. At strong coupling, we observe a first order phase transition when decreasing the bare quark mass. This first order transition weakens when moving towards weaker couplings with an endpoint at a finite value of the bare coupling, after which it appears to be a continuous transition. We also investigate the behavior of the mass spectrum and scale-setting observable, as a function of the quark mass, and show that their qualitative behavior change significantly when moving from the strong coupling into the weak coupling phase.
Chemical Potential of a Lennard Jones Fluid
Celebonovic, V.
2010-12-01
The aim of this paper is to present results of analytical calculation of chemical potential of a Lennard Jones (LJ) fluid performed in two ways: by using the thermodynamical formalism and the formalism of statistical mechanics. The integration range is divided into two regions. In the small distance region, which is r≤σ in the usual notation, the integration range had to be cut off in order to avoid the occurence of divergences. In the large distance region, the calculation is technically simpler. The calculation reported here will be useful in all kinds of studies concerning phase equilibrium in a LJ fluid. Interesting kinds of such systems are the giant planets and the icy satellites in various planetary systems, but also the (so far) hypothetical quark stars.
Robert T. Jones, One of a Kind
Vincenti, Walter G.
2005-01-01
His contemporaries saw R.T. Jones as one of the notably creative aerodynamicists of the twentieth century. This essay reviews his remarkable life and career, including his years as a farm-country boy, college dropout, and fledgling airplane designer in Missouri, his time as an elevator operator and self-directed student in Washington, D.C., and his long professional career as an aerodynamicist at the Langley and Ames Aeronautical Laboratories and Stanford University. The focus in his career is on his fundamental discovery of the benefits of sweepback for the wings of high-speed airplanes. This includes speculation about his highly intuitive thought processes in arriving at his creative ideas. I also give an account of his work on blood flow and the mechanical heart, his avocational accomplishments as a maker of telescopes and violins, and his philosophical interest in human affairs.
Obituary: Frank Culver Jones, 1932-2007
Ormes, Johnathan F.; Streitmatter, Robert E.
2007-12-01
Frank C. Jones, an emeritus theoretical physicist at NASA, died May 2, 2007 at age 74 after a struggle with a rare form of cancer. He died at his home in Silver Spring, Maryland, surrounded by his family. Frank was born July 30, 1932 in Fort Worth, Texas, the oldest of three boys. His parents were Kenneth Hugh and Nancy Culver Jones. Frank's father was a lawyer, and his grandfather was a Methodist minister. Frank graduated from Rice University in 1954 and earned a master's degree in 1955 and a doctorate in 1961, both in physics, from the University of Chicago. He did his graduate work with Prof. John Simpson. Dr. Jones began his professional career as an instructor in physics at Princeton University before joining NASA's Goddard Space Flight Center in 1963 as a National Research Council associate. He subsequently became a member of the Theory Division and the Laboratory for High Energy Astrophysics. His area of expertise was the origin, transport, and electromagnetic interactions of cosmic rays. His particular focus was the stochastic physics related to the diffusion of particles in random fields, plasma turbulence, and the shock acceleration of charged particles in collisionless plasmas. From 1993 to 1995, Frank was head of Goddard's Theoretical High Energy Astrophysics Office and continued to serve as Head of the Theory group. In 2003 he served as Acting Chief of the Laboratory for High Energy Astrophysics. He retired in 2005 and continued his affiliation with NASA as an emeritus scientist at Goddard until his death. As a youngster, Frank showed the signs of curiosity and initiative that indicated he might become an experimentalist. At the memorial service for Frank, his brother related the stories of how Frank had rigged a hidden microphone to play through the family television as his brother courted a young woman on the front porch swing, and how one of Frank's early chemistry experiments caused all the family silverware to turn black. Although Frank started
Eigenvalue distributions of Wilson loops
Energy Technology Data Exchange (ETDEWEB)
Lohmayer, Robert
2010-07-01
In the first part of this thesis, we focus on the distribution of the eigenvalues of the unitary Wilson loop matrix in the two-dimensional case at arbitrary finite N. To characterize the distribution of the eigenvalues, we introduce three density functions (the ''symmetric'', the ''antisymmetric'', and the ''true'' eigenvalue density) which differ at finite N but possess the same infinite-N limit, exhibiting the Durhuus-Olesen phase transition. Using expansions of determinants and inverse determinants in characters of totally symmetric or totally antisymmetric representations of SU(N), the densities at finite N can be expressed in terms of simple sums involving only dimensions and quadratic Casimir invariants of certain irreducible representations of SU(N), allowing for a numerical computation of the densities at arbitrary N to any desired accuracy. We find that the true eigenvalue density, adding N oscillations to the monotonic symmetric density, is in some sense intermediate between the symmetric and the antisymmetric density, which in turn is given by a sum of N delta peaks located at the zeros of the average of the characteristic polynomial. Furthermore, we show that the dependence on N can be made explicit by deriving integral representations for the resolvents associated to the three eigenvalue densities. Using saddle-point approximations, we confirm that all three densities reduce to the Durhuus-Olesen result in the infinite-N limit. In the second part, we study an exponential form of the multiplicative random complex matrix model introduced by Gudowska-Nowak et al. Varying a parameter which can be identified with the area of the Wilson loop in the unitary case, the region of non-vanishing eigenvalue density of the N-dimensional complex product matrix undergoes a topological change at a transition point in the infinite-N limit. We study the transition by a detailed analysis of the average of the
Accurate Jones Matrix of the Practical Faraday Rotator
Institute of Scientific and Technical Information of China (English)
王林斗; 祝昇翔; 李玉峰; 邢文烈; 魏景芝
2003-01-01
The Jones matrix of practical Faraday rotators is often used in the engineering calculation of non-reciprocal optical field. Nevertheless, only the approximate Jones matrix of practical Faraday rotators has been presented by now. Based on the theory of polarized light, this paper presents the accurate Jones matrix of practical Faraday rotators. In addition, an experiment has been carried out to verify the validity of the accurate Jones matrix. This matrix accurately describes the optical characteristics of practical Faraday rotators, including rotation, loss and depolarization of the polarized light. The accurate Jones matrix can be used to obtain the accurate results for the practical Faraday rotator to transform the polarized light, which paves the way for the accurate analysis and calculation of practical Faraday rotators in relevant engineering applications.
La Bob Jones University : hier et aujourd’hui Bob Jones University : Past and Present
Directory of Open Access Journals (Sweden)
Mokhtar Ben Barka
2009-11-01
Full Text Available This article examines the separatist beliefs and practices at Bob Jones University. Firstly, it shows that despite the recent changes, this institution still represents the old face of fundamentalist higher education. Secondly, this essay focuses on the controversy around Republican candidate George W. Bush’s appearance at Bob Jones University.
President Wilson's brain trust: Woodrow Wilson, Francis X. Dercum, and American neurology.
Jacobson, Ryan D
2009-01-01
On October 2, 1919, President Woodrow Wilson suffered a stroke that paralyzed the left half of his body. Wilson's stroke forced the American public to confront stroke, and laypeople came to identify stroke as a nervous disorder, rather than a condition rooted solely in psychological phenomena. His medical care was overseen by Cary Grayson, his personal internist, and Francis X. Dercum, a remarkably accomplished neurologist from Philadelphia. Dercum was very involved in the treatment of the President, from the day of the stroke until years later. While the medical records have been destroyed, some basic facts of Wilson's treatment and rehabilitation can be inferred from the literature. Although Woodrow Wilson was an exceptional patient, his care, albeit administered by some of the most famous physicians of the era, was typical of the time. Therefore, this paper's approach to Wilson's 1919 stroke contextualizes the President's case into the larger scheme of early twentieth-century neurology.
Conformal anomaly of super Wilson loop
Energy Technology Data Exchange (ETDEWEB)
Belitsky, A.V., E-mail: andrei.belitsky@asu.edu [Department of Physics, Arizona State University, Tempe, AZ 85287-1504 (United States)
2012-09-11
Classically supersymmetric Wilson loop on a null polygonal contour possesses all symmetries required to match it onto non-MHV amplitudes in maximally supersymmetric Yang-Mills theory. However, to define it quantum mechanically, one is forced to regularize it since perturbative loop diagrams are not well defined due to presence of ultraviolet divergences stemming from integration in the vicinity of the cusps. A regularization that is adopted by practitioners by allowing one to use spinor helicity formalism, on the one hand, and systematically go to higher orders of perturbation theory is based on a version of dimensional regularization, known as Four-Dimensional Helicity scheme. Recently it was demonstrated that its use for the super Wilson loop at one loop breaks both conformal symmetry and Poincare supersymmetry. Presently, we exhibit the origin for these effects and demonstrate how one can undo this breaking. The phenomenon is alike the one emerging in renormalization group mixing of conformal operators in conformal theories when one uses dimensional regularization. The rotation matrix to the diagonal basis is found by means of computing the anomaly in the Ward identity for the conformal boost. Presently, we apply this ideology to the super Wilson loop. We compute the one-loop conformal anomaly for the super Wilson loop and find that the anomaly depends on its Grassmann coordinates. By subtracting this anomalous contribution from the super Wilson loop we restore its interpretation as a dual description for reduced non-MHV amplitudes which are expressed in terms of superconformal invariants.
Directory of Open Access Journals (Sweden)
Weiss Karl
2008-07-01
Full Text Available Abstract Background In Wilson disease, copper is not sufficiently excreted into bile due to the absence or malfunction of the Wilson protein copper ATPase in the excretory pathway of hepatocytes. Copper is found in sweat. It is unknown if the Wilson protein plays a role in copper excretion into sweat. It is the aim of this study to investigate Wilson protein expression in sweat glands and analysing its effects on copper excretion into sweat in controls and patients with Wilson disease. Methods Immunofluorescent analysis of the Wilson protein in skin samples from normal rat, LEC rat and human skin biopsies were performed. Pilocarpin-induced sweat gland stimulation by iontophoretic transfer adapted from the methods used for cystic fibrosis sweat test was used for sweat induction. Sweat volume, sweat copper concentration, serum ceruloplasmin and serum copper were analysed in 28 Wilson patients and 21 controls. Results The Wilson protein is expressed in human and rat sweat gland epithelia. Copper concentration in sweat is not significantly different between controls and Wilson patients. Wilson patients produce significantly smaller volumes of sweat compared to controls. Sweat production is partially reversible in Wilson patients under medical treatment for Wilson disease or after liver transplantation Conclusion Wilson patients show a reduced sweat production with unaltered sweat copper concentration. The Wilson protein might play an important role in physiological sweat production.
The Universal Askey-Wilson Algebra
Directory of Open Access Journals (Sweden)
Paul Terwilliger
2011-07-01
Full Text Available In 1992 A. Zhedanov introduced the Askey-Wilson algebra AW=AW(3 and used it to describe the Askey-Wilson polynomials. In this paper we introduce a central extension Δ of AW, obtained from AW by reinterpreting certain parameters as central elements in the algebra. We call Δ the universal Askey-Wilson algebra. We give a faithful action of the modular group PSL_2(Z on Δ as a group of automorphisms. We give a linear basis for Δ. We describe the center of Δ and the 2-sided ideal Δ[Δ,Δ]Δ. We discuss how Δ is related to the q-Onsager algebra.
Bruce Medalists at the Mt. Wilson Observatory
Tenn, J. S.
2004-12-01
The institution which succeeded the Mt. Wilson Station of Yerkes Observatory in 1904 has had six names and three sites. From 1948-1980 it was united with Caltech's Palomar Observatory, and since then its main observatory has been in Chile, though still headquartered on Santa Barbara Street in Pasadena. For more than half of the twentieth century it was the leading observatory in the world. One bit of evidence for this is the amazing number of its staff members awarded the Bruce Medal. The Catherine Wolfe Bruce Gold Medal of the Astronomical Society of the Pacific has been awarded for lifetime contributions to astronomy since 1898. It is an international award. It wasn't until 1963 that the number of medalists who had worked primarily in the United States reached half the total. Yet fourteen of the first 87 medalists spent most of their careers at Mt. Wilson, including the period when it was Mt. Wilson and Palomar, and another three were Caltech observers who used the telescopes of the jointly operated observatory. Several more medalists made substantial use of the telescopes on Mt. Wilson and Palomar Mountain. We will discuss highlights of the careers of a number of these distinguished astronomers: directors George Ellery Hale, Walter Adams, Ira Bowen, and Horace Babcock; solar observer and satellite discoverer Seth Nicholson; instrument builder Harold Babcock; galactic and cosmological observers Frederick Seares, Edwin Hubble, Walter Baade, Rudolph Minkowski, and Allan Sandage; and spectroscopists Paul Merrill, Alfred Joy, Olin Wilson, Jesse Greenstein, Maarten Schmidt, and Wallace Sargent. We will touch briefly on others who used Mt. Wilson and/or Palomar, including Harlow Shapley, Joel Stebbins, Charlotte Moore Sitterly, Donald Osterbrock, and Albert Whitford.
Triangular dissections, aperiodic tilings and Jones algebras
Coquereaux, Robert
1994-01-01
The Brattelli diagram associated with a given bicolored Dynkin-Coxeter graph of type A_n determines planar fractal sets obtained by infinite dissections of a given triangle. All triangles appearing in the dissection process have angles that are multiples of \\pi/ (n+1). There are usually several possible infinite dissections compatible with a given n but a given one makes use of n/2 triangle types if n is even. Jones algebra with index [ 4 \\ \\cos^2{\\pi \\over n+1}]^{-1} (values of the discrete range) act naturally on vector spaces associated with those fractal sets. Triangles of a given type are always congruent at each step of the dissection process. In the particular case n=4, there are isometric and the whole structure lead, after proper inflation, to aperiodic Penrose tilings. The other "tilings" associated with other values of the index are discussed and shown to be encoded by equivalence classes of infinite sequences (with appropriate constraints) using only n/2 digits (if n is even) and generalizing the ...
Wilson Loops in Noncommutative Yang Mills
Ishibashi, N; Kawai, H; Kitazawa, Y; Ishibashi, Nobuyuki; Iso, Satoshi; Kawai, Hikaru; Kitazawa, Yoshihisa
2000-01-01
We study the correlation functions of the Wilson loops in noncommutative Yang-Mills theory based upon its equivalence to twisted reduced models. We point out that there is a crossover at the noncommutativity scale. At large momentum scale, the Wilson loops in noncommmutative Yang-Mills represent extended objects. They coincide with those in ordinary Yang-Mills theory in low energy limit. The correlation functions on D-branes in IIB matrix model exhibit the identical crossover behavior. It is observed to be consistent with the supergravity description with running string coupling. We also explain that the results of Seiberg and Witten can be simply understood in our formalism.
Isolated lingual involvement in Wilson's disease.
Choudhary, Neera; Joshi, Laxmikant; Duggal, Ashish; Puri, Vinod; Khwaja, Geeta Anjum
2015-01-01
Lingual involvement can occur in a variety of neurological disorders including pyramidal, extrapyramidal and lower motor neuron disorders. It can be seen in the form of tremor, bradykinesia, dystonia, atrophy and weakness of tongue movements and can clinically present as difficulty in swallowing and dysarthria which can be a source of great discomfort to the patient. We describe a patient who presented with isolated lingual involvement and was diagnosed to have Wilsons's disease. This case emphasizes the clinical variability in presentation of Wilson's disease and importance of early clinical diagnosis.
Spectrum of the Wilson Dirac operator at finite lattice spacings
DEFF Research Database (Denmark)
Akemann, G.; Damgaard, Poul Henrik; Splittorff, Kim;
2011-01-01
We consider the effect of discretization errors on the microscopic spectrum of the Wilson Dirac operator using both chiral Perturbation Theory and chiral Random Matrix Theory. A graded chiral Lagrangian is used to evaluate the microscopic spectral density of the Hermitian Wilson Dirac operator...... as well as the distribution of the chirality over the real eigenvalues of the Wilson Dirac operator. It is shown that a chiral Random Matrix Theory for the Wilson Dirac operator reproduces the leading zero-momentum terms of Wilson chiral Perturbation Theory. All results are obtained for fixed index...... of the Wilson Dirac operator. The low-energy constants of Wilson chiral Perturbation theory are shown to be constrained by the Hermiticity properties of the Wilson Dirac operator....
Goes, Eunice
2014-01-01
"How Labour Governments Fall: From Ramsay MacDonald to Gordon Brown." Timothy Heppell and Kevin Theakston. Palgrave Macmillan. August 2013. --- The previous Labour Government lost office after the party’s longest stint in Government, eventually losing power under Gordon Brown against a backdrop of intellectual fatigue and economic crisis. Eunice Goes reviews Timothy Heppell and Kevin Theakston’s impressive new book on the fall of Labour Governments, and finds recurring themes echoing down th...
Chuck Jones lahkus, tema kangelased elavad edasi / Neeme Korv
Korv, Neeme, 1974-
2002-01-01
Suri Chuck Jones (1912-2002), kuulus USA animafilmirežissöör, kelle animasari "Tom & Jerry" on praegugi Eestis väga populaarne. Ta on loonud enam kui 300 animafilmi, saanud 3 Oscarit ning 1996. aastal ka elutöö Oscari. Eesti lapsed nägid nõukogude ajal esmakordselt Chuck Jones'i loomingut Raivo Järvi lastesaadetes "Laupäeval koos isaga"
Chuck Jones lahkus, tema kangelased elavad edasi / Neeme Korv
Korv, Neeme, 1974-
2002-01-01
Suri Chuck Jones (1912-2002), kuulus USA animafilmirežissöör, kelle animasari "Tom & Jerry" on praegugi Eestis väga populaarne. Ta on loonud enam kui 300 animafilmi, saanud 3 Oscarit ning 1996. aastal ka elutöö Oscari. Eesti lapsed nägid nõukogude ajal esmakordselt Chuck Jones'i loomingut Raivo Järvi lastesaadetes "Laupäeval koos isaga"
Energy Technology Data Exchange (ETDEWEB)
Lashkevich, Michael; Pugai, Yaroslav [Landau Institute for Theoretical Physics, 142432 Chernogolovka, Moscow Region (Russian Federation); Moscow Institute of Physics and Technology, 141707 Dolgoprudny, Moscow Region (Russian Federation)
2013-12-11
We continue the study of form factors of descendant operators in the sinh- and sine-Gordon models in the framework of the algebraic construction proposed in [1]. We find the algebraic construction to be related to a particular limit of the tensor product of the deformed Virasoro algebra and a suitably chosen Heisenberg algebra. To analyze the space of local operators in the framework of the form factor formalism we introduce screening operators and construct singular and cosingular vectors in the Fock spaces related to the free field realization of the obtained algebra. We show that the singular vectors are expressed in terms of the degenerate Macdonald polynomials with rectangular partitions. We study the matrix elements that contain a singular vector in one chirality and a cosingular vector in the other chirality and find them to lead to the resonance identities already known in the conformal perturbation theory. Besides, we give a new derivation of the equation of motion in the sinh-Gordon theory, and a new representation for conserved currents.
Lashkevich, Michael
2013-01-01
We continue the study of form factors of descendant operators in the sinh- and sine-Gordon models in the framework of the algebraic construction proposed in [arXiv:0812.4776]. We find the algebraic construction to be related to a particular limit of the tensor product of the deformed Virasoro algebra and a suitably chosen Heisenberg algebra. To analyze the space of local operators in the framework of the form factor formalism we introduce screening operators and construct singular and cosingular vectors in the Fock spaces related to the free field realization of the obtained algebra. We show that the singular vectors are expressed in terms of the degenerate Macdonald polynomials with rectangular partitions. We study the matrix elements that contain a singular vector in one chirality and a cosingular vector in the other chirality and find them to lead to the resonance identities already known in the conformal perturbation theory. Besides, we give a new derivation of the equation of motion in the sinh-Gordon th...
Volume reduction through perturbative Wilson loops
Perez, Margarita Garcia; Okawa, Masanori
2016-01-01
We derive the perturbative expansion of Wilson loops to order g^4 in a SU(N) lattice gauge theory with twisted boundary conditions. Our expressions show that the thermodynamic limit is attained at infinite N for any number of lattice sites and allow to quantify the deviations from volume independence at finite large N as a function of the twist.
Wilson disease : from clinical to molecular
Houwen, Roderick Henk Johan
1991-01-01
Wilson disease is an autosomal recessive copper storage disease. It is characterized by an inability of the liver to; excrete copper into bile and to incorporate copper into ceruloplasmin. This results in a gradual accumulation of copper in the liver and subsequently in the brain and other organs, I
Spasmodic Muscle Cramps and Wilson Disease
Directory of Open Access Journals (Sweden)
J Gordon Millichap
2013-12-01
Full Text Available Investigators at Ann & Robert H. Lurie Children's Hospital of Chicago report a case of Wilson disease (WD in a 10-year-old-boy presenting with 3 months of increasingly severe spasmodic muscle cramps and weakness in lower extremities, upper extremities, and cramps in face and chest.
Abelian Duality and Abelian Wilson Loops
Zucchini, R
2003-01-01
We consider a pure U(1) quantum gauge field theory on a general Riemannian compact four manifold. We compute the partition function with Abelian Wilson loop insertions. We find its duality covariance properties and derive topological selection rules. Finally, we show that, to have manifest duality, one must assume the existence of twisted topological sectors besides the standard untwisted one.
The Cora Wilson Stewart Moonlight Schoolhouse
Rose, Harold; Curtis, Mike
1974-01-01
Describes the establishment of adult education programs on "moonlit nights" by Cora Wilson Stewart, Superintendent of Rowan County Schools in Kentucky (1904-1912). Over 1,200 adults signed up the first year to take such courses as vocal music, reading, writing, spelling, arithmetic, and drills. From this activity the Illiteracy…
Cora Wilson Stewart: Crusader against Illiteracy.
Nelms, Willie
This book is a biography of Cora Wilson Stewart, a Rowan County, Kentucky, school superintendent who rose to prominence with the establishment of the Moonlight Schools for adults with low literacy levels in 1911. It presents the details of her Kentucky crusade against illiteracy, then examines the personal part of her life as well as her later…
Wilson lines in quantum field theory
Energy Technology Data Exchange (ETDEWEB)
Cherednikov, Igor Olegovich [Antwerpen Univ., Antwerp (Belgium). Fysica Dept.; Joint Institute of Nuclear Research, Moscow (Russian Federation). Bogoliubov Lab. of Theoretical Physics; Mertens, Tom; Veken, Frederik F. van der [Antwerpen Univ., Antwerp (Belgium). Fysica Dept.
2014-07-01
Wilson lines (also known as gauge links or eikonal lines) can be introduced in any gauge field theory. Although the concept of the Wilson exponentials finds an enormously wide range of applications in a variety of branches of modern quantum field theory, from condensed matter and lattice simulations to quantum chromodynamics, high-energy effective theories and gravity, there are surprisingly few books or textbooks on the market which contain comprehensive pedagogical introduction and consecutive exposition of the subject. The objective of this book is to get the potential reader acquainted with theoretical and mathematical foundations of the concept of the Wilson loops in the context of modern quantum field theory, to teach him/her to perform independently some elementary calculations with Wilson lines, and to familiarize him/her with the recent development of the subject in different important areas of research. The target audience of the book consists of graduate and postgraduate students working in various areas of quantum field theory, as well as researchers from other fields.
Wilson Fermions with Four Fermion Interactions
DEFF Research Database (Denmark)
Rantaharju, Jarno; Drach, Vincent; Hietanen, Ari;
2015-01-01
We present a lattice study of a four fermion theory, known as Nambu Jona-Lasinio (NJL) theory, via Wilson fermions. Four fermion interactions naturally occur in several extensions of the Standard Model as a low energy parameterisation of a more fundamental theory. In models of dynamical electrowe...
Lyapunov instabilities of Lennard-Jones fluids.
Yang, Hong-liu; Radons, Günter
2005-03-01
Recent work on many-particle systems reveals the existence of regular collective perturbations corresponding to the smallest positive Lyapunov exponents (LEs), called hydrodynamic Lyapunov modes. Until now, however, these modes have been found only for hard-core systems. Here we report results on Lyapunov spectra and Lyapunov vectors (LVs) for Lennard-Jones fluids. By considering the Fourier transform of the coordinate fluctuation density u((alpha)) (x,t) , it is found that the LVs with lambda approximately equal to 0 are highly dominated by a few components with low wave numbers. These numerical results provide strong evidence that hydrodynamic Lyapunov modes do exist in soft-potential systems, although the collective Lyapunov modes are more vague than in hard-core systems. In studying the density and temperature dependence of these modes, it is found that, when the value of the Lyapunov exponent lambda((alpha)) is plotted as function of the dominant wave number k(max) of the corresponding LV, all data from simulations with different densities and temperatures collapse onto a single curve. This shows that the dispersion relation lambda((alpha)) vs k(max) for hydrodynamical Lyapunov modes appears to be universal for the low-density cases studied here. Despite the wavelike character of the LVs, no steplike structure exists in the Lyapunov spectrum of the systems studied here, in contrast to the hard-core case. Further numerical simulations show that the finite-time LEs fluctuate strongly. We have also investigated localization features of LVs and propose a length scale to characterize the Hamiltonian spatiotemporal chaotic states.
An eigenvalue problem for the associated Askey-Wilson polynomials
Bruder, Andrea; Suslov, Sergei K
2012-01-01
To derive an eigenvalue problem for the associated Askey-Wilson polynomials, we consider an auxiliary function in two variables which is related to the associated Askey-Wilson polynomials introduced by Ismail and Rahman. The Askey-Wilson operator, applied in each variable separately, maps this function to the ordinary Askey-Wilson polynomials with different sets of parameters. A third Askey-Wilson operator is found with the help of a computer algebra program which links the two, and an eigenvalue problem is stated.
NEWS: John Goronwy Jones (1920-1999)
Jennison, Brenda M.
2000-05-01
John Goronwy Jones Gron Jones, as he was known to all, was a champion of Physics Education and his death, shortly before his eightieth birthday, robbed physics teachers of a colleague who fought many battles on their behalf. He was not shy of taking issue with anyone in authority who might be putting forward policies which would harm his great love: Physics Education and Physics Teaching. His photograph shows a man with an impish grin, looking friend and foe alike straight in the eye, before delivering the death blow to an argument which was founded on less than common sense. At other times he would listen patiently to the woes of colleagues before offering them fatherly/grandfatherly advice so that whoever was on the receiving end would go away feeling better for the encounter. Gron was born in Swansea and educated at Lewis Boys Grammar School in Glamorgan before entering University College Cardiff first of all as a mathematician before graduating in Physics in 1941. After his war service in the RAF, working on signals and radar development, he returned to do an MSc in X-ray crystallography before completing a PGCE in Bristol. What then passed for teacher training in all institutions left him wary of returning to train teachers himself but after 14 years spent teaching physics in three schools he returned to Cardiff and began a 25 year career in teacher training. He and his two colleagues, Clifford Othen (chemistry) and Douglas Hillier (biology) built up the Cardiff Science Centre as a focus for initial and in-service science teacher training in South Wales. The triumvirate was well known and a power to be reckoned with. They created links between the University Science Departments and the Schools. Gron knew the local schools and their physics teachers intimately. Cardiff became a focus for science education both nationally and internationally. He was a frequent attender at both ICPE (International Commission for Physics Education) and GIREP (International Physics
Ruktanonchai, Nick W; Smith, David L; De Leenheer, Patrick
2016-09-01
We consider the dynamics of a mosquito-transmitted pathogen in a multi-patch Ross-Macdonald malaria model with mobile human hosts, mobile vectors, and a heterogeneous environment. We show the existence of a globally stable steady state, and a threshold that determines whether a pathogen is either absent from all patches, or endemic and present at some level in all patches. Each patch is characterized by a local basic reproduction number, whose value predicts whether the disease is cleared or not when the patch is isolated: patches are known as "demographic sinks" if they have a local basic reproduction number less than one, and hence would clear the disease if isolated; patches with a basic reproduction number above one would sustain endemic infection in isolation, and become "demographic sources" of parasites when connected to other patches. Sources are also considered focal areas of transmission for the larger landscape, as they export excess parasites to other areas and can sustain parasite populations. We show how to determine the various basic reproduction numbers from steady state estimates in the patched network and knowledge of additional model parameters, hereby identifying parasite sources in the process. This is useful in the context of control of the infection on natural landscapes, because a commonly suggested strategy is to target focal areas, in order to make their corresponding basic reproduction numbers less than one, effectively turning them into sinks. We show that this is indeed a successful control strategy-albeit a conservative and possibly expensive one-in case either the human host, or the vector does not move. However, we also show that when both humans and vectors move, this strategy may fail, depending on the specific movement patterns exhibited by hosts and vectors.
[Wilson's disease: clinical spectrum of liver disease].
Ochoa Palominos, Alejandra; Ibáñez Samaniego, Luis; Catalina Rodríguez, María-Vega; Pajares Díaz, José; Clemente Ricote, Gerardo
2013-02-01
Wilson's disease is a hereditary autosomal recessive disorder of copper metabolism,characterized by copper accumulation in the liver and brain. This rare entity, which has a broad clinical spectrum, is often difficult to diagnose and should therefore always be suspected in patients with liver disease of unclear cause. We describe two types of manifestation of liver disease in two patients; the first developed fulminant hepatic failure requiring urgent liver transplantation and the second showed advanced chronic liver disease and received standard medical treatment. The objective of this clinical observation is to analyze the diagnosis of Wilson's disease in two patients with distinct onset, illustrating the broad clinical spectrum of the disease, and its treatment.
ADHM Revisited: Instantons and Wilson Lines
Tong, David
2014-01-01
We revisit the well-studied D0-D4 system of D-branes and its relationship to the ADHM construction. It is well known that the D0-branes appear as instantons in the D4-brane worldvolume. We add a Wilson line to the D4-brane in the guise of an extended fundamental string and determine how this affects the D0-brane dynamics. As the D0-brane moves in the presence of the Wilson line, it experiences a Lorentz force, proportional to its Yang-Mills gauge connection. From the perspective of the D0-brane quantum mechanics, this force emerges through the ADHM construction of the self-dual gauge connection.
Symmetries of Ginsparg-Wilson Chiral Fermions
Mandula, Jeffrey E
2009-01-01
The group structure of the variant chiral symmetry discovered by Luscher in the Ginsparg-Wilson description of lattice chiral fermions is analyzed. It is shown that the group contains an infinite number of linearly independent symmetry generators, and the Lie algebra is given explicitly. CP is an automorphism of this extended chiral group, and the CP transformation properties of the symmetry generators are found. The group has an infinite-parameter subgroup, and the factor group whose elements are its cosets is isomorphic to the continuum chiral symmetry group. Features of the currents associated with these symmetries are discussed, including the fact that some different, non-commuting symmetry generators lead to the same Noether current. These are universal features of lattice chiral fermions based on the Ginsparg-Wilson relation; they occur in the overlap, domain-wall, and perfect-action formulations. In a solvable example - free overlap fermions - these non-canonical elements of lattice chiral symmetry are...
Wilson fermions in the epsilon regime
Bär, Oliver; Schaefer, Stefan
2009-01-01
We extend the epsilon-expansion of continuum chiral perturbation theory to nonzero lattice spacing in the framework of Wilson Chiral Perturbation Theory. We distinguish various regimes by defining the relative power counting of the quark mass m and the lattice spacing a. We observe that for m ~ a Lambda^2_QCD, the explicit breaking of chiral symmetry in Wilson fermions is still driven by the quark mass and lattice corrections are highly suppressed. The lattice spacing effects become more pronounced for smaller quark masses and may lead to non-trivial corrections of the continuum results at next-to-leading order. We compute these corrections for standard current and density correlation functions. A fit to lattice data shows that these corrections are small, as expected.
Conformal anomaly of super Wilson loop
Belitsky, A V
2012-01-01
Classically supersymmetric Wilson loop on a null polygonal contour possesses all symmetries required to match it onto non-MHV amplitudes in maximally supersymmetric Yang-Mills theory. However, to define it quantum mechanically, one is forced to regularize it since perturbative loop diagrams are not well-defined due to presence of ultraviolet divergences stemming from integration in the vicinity of the cusps. A regularization that is adopted by practitioners by allowing one to use spinor helicity formalism, on the one hand, and systematically go to higher orders of perturbation theory is based on a version of dimensional regularization, known as Four-Dimensional Helicity scheme. Recently it was demonstrated that its use for the super Wilson loop at one loop breaks both conformal symmetry and Poincare supersymmetry. Presently, we exhibit the origin for these effects and demonstrate how one can undo this breaking. The phenomenon is alike the one emerging in renormalization group mixing of conformal operators in ...
Super Wilson Loops and Holonomy on Supermanifolds
Groeger, Josua
2013-01-01
The classical Wilson loop is the gauge-invariant trace of the parallel transport around a closed path with respect to a connection on a vector bundle over a smooth manifold. We build a precise mathematical model of the super Wilson loop, an extension introduced by Mason-Skinner and Caron-Huot, by endowing the objects occurring with auxiliary Gra{\\ss}mann generators coming from S-points. A key feature of our model is a supergeometric parallel transport, which allows for a natural notion of holonomy on a supermanifold as a Lie group valued functor. Our main results for that theory comprise an Ambrose-Singer theorem as well as a natural analogon of the holonomy principle. Finally, we compare our holonomy functor with the holonomy supergroup introduced by Galaev in the common situation of a topological point. It turns out that both theories are different, yet related in a sense made precise.
Bloch state tomography using Wilson lines
Li, Tracy; Duca, Lucia; Reitter, Martin; Grusdt, Fabian; Demler, Eugene; Endres, Manuel; Schleier-Smith, Monika; Bloch, Immanuel; Schneider, Ulrich
2016-05-01
Topology and geometry are essential to our understanding of modern physics, underlying many foundational concepts from high-energy theories, quantum information, and condensed-matter physics. In condensed-matter systems, a wide range of phenomena stem from the geometry of the band eigenstates, which is encoded in the matrix-valued Wilson line for general multiband systems. Using an ultracold gas of rubidium atoms loaded in a honeycomb optical lattice, we realize strong-force dynamics in Bloch bands that are described by Wilson lines and observe an evolution in the band populations that directly reveals the band geometry. Our technique enables a full determination of band eigenstates, Berry curvature, and topological invariants, including single- and multiband Chern and Z2 numbers.
Supersymmetric Wilson loops at two loops
Bassetto, Antonio; Pucci, Fabrizio; Seminara, Domenico
2008-01-01
We study the quantum properties of certain BPS Wilson loops in ${\\cal N}=4$ supersymmetric Yang-Mills theory. They belong to a general family, introduced recently, in which the addition of particular scalar couplings endows generic loops on $S^3$ with a fraction of supersymmetry. When restricted to $S^2$, their quantum average has been further conjectured to be exactly computed by the matrix model governing the zero-instanton sector of YM$_2$ on the sphere. We perform a complete two-loop analysis on a class of cusped Wilson loops lying on a two-dimensional sphere, finding perfect agreement with the conjecture. The perturbative computation reproduces the matrix-model expectation through a highly non-trivial interplay between ladder diagrams and self-energies/vertex contributions, suggesting the existence of a localization procedure.
[Severe hemolytic jaundice and Wilson's disease].
Storck, D; Bareiss, P; Jesel, B; Warter, J
1976-12-01
The onset of spontaneous hemolytic jaundice in a young subject should lead to the search for Wilson's disease when clinical examination reveals cirrhosis. This hemolysis may evolve in the form of severe jaundice to a stage where the cirrhosis remains usually latent or well tolerated. The intervention of a toxic, allergic of infective factor liable to produce a hepatic lesion which frees a dose of copper sufficient to trigger off hemolysis, is discussed. The mechanism of the latter, that of the coagulation disorders observed, liver cell failure and widespread intravascular coagulation, are analysed in this paper and compared with data in the literature. The dramatic character of the case indicates that it is necessary to treat as a routine with penicillamine all homozygous forms of Wilson's disease.
Flight into sanity. Jones's allegation of Ferenczi's mental deterioration reconsidered.
Bonomi, C
1999-06-01
In 'The Life and Work of Sigmund Freud', Volume III, Ernest Jones explained Ferenczi's final contributions as the product of a mental deterioration based on a progressive psychosis. Erich Fromm collected various testimonies by witnesses of Ferenczi's last years, all contrasting with Jones's assertions, and challenged Jones's manner of writing history. However, since Fromm was himself a dissident, and his witnesses were pupils, relatives or friends of Ferenczi's, they were discarded as 'partisans'. The present study aims at reconsidering the question of Ferenczi's insanity on the basis of many unpublished documents. The consulted documents do not support Jones's allegation of Ferenczi's insanity. At the same time, they show that Jones's allegation was not a one-man fabrication, but reflected a shared belief, eliciting many questions about the nature of this belief, the lack of scrutiny that characterised its spreading, and its possible function within the psychoanalytic community. It is suggested that Ferenczi's personality and teaching, especially his emphasis on the need to accept the patient's criticism, contrasted with the dominant conception of psychoanalysis, based on the analyst's infallibility.
Indian Academy of Sciences (India)
2017-01-01
We describe how Wilson’s concept of the renormalizationgroup revolutionized our understanding of the physics ofphase transitions, and of quantum field theory in general. Weunderline the key ideas of Wilson, based on earlier ideas ofLandau, Ginzburg, Kadanoff and many others, which gaveus an insight into the observed universality of diverse physicalphenomena, and the remarkable efficacy of a few simplemodels to describe them.
Rectangular Wilson Loops at Large N
Lohmayer, Robert
2012-01-01
This work is about pure Yang Mills theory in four Euclidean dimensions with gauge group SU(N). We study rectangular smeared Wilson loops on the lattice at large N and relatively close to the large-N transition point in their eigenvalue density. We show that the string tension can be extracted from these loops but obtain a shape dependence different from the prediction of effective string theory.
Symmetric Wilson Loops beyond leading order
Chen-Lin, Xinyi
2016-01-01
We study the circular Wilson loop in the symmetric representation of U(N) in $\\mathcal{N} = 4$ super-Yang-Mills (SYM). In the large N limit, we computed the exponentially-suppressed corrections for strong coupling, which suggests non-perturbative physics in the dual holographic theory. We also computed the next-to-leading order term in 1/N, and the result matches with the exact result from the k-fundamental representation.
Nucleon electromagnetic form factors with Wilson fermions
Energy Technology Data Exchange (ETDEWEB)
Goeckeler, M. [Regensburg Univ. (Germany). Inst. fuer Theoretische Physik; Haegler, P. [Technische Univ. Muenchen, Garching (Germany). Inst. fuer Theoretische Physik; Horsley, R. [Edinburgh Univ. (GB). School of Physics] (and others)
2007-10-15
The nucleon electromagnetic form factors continue to be of major interest for experimentalists and phenomenologists alike. They provide important insights into the structure of nuclear matter. For a range of interesting momenta they can be calculated on the lattice. The limiting factor continues to be the value of the pion mass. We present the latest results of the QCDSF collaboration using gauge configurations with two dynamical, non-perturbatively improved Wilson fermions at pion masses as low as 350 MeV. (orig.)
Anisotropy tuning with the Wilson flow
Borsanyi, S; Fodor, Z; Katz, S D; Krieg, S; Kurth, T; Mages, S; Schafer, A; Szabo, K K
2012-01-01
We use the Wilson flow to define the gauge anisotropy at a given physical scale. We demonstrate the use of the anisotropic flow by performing the tuning of the bare gauge anisotropy in the tree-level Symanzik action for several lattice spacings and target anisotropies. We use this method to tune the anisotropy parameters in full QCD, where we also exploit the diminishing effect of a well chosen smearing on the renormalization of the fermion anisotropy.
The Legacy of G. Wilson Knight
Directory of Open Access Journals (Sweden)
Raw Laurence
2017-06-01
Full Text Available G. Wilson Knight (1897-1985 was one of the most influential Shakespearean critics of the mid-twentieth century. This piece surveys his work from 1930 until the early 1980s. Much affected by the First World War, he developed a style of criticism based on Christian principles of respect for other people and belief in an all-powerful God. Many of his most famous pieces (in THE WHEEL OF FIRE, for instance argue for human insignificance in an indifferent universe. It is up to all of us as individuals to develop methods of coping with this world. Wilson Knight’s ideas gained particular currency during the Second World War, when Britain’s very future seemed at risk due to the threat of Nazi invasion. Although much derided for his use of transcendent language—especially by his contemporary F. R. Leavis—Wilson Knight’s ideas seem to have acquired new significance in a globalized world, where individuals fight to main their identity in a technology-driven environment.
Ted Wilson passes on the torch
2003-01-01
As part of the Laboratory's outreach programme, the CERN Accelerator School (CAS) brings together students and experienced physicists from all over the world with the aim of promoting the understanding of accelerator physics. As head of the School for 11 years, Ted Wilson became a CERN ambassador to the outside community. He retired in March, handing over the reigns of the CAS to Daniel Brandt. Ted Wilson and his assistant, Suzanne von Wartburg, during an EPAC meeting in 1994.The accelerator schools allowed some time for relaxation in the local surrounding for students as well as for the director of CAS.As a boy, Ted Wilson could have embarked on a career in pop music rather than physics, rubbing shoulders at secondary school in Liverpool with two of the future Beatles. But prefering classical music and answering the call of science, he took the more serious of the two paths, studying physics first at Oxford University then at the Rutherford Laboratory. After a year at CERN and four years at the Rutherford La...
Cluster fusion algorithm: application to Lennard-Jones clusters
DEFF Research Database (Denmark)
Solov'yov, Ilia; Solov'yov, Andrey V.; Greiner, Walter
2008-01-01
paths up to the cluster size of 150 atoms. We demonstrate that in this way all known global minima structures of the Lennard-Jones clusters can be found. Our method provides an efficient tool for the calculation and analysis of atomic cluster structure. With its use we justify the magic number sequence...... for the clusters of noble gas atoms and compare it with experimental observations. We report the striking correspondence of the peaks in the dependence of the second derivative of the binding energy per atom on cluster size calculated for the chain of the Lennard-Jones clusters based on the icosahedral symmetry......We present a new general theoretical framework for modelling the cluster structure and apply it to description of the Lennard-Jones clusters. Starting from the initial tetrahedral cluster configuration, adding new atoms to the system and absorbing its energy at each step, we find cluster growing...
Cluster fusion algorithm: application to Lennard-Jones clusters
DEFF Research Database (Denmark)
Solov'yov, Ilia; Solov'yov, Andrey V.; Greiner, Walter
2006-01-01
paths up to the cluster size of 150 atoms. We demonstrate that in this way all known global minima structures of the Lennard-Jones clusters can be found. Our method provides an efficient tool for the calculation and analysis of atomic cluster structure. With its use we justify the magic number sequence...... for the clusters of noble gas atoms and compare it with experimental observations. We report the striking correspondence of the peaks in the dependence of the second derivative of the binding energy per atom on cluster size calculated for the chain of the Lennard-Jones clusters based on the icosahedral symmetry......We present a new general theoretical framework for modelling the cluster structure and apply it to description of the Lennard-Jones clusters. Starting from the initial tetrahedral cluster configuration, adding new atoms to the system and absorbing its energy at each step, we find cluster growing...
Guts of surfaces and the colored Jones polynomial
Futer, David; Purcell, Jessica
2013-01-01
This monograph derives direct and concrete relations between colored Jones polynomials and the topology of incompressible spanning surfaces in knot and link complements. Under mild diagrammatic hypotheses, we prove that the growth of the degree of the colored Jones polynomials is a boundary slope of an essential surface in the knot complement. We show that certain coefficients of the polynomial measure how far this surface is from being a fiber for the knot; in particular, the surface is a fiber if and only if a particular coefficient vanishes. We also relate hyperbolic volume to colored Jones polynomials. Our method is to generalize the checkerboard decompositions of alternating knots. Under mild diagrammatic hypotheses, we show that these surfaces are essential, and obtain an ideal polyhedral decomposition of their complement. We use normal surface theory to relate the pieces of the JSJ decomposition of the complement to the combinatorics of certain surface spines (state graphs). Since state graphs have p...
Guts of surfaces and the colored Jones polynomial
Futer, David; Purcell, Jessica S
2011-01-01
This work derives direct and concrete relations between colored Jones polynomials and the topology of incompressible spanning surfaces in knot and link complements. Under mild diagrammatic hypotheses that arise naturally in the study of knot polynomial invariants (A-adequacy), we prove that the growth of the degree of the colored Jones polynomials is a boundary slope of an essential surface in the knot complement. We show that certain coefficients of the polynomial measure how far this surface is from being a fiber in the knot complement; in particular, the surface is a fiber if and only if a particular coefficient vanishes. Our results also yield concrete relations between hyperbolic geometry and colored Jones polynomials: for certain families of links, coefficients of the polynomials determine the hyperbolic volume to within a factor of 4. Our approach is to generalize the checkerboard decompositions of alternating knots. Under mild diagrammatic hypotheses (A-adequacy), we show that the checkerboard knot su...
In-Office Jones tube exchange using the Seldinger technique.
Eloy, Jean Anderson; Choudhry, Osamah J; Shukla, Pratik A; Langer, Paul D
2013-01-01
Conjunctivodacryocystorhinostomy (CDCR) with Jones tube placement is usually performed as a primary procedure for severe stenosis or obstruction of both upper and lower canaliculi of the lacrimal drainage pathway, or occasionally, after unsuccessful dacryocystorhinostomy (DCR). Jones tube obstruction is quite common, and often requires removal of the obstructed tube and replacement or exchange of the tube in the operating room. This procedure is typically performed under general anesthesia, and is associated with the risks of general anesthesia, a significant investment of time, and the cost of the operating suite. Recently, there has been a movement toward in-office procedures in otolaryngology and ophthalmology due to greater patient satisfaction and savings in time and money for patients and physicians. In this report, we describe a novel in-office method to exchange an obstructed Jones tube that provides the aforementioned benefits while preserving patient comfort. No similar case has been previously reported in the literature.
Elisabeth Bennet y Bridget Jones: del protofeminismo al postfeminismo
Valero Valero, Dori
2013-01-01
XVIII Jornades de Foment de la Investigació de la Facultat de Ciències Humanes i Socials (Any 2013) Las teorías feministas se han introducido en la literatura de ficción facilitando modelos alternativos a las lectoras. Las heroínas llevan a cabo una tarea de «resistencia feminista», y tomaremos los siguientes ejemplos: Elizabeth Bennet, Orgullo y prejuicio (1813) y Bridget Jones, El diario de Bridget Jones (1999). Jane Austen construye protagonistas femeninas que responden a las est...
Elisabeth Bennet y Bridget Jones: del protofeminismo al postfeminismo
Valero Valero, Dori
2013-01-01
XVIII Jornades de Foment de la Investigació de la Facultat de Ciències Humanes i Socials (Any 2013) Las teorías feministas se han introducido en la literatura de ficción facilitando modelos alternativos a las lectoras. Las heroínas llevan a cabo una tarea de «resistencia feminista», y tomaremos los siguientes ejemplos: Elizabeth Bennet, Orgullo y prejuicio (1813) y Bridget Jones, El diario de Bridget Jones (1999). Jane Austen construye protagonistas femeninas que responden a las est...
Zeros of the Jones polynomials for families of pretzel links
Jin, Xian'an; Zhang, Fuji
2003-10-01
In this paper, a general method for computing the Tutte polynomial of the subdivision of a graph is explained. As an application to the subdivision of sheaf graph which consists of two vertices joined by some parallel edges, we obtain the explicit expressions of the Jones polynomials for some families of the pretzel links. Motivated by the work of Chang and Shrock, we investigate the zeros distribution of its Jones polynomial for each family when the number of crossings goes to infinity, and generalize some of their results.
Imaginando Palmares: a obra de Gayl Jones Imagining Palmares: the work of Gayl Jones
Directory of Open Access Journals (Sweden)
Stelamaris Coser
2005-12-01
Full Text Available O longo poema narrativo Song for Anninho (1981, da escritora negra Gayl Jones (Estados Unidos, interfere na narrativa da história colonial brasileira ao resgatar a figura feminina na República de Palmares, reescrever a saga de resistência dos palmaristas do ponto de vista imaginário de uma mulher negra do século XVII e, através dela, reinventar o cotidiano, os amores, as disputas e os sonhos das pessoas comuns que integravam o quilombo. O texto reflete sobre a verdade histórica, o aspecto construído de documentos, as seleções e exclusões da linguagem, e a importância do relato oral para o conhecimento de vivências e identidades à margem da história oficial. Nessa versão especial, o relato dramático do sonho, da luta e da destruição do mais famoso quilombo brasileiro usa a imaginação literária para expandir a memória e os arquivos de um dos fatos mais importantes da história das Américas, contribuindo para estimular o diálogo interamericano e iluminar a diáspora africana no Brasil e no continente.The long narrative poem Song for Anninho (1981, written by black U.S. writer Gayl Jones, interferes in the narrative of Brazilian colonial history as it highlights the female presence in the Republic of Palmares, rewrites the tale of resistance from the point of view of a black woman in the 17th Century, and, through her, reinvents the everyday lives, loves, disputes, and dreams of common people in the quilombo. The text reflects about historical truth, the constructed character of documents, selections and exclusions in language, and the importance of oral accounts to give visibility to experiences and identities marginalized by official history. In this special version, the dramatic report of the dreams, struggles, and destruction of the most famous Brazilian quilombo uses literary imagination to expand the memory and the archives of one of the most important facts in the history of the Americas, contributing to stimulate
Cell therapy to remove excess copper in Wilson's disease.
Gupta, Sanjeev
2014-05-01
To achieve permanent correction of Wilson's disease by a cell therapy approach, replacement of diseased hepatocytes with healthy hepatocytes is desirable. There is a physiological requirement for hepatic ATP7B-dependent copper (Cu) transport in bile, which is deficient in Wilson's disease, producing progressive Cu accumulation in the liver or brain with organ damage. The ability to repopulate the liver with healthy hepatocytes raises the possibility of cell therapy in Wilson's disease. Therapeutic principles included reconstitution of bile canalicular network as well as proliferation in transplanted hepatocytes, despite toxic amounts of Cu in the liver. Nonetheless, cell therapy studies in animal models elicited major differences in the mechanisms driving liver repopulation with transplanted hepatocytes in Wilson's disease versus nondiseased settings. Recently, noninvasive imaging was developed to demonstrate Cu removal from the liver, including after cell therapy in Wilson's disease. Such developments will help advance cell/gene therapy approaches, particularly by offering roadmaps for clinical trials in people with Wilson's disease.
Clinical zinc deficiency as early presentation of Wilson disease.
Van Biervliet, Stephanie; Küry, Sébastien; De Bruyne, Ruth; Vanakker, Olivier M; Schmitt, Sébastien; Vande Velde, Saskia; Blouin, Eric; Bézieau, Stéphane
2015-04-01
Wilson disease is a rare autosomal recessive disorder of the copper metabolism caused by homozygous or compound heterozygous mutations in the ATP-ase Cu(2+) transporting polypeptide (ATP7B) gene. The copper accumulation in different organs leads to the suspicion of Wilson disease. We describe a child with clinical zinc deficiency as presenting symptom of Wilson disease, which was confirmed by 2 mutations within the ATP7B gene and an increased copper excretion.
Intractable Rickets as Presenting Feature of Wilson's Disease
Directory of Open Access Journals (Sweden)
A Bahrami-Ahmadi
2004-10-01
Full Text Available Rickets by definition is a condition in which the bone mineralization is defective. Among the large cause of Rickets (Vitamin D deficiency, gastrointestinal disorders, acidosis, renal tubular abnormalities..., Wilson's disease is a relatively rare cause. There are few cases of Wilson's disease presenting first as rickets in the literature. Here we present an Afghan girl with Wilson's disease presenting with intractable Rickets.
Molecular studies of ceruloplasmin deficiency in Wilson's disease.
Czaja, M J; Weiner, F R; Schwarzenberg, S J; Sternlieb, I.; Scheinberg, I. H.; Van Thiel, D.H.; LaRusso, N F; Giambrone, M. A.; Kirschner, R.; Koschinsky, M L
1987-01-01
Deficiency of serum ceruloplasmin is a characteristic biochemical abnormality of Wilson's disease, although the mechanism of this finding is unknown. Ceruloplasmin messenger RNA (mRNA) levels were therefore examined in five patients with Wilson's disease and five controls with other types of hepatic disease. Northern and dot blot hybridizations showed that detectable ceruloplasmin mRNA was present in all of the patients with Wilson's disease, including one patient with no detectable serum cer...
Procedural learning changes in patients with Wilson's disease
Institute of Scientific and Technical Information of China (English)
Yumei Jiang; Xiang Shen; Xiaoping Wang; Wenjie Li
2011-01-01
In the present study, we compared explicit memory performance, using the Wechsler Memory Scale, and implicit memory performance, using the Nissen software version of the serial reaction time task, in patients with Wilson's disease to normal controls. The Wilson's disease patients exhibited deficits in explicit memory tasks, such as figure recall and understanding memory. Moreover, the Wilson's disease patients exhibited deficits in implicit memory tasks, including significantly prolonged response times. These findings indicate that Wilson's disease patients have explicit and implicit partial memory impairments.
Public lecture | "Science and society" by Bob Jones | 22 May
2014-01-01
Public lecture: "Science and society: the impact of computing at CERN on society" by Bob Jones 22 May at 7.30 p.m. Globe of Science and Innovation Lecture in English, translated in French. Entrance free. Limited number of seats. Reservation essential: +41 22 767 76 76 or cern.reception@cern.ch
Edward Burne-Jones' Heavenly Conception: A Biblical Cosmos
Cheney, L. D. G.
2016-01-01
Edward Burne-Jones was a Pre-Raphaelite artist and designer, who collaborated with William Morris on many decorative arts (stained glass windows, book illustrations, ceramic and tapestry designs). He was a founding partner in the firm Morris, Marshall, Faulkner & Company. Burne-Jones composed The Days of Creation between 1870 and 1876 for the Morris firm. These paintings were executed in gouache and gold paint, and cartoons were made for tile and in stained glass, for the Church of St. Editha at Tamworth in Staffordshire. Burne-Jones' creation was highly praised and elegantly described by Oscar Wilde: “The picture is divided into six compartments, each representing a day in the Creation of the World, under the symbol of an angel holding a crystal globe, within which is shown the work of a day.” This paper will examine how Burne-Jones visualized an unusual celestial creation where angels holding magical spheres unveil the divine manifestation for the creation of a terrestrial realm. He created a cosmic utopia of the natural world.
Hopping in a supercooled binary Lennard-Jones liquid
DEFF Research Database (Denmark)
Schrøder, Thomas; Dyre, Jeppe
1998-01-01
A binary LennardJones liquid has been investigated by molecular dynamics at equilibrium supercooled conditions. At the lowest temperature investigated, hopping is present in the system as indicated by a secondary peak in 4r2Gs(r,t), where Gs(r,t) is the van Hove self correlation function...
Free energy of the Lennard-Jones solid
Hoef, van der Martin A.
2000-01-01
We have determined a simple expression for the absolute Helmholtz free energy of the fcc Lennard-Jones solid from molecular dynamics simulations. The pressure and energy data from these simulations have been fitted to a simple functional form (18 parameters) for densities ranging from around 0.94–1.
Free energy of the Lennard-Jones solid
van der Hoef, Martin Anton
2000-01-01
We have determined a simple expression for the absolute Helmholtz free energy of the fcc Lennard-Jones solid from molecular dynamics simulations. The pressure and energy data from these simulations have been fitted to a simple functional form (18 parameters) for densities ranging from around
DREDGED MATERIAL RECLAMATION AT THE JONES ISLAND CONFINED DISPOSAL FACILITY - ITER
In this SITE demonstration, phytoremediation technology was applied to contaminated dredged materials from the Jones Island Confined Disposal Facility (CDF) located in Milwaukee Harbor, Wisconsin. The Jones Island CDF receives dredged materials from normal maintenance of Milwauke...
2010-04-21
..., Atlantic Ocean off of Jones Beach, Wantagh, NY AGENCY: Coast Guard, DHS. ACTION: Notice of proposed... an air show which consist of aircraft performing aerobatic maneuvers over the Atlantic Ocean off of..., which will then become highlighted in blue. In the ``Document Type'' drop down menu select...
Phanerozoic black shales and the Wilson Cycle
Trabucho-Alexandre, J.; Hay, W. W.; de Boer, P. L.
2011-09-01
The spatial and temporal distribution of black shales is related to the development of the environments in which they accumulate and to a propitious combination of environmental variables. Whereas much has been done in recent years to improve our understanding of the mechanisms behind the temporal distribution of black shales in the Phanerozoic, the interpretation of the palaeogeographical distribution of black shales is still dominated by an oversimplistic set of three uniformitarian depositional models that do not capture the complexity and dynamics of environments of black shale accumulation. These three models, the restricted circulation, the (open) ocean oxygen minimum and the continental shelf models, are in fact a uniformitarian simplification of the variety of depositional environments that arise and coexist throughout the course of a basin's Wilson Cycle, i.e. the dynamic sequence of events and stages that characterise the evolution of an ocean basin, from the opening continental rift to the closing orogeny. We examine the spatial distribution of black shales in the context of the Wilson Cycle using examples from the Phanerozoic. It is shown that the geographical distribution of black shales, their position in the basin infill sequence and their nature (e.g. type of organic matter, lithology) depend on basin evolution because the latter controls the development of sedimentary environments where black shales may be deposited.
Precision Holography with Supersymmetric Wilson Loops
Faraggi, Alberto; Silva, Guillermo A; Trancanelli, Diego
2016-01-01
We consider certain 1/4 BPS Wilson loop operators in $SU(N)$ ${\\cal N}=4$ super Yang-Mills theory, whose expectation value can be computed exactly via supersymmetric localization. Holographically, these operators are mapped to fundamental strings in $AdS_5\\times S^5$. The string on-shell action reproduces the large $N$ and large coupling limit of the gauge theory expectation value and, according to the AdS/CFT correspondence, there should also be a precise match between subleading corrections to these limits. We perform a test of such match at next-to-leading order in string theory, by computing the 1-loop determinant of the quantum fluctuations around the classical string configuration. A source of ambiguity, related to ghost zero modes, is removed by comparing our operator with the 1/2 BPS circular Wilson loop. We find perfect agreement between the string theory result and the gauge theory prediction. This successful match, besides being a high precision test of the AdS/CFT correspondence, elucidates some o...
Toward precision holography with supersymmetric Wilson loops
Faraggi, Alberto; Pando Zayas, Leopoldo A.; Silva, Guillermo A.; Trancanelli, Diego
2016-04-01
We consider certain 1/4 BPS Wilson loop operators in SU( N) N=4 supersymmetric Yang-Mills theory, whose expectation value can be computed exactly via supersymmetric localization. Holographically, these operators are mapped to fundamental strings in AdS 5 × S 5. The string on-shell action reproduces the large N and large coupling limit of the gauge theory expectation value and, according to the AdS/CFT correspondence, there should also be a precise match between subleading corrections to these limits. We perform a test of such match at next-to-leading order in string theory, by deriving the spectrum of quantum fluctuations around the classical string solution and by computing the corresponding 1-loop effective action. We discuss in detail the supermultiplet structure of the fluctuations. To remove a possible source of ambiguity in the ghost zero mode measure, we compare the 1/4 BPS configuration with the 1/2 BPS one, dual to a circular Wilson loop. We find a discrepancy between the string theory result and the gauge theory prediction, confirming a previous result in the literature. We are able to track the modes from which this discrepancy originates, as well as the modes that by themselves would give the expected result.
Indiana Jones on tagasi ja näitab, kuidas käituda / Kristiina Davidjants
Davidjants, Kristiina, 1974-
2008-01-01
22 mail esilinastub Steven Spielbergi järjekordne Indiana Jones'i film, kaasstsenaristiks ja produtsendiks George Lucas ja Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull"). Saaga varasemast kolmest filmist
Indiana Jones on tagasi ja näitab, kuidas käituda / Kristiina Davidjants
Davidjants, Kristiina, 1974-
2008-01-01
22 mail esilinastub Steven Spielbergi järjekordne Indiana Jones'i film, kaasstsenaristiks ja produtsendiks George Lucas ja Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull"). Saaga varasemast kolmest filmist
2010-07-26
... Employment and Training Administration Dow Jones & Company, Sharon Pennsylvania Print Plant a Subsidiary of... the TAA petition filed on behalf of workers at Dow Jones & Company, Sharon Pennsylvania Print Plant, a... (Konica). Neither of those relationships exists between Dow Jones & Company, West Middlesex,...
Response to "An Experiment in Method" (J. L. J. Wilson)
Stehlik, Tom
2010-01-01
This article presents the author's response to "An Experiment in Method" by J.L.J. Wilson. In 1960-61 Wilson was invited to give lectures on "modern techniques in adult education" as part of a training school for those involved in the work of developing "Co-operatives for Aborigines" which were sponsored by the…
Density-dependent mass gain by Wilson's Warblers during stopover
Jeffrey F. Kelly; Linda S. DeLay; Deborah M. Finch
2002-01-01
The need restore energetic reserves at stopover sites constrains avian migration ecology. To describe that constraint, we examined relationships among mass gained by Wilson's Warblers (Wilsonia pusilla) during stopover, abundance of Wilson's Warblers (i.e. capture rate), and arthropod abundance during autumn migration. We found that amount...
Woodrow Wilson: Prophet of Peace. Teaching with Historic Places.
Goehner, Thomas B.
This lesson describes President Woodrow Wilson's struggle with and his ultimate failure at achieving lasting world peace through the League of Nations. The lesson focuses on November 23, 1923, the eve of the fifth anniversary of the Armistice that concluded World War I, when a frail and ill Wilson was ready to deliver a commemorative address by…
Analysis of the human Atox 1 homologue in Wilson patients
Institute of Scientific and Technical Information of China (English)
Isabel Simon; Mark Schaefer; Jürgen Reichert; Wolfgang Stremmel
2008-01-01
AIM: To analyze the metallochaperone antioxidant-1 (Atoxl) gene sequence in Wilson disease patients.METHODS: Mutation analysis of the four exons of the Atoxl gene including the intron- exon boundaries was performed in 63 Wilson disease patients by direct sequencing.RESULTS: From 63 selected patients no mutations were identified after the entire coding region including the intron- exon boundaries of Atoxl were sequenced.One known polymorphism within the Atoxl gene (5'UTR-99 T>C) in 31 (49%) of the Wilson patients as well as one previously undescribed variation (5'UTR -68 C>T)in 2 of the Wilson patients could be detected. Statistical analyses revealed that the existence of a variation within the Atoxl- gene showed a tendency towards an earlier onset of the disease.CONCLUSION: Based on the data of this study, no major role can be attributed to Atoxl in the pathophysiology or clinical variation of Wilson disease.
Cusped light-like Wilson loops in gauge theories
Cherednikov, I O; Van der Veken, F F
2012-01-01
We propose and discuss a new approach to the analysis of the correlation functions which contain light-like Wilson lines or loops, the latter being cusped in addition. The objects of interest are therefore the light-like Wilson null-polygons, the soft factors of the parton distribution and fragmentation functions, high-energy scattering amplitudes in the eikonal approximation, gravitational Wilson lines, etc. Our method is based on a generalization of the universal quantum dynamical principle by J. Schwinger and allows one to take care of extra singularities emerging due to light-like or semi-light-like cusps. We show that such Wilson loops obey a differential equation which connects the area variations and renormalization group behavior of those objects and discuss the possible relation between geometrical structure of the loop space and area evolution of the light-like cusped Wilson loops.
BPS Wilson loops in Minkowski spacetime and Euclidean space
Ouyang, Hao; Wu, Jun-Bao; Zhang, Jia-ju
2015-12-01
We give evidence that spacelike BPS Wilson loops do not exist in Minkowski spacetime. We show that spacelike Wilson loops in Minkowski spacetime cannot preserve any supersymmetries, in d = 4 N = 4 super Yang-Mills theory, d = 3 N = 2 super Chern-Simons-matter theory, and d = 3 N = 6 Aharony-Bergman-Jafferis-Maldacena theory. We not only show this using infinite straight lines and circles as examples, but also we give proofs for general curves. We attribute this to the conflicts of the reality conditions of the spinors. However, spacelike Wilson loops do exist in Euclidean space. There are both BPS Wilson loops along infinite straight lines and circular BPS Wilson loops. This is because the reality conditions of the spinors are lost after Wick rotation. The result is reasonable in view of the AdS/CFT correspondence.
BPS Wilson loops in Minkowski spacetime and Euclidean space
Energy Technology Data Exchange (ETDEWEB)
Ouyang, Hao, E-mail: ouyangh@ihep.ac.cn; Wu, Jun-Bao, E-mail: wujb@ihep.ac.cn; Zhang, Jia-ju, E-mail: jjzhang@ihep.ac.cn [Theoretical Physics Division, Institute of High Energy Physics, Chinese Academy of Sciences, 19B Yuquan Rd, 100049, Beijing (China); Theoretical Physics Center for Science Facilities, Chinese Academy of Sciences, 19B Yuquan Rd, 100049, Beijing (China)
2015-12-21
We give evidence that spacelike BPS Wilson loops do not exist in Minkowski spacetime. We show that spacelike Wilson loops in Minkowski spacetime cannot preserve any supersymmetries, in d=4N=4 super Yang–Mills theory, d=3N=2 super Chern–Simons-matter theory, and d=3N=6 Aharony–Bergman–Jafferis–Maldacena theory. We not only show this using infinite straight lines and circles as examples, but also we give proofs for general curves. We attribute this to the conflicts of the reality conditions of the spinors. However, spacelike Wilson loops do exist in Euclidean space. There are both BPS Wilson loops along infinite straight lines and circular BPS Wilson loops. This is because the reality conditions of the spinors are lost after Wick rotation. The result is reasonable in view of the AdS/CFT correspondence.
BPS Wilson loops in Minkowski spacetime and Euclidean space
Energy Technology Data Exchange (ETDEWEB)
Ouyang, Hao; Wu, Jun-Bao; Zhang, Jia-ju [Chinese Academy of Sciences, Theoretical Physics Division, Institute of High Energy Physics, Beijing (China); Chinese Academy of Sciences, Theoretical Physics Center for Science Facilities, Beijing (China)
2015-12-15
We give evidence that spacelike BPS Wilson loops do not exist in Minkowski spacetime. We show that spacelikeWilson loops in Minkowski spacetime cannot preserve any supersymmetries, in d = 4 N = 4 super Yang-Mills theory, d = 3 N = 2 super Chern-Simons-matter theory, and d = 3 N = 6 Aharony-Bergman-Jafferis- Maldacena theory. We not only show this using infinite straight lines and circles as examples, but also we give proofs for general curves. We attribute this to the conflicts of the reality conditions of the spinors. However, spacelike Wilson loops do exist in Euclidean space. There are both BPS Wilson loops along infinite straight lines and circular BPS Wilson loops. This is because the reality conditions of the spinors are lost after Wick rotation. The result is reasonable in view of the AdS/CFT correspondence. (orig.)
Birefringence of cellotape: Jones representation and experimental analysis
Energy Technology Data Exchange (ETDEWEB)
Belendez, Augusto; Frances, Jorge; Neipp, Cristian [Departamento de Fisica, Ingenieria de Sistemas y Teoria de la Senal, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain); Fernandez, Elena [Departamento de Optica, FarmacologIa y Anatomia, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain)], E-mail: a.belendez@ua.es
2010-05-15
In this paper, we analyse a simple experiment to study the effects of polarized light. A simple optical system composed of a polarizer, a retarder (cellotape) and an analyser is used to study the effect on the polarization state of the light which impinges on the setup. The optical system is characterized by means of a Jones matrix, and a simple procedure based on Jones vectors is used to obtain an expression for the intensity after the light passes through the optical system. The light intensity is measured by a photodetector and the expression obtained theoretically is experimentally validated. By fitting the experimental intensity data, the value of the retardation introduced by the retarder can also be obtained.
Experimental approximation of the Jones polynomial with one quantum bit.
Passante, G; Moussa, O; Ryan, C A; Laflamme, R
2009-12-18
We present experimental results approximating the Jones polynomial using 4 qubits in a liquid state nuclear magnetic resonance quantum information processor. This is the first experimental implementation of a complete problem for the deterministic quantum computation with one quantum bit model of quantum computation, which uses a single qubit accompanied by a register of completely random states. The Jones polynomial is a knot invariant that is important not only to knot theory, but also to statistical mechanics and quantum field theory. The implemented algorithm is a modification of the algorithm developed by Shor and Jordan suitable for implementation in NMR. These experimental results show that for the restricted case of knots whose braid representations have four strands and exactly three crossings, identifying distinct knots is possible 91% of the time.
Gauge-origin independent calculations of Jones birefringence
Shcherbin, Dmitry; Thorvaldsen, Andreas J.; Jonsson, Dan; Ruud, Kenneth
2011-10-01
We present the first gauge-origin independent formulation of Jones birefringence at the Hartree-Fock level of theory. Gauge-origin independence is achieved through the use of London atomic orbitals. The implementation is based on a recently proposed atomic orbital-based response theory formulation that allows for the use of both time- and perturbation-dependent basis sets [Thorvaldsen, Ruud, Kristensen, Jørgensen, and Coriani, J. Chem. Phys. 129, 214108 (2008)]. We present the detailed expressions for the response functions entering the Jones birefringence when London atomic orbitals are used. The implementation is tested on a set of polar and dipolar molecules at the Hartree-Fock level of theory. It is demonstrated that London orbitals lead to much improved basis-set convergence, and that the use of small, conventional basis sets may lead to the wrong sign for the calculated birefringence. For large basis sets, London orbitals and conventional basis sets converge to the same results.
Tubo de Lester-Jones: indicações e resultados Lester-Jones tube: indications and results
Directory of Open Access Journals (Sweden)
Walberto Passos Junior
2004-12-01
Full Text Available OBJETIVO: Avaliar as indicações, resultados e complicações advindas do seu uso. MÉTODOS: Avaliaram-se retrospectivamente 25 pacientes submetidos a 27 conjuntivorrinostomias com colocação de tubo de Lester-Jones. Foram estudados os dados do portador, a etiologia da afecção e as complicações que ocorreram no intra e no pós-operatório. Os dados foram avaliados segundo a freqüência de ocorrência. RESULTADOS: O tubo de Lester-Jones foi usado igualmente em ambos os sexos, mais em indivíduos abaixo dos 10 ou acima dos 50 anos de idade. As causas mais freqüentes para utilização foram a idiopática ou a agenesia congênita de pontos e canalículos. Houve melhora dos sintomas em 88% dos pacientes. Complicações ocorreram em 59,25% dos casos, dentre as quais: extrusão (40,74% e a migração (14,8% do tubo. CONCLUSÃO: Apesar das complicações observadas, o índice de cura com a utilização do tubo de Lester-Jones é alto, sendo boa opção para o tratamento das obstruções lacrimais altas.PURPOSE: To evaluate the results and the complications occurring with this procedure. METHODS: The authors retrospectively reviewed charts of 25 patients (27 lacrimal viers with upper lacrimal system obstruction who underwent conjunctivorhinostomy and Lester-Jones tube bypass. The patients were evaluated according to gender, causative factors and the com plications during and after surgery. The data were submitted to statistical analysis. RESULTS: The Lester-Jones bypass tube was used in both sexes and most frequently in patients under 10 or above 50 years. The most common obstructive factor was unknown and congenital agenesis. Eighty-eight per cent of the patients had no epiphora at the end of the treatment. Complications occurred in 59.25% of the patients, most of them related to tube extrusion (40.74% or migration (14.8%. The authors concluded that the Lester-Jones bypass tube is a good option to treat the upper lacrimal obstruction, in spite
The Farrell-Jones Isomorphism Conjecture in K-Theory
Morteo, Marcelo Gomez
2012-01-01
We prove that the Farrell-Jones isomorphism conjecture for non connective K theory for a discrete group G and a coefficient ring R holds true if G belongs to the class of groups acting on trees under certain conditions on G and if R is either regular or hereditary, depending on the structure of G. It is known that these groups verify the isomorphism conjecture if finitely generated for any coefficient ring, but in this article G may not be finitely generated.
Wilson Dslash Kernel From Lattice QCD Optimization
Energy Technology Data Exchange (ETDEWEB)
Joo, Balint [Jefferson Lab, Newport News, VA; Smelyanskiy, Mikhail [Parallel Computing Lab, Intel Corporation, California, USA; Kalamkar, Dhiraj D. [Parallel Computing Lab, Intel Corporation, India; Vaidyanathan, Karthikeyan [Parallel Computing Lab, Intel Corporation, India
2015-07-01
Lattice Quantum Chromodynamics (LQCD) is a numerical technique used for calculations in Theoretical Nuclear and High Energy Physics. LQCD is traditionally one of the first applications ported to many new high performance computing architectures and indeed LQCD practitioners have been known to design and build custom LQCD computers. Lattice QCD kernels are frequently used as benchmarks (e.g. 168.wupwise in the SPEC suite) and are generally well understood, and as such are ideal to illustrate several optimization techniques. In this chapter we will detail our work in optimizing the Wilson-Dslash kernels for Intel Xeon Phi, however, as we will show the technique gives excellent performance on regular Xeon Architecture as well.
Global Wilson-Fisher fixed points
Jüttner, Andreas; Litim, Daniel F.; Marchais, Edouard
2017-08-01
The Wilson-Fisher fixed point with O (N) universality in three dimensions is studied using the renormalisation group. It is shown how a combination of analytical and numerical techniques determine global fixed points to leading order in the derivative expansion for real or purely imaginary fields with moderate numerical effort. Universal and non-universal quantities such as scaling exponents and mass ratios are computed, for all N, together with local fixed point coordinates, radii of convergence, and parameters which control the asymptotic behaviour of the effective action. We also explain when and why finite-N results do not converge pointwise towards the exact infinite-N limit. In the regime of purely imaginary fields, a new link between singularities of fixed point effective actions and singularities of their counterparts by Polchinski are established. Implications for other theories are indicated.
ABJM Wilson Loops in Arbitrary Representations
Hatsuda, Yasuyuki; Moriyama, Sanefumi; Okuyama, Kazumi
2013-01-01
We study vacuum expectation values (VEVs) of circular half BPS Wilson loops in arbitrary representations in ABJM theory. We find that those in hook representations are reduced to elementary integrations thanks to the Fermi gas formalism, which are accessible from the numerical studies similar to the partition function in the previous studies. For non-hook representations, we show that the VEVs in the grand canonical formalism can be exactly expressed as determinants of those in the hook representations. Using these facts, we can study the instanton effects of the VEVs in various representations. Our results are consistent with the worldsheet instanton effects studied from the topological string and a prescription to include the membrane instanton effects by shifting the chemical potential, which has been successful for the partition function.
Phenotypic convergence of Menkes and Wilson disease.
Bansagi, Boglarka; Lewis-Smith, David; Pal, Endre; Duff, Jennifer; Griffin, Helen; Pyle, Angela; Müller, Juliane S; Rudas, Gabor; Aranyi, Zsuzsanna; Lochmüller, Hanns; Chinnery, Patrick F; Horvath, Rita
2016-12-01
Menkes disease is an X-linked multisystem disorder with epilepsy, kinky hair, and neurodegeneration caused by mutations in the copper transporter ATP7A. Other ATP7A mutations have been linked to juvenile occipital horn syndrome and adult-onset hereditary motor neuropathy.(1,2) About 5%-10% of the patients present with "atypical Menkes disease" characterized by longer survival, cerebellar ataxia, and developmental delay.(2) The intracellular copper transport is regulated by 2 P type ATPase copper transporters ATP7A and ATP7B. These proteins are expressed in the trans-Golgi network that guides copper to intracellular compartments, and in copper excess, it relocates copper to the plasma membrane to pump it out from the cells.(3)ATP7B mutations cause Wilson disease with dystonia, ataxia, tremor, and abnormal copper accumulation in the brain, liver, and other organs.(4).
Wilson Fermions with Four Fermion Interactions
Rantaharju, Jarno; Hietanen, Ari; Pica, Claudio; Sannino, Francesco
2015-01-01
We present a lattice study of a four fermion theory, known as Nambu Jona-Lasinio (NJL) theory, via Wilson fermions. Four fermion interactions naturally occur in several extensions of the Standard Model as a low energy parameterisation of a more fundamental theory. In models of dynamical electroweak symmetry breaking these operators, at an effective level, are used to endow the Standard Model fermions with masses. Furthermore these operators, when sufficiently strong, can drastically modify the fundamental composite dynamics by, for example, turning a strongly coupled infrared conformal theory into a (near) conformal one with desirable features for model building. As first step, we study spontaneous chiral symmetry breaking for the lattice version of the NJL model.
ABJM Wilson loops in arbitrary representations
Energy Technology Data Exchange (ETDEWEB)
Hatsuda, Yasuyuki [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Theory Group; Tokyo Institute of Technology (Japan). Dept. of Physics; Honda, Masazumi [High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki (Japan); Moriyama, Sanefumi [Nagoya Univ. (Japan). Kobayashi Maskawa Inst. and Graduate School of Mathematics; Okuyama, Kazumi [Shinshu Univ., Matsumoto, Nagano (Japan). Dept. of Physics
2013-06-15
We study vacuum expectation values (VEVs) of circular half BPS Wilson loops in arbitrary representations in ABJM theory. We find that those in hook representations are reduced to elementary integrations thanks to the Fermi gas formalism, which are accessible from the numerical studies similar to the partition function in the previous studies. For non-hook representations, we show that the VEVs in the grand canonical formalism can be exactly expressed as determinants of those in the hook representations. Using these facts, we can study the instanton effects of the VEVs in various representations. Our results are consistent with the worldsheet instanton effects studied from the topological string and a prescription to include the membrane instanton effects by shifting the chemical potential, which has been successful for the partition function.
Mueller-Jones Matrix measurement in material identification
Xu, Jiang; Qian, Weixian; Wang, Xiao
2016-09-01
The uniformity of lattice arrangement plays an important role in industrial processing, science and technology studies and environmental pollution detection. However, there are very little papers to study surface structure by depolarization characteristics. In order to improve the efficiency and accuracy of material identification system by polarization technology, we developed a new method to decompose the Mueller matrix, we studied the mechanism of the scattering of electromagnetic wave, and analyzed the relationship between the characteristics of depolarization and mechanism of scattering. We used the Jones Matrix and Mueller Matrix to set up the physical model, and decomposed the Mueller-Jones Matrix by the characteristics of polarization, then got the depolarization coefficients (ωd) of the surfaces of the samples. By using this theory, we deduced the relation formula of Mueller matrix, Mueller-Jones matrix and Isotropic-Depolarizer matrix. Based on the polarized characteristics of the samples, we analyzed design method of material identification system and gave the results of the experimental test. Finally, we applied the theory of Fresnel formulas to verify the theoretical model. From the results, we found that the depolarization coefficients of the samples' surfaces were related to the scattering, and in the whole measurement process, the depolarization coefficients of the samples were far different; the method could easily to distinguish the metal and nonmetal, and more quickly to analyze the surface roughness of the samples. Therefore, the depolarization technology had a great application value, and the paper had very important significance on the development of surface structure study.
A Viola-Jones based hybrid face detection framework
Murphy, Thomas M.; Broussard, Randy; Schultz, Robert; Rakvic, Ryan; Ngo, Hau
2013-12-01
Improvements in face detection performance would benefit many applications. The OpenCV library implements a standard solution, the Viola-Jones detector, with a statistically boosted rejection cascade of binary classifiers. Empirical evidence has shown that Viola-Jones underdetects in some instances. This research shows that a truncated cascade augmented by a neural network could recover these undetected faces. A hybrid framework is constructed, with a truncated Viola-Jones cascade followed by an artificial neural network, used to refine the face decision. Optimally, a truncation stage that captured all faces and allowed the neural network to remove the false alarms is selected. A feedforward backpropagation network with one hidden layer is trained to discriminate faces based upon the thresholding (detection) values of intermediate stages of the full rejection cascade. A clustering algorithm is used as a precursor to the neural network, to group significant overlappings. Evaluated on the CMU/VASC Image Database, comparison with an unmodified OpenCV approach shows: (1) a 37% increase in detection rates if constrained by the requirement of no increase in false alarms, (2) a 48% increase in detection rates if some additional false alarms are tolerated, and (3) an 82% reduction in false alarms with no reduction in detection rates. These results demonstrate improved face detection and could address the need for such improvement in various applications.
Quantum algorithms for virtual Jones polynomials via Thistlethwaite theorems
Vélez, Mario; Ospina, Juan
2010-04-01
Recently a quantum algorithm for the Jones polynomial of virtual links was proposed by Kauffman and Dye via the implementation of the virtual braid group in anyonic topological quantum computation when the virtual crossings are considered as generalized swap gates. Also recently, a mathematical method for the computation of the Jones polynomial of a given virtual link in terms of the relative Tuttle polynomial of its face (Tait) graph with some suitable variable substitutions was proposed by Diao and Hetyei. The method of Diao and Hetyei is offered as an alternative to the ribbon graph approach according to which the Tutte polynomial of a given virtual link is computed in terms of the Bollobás- Riordan polynomial of the corresponding ribbon graph. The method of Diao and Hetyei can be considered as an extension of the celebrated Thistlethwaite theorem according to which invariant polynomials for knots and links are derived from invariant polynomials for graphs. Starting from these ideas we propose a quantum algorithm for the Jones polynomial of a given virtual link in terms of the generalized Tutte polynomials by exploiting the Thistlethwaite theorem and the Kauffman algorithm . Our method is claimed as the quantum version of the Diao-Hetyei method. Possible supersymmetric implementations of our algortihm are discussed jointly with its formulations using topological quantum lambda calculus.
Wilson-Cowan Equations for Neocortical Dynamics.
Cowan, Jack D; Neuman, Jeremy; van Drongelen, Wim
2016-12-01
In 1972-1973 Wilson and Cowan introduced a mathematical model of the population dynamics of synaptically coupled excitatory and inhibitory neurons in the neocortex. The model dealt only with the mean numbers of activated and quiescent excitatory and inhibitory neurons, and said nothing about fluctuations and correlations of such activity. However, in 1997 Ohira and Cowan, and then in 2007-2009 Buice and Cowan introduced Markov models of such activity that included fluctuation and correlation effects. Here we show how both models can be used to provide a quantitative account of the population dynamics of neocortical activity.We first describe how the Markov models account for many recent measurements of the resting or spontaneous activity of the neocortex. In particular we show that the power spectrum of large-scale neocortical activity has a Brownian motion baseline, and that the statistical structure of the random bursts of spiking activity found near the resting state indicates that such a state can be represented as a percolation process on a random graph, called directed percolation.Other data indicate that resting cortex exhibits pair correlations between neighboring populations of cells, the amplitudes of which decay slowly with distance, whereas stimulated cortex exhibits pair correlations which decay rapidly with distance. Here we show how the Markov model can account for the behavior of the pair correlations.Finally we show how the 1972-1973 Wilson-Cowan equations can account for recent data which indicates that there are at least two distinct modes of cortical responses to stimuli. In mode 1 a low intensity stimulus triggers a wave that propagates at a velocity of about 0.3 m/s, with an amplitude that decays exponentially. In mode 2 a high intensity stimulus triggers a larger response that remains local and does not propagate to neighboring regions.
PERBANDINGAN TEORI PERILAKU PENCARIAN INFORMASI MENURUT ELLIS, WILSON DAN KUHLTHAU
Directory of Open Access Journals (Sweden)
Widiyastuti Widiyastuti
2016-10-01
Full Text Available AbstrakSetiap pemustaka memiliki perilaku pencarian informasi yang berbeda sesuai dengan kebutuhannya. Perilaku pencarian informasi mengacu kepada bagaimana seseorang mencari dan meramu suatu informasi yang diperolehnya. Setidaknya terdapat tiga teori perilaku pencarian informasi, yaitu teori-teori yang dikemukakan oleh Ellis, Wilson dan Kuhlthau. Ketiga tokoh tersebut mencetuskan teori yang dapat digunakan untuk mengkaji perilaku pencarian informasi pemustaka. Tulisan ini bertujuan untuk membandingkan ketia teori tersebut. Hasil analisa menunjukkan bahwa terdapat enam perbedaan dari teori Ellis, Wilson dan Kuhlthau dan satu kesamaan antara teori Ellis dan Wilson, tetapi masih terbuka kemungkinan ditemukan perbedaan lainnya.Kata Kunci: Pencarian Informasi, Ellis, Wilson, Kuhlthau.AbstractEllis, Wilson and Kuhlthau are figures in information study who propose their theories about information seeking behavior. Their theories are applied as a guide in doing study regards users in library. Users studies is needed to know users’ characteristics so that library management would arrange suitable collection and provide suitable facility for the users. Information seeking theory according to Ellis, Wilson and Kuhlthau are different but connected. There are six differences between those theories but one similarity nonetheles there is possibility of other differences among their theories. Keywords: Information Seeking, Ellis, Wilson, Kuhlthau
Molecular studies of ceruloplasmin deficiency in Wilson's disease.
Czaja, M J; Weiner, F R; Schwarzenberg, S J; Sternlieb, I; Scheinberg, I H; Van Thiel, D H; LaRusso, N F; Giambrone, M A; Kirschner, R; Koschinsky, M L
1987-10-01
Deficiency of serum ceruloplasmin is a characteristic biochemical abnormality of Wilson's disease, although the mechanism of this finding is unknown. Ceruloplasmin messenger RNA (mRNA) levels were therefore examined in five patients with Wilson's disease and five controls with other types of hepatic disease. Northern and dot blot hybridizations showed that detectable ceruloplasmin mRNA was present in all of the patients with Wilson's disease, including one patient with no detectable serum ceruloplasmin. However, the ceruloplasmin mRNA levels in the Wilson's disease patients were only 33% that of controls (P less than 0.001). In contrast, albumin mRNA levels in the Wilson's disease patients averaged 161% that of controls. In an attempt to better delineate the level of gene expression responsible for this decrease in ceruloplasmin mRNA, the nuclear run-on assay was used to analyze transcriptional rates. The amount of ceruloplasmin gene transcription in four Wilson's patients was decreased to 44% that of three controls. These results indicate that the diminished serum ceruloplasmin levels in patients with Wilson's disease are due at least in part to a decrease in ceruloplasmin gene transcription.
Energy Technology Data Exchange (ETDEWEB)
Ben-Itzhak, Itzik (Itzhak) [J.R. Macdonald Laboratory, Physics Department, Kansas State University; Carnes, Kevin D. [J.R. Macdonald Laboratory, Physics Department, Kansas State University; Cocke, C. Lew [J.R. Macdonald Laboratory, Physics Department, Kansas State University; Fehrenbach, Charles W. [J.R. Macdonald Laboratory, Physics Department, Kansas State University; Kumarappan, Vinod [PULSAR: A High-Repetition-Rate, High-Power, CE Phase-Locked Laser for the J.R. Macdonald Laboratory at Kansas State University; Rudenko, Artem [J.R. Macdonald Laboratory, Physics Department, Kansas State University; Trallero, Carlos [J.R. Macdonald Laboratory, Physics Department, Kansas State University
2014-05-09
This instrumentation grant funded the development and installation of a state-of-the-art laser system to be used for the DOE funded research at the J.R. Macdonald Laboratory at Kansas State University. Specifically, we purchased a laser based on the KMLABs Red-Dragon design, which has a high repetition rate of 10-20 kHz crucial for multi-parameter coincidence measurements conducted in our lab. This laser system is carrier-envelope phase (CEP) locked and provides pulses as short as 21 fs directly from the amplifier (see details below). In addition, we have developed a pulse compression setup that provides sub 5 fs pulses and a CEP tagging capability that allows for long measurements of CEP dependent processes.
QCD Factorization, Wilson Loop Space and Unintegrated Gluon Distributions
Cherednikov, Igor O.
2017-03-01
Currently available operator definitions of gauge-invariant unintegrated (transverse momentum dependent) gluon density function available are briefly overviewed, with emphasis on the structure of the associated Wilson lines. A gauge-invariant generating function with maximal path-dependence is proposed, which, as distinct from the common methodology, is based on arbitrary Wilson loops with no reference to any factorization scheme. After the local area differentiation defined in the Wilson loop space, this object can be used to define fully unintegrated gluon distribution functions in a way potentially suitable for the lattice simulations.
Accuracy analysis of wilson-θ method with modified acceleration%加速度修正的Wilson-θ法的精度分析
Institute of Scientific and Technical Information of China (English)
方德平; 王全凤
2010-01-01
Wilson-θ法分为加速度未经过和经过t+△t时刻动力平衡方程修正的Wilson-θ①法和Wilson-θ②法.Wilson-θ①法是无条件稳定的,而Wilson-θ②法不再是无条件稳定的.计算精度分析表明:Wilson-θ②法对计算精度的提高不明显;其稳定的范围和计算精度均小于线性加速度法,不宜采用.
Novel BPS Wilson loops in three-dimensional quiver Chern-Simons-matter theories
Ouyang, Hao; Wu, Jun-Bao; Zhang, Jia-ju
2016-02-01
We show that generic three-dimensional N = 2 quiver super Chern-Simons-matter theories admit Bogomol'nyi-Prasad-Sommerfield (BPS) Drukker-Trancanelli (DT) type Wilson loops. We investigate both Wilson loops along timelike infinite straight lines in Minkowski spacetime and circular Wilson loops in Euclidean space. In Aharnoy-Bergman-Jafferis-Maldacena theory, we find that generic BPS DT type Wilson loops preserve the same number of supersymmetries as Gaiotto-Yin type Wilson loops. There are several free parameters for generic BPS DT type Wilson loops in the construction, and supersymmetry enhancement for Wilson loops happens for special values of the parameters.
Novel BPS Wilson loops in three-dimensional quiver Chern–Simons-matter theories
Directory of Open Access Journals (Sweden)
Hao Ouyang
2016-02-01
Full Text Available We show that generic three-dimensional N=2 quiver super Chern–Simons-matter theories admit Bogomol'nyi–Prasad–Sommerfield (BPS Drukker–Trancanelli (DT type Wilson loops. We investigate both Wilson loops along timelike infinite straight lines in Minkowski spacetime and circular Wilson loops in Euclidean space. In Aharnoy–Bergman–Jafferis–Maldacena theory, we find that generic BPS DT type Wilson loops preserve the same number of supersymmetries as Gaiotto–Yin type Wilson loops. There are several free parameters for generic BPS DT type Wilson loops in the construction, and supersymmetry enhancement for Wilson loops happens for special values of the parameters.
A note on multiply wound BPS Wilson loops in ABJM
Bianchi, Marco S
2016-01-01
We consider BPS Wilson loops in planar ABJM theory, wound multiple times around the great circle. We compute the expectation value of the 1/6-BPS and 1/2-BPS Wilson loops to three- and two-loop order in perturbation theory, respectively, dealing with the combinatorics of multiple winding via recursive relations. For the 1/6-BPS Wilson loop we perform the computation at generic framing and at framing 1 we find agreement with the localization result. For the 1/2-BPS Wilson loop we compute the expectation value at trivial framing and by comparison with the matrix model expression we extract the framing dependence of the fermion diagrams.
Copper removal strategies for Wilson's disease crisis in the ICU.
Reynolds, H V; Talekar, C R; Bellapart, J; Leggett, B A; Boots, R J
2014-03-01
Wilson's disease is a rare, inherited, autosomal recessive disorder of copper metabolism which leads to an accumulation of copper in body tissues. If a patient develops a Wilson's crisis, mortality can approach 100%. The treatment of such patients is mostly organ support but a possible treatment goal is to try to rapidly remove copper from their system. We performed a literature search on methods for de-coppering strategies for patients in intensive care with known Wilson's disease. We found 11 case reports where therapeutic plasma exchange was used and six case reports where various forms of albumin dialysis were used as techniques for rapidly reducing serum copper levels. To date, the case reports are encouraging that therapeutic plasma exchange and albumin dialysis can either delay or prevent the need for liver transplantation in patients with fulminant hepatic failure due to Wilson's disease. However, these case reports are mainly in the paediatric or young adult population, thus further studies in adults are warranted.
Ten-Year Study of a Wilson's Disease Dysarthric.
Day, Linda Susan; Parnell, Martha M.
1987-01-01
The 10-year longitudinal case study describes the history, speech therapy program, and treatment results for an adult male with Wilson's disease, a genetically based metabolic progressive neurological disorder which includes severe speech problems. (DB)
Pyoderma Gangrenosum-A New Manifestation of Wilson Disease?
Freg, George Naiem Ibrahiem; Shah, Venisha; Nagral, Aabha; Jhaveri, Ajay
2016-03-01
Seventeen year old girl, a known case of Wilson disease presented to us with a non-healing skin ulcer followed by appearance of jaundice, ascites and progressive fatigue of 1 month duration. She was diagnosed to have Wilson disease 5 years back and had been well controlled on d-penicillamine. On enquiry, she was found to be noncompliant with her medication in the preceding 6 months. On examination, she had severe pallor, icterus with moderate ascites and oedema feet. Investigations revealed severe haemolytic anemia and deranged liver function. The lesion was diagnosed to be pyoderma gangrenosum on skin biopsy. The appearance of a cutaneous lesion followed by deterioration in the liver disease and hemolysis suggested uncontrolled Wilson disease as the triggering factor. Chelation therapy improved her haemoglobin and liver function as well as led to healing of the ulcer. We describe pyoderma gangrenosum as a new manifestation of Wilson disease.
A note on multiply wound BPS Wilson loops in ABJM
Bianchi, Marco S.
2016-09-01
We consider BPS Wilson loops in planar ABJM theory, wound multiple times around the great circle. We compute the expectation value of the 1/6-BPS and 1/2-BPS Wilson loops to three- and two-loop order in perturbation theory, respectively, dealing with the combinatorics of multiple winding via recursive relations. For the 1/6-BPS Wilson loop we perform the computation at generic framing and at framing 1 we find agreement with the localization result. For the 1/2-BPS Wilson loop we compute the expectation value at trivial framing and by comparison with the matrix model expression we extract the framing dependence of the fermion diagrams.
Minn fuq l-ixkaffa : program 3 : Jacqueline Wilson
Grech, Sergio
2006-01-01
Sergio Grech together with author Trevor Zahra, look into the works of 17 famous world renowned authors, such as Charles Dickens, Paolo Coelho, Ha Jin, Jacqueline Wilson, William Shakespeare, Philip Pullman, Kundera and Kazuo Ishiguro just to mention a few.
A new approach to piecewise linear Wilson lines
Van der Veken, Frederik F
2014-01-01
Wilson lines are key objects in many QCD calculations. They are parallel transporters of the gauge field that can be used to render non-local operator products gauge invariant, which is especially useful for calculations concerning validation of factorization schemes and in calculations for constructing or modelling parton density functions. We develop an algorithm to express Wilson lines that are defined on piecewise linear paths in function of their Wilson segments, reducing the number of diagrams needed to be calculated. We show how different linear path topologies can be related using their color structure. This framework allows one to easily switch results between different Wilson line structures, which is helpful when testing different structures against each other, e.g. when checking universality properties of non-perturbative objects.
Woodrow Wilson Fellows--Who Are They Now?
Rein, Richard K.
1975-01-01
The Woodrow Wilson Senior Fellows are prominent leaders in business and government that are sent to college campuses for a week instead of a one-night lecture. This program has proved to be immensely popular on campuses. (PG)
Exact results for Wilson loops in orbifold ABJM theory
Ouyang, Hao; Wu, Jun-Bao; Zhang, Jia-Ju
2016-08-01
We investigate the exact results for circular 1/4 and 1/2 BPS Wilson loops in the d = 3 mathcal = 4 super Chern-Simons-matter theory that could be obtained by orbifolding Aharony-Bergman-Jafferis-Maldacena (ABJM) theory. The partition function of the mathcal = 4 orbifold ABJM theory has been computed previously in the literature. In this paper, we re-derive it using a slightly different method. We calculate the vacuum expectation values of the circular 1/4 BPS Wilson loops in fundamental representation and of circular 1/2 BPS Wilson loops in arbitrary representations. We use both the saddle point approach and Fermi gas approach. The results for Wilson loops are in accord with the available gravity results. Supported by NSFC (11222549, 11575202), K. C. Wong Education Foundation and Youth Innovation Promotion Association of CAS (2011016)
Four crystal forms of a Bence-Jones protein
Energy Technology Data Exchange (ETDEWEB)
Makino, Debora L.; Henschen-Edman, Agnes H.; McPherson, Alexander, E-mail: amcphers@uci.edu [Molecular Biology and Biochemistry, University of California, Irvine, 560 Steinhaus Hall, Irvine, CA 92697-3900 (United States)
2005-01-01
Four crystal forms have been grown and characterized by X-ray diffraction of a Bence-Jones protein collected from the urine of a multiple myeloma patient more than 40 y ago. The trigonal crystal form may shed some light on the formation of fibrils common to certain storage diseases. Four crystal forms have been grown and characterized by X-ray diffraction of a Bence-Jones protein collected from the urine of a multiple myeloma patient more than 40 years ago. Closely related tetragonal and orthorhombic forms belonging to space groups P4{sub 3}2{sub 1}2 and P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = b = 68.7, c = 182.1 and a = 67.7, b = 69.4, c = 87.3 Å, diffract to 1.5 and 1.9 Å, respectively. Two closely related trigonal forms, both belonging to space group P3{sub 1}21 with unit-cell parameters a = b = 154.3 Å but differing by a doubling of the c axis, one 46.9 Å and the other 94.0 Å, diffract to 2.9 and 2.6 Å resolution, respectively. The trigonal crystal of short c-axis length shows a positive indication of twinning. The trigonal crystal of longer c axis, which appeared only after eight months of incubation at room temperature, is likely to be composed of proteolytically degraded molecules and unlike the other crystal forms contains two entire Bence-Jones dimers in the asymmetric unit. This latter crystal form may shed some light on the formation of fibrils common to certain storage diseases.
Universal properties of Wilson loop operators in large N QCD
Narayanan, R
2008-01-01
Eigenvalues of a Wilson loop operator are gauge invariant and their distribution undergoes a transition at infinite N as the size of the loop is changed. We study this transition using the average characteristic polynomial associated with the Wilson loop operator. We derive the scaling function in a certain double scaling limit for two dimensional QCD and hypothesize that the transition in three and four dimensional QCD are in the same universality class. Numerical evidence for this hypothesisis provided in three dimensions
Morita Duality and Noncommutative Wilson Loops in Two Dimensions
Cirafici, M; Seminara, D; Szabó, R J; Cirafici, Michele; Griguolo, Luca; Seminara, Domenico; Szabo, Richard J.
2005-01-01
We describe a combinatorial approach to the analysis of the shape and orientation dependence of Wilson loop observables on two-dimensional noncommutative tori. Morita equivalence is used to map the computation of loop correlators onto the combinatorics of non-planar graphs. Several nonperturbative examples of symmetry breaking under area-preserving diffeomorphisms are thereby presented. Analytic expressions for correlators of Wilson loops with infinite winding number are also derived and shown to agree with results from ordinary Yang-Mills theory.
Calculating osmotic pressure according to nonelectrolyte Wilson nonrandom factor model.
Li, Hui; Zhan, Tingting; Zhan, Xiancheng; Wang, Xiaolan; Tan, Xiaoying; Guo, Yiping; Li, Chengrong
2014-08-01
Abstract The osmotic pressure of NaCl solutions was determined by the air humidity in equilibrium (AHE) method. The relationship between the osmotic pressure and the concentration was explored theoretically, and the osmotic pressure was calculated according to the nonelectrolyte Wilson nonrandom factor (N-Wilson-NRF) model from the concentration. The results indicate that the calculated osmotic pressure is comparable to the measured one.
Sleep disturbance in Mowat-Wilson syndrome.
Evans, Elizabeth; Mowat, David; Wilson, Meredith; Einfeld, Stewart
2016-03-01
Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome caused by a heterozygous mutation or deletion of the ZEB2 gene. It is characterized by a distinctive facial appearance in association with intellectual disability (ID) and variable other features including agenesis of the corpus callosum, seizures, congenital heart defects, microcephaly, short stature, hypotonia, and Hirschsprung disease. The current study investigated sleep disturbance in people with MWS. In a series of unstructured interviews focused on development and behaviors in MWS, family members frequently reported sleep disturbance, particularly early-morning waking and frequent night waking. The Sleep Disturbance Scale for Children (SDSC) was therefore administered to a sample of 35 individuals with MWS, along with the Developmental Behaviour Checklist (DBC) to measure behavioral and emotional disturbance. A high level of sleep disturbance was found in the MWS sample, with 53% scoring in the borderline range and 44% in the clinical disorder range for at least one subscale of the SDSC. Scores were highest for the Sleep-wake transition disorders subscale, with 91% of participants reaching at least the borderline disorder range. A significant positive association was found between total scores on the SDSC and the DBC Total Behaviour Problem Score. These results suggest that sleep disorders should be screened for in people with MWS, and where appropriate, referrals to sleep specialists made for management of sleep problems.
Mowat-Wilson syndrome: A case report
Directory of Open Access Journals (Sweden)
Čuturilo Goran
2009-01-01
Full Text Available Introduction. Mowat-Wilson syndrome (MWS is characterised by severe mental retardation and multiple congenital anomalies. Key features for diagnosis are specific facial dysmorphism with uplifted ear lobes and Hirschsprung's disease. Ganglionic disorders of the colon, both the number of ganglion cells and the length of the aganglionic segment vary significantly in these patients. The disease is caused by ZFHX1B gene mutation. The management of MWS is symptomatic. Case outline. We report a four-year old boy with mental retardation, specific facial dysmorphy and multiple anomalies. During prenatal follow-up intrauterine growth retardation was revealed. Karyotype was normal. Clinical findings showed that growth and mental retardation, gastrointestinal disturbance and heart defect were predominant. A gastrostoma was inserted. Hypoganglionosis of the colon caused severe obstipation. He had a severe stenosis of the pulmonary artery and was a candidate for cardiac surgery. There were several attempts to establish diagnosis, but so far, without results. Conclusion. Hirschsprung's disease/hypoganglionosis of the colon associated with other congenital anomalies or mental retardation require evaluation for dysmorphic syndromes. One of them is MWS, presented in this report.
Hopping in a supercooled binary Lennard-Jones liquid
DEFF Research Database (Denmark)
Schrøder, Thomas; Dyre, Jeppe
1998-01-01
A binary LennardJones liquid has been investigated by molecular dynamics at equilibrium supercooled conditions. At the lowest temperature investigated, hopping is present in the system as indicated by a secondary peak in 4r2Gs(r,t), where Gs(r,t) is the van Hove self correlation function....... To examine the dynamics of the system, we consider transitions between the inherent structures (local minima in the potential energy) along the trajectory. We conclude that the plateau in the mean square displacement found at lower temperatures is indeed a result of particles being trapped in local "cages...
The Kauffman bracket and the Jones polynomial in quantum gravity
Griego, J R
1995-01-01
An analysis of the action of the Hamiltonian constraint of quantum gravity on the Kauffman bracket and Jones knot polynomials is proposed. It is explicitely shown that the Kauffman bracket is a formal solution of the Hamiltonian constraint with cosmological constant (\\Lambda) to third order in \\Lambda. The calculation is performed in the extended loop representation of quantum gravity. The analysis makes use of the analytical expressions of the knot invariants in terms of the two and three point propagators of the Chern-Simons theory. Some particularities of the extended loop calculus are considered and the implications of the results to the case of the conventional loop representation are discussed.
Accurate Critical Parameters for the Modified Lennard-Jones Model
Okamoto, Kazuma; Fuchizaki, Kazuhiro
2017-03-01
The critical parameters of the modified Lennard-Jones system were examined. The isothermal-isochoric ensemble was generated by conducting a molecular dynamics simulation for the system consisting of 6912, 8788, 10976, and 13500 particles. The equilibrium between the liquid and vapor phases was judged from the chemical potential of both phases upon establishing the coexistence envelope, from which the critical temperature and density were obtained invoking the renormalization group theory. The finite-size scaling enabled us to finally determine the critical temperature, pressure, and density as Tc = 1.0762(2), pc = 0.09394(17), and ρc = 0.331(3), respectively.
The Double Jones Birefringence in Magneto-electric Medium
Mahmood, Waqas
2014-01-01
In this paper, the Maxwell's equations for the tensorial magneto-electric (ME) medium have been solved which in fact is the extension of anisotropic nonmagnetic medium. All of the dielectric permittivity, magnetic permeability and the ME tensors are considered. The transverse polarization is shown explicitly and the propagation of electromagnetic wave in the ME medium is found to have the Double Jones Birefringence. We also find the condition of D'yakonov surface wave for magneto-isotropic but with ME anisotropic medium. Especially when the incident angle is $\\frac{\\pi}{4}$, it may be measurable in principle.
A Unified Model of All Generalizations from the Jones Polynomial
Institute of Scientific and Technical Information of China (English)
QIAN Shang-Wu; GU Zhi-Yu
2001-01-01
From the basic properties of skein systems, we build a generalized tangle algebra (GTA). The elements of GTA are four basic tangles. There are three operations, which are connection, splicing and scalar multiplication. From GTA we derive two generalized recursion formulae (GRF) and prove the existence of a generalized skein relation which satisfies GRF. The obtained generalized skein relation epitomizes all generalizations from the Jones polynomial and thus forms a unified model. Two important topological parameters, twisting measure and loop values, appear explicitly in the expressions of the unified model, and this fact greatly simplifies the operations.
Transpose symmetry of the Jones matrix and topological phases.
Bhandari, Rajendra
2008-04-15
The transmission Jones matrix of an arbitrary stack of reciprocal plane-parallel plates that has been turned through 180 degrees about an axis in the plane of the stack is, in an appropriate basis, the transpose of the transmission matrix of the unturned slab with a change in the sign of the off-diagonal elements. We prove this convention-free result for the case where reflection at the interfaces can be ignored and use it to devise an experimental scheme to separate isotropic and topological phase changes in a reciprocal optical medium.
Advanced Jones calculus for the classification of periodic metamaterials
Menzel, Christoph; Rockstuhl, Carsten; Lederer, Falk
2010-11-01
By relying on an advanced Jones calculus, we analyze the polarization properties of light upon propagation through metamaterial slabs in a comprehensive manner. Based on symmetry considerations, we show that all periodic metamaterials may be divided into five different classes only. It is shown that each class differently affects the polarization of the transmitted light and sustains different eigenmodes. We show how to deduce these five classes from symmetry considerations and provide a simple algorithm that can be applied to decide to which class a given metamaterial belongs by measuring only the transmitted intensities.
Obituary: Peter Robert Wilson, 1929-2007
Snodgrass, Herschel B.
2009-01-01
It is with great sadness that I report the passing of Peter Robert Wilson, a well-known and well-loved figure in the solar physics community. Peter was on the faculty of the Department of Applied Mathematics at the University of Sydney for 39 years, and Chair of the department for 24 of these years. He was the author or co-author of more than 80 scientific research papers and a book, Solar and Stellar Activity Cycles (1994), published by Cambridge University Press. He died suddenly of a heart attack, at his home in Glebe, Australia, in the early morning of 11 November 2007. Peter was an organizer of, and participant in, many international conferences and workshops. He traveled extensively, holding visiting appointments at the University of Colorado (JILA), at Cambridge University, at the College de France (Paris), and at the California Institute of Technology [CalTech]. Most of his work was in the field of solar physics, but he also did some work on the philosophy of science and on tides. Peter came from a line of mathematicians. His father, Robert Wilson, immigrated to Australia from Glasgow in 1911, and became a mathematics teacher at Scotch College, a private school in Melbourne. There his name was changed to 'Bill' because 'Bob' was already taken." Peter's enjoyment of this story as characteristic of Australian academia (as any fan of Monty Python would understand) is indicative of his infectious sense of humor. In a similar vein, he claimed ancestry traced back to the eighteenth-century Scottish mathematician Alexander Wilson, Professor of Astronomy at the University of Glasgow. That Wilson is famous in the solar physics community for his discovery, known as the "Wilson Effect," of the photospheric depressions associated with sunspots. Peter himself could not resist writing a paper on this subject, and was delighted when the bait was taken by some less-informed colleagues who chided him for "naming an effect after himself." "Bill" Wilson married Naomi
Wilson disease in a Nigerian child: a case report
Directory of Open Access Journals (Sweden)
Esezobor Christopher
2012-07-01
Full Text Available Abstract Introduction Wilson disease is rarely reported among African children. This report describes the second case report of a Nigerian child with Wilson disease in three decades. Case presentation An eight-year-old African boy presented with generalized oedema and ascites and proteinuria. Over the next three weeks he developed conjugated hyperbilirubinaemia, severe coagulopathy and prominent extrapyramidal features consisting of rigidity, tremors at rest and in action, shuffling gait, slurred speech and emotional lability. Slit-lamp examination of his eyes revealed Kayser-Fleischer rings and sunflower cataracts. His serum caeruloplasmin level was 5mg/dL. Using the scoring system proposed by the 8th International Meeting of Wilson Disease and Menkes Disease, a diagnosis of Wilson disease was made. Conclusions Wilson disease does occur in African children, although the diagnosis is rarely made. A diagnosis of Wilson disease should be entertained in the evaluation of African children presenting with liver dysfunction and/or extrapyramidal neurological features.
Stability discussion of two integration formats for Wilson-θ Method%Wilson-θ法两种积分格式的稳定性探讨
Institute of Scientific and Technical Information of China (English)
方德平; 王全凤
2008-01-01
Wilson-θ法分为加速度未经过和经过动力平衡方程修正的Wilson-θ①法和Wilson-θ②法;推导了单自由庹体系的Wilson-θ①、②法的状态传递算子,由传递算子的谱半径来判断Wilson-θ①、②法的稳定性.计算结果表明:Wilson-θ①法的稳定性是无条件的,Wilson-θ②法的稳定性不是无条件的;并给出了Wilson-θ②法的稳定范围.
A genetic study of Wilson's disease in the United Kingdom.
Coffey, Alison J; Durkie, Miranda; Hague, Stephen; McLay, Kirsten; Emmerson, Jennifer; Lo, Christine; Klaffke, Stefanie; Joyce, Christopher J; Dhawan, Anil; Hadzic, Nedim; Mieli-Vergani, Giorgina; Kirk, Richard; Elizabeth Allen, K; Nicholl, David; Wong, Siew; Griffiths, William; Smithson, Sarah; Giffin, Nicola; Taha, Ali; Connolly, Sally; Gillett, Godfrey T; Tanner, Stuart; Bonham, Jim; Sharrack, Basil; Palotie, Aarno; Rattray, Magnus; Dalton, Ann; Bandmann, Oliver
2013-05-01
Previous studies have failed to identify mutations in the Wilson's disease gene ATP7B in a significant number of clinically diagnosed cases. This has led to concerns about genetic heterogeneity for this condition but also suggested the presence of unusual mutational mechanisms. We now present our findings in 181 patients from the United Kingdom with clinically and biochemically confirmed Wilson's disease. A total of 116 different ATP7B mutations were detected, 32 of which are novel. The overall mutation detection frequency was 98%. The likelihood of mutations in genes other than ATP7B causing a Wilson's disease phenotype is therefore very low. We report the first cases with Wilson's disease due to segmental uniparental isodisomy as well as three patients with three ATP7B mutations and three families with Wilson's disease in two consecutive generations. We determined the genetic prevalence of Wilson's disease in the United Kingdom by sequencing the entire coding region and adjacent splice sites of ATP7B in 1000 control subjects. The frequency of all single nucleotide variants with in silico evidence of pathogenicity (Class 1 variant) was 0.056 or 0.040 if only those single nucleotide variants that had previously been reported as mutations in patients with Wilson's disease were included in the analysis (Class 2 variant). The frequency of heterozygote, putative or definite disease-associated ATP7B mutations was therefore considerably higher than the previously reported occurrence of 1:90 (or 0.011) for heterozygote ATP7B mutation carriers in the general population (P Wilson's disease of 1:30 000 (P = 0.00093). Our study provides strong evidence for monogenic inheritance of Wilson's disease. It also has major implications for ATP7B analysis in clinical practice, namely the need to consider unusual genetic mechanisms such as uniparental disomy or the possible presence of three ATP7B mutations. The marked discrepancy between the genetic prevalence and the number of
Pregnancy in Wilson disease - management and outcome.
Pfeiffenberger, Jan; Beinhardt, Sandra; Gotthardt, Daniel N; Haag, Nicola; Freissmuth, Clarissa; Reuner, Ulrike; Gauss, Annika; Stremmel, Wolfgang; Schilsky, Michael L; Ferenci, Peter; Weiss, Karl Heinz
2017-08-31
Introduction Wilson disease (WD) is a rare inherited disorder of copper metabolism causing toxic hepatic and neural copper accumulation. Clinical symptoms vary widely, from asymptomatic disease to acute liver failure or chronic liver disease without or with neuropsychiatric symptoms. Continuation of specific medical treatment for WD is recommended during pregnancy, but reports of pregnancy outcomes in WD patients are sparse. Patients and methods In a retrospective, multicenter study, 282 pregnancies in 136 WD patients were reviewed. Age at disease onset, age at conception and WD-specific treatments were recorded. Maternal complications during pregnancy, rate of spontaneous abortions and birth defects were analyzed with respect to medical treatment during pregnancy. Results Worsening of liver function tests was evident during 16/282 (6%) pregnancies and occurred in undiagnosed patients as well as in those under medical treatment. Liver test abnormalities resolved in all cases after delivery. Aggravation of neurological symptoms during pregnancy was rare (1%) but tended to persist after delivery. The overall spontaneous abortion rate in the study cohort was 73/282 (26%). Patients with an established diagnosis of WD receiving medical treatment experienced significantly fewer spontaneous abortions than patients with undiagnosed WD (Odds ratio: 2.853 [95% CI: 1.634-4.982]). Birth defects occurred in 7/209 (3%) live births. Conclusion Pregnancy in WD patients on anti-copper therapy is safe. The spontaneous abortion rate in treated patients was lower than that in therapy-naive patients. Although the teratogenic potential of copper chelators is a concern, the rate of birth defects in our cohort was low. Treatment for WD should be maintained during pregnancy, and patients should be monitored closely for hepatic and neurologic symptoms. This article is protected by copyright. All rights reserved. © 2017 by the American Association for the Study of Liver Diseases.
The Wilson disease gene: Haplotypes and mutations
Energy Technology Data Exchange (ETDEWEB)
Thomas, G.R.; Roberts, E.A.; Cox, D.W. [Hospital for Sick Children, Toronto (Canada); Walshe, J.M. [Middlesex Hospital, London (United Kingdom)
1994-09-01
Wilson disease (WND) is an autosomal recessive defect of copper transport. The gene involved in WND, located on chromosome 13, has recently been shown to be a putative copper transporting P-type ATPase, designated ATP7B. The gene is highly similar to ATP7A, located on the X chromosome, which is defective in Menkes disease, another disorder of copper transport. We have available for study WND families from Canada (34 families), the United Kingdom (32 families), Japan (4 families), Iceland (3 families) and Hong Kong (2 families). We have utilized four highly polymorphic CA repeat markers (D13S296, D13S301, D13S314 and D13S316) surrounding the ATP7B locus to construct haplotypes in these families. Analysis indicates that there are many unique WND haplotypes not present on normal chromosomes and that there may be a large number of different WND mutations. We have screened the WND patients for mutations in the ATP7B gene. Fifty six patients, representing all of the identified haplotypes, have been screened using single strand conformational polymorphism (SSCP), followed by selective sequencing. To date, 19 mutations and 12 polymorphisms have been identified. All of the changes are nucleotide substitutions or small insertions/deletions and there is no evidence for larger deletions as seen in the similar gene on the X chromosome, ATP7A. Haplotypes of close markers and the ability to detect some of the mutations present in the gene allow for more reliable molecular diagnosis of presymptomatic sibs of WND patients. A reassessment of individuals previously diagnosed in the presymptomatic phase is now required, as we have have identified some heterozygotes who are biochemically indistinguishable from affected homozygotes. The identification of specific mutations will soon allow direct diagnosis of WND patients with a high level of certainty.
The BQP-hardness of approximating the Jones polynomial
Energy Technology Data Exchange (ETDEWEB)
Aharonov, Dorit; Arad, Itai, E-mail: itaia@cs.huji.ac.il [Department of Computer Science and Engineering, Hebrew University, Jerusalem (Israel)
2011-03-15
A celebrated important result due to Freedman et al (2002 Commun. Math. Phys. 227 605-22) states that providing additive approximations of the Jones polynomial at the kth root of unity, for constant k=5 and k{>=}7, is BQP-hard. Together with the algorithmic results of Aharonov et al (2005) and Freedman et al (2002 Commun. Math. Phys. 227 587-603), this gives perhaps the most natural BQP-complete problem known today and motivates further study of the topic. In this paper, we focus on the universality proof; we extend the result of Freedman et al (2002) to ks that grow polynomially with the number of strands and crossings in the link, thus extending the BQP-hardness of Jones polynomial approximations to all values to which the AJL algorithm applies (Aharonov et al 2005), proving that for all those values, the problems are BQP-complete. As a side benefit, we derive a fairly elementary proof of the Freedman et al density result, without referring to advanced results from Lie algebra representation theory, making this important result accessible to a wider audience in the computer science research community. We make use of two general lemmas we prove, the bridge lemma and the decoupling lemma, which provide tools for establishing the density of subgroups in SU(n). Those tools seem to be of independent interest in more general contexts of proving the quantum universality. Our result also implies a completely classical statement, that the multiplicative approximations of the Jones polynomial, at exactly the same values, are P-hard, via a recent result due to Kuperberg (2009 arXiv:0908.0512). Since the first publication of those results in their preliminary form (Aharonov and Arad 2006 arXiv:quant-ph/0605181), the methods we present here have been used in several other contexts (Aharonov and Arad 2007 arXiv:quant-ph/0702008; Peter and Stephen 2008 Quantum Inf. Comput. 8 681). The present paper is an improved and extended version of the results presented by Aharonov and
True unipolar ECG machine for Wilson Central Terminal measurements.
Gargiulo, Gaetano D
2015-01-01
Since its invention (more than 80 years ago), modern electrocardiography has employed a supposedly stable voltage reference (with little variation during the cardiac cycle) for half of the signals. This reference, known by the name of "Wilson Central Terminal" in honor of its inventor, is obtained by averaging the three active limb electrode voltages measured with respect to the return ground electrode. However, concerns have been raised by researchers about problems (biasing and misdiagnosis) associated with the ambiguous value and behavior of this reference voltage, which requires perfect and balanced contact of at least four electrodes to work properly. The Wilson Central Terminal has received scant research attention in the last few decades even though consideration of recent widespread medical practice (limb electrodes are repositioned closer to the torso for resting electrocardiography) has also sparkled concerns about the validity and diagnostic fitness of leads not referred to the Wilson Central Terminal. Using a true unipolar electrocardiography device capable of precisely measuring the Wilson Central Terminal, we show its unpredictable variability during the cardiac cycle and confirm that the integrity of cardinal leads is compromised as well as the Wilson Central Terminal when limb electrodes are placed close to the torso.
True Unipolar ECG Machine for Wilson Central Terminal Measurements
Directory of Open Access Journals (Sweden)
Gaetano D. Gargiulo
2015-01-01
Full Text Available Since its invention (more than 80 years ago, modern electrocardiography has employed a supposedly stable voltage reference (with little variation during the cardiac cycle for half of the signals. This reference, known by the name of “Wilson Central Terminal” in honor of its inventor, is obtained by averaging the three active limb electrode voltages measured with respect to the return ground electrode. However, concerns have been raised by researchers about problems (biasing and misdiagnosis associated with the ambiguous value and behavior of this reference voltage, which requires perfect and balanced contact of at least four electrodes to work properly. The Wilson Central Terminal has received scant research attention in the last few decades even though consideration of recent widespread medical practice (limb electrodes are repositioned closer to the torso for resting electrocardiography has also sparkled concerns about the validity and diagnostic fitness of leads not referred to the Wilson Central Terminal. Using a true unipolar electrocardiography device capable of precisely measuring the Wilson Central Terminal, we show its unpredictable variability during the cardiac cycle and confirm that the integrity of cardinal leads is compromised as well as the Wilson Central Terminal when limb electrodes are placed close to the torso.
Anesthetic Management of a Pediatric Patient With Wilsons Disease
Baykal, Mehmet; Karapolat, Sami
2010-01-01
Wilsons disease, characterized by cirrhosis, extrapyramidal symptoms and Kayser-Fleischer corneal rings, is a rare hereditary disease of human copper metabolism. Clinical findings in Wilsons disease are complex and neurological symptoms such as tremor, dysarthria, rigid dystonia, seizures, psychiatric disorders, acute liver failure, chronic hepatitis or cirrhosis may develop. A 4-year-old male patient was operated for traumatic depressed skull fracture and intracerebral hematoma. He was diagnosed with Wilsons disease at the age of 2.5 years and treated with zinc sulphate and D-penicillamine. General anesthesia was induced with propofol, fentanyl, atracurium, and maintained with isoflurane, and oxygen. No complications were encountered during the operation or in the postoperative period. We concluded that general anesthesia can successfully be given to Wilsons disease patients using an anesthetic agent, the metabolism of which is least affected by the liver disease, one that induces least hepatic toxicity. By close follow-up of patients clinically and biochemically, it is possible to reduce the complication rates to a minimum. Keywords Wilson's Disease; Craniocerebral trauma; Thoracic injuries; General anesthesia; Surgery PMID:21811529
Instanton Corrections of 1/6 BPS Wilson Loops in ABJM Theory
Okuyama, Kazumi
2016-01-01
We study instanton corrections to the vacuum expectation value (VEV) of 1/6 BPS Wilson loops in ABJM theory from the Fermi gas approach. We mainly consider Wilson loops in the fundamental representation and winding Wilson loops, but we also initiate the study of Wilson loops with two boundaries. We find that the membrane instanton corrections to the Wilson loop VEV are determined by the refined topological string in the Nekrasov-Shatashvili limit, and the pole cancellation mechanism between membrane instantons and worldsheet instantons works also in the Wilson loop VEVs as in the case of the partition functions.
Freezing point depression in model Lennard-Jones solutions
Koschke, Konstantin; Jörg Limbach, Hans; Kremer, Kurt; Donadio, Davide
2015-09-01
Crystallisation of liquid solutions is of uttermost importance in a wide variety of processes in materials, atmospheric and food science. Depending on the type and concentration of solutes the freezing point shifts, thus allowing control on the thermodynamics of complex fluids. Here we investigate the basic principles of solute-induced freezing point depression by computing the melting temperature of a Lennard-Jones fluid with low concentrations of solutes, by means of equilibrium molecular dynamics simulations. The effect of solvophilic and weakly solvophobic solutes at low concentrations is analysed, scanning systematically the size and the concentration. We identify the range of parameters that produce deviations from the linear dependence of the freezing point on the molal concentration of solutes, expected for ideal solutions. Our simulations allow us also to link the shifts in coexistence temperature to the microscopic structure of the solutions.
Nucleation for Lennard-Jones Fluid by Density Functional Theory
Institute of Scientific and Technical Information of China (English)
FU Dong
2005-01-01
@@ A non-mean field density functional theory is employed to investigate the vapour-liquid nucleation. The excess Helmholtz free energy functional is formulated in terms of a local density approximation for short ranged repulsion and a density-gradient expansion for long-ranged attractions. An analytical expression for the direct correlation function of a Lennard-Jones fluid is utilized to take into account the effect of long-ranged attractions on intermolecular correlations. With the predicted bulk properties and surface tension as input, the nucleation properties including density profile, work of formation and number of particles at the reduced temperatures T* = 0.694 and 0.741 are inuestigated. The obtained number of particles in the critical nucleus agrees well with the simulation data.
Dow Jones Fund Opens Journalism Programs to White Students after Lawsuit
Scmidt, Peter
2007-01-01
This paper discusses a Lawsuit filed against Dow Jones Newspaper Fund and the legal settlement between the defendant and the plaintiff. The fund, a nonprofit organization affiliated with Dow Jones & Company had been operating more than 20 programs for minority high-school students to pursue careers in newspaper journalism. The organization…
Obituary: Andrew Stephen Wilson, 1947-2008
Veilleux, Sylvain
2009-01-01
On 24 May 2008, Andrew Stephen Wilson passed away at the age of 61, in his home in Silver Spring, Maryland, from complications resulting from a painful spinal illness. Andrew was arguably one of the first truly multi-wavelength astronomers of his generation. His scientific work on active galactic nuclei [AGN] spanned the entire electromagnetic spectrum from the radio to the X-rays. Andrew was born in Doncaster, Yorkshire, England, on 26 March 1947. He was the younger of two brothers whose births were separated by the Second World War. His father, Norman, came from a relatively affluent family who were coal merchants. His mother, Mary, came from a less comfortable background, one of seven children, daughter of a skilled cabinet maker/French polisher, who went through a very hard time during the depression. As a teacher, she placed enormous value on hard work and education as a way of gaining advancement in life. When Andrew was four, the family moved to Skipton, a nice market town in the Yorkshire dales. Andrew went to a small village school until age eleven when he entered Ermysted's Grammar School. He was an enthusiastic soccer and cricket player. He never lost his enthusiasm for soccer and supported the local soccer team, Leeds United, for all his life. Andrew also followed the Yorkshire county cricket team. Andrew's interest in astronomy stemmed from the fact that at Ermysted's Grammar School someone donated a four-inch refracting telescope, so he and his friends used to go back in the evenings to investigate the rings of Saturn, the moons of Jupiter, and various nebulae. While an undergraduate at Cambridge, Andrew joined the astronomy club and ground an 8-inch mirror by hand as a part of a telescope that he set up in the backyard of his parents' house. Andrew spent hours observing with this telescope, and it was the wonder of the family. At Cambridge, Andrew obtained his bachelor's degree with first-class honors in 1969. During a short visit in London with his
Light-cone Wilson loop in classical lattice gauge theory
Laine, M
2013-01-01
The transverse broadening of an energetic jet passing through a non-Abelian plasma is believed to be described by the thermal expectation value of a light-cone Wilson loop. In this exploratory study, we measure the light-cone Wilson loop with classical lattice gauge theory simulations. We observe, as suggested by previous studies, that there are strong interactions already at short transverse distances, which may lead to more efficient jet quenching than in leading-order perturbation theory. We also verify that the asymptotics of the Wilson loop do not change qualitatively when crossing the light cone, which supports arguments in the literature that infrared contributions to jet quenching can be studied with dimensionally reduced simulations in the space-like domain. Finally we speculate on possibilities for full four-dimensional lattice studies of the same observable, perhaps by employing shifted boundary conditions in order to simulate ensembles boosted by an imaginary velocity.
Misdiagnosis of Wilson's disease in a patient with psychiatric symptoms
Directory of Open Access Journals (Sweden)
Doval Nimisha
2016-01-01
Full Text Available Therapeutic outcome of Wilson's disease significantly depends upon its early recognition. As Wilson's disease is a rare disorder with protean manifestations, its diagnosis and subsequent treatment are often delayed. We elaborate here the case of a young boy who had initially presented with psychiatrc symptoms suggestive of dissociative fugue followed by withdrawn behaviour and was treated by a psychiatrist with minimal response. This was associated with symptoms of tremors, hypersalivation, and slowness of movements. This case highlights the delay in diagnosing Wilson's disease when faced with the case of a young adult with psychiatric manifestations. It is extremely important for physicians, psychiatrists and health professionals at primary care level to recognize and diagnose this treatable disease at an early stage.
White matter changes in Wilson's disease: A radiological enigma
Directory of Open Access Journals (Sweden)
Soumava Mukherjee
2016-01-01
Full Text Available Wilson's disease is a metabolic disorder which presents with hepatitis or hepatic decompensation commonly. Neurologic manifestations are late and include movement disorders, personality changes, and seizures. Magnetic resonance imaging (MRI brain shows high signal changes in putamen, lentiform nucleus, thalamus, and brainstem. White matter lesions are rare. We report a child of Wilson's disease who presented to us with dystonia, rigidity, myoclonus and had symmetrical white matter changes in the fronto-parietooccipital region. Diffusion restriction in bilateral frontoparietal areas was also seen which is rare in chronic cases like ours. Atypical MRI characteristics should be considered in patients with clinical signs of neurological involvement in Wilson's disease as it is a devastating but treatable disease.
Misdiagnosis of Wilson's Disease in a Patient with Psychiatric Symptoms.
Nimisha, Doval; Dhruv, Batra; Vikas, Moun; Sneh, Jha K; Rakesh, Shukla
2016-01-01
Therapeutic outcome of Wilson's disease significantly depends upon its early recognition. As Wilson's disease is a rare disorder with protean manifestations, its diagnosis and subsequent treatment are often delayed. We elaborate here the case of a young boy who had initially presented with psychiatrc symptoms suggestive of dissociative fugue followed by withdrawn behaviour and was treated by a psychiatrist with minimal response. This was associated with symptoms of tremors, hypersalivation, and slowness of movements. This case highlights the delay in diagnosing Wilson's disease when faced with the case of a young adult with psychiatric manifestations. It is extremely important for physicians, psychiatrists and health professionals at primary care level to recognize and diagnose this treatable disease at an early stage.
Clinical considerations for an effective medical therapy in Wilson's disease.
Weiss, Karl Heinz; Stremmel, Wolfgang
2014-05-01
Wilson's disease is an autosomal recessively inherited copper overload disorder that leads to hepatic and/or neurologic symptoms. More than a century after the first description of Wilson's disease, the available medical treatment options have not been standardized. The efficacy of the commonly used drugs is satisfactory for hepatic disease, but disappointing in the neurologic patients, including the risk of neurologic deterioration after the initiation of chelation therapy. An approach to overcome this problem is the careful and systematic assessment of biochemical response patterns and the quantitative monitoring of symptoms using validated rating scales. Standardized dosage strategies that address changes in copper pools might improve adherence and reduce side effects. Such an approach may reduce long-term morbidity. In this paper, we discuss considerations for an effective medical treatment and requirements for future studies in Wilson's disease.
White matter changes in Wilson's disease: A radiological enigma.
Mukherjee, Soumava; Solanki, Bhavesh; Guha, Goutam; Saha, Shankar Prasad
2016-01-01
Wilson's disease is a metabolic disorder which presents with hepatitis or hepatic decompensation commonly. Neurologic manifestations are late and include movement disorders, personality changes, and seizures. Magnetic resonance imaging (MRI) brain shows high signal changes in putamen, lentiform nucleus, thalamus, and brainstem. White matter lesions are rare. We report a child of Wilson's disease who presented to us with dystonia, rigidity, myoclonus and had symmetrical white matter changes in the fronto-parietooccipital region. Diffusion restriction in bilateral frontoparietal areas was also seen which is rare in chronic cases like ours. Atypical MRI characteristics should be considered in patients with clinical signs of neurological involvement in Wilson's disease as it is a devastating but treatable disease.
Low serum alkaline phosphatase activity in Wilson's disease.
Shaver, W A; Bhatt, H; Combes, B
1986-01-01
Low values for serum alkaline phosphatase activity were observed early in the course of two patients with Wilson's disease presenting with the combination of severe liver disease and Coombs' negative acute hemolytic anemia. A review of other cases of Wilson's disease revealed that 11 of 12 patients presenting with hemolytic anemia had values for serum alkaline phosphatase less than their respective sex- and age-adjusted mean values; in eight, serum alkaline phosphatase activity was less than the lower value for the normal range of the test. Low values for serum alkaline phosphatase were much less common in Wilson's disease patients with more chronic forms of presentation. Copper added in high concentration to serum in vitro did not have an important effect on serum alkaline phosphatase activity. The mechanism responsible for the decrease in serum alkaline phosphatase activity in patients is uncertain.
Semiclassical correlation functions of Wilson loops and local vertex operators
Hernandez, Rafael
2012-01-01
We analyze correlation functions of Wilson loop observables and local vertex operators within the strong-coupling regime of the AdS/CFT correspondence. When the local operator corresponds to a light string state with finite conserved charges the correlation function can be evaluated in the semiclassical approximation of large string tension, where the contribution from the light vertex can be neglected. We consider the cases where the Wilson loops are described by two concentric surfaces and the local vertices are the superconformal chiral primary scalar or a singlet massive scalar operator.
Vector and Axial Currents in Wilson Chiral Perturbation Theory
Aoki, Sinya; Sharpe, Stephen R
2009-01-01
We reconsider the construction of the vector and axial-vector currents in Wilson Chiral Perturbation Theory (WChPT), the low-energy effective theory for lattice QCD with Wilson fermions. We discuss in detail the finite renormalization of the currents that has to be taken into account in order to properly match the currents. We explicitly show that imposing the chiral Ward identities on the currents does, in general, affect the axial-vector current at O(a). As an application of our results we compute the pion decay constant to one loop in the two flavor theory. Our result differs from previously published ones.
CT hypodensity on cerebral white matter in Wilson's disease
Directory of Open Access Journals (Sweden)
Laura B. Jardim
1991-06-01
Full Text Available Wilson's disease in an autosomal recessive disorder of copper metabolism where systemic manifestations are secondary to thei accumulation of copper in hepatic, nervous and other tissues. In CNS, the structural lesions most commonly found by CT scan are ventricular dilatation, cortical atrophy, basal ganglia hyperdensities, and brainstem and cerebellar atrophy. Degenerative changes of cerebral white matter seen on early anatomo-pathologic studies, but were almost never found on CT scan from recently described patients. We report a case of Wilson's disease with an unusually rapid deterioration where asymmetric low-densities in the subcortical white matter were disclosed by CT scan.
Face of the giant panda sign in Wilson disease
Directory of Open Access Journals (Sweden)
Sumit Chakraborty
2013-08-01
Full Text Available Wilson disease usually presents with neurologic or hepatic manifestations. Magnetic resonance imaging (MRI of the brain is very informative in diagnosiing of this disease, especially in patients with neurological features. High T2 signal intensity in the corpus striatum is the most commonly encountered MRI finding. The 'face of the giant panda' sign is seen on axial T2-weighted MRI, and results from abnormal signal intensities in the midbrain. Though uncommon, the sign is considered as the pathognomonic MRI sign of Wilson disease.
Morita duality and noncommutative Wilson loops in two dimensions
Cirafici, Michele; Griguolo, Luca; Seminara, Domenico; Szabo, Richard J.
2005-10-01
We describe a combinatorial approach to the analysis of the shape and orientation dependence of Wilson loop observables on two-dimensional noncommutative tori. Morita equivalence is used to map the computation of loop correlators onto the combinatorics of non-planar graphs. Several strong nonperturbative evidences of symmetry breaking under area-preserving diffeomorphisms are thereby presented. Analytic expressions for correlators of Wilson loops with infinite winding number are also derived and shown to agree with results from ordinary Yang-Mills theory.
Clinical presentation and mutations in Danish patients with Wilson disease
DEFF Research Database (Denmark)
Møller, Lisbeth Birk; Horn, Nina; Jeppesen, Tina Dysgaard
2011-01-01
This study describes the clinical presentation and diagnosis in all Danish patients (49, 41 unrelated) with Wilson disease (WND). On the basis of the number of diagnosed patients from 1990-2008, the prevalence was estimated to be 1:49¿500. Among routinely used diagnostic tests, none were consiste......This study describes the clinical presentation and diagnosis in all Danish patients (49, 41 unrelated) with Wilson disease (WND). On the basis of the number of diagnosed patients from 1990-2008, the prevalence was estimated to be 1:49¿500. Among routinely used diagnostic tests, none were...
Clinical presentation and mutations in Danish patients with Wilson disease
DEFF Research Database (Denmark)
Møller, Lisbeth Birk; Horn, Nina; Jeppesen, Tina Dysgaard
2011-01-01
This study describes the clinical presentation and diagnosis in all Danish patients (49, 41 unrelated) with Wilson disease (WND). On the basis of the number of diagnosed patients from 1990-2008, the prevalence was estimated to be 1:49 500. Among routinely used diagnostic tests, none were consiste......This study describes the clinical presentation and diagnosis in all Danish patients (49, 41 unrelated) with Wilson disease (WND). On the basis of the number of diagnosed patients from 1990-2008, the prevalence was estimated to be 1:49 500. Among routinely used diagnostic tests, none were...
Mowat-Wilson syndrome in a Moroccan consanguineous family
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Ratbi Ilham
2007-01-01
Full Text Available Mowat-Wilson syndrome is a mental retardation-multiple congenital anomaly syndrome characterized by a typical facies, developmental delay, epilepsy, and variable congenital malformations, including Hirschsprung disease, urogenital anomalies, congenital heart disease, and agenesis of the corpus callosum. This disorder is sporadic and is caused by heterozygous mutations or deletions of the ZFHX1B gene located in the 2q22 region. We report here the first Moroccan patient, born to consanguineous parents, with Mowat-Wilson syndrome, due to a de novo, unreported mutation of the ZFHX1B gene.
Wilson's disease, Kayser and Fleischer's sign and Walshe's treatment.
McIntyre, N
1991-01-01
Wilson's disease is named after Kinnier Wilson (1878-1937), a famous British neurologist. It is an inherited condition, due to an excess of copper in the liver and brain. The mechanism is unknown, but the gene has been mapped to chromosome 13. The worldwide prevalence is about 30 per million. Patients present with liver disease and/or neuropsychiatric manifestations. Early diagnosis is crucial because there is an effective treatment. This treatment, usually with penicillamine, must be continued for life and without interruption. Liver transplantation may be lifesaving in patients with fulminant hepatitis, or with severe liver disease which is unresponsive to treatment.
Exact results for Wilson loops in orbifold ABJM theory
Ouyang, Hao; Zhang, Jia-ju
2015-01-01
We investigate the exact results for circular 1/4 and 1/2 BPS Wilson loops in the d=3 N=4 super Chern-Simons-matter theory that could be obtained by orbifolding Aharony-Bergman-Jafferis-Maldacena (ABJM) theory. In literature there is the partition function of the N=4 orbifold ABJM theory, and we re-derive it in a slightly different method. We calculate the vacuum expectation values of the circular 1/4 and 1/2 BPS Wilson loops in both the saddle point approach and Fermi gas approach, and the results are in accord to the gravity ones.
Rapidity evolution of Wilson lines at the next-to-leading order
Energy Technology Data Exchange (ETDEWEB)
Balitsky, Ian [JLAB, Old Dominion U.; Chirilli, Giovanni [LBL
2013-12-01
At high energies particles move very fast so the proper degrees of freedom for the fast gluons moving along the straight lines are Wilson-line operators - infinite gauge factors ordered along the line. In the framework of operator expansion in Wilson lines the energy dependence of the amplitudes is determined by the rapidity evolution of Wilson lines. We present the next-to-leading order hierarchy of the evolution equations for Wilson-line operators.
Update on diagnosis of acute rheumatic fever: 2015 Jones criteria.
Eroğlu, Ayşe Güler
2016-03-01
In the final Jones criteria, different diagnostic criteria were established for the diagnosis of acute rheumatic fever for low risk and moderate-high risk populations. Turkey was found to be compatible with moderate-high risk populations as a result of regional screenings performed in terms of acute rheumatic fever and rheumatic heart disease. The changes in the diagnostic criteria for low-risk populations include subclinical carditis found on echocardiogram as a major criterion in addition to carditis found clinically and a body temperature of 38.5°C and above as a minor criterion. In moderate-high risk populations including Turkey, subclinical carditis found on echocardiogram in addition to clinical carditis is used as a major criterion as a new amendment. In addition, aseptic monoarthritis and polyarthralgia are used as major criteria in addition to migratory arthritis and monoarhtralgia is used as a minor criterion among joint findings. However, differentiation of subclinical carditis from physiological valve regurgitation found in healthy individuals and exclusion of other diseases involving joints when aseptic monoarthritis and polyarthralgia are used as major criteria are very important. In addition, a body temperature of 38°C and above and an erythrocyte sedimentation rate of 30 mm/h and above have been accepted as minor criteria. The diagnostic criteria for the first attack have not been changed; three minor findings have been accepted in presence of previous sterptococcal infection in addition to the old cirteria for recurrent attacks. In the final Jones criteria, it has been recommended that patients who do not fully meet the diagnostic criteria of acute rheumatic fever should be treated as acute rheumatic fever if another diagnosis is not considered and should be followed up with benzathine penicilin prophylaxis for 12 months. It has been decided that these patients be evaluated 12 months later and a decision for continuation or discontinuation of
Localization of the Wilson's disease protein in human liver
Schaefer, M; Roelofsen, H; Wolters, H; Hofmann, WJ; Muller, M; Kuipers, F; Stremmel, W; Vonk, RJ
1999-01-01
Background & Aims: Wilson's disease is an autosomal-recessive disorder of copper metabolism that results from the absence or dysfunction of a copper-transporting P-type adenosine triphosphatase that leads to impaired biliary copper excretion and disturbed holoceruloplasmin synthesis, To gain further
Large-N string tension from rectangular Wilson loops
Lohmayer, Robert
2012-01-01
In pure SU(N) gauge theory in four dimensions, we determine the string tension at large N from smeared rectangular Wilson loops on the lattice. We learn how well loops of sizes barely on the strong-coupling side of the large-N transition in their eigenvalue distribution can be described by effective string theory.
Finite Temperature Phase Diagramm of QCD with improved Wilson fermions
Karsch, Frithjof; Oevers, M; Schmidt, P
1998-01-01
We present first results of a study of two flavour QCD with Wilson fermions at finite temperature. We have used tree level Symanzik improvement in both the gauge and fermion part of the action. In a first step we explore the phase diagramm on an $8^3 \\times 4$ lattice, with particular emphasis on checking Aoki's conjecture with an improved action.
Alagille Syndrome and Wilson Disease in Siblings: A Diagnostic Conundrum
Directory of Open Access Journals (Sweden)
Meghan Amson
2012-01-01
Full Text Available The authors describe two siblings, each with a different, rare genetic condition that affects liver function. The index case, the 18-year-old asymptomatic brother of a young man recently diagnosed with Wilson disease, presented for Wilson disease screening and was also found to have abnormal liver function suggestive of cholestasis. However, ceruloplasmin level, 24 h urine copper concentration and liver synthetic function were normal. Further hepatic investigations and genetic mutation analysis were performed, ultimately leading to a diagnosis of Alagille syndrome. He was treated with ursodiol, which resulted in normalization of his liver function tests. Subsequently, he was found to be a carrier for a mutation in the Wilson disease gene, ATP7B. In the present report, the potential implications of being a heterozygote for Wilson disease in the context of Alagille syndrome are discussed. Also stressed is that care must be exercised by the clinician when diagnosing family members who may present with two different disorders closely mimicking one another.
Elevated copper impairs hepatic nuclear receptor function in Wilson's disease
Wilson's disease (WD) is an autosomal recessive disorder that results in accumulation of copper in the liver as a consequence of mutations in the gene encoding the copper-transporting P-type ATPase (ATP7B). WD is a chronic liver disorder, and individuals with the disease present with a variety of co...
Null Zig-Zag Wilson Loops in N=4 SYM
Xie, Zhifeng
2009-01-01
In planar ${\\cal N}=4$ supersymmetric Yang-Mills theory we have studied supersymmetric Wilson loops composed of a large number of light-like segments, i.e., null zig-zags. These contours oscillate around smooth underlying spacelike paths. At one-loop in perturbation theory we have compared the finite part of the expectation value of null zig-zags to the finite part of the expectation value of non-scalar-coupled Wilson loops whose contours are the underlying smooth spacelike paths. In arXiv:0710.1060 [hep-th] it was argued that these quantities are equal for the case of a rectangular Wilson loop. Here we present a modest extension of this result to zig-zags of circular shape and zig-zags following non-parallel, disconnected line segments and show analytically that the one-loop finite part is indeed that given by the smooth spacelike Wilson loop without coupling to scalars which the zig-zag contour approximates. We make some comments regarding the generalization to arbitrary shapes.
Null Zig-Zag Wilson Loops in {N}=4 Sym
Xie, Zhifeng
In planar {N}=4 supersymmetric Yang-Mills theory we have studied one kind of (locally) BPS Wilson loops composed of a large number of light-like segments, i.e. null zig-zags. These contours oscillate around smooth underlying spacelike paths. At one-loop in perturbation theory, we have compared the finite part of the expectation value of null zig-zags to the finite part of the expectation value of non-scalar-coupled Wilson loops whose contours are the underlying smooth spacelike paths. In arXiv:0710.1060 [hep-th] it was argued that these quantities are equal for the case of a rectangular Wilson loop. Here we present a modest extension of this result to zig-zags of circular shape and zig-zags following non-parallel, disconnected line segments and show analytically that the one-loop finite part is indeed that given by the smooth spacelike Wilson loop without coupling to scalars which the zig-zag contour approximates. We make some comments regarding the generalization to arbitrary shapes.
Municipal Broadband in Wilson, North Carolina: A Study
O'Boyle, Timothy
2012-01-01
Relatively little empirical attention has been paid to the political economy of publicly-retailed fiber-optic broadband internet service. To address this gap in the literature, this dissertation examines the history, dynamics and trends in the municipal broadband movement. In specific, Wilson, North Carolina's Greenlight service is examined in…
Holographic Wilson loops in anisotropic quark-gluon plasma.
Ageev, Dmitry
2016-10-01
The nonequilibrium properties of the anisotropic quark-gluon plasma are condidered from the holographic viewpoint. Lifshitz-like solution is considered as a holographic dual of anisotropic QGP. The black brane formation in such background is considered as a thermalization in dual theory. As a probe of thermalization we consider rectangular spatial Wilson loops with different orientation.
Holographic Wilson loops in anisotropic quark-gluon plasma.
Directory of Open Access Journals (Sweden)
Ageev Dmitry
2016-01-01
Full Text Available The nonequilibrium properties of the anisotropic quark-gluon plasma are condidered from the holographic viewpoint. Lifshitz-like solution is considered as a holographic dual of anisotropic QGP. The black brane formation in such background is considered as a thermalization in dual theory. As a probe of thermalization we consider rectangular spatial Wilson loops with different orientation.
The Non-Abelian Exponentiation theorem for multiple Wilson lines
Gardi, Einan; White, Chris D
2013-01-01
We study the structure of soft gluon corrections to multi-leg scattering amplitudes in a non-Abelian gauge theory by analysing the corresponding product of semi-infinite Wilson lines. We prove that diagrams exponentiate such that the colour factors in the exponent are fully connected. This completes the generalisation of the non-Abelian exponentiation theorem, previously proven in the case of a Wilson loop, to the case of multiple Wilson lines in arbitrary representations of the colour group. Our proof is based on the replica trick in conjunction with a new formalism where multiple emissions from a Wilson line are described by effective vertices, each having a connected colour factor. The exponent consists of connected graphs made out of these vertices. We show that this readily provides a general colour basis for webs. We further discuss the kinematic combinations that accompany each connected colour factor, and explicitly catalogue all three-loop examples, as necessary for a direct computation of the soft a...
Feynman graph solution to Wilson's exact renormalization group
Sonoda, H
2003-01-01
We introduce a new prescription for renormalizing Feynman diagrams. The prescription is similar to BPHZ, but it is mass independent, and works in the massless limit as the MS scheme with dimensional regularization. The prescription gives a diagrammatic solution to Wilson's exact renormalization group differential equation.
The non-Abelian exponentiation theorem for multiple Wilson lines
Gardi, Einan; Smillie, Jennifer M.; White, Chris D.
2013-06-01
We study the structure of soft gluon corrections to multi-leg scattering amplitudes in a non-Abelian gauge theory by analysing the corresponding product of semi-infinite Wilson lines. We prove that diagrams exponentiate such that the colour factors in the exponent are fully connected. This completes the generalisation of the non-Abelian exponentiation theorem, previously proven in the case of a Wilson loop, to the case of multiple Wilson lines in arbitrary representations of the colour group. Our proof is based on the replica trick in conjunction with a new formalism where multiple emissions from a Wilson line are described by effective vertices, each having a connected colour factor. The exponent consists of connected graphs made out of these vertices. We show that this readily provides a general colour basis for webs. We further discuss the kinematic combinations that accompany each connected colour factor, and explicitly catalogue all three-loop examples, as necessary for a direct computation of the soft anomalous dimension at this order.
An interview with Steve Wilson. Interview by Kathryn Senior.
Wilson, Steve
2010-05-01
Stephen Wilson is Professor of Developmental Genetics at University College, London, UK. He was recently awarded the Remedios Caro Almela Prize for Research in Developmental Neurobiology. We interviewed Steve to find out about how he started on the road to developmental biology research, how he got interested in the brain, his achievements and future challenges.
Proteomic investigation of whole saliva in Wilson's disease.
Cabras, Tiziana; Sanna, Monica; Manconi, Barbara; Fanni, Daniela; Demelia, Luigi; Sorbello, Orazio; Iavarone, Federica; Castagnola, Massimo; Faa, Gavino; Messana, Irene
2015-10-14
Wilson's disease is a rare inherited disorder of copper metabolism, manifesting hepatic, neurological and psychiatric symptoms. Early diagnosis is often unfeasible and a unique diagnostic test is currently inapplicable. We performed the qualitative/quantitative characterization of the salivary proteome/peptidome of 32 Wilson's disease patients by an integrated top-down/bottom-up approach. Patients exhibited significant higher levels of S100A9 and S100A8 proteoforms, and their oxidized forms with respect to controls. Oxidation occurred on methionine and tryptophan residues, and on the unique cysteine residue, in position 42 in S100A8, and 3 in S100A9, that generated glutathionylated, cysteinylated, sulfinic, sulfonic, and disulfide dimeric forms. Wilson's disease patient saliva showed high levels of two new fragments of the polymeric immunoglobulin receptor, and of α-defensins 2 and 4. Overall, the salivary proteome of Wilson's disease patients reflected oxidative stress and inflammatory conditions characteristic of the pathology, highlighting differences that could be useful clues of disease exacerbation.
Supersymmetric Wilson Loops and Super Non-Abelian Stokes Theorem
Karp, R L; Karp, Robert L.; Mansouri, Freydoon
2000-01-01
We generalize the standard product integral formalism to incorporateGrassmann valued matrices and show that the resulting supersymmetric productintegrals provide a natural framework for describing supersymmetric Wilsonlines and Wilson loops. We use this formalism to establish the supersymmetricversion of the non-Abelian Stokes Theorem.
Necessary and Sufficient Conditions for Expansions of Wilson Type
Institute of Scientific and Technical Information of China (English)
Kun Chuan WANG
2008-01-01
We consider expansions of the type arising from Wilson bases.We characterize such expansions for L2(R).As an application,we see that such an expansion must be orthonormal,in contrast to the case of wavelet expansions generated by translations and dilation.
The Wilson loop in the Gaussian Unitary Ensemble
Gurau, Razvan
2016-01-01
Using the supersymmetric formalism we compute exactly at finite $N$ the expectation of the Wilson loop in the Gaussian Unitary Ensemble and derive an exact formula for the spectral density at finite $N$. We obtain the same result by a second method relying on enumerative combinatorics and show that it leads to a novel proof of the Harer-Zagier series formula.
P wave dispersion is prolonged in patients with Wilson's disease
Institute of Scientific and Technical Information of China (English)
无
2008-01-01
AIM: To investigate the P wave dispersion as a noninvasive marker of intra-atrial conduction disturbances in patients with Wilson's disease. METHODS: We compared Wilson's disease patients (n=18) with age matched healthy subjects (n=15) as controls. The diagnosis was based on clinical symptoms, laboratory tests (ceruloplasmin, urinary and hepatic copper concentrations). P wave dispersion, a measurement of the heterogeneity of atrial depolarization, was measured as the difference between the duration of the longest and the shortest P-waves in 12 lead electrocardiography. RESULTS: All the patients were asymptomatic on cardiological examination and have sinusal rhythm in electrocardiography. Left ventricular and left atrial diameters, left ventricular ejection fraction and left ventricular mass index were similar in both groups. The Wilson's disease patients had a significantly higher P wave dispersion compared with the controls (44.7+5.8vs 25.7±2.5,P＜0.01＝. CONCLUSION: There was an increase in P wave dispersion in cardiologically asymptomatic Wilson's disease patients which probably represents an early stage of cardiac involvement.
Wilson lines and gauge invariant off-shell amplitudes
Kotko, Piotr
2014-01-01
We study matrix elements of Fourier-transformed straight infinite Wilson lines as a way to calculate gauge invariant tree-level amplitudes with off-shell gluons. The off-shell gluons are assigned "polarization vectors" which (in the Feynman gauge) are transverse to their off-shell momenta and define the direction of the corresponding Wilson line operators. The infinite Wilson lines are first regularized to prove the correctness of the method. We have implemented the method in a computer FORM program that can calculate gluonic matrix elements of Wilson line operators automatically. In addition we formulate the Feynman rules that are convenient in certain applications, e.g. proving the Ward identities. Using both the program and the Feynman rules we calculate a few examples, in particular the matrix elements corresponding to gauge invariant $g^{*}g^{*}g^{*}g$ and $g^{*}g^{*}g^{*}g^{*}g$ processes. An immediate application of the approach is in the high energy scattering, as in a special kinematic setup our resu...
Integrability and Wilson loops: the wavy line contour
Cagnazzo, A
2013-01-01
The Wilson loop with a wavy line contour is studied using integrable methods. The auxiliary problem is solved and the Lax operator is built to first order in perturbation theory, considering a small perturbation from the straight line. Finally the spectral curve of the solution is considered.
String theory duals of Wilson loops from Higgsing
Lietti, Marco; Mauri, Andrea; Penati, Silvia; Zhang, Jia-ju
2017-08-01
For three-dimensional ABJ(M) theories and N=4 Chern-Simons-matter quiver theories, we construct two sets of 1/2 BPS Wilson loop operators by applying the Higgsing procedure along independent directions of the moduli space, and choosing different massive modes. For theories whose dual M-theory description is known, we also determine the corresponding spectrum of 1/2 BPS M2-brane solutions. We identify the supercharges in M-theory and field theory, as well as the supercharges preserved by M2-/anti-M2-branes and 1/2 BPS Wilson loops. In particular, in N=4 orbifold ABJM theory we find pairs of different 1/2 BPS Wilson loops that preserve exactly the same set of supercharges. In field theory they arise by Higgsing with the choice of either particles or antiparticles, whereas in the dual description they correspond to a pair of M2-/anti-M2-branes localized at different positions in the compact space. This result enlightens the origin of classical Wilson loop degeneracy in these theories, already discussed in arXiv:1506.07614. A discussion on possible scenarios that emerge by comparison with localization results is included.
Wilson loops and topological phases in closed string theory
Cartas-Fuentevilla, R
2004-01-01
Using covariant phase space formulations for the natural topological invariants associated with the world-surface in closed string theory, we find that certain Wilson loops defined on the world-surface and that preserve topological invariance, correspond to wave functionals for the vacuum state with zero energy. The differences and similarities with the 2-dimensional QED proposed by Schwinger early are discussed.
Cardiac arrhythmia in Wilson's disease: An oversighted and overlooked entity!
Bajaj, Bhupender Kumar; Wadhwa, Ankur; Singh, Richa; Gupta, Saurabh
2016-01-01
Wilson's disease is a multisystem disorder which manifests with hepatic, neurological, musculoskeletal, hematological, renal, and cardiac symptoms. The hepatic and neurological manifestations often overshadow the other system involvement including cardiac symptoms and signs, which may prove fatal. We report a case of a young female who presented with progressive parkinsonian features and dystonia for around 4 months followed 2 months later by the complaint of episodes of light-headedness. She was diagnosed to have Wilson's disease based on the presence of Kayser–Fleischer ring and laboratory parameters of copper metabolism. Electrocardiography of the patient incidentally revealed 2nd degree Mobitz type-1 atrioventricular block explaining her episodes of light-headedness. She was started on penicillamine and trihexyphenidyl. The heart block improved spontaneously. Cardiac autonomic function tests including blood pressure response to standing and heart rate response to standing were observed to be normal. We review the literature on cardiac manifestations of Wilson's disease and emphasize that patients with Wilson's disease should be assessed for cardiac arrhythmia and cardiac dysfunction as these may have therapeutic and prognostic implications. PMID:27695244
Partition function for the eigenvalues of the Wilson line
Gocksch, A
1993-01-01
In a gauge theory at nonzero temperature the eigenvalues of the Wilson line form a set of gauge invariant observables. By constructing the corresponding partition function for the phases of these eigenvalues, we prove that the trivial vacuum, where the phases vanish, is a minimum of the free energy.
Imaginary Parts and Discontinuities of Wilson Line Correlators
Laenen, Eric; Larsen, Kasper J.; Rietkerk, Robbert
2015-01-01
We introduce a notion of position-space cuts of eikonal diagrams, the set of diagrams appearing in the perturbative expansion of the correlator of a set of straight semi-infinite Wilson lines. The cuts are applied directly to the position-space representation of any such diagramand compute its
Municipal Broadband in Wilson, North Carolina: A Study
O'Boyle, Timothy
2012-01-01
Relatively little empirical attention has been paid to the political economy of publicly-retailed fiber-optic broadband internet service. To address this gap in the literature, this dissertation examines the history, dynamics and trends in the municipal broadband movement. In specific, Wilson, North Carolina's Greenlight service is examined in…
Participation of Negroes in Woodrow Wilson Fellowship Programs.
Rosenhaupt, Hans
Woodrow Wilson Fellowships were awarded to 107 graduates from Negro colleges between 1958 and 1962 but to only 69 graduates during the following 5 years. The realization that this drop may have been caused by increased recruiting of Negro students by northern colleges and concern about the small number of black students at the graduate level led…
Woodrow Wilson National Fellowship Foundation. Report for 1971-1972.
Woodrow Wilson National Fellowship Foundation, Princeton, NJ.
This document presents the annual report for the Woodrow Wilson National Fellowship Foundation for 1971-72. Included in the report are a listing of the Board of Trustees; a listing of the officers and staff of the Foundation; descriptions of the First Year Fellowship Program, the Dissertation Fellowships, the Internship Programs, the Martin Luther…
Scattering amplitudes and Wilson loops in twistor space
Energy Technology Data Exchange (ETDEWEB)
Adamo, Tim; Mason, Lionel [Mathematical Institute, 24-29 St. Giles' , Oxford OX1 3LB (United Kingdom); Bullimore, Mathew [Rudolf Peierls Centre for Theoretical Physics, 1 Keble Road, Oxford OX1 3NP (United Kingdom); Skinner, David, E-mail: adamo@maths.ox.ac.uk [Perimeter Institute for Theoretical Physics, 31 Caroline Street North, Waterloo, Ontario N2 L 2Y5 (Canada)
2011-11-11
This paper reviews the recent progress in twistor approaches to Wilson loops, amplitudes and their duality for N=4 super-Yang-Mills. Wilson loops and amplitudes are derived from first principles using the twistor action for maximally supersymmetric Yang-Mills theory. We start by deriving the MHV rules for gauge theory amplitudes from the twistor action in an axial gauge in twistor space, and show that this gives rise to the original momentum space version given by Cachazo, Svrcek and Witten. We then go on to obtain from these the construction of the momentum twistor space loop integrand using (planar) MHV rules and show how it arises as the expectation value of a holomorphic Wilson loop in twistor space. We explain the connection between the holomorphic Wilson loop and certain light-cone limits of correlation functions. We give a brief review of other ideas in connection with amplitudes in twistor space: twistor-strings, recursion in twistor space, the Grassmannian residue formula for leading singularities and amplitudes as polytopes. This paper is an invited review for a special issue of Journal of Physics A: Mathematical and Theoretical devoted to 'Scattering amplitudes in gauge theories'. (review)
2013-12-06
... National Park Service Moose-Wilson Corridor Comprehensive Management Plan, Environmental Impact Statement... the Moose-Wilson Corridor, Grand Teton National Park, Wyoming. DATES: The National Park Service will...://parkplanning.nps.gov/MooseWilson , at the Grand Teton National Park Headquarters Building, 1 Teton Park...
Zeros of the Jones Polynomial for Torus Knots and 2-bridge Knots
Institute of Scientific and Technical Information of China (English)
HAN You-fa; ZHANG Rong-wei; WANG Lin-lin; MA Xiao-sha
2014-01-01
We study zeros of the Jones polynomial and their distributions for torus knots and 2-bridge knots. We prove that e(2m+1)πi/2 and e(2m+1)πi/4(m is a positive integer) can not be the zeros of Jones polynomial for torus knots Tp,q by the knowledge of the trigonometric function. We elicit the normal form of Jones polynomials of the 2-bridge knot C (−2, 2, · · · , (−1)r 2) by the recursive form and discuss the distribution of their zeros.
一种改进的Wilson-θ法及其算法稳定性%AN IMPROVED WILSON-θ METHOD AND ITS COMPUTATIONAL STABILITY
Institute of Scientific and Technical Information of China (English)
晏启祥; 刘浩吾; 何川
2003-01-01
在传统的Wilson-θ法的基础上,导出了改进的Wilson-θ法,比较了其与传统Wilson-θ法的异同点,分析了改进Wilson-θ法的稳定性.利用改进的Wilson-θ法建立了求解流固耦合方程的迭代算法,并对该算法进行检验,结果表明:改进的Wilson-θ法能方便地求解流固耦合振动方程,并能提高计算的效率.
Contact angle of sessile drops in Lennard-Jones systems.
Becker, Stefan; Urbassek, Herbert M; Horsch, Martin; Hasse, Hans
2014-11-18
Molecular dynamics simulations are used for studying the contact angle of nanoscale sessile drops on a planar solid wall in a system interacting via the truncated and shifted Lennard-Jones potential. The entire range between total wetting and dewetting is investigated by varying the solid-fluid dispersive interaction energy. The temperature is varied between the triple point and the critical temperature. A correlation is obtained for the contact angle in dependence of the temperature and the dispersive interaction energy. Size effects are studied by varying the number of fluid particles at otherwise constant conditions, using up to 150,000 particles. For particle numbers below 10,000, a decrease of the contact angle is found. This is attributed to a dependence of the solid-liquid surface tension on the droplet size. A convergence to a constant contact angle is observed for larger system sizes. The influence of the wall model is studied by varying the density of the wall. The effective solid-fluid dispersive interaction energy at a contact angle of θ = 90° is found to be independent of temperature and to decrease linearly with the solid density. A correlation is developed that describes the contact angle as a function of the dispersive interaction, the temperature, and the solid density. The density profile of the sessile drop and the surrounding vapor phase is described by a correlation combining a sigmoidal function and an oscillation term.
Magic Numbers for Classical Lennard-Jones Cluster Heat Capacities
Frantz, D D
1994-01-01
Heat capacity curves as functions of temperature for classical atomic clusters bound by pairwise Lennard-Jones potentials were calculated for aggregate sizes from 4 to 24 using Monte Carlo methods. J-walking (or jump-walking) was used to overcome convergence difficulties due to quasi-ergodicity in the solid-liquid transition region. The heat capacity curves were found to differ markedly and nonmonotonically as functions of cluster size. Curves for N = 4, 5 and 8 consisted of a smooth, featureless, monotonic increase throughout the transition region, while curves for N = 7 and 15-17 showed a distinct shoulder in this region; the remaining clusters had distinguishable transition heat capacity peaks. The size and location of these peaks exhibited "magic number" behavior, with the most pronounced peaks occurring for magic number sizes of N = 13, 19 and 23. A comparison of the heat capacities with other cluster properties in the solid-liquid transition region that have been reported in the literature indicates par...
Jones index, secret sharing and total quantum dimension
Fiedler, Leander; Naaijkens, Pieter; Osborne, Tobias J.
2017-02-01
We study the total quantum dimension in the thermodynamic limit of topologically ordered systems. In particular, using the anyons (or superselection sectors) of such models, we define a secret sharing scheme, storing information invisible to a malicious party, and argue that the total quantum dimension quantifies how well we can perform this task. We then argue that this can be made mathematically rigorous using the index theory of subfactors, originally due to Jones and later extended by Kosaki and Longo. This theory provides us with a ‘relative entropy’ of two von Neumann algebras and a quantum channel, and we argue how these can be used to quantify how much classical information two parties can hide form an adversary. We also review the total quantum dimension in finite systems, in particular how it relates to topological entanglement entropy. It is known that the latter also has an interpretation in terms of secret sharing schemes, although this is shown by completely different methods from ours. Our work provides a different and independent take on this, which at the same time is completely mathematically rigorous. This complementary point of view might be beneficial, for example, when studying the stability of the total quantum dimension when the system is perturbed.
Woodrow Wilson National Fellowship Foundation, Princeton, NJ.
Woodrow Wilson Fellows and Dissertation Fellows elected between 1945 and 1971 were surveyed to trace their educational careers, judge the effectiveness of the selection process, and determine what they are now doing with their education. Some elements covered by other national studies were included to make possible a comparison of the Woodrow…
Shape and distribution of Jones and Faddy's skew t random variable
Directory of Open Access Journals (Sweden)
Saipornchai, N.
2005-09-01
Full Text Available The purpose of this research is to find another way to generate Jones and Faddy's skew t random variable and to construct quantile table, coefficient of skewness, coefficient of kurtosis and coefficient of variation tables of Jones and Faddy's skew t distribution. Graphs of its probability density function and graphs of its distribution function are also presented. The results of this study show that Jones and Faddy's skew t random variable can be generated from a beta random variable on (-1,1. The coefficients of skewness and kurtosis of the distribution depend on parameters a and b. The coefficient of variation of Jones and Faddy's skew t distribution can be calculated.
The Grande Dame of Afro-American Art: Lois Mailou Jones.
LaDuke, Betty
1987-01-01
Chronicles the personal and professional life of Lois Mailou Jones, a Black woman painter who blends Western and non-Western aesthetic traditions in her art. The influences of Haitian and African native traditions on her work are discussed. (BJV)
Analysis of the Field of Public Management: A Response to Kelman, Thompson, Jones, and Schedler
Candreva, Philip J.
2004-01-01
This essay examines the field of public management as explicated in the dialogue between Kelman, Thompson, Jones and Schedler (2003) and others, from the perspective of the philosophy of science. While there may be wide consensus that a substantial body of information about public management exists, Kelman, Thompson, Jones and Schedler are consistent in their view that empirical generalizations and underlying principles do not exist. This assertion notwithstanding, this essay d...
Viola-Jones based hybrid framework for real-time object detection in multispectral images
Kuznetsova, E.; Shvets, E.; Nikolaev, D.
2015-12-01
This paper describes a method for real-time object detection based on a hybrid of a Viola-Jones cascade with a convolutional neural network. This scheme allows flexible trade-offs between detection quality and computational performance. We also propose a generalization of this method to multispectral images that effectively and efficiently utilizes information from each spectral channel. The new scheme is experimentally compared to traditional Viola-Jones, showing improved detection quality with adjustable performance.
Rogers-Ramanujan type identities and the head and tail of the colored Jones polynomial
Armond, Cody
2011-01-01
We study the head and tail of the colored Jones polynomial while focusing mainly on alternating links. Various ways to compute the colored Jones polynomial for a given link give rise to combinatorial identities for those power series. We further show that the head and tail functions only depend on the reduced checkerboard graphs of the knot diagram. Moreover the class of head and tail functions of prime alternating links forms a monoid.
Jones calculus modeling and analysis of the thermal distortion in a Ti:sapphire laser amplifier.
Cho, Seryeyohan; Jeong, Jihoon; Yu, Tae Jun
2016-06-27
The mathematical modeling of an anisotropic Ti:sapphire crystal with a significant thermal load is performed. The model is expressed by the differential Jones matrix. A thermally induced distortion in the chirped-pulse amplification process is shown by the solution of the differential Jones matrix. Using this model, the thermally distorted spatio-temporal laser beam shape is calculated for a high-power and high-repetition-rate Ti:sapphire amplifier.
Scaling of the dynamics of flexible Lennard-Jones chains.
Veldhorst, Arno A; Dyre, Jeppe C; Schrøder, Thomas B
2014-08-07
The isomorph theory provides an explanation for the so-called power law density scaling which has been observed in many molecular and polymeric glass formers, both experimentally and in simulations. Power law density scaling (relaxation times and transport coefficients being functions of ρ(γ(S)), where ρ is density, T is temperature, and γ(S) is a material specific scaling exponent) is an approximation to a more general scaling predicted by the isomorph theory. Furthermore, the isomorph theory provides an explanation for Rosenfeld scaling (relaxation times and transport coefficients being functions of excess entropy) which has been observed in simulations of both molecular and polymeric systems. Doing molecular dynamics simulations of flexible Lennard-Jones chains (LJC) with rigid bonds, we here provide the first detailed test of the isomorph theory applied to flexible chain molecules. We confirm the existence of isomorphs, which are curves in the phase diagram along which the dynamics is invariant in the appropriate reduced units. This holds not only for the relaxation times but also for the full time dependence of the dynamics, including chain specific dynamics such as the end-to-end vector autocorrelation function and the relaxation of the Rouse modes. As predicted by the isomorph theory, jumps between different state points on the same isomorph happen instantaneously without any slow relaxation. Since the LJC is a simple coarse-grained model for alkanes and polymers, our results provide a possible explanation for why power-law density scaling is observed experimentally in alkanes and many polymeric systems. The theory provides an independent method of determining the scaling exponent, which is usually treated as an empirical scaling parameter.
Hexagon Wilson loop = six-gluon MHV amplitude
Drummond, J M; Korchemsky, G P; Sokatchev, E
2008-01-01
We compare the two-loop corrections to the finite part of the light-like hexagon Wilson loop with the recent numerical results for the finite part of the MHV six-gluon amplitude in N=4 SYM theory by Bern, Dixon, Kosower, Roiban, Spradlin, Vergu and Volovich (arXiv:0803.1465 [hep-th]) and demonstrate that they coincide within the error bars and, at the same time, they differ from the BDS ansatz by a non-trivial function of (dual) conformal kinematical invariants. This provides strong evidence that the Wilson loop/scattering amplitude duality holds in planar N=4 SYM theory to all loops for an arbitrary number of external particles.
QCD at imaginary chemical potential with Wilson fermions
Alexandru, Andrei
2013-01-01
We investigate the phase diagram in the temperature, imaginary chemical potential plane for QCD with three degenerate quark flavors using Wilson type fermions. While more expensive than the staggered fermions used in past studies in this area, Wilson fermions can be used safely to simulate systems with three quark flavors. In this talk, we focus on the (pseudo)critical line that extends from $\\mu=0$ in the imaginary chemical potential plane, trace it to the Roberge-Weiss line, and determine its location relative to the Roberge-Weiss transition point. In order to smoothly follow the (pseudo)critical line in this plane we perform a multi-histogram reweighting in both temperature and chemical potential. To perform reweighting in the chemical potential we use the compression formula to compute the determinants exactly. Our results are compatible with the standard scenario.
Schroedinger functional formalism with Ginsparg-Wilson fermion
Taniguchi, Y
2005-01-01
The Schroedinger functional formalism is given as a field theory in a finite volume with a Dirichlet boundary condition in temporal direction. When one tries to construct this formalism with the Ginsparg-Wilson fermion including the overlap Dirac operator and the domain-wall fermion one easily runs into difficulties. The reason is that if the Dirichlet boundary condition is simply imposed on the Wilson Dirac operator $DW$ inside of the overlap Dirac operator an exponentially small eigenvalue appears in $DW$, which affects the locality properties of the operator. In this paper we propose a new procedure to impose the Schroedinger functional Dirichlet boundary condition on the overlap Dirac operator using an orbifolding projection.
O(a^2) cutoff effects in Wilson fermion simulations
Frezzotti, R
2007-01-01
We show that the size of the O(a^2) flavour violating cutoff artifacts that have been found to affect the value of the neutral pion mass in simulations with maximally twisted Wilson fermions is controlled by a continuum QCD quantity that is fairly large and is determined by the dynamical mechanism of spontaneous chiral symmetry breaking. One can argue that the neutral pion mass is the only physical quantity blurred by such cutoff effects. O(a^2) corrections of this kind are also present in standard Wilson fermion simulations, but they can either affect the determination of the pion mass or be shifted from the latter to other observables, depending on the way the critical mass is evaluated.
Mixed symmetry Wilson-loop interactions in the worldline formalism
Edwards, James P
2016-01-01
Using the worldline formalism of the Dirac field with a non-Abelian gauge symmetry we show how to describe the matter field transforming in an arbitrary representation of the gauge group. Colour degrees of freedom are carried on the worldline by auxiliary fields, responsible for providing path ordering and the Wilson-loop coupling. The Hilbert space of these fields is reducible but we make use of recent work in order to project onto a single, arbitrary, irreducible representation. By functionally quantising the resulting theory we show that this procedure correctly generates the Wilson-loop interaction between the gauge field and the matter field taken to transform in a chosen representation. This work has direct application to physical observables such as scattering amplitudes in the presence of such a matter multiplet and lifts the restriction on the type of matter that has previously featured in worldline calculations.
Improved quasi parton distribution through Wilson line renormalization
Chen, Jiunn-Wei; Zhang, Jian-Hui
2016-01-01
Recent developments showed that hadron light-cone parton distributions could be directly extracted from spacelike correlators, known as quasi parton distributions, in the large hadron momentum limit. Unlike the normal light-cone parton distribution, a quasi parton distribution contains ultraviolet (UV) power divergence associated with the Wilson line self energy. We show that to all orders in the coupling expansion, the power divergence can be removed by a "mass" counterterm in the auxiliary $z$-field formalism, in the same way as the renormalization of power divergence for an open Wilson line. After adding this counterterm, the quasi quark distribution is improved such that it contains at most logarithmic divergences. Based on a simple version of discretized gauge action, we present the one-loop matching kernel between the improved non-singlet quasi quark distribution with a lattice regulator and the corresponding quark distribution in dimensional regularization.
Scattering Amplitudes/Wilson Loop Duality In ABJM Theory
Bianchi, Marco S; Mauri, Andrea; Penati, Silvia; Santambrogio, Alberto
2011-01-01
For N=6 superconformal Chern-Simons-matter theories in three dimensions, by a direct superspace Feynman diagram approach, we compute the two-loop four-point scatteringa amplitude with external chiral matter fields. We find that the result is in perfect agreement with the two-loop result for a light-like four-polygon Wilson loop. This is a nontrivial evidence of the scattering amplitudes/Wilson loop duality in three dimensions. Moreover, both the IR divergent and the finite parts of our two-loop result agree with a BDS-like ansatz for all-loop amplitudes where the scaling function is given in terms of the N=4 SYM one, according to the conjectured Bethe equations for ABJM. Consequently, we are able to make a prediction for the four-loop correction to the amplitude. We also discuss the dual conformal invariance of the two-loop result.
Chiral solution to the Ginsparg-Wilson equation
Grabowska, Dorota M.; Kaplan, David B.
2016-12-01
We present a chiral solution of the Ginsparg-Wilson equation. This work is motivated by our recent proposal for nonperturbatively regulating chiral gauge theories, where five-dimensional domain wall fermions couple to a four-dimensional gauge field that is extended into the extra dimension as the solution to a gradient flow equation. Mirror fermions at the far surface decouple from the gauge field as if they have form factors that become infinitely soft as the distance between the two surfaces is increased. In the limit of an infinite extra dimension we derive an effective four-dimensional chiral overlap operator which is shown to obey the Ginsparg-Wilson equation, and which correctly reproduces a number of properties expected of chiral gauge theories in the continuum.
Anisotropic Superconvergence Analysis for the Wilson Nonconforming Element
Institute of Scientific and Technical Information of China (English)
Shaochun Chen; Huixia Sun; Shipeng Mao
2006-01-01
The regular condition (there exists a constant c independent of the element K and the mesh such that hK/ρK ≤ c, where hK and ρK are diameters of K and the biggest ball contained in K, respectively) or the quasi-uniform condition is a basic assumption in the analysis of classical finite elements. In this paper, the supercloseness for consistency error and the superconvergence estimate at the central point of the element for the Wilson nonconforming element in solving second-order elliptic boundary value problem are given without the above assumption on the meshes. Furthermore the global superconvergence for the Wilson nonconforming element is obtained under the anisotropic meshes. Lastly, a numerical test is carried out which confirms our theoretical analysis.
Spectral Properties of the Wilson Dirac Operator and RMT
Kieburg, Mario; Zafeiropoulos, Savvas
2013-01-01
Random Matrix Theory has been successfully applied to lattice Quantum Chromodynamics. In particular, a great deal of progress has been made on the understanding, numerically as well as analytically, of the spectral properties of the Wilson Dirac operator. In this paper, we study the infra-red spectrum of the Wilson Dirac operator via Random Matrix Theory including the three leading order $a^2$ correction terms that appear in the corresponding chiral Lagrangian. A derivation of the joint probability density of the eigenvalues is presented. This result is used to calculate the density of the complex eigenvalues, the density of the real eigenvalues and the distribution of the chiralities over the real eigenvalues. A detailed discussion of these quantities shows how each low energy constant affects the spectrum. Especially we consider the limit of small and large (which is almost the mean field limit) lattice spacing. Comparisons with Monte Carlo simulations of the Random Matrix Theory show a perfect agreement wi...
BPS Wilson Loops on S^2 at Higher Loops
Young, Donovan
2008-01-01
We consider supersymmetric Wilson loops of the variety constructed by Drukker, Giombi, Ricci, and Trancanelli, whose spatial contours lie on a two-sphere. Working to second order in the 't Hooft coupling in planar N=4 Supersymmetric Yang-Mills Theory (SYM), we compute the vacuum expectation value of a wavy-latitude and of a loop composed of two longitudes. We evaluate the resulting integrals numerically and find that the results are consistent with the zero-instanton sector calculation of Wilson loops in 2-d Yang-Mills on S^2 performed by Bassetto and Griguolo. We also consider the connected correlator of two distinct latitudes to third order in the 't Hooft coupling in planar N=4 SYM. We compare the result in the limit where the latitudes become coincident to a perturbative calculation in 2-d Yang-Mills on S^2 using a light-cone Wu-Mandelstam-Leibbrandt prescription. The two calculations produce differing results.
Emergent geometry from field theory: Wilson's renormalization group revisited
Kim, Ki-Seok; Park, Chanyong
2016-06-01
We find a geometrical description from a field theoretical setup based on Wilson's renormalization group in real space. We show that renormalization group equations of coupling parameters encode the metric structure of an emergent curved space, regarded to be an Einstein equation for the emergent gravity. Self-consistent equations of local order-parameter fields with an emergent metric turn out to describe low-energy dynamics of a strongly coupled field theory, analogous to the Maxwell equation of the Einstein-Maxwell theory in the AdSd +2 /CFTd +1 duality conjecture. We claim that the AdS3 /CFT2 duality may be interpreted as Landau-Ginzburg theory combined with Wilson's renormalization group, which introduces vertex corrections into the Landau-Ginzburg theory in the large-Ns limit, where Ns is the number of fermion flavors.
Improved quasi parton distribution through Wilson line renormalization
Directory of Open Access Journals (Sweden)
Jiunn-Wei Chen
2017-02-01
Full Text Available Recent developments showed that hadron light-cone parton distributions could be directly extracted from spacelike correlators, known as quasi parton distributions, in the large hadron momentum limit. Unlike the normal light-cone parton distribution, a quasi parton distribution contains ultraviolet (UV power divergence associated with the Wilson line self energy. We show that to all orders in the coupling expansion, the power divergence can be removed by a “mass” counterterm in the auxiliary z-field formalism, in the same way as the renormalization of power divergence for an open Wilson line. After adding this counterterm, the quasi quark distribution is improved such that it contains at most logarithmic divergences. Based on a simple version of discretized gauge action, we present the one-loop matching kernel between the improved non-singlet quasi quark distribution with a lattice regulator and the corresponding quark distribution in dimensional regularization.
A Chiral Solution to the Ginsparg-Wilson Equation
Grabowska, Dorota M
2016-01-01
We present a chiral solution of the Ginsparg-Wilson equation. This work is motivated by our recent proposal for nonperturbatively regulating chiral gauge theories, where five-dimensional domain wall fermions couple to a four-dimensional gauge field that is extended into the extra dimension as the solution to a gradient flow equation. Mirror fermions at the far surface decouple from the gauge field as if they have form factors that become infinitely soft as the distance between the two surfaces is increased. In the limit of an infinite extra dimension we derive an effective four-dimensional chiral overlap operator which is shown to obey the Ginsparg-Wilson equation, and which correctly reproduces a number of properties expected of chiral gauge theories in the continuum.
Six-dimensional Landau-Ginzburg-Wilson theory
Gracey, J. A.; Simms, R. M.
2017-01-01
We renormalize the six-dimensional cubic theory with an O (N )×O (m ) symmetry at three loops in the modified minimal subtraction (MS ¯ ) scheme. The theory lies in the same universality class as the four-dimensional Landau-Ginzburg-Wilson model. As a check we show that the critical exponents derived from the three-loop renormalization group functions at the Wilson-Fisher fixed point are in agreement with the large N d -dimensional critical exponents of the underlying universal theory. Having established this connection we analyze the fixed point structure of the perturbative renormalization group functions to estimate the location of the conformal window of the O (N )×O (2 ) model.
An Operator Product Expansion for Polygonal null Wilson Loops
Alday, Luis F; Maldacena, Juan; Sever, Amit; Vieira, Pedro
2010-01-01
We consider polygonal Wilson loops with null edges in conformal gauge theories. We derive an OPE-like expansion when several successive lines of the polygon are becoming aligned. The limit corresponds to a collinear, or multicollinear, limit and we explain the systematics of all the subleading corrections, going beyond the leading terms that were previously considered. These subleading corrections are governed by excitations of high spin operators, or excitations of a flux tube that goes between two Wilson lines. The discussion is valid for any conformal gauge theory, for any coupling and in any dimension. For N=4 super Yang Mills we check this expansion at strong coupling and at two loops at weak coupling . We also make predictions for the remainder function at higher loops. In the process, we also derived a new version for the TBA integral equations that determine the strong coupling answer and present the area as the associated Yang-Yang functional.
Entanglement entropy of Wilson loops: Holography and matrix models
Gentle, Simon A
2014-01-01
A half-BPS circular Wilson loop in $\\mathcal{N}=4$ $SU(N)$ supersymmetric Yang-Mills theory in an arbitrary representation is described by a Gaussian matrix model with a particular insertion. The additional entanglement entropy of a spherical region in the presence of such a loop was recently computed by Lewkowycz and Maldacena using exact matrix model results. In this note we utilize the supergravity solutions that are dual to such Wilson loops in a representation with order $N^2$ boxes to calculate this entropy holographically. Employing the matrix model results of Gomis, Matsuura, Okuda and Trancanelli we express this holographic entanglement entropy in a form that can be compared with the calculation of Lewkowycz and Maldacena. We find complete agreement between the matrix model and holographic calculations.
Integrability of Smooth Wilson Loops in N=4 Superspace
Beisert, Niklas; Plefka, Jan; Vergu, Cristian
2015-01-01
We perform a detailed study of the Yangian symmetry of smooth supersymmetric Maldacena-Wilson loops in planar N=4 super Yang-Mills theory. This hidden symmetry extends the global superconformal symmetry present for these observables. A gauge-covariant action of the Yangian generators on the Wilson line is established that generalizes previous constructions built upon path variations. Employing these generators the Yangian symmetry is proven for general paths in non-chiral N=4 superspace at the first perturbative order. The bi-local piece of the level-one generators requires the use of a regulator due to divergences in the coincidence limit. We perform regularization by point splitting in detail, thereby constructing additional local and boundary contributions as regularization for all level-one Yangian generators. Moreover, the Yangian algebra at level one is checked and compatibility with local kappa-symmetry is established. Finally, the consistency of the Yangian symmetry is shown to depend on two propertie...
Entanglement entropy of Wilson loops: Holography and matrix models
Gentle, Simon A.; Gutperle, Michael
2014-09-01
A half-Bogomol'nyi-Prasad-Sommerfeld circular Wilson loop in N=4 SU(N) supersymmetric Yang-Mills theory in an arbitrary representation is described by a Gaussian matrix model with a particular insertion. The additional entanglement entropy of a spherical region in the presence of such a loop was recently computed by Lewkowycz and Maldacena using exact matrix model results. In this paper we utilize the supergravity solutions that are dual to such Wilson loops in a representation with order N2 boxes to calculate this entropy holographically. Employing the matrix model results of Gomis, Matsuura, Okuda and Trancanelli we express this holographic entanglement entropy in a form that can be compared with the calculation of Lewkowycz and Maldacena. We find complete agreement between the matrix model and holographic calculations.
Raising and Lowering Operators for Askey-Wilson Polynomials
Directory of Open Access Journals (Sweden)
Siddhartha Sahi
2007-01-01
Full Text Available In this paper we describe two pairs of raising/lowering operators for Askey-Wilson polynomials, which result from constructions involving very different techniques. The first technique is quite elementary, and depends only on the ''classical'' properties of these polynomials, viz. the q-difference equation and the three term recurrence. The second technique is less elementary, and involves the one-variable version of the double affine Hecke algebra.
Orthotropic liver transplantation for intractable neurological manifestations of Wilson's disease.
Sutariya, Vaibhav K; Tank, Anad H; Modi, Pranjal R
2015-01-01
Wilson's disease (WD) is an inherited autosomal recessive disorder characterized by copper accumulation and toxicity, affecting mainly the liver and brain. Orthotopic liver transplantation (OLT) is the definitive therapy for patients with WD. Acute fulminant hepatic failure and decompensated cirrhosis are well-established indications for OLT. Patients with severe neurologic impairment can also be benefited by OLT. Here, we present a patient who underwent OLT for isolated neurological WD.
Wilson's disease: assessment of D-penicillamine treatment.
Van Caillie-Bertrand, M; Degenhart, H J; Luijendijk, I; Bouquet, J.; Sinaasappel, M.
1985-01-01
Serum copper and zinc concentrations and 24 hour urinary copper and zinc excretion were determined serially from the beginning of treatment with D-penicillamine in four children with Wilson's disease. The data show a progressive decrease in both serum copper and zinc concentrations in all. Urinary copper excretion gradually levelled off to approximately 50% of initial values, but zinc excretion increased. Urinary zinc:copper ratios therefore increased with the duration of treatment. Copper el...
Universal properties of large N phase transitions in Wilson loops
Narayanan, R
2007-01-01
Numerical studies support the conjecture that in continuum planar QCD the eigenvalue density of a Wilson loop operator undergoes a transition as the loop is dilated while keeping the loop shape fixed. A second part of the conjecture is that the transition obeys large N universality and that this universality class is the same in 2, 3 and 4 Euclidean space-time dimensions. The focus of the talk will be on clarifying precisely what the conjecture is claiming.
Wilson's disease: an analysis of 28 Brazilian children
Kleine, Rodolpho Truffa; Mendes, Renata; Pugliese, Renata; Miura, Irene; Danesi, Vera; Porta, Gilda
2012-01-01
OBJECTIVES: Clinical-laboratory and evolutionary analysis of twenty-eight patients with Wilson's disease. METHODS: Twenty-eight children (twelve females and sixteen males) with Wilson's disease were evaluated retrospectively between 1987 and 2009, with a follow-up of 72 months (1 – 240 months). The clinical, laboratory, and histologic features at diagnosis were recorded at the end of the study. RESULTS: The median age at diagnosis was 11 years (2 – 18 years). Twelve patients were asymptomatic, seven had hepatitis symptoms, five had raised aminotransferase levels, three had hepatomegaly associated with neurological disorders, one had fulminant hepatitis with hemolytic anemia, and six patients presented with a Kayser-Fleischer ring. A histological analysis revealed that six children had chronic hepatitis, seven had cirrhosis, two had steatosis, one had portal fibrosis, and one had massive necrosis. The treatment consisted of D-penicillamine associated with pyridoxine for 26 patients. Adverse effects were observed in the other two patients: one presented with uncontrollable vomiting and the other demonstrated elastosis perforans serpiginosa. At the end of the study, all 26 treated patients were asymptomatic. Twenty-four of the patients were treated with D-penicillamine and pyridoxine, and two were treated with trientine and zinc sulfate. A liver transplant was performed in one patient with fulminant hepatitis, but the final patient died 48 hours after admission to the intensive care unit. CONCLUSIONS: Family screenings associated with early treatment are important in preventing Wilson's disease symptoms and potentially fatal disease progression. The study suggests that Wilson's disease must be ruled out in children older than two years presenting with abnormal levels of hepatic enzymes because of the heterogeneity of symptoms and the encouraging treatment results obtained so far. PMID:22473403
Dynamics and the Wilson Cycle: An EarthScope vision
Ebinger, Cynthia; Humphreys, Eugene; Williams, Michael; van der Lee, Suzan; Levin, Vadim; Webb, Laura; Becker, Thorsten
2017-04-01
Wilson's model has two major components, each with distinctive observables. Initial subduction of ocean lithosphere collides continents across a closing ocean basin, creating a mountain range; rifting then initiates within the collisional orogeny and progresses to create oceanic spreading and creation of a new ocean basin. Subduction eventually initiates near the old, cold, and heavily sedimented continental margin, leading to subduction, and repeating the cycle. This model is largely kinematic in nature, and predictive in application. We re-evaluate the Wilson Cycle in light of process-oriented perspectives afforded by the surface to mantle Earthscope results. Repeating episodes of mountain building by means of continental collisions remains clear, but new observations augment or diverge from Wilson's concepts. A 'new' component stems from observations from both the East and West coasts: translational fault systems played critical roles in continental accretion, collision, and rifting. Earthscope data sets also have enabled imaging of the structure of western U.S. lithosphere with unprecedented detail. From new and existing data sets, we conclude that collision occurs in 'ribbons' in large part linked to the shapes of the landmasses colliding landmasses, and deformation includes a major component of transform tectonics. Post-orogenic gravitational collapse may occur far inboard of the site of collision. A third 'new' feature is that plate coupling with the mantle leads to deformation outside the classic Wilson Cycle. For example, the passive margin of eastern N. America shows tectonic activity, uplift, and magmatism long after the onset of seafloor spreading, demonstrating the dynamic nature of lithosphere-asthenosphere coupling. A 'fourth' observation is that lateral density contrasts and volatile migration during subduction and collision effectively refertilize mantle lithosphere, and pre-condition later tectonic cycles.
EXPLICIT ERROR ESTIMATE FOR THE NONCONFORMING WILSON'S ELEMENT
Institute of Scientific and Technical Information of China (English)
Jikun ZHAO; Shaochun CHEN
2013-01-01
In this article,we study the explicit expressions of the constants in the error estimate of the nonconforming finite element method.We explicitly obtain the approximation error estimate and the consistency error estimate for the Wilson's element without the regular assumption,respectively,which implies the final finite element error estimate.Such explicit a priori error estimates can be used as computable error bounds.
Darboux Transformation for Drinfel'd-Sokolov-Wilson Equation
Niu, Xiao-Xing; Liu, Qing-Ping
2015-11-01
A coupled system known as the Drinfel'd-Sokolov-Wilson equation is reexamined. With the help of a Lax operator of fourth order, its proper Darboux transformation is constructed. Also, a nonlinear superposition formula is worked out for the associated Bäcklund transformation and some solutions are calculated. Supported by the National Natural Science Foundation of China under Grant Nos. 11271366, 11331008 and 11401572, and the Fundamental Research Funds for Central Universities
Probing Wilson Loops in the QCD Instanton Vacuum
Liu, Yizhuang
2014-01-01
We discuss the quark and gluon condensates in the presence of a rectangular Wilson loop using the QCD instanton vacuum with three light dynamical quarks. The scalar quark condensate is found to decrease while the gluon condensate to increase. We also derive the static potential between two QCD dipoles and show that it is attractive but short ranged at large distances. Its relevance to static QCD string interactions is discussed.
Wilson's disease: an analysis of 28 Brazilian children
Directory of Open Access Journals (Sweden)
Rodolpho Truffa Kleine
2012-01-01
Full Text Available OBJECTIVES: Clinical-laboratory and evolutionary analysis of twenty-eight patients with Wilson's disease. METHODS: Twenty-eight children (twelve females and sixteen males with Wilson's disease were evaluated retrospectively between 1987 and 2009, with a follow-up of 72 months (1 - 240 months. The clinical, laboratory, and histologic features at diagnosis were recorded at the end of the study. RESULTS: The median age at diagnosis was 11 years (2 - 18 years. Twelve patients were asymptomatic, seven had hepatitis symptoms, five had raised aminotransferase levels, three had hepatomegaly associated with neurological disorders, one had fulminant hepatitis with hemolytic anemia, and six patients presented with a Kayser-Fleischer ring. A histological analysis revealed that six children had chronic hepatitis, seven had cirrhosis, two had steatosis, one had portal fibrosis, and one had massive necrosis. The treatment consisted of D-penicillamine associated with pyridoxine for 26 patients. Adverse effects were observed in the other two patients: one presented with uncontrollable vomiting and the other demonstrated elastosis perforans serpiginosa. At the end of the study, all 26 treated patients were asymptomatic. Twenty-four of the patients were treated with D-penicillamine and pyridoxine, and two were treated with trientine and zinc sulfate. A liver transplant was performed in one patient with fulminant hepatitis, but the final patient died 48 hours after admission to the intensive care unit. CONCLUSIONS: Family screenings associated with early treatment are important in preventing Wilson's disease symptoms and potentially fatal disease progression. The study suggests that Wilson's disease must be ruled out in children older than two years presenting with abnormal levels of hepatic enzymes because of the heterogeneity of symptoms and the encouraging treatment results obtained so far.
I=2 Pion Scattering Phase Shift with Wilson Fermions
:,; Fukugita, M; Hashimoto, S; Ishikawa, K-I; Ishizuka, N; Iwasaki, Y; Kanaya, K; Kaneko, T; Kuramashi, Y; Lesk, V; Okawa, M; Taniguchi, Y; Ukawa, A; Yoshié, T
2012-01-01
We present results of phase shift for I=2 $S$-wave $\\pi\\pi$ system with the Wilson fermions in the quenched approximation. The finite size method proposed by L\\"uscher is employed, and calculations are carried out at $\\beta=5.9$ ($a^{-1}=1.934(16)$ GeV from $m_\\rho$) on $24^3 \\times 60$, $32^3 \\times 60$, and $48^3 \\times 60$ lattices.
Using Wilson flow to study the SU(3) deconfinement transition
Datta, Saumen; Lytle, Andrew
2015-01-01
We explore the use of Wilson flow to study the deconfinement transition in SU(3) gauge theory. We use the flowed Polyakov loop as a renormalized order parameter for the transition, and use it to renormalize the Polyakov loop. We also study the flow properties of the electric and magnetic gluon condensates, and demonstrate that the difference of the flowed operators shows rapid change across the transition point.
Wilson flow and scale setting from lattice QCD
Bornyakov, V G; Hudspith, R; Nakamura, Y; Perlt, H; Pleiter, D; Rakow, P E L; Schierholz, G; Schiller, A; Stüben, H; Zanotti, J M
2015-01-01
We give a determination of the phenomenological value of the Wilson (or gradient) flow scales t0 and w0 for 2+1 flavours of dynamical quarks. The simulations are performed keeping the average quark mass constant, which allows the approach to the physical point to be made in a controlled manner. O(a) improved clover fermions are used and together with four lattice spacings this allows the continuum extrapolation to be taken.
Limiting Geometries of Two Circular Maldacena-Wilson Loop Operators
Arutyunov, G.; Plefka, J.; Staudacher, M.
2001-01-01
We further analyze a recent perturbative two-loop calculation of the expectation value of two axi-symmetric circular Maldacena-Wilson loops in [Script N] = 4 gauge theory. Firstly, it is demonstrated how to adapt the previous calculation of anti-symmetrically oriented circles to the symmetric case. By shrinking one of the circles to zero size we then explicitly work out the first few terms of the local operator expansion of the loop. Our calculations explicitly demonstrate that circular Mald...
Photometric Observations of 107P/Wilson-Harrington
Urakawa, Seitaro; Nishiyama, Kota; Sakamoto, Tsuyoshi; Takahashi, Noritsugu; Abe, Shinsuke; Ishiguro, Masateru; Kitazato, Kohei; Kuroda, Daisuke; Hasegawa, Sunao; Ohta, Kouji; Kawai, Nobuyuki; Shimizu, Yasuhiro; Nagayama, Shogo; Yanagisawa, Kenshi; Yoshida, Michitoshi; Yoshikawa, Makoto
2011-01-01
We present lightcurve observations and multiband photometry for 107P/Wilson-Harrington using five small- and medium-sized telescopes. The lightcurve has shown a periodicity of 0.2979 day (7.15 hour) and 0.0993 day (2.38 hour), which has a commensurability of 3:1. The physical properties of the lightcurve indicate two models: (1) 107P/Wilson-Harrington is a tumbling object with a sidereal rotation period of 0.2979 day and a precession period of 0.0993 day. The shape has a long axis mode (LAM) of L1:L2:L3 = 1.0:1.0:1.6. The direction of the total rotational angular momentum is around {\\lambda} = 310{\\deg}, {\\beta} = -10{\\deg}, or {\\lambda} = 132{\\deg}, {\\beta} = -17{\\deg}. The nutation angle is approximately constant at 65{\\deg}. (2) 107P/Wilson-Harrington is not a tumbler. The sidereal rotation period is 0.2979 day. The shape is nearly spherical but slightly hexagonal with a short axis mode (SAM) of L1:L2:L3 = 1.5:1.5:1.0. The pole orientation is around {\\lambda} = 330{\\deg}, {\\beta} = -27{\\deg}. In addition, ...
The epsilon regime with twisted mass Wilson fermions
Bar, Oliver; Shindler, Andrea
2010-01-01
We investigate the leading lattice spacing effects in mesonic two-point correlators computed with twisted mass Wilson fermions in the epsilon-regime. By generalizing the procedure already introduced for the untwisted Wilson chiral effective theory, we extend the continuum chiral epsilon expansion to twisted mass WChPT. We define different regimes, depending on the relative power counting for the quark masses and the lattice spacing. We explicitly compute, for arbitrary twist angle, the leading O(a^2) corrections appearing at NLO in the so-called GSM^* regime. As in untwisted WChPT, we find that in this situation the impact of explicit chiral symmetry breaking due to lattice artefacts is strongly suppressed. Of particular interest is the case of maximal twist, which corresponds to the setup usually adopted in lattice simulations with twisted mass Wilson fermions. The formulae we obtain can be matched to lattice data to extract physical low energy couplings, and to estimate systematic uncertainties coming from ...
Wilson Martins: between the intelligentsia and the university (1951
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Névio de Campos
2012-05-01
Full Text Available Abstract The purpose of this article is to analyze the presence of Ortega y Gasset in the Parana’s State group during the 1950s, especially his influence in the thinking of Wilson Martins, and to emphasize the debate on the ideas of the intellectual and the university. The article discusses about the contributions of this Parana’s thinker on the Parana’s university teaching constituting and organizing process, and emphasizes that the Wilson Martins’ role consisted in promoting the debate on the presence of the intellectual person in modern society, attributing the mission as guardian of the moral and herald of cultural renovation, without forgetting the Brazilian and European political-cultural context as the founding background to higher education. It bases itself on the speech entitled “The rebellion against intelligence and the mission of the university”, that occurred at the University of Parana in 1951, and on the work The History of Brazilian Intelligence, written by Wilson Martins.
Zinc acetate for the treatment of Wilson's disease.
Brewer, G J
2001-09-01
Zinc acetate (Galzin, Gate Pharmaceutical Co.) has been developed for the treatment of Wilson's disease, an inherited disease of copper accumulation and copper toxicity in brain and liver. Zinc acetate has been approved by the US FDA for maintenance therapy of adult and paediatric Wilson's disease patients but also has efficacy in the treatment of pregnant patients and presymptomatic patients from the beginning. It also has value as adjunctive therapy for the initial treatment of symptomatic patients. Zinc's mechanism of action involves induction of intestinal cell metallothionein (Mt), which blocks copper absorption from the intestinal track. A negative copper balance is caused by blockade not only of absorption of food copper but the blockade of reabsorption of the considerable amount of endogenously secreted copper in saliva, gastric juice and intestinal secretions. Zinc is completely effective in controlling copper levels and toxicity in Wilson's disease, as are other anticopper agents. Zinc's major advantage over other anticopper agents is its extremely low level of toxicity. The only side effect is some degree of initial gastric irritation in approximately10% of patients, which usually decreases and becomes insignificant over time. As with all long-term therapies, compliance is a problem in some patients and dictates regular monitoring with 24 h urine copper and zinc measurements. As with all anticopper therapies, over a long period of time, overtreatment and induction of copper deficiency can occur. This is to be avoided particularly in children because copper is required for growth.
Smooth Wilson loops in N=4 non-chiral superspace
Beisert, Niklas; Müller, Dennis; Plefka, Jan; Vergu, Cristian
2015-12-01
We consider a supersymmetric Wilson loop operator for 4d N = 4 super Yang-Mills theory which is the natural object dual to the AdS 5 × S 5 superstring in the AdS/CFT correspondence. It generalizes the traditional bosonic 1 /2 BPS Maldacena-Wilson loop operator and completes recent constructions in the literature to smooth (non-light-like) loops in the full N=4 non-chiral superspace. This Wilson loop operator enjoys global super-conformal and local kappa-symmetry of which a detailed discussion is given. Moreover, the finiteness of its vacuum expectation value is proven at leading order in perturbation theory. We determine the leading vacuum expectation value for general paths both at the component field level up to quartic order in anti-commuting coordinates and in the full non-chiral superspace in suitable gauges. Finally, we discuss loops built from quadric splines joined in such a way that the path derivatives are continuous at the intersection.
Smooth Wilson Loops in N=4 Non-Chiral Superspace
Beisert, Niklas; Plefka, Jan; Vergu, Cristian
2015-01-01
We consider a supersymmetric Wilson loop operator for 4d N=4 super Yang-Mills theory which is the natural object dual to the AdS_5 x S^5 superstring in the AdS/CFT correspondence. It generalizes the traditional bosonic 1/2 BPS Maldacena-Wilson loop operator and completes recent constructions in the literature to smooth (non-light-like) loops in the full N=4 non-chiral superspace. This Wilson loop operator enjoys global superconformal and local kappa-symmetry of which a detailed discussion is given. Moreover, the finiteness of its vacuum expectation value is proven at leading order in perturbation theory. We determine the leading vacuum expectation value for general paths both at the component field level up to quartic order in anti-commuting coordinates and in the full non-chiral superspace in suitable gauges. Finally, we discuss loops built from quadric splines joined in such a way that the path derivatives are continuous at the intersection.
Practical Computational Formula for Wilson's Central Terminal%实用WILSON'S中心电端计算公式
Institute of Scientific and Technical Information of China (English)
李亚林
2004-01-01
以电学中设零电位的原则推导Wilson's中心电端计算公式(Ⅰ+Ⅱ)/(3). 由Wilson's中心电端计算公式可分别推导出三种胸肢导联,即CR(胸-右上肢)=Uc-((Ⅰ+Ⅱ)/(3)-(Ⅰ+Ⅱ)/(3)),CL(胸-左上肢)= Uc-((Ⅰ+Ⅱ)/(3)+(Ⅰ-Ⅲ)/(3)),CF(胸-左下肢)=Uc-((Ⅰ+Ⅱ)/(3)+(Ⅱ+Ⅲ)/(3)).以软件的方式即可在计算机化的同步十二导心电图机上记录出同步的三种胸肢导联心电图.
Archetypal Dreams: the Quantum Theater of Robert Wilson
Dietrich, Dawn Yvette
1992-01-01
My topic is situated within the larger framework of interdisciplinary study currently exploring the impact of new physics on various "soft" disciplines and sciences. Aligning myself with thinkers like Fritjof Capra and N. Katherine Hayles, who argue that quantum mechanics has brought about a new paradigm for the conceptualization of the physical world and our relation to it, I demonstrate that there is a connection, a kind of cultural translation, which relates contemporary physics to some avant-garde theater. Specifically, I center my research on American theater designer, Robert Wilson, who, recognized for his manipulation of the formal elements of stagecraft, owes much to the reconstruction of principles governing space and time. Taken further, I maintain that it is through the paradigm established from relativity theory and quantum mechanics that Wilson experiments with the elementary "forces" of the theater itself. This "restructuring" occurs through the dramatist's conceptions of space and time and the relation of those properties to both performers and spectators. Unlike most conventional theater, but as in many contemporary visual arts, time is manipulated through spatial metaphors and events take place in an amplified space--effecting a kind of dramatic space/time. Through manipulation of scale, the exploration of discontinuous time, and segregated stage zones, Wilson demonstrates that theater time is fluid and that it is not necessary for dramatic action to take place within the unified stage space delineated by the proscenium itself. Unlike conventional theater, where the stage is constructed with one perspective in mind, Wilson's theatrical mise-en-scene--a kind of new "perceptual field"--requires "imaginative watching"; that is, more perceptual discrimination from the audience who must sort and organize the visual material, highlighting the essential while reconfiguring the incidental. And this is where the myth is born, where archetypal dreams stir
Doença de Wilson e Gravidez: Relato de Caso Pregnancy and Wilson's Disease: A Case Report
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Ana Paula Brito Hortêncio
2001-06-01
Full Text Available A doença de Wilson (degeneração hepatolenticular é distúrbio autossômico recessivo raro que usualmente ocorre entre a primeira e terceira décadas de vida. Caracteriza-se por depósito excessivo de cobre no fígado e cérebro e é fatal se não diagnosticada e tratada precocemente. Os autores descrevem um caso de gravidez e doença de Wilson, mostrando a evolução satisfatória de uma paciente que fez uso da D-penicilamina até a sétima semana de gestação, quando a suspendeu por conta própria, e após a vigésima semana gestacional. A mãe evoluiu sem sinais de descompensação clínica ou obstétrica. O recém-nascido não apresentou nenhuma intercorrência e encontrava-se bem no final do primeiro ano de vida.Wilson's disease (hepatolenticular degeneration is a rare autosomal recessive disorder that usually occurs between the first and third decades. The condition is characterized by excessive deposition of copper in the liver and brain. It is fatal if the diagnosis and treatment are not performed early in life. The authors describe one case of pregnancy and Wilson's disease, showing the good evolution of the patient, who used D-penicillamine until the seventh week of gestation, discontinuing thereafter until the 20th week of gestation. The mother evolved with no signs of clinic and obstetric problems. The newborn did not present any problem and was healthy in his first year of life.
Nussinson, Elchanan; Shahbari, Azmi; Shibli, Fahmi; Chervinsky, Elena; Trougouboff, Philippe; Markel, Arie
2013-11-27
Wilson's disease is a rare disorder of copper transport in hepatic cells, and may present as cholestatic liver disease; pancreatitis and cholangitis are rarely associated with Wilsons's disease. Moreover, cases of Wilson's disease presenting as pigmented gallstone pancreatitis have not been reported in the literature. In the present report, we describe a case of a 37-year-old man who was admitted with jaundice and abdominal pain. The patient was diagnosed with acute pancreatitis, cholangitis, and obstructive jaundice caused by pigmented gallstones that were detected during retrograde cholangiopancreatography. However, because of his long-term jaundice and the presence of pigmented gallstones, the patient underwent further evaluation for Wilson's disease, which was subsequently confirmed. This patient's unique presentation exemplifies the overlap in the clinical and laboratory parameters of Wilson's disease and cholestasis, and the difficulties associated with their differentiation. It suggests that Wilson's disease should be considered in patients with pancreatitis, cholangitis, and severe protracted jaundice caused by pigmented gallstones.
A Tale of Two Spaces: BPS Wilson Loops in Minkowski Spacetime and Euclidean Space
Ouyang, Hao; Zhang, Jia-ju
2015-01-01
We discuss BPS Wilson loops of $d=4$ $\\mathcal N=4$ super Yang-Mills theory, $d=3$ $\\mathcal N=2$ super Chern-Simons-matter theory, and $d=3$ $\\mathcal N=6$ Aharony-Bergman-Jafferis-Maldacena theory, in both Minkowski spacetime and Euclidean space. We find that there are timelike and null BPS Wilson loops in Minkowski spacetime, but spacelike BPS Wilson loops do not exist. We attribute this to the conflicts of reality conditions of spinors. However, in Euclidean space spacelike Wilson loops do exist. There are both Wilson lines of infinite straight lines and Wilson loops of circles. This is because the reality conditions of spinors are lost after Wick rotation. The result is reasonable in view of AdS/CFT correspondence.
Construction of novel BPS Wilson loops in three-dimensional quiver Chern-Simons-matter theories
Ouyang, Hao; Zhang, Jia-ju
2015-01-01
In this paper, we construct novel Drukker-Trancanelli (DT) type BPS Wilson loops along infinite straight lines in $\\mathcal N=2,3$ quiver super Chern-Simons-matter (CSM) theories, Aharony-Bergman-Jafferis-Maldacena (ABJM) theory, and $\\mathcal N=4$ orbifold ABJM theory. There are several free complex parameters in the DT type BPS Wilson loops, and for Wilson loops in ABJM theory and $\\mathcal N=4$ orbifold ABJM theory there are supersymmetry enhancements at special values of the parameters. We check that the differences of the DT type and Gaiotto-Yin (GY) type Wilson loops are $Q$-exact with $Q$ being some supercharges preserved by both the DT type and GY type Wilson loops. The results would be useful to calculate vacuum expectation values of the Wilson loops in matrix models if they are still BPS quantum mechanically.
The Jones polynomial: quantum algorithms and applications in quantum complexity theory
Yard, J; Yard, Jon; Wocjan, Pawel
2006-01-01
We analyze relationships between the Jones polynomial and quantum computation. Our first result is a polynomial-time quantum algorithm which gives an additive approximation of the Jones polynomial, in the sense of Bordewich, Freedman, Lovasz and Welsh, of any link obtained from a certain general family of closures of braids, evaluated at any primitive root of unity. This family encompasses the well-known plat and trace closures, generalizing results recently obtained by Aharonov, Jones and Landau. We base our algorithm on a local qubit implementation of the unitary Jones-Wenzl representations of the braid group which makes the underlying representation theory apparent, allowing us to provide an algorithm for approximating the HOMFLYPT two-variable polynomial of the trace closure of a braid at certain pairs of values as well. Next, we provide a self-contained proof that any quantum computation can be replaced by an additive approximation of the Jones polynomial, evaluated at almost any primitive root of unity....
Evaluation of anxiolytic activity of compound Valeriana jatamansi Jones in mice
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You Jie-Shu
2012-11-01
Full Text Available Abstract Background Compound Valeriana jatamansi Jones is a formula for treating anxiety-related diseases in the clinic, which is composed of Valeriana jatamansi Rhizoma et Radix, Ziziphi Spinosae Semen, Albiziae Cortex and Junci Medulla. The purpose of this study was to explore the anxiolytic properties of this compound in mice. Methods Male ICR mice were treated with compound Valerianae Jatamansi Jones (1.2 g/kg, 2.4 g/kg, 4.8 g/kg, saline, diazepam (2 mg/kg orally for 10 days and then exposed to elevated maze-plus (EPM and light–dark box (LDB. The effects of the compound on spontaneous activity were evaluated by locomotor activity test. We further investigated the mechanism of action underlying the anxiolytic-like effect of compound by pre-treating animals with antagonists of benzodiazepine (flumazenil, 3mg/kg prior to evaluation using EPM and LDB. Results Compound Valerianae Jatamansi Jones (2.4, 4.8 g/kg, p.o. significantly increased entries (PPPPP>0.05. In addition, compound Valerianae Jatamansi Jones treatment didn’t affect the spontaneous activity in mice (P> 0.05. Conclusions The present study supports the hypothesis that compound Valeriana jatamansi Jones exert anxiolytic action but no sedative effects in mice and that this effect might be mediated by benzodiazepine receptors.
Patel, Mayara Paim; Henriques, José Fernando Castanha; de Freitas, Karina Maria Salvatore; Grec, Roberto Henrique da Costa
2014-01-01
Objective The aim of this study was to cephalometrically assess the skeletal and dentoalveolar effects of Class II malocclusion treatment performed with the Jones Jig appliance followed by fixed appliances. Methods The sample comprised 25 patients with Class II malocclusion treated with the Jones Jig appliance followed by fixed appliances, at a mean initial age of 12.90 years old. The mean time of the entire orthodontic treatment was 3.89 years. The distalization phase lasted for 0.85 years, after which the fixed appliance was used for 3.04 years. Cephalograms were used at initial (T1), post-distalization (T2) and final phases of treatment (T3). For intragroup comparison of the three phases evaluated, dependent ANOVA and Tukey tests were used. Results Jones Jig appliance did not interfere in the maxillary and mandibular component and did not change maxillomandibular relationship. Jones Jig appliance promoted distalization of first molars with anchorage loss, mesialization and significant extrusion of first and second premolars, as well as a significant increase in anterior face height at the end of treatment. The majority of adverse effects that occur during intraoral distalization are subsequently corrected during corrective mechanics. Buccal inclination and protrusion of mandibular incisors were identified. By the end of treatment, correction of overjet and overbite was observed. Conclusions Jones Jig appliance promoted distalization of first molars with anchorage loss represented by significant mesial movement and extrusion of first and second premolars, in addition to a significant increase in anterior face height. PMID:25162565
Patel, Mayara Paim; Henriques, José Fernando Castanha; Freitas, Karina Maria Salvatore; Grec, Roberto Henrique da Costa
2014-01-01
The aim of this study was to cephalometrically assess the skeletal and dentoalveolar effects of Class II malocclusion treatment performed with the Jones Jig appliance followed by fixed appliances. The sample comprised 25 patients with Class II malocclusion treated with the Jones Jig appliance followed by fixed appliances, at a mean initial age of 12.90 years old. The mean time of the entire orthodontic treatment was 3.89 years. The distalization phase lasted for 0.85 years, after which the fixed appliance was used for 3.04 years. Cephalograms were used at initial (T1), post-distalization (T2) and final phases of treatment (T3). For intragroup comparison of the three phases evaluated, dependent ANOVA and Tukey tests were used. Jones Jig appliance did not interfere in the maxillary and mandibular component and did not change maxillomandibular relationship. Jones Jig appliance promoted distalization of first molars with anchorage loss, mesialization and significant extrusion of first and second premolars, as well as a significant increase in anterior face height at the end of treatment. The majority of adverse effects that occur during intraoral distalization are subsequently corrected during corrective mechanics. Buccal inclination and protrusion of mandibular incisors were identified. By the end of treatment, correction of overjet and overbite was observed. Jones Jig appliance promoted distalization of first molars with anchorage loss represented by significant mesial movement and extrusion of first and second premolars, in addition to a significant increase in anterior face height.
Park, Jongchan; Yu, Hyeonseung; Park, Jung-Hoon; Park, YongKeun
2014-10-06
We present measurements of the full Jones matrix of individual pixels in a liquid-crystal display (LCD) panel. Employing a polarization-sensitive digital holographic microscopy based on Mach-Zehnder interferometry, the complex amplitudes of the light passing through individual LCD pixels are precisely measured with respect to orthogonal bases of polarization states, from which the full Jones matrix components of individual pixels are obtained. We also measure the changes in the Jones matrix of individual LCD pixels with respect to an applied bias. In addition, the complex optical responses of a LCD panel with respect to arbitrary polarization states of incident light were characterized from the measured Jones matrix.
Topology, Random Matrix Theory and the spectrum of the Wilson Dirac operator
Deuzeman, Albert; Wuilloud, Jaïr
2011-01-01
We study the spectrum of the hermitian Wilson Dirac operator in the epsilon-regime of QCD in the quenched approximation and compare it to predictions from Wilson Random Matrix Theory. Using the distributions of single eigenvalues in the microscopic limit and for specific topological charge sectors, we examine the possibility of extracting estimates of the low energy constants which parametrise the lattice artefacts in Wilson chiral perturbation theory. The topological charge of the field configurations is obtained from a field theoretical definition as well as from the flow of eigenvalues of the hermitian Wilson Dirac operator, and we determine the extent to which the two are correlated.
[The onset of psychiatric disorders and Wilson's disease].
Benhamla, T; Tirouche, Y D; Abaoub-Germain, A; Theodore, F
2007-12-01
Wilson's disease is an infrequent, autosomic recessive pathology, resulting from a loss of function of an adenosine triphosphatase (ATP7B or WDNP), secondarily to a change (more than 60 are described currently), insertion or deletion of the ATP7B gene located on the chromosome 13q14.3-q21.1, which involves a reduction or an absence of the transport of copper in the bile and its accumulation in the body, notably the brain. Wilson's disease is transmitted by an autosomic recessive gene located on the long arm of chromosome 13. The prevalence of the heterozygote is evaluated at 1/90 and the homozygote at 1/30,000. Consanguinity, frequent in the socially geographically isolated populations, increases the prevalence of the disease. The toxic quantities of copper, which accumulate in the liver since early childhood and perhaps before, remain concentrated in the body for years. Hence, cytological and histological modifications can be detected in the biopsies, before the appearance of clinical or biological symptoms of hepatic damage. The accumulation of copper in the liver is due to a defect in the biliary excretion of metal and is accompanied invariably by a deficit in ceruloplasmin; protein synthesized from a transferred ATP7B gene, which causes retention of the copper ions in the liver. The detectable cellular anomalies are of two types: hepatic lesions resulting in acute hepatic insufficiency, acute hepatitis and finally advanced cirrhosis and lesions of the central nervous system responsible for the neurological and psychiatric disorders. In approximately 40-50% of the patients, the first manifestation of Wilson's disease affects the central nervous system. Although copper diffuses in the liver towards the blood and then towards other tissues, it has disastrous consequences only in the brain. It can therefore cause either a progressive neurological disease, or psychiatric disorders. Wilson's disease begins in the form of a hepatic, neurological, or psychiatric
Phase diagram of power law and Lennard-Jones systems: Crystal phases
Energy Technology Data Exchange (ETDEWEB)
Travesset, Alex [Ames Laboratory
2014-10-28
An extensive characterization of the low temperature phase diagram of particles interacting with power law or Lennard-Jones potentials is provided from Lattice Dynamical Theory. For power law systems, only two lattice structures are stable for certain values of the exponent (or softness) (A15, body centered cube (bcc)) and two more (face centered cubic (fcc), hexagonal close packed (hcp)) are always stable. Among them, only the fcc and bcc are equilibrium states. For Lennard-Jones systems, the equilibrium states are either hcp or fcc, with a coexistence curve in pressure and temperature that shows reentrant behavior. The hcp solid never coexists with the liquid. In all cases analyzed, for both power law and Lennard-Jones potentials, the fcc crystal has higher entropy than the hcp. The role of anharmonic terms is thoroughly analyzed and a general thermodynamic integration to account for them is proposed.
Advance in the pathogenesis and treatment of Wilson disease
2012-01-01
Wilson disease is an autosomal recessive disorder of copper metabolism. Diagnosis depends primarily on clinical features, biochemical parameters and the presence of the Kayser-Fleischer ring. Genetic analysis for mutations within ATP7B is a convincing diagnostic tool. The traditional treatment for WD includes chelation of excessive copper accumulation and reduction of copper intake. Medical therapy is effective but WD is not yet curable. Liver transplantation is especially helpful for patients who fail to respond to medical therapy or present with fulminant liver failure, although evaluation of its long-term effect are still in need. PMID:23210912
Current Drug Managements of Wilson's Disease: From West to East.
Li, Wen-Jie; Chen, Chen; You, Zhi-Fei; Yang, Ren-Min; Wang, Xiao-Ping
2016-01-01
Wilson's disease (WD), also called hepatolenticular degeneration, is an autosomal recessive inheritance disorder of copper metabolism characterized by the multiple mutations in the ATP-ase 7B gene of chromosome 13q. About half of the WD patients have neurological or psychiatric symptoms. As WD is a kind of medicable or nearly curable neurodegenerative disease in the field of medicine, early consideration/examination and without delay/ life-long treatment usually lead to better prognoses. The drugs, also named as anticopper agents, are commonly used in clinics including D-penicillamine, trientine, sodium dimercaptosuccinate, dimercaptosuccinic acid, zinc and tetrathiomolybdate. This provides detailed reviews about these medicines.
Generalized Wilson chain for solving multichannel quantum impurity problems
Mitchell, Andrew K.; Galpin, Martin R.; Wilson-Fletcher, Samuel; Logan, David E.; Bulla, Ralf
2014-03-01
The numerical renormalization group is used to solve quantum impurity problems, which describe magnetic impurities in metals, nanodevices, and correlated materials within dynamical mean field theory. Here we present a simple generalization of the Wilson chain, which improves the scaling of computational cost with the number of conduction bands, bringing more complex problems within reach. The method is applied to calculate the t matrix of the three-channel Kondo model at T =0, which shows universal crossovers near non-Fermi-liquid critical points. A nonintegrable three-impurity problem with three bands is also studied, revealing a rich phase diagram and novel screening and overscreening mechanisms.
Wilson fermions and axion electrodynamics in optical lattices.
Bermudez, A; Mazza, L; Rizzi, M; Goldman, N; Lewenstein, M; Martin-Delgado, M A
2010-11-05
We show that ultracold Fermi gases in optical superlattices can be used as quantum simulators of relativistic lattice fermions in 3+1 dimensions. By exploiting laser-assisted tunneling, we find an analogue of the so-called naive Dirac fermions, and thus provide a realization of the fermion doubling problem. Moreover, we show how to implement Wilson fermions, and discuss how their mass can be inverted by tuning the laser intensities. In this regime, our atomic gas corresponds to a phase of matter where Maxwell electrodynamics is replaced by axion electrodynamics: a 3D topological insulator.
Wilson flux breaking and coset space dimensional reduction
Energy Technology Data Exchange (ETDEWEB)
Zoupanos, G.
1988-02-11
Higher dimensional gauge theories lead, after dimensional reduction on coset spaces, to four-dimensional gauge theories usually with the natural emergence of a Higgs sector which is completely determined. However, the Higgs fields never appear in the adjoint representation which in many GUTs could lead to a successful spontaneous symmetry breaking towards the low energy gauge group. As an alternative we suggest that the breaking of the four-dimensional GUTs obtained from CSDR could be provided by the Wilson flux breaking and we discuss some semirealistic examples. We also speculate on the possibility that the breaking of the electroweak sector has dynamical origin.
Dual conformal transformations of smooth holographic Wilson loops
Dekel, Amit
2016-01-01
We study dual conformal transformations of minimal area surfaces in $AdS_5 \\times S^5$ corresponding to holographic smooth Wilson loops and some other related observables. To act with dual conformal transformations we map the string solutions to the dual space by means of T-duality, then we apply a conformal transformation and finally T-dualize back to the original space. The transformation maps between string solutions with different boundary contours. The boundary contours of the minimal surfaces are not mapped back to the AdS boundary, and the regularized area of the surface changes.
Advance in the pathogenesis and treatment of Wilson disease
Directory of Open Access Journals (Sweden)
Dong Qin-Yun
2012-11-01
Full Text Available Abstract Wilson disease is an autosomal recessive disorder of copper metabolism. Diagnosis depends primarily on clinical features, biochemical parameters and the presence of the Kayser-Fleischer ring. Genetic analysis for mutations within ATP7B is a convincing diagnostic tool. The traditional treatment for WD includes chelation of excessive copper accumulation and reduction of copper intake. Medical therapy is effective but WD is not yet curable. Liver transplantation is especially helpful for patients who fail to respond to medical therapy or present with fulminant liver failure, although evaluation of its long-term effect are still in need.
Critical behavior of the Schwinger model with Wilson fermions
Azcoiti, V; Galante, A; Grillo, A F; Laliena, V
1996-01-01
We present a detailed analysis, in the framework of the MFA approach of the critical behaviour of the lattice Schwinger model with Wilson fermions on lattices up to 24^2, through the study of the Lee-Yang zeros and the specific heat. We find compelling evidence for a critical line ending at \\kappa = 0.25 at large \\beta. Finite size scaling analysis on lattices 8^2,12^2,16^2, 20^2 and 24^2 indicates a continuous transition. The hyperscaling relation is verified in the explored \\beta region.
Ward identities and Wilson renormalization group for QED
Bonini, M; Marchesini, G
1994-01-01
We analyze a formulation of QED based on the Wilson renormalization group. Although the ``effective Lagrangian'' used at any given scale does not have simple gauge symmetry, we show that the resulting renormalized Green's functions correctly satisfies Ward identities to all orders in perturbation theory. The loop expansion is obtained by solving iteratively the Polchinski's renormalization group equation. We also give a new simple proof of perturbative renormalizability. The subtractions in the Feynman graphs and the corresponding counterterms are generated in the process of fixing the physical conditions.
Poisson Brackets of Normal-Ordered Wilson Loops
Lee, C. -W. H.; Rajeev, S. G.
1998-01-01
We formulate Yang-Mills theory in terms of the large-N limit, viewed as a classical limit, of gauge-invariant dynamical variables, which are closely related to Wilson loops, via deformation quantization. We obtain a Poisson algebra of these dynamical variables corresponding to normal-ordered quantum (at a finite value of $\\hbar$) operators. Comparing with a Poisson algebra one of us introduced in the past for Weyl-ordered quantum operators, we find, using ideas closly related to topological g...
Ward identities and Wilson renormalization group for QED
Bonini, M.; D'Attanasio, M.; Marchesini, G.
1994-04-01
We analyze a formulation of QED based on the Wilson renormalization group. Although the "effective lagrangian" used at any given scale does not have simple gauge symmetry, we show that the resulting renormalized Green's function correctly satisfies Ward identities to all orders in perturbation theory. The loop expansion is obtained by solving iteratively the Polchinski renormalization group equation. We also give a new simple proof of perturbative renormalizability. The subtractions in the Feynman graphs and the corresponing counter-terms are generated in the process of fixing the physical conditions.
Renormalization of Wilson Operators in the Light-Cone Gauge
Andrasi, A
2001-01-01
We test the renormalization of Wilson operators and the Mandelstam- Leibbrandt gauge in the case when the sides of the loop are parallel to the n, n* vectors used in the M-L gauge. Graphs which in the Feynman gauge are free of ultra-violet divergences, in the M-L gauge show double divergences and single divergences with non-local si and ci functions. In Appendix C we briefly discuss the problems of the M-L gauge for loops containing spacelike lines.
Poisson brackets of normal-ordered Wilson loops
Lee, C.-W. H.; Rajeev, S. G.
1999-04-01
We formulate Yang-Mills theory in terms of the large-N limit, viewed as a classical limit, of gauge-invariant dynamical variables, which are closely related to Wilson loops, via deformation quantization. We obtain a Poisson algebra of these dynamical variables corresponding to normal-ordered quantum (at a finite value of ℏ) operators. Comparing with a Poisson algebra one of us introduced in the past for Weyl-ordered quantum operators, we find, using ideas closely related to topological graph theory, that these two Poisson algebras are, roughly speaking, the same. More precisely speaking, there exists an invertible Poisson morphism between them.
The algebra of Wilson-'t Hooft operators
Energy Technology Data Exchange (ETDEWEB)
Kapustin, Anton [California Institute of Technology, Pasadena, CA 91125 (United States); Saulina, Natalia [California Institute of Technology, Pasadena, CA 91125 (United States)], E-mail: saulina@theory.caltech.edu
2009-06-11
We study the Operator Product Expansion of Wilson-'t Hooft operators in a twisted N=4 super-Yang-Mills theory with gauge group G. The Montonen-Olive duality puts strong constraints on the OPE and in the case G=SU(2) completely determines it. From the mathematical point of view, the Montonen-Olive duality predicts the L{sup 2} Dolbeault cohomology of certain equivariant vector bundles on Schubert cells in the affine Grassmannian. We verify some of these predictions. We also make some general observations about higher categories and defects in Topological Field Theorie000.
Wilson loop expectations in $SU(N)$ lattice gauge theory
Jafarov, Jafar
2016-01-01
This article gives a rigorous formulation and proof of the $1/N$ expansion for Wilson loop expectations in strongly coupled $SU(N)$ lattice gauge theory in any dimension. The coefficients of the expansion are represented as absolutely convergent sums over trajectories in a string theory on the lattice, establishing a kind of gauge-string duality. Moreover, it is shown that in large $N$ limit, calculations in $SU(N)$ lattice gauge theory with coupling strength $2\\beta$ corresponds to those in $SO(N)$ lattice gauge theory with coupling strength $\\beta$ when $|\\beta|$ is sufficiently small.
Wilson loops at strong coupling for curved contours with cusps
Dorn, Harald
2015-01-01
We construct the minimal surface in AdS, relevant for the strong coupling behaviour of local supersymmetric Wilson loops in N=4 SYM for a closed contour formed out of segments of two intersecting circles. Its regularised area is calculated including all divergent parts and the finite renormalised term. Furthermore we prove, that for generic planar curved contours with cusps the cusp anomalous dimensions are functions of the respective cusp angles alone. They do not depend on other local data of the cusps.
Large-N reduction with adjoint Wilson fermions
Bringoltz, Barak; Sharpe, Stephen R
2012-01-01
We analyze the large-N behavior of SU(N) lattice gauge theories with adjoint fermions by studying volume-reduced models, as pioneered by Eguchi and Kawai. We perform simulations on a single-site lattice for Nf = 1 and Nf = 2 Wilson Dirac fermions with values of N up to 53. We show for both values of Nf that in the large-N limit there is a finite region, containing both light and heavy fermions, of unbroken center symmetry where the theory exhibits volume independence. Using large-N reduction we attempt to calculate physical quantities such as the string tension and meson masses.
B-physics with $N_f=2$ Wilson fermions
Bernardoni, F; Bulava, J; Della Morte, M; Fritzsch, P; Garron, N; Gerardin, A; Heitger, J; von Hippel, G; Simma, H; Sommer, R
2014-01-01
We report the final results of the ALPHA collaboration for some B-physics observables: $f_B$, $f_{B_s}$ and $m_b$. We employ CLS configurations with 2 flavors of $O(a)$ improved Wilson fermions in the sea and pion masses ranging down to 190 MeV. The b-quark is treated in HQET to order $1/m_b$. The renormalization, the matching and the improvement were performed non-perturbatively, and three lattice spacings reaching $a=0.048$ fm are used in the continuum extrapolation.
The Nambu Jona-Lasinio model with Wilson fermions
Rantaharju, Jarno
2017-01-01
We present a lattice study of a Nambu Jona-Lasinio (NJL) model using Wilson fermions. Four fermion interactions are a natural part of several extensions of the Standard Model, appearing as a low energy description of a more fundamental theory. In models of dynamical electroweak symmetry breaking they are used to endow the Standard Model fermions with masses. In infrared conformal models these interaction, when sufficiently strong, can alter the dynamics of the fixed point, turning the theory into a (near) conformal model with desirable features for model building. As a first step toward the nonperturbative study of these models, we study the phase space of the ungauged NJL model.
Research of Wilson-θ Method Used in Seismic Applications%Wilson-θ方法在结构动力分析中的应用研究
Institute of Scientific and Technical Information of China (English)
马小燕; 王一兵
2003-01-01
介绍了逐步积分Wilson-θ方法在砖混建筑结构动力分析中的应用.通过对单质点结构剪切模型在正弦激励下的模拟计算,研究Wilson-θ方法中各参数对该方法计算精度的影响.提出Wilson-θ方法适合砖混建筑结构动力分析的最优参数选择.
Return to Play and Performance After Jones Fracture in National Basketball Association Athletes.
Begly, John P; Guss, Michael; Ramme, Austin J; Karia, Raj; Meislin, Robert J
2016-07-01
Basketball players are at risk for foot injuries, including Jones fractures. It is unknown how this injury affects the future play and performance of athletes. National Basketball Association (NBA) players who sustain Jones fractures of the base of the fifth metatarsal have high rates of return to play and do not experience a decrease in performance on return to competition when compared with preinjury and with control-matched peers. Retrospective cohort study. Level 5. Data on 26 elite basketball players with Jones fractures over 19 NBA seasons (1994-1995 to 2012-2013) were obtained from injury reports, press releases, player profiles, and online public databases. Variables included age, body mass index (BMI), player position, experience, and surgical treatment. Individual season statistics pre- and postinjury were collected. Twenty-six controls were identified by matched player position, age, and performance statistics. The mean age at the time of injury was 24.8 years, mean BMI was 24.7 kg/m(2), and the mean experience prior to injury was 4.1 NBA seasons. Return to previous level of competition was achieved by 85% of athletes. There was no change in player efficiency rating (PER) when pre- and postinjury performance was compared. When compared with controls, no decline in PER measured performance was identified. The majority of NBA players sustaining a Jones fracture return to their preinjury level of competition. These elite athletes demonstrate no decrease in performance on their return to play. Jones fractures are well-studied injuries in terms of etiology, diagnosis, and management. However, the effect of these injuries on future performance of athletes is unknown. Using the findings of our study, orthopaedic surgeons may be better prepared to counsel and educate elite athletes who sustain a Jones fracture. © 2015 The Author(s).
Gingival Enlargement in a Case of Variant Jones Syndrome: a Case Report
Directory of Open Access Journals (Sweden)
Roopa DA
2016-03-01
Full Text Available Gingival enlargement can be caused by a variety of etiological factors like inflammation, drugs, and systemic diseases or can be presented as a part of a syndrome. One such syndrome is Jones Syndrome, which is associated with gingival enlargement and progressive hearing loss. We present here a case of fifteen-year-old boy with gingival enlargement, hearing loss, and generalized alveolar bone loss and diagnosed as Jones syndrome. The diagnosis was made based on history, clinical, radiographic, and histopathological findings. Gingival enlargement was surgically managed using gingivectomy and no recurrence was observed. The patient showed remarkable esthetical and functional improvement.
Gingival Enlargement in a Case of Variant Jones Syndrome: a Case Report
DA, Roopa; Singh, Shinkhala; Gupta, Ira; Gopal, Saumiya
2016-01-01
Gingival enlargement can be caused by a variety of etiological factors like inflammation, drugs, and systemic diseases or can be presented as a part of a syndrome. One such syndrome is Jones Syndrome, which is associated with gingival enlargement and progressive hearing loss. We present here a case of fifteen-year-old boy with gingival enlargement, hearing loss, and generalized alveolar bone loss and diagnosed as Jones syndrome. The diagnosis was made based on history, clinical, radiographic, and histopathological findings. Gingival enlargement was surgically managed using gingivectomy and no recurrence was observed. The patient showed remarkable esthetical and functional improvement. PMID:26966711
The SL_3 Jones polynomial of the trefoil: a case study of $q$-holonomic recursions
Garoufalidis, Stavros
2010-01-01
The SL_3 colored Jones polynomial of the trefoil knot is a $q$-holonomic sequence of two variables with natural origin, namely quantum topology. The paper presents an explicit set of generators for the annihilator ideal of this $q$-holonomic sequence as a case study. On the one hand, our results are new and useful to quantum topology: this is the first example of a rank 2 Lie algebra computation concerning the colored Jones polynomial of a knot. On the other hand, this work illustrates the applicability and computational power of the employed computer algebra methods.
Hunt, Kenneth; Goeb, Yannick
2016-01-01
Objectives: Fractures of the proximal metaphysis of the fifth metatarsal (i.e., Jones fractures) are common in the athletic population and frequently require surgical fixation to optimize healing rates and return to sport. Subtle hindfoot varus alignment, which likely results in greater forces at the fifth metatarsal, has been associated with increased risk of Jones fractures due to presumed increase in forces on the lateral foot. The goal of the present study was to dynamically assess plantar pressure loads at the fifth metatarsal in elite athletes with a history of Jones fracture. We hypothesize that athletes who have suffered Jones fractures will apply significantly higher loads at the fifth metatarsal base during athletic activities compared to matched uninjured athletes. Methods: Sixteen elite, competitive athletes were recruited to participate. Eight athletes had a history of Jones fracture and eight age, gender and position-matched athletes without a history of foot injury were recruited as controls. While wearing calibrated, wireless pressure mapping insoles, all athletes performed a standardized series of athletic movements including walking, running and cutting. Tests were repeated with the patient’s standard corrective insole. Peak pressure, mean pressure, maximum force, and force-time integral (i.e., impulse) were recorded for each activity. Comparison between groups was performed using a paired Wilcoxon Sign Rank test. Results: Athletes with a history of Jones fracture showed a significantly increased peak pressure (183 ±23 kPA vs. 138±7 kPA), mean pressure (124±14 kPA vs. 95±4 kPA), and maximum force (15±1.2%BW vs. 12±1.2%BW) at the fifth metatarsal base during walking and running compared to uninjured matched controls (all Pinsole did not significantly reduce peak or mean pressure, maximum force, or impulse at the fifth metatarsal base during running or cutting. Conclusion: Athletes with a history of Jones fracture exert significantly
1919: psychology and psychoanalysis, Cambridge and London - Myers, Jones and MacCurdy.
Forrester, John
2008-01-01
Viewing the reception of psychoanalysis in Britain from Cambridge, the paper examines the intertwining histories of the post-War British Psychological Society and the founding of the British Psycho-Analytical Society, following the initiatives of the two principal psychological entrepreneurs of the era, Charles Myers and Ernest Jones, Reforms in Cambridge in which psychoanalysis played a significant part are analysed, including the foundation of a Clinic for Nervous Diseases and the establishment of a separate Department of Experimental Psychology. The career of J. T. MacCurdy, Jones's student and Lecturer in Psychopathology at Cambridge, is discussed.
Fine-Tuning the Wilson-Bappu Effect
Gomez, T.; Wallerstein, G.
2011-12-01
We have used the re-reduced Hipparcos parallaxes and extensive new observations from various sources to investigate the details of the Ca II emission line width vs. Mv relation first noted in Wilson & Vainu Bappu (1957). Only stars whose parallaxes exceed their probably error by at least a factor of 5 were used. The full range of Mv now extends from Mv =+14 to -5. Small but well defined deviations from a linear relationship are clearly present. The data have also been separately plotted for each luminosity class from V to Ib. Main sequence stars show significant curvature from Mv = 14 to 8. Stars of class III show a very nice linear curve. The supergiants, almost all of which are of class Ib, show the greatest scatter as originally noted by Wallerstein et al. (1999). For those stars the Wilson-Bappu Effect is not a useful method for deriving Mv. We discus the shape of the dispersion in log W0 at a given Mv and show that it is asymmetric. Individual measurements of logW0 are more likely to be above the mean rather than below it. This is probably due to intermittent activity that enhances the width of the Ca II emission line.
A case of Wilson's disease with characteristic laparoscopic findings.
Muro, Shin-Ichiro; Yasunaka, Tetsuya; Wada, Nozomu; Morimoto, Yuki; Ikeda, Fusao; Shiraha, Hidenori; Takaki, Akinobu; Noso, Kazuhiro; Iwasaki, Hiroaki; Yamamoto, Kazuhide
2014-04-01
A 44-year-old male was pointed out liver function abnormality by medical check-up. Blood examination and computed tomography showed liver cirrhosis. Then, he was referred to our hospital for further examination. After blood test, viral markers revealed previous infection of hepatitis B virus (HBV). We estimated the etiology of his liver disease as previous HBV infection. On laparoscopic examination, his liver surface was nodular with mixed yellowish nodules and ash gray to copper-colored nodules in the diameter of 3-10 mm. There were large regenerative nodules in segments 3 and 4. Large regenerative nodules and irregular steatosis were contradictory to HBV-related liver cirrhosis, so then we supposed Wilson's disease. The amount of copper excretion in the urine was 326.6 μg (>100 μg/24 h). After D-penicillamine administration, urinary copper excretion increased to 2151.5 μg/24 h. Though hepatic copper concentration was 174.5 μg/g wet tissue (>200 μg/g wet tissue), his laboratory data fulfilled the Leipzig diagnostic criteria proposed by EASL. Laparoscopic examination with liver biopsy has advantages to survey many disease-specific findings on liver surface and to obtain adequate liver sample. Laparoscopic examination is one of the effective procedures for diagnosing relatively rare liver disease like Wilson's disease.
Infinite N phase transitions in continuum Wilson loop operators
Narayanan, R
2006-01-01
We define smoothed Wilson loop operators on a four dimensional lattice and check numerically that they have a finite and nontrivial continuum limit. The continuum operators maintain their character as unitary matrices and undergo a phase transition at infinite N reflected by the eigenvalue distribution closing a gap in its spectrum when the defining smooth loop is dilated from a small size to a large one. If this large N phase transition belongs to a solvable universality class one might be able to calculate analytically the string tension in terms of the perturbative Lambda-parameter. This would be achieved by matching instanton results for small loops to the relevant large-N-universal function which, in turn, would be matched for large loops to an effective string theory. Similarities between our findings and known analytical results in two dimensional space-time indicate that the phase transitions we found only affect the eigenvalue distribution, but the traces of finite powers of the Wilson loop operators...
Chelating polymeric beads as potential therapeutics for Wilson's disease.
Mattová, Jana; Poučková, Pavla; Kučka, Jan; Skodová, Michaela; Vetrík, Miroslav; Stěpánek, Petr; Urbánek, Petr; Petřík, Miloš; Nový, Zbyněk; Hrubý, Martin
2014-10-01
Wilson's disease is a genetic disorder caused by a malfunction of ATPase 7B that leads to high accumulation of copper in the organism and consequent toxic effects. We propose a gentle therapy to eliminate the excessive copper content with oral administration of insoluble non-resorbable polymer sorbents containing selective chelating groups for copper(II). Polymeric beads with the chelating agents triethylenetetramine, N,N-di(2-pyridylmethyl)amine, and 8-hydroxyquinoline (8HQB) were investigated. In a preliminary copper uptake experiment, we found that 8HQB significantly reduced copper uptake (using copper-64 as a radiotracer) after oral administration in Wistar rats. Furthermore, we measured organ radioactivity in rats to demonstrate that 8HQB radiolabelled with iodine-125 is not absorbed from the gastrointestinal tract after oral administration. Non-resorbability and the blockade of copper uptake were also confirmed with small animal imaging (PET/CT) in mice. In a long-term experiment with Wistar rats fed a diet containing the polymers, we have found that there were no signs of polymer toxicity and the addition of polymers to the diet led to a significant reduction in the copper contents in the kidneys, brains, and livers of the rats. We have shown that polymers containing specific ligands could potentially be novel therapeutics for Wilson's disease.
Renormalization constants of local operators for Wilson type improved fermions
Alexandrou, C; Korzec, T; Panagopoulos, H; Stylianou, F
2012-01-01
Perturbative and non-perturbative results are presented on the renormalization constants of the quark field and the vector, axial-vector, pseudoscalar, scalar and tensor currents. The perturbative computation, carried out at one-loop level and up to second order in the lattice spacing, is performed for a fermion action, which includes the clover term and the twisted mass parameter yielding results that are applicable for unimproved Wilson fermions, as well as for improved clover and twisted mass fermions. We consider ten variants of the Symanzik improved gauge action corresponding to ten different values of the plaquette coefficients. Non-perturbative results are obtained using the twisted mass Wilson fermion formulation employing two degenerate dynamical quarks and the tree-level Symanzik improved gluon action. The simulations are performed for pion masses in the range of 480 MeV to 260 MeV and at three values of the lattice spacing, a, corresponding to beta=3.9, 4.05, 4.20. For each renormalization factor c...
Linking the Wilson Cycle to deep Earth processes (Invited)
Torsvik, T. H.; Burke, K. C.
2010-12-01
Over the past century description of the movement and deformation of the Earth's outer layer has evolved from the hypothesis of Continental Drift into Sea-Floor Spreading and thence to the theory of Plate Tectonics. This theory is as fundamentally unifying to the Earth Sciences as Darwin's Evolution Theory is to Life Science. By 1968 Tuzo Wilson had identified three basic elements of geodynamics: plate tectonics, mantle plumes of deep origin and the Wilson cycle of ocean opening and closing, which provides evidence of plate tectonic behavior in times before quantifiable plate rotations. We have recently shown that deep-seated plumes of the past have risen only from narrow plume generation zones (PGZs) at the Core Mantle Boundary and mostly on the edges of two Large Low Shear wave Velocity Provinces (LLSVPs) that have been stable, antipodal and equatorial in their present positions for hundreds of millions of years and perhaps for much longer. Even though links between mantle activity and plate tectonics are becoming more evident, notably through subsurface tomographic images, advances in mineral physics and much improved absolute plate motion reference frames, a need now is to generate a new Earth model embodying plate tectonics, shallow and deep mantle convection, including such elements as deeply subducted slabs and stable LLSVPs with plumes that rise only from PGZs on the CMB.
Interest rates in quantum finance: the Wilson expansion and Hamiltonian.
Baaquie, Belal E
2009-10-01
Interest rate instruments form a major component of the capital markets. The Libor market model (LMM) is the finance industry standard interest rate model for both Libor and Euribor, which are the most important interest rates. The quantum finance formulation of the Libor market model is given in this paper and leads to a key generalization: all the Libors, for different future times, are imperfectly correlated. A key difference between a forward interest rate model and the LMM lies in the fact that the LMM is calibrated directly from the observed market interest rates. The short distance Wilson expansion [Phys. Rev. 179, 1499 (1969)] of a Gaussian quantum field is shown to provide the generalization of Ito calculus; in particular, the Wilson expansion of the Gaussian quantum field A(t,x) driving the Libors yields a derivation of the Libor drift term that incorporates imperfect correlations of the different Libors. The logarithm of Libor phi(t,x) is defined and provides an efficient and compact representation of the quantum field theory of the Libor market model. The Lagrangian and Feynman path integrals of the Libor market model of interest rates are obtained, as well as a derivation given by its Hamiltonian. The Hamiltonian formulation of the martingale condition provides an exact solution for the nonlinear drift of the Libor market model. The quantum finance formulation of the LMM is shown to reduce to the industry standard Bruce-Gatarek-Musiela-Jamshidian model when the forward interest rates are taken to be exactly correlated.
Treatment of Wilson's disease with zinc: X. Intestinal metallothionein induction.
Yuzbasiyan-Gurkan, V; Grider, A; Nostrant, T; Cousins, R J; Brewer, G J
1992-09-01
Oral zinc therapy is effective in controlling copper balance in patients with Wilson's disease and blocks the intestinal absorption of copper, as demonstrated by uptake of copper 64 and copper balance measurements. In this study, 64Cu uptake measurements were concomitantly carried out with intestinal biopsies to investigate the relationship of reduced copper absorption to the levels of intestinal metallothionein in patients with Wilson's disease at different stages of zinc therapy. A pronounced increase in intestinal metallothionein levels and a sharp drop in 64Cu absorption were found 4 to 5 days after the initiation of zinc treatment. Conversely, metallothionein levels decreased and 64Cu uptake increased on the discontinuation of zinc therapy. The data indicate that 64Cu absorption varies as a function of intestinal metallothionein level. Intestinal metallothionein levels were found to correlate linearly with urinary zinc levels, which reflect body zinc status. These findings support our hypothesis that intestinal metallothionein induction mediates decreased copper absorption observed during zinc therapy. The suppressive effect of zinc on copper absorption appears to have a half-life of about 11 days.
Wilson-Bappu Effect: Extended to Surface Gravity
Park, Sunkyung; Lee, Jeong-Eun; Lee, Sang-Gak
2013-01-01
Wilson and Bappu found a tight correlation between the stellar absolute visual magnitude (Mv) and the width of the Ca II K emission line for late-type stars in 1957. Here, we revisit the Wilson-Bappu relationship (hereafter, WBR) to claim that WBR can be an excellent indicator of stellar surface gravity of late-type stars as well as a distance indicator. We have measured the width (W) of the Ca II K emission line in high resolution spectra of 125 late-type stars, which were obtained with Bohyunsan Optical Echelle Spectrograph (BOES) and adopted from the UVES archive. Based on our measurement of the emission line width (W), we have obtained a WBR of Mv = 33.76 - 18.08 logW. In order to extend the WBR to be a surface gravity indicator, the stellar atmospheric parameters such as effective temperature (Teff), surface gravity (logg), metallicity ([Fe/H]), and micro-turbulence ($\\xi_{tur}$) have been derived from the self-consistent detailed analysis using the Kurucz stellar atmospheric model and the abundance anal...
Treatment of Wilson's disease with zinc. XVII: treatment during pregnancy.
Brewer, G J; Johnson, V D; Dick, R D; Hedera, P; Fink, J K; Kluin, K J
2000-02-01
Therapy of Wilson's disease continues to evolve. In 1997, zinc acetate was added to the list of drugs approved by the Food and Drug Administration, which includes penicillamine and trientine. The mechanism of zinc's anticopper action is unique. It induces intestinal cell metallothionein, which binds copper and prevents its transfer into blood. As intestinal cells die and slough, the contained copper is eliminated in the stool. Thus, zinc prevents the intestinal absorption of copper. It is universally agreed that pregnant Wilson's disease patients should remain on anticopper therapy during pregnancy. There are numerous reports of such patients stopping penicillamine therapy to protect their fetus from teratogenicity, only to undergo serious deterioration and even death from renewed copper toxicity. Penicillamine and trientine have teratogenic effects in animals, and penicillamine has known teratogenic effects in humans. In this report we discuss the results of 26 pregnancies in 19 women who were on zinc therapy throughout their pregnancy. The evidence is good that zinc protects the health of the mother during pregnancy. Fetal outcomes were generally quite good, although one baby had a surgically correctable heart defect and one had microcephaly.
A family study of the biochemical defects in Wilson's disease.
Soothill, J F; Blainey, J D; Neale, F C; Fischer-Williams, M; Melnick, S C
1961-05-01
Estimations of serum copper, serum ceruloplasmin (immunochemical), and urinary amino-acids excretion (quantitative and chromatographic) in 44 healthy relatives of patients with Wilson's disease (39 from one family) are reported. Each technique revealed some abnormal individuals. Good agreement was obtained between the serum copper and serum ceruloplasmin estimations and between the quantitative and chromatographic estimations of amino-acid excretion. Some individuals were abnormal to one or other of the pairs of tests only. These results cast doubt on the hypothesis that the symptoms of Wilson's disease are secondary to a quantitative (or qualitative) abnormality of ceruloplasmin. They also suggest that the mode of inheritance of the biochemical defects may be more complicated than that of a simple recessive mutant gene. Two of the relatives (one pregnant and one immediately post-partum) had a high serum copper level, as is expected in pregnancy, but normal serum ceruloplasmin. This suggests that the mechanism of control of the serum ceruloplasmin concentration may, normally, depend on the serum copper concentration.
Intestinal expression of metal transporters in Wilson's disease.
Przybyłkowski, Adam; Gromadzka, Grażyna; Wawer, Adriana; Grygorowicz, Tomasz; Cybulska, Anna; Członkowska, Anna
2013-12-01
In Wilson's disease (WND), biallelic ATP7B gene mutation is responsible for pathological copper accumulation in the liver, brain and other organs. It has been proposed that copper transporter 1 (CTR1) and the divalent metal transporter 1 (DMT1) translocate copper across the human intestinal epithelium, while Cu-ATPases: ATP7A and ATP7B serve as copper efflux pumps. In this study, we investigated the expression of CTR1, DMT1 and ATP7A in the intestines of both WND patients and healthy controls to examine whether any adaptive mechanisms to systemic copper overload function in the enterocytes. Duodenal biopsy samples were taken from 108 patients with Wilson's disease and from 90 controls. CTR1, DMT1, ATP7A and ATP7B expression was assessed by polymerase chain reaction and Western blot. Duodenal CTR1 mRNA and protein expression was decreased in WND patients in comparison to control subjects, while ATP7A mRNA and protein production was increased. The variable expression of copper transporters may serve as a defense mechanism against systemic copper overload resulting from functional impairment of ATP7B.
Integrability of smooth Wilson loops in N=4 superspace
Beisert, Niklas; Müller, Dennis; Plefka, Jan; Vergu, Cristian
2015-12-01
We perform a detailed study of the Yangian symmetry of smooth supersymmetric Maldacena-Wilson loops in planar N=4 super Yang-Mills theory. This hidden symmetry extends the global superconformal symmetry present for these observables. A gauge-covariant action of the Yangian generators on the Wilson line is established that generalizes previous constructions built upon path variations. Employing these generators the Yangian symmetry is proven for general paths in non-chiral N=4 superspace at the first perturbative order. The bi-local piece of the level-one generators requires the use of a regulator due to divergences in the coincidence limit. We perform regularization by point splitting in detail, thereby constructing additional local and boundary contributions as regularization for all level-one Yangian generators. Moreover, the Yangian algebra at level one is checked and compatibility with local kappa-symmetry is established. Finally, the consistency of the Yangian symmetry is shown to depend on two properties: the vanishing of the dual Coxeter number of the underlying superconformal algebra and the existence of a novel superspace "G-identity" for the gauge field theory. This tightly constrains the conformal gauge theories to which integrability can possibly apply.
The Cultural Origins and Play Philosophy of Playworkers: An Interview with Penny Wilson
American Journal of Play, 2009
2009-01-01
Penny Wilson is a playworker--one of a group of professionals who facilitate children's play in adventure playgrounds, parks, and other settings, principally in the United Kingdom. Wilson grew up in the Southeast of England and spent much of her childhood playing on the coast near her family home. She studied illustration in art school, settled in…
On the Anti-slavery Theme and Great Humor in Pudd'nhead Wilson
Institute of Scientific and Technical Information of China (English)
谢争艳
2015-01-01
Pudd'nhead Wilson is an excellent novel of Mark Twain.Mark Twain fully uses his great humor to deeply criticize and satirize the darkness of the society in Pudd'nhead Wilson.This paper mainly makes an exploration on Twain's anti-slavery theme and marvelous humor in the novel.
Long-Term Exclusive Zinc Monotherapy in Symptomatic Wilson Disease : Experience in 17 Patients
Linn, Francisca H. H.; Houwen, Roderick H. J.; van Hattum, Jan; van der Kleij, Stefan; van Erpecum, Karel J.
2009-01-01
Exclusive monotherapy with zinc in symptomatic Wilson disease is controversial. Seventeen symptomatic patients with Wilson disease were treated with zinc only. The mean age at diagnosis and start of treatment was 18 years (range 13-26) with approximately half presenting as adolescents. Presentation
Mathematical Derivation of Chiral Anomaly in Lattice Gauge Theory with Wilson's Action
Hattori, T G; Hattori, Tetsuya; Watanabe, Hiroshi
1998-01-01
Chiral U(1) anomaly is derived with mathematical rigor for a Euclidean fermion coupled to a smooth external U(1) gauge field on an even dimensional torus as a continuum limit of lattice regularized fermion field theory with the Wilson term in the action. The present work rigorously proves for the first time that the Wilson term correctly reproduces the chiral anomaly.
"Mens Sana in Corpore Sano": Human Values in Thomas Wilson's "The Arte of Rhetorique."
Luehring, Janet
In 1553 the work that is touted as the first complete book written in English on rhetoric was published, Thomas Wilson's "Arte of Rhetorique." It became so popular it enjoyed eight printings within its century. Wilson was not a person to translate and read just for knowledge; he believed that knowledge should be imparted to the general…
Calculation of the Perturbative Expansion of Wilson Operators on the Lattice
Liu, Da-Qing; Wu, Ji-Min; Chen, Ying
2001-11-01
We introduce an approach to expand gauge-invariant Wilson operators on the lattice. This approach is based on the non-Abelian-Stokes theorem and overcomes the disadvantages of the Luscher-Weisz method. It is also suitable for expanding any Wilson operator.
Calculation of the Perturbative Expansion of Wilson Operators on the Lattice
Institute of Scientific and Technical Information of China (English)
刘大庆; 吴济民; 陈莹
2001-01-01
We introduce an approach to expand gauge-invariant Wilson operators on the lattice. This approach is based on the non-Abelian-Stokes theorem and overcomes the disadvantages of the Luscher-Weisz method. It is also suitable for expanding any Wilson operator.
Construction and classification of novel BPS Wilson loops in quiver Chern–Simons-matter theories
Directory of Open Access Journals (Sweden)
Hao Ouyang
2016-09-01
Full Text Available In this paper we construct and classify novel Drukker–Trancanelli (DT type BPS Wilson loops along infinite straight lines and circles in N=2,3 quiver superconformal Chern–Simons-matter theories, Aharony–Bergman–Jafferis–Maldacena (ABJM theory, and N=4 orbifold ABJM theory. Generally we have four classes of Wilson loops, and all of them preserve the same supersymmetries as the BPS Gaiotto–Yin (GY type Wilson loops. There are several free complex parameters in the DT type BPS Wilson loops, and for two classes of Wilson loops in ABJM theory and N=4 orbifold ABJM theory there are supersymmetry enhancements at special values of the parameters. We check that the differences of the DT type and GY type Wilson loops are Q-exact with Q being some supercharges preserved by both the DT type and GY type Wilson loops. The results would be useful to calculate vacuum expectation values of the DT type Wilson loops in matrix models if they are still BPS quantum mechanically.
Construction and classification of novel BPS Wilson loops in quiver Chern-Simons-matter theories
Ouyang, Hao; Wu, Jun-Bao; Zhang, Jia-ju
2016-09-01
In this paper we construct and classify novel Drukker-Trancanelli (DT) type BPS Wilson loops along infinite straight lines and circles in N = 2 , 3 quiver superconformal Chern-Simons-matter theories, Aharony-Bergman-Jafferis-Maldacena (ABJM) theory, and N = 4 orbifold ABJM theory. Generally we have four classes of Wilson loops, and all of them preserve the same supersymmetries as the BPS Gaiotto-Yin (GY) type Wilson loops. There are several free complex parameters in the DT type BPS Wilson loops, and for two classes of Wilson loops in ABJM theory and N = 4 orbifold ABJM theory there are supersymmetry enhancements at special values of the parameters. We check that the differences of the DT type and GY type Wilson loops are Q-exact with Q being some supercharges preserved by both the DT type and GY type Wilson loops. The results would be useful to calculate vacuum expectation values of the DT type Wilson loops in matrix models if they are still BPS quantum mechanically.
Machine News and Volatility: The Dow Jones Industrial Average and the TRNA Sentiment Series
D.E. Allen (David); A.K. Singh (Abhay)
2014-01-01
markdownabstract__Abstract__ This paper features an analysis of the relationship between the volatility of the Dow Jones Industrial Average (DJIA) Index and a sentiment news series using daily data obtained from the Thomson Reuters News Analytics (TRNA) provided by SIRCA (The Securities Industry Re
Baron, Christopher; Hamlin, Christopher
2015-01-01
Between 1906 and 1909 the biologist Ronald Ross and the classicist W.H.S. Jones pioneered interdisciplinary research in biology and history in advancing the claim that malaria had been crucial in the decline of golden-age Greece (fourth century BCE). The idea had originated with Ross, winner of the Nobel Prize for demonstrating the importance of…
Käsitsi tegemise võlu / David Jones ; intervjueerinud Kai Lobjakas
Jones, David, 1953-
2010-01-01
10. Kohila keraamikasümpoosionil osalenud briti keraamik ja teoreetik David Jones endast, rakutehnikast, huvist põletamisega seonduvate teemade vastu, Kohila sümpoosioni raames tehtust, keraamika õpetamisest Inglismaal, käsitöö ja keraamika positsioonist praegu ja tulevikus jm.
PHYTOREMEDIATION OF DREDGED SEDIMENTS: A CASE STUDY AT THE JONES ISLAND CDF
The Jones Island Confined Disposal Facility (CDF) is a 44 acre in-lake area that receives dredged material from Milwaukee Harbor and the surrounding waterways. Some of those materials are contaminated with industrial waste and urban run-off. The CDF is nearing the end of its desi...
Widom line for the liquid-gas transition in Lennard-Jones system.
Brazhkin, V V; Fomin, Yu D; Lyapin, A G; Ryzhov, V N; Tsiok, E N
2011-12-08
The locus of extrema (ridges) for heat capacity, thermal expansion coefficient, compressibility, and density fluctuations for model particle systems with Lennard-Jones (LJ) potential in the supercritical region have been obtained. It was found that the ridges for different thermodynamic values virtually merge into a single Widom line at T Widom line for a liquid-gas transition.
Creative Imagination and Subjective Agency in Wynne-Jones' "The Maestro"
Cairns, Sue Ann
2009-01-01
The Canadian young adult novel "The Maestro" by Tim Wynne-Jones foregrounds the relationship between imagination and subjective agency. While Burl uses his imagination at the beginning to protect himself from his abusive father, his fantasies become dress rehearsals for small performances that allow him to try on new identities and exercise…
"Armastuse retsepti" tippkokk Zeta Jones ei oska muna keeta / Triin Tael
Tael, Triin
2007-01-01
Scott Hicksi romantiline komöödiafilm "Armastuse retsept" ("No Reservations"), mille peaosas Walesist pärit näitlejanna Catherine Zeta Jones. Näitlejanna muljeid oma rolliks ettevalmistustest, mille hulka käis ka praktika pärisrestoranis
Martínez-Roldan, Carmen M.
2013-01-01
This study illustrates the presence of Mock Spanish in some English-based picture books and the ways this usage misrepresents Latino people, language, and culture. The author conducted a critical content analysis of five Skippyjon Jones books. Her guiding question was, How is language used, particularly Spanish, in these English texts, and what…
Freezing and melting equations for the n-6 Lennard-Jones systems
Directory of Open Access Journals (Sweden)
Sergey A. Khrapak
2016-05-01
Full Text Available We generalize previous approach of Khrapak and Morfill [J. Chem. Phys. 134, 094108 (2011] to construct simple and sufficiently accurate freezing and melting equations for the conventional Lennard-Jones (LJ system to n-6 LJ systems, using the accurate results for the triple points of these systems published by Sousa et al. [J. Chem. Phys. 136, 174502 (2012].
Can the Lennard-Jones solid be expected to be fcc?
Waal, van de Benjamin W.
1991-01-01
The structure of the Lennard-Jones solid, obtained by molecular-dynamics simulation of crystallization in the supercooled liquid, may be fcc, although the hcp structure is energetically more favorable. This could derive from the cubic symmetry of the fcc lattice, allowing lattice defects that are no
Enhancing Undergraduates' Capabilities through Team-Based Competitions: The Edward Jones Challenge
Umble, Elisabeth J.; Umble, Michael; Artz, Kendall
2008-01-01
The Edward Jones Company recently initiated financial sponsorship of team-based competitions in six undergraduate business core classes at Baylor University. The challenges were chosen to take place in an introductory freshman business class, Managerial Accounting, Principles of Marketing, Corporate Finance, Operations Management, and Strategic…
Baron, Christopher; Hamlin, Christopher
2015-01-01
Between 1906 and 1909 the biologist Ronald Ross and the classicist W.H.S. Jones pioneered interdisciplinary research in biology and history in advancing the claim that malaria had been crucial in the decline of golden-age Greece (fourth century BCE). The idea had originated with Ross, winner of the Nobel Prize for demonstrating the importance of…
Thermodynamic Perturbation Theory for Solid-Liquid Phase Transition of Lennard-Jones Model
Institute of Scientific and Technical Information of China (English)
ZHOUShi-Qi; ZHANGXiao-Qi
2004-01-01
Both a free volume approach for Helmholtz free energy and a theoretically-based fitted formula for radial distribution function (rdf) of hard sphere solid are employed to describe the Helmholtz free energy of Lennard-Jones solid in the framework of the first order thermodynamic perturbation theory, which also is employed for the uniform Lennard Jones fluid. The dividing of the Lennard-Jones potential follows from the INCA prescription, but the specification of the equivalent hard sphere diameter is determined by a simple iteration procedure devised originally for liquid state, but extended to solid state in the present study. Two hundred shells are used in the rdf to get an accurate perturbation term.The present approach is very accurate for the description of excess Helmholtz free energy of LJ solid, but shows some deviation from the simulation for excess Helmholtz free energy of uniform LJ fluid when the reduced temperature kT/ε is higher then 5. The present approach is satisfactory for description of solid-liquid phase transition of the Lennard-Jones model.
Thermodynamic Perturbation Theory for Solid-Liquid Phase Transition of Lennard-Jones Model
Institute of Scientific and Technical Information of China (English)
ZHOU Shi-Qi; ZHANG Xiao-Qi
2004-01-01
Both a free volume approach for Helmholtz free energy and a theoretically-based fitted formula for radial distribution function (rdf) of hard sphere solid are employed to describe the Helmholtz free energy of Lennard-Jones solid in the framework of the first order thermodynamic perturbation theory, which also is employed for the uniform LennardJones fluid. The dividing of the Lennard-Jones potential follows from the WCA prescription, but the specification of the equivalent hard sphere diameter is determined by a simple iteration procedure devised originally for liquid state, but extended to solid state in the present study. Two hundred sheiks are used in the rdf to get an accurate perturbation term.The present approach is very accurate for the description of excess Helmholtz free energy of LJ solid, but shows some deviation from the simulation for excess Helmholtz free energy of uniform LJ fluid when the reduced temperature kT/ε is higher then 5. The present approach is satisfactory for description of solid-liquid phase transition of the Lennard-Jones model.
Fusion process of Lennard-Jones clusters: global minima and magic numbers formation
DEFF Research Database (Denmark)
Solov'yov, Ilia; Solov'yov, Andrey V.; Greiner, Walter
2004-01-01
We present a new theoretical framework for modeling the fusion process of Lennard–Jones (LJ) clusters. Starting from the initial tetrahedral cluster configuration, adding new atoms to the system and absorbing its energy at each step, we find cluster growing paths up to the cluster size of 150 atoms...
Käsitsi tegemise võlu / David Jones ; intervjueerinud Kai Lobjakas
Jones, David, 1953-
2010-01-01
10. Kohila keraamikasümpoosionil osalenud briti keraamik ja teoreetik David Jones endast, rakutehnikast, huvist põletamisega seonduvate teemade vastu, Kohila sümpoosioni raames tehtust, keraamika õpetamisest Inglismaal, käsitöö ja keraamika positsioonist praegu ja tulevikus jm.
Computer simulation study of gas–liquid nucleation in a Lennard-Jones system
Wolde, P.R. ten; Frenkel, D.
1998-01-01
We report a computer-simulation study of homogeneous gas–liquid nucleation in a Lennard-Jones system. Using umbrella sampling, we compute the free energy of a cluster as a function of its size. A thermodynamic integration scheme is employed to determine the height of the nucleation barrier as a func
Enhancing Undergraduates' Capabilities through Team-Based Competitions: The Edward Jones Challenge
Umble, Elisabeth J.; Umble, Michael; Artz, Kendall
2008-01-01
The Edward Jones Company recently initiated financial sponsorship of team-based competitions in six undergraduate business core classes at Baylor University. The challenges were chosen to take place in an introductory freshman business class, Managerial Accounting, Principles of Marketing, Corporate Finance, Operations Management, and Strategic…
Martínez-Roldan, Carmen M.
2013-01-01
This study illustrates the presence of Mock Spanish in some English-based picture books and the ways this usage misrepresents Latino people, language, and culture. The author conducted a critical content analysis of five Skippyjon Jones books. Her guiding question was, How is language used, particularly Spanish, in these English texts, and what…
Fusion process of Lennard-Jones clusters: global minima and magic numbers formation
DEFF Research Database (Denmark)
Solov'yov, Ilia; Solov'yov, Andrey V.; Greiner, Walter
2004-01-01
We present a new theoretical framework for modeling the fusion process of Lennard–Jones (LJ) clusters. Starting from the initial tetrahedral cluster configuration, adding new atoms to the system and absorbing its energy at each step, we find cluster growing paths up to the cluster size of 150 atoms...
"Armastuse retsepti" tippkokk Zeta Jones ei oska muna keeta / Triin Tael
Tael, Triin
2007-01-01
Scott Hicksi romantiline komöödiafilm "Armastuse retsept" ("No Reservations"), mille peaosas Walesist pärit näitlejanna Catherine Zeta Jones. Näitlejanna muljeid oma rolliks ettevalmistustest, mille hulka käis ka praktika pärisrestoranis
Aydinli, Musa; Harmanci, Ozgur; Ersoy, Osman; Iskit, Arzu T.; Ozcebe, Osman; Abbasoglu, Osman; Bayraktar, Yusuf
2006-01-01
We report two atypical cases of Wilson's disease. The first case is a 22-year-old male patient with a history of disease for 15 years and diagnosed as Wilson's disease upon investigations. Alpha-fetoprotein level was found elevated and computed tomography showed a 3.5-cm liver mass. Hepatocellular carcinoma was diagnosed. Radiofrequency ablation and liver transplantation were performed successfully. The second case is a 24-year-old female patient who presented with fulminant hepatitis. Urinary copper excretion and ceruloplasmin levels were suggestive of Wilson's disease. Despite chelation therapy, no improvement was observed. Plasma exchange therapy was performed for seven days. Her clinical status improved, and transplantation was no longer needed. To conclude, although hepatoma is rarely seen in Wilson's disease, patients should be examined regularly to diagnose it in a treatable stage. Removal of copper and toxic metabolites with plasma exchange therapy may be a way of treatment for fulminant hepatitis associated with Wilson's disease. PMID:17225847
Haemolytic anaemia as first manifestation of Wilson's disease: a report of two cases.
Santra, Gouranga; Paul, Rudrajit; Choudhury, Partha Sarathi; Ghosh, Sumit Kr; De, Dibyendu; Das, Shubhabrata
2014-10-01
Wilson's disease can have different manifestations like jaundice, cirrhosis of liver, extrapyramidal symptoms and dementia. Haemolytic anaemia may occur but it is commonly associated with florid manifestation of liver disease. Sometimes, liver cell necrosis can release huge free copper ions in blood, giving rise to oxidant damage to erythrocytes. Oxidative damage to cell membrane, haemoglobin and erythrocyte metabolism causes haemolytic crisis. In some cases, liver involvement is subclinical, but nonetheless, free copper is released from necrosed hepatocytes and causes oxidative damage to erythrocytes.We had two cases of Wilson's disease with initial presentation as severe haemolytic anaemia and no other clinical feature suggestive of Wilson's disease was present. In unclear cause of haemolytic anaemia, especially in adolescents or young adults, Wilson's disease should be considered. As Wilson disease is rare and its initial presentation with haemolytic anaemia is rarer, high level of suspicion is required to diagnose it.
The absolute voltage and the lead vector of Wilson's central terminal.
Miyamoto, N; Shimizu, Y; Nishiyama, G; Mashima, S; Okamoto, Y
1996-03-01
The absolute potential value of Wilson's central terminal was calculated at 2 msec intervals during a cardiac cycle in 60 clinical cases. Starting from the body surface potential data at 128 thoracic locations, the effect of immersion of the body into an infinite conductor on the surface potential was calculated to obtain values with reference to zero potential at infinity. The conductivity of the outside medium was then made to approach zero. Comparison of the result with the original map showed nearly a constant shift of the potential, corresponding to the voltage of Wilson's terminal. In addition, the cardiac vector was calculated as the first approximation of the cardiac electromotive force and the lead vector of Wilson's terminal was obtained in order that the scalar product of the cardiac vector and the lead vector approximated the observed voltage of Wilson's terminal. The results indicate that the voltage of the Wilson electrode depended on the surface voltage with a peak value near the maximal QRS force in most of the cases. The peak voltage of Wilson's terminal was either positive or negative, and was 0.15 mV in absolute value on average. Voltage variations of Wilson's terminal during a cardiac cycle were 0.20 mV as an average of all cases. The voltage of Wilson's terminal also depended on the direction of the equivalent cardiac vector. The lead vector of Wilson's terminal was found to be directed superiorly in most of the cases. The average magnitude of the lead vector of Wilson's terminal was 0.097 omega/cm, which corresponded to about 1/4 of that of lead I.
Directory of Open Access Journals (Sweden)
Mayara Paim Patel
2014-06-01
Full Text Available OBJECTIVE: The aim of this study was to cephalometrically assess the skeletal and dentoalveolar effects of Class II malocclusion treatment performed with the Jones Jig appliance followed by fixed appliances. METHODS: The sample comprised 25 patients with Class II malocclusion treated with the Jones Jig appliance followed by fixed appliances, at a mean initial age of 12.90 years old. The mean time of the entire orthodontic treatment was 3.89 years. The distalization phase lasted for 0.85 years, after which the fixed appliance was used for 3.04 years. Cephalograms were used at initial (T1, post-distalization (T2 and final phases of treatment (T3. For intragroup comparison of the three phases evaluated, dependent ANOVA and Tukey tests were used. RESULTS: Jones Jig appliance did not interfere in the maxillary and mandibular component and did not change maxillomandibular relationship. Jones Jig appliance promoted distalization of first molars with anchorage loss, mesialization and significant extrusion of first and second premolars, as well as a significant increase in anterior face height at the end of treatment. The majority of adverse effects that occur during intraoral distalization are subsequently corrected during corrective mechanics. Buccal inclination and protrusion of mandibular incisors were identified. By the end of treatment, correction of overjet and overbite was observed. CONCLUSIONS: Jones Jig appliance promoted distalization of first molars with anchorage loss represented by significant mesial movement and extrusion of first and second premolars, in addition to a significant increase in anterior face height.
van Meer, Suzanne; de Man, Robert A.; van den Berg, Aad P.; Houwen, Roderick H. J.; Linn, Francisca H. H.; van Oijen, Martijn G. H.; Siersema, Peter D.; van Erpecum, Karel J.
2015-01-01
Background and AimsData on risk of hepatocellular carcinoma (HCC) in patients with Wilson disease are scarce. We determine HCC risk in a well-defined cohort of Wilson patients. MethodsAll patients with a confirmed diagnosis of Wilson disease (Leipzig score4) in three Dutch university referral hospit
Meer, S. Winters-Van Der; Man, R.A. de; Berg, A.P. van den; Houwen, R.H.; Linn, F.H.; Oijen, M.G. van; Siersema, P.D.; Erpecum, K.J. van
2015-01-01
BACKGROUND AND AIMS: Data on risk of hepatocellular carcinoma (HCC) in patients with Wilson disease are scarce. We determine HCC risk in a well-defined cohort of Wilson patients. METHODS: All patients with a confirmed diagnosis of Wilson disease (Leipzig score >/= 4) in three Dutch university ref
Study of Cullum's and Willoughby's Lanczos method for Wilson fermions
Kalkreuter, T
1995-01-01
The Lanczos method of Cullum and Willoughby is studied for euclidean Wilson fermions in quenched and unquenched SU(2) gauge fields on lattices of volume ranging from 4^4 to 16^4. The method is reliable even on larger lattices, but its cost for the computation of a given fraction of the spectrum grows (approximately) with the square of the lattice volume. We investigate the convergence behaviour and show that it is closely linked with the local spectral density. Complete spectra are determined on lattices up to 8^3 \\cdot 12. For configurations where all eigenvalues are computed, we give numerical values for the fermionic determinants and results for spectral densities. Determinants are also given for staggered fermions whose quenched and unquenched spectra were studied in a previous publication.
Study of Cullum's and Willoughby's Lanczos method for Wilson fermions
Kalkreuter, T.
1996-05-01
The Lanczos method of Cullum and Willoughby is studied for euclidean Wilson fermions in quenched and unquenched SU(2) gauge fields on lattices of volume ranging from $4^4$ to $16^4$. The method is reliable even on larger lattices, but its cost for the computation of a given fraction of the spectrum grows (approximately) with the square of the lattice volume. We investigate the convergence behaviour and show that it is closely linked with the local spectral density. Complete spectra are determined on lattices up to $8^3 \\cdot 12$. For configurations where all eigenvalues are computed, we give numerical values for the fermionic determinants and results for spectral densities. Determinants are also given for staggered fermions whose quenched and unquenched spectra were studied in a previous publication.
Phenotype-genotype correlations in patients with Wilson's disease.
Ferenci, Peter
2014-05-01
There is considerable phenotypic variation in Wilson's disease (WD). Some patients present with hepatic disease during the first decade of life and some with neurological degeneration in adolescence or adult life, with or without overt liver disease. Although the absence of neurologic disease in patients with liver disease in childhood or adolescence can be explained by the limited time exposure of the central nervous system to copper toxicity, it is surprising that late-onset neurologic WD can occur without any evidence of liver involvement. This huge variability in the clinical presentation of WD in general reflects our limited knowledge on the natural history of WD. Genetic association studies require the phenotype to be defined as accurately as possible.
Wilson's disease: a comprehensive review of the molecular mechanisms.
Wu, Fei; Wang, Jing; Pu, Chunwen; Qiao, Liang; Jiang, Chunmeng
2015-01-01
Wilson's disease (WD), also known as hepatolenticular degeneration, is an autosomal recessive inherited disorder resulting from abnormal copper metabolism. Reduced copper excretion causes an excessive deposition of the copper in many organs such as the liver, central nervous system (CNS), cornea, kidney, joints, and cardiac muscle where the physiological functions of the affected organs are impaired. The underlying molecular mechanisms for WD have been extensively studied. It is now believed that a defect in P-type adenosine triphosphatase (ATP7B), the gene encoding the copper transporting P-type ATPase, is responsible for hepatic copper accumulation. Deposited copper in the liver produces toxic effects via modulating several molecular pathways. WD can be a lethal disease if left untreated. A better understanding of the molecular mechanisms causing the aberrant copper deposition and organ damage is the key to developing effective management approaches.
Successful treatment of fulminant Wilson's disease without liver transplantation.
Motobayashi, Mitsuo; Fukuyama, Tetsuhiro; Nakayama, Yoshiko; Sano, Kenji; Noda, Shunsuke; Hidaka, Yoshihiko; Amano, Yoshiro; Ikeda, Shu-Ichi; Koike, Kenichi; Inaba, Yuji
2014-06-01
Fulminant Wilson's disease (WD) is life-threatening. The revised WD prognostic index (RWPI) has been used to predict the severity of the disease, with a score ≥11 indicating fatal outcome without liver transplantation (LTx). We here report the case of a 10-year-old female patient with fulminant WD (RWPI, 16) who recovered fully after plasma exchange and continuous hemodiafiltration, followed by treatment with copper chelate agents. To the best of our knowledge, there have been five fulminant WD patients with RWPI ≥ 11 including the present patient, in whom LTx was not done. Based on the therapeutic modalities in these five cases, non-surgical treatment (blood purification and copper chelate agents) may be able to avoid LTx in fulminant WD even with very high RWPI, although preparation for LTx is necessary.
Modifying factors and phenotypic diversity in Wilson's disease.
Lutsenko, Svetlana
2014-05-01
Wilson's disease (WD) is a human disorder of copper homeostasis caused by mutations in the copper-transporting ATPase ATP7B. WD is characterized by copper accumulation, predominantly in the liver and brain, hepatic pathology, and wide differences between patients in the age of onset and the spectrum of symptoms. Several factors contribute to the phenotypic variability of WD. The WD-causing mutations produce a wide range of changes in stability, activity, intracellular localization, and trafficking of ATP7B; the nonpathogenic genetic polymorphisms may contribute to the phenotype. In Atp7b(-/-) mice, a mouse model of WD, an abnormal intracellular distribution of copper in the liver triggers distinct changes in the transcriptome; these mRNA profiles might be used to more specifically define disease progression. The major effect of accumulating copper on lipid metabolism and especially cholesterol homeostasis in mice and humans suggests the importance of fat and cholesterol metabolism as modifying factors in WD.
Single spin asymmetries from a single Wilson loop
Boer, Daniël; Mulders, Piet; Zhou, Jian
2015-01-01
We study the leading-power gluon transverse momentum dependent distributions (TMDs) of relevance to asymmetries in the scattering off transversely polarized hadrons. Next-to-leading-order perturbative calculations of these TMDs show that at large transverse momentum they have common dynamical origins, but that in the limit of small longitudinal momentum fraction $x$ only one origin remains. We find that in this limit only the $C$-odd or dipole-type gluon TMDs survive and become identical to each other. At small $x$ they are all given by the expectation value of a single Wilson loop inside the transversely polarized hadron, the so-called spin-dependent odderon. This universal origin of transverse spin asymmetries at small $x$ is of importance to current and future experimental studies, paving the way to a better understanding of the role of gluons in the three-dimensional structure of spin-polarized protons.
Kenneth G. Wilson: Renormalized After-Dinner Anecdotes
Ginsparg, Paul
2014-01-01
This is the transcript of the after-dinner talk I gave at the close of the 16 Nov 2013 symposium "Celebrating the Science of Kenneth Geddes Wilson" [1] at Cornell University (see Fig. 1 for the poster). The video of my talk is on-line [2], and this transcript is more or less verbatim, with the slides used included as figures. I've also annotated it with a few clarifying footnotes, and provided references to the source materials where available. The talk itself pulls together anecdotes from various points in his career, discusses my own graduate student experiences with him, and finishes with some video excerpts from an interview he did in 2010.
FUNCTIONAL ANALYSIS AND GENOTYPE-PHENOTYPE CORRELATIONS IN WILSON DISEASE
Directory of Open Access Journals (Sweden)
Elena Scvortova
2013-10-01
Full Text Available Abstract: Knowledge of how mutations other than p.H1069Q translate into the basic defect in Wilson disease (WD is scarce due to the low incidence of homozygous index cases. A total of 12 homozygous mutations of ATP7B, were examined for their functional activity. Transfected Chinese hamster ovary cells (CHO-K1 exposed to elevated copper levels was used as a model for predicting the severity of different WD mutations. The results of this research have direct implications for WD diagnosis. Our data strongly confirms that phenotypic presentation of the patients is related to the ATP7B mutation, providing evidence for genotype - phenotype correlations and can explain in part the variable clinical features observed in patients with WD. The results we have provided help to highlight the information still needed for understanding the function and malfunction of ATP7B and its role in the disease.
Dental management of a patient with Wilson's disease.
da Silva Santos, Paulo Sergio; Fernandes, Karin Sa; Fraige, Alexandre; Gallottini, Marina
2015-01-01
Wilson's disease (WD) is an autosomal recessive genetic disease, characterized by the accumulation of copper in the body--primarily in the brain and liver--due to defective biliary copper excretion by hepatocytes. WD may manifest clinically as liver disease, neurologic symptoms, and Kayser-Fleischer corneal rings. This article presents a case involving a 43-year-old man who had WD prior to liver transplantation. Oral examination revealed petechiae in the oral mucosa, poor oral hygiene, periodontal disease, missing teeth, and several carious teeth. Patients with WD may present systemic changes that affect dental care. Dental treatment prior to liver transplantation is recommended to eliminate the oral foci of infection and control oral disease.
Multimodal evoked potential abnormalities in patients with Wilson's disease
Directory of Open Access Journals (Sweden)
Ilić Tihomir V.
2005-01-01
Full Text Available The aim of this study was to investigate the involvement of the following functional systems: somatosensory evoked potentials (SSEP, visual evoked potentials (VEP, and event related potentials (ERP, in twenty patients with Wilson's disease (WD. VEP and SSEP abnormalities were discovered in S patients respectively (40%, whereas ERP were either absent or, in the case of 10 patients (50%, had significantly prolonged P-300 latencies. Taken together, at least one evoked potential abnormality was discovered in 17 patients (85%]. Only in 3 patients (15%, involving either the isolated hepatic type of disease or short illness duration of the neurological type, were normal evoked potential findings observed. Our findings suggest the usefulness of multimodal evoked potential abnormalities in the evaluation of subclinical manifestations in patients with WD.
Wilson's disease: A review of what we have learned.
Rodriguez-Castro, Kryssia Isabel; Hevia-Urrutia, Francisco Javier; Sturniolo, Giacomo Carlo
2015-12-18
Wilson's disease (WD), which results from the defective ATP7B protein product, is characterized by impaired copper metabolism and its clinical consequences vary from an asymptomatic state to fulminant hepatic failure, chronic liver disease with or without cirrhosis, neurological, and psychiatric manifestations. A high grade of suspicion is warranted to not miss cases of WD, especially less florid cases with only mild elevation of transaminases, or isolated neuropsychiatric involvement. Screening in first and second relatives of index cases is mandatory, and treatment must commence upon establishment of diagnosis. Treatment strategies include chelators such as D-penicillamine and trientine, while zinc salts act as inductors of methallothioneins, which favor a negative copper balance and a reduction of free plasmatic copper. As an orphan disease, research is lacking in this field, especially regarding therapeutic strategies which are associated with better patient compliance and which could eventually also reverse established injury.
QCD thermodynamics with continuum extrapolated Wilson fermions II
Borsanyi, Szabolcs; Fodor, Zoltan; Holbling, Christian; Katz, Sandor D; Krieg, Stefan; Nogradi, Daniel; Szabo, Kalman K; Toth, Balint C; Trombitas, Norbert
2015-01-01
We continue our investigation of 2+1 flavor QCD thermodynamics using dynamical Wilson fermions in the fixed scale approach. Two additional pion masses, approximately 440 MeV and 285 MeV, are added to our previous work at 545 MeV. The simulations were performed at 3 or 4 lattice spacings at each pion mass. The renormalized chiral condensate, strange quark number susceptibility and Polyakov loop is obtained as a function of the temperature and we observe a decrease in the light chiral pseudo-critical temperature as the pion mass is lowered while the pseudo-critical temperature associated with the strange quark number susceptibility or the Polyakov loop is only mildly sensitive to the pion mass. These findings are in agreement with previous continuum results obtained in the staggered formulation.
Encephalopathy in Wilson disease: copper toxicity or liver failure?
Ferenci, Peter; Litwin, Tomasz; Seniow, Joanna; Czlonkowska, Anna
2015-03-01
Hepatic encephalopathy (HE) is a complex syndrome of neurological and psychiatric signs and symptoms that is caused by portosystemic venous shunting with or without liver disease irrespective of its etiology. The most common presentation of Wilson disease (WD) is liver disease and is frequently associated with a wide spectrum of neurological and psychiatric symptoms. The genetic defect in WD leads to copper accumulation in the liver and later in other organs including the brain. In a patient presenting with Wilsonian cirrhosis neuropsychiatric symptoms may be caused either by the metabolic consequences of liver failure or by copper toxicity. Thus, in clinical practice a precise diagnosis is a great challenge. Contrary to HE in neurological WD consciousness, is very rarely disturbed and pyramidal signs, myoclonus dominate. Asterixis and many other clinical symptoms may be present in both disease conditions and are quite similar. However details of neurological assessment as well as additional examinations could help in differential diagnosis.
Microbial peptide de-coppers mitochondria: implications for Wilson disease.
Kaler, Stephen G
2016-07-01
The severe liver pathology of untreated Wilson disease (WD) is associated with massive copper overload caused by mutations in a liver-specific copper-transporting ATPase, ATP7B. While early, presymptomatic detection and chelation with conventional copper-binding molecules enables effective and life-saving treatment, liver transplantation is the sole option currently available for those with advanced disease. In this issue of the JCI, Lichtmannegger, Leitzinger, and colleagues delineate the therapeutic effect of methanobactin (MB), a potent bacterial copper-binding protein, at three late stages of disease in a WD rat model. Their results suggest that a formal clinical trial of MB in human subjects with severe hepatic pathology caused by WD would be rational.
Ginsparg-Wilson Pions Scattering on a Staggered Sea
Chen, J W; De van Water, R S; Walker-Loud, A; Chen, Jiunn-Wei; Connell, Donal O'; Water, Ruth S. Van de; Walker-Loud, Andre
2006-01-01
In this article, we calculate isospin 2 (I=2) pion-pion scattering in chiral perturbation theory for a partially quenched, mixed action theory with Ginsparg-Wilson valence quarks and staggered sea quarks. We determine the scattering length at threshold for both 2 sea quarks and 2+1 sea quarks in the isospin limit. The scattering length, expressed in terms of the pion mass and the decay constant measured on the lattice, has no contributions from mixed valence-sea mesons. Thus, it does not depend upon the parameter, C_Mix, that appears in the chiral Lagrangian of the mixed theory. This result holds for both 2 and 2+1 flavors of sea quarks. Finally, we take the continuum limit of our mixed action results and give expressions for the scattering length in continuum 2 and 2+1 flavor partially quenched chiral perturbation theory.
Higher Rank ABJM Wilson Loops from Matrix Models
Cookmeyer, Jonathan; Liu, James; Zayas, Leopoldo
2017-01-01
We compute the expectation values of 1/6 supersymmetric Wilson Loops in ABJM theory in higher rank representations. Using standard matrix model techniques, we calculate the expectation value in the rank m fully symmetric and fully antisymmetric representation where m is scaled with N. To leading order, we find agreement with the classical action of D6 and D2 branes in AdS4 ×CP3 respectively. Further, we compute the first subleading order term, which, on the AdS side, makes a prediction for the one-loop effective action of the corresponding D6 and D2 branes. Supported by the National Science Foundation under Grant No. PHY 1559988 and the US Department of Energy under Grant No. DE-SC0007859.
Imaginary parts and discontinuities of Wilson line correlators
Laenen, Eric; Rietkerk, Robbert
2014-01-01
We introduce a notion of position-space cuts of eikonal diagrams, the set of diagrams appearing in the perturbative expansion of the correlator of a set of straight semi-infinite Wilson lines. The cuts are applied directly to the position-space representation of any such diagram and compute its imaginary part to the leading order in the dimensional regulator. Our cutting prescription thus defines a position-space analog of the standard momentum-space Cutkosky rules. Unlike momentum-space cuts which put internal lines on shell, position-space cuts constrain a number of the gauge bosons exchanged between the energetic partons to be lightlike, leading to a vanishing and a non-vanishing imaginary part for space- and time-like kinematics, respectively.
Gravity duals of half-BPS Wilson loops
Energy Technology Data Exchange (ETDEWEB)
D' Hoker, Eric; Estes, John; Gutperle, Michael [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States)
2007-06-15
We explicitly construct the fully back-reacted half-BPS solutions in Type IIB supergravity which are dual to Wilson loops with 16 supersymmetries in N = 4 super Yang-Mills. In a first part, we use the methods of a companion paper to derive the exact general solution of the half-BPS equations on the space AdS{sub 2} x S{sup 2} x S{sup 4} x {sigma}, with isometry group SO(2, 1) x SO(3) x SO(5) in terms of two locally harmonic functions on a Riemann surface {sigma} with boundary. These solutions, generally, have varying dilaton and axion, and non-vanishing 3-form fluxes. In a second part, we impose regularity and topology conditions. These non-singular solutions may be parametrized by a genus g {>=} 0 hyperelliptic surface {sigma}, all of whose branch points lie on the real line. Each genus g solution has only a single asymptotic AdS{sub 5} x S{sup 5} region, but exhibits g homology 3-spheres, and an extra g homology 5-spheres, carrying respectively RR 3-form and RR 5-form charges. For genus 0, we recover AdS{sub 5} x S{sup 5} with 3 free parameters, while for genus g {>=} 1, the solution has 2g+5 free parameters. The genus 1 case is studied in detail. Numerical analysis is used to show that the solutions are regular throughout the g = 1 parameter space. Collapse of a branch cut on {sigma} subtending either a homology 3-sphere or a homology 5-sphere is non-singular and yields the genus g-1 solution. This behavior is precisely expected of a proper dual to a Wilson loop in gauge theory.
Immunoglobulin M Nephropathy in a Patient with Wilson's Disease.
Ul Abideen, Zain; Sajjad, Zoya; Haroon Khan, Asna; Mamoon, Nadira; Bilal, Muhammad; Mujtaba Quadri, Khaja Hameeduddin
2016-12-13
Immunoglobulin M nephropathy (IgMN) is characterized by the deposition of immunoglobulin M in a dominant distribution in the renal glomeruli. Primary immunoglobulin M nephropathy is diagnosed after consistent light microscopy (LM), immunofluorescence (IF), electron microscopy (EM) results, and exclusion of known systemic disorders causing immunoglobulin M deposition in the glomeruli. The secondary disease has been reported with a few conditions though it has never been reported with any primary disease of the liver. We report the case of an adolescent male patient who presented with nausea, vomiting, diarrhea, and worsening anasarca. He was found to have nephrotic-range proteinuria that did not respond to conventional corticosteroid treatment. He was subjected to a renal biopsy which revealed a diagnosis of immunoglobulin M nephropathy. His liver function tests were deranged and an ultrasound scan of the abdomen revealed a coarse irregular liver. Workup revealed elevated urine copper excretion and a low ceruloplasmin level. He was diagnosed as a case of Wilson's disease and started on penicillamine and pyridoxine. He was also started on intravenous cyclophosphamide for the corticosteroid-resistant nephrotic syndrome to which he responded remarkably well. His edema settled, proteinuria resolved, and liver functions normalized. Currently, he is in remission and enjoying good health. To the best of our knowledge, we report the first known association between IgM nephropathy and Wilson's disease. It is presently not clear if causation can necessarily be established. This may be the result of defective IgM clearance by the liver or an altered metabolism of the antibody or immune complexes, as with hepatic-associated immunoglobulin M (IgM) nephropathy. Further studies are needed to elucidate the exact mechanism of this disease.
Currently Clinical Views on Genetics of Wilson's Disease
Institute of Scientific and Technical Information of China (English)
Chen Chen; Bo Shen; Jia-Jia Xiao; Rong Wu; Sarah Jane Duff Canning; Xiao-Ping Wang
2015-01-01
Objective:The objective of this study was to review the research on clinical genetics of Wilson's disease (WD).Data Sources:We searched documents from PubMed and Wanfang databases both in English and Chinese up to 2014 using the keywords WD in combination with genetic,ATP7B gene,gene mutation,genotype,phenotype.Study Selection:Publications about the ATP7B gene and protein function associated with clinical features were selected.Results:Wilson's disease,also named hepatolenticular degeneration,is an autosomal recessive genetic disorder characterized by abnormal copper metabolism caused by mutations to the copper-transporting gene A TP7B.Decreased biliary copper excretion and reduced incorporation of copper into apoceruloplasmin caused by defunctionalization of ATP7B protein lead to accumulation of copper in many tissues and organs,including liver,brain,and cornea,finally resulting in liver disease and extrapyramidal symptoms.It is the most common genetic neurological disorder in the onset of adolescents,second to muscular dystrophy in China.Early diagnosis and medical therapy are of great significance for improving the prognosis of WD patients.However,diagnosis of this disease is usually difficult because of its complicated phenotypes.In the last 10 years,an increasing number of clinical studies have used molecular genetics techniques.Improved diagnosis and prediction of the progression of this disease at the molecular level will aid in the development of more individualized and effective interventions,which is a key to transition from molecular genetic research to the clinical study.Conclusions:Clinical genetics studies are necessary to understand the mechanism underlying WD at the molecular level from the genotype to the phenotype.Clinical genetics research benefits newly emerging medical treatments including stem cell transplantation and gene therapy for WD patients.
Directory of Open Access Journals (Sweden)
Monfort J.-P.
2006-11-01
Full Text Available La volabilité relative ait; =(yilxil(Y;lxi des constituants d'un mélange binaire a été mesurée à partir d'un nouveau dispositif expérimental, on reporte les données d'équilibre liquide-vapeur obtenues à 45'C de plusieurs binaires : toluène-acétoni-trile, benzène-acétonitrile et benzène-n-heptane. En ajustant à l'équation de Wilson les données expérimentales de «i/; de ces constituants ainsi que des volatilités relatives des constituants des mélanges d'hydrocarbures-alcools, obtenues dans un précédent travail, on calcule les paramètres énergétiques. La prédiction des points de bulle de mélanges binaires et ternaires obtenue à partir de ces paramètres est satisfaisante. La méthode expérimentale ainsi proposée convient particulièrement pour la sélection des solvant extractifs utilisés dans la distillation extractive. From a new expérimental method, relative volatilities aiti = (yilxil(yilxi for a binary mixture are obtained; vapor-liquid equilibrium data are presented for several systems, i.e. toluene-acétonitrile, benzene-acétonitrile and benzene-n-heptane at 45°C. The two adjustable energyparameters of thé Wilson équation, are obtained by adopting thé «,/j data for these binary mixtures and for alcohol-hydrocarbon mixtures previously studied. Theresults obtained in predicting bubble-pressure data for binary and ternary mixtures are consistent with experimental data.
Ouyang, Hao; Zhang, Jia-ju
2015-01-01
We show that generic three-dimensional $\\mathcal N=2$ quiver Chern-Simons-matter theories admit Bogomol'nyi-Prasad-Sommerfield (BPS) Drukker-Trancanelli (DT) type Wilson loops. In Aharnoy-Bergman-Jafferis-Maldacena theory, we find that the generic BPS DT type Wilson loops preserve the same number of supersymmetries as Gaiotto-Yin type Wilson loops. There are several free parameters for the generic BPS DT type Wilson loops in the construction, and supersymmetry enhancement for Wilson loops only happens for special values of the parameters.
Effective lattice action for the configurations smeared by the Wilson flow
Kagimura, Aya; Yamamura, Ryo
2015-01-01
We investigate a trajectory for the Wilson flow in the theory space. For this purpose, we determine the coefficient of the plaquette and rectangular terms in the action for the configurations defined by the solution of the Wilson flow. The demon method regarded as one of the inverse Monte Carlo methods is used for the determination of them. Starting from the conventional Wilson plaquette action of quenched QCD, we find that the coefficient of the plaquette grows while that of the rectangular tends to negative with the development of the flow as the known improved actions. We also find that the trajectory forms a straight line in the two-coupling theory space.
1/4 BPS Wilson Loop in beta-deformed Theories
Chu, Chong-Sun
2007-01-01
We consider general BPS Wilson loop operators in the N=1 beta-deformed supersymmetric Yang-Mills theory and derive the boundary condition satisfied by the dual string worldsheet. The boundary condition is found to be deformed and is characterized by the vielbein of the deformed supergravity metric. We also construct the string dual configuration for the 1/4 BPS Wilson loop operators. The string lies on a deformed three-sphere instead of a two-sphere as in the undeformed case. We compute the expectation value of the Wilson loop operator using the AdS/CFT correspondence and find that it is independent of the deformation.
Generalized Loop Space and Evolution of the Light-Like Wilson Loops
Cherednikov, I O
2014-01-01
Equations of motion for the light-like QCD Wilson loops are studied in the generalized loop space (GLS) setting. To this end, the classically conformal-invariant non-local variations of the cusped Wilson exponentials lying (partially) on the light-cone are formulated in terms of the Fr\\'echet derivative. The rapidity and renormalization-group behaviour of the gauge-invariant quantum correlation functions (in particular, the three-dimensional parton densities) are demonstrated to be connected to certain geometrical properties of the Wilson loops defined in the GLS.
Kong, H L; Yap, I L; Kueh, Y K
1996-12-01
Haemolysis is an uncommon first manifestation of Wilson's disease. We describe a young woman who presented with episodic haemolysis and abnormal liver functions; the diagnosis of Wilson's disease was not made until nine months later. She responded well to a combination of penicillamine and zinc. This report underscores the importance of considering Wilson's disease as a cause in a patient with haemolysis of uncertain aetiology, since the disease can be successfully treated in the early stages. the mechanism of oxidative damage to erythrocytes by the excessive copper and the present role of zinc therapy are also discussed.
Is the third coefficient of the Jones knot polynomial a quantum state of gravity?
Griego, J R
1996-01-01
Some time ago it was conjectured that the coefficients of an expansion of the Jones polynomial in terms of the cosmological constant could provide an infinite string of knot invariants that are solutions of the vacuum Hamiltonian constraint of quantum gravity in the loop representation. Here we discuss the status of this conjecture at third order in the cosmological constant. The calculation is performed in the extended loop representation, a generalization of the loop representation. It is shown that the the Hamiltonian does not annihilate the third coefficient of the Jones polynomal (J_3) for general extended loops. For ordinary loops the result acquires an interesting geometrical meaning and new possibilities appear for J_3 to represent a quantum state of gravity.
Institute of Scientific and Technical Information of China (English)
SUN Zong-Li; KANG Yan-Shuang
2011-01-01
Classical density functional theory is used to study the associating Lennard Jones fluids in contact with spherical hard wall of different curvature radii. The interfacial properties including contact density and fluid-solid interfacial tension are investigated. The influences of associating energy, curvature of hard wall and the bulk density of Huids on these properties are analyzed in detail. The results may provide helpful clues to understand the interfacial properties of other complex fluids.%@@ Classical density functional theory is used to study the associating Lennard Jones fluids in contact with spherical hard wall of different curvature radii.The interfacial properties including contact density and fluid-solid intcrfacial tension are investigated.The influences of associating energy, curvature of hard wall and the hulk density of fluids on these properties are analyzed in detail.The results may provide helpful clues to understand the interfacial properties of other complex fluids.
Long range correction for multi-site Lennard-Jones models and planar interfaces
Werth, Stephan; Horsch, Martin; Vrabec, Jadran; Hasse, Hans
2015-01-01
A slab based long range correction approach for multi-site Lennard-Jones models is presented for systems with a planar film geometry that is based on the work by Janecek, J. Phys. Chem. B 110: 6264 (2006). It is efficient because it relies on a center-of-mass cutoff scheme and scales in terms of numerics almost perfectly with the molecule number. For validation, a series of simulations with the two-center Lennard-Jones model fluid, carbon dioxide and cyclohexane is carried out. The results of the present approach, a site-based long range correction and simulations without any long range correction are compared with respect to the saturated liquid density and the surface tension. The present simulation results exhibit only a weak dependence on the cutoff radius, indicating a high accuracy of the implemented long range correction.
Volatility Transmission between Dow Jones Stock Index and Emerging Bond Index
Directory of Open Access Journals (Sweden)
Amir Saadaoui
2016-04-01
Full Text Available In this paper, we use a bivariate GARCH model to estimate simultaneously of the mean and the conditional variance between the Dow Jones stock index and some emerging bond indices. We used the DCC-GARCH model to graphically demonstrate the peaks of the volatility transmission. We examined this transmission using daily returns between July, 30, 2009 and January, 18, 2011 extracted from Datastream. Our results demonstrate that there is a significant transmission of shocks and volatility between the Dow Jones stock index and bond indices of the emerging countries. The results also confirm the idea that the crisis was transmitted from the United States to the emerging countries due to foreign investment made in these countries.