Macdonald polynomials from Sklyanin algebras: A conceptual basis for the p-adics-quantum group connection

International Nuclear Information System (INIS)

Freund, P.G.O.

1992-01-01

We establish a previously conjectured connection between p-adics and quantum groups. We find in Sklyanin's two parameter elliptic quantum algebra and its generalizations, the conceptual basis for the Macdonald polynomials, which 'interpolate' between the zonal spherical functions of related real and p-adic symmetric spaces. The elliptic quantum algebras underlie the Z n -Baxter models. We show that in the n→∞ limit, the Jost function for the scattering of first level excitations in the Z n -Baxter model coincides with the Harish-Chandra-like c-function constructed from the Macdonald polynomials associated to the root system A 1 . The partition function of the Z 2 -Baxter model itself is also expressed in terms of this Macdonald-Harish-Chandra c-function albeit in a less simple way. We relate the two parameters q and t of the Macdonald polynomials to the anisotropy and modular parameters of the Baxter model. In particular the p-acid 'regimes' in the Macdonald polynomials correspond to a discrete sequence of XXZ models. We also discuss the possibility of 'q-deforming' Euler products. (orig.)

Life after Macdonald

International Nuclear Information System (INIS)

1997-01-01

This volume contains the edited summaries of discussions that occurred at the 8th annual meeting of the Canadian Independent Power Conference and Trade Show. The central theme of the conference was the recently published Macdonald Report, recommending unbundling of Ontario Hydro, and opening up the Ontario electric power market to competition. A variety of issues were addressed, among them the role of regulation in the new environment, experience in open markets, comments from the renewable energy industry, the environmental and economic benefits of sustainable development, municipal opportunities, rates for the competitive market and customer experiences and expectations. Biographical notes of the discussants, and a list of conference attendees were also included

A New Generalisation of Macdonald Polynomials

Science.gov (United States)

Garbali, Alexandr; de Gier, Jan; Wheeler, Michael

2017-06-01

We introduce a new family of symmetric multivariate polynomials, whose coefficients are meromorphic functions of two parameters ( q, t) and polynomial in a further two parameters ( u, v). We evaluate these polynomials explicitly as a matrix product. At u = v = 0 they reduce to Macdonald polynomials, while at q = 0, u = v = s they recover a family of inhomogeneous symmetric functions originally introduced by Borodin.

A Summation Formula for Macdonald Polynomials

Science.gov (United States)

de Gier, Jan; Wheeler, Michael

2016-03-01

We derive an explicit sum formula for symmetric Macdonald polynomials. Our expression contains multiple sums over the symmetric group and uses the action of Hecke generators on the ring of polynomials. In the special cases {t = 1} and {q = 0}, we recover known expressions for the monomial symmetric and Hall-Littlewood polynomials, respectively. Other specializations of our formula give new expressions for the Jack and q-Whittaker polynomials.

An algebraic approach to the non-symmetric Macdonald polynomial

International Nuclear Information System (INIS)

Nishino, Akinori; Ujino, Hideaki; Wadati, Miki

1999-01-01

In terms of the raising and lowering operators, we algebraically construct the non-symmetric Macdonald polynomials which are simultaneous eigenfunctions of the commuting Cherednik operators. We also calculate Cherednik's scalar product of them

Generalized Jack and Macdonald polynomials arising from AGT conjecture

Science.gov (United States)

Ohkubo, Y.

2017-01-01

We investigate the existence and the orthogonality of the generalized Jack symmetric functions which play an important role in the AGT relations. We show their orthogonality by deforming them to the generalized Macdonald symmetric functions.

Evaluation of the MacDonald scabbler for highway use.

Science.gov (United States)

1975-01-01

The MacDonald Scabbler is a small, hand held machine suitable for use in cleaning and roughening concrete surfaces, It weighs 308 pounds (140 kg), has 11 cutting heads, and, as a power source, requires a compressor capable of delivering 365 cubic foo...

A Substantiation of Macdonald's Models in Science Curriculum Development.

Science.gov (United States)

Searles, W. E.

1982-01-01

A history and analysis of science curriculum development is presented. Factors which influence the selection and organization of content in a science curriculum are discussed, including Macdonald's curriculum development models, propositions for curriculum development, and changes made in science curricula during the last century. (CJ)

Not the Sum of Its Parts: A Critical Review of the MacDonald Triad.

Science.gov (United States)

Parfitt, Charlotte Hannah; Alleyne, Emma

2018-01-01

The MacDonald triad posits that animal cruelty, fire setting, and bed wetting in childhood is indicative of later aggressive and violent behavior in adults. Researchers refer to this phenomenon as a precursor to later antisocial behaviors including serial and sexual murder; while practitioners cite the triad in clinical formulations and risk assessments. However, there is yet to be a critical review and consolidation of the literature that establishes whether there is empirical support. This article explores the validity of the triad. We conducted a narrative review of the relevant studies examining the MacDonald triad and its individual constituents. There is evidence that any one of the triad behaviors could predict future violent offending, but it is very rare to find all three behaviors together as predictors. Thus, the empirical research on the MacDonald triad does not fully substantiate its premise. Rather, it would appear that the triad, or its individual constituents, is better used as an indicator of dysfunctional home environments, or poor coping skills in children. Future research is needed with robust and rigorous methodologies (e.g., adequate control groups, longitudinal designs) to fully establish the MacDonald triad's validity. Finally, further consideration is needed as to whether the triad behaviors are more indicative of other problematic outcomes (e.g., maladaptive coping to life stressors).

Equivariant analogues of the Euler characteristic and Macdonald type equations

Science.gov (United States)

Gusein-Zade, S. M.

2017-02-01

One of the simplest and, at the same time, most important invariants of a topological space is the Euler characteristic. A generalization of the notion of the Euler characteristic to the equivariant setting, that is, to spaces with an action of a group (say, finite) is far from unique. An equivariant analogue of the Euler characteristic can be defined as an element of the ring of representations of the group or as an element of the Burnside ring of the group. From physics came the notion of the orbifold Euler characteristic, and this was generalized to orbifold Euler characteristics of higher orders. The main property of the Euler characteristic (defined in terms of the cohomology with compact support) is its additivity. On some classes of spaces there are additive invariants other than the Euler characteristic, and they can be regarded as generalized Euler characteristics. For example, the class of a variety in the Grothendieck ring of complex quasi-projective varieties is a universal additive invariant on the class of complex quasi-projective varieties. Generalized analogues of the Euler characteristic can also be defined in the equivariant setting. There is a simple formula — the Macdonald equation — for the generating series of the Euler characteristics of the symmetric powers of a space: it is equal to the series (1-t)-1=1+t+t^2+\\cdots independent of the space, raised to a power equal to the Euler characteristic of the space itself. Equations of a similar kind for other invariants (`equivariant and generalized Euler characteristics') are called Macdonald type equations. This survey discusses different versions of the Euler characteristic in the equivariant setting and describes some of their properties and Macdonald type equations. Bibliography: 59 titles.

Whittaker Vector of Deformed Virasoro Algebra and Macdonald Symmetric Functions

Science.gov (United States)

Yanagida, Shintarou

2016-03-01

We give a proof of Awata and Yamada's conjecture for the explicit formula of Whittaker vector of the deformed Virasoro algebra realized in the Fock space. The formula is expressed as a summation over Macdonald symmetric functions with factored coefficients. In the proof, we fully use currents appearing in the Fock representation of Ding-Iohara-Miki quantum algebra.

Stochastic higher spin six vertex model and Macdonald measures

Science.gov (United States)

Borodin, Alexei

2018-02-01

We prove an identity that relates the q-Laplace transform of the height function of a (higher spin inhomogeneous) stochastic six vertex model in a quadrant on one side and a multiplicative functional of a Macdonald measure on the other. The identity is used to prove the GUE Tracy-Widom asymptotics for two instances of the stochastic six vertex model via asymptotic analysis of the corresponding Schur measures.

Argyres-Douglas theories, the Macdonald index, and an RG inequality

Energy Technology Data Exchange (ETDEWEB)

Buican, Matthew [NHETC and Department of Physics and Astronomy, Rutgers University,Piscataway, NJ 08854 (United States); Enrico Fermi Institute and Department of Physics, The University of Chicago,Chicago, IL 60637 (United States); Nishinaka, Takahiro [NHETC and Department of Physics and Astronomy, Rutgers University,Piscataway, NJ 08854 (United States); Yukawa Institute for Theoretical Physics, Kyoto University,Kyoto 606-8502 (Japan)

2016-02-24

We conjecture closed-form expressions for the Macdonald limits of the superconformal indices of the (A{sub 1},A{sub 2n−3}) and (A{sub 1},D{sub 2n}) Argyres-Douglas (AD) theories in terms of certain simple deformations of Macdonald polynomials. As checks of our conjectures, we demonstrate compatibility with two S-dualities, we show symmetry enhancement for special values of n, and we argue that our expressions encode a non-trivial set of renormalization group flows. Moreover, we demonstrate that, for certain values of n, our conjectures imply simple operator relations involving composites built out of the SU(2){sub R} currents and flavor symmetry moment maps, and we find a consistent picture in which these relations give rise to certain null states in the corresponding chiral algebras. In addition, we show that the Hall-Littlewood limits of our indices are equivalent to the corresponding Higgs branch Hilbert series. We explain this fact by considering the S{sup 1} reductions of our theories and showing that the equivalence follows from an inequality on monopole quantum numbers whose coefficients are fixed by data of the four-dimensional parent theories. Finally, we comment on the implications of our work for more general N=2 superconformal field theories.

Argyres-Douglas theories, the Macdonald index, and an RG inequality

Science.gov (United States)

Buican, Matthew; Nishinaka, Takahiro

2016-02-01

We conjecture closed-form expressions for the Macdonald limits of the super-conformal indices of the ( A 1 , A 2 n - 3) and ( A 1 , D 2 n ) Argyres-Douglas (AD) theories in terms of certain simple deformations of Macdonald polynomials. As checks of our conjectures, we demonstrate compatibility with two S-dualities, we show symmetry enhancement for special values of n, and we argue that our expressions encode a non-trivial set of renormalization group flows. Moreover, we demonstrate that, for certain values of n, our conjectures imply simple operator relations involving composites built out of the SU(2) R currents and flavor symmetry moment maps, and we find a consistent picture in which these relations give rise to certain null states in the corresponding chiral algebras. In addition, we show that the Hall-Littlewood limits of our indices are equivalent to the corresponding Higgs branch Hilbert series. We explain this fact by considering the S 1 reductions of our theories and showing that the equivalence follows from an inequality on monopole quantum numbers whose coefficients are fixed by data of the four-dimensional parent theories. Finally, we comment on the implications of our work for more general {N}=2 superconformal field theories.

Argyres-Douglas theories, the Macdonald index, and an RG inequality

International Nuclear Information System (INIS)

Buican, Matthew; Nishinaka, Takahiro

2016-01-01

We conjecture closed-form expressions for the Macdonald limits of the superconformal indices of the (A 1 ,A 2n−3 ) and (A 1 ,D 2n ) Argyres-Douglas (AD) theories in terms of certain simple deformations of Macdonald polynomials. As checks of our conjectures, we demonstrate compatibility with two S-dualities, we show symmetry enhancement for special values of n, and we argue that our expressions encode a non-trivial set of renormalization group flows. Moreover, we demonstrate that, for certain values of n, our conjectures imply simple operator relations involving composites built out of the SU(2) R currents and flavor symmetry moment maps, and we find a consistent picture in which these relations give rise to certain null states in the corresponding chiral algebras. In addition, we show that the Hall-Littlewood limits of our indices are equivalent to the corresponding Higgs branch Hilbert series. We explain this fact by considering the S 1 reductions of our theories and showing that the equivalence follows from an inequality on monopole quantum numbers whose coefficients are fixed by data of the four-dimensional parent theories. Finally, we comment on the implications of our work for more general N=2 superconformal field theories.

Fluvial Responses to Holocene sea Level Variations Along the Macdonald River, New South Wales, Australia

Science.gov (United States)

Rustomji, P.; Chappell, J.; Olley, J.

2003-12-01

The Macdonald River drains the rugged eastern flanks of Australia's Great Dividing Range. It has a catchment area of 2000km2, restricted alluvial lowlands confined by bedrock interfluves and flows into the Hawkesbury River, a larger estuarine valley. The Macdonald valley is presently tidal for 14km from the Hawkesbury. At about 8000 year before present (BP), rising sea level invaded the Macdonald Valley for at least 35km upstream of the Hawkesbury River. Rapid aggradation occurred between 8000 and 6000 years BP and a sand bed river was established in the Macdonald Valley, its mouth prograding rapidly towards the Hawkesbury. Little is known about the character of the sand bed river during the +2 meter sea level highstand occurring between 5000 and 4000 BP. However, from 3000 to 1500 BP when sea level was consistently at +1 to +1.5m, major floodplain and levee-like structures, now virtually inactive, were established. The bed is inferred to have been elevated above its present day level and consequently intersected mean sea level (MSL) downstream of its present location. This is consistent with reported sea levels at +1 to +2m above present levels for the New South Wales coast at this time. From 1500 years BP, local sea level fell rapidly to its present level. Aggradation of the levee crests ceased and sedimentation along the valley became restricted to aggradation of an inset floodplain, within the pre-1500 BP deposits. The channel contracted and the sandy river bed incised. An equivalent and synchronous change in sedimentation style is observed along the Tuross River 400km south of the Macdonald, lending support to sea level variations being the factor driving this change. By 1850 AD, the bed dipped below MSL about 10km upstream of its inferred position prior to 1500 years BP. A series of large floods between 1949 and 1955 eroded significant volumes of sandy sediment from the Holocene deposits. The channel bed widened from between 25 and 50m width to ˜100m along

Macdonald farm demonstration woodlot: Annual report, 1994-1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

The MacDonald Farm Demonstration Woodlot is a parcel of forested land set aside to provide woodlot owners and the general public with an opportunity to see proper forest management techniques and the benefits of integrated resource management firsthand. This annual report provides information on the year`s operations in terms of outreach and education, infrastructure, on-site development and financial. Infrastructure includes road and trail construction. Objectives for the coming year are presented with information on the Woodlot Management Field Day, silvicultural treatments, wildlife, signage, brochures, staff training and the nature trail. Construction costs, a summary of silvicultural treatments, and financial statements are included. Descriptions and treatments used on each stand is included as well.

R-matrix arising from affine Hecke algebras and its application to Macdonald's difference operators

International Nuclear Information System (INIS)

Kato, Shinichi

1994-01-01

We shall give a certain trigonometric R-matrix associated with each root system by using affine Hecke algebras. From this R-matrix, we derive a quantum Knizhnik-Zamolodchikov equation after Cherednik, and show that the solutions of this KZ equation yield eigenfunctions of Macdonald's difference operators. (orig.)

Macdonald operators and homological invariants of the colored Hopf link

International Nuclear Information System (INIS)

Awata, Hidetoshi; Kanno, Hiroaki

2011-01-01

Using a power sum (boson) realization for the Macdonald operators, we investigate the Gukov, Iqbal, Kozcaz and Vafa (GIKV) proposal for the homological invariants of the colored Hopf link, which include Khovanov-Rozansky homology as a special case. We prove the polynomiality of the invariants obtained by GIKV's proposal for arbitrary representations. We derive a closed formula of the invariants of the colored Hopf link for antisymmetric representations. We argue that a little amendment of GIKV's proposal is required to make all the coefficients of the polynomial non-negative integers. (paper)

Optimization of the semiautomated Macdonald and Savage procedure

International Nuclear Information System (INIS)

Kuvik, V.; Vrbova, L.

1990-06-01

Several topics concerning the Macdonald and Savage (MD/S) procedure used for the potentiometric determination of plutonium were included in the programme of Analytical Services requested form CCL Rez. One part of the work was focussed on eliminating the variations of the Pu results and titems. The sulfuric reagent should be aged at least for one week. The optimal composition of the sulfuric reagent is 2M sulfuric acid + 0.2M sulfuric acid + 0.25 cerous nitrate. The excess of 0.002 N permanganate may vary between 0.016 and 0.1 ml. A variation of 0.02M oxalic acid between 0.08 and 0.14 ml is acceptable. The presence of Ga results in a slight positive bias of the Pu determination at ratio. Ga/Pu = 0.25. 3 refs, 18 tabs

Generalized Macdonald polynomials, spectral duality for conformal blocks and AGT correspondence in five dimensions

Energy Technology Data Exchange (ETDEWEB)

Zenkevich, Yegor [ITEP,25 Bolshaya Cheremushkinskaya street, Moscow (Russian Federation); Institute for Nuclear Research of the Russian Academy of Sciences,7a Prospekt 60-letiya Oktyabrya, Moscow (Russian Federation); NRNU Moscow Engineering Physics Institute,31 Kasirskoe chaussee, Moscow (Russian Federation)

2015-05-26

We study five dimensional AGT correspondence by means of the q-deformed beta-ensemble technique. We provide a special basis of states in the q-deformed CFT Hilbert space consisting of generalized Macdonald polynomials, derive the loop equations for the beta-ensemble and obtain the factorization formulas for the corresponding matrix elements. We prove the spectral duality for SU(2) Nekrasov functions and discuss its meaning for conformal blocks. We also clarify the relation between topological strings and q-Liouville vertex operators.

Generalized Macdonald polynomials, spectral duality for conformal blocks and AGT correspondence in five dimensions

International Nuclear Information System (INIS)

Zenkevich, Yegor

2015-01-01

We study five dimensional AGT correspondence by means of the q-deformed beta-ensemble technique. We provide a special basis of states in the q-deformed CFT Hilbert space consisting of generalized Macdonald polynomials, derive the loop equations for the beta-ensemble and obtain the factorization formulas for the corresponding matrix elements. We prove the spectral duality for SU(2) Nekrasov functions and discuss its meaning for conformal blocks. We also clarify the relation between topological strings and q-Liouville vertex operators.

Tableau Formulas for One-Row Macdonald Polynomials of Types C_n and D_n

Science.gov (United States)

Feigin, Boris; Hoshino, Ayumu; Noumi, Masatoshi; Shibahara, Jun; Shiraishi, Jun'ichi

2015-12-01

We present explicit formulas for the Macdonald polynomials of types C_n and D_n in the one-row case. In view of the combinatorial structure, we call them ''tableau formulas''. For the construction of the tableau formulas, we apply some transformation formulas for the basic hypergeometric series involving very well-poised balanced {}_{12}W_{11} series. We remark that the correlation functions of the deformed W algebra generators automatically give rise to the tableau formulas when we principally specialize the coordinate variables.

[Tributes to Macdonald Critchley and his achievements in neurolinguistics].

Science.gov (United States)

Hung, Tsu-Pei

2008-06-01

Macdonald Critchley, a world renowned neurologist, is best remembered as the person who challenged to solve the mystery and enigma of higher cerebral functions. He was the author of over 200 published articles and 20 books on neurology including his pioneer work on developmental dyslexia, the parietal lobe, cerebral hemisphere dominance and aphasiology. He also published articles on migraine, epilepsy, dementia, visual perseveration, anterior cerebral artery syndromes, indifference to pain, sleep disorders, movement disorders, and myotonia. He was very erudite and talented in linguistics; his interests were broad and eclectic. He wrote extensively on non-medical topics, such as plays, horror stories, mythology, and biographies of distinguished neuroscientists, philosophers or artists. His articles were written in the elegant prose style with thorough reference citations and extensive reviews of the literature worldwide. He was born in Bristol in 1900. From an early age, he was fascinated with the functioning brain and retained a life-long interest in languages. He was appointed to the Consultant staff of the National Hospital, Queen Square, and to King's College Hospital at the age of 27, and was elected to become FRCP at 30. He was Dean of the Institute of Neurology from 1948 to 1953. When I was studying advanced neurology at Queen Square in 1960-1961, I was fascinated by his outstanding lectures on Huntington's Disease and Non-verbal Communication. Although he did not read the manuscripts and used only a few slides for illustrations in his lectures, he could describe the details of historical accounts and relevant figures. He was an altruistic, instructive teacher with keen attention to responses from the audience. His clinical demonstrations, teaching rounds and tutorials were hugely popular among postgraduate students from all over the world. He emphasized the importance of shrewd observation and careful history taking in neurological practice. Macdonald

Managing Disruptive Physician Behavior: First Steps for Designing an Effective Online Resource

Directory of Open Access Journals (Sweden)

Derek Puddester

2011-03-01

Full Text Available Interviews with physician leaders from hospitals in a mid-sized Ontario City were conducted to determine their needs with regard to managing disruptive physician behaviour. These findings were used to inform the design of a two-day skill-development workshop for physician leaders on disruptive behaviour. The workshop was evaluated using a modified version of the Learner Experience Feedback Form, which was built to align with W(eLearn, http://www.ennovativesolution.com/WeLearn/ a framework developed to guide the design, delivery, development, and evaluation of online interprofessional courses and programs (MacDonald, Stodel, Thompson, & Casimiro, 2009. The surveys gathered information related to the content, media, service, structure, and outcomes of the workshop. The findings from the focus group interviews and workshop evaluation identify physician leaders’ needs with regard to disruptive behavior and were used to inform the design of the world’s first Online Physician Health and Wellness Resource http://www.ephysicianhealth.com/ an open access learning resources currently being used globally, in 91 countries. The resource was the recipient of the winner of the International Business/Professional 2010 International eLearning Award. The findings demonstrated the importance of conducting a needs analysis and using a framework to guide the design, delivery and evaluation of effective online healthcare education.

Chiral expansion and Macdonald deformation of two-dimensional Yang-Mills theory

Science.gov (United States)

Kökényesi, Zoltán; Sinkovics, Annamaria; Szabo, Richard J.

2016-11-01

We derive the analog of the large $N$ Gross-Taylor holomorphic string expansion for the refinement of $q$-deformed $U(N)$ Yang-Mills theory on a compact oriented Riemann surface. The derivation combines Schur-Weyl duality for quantum groups with the Etingof-Kirillov theory of generalized quantum characters which are related to Macdonald polynomials. In the unrefined limit we reproduce the chiral expansion of $q$-deformed Yang-Mills theory derived by de Haro, Ramgoolam and Torrielli. In the classical limit $q=1$, the expansion defines a new $\\beta$-deformation of Hurwitz theory wherein the refined partition function is a generating function for certain parameterized Euler characters, which reduce in the unrefined limit $\\beta=1$ to the orbifold Euler characteristics of Hurwitz spaces of holomorphic maps. We discuss the geometrical meaning of our expansions in relation to quantum spectral curves and $\\beta$-ensembles of matrix models arising in refined topological string theory.

Instanton counting, Macdonald function and the moduli space of D-branes

International Nuclear Information System (INIS)

Awata, Hidetoshi; Kanno, Hiroaki

2005-01-01

We argue the connection of Nekrasov's partition function in the Ω background and the moduli space of D-branes, suggested by the idea of geometric engineering and Gopakumar-Vafa invariants. In the instanton expansion of N = 2 SU(2) Yang-Mills theory the Nakrasov's partition function with equivariant parameters ε 1 ,ε 2 of toric action on C 2 factorizes correctly as the character of SU(2) L x SU(2) R spin representation. We show that up to two instantons the spin contents are consistent with the Lefschetz action on the moduli space of D2-branes on (local) F 0 . We also present an attempt at constructing a refined topological vertex in terms of the Macdonald function. The refined topological vertex with two parameters of T 2 action allows us to obtain the generating functions of equivariant χ y and elliptic genera of the Hilbert scheme of n points on C 2 by the method of topological vertex

Homage to Hersteinsson and Macdonald: climate warming and resource subsidies cause red fox range expansion and Arctic fox decline

OpenAIRE

Elmhagen, Bodil; Berteaux, Dominique; Burgess, Robert. M.; Ehrich, Dorothee; Gallant, Daniel; Henttonen, Heikki; Ims, Rolf Anker; Killengreen, Siw Turid; Niemimaa, Jukka; Norén, Karin; Ollila, Tuomo; Rodnikova, Anna Y.; Sokolov, Aleksandr A.; Sokolova, Natasha A.; Stickney, Alice A.

2017-01-01

Source at http://doi.org/10.1080/17518369.2017.1319109 Climate change can have a marked effect on the distribution and abundance of some species, as well as their interspecific interactions. In 1992, before ecological effects of anthropogenic climate change had developed into a topical research field, Hersteinsson and Macdonald published a seminal paper hypothesizing that the northern distribution limit of the red fox (Vulpes vulpes) is determined by food availability and ultim...

Commemorating John F. MacDonald and the Art of Being a Mentor.

Science.gov (United States)

Jackson, Michael F; Prado, Vania F; Prado, Marco A M

2016-09-01

John F. MacDonald was a close friend and mentor whose life was ended far too soon on April 22, 2014. To those who knew him, John was an endearing blend of fiery Scotsman, compassionate socialist, dedicated family man, and tireless investigator. Those close to him valued his loyalty and friendship, relished his biting wit, and puzzled at his self-deprecating manner. His career spanned a remarkable period of discovery from the early identification of excitatory amino acid, to the molecular cloning and characterization of glutamate receptors and the elucidation of mechanisms responsible for regulating their function. A true pioneer in each of these areas, John's research has had a lasting impact on our understanding of excitatory synaptic transmission and its plasticity. Our intent in commemorating John's work is to focus on some notable discoveries that highlight the impact and innovative aspects of John's work. In doing so, we also wish to highlight just how greatly our understanding of the glutamate transmitter systems has advanced since the late 1970s, when John first launched his independent neuroscience career.

The Macdonald and Savage titrimetric procedure scaled down to 4 mg sized plutonium samples. P. 1

International Nuclear Information System (INIS)

Kuvik, V.; Lecouteux, C.; Doubek, N.; Ronesch, K.; Jammet, G.; Bagliano, G.; Deron, S.

1992-01-01

The original Macdonald and Savage amperometric method scaled down to milligram-sized plutonium samples was further modified. The electro-chemical process of each redox step and the end-point of the final titration were monitored potentiometrically. The method is designed to determine 4 mg of plutonium dissolved in nitric acid solution. It is suitable for the direct determination of plutonium in non-irradiated fuel with a uranium-to-plutonium ratio of up to 30. The precision and accuracy are ca. 0.05-0.1% (relative standard deviation). Although the procedure is very selective, the following species interfere: vanadyl(IV) and vanadate (almost quantitatively), neptunium (one electron exchange per mole), nitrites, fluorosilicates (milligram amounts yield a slight bias) and iodates. (author). 15 refs.; 8 figs.; 7 tabs

MacDonald Dam reconstruction : using roller-compacted concrete

Energy Technology Data Exchange (ETDEWEB)

O' Neil, E. [AMEC Earth and Environmental Ltd., Sydney, NS (Canada)

2007-04-01

Located in Nova Scotia, the MacDonald Dam was commissioned in 1928. The dam consists of a 122 metre-long, 16 metre-high concrete structure comprised of an intake structure, stoplog openings, and a 34 metre-long free-overflow spillway. A 488 metre-long power canal was added as an upgrade in the 1950s. This paper provided details of the roller-compact concrete (RCC) used in the dam's recent rehabilitation following a dam failure analysis in 2003 by Nova Scotia Power Inc. RCC was chosen to help keep the dam's construction project on schedule. The layout and cross-section of the spillway was selected with consideration given to the RCC placing operation. A lift thickness of 0.20 m was selected. A formed ogee crest consisting of conventional reinforced concrete was constructed on top of the RCC. The downstream steps of the spillway were also covered with cast-in-place concrete. A low level sluice was designed to resist the weight of the wet RCC. The design compressive strength of the RCC was 20 MPa. The forms used to support the cast-in-place facing concrete on the upstream face of the dam were constructed full height and were braced back to the downstream face of the existing concrete structure prior to the start of RCC placement. Formwork inserts were placed in the facing concrete as construction progressed. Crack inducers were pre-placed on the forms. Aggregates from a local source were transported to a pug mill as the RCC construction progressed. The RCC was spread into 0.20 m lifts using a small bull-dozer, and the facing concrete was vibrated into the lift below. RCC lifts were compacted using a 9 tonne vibratory drum roller. The RCC placing operation was completed over a period of 10 days. Following the completion of the RCC portion of the dam, the remainder of the cast-in-place concrete was completed. It was concluded that the RCC provided a durable, low-maintenance structure that was completed at a lower price and in a shorter time-frame than

Form factors in sinh- and sine-Gordon models, deformed Virasoro algebra, Macdonald polynomials and resonance identities

International Nuclear Information System (INIS)

Lashkevich, Michael; Pugai, Yaroslav

2013-01-01

We continue the study of form factors of descendant operators in the sinh- and sine-Gordon models in the framework of the algebraic construction proposed in [1]. We find the algebraic construction to be related to a particular limit of the tensor product of the deformed Virasoro algebra and a suitably chosen Heisenberg algebra. To analyze the space of local operators in the framework of the form factor formalism we introduce screening operators and construct singular and cosingular vectors in the Fock spaces related to the free field realization of the obtained algebra. We show that the singular vectors are expressed in terms of the degenerate Macdonald polynomials with rectangular partitions. We study the matrix elements that contain a singular vector in one chirality and a cosingular vector in the other chirality and find them to lead to the resonance identities already known in the conformal perturbation theory. Besides, we give a new derivation of the equation of motion in the sinh-Gordon theory, and a new representation for conserved currents

The Q,T-catalan numbers and the space of diagonal harmonics with an appendix on the combinatorics of Macdonald polynomials

CERN Document Server

Haglund, James

2007-01-01

This book contains detailed descriptions of the many exciting recent developments in the combinatorics of the space of diagonal harmonics, a topic at the forefront of current research in algebraic combinatorics. These developments led in turn to some surprising discoveries in the combinatorics of Macdonald polynomials, which are described in Appendix A. The book is appropriate as a text for a topics course in algebraic combinatorics, a volume for self-study, or a reference text for researchers in any area which involves symmetric functions or lattice path combinatorics. The book contains expository discussions of some topics in the theory of symmetric functions, such as the practical uses of plethystic substitutions, which are not treated in depth in other texts. Exercises are interspersed throughout the text in strategic locations, with full solutions given in Appendix C.

THE PHYSIOLOGICAL AND MORPHOLOGICAL BASIS FOR OLFACTORY PERCEPTION OF STEROIDS DURING AGONISITC BEHAVIOR IN LOBSTER

Science.gov (United States)

During fighting, American lobsters urinate on each other with antennule flicking highest during this period. Blocking excretion of urine obliterates previously established dominance relationships, suggesting that individual recognition requires a urine signal (Breithaupt et al.,...

Reply to 'Photon emission from sputtered atoms - the observation of apparent local thermodynamic equilibrium in the excitation' by R.J. MacDonald, R.F. Garrett and P.J. Martin

International Nuclear Information System (INIS)

Tsong, I.S.T.

1978-01-01

MacDonald, Garrett and Martin have measured the intensities of spectral lines of Fe and Ni in alloy samples to study the problem of local thermodynamic equilibrium (LTE) in sputtering by plotting log(Ilambda 3 /gf) versus E. The measurements were made using a spectrometer with good resolution, 0.4 A, and great care was exercised in selecting only the lines free from interference or overlap. While the author agrees that their experimental approach is superior to the one attempted earlier and their experimental data are therefore more accurate, he does not agree with their data analysis. (Auth.)

The recognition of female voice based on voice registers in singing techniques in real-time using hankel transform method and macdonald function

Science.gov (United States)

Meiyanti, R.; Subandi, A.; Fuqara, N.; Budiman, M. A.; Siahaan, A. P. U.

2018-03-01

A singer doesn’t just recite the lyrics of a song, but also with the use of particular sound techniques to make it more beautiful. In the singing technique, more female have a diverse sound registers than male. There are so many registers of the human voice, but the voice registers used while singing, among others, Chest Voice, Head Voice, Falsetto, and Vocal fry. Research of speech recognition based on the female’s voice registers in singing technique is built using Borland Delphi 7.0. Speech recognition process performed by the input recorded voice samples and also in real time. Voice input will result in weight energy values based on calculations using Hankel Transformation method and Macdonald Functions. The results showed that the accuracy of the system depends on the accuracy of sound engineering that trained and tested, and obtained an average percentage of the successful introduction of the voice registers record reached 48.75 percent, while the average percentage of the successful introduction of the voice registers in real time to reach 57 percent.

Postoperative chemoradiation for resected gastric cancer - is the Macdonald Regimen Tolerable? a retrospective multi-institutional study

International Nuclear Information System (INIS)

Kundel, Yulia; Fenig, Eyal; Sulkes, Aaron; Brenner, Baruch; Purim, Ofer; Idelevich, Efraim; Lavrenkov, Konstantin; Man, Sofia; Kovel, Svetlana; Karminsky, Natalia; Pfeffer, Raphael M; Nisenbaum, Bella

2011-01-01

Postoperative chemoradiation as per Intergroup-0116 trial ('Macdonald regimen') is considered standard for completely resected high risk gastric cancer. However, many concerns remain with regards to the toxicity of this regimen. To evaluate the safety and tolerability of this regimen in a routine clinical practice setting, we analyzed our experience with its use. As we did not expect a different toxic profile in patients (pts) with positive margins (R1 resection), these were studied together with pts after complete resection (R0). Postoperative chemoradiation therapy was given according to the original Intergroup-0116 regimen. Overall survival (OS) and disease free survival (DFS) rates were calculated using the Kaplan-Meier method. Comparison of OS and DFS between R0 and R1 pts was done using the log-rank test. Between 6/2000 and 12/2007, 166 pts after R0 (129 pts) or R1 (37 pts) resection of locally advanced gastric adenocarcinoma received postoperative chemoradiation; 61% were male and the median age was 63 years (range, 23-86); 78% had T ≥ 3 tumors and 81% had N+ disease; 87% of the pts completed radiotherapy and 54% completed the entire chemoradiation plan; 46.4% had grade ≥ 3 toxicity and 32% were hospitalized at least once for toxicity. Three pts (1.8%) died of toxicity: diarrhea (1), neutropenic sepsis (1) and neutropenic sepsis complicated by small bowel gangrene (1). The most common hematological toxicity was neutropenia, grade ≥ 3 in 30% of pts and complicated by fever in 15%. The most common non-hematological toxicities were nausea, vomiting and diarrhea. With a median follow-up of 51 months (range, 2-100), 62% of the R0 patients remain alive and 61% are free of disease. Median DFS and OS for R0 were not reached. R0 pts had a significantly higher 3-year DFS (60% vs. 29%, p = 0.001) and OS (61% vs. 33%, p = 0.01) compared with R1 pts. In our experience, postoperative chemoradiation as per Intergroup-0116 seems to be substantially toxic

Stress fractures: definition, diagnosis and treatment ?

OpenAIRE

Astur, Diego Costa; Zanatta, Fernando; Arliani, Gustavo Gon?alves; Moraes, Eduardo Ramalho; Pochini, Alberto de Castro; Ejnisman, Benno

2015-01-01

ABSTRACT Stress fractures were first described in Prussian soldiers by Breithaupt in 1855. They occur as the result of repeatedly making the same movement in a specific region, which can lead to fatigue and imbalance between osteoblast and osteoclast activity, thus favoring bone breakage. In addition, when a particular region of the body is used in the wrong way, a stress fracture can occur even without the occurrence of an excessive number of functional cycles. The objective of this study wa...

An Expert System Model of Organizational Climate and Performance

Science.gov (United States)

1988-01-01

In 0. Meister, Behavioral analysis and measurement methods, New York: Wiley. Farace , R.V., and MacDonald, D. (1974). New directions in the study of...efficiency and resource use (EFFICIENCY). (Berlo in Farace and MacDonald, 1974) Commitment Communications Groups with greater commitment to goals...my work are correct and accurate (Muchlnsky, 1977; Klauss, 1977). ANSWERS.AVAIL S- 2. It’s easy to get answers in my organization ( Farace and MacDonald

77 FR 43115 - Notice of Temporary Closure of Betty's Kitchen Wildlife and Interpretive Area, Yuma County, AZ

Science.gov (United States)

2012-07-23

... officer. FOR FURTHER INFORMATION, CONTACT: John MacDonald, Yuma Field Manager, at 2555 East Gila Ridge... fines provided for in 18 U.S.C. 3571. Authority: 43 CFR 8364.1. John MacDonald, Field Manager. [FR Doc...

Genetics Home Reference: propionic acidemia

Science.gov (United States)

... Cerdá C, Scholl-Bürgi S, Skovby F, Wijburg F, MacDonald A, Martinelli D, Sass JO, Valayannopoulos V, Chakrapani ... Cerdá C, Scholl-Bürgi S, Skovby F, Wijburg F, MacDonald A, Martinelli D, Sass JO, Valayannopoulos V, Chakrapani ...

77 FR 2720 - Proposed Agreement and Covenant Not To Sue for the Colville Post & Poles Superfund Site, Stevens...

Science.gov (United States)

2012-01-19

.... MacDonald, Assistant Regional Counsel, U.S. Environmental Protection Agency, Region 10, 1200 Sixth Avenue, Suite 900, Seattle, Washington 98101; fax: (206) 553-1762; email: MacDonald[email protected] . FOR FURTHER INFORMATION CONTACT: Jennifer G. MacDonald, Assistant Regional Counsel, U.S. Environmental...

Mr MacDonald's suitcase

DEFF Research Database (Denmark)

2017-01-01

Undervisningsforløbet Mr. MacDonald’s suitcase beskriver læringsmålstyret undervisning i faget engelsk i 1. klasse, hvor der arbejdes med kompetenceområdet mundtlig kommunikation. Undervisningsforløbet er bygget op omkring en engelsk tøjdukke, der besøger klassen og fortæller små historier...

Experience and Sentence Processing: Statistical Learning and Relative Clause Comprehension

Science.gov (United States)

Wells, Justine B.; Christiansen, Morten H.; Race, David S.; Acheson, Daniel J.; MacDonald, Maryellen C.

2009-01-01

Many explanations of the difficulties associated with interpreting object relative clauses appeal to the demands that object relatives make on working memory. MacDonald and Christiansen [MacDonald, M. C., & Christiansen, M. H. (2002). "Reassessing working memory: Comment on Just and Carpenter (1992) and Waters and Caplan (1996)." "Psychological…

Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation

Directory of Open Access Journals (Sweden)

Paulo Linhares

2013-01-01

Full Text Available Introduction. The aim of this study was to determine the frequency of pseudoprogression in a cohort of glioblastoma (GBM patients following radiotherapy/temozolomide (RT/TMZ by comparing Macdonald criterial to Response Assessment in Neuro-Oncology (RANO criteria. The impact on prognosis and survival analysis was also studied. Materials and Methods. All patients receiving RT/TMZ for newly diagnosed GBM from January 2005 to December 2009 were retrospectively evaluated, and demographic, clinical, radiographic, treatment, and survival data were reviewed. Updated RANO criteria were used for the evaluation of the pre-RT and post-RT MRI and compared to classic Macdonald criteria. Survival data was evaluated using the Kaplan-Meier and log-rank analysis. Results and Discussion. 70 patients were available for full radiological response assessment. Early progression was confirmed in 42 patients (60% according to Macdonald criteria and 15 patients (21% according to RANO criteria. Pseudoprogression was identified in 10 (23.8% or 2 (13.3% patients in Macdonald and RANO groups, respectively. Cumulative survival of pseudoprogression group was higher than that of true progression group and not statistically different from the non-progressive disease group. Conclusion. In this cohort, the frequency of pseudoprogression varied between 13% and 24%, being overdiagnosed by older Macdonald criteria, which emphasizes the importance of RANO criteria and new radiological biomarkers for correct response evaluation.

The MacDonald and savage titrimetric procedure for plutonium scaled-down to the milligram level: Automated procedure for routine analysis of safeguards samples containing 2 to 5 mg plutonium

International Nuclear Information System (INIS)

Ronesch, K.; Jammet, G.; Berger, J.; Doubek, N.; Bagliano, G.; Deron, S.

1992-08-01

A selective titrimetric procedure directly applicable to both input and product solutions from fast reactor fuel reprocessing was set up by MacDonald and Savage and scaled down to 3 mg of plutonium in sample aliquots at the request of the Safeguards Analytical Laboratory (SAL) of the International Atomic Energy Agency (IAEA), which needed to replace its silver (II) oxide titration procedure by a more selective electrochemical method. Although the procedure is very selective the following species still interfere: Vanadates (almost quantitatively), Neptunium (one electron exchange per mole); Nitrites, Fluorosilicates and Iodates present in mg amount yield slight biases. This paper describes the fully automatized procedure presently applied in SAL for the routine determination of 2 to 5 mg plutonium dissolved in nitric acid solution. The method allows the unattended analysis of 20 aliquots within a five hour period. The equipment including the reagent distribution system, the sample changer and the control units are introduced and the principle design of the software is shortly described. Safety requirements have been addressed and are also reviewed in the report. Results obtained on standard reference materials, international intercomparison samples and actual safeguards samples routinely analyzed with the proposed procedure are presented and compared with results achieved with the semiautomatic mode to demonstrate the performance. International requirements to reduce the amount of radioactive materials in waste will certainly lead to a further reduction of the amount of plutonium in one aliquot. Some future perspective to titrate 1 mg samples are presented in the discussion. 12 refs, 10 figs, 8 tabs

Stress fractures: definition, diagnosis and treatment.

Science.gov (United States)

Astur, Diego Costa; Zanatta, Fernando; Arliani, Gustavo Gonçalves; Moraes, Eduardo Ramalho; Pochini, Alberto de Castro; Ejnisman, Benno

2016-01-01

Stress fractures were first described in Prussian soldiers by Breithaupt in 1855. They occur as the result of repeatedly making the same movement in a specific region, which can lead to fatigue and imbalance between osteoblast and osteoclast activity, thus favoring bone breakage. In addition, when a particular region of the body is used in the wrong way, a stress fracture can occur even without the occurrence of an excessive number of functional cycles. The objective of this study was to review the most relevant literature of recent years in order to add key information regarding this pathological condition, as an updating article on this topic.

Analysis of adjuvant treatment with chemoradiation in gastric cancer

International Nuclear Information System (INIS)

Fallas Solis, Elias

2008-01-01

The Hospital San Juan de Dios has analyzed the benefit of patients with gastric cancer who undergo surgery after receiving adjuvant chemoradiation. A retrospective study was performed reviewing records of patients during the period 1 January 2001 to December 31, 2005. These patients have been discharged with a diagnosis of gastric cancer and have received a complete resection with curative gastric malignancy and adjuvant chemoradiation according to the protocol established by Dr. MacDonald. In the study 0116. 743 patients were discharged to Hospital San Juan de Dios, 1 in 20 has been possible to diagnose gastric cancer at early stages for a total of 28 patients. The results obtained were compared at the Hospital San Juan de Dios with those published by Dr. MacDonald. The over-life of 3 years in the chemoradiation group in Hospital San Juan de Dios has been of 42.9% and 50% in the study MacDonald. The group that has not received adjuvant the over-life in the same period has been of 20 % in HSJD and 41% in the study MacDonald, being lower percentage of patients with this over-life, but greater range of difference. [es

Targeted Radiation Therapy for Cancer Initiative

Science.gov (United States)

2017-11-01

AWARD NUMBER: W81XWH-08-2-0174 TITLE: Targeted Radiation Therapy for Cancer Initiative PRINCIPAL INVESTIGATOR: Dusten Macdonald, MD...for Cancer Initiative 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Dusten Macdonald, MD 5d. PROJECT NUMBER...Cancer Initiative Final Report INTRODUCTION: The full potential of radiation therapy has not been realized due to the inability to locate and

Tunable Optical Tweezers for Wavelength-dependent Measurements

Science.gov (United States)

2012-04-23

have been studied in an optical levitation scheme over short laser wavelength ranges20 and for dye-loaded di- electric particles.21 In the first case...M. Block, IEEE J. Sel. Top. Quantum Electron. 2, 1066 (1996). 7K. Dholakia, W. M. Lee, L. Paterson, M. P. MacDonald, I. Andreev, P. Mthunzi, C. T. A...Brown, R. F. Marchington, and A. C. Riches, IEEE J. Sel. Top. Quantum Electron. 13, 1646 (2007). 8K. Dholakia, M. P. MacDonald, P. Zemanek, and T

Old MacDonald to Uncle Sam.

Science.gov (United States)

McCorkle, Sarapage, Ed.; Suiter, Mary, Ed.

This publication contains six lessons for elementary, middle, and high school classrooms developed by writers from Belarus, Croatia, Hungary, Kyrgyzstan, Romania, Russia, and the United States. The authors of these lessons were participants in the Training of Writers program developed and conducted by the National Council on Economic Education, as…

Twisted traces of quantum intertwiners and quantum dynamical R-matrices corresponding to generalized Belavin-Drinfeld triples

International Nuclear Information System (INIS)

Etingof, P.; Massachusetts Inst. of Tech., Cambridge, MA; Schiffmann, O.

2001-01-01

We consider weighted traces of products of intertwining operators for quantum groups U q (g), suitably twisted by a ''generalized Belavin-Drinfeld triple''. We derive two commuting sets of difference equations - the (twisted) Macdonald-Ruijsenaars system and the (twisted) quantum Knizhnik-Zamolodchikov-Bernard (qKZB) system. These systems involve the nonstandard quantum R-matrices defined in a previous joint work with T. Schedler (2000). When the generalized Belavin-Drinfeld triple comes from an automorphism of the Lie algebra g, we also derive two additional sets of difference equations, the dual Macdonald-Ruijsenaars system and the dual qKZB equations. (orig.)

Mirror Neurons and Literature: Empathy and the Sympathetic Imagination in the Fiction of J.M. Coetzee

Directory of Open Access Journals (Sweden)

Hilmar Heister

2015-01-01

Full Text Available In the two essays “The Philosophers and the Animals” and “The Poets and the Animals” (in The Lives of Animals, 1999 J.M. Coetzee lets Elizabeth Costello urge us to use our sympathetic imagination in order to access the experience of others—in particular, animals—and engage with them empathetically. Coetzee’s fiction illustrates how the use of the sympathetic imagination might evoke empathy in the reader. Narrative structure and the character’s mode of introspection engage the reader’s empathy through an ambivalent process of distancing and approximation, as Fritz Breithaupt puts forward in his narrative theory of empathy (Kulturen der Empathie, 2009. The sympathetic imagination and the complementary notion of embodiment feature prominently in Coetzee’s fictional discourse and resonate with neuroscience’s research on mirror neurons and their relation to empathy.

Nutritional Assesment in Cystic Fibrosis Patients( Iran and Newzeland

Directory of Open Access Journals (Sweden)

V Moeeni

2014-04-01

Full Text Available Introduction: Patients with Cystic Fibrosis have increased risk of malnutrition. Early detection of nutritional deterioration enables prompt intervention and correction. The aims of this project were to: - Define the nutritional status of CF patients in Iran and New Zealand -    Compare and contrast the MacDonald Nutritional Screening tool  with the Australasian guidelines for Nutrition in Cystic Fibrosis -    Validate these results in comparison with patient’s evaluation by their CF clinical team.   Materials and Methods: 69 CF patients (2-18 years were assessed during routine outpatient visits over one year. Anthropometric measurements were obtained. Both tools were applied for each patient and the results compared to their clinical evaluation (as gold standard with calculation of specificity and sensitivity. Results: Under-nutrition was more frequent in Iranian than NZ patients (39% versus 0%, p=0.0001, whereas over-nutrition was more prevalent in NZ children (9% versus 17%, p=0.05. At the first visit, MacDonald and Australasian guidelines were able to recognize 77% and 61% of under-nourished Iranian patients, respectively. The mean sensitivity and specificity for all visits for the MacDonald tool were 83% & 73% (Iran and 65% & 86% (NZ. Sensitivity and specificity for the Australasian guidelines were 79% & 79% (Iran and 70% & 90% (NZ. Conclusions: Both tools successfully recognised patients at risk of malnutrition. The MacDonald tool had comparable sensitivity and specificity to that described previously, especially in Iranian patients. This tool may be helpful in recognizing at risk CF patients, particularly in developing countries with fewer resources. Key words: Iran, Cystic Fibrosis Patient, Newzeland, Nutritional Assesment.

Response Assessment in Neuro-Oncology criteria, contrast enhancement and perfusion MRI for assessing progression in glioblastoma

Energy Technology Data Exchange (ETDEWEB)

Tensaouti, Fatima [Universite de Toulouse, Inserm, UPS, ToNIC, Toulouse NeuroImaging Center, Toulouse (France); Khalifa, Jonathan [Claudius Regaud Institute / Toulouse University Cancer Institute - Oncopole, Department of Radiation Oncology, Toulouse (France); Lusque, Amelie [Claudius Regaud Institute / Toulouse University Cancer Institute - Oncopole, Department of Biostatistics, Toulouse (France); Plas, Benjamin [CHU Toulouse, Department of Neurosurgery, Toulouse (France); Lotterie, Jean Albert; Berry, Isabelle [Universite de Toulouse, Inserm, UPS, ToNIC, Toulouse NeuroImaging Center, Toulouse (France); CHU Toulouse, Department of Nuclear Medicine, Toulouse (France); Laprie, Anne [Universite de Toulouse, Inserm, UPS, ToNIC, Toulouse NeuroImaging Center, Toulouse (France); Claudius Regaud Institute / Toulouse University Cancer Institute - Oncopole, Department of Radiation Oncology, Toulouse (France); Cohen-Jonathan Moyal, Elizabeth [Claudius Regaud Institute / Toulouse University Cancer Institute - Oncopole, Department of Radiation Oncology, Toulouse (France); Toulouse Center for Cancer Research (U1037), Inserm, Toulouse (France); Lubrano, Vincent [Universite de Toulouse, Inserm, UPS, ToNIC, Toulouse NeuroImaging Center, Toulouse (France); CHU Toulouse, Department of Neurosurgery, Toulouse (France)

2017-10-15

The purpose of the study was to evaluate Response Assessment in Neuro-Oncology (RANO) criteria in glioblastoma multiforme (GBM), with respect to the Macdonald criteria and changes in contrast-enhancement (CE) volume. Related variations in relative cerebral blood volume (rCBV) were investigated. Forty-three patients diagnosed between 2006 and 2010 were included. All underwent surgical resection, followed by temozolomide-based chemoradiation. MR images were retrospectively reviewed. Times to progression (TTPs) according to RANO criteria, Macdonald criteria and increased CE volume (CE-3D) were compared, and the percentage change in the 75th percentile of rCBV (rCBV75) was evaluated. After a median follow-up of 22.7 months, a total of 39 patients had progressed according to RANO criteria, 32 according to CE-3D, and 42 according to Macdonald. Median TTPs were 6.4, 9.3, and 6.6 months, respectively. Overall agreement was 79.07% between RANO and CE-3D and 93.02% between RANO and Macdonald. The mean percentage change in rCBV75 at RANO progression onset was over 73% in 87.5% of patients. In conclusion, our findings suggest that CE-3D criterion is not yet suitable to assess progression in routine clinical practice. Indeed, the accurate threshold is still not well defined. To date, in our opinion, early detection of disease progression by RANO combined with advanced MRI imaging techniques like MRI perfusion and diffusion remains the best way to assess disease progression. Further investigations that would examine the impact of treatment modifications after progression determined by different criteria on overall survival would be of great value. (orig.)

Response Assessment in Neuro-Oncology criteria, contrast enhancement and perfusion MRI for assessing progression in glioblastoma

International Nuclear Information System (INIS)

Tensaouti, Fatima; Khalifa, Jonathan; Lusque, Amelie; Plas, Benjamin; Lotterie, Jean Albert; Berry, Isabelle; Laprie, Anne; Cohen-Jonathan Moyal, Elizabeth; Lubrano, Vincent

2017-01-01

The purpose of the study was to evaluate Response Assessment in Neuro-Oncology (RANO) criteria in glioblastoma multiforme (GBM), with respect to the Macdonald criteria and changes in contrast-enhancement (CE) volume. Related variations in relative cerebral blood volume (rCBV) were investigated. Forty-three patients diagnosed between 2006 and 2010 were included. All underwent surgical resection, followed by temozolomide-based chemoradiation. MR images were retrospectively reviewed. Times to progression (TTPs) according to RANO criteria, Macdonald criteria and increased CE volume (CE-3D) were compared, and the percentage change in the 75th percentile of rCBV (rCBV75) was evaluated. After a median follow-up of 22.7 months, a total of 39 patients had progressed according to RANO criteria, 32 according to CE-3D, and 42 according to Macdonald. Median TTPs were 6.4, 9.3, and 6.6 months, respectively. Overall agreement was 79.07% between RANO and CE-3D and 93.02% between RANO and Macdonald. The mean percentage change in rCBV75 at RANO progression onset was over 73% in 87.5% of patients. In conclusion, our findings suggest that CE-3D criterion is not yet suitable to assess progression in routine clinical practice. Indeed, the accurate threshold is still not well defined. To date, in our opinion, early detection of disease progression by RANO combined with advanced MRI imaging techniques like MRI perfusion and diffusion remains the best way to assess disease progression. Further investigations that would examine the impact of treatment modifications after progression determined by different criteria on overall survival would be of great value. (orig.)

Determinants of Key Account Management Effectiveness: The Case ...

African Journals Online (AJOL)

Dires Abebe Fenta

relationship. KAM is a customer oriented approach in the modern relationship marketing ... services, customization of services, and information sharing. Macdonald ..... link between organizational factors and KAM effectiveness. Other factors.

Bodily tides near the 1:1 spin-orbit resonance: correction to Goldreich's dynamical model

Science.gov (United States)

Williams, James G.; Efroimsky, Michael

2012-12-01

Spin-orbit coupling is often described in an approach known as " the MacDonald torque", which has long become the textbook standard due to its apparent simplicity. Within this method, a concise expression for the additional tidal potential, derived by MacDonald (Rev Geophys 2:467-541, 1994), is combined with a convenient assumption that the quality factor Q is frequency-independent (or, equivalently, that the geometric lag angle is constant in time). This makes the treatment unphysical because MacDonald's derivation of the said formula was, very implicitly, based on keeping the time lag frequency-independent, which is equivalent to setting Q scale as the inverse tidal frequency. This contradiction requires the entire MacDonald treatment of both non-resonant and resonant rotation to be rewritten. The non-resonant case was reconsidered by Efroimsky and Williams (Cel Mech Dyn Astron 104:257-289, 2009), in application to spin modes distant from the major commensurabilities. In the current paper, we continue this work by introducing the necessary alterations into the MacDonald-torque-based model of falling into a 1-to-1 resonance. (The original version of this model was offered by Goldreich (Astron J 71:1-7, 1996). Although the MacDonald torque, both in its original formulation and in its corrected version, is incompatible with realistic rheologies of minerals and mantles, it remains a useful toy model, which enables one to obtain, in some situations, qualitatively meaningful results without resorting to the more rigorous (and complicated) theory of Darwin and Kaula. We first address this simplified model in application to an oblate primary body, with tides raised on it by an orbiting zero-inclination secondary. (Here the role of the tidally-perturbed primary can be played by a satellite, the perturbing secondary being its host planet. A planet may as well be the perturbed primary, its host star acting as the tide-raising secondary). We then extend the model to a

Rodrigues formulas for the non-symmetric multivariable polynomials associated with the BCN-type root system

International Nuclear Information System (INIS)

Nishino, Akinori; Ujino, Hideaki; Komori, Yasushi; Wadati, Miki

2000-01-01

The non-symmetric Macdonald-Koornwinder polynomials are joint eigenfunctions of the commuting Cherednik operators which are constructed from the representation theory for the affine Hecke algebra corresponding to the BC N -type root system. We present the Rodrigues formula for the non-symmetric Macdonald-Koornwinder polynomials. The raising operators are derived from the realizations of the corresponding double affine Hecke algebra. In the quasi-classical limit, the above theory reduces to that of the BC N -type Sutherland model which describes many particles with inverse-square long-range interactions on a circle with one impurity. We also present the Rodrigues formula for the non-symmetric Jacobi polynomials of type BC N which are eigenstates of the BC N -type Sutherland model

Cross-genus amplification and characterisation of microsatellite loci ...

African Journals Online (AJOL)

Cross-genus amplification and characterisation of microsatellite loci in the little free tailed bat, Chaerephon pumilus s. l. (Molossidae) from South Eastern Africa. Theshnie Naidoo, Angus Macdonald, Jennifer M Lamb ...

Raamatulett / Jaanus Tamm

Index Scriptorium Estoniae

Tamm, Jaanus

1996-01-01

Grazie, Marie Eugenie delle. Raamat armastusest; Macdonald, Finlay. Minu noorusmaa; Duckwell, Ernest Simon. Misery Halli saladus; Van Dine, S. S. Greene'i mõrvajuhtum; Van Dine, S. S. Kanaarilinnu mõrvajuhtum

Distribution of Shewanella putrefaciens and Desulfovibrio vulgaris in ...

African Journals Online (AJOL)

Distribution of Shewanella putrefaciens and Desulfovibrio vulgaris in sulphidogenic biofilms of industrial cooling water systems determined by fluorescent in situ hybridisation. Elise S McLeod, Raynard MacDonald, Volker S. Brozel ...

Recasting the theory of mosquito-borne pathogen transmission dynamics and control

Science.gov (United States)

Smith, David L.; Perkins, T. Alex; Reiner, Robert C.; Barker, Christopher M.; Niu, Tianchan; Chaves, Luis Fernando; Ellis, Alicia M.; George, Dylan B.; Le Menach, Arnaud; Pulliam, Juliet R. C.; Bisanzio, Donal; Buckee, Caroline; Chiyaka, Christinah; Cummings, Derek A. T.; Garcia, Andres J.; Gatton, Michelle L.; Gething, Peter W.; Hartley, David M.; Johnston, Geoffrey; Klein, Eili Y.; Michael, Edwin; Lloyd, Alun L.; Pigott, David M.; Reisen, William K.; Ruktanonchai, Nick; Singh, Brajendra K.; Stoller, Jeremy; Tatem, Andrew J.; Kitron, Uriel; Godfray, H. Charles J.; Cohen, Justin M.; Hay, Simon I.; Scott, Thomas W.

2014-01-01

Mosquito-borne diseases pose some of the greatest challenges in public health, especially in tropical and sub-tropical regions of the world. Efforts to control these diseases have been underpinned by a theoretical framework developed for malaria by Ross and Macdonald, including models, metrics for measuring transmission, and theory of control that identifies key vulnerabilities in the transmission cycle. That framework, especially Macdonald's formula for R0 and its entomological derivative, vectorial capacity, are now used to study dynamics and design interventions for many mosquito-borne diseases. A systematic review of 388 models published between 1970 and 2010 found that the vast majority adopted the Ross–Macdonald assumption of homogeneous transmission in a well-mixed population. Studies comparing models and data question these assumptions and point to the capacity to model heterogeneous, focal transmission as the most important but relatively unexplored component in current theory. Fine-scale heterogeneity causes transmission dynamics to be nonlinear, and poses problems for modeling, epidemiology and measurement. Novel mathematical approaches show how heterogeneity arises from the biology and the landscape on which the processes of mosquito biting and pathogen transmission unfold. Emerging theory focuses attention on the ecological and social context for mosquito blood feeding, the movement of both hosts and mosquitoes, and the relevant spatial scales for measuring transmission and for modeling dynamics and control. PMID:24591453

Recasting the theory of mosquito-borne pathogen transmission dynamics and control.

Science.gov (United States)

Smith, David L; Perkins, T Alex; Reiner, Robert C; Barker, Christopher M; Niu, Tianchan; Chaves, Luis Fernando; Ellis, Alicia M; George, Dylan B; Le Menach, Arnaud; Pulliam, Juliet R C; Bisanzio, Donal; Buckee, Caroline; Chiyaka, Christinah; Cummings, Derek A T; Garcia, Andres J; Gatton, Michelle L; Gething, Peter W; Hartley, David M; Johnston, Geoffrey; Klein, Eili Y; Michael, Edwin; Lloyd, Alun L; Pigott, David M; Reisen, William K; Ruktanonchai, Nick; Singh, Brajendra K; Stoller, Jeremy; Tatem, Andrew J; Kitron, Uriel; Godfray, H Charles J; Cohen, Justin M; Hay, Simon I; Scott, Thomas W

2014-04-01

Mosquito-borne diseases pose some of the greatest challenges in public health, especially in tropical and sub-tropical regions of the world. Efforts to control these diseases have been underpinned by a theoretical framework developed for malaria by Ross and Macdonald, including models, metrics for measuring transmission, and theory of control that identifies key vulnerabilities in the transmission cycle. That framework, especially Macdonald's formula for R0 and its entomological derivative, vectorial capacity, are now used to study dynamics and design interventions for many mosquito-borne diseases. A systematic review of 388 models published between 1970 and 2010 found that the vast majority adopted the Ross-Macdonald assumption of homogeneous transmission in a well-mixed population. Studies comparing models and data question these assumptions and point to the capacity to model heterogeneous, focal transmission as the most important but relatively unexplored component in current theory. Fine-scale heterogeneity causes transmission dynamics to be nonlinear, and poses problems for modeling, epidemiology and measurement. Novel mathematical approaches show how heterogeneity arises from the biology and the landscape on which the processes of mosquito biting and pathogen transmission unfold. Emerging theory focuses attention on the ecological and social context for mosquito blood feeding, the movement of both hosts and mosquitoes, and the relevant spatial scales for measuring transmission and for modeling dynamics and control.

Modelling of crack chemistry in sensitized stainless steel in boiling water reactor environments

International Nuclear Information System (INIS)

Turnbull, A.

1997-01-01

An advanced model has been used to predict the chemistry and potential in a stress corrosion crack in sensitized stainless steel in a boiling water reactor (BWR) environment. The model assumes trapezoidal crack geometry, incorporates anodic reaction and cathodic reduction within the crack, and takes into account the limited solubility of cations in high temperature water. The results indicate that the crack tip potential is not independent of the external potential, and that the reactions on the walls of the crack must be included for reliable prediction. Accordingly, both the modelling assumptions of Ford and Andresen and of Macdonald and Urquidi-Macdonald, whilst having merit, are not fully satisfactory. Extended application of the model for improved prediction of stress corrosion crack growth rate is constrained by limitations in electrochemical data which are currently inadequate. (author)

Proving AGT conjecture as HS duality: Extension to five dimensions

International Nuclear Information System (INIS)

Mironov, A.; Morozov, A.; Shakirov, Sh.; Smirnov, A.

2012-01-01

We extend the proof from Mironov et al. (2011) , which interprets the AGT relation as the Hubbard-Stratonovich duality relation to the case of 5d gauge theories. This involves an additional q-deformation. Not surprisingly, the extension turns out to be straightforward: it is enough to substitute all relevant numbers by q-numbers in all the formulas, Dotsenko-Fateev integrals by the Jackson sums and the Jack polynomials by the MacDonald ones. The problem with extra poles in individual Nekrasov functions continues to exist, therefore, such a proof works only for β=1, i.e. for q=t in MacDonald's notation. For β≠1 the conformal blocks are related in this way to a non-Nekrasov decomposition of the LMNS partition function into a double sum over Young diagrams.

Panmixia in east African Platgyra daedalea | Macdonald | Western ...

African Journals Online (AJOL)

Reef coral populations in the western Indian Ocean are neglected in terms of research and management. Very little is known about coral population connectivity and dynamics at regional scales. Platygyra daedalea was collected from Indian Ocean coral reefs, mainly from the east African coast between Mombasa Marine ...

Rich dynamics of a food chain model with ratio-dependent type III ...

African Journals Online (AJOL)

user

prey dynamics is to incorporate discrete delay into the predator equations. ... models may be found in classical books of Gopalsamy (1992), Macdonald (1989) .... Model (1) has 10 parameters in all, which make mathematical analysis complex.

Epilepsy or seizures - discharge

Science.gov (United States)

... and the people you work with about your seizure disorder. Driving your own car is generally safe and ... References Abou-Khalil BW, Gallagher MJ, Macdonald RL. Epilepsies. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy ...

77 FR 45869 - Endangered and Threatened Wildlife and Plants; Listing the British Columbia Distinct Population...

Science.gov (United States)

2012-08-01

... prey available (Ethier 1999, p. 22; MacDonald and Cook 1999, pp. 23-24; Nagorsen 2002, pp. 92-97; Doyle... nesting activity (percentage of nest areas with eggs laid) appear to vary with habitat suitability, prey...

Genetics Home Reference: genetic epilepsy with febrile seizures plus

Science.gov (United States)

... LA, Hodgson BL, Scott D, Jenkins M, Petrou S, Sutherland GR, Scheffer IE, Berkovic SF, Macdonald RL, Mulley ... RH, Scheffer IE, Parasivam G, Barnett S, Wallace GB, Sutherland GR, Berkovic SF, Mulley JC. Generalized epilepsy with ...

J. B. S. Haldane: the John Innes years

Indian Academy of Sciences (India)

SARAH WILMOT

2017-11-24

Nov 24, 2017 ... ber of J. Ramsay MacDonald's new Economic Advisory. Council. Hall offered to ... were being left unfilled until the books could be balanced. The income available to ...... Harvard University Press, Cambridge,. Mass. Lawrence ...

Animal Research International - Vol 9, No 2 (2012)

African Journals Online (AJOL)

Effects of Piliostigma thonningii ethyl acetate leaf extract on aluminium-cum extract treated wistar rats · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Macdonald O Ighodaro, JO Omole, SO Fadipe ...

Primary volcanic structures from a type section of Deccan Trap flows ...

Indian Academy of Sciences (India)

Swanson 1967; Macdonald 1967; Long and Wood. Keywords. Deccan Traps; lava flows; volcanism; isotherm; cooling history. J. Earth Syst. Sci. 115, No. ...... Kilauea Volcanic island of Hawaii; J. Geophys. Res. 103. 27,303–27,323. Lightfoot ...

Cardiac Disease in Pregnancy - a four-year audit at Pretoria ...

African Journals Online (AJOL)

2002-2005). P Soma-Pillay, AP Macdonald, T Mathivha, J Bakker, M Mackintoch. Abstract. Background. Pre-existing medical disease constitutes one of the five major causes of maternal death in South Africa. Increasing numbers of women with ...

Comparative changes in monthly blood urea nitrogen, total protein ...

African Journals Online (AJOL)

Sibanda M

2015-03-29

Mar 29, 2015 ... Twenty-four clinically healthy animals in different parities, namely Parity 1 ..... In the dry spell there is low protein intake because of high fibrous diets from dry forage materials. (MacDonald .... Prentice Hall, Malaysia. Mapekula ...

New Integrals Arising in the Samara-Valencia Heat Transfer Model in Grinding

Directory of Open Access Journals (Sweden)

J. L. González-Santander

2017-01-01

Full Text Available The Samara-Valencia model for heat transfer in grinding has been recently used for calculating nontabulated integrals. Based on these results, new infinite integrals can be calculated, involving the Macdonald function and the modified Struve function.

Pikantsed pajatused / Aita Kivi

Index Scriptorium Estoniae

Kivi, Aita, 1954-

2000-01-01

Sisu : Louis Paul Boon. Menuett; Herbjırg Wassmo. Õnne poeg; Jean Stone. Sünnipäevatüdrukud; Jo︠l Schmidt. Constantinus Suure mälestused; Mari Vallisoo. Ainsuse olevik; Catherine Coulter. Märklaud; Ross Macdonald. Mees mulla all

Husserl's Preemptive Responses to Existentialist Critiques ...

African Journals Online (AJOL)

Husserl's Preemptive Responses to Existentialist Critiques. Paul S MacDonald. Abstract. Existentialist thinkers often publicly acknowledged Husserl's phenomenology as one of their main points of departure for treatment of such themes as intentionality, comportment, transcendence, and the lifeworld. Several central ...

A simple route to maximum-likelihood estimates of two-locus

Indian Academy of Sciences (India)

Home; Journals; Journal of Genetics; Volume 94; Issue 3. A simple route to maximum-likelihood estimates of two-locus recombination fractions under inequality restrictions. Iain L. Macdonald Philasande Nkalashe. Research Note Volume 94 Issue 3 September 2015 pp 479-481 ...

On an integral transform

Directory of Open Access Journals (Sweden)

D. Naylor

1986-01-01

Full Text Available This paper establishes properties of a convolution type integral transform whose kernel is a Macdonald type Bessel function of zero order. An inversion formula is developed and the transform is applied to obtain the solution of some related integral equations.

South African Journal of Animal Science - Vol 22, No 3 (1992)

African Journals Online (AJOL)

Chemical composition and nutritive value of irrigated tall fescue pasture for dairy cows · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. TJ Dugmore, KP Walsh, Sally J. Morning, CI MacDonald, 81-86 ...

Nigerian Quarterly Journal of Hospital Medicine - Vol 13, No 3-4 ...

African Journals Online (AJOL)

Mast Cell Quantification in Orofacial Granulomatosis · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. N N Nwizu, D G Macdonald, 34-39. http://dx.doi.org/10.4314/nqjhm.v13i3-4.12653 ...

Post-radiational ureteric fibrosis with extrarenal renal failure as a rare complication after adjuvant treatment of gastric cancer - a case report

International Nuclear Information System (INIS)

Swieboda-Sadlej, A.; Staszewska-Skurczynska, M.; Piyush Vyas; Zurawinska, E.; Heleniak, H.; Kocik, J.; Danek, A.; Tragarz, E.

2008-01-01

The principles of chemoradiotherapy for treating patients with radically resected gastric cancer are not fully established. In many oncological centres patients with unfavourable prognostic factors who previously had radical gastrectomy are treated with Macdonald regimen which includes combined fluorouracil with radiotherapy. Statistics indicate that more then 30% patients treated with chemoradiotherapy suffer from serious complication. In this article we describe a case of a patient who developed ureteric fibrosis with consequent renal failure as a rare life threatening complication of Macdonald regimen. The patient received chemoradiotherapy because of unfavourable prognostic factors and good performance status however he was in advanced age and with other comorbidities. These data support the notion of the high toxicity of this regimen and suggest that selection of patients for this treatment should be done very carefully. This is discussed in the context of other available therapies in gastric cancer. (author)

The Neurologic Assessment in Neuro-Oncology (NANO) Scale as an Assessment Tool for Survival in Patients With Primary Glioblastoma.

Science.gov (United States)

Ung, Timothy H; Ney, Douglas E; Damek, Denise; Rusthoven, Chad G; Youssef, A Samy; Lillehei, Kevin O; Ormond, D Ryan

2018-03-30

The Neurologic Assessment in Neuro-Oncology (NANO) scale is a standardized objective metric designed to measure neurological function in neuro-oncology. Current neuroradiological evaluation guidelines fail to use specific clinical criteria for progression. To determine if the NANO scale was a reliable assessment tool in glioblastoma (GBM) patients and whether it correlated to survival. Our group performed a retrospective review of all patients with newly diagnosed GBM from January 1, 2010, through December 31, 2012, at our institution. We applied the NANO scale, Karnofsky performance score (KPS), Eastern Cooperative Oncology Group (ECOG) scale, Macdonald criteria, and the Response Assessment in Neuro-Oncology (RANO) criteria to patients at the time of diagnosis as well as at 3, 6, and 12 mo. Initial NANO score was correlated with overall survival at time of presentation. NANO progression was correlated with decreased survival in patients at 6 and 12 mo. A decrease in KPS was associated with survival at 3 and 6 mo, an increase in ECOG score was associated only at 3 mo, and radiological evaluation (RANO and Macdonald) was correlated at 3 and 6 mo. Only the NANO scale was associated with patient survival at 1 yr. NANO progression was the only metric that was linked to decreased overall survival when compared to RANO and Macdonald at 6 and 12 mo. The NANO scale is specific to neuro-oncology and can be used to assess patients with glioma. This retrospective analysis demonstrates the usefulness of the NANO scale in glioblastoma.

Generalized Weyl modules for twisted current algebras

Science.gov (United States)

Makedonskyi, I. A.; Feigin, E. B.

2017-08-01

We introduce the notion of generalized Weyl modules for twisted current algebras. We study their representation-theoretic and combinatorial properties and also their connection with nonsymmetric Macdonald polynomials. As an application, we compute the dimension of the classical Weyl modules in the remaining unknown case.

Timing of antenatal care and ART initiation in HIV-infected pregnant ...

African Journals Online (AJOL)

3 Health and Development Africa, Mott MacDonald South Africa. 4 Epidemiology and Biostatistics Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand,. Johannesburg, South Africa. 5 Department of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, South Africa.

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Genetics. Philasande Nkalashe. Articles written in Journal of Genetics. Volume 94 Issue 3 September 2015 pp 479-481 Research Note. A simple route to maximum-likelihood estimates of two-locus recombination fractions under inequality restrictions · Iain L. Macdonald Philasande Nkalashe.

Attention and Facilitation: Converging Information Versus Inadvertent Reading in Stroop Task Performance

NARCIS (Netherlands)

Roelofs, A.P.A.

2010-01-01

Disagreement exists about whether color-word Stroop facilitation is caused by converging information (e.g.. Cohen et al.. 1990: Roelofs, 2003) or inadvertent reading (MacLeod & MacDonald, 2000). Four experiments tested between these hypotheses by examining Stroop effects oil response time (RT) both

Husserl, the Monad and Immortality | MacDonald | Indo-Pacific ...

African Journals Online (AJOL)

In an Appendix to his Analyses Concerning Passive and Active Synthesis dating from the early 1920s, Husserl makes the startling assertion that, unlike the mundane ego, the transcendental ego is immortal. The present paper argues that this claim is an ineluctable consequence of Husserl's relentless pursuit of the ever ...

Husserl, the Monad and Immortality | MacDonald | Indo-Pacific ...

African Journals Online (AJOL)

Indo-Pacific Journal of Phenomenology. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 7, No 2 (2007) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Download this PDF file. The PDF file you selected ...

A review of cricket Fielding requirements | MacDonald | South ...

African Journals Online (AJOL)

South African Journal of Sports Medicine. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 25, No 3 (2013) >. Log in or Register to get access to full text downloads.

Processing of audiovisual stimuli in aphasic and non-brain-damaged listeners

NARCIS (Netherlands)

Hessler, Dorte; Jonkers, Roel; Bastiaanse, Roelien; de Kok, D.A.

2012-01-01

Background: During speech perception not only auditory but also visual information (seen speech) is processed. This was shown by, for example, McGurk and MacDonald (1976). In their study participants watched videos showing a speaker articulating the syllable /ka/, while the sound of /pa/ was dubbed

Carcinoid of the Rectum

African Journals Online (AJOL)

1974-06-01

Jun 1, 1974 ... MacDonald' regarded all extra-appendiceal carcinoids as malignant and described a classification of invasiveness. CASE REPORT. A Black male aged 60 years was admitted to hospital in. January 1973 complaining of discomfort on defaecation. Department of Surgery and Gastro-intestinal Unit, University.

A Case for Criminal Enforcement of Federal Environmental Laws

Science.gov (United States)

1989-02-19

enforcement scheme can actually contribute to improper disposal. Szasz , Corporations. Organized Crime. and the Disposal of Hazardous Waste: An...the Syndicate Control Mystiaue, 1 Nat’l Envtl. Enforcement J. 3 (Dec. 1986). 150. See Szasz , supra note 79. 151. United States v. MacDonald & Watson

Decomposing Nekrasov decomposition

International Nuclear Information System (INIS)

Morozov, A.; Zenkevich, Y.

2016-01-01

AGT relations imply that the four-point conformal block admits a decomposition into a sum over pairs of Young diagrams of essentially rational Nekrasov functions — this is immediately seen when conformal block is represented in the form of a matrix model. However, the q-deformation of the same block has a deeper decomposition — into a sum over a quadruple of Young diagrams of a product of four topological vertices. We analyze the interplay between these two decompositions, their properties and their generalization to multi-point conformal blocks. In the latter case we explain how Dotsenko-Fateev all-with-all (star) pair “interaction” is reduced to the quiver model nearest-neighbor (chain) one. We give new identities for q-Selberg averages of pairs of generalized Macdonald polynomials. We also translate the slicing invariance of refined topological strings into the language of conformal blocks and interpret it as abelianization of generalized Macdonald polynomials.

Decomposing Nekrasov decomposition

Energy Technology Data Exchange (ETDEWEB)

Morozov, A. [ITEP,25 Bolshaya Cheremushkinskaya, Moscow, 117218 (Russian Federation); Institute for Information Transmission Problems,19-1 Bolshoy Karetniy, Moscow, 127051 (Russian Federation); National Research Nuclear University MEPhI,31 Kashirskoe highway, Moscow, 115409 (Russian Federation); Zenkevich, Y. [ITEP,25 Bolshaya Cheremushkinskaya, Moscow, 117218 (Russian Federation); National Research Nuclear University MEPhI,31 Kashirskoe highway, Moscow, 115409 (Russian Federation); Institute for Nuclear Research of Russian Academy of Sciences,6a Prospekt 60-letiya Oktyabrya, Moscow, 117312 (Russian Federation)

2016-02-16

AGT relations imply that the four-point conformal block admits a decomposition into a sum over pairs of Young diagrams of essentially rational Nekrasov functions — this is immediately seen when conformal block is represented in the form of a matrix model. However, the q-deformation of the same block has a deeper decomposition — into a sum over a quadruple of Young diagrams of a product of four topological vertices. We analyze the interplay between these two decompositions, their properties and their generalization to multi-point conformal blocks. In the latter case we explain how Dotsenko-Fateev all-with-all (star) pair “interaction” is reduced to the quiver model nearest-neighbor (chain) one. We give new identities for q-Selberg averages of pairs of generalized Macdonald polynomials. We also translate the slicing invariance of refined topological strings into the language of conformal blocks and interpret it as abelianization of generalized Macdonald polynomials.

Short Communication Estimation of size at first maturity in two South ...

African Journals Online (AJOL)

Short Communication Estimation of size at first maturity in two South African coral species. ... African Journal of Marine Science ... PH Montoya-Maya, AHH Macdonald, MH Schleyer ... to differentiate juveniles from adult sizes of corals, an important factor for assessing the condition of scleractinian communities in reefs. Here ...

developments in environmental education in new zealand

African Journals Online (AJOL)

... subscribe to the dominant social paradigm in which consumption, .... involved the sale of state assets to private owners, ... impact of these changes have been described by a number ..... Network, and the Royal Forest and Bird Protection. Society. .... ing advertisements on television and in print and .... Macdonald, J. 1998.

A Review of Rate Coefficients in the D2-F2 Chemical Laser System

Science.gov (United States)

1977-08-05

analyzed by subjecting the mixture to a high-frequency dis- charge, then using EPR to assay the relative H and D atom concentrations. The rate...856 ( 1935 ). Anlauf, K. G. , P. E. Charters, D. S. Home, R. G. MacDonald, D. II. Maylotte, J. C. Polanyi, W. J

75 FR 74736 - Food Labeling Workshop; Public Workshop

Science.gov (United States)

2010-12-01

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0001..., Lincoln Way and University Avenue, Iowa State Center, Ames, IA. Contact: David Arvelo, Food and Drug... payable to ``Iowa State University.'' Mail to: Dr. Ruth MacDonald, Food Science and Human Nutrition, 2312...

South African Medical Journal - Vol 89, No 8 (1999)

African Journals Online (AJOL)

The use of dexamethasone in women with preterm premature rupture of membranes - A multicentre, double-blind, placebocontrolled, randomised trial · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. R.C. Pattinson, J.D. Makin, M. Funk, S.D. Delport, A.P. Macdonald, ...

Microbial Load of Some Medicinal Plants Sold in Some Local ...

African Journals Online (AJOL)

Microbial Load of Some Medicinal Plants Sold in Some Local Markets in Abeokuta, Nigeria. I MacDonald, S Omonigho, J Erhabor, H Efijuemue. Abstract. Purpose: To evaluate the microbial load on 17 randomly selected plant samples from 60 ethnobotanically collected medicinal plants from five local markets in Abeokuta, ...

Book Reviews | Sheppey | African Zoology

African Journals Online (AJOL)

Book Authors: Edited by Richard E. Brown & David W. Macdonald. Oxford University Press, Oxford, 1985. 556 pp. Book Review 4. Book Title: Biology of Communication. Book Authors: D. Brian Lewis & D. Michael Gower. Blackie & Son, Glasgow. 239 pp. Book Review 5. Book Title: Animal Osmoregulation. Book Authors: J.

Download this PDF file

African Journals Online (AJOL)

Wildlife and Environmental Society of Malawi, Blantyre. Lipiya, A. 2011. Status of Birds of Prey, with Special Emphasis on Vultures, in Kasungu. National Park. Unpublished report. Department of National Parks and Wildlife,. Lilongwe. 5pp. MacDonald, L. 2011. Recent Sightings. Vocifer. A Bulletin of Ornithological News in.

Severe acute maternal morbidity and maternal death audit - a rapid ...

African Journals Online (AJOL)

Severe acute maternal morbidity and maternal death audit - a rapid diagnostic tool for evaluating maternal care. L Cochet, R.C. Pattinson, A.P. Macdonald. Abstract. Objective. To analyse severe acute maternal morbidity (SAMM) and maternal mortality in the Pretoria region over a 2-year period (2000 - 2001). Setting.

High-Ti type N-MORB parentage of basalts from the south Andaman ...

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

by Irvine and Baragar (1971) or MacDonald and. Katsura (1964) were not included here because of the considerable uncertainty that exists in such a classification scheme (see Sheth et al 2002 for more explanation). The Andaman ophiolite samples are mainly basalts (20 samples), with some basaltic andesites.

Alienation, Mass Society and Mass Culture.

Science.gov (United States)

Dam, Hari N.

This monograph examines the nature of alienation in mass society and mass culture. Conceptually based on the "Gemeinschaft-Gesellschaft" paradigm of sociologist Ferdinand Tonnies, discussion traces the concept of alienation as it appears in the philosophies of Hegel, Marx, Kierkegaard, Sartre, and others. Dwight Macdonald's "A Theory of Mass…

Comment on Geoengineering with seagrasses: is credit due where credit is given?

Science.gov (United States)

Oreska, Matthew P. J.; McGlathery, Karen J.; Emmer, Igino M.; Needelman, Brian A.; Emmett-Mattox, Stephen; Crooks, Stephen; Megonigal, J. Patrick; Myers, Doug

2018-03-01

In their recent review, ‘Geoengineering with seagrasses: is credit due where credit is given?,’ Johannessen and Macdonald (2016) invoke the prospect of carbon offset-credit over-allocation by the Verified Carbon Standard as a pretense for their concerns about published seagrass carbon burial rate and global stock estimates. Johannessen and Macdonald (2016) suggest that projects seeking offset-credits under the Verified Carbon Standard methodology VM0033: Methodology for Tidal Wetland and Seagrass Restoration will overestimate long-term (100 yr) sediment organic carbon (SOC) storage because issues affecting carbon burial rates bias storage estimates. These issues warrant serious consideration by the seagrass research community; however, VM0033 does not refer to seagrass SOC ‘burial rates’ or ‘storage.’ Projects seeking credits under VM0033 must document greenhouse gas emission reductions over time, relative to a baseline scenario, in order to receive credits. Projects must also monitor changes in carbon pools, including SOC, to confirm that observed benefits are maintained over time. However, VM0033 allows projects to conservatively underestimate project benefits by citing default values for specific accounting parameters, including CO2 emissions reductions. We therefore acknowledge that carbon crediting methodologies such as VM0033 are sensitive to the quality of the seagrass literature, particularly when permitted default factors are based in part on seagrass burial rates. Literature-derived values should be evaluated based on the concerns raised by Johannessen and Macdonald (2016), but these issues should not lead to credit over-allocation in practice, provided VM0033 is rigorously followed. These issues may, however, affect the feasibility of particular seagrass offset projects.

Advantages of high b-value diffusion-weighted imaging to diagnose pseudo-responses in patients with recurrent glioma after bevacizumab treatment

International Nuclear Information System (INIS)

Yamasaki, Fumiyuki; Kurisu, Kaoru; Aoki, Tomokazu; Yamanaka, Masami; Kajiwara, Yoshinori; Watanabe, Yosuke; Takayasu, Takeshi; Akiyama, Yuji; Sugiyama, Kazuhiko

2012-01-01

Background: The diagnosis of pseudo-responses after bevacizumab treatment is difficult. Because diffusion-weighted imaging (DWI) is associated with cell density, it may facilitate the differentiation between true- and pseudo-responses. Furthermore, as high b-value DWI is even more sensitive to diffusion, it has been reported to be diagnostically useful in various clinical settings. Materials and methods: Between September 2008 and May 2011, 10 patients (5 males, 5 females; age range 6–65 years) with recurrent glioma were treated with bevacizumab. All underwent pre- and post-treatment MRI including T2- or FLAIR imaging, post-gadolinium contrast T1-weighted imaging, and DWI with b-1000 and b-4000. Response rates were evaluated by MacDonald- and by response assessment in neuro-oncology working group (RANO) criteria. We also assessed the response rate by calculating the size of high intensity areas using high b-value diffusion-weighted criteria. Prognostic factors were evaluated using Kaplan–Meier survival curves (log-rank test). Results: It was easier to identify pseudo-responses with RANO- than MacDonald criteria, however the reduction of edema by bevacizumab rendered the early diagnosis of tumor progression difficult by RANO criteria. In some patients with recurrent glioma treated with bevacizumab, high b-value diffusion-weighted criteria did, while MacDonald- and RANO criteria did not identify pseudo-responses at an early point after the start of therapy. Discussion and conclusion: High b-value DWI reflects cell density more accurately than regular b-value DWI. Our findings suggest that in patients with recurrent glioma, high b-value diffusion-weighted criteria are useful for the differentiation between pseudo- and true responses to treatment with bevacizumab

Advantages of high b-value diffusion-weighted imaging to diagnose pseudo-responses in patients with recurrent glioma after bevacizumab treatment.

Science.gov (United States)

Yamasaki, Fumiyuki; Kurisu, Kaoru; Aoki, Tomokazu; Yamanaka, Masami; Kajiwara, Yoshinori; Watanabe, Yosuke; Takayasu, Takeshi; Akiyama, Yuji; Sugiyama, Kazuhiko

2012-10-01

The diagnosis of pseudo-responses after bevacizumab treatment is difficult. Because diffusion-weighted imaging (DWI) is associated with cell density, it may facilitate the differentiation between true- and pseudo-responses. Furthermore, as high b-value DWI is even more sensitive to diffusion, it has been reported to be diagnostically useful in various clinical settings. Between September 2008 and May 2011, 10 patients (5 males, 5 females; age range 6-65 years) with recurrent glioma were treated with bevacizumab. All underwent pre- and post-treatment MRI including T2- or FLAIR imaging, post-gadolinium contrast T1-weighted imaging, and DWI with b-1000 and b-4000. Response rates were evaluated by MacDonald- and by response assessment in neuro-oncology working group (RANO) criteria. We also assessed the response rate by calculating the size of high intensity areas using high b-value diffusion-weighted criteria. Prognostic factors were evaluated using Kaplan-Meier survival curves (log-rank test). It was easier to identify pseudo-responses with RANO- than MacDonald criteria, however the reduction of edema by bevacizumab rendered the early diagnosis of tumor progression difficult by RANO criteria. In some patients with recurrent glioma treated with bevacizumab, high b-value diffusion-weighted criteria did, while MacDonald- and RANO criteria did not identify pseudo-responses at an early point after the start of therapy. High b-value DWI reflects cell density more accurately than regular b-value DWI. Our findings suggest that in patients with recurrent glioma, high b-value diffusion-weighted criteria are useful for the differentiation between pseudo- and true responses to treatment with bevacizumab. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Musical Imagination: Perception and Production, Beauty and Creativity

Science.gov (United States)

Hargreaves, David J.

2012-01-01

In our recently-published book "Musical Imaginations" (Hargreaves, Miell, & MacDonald, 2012), I suggest that the creative aspects of music "listening" have been neglected, and that putting these at the centre of musical creativity (which is usually seen as being manifested in the activities of composition, improvisation and performance) can lead…

Cine club

CERN Multimedia

Cine club

2016-01-01

Wednesday 29 June 2016 at 20:00 CERN Council Chamber Touching the Void   Directed by Kevin Macdonald UK / USA, 2003, 106 minutes The true story of two climbers and their perilous journey up the west face of Siula Grande in the Peruvian Andes in 1985. Original version English; English subtitles.

Chemical composition and nutritive value of irrigated tall fescue ...

African Journals Online (AJOL)

Chemical composition and nutritive value of irrigated tall fescue pasture for dairy cows. TJ Dugmore, KP Walsh, Sally J. Morning, CI MacDonald. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO ...

Untitled

Indian Academy of Sciences (India)

depressed arcs have been recommended (Armstrong and Burnham 1976; Macdonald. 1987) to represent the behaviour of the material. The physical origin of the behaviour such that it can be modelled by constant phase angle elements has also been sought out. (Jonscher 1977, 1983, 1990). We now present a preliminary ...

Book Review:The forgotten people: Political banishment under ...

African Journals Online (AJOL)

Book Review:The forgotten people: Political banishment under apartheid. H MacDonald. Abstract. No abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

The use of 65Zn for estimating group size of brown hyaenas Hyaena ...

African Journals Online (AJOL)

MacDonald 1983), is influenced by the quality of resources within a territory (Mills 1982). Group size is, however, difficult to determine accurately using routine methods (i.e., direct counts and mark recapture techniques) owing to the shy, elusive and nocturnal habits of brown hyaenas and the physiognomic characteristics of ...

Heavy Metals and Organic Pollutants in Sediments of Dar es ...

African Journals Online (AJOL)

The Florida criteria (MacDonald 1993) for assessment of pollution of tropical marine sediments was adopted in oredr to evaluate the extent of pollution in Dar es Salaam harbour sediments. The Florida criteria is one of the established references for sediment quality assessment. Heavy metals that had concentrations above ...

Attention and Facilitation: Converging Information versus Inadvertent Reading in Stroop Task Performance

Science.gov (United States)

Roelofs, Ardi

2010-01-01

Disagreement exists about whether color-word Stroop facilitation is caused by converging information (e.g., Cohen et al., 1990; Roelofs, 2003) or inadvertent reading (MacLeod & MacDonald, 2000). Four experiments tested between these hypotheses by examining Stroop effects on response time (RT) both within and between languages. Words cannot be…

Relational Framing Theory and Coming-Out Narratives: A Data Analysis Activity

Science.gov (United States)

Helens-Hart, Rose

2015-01-01

Coming-out scenarios have been described as potentially traumatic events that change the parent-child relationship (MacDonald, 1983). Little research in the field of communication studies has been conducted on how the process of coming out unfolds within families (Valentine, Skelton, & Butler, 2003). The exercise described in this article…

311----10 Dec 2009 [ Final version].indd

African Journals Online (AJOL)

2009-12-10

Dec 10, 2009 ... Fighting crime in the new South Africa has taken on new challenges under a ... spurred on by Gordon MacDonald's own 'renewed challenge of insisting that my life of following ... Postfoundationalism has emerged from the work of Wentzel van Huyssteen .... contribute to providing a solution in this regard.

Observer Role and Field Study Knowledge--An Essay Review of Usable Knowledge and SAFARI I.

Science.gov (United States)

Smith, Louis M.; And Others

1981-01-01

A synthesis is presented of the work of Lindblom and Cohen, MacDonald and Walker, and the current authors. The synthesis considers issues in the usefulness of social science theory and research, and how observer roles in qualitative field studies yield multiple kinds of usable knowledge to a variety of audiences. (Author/BW)

Discriminating four tectonic settings: Five new geochemical ...

Indian Academy of Sciences (India)

of basic and ultrabasic rocks from four tectonic settings of island arc, continental rift, ocean-island, and mid-ocean ridge. These diagrams were ...... 9. Macdonald et al (1995). 8. 1. 35.9. 3.7. Kenya, Turkana Rift (Bird Nest,. Central). 3 ...... reproduction in diverse applications. 4.2 Comparison of linear discriminant analysis.

Browse Title Index

African Journals Online (AJOL)

Items 501 - 550 of 900 ... C MacDonald, B Hilton, R Dove. Vol 15, No 1 (2015), Intrahousehold allocation, household headship and nutrition of under-fives: a study of western Kenya, Abstract PDF. S M Mikalitsa. Vol 12, No 5 (2012), Introducing new agricultural technologies and marketing strategies: A means for increasing ...

Should preterm labour and preterm premature rupture of ...

African Journals Online (AJOL)

Should preterm labour and preterm premature rupture of membranes be treated with antibiotics? AP Macdonald. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/ogf.v19i2.43719 · AJOL African Journals Online. HOW TO ...

The use of dexamethasone in women with preterm premature ...

African Journals Online (AJOL)

The use of dexamethasone in women with preterm premature rupture of membranes - A multicentre, double-blind, placebocontrolled, randomised trial. R.C. Pattinson, J.D. Makin, M. Funk, S.D. Delport, A.P. Macdonald, K. Norman, G. Kirsten, C. Stewart, D. Woods, G. Moller, E. Coetzee, P. Smith, J. Anthony, M. Schoon, ...

The problem of intrapartum asphyxia and birth trauma: editorial ...

African Journals Online (AJOL)

The problem of intrapartum asphyxia and birth trauma: editorial. AP Macdonald. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

Disruptive Technology for Vector Control: the Innovative Vector Control Consortium and the US Military Join Forces to Explore Transformative Insecticide Application Technology for Mosquito Control Programmes

Science.gov (United States)

2015-09-26

Jennifer Knapp1, Michael Macdonald2, David Malone3, Nicholas Hamon3 and Jason H. Richardson4* Abstract Malaria vector control technology has remained...control of Aedes albopictus in residential neighborhoods: from optimiza- tion to operation. PLoS One. 2014;9:e110035. 22. Lee VJ, Ow S, Heah H, Tan MY

Neural Stem Cell Delivery of Therapeutic Antibodies to Treat Breast Cancer Brain Metastases

Science.gov (United States)

2010-10-01

Barry AM, MacKenzie LT, Mikulis DJ, Palmieri D, Bronder JL, Steeg PS, Yoneda T, MacDonald IC, Chambers AF, Rutt BK, Foster PJ: In vivo MRI of cancer...Fransisco, CA). Caspase-3 was immunoprecipitated from cell lysates in the presence of protease inhibitors (Roche complete Mini tablet , EDTA-free and 2

Reconsidering the Summer Residence: The City-Text, Historical Commemoration and Banal Settler Geography

Science.gov (United States)

Smith, Bryan

2017-01-01

Author Bryan Smith agrees that critiques of Sir John A. Macdonald, and Cornwallis as unworthy of public commemoration are warranted and necessary, particularly as each was instrumental in cementing settler-colonial projects of dominion and erasure of Indigenous populations. However, he observes that each figure is but one point (or multiple) in…

9 CFR 147.3 - The stained-antigen, rapid, whole-blood test. 3

Science.gov (United States)

2010-01-01

...-blood test. 3 147.3 Section 147.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... Blood Testing Procedures § 147.3 The stained-antigen, rapid, whole-blood test. 3 3 The procedure described is a modification of the method reported by Schaffer, MacDonald, Hall, and Bunyea, Jour. Amer. Vet...

67,5 I

African Journals Online (AJOL)

A review on the feeding of poultry litter in South Africa was published by Bishop, Wilke, Nash, Nell, MacDonald,. Compaan, Grobler & Kingman (1971t'o'). Dehydrated poultry waste in rations for dairy cows received the atten- tion of Thomas Tinnimit & Zindel (1912), while the use of poultry litter in drought rations for weaner ...

During the British Antarctic Survey's Offshore Biological Programme ...

African Journals Online (AJOL)

spamer

high wingfold thickened to form a ridge, long wing, short crest; hood long relative to crest and broadly notched in the midline; thickened fold running to lower part ... soma (Goodrich, 1896), C. imperator Chun, 1910, C. atlantica (MacDonald & Clench, 1934), C. joubini. Voss, 1967, C. capensis Voss, 1967 and C. calyx. Young ...

Idowu et al (19).cdr

African Journals Online (AJOL)

Timothy Ademakinwa

aquifer flow (MacDonald et al., 2005). Typically, it travels vertically downwards through the unsaturated zone to the water table, from where it flows according to the hydraulic gradient, until it reaches an area of discharge where it occurs as springs or seepages, providing part of the dry season flow and constituting part of the.

Author Details

African Journals Online (AJOL)

Macdonald, CI. Vol 1, No 3 (1984) - Articles Growth patterns of Italian ryegrass cultivars established in different seasons. Abstract. ISSN: 1022-0119. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

Author Details

African Journals Online (AJOL)

Dzirutwe, MacDonald. Vol 68 (2018) - Articles The inside story of Mugabe's downfall. Abstract. ISSN: 1607-2820. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER ...

Palæomagnetism of Hawaiian lava flows

Science.gov (United States)

Doell, Richard R.; Cox, Allan

1961-01-01

PALÆOMAGNETIC investigations of volcanic rocks extruded in various parts of the world during the past several million years have generally revealed a younger sequence of lava flows magnetized nearly parallel to the field of a theoretical geocentric axial dipole, underlain by a sequence of older flows with exactly the opposite direction of remanent magnetization. A 180-degree reversal of the geomagnetic field, occurring near the middle of the Pleistocene epoch, has been inferred by many workers from such results1–3. This is a preliminary report of an investigation of 755 oriented samples collected from 152 lava flows on the island of Hawaii, selected to represent as many stratigraphic horizons as possible. (Sampling details are indicated in Table 1.) This work was undertaken because Hawaii's numerous thick sequences of lava flows, previously mapped as Pliocene to Historic by Stearns and Macdonald4, and afterwards assigned ages ranging from later Tertiary to Recent, by Macdonald and Davis5, appeared to offer an ideal opportunity to examine the most recent reversal of Earth's field.

The Ups and Downs of Cognitive Function: Neuroticism and Negative Affect Drive Performance Inconsistency.

Science.gov (United States)

Munoz, Elizabeth; Stawski, Robert S; Sliwinski, Martin J; Smyth, Joshua M; MacDonald, Stuart W S

2018-03-26

Response time inconsistency (RTI)-or trial-to-trial variability in speeded performance-is increasingly recognized as an indicator of transient lapses of attention, cognitive health status, and central nervous system integrity, as well as a potential early indicator of normal and pathological cognitive aging (Hultsch, Strauss, Hunter, & MacDonald, 2008; MacDonald, Li, & Bäckman, 2009). Comparatively, little research has examined personality predictors of RTI across adulthood. We evaluated the association between the personality trait neuroticism and RTI in a community-dwelling sample of 317 adults between the ages of 19 to 83 and tested for two indirect pathways through negative affect (NA) and cognitive interference (CI). The personality trait neuroticism predicted greater RTI independent of mean response time performance and demographic covariates; the results were age-invariant. Furthermore, NA (but not CI) accounted for this association and moderated mediation model results indicated that older adults were more vulnerable to the adverse effects of NA. Neuroticism predicts greater response time inconsistency irrespective of mean performance and this effect is driven largely by heightened negative emotionality that may be particularly detrimental for older adults.

THE ELECTORAL FAILURE OF LIBERAL PARTIES IN CENTRAL EUROPE: A DIRECTIONAL MODEL ANALYSIS

Directory of Open Access Journals (Sweden)

Alexandru VOLACU

2011-12-01

Full Text Available In this paper we provide a theoretical framework for interpreting the reiterated failure of liberal parties in a series of Central European states (namely Austria, Belgium, Germany, Luxembourg and the Netherlands. We argue that the directional model of spatial analysis elaborated by Rabinowitz and Macdonald (1989 and Macdonald, Listhaug and Rabinowitz (1991 can be an efficient instrument used for understanding why liberal parties are not able to perform as well as their opponents in elections, our hypothesis being, in consistency with the theoretical predictions made by the directional model, that political parties which ideologically diverge from the center without becoming too radical are more likely to increase their electoral percentage then parties which converge toward the ideological center. We test and partially confirm our hypothesis by comparatively studying the ideological shifts and electoral percentages of liberal parties within the 5 states mentioned above, across a period of five consecutive elections, proving that a correlation between ideological shifts and electoral percentages exists in the sense predicted by the directional model for a large majority of cases.

Transgression in the Gender Representation in MacDonald's Princess Books

Science.gov (United States)

Tso, Anna Wing Bo

2007-01-01

Recent studies have shown that under the influence of feminist theory, today one of the most popular areas of academic children's literature criticism is "the rereading of texts for previously unrevealed interpretations" (Paul, 2004: 142). By "rereading," academic feminist children's literature critics look at the ways ideological implications are…

Physical Environment of the Pacific Missile Range Facility, Kauai, Hawaii,

Science.gov (United States)

1984-03-01

Macdonald, Davis, and Cox (1960), the island of Kauai and the adjacent island of Niihau are lava domes located at the top of one large marine volcanic...tidal current. 35 z Hnalei B. ~ IV* KAUAI 220 NIIHAU MnaP N Koeno P OAHU V, 0 10 20 -3.0 Scale in Nautical Miles Approx. * LEGEND ~-FLOOD CURRENT

People and things. CERN Courier, Jan-Feb 1990, v. 30(1)

International Nuclear Information System (INIS)

Anon.

1990-01-01

The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events: A cryogenic electron beam ion source (CRYEBIS) came into operation last year at the J.R. Macdonald Laboratory, Kansas State University, and went on to supply fully stripped argonlons for physics

People and things. CERN Courier, Jan-Feb 1990, v. 30(1)

Energy Technology Data Exchange (ETDEWEB)

Anon.

1990-01-15

The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events: A cryogenic electron beam ion source (CRYEBIS) came into operation last year at the J.R. Macdonald Laboratory, Kansas State University, and went on to supply fully stripped argonlons for physics.

Author Details

African Journals Online (AJOL)

MacDonald, D. Vol 25, No 3 (2013) - Articles A review of cricket Fielding requirements. Abstract PDF. ISSN: 2078-516X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News.

Impact of divalent dopant Ca on the electrical properties of ZnO by ...

Indian Academy of Sciences (India)

[9] Barsoukov E and Macdonald J R (eds) 2005 Impedance spectroscopy: theory, experiment, and applications, 2nd edn. (New York: John Wiley & Sons Inc.) [10] Barranco A P, Pinar F C, Martinez O P, Guerra D L S and. Carmenate G 1999 J. Eur. Ceram. Soc. 19 2677. [11] Muthukumarn S and Gopalkrishan R 2012 Opt.

Untitled

Indian Academy of Sciences (India)

MacDonald J. R. Lynn KG, Boie RA and Robbins MF 1978 Nucl. Instrum. & Methods 153 189. MacKenzie IK, Khoo TL, McDonald AB and McKee BTA 1967 Phys. Rev. Lett. 19946. Nicollian E H and Brews 1982 Metal oxide superconductor, in Physics and Technology (New York: Wiley). Nielsen B, Lynn KG, Yen C Chen and ...

Book Review: "Hidden Markov Models for Time Series: An ...

African Journals Online (AJOL)

Hidden Markov Models for Time Series: An Introduction using R. by Walter Zucchini and Iain L. MacDonald. Chapman & Hall (CRC Press), 2009. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/saaj.v10i1.61717 · AJOL African Journals Online.

Witnesses to the truth: Mark's point of view

African Journals Online (AJOL)

2016-08-12

Aug 12, 2016 ... mobile device to read online. Authors: .... true identity of who this 'Jesus' is. He is Israel's ... author links the good news of God's Son to Jewish ..... As Jesus' ministry continues, his fame begins to spread (Mk. 1:45; 2:2, 12, ...... MacDonald, D.K., 2013, 'The characterisation of a false disciple: Judas Iscariot in.

Theories of Notation and Polar Motion I,

Science.gov (United States)

1980-12-01

relative motions such as ocean currents and winds, as we shall do. For the consideration of such effects see (Munk and Macdonald, 1960, p. 123; Lambeck...n)e ,uite general and niot irestricted to a solid body. In Fact, we na~it also in toe Poi ncar model . The equation K 12-1:: no;s the exponencial

Technology in the Montessori Classroom: Benefits, Hazards and Preparation for Life

Science.gov (United States)

MacDonald, Greg

2016-01-01

Greg MacDonald cites much research on the pros and cons of technology for children of all ages and gives the reader the information and space to sort out what their own policy will be. He supports the use of computers in elementary classrooms if there is a practical purpose, a group project, or no alternative approach available, such as for…

Relationship of Life Satisfaction and Job Satisfaction among Pakistani Army Soldiers

OpenAIRE

Summaira Naz

2015-01-01

The present study had two main objectives; first, to discover the relationships between job satisfaction and life satisfaction in Pakistani army soldiers, second, to find out the age, salary, marital status, and education differences on job satisfaction and life satisfaction in Pakistani army soldiers. In the present study two questionnaires; Job Satisfaction Scale JSS (Macdonald & Maclntyre, 1997) and Satisfaction With Life Scale (Diener, ...

Linnakultuuri õppetoolil kaks koostöölepingut

Index Scriptorium Estoniae

2000-01-01

20. oktoobril allkirjastasid kultuuriteaduskonna linnakultuuri õppetooli professor Raimo Pullat ja Aberdeeni ülikooli ajaloo osakonna professor I.R.Macdonald Erasmus-programmi raames kahepoolse koostöölepingu, mis näeb ette üliõpilaste ja õppejõudude vahetust. Linnakultuuri ajaloo õppetooli esimene sellelaadne koostööleping aastateks 2001-2005 sõlmiti Kieli ülikooli ajaloo osakonnaga selle aasta kevadel

Keynote address

International Nuclear Information System (INIS)

Farlinger, W.

1997-01-01

In this second keynote address of the conference Mr. Farlinger, Chairman of Ontario Hydro, attempted to respond to some of the criticisms levelled at the Corporation in the course of the Macdonald Committee process. He appeared to be particularly vexed by the criticism of IPPSO, saying that in effect, they are' beating up on their only customer', at a time when Hydro is being pulled in several different directions, and was facing pressure from jurisdictional dispute with municipal utilities, (MEUs). Nevertheless, he agreed with the need for restructuring. He defended Hydro by saying that the Macdonald Report in fact represented a vindication of the position Ontario Hydro had taken, particularly on such issues as open competition, customer choice, rationalization of the distribution system, and termination of Hydro's monopoly position. At the same time, he objected to the Report's assertion that dismantling the generation system into smaller units would be in the best interest of the people of Ontario. He suggested that there would be several large US utility companies willing and able to fill the vacuum if there was no large company with its head office in Ontario to stake its claim to the provincial market

Matching based on biological categories in Orangutans (Pongo abelii and a Gorilla (Gorilla gorilla gorilla

Directory of Open Access Journals (Sweden)

Jennifer Vonk

2013-09-01

Full Text Available Following a series of experiments in which six orangutans and one gorilla discriminated photographs of different animal species in a two-choice touch screen procedure, Vonk & MacDonald (2002 and Vonk & MacDonald (2004 concluded that orangutans, but not the gorilla, seemed to learn intermediate level category discriminations, such as primates versus non-primates, more rapidly than they learned concrete level discriminations, such as orangutans versus humans. In the current experiments, four of the same orangutans and the gorilla were presented with delayed matching-to-sample tasks in which they were rewarded for matching photos of different members of the same primate species; golden lion tamarins, Japanese macaques, and proboscis monkeys, or family; gibbons, lemurs (Experiment 1, and subsequently for matching photos of different species within the following classes: birds, reptiles, insects, mammals, and fish (Experiment 2. Members of both Great Ape species were rapidly able to match the photos at levels above chance. Orangutans matched images from both category levels spontaneously whereas the gorilla showed effects of learning to match intermediate level categories. The results show that biological knowledge is not necessary to form natural categories at both concrete and intermediate levels.

Independent Power Producers' view on restructuring in Ontario's electric power sector

International Nuclear Information System (INIS)

Brooks, J.

1996-01-01

The collective views on electricity industry restructuring of the independent power producers in Ontario were summarized by IPPSO's executive director. The Society is fully in agreement with the MacDonald Committee recommendations to privatize power generation in Ontario, and is equally in favor of competitive restructuring that is now underway in Michigan, New York and Quebec, as well as farther afield in the U.S., the U.K., and elsewhere around the world. IPPSO claims that a competitive generation system comprised of current and future IPPSO members could supply the province's power requirements at a cost 20 per cent lower than the present monopolistic system of Ontario Hydro. Add to that no reduction in services to the consumers, increased revenues in the form of taxes to the province, and the prospect of restructuring becomes far less threatening than first perceived. While fully in agreement with the MacDonald Committee's recommendations, IPPSO is opposed to Ontario Hydro's own restructuring plans. Their objection is based on the assessment that the plan would not result in real competition; in reality, it would allow Hydro even greater freedom to continue investing publicly-guaranteed money on a completely dissimilar basis to its competitors

Vaincre le vampire violet | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

26 janv. 2011 ... ... de s'assurer que l'arme fongique découverte par Alan Watson ne se transforme en mercenaire et cause la destruction d'autres espèces végétales, Fusarium oxysporum a été soumis pendant deux ans à une batterie de tests dans les laboratoires hautement sécurisés de McGill, sur le campus Macdonald.

Elliptic hypergeometric functions associated with root systems

OpenAIRE

Rosengren, Hjalmar; Warnaar, S. Ole

2017-01-01

We give a survey of elliptic hypergeometric functions associated with root systems, comprised of three main parts. The first two form in essence an annotated table of the main evaluation and transformation formulas for elliptic hypergeometric integeral and series on root systems. The third and final part gives an introduction to Rains' elliptic Macdonald-Koornwinder theory (in part also developed by Coskun and Gustafson).

A Brief Survey of the Mosquitoes of South Sulawesi, Indonesia, with Special Reference to the Identity of ’Anopheles barbirostris’ (Diptera: Culicidae) from the Margolembo Area

Science.gov (United States)

1977-06-20

mosquitoes hitherto recorded from Sulawesi and adjacent islands is presented. The prevalence of malaria and filariasis in transmigration villages of...East Indian mosquitoes. Bull. Ent. Res. 25: 501-19, illus. 1939. Notes on Dutch East- Indian mosquitoes. Tij&hr. Ent. 82: 91-113, illus. Brug, S...Macdonald, W. W. 1957. Malaysian parasites. XVI. An interim review of the non-anopheline mosquitoes of Malaya. Stud. Inst. Med. Res., Malaya 28: l-34

Problem Solving and Emotional Distress Among Brain and Breast Cancer Survivors

Science.gov (United States)

2007-03-30

with cancer and their families. Cancer, 74, 2071-2078. Lazarus , R. S., & Folkman , S. (1984). Stress, appraisal, and coping. New York: Springer...being able to access post-treatment rehabilitative care (Eversley et al., 2005). Social Problem Solving Lazarus and Folkman’s stress appraisal...International Neuropsychological Sociology, 9(7), 967-982. Archibald, Y . M., Lunn, D., Ruttan, L. A., MacDonald, D. R., Del Maestro, R. F., Barr, H

Rapid Stabilization/Polymerization of Wet Clay Soils; Literature Review

Science.gov (United States)

2009-01-15

MacDonald, W. A., Pitman, D., and Ryan, T. G. (1999). "High Tempera- ture Non-aqueous Dispersion Polymerization of Aromatic Main Chain Liquid...of Dispersive Soils by Using Different Additives." Indian Geotechnical Journal, 14(3), 202-216. 36. Charleson, D. A. and Widger, R. A. (1989...Baghdadi, Z. A., and Khan, A. M. (1991). "Overconsolidated Beha- vior of Phosphoric Acid and Lime-Stabilized Kaolin Clay." Transportation Research

Targeting youth and concerned smokers: evidence from Canadian tobacco industry documents

OpenAIRE

Pollay, R.

2000-01-01

OBJECTIVE—To provide an understanding of the targeting strategies of cigarette marketing, and the functions and importance of the advertising images chosen.
METHODS—Analysis of historical corporate documents produced by affiliates of British American Tobacco (BAT) and RJ Reynolds (RJR) in Canadian litigation challenging tobacco advertising regulation, the Tobacco Products Control Act (1987): Imperial Tobacco Limitee & RJR-Macdonald Inc c. Le Procurer General du Canada.
RESULTS—Careful and ext...

Analyzing Factors to Improve Service Quality of Local Specialties Restaurants: A Comparison with Fast Food Restaurants in Southern Vietnam

OpenAIRE

Lai Wang Wang; Thanh Tuyen Tran

2014-01-01

The top fast food restaurant brands like KFC and MacDonald?s have gone global and demonstrated their successful business strategies through providing quick-service and convenience for customers. Meanwhile, local specialty food has recently emerged as a phenomenon attracting customers? attention on traditional value of ethnic food culture. The purpose of this study is to conduct a regional survey in Vietnamese restaurant companies to identify some key factors that make customers interested in ...

Effects of Sensing Capability on Ground Platform Survivability During Ground Forces Maneuver Operations

Science.gov (United States)

2014-09-01

for his willingness to spend time providing me valuable advice on regression and partition tree analysis, and Ms. Mary Macdonald, for her... Conner 2014) TOW missiles. The BGM-71 has a shaped-charge warhead, and one of the variants, the TOW-2B Aero, has the highest engagement range of...What Does Congress Do?” Accessed July 15. http://www.congresslink.org/print_basics_congress.htm. Conners , Chris. 2014. “Cavalry Fighting Vehicle

Spectroscopic Biomarkers for Monitoring Wound Healing and Infection in Combat Wounds

Science.gov (United States)

2013-10-01

urine myoglobin) in addition to cardiac output, blood pressure, serum lactate, base deficit and hemoglobin levels before, during, and after limb...while body temperature and heart rate increase (2.5% and 20.5%, respectively). Some systemic markers such as blood urea nitrogen (Day 0 (D0)=5.0...Boursiquot R, Tomin E, Macdonald DE, Maddula S, Raghavan D, Lane JM, Helfet DL. The effects of COX-1 and COX-2 inhibitors on prostaglandin synthesis

Soleil et saris : le gage d'une eau potable sûre | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

9 juin 2016 ... S.I. Ali, M. MacDonald, J. Jincy, K.A. Sampath, G. Vinothini, L. Philip, K. Hall et K. Aronson. Des chercheurs du Canada et de l'Inde bénéficiant d'une subvention du CRDI ont découvert qu'en filtrant de l'eau polluée au moyen d'un morceau de tissu de sari et en la purifiant ensuite en l'exposant aux rayons ...

A review of continent scale hydrological datasets available for Africa

OpenAIRE

Bonsor, H.C.

2010-01-01

As rainfall becomes less reliable with predicted climate change the ability to assess the spatial and seasonal variations in groundwater availability on a large-scale (catchment and continent) is becoming increasingly important (Bates, et al. 2007; MacDonald et al. 2009). The scarcity of observed hydrological data, or difficulty in obtaining such data, within Africa means remotely sensed (RS) datasets must often be used to drive large-scale hydrological models. The different ap...

A Preliminary Investigation of Traumatically Induced Axonal Injury in a Three-Dimensional (3-D) Finite Element Model (FEM) of the Human Head During Blast-Loading

Science.gov (United States)

2013-07-01

are reconstructed from DTI data. An algorithm was previously developed by ARL to import diffusion-weighted imaging data (in this case, DTI data...this study contained ocular cavities in the facial bone, but lacked both openings on the sphenoid for the optic canals. This could potentially alter...Cellular Response. J of Trauma , 2009, 67, 1113–1122. 3. MacDonald, C., Johnson, A.; Cooper, D.; Malone, T.; Sorrell, J.; Shimony, J.; Parsons, M

Stochastic Modelling of Seafloor Morphology

Science.gov (United States)

1990-06-01

trenches, and linear island chains to the point that many of the interesting questions of marine geology now concern the processes which have shaped...are all located near the Easter Island Microplate (Figure 5.2), a region with a complex tectonic history [Hey et al., 19851, and may be anomalous...the Clipperton Transform Fault [Macdonald and Fox, 1988]. Just south of Clipperton , the ridge crest is shallow (-2550 m) and the crestal horst is broad

Ecology of Hypersaline Microorganisms

Digital Repository Service at National Institute of Oceanography (India)

Kerkar, S.

of ancient seas. Deep Sea brines are relatively stable as a result of their higher density as reported in the Red Sea and Gulf of Mexico (MacDonald et al, 1990). Preliminary studies have suggested that microbial activity occurs in some Deep Sea hypersaline... partially characterized extreme halophile called ?Halobacterium sp GN101? (GN = Guerrero Negro, Mexico) (Ebert and Goebel, 1985). Hal R1 activity is typical with first activity detected during the transition from exponential to stationary phase...

Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites

DEFF Research Database (Denmark)

Bejon, Philip; Turner, Louise; Lavstsen, Thomas

2011-01-01

Malaria transmission may be considered to be homogenous with well-mixed parasite populations (as in the classic Ross/Macdonald models). Marked fine-scale heterogeneity of transmission has been observed in the field (i.e., over a few kilometres), but there are relatively few data on the degree...... of mixing. Since the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is highly polymorphic, the host's serological responses may be used to infer exposure to parasite sub-populations....

Survival after adjuvant chemoradiotherapy or surgery alone in resectable adenocarcinoma at the gastro-esophageal junction

DEFF Research Database (Denmark)

Kofoed, Steen Christian; Muhic, A; Jensen, Lene Bæksgaard

2012-01-01

Longterm survival after curative resection for adenocarcinoma at the gastro-esophageal junction (GEJ) range between 18% and 50%. In the pivotal Intergroup-0116 Phase III trial by Macdonald et all, adjuvant chemoradiotherapy improved both disease-free and overall survival in curatively resected pa...... patients with mainly gastric adenocarcinoma. We compared survival data for curatively resected patients with adeno-carcinoma solely at the gastro-esophageal junction (GEJ), treated with surgery alone or surgery and adjuvant chemoradio-therapy....

Dynamics of the conservative and dissipative spin-orbit problem

CERN Document Server

Celletti, A; Lega, E

2006-01-01

We investigate the dynamics of the spin--orbit coupling under different settings. First we consider the conservative problem, and then we add a dissipative torque as provided by MacDonald's or Darwin's models. By means of frequency analysis and of the computation of the maximum Lyapunov indicator we explore the different dynamical behaviors associated to the main resonances. In particular we focus on the 1:1 and 3:2 resonances in which the Moon and Mercury are actually trapped.

The JASON Remotely Operated Vehicle System

Science.gov (United States)

1993-02-01

University of Rhode Island , Mote Marine Laboratory, the Harbor Branch Foundation, the Great Lake Studies Group at the University of Wisconsin, and the... Clipperton Fracture Zone to 120 N., Geo-Marine Letters. v. 8, p. 131-138. I 38. Haymon, R., Fornari, D., Edwards, M., Carbotte, S., Wright, D. and Macdonald...Science Library FRANCE University of Rhode Island Narragansett Bay Campus3 Narragansett, RI 02882 I I0272-101 REPORT DOCUMENTATIO RM N HI-33 2. 3

Oceanic Lithosphere Magnetization: Marine Magnetic Investigations of Crustal Accretion and Tectonic Processes in Mid-Ocean Ridge Environments

Science.gov (United States)

2007-09-01

9’ 25’N on the EPR, along the northern section of the ridge bounded by the Clipperton and Siqueiros Transform Faults (TF) (Fig. 2-la). As with other...and encompasses the entire segment of the EPR from the Clipperton TF to the Siqueiros TF. The Carbotte and Macdonald [ 1992] grid was continued...al. [1996], Nicolas et al. [1996]; Kelemen et al.[1997]; Le Mee et al. [2004]), Bay of Islands ophiolite (Canada) [Swift and Johnson, 1984] and

People and things. CERN Courier, Oct 1989, v. 29(8)

Energy Technology Data Exchange (ETDEWEB)

Anon.

1989-10-15

The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events. The Finnish Government has decided to begin negotiations for Finland to become a CERN Member State in a few years. A cryogenic electron beam ion source (CRYEBIS) came into operation earlier this year at the J.R. Macdonald Laboratory of the University of Kansas and went on to supply fully stripped argon ions for physics experiments.

Potential impact on climate of the exploitation of methane hydrate deposits offshore

Digital Repository Service at National Institute of Oceanography (India)

Glasby, G.P.

. Brewer (2000) has identified two examples, one in the Eel River Basin off the coast of northern California (Brooks, Field, & Kennicutt, 1991) and the other in the Gulf of Mexico (MacDonald et al., 1994), where the methane hydrate deposits lie almost... of Mexico (an example of the structural type of deposit) are potentially the most attractive deposits economically. In particular, it was considered that devel- opment costs for these deposits would be low because the accumulations are located at relatively...

Fault system and thermal regime in the vicinity of site NGHP-01-10, Krishna-Godavari basin, Bay of Bengal

Digital Repository Service at National Institute of Oceanography (India)

Dewangan, P.; Srirama, G.; Ramprasad, T.; Ramana, M.V.; Jaiswal, P.

driven (Milkov and Sassen, 2002). In structural accumulation gases are transported to the GHSZ through features such as faults and mud 3 volcanoes, e.g. northwestern Gulf of Mexico (Brooks et al., 1986; MacDonald et al., 1994; Milkov and Sassen, 2000... horizons, e.g., Blake ridge (Xu and Ruppel, 1999; Dickens et al., 1997), Gulf of Mexico minibasins (Milkov and Sassen, 2001; Pflaum et al., 1986), Nankai trough (Matsumoto et al., 2001), and Mallik (Dallimore et al., 1999). A combination of both...

People and things. CERN Courier, Oct 1989, v. 29(8)

International Nuclear Information System (INIS)

Anon.

1989-01-01

The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events. The Finnish Government has decided to begin negotiations for Finland to become a CERN Member State in a few years. A cryogenic electron beam ion source (CRYEBIS) came into operation earlier this year at the J.R. Macdonald Laboratory of the University of Kansas and went on to supply fully stripped argon ions for physics experiments

On the magneto-roton gap and the Laughlin State Stability

International Nuclear Information System (INIS)

Cabo Montes de Oca, A.

1998-07-01

It is argued that the Girvin, MacDonald and Platzman (GMP) evaluation of the magneto-roton spectrum, in spite of probably being a sensible estimate of the excitation spectrum around the real FQHE ground state, does not imply the variational stability of the Laughlin state. The supplementary corrections needed to produce a variational calculation around the ν=1/3 Laughlin state, are evaluated approximately. These preliminary results indicate the existence of lower lying states for a range of wavevector values. (author)

Summaries of Papers Presented at the High Resolution Spectroscopy Topical Meeting Held in Salt Lake City, Utah on 18-21 January 1993. Technical Digest Series. Volume 1. Postconference Edition

Science.gov (United States)

1994-05-01

National Science Foundation Presidential Young Investigator 1 Kittrel, C., Abramson, E., Kinsey, J.1., MacDonald, S.A., Reisner, D.E., Feild , R.W...in the zone B . Here the atomic beam interacts with the light fields . the wave vectors directions of which Is opposite to those of zone A , and...This tensor can be written in the following covariant form", S=XI+Cee e* +C2 e.e, where I is the unit tensor.e is the polarization vector of the pump

The Radical Thread - Liberalism and the rise of Labour in Scotland 1886 - 1924

Directory of Open Access Journals (Sweden)

Catriona MacDonald

2011-09-01

Full Text Available PreambleThis paper is a revised version of a lecture delivered to the Liberal Democrat History Meeting at the Scottish Liberal Democrat Conference in 2009. It was the subject of a report in the Journal of Liberal History (Winter 2009-2010, pp. 32-38. See also Catriona M.M. Macdonald, The Radical Thread: Political Change in Scotland, Paisley 1885-1924 (John Donald, 2000.Contemporary resonances are seductive when reflecting on the historic and recent past of the Liberal Party in Britain and i...

VizieR Online Data Catalog: Kepler-80 transit timing observations (MacDonald+, 2016)

Science.gov (United States)

MacDonald, M. G.; Ragozzine, D.; Fabrycky, D. C.; Ford, E. B.; Holman, M. J.; Isaacson, H. T.; Lissauer, J. J.; Lopez, E. D.; Mazeh, T.; Rogers, L.; Rowe, J. F.; Steffen, J. H.; Torres, G.

2017-05-01

Kepler-80 was observed photometrically by the Kepler Space Telescope. We had access to several sets of Transit Timing (TT) measurements, including the publicly available data from Rowe & Thompson (arXiv:1504.00707) and Mazeh et al. 2013 (Cat. J/ApJS/208/16). We also had the updated long-cadence TT estimates from the Mazeh group (Holczer et al. 2016, Cat. J/ApJS/225/9) and short-cadence TT data from both co-authors JR and DF. These were all measured using similar methods (see Mazeh et al. 2013, Cat. J/ApJS/208/16) and had no major differences. Spectra were taken of Kepler-80 by Keck and McDonald Observatories, and these spectra and preliminary interpretations are available on the Kepler Community Follow-up Observing Program (CFOP) website (https://cfop.ipac.caltech.edu). We acquired an 1800s high-resolution spectrum with the Keck I telescope and the High Resolution Echelle Spectrometer (HIRES) on 2011 July 20. The standard California Planet Search setup and data reduction of HIRES was used, resulting in a S/N of 35 at 5500Å. The C2 decker, with dimensions of 0.87''*14'', was used to allow a resolution of ~60000 and sky subtraction. (5 data files).

Agentive reflexive clitics and transitive 'se' constructions in Spanish

Directory of Open Access Journals (Sweden)

Grant Armstrong

2013-11-01

Full Text Available This paper investigates the structure of transitive sentences that contain a non-doubling reflexive clitic such as Juan se lavó todos los platos and María se leyó un libro. Though these are traditionally labelled unselected (non-core agreeing datives or aspectual datives, I argue that this label obscures a relevant difference between two classes of constructions. agentive reflexive clitic (= ARC constructions are characterized by a uniform set of effects on the external argument (= it must be an agent and the aspectual interpretation of the VP (= it must be an accomplishment. On the other hand, transitive se clitic (= TSC constructions do not impose any type of uniform restrictions on the kind of external argument they take or on the aspectual interpretation of the VP. I propose that the difference between these two constructions may be captured by treating se in the ARC construction as the realization of a special vDO head, based on an idea in Folli & Harley (2005, while se in the TSC construction is generated in the complement position of the verb and incorporates into V, forming a complex predicate, following work by De Cuyper (2006, MacDonald (2004, 2008 and MacDonald & Huidobro (2010. It is shown that many of the empirical and theoretical disagreements that plague the literature on the role of non-doubling se in transitive sentences have a simple solution given the new division established here

Explicit solution of the quantum three-body Calogero-Sutherland model

CERN Document Server

Perelomov, A.M.; Zaugg, P.

1998-01-01

Quantum integrable systems generalizing Calogero-Sutherland systems were introduced by Olshanetsky and Perelomov (1977). Recently, it was proved that for systems with trigonometric potential, the series in the product of two wave functions is a deformation of the Clebsch-Gordan series. This yields recursion relations for the wave functions of those systems. In this note, this approach is used to compute the explicit expressions for the three-body Calogero-Sutherland wave functions, which are the Jack polynomials. We conjecture that similar results are also valid for the more general two-parameters deformation introduced by Macdonald.

Satellite SAR inventory of Gulf of Mexico oil seeps and shallow gas hydrates

Science.gov (United States)

Garcia, O.; MacDonald, I. R.; Zimmer, B.; Shedd, W.; Frye, M.

2009-04-01

Satellite synthetic aperture radar (SAR) images from the RADARSAT platform were used to detect and inventory persistent layers of oil released from natural seeps in the Gulf of Mexico. Previously published inventories of natural oil seeps in the Gulf have been limited in scope and have relied on manual interpretation of satellite images (Mitchell et al. 1999; De Beukelaer et al. 2003). We developed a texture classifying neural network algorithm (TCNNA) to rapidly identify floating oil-layers in a semi-supervised operation. Oil layers, known as slicks, were recognized as long (10 km), narrow (100 m), often curvilinear streaks with distinct points of origin where oil reaches the ocean surface. After training the TCNNA over known seep areas and under a range of environmental and viewing conditions, the procedure was applied to 426 separate images that covered ocean areas of 100x100 km (Standard Beam Mode), 102 images that covered ocean areas of 450x450 km(ScanSAR Wide Beam Mode), and 84 images that covered ocean areas of 300x300 km (ScanSAR Narrow Beam Mode). This image data-set was collected between 1994 and 2007. It covered the entire Gulf of Mexico with a repeat rate of 4 to109, with the highest concentration over the continental slope. This effort identified a total of 4957 slicks among all the images. Of these, 287 appeared a single time in isolated locations and may therefore be false targets. The remaining slicks appeared in groups of up to 9 separate features, clustered in areas of 1 to 6.5 km across. When slicks appear within the same area in repeated images, they are judged to have a persistent source—a bubbling vent on the seafloor (MacDonald et al. 2002). Persistent sources represent geologic formations defined by migrating hydrocarbons that may include multiple separate vents. A total of 559 formations were defined by repeated imaging; these comprised a maximum of 1995 and a minimum of 1263 individual vents. This total was distributed between U

Automatic multi-modal MR tissue classification for the assessment of response to bevacizumab in patients with glioblastoma

International Nuclear Information System (INIS)

Liberman, Gilad; Louzoun, Yoram; Aizenstein, Orna; Blumenthal, Deborah T.; Bokstein, Felix; Palmon, Mika; Corn, Benjamin W.; Ben Bashat, Dafna

2013-01-01

Background: Current methods for evaluation of treatment response in glioblastoma are inaccurate, limited and time-consuming. This study aimed to develop a multi-modal MRI automatic classification method to improve accuracy and efficiency of treatment response assessment in patients with recurrent glioblastoma (GB). Materials and methods: A modification of the k-Nearest-Neighbors (kNN) classification method was developed and applied to 59 longitudinal MR data sets of 13 patients with recurrent GB undergoing bevacizumab (anti-angiogenic) therapy. Changes in the enhancing tumor volume were assessed using the proposed method and compared with Macdonald's criteria and with manual volumetric measurements. The edema-like area was further subclassified into peri- and non-peri-tumoral edema, using both the kNN method and an unsupervised method, to monitor longitudinal changes. Results: Automatic classification using the modified kNN method was applicable in all scans, even when the tumors were infiltrative with unclear borders. The enhancing tumor volume obtained using the automatic method was highly correlated with manual measurements (N = 33, r = 0.96, p < 0.0001), while standard radiographic assessment based on Macdonald's criteria matched manual delineation and automatic results in only 68% of cases. A graded pattern of tumor infiltration within the edema-like area was revealed by both automatic methods, showing high agreement. All classification results were confirmed by a senior neuro-radiologist and validated using MR spectroscopy. Conclusion: This study emphasizes the important role of automatic tools based on a multi-modal view of the tissue in monitoring therapy response in patients with high grade gliomas specifically under anti-angiogenic therapy

The Radius and Entropy of a Magnetized, Rotating, Fully Convective Star: Analysis with Depth-dependent Mixing Length Theories

Science.gov (United States)

Ireland, Lewis G.; Browning, Matthew K.

2018-04-01

Some low-mass stars appear to have larger radii than predicted by standard 1D structure models; prior work has suggested that inefficient convective heat transport, due to rotation and/or magnetism, may ultimately be responsible. We examine this issue using 1D stellar models constructed using Modules for Experiments in Stellar Astrophysics (MESA). First, we consider standard models that do not explicitly include rotational/magnetic effects, with convective inhibition modeled by decreasing a depth-independent mixing length theory (MLT) parameter α MLT. We provide formulae linking changes in α MLT to changes in the interior specific entropy, and hence to the stellar radius. Next, we modify the MLT formulation in MESA to mimic explicitly the influence of rotation and magnetism, using formulations suggested by Stevenson and MacDonald & Mullan, respectively. We find rapid rotation in these models has a negligible impact on stellar structure, primarily because a star’s adiabat, and hence its radius, is predominantly affected by layers near the surface; convection is rapid and largely uninfluenced by rotation there. Magnetic fields, if they influenced convective transport in the manner described by MacDonald & Mullan, could lead to more noticeable radius inflation. Finally, we show that these non-standard effects on stellar structure can be fabricated using a depth-dependent α MLT: a non-magnetic, non-rotating model can be produced that is virtually indistinguishable from one that explicitly parameterizes rotation and/or magnetism using the two formulations above. We provide formulae linking the radially variable α MLT to these putative MLT reformulations.

Outstanding Student Paper Awards

Science.gov (United States)

2004-04-01

The following members in the Space Physics & Aeronomy Section received Outstanding Student Paper Awards at the 2003 AGU Fall Meeting in San Francisco, California. Arve Aksnes; Aroh Barjatya; Jacob Bortnik; Amir Caspi; Ruben Delgado; Galen Fowler; Paul G. Hanlon; Sid Henderson; Tara B. Hiebert; Chia-Lin Huang; Steven P. Joy; Eun-Hwa Kim; Colby Lemon; Yingjuan Ma; Elizabeth A. MacDonald; Jaco Minnie; Mitsuo Oka; Yoshitaka Okazaki; Erin J. Rigler; Ina P. Robertson; Patrick A. Roddy; Sang-Il Roh; Albert Y. Shih; Christopher Smithtro; Emma Spanswick; Maria Spasojevic; Hiroki Tanaka; Linghua Wang; Deirdre E. Wendel; Jichun Zhang>

Unity is strength: staff college and the British officer corps.

Science.gov (United States)

King, Anthony

2009-03-01

Utilizing Bourdieu's concept of the habitus, Keith Macdonald has recently examined the elite social origins of the British officer corps. His analysis is valid as far at it goes but it ignores the professional practices of British officers. This article examines Britain's Joint Services Command and Staff College to assess the unification of the three services around common forms of military practice. It argues that while the new staff college has been effective in disseminating new forms of professional expertise among British officers, various practices have been institutionalized which actively undermine the unity of the officer corps.

Treatment of newly diagnosed glioblastoma multiforme with carmustine, cisplatin and etoposide followed by radiotherapy. A phase II study

DEFF Research Database (Denmark)

Lassen, U; Kristjansen, P E; Wagner, A

1999-01-01

fractions. Twenty-nine patients with newly diagnosed glioblastoma multiforme (GBM), mean age 50 (27-66) and performance status (PS) 0-2 were included. Using the Macdonald criteria 33% had partial remission (PR), 41% stable disease (SD) and 26% progressive disease (PD) after chemotherapy. After additional...... (6.0-9.1) and median survival was 11.4 months (10.1-12.7). We conclude that this regimen is effective and feasible in patients with GBM. The short course pre-irradiatory chemotherapy may be less cumbersome than adjuvant chemotherapy and the regimen may be even more active in grade III gliomas....

On characteristic polynomials for a generalized chiral random matrix ensemble with a source

Science.gov (United States)

Fyodorov, Yan V.; Grela, Jacek; Strahov, Eugene

2018-04-01

We evaluate averages involving characteristic polynomials, inverse characteristic polynomials and ratios of characteristic polynomials for a N× N random matrix taken from a L-deformed chiral Gaussian Unitary Ensemble with an external source Ω. Relation to a recently studied statistics of bi-orthogonal eigenvectors in the complex Ginibre ensemble, see Fyodorov (2017 arXiv:1710.04699), is briefly discussed as a motivation to study asymptotics of these objects in the case of external source proportional to the identity matrix. In particular, for an associated complex bulk/chiral edge scaling regime we retrieve the kernel related to Bessel/Macdonald functions.

“Orphan” γ-Ray Flares and Stationary Sheaths of Blazar Jets

Science.gov (United States)

MacDonald, Nicholas R.; Jorstad, Svetlana G.; Marscher, Alan P.

2017-11-01

Blazars exhibit flares across the entire electromagnetic spectrum. Many γ-ray flares are highly correlated with flares detected at longer wavelengths; however, a small subset appears to occur in isolation, with little or no correlated variability at longer wavelengths. These “orphan” γ-ray flares challenge current models of blazar variability, most of which are unable to reproduce this type of behavior. MacDonald et al. have developed the Ring of Fire model to explain the origin of orphan γ-ray flares from within blazar jets. In this model, electrons contained within a blob of plasma moving relativistically along the spine of the jet inverse-Compton scatter synchrotron photons emanating off of a ring of shocked sheath plasma that enshrouds the jet spine. As the blob propagates through the ring, the scattering of the ring photons by the blob electrons creates an orphan γ-ray flare. This model was successfully applied to modeling a prominent orphan γ-ray flare observed in the blazar PKS 1510-089. To further support the plausibility of this model, MacDonald et al. presented a stacked radio map of PKS 1510-089 containing the polarimetric signature of a sheath of plasma surrounding the spine of the jet. In this paper, we extend our modeling and stacking techniques to a larger sample of blazars: 3C 273, 4C 71.01, 3C 279, 1055+018, CTA 102, and 3C 345, the majority of which have exhibited orphan γ-ray flares. We find that the model can successfully reproduce these flares, while our stacked maps reveal the existence of jet sheaths within these blazars.

Beginning ASP.NET 4.5 in C#

CERN Document Server

MacDonald, Matthew

2012-01-01

This book is the most comprehensive and up to date introduction to ASP.NET ever written. Focussing solely on C#, with no code samples duplicated in other languages, award winning author Matthew MacDonald introduces you to the very latest thinking and best practices for the ASP.NET 4.5 technology.Assuming no prior coding experience, you'll be taught everything you need to know from the ground up.  Starting from first principals, you'll learn the skills you need to be an effective ASP.NET developer who is ready to progress to more sophisticated projects and professional work. You'll be taught ho

BKP and projective Hurwitz numbers

Science.gov (United States)

Natanzon, Sergey M.; Orlov, Aleksandr Yu.

2017-06-01

We consider d-fold branched coverings of the projective plane RP^2 and show that the hypergeometric tau function of the BKP hierarchy of Kac and van de Leur is the generating function for weighted sums of the related Hurwitz numbers. In particular, we get the RP^2 analogues of the CP^1 generating functions proposed by Okounkov and by Goulden and Jackson. Other examples are Hurwitz numbers weighted by the Hall-Littlewood and by the Macdonald polynomials. We also consider integrals of tau functions which generate Hurwitz numbers related to base surfaces with arbitrary Euler characteristics sc {e}, in particular projective Hurwitz numbers sc {e}=1.

Pro ASP.NET 4 in VB 2010

CERN Document Server

MacDonald, Matthew; Freeman, Adam; Szpuszta, Mario; Agarwal, Vidya Vrat

2010-01-01

ASP.NET 4 is the latest version of Microsoft's revolutionary ASP.NET technology. It is the principal standard for creating dynamic web pages on the Windows platform. Pro ASP.NET 4 in VB 2010 raises the bar for high-quality, practical advice on learning and deploying Microsoft's dynamic web solution. This new edition is updated with everything you need to come to grips with the latest version of ASP.NET, including coverage of ASP.NET MVC, ASP.NET AJAX 4, ASP.NET Dynamic Data, and Silverlight 3. Seasoned .NET professionals Matthew MacDonald and Mario Szpuszta explain how you can get the most fro

HYPOTHÈSES SUR L'ORIGINE DES BRUITS DU CŒUR ET DES ACCIDENTS DE DÉCOMPRESSION EN PLONGÉE : LA CAVITATION. HYPOTHÈSE SUR L'ORIGINE DE LA FERMETURE DES VALVES CARDIAQUES : LE PHÉNOMÈNE DE VENTOUSE.

OpenAIRE

Venet , Richard ,; Pavie , Alain; Leger , Philippe

2012-01-01

Nous avons proposé, dans un travail antérieur, l'hypothèse d'un phénomène de cavitation à l'origine des bruits de Korotkoff. Encouragés par l'aphorisme de MacDonald comme quoi le phénomène de cavitation est plus fréquent qu'on peut le penser dans le système cardio-vasculaire, nous avons appliqué la théorie de Womersley aux enregistrements hémodynamiques exposés dans la littérature médicale. L'enregistrement simultané des pressions du ventricule gauche (PVG), de l'aorte (PAo) et de l'oreillett...

HYPOTHÈSES SUR L'ORIGINE DES BRUITS DU CŒUR ET DES ACCIDENTS DE DÉCOMPRESSION EN PLONGÉE : LA CAVITATION. HYPOTHÈSE SUR L'ORIGINE DE LA FERMETURE DES VALVES CARDIAQUES : LE RETARD A LA FERMETURE DES VALVES (COUP DE CLAPET) ET LE PHÉNOMÈNE DE VENTOUSE.

OpenAIRE

Venet , Richard ,

2012-01-01

Nous avons proposé, dans un travail antérieur, l'hypothèse d'un phénomène de cavitation à l'origine des bruits de Korotkoff. Encouragés par l'aphorisme de MacDonald comme quoi le phénomène de cavitation est plus fréquent qu'on peut le penser dans le système cardio-vasculaire, nous avons appliqué la théorie de Womersley aux enregistrements hémodynamiques exposés dans la littérature médicale. L'enregistrement simultané des pressions du ventricule gauche (PVG), de l'aorte (PAo) et de l'oreillett...

HYPOTHÈSES SUR L'ORIGINE DES BRUITS DU COEUR ET DES ACCIDENTS DE DÉCOMPRESSION EN PLONGÉE : LA CAVITATION

OpenAIRE

Venet , Richard

2007-01-01

Nous avons proposé, dans un travail antérieur, l'hypothèse d'un phénomène de cavitation à l'origine des bruits de Korotkoff. Encouragés par l'aphorisme de MacDonald comme quoi le phénomène de cavitation est plus fréquent qu'on peut le penser dans le système cardio-vasculaire, nous avons appliqué la théorie de Womersley aux enregistrements hémodynamiques exposés dans la littérature médicale. L'enregistrement simultané des pressions du ventricule gauche (PVG), de l'aorte (PAo) et de l'oreillett...

Syntactic Complexity Effects in Sentence Production: A Reply to MacDonald, Montag, and Gennari (2016)

Science.gov (United States)

Scontras, Gregory; Badecker, William; Fedorenko, Evelina

2017-01-01

In our article, "Syntactic complexity effects in sentence production" [Scontras, Badecker, Shank, Lim, & Fedorenko, 2015 (EJ1057757)], we reported two elicited production experiments and argued that there is a cost associated with planning and uttering syntactically complex, object-extracted structures that contain a non-local…

Pobeda s pomoshtshju opija v Afganistane / Raymond Kendall, Norine MacDonald ; tõlk. Jevgenija Unanjants

Index Scriptorium Estoniae

Kendall, Raymond

2007-01-01

Autorid on seisukohal, et oopiumi hävitamine Afganistanis ei too probleemile lahendust. Oopiumi litsentseeritud tootmine ei võimaldaks lahendada mitte üksnes vaesuse ja nälja probleemi riigi lõunaosas, vaid ka stabiliseeriks kohalikke struktuure

The retail market : a consumer perspective

International Nuclear Information System (INIS)

Girvan, J.

2002-01-01

A consumer's perspective of the Ontario open retail electricity market was presented. The author, who believes the retail market in Ontario is flawed, presents some key decisions that were made regarding open competition, that may have been done differently or which have helped the market move forward. It was noted that the 1996 report by the Macdonald Committee clearly recommended that retail competition should be phased in only after the wholesale market was in place. That report also cautioned about the risks of proceeding with an open retail market without being properly prepared. The Ontario government rejected the recommendations of the Macdonald Committee and chose to open both wholesale and retail markets at the same time. Another important decision by the Ontario Energy Board was to determine that Standard Supply Service customers would be billed on the basis of a spot price pass-through model. It was noted that the lack of understanding by consumers regarding the new market and the absence of a comprehensive education campaign gave retailers an opportunity to deceive some customers. Allowing retailing prior to the introduction of unbundled bills has also led to the current state of customer confusion. Although the government has now made communication efforts, it is believed that these efforts must be greater in assuring that local distribution companies are providing what is necessary to understand the new billing format. The government has introduced Bill 58, a new legislation that includes a Customer Bill of Rights. Although this is a good initiative, it does not help the thousands of people who were misled and locked into long-term contracts. It was recommended that immediate action must be taken in the retail sector to maintain customer confidence

Biodiversity can help prevent malaria outbreaks in tropical forests.

Directory of Open Access Journals (Sweden)

Gabriel Zorello Laporta

Full Text Available BACKGROUND: Plasmodium vivax is a widely distributed, neglected parasite that can cause malaria and death in tropical areas. It is associated with an estimated 80-300 million cases of malaria worldwide. Brazilian tropical rain forests encompass host- and vector-rich communities, in which two hypothetical mechanisms could play a role in the dynamics of malaria transmission. The first mechanism is the dilution effect caused by presence of wild warm-blooded animals, which can act as dead-end hosts to Plasmodium parasites. The second is diffuse mosquito vector competition, in which vector and non-vector mosquito species compete for blood feeding upon a defensive host. Considering that the World Health Organization Malaria Eradication Research Agenda calls for novel strategies to eliminate malaria transmission locally, we used mathematical modeling to assess those two mechanisms in a pristine tropical rain forest, where the primary vector is present but malaria is absent. METHODOLOGY/PRINCIPAL FINDINGS: The Ross-Macdonald model and a biodiversity-oriented model were parameterized using newly collected data and data from the literature. The basic reproduction number ([Formula: see text] estimated employing Ross-Macdonald model indicated that malaria cases occur in the study location. However, no malaria cases have been reported since 1980. In contrast, the biodiversity-oriented model corroborated the absence of malaria transmission. In addition, the diffuse competition mechanism was negatively correlated with the risk of malaria transmission, which suggests a protective effect provided by the forest ecosystem. There is a non-linear, unimodal correlation between the mechanism of dead-end transmission of parasites and the risk of malaria transmission, suggesting a protective effect only under certain circumstances (e.g., a high abundance of wild warm-blooded animals. CONCLUSIONS/SIGNIFICANCE: To achieve biological conservation and to eliminate

Paleomagnetism of the Neoproterozoic Mount Harper Volcanic Complex, Canada

Science.gov (United States)

Eyster, A. E.; Macdonald, F. A.; O'Connell, R. J.

2012-12-01

Paleomagnetism can be used to identify apparent polar wander, which involves contributions from plate tectonics and true polar wander. True polar wander events have been suggested to have played an important role throughout Earth's history. The Neoproterozoic Mount Harper Volcanic Complex (MHVC) provides paleomagnetic data that bears on this issue. The MHVC is located in the southern Ogilvie Mountains in the Yukon Territory, on the north-west corner of the Laurentian craton. The MHVC involves up to 1200 m of basaltic and andesitic flows. The MHVC reflects the propagating rifting event involved in the breakup of the supercontinent Rodinia. The MHVC is well dated with an age of 717.43± 0.14Ma from the top (Macdonald et al., Science, 2010). Below the MHVC are alluvial fan conglomerate and sandstone from Proterozoic normal faulting. Above the MHVC is a glacial diamictite dated to 716.47± 0.24 Ma and related to Snowball Earth glaciation (Macdonald et al., Science, 2010). Both block and core samples were collected from different members of the MHVC for paleomagnetic study. Included in the sampling were several stratigraphic sections. Alternating field and thermal stepwise demagnetization methods were used to analyze specimens. Magnetic components were determined using principal component analysis and Fisher statistical procedures were used to calculate mean directions. The stratigraphically sampled basalt flows yielded two components. One was a common secondary overprint, and the other was a high stability component which yielded two different directions. One pole is the same as the accepted Neoproterozoic Laurentian grand mean pole and the other is ˜50 degrees away from this grand mean pole. Several possible interpretations are explored- tectonic rotation, true polar wander or the presence of a non-dipolar geomagnetic field.

The effects of reverberant self- and overlap-masking on speech recognition in cochlear implant listeners.

Science.gov (United States)

Desmond, Jill M; Collins, Leslie M; Throckmorton, Chandra S

2014-06-01

Many cochlear implant (CI) listeners experience decreased speech recognition in reverberant environments [Kokkinakis et al., J. Acoust. Soc. Am. 129(5), 3221-3232 (2011)], which may be caused by a combination of self- and overlap-masking [Bolt and MacDonald, J. Acoust. Soc. Am. 21(6), 577-580 (1949)]. Determining the extent to which these effects decrease speech recognition for CI listeners may influence reverberation mitigation algorithms. This study compared speech recognition with ideal self-masking mitigation, with ideal overlap-masking mitigation, and with no mitigation. Under these conditions, mitigating either self- or overlap-masking resulted in significant improvements in speech recognition for both normal hearing subjects utilizing an acoustic model and for CI listeners using their own devices.

Centerband-only-detection-of-exchange (31)P nuclear magnetic resonance and phospholipid lateral diffusion: theory, simulation and experiment.

Science.gov (United States)

Lai, Angel; Saleem, Qasim; Macdonald, Peter M

2015-10-14

Centerband-only-detection-of-exchange (CODEX) (31)P NMR lateral diffusion measurements were performed on dimyristoylphosphatidylcholine (DMPC) assembled into large unilamellar spherical vesicles. Optimization of sample and NMR acquisition conditions provided significant sensitivity enhancements relative to an earlier first report (Q. Saleem, A. Lai, H. Morales, and P. M. Macdonald, Chem. Phys. Lipids, 2012, 165, 721). An analytical description was developed that permitted the extraction of lateral diffusion coefficients from CODEX data, based on a Gaussian-diffusion-on-a-sphere model (A. Ghosh, J. Samuel, and S. Sinha, Europhys. Lett., 2012, 98, 30003-p1) as relevant to CODEX (31)P NMR measurements on a population of spherical unilamellar phospholipid bilayer vesicles displaying a distribution of vesicle radii.

Measurements on irradiated L1 sensor prototypes for the D0 Run IIb silicon detector project

International Nuclear Information System (INIS)

Ahsan, M.; Bolton, T.; Carnes, K.; Demarteau, M.; Demina, R.; Gray, T.; Korjenevski, S.; Lehner, F.; Lipton, R.; Mao, H.S.; McCarthy, R.

2010-01-01

We report on irradiation studies of Hamamatsu prototype silicon microstrip detectors for layer 1 of the D0 upgrade project for Run IIb. The irradiation was carried out with 10 MeV protons up to proton fluence of 10 14 p/cm 2 at the J.R. Macdonald Laboratory, Manhatten, KS. The flux calibration was carefully checked using different dose normalization techniques. The results based on the obtained sensor leakage currents after irradiation show that the NIEL scaling hypothesis for low energy protons has to be applied with great care. We observe 30-40% less radiation damage in silicon for 10 MeV proton exposure than is expected from the predicted NIEL scaling.

The promise of an interactive, online curriculum in improving the competence of those working in healthcare settings to address sexual assault

Directory of Open Access Journals (Sweden)

Du Mont J

2017-11-01

Full Text Available Janice Du Mont,1,2 Daisy Kosa,3 Sheila Macdonald,3 Robin Mason1,21Women’s College Research Institute, Women’s College Hospital, 2Dalla Lana School of Public Health, University of Toronto, 3Ontario Network of Sexual Assault/Domestic Violence Treatment Centres, Toronto, ON, CanadaHealthcare providers and trainees often lack the requisite knowledge and skills to address sexual violence in the clinical setting.1–3 To address this gap, we developed and evaluated an innovative and evidence-informed online curriculum designed to improve the competence of those working in healthcare settings to respond to the needs of women who present with past histories of sexual assault.

Measurements on irradiated L1 sensor prototypes for the D0 Run IIb silicon detector project

Energy Technology Data Exchange (ETDEWEB)

Ahsan, M.; Bolton, T.; Carnes, K.; /Kansas State U.; Demarteau, M.; /Fermilab; Demina, R.; /Rochester U.; Gray, T.; /Kansas State U.; Korjenevski, S.; /Rochester U.; Lehner, F.; /Zurich U.; Lipton, R.; Mao, H.S.; /Fermilab; McCarthy, R.; /SUNY, Stony Brook /Kansas State U. /Fermilab

2010-01-01

We report on irradiation studies of Hamamatsu prototype silicon microstrip detectors for layer 1 of the D0 upgrade project for Run IIb. The irradiation was carried out with 10 MeV protons up to proton fluence of 10{sup 14} p/cm{sup 2} at the J.R. Macdonald Laboratory, Manhatten, KS. The flux calibration was carefully checked using different dose normalization techniques. The results based on the obtained sensor leakage currents after irradiation show that the NIEL scaling hypothesis for low energy protons has to be applied with great care. We observe 30-40% less radiation damage in silicon for 10 MeV proton exposure than is expected from the predicted NIEL scaling.

Sex, Receptors and Attachment: A Review of Individual Factors Influencing Response to Oxytocin

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Kai S Macdonald

2013-01-01

Full Text Available As discussed in the larger review in this special issue (MacDonald and Feifel, intranasal oxytocin (IN OT is demonstrating a growing potential as a therapeutic agent in psychiatry. Importantly, research suggests that a variety of individual factors may influence a person’s response to OT. In this mini-review, I provides a review of three: (1 sex and hormonal status; (2 genetic variation in aspects of the OT system (i.e. OT receptors; and (3 attachment history. Each of these factors will be important to monitor as we strive to develop a richer understanding of OT's role in human development, brain-based disease, and the potential for individualized, OT-targeted treatments.

An Angus/Argo study of the neovolcanic zone along the East Pacific rise from the Clipperton fracture zone to 12°N

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Uchupi, E.; Schwab, W. C.; Ballard, R. D.; Cheminee, J. L.; Francheteau, J.; Hekinian, R.; Blackman, D. K.; Sigurdsson, H.

1988-09-01

Still photographs and video images collected along the Neovolcanic Zone of the East Pacific Rise from 10°15'N to 11°53'N show that recent volcanic sheet flows, possibly less than 100 years old, are superimposed on an older sediment-laden pillow terrane. This recent activity is restricted to a narrow zone that crosses two topographic highs at 10°55'N and 11°26'N and diminishes along-axis away from these highs. The association of recent sheet flows with older flows and collapse structures on the overlapping spreading centers at 11°45'N supports the evolutionary model for the occurrence and evolution of overlapping spreading centers by MacDonald and others (1986, 1988).

An Angus/Argo study of the neovolcanic zone along the East Pacific rise from the Clipperton fracture zone to 12°N

Science.gov (United States)

Uchupi, E.; Schwab, W.C.; Ballard, Richard D.; Cheminee, J.L.; Francheteau, Jean; Hekinian, R.; Blackman, D.K.; Sigurdsson, Haraldur

1988-01-01

Still photographs and video images collected along the Neovolcanic Zone of the East Pacific Rise from 10°15′N to 11°53′N show that recent volcanic sheet flows, possibly less than 100 years old, are superimposed on an older sediment-laden pillow terrane. This recent activity is restricted to a narrow zone that crosses two topographic highs at 10°55′N and 11°26′N and diminishes along-axis away from these highs. The association of recent sheet flows with older flows and collapse structures on the overlapping spreading centers at 11°45′N supports the evolutionary model for the occurrence and evolution of overlapping spreading centers by MacDonald and others (1986, 1988).

Elliptic Determinantal Processes and Elliptic Dyson Models

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Katori, Makoto

2017-10-01

We introduce seven families of stochastic systems of interacting particles in one-dimension corresponding to the seven families of irreducible reduced affine root systems. We prove that they are determinantal in the sense that all spatio-temporal correlation functions are given by determinants controlled by a single function called the spatio-temporal correlation kernel. For the four families {A}_{N-1}, {B}_N, {C}_N and {D}_N, we identify the systems of stochastic differential equations solved by these determinantal processes, which will be regarded as the elliptic extensions of the Dyson model. Here we use the notion of martingales in probability theory and the elliptic determinant evaluations of the Macdonald denominators of irreducible reduced affine root systems given by Rosengren and Schlosser.

Test of an Hypothesis of Magnetization, Tilt and Flow in an Hypabyssal Intrusion, Colombian Andes

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Muggleton, S.; MacDonald, W. D.; Estrada, J. J.; Sierra, G. M.

2002-05-01

Magnetic remanence in the Miocene Clavijo intrusion in the Cauca Valley, adjacent to the Cordillera Central, plunges steeply northward (MacDonald et al., 1996). Assuming magnetization in a normal magnetic field, the expected remanence direction is approximately I= 10o, D= 000o; the observed remanence is I=84o, D=003o. The discrepancy could be explained by a 74o rotation about a horizontal E-W axis, i.e., about an axis normal to the nearby N-S trending Romeral fault zone. If the intrusion is the shallow feeder of a now-eroded andesitic volcano, then perhaps the paleovertical direction is preserved in flow lineations and provides a test of the tilt/rotation of the remanence. In combination, the steep remanence direction, vertical flow, and the inferred rotation of the volcanic neck lead to the hypothesis of a shallow-plunging southward lineation for this body. Using anisotropy of magnetic susceptibility (AMS) as a proxy for the flow lineation, it is predicted that the K1 (maximum susceptibility) axis in this body plunges gently south. This hypothesis was tested using approximately 50 oriented cores from 5 sites near the west margin of the Clavijo intrusion. The results suggest a NW plunging lineation, inconsistent with the initial hypothesis. However, a relatively consistent flow lineation is suggested by the K1 axes. If this flow axis represents paleovertical, it suggests moderate tilting of the Clavijo body towards the southeast. The results are encouraging enough to suggest that AMS may be useful for determining paleo-vertical in shallow volcanic necks and hypabyssal intrusions, and might ultimately be useful in a tilt-correction for such bodies. Other implications of the results will be discussed. MacDonald, WD, Estrada, JJ, Sierra, GM, Gonzalez, H, 1996, Late Cenozoic tectonics and paleomagnetism of North Cauca Basin intrusions, Colombian Andes: Dual rotation modes: Tectonophysics, v 261, p. 277-289.

Benefit with methylprednisolone in continuous pulsetherapy in progressive primary form of multiple sclerosis: study of 11 cases in 11 years Benefício do uso de pulsoterapia contínua com metilprednisolona na forma primária progressiva da esclerose múltipla: estudo de 11 casos em 11 anos

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Edmar A.S. de Araújo

2008-06-01

Full Text Available Primary progressive multiple sclerosis (PPMS is defined clinically with a progressive course from onset. There is no approved treatment for the PPMS. Methylprednisolone IV (MP hastens the recovery from MS relapses. We studied 11 patients that met the MacDonald's diagnostic criteria for PPMS. The dose of MP was 30 mg/kg in 250 mL of glucose solution in three consecutive days during the first week, two doses during the second and one dose in the third week. One weekly session for eight consecutive weeks was given. After, a once-a week/eight-week interval was maintained. The medium EDSS before treatment was 6.2, and after 11.2 years of treatment, the EDSS was 4.9. Although we studied a small sample of PPMS we may conclude that therapy with IVMP prevents clinical worsening of MS in the majority of patients with improvement in EDSS scores.A forma progressiva da esclerose múltipla (FPEM é definida como progressiva desde o início. Não há tratamento eficaz para esta forma. A metilprednisolona por via endovenosa (MPEV é usada para os surtos de exacerbação da EM. Estudamos 11 pacientes que preenchiam os critérios de MacDonald para FPMS. A dose inicial de MPEV foi de 30 mg/kg em 250 mL de soro glicosado por três dias consecutivos na primeira semana, duas doses na segunda e uma dose na terceira semana. Seguiu-se uma sessão semanal por oito semanas. Após manteve-se uma dose semanal a cada oito semanas. A média do EDDS foi 9,6 antes e 4,9 após 11,2 anos de tratamento. Embora tenhamos estudado número reduzido de casos, podemos dizer que o uso de MPEV impede a progressão da FPEM na maioria dos pacientes estudados com melhora do EDDS.

The effects of different nutritional measurements on delayed wound healing after hip fracture in the elderly.

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Guo, Jiong Jiong; Yang, Huilin; Qian, Haixin; Huang, Lixin; Guo, Zhongxing; Tang, Tiansi

2010-03-01

It has been well recognized that malnutrition causes wounds to heal inadequately and incompletely. Malnutrition is often observed in the elderly, and it appears to be more severe in patients with hip fracture than in the general aging population. Few prospective studies give a detailed account of the identification and classification of nutritional status in the elderly. The objective of this study was to evaluate the effects of different nutritional measurements on wound healing status after hip fracture in the elderly. From September 2002 to December 2007, 207 hip fracture patients older than 60 y treated surgically were reviewed for preoperative nutritional status. There were 81 males and 126 females with an average age of 75.93 y (62-91 y); 131 cases with femoral neck fractures, 76 cases with intertrochanteric fractures. Parameters indicative of nutritional status (serum albumin, serum transferrin, serum pre-albumin, and total lymphocyte count levels) at the time of admission were assessed, along with anthropometric measurements, Rainey MacDonald nutritional index, and MNA tool. Suture removal was performed on postoperative day 14. Delayed wound healing complicated 46 (22.2%) of the 207 cases. The preoperative serum transferring total lymphocyte count levels, MNA total score, and Rainey MacDonald nutritional index were significantly lower for patients who subsequently had delayed wound healing. When all variables were subjected to multivariate analysis, only total lymphocyte count levels and MNA total score showed significant value in predicting which patients would have delayed wound healing. Through prophylactic antibiotics and adherence to strict aseptic precautions, on follow-up, wound healing was normal in all patients. Patients at risk for delayed wound healing problems after hip fracture can be identified using relatively inexpensive laboratory test such as TLC and MNA tool. The clinician must be aware of the risk values of both measurements. We believe

Primary ovarian insufficiency: an update

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Cox L

2014-02-01

Full Text Available Leticia Cox, James H LiuUH Case Medical Center, MacDonald Women's Hospital, Department of Obstetrics and Gynecology, Case Western Reserve University School of Medicine, Department of Reproductive Biology, Cleveland, OH, USAAbstract: Primary ovarian insufficiency is a condition that represents impaired ovarian function on a continuum with intermittent ovulation. This condition commonly leads to premature menopause, defined as cessation of ovulation prior to the age of 40 years. Because there are potential immediate and long-term consequences of hypoestrogenism, a timely diagnosis is invaluable. This comprehensive review will discuss identifiable causes for primary ovarian insufficiency, including genetic disorders and metabolic abnormalities, as well as review current strategies for diagnosis, evaluation, and management of women with this condition.Keywords: premature ovarian failure, premature menopause, ovarian dysfunction

ABCD of Beta Ensembles and Topological Strings

CERN Document Server

Krefl, Daniel

2012-01-01

We study beta-ensembles with Bn, Cn, and Dn eigenvalue measure and their relation with refined topological strings. Our results generalize the familiar connections between local topological strings and matrix models leading to An measure, and illustrate that all those classical eigenvalue ensembles, and their topological string counterparts, are related one to another via various deformations and specializations, quantum shifts and discrete quotients. We review the solution of the Gaussian models via Macdonald identities, and interpret them as conifold theories. The interpolation between the various models is plainly apparent in this case. For general polynomial potential, we calculate the partition function in the multi-cut phase in a perturbative fashion, beyond tree-level in the large-N limit. The relation to refined topological string orientifolds on the corresponding local geometry is discussed along the way.

Irinotecan and bevacizumab in recurrent glioblastoma multiforme

DEFF Research Database (Denmark)

Jakobsen, Jan Nyrop; Hasselbalch, Benedikte; Stockhausen, Marie-Thérése

2011-01-01

treatment with BVZ and irinotecan provides impressive response rates (RR), it is still uncertain if this treatment translates into improved clinical benefit in GBM patients. AREAS COVERED: This review discusses the clinical efficacy, safety and difficulties regarding response evaluation when treating...... with BVZ and CPT-11 in recurrent GBM. Particular attention is placed on the literature and a discussion on whether treatment with BVZ and CPT-11 improves clinical outcome. Antiangiogenic treatment has led to difficulties when evaluating objective response by the conventional MacDonald criteria....... In the present paper the authors discuss selected key aspects of this treatment modality. A literature search was performed using PubMed in February 2011. EXPERT OPINION: BVZ + irinotecan leads to high RR and to an increased 6-month progression-free survival. However, no improvement in median overall survival...

Multiplicative quiver varieties and generalised Ruijsenaars-Schneider models

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Chalykh, Oleg; Fairon, Maxime

2017-11-01

We study some classical integrable systems naturally associated with multiplicative quiver varieties for the (extended) cyclic quiver with m vertices. The phase space of our integrable systems is obtained by quasi-Hamiltonian reduction from the space of representations of the quiver. Three families of Poisson-commuting functions are constructed and written explicitly in suitable Darboux coordinates. The case m = 1 corresponds to the tadpole quiver and the Ruijsenaars-Schneider system and its variants, while for m > 1 we obtain new integrable systems that generalise the Ruijsenaars-Schneider system. These systems and their quantum versions also appeared recently in the context of supersymmetric gauge theory and cyclotomic DAHAs (Braverman et al. [32,34,35] and Kodera and Nakajima [36]), as well as in the context of the Macdonald theory (Chalykh and Etingof, 2013).

The State of Water in Proton Conducting Membranes

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Allcock, Harry R.; Benesi, Alan; Macdonald, Digby D.

2010-08-27

The research carried out under grant No. DE-FG02-07ER46371, "The State of Water in Proton Conducting Membranes", during the period June 1, 2008 - May 31, 2010 was comprised of three related parts. These are: 1. An examination of the state of water in classical proton conduction membranes with the use of deuterium T1 NMR spectroscopy (Allcock and Benesi groups). 2. A dielectric relaxation examination of the behavior of water in classical ionomer membranes (Macdonald program). 3. Attempts to synthesize new proton-conduction polymers and membranes derived from the polyphosphazene system. (Allcock program) All three are closely related, crucial aspects of the design and development of new and improved polymer electrolyte fuel cell membranes on which the future of fuel cell technology for portable applications depends.

Managing the Future Imaginary: Does ‘Post-Normal’ Science need Public Relations?

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James Michael MacFarlane

2018-03-01

Existing literature in this area has typically focused on perceived benefits of social-scientist driven AG as ‘Real Time Technology Assessment’ (RTTA, rather than address how such participation — in line with STS’s contemporary post-social, object-centred, anti-normative research character — relates to a lack of institutional protection for most STS practitioners today. I argue the activities of social science researchers enrolled in AG-styled programmes appears to closely resemble those of PR professionals, and as such, in today’s knowledge economy the field could have much to gain by turning to clarify and formalise the unique cognitive-base and normative horizons befitting of a closed occupational group. I suggest an occupational restructuring in line with the ‘professional project’ (Macdonald, 1995 could bring about increased autonomy for STS practitioners, as well as purposeful direction for future research.

Ontario energy market review and outlook

International Nuclear Information System (INIS)

Brett, J.T.

1997-01-01

The current status of the natural gas industry and the electric power industry in Ontario, in terms of deregulation, was described. Natural gas utilities will exit the regulated gas market over the next few years and transfer their existing residential and small commercial gas contracts to their unregulated affiliates. Nevertheless, a regulated gas supply option will remain until the regulator is assured that consumer protection issues have been properly addressed, and there is a truly competitive market. Ontario Hydro is a vertically integrated virtual monopoly. It lags behind B.C., Alberta, Quebec and Nova Scotia in terms of deregulation and restructuring, although the MacDonald Commission's recent report recommended sweeping changes to Ontario Hydro's monopoly over the electric power industry. A final response from the Ontario government is still pending. The convergence of the electric power and natural gas industries was also discussed

Reply to Macreadie et al Comment on ‘Geoengineering with seagrasses: is credit due where credit is given?’

Science.gov (United States)

Johannessen, Sophia C.; Macdonald, Robie W.

2018-02-01

Macreadie et al (this issue; M2017 Environ. Res. Lett.) challenged the conclusion presented by Johannessen and Macdonald (2016 Environ. Res. Lett.) that global estimates of carbon sequestration by seagrass meadows were too high. Here we clarify our global calculation, respond to M2017’s criticisms and explain how the persistent misunderstandings about sediment dynamics within the Blue Carbon community continue to lead to overestimates of carbon sequestration in seagrass meadows. We point out that, although seagrasses appear to have a local effect on carbon sequestration compared with nearby barren sediments, their preferred substrate (slowly-accumulating, coarse sediment) makes them among the least effective coastal environments for burying carbon. We conclude with a proposal for the development of robust international protocols to quantify carbon burial in seagrass meadows that account for sediment accumulation, sediment mixing and carbon remineralization.

Particle-hole symmetry and composite fermions in fractional quantum Hall states

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Nguyen, Dung Xuan; Golkar, Siavash; Roberts, Matthew M.; Son, Dam Thanh

2018-05-01

We study fractional quantum Hall states at filling fractions in the Jain sequences using the framework of composite Dirac fermions. Synthesizing previous work, we write an effective field theory consistent with all symmetry requirements, including Galilean invariance and particle-hole symmetry. Employing a Fermi-liquid description, we demonstrate the appearance of the Girvin-Macdonald-Platzman algebra and compute the dispersion relation of neutral excitations and various response functions. Our results satisfy requirements of particle-hole symmetry. We show that while the dispersion relation obtained from the modified random-phase approximation (MRPA) of the Halperin-Lee-Read (HLR) theory is particle-hole symmetric, correlation functions obtained from this scheme are not. The results of the Dirac theory are shown to be consistent with the Haldane bound on the projected structure factor, while those of the MPRA of the HLR theory violate it.

Generalized study of the return to equilibrium of a particle in a plasma (Fokker-Planck formalism) (1961); Etude generale du retour a l'equilibre d'une particule au sein d'un plasma (formalisme de Fokker-Planck) (1961)

Energy Technology Data Exchange (ETDEWEB)

Salmon, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Faculte des Sciences de Caen, 14 (France)

1961-07-01

The author examines the problem of the return to equilibrium of a particle in a plasma and completely explains Fokker-Planck equation. After that, he studies the possibility of interpreting the return of the test particle to Maxwellian distribution, using the development - which is obtained. He discusses the validity limits of the Rosenbluth, MacDonald and Judd approximation. (author) [French] Examinant le probleme du retour a l'equilibre d'une particule test au sein d'un plasma en equilibre, l'auteur cherche a expliciter completement l'expression de l'operateur de Fokker-Planck. Il etudie ensuite les conditions de coherence, c'est-a-dire la possibilite pour le developpement obtenu de traduire le retour de la particule test a l'etat maxwellien et discute des limites de validite de la formule de 'Rosenbluth, Mac Donald et Judd'. (auteur)

Theory in learning technology

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Laura Czerniewicz

2011-12-01

Full Text Available This special issue is being published at a significant point in time in relation tosimultaneous changes in higher education, in technology and in the field of learningtechnology itself. As the 2011 ALT C conference themes clearly state, learningtechnology needs to learn to thrive in a colder and more challenging climate. In thisdifficult political and economic environment technological trends continue todevelop in terms of mobility, cloud computing, ubiquity and the emergence of whathas been called big data. E-learning has become mainstream and the field of learningtechnology itself is beginning to stabilise as a profession. Profession here isunderstood as a knowledge-based occupation and a form of cultural work where thetasks addressed are human problems amenable to expert advice and distinguishablefrom other kinds of work by the fact that it is underpinned by abstract knowledge(Macdonald, 1995.

Featuring animacy

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Elizabeth Ritter

2015-01-01

Full Text Available Algonquian languages are famous for their animacy-based grammatical properties—an animacy based noun classification system and direct/inverse system which gives rise to animacy hierarchy effects in the determination of verb agreement. In this paper I provide new evidence for the proposal that the distinctive properties of these languages is due to the use of participant-based features, rather than spatio-temporal ones, for both nominal and verbal functional categories (Ritter & Wiltschko 2009, 2014. Building on Wiltschko (2012, I develop a formal treatment of the Blackfoot aspectual system that assumes a category Inner Aspect (cf. MacDonald 2008, Travis 1991, 2010. Focusing on lexical aspect in Blackfoot, I demonstrate that the classification of both nouns (Seinsarten and verbs (Aktionsarten is based on animacy, rather than boundedness, resulting in a strikingly different aspectual system for both categories. 

Acquired hypofibrinogenemia: current perspectives

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Besser MW

2016-09-01

Full Text Available Martin W Besser,1 Stephen G MacDonald2 1Department of Haematology, 2Department of Specialist Haemostasis, The Pathology Partnership, Addenbrooke’s Hospital, Cambridge, UK Abstract: Acquired hypofibrinogenemia is most frequently caused by hemodilution and consumption of clotting factors. The aggressive replacement of fibrinogen has become one of the core principles of modern management of massive hemorrhage. The best method for determining the patient’s fibrinogen level remains controversial, and particularly in acquired dysfibrinogenemia, could have major therapeutic implications depending on which quantification method is chosen. This review introduces the available laboratory and point-of-care methods and discusses the relative advantages and limitations. It also discusses current strategies for the correction of hypofibrinogenemia. Keywords: Clauss fibrinogen assay, fibrinogen antigen, viscoelastic testing, ­gravimetric fibrinogen assay, PT-derived fibrinogen, functional fibrinogen, direct oral anticoagulant, dysfibrinogenemia, afibrinogenemia

Some Connections between the Spherical and Parabolic Bases on the Cone Expressed in terms of the Macdonald Function

OpenAIRE

Shilin, I. A.; Choi, Junesang

2014-01-01

Computing the matrix elements of the linear operator, which transforms the spherical basis of $SO(3,1)$ -representation space into the hyperbolic basis, very recently, Shilin and Choi (2013) presented an integral formula involving the product of two Legendre functions of the first kind expressed in terms of ${ }_{4}{F}_{3}$ -hypergeometric function and, using the general Mehler-Fock transform, another integral formula for the Legendre function of the first kind. In the sequel, we investigate ...

Relation of tolerance of ambiguity to global and specific paranormal experience.

Science.gov (United States)

Houran, J; Williams, C

1998-12-01

We examined the relationship of tolerance of ambiguity to severe global factors and specific types of anomalous or paranormal experience. 107 undergraduate students completed MacDonald's 1970 AT-20 and the Anomalous Experiences Inventory of Kumar, Pekala, and Gallagher. Scores on the five subscales of the Anomalous Experiences Inventory correlated differently with tolerance of ambiguity. Global paranormal beliefs, abilities, experiences, and drug use were positively associated with tolerance of ambiguity, whereas a fear of paranormal experience showed a negative relation. The specific types of anomalous experiences that correlated with tolerance of ambiguity often involved internal or physiological experience, e.g., precognitive dreams, memories of reincarnation, visual apparitions, and vestibular alterations. We generally found no effects of age of sex. These results are consistent with the idea that some paranormal experiences are misattributions of internal experience to external ('paranormal') sources, a process analogous to mechanisms underpinning delusions and hallucinations.

Effect of truncated cone roughness element density on hydrodynamic drag

Science.gov (United States)

Womack, Kristofer; Schultz, Michael; Meneveau, Charles

2017-11-01

An experimental study was conducted on rough-wall, turbulent boundary layer flow with roughness elements whose idealized shape model barnacles that cause hydrodynamic drag in many applications. Varying planform densities of truncated cone roughness elements were investigated. Element densities studied ranged from 10% to 79%. Detailed turbulent boundary layer velocity statistics were recorded with a two-component LDV system on a three-axis traverse. Hydrodynamic roughness length (z0) and skin-friction coefficient (Cf) were determined and compared with the estimates from existing roughness element drag prediction models including Macdonald et al. (1998) and other recent models. The roughness elements used in this work model idealized barnacles, so implications of this data set for ship powering are considered. This research was supported by the Office of Naval Research and by the Department of Defense (DoD) through the National Defense Science & Engineering Graduate Fellowship (NDSEG) Program.

Relationship of Life Satisfaction and Job Satisfaction among Pakistani Army Soldiers

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Summaira Naz

2015-03-01

Full Text Available The present study had two main objectives; first, to discover the relationships between job satisfaction and life satisfaction in Pakistani army soldiers, second, to find out the age, salary, marital status, and education differences on job satisfaction and life satisfaction in Pakistani army soldiers. In the present study two questionnaires; Job Satisfaction Scale JSS (Macdonald & Maclntyre, 1997 and Satisfaction With Life Scale (Diener, et al., 1985; were administered to a sample (N=400 along with a demographic sheet. The results of the study revealed a significant positive correlation between job satisfaction and life satisfaction of Pakistani army soldiers. The findings of the study also showed a significant age, education, salary, and marital status differences in job satisfaction and life satisfaction. Age, marital status, and salary variables had positive correlation with job satisfaction and life satisfaction but education had a negative association with job satisfaction and life satisfaction

Maximizing your ability to compete as a municipal electrical utility

International Nuclear Information System (INIS)

MacOdrum, B.

1996-01-01

The implications of the MacDonald Committee's recommendations on introducing competition to Ontario's electricity industry were reviewed from the point of view of Toronto Hydro, the largest municipal utility and Ontario Hydro's largest customer. Issues examined included (1) the consequences of unbundling Ontario Hydro's generating, transmission and distribution functions, (2) the structural change option of phasing-in competition among Ontario Hydro and municipal and other private generators, (3) enhancing the efficiency of the distribution sector, and (4) the relative benefits and consequences of private equity as a means of enhancing competition through the sale of Ontario Hydro's generating assets, or the sale of non-essential business operations. Recommendations to the Committee included the need for the transmission grid to remain under public control, for electricity pricing to take into account the variable environmental impact of different generating types, and the need for transferring regulatory authority over municipal electric utilities from Ontario Hydro to the Ontario Energy Board

Nonlinear and Nonequilibrium Spin Injection in Magnetic Tunneling Junctions

Science.gov (United States)

Guo, Hong

2007-03-01

Quantitative analysis of charge and spin quantum transport in spintronic devices requires an atomistic first principles approach that can handle nonlinear and nonequilibrium transport conditions. We have developed an approach for this purpose based on real space density functional theory (DFT) carried out within the Keldysh nonequilibrium Green's function formalism (NEGF). We report theoretical analysis of nonlinear and nonequilibrium spin injection and quantum transport in Fe/MgO/Fe trilayer structures as a function of external bias voltage. Devices with well relaxed atomic structures and with FeO oxidization layers are investigated as a function of external bias voltage. We also report calculations of nonequilibrium spin injection into molecular layers and graphene. Comparisons to experimental data will be presented. Work in collaborations with: Derek Waldron, Vladimir Timochevski (McGill University); Ke Xia (Institute of Physics, Chinese Academy of Science, Beijing, China); Eric Zhu, Jian Wang (University of Hong Kong); Paul Haney, and Allan MacDonald (University of Texas at Austin).

Music, health, and well-being: a review.

Science.gov (United States)

MacDonald, Raymond A R

2013-08-07

The relationship between arts participation and health is currently very topical. Motivated by a desire to investigate innovative, non-invasive, and economically viable interventions that embrace contemporary definitions of health, practitioners and researchers across the world have been developing and researching arts inventions. One of the key drivers in this vigorous research milieu is the growth of qualitative research within health care contexts and researchers interested in exploring the potential benefits of musical participation have fully embraced the advances that have taken place in health-related qualitative research. The following article presents a number of different types of qualitative research projects focused on exploring the process and outcomes of music interventions. It also presents a new conceptual model for music, health and well-being. This new model develops on a previous version of MacDonald, Kreutz, and Mitchell (2012b) by incorporating new elements and contextualization and providing detailed experimental examples to support the various components.

Current options for the treatment of optic neuritis

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Pula JH

2012-07-01

Full Text Available John H Pula,1 Christopher J MacDonald21Division of Neuro-ophthalmology, University of Illinois College of Medicine at Peoria, Peoria; 2University of Illinois College of Medicine at Urbana-Champaign, Champaign, IL, USAAbstract: Optic neuritis can be defined as typical (associated with multiple sclerosis, improving independent of steroid treatment, or atypical (not associated with multiple sclerosis, steroid-dependent improvement. Causes of atypical optic neuritis include connective tissue diseases (eg, lupus, vasculitis, sarcoidosis, or neuromyelitis optica. In this manuscript, updated treatment options for both typical and atypical optic neuritis are reviewed. Conventional treatments, such as corticosteroids, therapeutic plasma exchange, and intravenous immunoglobulin therapy are all discussed with commentary regarding evidence-based outcomes. Less commonly used treatments and novel purported therapies for optic neuritis are also reviewed. Special scenarios in the treatment of optic neuritis – pediatric optic neuritis, acute demyelinating encephalomyelitis, and optic neuritis occurring during pregnancy – are specifically examined.Keywords: optic neuritis, optic neuropathy, treatment, neuroophthalmology

Walking Women: Embodied Perception in Romantic and Contemporary Radical Landscape Poetry

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Eleanore Widger

2017-01-01

Full Text Available Reading early Wordsworth through Adorno, this article suggests that Romantic walking entails the subjugation of external objects through the exercise of an imperial and elevated perception. It then considers Dorothy Wordsworth’s influence over her brother and the possibility that a Romantic ‘eco-poetic’ emerges from the ‘feminine’ perspective 'below' the mountain, and within the domestic landscape. I argue that this gesture away from walking and mountaineering as the demonstration of physical prowess, or as the pursuit of a real or ideal goal, is taken up by three contemporary women poets of landscape. Harriet Tarlo, Frances Presley and Helen Macdonald offer different ways of walking, which dispense with goal-orientation, explore the ethical choices available to perceptual beings, and attempt a more immersive, embodied engagement with the land. Their contribution to contemporary ‘radical landscape poetry’ combines the feminist discourse of ‘situated knowledge’ with an implicitly enactivist approach to human encounters with the environment.

Neutral excitations in the Gaffnian state

Science.gov (United States)

Kang, Byungmin; Moore, Joel E.

2017-06-01

We study a model fractional quantum Hall (FQH) wave function called the Gaffnian state, which is believed to represent a gapless, strongly correlated state that is very different from conventional metals. To understand this exotic gapless state better, we provide a representation based on work of Halperin in which the pairing structure of the Gaffnian state becomes more explicit. We employ the single-mode approximation introduced by Girvin, MacDonald, and Platzman, here extended to three-body interactions, in order to treat a neutral collective excitation mode in order to clarify the physical origin of the gaplessness of the Gaffnian state. We discuss approaches to extract systematically the relevant physics in the long-distance, large-electron-number limit of FQH states using numerical calculations with relatively few electrons. In Appendices, we provide second-quantized expressions for many-body Haldane pseudopotentials in various geometries including the plane, sphere, cylinder, and torus based on the proper definition of the relative angular momentum.

k-Schur functions and affine Schubert calculus

CERN Document Server

Lam, Thomas; Morse, Jennifer; Schilling, Anne; Shimozono, Mark; Zabrocki, Mike

2014-01-01

This book gives an introduction to the very active field of combinatorics of affine Schubert calculus, explains the current state of the art, and states the current open problems. Affine Schubert calculus lies at the crossroads of combinatorics, geometry, and representation theory. Its modern development is motivated by two seemingly unrelated directions. One is the introduction of k-Schur functions in the study of Macdonald polynomial positivity, a mostly combinatorial branch of symmetric function theory. The other direction is the study of the Schubert bases of the (co)homology of the affine Grassmannian, an algebro-topological formulation of a problem in enumerative geometry. This is the first introductory text on this subject. It contains many examples in Sage, a free open source general purpose mathematical software system, to entice the reader to investigate the open problems. This book is written for advanced undergraduate and graduate students, as well as researchers, who want to become familiar with ...

The dynamics of endemic malaria in populations of varying size

International Nuclear Information System (INIS)

Ngwa, G.A.

2001-10-01

A mathematical model for endemic malaria involving variable human and mosquito populations is analysed. A threshold parameter R 0 exists and the disease can persist if and only if R 0 exceeds 1. R 0 is seen to be a generalisation of the basic reproduction ratio associated with the Ross-Macdonald model for malaria transmission. The disease free equilibrium always exist and is globally stable when R 0 is below 1. A perturbation analysis is used to approximate the endemic equilibrium in the important case where the disease related death rate is nonzero. A diffusion approximation is used to approximate the quasi-stationary distribution of the associated stochastic model. Numerical simulations show that when R 0 is distinctly greater than 1, the endemic deterministic equilibrium is globally stable. Furthermore, in quasi-stationarity, the stochastic process undergoes oscillations about a mean population whose size can be approximated by the stable endemic deterministic equilibrium. (author)

Ontario electricity industry restructuring

International Nuclear Information System (INIS)

1999-01-01

The objective of Ontario's electricity industry restructuring was described as an effort to enhance Ontario's competitiveness. It is believed that restructuring can be accomplished without an increase in electricity rates. In a series of charts, the report provides the timeline of restructuring from the time of the Macdonald report in 1995 to the beginning of open competition in Ontario electricity markets. It oulines the principles underlying the financial restructuring and the financial results of restructuring, including the size of the stranded debt ($ 7.8 billion). It lists the changes that have occurred since October 1998, explains some key factors in valuing the successor companies and profiles the Ontario Electricity Financial Corporation. Restructuring of the industry is expected to have a neutral to positive impact on Ontario's fiscal position. The residual stranded debt of $7.8 billion will be retired through revenues generated by the electricity sector, without recourse to the Provincial Treasury. 9 figs

Music, health, and well-being: A review

Science.gov (United States)

2013-01-01

The relationship between arts participation and health is currently very topical. Motivated by a desire to investigate innovative, non-invasive, and economically viable interventions that embrace contemporary definitions of health, practitioners and researchers across the world have been developing and researching arts inventions. One of the key drivers in this vigorous research milieu is the growth of qualitative research within health care contexts and researchers interested in exploring the potential benefits of musical participation have fully embraced the advances that have taken place in health-related qualitative research. The following article presents a number of different types of qualitative research projects focused on exploring the process and outcomes of music interventions. It also presents a new conceptual model for music, health and well-being. This new model develops on a previous version of MacDonald, Kreutz, and Mitchell (2012b) by incorporating new elements and contextualization and providing detailed experimental examples to support the various components. PMID:23930991

Participatory evaluation in the New Public management La evaluación participativa en la Nueva Gestión Pública

Directory of Open Access Journals (Sweden)

Antonio Trinidad Requena

2011-05-01

Full Text Available Every evaluation process has some effects. The explicit ones will command the attention of the evaluators and those evaluated, while the implicit ones go unnoticed. However, the real power of evaluation lies in its implicit effects. Those being evaluated will adapt their personal and professional behavior to the parameters which the evaluation measures, which is one of the implicit effects of every evaluation. Thus, eventually, the model of intervention or management that underlies each evaluation is imposed, since it is the invisible force behind the review. On occasion, this is used to avoid conflict within public administration, since it permits the imposition of a model of management which otherwise would not be accepted by those involved. In response to such effects, evaluators may choose other perspectives, such as democratic evaluation which B. Macdonald (1991 proposes, since it is more a service to the community involved in the public policy or organization. In this case we will call it participatory evaluation.Todo proceso de evaluación tiene unos efectos, los explícitos son los que acaparan la atención de los evaluados y evaluadores, olvidándose de los efectos implícitos. Sin embargo, el autentico poder de la evaluación está en los efectos implícitos. Los implicado en la evaluación para evitar ser evaluado negativamente adaptaran su comportamiento personal y profesional a los parámetros que mide la evaluación, siendo uno de los efectos implícitos de toda evaluación; de esta manera al final se impondrá el modelo de intervención o gestión que subyace en toda evaluación, siendo la fuerza invisible de la evaluación, y en ocasiones utilizada para evitar conflictos dentro de la Administración pública, al permitir imponer un modelo de gestión que de otra manera no sería aceptado por los implicados. Atendiendo a tales efectos, la evaluación puede optar por otras perspectivas como la evaluación democrática que propone B

Effect of electron-electron interaction on cyclotron resonance in high-mobility InAs/AlSb quantum wells

Energy Technology Data Exchange (ETDEWEB)

Krishtopenko, S. S., E-mail: sergey.krishtopenko@mail.ru; Gavrilenko, V. I. [Institute for Physics of Microstructures, Russian Academy of Sciences, 603950 Nizhny Novgorod, GSP-105 (Russian Federation); Lobachevsky State University, 23 Prospekt Gagarina, 603950 Nizhny Novgorod (Russian Federation); Ikonnikov, A. V. [Institute for Physics of Microstructures, Russian Academy of Sciences, 603950 Nizhny Novgorod, GSP-105 (Russian Federation); Orlita, M. [Laboratoire National des Champs Magnétiques Intenses (LNCMI-G), CNRS, 25 rue des Martyrs, B.P. 166, 38042 Grenoble (France); Sadofyev, Yu. G. [P.N. Lebedev Physical Institute, Russian Academy of Sciences, Moscow 119991, GSP-1, 53 Leninskiy Prospect (Russian Federation); Goiran, M. [Laboratoire National des Champs Magnétiques Intenses (LNCMI-T), CNRS, 143 Avenue de Rangueil, 31400 Toulouse (France); Teppe, F.; Knap, W. [Laboratoire Charles Coulomb (L2C), UMR CNRS 5221, GIS-TERALAB, Universite Montpellier II, 34095 Montpellier (France)

2015-03-21

We report observation of electron-electron (e-e) interaction effect on cyclotron resonance (CR) in InAs/AlSb quantum well heterostructures. High mobility values allow us to observe strongly pronounced triple splitting of CR line at noninteger filling factors of Landau levels ν. At magnetic fields, corresponding to ν > 4, experimental values of CR energies are in good agreement with single-electron calculations on the basis of eight-band k ⋅ p Hamiltonian. In the range of filling factors 3 < ν < 4 pronounced, splitting of CR line, exceeding significantly the difference in single-electron CR energies, is discovered. The strength of the splitting increases when occupation of the partially filled Landau level tends to a half, being in qualitative agreement with previous prediction by MacDonald and Kallin [Phys. Rev. B 40, 5795 (1989)]. We demonstrate that such behaviour of CR modes can be quantitatively described if one takes into account both electron correlations and the mixing between conduction and valence bands in the calculations of matrix elements of e-e interaction.

Rectangular superpolynomials for the figure-eight knot 41

Science.gov (United States)

Kononov, Ya. A.; Morozov, A. Yu.

2017-11-01

We rewrite the recently proposed differential expansion formula for HOMFLY polynomials of the knot 41 in an arbitrary rectangular representation R = [rs] as a sum over all Young subdiagrams λ of R with surprisingly simple coefficients of the Z factors. Intriguingly, these coefficients are constructed from the quantum dimensions of symmetric representations of the groups SL(r) and SL(s) and restrict the summation to diagrams with no more than s rows and r columns. Moreover, the β-deformation to Macdonald dimensions yields polynomials with positive integer coefficients, which are plausible candidates for the role of superpolynomials for rectangular representations. Both the polynomiality and the positivity of the coefficients are nonobvious, nevertheless true. This generalizes the previously known formulas for symmetric representations to arbitrary rectangular representations. The differential expansion allows introducing additional gradings. For the trefoil knot 31, to which our results for the knot 41 are immediately extended, we obtain the so-called fourth grading of hyperpolynomials. The property of factorization in roots of unity is preserved even in the five-graded case.

Three New Records of Gastropoda (Mollusca) from the Nansha Islands, China

Science.gov (United States)

Chen, Zhiyun; Shi, Wei; Gong, Li

2018-04-01

The Nansha Islands, China, have extremely high marine biodiversity and hundreds of mollusks have been reported there. Benthos resources investigations of the intertidal and subtidal zone around the Nansha Islands have been continuously performed for decades, and recently, dozens of new species and new records of mollusks have been reported from this area. This paper dealt with three new record species of the Gastropoda from Chinese waters: Cerithium salebrosum Sowerby II, 1855, Vexillum militare (Reeve, 1845) and Vexillum bizonale (Dautzenberg et Bouge, 1923), respectively belonging to three families: Cerithiidae Fleming, 1822, and Costellariidae MacDonald, 1860. All specimens were collected from the Nansha Islands during the benthos resources investigations on the intertidal zone of islands and reefs in the South China Sea in recent years. Diagnosis and geographic descriptions of both genus and species, illustrations of each species were given in this contribution, and discussion of taxonomy, identification features and faunal characteristics were presented. All examined specimens were deposited in the Marine Biodiversity Collections of South China Sea, Chinese Academy of Sciences.

PRAGMATIC DEFICITS OF ASPERGER SYNDROME

Directory of Open Access Journals (Sweden)

Silmy Arizatul Humaira’

2015-08-01

Full Text Available Human being is social creature who needs other people to interact with. One of the ways to interact with others is communication with language. However, communication could be a complicated problem for those who were born with developmental disorder called Asperger Syndrome (AS. The communication challenge of Asperger’s is the difficulty using language appropriately for social purposes or known as pragmatic deficits. Many excellent books about autism are published whereas knowledge on pragmatic deficits are still very limited. Thus, it is expected to be a beneficial reference to understand the pragmatic deficits and to create strategies for them to communicate effectively. Therefore, this study aimed at exploring the kinds of pragmatic deficits of an individual with AS. The verbal language profiles of autism purposed by MacDonald (2004 is used to analyzed the data in depth. The descriptive qualitative method is applied to develop a comprehensive understanding about the AS case in Temple Grandin movie.The finding shows that all of the five types of communication deficits are appearing and the dominant of which is unresponsive.

Atomic physics with highly charged ions. Progress report

Energy Technology Data Exchange (ETDEWEB)

Richard, P.

1994-08-01

The study of inelastic collision phenomena with highly charged projectile ions and the interpretation of spectral features resulting from these collisions remain as the major focal points in the atomic physics research at the J.R. Macdonald Laboratory, Kansas State University, Manhattan, Kansas. The title of the research project, ``Atomic Physics with Highly Charged Ions,`` speaks to these points. The experimental work in the past few years has divided into collisions at high velocity using the primary beams from the tandem and LINAC accelerators and collisions at low velocity using the CRYEBIS facility. Theoretical calculations have been performed to accurately describe inelastic scattering processes of the one-electron and many-electron type, and to accurately predict atomic transition energies and intensities for x rays and Auger electrons. Brief research summaries are given for the following: (1) electron production in ion-atom collisions; (2) role of electron-electron interactions in two-electron processes; (3) multi-electron processes; (4) collisions with excited, aligned, Rydberg targets; (5) ion-ion collisions; (6) ion-molecule collisions; (7) ion-atom collision theory; and (8) ion-surface interactions.

Electronic properties of moire superlattice bands in layered two dimensional materials

Science.gov (United States)

Jung, Jeil

2014-03-01

When atomically thin two-dimensional materials are layered they often form incommensurate non-crystalline structures that exhibit long period moiré patterns when examined by scanning probes. In this talk, I will present a theoretical method which can be used to derive an effective Hamiltonian for these twisted van der Waals heterostructures using input from ab initio calculations performed on short-period crystalline structures. I will argue that the effective Hamiltonian can quantitatively describe the electronic properties of these layered systems for arbitrary twist angle and lattice constants. Applying this method to the important cases of graphene on graphene and graphene on hexagonal-boron nitride, I will present a series of experimentally observable quantities that can be extracted from their electronic structure, including their density of states and local density of states as a function of twist angle, and compare with available experiments. Work done in collaboration with Allan MacDonald, Shaffique Adam, Arnaud Raoux, Zhenhua Qiao, and Ashley DaSilva; and supported by the Singapore National Research Foundation Fellowship NRF-NRFF2012-01.

Derivation of Green's function of a spin Calogero-Sutherland model by Uglov's method

International Nuclear Information System (INIS)

Nakai, Ryota; Kato, Yusuke

2009-01-01

The hole propagator of a spin 1/2 Calogero-Sutherland model is derived using Uglov's method, which maps the exact eigenfunctions of the model, called the Yangian Gelfand-Zetlin basis, to a limit of Macdonald polynomials (gl 2 -Jack polynomials). To apply this mapping method to the calculation of 1-particle Green's function, we confirm that the sum of the field annihilation operator ψ u + ψ ↓ on a Yangian Gelfand-Zetlin basis is transformed to the field annihilation operator ψ on gl 2 -Jack polynomials by the mapping. The resultant expression for the hole propagator for a finite-size system is written in terms of renormalized momenta and spin of quasi-holes, and the expression in the thermodynamic limit coincides with the earlier result derived by another method. We also discuss the singularity of the spectral function for a specific coupling parameter where the hole propagator of the spin Calogero-Sutherland model becomes equivalent to the dynamical colour correlation function of an SU(3) Haldane-Shastry model

Limits to the availability of groundwater in Africa

Science.gov (United States)

Edmunds, W. Mike

2012-06-01

The recent paper on Africa's groundwater by MacDonald et al (2012) has attracted much attention. This is good news, especially since groundwater has been widely ignored, misunderstood or abused, as a fundamental global resource. This important paper goes a long way to raising the profile of groundwater in Africa by providing first-order estimates of the available storage (taking account of saturated aquifer thickness and porosity) as well as mapping expected water yields (aquifer productivity) in that continent. Reliable estimates of groundwater resources can now be set against the far more widely reported surface water availability. The constraints of the methodology used to compile these maps are duly acknowledged, and are well within the hydrogeological state-of-the-art. The paper is backed by carefully reviewed sources of data and a considerable effort has been made to incorporate the extensive grey literature. It is important that this benchmark study is received with the acclaim it deserves. However, the headline—that groundwater storage is some 100 times the annual renewable surface waters—could be misconstrued as implying that groundwater is an abundant new resource, which it is not. Whilst groundwater is key to sustainable development, renewability and accessibility issues need to be addressed. The paper may therefore be seized upon to justify unsustainable groundwater exploitation, or to provide an argument against funding to NGOs and others, for water provision for needy communities. Some constraints that must be taken into account are elaborated here. The conclusions of the paper (MacDonald et al 2012) demonstrate that modest yields of groundwater are quite widely available at accessible depths and sufficient to sustain small communities and their development, but larger yields (>5 l s-1) suitable for urban development or major agricultural schemes are unlikely outside of the sedimentary terrain. The availability and accessibility of groundwater

Characterization of the terrigenous organic matter distribution in the bottom sediments of the East Siberian Arctic Shelf

Science.gov (United States)

Dudarev, Oleg; Charkin, Alexander; Semiletov, Igor; Gustafsson, Örjan; Vonk, Jorien; Sánchez-García, Laura

2010-05-01

The Arctic Ocean is a Mediterranean sea with exceptionally large shelves that account for approximately 50% of the total area of the enclosed ocean. Accordingly, the inorganic and organic character of the sediments both on the shelves and in the basins of the Arctic Ocean strongly reflect a pervasive influence from the surrounding land/thawing permafrost (Macdonald et al., 2008). The East Siberian Arctic Shelf (ESAS) is an enormous, shallow shelf that receives most of its particulate supply from coastal erosion A notable characteristic of the ESAS is an extremely large gradient of hydrological and biogeochemical parameters from Long Strait/Wrangell Island to the Lena River Delta that corresponds to geographically critical contrasts in the Arctic system where the Pacific and local shelf waters interact over the shelf (Semiletov et al., 2005). ESAS is clearly important region for storing and processing material that derives from the land and the sea. Here we synthesize the lithological and biogochemical data obtained in the ESAS by Laboratory of Arctic studies POI in cooperation with the IARC and SU during the last 10 years (1999-2009). Highest organic carbon (OC) concentrations in the surface sediment (up to 4w/w%) was found near mouths of major rivers (Lena, Yana, Indigirka, Alaseya, Kolyma), and near highly eroded coast (1-2 w/w %). .However, sedimentation over the major portion of shallow ESAS is dominated by coastal erosion not riverine runoff. It has been shown that contribution of terrestrial organic carbon (CTOM) is up to 100% in areas strongly impacted by coastal erosion. Lowest OC values (~0.1-0.5 w/w %) were found in the relic sediments of shoals (e.g. Semenovskaya, Vasilevskaya, and Diomid). New detail maps of distribution of sediment OC, CTOM, and C/N are considered along with the sediment sizing and mineralogical data. This multi-year study was supported by the Russian Foundation for Basic Research (Russian NSF), FEBRAS, NOAA, NSF, Wallenberg Foundation

Is Elevating Sir John A. Macdonald Really Worth It? Hitting the Reset Button on Canada's Founding Narrative in the Classroom

Science.gov (United States)

Gaudry, Adam

2017-01-01

This special issue of "Canadian Social Studies," entitled "Monumental Mistakes? Confronting Difficult Pasts," has brought together a diverse range of scholars offering insights into discussions regarding removing or altering monuments, buildings, and other reminders of difficult histories. The editors have requested that…

On equilibrium real exchange rates in euro area: Special focus on behavioral equilibrium exchange rates in Ireland and Greece

Directory of Open Access Journals (Sweden)

Klára Plecitá

2012-01-01

Full Text Available This paper focuses on the intra-euro-area imbalances. Therefore the first aim of this paper is to identify euro-area countries exhibiting macroeconomic imbalances. The subsequent aim is to estimate equilibrium real exchange rates for these countries and to compute their degrees of real exchange rate misalignment. The intra-area balance is assessed using the Cluster Analysis and the Principle Component Analysis; on this basis Greece and Ireland are selected as the two euro-area countries with largest imbalances in 2010. Further the medium-run equilibrium exchange rates for Greece and Ireland are estimated applying the Behavioral Equilibrium Exchange Rate (BEER approach popularised by Clark and MacDonald (1998. In addition, the long-run equilibrium exchange rates are estimated using the Permanent Equilibrium Exchange Rate (PEER model. Employing the BEER and PEER approaches on quarterly time series of real effective exchange rates (REER from 1997: Q1 to 2010: Q4 we identify an undervaluation of the Greek and Irish REER around their entrance to the euro area. For the rest of the period analysed their REER is broadly in line with estimated BEER and PEER levels.

Partially filled Landau level at even denominators: A vortex metal with a Berry phase

Science.gov (United States)

You, Yizhi

2018-04-01

We develop a vortex metal theory for a partially filled Landau level at ν =1/2 n whose ground state contains a composite Fermi surface formed by the vortex of electrons. In the projected Landau-level limit, the composite Fermi surface contains a -π/n Berry phase. Such a fractional Berry phase is a consequence of Landau-level projection which produces the Girvin-MacDonald-Platzman [S. M. Girvin, A. H. MacDonald, and P. M. Platzman, Phys. Rev. B 33, 2481 (1986), 10.1103/PhysRevB.33.2481] guiding center algebra and embellishes an anomalous velocity to the equation of motion for the vortex metal. Further, we investigate a particle-hole symmetric bilayer system with ν1=1/2 n and ν2=1 -1/2 n at each layer, and demonstrate that the -π/n Berry phase on the composite Fermi surface leads to the suppression of 2 kf backscattering between the particle-hole partner bilayer, which could be a smoking gun to detect the fractional Berry phase. We also mention various instabilities and competing orders in such bilayer systems, including a Z4 n topological order phase driven by quantum criticality.

Effects of Iodide and Hydrogen Peroxide on Measuring High Temperature pH in Various Lithium Borate Buffer Solutions

Energy Technology Data Exchange (ETDEWEB)

Hwang, Jae Sik; Yun, Myung Hee; Yeon, Jei Won; Song, Kyu Seok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2008-10-15

In a reactor coolant system of nuclear power plants, the need for reliable high temperature pH electrodes has resulted from interests in the corrosion and corrosion product behaviors of the structural materials in a high temperature coolant system. In developing the electrodes for measuring the high temperature pH of aqueous solutions, it is necessary to note two major problems: the chemical stability of an electrode against other chemical impurities, and an electrode's integrity as the temperature and pressure are varied between operational extremes. Over the past decade Macdonald et al. and Danielson et al. have developed many ceramic membrane pH electrodes based on a yttrium stabilized zirconium oxide. However, there are still many experimental difficulties associated with the problems in obtaining electrochemical information across different pressure boundaries and against many kinds of chemical impurities caused by the radiolysis of water and the leakage of a fuel clad. In the present work, we investigated the effects of the environmental factors on a high temperature pH. The selected environmental factors are as follows: system pressure, and chemical species such as iodide and hydrogen peroxide ions.

Book reviews

Directory of Open Access Journals (Sweden)

Redactie KITLV

2012-05-01

Full Text Available Chie Ikeya, Refiguring women, colonialism, and modernity in Burma (Henk Schulte Nordholt Thomas J. Conners, Mason C. Hoadley, Frank Dhont, Kevin Ko (eds, Pancasila’s contemporary appeal: Relegitimizing Indonesia’s founding ethos (R.E. Elson I Nyoman Darma Putra, A literary mirror: Balinese reflections on modernity and identity in the twentieth century (Dick van der Meij Margaret Jolly. Serge Tcherkézoff and Darrell Tryon (eds, Oceanic encounters: Exchange, desire, violence (H.J.M. Claessen Rudolf Mrázek, A certain age: Colonial Jakarta through the memories of its intellectuals (Lutgard Mutsaers Jan Ovesen and Ing-Britt Trankell, Cambodians and their doctors: A medical anthropology of colonial and post-colonial Cambodia (Vivek Neelakantan Daromir Rudnyckyj, Spiritual economies: Islam, globalization and the afterlife of development (Gabrial Facal Claudine Salmon, Sastra Indonesia awal: Kontribusi orang Tionghoa (Melani Budianta Renate Sternagel, Der Humboldt von Java: Leben und Werk des Naturforschers Franz Wilhelm Junghuhn 1809-1864 (Andreas Weber Wynn Wilcox (ed., Vietnam and the West: New approaches (Hans Hägerdal Zheng Yangwen and Charles J.H Macdonald (eds, Personal names in Asia: History, culture and identity (Rosemary Gianno

Picosecond ion pulses from an EN tandem created by a femtosecond Ti:sapphire laser

International Nuclear Information System (INIS)

Carnes, K.D.; Cocke, C.L.; Chang, Z.; Ben-Itzhak, I.; Needham, H.V.; Rankin, A.

2007-01-01

As the James R. Macdonald Laboratory at Kansas State University continues its transformation from an ion collisions facility to an ultrafast laser/ion collisions facility, we are looking for novel ways to combine our traditional accelerator expertise with our new laser capabilities. One such combination is to produce picosecond pulses of stripping gas ions in the high energy accelerating tube of our EN tandem by directing ∼100 fs, sub-milliJoule laser pulses up the high energy end of the tandem toward a focusing mirror at the terminal. Ion pulses from both stripping and residual gas have been produced and identified, with pulse widths thus far on the order of a nanosecond. This width represents an upper limit, as it is dominated by pulse-to-pulse jitter in the ion time-of-flight (TOF) and is therefore not a true representation of the actual pulse width. In this paper, we describe the development process and report on the results to date. Conditions limiting the minimum temporal pulse width, such as tandem terminal ripple, thermal motion of the gas and space charge effects, are also outlined

The impact of radiolytic yield on the calculated ECP in PWR primary coolant circuits

International Nuclear Information System (INIS)

Urquidi-Macdonald, Mirna; Pitt, Jonathan; Macdonald, Digby D.

2007-01-01

A code, PWR-ECP, comprising chemistry, radiolysis, and mixed potential models has been developed to calculate radiolytic species concentrations and the corrosion potential of structural components at closely spaced points around the primary coolant circuits of pressurized water reactors (PWRs). The pH(T) of the coolant is calculated at each point of the primary-loop using a chemistry model for the B(OH) 3 + LiOH system. Although the chemistry/radiolysis/mixed potential code has the ability to calculate the transient reactor response, only the reactor steady state condition (normal operation) is discussed in this paper. The radiolysis model is a modified version of the code previously developed by Macdonald and coworkers to model the radiochemistry and corrosion properties of boiling water reactor primary coolant circuits. In the present work, the PWR-ECP code is used to explore the sensitivity of the calculated electrochemical corrosion potential (ECP) to the set of radiolytic yield data adopted; in this case, one set had been developed from ambient temperature experiments and another set reported elevated temperatures data. The calculations show that the calculated ECP is sensitive to the adopted values for the radiolytic yields

Calculations of thermophysical properties of cubic carbides and nitrides using the Debye-Grueneisen model

International Nuclear Information System (INIS)

Lu Xiaogang; Selleby, Malin; Sundman, Bo

2007-01-01

The thermal expansivities and heat capacities of MX (M = Ti, Zr, Hf, V, Nb, Ta; X = C, N) carbides and nitrides with NaCl structure were calculated using the Debye-Grueneisen model combined with ab initio calculations. Two different approximations for the Grueneisen parameter γ were used in the Debye-Grueneisen model, i.e. the expressions proposed by Slater and by Dugdale and MacDonald. The thermal electronic contribution was evaluated from ab initio calculations of the electronic density of states. The calculated results were compared with CALPHAD assessments and experimental data. It was found that the calculations using the Dugdale-MacDonald γ can account for most of the experimental data. By fitting experimental heat capacity and thermal expansivity data below the Debye temperatures, an estimation of Poisson's ratio was obtained and Young's and shear moduli were evaluated. In order to reach a reasonable agreement with experimental data, it was necessary to use the logarithmic averaged mass of the constituent atoms. The agreements between the calculated and the experimental values for the bulk and Young's moduli are generally better than the agreement for shear modulus

Use of stochastic methods for robust parameter extraction from impedance spectra

International Nuclear Information System (INIS)

Bueschel, Paul; Troeltzsch, Uwe; Kanoun, Olfa

2011-01-01

The fitting of impedance models to measured data is an essential step in impedance spectroscopy (IS). Due to often complicated, nonlinear models, big number of parameters, large search spaces and presence of noise, an automated determination of the unknown parameters is a challenging task. The stronger the nonlinear behavior of a model, the weaker is the convergence of the corresponding regression and the probability to trap into local minima increases during parameter extraction. For fast measurements or automatic measurement systems these problems became the limiting factors of use. We compared the usability of stochastic algorithms, evolution, simulated annealing and particle filter with the widely used tool LEVM for parameter extraction for IS. The comparison is based on one reference model by J.R. Macdonald and a battery model used with noisy measurement data. The results show different performances of the algorithms for these two problems depending on the search space and the model used for optimization. The obtained results by particle filter were the best for both models. This method delivers the most reliable result for both cases even for the ill posed battery model.

Religiosity and Spirituality as Predictors of Subjectively Perceived Happiness in University Students in Slovakia

Directory of Open Access Journals (Sweden)

Peter Babinčák

2016-03-01

Full Text Available Several research projects discuss the existence of weak to moderately strong positive relation between religiosity/spirituality on the one hand and subjective well-being, life satisfaction or quality of life on the other hand (see Kelley & Miller, 2007. Variables related to religiosity and spirituality of a person may be perceived in two ways: as protective factors of attaining subjective well-being or as barriers limiting its attainment. The objective of this study is verification of mutual relationship between the indicators of religiosity and spirituality with regard to subjectively perceived happiness and verification of predictive strength of these indicators with regard to subjective happiness. The sample of research participants consisted of 194 university students aged 18 to 26. The research used 4 tools: The Expressions of Spirituality Inventory-Revised (MacDonald, 2000, The Salience in Religious Commitment Scale (Roof & Perkins, 1975, Subjective Happiness Scale (Lyubomirsky & Lepper, 1999 and The Oxford Happiness Questionnaire (Hills & Argyle, 2002. Using multiple hierarchical linear regression (stepwise, we obtained 2 dimensions of spirituality as significant predictors of subjective happiness – Existential Well-Being and Experiential/Phenomenological Dimension. Demographic data and confession types were not proved as predictors of happiness.

Experimental Assessment of the Hydraulics of a Miniature Axial-Flow Left Ventricular Assist Device

Science.gov (United States)

Smith, P. Alex; Cohn, William; Metcalfe, Ralph

2017-11-01

A minimally invasive partial-support left ventricular assist device (LVAD) has been proposed with a flow path from the left atrium to the arterial system to reduce left ventricular stroke work. In LVAD design, peak and average efficiency must be balanced over the operating range to reduce blood trauma. Axial flow pumps have many geometric parameters. Until recently, testing all these parameters was impractical, but modern 3D printing technology enables multi-parameter studies. Following theoretical design, experimental hydraulic evaluation in steady state conditions examines pressure, flow, pressure-flow gradient, efficiency, torque, and axial force as output parameters. Preliminary results suggest that impeller blades and stator vanes with higher inlet angles than recommended by mean line theory (MLT) produce flatter gradients and broader efficiency curves, increasing compatibility with heart physiology. These blades also produce less axial force, which reduces bearing load. However, they require slightly higher torque, which is more demanding of the motor. MLT is a low order, empirical model developed on large pumps. It does not account for the significant viscous losses in small pumps like LVADs. This emphasizes the importance of experimental testing for hydraulic design. Roderick D MacDonald Research Fund.

Watery Existence: immaginari dell’acqua tra arte e letteratura nella poetica modernista

Directory of Open Access Journals (Sweden)

Giulia Gorgoglione

2011-11-01

Full Text Available Water has always been an element of border and threshold, both as a political frontier between nations, and in the symbolic value of transition between life and death, between the real world and beyond, between silence and narration. Modernist poetry is characterized by the presence of this element (Woolf, Eliot both as a term of reflection on the human existence and as a symbol of human life in its flexibility, inconsistency, strength and dissolution. This article looks at the different implications of visual and literary works that are substantiated in the imagination of the water. Water represents the creative desire of the narration (Virginia Woolf, The Waves that runs smoothly in the recesses of the human psyche, and contrasts with the aridity of silence that corresponds to a lack of logos. Water represents a desire for origins (To The Lighthouse, but also for maternal death (death by water and total dissolution. Visual arts mirror this awareness, especially in the extensive series of depictions of the character of Ophelia (Margaret MacDonald, WGSimmonds, Steck. Water is here the dominant pictorial element, symbol of the innate human tendency to cross the boundary between the human and divine.

High-repetition-rate setup for pump-probe time-resolved XUV-IR experiments employing ion and electron momentum imaging

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Pathak, Shashank; Robatjazi, Seyyed Javad; Wright Lee, Pearson; Raju Pandiri, Kanaka; Rolles, Daniel; Rudenko, Artem

2017-04-01

J.R. Macdonald Laboratory, Department of Physics, Kansas State University, Manhattan KS, USA We report on the development of a versatile experimental setup for XUV-IR pump-probe experiments using a 10 kHz high-harmonic generation (HHG) source and two different charged-particle momentum imaging spectrometers. The HHG source, based on a commercial KM Labs eXtreme Ultraviolet Ultrafast Source, is capable of delivering XUV radiation of less than 30 fs pulse duration in the photon energy range of 17 eV to 100 eV. It can be coupled either to a conventional velocity map imaging (VMI) setup with an atomic, molecular, or nanoparticle target; or to a novel double-sided VMI spectrometer equipped with two delay-line detectors for coincidence studies. An overview of the setup and results of first pump-probe experiments including studies of two-color double ionization of Xe and time-resolved dynamics of photoionized CO2 molecule will be presented. This project is supported in part by National Science Foundation (NSF-EPSCOR) Award No. IIA-1430493 and in part by the Chemical science, Geosciences, and Bio-Science division, Office of Basic Energy Science, Office of science, U.S. Department of Energy. K.

The transition probability and the probability for the left-most particle's position of the q-totally asymmetric zero range process

Energy Technology Data Exchange (ETDEWEB)

Korhonen, Marko [Department of Mathematics and Statistics, University of Helsinki, FIN-00014 (Finland); Lee, Eunghyun [Centre de Recherches Mathématiques (CRM), Université de Montréal, Quebec H3C 3J7 (Canada)

2014-01-15

We treat the N-particle zero range process whose jumping rates satisfy a certain condition. This condition is required to use the Bethe ansatz and the resulting model is the q-boson model by Sasamoto and Wadati [“Exact results for one-dimensional totally asymmetric diffusion models,” J. Phys. A 31, 6057–6071 (1998)] or the q-totally asymmetric zero range process (TAZRP) by Borodin and Corwin [“Macdonald processes,” Probab. Theory Relat. Fields (to be published)]. We find the explicit formula of the transition probability of the q-TAZRP via the Bethe ansatz. By using the transition probability we find the probability distribution of the left-most particle's position at time t. To find the probability for the left-most particle's position we find a new identity corresponding to identity for the asymmetric simple exclusion process by Tracy and Widom [“Integral formulas for the asymmetric simple exclusion process,” Commun. Math. Phys. 279, 815–844 (2008)]. For the initial state that all particles occupy a single site, the probability distribution of the left-most particle's position at time t is represented by the contour integral of a determinant.

Mathematical modeling of malaria infection with innate and adaptive immunity in individuals and agent-based communities.

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Gurarie, David; Karl, Stephan; Zimmerman, Peter A; King, Charles H; St Pierre, Timothy G; Davis, Timothy M E

2012-01-01

Agent-based modeling of Plasmodium falciparum infection offers an attractive alternative to the conventional Ross-Macdonald methodology, as it allows simulation of heterogeneous communities subjected to realistic transmission (inoculation patterns). We developed a new, agent based model that accounts for the essential in-host processes: parasite replication and its regulation by innate and adaptive immunity. The model also incorporates a simplified version of antigenic variation by Plasmodium falciparum. We calibrated the model using data from malaria-therapy (MT) studies, and developed a novel calibration procedure that accounts for a deterministic and a pseudo-random component in the observed parasite density patterns. Using the parasite density patterns of 122 MT patients, we generated a large number of calibrated parameters. The resulting data set served as a basis for constructing and simulating heterogeneous agent-based (AB) communities of MT-like hosts. We conducted several numerical experiments subjecting AB communities to realistic inoculation patterns reported from previous field studies, and compared the model output to the observed malaria prevalence in the field. There was overall consistency, supporting the potential of this agent-based methodology to represent transmission in realistic communities. Our approach represents a novel, convenient and versatile method to model Plasmodium falciparum infection.

Mathematical modeling of malaria infection with innate and adaptive immunity in individuals and agent-based communities.

Directory of Open Access Journals (Sweden)

David Gurarie

Full Text Available BACKGROUND: Agent-based modeling of Plasmodium falciparum infection offers an attractive alternative to the conventional Ross-Macdonald methodology, as it allows simulation of heterogeneous communities subjected to realistic transmission (inoculation patterns. METHODOLOGY/PRINCIPAL FINDINGS: We developed a new, agent based model that accounts for the essential in-host processes: parasite replication and its regulation by innate and adaptive immunity. The model also incorporates a simplified version of antigenic variation by Plasmodium falciparum. We calibrated the model using data from malaria-therapy (MT studies, and developed a novel calibration procedure that accounts for a deterministic and a pseudo-random component in the observed parasite density patterns. Using the parasite density patterns of 122 MT patients, we generated a large number of calibrated parameters. The resulting data set served as a basis for constructing and simulating heterogeneous agent-based (AB communities of MT-like hosts. We conducted several numerical experiments subjecting AB communities to realistic inoculation patterns reported from previous field studies, and compared the model output to the observed malaria prevalence in the field. There was overall consistency, supporting the potential of this agent-based methodology to represent transmission in realistic communities. CONCLUSIONS/SIGNIFICANCE: Our approach represents a novel, convenient and versatile method to model Plasmodium falciparum infection.

Targeting youth and concerned smokers: evidence from Canadian tobacco industry documents.

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Pollay, R W

2000-06-01

To provide an understanding of the targeting strategies of cigarette marketing, and the functions and importance of the advertising images chosen. Analysis of historical corporate documents produced by affiliates of British American Tobacco (BAT) and RJ Reynolds (RJR) in Canadian litigation challenging tobacco advertising regulation, the Tobacco Products Control Act (1987): Imperial Tobacco Limitee & RJR-Macdonald Inc c. Le Procurer General du Canada. Careful and extensive research has been employed in all stages of the process of conceiving, developing, refining, and deploying cigarette advertising. Two segments commanding much management attention are "starters" and "concerned smokers". To recruit starters, brand images communicate independence, freedom and (sometimes) peer acceptance. These advertising images portray smokers as attractive and autonomous, accepted and admired, athletic and at home in nature. For "lighter" brands reassuring health concerned smokers, lest they quit, advertisements provide imagery conveying a sense of well being, harmony with nature, and a consumer's self image as intelligent. The industry's steadfast assertions that its advertising influences only brand loyalty and switching in both its intent and effect is directly contradicted by their internal documents and proven false. So too is the justification of cigarette advertising as a medium creating better informed consumers, since visual imagery, not information, is the means of advertising influence.

eAMI: A Qualitative Quantification of Periodic Breathing Based on Amplitude of Oscillations

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Fernandez Tellez, Helio; Pattyn, Nathalie; Mairesse, Olivier; Dolenc-Groselj, Leja; Eiken, Ola; Mekjavic, Igor B.; Migeotte, P. F.; Macdonald-Nethercott, Eoin; Meeusen, Romain; Neyt, Xavier

2015-01-01

Study Objectives: Periodic breathing is sleep disordered breathing characterized by instability in the respiratory pattern that exhibits an oscillatory behavior. Periodic breathing is associated with increased mortality, and it is observed in a variety of situations, such as acute hypoxia, chronic heart failure, and damage to respiratory centers. The standard quantification for the diagnosis of sleep related breathing disorders is the apnea-hypopnea index (AHI), which measures the proportion of apneic/hypopneic events during polysomnography. Determining the AHI is labor-intensive and requires the simultaneous recording of airflow and oxygen saturation. In this paper, we propose an automated, simple, and novel methodology for the detection and qualification of periodic breathing: the estimated amplitude modulation index (eAMI). Patients or Participants: Antarctic cohort (3,800 meters): 13 normal individuals. Clinical cohort: 39 different patients suffering from diverse sleep-related pathologies. Measurements and Results: When tested in a population with high levels of periodic breathing (Antarctic cohort), eAMI was closely correlated with AHI (r = 0.95, P Dolenc-Groselj L, Eiken O, Mekjavic IB, Migeotte PF, Macdonald-Nethercott E, Meeusen R, Neyt X. eAMI: a qualitative quantification of periodic breathing based on amplitude of oscillations. SLEEP 2015;38(3):381–389. PMID:25581914

South African CSP projects under the REIPPP programme - Requirements, challenges and opportunities

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Relancio, Javier; Cuellar, Alberto; Walker, Gregg; Ettmayr, Chris

2016-05-01

Thus far seven Concentrated Solar Power (CSP) projects have been awarded under the Renewable Energy Independent Power Producer Procurement Programme (REIPPPP), totalling 600MW: one project is in operation, four under construction and two on their way to financial close. This provides an excellent opportunity for analysis of key features of the projects that have contributed to or detracted from the programme's success. The paper draws from Mott MacDonald's involvement as Technical Advisor on the seven CSP projects that have been successful under the REIPPPP to date as well as other global CSP developments. It presents how various programme requirements have affected the implementation of projects, such as the technical requirements, time of day tariff structure, economic development requirements and the renewable energy grid code. The increasingly competitive tariffs offered have encouraged developers to investigate efficiency maximising project configurations and cost saving mechanisms, as well as featuring state of the art technology in their proposals. The paper assesses the role of the project participants (developers, lenders and government) with regards to these innovative technologies and solutions. In our paper we discuss the status of projects and the SA market, analysing the main challenges and opportunities that in turn have influenced various aspects such as technology choice, operational regimes and supply chain arrangements.

Order recall in verbal short-term memory: The role of semantic networks.

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Poirier, Marie; Saint-Aubin, Jean; Mair, Ali; Tehan, Gerry; Tolan, Anne

2015-04-01

In their recent article, Acheson, MacDonald, and Postle (Journal of Experimental Psychology: Learning, Memory, and Cognition 37:44-59, 2011) made an important but controversial suggestion: They hypothesized that (a) semantic information has an effect on order information in short-term memory (STM) and (b) order recall in STM is based on the level of activation of items within the relevant lexico-semantic long-term memory (LTM) network. However, verbal STM research has typically led to the conclusion that factors such as semantic category have a large effect on the number of correctly recalled items, but little or no impact on order recall (Poirier & Saint-Aubin, Quarterly Journal of Experimental Psychology 48A:384-404, 1995; Saint-Aubin, Ouellette, & Poirier, Psychonomic Bulletin & Review 12:171-177, 2005; Tse, Memory 17:874-891, 2009). Moreover, most formal models of short-term order memory currently suggest a separate mechanism for order coding-that is, one that is separate from item representation and not associated with LTM lexico-semantic networks. Both of the experiments reported here tested the predictions that we derived from Acheson et al. The findings show that, as predicted, manipulations aiming to affect the activation of item representations significantly impacted order memory.

Generating usable and safe CO{sub 2} for enrichment of greenhouses from the exhaust gas of a biomass heating system

Energy Technology Data Exchange (ETDEWEB)

Dion, L.M.; Lefsrud, M. [McGill Univ., Macdonald Campus, Ste-Anne-deBellevue, PQ (Canada). Dept. of Bioresource Engineering

2010-07-01

This study demonstrated the use of biomass as a renewable fuel to enrich a greenhouse with carbon dioxide (CO{sub 2}). CO{sub 2} enrichment of greenhouses has been shown to improve crop production whether it occurs from liquid CO{sub 2} or combustion of fossil fuels. Biomass, in the form of wood chips or pellets, has received much interest as a sustainable and economically viable alternative to heat greenhouses. As such, the opportunity exists to convert exhaust gases from a greenhouse wood heating system into a useful resource. CO{sub 2} can be extracted from flue gas via membrane separation instead of electrostatic precipitators. This technique has shown potential for large industries trying to reduce and isolate CO{sub 2} emissions for sequestration and may be applicable to the greenhouse industry. Some research has also been done with wet scrubbers using catalysts to obtain plant fertilizers. Sulphur dioxide (SO{sub 2}) and nitrogen (NO) emissions can be stripped from flue gas to form ammonium sulphate as a valuable byproduct for fertilizer markets. This study will review the potential of these techniques in the summer of 2010 when experiments will be conducted at the Macdonald Campus of McGill University.

On the equivalence between specific adsorption and kinetic equation descriptions of the admittance response in electrolytic cells.

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Evangelista, Luiz Roberto; Lenzi, Ervin Kaminski; Barbero, Giovanni; Macdonald, James Ross

2013-03-21

The response of an electrolytic cell, in the shape of a slab, is analyzed in the framework of the Poisson-Nernst-Planck model in the limit of full dissociation. Two different types of boundary conditions on the electrodes are compared. One type describes the exchange of charges between the volume and the external circuit, in the form originally proposed by Chang and Jaffé and later extended to include specific adsorption, where the surface current density is proportional to the variation of the surface bulk density of ions with respect to the value of equilibrium. The other one describes the surface adsorption, in the limit of Langmuir. We show that in the simple case where the ions dissolved in the insulating liquid are identical in all the aspects, except for the sign of the charge, the two models are equivalent only if the phenomenological parameter entering the boundary condition of the Chang-Jaffé model, κ, is frequency dependent, and related to the adsorption coefficient, k(a), in the form κ = iωτ/(1 + iωτ)k(a), where τ is the desorption time and ω the circular frequency of the applied voltage, as proposed long ago by Macdonald.

Bimetric Theory of Fractional Quantum Hall States

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Gromov, Andrey; Son, Dam Thanh

2017-10-01

We present a bimetric low-energy effective theory of fractional quantum Hall (FQH) states that describes the topological properties and a gapped collective excitation, known as the Girvin-Macdonald-Platzman (GMP) mode. The theory consists of a topological Chern-Simons action, coupled to a symmetric rank-2 tensor, and an action à la bimetric gravity, describing the gapped dynamics of a spin-2 mode. The theory is formulated in curved ambient space and is spatially covariant, which allows us to restrict the form of the effective action and the values of phenomenological coefficients. Using bimetric theory, we calculate the projected static structure factor up to the k6 order in the momentum expansion. To provide further support for the theory, we derive the long-wave limit of the GMP algebra, the dispersion relation of the GMP mode, and the Hall viscosity of FQH states. The particle-hole (PH) transformation of the theory takes a very simple form, making the duality between FQH states and their PH conjugates manifest. We also comment on the possible applications to fractional Chern insulators, where closely related structures arise. It is shown that the familiar FQH observables acquire a curious geometric interpretation within the bimetric formalism.

Bimetric Theory of Fractional Quantum Hall States

Directory of Open Access Journals (Sweden)

Andrey Gromov

2017-11-01

Full Text Available We present a bimetric low-energy effective theory of fractional quantum Hall (FQH states that describes the topological properties and a gapped collective excitation, known as the Girvin-Macdonald-Platzman (GMP mode. The theory consists of a topological Chern-Simons action, coupled to a symmetric rank-2 tensor, and an action à la bimetric gravity, describing the gapped dynamics of a spin-2 mode. The theory is formulated in curved ambient space and is spatially covariant, which allows us to restrict the form of the effective action and the values of phenomenological coefficients. Using bimetric theory, we calculate the projected static structure factor up to the k^{6} order in the momentum expansion. To provide further support for the theory, we derive the long-wave limit of the GMP algebra, the dispersion relation of the GMP mode, and the Hall viscosity of FQH states. The particle-hole (PH transformation of the theory takes a very simple form, making the duality between FQH states and their PH conjugates manifest. We also comment on the possible applications to fractional Chern insulators, where closely related structures arise. It is shown that the familiar FQH observables acquire a curious geometric interpretation within the bimetric formalism.

REST-MapReduce: An Integrated Interface but Differentiated Service

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Jong-Hyuk Park

2014-01-01

Full Text Available With the fast deployment of cloud computing, MapReduce architectures are becoming the major technologies for mobile cloud computing. The concept of MapReduce was first introduced as a novel programming model and implementation for a large set of computing devices. In this research, we propose a novel concept of REST-MapReduce, enabling users to use only the REST interface without using the MapReduce architecture. This approach provides a higher level of abstraction by integration of the two types of access interface, REST API and MapReduce. The motivation of this research stems from the slower response time for accessing simple RDBMS on Hadoop than direct access to RDMBS. This is because there is overhead to job scheduling, initiating, starting, tracking, and management during MapReduce-based parallel execution. Therefore, we provide a good performance for REST Open API service and for MapReduce, respectively. This is very useful for constructing REST Open API services on Hadoop hosting services, for example, Amazon AWS (Macdonald, 2005 or IBM Smart Cloud. For evaluating performance of our REST-MapReduce framework, we conducted experiments with Jersey REST web server and Hadoop. Experimental result shows that our approach outperforms conventional approaches.

BOOK REVIEW: New Understanding Physics for Advanced Level

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Breithaupt, Jim

2000-09-01

Breithaupt's new book is big: at 727 pages, it will be a hefty addition to any student's bag. According to the preface, the book is designed to help students achieve the transition from GCSE to A-level and to succeed well at this level. It also aims to cover the requirements of the compulsory parts of all new syllabuses and to cover most of the optional material, too. The book is organized into seven themes along traditional lines: mechanics, materials, fields, waves, electricity, inside the atom, and physics in medicine. Each theme begins with a colourful title page that outlines what the theme is about, lists the applications that students will meet in their reading, identifies prior learning from GCSE and gives a checklist of what students should be able to do once they have finished their reading of the theme. This is all very useful. The text of the book is illustrated with many colourful photographs, pictures and cartoons, but despite this it looks very dense. There are a lot of words on every page in a small font that makes them seem very unfriendly, and although the book claims to be readable I rather doubt that the layout will encourage voluntary reading of the text. Each chapter ends with a useful summary and a selection of short questions that allow students to test their understanding. Each theme has a set of multiple choice and long questions. Some of the questions have an icon referring the student to the accompanying CD (more of this later). There is much up-to-date material in the book. For example, the section on cosmology gives a brief description of the inflationary scenario within the Big Bang model of the origin of the universe, although no mechanism for the inflation is given, which might prove unsatisfying to some students. I do have some reservations about the presentation of some topics within the book: the discussion of relativistic mass, for example, states that `Einstein showed that the mass ... is given by the formula ...' and quotes

Modelling the adoption of industrial cogeneration in Japan using manufacturing plant survey data

International Nuclear Information System (INIS)

Bonilla, David; Akisawa, Atsushi; Kashiwagi, Takao

2003-01-01

Electric power deregulation in Japan opens opportunity for further penetration of on-site generation (cogeneration) otherwise known as distributed generation. In the paper the authors present a survey on Japanese industrial plants to fill existing gaps for the assessment of modern cogeneration (combined heat and power, CHP). The objective of the paper is to empirically examine CHP systems based on cross-sectional binary models; second to review diffusion trends of CHP by system vintage during the 1980-2000 period in the manufacturing sector. The econometric results point that the probabilities of embracing this technology increase, in declining importance, with on-site power consumption, and steam demand, operational hours as well as with payback period, purchased power. For example the survey shows that the CHP is used for the purpose of exporting power rather than meeting the plant's own consumption. Some of our results are in line with those of Dismukes and Kleit (Resource Energy Econ. 21 (1999) 153) as well with Rose and Macdonald (Energy J. 12(12) (1991) 47). We also find that a unit increase in satisfaction with CHP will lead to a 54% in CHP capacity. We find significant evidence on the cost effectiveness of CHP under conservative assumptions. Regarding the influence of satisfaction and performance indicators for the several plants, the survey threw some unexpected evidence on the nature of CHP

Does reservoir host mortality enhance transmission of West Nile virus?

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Foppa Ivo M

2007-05-01

Full Text Available Abstract Background Since its 1999 emergence in New York City, West Nile virus (WNV has become the most important and widespread cause of mosquito-transmitted disease in North America. Its sweeping spread from the Atlantic to the Pacific coast was accompanied by widespread mortality among wild birds, especially corvids. Only sporadic avian mortality had previously been associated with this infection in the Old World. Here, we examine the possibility that reservoir host mortality may intensify transmission, both by concentrating vector mosquitoes on remaining hosts and by preventing the accumulation of "herd immunity". Results Inspection of the Ross-Macdonald expression of the basic reproductive number (R0 suggests that this quantity may increase with reservoir host mortality. Computer simulation confirms this finding and indicates that the level of virulence is positively associated with the numbers of infectious mosquitoes by the end of the epizootic. The presence of reservoir incompetent hosts in even moderate numbers largely eliminated the transmission-enhancing effect of host mortality. Local host die-off may prevent mosquitoes to "waste" infectious blood meals on immune host and may thus facilitate perpetuation and spread of transmission. Conclusion Under certain conditions, host mortality may enhance transmission of WNV and similarly maintained arboviruses and thus facilitate their emergence and spread. The validity of the assumptions upon which this argument is built need to be empirically examined.

Validation of Simplified Urban-Canopy Aerodynamic Parametrizations Using a Numerical Simulation of an Actual Downtown Area

Science.gov (United States)

Ramirez, N.; Afshari, Afshin; Norford, L.

2018-02-01

A steady-state Reynolds-averaged Navier-Stoke computational fluid dynamics (CFD) investigation of boundary-layer flow over a major portion of downtown Abu Dhabi is conducted. The results are used to derive the shear stress and characterize the logarithmic region for eight sub-domains, where the sub-domains overlap and are overlaid in the streamwise direction. They are characterized by a high frontal area index initially, which decreases significantly beyond the fifth sub-domain. The plan area index is relatively stable throughout the domain. For each sub-domain, the estimated local roughness length and displacement height derived from CFD results are compared to prevalent empirical formulations. We further validate and tune a mixing-length model proposed by Coceal and Belcher (Q J R Meteorol Soc 130:1349-1372, 2004). Finally, the in-canopy wind-speed attenuation is analysed as a function of fetch. It is shown that, while there is some room for improvement in Macdonald's empirical formulations (Boundary-Layer Meteorol 97:25-45, 2000), Coceal and Belcher's mixing model in combination with the resolution method of Di Sabatino et al. (Boundary-Layer Meteorol 127:131-151, 2008) can provide a robust estimation of the average wind speed in the logarithmic region. Within the roughness sublayer, a properly parametrized Cionco exponential model is shown to be quite accurate.

HISTORIOGRAPHIES ET FÉDÉRALISME AU CANADA

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Xavier Dionne

2009-10-01

Full Text Available This article studies the historical representation of the two main national communities in Canada; that is, the English-Canadian and the French-Canadian.Throughout the history of the English Canadian community, one cansee an ambitious national project. The national construction of Canada suggests the existence of a neutral model of government but, when looking at this carefully, it is possible to see something quite different. English-speaking historians from Canada have normally introduced the concept of a unitary federalism as the most perfect form of the Canadian integration project. This integrating federalism, that does not lead to emancipation, stems from thecentralist views of John Macdonald, one of the fathers of Canadian federalism. This approach has been kept for over 140 years of common history and, to this date, continues to be one of the main obstacles for minority nations within Canada. To strengthen their thesis, the authors base their work on an extensive analysis exploring the three big strategies used by the central government to assert its authority on the member States of the Canadian Federation in the long term: using the judicial power, centralizing powers andglobalization. The strategies used have varied depending on the economic scenario, political leaders and the political power relations regarding the links between the Federation and the provinces.

Peer- and Coach-Created Motivational Climates in Youth Sport: Implications for Positive Youth Development of Disadvantaged Girls

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Hebe Schaillée

2017-06-01

Full Text Available The relationship between coach- and peer-created motivational climates and Positive Youth Development is largely unexplored. This is especially true for the latter and in particular with regard to disadvantaged girls. The present study was designed to examine the relationships between perceived coach- and peer-created climates and reported developmental gains among disadvantaged girls participating in sports programmes, and to determine whether these relationships were moderated by personal characteristics. Two hundred young women aged between 12 and 22 completed a questionnaire which included the ‘Youth Experience Survey for Sport’ (MacDonald, Côté, Eys, & Deakin, 2012, the ‘Motivational Climate Scale for Youth Sports’ (Smith, Cumming, & Smoll, 2008, the ‘Peer Motivational Climate in Youth Sport Questionnaire’ (Ntoumanis & Vazou, 2005, and questions regarding participants’ socio-economic characteristics. Multilevel regression analyses were performed to take into account the hierarchical data structure. The analysis revealed that a mastery-oriented coach climate is a very strong predictor of perceived Positive Youth Development. This is based on both the number of developmental domains on which it had a significant impact and the explained variance based on the PRV values of the multi-level models. Unlike previous research on disadvantaged youth in general and disadvantaged girls in particular, the observed interaction effects did not show that disadvantaged girls necessarily gain more from their involvement in organised activities such as sport.

Extended abstracts from the eight international meeting on progress in radio-oncology (ICRO/OeGRO 8), Salzburg, May 16-19, 2007

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-12-15

This part of the journal includes 25 extended abstracts from the Eight International Meeting on Progress in Radio-Oncology ICRO/OeGRO8 in Salzburg, Austria (May 16-19, 2007): adaptive radiotherapy of prostate cancer; homoradiation of prostate cancer; radiation therapy, chemotherapy and combined chemoradiation in the management of malignant glioma; return of high-dose per fraction radiotherapy: paradigm change, lesson from the past; from bench to bedside: enhancing the effects of radiotherapy through biological escalation; gastric cancer: MAGIC or Macdonald; analysis of set-up errors in 70 consecutive patients treated for rectal carcinoma; molecular targeted therapy; teleradiooncology: telematics applications in therapeutic radiology and oncology; in-room guidance technologies for adaptive radiotherapy; dose escalation with photons - emerging technologies; late side-effects after pelvic irradiation; a frameless robotic stereotactic system for highly focused extracranial radiotherapy; altered fractionation in head and neck tumors: an alternative to chemotherapy; integration of molecular targeting with radiotherapy; OGRT pf prostate cancer patients based on CBCT and kV images; hyperfractionation in medulloblastoma; re-irradiation of recurrent prostate cancer; dose reduction of radiotherapy in early-stage testicular semimoma; photons versus protons; randomized clinical trials on postoperative radiotherapy for high-risk head and neck cancer; cardiac risk in multimodal breast cancer treatment; the use of hyperthermia treatment planning in clinical practice; presentation of the ICRU-IAEA Joint Report 'prescribing, recording, and reporting proton-beam therapy'.

Competitive mothering and delegated care: Class relationships in nanny and au pair employment

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Rosie Cox

2011-07-01

Full Text Available This paper uses the idea of 'competitive care' to explore how the mothering projects of nanny and au pair employers and the carers they employ can become inter-twined and yet may also be in conflict or competition. The paper draws on work by Cameron Lynne Macdonald (2010 and Joan Tronto (2006 to make two arguments about the inter-twining of current practices of competitive mothering and the employment of nannies and au pairs. First, practices of competitive mothering can underpin the demand for paid, privatized care in the home (such as nannies and au pairs and involve middle class / advantaged women using their position to raise their children in ways which are specifically designed to ensure and enhance their children's future social status and income. This can be at the cost of the mothering projects (and children of the women they employ. Second, one factor which underlies the prevalence of competitive mothering within certain middle class families is the conflict that working mothers feel about their roles and their strong desire to address these conflicts by showing that their children do not suffer because of their employment. The emphasis on care for children as mothering, rather than parenting – or better still 'care' – underpins this sense of conflict. The idea that it is mothers, rather than parents or society at large, who are delegating care is an important element in the organisation of care, and the relationships with carers that ensue.

What Klein’s semantic gradient does and does not really show: decomposing Stroop interference into task and informational conflict components

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Yulia eLevin

2016-02-01

Full Text Available The present study suggests that the idea that Stroop interference originates from multiple components may gain theoretically from integrating two independent frameworks. The first framework is represented by the well-known notion of semantic gradient of interference and the second one is the distinction between two types of conflict – the task and the informational conflict – giving rise to the interference (Goldfarb & Henik, 2007; McLeod & MacDonald, 2000. The proposed integration led to the conclusion that two (i.e., orthographic and lexical components of the four theoretically distinct components represent task conflict, and the other two (i.e., indirect and direct informational conflict components represent informational conflict. The four components were independently estimated in a series of experiments. The results confirmed the contribution of task conflict (estimated by a robust orthographic component and of informational conflict (estimated by a strong direct informational conflict component to Stroop interference. However, the performed critical review of the relevant literature (see General Discussion, as well as the results of the experiments reported, showed that the other two components expressing each type of conflict (i.e., the lexical component of task conflict and the indirect informational conflict were small, and unstable. The present analysis refines our knowledge of the origins of Stroop interference by providing evidence that each type of conflict has its major and minor contributions. The implications for cognitive control of an automatic reading process are also discussed.

Influences of selective adaptation on perception of audiovisual speech

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Dias, James W.; Cook, Theresa C.; Rosenblum, Lawrence D.

2016-01-01

Research suggests that selective adaptation in speech is a low-level process dependent on sensory-specific information shared between the adaptor and test-stimuli. However, previous research has only examined how adaptors shift perception of unimodal test stimuli, either auditory or visual. In the current series of experiments, we investigated whether adaptation to cross-sensory phonetic information can influence perception of integrated audio-visual phonetic information. We examined how selective adaptation to audio and visual adaptors shift perception of speech along an audiovisual test continuum. This test-continuum consisted of nine audio-/ba/-visual-/va/ stimuli, ranging in visual clarity of the mouth. When the mouth was clearly visible, perceivers “heard” the audio-visual stimulus as an integrated “va” percept 93.7% of the time (e.g., McGurk & MacDonald, 1976). As visibility of the mouth became less clear across the nine-item continuum, the audio-visual “va” percept weakened, resulting in a continuum ranging in audio-visual percepts from /va/ to /ba/. Perception of the test-stimuli was tested before and after adaptation. Changes in audiovisual speech perception were observed following adaptation to visual-/va/ and audiovisual-/va/, but not following adaptation to auditory-/va/, auditory-/ba/, or visual-/ba/. Adaptation modulates perception of integrated audio-visual speech by modulating the processing of sensory-specific information. The results suggest that auditory and visual speech information are not completely integrated at the level of selective adaptation. PMID:27041781

Perspectives on industry restructuring

International Nuclear Information System (INIS)

Konow, H. R.

1996-01-01

An industry association perspective on restructuring in the electrical industry was offered, placing the ongoing debate about deregulation and competition in the industry in Ontario into a Canadian and a global context. It was found that the move towards deregulation was a global phenomenon, fuelled by the emergence of increasingly open and highly competitive global markets, heightened consumer expectations, and new technologies and convergence. Examples from the U.K., Norway, Australia, New Zealand and the United States were cited to indicate the spread of this trend. Canadian utilities, among them B.C. Hydro, Nova Scotia Power and the Alberta utilities being prime examples, also have restructured recently into separate generation, transmission, distribution and consumer service units to better react to changing market needs. Alliances with other utilities or competitors in the energy sector to pursue business opportunities outside traditional markets, are also not uncommon. Therefore, it was only a question of time for Ontario Hydro, the largest Canadian electric utility, to come under public pressure to follow the national and global trend. The MacDonald Committee recommendations provide the foundation for radical change for the industry. If and when implemented, they could have a major impact on how the electricity sector in Canada will operate in the years to come. Sound decisions by the Ontario government as to the appropriate regulatory model may also determine the province's ability to compete in the unfolding restructuring of electricity markets throughout North America

Observations on stake holder confidence related to uranium mine waste management in the elliot lake region

International Nuclear Information System (INIS)

MacDonald, G.

2003-01-01

G. MacDonald, representing the Township of the North Shore and the Standing Environmental Committee (SEC) of the Serpent River Watershed, stated that she is a stakeholder living downstream from 175 million tonnes of acid-generating and radioactive uranium mine tailings. Public confidence in the Elliot Lake region is influenced by past mining issues: worker health concerns and difficulties in obtaining compensation; myriad observations of radium uptake; drinking water contamination issues and inequitable quality standards adverse to the Serpent River First Nation; loss of land use. Government failed to set aside funds for local monitoring of the decommissioned mining region, or to involve citizens in decisions as recommended by the Kirkwood Panel. These failures represent betrayals of trust and furthermore give public confidence little chance to improve. In these circumstances, the affected community has given attention on their own to mid- and long-term issues. At issue is not the current funding or management of the waste storage sites, but rather, creating and maintaining local knowledge and competence to monitor their management over the coming decades and generations. Concerned members of the community note that the federal government 'has done nothing long-lasting to ensure confidence', on this level. They highlight the importance of questions like: 'Do I have the knowledge to act in my best interest?' and 'Who can I trust to protect my interest?' - and have set out to answer them. (author)

Opening keynote

International Nuclear Information System (INIS)

Rae, B.

1997-01-01

In his opening address, the former premier of Ontario summarized the background of the Macdonald Committee which was appointed by his government after it became increasingly apparent that the infrastructure of Hydro Ontario was far bigger than the province and the economy could afford, and that the service that had once given Ontario tremendous competitive advantage, in the form of relatively cheap electric power, had become unsustainable in an era of economic downturn and zero inflation. He stated that the debate about Hydro is part of a broader issue, and it is no longer possible to manage our electricity system as if we were a self-enclosed universe. He predicted that the North American electricity grid will become increasingly interdependent, and that Hydro will have to develop competitive price structures, both to hold its domestic market share and to compete for export sales. He outlined the most pressing issues for Hydro as being debt reduction, while pursuing internal changes to make the organization more efficient. Organizational changes such as the creation of Ontario Hydro International, Ontario Hydro Research, separation of generation operations from the grid, and establishment of separate price and efficiency targets for the autonomous organizations within the utility family, were moves in the right direction. Equally important is to make sure that however Hydro might develop in the future, it is going to be fair to customers, and that the billions of dollars invested in Hydro by Ontario taxpayers over the years, are safeguarded

Effect of chemotherapy on malaria transmission among Yanomami Amerindians: simulated consequences of placebo treatment.

Science.gov (United States)

Freeman, J; Laserson, K F; Petralanda, I; Spielman, A

1999-05-01

To determine whether chemotherapy effectively reduces Plasmodium falciparum malaria transmission in isolated human populations, we followed two abrupt sequential outbreaks of malaria infection among Yanomami Amerindians and modeled the effect of chemotherapy and the consequences if no drug was available. A Macdonald-type mathematical model demonstrated that both outbreaks comprised a single epidemic event linked by an invisible outbreak in vector mosquitoes. The basic reproductive number, R0, from fitted values based on the treated epidemic was 2 during the initial phase of the epidemic, and waned as vector density decreased with the onset of the dry season. In the observed epidemic, 60 (45%) of 132 village residents were affected, and the treated outbreak ended after two months. Although the initial chemotherapy regimen was only marginally effective, the duration of human infectivity was reduced from an expected nine months to two weeks. In the absence of this intervention, the initial R0 value would have been 40, more than 60% of the population would have been infected, and more than 30% would have remained parasitemic until the next rainy season (about six months later). Another outbreak would then have ensued, and malaria probably would have remained endemic in this village. Our simulated placebo treatment permits us to conclude that even partially effective chemotherapeutic interventions, such as those in our study, interrupt serial transmission of P. falciparum among isolated human populations that are exposed to infection seasonally.

Vectorial capacity and vector control: reconsidering sensitivity to parameters for malaria elimination.

Science.gov (United States)

Brady, Oliver J; Godfray, H Charles J; Tatem, Andrew J; Gething, Peter W; Cohen, Justin M; McKenzie, F Ellis; Perkins, T Alex; Reiner, Robert C; Tusting, Lucy S; Sinka, Marianne E; Moyes, Catherine L; Eckhoff, Philip A; Scott, Thomas W; Lindsay, Steven W; Hay, Simon I; Smith, David L

2016-02-01

Major gains have been made in reducing malaria transmission in many parts of the world, principally by scaling-up coverage with long-lasting insecticidal nets and indoor residual spraying. Historically, choice of vector control intervention has been largely guided by a parameter sensitivity analysis of George Macdonald's theory of vectorial capacity that suggested prioritizing methods that kill adult mosquitoes. While this advice has been highly successful for transmission suppression, there is a need to revisit these arguments as policymakers in certain areas consider which combinations of interventions are required to eliminate malaria. Using analytical solutions to updated equations for vectorial capacity we build on previous work to show that, while adult killing methods can be highly effective under many circumstances, other vector control methods are frequently required to fill effective coverage gaps. These can arise due to pre-existing or developing mosquito physiological and behavioral refractoriness but also due to additive changes in the relative importance of different vector species for transmission. Furthermore, the optimal combination of interventions will depend on the operational constraints and costs associated with reaching high coverage levels with each intervention. Reaching specific policy goals, such as elimination, in defined contexts requires increasingly non-generic advice from modelling. Our results emphasize the importance of measuring baseline epidemiology, intervention coverage, vector ecology and program operational constraints in predicting expected outcomes with different combinations of interventions. © The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

Dynamics of hydrocarbon vents: Focus on primary porosity

Science.gov (United States)

Johansen, C.; Shedd, W.; Abichou, T.; Pineda-Garcia, O.; Silva, M.; MacDonald, I. R.

2012-12-01

This study investigated the dynamics of hydrocarbon release by monitoring activity of a single vent at a 1215m deep site in the Gulf of Mexico (GC600). An autonomous camera, deployed by the submersible ALVIN, was programmed to capture a close-up image every 4 seconds for approximately 3.5 hours. The images provided the ability to study the gas hydrate outcrop site (that measured 5.2x16.3cm3) in an undisturbed state. The outcrop included an array of 38 tube-like vents through which dark brown oil bubbles are released at a rate ranging from 8 bubbles per minute to 0 bubbles per minute. The average release of bubbles from all the separate vents was 59.5 bubbles per minute, equating the total volume released to 106.38cm per minute. The rate of bubble release decreased toward the end of the observation interval, which coincided approximately with the tidal minimum. Ice worms (Hesiocaeca methanicola, Desbruyères & Toulmond, 1998) were abundant at the vent site. The image sequence showed the ice-worms actively moving in and out of burrows in the mound. It has been speculated that Hesiocaeca methanicola contribute to gas hydrate decomposition by creating burrows and depressions in the gas hydrate matrix (Fisher et al, 2000). Ice worm burrows could generate pathways for the passage of oil and gas through the gas hydrate mound. Gas hydrates commonly occur along active and/or passive continental margins (Kennicutt et al, 1988a). The release of oil and gas at this particular hydrocarbon seep site is along a passive continental margin, and controlled primarily by active salt tectonics as opposed to the movement of continental tectonic plates (Salvador, 1987). We propose a descriptive model governing the release of gas and oil from deep sub-bottom reservoirs at depths of 3000-5000m (MacDonald, 1998), through consolidated and unconsolidated sediments, and finally through gas hydrate deposits at the sea floor. The oil and gas escape from the source rock and/or reservoir through

A conceptual framework for an ecosystem services-based assessment of the so-called "emergency stabilization" measures following wildfire

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Valente, Sandra; Prats, Sergio; Ribeiro, Cristina; Verheijen, Frank; Fleskens, Luuk; Keizer, Jacob

2015-04-01

-fire emergency stabilization measure, taking full stock of the field trials by Prats et al. (2012, 2013, 2014) and using existing literature to identify gaps in the data collected by Prats et al. and/or knowledge gaps on the impacts on other ecosystem services than those directly related to overland flow and soil erosion (e.g. biomass production and carbon sequestration). Such an assessment framework will be critical in gathering information on the impacts of post-fire land management, and ultimately in providing data on the cost-benefit ratio of selected emergency stabilization measures. Prats S.A., MacDonald L.H., Monteiro M., Ferreira A.J.D., Coelho C.O.A., Keizer J.J., 2012. Effectiveness of forest residue mulching in reducing post-fire runoff and erosion in a pine and a eucalypt plantation in north-central Portugal. Geoderma 191, 115-125. Prats S.A., Malvar, M.C., Vieira, D.C.S,, MacDonald L.H., Keizer J.J., 2013 (in press. Effectiveness of hydro-mulching to reduce runoff and erosion in a recently burnt pine plantation in central Portugal Land Degradation & Development (http://dx.doi.org/10.1002/ldr.2236) Prats S.A., Martins, M.A.S., Malvar, M.C., Ben-Hur, M., Keizer, J.J., 2014. Polyacrylamide application versus forest residue mulching for reducing post-fire runoff and soil erosion. Science of the Total Environment 468-469, 464-474

Review: Ina-Maria Greverus, Sharon MacDonald, Regina Romhild, Gisela Welz & Helena Wullf (Eds. (2002. Stability Upon Shifting Ground: Review Note of Shifting Grounds: Experiments in Doing Ethnography

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Robin M. Boylorn

2005-09-01

Full Text Available This review is written in response to "Shifting Grounds: Experiments in Doing Ethno­graphy," a volume of the Anthropological Journal on European Cultures. This review cites the history and implications of ethnography as a methodology within various academic disciplines while praising the authors within this text for their contributions to various ways of "doing ethnography." By investi­gating and considering the body as an ethno­graphic site where life and stories are performed and em­bodied, this article considers the varying ways the authors respond to experimental and performative ethnography while applying it to relevant and current issues within anthropology. By engaging both the anthropological and historical turn of ethnography, this book thematically discusses the mobility of fieldwork, time, space, multi-locality, tour­ism, and tradition/culture. Shifting Grounds does not only offer experiments in doing ethnography, it also offers alternatives for doing ethnography. URN: urn:nbn:de:0114-fqs0503175

Pitfalls in the Neuroimaging of Glioblastoma in the Era of Antiangiogenic and Immuno/Targeted Therapy - Detecting Illusive Disease, Defining Response

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Raymond Yi-Kun Huang

2015-02-01

Full Text Available Glioblastoma, the most common malignant primary brain tumor in adults is a devastating diagnosis with an average survival of 14-16 months using the current standard of care treatment. The determination of treatment response and clinical decision making is based on the accuracy of radiographic assessment. Notwithstanding, challenges exist in the neuroimaging evaluation of patients undergoing treatment for malignant glioma.Differentiating treatment response from tumor progression is problematic and currently combines long-term follow-up using standard MRI, with clinical status and corticosteroid-dependency assessments. In the clinical trial setting, treatment with gene therapy, vaccines, immunotherapy, and targeted biologicals similarly produces MRI changes mimicking disease progression. A neuroimaging method to clearly distinguish between pseudoprogression and tumor progression has unfortunately not been found to date. With the incorporation of antiangiogenic therapies, a further pitfall in imaging interpretation is pseudoresponse. The Macdonald Criteria that correlate tumor burden with contrast enhanced imaging proved insufficient and misleading in the context of rapid blood brain barrier normalization following antiangiogenic treatment that is not accompanied by expected survival benefit. Even improved criteria, such as the RANO criteria, that incorporate non-enhancing disease, clinical status, and need for corticosteroid use, fall short of definitively distinguishing tumor progression, pseudoresponse, and pseudoprogression.This review focuses on advanced imaging techniques including perfusion MRI, diffusion MRI, MR spectroscopy, and new PET imaging tracers. The relevant image analysis algorithms and interpretation methods of these promising techniques are discussed in the context of determining response and progression during treatment of glioblastoma both in the standard of care as well as clinical trial context.

Electrodynamics of the event horizon

International Nuclear Information System (INIS)

Punsly, B.; Coroniti, F.V.

1989-01-01

This paper is an investigation of the electrodynamics of the event horizon of a Kerr black hole. It is demonstrated that the event horizon behaves quite generally as an asymptotic vacuum infinity for axisymmetric, charge-neutral, accreting electromagnetic sources. This is in contrast with the general notion that the event horizon can be treated as an imperfect conductive membrane with a surface impedance of 4π/c. The conductive-membrane model has been incorporated into the more sophisticated membrane paradigm of Thorne, Price, and Macdonald by supplementing the model with the full equations of general relativity. In certain situations (in particular those of astrophysical interest), the conductive-membrane interpretation forms the appropriate set of pictures and images in the membrane paradigm. In this paper we reevaluate the specific gedanken experiments that were originally used to motivate the paradigm. We find that great care must be exercised if the detailed interaction of a black hole's external gravitational field with a magnetized plasma is modeled by the electrodynamics of the conductive horizon membrane. For ingoing flows of plasma or electromagnetic waves (when the hole is passively accepting information), the interpretation of the horizon as a vacuum infinity is equivalent to an imperfect conductor with a surface impedance of 4π/c (the impedance of the vacuum). In situations when an imperfect conductor should radiate information (such as a Faraday wheel) the event horizon cannot, since it is an infinity. The event horizon does not behave quite generally as an imperfect conductor, but has electrodynamic properties unique to itself

Assessing the impacts of Saskatchewan's minimum alcohol pricing regulations on alcohol-related crime.

Science.gov (United States)

Stockwell, Tim; Zhao, Jinhui; Sherk, Adam; Callaghan, Russell C; Macdonald, Scott; Gatley, Jodi

2017-07-01

Saskatchewan's introduction in April 2010 of minimum prices graded by alcohol strength led to an average minimum price increase of 9.1% per Canadian standard drink (=13.45 g ethanol). This increase was shown to be associated with reduced consumption and switching to lower alcohol content beverages. Police also informally reported marked reductions in night-time alcohol-related crime. This study aims to assess the impacts of changes to Saskatchewan's minimum alcohol-pricing regulations between 2008 and 2012 on selected crime events often related to alcohol use. Data were obtained from Canada's Uniform Crime Reporting Survey. Auto-regressive integrated moving average time series models were used to test immediate and lagged associations between minimum price increases and rates of night-time and police identified alcohol-related crimes. Controls were included for simultaneous crime rates in the neighbouring province of Alberta, economic variables, linear trend, seasonality and autoregressive and/or moving-average effects. The introduction of increased minimum-alcohol prices was associated with an abrupt decrease in night-time alcohol-related traffic offences for men (-8.0%, P prices may contribute to reductions in alcohol-related traffic-related and violent crimes perpetrated by men. Observed lagged effects for violent incidents may be due to a delay in bars passing on increased prices to their customers, perhaps because of inventory stockpiling. [Stockwell T, Zhao J, Sherk A, Callaghan RC, Macdonald S, Gatley J. Assessing the impacts of Saskatchewan's minimum alcohol pricing regulations on alcohol-related crime. Drug Alcohol Rev 2017;36:492-501]. © 2016 Australasian Professional Society on Alcohol and other Drugs.

Kansas State University accelerator laboratory upgrade

International Nuclear Information System (INIS)

Richard, P.

1989-01-01

The J.R. Macdonald Laboratory is undergoing a major upgrade of its facilities and capabilities. The laboratory is dedicated to the study of ion-atom collisions using highly charged ions from accelerators and/or ion sources. The mainstay of the laboratory over the last two decades has been a 6 MV tandem accelerator. It has been used to produce one- to a few-MeV/u highly charged ions for studying high energy atomic collisions, and to produce recoil ions from ocllisions with projectile ions for studying low energy atomic collisions. In order to enhance the capabilities of studying atomic collisions in these two energy regimes, we are constructing a superconducting LINAC booster to the tandem, and a stand-alone CRYEBIS source. The project, which is funded by the US Department of Energy, began in May 1985 with a May 1989 completion schedule. The upgrade includes a building addition, funded by the State of Kansas, to house the new facilities. The LINAC consists of a time-superbunching module, followed by three large cryostat modules each containing four superconducting resonators, and followed by an energy-rebunching module. The resonators are the split-ring superconducting Nb type designed and constructed at Argonne National Laboratory, and are presently being tested at KSU. The CRYEBIS source, which consists of a 1 m long 5 T superconducting solenoid with a high degree of straightness, is in the final stages of assembly. We have in operation a new computer network for data acquisition and analysis. A progress report on the status of the upgrade is presented. (orig.)

The conceptualization of childhood in North American pediatric dentistry texts: a discursive case study analysis.

Science.gov (United States)

Makansi, Nora; Carnevale, Franco A; Macdonald, Mary Ellen

2018-03-01

In recent years, conceptions of childhood have been evolving towards an increased recognition of children as active agents, capable of participating in the determination of their wellbeing. In pediatric dentistry, the extent to which these conceptions are being discursively endorsed is not well known. The aim of this investigation was to examine the discursive construction of childhood in seminal North American pedagogical dentistry materials. We conducted a qualitative discourse analysis of a sample of prominent texts using a sociological discourse analysis approach. We analyzed the latest edition of Macdonald and Avery's textbook (Chapter: Non pharmacologic management of children's behaviors) and the clinical practice guidelines published by the American Academy of Pediatric Dentistry, AAPD (Behavior guidance for the pediatric dental patient). The analysis produced five salient discursive categories: socialization through behavior modification; development and behavior; paternalism; the utility of child-centered communication; and consequentialism. While there were instances of a child-centered focus in the texts, the main discourses were rooted in developmentalism and behaviorism. There was scant acknowledgment of the importance of children's agency or voice, which runs contrary to child-centered discourses and practices in related disciplines (e.g., pediatric medicine, nursing). Predominant discourses in pediatric dentistry suggest a paternalistic, behaviorist approach to the 'management' of children in the dental office, focused primarily on completing interventions. Priorities for the future development of pediatric dentistry are discussed, integrating more child-centered approaches. © 2017 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Magnetic Modeling of Inflated Low-mass Stars Using Interior Fields No Larger than ˜10 kG

Science.gov (United States)

MacDonald, James; Mullan, D. J.

2017-11-01

We have previously reported on models of low-mass stars in which the presence of inflated radii is ascribed to magnetic fields that impede the onset of convection. Some of our magneto-convection models have been criticized because, when they were first reported by Mullan & MacDonald, the deep interior fields were found to be very large (50-100 MG). Such large fields are now known to be untenable. For example, Browning et al. used stability arguments to suggest that interior fields in low-mass stars cannot be larger than ˜1 MG. Moreover, 3D models of turbulent stellar dynamos suggest that fields generated in low-mass interiors may be not much stronger than 10-20 kG. In the present paper, we present magneto-convective models of inflated low-mass stars in which the interior fields are not permitted to be stronger than 10 kG. These models are used to fit empirical data for 15 low-mass stars for which precise masses and radii have been measured. We show that our 10 kG magneto-convective models can replicate the empirical radii and effective temperatures for 14 of the stars. In the case of the remaining star (in the Praesepe cluster), two different solutions have been reported in the literature. We find that one of these solutions can be fitted well with our model using the nominal age of Praesepe (800 Myr). However, the second solution cannot be fitted unless the star’s age is assumed to be much younger (˜150 Myr).

Blazar Sheath Illumination of the Outer Molecular Torus: A Resolution of the Seed Photon Problem for the Far-GeV Blazar Flares

Science.gov (United States)

Breiding, Peter; Georganopoulos, Markos; Meyer, Eileen T.

2018-01-01

Recent multiwavelength work led by the Boston University blazar group (e.g., Marscher et al.) strongly suggests that a fraction of the blazar flares seen by the Fermi Large Area Telescope (LAT) take place a few to several pc away from the central engine. However, at such distances from the central engine, there is no adequate external photon field to provide the seed photons required for producing the observed GeV emission under leptonic inverse Compton (IC) models. A possible solution is a spine-sheath geometry for the emitting region (MacDonald et al., but see Nalewajko et al.). Here we use the current view of the molecular torus (e.g., Elitzur; Netzer), in which the torus extends a few pc beyond the dust sublimation radius with dust clouds distributed with a declining density for decreasing polar angle. We show that for a spine-sheath blazar jet embedded in the torus, the wide beaming pattern of the synchrotron radiation of the relatively slow sheath will heat molecular clouds with subsequent IR radiation that will be highly boosted in the spine comoving frame, and that under reasonable conditions this photon field can dominate over the sheath photons directly entering the spine. If the sheath is sufficiently luminous it will sublimate the dust, and if the sheath synchrotron radiation extends to optical-UV energies (as may happen during flares), this will illuminate the sublimated dust clouds to produce emission lines that will vary in unison with the optical-UV continuum, as has been very recently reported for blazar CTA 102 (Jorstad et al.).

Consumption metrics of chardonnay wine consumers in Australia

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Saliba AJ

2015-02-01

Full Text Available Anthony J Saliba,1 Johan Bruwer,2 Jasmine B MacDonald1 1School of Psychology, Charles Sturt University, Bathurst, NSW, 2School of Marketing, University of South Australia, Adelaide, SA, Australia Abstract: There is a dearth of information in the knowledge base about who the chardonnay consumer is, what their wine-consumption metrics are, what sensory characteristics they associate chardonnay with, and who influenced their perceptions. This study examines the consumer engagement with chardonnay, and contributes evidence-based research to inform future wine-business strategy. A population sample was recruited to be representative of Australian consumers. An online survey of 2,024 Australian wine consumers was conducted, 1,533 (76% of whom actually consumed chardonnay. This paper focuses only on those who consumed chardonnay. Males purchased and consumed larger quantities of chardonnay, although marginally more females consumed it. Chardonnay is considered to be characterized by full, lingering, and fruity flavors, as well as yellow color. Chardonnay is associated with dinner parties and at-home consumption. The vast majority of participants liked and had a positive perception of chardonnay. The target market for chardonnay is not only females; in fact, males appear to be the main consumers of this varietal by volume. Marketing and promotion campaigns should leverage the findings to retain current and win back other consumers. This is the first research to provide empirical explanations of consumer engagement with chardonnay, and to contribute evidence-based research in this regard.Keywords: chardonnay, consumer behavior, wine style, wine consumption, Australia

Clinical practice guidelines: 2004 standards, options and recommendations for the management of patient with adenocarcinoma of the stomach - radiotherapy

International Nuclear Information System (INIS)

Ychou, M.; Duffour, J.; Lemanski, C.; Masson, B.; Gory-Delabaere, G.; Bosquet, L.; Blanc, P.; Giovannini, M.; Monge, G.; Guillemin, F.; Marchal, F.; Conroy, T.; Merrouche, Y.; Adenis, A.; Bosset, J.F.; Bouche, O.; Pezet, D.; Triboulet, J.P.

2004-01-01

Context. - The 'Standards, Options and Recommendations' (SOR) project, started in 1993, is a collaboration between the Federation of French Cancer Centers (FNCLCC), the 20 French regional cancer centers, and specialists from French Public Universities, General Hospitals and Private Clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients. Objectives. - To elaborate clinical practice guidelines for patients with stomach adenocarcinoma. These recommendations cover the diagnosis, treatment and follow-up of these tumors. Methods. - The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery. The Standards, Options and Recommendations are thus based on the best available evidence and expert agreement. Results. - Adjuvant radiation therapy alone is not a standard treatment for patients with stomach adenocarcinoma. Adjuvant concomitant chemoradiotherapy is not a standard treatment for patients with stage II or III stomach adenocarcinoma R0, with D1 or D2 lymphadenectomy who have undergone surgery. Following surgical resection, adjuvant concomitant chemoradiotherapy should be proposed to patients without de-nutrition with a lymphadenectomy < D1 (fewer than 15 lymph nodes examined) and those with T3 and/or N+ tumours following the protocol used in the MacDonald trials (SWOG-9008) (Level of evidence B1). Adjuvant concomitant chemoradiotherapy can be administered to patients without de-nutrition with D1 or D2 lymphadenectomy and with involvement of regional lymph nodes (N2 or N3). (authors)

What Makes a Difference for Disadvantaged Girls? Investigating the Interplay between Group Composition and Positive Youth Development in Sport

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Hebe Schaillée

2015-06-01

Full Text Available It has been suggested that group composition can influence the experiences of individual group members in social programmes (Weiss, 1998. The purpose of the present study was to examine the relationship between peer group composition in sports programmes and positive youth development (PYD in disadvantaged girls, as well as to determine whether it was moderated by personal characteristics. Two hundred young women aged between 10 and 24 completed a questionnaire including, among others, the “Youth Experience Survey for Sport” (YES-S (MacDonald, Côté, Eys, & Deakin, 2012 and questions regarding participants’ socio-economic characteristics (i.e., nationality, education, family situation. Multilevel regression analyses were performed to take into account the hierarchical data structure. At the group level, a higher percentage of girls from a low educational track and with a migration background predicted greater PYD, as indicated by higher levels of personal and social skills, cognitive skills and goal setting. Results showed interaction effects between the respondents’ family structures on the participant and team levels. The overall statistical models for the different developmental domains accounted for variance ranging from 14.7% (personal and social skills to 30.3% (cognitive skills. Results indicated that the extent to which disadvantaged girls derive benefits from their participation in sport also depends on the group composition. The interaction effects between the group composition and individual characteristics suggest that when girls participate in a group of similar peers, those from non-intact families will derive more benefits than their counterparts from intact families.

BOOK REVIEW: Key Science Physics: New Edition and Key Science Physics for International Schools: Extension File

Science.gov (United States)

Maybank, Maureen

1999-09-01

When handling , I recalled how one set of sixth-form students that I taught affectionately referred to Jim Breithaupt's large format book Understanding Physics for Advanced Level as `Big Jim'. This package, for GCSE students and teachers, is its younger brother. Key Science Physics was reviewed in this journal over four years ago. Now it is in a new edition with an expanded ring file of teacher resources (a Teacher's Guide and Extension File). It has been expanded for a wider range of students to meet the requirements of all GCSE syllabuses with additional topics for IGCSE and IB. The international bit seems to be among materials in the file of resources and does not appear in the title of the students' textbook. This is not one of those purchases that will only get occasional use and be left in a department library but it is one that contains sufficient excellent material to become central to any GCSE Physics course. For the students there is a single-volume 396-page textbook in full colour (not a heavyweight book). Marginal comments point out places where an Activity or Assignment from the Extension File fits in. All the materials in the teacher's Extension File are cross referenced to the numbering of this textbook, i.e. its Themes, Topics, Checkpoints, Tests etc, not to page numbers. The margin is used in other attractive ways to highlight a summary, propose a first thought or provide a topic summary. The text is fruitful mix of pure physics, applications and personalities. To support the students' practical work the Extension File contains photocopiable sheets. For the activities and assignments a few contain a harder version to give access to the higher levels of attainment. Four alternatives to practical questions are given; there are also exam questions and multiple choice questions for each topic. These all have helpful mark schemes on the teacher's answers pages. What else do you get? A Glossary collection of sheets to photocopy with space to enter a

Inferring the Spatio-temporal Patterns of Dengue Transmission from Surveillance Data in Guangzhou, China.

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Guanghu Zhu

2016-04-01

Full Text Available Dengue is a serious vector-borne disease, and incidence rates have significantly increased during the past few years, particularly in 2014 in Guangzhou. The current situation is more complicated, due to various factors such as climate warming, urbanization, population increase, and human mobility. The purpose of this study is to detect dengue transmission patterns and identify the disease dispersion dynamics in Guangzhou, China.We conducted surveys in 12 districts of Guangzhou, and collected daily data of Breteau index (BI and reported cases between September and November 2014 from the public health authority reports. Based on the available data and the Ross-Macdonald theory, we propose a dengue transmission model that systematically integrates entomologic, demographic, and environmental information. In this model, we use (1 BI data and geographic variables to evaluate the spatial heterogeneities of Aedes mosquitoes, (2 a radiation model to simulate the daily mobility of humans, and (3 a Markov chain Monte Carlo (MCMC method to estimate the model parameters.By implementing our proposed model, we can (1 estimate the incidence rates of dengue, and trace the infection time and locations, (2 assess risk factors and evaluate the infection threat in a city, and (3 evaluate the primary diffusion process in different districts. From the results, we can see that dengue infections exhibited a spatial and temporal variation during 2014 in Guangzhou. We find that urbanization, vector activities, and human behavior play significant roles in shaping the dengue outbreak and the patterns of its spread. This study offers useful information on dengue dynamics, which can help policy makers improve control and prevention measures.

Clinical deterioration after sildenafil cessation in patients with pulmonary hypertension

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Anne M Keogh

2008-10-01

Full Text Available Anne M Keogh, Andrew Jabbour, Christopher S Hayward, Peter S MacdonaldHeart Lung Transplant Unit, St Vincent’s Hospital, Sydney, New South Wales, AustraliaAbstract: Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE-5. Its chronic administration has been shown to improve exercise capacity, World Health Organization functional class, and haemodynamics in patients with symptomatic pulmonary arterial hypertension (PAH. There is however, no data describing the clinical consequences of sudden cessation of sildenafil treatment. In this series, 9 patients with NYHA Class II–IV PAH who were stable on 2 months of sildenafil monotherapy, had their sildenafil ceased to accommodate a 2-week washout period, required for enrollment in research involving an endothelin receptor antagonist. Six minute walk distance (SMWD and clinical assessments were performed before cessation of sildenafil, and again 2 weeks later. Over the course of this 2-week washout period, 6 of the 9 patients reported increased breathlessness and fatigue, 1 of these was hospitalized with worsening right heart failure. The SMWD fell in 6 patients, with falls of greater than 100 m recorded in 4 patients. This was accompanied by a worsening of NYHA Class from 2.5 ± 0.2 to 3.1 ± 0.1 (mean ± SEM, p = 0.01. These data indicate that sudden cessation of sildenafil monotherapy, in patients with PAH, carries with it a significant and unpredictable risk of rapid clinical deterioration. We recommend that if sildenafil needs to be ceased, it would be more prudent to consider concurrent vasodilator therapy before the gradual cessation of sildenafil.Keywords: sildenafil, pulmonary hypertension, phosphodiesterase inhibitor

Problem-Based Learning in Management Accounting Teaching: Report of a Brazilian Experience

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Daiana Bragueto Martins

2016-01-01

Full Text Available This study aimed to report on the operation of the PBL method in a management accounting discipline in the Accounting course of a Brazilian Higher Education institution. The research technique used was the case study, involving a descriptive approach to PBL classes, whose purpose was to present the properties of the classes, how to act and the profile of the students and teachers. The field research took place in 2013. The data were collected through interviews with teachers, participant observation and document analysis. The empirical analysis in this research rested on the studies by Araújo and Arantes (2009, Dochy, Segers, Bossche and Gijbels (2003, Duch, Groh and Allen (2001, MacDonald and Savin-Baden (2004, Ribeiro (2008, Schmidt (1983, Sockalingam and Schmidt (2011, among others. The results show that the integration between academics and businesses based on the use of practical and real problems the students brought from the work environment offered gains, such as: the student broadens the potential to solve practical and professional problems; and the company is benefited, as it can receive qualified professionals in the future, who are able for research and the proposal of solutions to problems. Teachers also gain as they are exposed to a contemporary setting, providing major updates in terms of use of concepts and theories, because of the contextualization. The PBL helps to engage Generation Y students, given that the desire for participation and communication in an interactive environment using technological tools are the main marks of that generation. The skills developed in the PBL approach are similar to those required from the management accountant.

Transmission dynamics of carbapenemase-producing Klebsiella pneumoniae and anticipated impact of infection control strategies in a surgical unit.

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Vana Sypsa

Full Text Available BACKGROUND: Carbapenemase-producing Klebsiella pneumoniae (CPKP has been established as important nosocomial pathogen in many geographic regions. Transmission from patient to patient via the hands of healthcare workers is the main route of spread in the acute-care setting. METHODOLOGY/PRINCIPAL FINDINGS: Epidemiological and infection control data were recorded during a prospective observational study conducted in a surgical unit of a tertiary-care hospital in Greece. Surveillance culture for CPKP were obtained from all patients upon admission and weekly thereafter. The Ross-Macdonald model for vector-borne diseases was applied to obtain estimates for the basic reproduction number R(0 (average number of secondary cases per primary case in the absence of infection control and assess the impact of infection control measures on CPKP containment in endemic and hyperendemic settings. Eighteen of 850 patients were colonized with CPKP on admission and 51 acquired CPKP during hospilazation. R(0 reached 2 and exceeded unity for long periods of time under the observed hand hygiene compliance (21%. The minimum hand hygiene compliance level necessary to control transmission was 50%. Reduction of 60% to 90% in colonized patients on admission, through active surveillance culture, contact precautions and isolation/cohorting, in combination with 60% compliance in hand hygiene would result in rapid decline in CPKP prevalence within 8-12 weeks. Antibiotics restrictions did not have a substantial benefit when an aggressive control strategy was implemented. CONCLUSIONS/SIGNIFICANCE: Surveillance culture on admission and isolation/cohorting of colonized patients coupled with moderate hand hygiene compliance and contact precautions may lead to rapid control of CPKP in endemic and hyperendemic healthcare settings.

Transmission Dynamics of Carbapenemase-Producing Klebsiella Pneumoniae and Anticipated Impact of Infection Control Strategies in a Surgical Unit

Science.gov (United States)

Sypsa, Vana; Psichogiou, Mina; Bouzala, Georgia-Aikaterina; Hadjihannas, Linos; Hatzakis, Angelos; Daikos, Georgios L.

2012-01-01

Background Carbapenemase-producing Klebsiella pneumoniae (CPKP) has been established as important nosocomial pathogen in many geographic regions. Transmission from patient to patient via the hands of healthcare workers is the main route of spread in the acute-care setting. Methodology/Principal Findings Epidemiological and infection control data were recorded during a prospective observational study conducted in a surgical unit of a tertiary-care hospital in Greece. Surveillance culture for CPKP were obtained from all patients upon admission and weekly thereafter. The Ross-Macdonald model for vector-borne diseases was applied to obtain estimates for the basic reproduction number R0 (average number of secondary cases per primary case in the absence of infection control) and assess the impact of infection control measures on CPKP containment in endemic and hyperendemic settings. Eighteen of 850 patients were colonized with CPKP on admission and 51 acquired CPKP during hospilazation. R0 reached 2 and exceeded unity for long periods of time under the observed hand hygiene compliance (21%). The minimum hand hygiene compliance level necessary to control transmission was 50%. Reduction of 60% to 90% in colonized patients on admission, through active surveillance culture, contact precautions and isolation/cohorting, in combination with 60% compliance in hand hygiene would result in rapid decline in CPKP prevalence within 8–12 weeks. Antibiotics restrictions did not have a substantial benefit when an aggressive control strategy was implemented. Conclusions/Significance Surveillance culture on admission and isolation/cohorting of colonized patients coupled with moderate hand hygiene compliance and contact precautions may lead to rapid control of CPKP in endemic and hyperendemic healthcare settings. PMID:22859965

A sub-microscopic gametocyte reservoir can sustain malaria transmission.

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Stephan Karl

Full Text Available Novel diagnostic tools, including PCR and high field gradient magnetic fractionation (HFGMF, have improved detection of asexual Plasmodium falciparum parasites and especially infectious gametocytes in human blood. These techniques indicate a significant number of people carry gametocyte densities that fall below the conventional threshold of detection achieved by standard light microscopy (LM.To determine how low-level gametocytemia may affect transmission in present large-scale efforts for P. falciparum control in endemic areas, we developed a refinement of the classical Ross-Macdonald model of malaria transmission by introducing multiple infective compartments to model the potential impact of highly prevalent, low gametocytaemic reservoirs in the population. Models were calibrated using field-based data and several numerical experiments were conducted to assess the effect of high and low gametocytemia on P. falciparum transmission and control. Special consideration was given to the impact of long-lasting insecticide-treated bed nets (LLIN, presently considered the most efficient way to prevent transmission, and particularly LLIN coverage similar to goals targeted by the Roll Back Malaria and Global Fund malaria control campaigns. Our analyses indicate that models which include only moderate-to-high gametocytemia (detectable by LM predict finite eradication times after LLIN introduction. Models that include a low gametocytemia reservoir (requiring PCR or HFGMF detection predict much more stable, persistent transmission. Our modeled outcomes result in significantly different estimates for the level and duration of control needed to achieve malaria elimination if submicroscopic gametocytes are included.It will be very important to complement current methods of surveillance with enhanced diagnostic techniques to detect asexual parasites and gametocytes to more accurately plan, monitor and guide malaria control programs aimed at eliminating malaria.

The effects of music on time perception and performance of a driving game.

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Cassidy, G G; Macdonald, R A R

2010-12-01

There is an established and growing body of evidence highlighting that music can influence behavior across a range of diverse domains (Miell, MacDonald, & Hargreaves 2005). One area of interest is the monitoring of "internal timing mechanisms", with features such as tempo, liking, perceived affective nature and everyday listening contexts implicated as important (North & Hargreaves, 2008). The current study addresses these issues by comparing the effects of self-selected and experimenter-selected music (fast and slow) on actual and perceived performance of a driving game activity. Seventy participants completed three laps of a driving game in seven sound conditions: (1) silence; (2) car sounds; (3) car sounds with self-selected music, and car sounds with experimenter-selected music; (4) high-arousal (70 bpm); (5) high-arousal (130 bpm); (6) low-arousal (70 bpm); and (7) low-arousal (130 bpm) music. Six performance measures (time, accuracy, speed, and retrospective perception of these), and four experience measures (perceived distraction, liking, appropriateness and enjoyment) were taken. Exposure to self-selected music resulted in overestimation of elapsed time and inaccuracy, while benefiting accuracy and experience. In contrast, exposure to experimenter-selected music resulted in poorest performance and experience. Increasing the tempo of experimenter-selected music resulted in faster performance and increased inaccuracy for high-arousal music, but did not impact experience. It is suggested that personal meaning and subjective associations connected to self-selected music promoted increased engagement with the activity, overriding detrimental effects attributed to unfamiliar, less liked and less appropriate experimenter-selected music. © 2010 The Authors. Scandinavian Journal of Psychology © 2010 The Scandinavian Psychological Associations.

The breakup of OPG : a suggestion for accelerating competition in generation in Ontario

International Nuclear Information System (INIS)

2003-01-01

Although wholesale and retail electricity markets in Ontario were opened to competition on May 1, 2002, the market cannot be said to be truly competitive because Ontario Power Generation (OPG) is still the dominant market participant controlling more than 25,000 MW of capacity, which gives it market power. The Association of Major Power Consumers in Ontario (AMPCO) has made specific proposals to the Macdonald Committee on how OPG could be restructured into several commercial generating companies, but it does not appear that OPG activities will be decontrolled in the next 2 or 3 years for the following 4 reasons: (1) the general state of the market for generation resource is poor following the collapse of Enron, (2) the government cannot afford to decontrol large quantities of OPG plants, (3) uncertainty over public policy regarding environmental regulations makes it difficult to decontrol fossil-fuelled plants, and (4) uncertainty over the return to service of Pickering A and Bruce A nuclear plants. Total OPG capacity is 25,855 MW including Pickering A. OPG's fossil-fuelled plants are mostly coal-fuelled and are under pressure from environmental groups to convert to gas. However, none of the plants are suitable for conversion. AMPCO strongly recommends that these plants should be operated in a commercial manner without unduly intrusive environmental regulation. Options for restructuring nuclear, fossil and large hydro plants were also presented along with a proposal to restructure OPG into multiple operating companies. It was concluded that the decontrol of OPG generation through the Market Power Mitigation Arrangement would result in a viable and liquid market, where prices are controlled by competitive forces. 2 refs., 2 tabs

Safety in numbers 4: The relationship between exposure to authentic and didactic environments and nursing students' learning of medication dosage calculation problem solving knowledge and skills.

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Weeks, Keith W; Clochesy, John M; Hutton, B Meriel; Moseley, Laurie

2013-03-01

Advancing the art and science of education practice requires a robust evaluation of the relationship between students' exposure to learning and assessment environments and the development of their cognitive competence (knowing that and why) and functional competence (know-how and skills). Healthcare education translation research requires specific education technology assessments and evaluations that consist of quantitative analyses of empirical data and qualitative evaluations of the lived student experience of the education journey and schemata construction (Weeks et al., 2013a). This paper focuses on the outcomes of UK PhD and USA post-doctorate experimental research. We evaluated the relationship between exposure to traditional didactic methods of education, prototypes of an authentic medication dosage calculation problem-solving (MDC-PS) environment and nursing students' construction of conceptual and calculation competence in medication dosage calculation problem-solving skills. Empirical outcomes from both UK and USA programmes of research identified highly significant differences in the construction of conceptual and calculation competence in MDC-PS following exposure to the authentic learning environment to that following exposure to traditional didactic transmission methods of education (p students exposure to authentic learning environments is an essential first step in the development of conceptual and calculation competence and relevant schemata construction (internal representations of the relationship between the features of authentic dosage problems and calculation functions); and how authentic environments more ably support all cognitive (learning) styles in mathematics than traditional didactic methods of education. Functional competence evaluations are addressed in Macdonald et al. (2013) and Weeks et al. (2013e). Copyright © 2012. Published by Elsevier Ltd.

Pāhoehoe, `a`ā, and block lava: an illustrated history of the nomenclature

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Harris, Andrew J. L.; Rowland, Scott K.; Villeneuve, Nicolas; Thordarson, Thor

2017-01-01

Lava flows occur worldwide, and throughout history, various cultures (and geologists) have described flows based on their surface textures. As a result, surface morphology-based nomenclature schemes have been proposed in most languages to aid in the classification and distinction of lava surface types. One of the first to be published was likely the nine-class, Italian-language description-based classification proposed by Mario Gemmellaro in 1858. By far, the most commonly used terms to describe lava surfaces today are not descriptive but, instead, are merely words, specifically the Hawaiian words `a`ā (rough brecciated basalt lava) and pāhoehoe (smooth glassy basalt lava), plus block lava (thick brecciated lavas that are typically more silicic than basalt). `A`ā and pāhoehoe were introduced into the Western geological vocabulary by American geologists working in Hawai`i during the 1800s. They and other nineteenth century geologists proposed formal lava-type classification schemes for scientific use, and most of them used the Hawaiian words. In 1933, Ruy Finch added the third lava type, block lava, to the classification scheme, with the tripartite system being formalized in 1953 by Gordon Macdonald. More recently, particularly since the 1980s and based largely on studies of lava flow interiors, a number of sub-types and transitional forms of all three major lava types have been defined. This paper reviews the early history of the development of the pāhoehoe, `a`ā, and block lava-naming system and presents a new descriptive classification so as to break out the three parental lava types into their many morphological sub-types.

Estimation of vectorial capacity of Anopheles minimus Theobald & An. fluviatilis James (Diptera: Culicidae) in a malaria endemic area of Odisha State, India.

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Gunasekaran, K; Sahu, S S; Jambulingam, P

2014-11-01

Anopheles minimus and An. fluviatilis were incriminated as the major malaria vectors in Keonjhar district of Odisha State recently. This study was carried out to elucidate the potential role of these two vector species in transmission of malaria during different seasons, and vectorial capacity of these species was also estimated. Three hilly and forested villages of Keonjhar district were randomly selected. Vectorial capacity (C) was calculated using the Macdonald's formula as modified by Garret-Jones. The human landing density of the vector species was obtained from all night human landing collections (bait protected by bed-net). Man feeding habit was estimated by multiplying the human blood index with feeding frequency, which was obtained on daily basis from the duration of gonotrophic cycle. The probability of survival through the extrinsic incubation cycle was calculated from the probability of survival through one day and duration of sporogonic cycle. The estimated vectorial capacity of An. minimus varied between 0.014 and 1.09 for Plasmodium falciparum (Pf) and between 0.1 and 1.46 for P. vivax (Pv). The C of An. minimus for both Pf and Pv was higher during rainy season than the other two seasons. The estimated C of An. fluviatilis varied between 0.04 and 1.28 for Pf and between 0.20 and 1.54 for Pv. Based on the estimated values of vectorial capacity of the two vector species, the area could be stratified and such stratification would reflect the difference in the intensity of transmission between different strata and accordingly the appropriate control strategy could be adopted for each stratum.

Resultados gestacionais e perinatais de gestações com insuficiência cervical submetidas a circlagem eletiva Gestational and perinatal outcomes of pregnancies with cervical incompetence submitted to elective cerclage

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Marcelo Luís Nomura

2003-08-01

Full Text Available OBJETIVO: descrever os resultados gestacionais de uma série de gestantes submetidas a circlagem cervical eletiva. MÉTODOS: estudo retrospectivo descritivo de 123 gestações em 116 pacientes submetidas a circlagem eletiva por insuficiência cervical, pelas técnicas de Espinosa-Bahamondes, Palmer ou MacDonald, e acompanhadas no Ambulatório de Pré-Natal Especializado do CAISM/UNICAMP. As variáveis foram analisadas por meio frequência, média e desvio-padrão e comparadas pelo teste de c² ou o teste exato de Fisher. RESULTADOS: 73% das pacientes apresentavam pelo menos um abortamento prévio, 17,9% tinham 3 ou mais abortamentos anteriores e 48% tinham antecedente de parto prematuro. A idade gestacional média de realização da circlagem foi 16 semanas. Houve predomínio de utilização da técnica cirúrgica de Espinosa modificada por Bahamondes (94,3%. A incidência de complicações durante a gestação foi de 69%; a do trabalho de parto prematuro (31,7% foi a mais freqüente, seguido de vaginites/vaginose (26%, ruptura prematura pré-termo de membranas (10,5% e óbito fetal (8,7%, As principais intercorrências clínicas associadas foram infecção do trato urinário (5,6%, síndromes hipertensivas (4% e diabete gestacional (2,4%. O índice de perdas gestacionais foi de 8,9% (11 óbitos fetais. Houve 18% de partos prematuros e o antecedente de parto prematuro associou-se à ocorrência de partos prematuros na gestação em estudo. CONCLUSÕES: os antecedentes obstétricos compatíveis com insuficiência istmocervical foram freqüentes e o antecedente de parto prematuro associou-se a ocorrência de partos prematuros na gestação em estudo. A utilização de circlagem a Espinosa-Bahamondes resultou em taxa de 18% de partos prematuros e de 104 em mil de morte perinatal. São necessários estudos prospectivos controlados para avaliar o real benefício da circlagem cervical durante a gravidez.PURPOSE: to describe the pregnancy outcome of

Experimental Investigation of the Effect of Particle Shape on Frictional Pressure drop in Particulate Debris Bed

International Nuclear Information System (INIS)

Park, Jin Ho; Kim, Eun Ho; Park, Hyun Sun

2014-01-01

To ensure the long-term cooling of corium in the reactor cavity, it is important to ensure the coolant ingression into the internally heat generated corium debris bed which is governed by pressure drop in porous media. For this reason, it is necessary to understand pressure drop mechanisms in porous bed to verify the feasibility of water penetration into particulate debris bed. According to the previous investigations on molten fuel-coolant interaction (FCI) experiments, it was found that quenched particulate debris bed was composed of irregular shape particles. Therefore, empirical or semiempirical models based on the Ergun equation (Ergun, 1952) for single-phase flow in porous media composed of single sized spherical particle were developed to consider the effect of particle shape on frictional pressure drop by means of adding a shape factor or modifying the Ergun constants etc. (Leva, 1959, Handley and Heggs, 1968, Macdonald, 1979, Foumeny et al., 1996). An experimental investigate on single-phase frictional pressure drop of water in packed bed was conducted in the transparent cylindrical test section with the inner diameter of 100 mm and the height of 700 mm to study the effect of particle shape on frictional pressure drop in porous media. This paper reports the experimental data for spherical particles with the diameter of 2 mm and 5 mm and cylindrical particles with ED of 2 mm and 5 mm. And also, the experimental data compared with the models to predict frictional pressure drop in particulate bed. The conclusions are summarized as follows. As a result of the experiment to measure frictional pressure drop in particulate bed composed of cylindrical particles the models predict the experimental data well within 22.11 % except the Handley and Heggs model when ED is applied to the models

Do breastfeeding intentions of pregnant inner-city teens and adult women differ?

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Alexander, Ashley; O'Riordan, Mary Ann; Furman, Lydia

2010-12-01

This study compared the breastfeeding intentions and attitudes of pregnant low-income inner-city teens (age ≤19 years) and non-teens (age ≥20) to determine if age is a significant determinant of intent to breastfeed in this population. We used structured interviews to examine the feeding intentions and attitudes of consecutive healthy pregnant women receiving obstetrical care at the Women's Health Center, MacDonald Women's Hospital, Cleveland, OH (June 1-July 31, 2007). The primary outcome measure was rate of intent to breastfeed among teen versus non-teen participants. Attitudes and self-assessed knowledge regarding breastfeeding were compared between teens and non-teens, and multiple logistic regression analysis was used to examine the effect of age on breastfeeding intent. We interviewed 176 pregnant women (95% African-American, 94% single marital status, median age 22 years [range, 15-41 years], 46 [26%] teens) at a median of 27 weeks of pregnancy. There were no significant differences between teens and non-teens in race, marital status, or timing of first prenatal visit or interview. Rate of intent to breastfeed and planned duration and exclusivity of breastfeeding, as well as most measured attitudes about breastfeeding including "back to work" plans, were not significantly different between groups. Significant determinants of feeding intent included primiparity, good self-assessed knowledge about breastfeeding, and having support from the father of the baby. In a population at high risk for choosing not to breastfeed, we found no significant explanatory effect of age on breastfeeding intention, implying that an inclusive targeted breastfeeding intervention program may be effective for both teens and non-teens in a low-income inner-city population. We also found that the support of the father of the baby significantly influenced breastfeeding intent among our participants, suggesting that paternal involvement will be integral to the success of

Insight into the Pacific Sea Surface Temperature- North American Hydroclimate Connection from an Eastern Tropical North Pacific Coral Record

Science.gov (United States)

Sanchez, S. C.; Charles, C. D.; Carriquiry, J. D.

2015-12-01

The last few years of record-breaking climate anomalies across North America--a resilient atmospheric ridge and extreme drought over the West Coast, and severe winters across the Midwest and East Coast regions--have been linked to anomalous Pacific sea surface temperatures (Seager et al. 2014, Wang et al. 2014, Hartmann 2015). The synoptic associations prompt important questions on the relation between these unusual phenomena and extreme expressions of known Pacific decadal modes, such as the North Pacific Gyre Oscillation (NPGO). These questions motivate our pursuit to document multiple realizations of decadal variability in the Pacific-North American region through periods of varied radiative forcing. Here we introduce a 178 year, seasonally resolved Porites coral record from Clarion Island (18N, 115W), the westernmost island of the Revillagigedo Archipelago, a region both highly influenced by NPGO SST and SSS variability and critical for NPGO tropical-extratropical communication via the Seasonal Footprinting Mechanism (Vimont et al. 2003). When coupled with tree ring records from the western United States (Griffin and Anchukaitis 2014, MacDonald and Case 2005) and coral records from the central tropical Pacific (Cobb et al. 2001), the δ18O signal from the Clarion coral offers an extended framework of coherent continental hydroclimate and oceanic variability across the Pacific basin beyond the instrumental record. Over the last 200 years, we find clear commonality in the timing, magnitude and spatial expression of variability (illustrated through the NADA Atlas, Cook et al. 2004) amongst the proxy records. The strong relationship between Northeastern Pacific Clarion and the Central Pacific Palmyra record with the North American hydroclimate records can be viewed within the mechanistic framework of the NPGO; this framework is then explored over the last millennium across intervals of varied radiative forcing.

Experimental Investigation of the Effect of Particle Shape on Frictional Pressure drop in Particulate Debris Bed

Energy Technology Data Exchange (ETDEWEB)

Park, Jin Ho; Kim, Eun Ho; Park, Hyun Sun [POSTECH, Pohang (Korea, Republic of)

2014-10-15

To ensure the long-term cooling of corium in the reactor cavity, it is important to ensure the coolant ingression into the internally heat generated corium debris bed which is governed by pressure drop in porous media. For this reason, it is necessary to understand pressure drop mechanisms in porous bed to verify the feasibility of water penetration into particulate debris bed. According to the previous investigations on molten fuel-coolant interaction (FCI) experiments, it was found that quenched particulate debris bed was composed of irregular shape particles. Therefore, empirical or semiempirical models based on the Ergun equation (Ergun, 1952) for single-phase flow in porous media composed of single sized spherical particle were developed to consider the effect of particle shape on frictional pressure drop by means of adding a shape factor or modifying the Ergun constants etc. (Leva, 1959, Handley and Heggs, 1968, Macdonald, 1979, Foumeny et al., 1996). An experimental investigate on single-phase frictional pressure drop of water in packed bed was conducted in the transparent cylindrical test section with the inner diameter of 100 mm and the height of 700 mm to study the effect of particle shape on frictional pressure drop in porous media. This paper reports the experimental data for spherical particles with the diameter of 2 mm and 5 mm and cylindrical particles with ED of 2 mm and 5 mm. And also, the experimental data compared with the models to predict frictional pressure drop in particulate bed. The conclusions are summarized as follows. As a result of the experiment to measure frictional pressure drop in particulate bed composed of cylindrical particles the models predict the experimental data well within 22.11 % except the Handley and Heggs model when ED is applied to the models.

Mathematical modeling of climate change and malaria transmission dynamics: a historical review.

Science.gov (United States)

Eikenberry, Steffen E; Gumel, Abba B

2018-04-24

Malaria, one of the greatest historical killers of mankind, continues to claim around half a million lives annually, with almost all deaths occurring in children under the age of five living in tropical Africa. The range of this disease is limited by climate to the warmer regions of the globe, and so anthropogenic global warming (and climate change more broadly) now threatens to alter the geographic area for potential malaria transmission, as both the Plasmodium malaria parasite and Anopheles mosquito vector have highly temperature-dependent lifecycles, while the aquatic immature Anopheles habitats are also strongly dependent upon rainfall and local hydrodynamics. A wide variety of process-based (or mechanistic) mathematical models have thus been proposed for the complex, highly nonlinear weather-driven Anopheles lifecycle and malaria transmission dynamics, but have reached somewhat disparate conclusions as to optimum temperatures for transmission, and the possible effect of increasing temperatures upon (potential) malaria distribution, with some projecting a large increase in the area at risk for malaria, but others predicting primarily a shift in the disease's geographic range. More generally, both global and local environmental changes drove the initial emergence of P. falciparum as a major human pathogen in tropical Africa some 10,000 years ago, and the disease has a long and deep history through the present. It is the goal of this paper to review major aspects of malaria biology, methods for formalizing these into mathematical forms, uncertainties and controversies in proper modeling methodology, and to provide a timeline of some major modeling efforts from the classical works of Sir Ronald Ross and George Macdonald through recent climate-focused modeling studies. Finally, we attempt to place such mathematical work within a broader historical context for the "million-murdering Death" of malaria.

Phase I trial of verubulin (MPC-6827) plus carboplatin in patients with relapsed glioblastoma multiforme.

Science.gov (United States)

Grossmann, Kenneth F; Colman, Howard; Akerley, Wallace A; Glantz, Michael; Matsuoko, Yuko; Beelen, Andrew P; Yu, Margaret; De Groot, John F; Aiken, Robert D; Olson, Jeffrey J; Olsen, Jeffery J; Evans, Brent A; Jensen, Randy L

2012-11-01

Verubulin (MPC-6827) is a microtubule-destabilizing agent that achieves high concentrations in the brain. Verubulin disrupts newly formed blood vessels in xenografts. We determined the safety and tolerability of verubulin administered in combination with carboplatin in patients with relapsed glioblastoma multiforme (GBM). Three pre-selected doses of verubulin were tested: 2.1, 2.7, and 3.3 mg/m(2) in a standard "3+3" design. Verubulin was given every second week of a 6-week cycle in the 2.1 mg/m(2) cohort or weekly for 3 weeks of a 4-week cycle in subsequent cohorts. Carboplatin was administered intravenously at an area under the curve (AUC) dosage 4 every 2 weeks for the 2.1 mg/m(2) cohort or on day 1 of each 4-week cycle in subsequent cohorts. Nineteen patients with GBM in first or second relapse were enrolled. Four patients (21 %) experienced a grade 3 or greater verubulin- or carboplatin-related adverse event, including hypesthesia, cerebral ischemia, anemia, and thrombocytopenia. The mean plasma half life of verubulin was 3.2 h (SD = 0.82). Two patients achieved at least a partial response by Macdonald criteria. One of these patients remains progression free and off treatment more than 24 months beyond his initiation of verubulin. Five patients had stable disease. Median progression-free survival (PFS) across all patients was 8 weeks, and the 6-month PFS rate was 21 %. The combination of verubulin at the previously determined single-agent maximum tolerated dose of 3.3 mg/m(2) with carboplatin in patients with recurrent/refractory GBM is safe and well tolerated. In this patient population with a highly vascularized tumor, no cerebral hemorrhage was observed.

CADrx for GBM Brain Tumors: Predicting Treatment Response from Changes in Diffusion-Weighted MRI

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Matthew S. Brown

2009-11-01

Full Text Available The goal of this study was to develop a computer-aided therapeutic response (CADrx system for early prediction of drug treatment response for glioblastoma multiforme (GBM brain tumors with diffusion weighted (DW MR images. In conventional Macdonald assessment, tumor response is assessed nine weeks or more post-treatment. However, we will investigate the ability of DW-MRI to assess response earlier, at five weeks post treatment. The apparent diffusion coefficient (ADC map, calculated from DW images, has been shown to reveal changes in the tumor’s microenvironment preceding morphologic tumor changes. ADC values in treated brain tumors could theoretically both increase due to the cell kill (and thus reduced cell density and decrease due to inhibition of edema. In this study, we investigated the effectiveness of features that quantify changes from pre- and post-treatment tumor ADC histograms to detect treatment response. There are three parts to this study: first, tumor regions were segmented on T1w contrast enhanced images by Otsu’s thresholding method, and mapped from T1w images onto ADC images by a 3D region of interest (ROI mapping tool using DICOM header information; second, ADC histograms of the tumor region were extracted from both pre- and five weeks post-treatment scans, and fitted by a two-component Gaussian mixture model (GMM. The GMM features as well as standard histogram-based features were extracted. Finally, supervised machine learning techniques were applied for classification of responders or non-responders. The approach was evaluated with a dataset of 85 patients with GBM under chemotherapy, in which 39 responded and 46 did not, based on tumor volume reduction. We compared adaBoost, random forest and support vector machine classification algorithms, using ten-fold cross validation, resulting in the best accuracy of 69.41% and the corresponding area under the curve (Az of 0.70.

Laboratory Experiments Enabling Electron Beam use in Tenuous Space Plasmas

Science.gov (United States)

Miars, G.; Leon, O.; Gilchrist, B. E.; Delzanno, G. L.; Castello, F. L.; Borovsky, J.

2017-12-01

A mission concept is under development which involves firing a spacecraft-mounted electron beam from Earth's magnetosphere to connect distant magnetic field lines in real time. To prevent excessive spacecraft charging and consequent beam return, the spacecraft must be neutralized in the tenuous plasma environment of the magnetosphere. Particle-In-Cell (PIC) simulations suggest neutralization can be accomplished by emitting a neutral plasma with the electron beam. Interpretation of these simulations also led to an ion emission model in which ion current is emitted from a quasi-neutral plasma as defined by the space charge limit [1,2]. Experiments were performed at the University of Michigan's Plasmadynamics and Electric Propulsion Laboratory (PEPL) to help validate the ion emission model. A hollow cathode plasma contactor was used as a representative spacecraft and charged with respect to the chamber walls to examine the effect of spacecraft charging on ion emission. Retarding Potential Analyzer (RPA) measurements were performed to understand ion flow velocity as this parameter relates directly to the expected space charge limit. Planar probe measurements were also made to identify where ion emission primarily occurred and to determine emission current density levels. Evidence of collisions within the plasma (particularly charge exchange collisions) and a simple model predicting emitted ion velocities are presented. While a detailed validation of the ion emission model and of the simulation tools used in [1,2] is ongoing, these measurements add to the physical understanding of ion emission as it may occur in the magnetosphere. 1. G.L. Delzanno, J.E. Borovsky, M.F. Thomsen, J.D. Moulton, and E.A. MacDonald, J. Geophys. Res. Space Physics 120, 3647, 2015. 2. G.L. Delzanno, J.E. Borovsky, M.F. Thomsen, and J.D. Moulton, J. Geophys. Res. Space Physics 120, 3588, 2015. ________________________________ * This work is supported by Los Alamos National Laboratory.

Epidemiological models for the spread of anti-malarial resistance

Directory of Open Access Journals (Sweden)

Antia R

2003-02-01

Full Text Available Abstract Background The spread of drug resistance is making malaria control increasingly difficult. Mathematical models for the transmission dynamics of drug sensitive and resistant strains can be a useful tool to help to understand the factors that influence the spread of drug resistance, and they can therefore help in the design of rational strategies for the control of drug resistance. Methods We present an epidemiological framework to investigate the spread of anti-malarial resistance. Several mathematical models, based on the familiar Macdonald-Ross model of malaria transmission, enable us to examine the processes and parameters that are critical in determining the spread of resistance. Results In our simplest model, resistance does not spread if the fraction of infected individuals treated is less than a threshold value; if drug treatment exceeds this threshold, resistance will eventually become fixed in the population. The threshold value is determined only by the rates of infection and the infectious periods of resistant and sensitive parasites in untreated and treated hosts, whereas the intensity of transmission has no influence on the threshold value. In more complex models, where hosts can be infected by multiple parasite strains or where treatment varies spatially, resistance is generally not fixed, but rather some level of sensitivity is often maintained in the population. Conclusions The models developed in this paper are a first step in understanding the epidemiology of anti-malarial resistance and evaluating strategies to reduce the spread of resistance. However, specific recommendations for the management of resistance need to wait until we have more data on the critical parameters underlying the spread of resistance: drug use, spatial variability of treatment and parasite migration among areas, and perhaps most importantly, cost of resistance.

Evaluation of early imaging response criteria in glioblastoma multiforme

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Gladwish, Adam; Koh, Eng-Siew; Hoisak, Jeremy; Lockwood, Gina; Millar, Barbara-Ann; Mason, Warren; Yu, Eugene; Laperriere, Normand J; Ménard, Cynthia

2011-01-01

Early and accurate prediction of response to cancer treatment through imaging criteria is particularly important in rapidly progressive malignancies such as Glioblastoma Multiforme (GBM). We sought to assess the predictive value of structural imaging response criteria one month after concurrent chemotherapy and radiotherapy (RT) in patients with GBM. Thirty patients were enrolled from 2005 to 2007 (median follow-up 22 months). Tumor volumes were delineated at the boundary of abnormal contrast enhancement on T1-weighted images prior to and 1 month after RT. Clinical Progression [CP] occurred when clinical and/or radiological events led to a change in chemotherapy management. Early Radiologic Progression [ERP] was defined as the qualitative interpretation of radiological progression one month post-RT. Patients with ERP were determined pseudoprogressors if clinically stable for ≥6 months. Receiver-operator characteristics were calculated for RECIST and MacDonald criteria, along with alternative thresholds against 1 year CP-free survival and 2 year overall survival (OS). 13 patients (52%) were found to have ERP, of whom 5 (38.5%) were pseudoprogressors. Patients with ERP had a lower median OS (11.2 mo) than those without (not reached) (p < 0.001). True progressors fared worse than pseudoprogressors (median survival 7.2 mo vs. 19.0 mo, p < 0.001). Volume thresholds performed slightly better compared to area and diameter thresholds in ROC analysis. Responses of > 25% in volume or > 15% in area were most predictive of OS. We show that while a subjective interpretation of early radiological progression from baseline is generally associated with poor outcome, true progressors cannot be distinguished from pseudoprogressors. In contrast, the magnitude of early imaging volumetric response may be a predictive and quantitative metric of favorable outcome

Determination of the rate constant for the OH(X2Π) + OH(X2Π) → H2O + O(3P) reaction over the temperature range 295 to 701 K.

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Altinay, Gokhan; Macdonald, R Glen

2014-01-09

The rate constant for the radical-radical reaction OH(X(2)Π) + OH(X(2)Π) → H2O + O((3)P) has been measured over the temperature and pressure ranges 295-701 K and 2-12 Torr, respectively, in mixtures of CF4, N2O, and H2O. The OH radical was produced by the 193 nm laser photolysis of N2O. The resulting O((1)D) atoms reacted rapidly with H2O to produce the OH radical. The OH radical was detected by high-resolution time-resolved infrared absorption spectroscopy using a single Λ-doublet component of the OH(1,0) P1e/f(4.5) fundamental vibrational transition. A detailed kinetic model was used to determine the reaction rate constant as a function of temperature. These experiments were conducted in a new temperature controlled reaction chamber. The values of the measured rate constants are quite similar to the previous measurements from this laboratory of Bahng and Macdonald (J. Phys. Chem. A 2007 , 111 , 3850 - 3861); however, they cover a much larger temperature range. The results of the present work do not agree with recent measurements of Sangwan and Krasnoperov (J. Phys. Chem. A 2012 , 116 , 11817 - 11822). At 295 K the rate constant of the title reaction was found to be (2.52 ± 0.63) × 10(-12) cm(3) molecule(-1) s(-1), where the uncertainty includes both experimental scatter and an estimate of systematic errors at the 95% confidence limit. Over the temperature range of the experiments, the rate constant can be represented by k1a = 4.79 × 10(-18)T(1.79) exp(879.0/T) cm(3) molecule(-1) s(-1) with a uncertainty of ±24% at the 2σ level, including experimental scatter and systematic error.

What's next? Where do we go from here?

International Nuclear Information System (INIS)

Fox, J.; Rounding, M.; Roman, A.

1997-01-01

A panel consisting of John Fox, Vice President of Ontario Hydro, Marie Rounding , Chairperson of the Ontario Energy Board and Andrew Roman, partner in the Toronto law firm of Miller Thomson, had the task to sum up for the conference and to reflect upon the state of the electricity industry and its future prospects at home and abroad. John Fox emphasized the interconnectedness of the industry in North America, Ontario Hydro's firm commitment to unfettered access of all sellers to all buyers, the proliferating experiments with retail access throughout North America, and the need for a neutral, independent and functioning marketplace entity operating at arm's length from any generating facility. He iterated Ontario Hydro's conviction that breaking up Hydro Generation would not serve the best interest of the province, and that should it be undertaken in spite of Ontario Hydro's advice, it would not be too long before it would coalesce under new ownership, probably offshore ownership. Marie Rounding stressed that while market transitions already underway in other jurisdictions will force Ontario to act on the Macdonald Report, the government will need some time to examine an extremely complex decision that will have major impact on the province, therefore it should not be rushed unduly. She also emphasized the need for regulation, Hydro's most recent restructuring proposals notwithstanding. Andrew Roman agreed with the OBE Chairperson about the need for regulation during the transition to open markets, and expressed the opinion that Ontario Hydro's recent actions suggest that despite Hydro's protests to the contrary, 'it wants more not less of the status quo'. He suggested that the urgent problem is to convince the government not to buy into Ontario Hydro's vision of a single dominant generator in Ontario, and to create, without much delay, the legislation and regulations necessary to open up competition, and then decide where the Corporation goes from here

The IGF1 small dog haplotype is derived from Middle Eastern grey wolves

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Ostrander Elaine A

2010-02-01

Full Text Available Abstract Background A selective sweep containing the insulin-like growth factor 1 (IGF1 gene is associated with size variation in domestic dogs. Intron 2 of IGF1 contains a SINE element and single nucleotide polymorphism (SNP found in all small dog breeds that is almost entirely absent from large breeds. In this study, we surveyed a large sample of grey wolf populations to better understand the ancestral pattern of variation at IGF1 with a particular focus on the distribution of the small dog haplotype and its relationship to the origin of the dog. Results We present DNA sequence data that confirms the absence of the derived small SNP allele in the intron 2 region of IGF1 in a large sample of grey wolves and further establishes the absence of a small dog associated SINE element in all wild canids and most large dog breeds. Grey wolf haplotypes from the Middle East have higher nucleotide diversity suggesting an origin there. Additionally, PCA and phylogenetic analyses suggests a closer kinship of the small domestic dog IGF1 haplotype with those from Middle Eastern grey wolves. Conclusions The absence of both the SINE element and SNP allele in grey wolves suggests that the mutation for small body size post-dates the domestication of dogs. However, because all small dogs possess these diagnostic mutations, the mutations likely arose early in the history of domestic dogs. Our results show that the small dog haplotype is closely related to those in Middle Eastern wolves and is consistent with an ancient origin of the small dog haplotype there. Thus, in concordance with past archeological studies, our molecular analysis is consistent with the early evolution of small size in dogs from the Middle East. See associated opinion by Driscoll and Macdonald: http://jbiol.com/content/9/2/10

Chemotherapy for intracranial ependymoma in adults

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Gramatzki, Dorothee; Roth, Patrick; Felsberg, Jörg; Hofer, Silvia; Rushing, Elisabeth J.; Hentschel, Bettina; Westphal, Manfred; Krex, Dietmar; Simon, Matthias; Schnell, Oliver; Wick, Wolfgang; Reifenberger, Guido; Weller, Michael

2016-01-01

Ependymal tumors in adults are rare, accounting for less than 4 % of primary tumors of the central nervous system in this age group. The low prevalence of intracranial ependymoma in adults limits the ability to perform clinical trials. Therefore, treatment decisions are based on small, mostly retrospective studies and the role of chemotherapy has remained unclear. We performed a retrospective study on 17 adult patients diagnosed with intracranial World Health Organisation grade II or III ependymoma, who were treated with chemotherapy at any time during the disease course. Benefit from chemotherapy was estimated by applying Macdonald criteria. Progression-free (PFS) and overall survival (OS) were calculated from start of chemotherapy, using the Kaplan-Meier method. Eleven patients had supratentorial and 6 infratentorial tumors. Ten patients were treated with temozolomide (TMZ), 3 with procarbazine/lomustine/vincristine (PCV), 3 with platinum-based chemotherapy and 1 patient received epirubicin/ifosfamide. Response rates were as follows: TMZ 8/10 stable disease; PCV 3/3 stable disease; platinum-based chemotherapy 1/3 partial response; epirubicin/ifosfamide 1/1 complete response. PFS rates at 6, 12 and 24 months were 52.9, 35.3 and 23.5 %. OS rates at 6, 12 and 24 months were 82.4, 82.4 and 70.1 %. There was no indication for a favourable prognostic role of O 6 -methylguanyl-DNA-methyltransferase (MGMT) promoter methylation which was detected in 3/12 investigated tumors. Survival outcomes in response to chemotherapy in adult intracranial ependymoma patients vary substantially, but individual patients may respond to any kind of chemotherapy. There were too few patients to compare survival data between chemotherapeutic subgroups. The online version of this article (doi:10.1186/s12885-016-2323-0) contains supplementary material, which is available to authorized users

The inelastic scattering of 2Pi [case (b)] molecules and an understanding of the differing Λ doublet propensities for molecules of π vs π3 orbital occupancy

International Nuclear Information System (INIS)

Dagdigian, P.J.; Alexander, M.H.; Liu, K.; Department of Chemistry, University of Maryland, College Park, Maryland 20742; Gas Phase Chemical Dynamics Group, Chemistry Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439)

1989-01-01

The quantum formalism for the scattering of a diatomic molecule in a 2 Pi electronic state which is well described by Hund's case (b) limit is investigated here. For a particular JF/sub i/ yields J'F'/sub 1/ transition, quantum interference effects will lead to preferential population of one of the final state Λ doublet levels. The nonstatistical population of final state Λ doublet levels arises from an interference between terms in the expansion of the two electrostatic potential energy surfaces, of A' and A'' reflection symmetry, which describe the interaction between a molecule in a Pi electronic state and a closed-shell partner. The particular Λ doublet level preferred is opposite for molecules of π 1 vs π 3 electron occupancy. The physical origin of this reversal in the Λ doublet propensity is a direct reflection of the fact that for the former the A' potential surface is more repulsive since the sole π electron lies in the triatomic plane in this case, whereas for molecules of π 3 electron occupancy the A' surface is less repulsive than the A'' surface since for the A' surface only one of the three π electrons lies in the triatomic plane. The magnitude of these Λ doublet propensities is illustrated by calculated cross sections for the CH(X 2 Pi)--He system using the ab initio potential energy surfaces calculated by the Argonne theoretical group, and these cross sections are compared to those of the crossed molecular study of Liu and Macdonald [J. Chem. Phys. 61, xxxx (1989)]. A similar analysis is carried out for collisions of a molecule of π 3 electron occupancy and is illustrated by inelastic collisions of OH(X 2 Pi)

Relationships between problematic alcohol consumption and delinquent behaviour from adolescence to young adulthood.

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Miller, Peter G; Butler, Erin; Richardson, Ben; Staiger, Petra K; Youssef, George J; Macdonald, Jacqui A; Sanson, Ann; Edwards, Ben; Olsson, Craig A

2016-05-01

Heavy episodic drinking (HED) has been associated with increased risk for short- and long-term injury and harms, such as violence and delinquent behaviour; however, the temporal relationship between the two remains unclear, particularly on transition to young adulthood. This study investigates transactional pathways between HED and delinquent behaviour from adolescence to emerging adulthood. Data were drawn from the Australian Temperament Project; a population-based longitudinal study that has followed the health and development of participants (and parents) across 30 years from birth in 1982. The analytic sample was 1650 participants and included five measurement waves spanning adolescence (3 waves: 13-18 years) and young adulthood (2 waves; 19-24 years). There was strong continuity across waves of both HED and delinquency, as well as across-time associations between them. Delinquent behaviour in adolescence was associated with up to twofold increases in the odds of HED at each subsequent adolescent wave. HED in the late teens was associated with over fourfold increases in the odds of persistent (two waves) HED in young adulthood. HED in the late teens was associated with increases in the odds of delinquent behaviour in young adulthood (over twofold for male and one and a half-fold for female participants). While delinquent behaviour predicts both future HED and future delinquent behaviour in adolescence, once young people reach the legal drinking age of 18 years, HED becomes a predictor of current and future delinquent behaviour and future HED, suggesting that increased access to alcohol increases the likelihood of young people engaging in delinquent behaviour. [Miller PG, Butler E, Richardson B, Staiger PK, Youssef GJ, Macdonald JA, Sanson A, Edwards B, Olsson CA. Relationships between problematic alcohol consumption and delinquent behaviour from adolescence to young adulthood. Drug Alcohol Rev 2016;35:317-325]. © 2015 Australasian Professional Society on

A common neural substrate for language production and verbal working memory.

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Acheson, Daniel J; Hamidi, Massihullah; Binder, Jeffrey R; Postle, Bradley R

2011-06-01

Verbal working memory (VWM), the ability to maintain and manipulate representations of speech sounds over short periods, is held by some influential models to be independent from the systems responsible for language production and comprehension [e.g., Baddeley, A. D. Working memory, thought, and action. New York, NY: Oxford University Press, 2007]. We explore the alternative hypothesis that maintenance in VWM is subserved by temporary activation of the language production system [Acheson, D. J., & MacDonald, M. C. Verbal working memory and language production: Common approaches to the serial ordering of verbal information. Psychological Bulletin, 135, 50-68, 2009b]. Specifically, we hypothesized that for stimuli lacking a semantic representation (e.g., nonwords such as mun), maintenance in VWM can be achieved by cycling information back and forth between the stages of phonological encoding and articulatory planning. First, fMRI was used to identify regions associated with two different stages of language production planning: the posterior superior temporal gyrus (pSTG) for phonological encoding (critical for VWM of nonwords) and the middle temporal gyrus (MTG) for lexical-semantic retrieval (not critical for VWM of nonwords). Next, in the same subjects, these regions were targeted with repetitive transcranial magnetic stimulation (rTMS) during language production and VWM task performance. Results showed that rTMS to the pSTG, but not the MTG, increased error rates on paced reading (a language production task) and on delayed serial recall of nonwords (a test of VWM). Performance on a lexical-semantic retrieval task (picture naming), in contrast, was significantly sensitive to rTMS of the MTG. Because rTMS was guided by language production-related activity, these results provide the first causal evidence that maintenance in VWM directly depends on the long-term representations and processes used in speech production.

MEDEX 2015: Heart Rate Variability Predicts Development of Acute Mountain Sickness.

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Sutherland, Angus; Freer, Joseph; Evans, Laura; Dolci, Alberto; Crotti, Matteo; Macdonald, Jamie Hugo

2017-09-01

Sutherland, Angus, Joseph Freer, Laura Evans, Alberto Dolci, Matteo Crotti, and Jamie Hugo Macdonald. MEDEX 2015: Heart rate variability predicts development of acute mountain sickness. High Alt Med Biol. 18: 199-208, 2017. Acute mountain sickness (AMS) develops when the body fails to acclimatize to atmospheric changes at altitude. Preascent prediction of susceptibility to AMS would be a useful tool to prevent subsequent harm. Changes to peripheral oxygen saturation (SpO 2 ) on hypoxic exposure have previously been shown to be of poor predictive value. Heart rate variability (HRV) has shown promise in the early prediction of AMS, but its use pre-expedition has not previously been investigated. We aimed to determine whether pre- and intraexpedition HRV assessment could predict susceptibility to AMS at high altitude with better diagnostic accuracy than SpO 2 . Forty-four healthy volunteers undertook an expedition in the Nepali Himalaya to >5000 m. SpO 2 and HRV parameters were recorded at rest in normoxia and in a normobaric hypoxic chamber before the expedition. On the expedition HRV parameters and SpO 2 were collected again at 3841 m. A daily Lake Louise Score was obtained to assess AMS symptomology. Low frequency/high frequency (LF/HF) ratio in normoxia (cutpoint ≤2.28 a.u.) and LF following 15 minutes of exposure to normobaric hypoxia had moderate (area under the curve ≥0.8) diagnostic accuracy. LF/HF ratio in normoxia had the highest sensitivity (85%) and specificity (88%) for predicting AMS on subsequent ascent to altitude. In contrast, pre-expedition SpO 2 measurements had poor (area under the curve <0.7) diagnostic accuracy and inferior sensitivity and specificity. Pre-ascent measurement of HRV in normoxia was found to be of better diagnostic accuracy for AMS prediction than all measures of HRV in hypoxia, and better than peripheral oxygen saturation monitoring.

Art for the Apocalypse: Sculpture by Frink in Losey’s The Damned

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Susan Felleman

2014-07-01

Full Text Available Blacklisted and exiled, American director Joseph Losey finished The Damned in England in 1961 but Hammer Films did not release it until 1963 (then with severe cuts and it wasn’t seen until 1965 in the U.S., further changed and retitled These Are the Damned. Adapted by Evan Jones from The Children of Light, a novel by H.L. Lawrence, The Damned is a strange hybrid of science fiction, horror and social commentary that in some ways anticipates by a decade Kubrick’s A Clockwork Orange. Beautifully photographed in black-and-white on location in Weymouth, it brings a mysterious American stranger (Macdonald Carey—perhaps a fugitive—into a violent confrontation with a gang of Teddy Boys and ultimately into a deadly, dystopic government experiment with radioactive children. Among the film’s considerable changes to Lawrence’s narrative was the addition of a major character: a sculptor, whose cliff-top studio is a vivid and key location and whose works function as visual omens of a social and technological apocalypse to come. Freya Neilson (Viveca Lindfors was conceived expressly to employ the work of sculptor Elisabeth Frink (1930-1993, whose scarred, distressed figural works of the period included anthropomorphic birds, winged men, fallen men, horse heads and other morbid ciphers of existential dread. In the film these works of plaster and bronze embody the age of anxiety even as they represent art as a redemptive alternative to the cold-bloodedness of both lowbrow Teddy Boy (Oliver Reed and highbrow Government scientist (Alexander Knox. Associated with the postwar structure of feeling that Herbert Read characterized as “the geometry of fear,” Frink’s work performs a major role in The Damned, giving form to psychosocial ills and fears of the postwar generation. 

Origins of food reinforcement in infants12345

Science.gov (United States)

Kong, Kai Ling; Feda, Denise M; Eiden, Rina D; Epstein, Leonard H

2015-01-01

Background: Rapid weight gain in infancy is associated with a higher risk of obesity in children and adults. A high relative reinforcing value of food is cross-sectionally related to obesity; lean children find nonfood alternatives more reinforcing than do overweight/obese children. However, to our knowledge, there is no research on how and when food reinforcement develops. Objective: This study was designed to assess whether the reinforcing value of food and nonfood alternatives could be tested in 9- to 18-mo-old infants and whether the reinforcing value of food and nonfood alternatives is differentially related to infant weight status. Design: Reinforcing values were assessed by using absolute progressive ratio schedules of reinforcement, with presentation of food and nonfood alternatives counterbalanced in 2 separate studies. Two nonfood reinforcers [Baby Einstein–Baby MacDonald shows (study 1, n = 27) or bubbles (study 2, n = 30)] were tested against the baby’s favorite food. Food reinforcing ratio (FRR) was quantified by measuring the reinforcing value of food (Food Pmax) in proportion to the total reinforcing value of food and a nonfood alternative (DVD Pmax or BUB Pmax). Results: Greater weight-for-length z score was associated with a greater FRR of a favorite food in study 1 (FRR-DVD) (r = 0.60, P positively associated with FRR-DVD (r = 0.57, P = 0.009) and FRR-BUB (r = 0.37, P = 0.047). Conclusions: Our newly developed paradigm, which tested 2 different nonfood alternatives, demonstrated that lean infants find nonfood alternatives more reinforcing than do overweight/obese infants. This observation suggests that strengthening the alternative reinforcers may have a protective effect against childhood obesity. This research was registered at clinicaltrials.gov as NCT02229552. PMID:25733636

In situ Rumen Degradation Kinetics of High-Protein Forage Crops in Temperate Climates Cinética de Degradación Ruminal in situ en Forrajes de Alto Contenido Proteico en Clima Templado

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Ximena Valderrama L.

2011-12-01

Full Text Available The present study was conducted to evaluate the nutritional value and in situ degradation kinetics of eight high protein forage crops: alfalfa (Medicago sativa L., forage oat (Avena sativa L., mixed pasture, and ryegrass (Lolium multiflorum Lam. pasture in early vegetative stages, two forage lupins (Lupinus albus L. in early bloom stages, sugar beet (Beta vulgaris L. and kale (Brassica napus var. pabularia (DC. Rchb. leaves at root maturity. Dry matter (DM and crude protein (CP degradation kinetics were evaluated by the nylon bag technique through the in situ procedure described by 0rskov and MacDonald (1979 using three ruminally cannulated sheep. Chemical composition of the forage crops showed on average 13.7% DM; 21.4% CP; 31.5% neutral detergent fiber (NDF; 17.7% crude fiber (CF, 80.6% digestibility of organic matter (DOMD and 12.13 MJ kg-1 metabolizable energy (ME. The high total degradability of forage crops reported here (> 87% DM; > 93% CP can be associated with the presence of large quantities of fraction a (> 34% DMa; > 29% CPa and high degradability of fraction b, resulting in low amounts of undegradable fraction (U (7.02% DM and 3.55% CP. Correlations between CPb and DMb degradability (r = 0.79 and CPc and DMc degradation rates (r = 0.78 were high, however differences in c were not explained by differences in CP or NDF contents, nor by the amounts of a or b fractions. Degradation for DM and CP during the first 6 h of incubation was strongly and inversely correlated to b (36 h (r = 0.93 (P El presente estudio se desarrolló con el objetivo de evaluar el valor nutricional y la cinética de degradación in situ de ocho forrajes de alto valor proteico: alfalfa (Medicago sativa L., avena (Avena sativa L., pastos mixtos y pastos de ballica (Lolium multiflorum Lam., en las primeras etapas vegetativas, dos lupinos forrajeros (Lupinus albus L. en etapas inicio de la floración, hojas de remolacha azucarera (Beta vulgaris L. y de col (Brassica

What has happened in about the last 20 years in the Canyoles watershed?

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Ángel González Peñaloza, Félix; Cerdà, Artemi; Díaz del Olmo, Fernando

2013-04-01

Along history, the Mediterranean arid lands have undergone widespread land use transformation, especially in recent decades (Piqueras, 2012). There are changes driven by socio-economic conditions, such as European Agricultural Policies (MacDonald et al., 2000; Keenleyside and Tucker, 2010; Renwick et al., 2013), which have caused land degradation processes (soil erosion, soil sealing, water pollution, salinization, wildfires, land abandonment, urban sprawl and intensive agricultural practices). Land degradation is the results of a complex Socio Ecological System (SES) which should be addressed using the Geographical Information System (GIS) to identify and assess the spatial variation of land use change. Therefore, the aim of this work has been to describe and assess the land use change by human activities in a typical Mediterranean watershed (Cànyoles Valley) located at South-East of Iberian Peninsula as a part of the Land Ecosystem and Degradation Desertification Response Assessment (LEDDRA) project, which has undergone a quick land use change in last two decades (1986 - 2005). Results reveal that the surface area devoted to rainfed crops (e.g., olive crops (47 %) and vineyards (28 %) and forestry have decline significantly; while the citrus orchards (irrigated crops) and unproductive areas (e.g., roads and railways, urban areas) have been increasing its surface in just about last 20 years in 45 % and 67 %, respectively. According to the literature review (Cerdà, 1994; Cerdá et al., 1999, 2007; Cerdà, 2007; Bodí et al., 2012; González-Peñaloza, 2012) these recent changes, in the study site, have caused many environmental disturbances mainly due to the lack control strategies plans of land degradation. Acknowledgements This research is being conducted by the EU project "Land Ecosystem and Degradation Desertification: Assessing the Fit of Responses" LEDDRA 243857 CONSORTIUM AGREEMENT. TR07 - VII PROGRAMA MARCO - ENERGÍA FP7-ENERGY-2007-2-TREN. - European

Disability Surveillance in multiple sclerosis patients before and after methylprednisolone treatment

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Ghabaae M

2007-10-01

Full Text Available Background: Multiple sclerosis (MS is a chronic inflammatory disease of the central nervous system resulting from demyelination and axonal loss. Although treatment of MS has progressed, patients continue to have attacks and treatment for such episodes remains a subject of ongoing study. The object of this study is to determine the effect of intravenous methylprednisolone (IVMP on the degree of disability in MS patients."nMethods: This cross-sectional study involved 63 patients with a definite diagnosis of MS, based on the MacDonald criteria, at the Iranian Center for Neurological Research at Imam Khomeini Hospital, Tehran, Iran, from March 2004 through March 2005. After obtaining informed consent, investigators gathered data including each patient's age, gender, pyramidal activity status, cortical, cerebellar and brain stem activity status, sensory signals in the extremities, including vibration, touch, pain, position, visual status, as well as bladder and intestinal activity, and Expanded Disability Status Scale (EDSS score. SPSS version 11 was used for data analysis."nResults: A five-day regimen of IVMP (5g significantly reduced the immediate post-treatment score from 4.595 to 3.635, which represents a 96% improvement in the EDSS. The greatest change in functional system disability was seen in the pyramidal system with a mean score of 1.13. After treatment, the rate of disability reduction in the sensory system, cerebellum, vision, bladder and intestinal activity was 0.57, 0.49, 0.46, 0.4, and 0.38, respectively. Patients who had experienced fewer relapses responded better to treatment. There was no statistically significant relationship between patient age and the level of response to treatment. However, the rate of disability reduction after treatment was greater in males than females (p=0.05."nConclusion: These results show that IVMP treatment induces an immediate post-treatment effect that could partly account for clinical and

TH-A-BRF-09: Integration of High-Resolution MRSI Into Glioblastoma Treatment Planning

Energy Technology Data Exchange (ETDEWEB)

Schreibmann, E; Cordova, J; Shu, H; Crocker, I; Curran, W; Holder, C; Shim, H [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA (United States)

2014-06-15

Purpose: Identification of a metabolite signature that shows significant tumor cell infiltration into normal brain in regions that do not appear abnormal on standard MRI scans would be extremely useful for radiation oncologists to choose optimal regions of brain to treat, and to quantify response beyond the MacDonald criteria. We report on integration of high-resolution magnetic resonance spectroscopic imaging (HR-MRSI) with radiation dose escalation treatment planning to define and target regions at high risk for recurrence. Methods: We propose to supplement standard MRI with a special technique performed on an MRI scanner to measure the metabolite levels within defined volumes. Metabolite imaging was acquired using an advanced MRSI technique combining 3D echo-planar spectroscopic imaging (EPSI) with parallel acquisition (GRAPPA) using a multichannel head coil that allows acquisition of whole brain metabolite maps with 108 μl resolution in 12 minutes implemented on a 3T MR scanner. Elevation in the ratio of two metabolites, choline (Cho, elevated in proliferating high-grade gliomas) and N-acetyl aspartate (NAA, a normal neuronal metabolite), was used to image infiltrating high-grade glioma cells in vivo. Results: The metabolite images were co-registered with standard contrast-enhanced T1-weighted MR images using in-house registration software and imported into the treatment-planning system. Regions with tumor infiltration are identified on the metabolic images and used to create adaptive IMRT plans that deliver a standard dose of 60 Gy to the standard target volume and an escalated dose of 75 Gy (or higher) to the most suspicious regions, identified as areas with elevated Cho/NAA ratio. Conclusion: We have implemented a state-of-the-art HR-MRSI technology that can generate metabolite maps of the entire brain in a clinically acceptable scan time, coupled with introduction of an imaging co-registration/ analysis program that combines MRSI data with standard imaging

Chevkinite-group minerals from granulite-facies metamorphic rocks and associated pegmatites of East Antarctica and South India

Science.gov (United States)

Belkin, Harvey E.; Macdonald, R.; Grew, E.S.

2009-01-01

Electron microprobe data are presented for chevkinite-group minerals from granulite-facies rocks and associated pegmatites of the Napier Complex and Mawson Station charnockite in East Antarctica and from the Eastern Ghats, South India. Their compositions conform to the general formula for this group, viz. A4BC2D2Si4O22 where, in the analysed specimens A = (rare-earth elements (REE), Ca, Y, Th), B = Fe2+, Mg, C = (Al, Mg, Ti, Fe2+, Fe3+, Zr) and D = Ti and plot within the perrierite field of the total Fe (as FeO) (wt.%) vs. CaO (wt.%) discriminator diagram of Macdonald and Belkin (2002). In contrast to most chevkinite-group minerals, the A site shows unusual enrichment in the MREE and HREE relative to the LREE and Ca. In one sample from the Napier Complex, Y is the dominant cation among the total REE + Y in the A site, the first reported case of Y-dominance in the chevkinite group. The minerals include the most Al-rich yet reported in the chevkinite group (≤9.15 wt.% Al2O3), sufficient to fill the C site in two samples. Conversely, the amount of Ti in these samples does not fill the D site, and, thus, some of the Al could be making up the deficiency at D, a situation not previously reported in the chevkinite group. Fe abundances are low, requiring Mg to occupy up to 45% of the B site. The chevkinite-group minerals analysed originated from three distinct parageneses: (1) pegmatites containing hornblende and orthopyroxene or garnet; (2) orthopyroxene-bearing gneiss and granulite; (3) highly aluminous paragneisses in which the associated minerals are relatively magnesian or aluminous. Chevkinite-group minerals from the first two parageneses have relatively high FeO content and low MgO and Al2O3 contents; their compositions plot in the field for mafic and intermediate igneous rocks. In contrast, chevkinite-group minerals from the third paragenesis are notably more aluminous and have greater Mg/Fe ratios

8th International Conference on Physics and its Applications (ICOPIA)

International Nuclear Information System (INIS)

2016-01-01

Proceeding of 8 th International Conference of Physics and Its Applications (8 th ICOPIA) 2016 Preface International Conference of Physics and Its Applications (ICOPIA) is a biannual conference, started in 2001, for presenting and discussing current research in Physics and Its Applications. This year of 2016, this conference is the eighth one. Studies about material physics, optics, geophysics, instrumentation, magnetics and theoretical physics are presented either orally or by poster. This conference is mainly supported by Department of Physics, University of Sebelas Maret, Indonesia. The keynote presentations are provided especially to show the contribution of physicists to medical research. A study of pT resolution magnetic sensor utilizing MI element towards medical use is presented by Prof. Tsuyoshi Uchiyama, from Nagoya University, Japan. Presentation about computational intelligence technique for electroencephalography (EEG) analysis is delivered by Assoc. Prof. Lipo Wang from Nanyang Technological University, Singapore. Keynote presentation about polycapillary optic and its application in medical imaging which is provided by Prof. Carolyn Ann Macdonald, from University At Albany, USA. Understanding the synergic and competitive interaction between Polyvinyl alcohol and plasticizers onto Na-Bentonite Clay is presented by Khairuddin, Ph.D, from University of Sebelas Maret, Indonesia. This volume contains the papers presented in ICOPIA 2016. The papers are divided into eight sections: magnetism and magnetic material, material physics and characterization, acoustics, theoretical physics, instrumentation physics, optics and geophysics. This structure is made so that readers are easier to find an article in this proceeding. We would like to thank to all of the participants attending this conference and also to committee for their contribution to this high level conference and its overall success. We also would like to thank to the reviewers for their positive

A multicharge ion source (Supernanogan) for the OLIS facility at ISAC/TRIUMF.

Science.gov (United States)

Jayamanna, K; Wight, G; Gallop, D; Dube, R; Jovicic, V; Laforge, C; Marchetto, M; Leross, M; Louie, D; Laplante, R; Laxdal, R; McDonald, M; Wiebe, G J; Wang, V; Yan, F

2010-02-01

The Off-Line Ion Source (OLIS) [K. Jayamanna, D. Yuan, T. Kuo, M. MacDonald, P. Schmor, and G. Dutto, Rev. Sci. Instrum. 67, 1061 (1996); K. Jayamanna, Rev. Sci. Instrum. 79, 02711 (2008)] facility consists of a high voltage terminal containing a microwave cusp ion source, either a surface ion source or a hybrid surface-arc discharge ion source [K. Jayamanna and C. Vockenhuber, Rev. Sci. Instrum. 79, 02C712 (2008)], and an electrostatic switch that allows the selection of any one of the sources without mechanical intervention. These sources provide a variety of +1 beams up to mass 30 for Isotope Separator and ACcelerator (ISAC) [R. E. Laxdal, Nucl. Instrum. Methods Phys. Res. B 204, 400 (2003)] experiments, commissioning the accelerators, setting up the radioactive experiments, and for tuning the beam lines. The radio frequency quadrupole (RFQ) [M. Marchetto, Z. T. Ang, K. Jayamanna, R. E. Laxdal, A. Mitra, and V. Zvyagintsev, Eur. Phys. J. Spec. Top. 150, 241 (2005)] injector accelerator is a constant velocity machine designed to accept only 2 keV/u and the source extraction energy is limited to 60 kV. Further stripping is then needed downstream of the RFQ to inject the beam into the drift tube linac [M. Marchetto, Z. T. Ang, K. Jayamanna, R. E. Laxdal, A. Mitra, and V. Zvyagintsev, Eur. Phys. J. Spec. Top. 150, 241 (2005)] accelerator that requires A/q up to 6. Base on this constraints a multicharge ion source capable to deliver beams above mass 30 with A/q up to 6 was needed in order to reach full capability of the ISAC facility. A Supernanogan [C. Bieth et al., Nucleonika 48, S93 (2003)] multicharge ion source was then purchased from Pantechnik and was installed in the OLIS terminal. Commissioning and performance of the Supernanogan with some results such as emittance dependence of the charge states as well as charge state efficiencies are presented.

3D-MR Spectroscopic Imaging at 3Tesla for Early Response Assessment of Glioblastoma Patients during External Beam Radiation Therapy

Science.gov (United States)

Muruganandham, Manickam; Clerkin, Patrick P; Smith, Brian J; Anderson, Carryn M; Morris, Ann; Capizzano, Aristides A; Magnotta, Vincent; McGuire, Sarah M; Smith, Mark C; Bayouth, John E; Buatti, John M

2014-01-01

Purpose To evaluate the utility of 3D-MR proton spectroscopic imaging for treatment planning and its implications for early response assessment in glioblastoma multiforme. Methods and Materials Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium enhanced MR images at simulation and at boost treatment planning after 17-20 fractions of radiotherapy. All patients received standard radiotherapy with temozolomide and follow-up with every two month MR scans. Progression free survival was defined using MacDonald criteria. MRSI images obtained at initial simulation were analyzed for choline / N-acetylaspartate ratios (Cho/NAA) on a voxel by voxel basis with abnormal activity defined as Cho/NAA ≥ 2. These images were compared on anatomically matched MRSI data collected after 3 weeks of radiotherapy. Changes in Cho/NAA between pre-therapy and 3rd week RT scans were tested using Wilcoxon matched-pairs signed rank tests and correlated with progression free survival, radiation dose and location of recurrence using Cox proportional hazards regression. Results After 8.6 months (median follow-up), 50% of patients had progressed based on imaging. Patients with a decreased or stable mean or median Cho/NAA values had less risk of progression (p< 0.01). Patients with an increase in mean or median Cho/NAA values at the 3rd week RT scan had a significantly greater chance of early progression (p <0.01). An increased Cho/NAA at the 3rd week MRSI scan carried a hazard ratio of 2.72 (95% confidence interval 1.10-6.71, p= 0.03). Most patients received the prescription dose of RT to the Cho/NAA ≥ 2 volume, which was where recurrence most often occurred. Conclusion Change in mean and median Cho/NAA detected at 3 weeks was a significant predictor of early progression. The potential impact for risk-adaptive therapy based on early spectroscopic findings is suggested. PMID:24986746

3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy.

Science.gov (United States)

Muruganandham, Manickam; Clerkin, Patrick P; Smith, Brian J; Anderson, Carryn M; Morris, Ann; Capizzano, Aristides A; Magnotta, Vincent; McGuire, Sarah M; Smith, Mark C; Bayouth, John E; Buatti, John M

2014-09-01

To evaluate the utility of 3-dimensional magnetic resonance (3D-MR) proton spectroscopic imaging for treatment planning and its implications for early response assessment in glioblastoma multiforme. Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy. All patients received standard radiation therapy (RT) with concurrent temozolomide followed by adjuvant temozolomide. Imaging for response assessment consisted of MR scans every 2 months. Progression-free survival was defined by the criteria of MacDonald et al. MRSI images obtained at initial simulation were analyzed for choline/N-acetylaspartate ratios (Cho/NAA) on a voxel-by-voxel basis with abnormal activity defined as Cho/NAA ≥2. These images were compared on anatomically matched MRSI data collected after 3 weeks of RT. Changes in Cho/NAA between pretherapy and third-week RT scans were tested using Wilcoxon matched-pairs signed rank tests and correlated with progression-free survival, radiation dose and location of recurrence using Cox proportional hazards regression. After a median follow-up time of 8.6 months, 50% of patients had experienced progression based on imaging. Patients with a decreased or stable mean or median Cho/NAA values had less risk of progression (P<.01). Patients with an increase in mean or median Cho/NAA values at the third-week RT scan had a significantly greater chance of early progression (P<.01). An increased Cho/NAA at the third-week MRSI scan carried a hazard ratio of 2.72 (95% confidence interval, 1.10-6.71; P=.03). Most patients received the prescription dose of RT to the Cho/NAA ≥2 volume, where recurrence most often occurred. Change in mean and median Cho/NAA detected at 3 weeks was a significant predictor of early progression. The potential impact for risk

Editor's welcome, PORTAL, Vol. 4, No. 1, January 2007

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Paul Allatson

2007-01-01

Full Text Available PORTAL Journal of Multidisciplinary International Studies enters its fourth year with the journal’s first special Chinese-language issue. Organised under the rubric of ‘The Revival of Chinese Cultural Nationalism,’ the issue has been guest edited by Dr Yingjie Guo of the Institute for International Studies, University of Technology Sydney, and features the work of scholars based in China and Australia. As Guo says in his introductory essay to the special issue, debates over cultural nationalism in China have been on the rise since the events in Tiananmen Square on June 4, 1989; indeed, the post-Tiananmen era in China may be witnessing what Guo calls an unparalleled cultural-political movement in the country’s history. The various contributors to this special issue explore the ramifications and manifestations of that broad cultural-political movement in film production, television drama, literary texts, cultural essays, regional entrepreneurship, and contemporary debates on nationalism and liberalism. This issue of PORTAL also features four non-special issue essays: a study of feminist ethics in the work of Filipino-Australian writer and dramatist Merlinda Bobis, by Dolores Herrero (Universidad de Zaragoza, Spain; a taut critique of the discourse that regards the twentieth century as the bloodiest and most atrocious in human history, by David B. MacDonald (Otago University, New Zealand; a trenchant analysis, by Ramzi Nasser and Kamal Abouchedid (Notre Dame University, Lebanon, of what the authors call the rise of “academic apartheid” in the university sector throughout the Arab world; and a fascinating exploration of the feminism and environmentalism pioneered by the Australian author, mountaineer, solicitor and Buddhist Marie Byles (1900-1979, by Allison Cadzow (University of Technology Sydney. Finally, it is a huge pleasure to also include in PORTAL’s cultural works section a selection of poems by the Chinese poet Yang Lian

TH-A-BRF-09: Integration of High-Resolution MRSI Into Glioblastoma Treatment Planning

International Nuclear Information System (INIS)

Schreibmann, E; Cordova, J; Shu, H; Crocker, I; Curran, W; Holder, C; Shim, H

2014-01-01

Purpose: Identification of a metabolite signature that shows significant tumor cell infiltration into normal brain in regions that do not appear abnormal on standard MRI scans would be extremely useful for radiation oncologists to choose optimal regions of brain to treat, and to quantify response beyond the MacDonald criteria. We report on integration of high-resolution magnetic resonance spectroscopic imaging (HR-MRSI) with radiation dose escalation treatment planning to define and target regions at high risk for recurrence. Methods: We propose to supplement standard MRI with a special technique performed on an MRI scanner to measure the metabolite levels within defined volumes. Metabolite imaging was acquired using an advanced MRSI technique combining 3D echo-planar spectroscopic imaging (EPSI) with parallel acquisition (GRAPPA) using a multichannel head coil that allows acquisition of whole brain metabolite maps with 108 μl resolution in 12 minutes implemented on a 3T MR scanner. Elevation in the ratio of two metabolites, choline (Cho, elevated in proliferating high-grade gliomas) and N-acetyl aspartate (NAA, a normal neuronal metabolite), was used to image infiltrating high-grade glioma cells in vivo. Results: The metabolite images were co-registered with standard contrast-enhanced T1-weighted MR images using in-house registration software and imported into the treatment-planning system. Regions with tumor infiltration are identified on the metabolic images and used to create adaptive IMRT plans that deliver a standard dose of 60 Gy to the standard target volume and an escalated dose of 75 Gy (or higher) to the most suspicious regions, identified as areas with elevated Cho/NAA ratio. Conclusion: We have implemented a state-of-the-art HR-MRSI technology that can generate metabolite maps of the entire brain in a clinically acceptable scan time, coupled with introduction of an imaging co-registration/ analysis program that combines MRSI data with standard imaging

Shakespeare revived in contemporary canadian drama Shakespeare à l’honneur dans le théâtre canadien contemporain

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Rüdiger Ahrens

2009-10-01

Full Text Available L’une des preuves de l’universalité « de tous les temps » (Ben Jonson de Shakespeare est que ses pièces ont aussi été adaptées dans presque tous les pays de ce monde, que ce soit sous leur forme quasi-historique ou au cours d’un échange intertextuel libre de versions hybrides. L’émergence d’une conscience post-coloniale dans de nombreux points du monde a produit une ré-interprétation critique de ses œuvres dans le sens d’une réévaluation émancipatrice qui transforme les prétextes shakespeariens de façon le plus souvent créatrice en tentant d’attirer l’attention du public. La variété des interprétations possibles peut être illustrée par le cas du Canada, qui n’est pas tant un pays post-colonial mais plutôt un pays de colons, au moyen de trois exemples de pièces contemporaines : Ken Mitchell, Cruel Tears (1977, Anne-Marie MacDonald, Goodnight Desdemona (Good Night Juliet (1990, et Ken Grass, Claudius (1993. Ces pièces illustrent la variété de l’influence shakespearienne sur la scène canadienne qui peut se vanter d’autres pièces remarquables comme Fortune and Men’s Eyes de John Herbert (1967, qui reprend le sujet des relations hommes-femmes avec ses références aux Sonnets et à The Taming of the Shrew, la comédie de John Murrel Gertrude and Ophelia (1987, qui est fondée sur les répercussions psychologiques et sociales du féminisme et du racisme, comme c’est le cas dans Harlem Duet de Jane Sears (1997. Toutes ces adaptations rendent compte aussi des innombrables possibilités de références intertextuelles fournies par les pièces originales de Shakespeare.

MEDEX2015: Greater Sea-Level Fitness Is Associated with Lower Sense of Effort During Himalayan Trekking Without Worse Acute Mountain Sickness.

Science.gov (United States)

Rossetti, Gabriella M K; Macdonald, Jamie H; Smith, Matthew; Jackson, Anna R; Callender, Nigel; Newcombe, Hannah K; Storey, Heather M; Willis, Sebastian; van den Beukel, Jojanneke; Woodward, Jonathan; Pollard, James; Wood, Benjamin; Newton, Victoria; Virian, Jana; Haswell, Owen; Oliver, Samuel J

2017-06-01

Rossetti, Gabriella M.K., Jamie H. Macdonald, Matthew Smith, Anna R. Jackson, Nigel Callender, Hannah K. Newcombe, Heather M. Storey, Sebastian Willis, Jojanneke van den Beukel, Jonathan Woodward, James Pollard, Benjamin Wood, Victoria Newton, Jana Virian, Owen Haswell, and Samuel J. Oliver. MEDEX2015: Greater sea-level fitness is associated with lower sense of effort during Himalayan trekking without worse acute mountain sickness. High Alt Med Biol. 18:152-162, 2017.-This study examined the complex relationships of fitness and hypoxic sensitivity with submaximal exercise responses and acute mountain sickness (AMS) at altitude. Determining these relationships is necessary before fitness or hypoxic sensitivity tests can be recommended to appraise individuals' readiness for altitude. Forty-four trekkers (26 men; 18 women; 20-67 years) completed a loaded walking test and a fitness questionnaire in normoxia to measure and estimate sea-level maximal aerobic capacity (maximum oxygen consumption [[Formula: see text]O 2max ]), respectively. Participants also completed a hypoxic exercise test to determine hypoxic sensitivity (cardiac, ventilatory, and arterial oxygen saturation responses to acute hypoxia, fraction of inspired oxygen [Fio 2 ] = 0.112). One month later, all participants completed a 3-week trek to 5085 m with the same ascent profile. On ascent to 5085 m, ratings of perceived exertion (RPE ascent ), fatigue by Brunel Mood Scale, and AMS were recorded daily. At 5085 m, RPE during a fixed workload step test (RPE fixed ) and step rate during perceptually regulated exercise (STEP RPE35 ) were recorded. Greater sea-level [Formula: see text]O 2max was associated with, and predicted, lower sense of effort (RPE ascent ; r = -0.43; p sea-level fitness reported less effort during simulated and actual trekking activities, had better mood (less fatigue), and chose a higher step rate during perceptually regulated exercise, but did not suffer from worse AMS

Dietary intervention in the management of phenylketonuria: current perspectives

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Rocha JC

2016-12-01

Full Text Available Júlio César Rocha,1-3 Anita MacDonald4 1Centro de Genética Médica, Centro Hospitalar do Porto – CHP, 2Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, 3Center for Health Technology and Services Research (CINTESIS, Porto, Portugal; 4The Children’s Hospital, Birmingham, UK Abstract: Phenylketonuria (PKU is a well-described inborn error of amino acid metabolism that has been treated for >60 years. Enzyme deficiency causes accumulation of phenylalanine (Phe and if left untreated will lead to profound and irreversible intellectual disability in most children. Traditionally, it has been managed with a low-Phe diet supplemented with a Phe-free protein substitute although newer treatment options mainly in combination with diet are available for some subgroups of patients with PKU, for example, sapropterin, large neutral amino acids, and glycomacropeptide. The diet consists of three parts: 1 severe restriction of dietary Phe; 2 replacement of non-Phe L-amino acids with a protein substitute commonly supplemented with essential fatty acids and other micronutrients; and 3 low-protein foods from fruits, some vegetables, sugars, fats and oil, and special low-protein foods (SLPF. The prescription of diet is challenging for health professionals. The high-carbohydrate diet supplied by a limited range of foods may program food preferences and contribute to obesity in later life. Abnormal tasting and satiety-promoting protein substitutes are administered to coincide with peak appetite times to ensure their consumption, but this practice may impede appetite for other important foods. Intermittent dosing of micronutrients when combined with L-amino acid supplements may lead to their poor bioavailability. Much work is required on the ideal nutritional profiling for special SLPF and Phe-free L-amino acid supplements. Although non-diet treatments are being studied, it is important to continue to fully understand all the consequences of diet

Fission product release from defected nuclear reactor fuel elements

International Nuclear Information System (INIS)

Lewis, B.J.

1983-01-01

The release of gaseous (krypton and xenon) and iodine radioactive fission products from defective fuel elements is described with a semi-empirical model. The model assumes precursor-corrected 'Booth diffusional release' in the UO 2 and subsequent holdup in the fuel-to-sheath gap. Transport in the gap is separately modelled with a phenomenological rate constant (assuming release from the gap is a first order rate process), and a diffusivity constant (assuming transport in the gap is dominated by a diffusional process). Measured release data from possessing various states of defection are use in this analysis. One element (irradiated in an earlier experiment by MacDonald) was defected with a small drilled hole. A second element was machined with 23 slits while a third element (fabricated with a porous end plug) displayed through-wall sheath hydriding. Comparison of measured release data with calculated values from the model yields estimates of empirical diffusion coefficients for the radioactive species in the UO 2 (1.56 x 10 -10 to 7.30 x 10 -9 s -1 ), as well as escape rate constants (7.85 x 10 -7 to 3.44 x 10 -5 s -1 ) and diffusion coefficients (3.39 x 10 -5 to 4.88 x 10 -2 cm 2 /s) for these in the fuel-to-sheath gap. Analyses also enable identification of the various rate-controlling processes operative in each element. For the noble gas and iodine species, the rate-determining process in the multi-slit element is 'Booth diffusion'; however, for the hydrided element an additional delay results from diffusional transport in the fuel-to-heath gap. Furthermore, the iodine species exhibit an additional holdup in the drilled element because of significant trapping on the fuel and/or sheath surfaces. Using experimental release data and applying the theoretical results of this work, a systematic procedure is proposed to characterize fuel failures in commercial power reactors (i.e., the number of fuel failures and average leak size)

Preliminary materials selection issues for the next generation nuclear plant reactor pressure vessel.

Energy Technology Data Exchange (ETDEWEB)

Natesan, K.; Majumdar, S.; Shankar, P. S.; Shah, V. N.; Nuclear Engineering Division

2007-03-21

In the coming decades, the United States and the entire world will need energy supplies to meet the growing demands due to population increase and increase in consumption due to global industrialization. One of the reactor system concepts, the Very High Temperature Reactor (VHTR), with helium as the coolant, has been identified as uniquely suited for producing hydrogen without consumption of fossil fuels or the emission of greenhouse gases [Generation IV 2002]. The U.S. Department of Energy (DOE) has selected this system for the Next Generation Nuclear Plant (NGNP) Project, to demonstrate emissions-free nuclear-assisted electricity and hydrogen production within the next 15 years. The NGNP reference concepts are helium-cooled, graphite-moderated, thermal neutron spectrum reactors with a design goal outlet helium temperature of {approx}1000 C [MacDonald et al. 2004]. The reactor core could be either a prismatic graphite block type core or a pebble bed core. The use of molten salt coolant, especially for the transfer of heat to hydrogen production, is also being considered. The NGNP is expected to produce both electricity and hydrogen. The process heat for hydrogen production will be transferred to the hydrogen plant through an intermediate heat exchanger (IHX). The basic technology for the NGNP has been established in the former high temperature gas reactor (HTGR) and demonstration plants (DRAGON, Peach Bottom, AVR, Fort St. Vrain, and THTR). In addition, the technologies for the NGNP are being advanced in the Gas Turbine-Modular Helium Reactor (GT-MHR) project, and the South African state utility ESKOM-sponsored project to develop the Pebble Bed Modular Reactor (PBMR). Furthermore, the Japanese HTTR and Chinese HTR-10 test reactors are demonstrating the feasibility of some of the planned components and materials. The proposed high operating temperatures in the VHTR place significant constraints on the choice of material selected for the reactor pressure vessel for

Validation Studies for Numerical Simulations of Flow Phenomena Expected in the Lower Plenum of a Prismatic VHTR Reference Design

International Nuclear Information System (INIS)

Richard W. Johnson

2005-01-01

The final design of the very high temperature reactor (VHTR) of the fourth generation of nuclear power plants (Gen IV) has not yet been established. The VHTR may be either a prismatic (block) or pebble bed type. It may be either gas-cooled or cooled with an as yet unspecified molten salt. However, a conceptual design of a gas-cooled VHTR, based on the General Atomics GT-MHR, does exist and is called the prismatic VHTR reference design, MacDonald et al [2003], General Atomics [1996]. The present validation studies are based on the prismatic VHTR reference design. In the prismatic VHTR reference design, the flow in the lower plenum will be introduced by dozens of turbulent jets issuing into a large crossflow that must negotiate dozens of cylindrical support columns as it flows toward the exit duct of the reactor vessel. The jets will not all be at the same temperature due to the radial variation of power density expected in the core. However, it is important that the coolant be well mixed when it enters the power conversion unit to ensure proper operation and long life of the power conversion machinery. Hence, it is deemed important to be able to accurately model the flow and mixing of the variable temperature coolant in the lower plenum and exit duct. Accurate flow modeling involves determining modeling strategies including the fineness of the grid needed, iterative convergence tolerance, numerical discretization method used, whether the flow is steady or unsteady, and the turbulence model and wall treatment employed. It also involves validation of the computer code and turbulence model against a series of separate and combined flow phenomena and selection of the data used for the validation. The present report describes progress made to date for the task entitled ''CFD software validation of jets in crossflow'' which was designed to investigate the issues pertaining to the validation process

Molecular analysis of polimorphisms in HLA-CLASS II DRB1* and IL7Rα possibly associated with multiple sclerosis susceptibility in a population sample of Rio de Janeiro

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André Luis dos Santos Figueiredo

2014-06-01

Full Text Available Multiple sclerosis (MS is an inflammatory and degenerative disease of the central nervous system (CNS that affects mainly young adults. MS seems to be a polygenic and multifactorial disease, and genetic susceptibility has been associated mainly with the major histocompatibility complex (MHC, which in humans is the human leukocyte antigen (HLA. Among non-HLA genes is the alpha chain of interleukin 7 receptor gene (IL7Rα at the 5p12-14 locus, also known as CD127. The aim of this study was to evaluate the correlations between polymorphism in the IL7Rα (rs6897932C gene, HLA-class II DRB1* haplotypes and susceptibility to multiple sclerosis in patients with Recurrent Remitting form (RRMS. METHOD: In this study, peripheral blood samples were taken from 50 patients diagnosed using the diagnostic criteria for MS according to Polman (MacDonald et al (2011. The patients were monitored at the Clinic of Neurology, Hospital Universitário Clementino Fraga Filho, along with 100 healthy control subjects matched for ancestry, sex and age. After DNA extraction by organic method, polymorphism +244 *C (rs6897932 was assessed by PCR followed by capillary electrophoresis on the ABI PRISM® 3500 Genetic Analyzer (Applied Biosystems, USA platform. RESULTS: The results indicated a significant association between the CC haplotype and RRMS (p=0.02 , OR=2.14, as well as an association between the *C allele (CC and CT and RRMS (p=0.042, OR=2.15. The same C allele was more frequent in the sample, both in patients (0.82, and in the control group (0.71. The sample, control group and patients included, was in Hardy- Weinberg equilibrium. The correlation between the presence of the CC genotype and HLA-DRB1* 15:01 was significant (OR=3.6, p=0.034. CONCLUSION: These results reinforce the polygenic/multifactorial characteristic or genetic heterogeneity of MS, indicating a relationship between putative polymorphism +244*C (CC genotype in the IL7Rα gene and susceptibility to MS

A percepção auditiva e visual das fricativas do Português Brasileiro diante da manipulação do sinal acústico

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Audinéia Ferreira-Silva

2017-06-01

Full Text Available Neste artigo, nosso objetivo é avaliar o papel das informações auditiva e visual na percepção das fricativas do Português Brasileiro, quando apresentadas com ambiguidade/manipulação do sinal acústico.  Para tanto, montamos um corpus de palavras dissílabas, com estrutura silábica C1V1.C2V2, onde C1 é uma das fricativas, C2 é a oclusiva surda e V1 eV2 são uma das vogais/a/, /i/ ou /u/. Após a gravação do corpus, o sinal acústico das fricativas foi manipulado em termos de duração do ruído e frequência do espectro. Nossos resultados evidenciam que os índices de identificação das fricativas foram, de maneira geral, maiores quando elas apresentavam a informação audiovisual. Nossos achados atestam que, quando as fricativas têm seu sinal manipulado, em termos de duração e frequência, seu desempenho perceptual aumenta nos casos em que a informação visual é apresentada com a auditiva, ou seja, diante da manipulação do sinal, as fricativas apresentam médias de recuperação mais altas com a informação audiovisual do que com a informação, apenas, auditiva. Esses resultados corroboram os tradicionais estudos de Sumby e Pollack (1954 e McGurk e MacDonald (1976, que afirmam que, na percepção, os ouvintes integram visão e audição. Assim, e considerando os pressupostos do FLMP de Massaro (1987, nossos resultados evidenciam que, na percepção da fala, cada fonte de informação é mais influenciável, na medida em que a outra fonte é mais ambígua.

Clinical features and multidisciplinary approaches to dementia care

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Gr

2011-05-01

Full Text Available Jacob HG Grand¹, Sienna Caspar², Stuart WS MacDonald11Department of Psychology, University of Victoria, Victoria, BC, Canada; 2Interdisciplinary Graduate Studies, University of British Columbia, Vancouver, BC, CanadaAbstract: Dementia is a clinical syndrome of widespread progressive deterioration of cognitive abilities and normal daily functioning. These cognitive and behavioral impairments pose considerable challenges to individuals with dementia, along with their family members and caregivers. Four primary dementia classifications have been defined according to clinical and research criteria: 1 Alzheimer’s disease; 2 vascular dementias; 3 frontotemporal dementias; and 4 dementia with Lewy bodies/Parkinson’s disease dementia. The cumulative efforts of multidisciplinary healthcare teams have advanced our understanding of dementia beyond basic descriptions, towards a more complete elucidation of risk factors, clinical symptoms, and neuropathological correlates. The characterization of disease subtypes has facilitated targeted management strategies, advanced treatments, and symptomatic care for individuals affected by dementia. This review briefly summarizes the current state of knowledge and directions of dementia research and clinical practice. We provide a description of the risk factors, clinical presentation, and differential diagnosis of dementia. A summary of multidisciplinary team approaches to dementia care is outlined, including management strategies for the treatment of cognitive impairments, functional deficits, and behavioral and psychological symptoms of dementia. The needs of individuals with dementia are extensive, often requiring care beyond traditional bounds of medical practice, including pharmacologic and non-pharmacologic management interventions. Finally, advanced research on the early prodromal phase of dementia is reviewed, with a focus on change-point models, trajectories of cognitive change, and threshold models of

Coupling of Large Eddy Simulations with Meteorological Models to simulate Methane Leaks from Natural Gas Storage Facilities

Science.gov (United States)

Prasad, K.

2017-12-01

Atmospheric transport is usually performed with weather models, e.g., the Weather Research and Forecasting (WRF) model that employs a parameterized turbulence model and does not resolve the fine scale dynamics generated by the flow around buildings and features comprising a large city. The NIST Fire Dynamics Simulator (FDS) is a computational fluid dynamics model that utilizes large eddy simulation methods to model flow around buildings at length scales much smaller than is practical with models like WRF. FDS has the potential to evaluate the impact of complex topography on near-field dispersion and mixing that is difficult to simulate with a mesoscale atmospheric model. A methodology has been developed to couple the FDS model with WRF mesoscale transport models. The coupling is based on nudging the FDS flow field towards that computed by WRF, and is currently limited to one way coupling performed in an off-line mode. This approach allows the FDS model to operate as a sub-grid scale model with in a WRF simulation. To test and validate the coupled FDS - WRF model, the methane leak from the Aliso Canyon underground storage facility was simulated. Large eddy simulations were performed over the complex topography of various natural gas storage facilities including Aliso Canyon, Honor Rancho and MacDonald Island at 10 m horizontal and vertical resolution. The goal of these simulations included improving and validating transport models as well as testing leak hypotheses. Forward simulation results were compared with aircraft and tower based in-situ measurements as well as methane plumes observed using the NASA Airborne Visible InfraRed Imaging Spectrometer (AVIRIS) and the next generation instrument AVIRIS-NG. Comparison of simulation results with measurement data demonstrate the capability of the coupled FDS-WRF models to accurately simulate the transport and dispersion of methane plumes over urban domains. Simulated integrated methane enhancements will be presented and

Experiences and perspectives on the GIST patient journey

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Macdonald N

2012-03-01

Full Text Available Nancy Macdonald1, Ari Shapiro1, Christina Bender2, Marc Paolantonio2, John Coombs21Flince Research + Design, New York, NY, 2Novartis Pharmaceuticals, East Hanover, NJ, USAPurpose: The tyrosine kinase inhibitor (TKI imatinib has improved outcomes for patients with unresectable or metastatic gastrointestinal stromal tumors (GIST, and for patients receiving adjuvant therapy following GIST resection. This qualitative study explored the experiences and emotions of patients through GIST diagnosis, treatment initiation, disease control, and in some patients, loss of response and therapy switch.Patients and methods: Ethnographic investigations were conducted, including semi-structured qualitative interviews of patients with resected or metastatic/unresectable GIST and their caregivers, from Canada (n = 15; the United States (n = 10; and Brazil, France, Germany, Russia, and Spain (n = 5 each. Some interviewees also kept 7-day photo journals. Responses were qualitatively analyzed to identify gaps and unmet needs where communication about disease, treatments, and adherence could be effective.Results: Patients shared common experiences during each stage of disease management (crisis, hope, adaptation, new normal, and uncertainty. Patients felt a sense of crisis during diagnosis, followed by hope upon TKI therapy initiation. Over time, they came to adapt to their new lives (new normal with cancer. With each follow-up, patients confronted the uncertainty of becoming TKI resistant and the possible need to switch therapy. During uncertainty many patients sought new information regarding GIST. Cases of disease progression and drug switching caused patients to revert to crisis and restart their emotional journey. Patients with primary or unresectable/metastatic GIST shared similar journeys, especially regarding uncertainty, although differences in the scope and timing of phases were observed. Strategies patients used to remain adherent included obtaining family

French Polynesia Hotspot Swells Explained By Dynamic Topography

Science.gov (United States)

Adam, C.; Yoshida, M.; Isse, T.; Suetsugu, D.; Shiobara, H.; Sugioka, H.; Kanazawa, T.; Fukao, Y.; Barruol, G.

2007-12-01

Situated on the South Pacific Superswell, French Polynesia is a region characterized by numerous geophysical anomalies among which a high volcanism concentration. Seven hotspots are required to explain the observed chains, volcanism ages and geochemical trends. Many open questions still remain on the origin of these hotspot chains: are they created by passive uplift of magma due to discontinuities in the structure of the lithosphere or by the ascent of mantle plumes? In this case, at which depth do these plumes initiate in the mantle? Many geophysical observations (bathymetry, gravity, magnetism, volcanism ages..) are used to understand the unique phenomenon occurring on this region. The most useful information may come from tomography models since they provide a 3D view of the mantle. Until recently, the tomography models over the region were quite inaccurate because of the sparse location of the seismic stations. The deployment of two new seismic stations networks (BBOBS and temporary island stations) has lately remedied this failing. The resulting tomography model obtained through the inversion of Rayleigh waves provides the most accurate view of the shallowest part of the mantle (depths ≤ 240 km) beneath French Polynesia. Indeed, for the first time the accuracy of a tomography model is good enough to provide information about plume phenomenology in this complex region. In order to quantify the plumes effect on the seafloor, we compute the dynamic topography through an instantaneous flow model. The general trend of the observed depths anomalies (highs and lows) is well recovered. For example the amplitude, location and extension of the swells associated with the Society, Macdonald and Rarotonga are accurately described by the dynamic model. We also find that dynamic uplift is associated with the Tuamotu archipelago which means that a part of the observed swell is due to the present day action of plumes. Since no volcanism ages are available over this chain

The crust and upper mantle of central East Greenland - implications for continental accretion and rift evolution

Science.gov (United States)

Schiffer, Christian; Balling, Niels; Ebbing, Jörg; Holm Jacobsen, Bo; Bom Nielsen, Søren

2016-04-01

.B., 2015. The East Greenland Caledonides - teleseismic signature, gravity and isostasy. Geophysical Journal International, 203, 1400-1418. 2) Schiffer, C., Stephenson, R.A., Petersen, K.D., Nielsen, S.B., Jacobsen, B.H., Balling, N. and Macdonald, D.I.M., 2015. A sub-crustal piercing point for North Atlantic reconstructions and tectonic implications. Geology, 43, 1087-1090.

Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing

Science.gov (United States)

Tellez, Helio Fernandez; Morrison, Shawnda A.; Neyt, Xavier; Mairesse, Olivier; Piacentini, Maria Francesca; Macdonald-Nethercott, Eoin; Pangerc, Andrej; Dolenc-Groselj, Leja; Eiken, Ola; Pattyn, Nathalie; Mekjavic, Igor B.; Meeusen, Romain

2016-01-01

Study Objectives: Exposure to hypoxia elevates chemosensitivity, which can lead to periodic breathing. Exercise impacts gas exchange, altering chemosensitivity; however, interactions between sleep, exercise and chronic hypoxic exposure have not been examined. This study investigated whether exercise exacerbates sleep-related periodic breathing in hypoxia. Methods: Two experimental phases. Short-Term Phase: a laboratory controlled, group-design study in which 16 active, healthy men (age: 25 ± 3 y, height: 1.79 ± 0.06 m, mass: 74 ± 8 kg) were confined to a normobaric hypoxic environment (FIO2 = 0.139 ± 0.003, 4,000 m) for 10 days, after random assignment to a sedentary (control, CON) or cycle-exercise group (EX). Long-Term Phase: conducted at the Concordia Antarctic Research Station (3,800 m equivalent at the Equator) where 14 men (age: 36 ± 9 y, height: 1.77 ± 0.09 m, mass: 75 ± 10 kg) lived for 12–14 months, continuously confined. Participants were stratified post hoc based on self-reported physical activity levels. We quantified apnea-hypopnea index (AHI) and physical activity variables. Results: Short-Term Phase: mean AHI scores were significantly elevated in the EX group compared to CON (Night1 = CON: 39 ± 51, EX: 91 ± 59; Night10 = CON: 32 ± 32, EX: 92 ± 48; P = 0.046). Long-Term Phase: AHI was correlated to mean exercise time (R2 = 0.4857; P = 0.008) and the coefficient of variation in night oxyhemoglobin saturation (SpO2; R2 = 0.3062; P = 0.049). Conclusions: Data indicate that exercise (physical activity) per se affects night SpO2 concentrations and AHI after a minimum of two bouts of moderate-intensity hypoxic exercise, while habitual physical activity in hypobaric hypoxic confinement affects breathing during sleep, up to 13+ months' duration Citation: Tellez HF, Morrison SA, Neyt X, Mairesse O, Piacentini MF, Macdonald-Nethercott E, Pangerc A, Dolenc-Groselj L, Eiken O, Pattyn N, Mekjavic IB, Meeusen R. Exercise during short-term and long

A light-assisted in situ embedment of silver nanoparticles to prepare functionalized fabrics

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Toh HS

2017-11-01

Full Text Available Her Shuang Toh,1 Roxanne Line Faure,2 Liyana Bte Mohd Amin,1 Crystal Yu Fang Hay,1 Saji George1,3 1Centre of Sustainable Nanotechnology, School of Chemical and Life Sciences, Nanyang Polytechnic, Singapore, Singapore; 2DUT Analyses Biologiques et Biochimiques, IUT Génie Biologique, Dijon, France; 3Department of Food Science and Agricultural Chemistry, Macdonald Campus, McGill University, Sainte-Anne-de-Bellevue, QC, Canada Abstract: This article presents a simple, one-step, in situ generation of silver nanoparticle-functionalized fabrics with antibacterial properties, circumventing the conventional, multistep, time-consuming methods. Silver nanoparticle formation was studied with a library of capping agents (branched polyethylenimine [BPEI] of molecular weight [Mw] 10,000 and 25,000, polyvinylpyrrolidone, polyethylene glycol, polyvinylalcohol and citrate mixed with silver nitrate. The mixture was then exposed to an assortment of light wavelengths (ultraviolet, infrared and simulated solar light for studying the light-assisted synthesis of nanoparticles. The formation of nanoparticles corresponded with the reducing capabilities of the polymers wherein BPEI gave the best response. Notably, the irradiation wavelengths had little effect on the formation of the nanoparticle when the total irradiation energy was kept constant. The feasibility of utilizing this method for in situ nanoparticle synthesis on textile fabrics (towel [100% cotton], gauze [100% cotton], rayon, felt [100% polyester] and microfiber [15% nylon, 85% polyester] was verified by exposing the fabrics soaked in an aqueous solution of 1% (w/v AgNO3 and 1% (w/v BPEI (Mw 25,000 to light. The formation of nanoparticles on fabrics and their retention after washing was verified using scanning electron microscopy and quantified by inductively coupled plasma optical emission spectrometry. The functional property of the fabric as an antibacterial surface was successfully demonstrated using

Geophysical reassessment of the role of ancient crustal structures on the development of western Laurentia and Selwyn Basin, Yukon and Northwest Territories, Canada.

Science.gov (United States)

Hayward, N.

2017-12-01

The structure of the western margin of the North American craton (Laurentia) in the northern Canadian Cordillera and its role in the development of the Neoproterozoic-Early Paleozoic Selwyn Basin are reassessed through 3D inversion of a new compilation of aeromagnetic data and archival Bouguer gravity data. The region's tectonic history is obscured by partial burial beneath Selwyn Basin, and a tectonic overprint that includes terrane accretion, regional plutonism, and strike-slip faults with displacements of 100s and perhaps 1000s of kilometers. Despite the implied complexity, preliminary geological and geophysical based interpretations of the structure of the western margin of Laurentia, have been adopted with few refinements in over two decades. Regionally continuous, NE-trending, crustal lineaments, including the Fort Norman line and Leith Ridge fault, were interpreted as having had long-standing influence on the craton development, its western margin, and overlapping sedimentary basin. New results reveal limited evidence for the regional continuity of the NE-trending lineaments. Instead, models suggest that the structure of the Laurentian margin is characterised by segmentation on numerous shorter structures of varied strike. The western margin of the craton and its structures are bound by a NW-trending structure that connects with the Richardson Trough to the north and may have been active during rifting of the Misty Creek embayment. This boundary also marks the easternmost limit of both granitic intrusions in Selwyn Basin, which gravity models suggest are of greater extent than reflected on geological maps, and SEDEX occurrences. An ENE-trending structure beneath northern Selwyn Basin is interpreted as marking the southern edge of a previously unidentified cratonic promontory, akin to the Liard line that marks a transfer fault that bounds the promontory of the Macdonald Platform, south of Selwyn Basin. The ENE-trending structure is traced from the Tintina

Pattern recognition model to estimate intergranular stress corrosion cracking (IGSCC) at crevices and pit sites of 304 SS in BWR environments

International Nuclear Information System (INIS)

Urquidi-Macdonald, Mirna

2004-01-01

Many publications have shown that crack growth rates (CGR) due to intergranular stress corrosion cracking (IGSCC) of metals is dependent on many parameters related to the manufacturing process of the steel and the environment to which the steel is exposed. Those parameters include, but are not restricted to, the concentration of chloride, fluoride, nitrates, and sulfates, pH, fluid velocity, electrochemical potential (ECP), electrolyte conductivity, stress and sensitization applied to the steel during its production and use. It is not well established how combinations of each of these parameters impact the CGR. Many different models and beliefs have been published, resulting in predictions that sometimes disagree with experimental observations. To some extent, the models are the closest to the nature of IGSCC, however, there is not a model that fully describes the entire range of observations, due to the difficulty of the problem. Among the models, the Fracture Environment Model, developed by Macdonald et al., is the most physico-chemical model, accounting for experimental observations in a wide range of environments or ECPs. In this work, we collected experimental data on BWR environments and designed a data mining pattern recognition model to learn from that data. The model was used to generate CGR estimations as a function of ECP on a BWR environment. The results of the predictive model were compared to the Fracture Environment Model predictions. The results from those two models are very close to the experimental observations of the area corresponding to creep and IGSCC controlled by diffusion. At more negative ECPs than the potential corresponding to creep, the pattern recognition predicts an increase of CGR with decreasing ECP, while the Fracture Environment Model predicts the opposite. The results of this comparison confirm that the pattern recognition model covers 3 phenomena: hydrogen embrittlement at very negative ECP, creep at intermediate ECP, and IGSCC

Problem-Based Learning no Ensino de Contabilidade Gerencial: Relato de uma Experiência Brasileira

Directory of Open Access Journals (Sweden)

Daiana Bragueto Martins

2015-01-01

Full Text Available A presente pesquisa teve por objetivo relatar a operacionalizaçãodo método PBL em uma disciplina Contabilidade Gerencial nocurso de Ciências Contábeis de uma Instituição de Ensino Superiorbrasileira. A técnica de pesquisa utilizada foi o estudo de casoque envolveu uma abordagem descritiva das aulas de PBL, cujopropósito foi apresentar as propriedades das aulas, a forma de agire o perfil dos discentes e dos professores. A pesquisa de campoocorreu em 2013. A coleta de dados é proveniente das entrevistasrealizadas com professores, da observação participante e da análisedocumental. A análise empírica da presente pesquisa teve poralicerce os estudos de Araújo e Arantes (2009, Dochy, Segers,Bossche e Gijbels (2003, Duch, Groh e Allen (2001, MacDonald eSavin-Baden (2004, Ribeiro (2008, Schmidt (1983, Sockalingame Schimidt (2011, entre outros. Os resultados evidenciamque a integração entre os acadêmicos e as empresas a partir dautilização dos problemas práticos e reais trazidos pelos alunos doambiente de trabalho proporciona ganhos, tais como: o discenteamplia o potencial de resolução de problemas de ordem prática eprofissional; e a empresa é beneficiada, tendo em vista que poderáreceber, futuramente, profissionais qualificados, aptos à pesquisae à proposição de solução de problemas. Os professores tambémganham, pois são expostos a um ambiente contemporâneo, queproporcionam maior atualização em termos de utilização deconceitos e teorias, devido a sua contextualização. O PBL ajuda aabarcar os estudantes da geração Y, tendo em vista que o desejo departicipação e comunicação em ambiente interativo com utilizaçãode ferramentas tecnológicas são as grandes marcas dessa geração.Constatou-se que as competências desenvolvidas na abordagem doPBL são similares àquelas exigidas do contador gerencial.

Construction of a coarse-grain quasi-classical trajectory method. II. Comparison against the direct molecular simulation method

Science.gov (United States)

Macdonald, R. L.; Grover, M. S.; Schwartzentruber, T. E.; Panesi, M.

2018-02-01

findings discussed in Paper I [R. L. Macdonald et al., J. Chem. Phys. 148, 054309 (2018)], which underlines the importance of rotational energy to the dissociation process, and demonstrates that an accurate non-equilibrium chemistry model must accurately predict the deviation of rovibrational distribution from equilibrium.

How to emit a high-power electron beam from a magnetospheric spacecraft?

Science.gov (United States)

Delzanno, G. L.; Lucco Castello, F.; Borovsky, J.; Miars, G.; Leon, O.; Gilchrist, B. E.

2017-12-01

, M. F. Thomsen, J. D. Moulton, E. A. MacDonald (2015), "Future beam experiments in the magnetosphere with plasma contactors: How do we get the charge off the spacecraft?," J. Geophys. Res. Space Physics, 120.

3-Dimensional Magnetic Resonance Spectroscopic Imaging at 3 Tesla for Early Response Assessment of Glioblastoma Patients During External Beam Radiation Therapy

International Nuclear Information System (INIS)

Muruganandham, Manickam; Clerkin, Patrick P.; Smith, Brian J.; Anderson, Carryn M.; Morris, Ann; Capizzano, Aristides A.; Magnotta, Vincent; McGuire, Sarah M.; Smith, Mark C.; Bayouth, John E.; Buatti, John M.

2014-01-01

Purpose: To evaluate the utility of 3-dimensional magnetic resonance (3D-MR) proton spectroscopic imaging for treatment planning and its implications for early response assessment in glioblastoma multiforme. Methods and Materials: Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy. All patients received standard radiation therapy (RT) with concurrent temozolomide followed by adjuvant temozolomide. Imaging for response assessment consisted of MR scans every 2 months. Progression-free survival was defined by the criteria of MacDonald et al. MRSI images obtained at initial simulation were analyzed for choline/N-acetylaspartate ratios (Cho/NAA) on a voxel-by-voxel basis with abnormal activity defined as Cho/NAA ≥2. These images were compared on anatomically matched MRSI data collected after 3 weeks of RT. Changes in Cho/NAA between pretherapy and third-week RT scans were tested using Wilcoxon matched-pairs signed rank tests and correlated with progression-free survival, radiation dose and location of recurrence using Cox proportional hazards regression. Results: After a median follow-up time of 8.6 months, 50% of patients had experienced progression based on imaging. Patients with a decreased or stable mean or median Cho/NAA values had less risk of progression (P<.01). Patients with an increase in mean or median Cho/NAA values at the third-week RT scan had a significantly greater chance of early progression (P<.01). An increased Cho/NAA at the third-week MRSI scan carried a hazard ratio of 2.72 (95% confidence interval, 1.10-6.71; P=.03). Most patients received the prescription dose of RT to the Cho/NAA ≥2 volume, where recurrence most often occurred. Conclusion: Change in mean and median Cho/NAA detected at 3 weeks was a significant predictor of

3-Dimensional Magnetic Resonance Spectroscopic Imaging at 3 Tesla for Early Response Assessment of Glioblastoma Patients During External Beam Radiation Therapy

Energy Technology Data Exchange (ETDEWEB)

Muruganandham, Manickam; Clerkin, Patrick P. [Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa (United States); Smith, Brian J. [Department of Biostatistics, University of Iowa Hospitals and Clinics, Iowa City, Iowa (United States); Anderson, Carryn M.; Morris, Ann [Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa (United States); Capizzano, Aristides A.; Magnotta, Vincent [Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa (United States); McGuire, Sarah M.; Smith, Mark C.; Bayouth, John E. [Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa (United States); Buatti, John M., E-mail: john-buatti@uiowa.edu [Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa (United States)

2014-09-01

Purpose: To evaluate the utility of 3-dimensional magnetic resonance (3D-MR) proton spectroscopic imaging for treatment planning and its implications for early response assessment in glioblastoma multiforme. Methods and Materials: Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy. All patients received standard radiation therapy (RT) with concurrent temozolomide followed by adjuvant temozolomide. Imaging for response assessment consisted of MR scans every 2 months. Progression-free survival was defined by the criteria of MacDonald et al. MRSI images obtained at initial simulation were analyzed for choline/N-acetylaspartate ratios (Cho/NAA) on a voxel-by-voxel basis with abnormal activity defined as Cho/NAA ≥2. These images were compared on anatomically matched MRSI data collected after 3 weeks of RT. Changes in Cho/NAA between pretherapy and third-week RT scans were tested using Wilcoxon matched-pairs signed rank tests and correlated with progression-free survival, radiation dose and location of recurrence using Cox proportional hazards regression. Results: After a median follow-up time of 8.6 months, 50% of patients had experienced progression based on imaging. Patients with a decreased or stable mean or median Cho/NAA values had less risk of progression (P<.01). Patients with an increase in mean or median Cho/NAA values at the third-week RT scan had a significantly greater chance of early progression (P<.01). An increased Cho/NAA at the third-week MRSI scan carried a hazard ratio of 2.72 (95% confidence interval, 1.10-6.71; P=.03). Most patients received the prescription dose of RT to the Cho/NAA ≥2 volume, where recurrence most often occurred. Conclusion: Change in mean and median Cho/NAA detected at 3 weeks was a significant predictor of

Pattern recognition model to estimate intergranular stress corrosion cracking (IGSCC) at crevices and pit sites of 304 SS in BWR environments

Energy Technology Data Exchange (ETDEWEB)

Urquidi-Macdonald, Mirna [Penn State University, 212 Earth-Engineering Science Building, University Park, PA 16801 (United States)

2004-07-01

Many publications have shown that crack growth rates (CGR) due to intergranular stress corrosion cracking (IGSCC) of metals is dependent on many parameters related to the manufacturing process of the steel and the environment to which the steel is exposed. Those parameters include, but are not restricted to, the concentration of chloride, fluoride, nitrates, and sulfates, pH, fluid velocity, electrochemical potential (ECP), electrolyte conductivity, stress and sensitization applied to the steel during its production and use. It is not well established how combinations of each of these parameters impact the CGR. Many different models and beliefs have been published, resulting in predictions that sometimes disagree with experimental observations. To some extent, the models are the closest to the nature of IGSCC, however, there is not a model that fully describes the entire range of observations, due to the difficulty of the problem. Among the models, the Fracture Environment Model, developed by Macdonald et al., is the most physico-chemical model, accounting for experimental observations in a wide range of environments or ECPs. In this work, we collected experimental data on BWR environments and designed a data mining pattern recognition model to learn from that data. The model was used to generate CGR estimations as a function of ECP on a BWR environment. The results of the predictive model were compared to the Fracture Environment Model predictions. The results from those two models are very close to the experimental observations of the area corresponding to creep and IGSCC controlled by diffusion. At more negative ECPs than the potential corresponding to creep, the pattern recognition predicts an increase of CGR with decreasing ECP, while the Fracture Environment Model predicts the opposite. The results of this comparison confirm that the pattern recognition model covers 3 phenomena: hydrogen embrittlement at very negative ECP, creep at intermediate ECP, and IGSCC

Adjuvant chemo-radiation for gastric adenocarcinoma: an institutional experience

International Nuclear Information System (INIS)

Aftimos, Philippe G; Nasr, Elie A; Nasr, Dolly I; Noun, Roger J; Nasr, Fady L; Ghosn, Marwan G; El Helou, Joelle A; Chahine, Georges Y

2010-01-01

Studies have shown that surgery alone is less than satisfactory in the management of early gastric cancer, with cure rates approaching 40%. The role of adjuvant therapy was indefinite until three large, randomized controlled trials showed the survival benefit of adjuvant therapy over surgery alone. Chemoradiation therapy has been criticized for its high toxicity. 24 patients diagnosed between September 2001 and July 2007 were treated with adjuvant chemoradiation. 18 patients had the classical MacDonald regimen of 4500 cGy of XRT and chemotherapy with 5-fluorouracil (5FU) and leucovorin, while chemotherapy consisted of 5FU/Cisplatin for 6 patients. This series consisted of non-metastatic patients, 17 females and 7 males with a median age of 62.5 years. 23 patients (96%) had a performance status of 0 or 1. The full course of radiation therapy (4500 cGy) was completed by 22 patients (91.7%). Only 7 patients (36.8%) completed the total planned courses of chemotherapy. 2 local relapses (10%), 2 regional relapses (10%) and 2 distant relapses (10%) were recorded. Time to progression has not been reached. 9 patients (37.5%) died during follow-up with a median overall survival of 75 months. Patients lost a mean of 4 Kgs during radiation therapy. We recorded 6 episodes of febrile neutropenia and the most frequent toxicity was gastro-intestinal in 17 patients (70.8%) with 9 (36%) patients suffering grade 3 or 4 toxicity and 5 patients (20%) suffering from grade 3 or 4 neutropenia. 4 (17%) patients required total parenteral nutrition for a mean duration of 20 days. 4 patients suffered septic shock (17%) and 1 patient developed a deep venous thrombosis and a pulmonary embolus. Adjuvant chemo-radiation for gastric cancer is a standard at our institution and has resulted in few relapses and an interesting median survival. Toxicity rates were serious and this remains a harsh regimen with only 36.8% of patients completing the full planned courses of chemotherapy. This is due to

Optical breakdown threshold investigation of 1064 nm laser induced air plasmas

International Nuclear Information System (INIS)

Thiyagarajan, Magesh; Thompson, Shane

2012-01-01

We present the theoretical and experimental measurements and analysis of the optical breakdown threshold for dry air by 1064 nm infrared laser radiation and the significance of the multiphoton and collisional cascade ionization process on the breakdown threshold measurements over pressures range from 10 to 2000 Torr. Theoretical estimates of the breakdown threshold laser intensities and electric fields are obtained using two distinct theories namely multiphoton and collisional cascade ionization theories. The theoretical estimates are validated by experimental measurements and analysis of laser induced breakdown processes in dry air at a wavelength of 1064 nm by focusing 450 mJ max, 6 ns, 75 MW max high-power 1064 nm IR laser radiation onto a 20 μm radius spot size that produces laser intensities up to 3 - 6 TW/cm 2 , sufficient for air ionization over the pressures of interest ranging from 10 to 2000 Torr. Analysis of the measured breakdown threshold laser intensities and electric fields are carried out in relation with classical and quantum theoretical ionization processes, operating pressures. Comparative analysis of the laser air breakdown results at 1064 nm with corresponding results of a shorter laser wavelength (193 nm) [M. Thiyagarajan and J. E. Scharer, IEEE Trans. Plasma Sci. 36, 2512 (2008)] and a longer microwave wavelength (10 8 nm) [A. D. MacDonald, Microwave Breakdown in Gases (Wiley, New York, 1966)]. A universal scaling analysis of the breakdown threshold measurements provided a direct comparison of breakdown threshold values over a wide range of frequencies ranging from microwave to ultraviolet frequencies. Comparison of 1064 nm laser induced effective field intensities for air breakdown measurements with data calculated based on the collisional cascade and multiphoton breakdown theories is used successfully to determine the scaled collisional microwave portion. The measured breakdown threshold of 1064 nm laser intensities are then scaled to

A global model of malaria climate sensitivity: comparing malaria response to historic climate data based on simulation and officially reported malaria incidence

Directory of Open Access Journals (Sweden)

Edlund Stefan

2012-09-01

Full Text Available Abstract Background The role of the Anopheles vector in malaria transmission and the effect of climate on Anopheles populations are well established. Models of the impact of climate change on the global malaria burden now have access to high-resolution climate data, but malaria surveillance data tends to be less precise, making model calibration problematic. Measurement of malaria response to fluctuations in climate variables offers a way to address these difficulties. Given the demonstrated sensitivity of malaria transmission to vector capacity, this work tests response functions to fluctuations in land surface temperature and precipitation. Methods This study of regional sensitivity of malaria incidence to year-to-year climate variations used an extended Macdonald Ross compartmental disease model (to compute malaria incidence built on top of a global Anopheles vector capacity model (based on 10 years of satellite climate data. The predicted incidence was compared with estimates from the World Health Organization and the Malaria Atlas. The models and denominator data used are freely available through the Eclipse Foundation’s Spatiotemporal Epidemiological Modeller (STEM. Results Although the absolute scale factor relating reported malaria to absolute incidence is uncertain, there is a positive correlation between predicted and reported year-to-year variation in malaria burden with an averaged root mean square (RMS error of 25% comparing normalized incidence across 86 countries. Based on this, the proposed measure of sensitivity of malaria to variations in climate variables indicates locations where malaria is most likely to increase or decrease in response to specific climate factors. Bootstrapping measures the increased uncertainty in predicting malaria sensitivity when reporting is restricted to national level and an annual basis. Results indicate a potential 20x improvement in accuracy if data were available at the level ISO 3166–2

Preclinical evaluation of the effect of the combined use of the Ethicon Securestrap® Open Absorbable Strap Fixation Device and Ethicon Physiomesh™ Open Flexible Composite Mesh Device on surgeon stress during ventral hernia repair

Directory of Open Access Journals (Sweden)

Sutton N

2017-12-01

Full Text Available Nadia Sutton,1 Melinda H MacDonald,2 John Lombard,1 Bodgan Ilie,3 Piet Hinoul,4 Douglas A Granger5,6 1Global Health Economics and Market Access, Johnson & Johnson Medical Devices, New Brunswick, NJ, USA; 2Preclinical Center of Excellence, Johnson & Johnson Medical Devices Companies, Somerville, NJ, USA; 3Biostatistics, Ethicon, Somerville, NJ, USA; 4Medical Affairs, Ethicon, Somerville, NJ, USA; 5Institute for Interdisciplinary Salivary Bioscience Research (IISBR, University of California at Irvine, Irvine, CA, USA; 6Johns Hopkins University School of Nursing, Bloomberg School of Public Health, and School of Medicine, Baltimore, MD, USA Aim: To evaluate whether performing ventral hernia repairs using the Ethicon Physiomesh™ Open Flexible Composite Mesh Device in conjunction with the Ethicon Securestrap® Open Absorbable Strap Fixation Device reduces surgical time and surgeon stress levels, compared with traditional surgical repair methods. Methods: To repair a simulated ventral incisional hernia, two surgeries were performed by eight experienced surgeons using a live porcine model. One procedure involved traditional suture methods and a flat mesh, and the other procedure involved a mechanical fixation device and a skirted flexible composite mesh. A Surgery Task Load Index questionnaire was administered before and after the procedure to establish the surgeons’ perceived stress levels, and saliva samples were collected before, during, and after the surgical procedures to assess the biologically expressed stress (cortisol and salivary alpha amylase levels. Results: For mechanical fixation using the Ethicon Physiomesh Open Flexible Composite Mesh Device in conjunction with the Ethicon Securestrap Open Absorbable Strap Fixation Device, surgeons reported a 46.2% reduction in perceived workload stress. There was also a lower physiological reactivity to the intraoperative experience and the total surgical procedure time was reduced by 60

HyFlux - Part I: Regional Modeling of Methane Flux From Near-Seafloor Gas Hydrate Deposits on Continental Margins

Science.gov (United States)

MacDonald, I. R.; Asper, V.; Garcia, O. P.; Kastner, M.; Leifer, I.; Naehr, T.; Solomon, E.; Yvon-Lewis, S.; Zimmer, B.

2008-12-01

HyFlux - Part I: Regional modeling of methane flux from near-seafloor gas hydrate deposits on continental margins MacDonald, I.R., Asper, V., Garcia, O., Kastner, M., Leifer, I., Naehr, T.H., Solomon, E., Yvon-Lewis, S., and Zimmer, B. The Dept. of Energy National Energy Technology Laboratory (DOE/NETL) has recently awarded a project entitled HyFlux: "Remote sensing and sea-truth measurements of methane flux to the atmosphere." The project will address this problem with a combined effort of satellite remote sensing and data collection at proven sites in the Gulf of Mexico where gas hydrate releases gas to the water column. Submarine gas hydrate is a large pool of greenhouse gas that may interact with the atmosphere over geologic time to affect climate cycles. In the near term, the magnitude of methane reaching the atmosphere from gas hydrate on continental margins is poorly known because 1) gas hydrate is exposed to metastable oceanic conditions in shallow, dispersed deposits that are poorly imaged by standard geophysical techniques and 2) the consumption of methane in marine sediments and in the water column is subject to uncertainty. The northern GOM is a prolific hydrocarbon province where rapid migration of oil, gases, and brines from deep subsurface petroleum reservoirs occurs through faults generated by salt tectonics. Focused expulsion of hydrocarbons is manifested at the seafloor by gas vents, gas hydrates, oil seeps, chemosynthetic biological communities, and mud volcanoes. Where hydrocarbon seeps occur in depths below the hydrate stability zone (~500m), rapid flux of gas will feed shallow deposits of gas hydrate that potentially interact with water column temperature changes; oil released from seeps forms sea-surface features that can be detected in remote-sensing images. The regional phase of the project will quantify verifiable sources of methane (and oil) the Gulf of Mexico continental margin and selected margins (e.g. Pakistan Margin, South China Sea

Adjuvant chemo-radiation for gastric adenocarcinoma: an institutional experience

Directory of Open Access Journals (Sweden)

Ghosn Marwan G

2010-06-01

Full Text Available Abstract Background Studies have shown that surgery alone is less than satisfactory in the management of early gastric cancer, with cure rates approaching 40%. The role of adjuvant therapy was indefinite until three large, randomized controlled trials showed the survival benefit of adjuvant therapy over surgery alone. Chemoradiation therapy has been criticized for its high toxicity. Methods 24 patients diagnosed between September 2001 and July 2007 were treated with adjuvant chemoradiation. 18 patients had the classical MacDonald regimen of 4500 cGy of XRT and chemotherapy with 5-fluorouracil (5FU and leucovorin, while chemotherapy consisted of 5FU/Cisplatin for 6 patients. Results This series consisted of non-metastatic patients, 17 females and 7 males with a median age of 62.5 years. 23 patients (96% had a performance status of 0 or 1. The full course of radiation therapy (4500 cGy was completed by 22 patients (91.7%. Only 7 patients (36.8% completed the total planned courses of chemotherapy. 2 local relapses (10%, 2 regional relapses (10% and 2 distant relapses (10% were recorded. Time to progression has not been reached. 9 patients (37.5% died during follow-up with a median overall survival of 75 months. Patients lost a mean of 4 Kgs during radiation therapy. We recorded 6 episodes of febrile neutropenia and the most frequent toxicity was gastro-intestinal in 17 patients (70.8% with 9 (36% patients suffering grade 3 or 4 toxicity and 5 patients (20% suffering from grade 3 or 4 neutropenia. 4 (17% patients required total parenteral nutrition for a mean duration of 20 days. 4 patients suffered septic shock (17% and 1 patient developed a deep venous thrombosis and a pulmonary embolus. Conclusions Adjuvant chemo-radiation for gastric cancer is a standard at our institution and has resulted in few relapses and an interesting median survival. Toxicity rates were serious and this remains a harsh regimen with only 36.8% of patients completing the

Flood-rich and flood-poor periods in Spain in 1942-2009

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Mediero, Luis; Santillán, David; Garrote, Luis

2016-04-01

Several studies to detect trends in flood series at either national or trans-national scales have been conducted. Mediero et al. (2015) studied flood trends by using the longest streamflow records available in Europe. They found a decreasing trend in the Atlantic, Continental and Scandinavian regions. More specifically, Mediero et al. (2014) found a general decreasing trend in flood series in Spain in the period 1959-2009. Trends in flood series are usually detected by the Mann-Kendall test applied to a given period. However, the result of the Mann-Kendall test can change in terms of the starting and ending year of the series. Flood oscillations can occur and flood-rich and flood-poor periods could condition the results, especially when they are located at the beginning or end of the series. A methodology to identify statistically significant flood-rich and flood-poor periods is developed, based on the comparison between the expected sampling variability of floods when stationarity is assumed and the observed variability of floods in a given series. The methodology is applied to the longest series of annual maximum floods, peaks over threshold and counts of annual occurrences in peaks over threshold series observed in Spain in the period 1942-2009. A flood-rich period in 1950-1970 and a flood-poor period in 1970-1990 are identified in most of the selected sites. The generalised decreasing trend in flood series found by Mediero et al. (2014) could be explained by a flood-rich period placed at the beginning of the series and a flood-poor period located at the end of the series. References: Mediero, L., Kjeldsen, T.R., Macdonald, N., Kohnova, S., Merz, B., Vorogushyn, S., Wilson, D., Alburquerque, T., Blöschl, G., Bogdanowicz, E., Castellarin, A., Hall, J., Kobold, M., Kriauciuniene, J., Lang, M., Madsen, H., Onuşluel Gül, G., Perdigão, R.A.P., Roald, L.A., Salinas, J.L., Toumazis, A.D., Veijalainen, N., Óðinn Þórarinsson. Identification of coherent flood

Increasing the frequency of hand washing by healthcare workers does not lead to commensurate reductions in staphylococcal infection in a hospital ward

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Kerr Kevin G

2008-09-01

Full Text Available Abstract Background Hand hygiene is generally considered to be the most important measure that can be applied to prevent the spread of healthcare-associated infection (HAI. Continuous emphasis on this intervention has lead to the widespread opinion that HAI rates can be greatly reduced by increased hand hygiene compliance alone. However, this assumes that the effectiveness of hand hygiene is not constrained by other factors and that improved compliance in excess of a given level, in itself, will result in a commensurate reduction in the incidence of HAI. However, several researchers have found the law of diminishing returns to apply to hand hygiene, with the greatest benefits occurring in the first 20% or so of compliance, and others have demonstrated that poor cohorting of nursing staff profoundly influences the effectiveness of hand hygiene measures. Collectively, these findings raise intriguing questions about the extent to which increasing compliance alone can further reduce rates of HAI. Methods In order to investigate these issues further, we constructed a deterministic Ross-Macdonald model and applied it to a hypothetical general medical ward. In this model the transmission of staphylococcal infection was assumed to occur after contact with the transiently colonized hands of HCWs, who, in turn, acquire contamination only by touching colonized patients. The aim of the study was to evaluate the impact of imperfect hand cleansing on the transmission of staphylococcal infection and to identify, whether there is a limit, above which further hand hygiene compliance is unlikely to be of benefit. Results The model demonstrated that if transmission is solely via the hands of HCWs, it should, under most circumstances, be possible to prevent outbreaks of staphylococcal infection from occurring at a hand cleansing frequencies Conclusion Although our study confirmed hand hygiene to be an effective control measure, it demonstrated that the law of

Using Robots at Home to Support Patients With Chronic Obstructive Pulmonary Disease: Pilot Randomized Controlled Trial.

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Broadbent, Elizabeth; Garrett, Jeff; Jepsen, Nicola; Li Ogilvie, Vickie; Ahn, Ho Seok; Robinson, Hayley; Peri, Kathryn; Kerse, Ngaire; Rouse, Paul; Pillai, Avinesh; MacDonald, Bruce

2018-02-13

especially useful for patients struggling with adherence. Australian New Zealand Clinical Trials Registry ACTRN12615000259549; http://www.anzctr.org.au (Archived by WebCite at  http://www.webcitation.org/6whIjptLS). ©Elizabeth Broadbent, Jeff Garrett, Nicola Jepsen, Vickie Li Ogilvie, Ho Seok Ahn, Hayley Robinson, Kathryn Peri, Ngaire Kerse, Paul Rouse, Avinesh Pillai, Bruce MacDonald. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.02.2018.

Detectability and acceptability of continuous pulse signals for the MemoPatch® device, an electronic skin patch intended to deliver tactile medication reminder signals

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Abraham I

2015-02-01

Full Text Available Ivo Abraham,1–3 Jan De Geest,2 Wim De Geest,2 Elke De Troy,4 Karen MacDonald3 1Center for Health Outcomes and PharmacoEconomic Research, University of Arizona, Tucson, AZ, USA; 2TheraSolve, Diepenbeek, Belgium; 3Matrix45, Tucson, AZ, USA; 4Jessa Ziekenhuis, Hasselt, Belgium Background: Unintended forgetfulness is the most common cause of medication nonadherence. MemoPatch® is an electronic skin patch intended to deliver discreet tactile medication reminder stimuli. This study aimed 1 to evaluate, within an experimental setup, the detectability and acceptability of fifteen continuous bipolar pulse signals; 2 to identify variables, if any, associated with differential perception of the candidate reminder signals; and 3 to collect safety data as reported by subjects or observed by staff. Methods: This was a laboratory experiment involving 147 healthy adult volunteers (55.1% female, 98.0% Caucasian, with age 41.8±16.0 years, body mass index [BMI] 24.7±4.4, upper body adiposity 28.5%±8.3% body fat, and skin impedance 367.6±140.8Ω and using an experimental version of the MemoPatch®. Following four training signals administered in fixed order, subjects were exposed to a set of fifteen randomly sequenced signals varying in rise and fall time, width, and current, to be rated in terms of detectability ("too weak", "appropriate", or "too strong" and acceptability. Results: Ratings of "appropriate" were virtually independent of such variables as sex, BMI, upper body adiposity, and skin impedance at the patch location. Five signals were rated as "appropriate" by ≥67% of subjects and acceptable by ≥95% of subjects, virtually independently of the indicators of interest, and were retained as candidate signals for use in next stages of development and commercialization. Nine adverse events, none serious, were observed in six subjects. Conclusion: This study yielded five effective and safe candidate signals for potential use in the Memo

Visual Perceptual Echo Reflects Learning of Regularities in Rapid Luminance Sequences.

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Chang, Acer Y-C; Schwartzman, David J; VanRullen, Rufin; Kanai, Ryota; Seth, Anil K

2017-08-30

A novel neural signature of active visual processing has recently been described in the form of the "perceptual echo", in which the cross-correlation between a sequence of randomly fluctuating luminance values and occipital electrophysiological signals exhibits a long-lasting periodic (∼100 ms cycle) reverberation of the input stimulus (VanRullen and Macdonald, 2012). As yet, however, the mechanisms underlying the perceptual echo and its function remain unknown. Reasoning that natural visual signals often contain temporally predictable, though nonperiodic features, we hypothesized that the perceptual echo may reflect a periodic process associated with regularity learning. To test this hypothesis, we presented subjects with successive repetitions of a rapid nonperiodic luminance sequence, and examined the effects on the perceptual echo, finding that echo amplitude linearly increased with the number of presentations of a given luminance sequence. These data suggest that the perceptual echo reflects a neural signature of regularity learning.Furthermore, when a set of repeated sequences was followed by a sequence with inverted luminance polarities, the echo amplitude decreased to the same level evoked by a novel stimulus sequence. Crucially, when the original stimulus sequence was re-presented, the echo amplitude returned to a level consistent with the number of presentations of this sequence, indicating that the visual system retained sequence-specific information, for many seconds, even in the presence of intervening visual input. Altogether, our results reveal a previously undiscovered regularity learning mechanism within the human visual system, reflected by the perceptual echo. SIGNIFICANCE STATEMENT How the brain encodes and learns fast-changing but nonperiodic visual input remains unknown, even though such visual input characterizes natural scenes. We investigated whether the phenomenon of "perceptual echo" might index such learning. The perceptual echo is a

And the last word ...

Science.gov (United States)

1999-07-01

Considerable coverage appeared in the national media in April following a talk by Averil Macdonald at the Institute of Physics Annual Congress in Salford. Averil, who recently received the 1999 Bragg Medal of the Institute for her contributions to physics education, notably advocated single-sex science classes for all school students over the age of 11 and flashy cars for physics teachers! This would, she hoped, go a long way towards encouraging girls to take up careers in science and engineering. It is well known that girls from single-sex schools do better at science than those in mixed schools, whereas boys perform better when both boys and girls are present. Averil wondered whether we should be prepared to sacrifice girls' potential achievements just so that boys can do better in mixed classes, as well as the latter benefiting from the `civilizing' influence of their female counterparts. Teaching styles could also be adding to the problem since boys prefer the model of an explanation followed by a test of understanding adopted by most teachers. Girls, however, benefit most from a more cooperative teaching style and also get better results with continuous assessment - so Averil wondered why we are still using a qualifications system in which most marks are given for examination performance. Science, and particularly physics, needs to be seen as a rewarding, high prestige career - hence the mention of the expensive car! In addition, girls need to be reassured that they can cope well with physics, even when it forms part of a `science' syllabus, since everyone should have their work in each science properly recognized and rewarded more fairly. Averil concluded that if some of the factors that hinder girls' success could be removed then more women might share the challenges of a science-based career and the UK's scientific and technical achievements would undoubtedly benefit. Shortly before Averil's talk, a new resource became available for girls and women seeking

Exploring older adults’ perceptions of a patient-centered education manual for hip fracture recovery: “everything in one place”

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Tsui K

2015-11-01

Full Text Available Karen Tsui,1,2,* Lena Fleig,1,3,4,* Dolores P Langford,2,5 Pierre Guy,1,2,6 Valerie MacDonald,7,8 Maureen C Ashe1,31Centre for Hip Health and Mobility, The University of British Columbia, 2Vancouver Coastal Health, 3Department of Family Practice, The University of British Columbia, Vancouver, BC, Canada; 4Health Psychology, Freie Universität Berlin, Berlin, Germany; 5Department of Physical Therapy, The University of British Columbia, 6Department of Orthopaedics, 7School of Nursing, The University of British Columbia, Vancouver, 8Fraser Health Authority, Surrey, BC, Canada*These authors contributed equally to this workPurpose: To describe older adults’ perspectives on a new patient education manual for the recovery process after hip fracture.Materials and methods: The Fracture Recovery for Seniors at Home (FReSH Start manual is an evidence-based manual for older adults with fall-related hip fracture. The manual aims to support the transition from hospital to home by facilitating self-management of the recovery process. We enrolled 31 community-dwelling older adults with previous fall-related hip fracture and one family member. We collected data using a telephone-based questionnaire with eight five-point Likert items and four semi-structured open-ended questions to explore participants’ perceptions on the structure, content, and illustration of the manual. The questionnaire also asked participants to rate the overall utility (out of 10 points and length of the manual. We used content analysis to describe main themes from responses to the open-ended interview questions.Results: Participants’ ratings for structure, content, and illustrations ranged from 4 to 5 (agree to highly agree, and the median usefulness rating was 9 (10th percentile: 7, 90th percentile: 10. Main themes from the content analysis included: ease of use and presentation; health literacy; illustration utility; health care team delivery; general impression, information

The REDIH experience: an emerging design to develop an effective training program for graduate students in reproductive science

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MacDonald CJ

2013-10-01

Full Text Available Colla J MacDonald,1 Douglas Archibald,2 Jay M Baltz,3 Gerald M Kidder4 1Faculty of Education, 2Department of Family Medicine, University of Ottawa, Ottawa, ON, Canada; 3Ottawa Hospital Research Institute, Ottawa, ON, Canada; 4Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada Background: A training program in Reproduction, Early Development, and the Impact on Health (REDIH was initiated in 2009 by researchers specializing in biomedical, clinical, population health, and ethics research from seven collaborating universities in Quebec and Ontario, and Health Canada. This paper reports the findings from the first three years of the 6-year program. Objectives: The objective of the REDIH program is to provide increased opportunities for excellent training in reproduction and early development for graduate students and fellows, in order to build research, clinical, regulatory, decision-making, and industry capacity in Canada. Methods: A mixed methods approach was used to evaluate the REDIH training program, so as to combine the strengths of both qualitative and quantitative studies. A total of four focus groups (two with mentors and two with trainees were run during the June 2012 REDIH meeting. Surveys were administered directly after each training module. The W(eLearn framework was used as a guide to design and evaluate the program and answer the research questions. Results: The data from the analysis of the focus group interviews, in corroboration with the survey data, suggested trainees enjoyed and benefited from the REDIH experience. Trainees provided several examples of new knowledge and skills they had acquired from REDIH sessions, regarding reproductive and early developmental biology, and health. A few trainees who had been in the program for over a year provided examples of knowledge and skills acquired during the REDIH session that they were using in their place of work. Next steps will include

A >100 Ma Mantle Geochemical Record: Retiring Mantle Plumes may be Premature

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Konter, J. G.; Hanan, B. B.; Blichert-Toft, J.; Koppers, A. A.; Plank, T.; Staudigel, H.

2006-12-01

Hotspot volcanism has long been attributed to mantle plumes, but in recent years suggestions have been made that plate tectonic processes, such as extension, can account for all hotspot tracks. This explanation involves a profoundly less dynamic lower mantle, which justifies a critical evaluation before the plume model is dismissed. Such an evaluation has to involve a wide range of geochemical, geological, and geophysical techniques, broadly investigating the products of volcanism as well as the underlying lithosphere and mantle. We argue here that the combined geological record and geochemistry of intraplate volcanoes holds some important clues that help us decide between models of plume-like upwelling versus passive upwelling with lithospheric extension. The best of these integrated datasets can be obtained from the long seamount chains in the Pacific Ocean. A new combined dataset of trace element and isotopic compositions, along with modern 40Ar/39Ar ages from seamounts in the Gilbert Ridge, Tokelau chain, and West Pacific Seamount Province (WPSP) provides a record of current to Cretaceous volcanism in the South Pacific. We have reconstructed the eruptive locations of the seamounts using a range of absolute plate motion models, including some models with hotspot motion and others that use the Indo-Atlantic hotspot reference frame. Our results show that the backtracked locations consistently form clusters (300km radius) around the active ends of the Macdonald, Rurutu and Rarotonga hotspot chains, while closely matching their distinct C-HIMU and C-EM1 signatures. The oldest WPSP seamounts (older than 100 Ma) form the only exception and backtrack, with larger uncertainty, to north of Rarotonga. Therefore, the mantle currently underlying the Cook-Austral islands has produced volcanoes in three geochemically distinct areas for at least 100 m.y. Furthermore, we find the shortest mantle residence time, 0.6 Ga, for a source of mixed recycled DMM and an EM1-like

ESR dating of submarine hydrothermal activities using barite in sulfide deposition

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Toyoda, S.; Fujiwara, T.; Ishibashi, J.; Isono, Y.; Uchida, A.; Takamasa, A.; Nakai, S.

2012-12-01

The temporal change of submarine hydrothermal activities has been an important issue in the aspect of the evolution of hydrothermal systems which is related with ore formation (Urabe, 1995) and biological systems sustained by the chemical species arising from hydrothermal activities (Macdonald et al., 1980). Determining the ages of the hydrothermal deposit will provide essential information on such studies. Dating methods using disequilibrium between radioisotopes such as U-Th method (e.g. You and Bickle, 1998), 226}Ra-{210Pb and 228}Ra-{228Th method (e.g. Noguchi et al., 2011) have been applied to date submarine hydrothermal deposits. ESR (electron spin resonance) dating method is commonly applied to fossil teeth, shells, and quartz of Quaternay period where the natural accumulated dose is obtained from the intensities of the ESR signals which are created by natural radiation. The natural dose is divided by the dose rate to the mineral/sample to deduce the age. Okumura et al., (2010) made the first practical application of ESR (electron spin resonance) dating technique to a sample of submarine hydrothermal barite (BaSO4) to obtain preliminary ages, where Kasuya et al. (1991) first pointed out that barite can be used for ESR dating. Knowing that ESR dating of barite is promising, in this paper, we will present how we have investigated each factor that contributes ESR dating of barite in submarine hydrothermal sulfide deposition. (1) The best ESR condition for measuring the SO3- signal in barite is with the microwave power of 1mW and modulation amplitude of 0.1mT. (2) As results of heating experiments, the signal was found to be stable for the dating age range of several thousands. (3) 226Ra replacing Ba in barite is the source of the radiation. The amount of radioactive elements in sulfide mineral surrounding barite is negligible. (4) The external radiation from the sea water is negligible even in the submarine hydrothermal area where the radiation level is much

Quantifying Preferential Flow and Seasonal Storage in an Unsaturated Fracture-Facial Domain

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Nimmo, J. R.; Malek-Mohammadi, S.

2012-12-01

unsaturated zones [Pruess, 1999]. Lewis, M.A., H.K. Jones, D.M.J. Macdonald, M. Price, J.A. Barker, T.R. Shearer, A.J. Wesselink, and D.J. Evans (1993), Groundwater storage in British aquifers--Chalk, National Rivers Authority R&D Note, 169, Bristol, UK. Nimmo, J.R. (2010), Theory for Source-Responsive and Free-Surface Film Modeling of Unsaturated Flow, Vadose Zone Journal, 9(2), 295-306, doi:10.2136/vzj2009.0085. Price, M., R.G. Low, and C. McCann (2000), Mechanisms of water storage and flow in the unsaturated zone of the Chalk aquifer, Journal of Hydrology, 233(1-4), 54-71. Pruess, K. (1999), A mechanistic model for water seepage through thick unsaturated zones in fractured rocks of low matrix permeability, Water Resources Research, 35(4), 1039-1051.

Fire-induced risk in Andisols: An State-of-the-Art

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Neris, Jonay; Cerdà, Artemi; Santamarta, Juan C.; Doerr, Stefan

2014-05-01

-152. Mataix-Solera, J., Doerr, S.H. 2004. Hydrophobic and aggregate stability in calcareous topsoils from fire-affected pine forest in southeastern Spain. Geoderma 118, 77-88. Neris, J., Jiménez, C., Fuentes, J., Morillas, G., Tejedor, M., 2012. Vegetation and land-use effects on soil properties and water infiltration of Andisols in Tenerife (Canary Islands, Spain). Catena 98(0), 55-62. Neris, J., Tejedor, M., Fuentes, J., Jiménez, C., 2013. Infiltration, runoff and soil loss in Andisols affected by forest fire (Canary Islands, Spain). Hydrological Processes 27(19), 2814-2824. Pausas, J.G. 2004. Changes in fire and climate in the eastern Iberian Peninsula (Mediterranean basin). Climatic Change 63: 337-350. Pereira, P., Cerdà, A., Úbeda, X., Mataix-Solera, J., Martin, D., Jordán, A., Burguet, M. 2013. Spatial models for monitoring the spatio-temporal evolution of ashes after fire - a case study of a burnt grassland in Lithuania. Solid Earth, 4: 153-165. Poulenard, J., Podwojewski, P., Janeau, J.L., Collinet, J., 2001. Runoff and soil erosion under rainfall simulation of Andisols from the Ecuadorian Páramo: Effect of tillage and burning. Catena 45(3), 185-207. Prats, S.A., Malvar, M.C., Simões-Vieira, D.C., MacDonald, L., and Keizer, J.J. 2013. Effectiveness of hydromulching to reduce runoff and erosion in a recently burnt pine plantation in central Portugal. Land Degradation & Development, DOI: 10.1002/ldr.2236. Prats, S.A., Malvar, M.C., Simões-Vieira, D.C., MacDonald, L., and Keizer, J.J. 2013. Effectiveness of hydromulching to reduce runoff and erosion in a recently burnt pine plantation in central Portugal. Land Degradation & Development, DOI: 10.1002/ldr.2236. Shakesby, R.A. 2011. Post-wildfire soil erosion in the Mediterranean: Review and future research directions. Earth Science Reviews, 105, 71-100.

Evaluating the effects of dam breach methodologies on Consequence Estimation through Sensitivity Analysis

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Kalyanapu, A. J.; Thames, B. A.

2013-12-01

Dam breach modeling often includes application of models that are sophisticated, yet computationally intensive to compute flood propagation at high temporal and spatial resolutions. This results in a significant need for computational capacity that requires development of newer flood models using multi-processor and graphics processing techniques. Recently, a comprehensive benchmark exercise titled the 12th Benchmark Workshop on Numerical Analysis of Dams, is organized by the International Commission on Large Dams (ICOLD) to evaluate the performance of these various tools used for dam break risk assessment. The ICOLD workshop is focused on estimating the consequences of failure of a hypothetical dam near a hypothetical populated area with complex demographics, and economic activity. The current study uses this hypothetical case study and focuses on evaluating the effects of dam breach methodologies on consequence estimation and analysis. The current study uses ICOLD hypothetical data including the topography, dam geometric and construction information, land use/land cover data along with socio-economic and demographic data. The objective of this study is to evaluate impacts of using four different dam breach methods on the consequence estimates used in the risk assessments. The four methodologies used are: i) Froehlich (1995), ii) MacDonald and Langridge-Monopolis 1984 (MLM), iii) Von Thun and Gillete 1990 (VTG), and iv) Froehlich (2008). To achieve this objective, three different modeling components were used. First, using the HEC-RAS v.4.1, dam breach discharge hydrographs are developed. These hydrographs are then provided as flow inputs into a two dimensional flood model named Flood2D-GPU, which leverages the computer's graphics card for much improved computational capabilities of the model input. Lastly, outputs from Flood2D-GPU, including inundated areas, depth grids, velocity grids, and flood wave arrival time grids, are input into HEC-FIA, which provides the

eHealth Technologies, Multimorbidity, and the Office Visit: Qualitative Interview Study on the Perspectives of Physicians and Nurses.

Science.gov (United States)

Macdonald, Graham G; Townsend, Anne F; Adam, Paul; Li, Linda C; Kerr, Sheila; McDonald, Michael; Backman, Catherine L

2018-01-26

patients around engagement. Subthemes explain the evolution of the two-way conversation, and having, using, and supporting the two-way conversation with patients, primarily as this relates to achieving adherence and health outcomes. Emerging ethical concerns were related to the ambiguity of the ideal of empowered patients and the ways in which health professionals described enacting those ideals in practice, showing how the cultural shift toward truly mutually respectful and collaborative practice is in transition. HCPs aim to act in the best interests of their patients; the challenge is to benefit from emergent technologies that may enhance patient-HCP interactions and effective care, while abiding by regulations, dealing with the strictures of the technology itself, and managing changing demands on their time. ©Graham G Macdonald, Anne F Townsend, Paul Adam, Linda C Li, Sheila Kerr, Michael McDonald, Catherine L Backman. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 26.01.2018.

Real-world effectiveness of valsartan on hypertension and total cardiovascular risk: review and implications of a translational research program

Directory of Open Access Journals (Sweden)

Abraham I

2011-03-01

Full Text Available Ivo Abraham1,2, Karen MacDonald2, Christine Hermans3, Ann Aerts3, Christopher Lee2,4, Heidi Brié3, Stefaan Vancayzeele31Center for Health Outcomes and Pharmacoeconomic Research, and Department of Pharmacy Practice and Science, College of Pharmacy, The University of Arizona, Tucson, AZ, USA; 2Matrix45, Earlysville, VA, USA; 3Novartis Pharma, Vilvoorde, Belgium; 4School of Nursing, Oregon Health and Science University, Portland, OR, USAAbstract: The pharmacological efficacy of various monotherapy, single pill, and combination therapies of the angiotensin II receptor blocker valsartan have been established, mainly through randomized controlled trials that used similar methodological and statistical platforms and thus enabled synthesis of evidence. The real world effectiveness of valsartan has been studied extensively, but the relative lack of scientific and technical congruence of these studies render synthesis virtually impossible. To date, all have focused on blood pressure outcomes, despite evidence-based calls to grade antihypertensive treatment to patients' total cardiovascular risk. We review a T3 translational research program of seven studies involving valsartan monotherapy as well as single and separate pill combinations, and the determinants and effect on blood pressure and total cardiovascular risk outcomes. All seven studies examined not only the impact of valsartan-based regimens on blood pressure values and control, but also, within a statistical hierarchical approach, the physician- and patient-related determinants of these blood pressure outcomes. Two studies also investigated the determinants and outcomes of valsartan-based treatment on total cardiovascular risk – among the first studies to use this risk coefficient as an outcome rather than only a determinant. These seven studies included a total of 19,533 patients, contributed by 3434 physician-investigators in Belgium – a country particularly well-suited for observational

Research Experiences in Community College Science Programs

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Beauregard, A.

2011-12-01

The benefits of student access to scientific research opportunities and the use of data in curriculum and student inquiry-driven approaches to teaching as effective tools in science instruction are compelling (i.e., Ledley, et al., 2008; Gawel & Greengrove, 2005; Macdonald, et al., 2005; Harnik & Ross. 2003). Unfortunately, these experiences are traditionally limited at community colleges due to heavy faculty teaching loads, a focus on teaching over research, and scarce departmental funds. Without such hands-on learning activities, instructors may find it difficult to stimulate excitement about science in their students, who are typically non-major and nontraditional. I present two different approaches for effectively incorporating research into the community college setting that each rely on partnerships with other institutions. The first of these is a more traditional approach for providing research experiences to undergraduate students, though such experiences are limited at community colleges, and involves student interns working on a research project under the supervision of a faculty member. Specifically, students participate in a water quality assessment study of two local bayous. Students work on different aspects of the project, including water sample collection, bio-assay incubation experiments, water quality sample analysis, and collection and identification of phytoplankton. Over the past four years, nine community college students, as well as two undergraduate students and four graduate students from the local four-year university have participated in this research project. Aligning student and faculty research provides community college students with the unique opportunity to participate in the process of active science and contribute to "real" scientific research. Because students are working in a local watershed, these field experiences provide a valuable "place-based" educational opportunity. The second approach links cutting-edge oceanographic

Landing Marine-derived Renewable Energy: Optimising Power Cable Routing in the Nearshore Environment

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Turner, Rosalind, ,, Dr.; Keane, Tom; Mullins, Brian; Phipps, Peter

2010-05-01

Numerous studies have demonstrated that a vast unexploited source of energy can be derived from the marine environment. Recent evolution of the energy market and looming EU renewable energy uptake targets for 2020 have driven a huge explosion of interest in exploiting this resource, triggering both governments and industry to move forward in undertaking feasibility assessments and demonstration projects for wave, tidal and offshore wind farms across coastlines. The locations which naturally lend themselves to high yield energy capture, are by definition, exposed and may be remote, located far from the end user of the electricity generated. A fundamental constraint to successfully exploiting these resources will be whether electricity generated in high energy, variable and constantly evolving environments can be brought safely and reliably to shore without the need for constant monitoring and maintenance of the subsea cables and landfall sites. In the case of riverine cable crossings superficial sediments would typically be used to trench and bury the cable. High energy coastal environments may be stripped of soft sediments. Any superficial sediments present at the site may be highly mobile and subject to re-suspension throughout the tidal cycle or under stormy conditions. EirGrid Plc. and Mott MacDonald Ireland Ltd. have been investigating the potential for routing a cable across the exposed Shannon estuary in Ireland. Information regarding the geological ground model, meteo-oceanographic and archaeological conditions of the proposed site was limited, necessitating a clear investigation strategy. The investigation included gathering site information on currents, bathymetry and geology through desk studies, hydrographic and geophysical surveys, an intrusive ground investigation and coastal erosion assessments at the landfall sites. The study identified a number of difficulties for trenching and protecting a cable through an exposed environment such as the Shannon

Mobile Application to Promote Adherence to Oral Chemotherapy and Symptom Management: A Protocol for Design and Development.

Science.gov (United States)

Fishbein, Joel Nathan; Nisotel, Lauren Ellen; MacDonald, James John; Amoyal Pensak, Nicole; Jacobs, Jamie Michele; Flanagan, Clare; Jethwani, Kamal; Greer, Joseph Andrew

2017-04-20

symptoms and side effects. At every stage in this trial, we are engaging stakeholders to solicit feedback on our progress and next steps. To our knowledge, we are the first to describe the development of an app designed for people taking oral chemotherapy. The app addresses many concerns with oral chemotherapy, such as medication adherence and symptom management. Soliciting feedback from stakeholders with broad perspectives and expertise ensured that the app was acceptable and potentially beneficial for patients, caregivers, and clinicians. In our development process, we instantiated 7 of the 8 best practices proposed in a recent review of mobile health app development. Our process demonstrated the importance of effective communication between research groups and technical teams, as well as meticulous planning of technical specifications before development begins. Future efforts should consider incorporating other proven strategies in software, such as gamification, to bolster the impact of mobile health apps. Forthcoming results from our randomized controlled trial will provide key data on the effectiveness of this app in improving medication adherence and symptom management. ClinicalTrials.gov NCT02157519; https://clinicaltrials.gov/ct2/show/NCT02157519 (Archived by WebCite at http://www.webcitation.org/6prj3xfKA). ©Joel Nathan Fishbein, Lauren Ellen Nisotel, James John MacDonald, Nicole Amoyal Pensak, Jamie Michele Jacobs, Clare Flanagan, Kamal Jethwani, Joseph Andrew Greer. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 20.04.2017.

CH4 fluxes across the seafloor at three district gas hydrate fields: Impacts on ocean and atmosphere chemistry

Energy Technology Data Exchange (ETDEWEB)

Kastner, M.; Bartlett, D.; MacDonald, I.; Solomon, E.

2005-07-01

maximum of 90% of the water column methane is aerobically oxidized. Above the methane plumes associated with the hydrate mound at BH methane concentrations in surface water are 200-500 times the equilibrium value, and delta{sup 13}C- DIC is depleted relative to the background value, indicating a net methane flux to the atmosphere. An estimate of the regional GOM methane flux to the atmosphere when extrapolated over the approx. 400 plumes having persistent oil slicks on the ocean surface, mapped by time series satellite data, is approx. 0.5 Tg/year (Leifer and MacDonald, 2003) Pore fluid delta{sup 13}C-DIC indicate that at HR (both, the North and South Ridges) microbially mediated anaerobic oxidation of methane (AOM) is the dominant reaction in the sub-seafloor; the lightest delta{sup 13}C-DIC value we measured is approx. 51, PDB. At BH, however, at and near the active methane vents associated with the hydrate mound, oil oxidation and not AOM is the dominant reaction in the sub-seafloor, with a minimum pore fluid delta{sup 13}C-DIC value of approx. 21, PDB. (Author)

Book Reviews

Directory of Open Access Journals (Sweden)

Redactie KITLV

2008-12-01

Full Text Available Benedict Anderson; Under three flags; Anarchism and the anticolonial imagination (Greg Bankoff Leakthina Chau-Pech Ollier, Tim Winter (eds; Expressions of Cambodia; The politics of tradition, identity and change (David Chandler Ying Shing Anthony Chung; A descriptive grammar of Merei (Vanuatu (Alexandre François Yasuyuki Matsumoto; Financial fragility and instability in Indonesia (David C. Cole Mason C. Hoadley; Public administration; Indonesian norms versus Western forms (Jan Kees van Donge Samuel S. Dhoraisingam; Peranakan Indians of Singapore and Melaka (Joseph M. Fernando Vatthana Pholsena; Post-war Laos; The politics of culture, history and identity (Volker Grabowksy Gert Oostindie; De parels en de kroon; Het koningshuis en de koloniën (Hans Hägerdal Jean-Luc Maurer; Les Javanais du Caillou; Des affres de l’exil aux aléas de l’intégration; Sociologie historique de la communauté indonésienne de Nouvelle-Calédonie (Menno Hecker Richard Stubbs; Rethinking Asia’s economic miracle; The political economy of war, prosperity and crisis (David Henley Herman Th. Verstappen; Zwerftocht door een wereld in beweging (Sjoerd R. Jaarsma Klokke, A.H. (ed. and transl.; Fishing, hunting and headhunting in the former culture of the Ngaju Dayak in Central Kalimantan; Notes from the manuscripts of the Ngaju Dayak authors Numan Kunum and Ison Birim; from the Legacy of Dr. H. Schaerer; With a recent additional chapter on hunting by Katuah Mia (Monica Janowski Ian Proudfoot; Old Muslim calendars of Southeast Asia (Nico J.G. Kaptein Garry Rodan; Transparency and authoritarian rule in Southeast Asia (Soe Tjen Marching Greg Fealy, Virginia Hooker (eds; Voices of Islam in Southeast Asia; A contemporary sourcebook (Dick van der Meij Eko Endarmoko; Tesaurus Bahasa Indonesia (Don van Minde Charles J.-H. Macdonald; Uncultural behavior; An anthropological investigation of suicide in the southern Philippines

Geologic Map of the State of Hawai`i

Science.gov (United States)

Sherrod, David R.; Sinton, John M.; Watkins, Sarah E.; Brunt, Kelly M.

2007-01-01

About This Map The State's geology is presented on eight full-color map sheets, one for each of the major islands. These map sheets, the illustrative meat of the publication, can be downloaded in pdf format, ready to print. Map scale is 1:100,000 for most of the islands, so that each map is about 27 inches by 36 inches. The Island of Hawai`i, largest of the islands, is depicted at a smaller scale, 1:250,000, so that it, too, can be shown on 36-inch-wide paper. The new publication isn't limited strictly to its map depictions. Twenty years have passed since David Clague and Brent Dalrymple published a comprehensive report that summarized the geology of all the islands, and it has been even longer since the last edition of Gordon Macdonald's book, Islands in the Sea, was revised. Therefore the new statewide geologic map includes an 83-page explanatory pamphlet that revisits many of the concepts that have evolved in our geologic understanding of the eight main islands. The pamphlet includes simplified page-size geologic maps for each island, summaries of all the radiometric ages that have been gathered since about 1960, generalized depictions of geochemical analyses for each volcano's eruptive stages, and discussion of some outstanding topics that remain controversial or deserving of additional research. The pamphlet also contains a complete description of map units, which enumerates the characteristics for each of the state's many stratigraphic formations shown on the map sheets. Since the late 1980s, the audience for geologic maps has grown as desktop computers and map-based software have become increasingly powerful. Those who prefer the convenience and access offered by Geographic Information Systems (GIS) can also feast on this publication. An electronic database, suitable for most GIS software applications, is available for downloading. The GIS database is in an Earth projection widely employed throughout the State of Hawai`i, using the North American datum of

Study of the interaction operator between two groups of particles in a completely ionised plasma. Development of the distribution functions in a series of orthogonal polynomials (1963); Etude de l'operateur d'interaction entre deux groupes de particules dans un plasma completement ionise. Developpement des fonctions de distribution en series de polynomes orthogonaux (1963)

Energy Technology Data Exchange (ETDEWEB)

Fain, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1963-05-15

A completely ionised medium is considered in which the variations of the distribution functions for each species of particles is governed by the Fokker-Planck equation. The interaction operator is of a form given by Rosenbluth - Macdonald - Judd. The distribution functions are expanded into orthogonal polynomial series in the velocity space. In a first stage these functions are first split up into spherical harmonic series (or, in an equivalent form, into series of scalar products of irreducible cartesian tensors), with coefficients which are a function of the velocity modulus as well as space and time coordinates. In the second stage these coefficients are expanded into series of orthogonal functions of the velocity modulus; the 1 order harmonic is represented by the product of a Maxwell distribution and of a SONINE polynomial series, having an index of 1 + 1 / 2, which have as variable the reduced energy of the particles (in terms of a basic temperature), with coefficients which then only depend on the space and time coordinates. In the first part the relationship is established between the expansion coefficients and the moments of the distribution function, as well as the hydrodynamic values. In the second part the expansion using spherical harmonics is applied to the Fokker-Planck equation. The general expression for the second member is given as well as the particular expressions corresponding to the cases where the operator is linearized. In the third part the complete expansion in orthogonal polynomial series is applied to the Fokker-Planck equation. The expression of the generating functions is given for all the harmonics in the case of the linearized operator, as well as the transport equations for the first four harmonics. (author) [French] On considere un milieu completement ionise ou l'evolution des fonctions de distribution pour chaque espece de particules est regie par l'equation de FOKKER-PLANCK. L'operateur d'interaction se met sous la forme

Nornahraun lava morphology and mode of emplacement

Science.gov (United States)

Pedersen, Gro B. M.; Höskuldsson, Armann; Riishuus, Morten S.; Jónsdóttir, Ingibjörg; Gudmundsson, Magnús T.; Sigmundsson, Freysteinn; Óskarsson, Birgir V.; Drouin, Vincent; Gallagher, Catherine; Askew, Rob; Moreland, William M.; Dürig, Tobias; Dumont, Stephanie; Þórdarson, Þór

2015-04-01

and the flow front came to halt on 12 SEPT 18 km from the source vent. Subsequently, a new lobe broke out S of the first lobe and migrated eastward until it came to a halt at a slightly shorter distance from the fissure. This mode of gradual clockwise propagation of new frontal lobes continued from mid-SEPT to end-NOV. Around 15 OCT, a ~0.8 km2 lava pond developed and persists into 2015. As the activity on the southern front dwindled toward end-NOV, verti-cal stacking of insulated flows had commenced and reached the edge of northern front on 26 NOV. Prior to that the entire northern flow front had hardly advanced for two weeks. The main lava channel partly crusted over and by end-NOV a series of insulated flows were overriding the previous emplaced flows, changing transport system to include closed/insultaed pathways in addition to open channels. Resultantly, the area now covered by the flow field has undergone several topographic inversions due to stacking of lava lobes. [1] Macdonald (1967) NY Wiley, 1-61. [2] Swanson (1973) GSAB, 84, 615-626. [3] Thordarson (2000) Surtsey Res. Prog. Rep., XI, 125-142. [4] Guilbaud et al. (2005) Geol. Soc. Am. Spec. Pap., 396, 81-102. [5] Keszthelyi et al. (2004) GGG, 5, Q11014.

Enhancing international earth science competence in natural hazards through 'geoNatHaz

Science.gov (United States)

Giardino, Marco; Clague, John J.

2010-05-01

Research Institute on Hydrogeological Hazards; Simon Fraser University Centre for Natural Hazard Research; Civil Protection of Regione Piemonte; Dipartimento Difesa del Suolo of Regione Valle d'Aosta; Environmental Protection, Civil Protection and Geological Survey of Regione Emilia-Romagna; Alberta Geological Survey), non-governmental and non-profit organizations (Fondazione Vaiont; Fondation Montaine Sure; Comitato Glaciologico Italiano; Tele-Rilevamento Europa; IMAGEO), and companies (MacDonald, Detwiller and Associates; TRE-Canada; BC Hydro; CVA). Support programs to ensure that students fully benefit from their exchanges are in place in each of the participating universities. Exchanges of faculty and technicians will ensure that students' educational experiences are challenging, rich, and intellectually rewarding. The exchanges also will facilitate development of up-to-date natural hazard courses shared by the seven partner universities and will catalyze collaborations among scientists participating in the project. The centrepiece of the project is field-based courses in natural hazards and risk in high mountain environments. Six field courses will be offered over the three-year period of the project - three in Europe and three in Canada. Course topics include (1) impacts of climate change on natural hazards in high mountains, (2) deep-seated rock-slope deformation, (3) mitigation of landslide hazards in mountain valleys, (4) applications of new technologies in natural hazard research, (5) frequency-magnitude relations and risk assessment, and (6) earthquake hazards and risk in mountain regions. The courses are taught by faculty from each of the partner universities, with the assistance of graduate students and technicians. The field courses support and extend existing programs in geology, geomorphology, and engineering geology offered by the partner universities.

Universal Themes of Bose-Einstein Condensation

Science.gov (United States)

Proukakis, Nick P.; Snoke, David W.; Littlewood, Peter B.

2017-04-01

-Einstein condensation of photons and grand-canonical condensate fluctuations J. Klaers and M. Weitz; 20. Laser operation and Bose-Einstein condensation: analogies and differences A. Chiocchetta, A. Gambassi and I. Carusotto; 21. Vortices in resonant polariton condensates in semiconductor microcavities D. N. Krizhanovskii, K. Guda, M. Sich, M. S. Skolnick, L. Dominici and D. Sanvitto; 22. Optical control of polariton condensates G. Christmann, P. G. Savvidis and J. J. Baumberg; 23. Disorder, synchronization and phase-locking in non-equilibrium Bose-Einstein condensates P. R. Eastham and B. Rosenow; 24. Collective topological excitations in 1D polariton quantum fluids H. Terças, D. D. Solnyshkov and G. Malpuech; 25. Microscopic theory of Bose-Einstein condensation of magnons at room temperature H. Salman, N. G. Berloff and S. O. Demokritov; 26. Spintronics and magnon Bose-Einstein condensation R. A. Duine, A. Brataas, S. A. Bender and Y. Tserkovnyak; 27. Spin-superfluidity and spin-current mediated non-local transport H. Chen and A. H. MacDonald; 28. Bose-Einstein condensation in quantum magnets C. Kollath, T. Giamarchi and C. Rüegg; Part V. Condensates in Astrophysics and Cosmology: Editorial notes; 29. Bose-Einstein condensates in neutron stars C. J. Pethick, T. Schäfer and A. Schwenk; 30. A simulated cosmological metric: the superfluid 3He condensate G. R. Pickett; 31. Cosmic axion Bose-Einstein condensation N. Banik and P. Sikivie; 32. Graviton BECs: a new approach to quantum gravity G. Dvali and C. Gomez; Universal Bose-Einstein condensation workshop; Index.

Real-world variability in ranibizumab treatment and associated clinical, quality of life, and safety outcomes over 24 months in patients with neovascular age-related macular degeneration: the HELIOS study

Directory of Open Access Journals (Sweden)

Rakic JM

2013-09-01

Full Text Available Jean-Marie Rakic,1 Anita Leys,2 Heidi Brié,3 Kris Denhaerynck,4 Christy Pacheco,4 Stefaan Vancayzeele,3 Christine Hermans,3 Karen MacDonald,4 Ivo Abraham4,5 1Department of Ophthalmology, Centre Hospitalier Universitaire de Liège, Site du Sart Tilman, Liège, Belgium; 2Leuven University Eye Hospital, Leuven, Belgium; 3Novartis Pharma, Vilvoorde, Belgium; 4Matrix45, Tucson, AZ, USA; 5Center for Health Outcomes and Pharmacoeconomic Research, University of Arizona, Tucson, AZ, USA Introduction: The aim of this study was to examine ranibizumab treatment patterns in "real-world" practice and clinical settings, as well as to assess quality of life outcomes over a 24-month period. Materials and methods: This was a prospective, observational, multicenter, open-label study of 0.5 mg of ranibizumab administered intravitreally. Patients were followed over 24 ± 3 months with intermediate data points at 6 ± 2 months and 12 ± 2 months, and a limited data point at 2.5 ± 1 month that coincided with the end of the loading phase. Outcomes included visual acuity (Early Treatment Diabetic Retinopathy Study, visual function (National Eye Institute Visual Function Questionnaire-25 [NEI VFQ-25], quality of life (Health Utilities Index Mark III [HUI3], and safety. Results: A total of 267 patients with wet age-related macular degeneration (mean ± standard deviation [SD] age = 78.5 ± 7.3 years; 62.4% were female; 34.5% with dual eye involvement; 74.9% were treatment-naïve were treated (309 eyes were treated. The mean ± SD Early Treatment Diabetic Retinopathy Study score at baseline was 56.3 ± 14.3 letters. The mean ± SD number of injections over 24 months was 7.6 ± 4.1, including 2.5 ± 0.7 and 5.9 ± 3.6 during the loading and maintenance phases, respectively, with corresponding treatment intervals of 4.8 ± 1.4 weeks and 11.5 ± 9.5 weeks, respectively. Improvements in visual acuity over baseline were reached at 2.5 months and maintained at 6 months (both P

Implications of a Caldera Origin of the Lunar Crater Copernicus

Science.gov (United States)

Green, J.

2007-12-01

The forthcoming renaissance in lunar exploration will focus on many objectives such as Copernicus. Copernicus appears to be a caldera for at least 8 reasons. If a caldera we see (1) transient activity (2) no overturned impact flap at the crater margins (3) internal sinuous leveed lava flow channels (4) a lava covered floor (5) terraces of different ages (6) multiple central volcanoes, one showing a directed volcanic blast (7) olivine-rich komatiitic lavas on central volcanoes and (8) magmatic inflation/deflation on caldera flanks localizing craterlets and extinct fumaroles in "loop" patterns. Regarding (6), directed volcanic blasts can remove a segment of the volcano wall as evidenced in terrestrial analogs at Mt. St. Helens and Bezymianny. Impact mechanisms to produce this feature in Copernicus are contrived. For (7) Clementine spectral data show a high olivine content of the central mountains on Copernicus which I interpret as forsteritic spinifex mineralization in komatiitic lavas and not as impact rebound of olivine-rich deep seated rocks. (8) MacDonald (1956) documented loop patterns on the flank of Halemaumau in Hawaii defining arcuate fractures localizing fumaroles and craterlets. Inflation/deflation of subjacent magma bodies are interpreted as the cause for these loops. Inflation/deflation mechanisms on caldera flanks are common around terrestrial calderas. "Loop" patterns on the flank of Copernicus localizing "gouge" craterlets have been interpreted as ballistic features resulting from the meteorite impact of this crater. Questioned is the logic of a linear N26E trending array of fragments within Copernicus to serve as a source of ballistic projectiles to form the loops localizing conjugate craterlets. The fused craterlet axes on the lunar loops do not point back to a presumed impact center in Copernicus. The axes are oriented parallel to a regional northwest (N35-60W) fracture zone. Implications for an endogenic origin of Copernicus would involve

The Payun-Matru lava field: a source of analogues for Martian long lava flows

Science.gov (United States)

Giacomini, L.; Pasquarè, G.; Massironi, M.; Frigeri, A.; Bistacchi, A.; Frederico, C.

2007-08-01

this hypothesis. According to this view some linear features at the flow surface can be interpreted as squeeze-ups. They can be generated by vertical growth and fracturing of the sealing crust followed by effusion of hot lava continuously injected beneath the flow surface. In addition some lava tubes were also detected thanks to several aligned pits produced by partial tube collapse. Tumuli are certainly one of the most representative features of inflation mechanism [5], but their unambiguous detection is very difficult for the inadequate resolution of the available images. Nonetheless some tumuli like features has been already detected by Glaze and co-workers (2005) [10] in the regions surroundings Elysium Mons and in this work we have detect similar features in the Tharsis region, at Ascraeus Mons lava field. Finally Zephyria and Elysium Planitia show particular platy flows that can be compared with flat topped lava rise found on Payun flows. In addition in Zephyria flows as well in the Payun ones elongated narrow ridges can be observed near the border of the sheetflow and especially near the isolated pre-existent hills surrounded by the lava flow. Their spatial arrangements suggests that they originated from lateral compression inside the visco-elastic deformation of lava crust under the influence of the above mentioned obstacles. In this case these features should correspond to pressure ridges in the sense of MacDonald (1972) [11]. All these examples suggest that inflation. spreading mechanism is present also for some Martian flows. By contrast, the Olympus Mons slopes are mainly covered by lava flows with lobes, tubes (often partially collapsed) and numerous channels that are very similar to channelized flows developed from Carbonilla Fault during the last eruption cycles of Payun Matru complex. References [1]Pasquarè G., Bistacchi A., Mottana A., 2005. Gigantic individual lava flows in the Andean foothills near Malargüe (Mendoza, Argentina). Rendiconti dell

Adjuvant treatment of gastric cancer in a long term follow-up Tratamento adjuvante no câncer gástrico em seguimento a longo prazo

Directory of Open Access Journals (Sweden)

Miriam Honda Federico

2009-03-01

Full Text Available BACKGROUND: Advanced gastric cancer carries a poor-prognosis. The best extent of the node dissection and the value of postoperative adjuvant treatments remain open questions. AIM: To study the efficacy of adjuvant chemoradiation and the prognostic value of some clinico-pathological variables in gastric cancer previously submitted to surgery. METHODS: Retrospective single institution study of 69 patients with histological diagnoses of gastric adenocarcinoma, consecutively submitted to radical surgery with curative intent in a five years period. Lymph node dissection was either D1 or D2 at the surgeon's description. All patients were submitted to adjuvant chemoradiation according to MacDonald et al.². Treatment discontinuation and early deaths were considered as serious toxic events. Clinical-pathological variables (the extent D level of the node dissection, T/N-stage, histological subtype, margin status, number of the dissected nodes were correlated to the results. Overall survival was estimated according to the Kaplan-Meier method and the curves were compared by the log-rank test. RESULTS: Patients characteristics: 48 male/21 female, median age 56,4 y (30-79. In 25 patients, the extent of node dissection was D1, in 41 was D2 and D0 in 3. Staging (n: T2 (16; T3 (49; T4 (4; No (11; N1 (29; N2 (20; N3 (8; Nx (1. Histological subtype: intestinal (45, diffuse (19 and unknown (5. Margins were free in 57 patients, the median number of dissected nodes was 31 (0-120. They were treated with linear acelerator 6 MV photons, AP/PA fields with 45Gy in 5 weeks in 90% of the patients and the treatment was done in a mean time of 19,2 weeks. In the median follow-up of 19,3mo (8-52,5mo, 52 patients with more than 24 months of follow-up occurred 38 deaths. The median overall survival for all patients was 22,2 months. Seven (10% patients presented serious toxic events and treatment was discontinued. Six (8,6% refused to continue the treatment. The acute toxicity

Geologic map of the northeast flank of Mauna Loa volcano, Island of Hawai'i, Hawaii

Science.gov (United States)

Trusdell, Frank A.; Lockwood, John P.

2017-05-01

SummaryMauna Loa, the largest volcano on Earth, has erupted 33 times since written descriptions became available in 1832. Some eruptions were preceded by only brief seismic unrest, while others followed several months to a year of increased seismicity.The majority of the eruptions of Mauna Loa began in the summit area (>12,000-ft elevation; Lockwood and Lipman, 1987); yet the Northeast Rift Zone (NERZ) was the source of eight flank eruptions since 1843 (table 1). This zone extends from the 13,680-ft-high summit towards Hilo (population ~60,000), the second largest city in the State of Hawaii. Although most of the source vents are farther than 30 km away, the 1880 flow from one of the vents extends into Hilo, nearly reaching Hilo Bay. The city is built entirely on flows erupted from the NERZ, most older than that erupted in 1843.Once underway, Mauna Loa's eruptions can produce lava flows that reach the sea in less than 24 hours, severing roads and utilities in their path. For example, lava flows erupted from the Southwest Rift Zone (SWRZ) in 1950 advanced at an average rate of 9.3 km per hour, and all three lobes reached the ocean within approximately 24 hours (Finch and Macdonald, 1953). The flows near the eruptive vents must have traveled even faster.In terms of eruption frequency, pre-eruption warning, and rapid flow emplacement, Mauna Loa poses an enormous volcanic-hazard threat to the Island of Hawai‘i. By documenting past activity and by alerting the public and local government officials of our findings, we can anticipate the volcanic hazards and substantially mitigate the risks associated with an eruption of this massive edifice.From the geologic record, we can deduce several generalized facts about the geologic history of the NERZ. The middle to the uppermost section of the rift zone were more active in the past 4,000 years than the lower part, perhaps due to buttressing of the lower east rift zone by Mauna Kea and Kīlauea volcanoes. The historical flows

Investigation of the possible connection of rock and soil geochemistry to the occurrence of high rates of neurodegenerative diseases on Guam and a hypothesis for the cause of the diseases

Science.gov (United States)

Miller, William R.; Sanzolone, Richard F.

2003-01-01

have neurotoxic effects (MacDonald and Martin, 1988), and aluminum has been implicated in the pathogenesis of Alzheimer’s disease and similar dementia by Perl and others (1982). Studies of soils developed on volcanic rocks on Guam and other islands by McLachlan and others (1989) found that soils on Guam averaged 42-fold higher yield of elutable aluminum than soils developed on volcanic rocks on Jamaica or Palau. They did not detect unusually high dietary aluminum or low dietary calcium, but concluded that the soils and possibly the dusts of Guam might be a major source of aluminum entering the body of the inhabitants. This study was conducted to investigate the geochemistry of the soils and rocks of the volcanic southern part of the island of Guam, particularly in the vicinity of the three southern villages (Umatac, Merizo, and Inarajan) with high incidences of the diseases. In addition to total chemical analyses of the soils and rocks, various extractions of soils were carried out. Both excesses and deficiencies of various elements were looked for. Because soluble aluminum in the soil was shown by McLachlan and others (1989) to be unusually high, water-soluble extractions as well as sequential extractions of the soils were carried out. In addition, elements such as aluminum found in dust can traverse the nose-brain barrier in experimental animals (Sunderman, 2000) and respiratory epithelium is known to contain the highest concentration of aluminum in the human body (Tipton and others, 1957). The availability of elements, particularly aluminum from human inhalation of dust, derived from soil, was investigated. The available elements were determined by extractions of soils using a simulated lung-fluid extraction.In order to compare the results of the chemical data of rocks and soils from Guam to other rocks and soils elsewhere, samples of similar rocks and soils were collected in the western United States and similar analyses to those for the Guam samples carried out

Evaluation of the toxicity of sediments from the Anniston PCB Site to the mussel Lampsilis siliquoidea

Science.gov (United States)

Schein, Allison; Sinclair, Jesse A.; MacDonald, Donald D.; Ingersoll, Christopher G.; Kemble, Nile E.; Kunz, James L.

2015-01-01

concentrations of PCBs were associated with the highest concentrations of PAHs, PCDDs/PCDFs, and organochlorine pesticides. Specifically, sediments 08, 18, and 19 exceeded probable effect concentration quotients (PEC-Qs) of 1.0 for all organic classes of contaminants. These three sediment samples also had high concentrations of mercury and lead, which were the only metals found at elevated concentrations (i.e., above the probable effect concentration [PEC]) in the samples collected. Many sediment samples were highly contaminated with mercury, based on comparisons to samples collected from reference locations. The whole-sediment laboratory toxicity tests conducted with L. siliquoidea met the test acceptability criteria (e.g., control survival was greater than or equal to 80%). Survival of mussels was high in most samples, with 4 of 23 samples (17%) classified as toxic based on the survival endpoint. Biomass and weight were more sensitive endpoints for the L. siliquoidea toxicity tests, with both endpoints classifying 52% of the samples as toxic. Samples 19 and 30 were most toxic to L. siliquoidea, as they were classified as toxic according to all four endpoints (survival, biomass, weight, and length). Mussels were less sensitive in toxicity tests conducted with sediments from the Anniston PCB Site than Hyalella azteca and Chironomus dilutus. Biomass of L. siliquoidea was less sensitive compared to biomass of H. azteca or biomass of larval C. dilutus. Based on the most sensitive endpoint for each species, 52% of the samples were toxic to L. siliquoidea, whereas 67% of sediments were toxic to H. azteca (based on reproduction) and 65% were toxic to C. dilutus (based on adult biomass). The low-risk toxicity threshold (TTLR) was higher for L. siliquoidea biomass (e.g., 20,400 µg/kg dry weight [DW]) compared to that for H. azteca reproduction (e.g., 499 µg/kg DW) or C. dilutus adult biomass (e.g., 1,140 µg/kg DW; MacDonald et al. 2014). While mussels such as L. sili

PREFACE: 13th International Conference on Muon Spin Rotation, Relaxation and Resonance

Science.gov (United States)

2014-12-01

submitted 227 contributions, which were intensively discussed during day and evening sessions. The scientific program was centered around invited talks from speakers outside the μSR community, who presented lectures on topics where μSR is giving or expected to give significant contributions. The invited speakers, covering various fields of interest, included Radu Coldea (Oxford, Quantum Magnetism), Claude- Henri Delmas (Bordeaux, Electro- and Solid State Chemistry), Dirk Johrendt (Munich, Iron Based Materials), Marc-Henri Julien (Grenoble, Cuprate Superconductors), Manfred Fiebig (Zürich, Multiferroics), Allan MacDonald (Austin, Topological Electronic States), Hidenori Takagi (Stuttgart and Tokyo, Transition Metal Oxides), and Jean-Marc Triscone (Geneva, Oxide Heterostructures). In addition to an overview about status and progress of the existing facilities in Europe, Canada and Japan, future projects and new ideas for μSR facilities in South Korea, China and the USA were presented. A special evening session was held to discuss about muon site and muon states calculations by DFT and other techniques. Several talks and posters can be found on the conference web page www.psi.ch/muSR2014. In a ceremony at the beginning of the conference, Roberto De Renzi from the University of Parma was awarded the 2014 Yamazaki Prize for muon science by the International Society for Muon Spin Spectroscopy (ISMS) for his sustained and exceptional contributions to the development of the muon spin relaxation technique to investigate magnetism and superconductivity and for promoting synergies between μSR and NMR. In the closing session Rob Kie (UBC Vancouver and TRIUMF) very effectively summarized the five days of meeting, while giving an enlightening personal impression. In the same session five best poster prizes were awarded and ISMS gave two prizes to young researchers presenting outstanding work at the conference. The conference organizers also on behalf of the entire μSR community are

U.S. Geological Survey scientific activities in the exploration of Antarctica: 1946-2006 record of personnel in Antarctica and their postal cachets: U.S. Navy (1946-48, 1954-60), International Geophysical Year (1957-58), and USGS (1960-2006)

Science.gov (United States)

Meunier, Tony K.; Williams, Richard S.; Ferrigno, Jane G.

2007-01-01

Antarctica, a vast region encompassing 13.2 million km2 (5.1 million mi2), is considered to be one of the most important scientific laboratories on Earth. During the past 60 years, the USGS, in collaboration and with logistical support from the National Science Foundation's Office of Polar Programs, has sent 325 USGS scientists to Antarctica to work on a wide range of projects: 169 personnel from the NMD (mostly aerial photography, surveying, and geodesy, primarily used for the modern mapping of Antarctica), 138 personnel from the GD (mostly geophysical and geological studies onshore and offshore), 15 personnel from the WRD (mostly hydrological/glaciological studies in the McMurdo Dry Valleys), 2 personnel from the BRD (microbiological studies in the McMurdo Dry Valleys), and 1 person from the Director's Office (P. Patrick Leahy, Acting Director, 2005–06 austral field season). Three GD scientists and three NMD scientists have carried out field work in Antarctica 9 or more times: John C. Behrendt (15), who started in 1956–57 and published two memoirs (Behrendt, 1998, 2005), Arthur B. Ford (10), who started in 1960–61, and Gary D. Clow (9), who started in 1985–86; Larry D. Hothem (12), who began as a winter-over geodesist at Mawson Station in 1968–69, and Jerry L. Mullins (12), who started in 1982–83 and followed in the legendary footsteps of his NMD predecessor, William R. MacDonald (9), who started in 1960–61 and supervised the acquisition of more than 1,000,000 square miles of aerial photography of Antarctica. This report provides a record as complete as possible, of USGS and non-USGS collaborating personnel in Antarctica from 1946–2006, the geographic locations of their work, and their scientific/engineering disciplines represented. Postal cachets for each year follow the table of personnel and scientific activities in the exploration of Antarctica during those 60 years. To commemorate special events and projects in Antarctica, it became an

Boundary issues

Science.gov (United States)

Townsend, Alan R.; Porder, Stephen

2011-03-01

-centric boundary (Filippelli 2008, Handoh and Lenton 2003). However, human alteration of the P cycle has multiple potential boundaries (figure 1), including P-driven freshwater eutrophication (Smith and Schindler 2009), the potential for world P supply to place an ultimate limit on food production (Smil 2000, Childers et al 2011), and depletion of soil P stocks in some world regions (MacDonald et al 2011). Carpenter and Bennett revisit the P boundary from the freshwater eutrophication perspective. Given the extraordinary variation in freshwater ecosystems across the globe, this is a challenging task, but the authors strengthen their analysis by using three different boundaries with relevance to eutrophication, along with two water quality targets and a range of estimates of P flow to the sea. In doing so, they make a compelling case that if freshwater eutrophication is indeed a Rubicon, we have already crossed it. Importantly, Carpenter and Bennett go beyond the calculation of new boundaries to make broader points about humanity's relationship with the P cycle. Disruptions of both the P and N cycles are mostly about our need for food (Galloway et al 2008, Cordell et al 2009), but unlike N, P supplies are finite and irreplaceable. Environmental concerns aside, we can fix all the N2 from the atmosphere we want—but deplete our economically viable P reserves and we're in trouble. Figure 1 Figure 1. Human alteration of the global P cycle has multiple possible boundaries. These include the environmental risks posed by freshwater eutrophication and marine anoxic events, and the food security risks that come from depletion of soil P stocks in some world regions, as well as finite global supplies of high-value mineral P reserves. Photo credits beyond authors: upper left, Shelby Riskin; upper right, Pedro Sanchez. In effect, Carpenter and Bennett argue that among P's multiple boundaries, the one for freshwaters is less forgiving of our current activities (but no less important) than is

Analyzing the vegetation response under different treatments after wildfires in NE Spain

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León, Javier; Cerdà, Artemi; Badía, David; Echeverría, Maite; Martí, Clara

2014-05-01

effects of ash type, thickness and rainfall events. Geoderma 209-210, 143-152. Mataix-Solera, J., Cerdà, A., Arcenegui, V., Jordán, A., Zavala, L.M., 2011. Fire effects on soil aggregation: a review. Earth-Science Reviews, 109: 44-60. Neary, D.G., Klopatek, C.C., DeBano, L.F., Ffolliot, P. 1999. Fire effects on belowground sustainability: a review and synthesis. Forest Ccol. Manag., 122: 51-71. Pereira, P., Cerdà, A., Úbeda, X., Mataix-Solera, J., Martin, D., Jordán, A., Burguet, M. 2013. Spatial models for monitoring the spatio-temporal evolution of ashes after fire - a case study of a burnt grassland in Lithuania. Solid Earth, 4: 153-165. Prats, S.A., Malvar, M.C., Simões-Vieira, D.C., MacDonald, L., and Keizer, J.J. 2013. Effectiveness of hydromulching to reduce runoff and erosion in a recently burnt pine plantation in central Portugal. Land Degradation & Development, DOI: 10.1002/ldr.2236. Shakesby, R.A. 2011. Post-wildfire soil erosion in the Mediterranean: Review and future research directions. Earth Science Reviews, 105, 71-100.

Effectiveness of two contrasting mulching rates to reduce post-fire soil and organic matter losses

Science.gov (United States)

Silva, Flavio; Prats, Sergio; Vieira, Diana; Puga, João; Lopes, Rita; Gonzaléz-Pelayo, Oscar; Caetano, Ana; Campos, Isabel; Keizer, Jacob

2017-04-01

-639 Ferreira R.V., Serpa D., Machadoa A.I., Rodríguez-Blanco M.L., Santos L.F., Taboada-Castro M.T., Cerqueira M.A., Keizer J.J., 2016. Short-term nitrogen losses by overland flow in a recently burnt forest area in north-central Portugal: a study at micro-plot scale. Science of the Total Environment 572: 1281-1288. Prats, S.A., MacDonald, L.H., Monteiro, M., Ferreira, A.J.D., Coelho, C.O.A., Keizer, J.J., 2012. Effectiveness of forest residue mulching in reducing post-fire runoff and erosion in a pine and a eucalypt plantation in north-central Portugal. Geoderma 191: 115-124. Prats, S.A., Malvar, M.C., Martins, M.A.S., Keizer, J.J., 2014. Post-fire soil erosion risk assessment and mitigation: new approaches for reducing runoff and soil erosion in Portugal. Cuardernos de Investigatión Geográfica 40: 403-427. Prats SA., Wagenbrenner J., Malvar MC., Martins MAS., Keizer JJ., 2016 Mid-term effectiveness of mulching-based treatments in central Portugal. Science of the Total Environment 573: 1242-1254 Prats S.A., Wagenbrenner J.W., Martins M.A.S., Malvar M.C., Keizer J.J., 2016 Hydrological implications of post-fire mulching across different spatial scales Land Degradation and Development 27: 1440-1452 Puga J., Abrantes, N., Oliveira M.J.S., Vieira, D.C.S., Faria., S.R., Gonçalves F., Keizer J.J., 2016. Long-Term Impacts of Post-Fire Mulching on Ground-Dwelling Arthropod Communities in a Eucalypt Plantation. Land Degradation and Development, in press. DOI: 10.1002/ldr.2583 Verheijen, F.G.A., Jones, R.J.A., Rickson, R.J., Smith, C.J., 2009. Tolerable versus actual soil erosion rates in Europe. Earth Science. Reviews. 94: 23-38.

Proceedings of the 8th International Symposium on Foundations of Quantum Mechanics in the Light of New Technology

Science.gov (United States)

Ishioka, Sachio; Fujikawa, Kazuo

2006-06-01

-Horne-Zeilinger states in Josephson systems / T. Fujii, M. Nishida, N. Hatakenaka -- Quantum-dot systems. Tunable tunnel and exchange couplings in double quantum dots / S. Tarucha, T. Hatano, M. Stopa. Coherent transport through quantum dots / S. Katsumoto ... [et al.]. Electrically pumped single-photon sources towards 1.3 [symbol]m / X. Xu ... [et al.]. Aharonov-Bohm-type effects in antidot arrays and their decoherence / M. Kato ... [et al.]. Nonequilibrium Kondo dot connected to ferromagnetic leads / Y. Utsumi ... [et al.]. Full counting-statistics in a single-electron transistor in the presence of strong quantum fluctuations / Y. Utsumi -- Anomalous Hall effect and Spin-Hall effect. Geometry and the anomalous Hall effect in ferromagnets / N. P. Ong, W.-L. Lee. Control of spin chirality, Berry phase, and anomalous Hall effect / Y. Tokura, Y. Taguchi. Quantum geometry and Hall effect in ferromagnets and semiconductors / N. Nagaosa. Spin-Hall effect in a semiconductor two-dimensional hole gas with strong spin-orbit coupling / J. Wunderlich ... [et al.]. Intrinsic spin Hall effect in semiconductors / S. Murakami -- Spin related phenomena. Theory of spin transfer phenomena in magnetic metals and semiconductors / A. S. Núñez, A. H. MacDonald. Spin filters of semiconductor nanostructures / T. Dietl, G. Grabecki, J. Wróbel. Experimental study on current-driven domain wall motion / T. Ono ... [et al.]. Magnetization reversal of ferromagnetic nano-dot by non local spin injection / Y. Otani, T. Kimura. Theory of current-driven domain wall dynamics / G. Tatara ... [et al.]. Magnetic impurity states and ferromagnetic interaction in diluted magnetic semiconductors / M. Ichimura ... [et al.]. Geometrical effect on spin current in magnetic nano-structures / M. Ichimura, S. Takahashi, S. Maekawa. Ferromagnetism in anatase TiO[symbol] codoped with Co and Nb / T. Hitosugi ... [et al.] -- Superconductivity in nano-systems. Nonlinear quantum effects in nanosuperconductors / C. Carballeira ... [et al

The peculiar case of Marosticano xenoliths: a cratonic mantle fragment affected by carbonatite metasomatism in the Veneto Volcanic Province (Northern Italy)

Science.gov (United States)

Brombin, Valentina; Bonadiman, Costanza; Coltorti, Massimo; Florencia Fahnestock, M.; Bryce, Julia G.; Marzoli, Andrea

2017-04-01

Province, Southern Alps. Geological Society of America, 131-152. Beccaluva L., Bonadiman C., Coltorti M., Salvini L., Siena F. (2001). Depletion events, nature of metasomatizing agent and timing of enrichment processes in lithospheric mantle xenoliths from the Veneto Volcanic Province. Journal of Petrology, 42, 173-187. Coltorti, M., Bonadiman, C., Hinton, R.W., Siena, F., Upton, B.G.J. (1999). Carbonatite metasomatism of the oceanic upper mantle: evidence from clinopyroxenes and glasses in ultramafic xenoliths of Grande Comore, Indian Ocean. Journal of Petrology, 40, 133-165. Downes, H., MacDonald, R., Upton, B.G.J., Cox, K.G, Bodinier, J-L, Mason, P.R.D, James, D., Hill, P.G., Hearn, C. Jr (2004). Ultramafic xenoliths from the Bearpaw Mountains, Montana, USA: evidence for multiple metasomatic events in the lithospheric mantle beneath the Wyoming Carton. Journal of Petrology, 45, 1631-1662. Foley, S.F. (2011). A reappraisal of redox melting in the Earth's mantle as a function of tectonic setting and time. Journal of Petrology, 52, 1363-1391. Gasperini D., Bosch D., Braga R., Bondi M., Macera P., Morten L. (2006). Ultramafic xenoliths from the Veneto Volcanic Province (Italy): Petrological and geochemical evidence for multiple metasomatism of the SE Alps mantle lithospere. Geochemical Journal, 40, 377-404. Kelemen, P.B., Hart, S.R., Bernstein, S. (1998). Silica enrichment in the continental upper mantle via melt/rock reaction. Earth and Planetary Science Letters, 164, 387-406. Ramsey, R.R, Tompkins, L.A. (1994). The geology, heavy mineral concentrate mineralogy, and diamond prospectivity of the Boa Esperança and Cana Verde pipes, Corrego D'anta, Minas Gerais, Brazil, in: Meyer, H.O.A and Leonardos, O.H. (Eds.), Proceeding of the Fifth International Kimberlite Conference 2. Companhia de Pesquisa de Recursors Minerais, Special Publications, 329-345. Siena F., Coltorti M. (1989). Lithospheric mantle evolution: evidences from ultramafic xenoliths in the Lessinean volcanics

PREFACE: International Conference on Magnetism (ICM 2009)

Science.gov (United States)

Goll, Gernot; Löhneysen, Hilbert v.; Loidl, Alois; Pruschke, Thomas; Richter, Manuel; Schultz, Ludwig; Sürgers, Christoph; Wosnitza, Jochen

2010-11-01

helped to run the conference. We are grateful for financial support to Universität Karlsruhe (TH) and Forschungszentrum Karlsruhe (both institutions merged to form the Karlsruhe Institute of Technology (KIT) as of 1 October 2009), International Union of Pure and Applied Physics (IUPAP), the City of Karlsruhe, Deutsche Forschungsgemeinschaft (German National Science Foundation) and the European Commission through COST MPNS Action P16. Hilbert v Löhneysen Karlsruhe Institute of Technology Email address: hilbert.loehneysen@kit.edu Logo Conference Organization Chairperson Hilbert v Löhneysen, Karlsruhe Members of IUPAP Commission 9 Magnetism C Chang, TaipeiD Kaczorowski, Wroclaw khrouhou, SfaxP H Kes, Leiden M A Continentino, NiteróiS Maekawa, Sendai D E Dahlberg, MinnesotaI Mertig, Halle D Fiorani, RomaD McMorow, London M R Freeman, EdmontonS Rezende, Recife D Givord, GrenobleS Sanvito, Dublin A Granovsky, MoscowJ Xiaofeng, Shanghai International Advisory Board G Aeppli, UKM Gingras, Canada I Affleck, CanadaJ C Gomez Sal, Spain J Akimitsu, JapanP A Grünberg, Germany D Awschalom, USAB Heinrich, Canada S D Bader, USAT J Hicks, Australia E Baggio-Saitovitch, BrazilM R Ibarra, Spain M N Baibich, BrazilY H Jeong, Korea G Baskaran, IndiaB Keimer, Germany E Bauer, AustriaG Kotliar, USA R J Birgeneau, USAR B Laughlin, USA P Bruno, GermanyP A Lee, USA J Chapman, UKG G Lonzarich, UK Y Endoh, JapanA MacDonald, USA A Fert, FranceM B Maple, USA J Fink, GermanyA J Millis, USA Z Fisk, USAL W Molenkamp, Germany J Flouquet, FranceJ A Mydosh, Germany A J Freeman, USAY Maeno, Japan H Fukuyama, JapanK Miyake, Japan P Fulde, GermanyP Nordblad, Sweden H Ohno, JapanF Steglich, Germany H R Ott, SwitzerlandT Takabatake, Japan Y Onuki, JapanJ L Tholence, France S S P Parkin, USAY Tokura, Japan A P Ramirez, USAK Ueda, Japan T M Rice, SwitzerlandD Vollhardt, Germany Z X Shen, USAE F Wassermann, Germany S -C Shin, KoreaM K Wu, Taiwan T Shinjo, JapanD Y Xing, China J C Slonczewski, USAY D Yao

EDITORIAL: Announcing the 2005 Measurement Science and Technology Outstanding Paper Awards

Science.gov (United States)

Foss, John; Dewhurst, Richard; Fujii, Kenichi; Regtien, Paul

2006-06-01

displacements are grouped around integer pixel values. Background subtraction can help reduce the tendency for peak locking, but does not completely remove the bias. Other techniques for eliminating the bias are available, but require time-consuming, iterative processing. The paper of Chen and Katz describes a processing technique that removes this 'peak locking' bias by avoiding the curve fitting process altogether. Instead, the displacement necessary to map the first exposure into the second exposure is determined via a correlation mapping operation. Several example cases using synthetic data and actual PIV data are presented. The new approach is also compatible with the Subregion Image Distortion technique to further improve the quality of the PIV displacement estimates. 2005 Award Winners—Measurement Science The 2005 Measurement Science and Technology Outstanding Paper Award in the Measurement Science category has been awarded to M E Webber, T MacDonald, M B Pushkarsky (Pranalytica, Inc., USA), C K N Patel (UCLA, USA), Y Zhao, N Marcillac and F M Mitloehner (University of California, Davis, USA) for the article 'Agricultural ammonia sensor using diode lasers and photoacoustic spectroscopy', published in volume 16, issue 8, pp 1547 1553. In making their recommendation the Measurement Science working group chaired by Professor Richard Dewhurst gave the following endorsement: This paper provides an excellent description of a novel instrumentation system used to detect agricultural ammonia. The sensor system has been designed for use in dusty and humid conditions, and a portable prototype was field-tested on several days over an eight-week period, with encouraging results. In this paper, a short theoretical section is followed by instrumentation details, with a description of the optical system, the electronics, embedded programming and algorithm development. An erbium-doped fibre amplifier was used to enhance the photoacoustic signal by boosting the laser's output power

Book Reviews

Directory of Open Access Journals (Sweden)

Redactie KITLV

1995-07-01

: University of Tennessee Press, 1992. xx + 254 pp. -O. Nigel Bolland, Michael Havinden ,Colonialism and development: Britain and its tropical colonies, 1850-1960. New York: Routledge, 1993. xv + 420 pp., David Meredith (eds -Luis Martínez-Fernández, Luis Navarro García, La independencia de Cuba. Madrid: MAPFRE, 1992. 413 pp. -Pedro A. Pequeño, Guillermo J. Grenier ,Miami now! : Immigration, ethnicity, and social change. Gainesville: University Press of Florida, 1992. 219 pp., Alex Stepick III (eds -George Irving, Alistair Hennessy ,The fractured blockade: West European-Cuban relations during the revolution. London: Macmillan Caribbean, 1993. xv + 358 pp., George Lambie (eds -George Irving, Donna Rich Kaplowitz, Cuba's ties to a changing world. Boulder CO: Lynne Rienner, 1993, xii + 263 pp. -G.B. Hagelberg, Scott B. MacDonald ,The politics of the Caribbean basin sugar trade. New York: Praeger, 1991. vii + 164 pp., Georges A. Fauriol (eds -Bonham C. Richardson, Trevor W. Purcell, Banana Fallout: Class, color, and culture among West Indians in Costa Rica. Los Angeles: UCLA Center for Afro-American studies, 1993. xxi + 198 pp. -Gertrude Fraser, George Gmelch, Double Passage: The lives of Caribbean migrants abroad and back home. Ann Arbor: University of Michigan Press, 1992. viii + 335 pp. -Gertrude Fraser, John Western, A passage to England: Barbadian Londoners speak of home. Minneapolis: University of Minnesota Press, 1992. xxii + 309 pp. -Trevor W. Purcell, Harry G. Lefever, Turtle Bogue: Afro-Caribbean life and culture in a Costa Rican Village. Cranbury NJ: Susquehanna University Press, 1992. 249 pp. -Elizabeth Fortenberry, Virginia Heyer Young, Becoming West Indian: Culture, self, and nation in St. Vincent. Washington DC: Smithsonian Institution Press, 1993. x + 229 pp. -Horace Campbell, Dudley J. Thompson ,From Kingston to Kenya: The making of a Pan-Africanist lawyer. Dover MA: The Majority Press, 1993. xii + 144 pp., Margaret Cezair Thompson (eds -Kumar Mahabir, Samaroo

Fire as a natural and human factor shaping the Mediterranean Ecosystems. The Montgó forest fire and the teaching for the Geograns (older than 55) students

Science.gov (United States)

Cerdà, Artemi; González Pelayo, Óscar; Mataix-Solera, Jorge; Arcenegui, Victoria; Jordán, Antonio; Úbeda, Xavier; Pereira, Paulo

2015-04-01

., Zavala, L. M. 2015. Modelling the impacts of wildfire on ash in a short-term period. Land Degradation & Development.| DOI: 10.1002/ldr.2195 Pérez-Cabello, F., Cerdà, A., de la Riva, J., Echeverría, M.T., García-Martín, A., Ibarra, P., Lasanta, T., Montorio, R., Palacios, V. 2012. Micro-scale post-fire surface cover changes monitored using high spatial resolution photography in a semiarid environment: A useful tool in the study of post-fire soil erosion processes, Journal of Arid Environments, 76: 88-96. 10.1016/j.jaridenv.2011.08.007 Pérez-Cabello, F., Cerdà, A., de la Riva, J., Echeverría, M.T., García-Martín, A., Ibarra, P., Lasanta, T., Montorio, R., Palacios, V. 2012. Micro-scale post-fire surface cover changes monitored using high spatial resolution photography in a semiarid environment: A useful tool in the study of post-fire soil erosion processes, Journal of Arid Environments, 76: 88-96. 10.1016/j.jaridenv.2011.08.007 Prats, S.A., Malvar, M.C., Simões-Vieira, D.C., MacDonald, L., Keizer, J.J. 2015. Effectiveness of hydro- mulching to reduce runoff and erosion in a recently burnt pine plantation in central Portugal. Land Degradation & Development, DOI: 10.1002/ldr.2236. Roebroeks, W., Villa, P. 2011. On the earliest evidence for habitual use of fire in Europe. Proceedings of the National Academy of Sciences, 108(13), 5209-5214. Romme, W. H., Boyce, M. S., Gresswell, R., Merrill, E. H., Minshall, G. W., Whitlock, C., Turner, M. G. 2011. Twenty years after the 1988 Yellowstone fires: lessons about disturbance and ecosystems. Ecosystems, 14(7), 1196-1215. Zumbrunnen, T., Menéndez, P., Bugmann, H., Conedera, M., Gimmi, U., Bürgi, M. 2012. Human impacts on fire occurrence: a case study of hundred years of forest fires in a dry alpine valley in Switzerland. Regional Environmental Change, 12(4), 935-949.

Reconocimiento alogénico: su papel protector durante la infección por el virus de la inmunodeficiencia humana tipo1 (VIH-1

Directory of Open Access Journals (Sweden)

María Teresa Rugeles López

2004-03-01

terapia antirretroviral.

REFERENCIAS

1. LEHNER T, SHEARER GM, HACKETT CJ, SCHULTZ A and SHARMA OK. Alloimmunization as a strategy for vaccine design against HIV/AIDS. AIDS Res Hum Retroviruses 2000; 16: 309-313

2. MACDONALD KS, EMBREE J, NJENGA S, NAGELKERKE NJ, NGATIA I, MO- HAMMED Z, et al. Mother-child class I HLA concordance increases perinatal human immunodeficiency virus type 1 transmission. J Infect Dis 1998; 177: 551-556.

3. The International Perinatal HIV Group. The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1 – a meta-analysis of 15 prospective cohort studies. New Engl.J. Med. 1999; 340: 977–987

4. CLERICI M. Cell-mediated immunity in HIV infection. AIDS 1993; 7 (Suppl 1: S135–S140

5. PATTERSON BK, BEHBAHANI H, KABAT W, SULLIVAN Y, O’GORMAN MR, LANDAY A, et al. Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women. J. Clin. Invest. 2001; 107: 287–294

6. BOURINBAIAR AS and LEE-HUANG S. Anti-HIV effect of b subunit of human chorionic gonadotropin (b hCG in vitro. Immunol. Lett. 1995; 44: 13–18

7. COULOMB-L’HERMIN A, AMARA A, SCHIFF C, BURANDGASSELIN I, FOUSSAT A, DELAUNEY T, et al. Stromal cellderived factor 1 (SDF-1 and antenatal human B cell lymphopoiesis: expression of SDF-1 by

Ash wettability conditions splash erosion in the postfire

Science.gov (United States)

Gordillo-Rivero, Ángel J.; de Celis, Reyes; García-Moreno, Jorge; Jiménez-Compán, Elizabeth; Alanís, Nancy; Cerdà, Artemi; Pereira, Paulo; Zavala, Lorena M.; Jordán, Antonio

2015-04-01

mobilization of sediments at plot scale. Further research should focus on the impacts of ash wettability on splash erosion at hillslope scale in the post fire. REFERENCES Bodí MB, Doerr SH, Cerdà A, Mataix-Solera J. 2012. Hydrological effects of a layer of vegetation ash on underlying wettable and water repellent soil. Geoderma 191, 14-23. Bodí MB, Martin DA, Balfour VN, Santín C, Doerr SJ, Pereira P, Cerdà A. Mataix-Solera J. 2014. Wildland fire ash: Production, composition and eco-hydro-geomorphic effects. Earth-Sciece Reviews 130, 103-127. Cerdà A, Doerr, SH. 2008. The effect of ash and needle cover on surface runoff and erosion in the immediate post-fire period. Catena 74, 256-263. De Celis R, Jordán A, Zavala LM. 2013. Efectos del fuego en las propiedades biológicas, físicas y químicas del suelo. In: Bento-Gonçalves A, Vieira A (Eds.), Grandes incêndios florestais, erosão, degradação e medidas de recuperação dos solos. Núcleo de Investigação en Geografia e Planeamento (NIGP), Universidade do Minho. Guimaraes. Pp.: 145-160. DeBano LF. 1991. The effect of fire on soil. In: Harvey AE; Neuenschwander LF.(Eds.), Management and productivity of western-montane forest soils. General Technical Report INT-280. Intermountain Forest and Range Experimental Station, United States Department of Agriculture, Forest Service. Ogden, UT. DeBano LF. 2000. Water repellency in soils: a historical overview. Journal of Hydrology 231-232, 4-32. Doerr SH, Shakesby RA, Walsh RPD. 2000. Soil water repellency: its causes, characteristics and hydro-geomorphological significance. Earth-Science Reviews 51, 33-65. Larsen I, MacDonald LH, Brown E, Rough D, Welsh MJ, Pietraszek JH, Libohava Z, Benavides-Solorio JD, Schaffrath K. 2009. Causes of post-fire runoff and erosion: water repellency, cover or soil heating?. Soil Science Society of America Journal 73, 1393-1407. Mataix-Solera J, Guerrero C. 2007. Efecto de los incendios forestales sobre las propiedades edáficas. In: J. Mataix

forth in Book II of the Confessions. For him, sinning does not consist in seeking things that are completely wrong or bad. Rather, it consists in seeking things that, even if good, distract the attention of a person from the source of all goodness, which is God. Sinning, or committing any evil action, can therefore be characterized as acting out of love in an inappropriate way (e.g. loving a created good instead of God). By loving a created good instead of God, one claims for oneself the power—which one does not have and could never have, for only God can do this—of deciding the value of things, whatever their true value may be. In this sense it can be said that any evil action is, for Augustine, a perverse imitation of God. Scott MacDonald elaborates on this idea. According to him, sinning represents a form of self-assertion, a lack of humility or pride which can be found in the base of every sin. (MacDonald 2006, pp. 62) Returning to self-deception, we can now focus on the parallelism between Augustine's treatment of this phenomenon and his account of sin. Self-deception can be characterized as believing in an inappropriate way (i.e. choosing to believe what is false when one has the opportunity of believing what is true). By choosing to believe what is false in this way, one claims for oneself the power—which one does not have and could never have—of deciding the truth or falsity of beliefs, regardless of their objective truth value. In this sense it can be said that self-deception is a perverse imitation of truth. And this also represents a kind of self-assertion or pride, since what motivates the self-deception is the already mentioned fact that "men hate the truth when it proves them wrong". As is easily noted, the similarities between these explanations are many, and given that, according to Augustine's account of sin, when a man sins he goes against what he really believes (for men are able to realize that it is God and not them who determines the

OpenAIRE

Roberto Parra Dorantes

2017-01-01

The main objective of this paper is to argue that Augustine’s analysis of the concept of memory in Confessions, Book X, would greatly benefit from the hierarchical argumentative and explanatory schema he himself employs in other works to discuss the relation between the senses, the inner sense, and reason in perception. A brief overview of Augustine’s account of memory in the Confessions is presented, followed by a discussion of two argumentative and explanatory schemata Augustine often emplo...