Sample records for m7 moustakas alanyali

  1. Clark E. Moustakas (1923-2012). (United States)

    Blau, Diane S


    Presents an obituary for Clark E. Moustakas. Clark E. Moustakas was a consummate educator and a true model of the tenets and values of humanistic psychology, a movement he cofounded in the late 1950s with other pioneers in American psychology, including Abraham Maslow and Carl Rogers. This movement, recognized as the "third force" in psychology, had a significant impact in the 1960s and 1970s and became an important component of mainstream practice. Moustakas produced a prolific and influential body of work. He embraced solitude as a time of reflection and did not enjoy notoriety. While he inhabited many roles-professor, scholar, clinician, and author-engagement with others in the moment was always the most essential element in his life. He was a gentle man, full of energy and spirit, exuding warmth and focused attention. In his company, one was immediately struck by his earnestness and caring. People from all over the world respected his expertise and sought his advice. To have this impact and to have informed the field in so many ways is a remarkable accomplishment.

  2. 77 FR 54787 - Airworthiness Directives; M7 Aerospace LLC Airplanes (United States)


    ... Airworthiness Directives; M7 Aerospace LLC Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... Aerospace LLC Models SA226-AT, SA226-T, SA226-T(B), SA226-TC, SA227-AC (C-26A), SA227-BC (C-26A), SA227-CC..., contact M7 Aerospace LP, 10823 NE Entrance Road, San Antonio, Texas 78216; phone: (210) 824- 9421; fax...

  3. Stress triggering of the Lushan M7. 0 earthquake by the Wenchuan Ms8. 0 earthquake

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    Wu Jianchao


    Full Text Available The Wenchuan Ms8. 0 earthquake and the Lushan M7. 0 earthquake occurred in the north and south segments of the Longmenshan nappe tectonic belt, respectively. Based on the focal mechanism and finite fault model of the Wenchuan Ms8. 0 earthquake, we calculated the coulomb failure stress change. The inverted coulomb stress changes based on the Nishimura and Chenji models both show that the Lushan M7. 0 earthquake occurred in the increased area of coulomb failure stress induced by the Wenchuan Ms8. 0 earthquake. The coulomb failure stress increased by approximately 0. 135 – 0. 152 bar in the source of the Lushan M7. 0 earthquake, which is far more than the stress triggering threshold. Therefore, the Lushan M7. 0 earthquake was most likely triggered by the coulomb failure stress change.

  4. Transient poroelastic stress coupling between the 2015 M7.8 Gorkha, Nepal earthquake and its M7.3 aftershock (United States)

    Tung, S.; Masterlark, T.; Dovovan, T.


    The large M7.3 aftershock occurred 17 days after the 2015 M7.8 Gorkha earthquake. We investigate if this sequence is mechanically favored by the mainshock via time-dependent fluid migration and pore pressure recovery. This study uses finite element models of fully-coupled poroelastic coseismic and postseismic behavior to simulate the evolving stress and pore-pressure fields. Using simulations of a reasonable permeability, the hypocenter was destabilized by an additional 0.15 MPa of Coulomb failure stress change (ΔCFS) and 0.17 MPa of pore pressure (Δp), the latter of which induced lateral and upward diffusive fluid flow (up to 2.76 mm/day) in the aftershock region. The M7.3 location is predicted next to a local maximum of Δp and a zone of positive ΔCFS northeast of Kathmandu. About 60% of the aftershocks occurred within zones having either Δp > 0 or ΔCFS > 0. Particularly in the eastern flank of the epicentral area, 83% of the aftershocks experienced postseismic fluid pressurization and 88% of them broke out with positive pore pressure, which are discernibly more than those with positive ΔCFS (71%). The transient scalar field of fluid pressurization provides a good proxy to predict aftershock-prone areas in space and time, because it does not require extraction of an assumed vector field from transient stress tensor fields as is the case for ΔCFS calculations. A bulk permeability of 8.32 × 10-18 m2 is resolved to match the transient response and the timing of the M7.3 rupture which occurred at the peak of the ΔCFS time-series. This estimate is consistent with the existing power-law permeability-versus-depth models, suggesting an intermediately-fractured upper crust coherent with the local geology of the central Himalayas. The contribution of poroelastic triggering is verified against different poroelastic moduli and surface flow-pressure boundaries, suggesting that a poroelastic component is essential to account for the time interval separating the

  5. Local Postseismic Relaxation Observed After the 1992 Landers (M=7.3), 1999 Hector Mine (M=7.1), 2002 Denali (M=7.9), and 2003 San Simeon (M=6.5) Earthquakes (United States)

    Svarc, J. L.; Savage, J. C.


    The U. S. Geological Survey has observed the local postseismic deformation following the 1992 Landers (M=7.3), 1999 Hector Mine (M=7.1), 2002 Denali (M=7.9), and 2003 San Simeon (M=6.5) earthquakes. The observations consist of repeated campaign-style GPS surveys of geodetic arrays (aperture ˜ 50 km) in the epicentral area of each earthquake. The data span the intervals from 0.037 to 5.6, 0.0025 to 4.5, 0.022 to 1.6, and 0.005 to 0.55 yr postearthquake for the Landers, Hector Mine, Denali, and San Simeon earthquakes, respectively. We have reduced the observations to positions of the monuments measured relative to another monument within the array. The temporal dependence of the relative displacements for each monument can be approximated by a+bt+c(1-exp[-t/d]) where a, b, c, and d are constants particular to that monument and t is the time after the earthquake. The relaxation times d were found to be 0.367±0.062, 0.274±0.024, 0.145±0.017, and 0.032±0.002 yr for the Landers, Hector Mine, Denali, and San Simeon earthquakes, respectively. The observed increase in d with the duration of the time series fit suggests that the relaxation process involves more than a single relaxation time. An alternative function a'+b't+c'log(1+t/d') where a', b', c', and d' are constants particular to each monument furnishes a better fit to the data. This logarithmic form of the relaxation (Lomnitz creep function), identical to the calculated response of a simple spring-slider system subject to rate-state friction [Marone et al., 1991], contains a continuous spectrum of relaxation times. In fitting data the time constant d' is determined by observations within the first few days postseismic and consequently is poorly defined. Adequate fits to the data are found by simply setting d'=0.001 yr and determining a', b', and c' by linear least squares. That the temporal dependence is so readily fit by both exponential and logarithmic functions suggests that the temporal dependence by itself

  6. Transient Effects in Atmosphere and Ionosphere preceding the two 2015 M7.8 and M7.3 Earthquakes in Nepal (United States)

    Ouzounov, D.; Pulinets, S. A.; Hernandez-Pajares, M.; Alberto Garcia Rigo, A. G.; Davidenko, D.; Hatzopoulos, N.; Kafatos, M.


    The recent M7.8 Nepal earthquake of April 25, 2015 was the largest recorded earthquake event to hit this nation since 1934. We prospectively and retrospectively analyzed the transient variations of three different physical parameters - outgoing earth radiation (OLR), GPS/TEC and the thermodynamic proprieties in the lower atmosphere. These changes characterize the state of the atmosphere and ionosphere several days before the onset of this earthquake. Our preliminary results show that in mid March 2015 a rapid increase of emitted infrared radiation was observed from the satellite data and an anomaly near the epicenter reached the maximum on April 21-22. The ongoing analysis of satellite radiation revealed another transient anomaly on May 3th, probably associated with the M7.3 of May 12, 2015. The analysis of air temperature form ground stations show similar patterns of rapid increases offset 1-2 days earlier to the satellite transient anomalies.The GPS/TEC data indicate an increase and variation in electron density reaching a maximum value during April 22-24. We found a strong negative TEC anomaly in the crest of EIA (Equatorial Ionospheric Anomaly) on April 21st and strong positive on April 24th, 2015. Our results show strong ionospheric effects not only in the changes of the EIA intensity but also within the latitudinal movements of the crests of EIA.

  7. Comparison of childhood myelodysplastic syndrome, AML FAB M6 or M7, CCG 2891: report from the Children's Oncology Group. (United States)

    Barnard, Dorothy R; Alonzo, Todd A; Gerbing, Robert B; Lange, Beverly; Woods, William G


    Myelodysplastic syndromes (MDS), acute erythroleukemia (FAB M6), and acute megakaryocytic leukemia (FAB M7) have overlapping features. Children without Down syndrome or acute promyelocytic leukemia who were newly diagnosed with primary myelodysplastic syndrome or acute myeloid leukemia (AML) M6 or M7 were compared to children with de novo AML M0-M5. All children were entered on the Children's Cancer Group therapeutic research study CCG 2891. The presentation and outcomes of the 132 children diagnosed with MDS (60 children), AML FAB M6 (19 children), or AML FAB M7 (53 children) were similar. Children with AML FAB M7 were diagnosed at a significantly younger age (P = 0.001). Children with MDS, M6, or M7 had significantly lower white blood cell (WBC) counts (P = 0.001), lower peripheral blast counts (P M6 and AML M7 resemble MDS in presentation, poor induction success rates, and outcomes.

  8. Long-Delayed Aftershocks in New Zealand and the 2016 M7.8 Kaikoura Earthquake (United States)

    Shebalin, P.; Baranov, S.


    We study aftershock sequences of six major earthquakes in New Zealand, including the 2016 M7.8 Kaikaoura and 2016 M7.1 North Island earthquakes. For Kaikaoura earthquake, we assess the expected number of long-delayed large aftershocks of M5+ and M5.5+ in two periods, 0.5 and 3 years after the main shocks, using 75 days of available data. We compare results with obtained for other sequences using same 75-days period. We estimate the errors by considering a set of magnitude thresholds and corresponding periods of data completeness and consistency. To avoid overestimation of the expected rates of large aftershocks, we presume a break of slope of the magnitude-frequency relation in the aftershock sequences, and compare two models, with and without the break of slope. Comparing estimations to the actual number of long-delayed large aftershocks, we observe, in general, a significant underestimation of their expected number. We can suppose that the long-delayed aftershocks may reflect larger-scale processes, including interaction of faults, that complement an isolated relaxation process. In the spirit of this hypothesis, we search for symptoms of the capacity of the aftershock zone to generate large events months after the major earthquake. We adapt an algorithm EAST, studying statistics of early aftershocks, to the case of secondary aftershocks within aftershock sequences of major earthquakes. In retrospective application to the considered cases, the algorithm demonstrates an ability to detect in advance long-delayed aftershocks both in time and space domains. Application of the EAST algorithm to the 2016 M7.8 Kaikoura earthquake zone indicates that the most likely area for a delayed aftershock of M5.5+ or M6+ is at the northern end of the zone in Cook Strait.

  9. Biological and Histological Studies of Purified Product from Streptomyces janthinus M7 Metabolites

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    Tawfik Zahira S.


    Full Text Available Fifteen clinical samples were taken out from patients suffering cancer, these patients being under the treatment with radio- and/or chemotherapy. The samples were used for the isolation of bacterial cells surrounding tumor; the samples were collected from Center of Cancer Therapy, Ain Shams University, Cairo, Egypt. The clinical bacterial isolates were purified and identified according to Bergey's manual of determinative bacteriology ninth edition (1994. The bacterial isolates were found to be Klebsiella oxytoca m1; Enterobacter cancerogenus m2; P. aeruginosa m3; Citrobacter diversus m4; Enterobacter agglomerans m5; Klebsiella oxytoca m6; Enterobacter dissolvens m7; Serratia fonticola m8; Escherichia coli m9; Citrobacter freundii m10; Staphylococcus aureus m11; Escherichia coli m12; P. aeruginosa m13; Staphylococcus aureus m14; and Bacillus cereus m15. In the present study both primary and secondary screening methods were used to screen the antibacterial activity of St. janthinus M7 against fifteen clinical bacterial isolates. The St. janthinus M7 showed an increase in antibacterial activity against all the tested human bacterial pathogens. In this study Gamma irradiation at dose levels (0.5 and 1.5 kGy was used for the enhancement of the antibacterial activity of Streptomyces strain against the clinical isolates. Several commercial antibiotic discs (Doxorubicin, Augmentin, Norfloxacin, Ofloxacin, Oxacillin, and Cefazolin were used for comparing their antimicrobial activity with purified product. The results declared a significant increase in the antibacterial activity in most cases. The physiochemical properties of the purified product were carried out for determination of Rf, empirical formula, M.W, and chemical structure of product and then analyzed by thin layer chromatography, elemental analysis, UV, Mass, and NMR. The result exhibited brown color, one spot, Rf (0.76, M.W (473, while it recorded 270 nm in UV region and the calculated

  10. The carbide M7C3 in low-temperature-carburized austenitic stainless steel

    International Nuclear Information System (INIS)

    Ernst, Frank; Li, Dingqiang; Kahn, Harold; Michal, Gary M.; Heuer, Arthur H.


    Prolonged low-temperature gas-phase carburization of AISI 316L-type austenitic stainless steel can cause intragranular precipitation of the carbide M 7 C 3 (M: randomly dispersed Fe, Cr, Ni). Transmission electron microscopy revealed that the carbide particles have the shape of needles. They grow by a ledge-migration mechanism and in a crystallographic orientation relationship to the austenite matrix that enables highly coherent interphase interfaces. A small solubility limit of Ni in the carbide and restricted Ni diffusivity at the processing temperature leads to Ni pileup around the particles and may explain the extreme aspect ratio of the particle shape. These characteristics closely resemble what has been observed earlier for precipitates of M 5 C 2 under slightly different processing conditions and can be rationalized by considering the particular constraints imposed by carburization at low temperature.

  11. Building M7-0505 Treatment Tank (SWMU 039) Annual Performance Monitoring Report (United States)


    This Annual Performance Monitoring Report presents a summary of Interim Measure (IM) activities and an evaluation of data collected during the third year (June 2014 to September 2015) of operation, maintenance, and monitoring (OM&M) conducted at the Building M7-505 (M505) Treatment Tank area, Kennedy Space Center (KSC), Florida ("the Site"). Under KSC's Resource Conservation and Recovery Act Corrective Action Program, the M505 Treatment Tank area was designated Solid Waste Management Unit 039. Arcadis U.S., Inc. (Arcadis) began IM activities on January 10, 2012, after completion of construction of an in situ air sparge (IAS) system to remediate volatile organic compounds (VOCs) in groundwater at concentrations exceeding applicable Florida Department of Environmental Protection (FDEP) Chapter 62-777, Florida Administrative Code, Natural Attenuation Default Concentrations (NADCs). This report presents a summary of the third year of OM&M activities conducted between June 2014 and September 2015.

  12. What role did the Hikurangi subduction zone play in the M7.8 Kaikoura earthquake? (United States)

    Wallace, L. M.; Hamling, I. J.; Kaneko, Y.; Fry, B.; Clark, K.; Bannister, S. C.; Ellis, S. M.; Francois-Holden, C.; Hreinsdottir, S.; Mueller, C.


    The 2016 M7.8 Kaikoura earthquake ruptured at least a dozen faults in the northern South Island of New Zealand, within the transition from the Hikurangi subduction zone (in the North Island) to the transpressive Alpine Fault (in the central South Island). The role that the southern end of the Hikurangi subduction zone played (or did not play) in the Kaikoura earthquake remains one of the most controversial aspects of this spectacularly complex earthquake. Investigations using near-field seismological and geodetic data suggest a dominantly crustal faulting source for the event, while studies relying on teleseismic data propose that a large portion of the moment release is due to rupture of the Hikurangi subduction interface beneath the northern South Island. InSAR and GPS data also show that a large amount of afterslip (up to 0.5 m) occurred on the subduction interface beneath the crustal faults that ruptured in the M7.8 earthquake, during the months following the earthquake. Modeling of GPS velocities for the 20 year period prior to the earthquake indicate that interseismic coupling was occurring on the Hikurangi subduction interface beneath the northern South Island, in a similar location to the suggested coseismic and postseismic slip on the subduction interface. We will integrate geodetic, seismological, tsunami, and geological observations in an attempt to balance the seemingly conflicting views from local and teleseismic data regarding the role that the southern Hikurangi subduction zone played in the earthquake. We will also discuss the broader implications of the observed coseismic and postseismic deformation for understanding the kinematics of the southern termination of the Hikurangi subduction zone, and its role in the transition from subduction to strike-slip in the central New Zealand region.

  13. Inhibition of translation by 7-methyl guanosine (m7G) nucleotide cap analogs with derivatized 5'-monophosphates

    International Nuclear Information System (INIS)

    Tahara, S.M.; Darzynkiewicz, E.; Ekiel, I.


    Recognition of the 5'-m 7 GpppN (cap) structure of eukaryote mRNA is an important step of translation initiation as shown by the potent inhibitory effect of m 7 G nucleotides on this process. A comparison of cap analogs as competitive inhibitors of initiation has allowed the authors to map probable protein-ligand contact points between the cap and cognate cap binding proteins (CBPs). Recently, several new derivatives of m 7 GMP (1) with modified phosphates were synthesized: m 7 G 5'-phosphite (2), m 7 G 5'-phosphoramidate (3), m 7 G 5'-methylphosphonate (4), and m 7 G 5'-phosphate-O-methyl ester (5). In addition, 7,8-dimethyl GMP (6) and 7-methyl 8-amino GMP (7) were synthesized. 6 and7 are primarily syn and anti respectively, relative to the glycosidic bond as shown by solution NMR studies. Inhibition by analogs on total translation in reticulocyte lysate and binding of mRNA to rabbit reticulocyte ribosomes was found to be: 1 = 3 > 5 > 4 > 2. The inhibitory activity of 3 was unexpected since it is isosteric with 4, however it suggested that electron configuration and/or the ability to form a hydrogen bond between protein and the phosphate moiety might be important for ligand binding. 7 was more inhibitory than 6. The latter two are isosteric therefore differences in electron delocalization and/or syn-anti conformation are likely to be the reason(s) for the observed difference

  14. Simulating Marine New Particle Formation and Growth Using the M7 Modal Aerosol Dynamics Modal

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    Ciaran Monahan


    Full Text Available A modal atmospheric aerosol model (M7 is evaluated in terms of predicting marine new particle formation and growth. Simulations were carried out for three different nucleation schemes involving (1 kinetic self-nucleation of OIO (2 nucleation via OIO activation by H2SO4 and (3 nucleation via OIO activation by H2SO4 plus condensation of a low-volatility organic vapour. Peak OIO and H2SO4 vapour concentrations were both limited to 6×106 molecules cm-3 at noontime while the peak organic vapour concentration was limited to 12×106 molecules cm-3. All simulations produced significant concentrations of new particles in the Aitken mode. From a base case particle concentration of 222 cm-3 at radii >15 nm, increases in concentrations to 366 cm-3 were predicted from the OIO-OIO case, 722 cm-3 for the OIO-H2SO4 case, and 1584 cm-3 for the OIO-H2SO4 case with additional condensing organic vapours. The results indicate that open ocean new particle production is feasible for clean conditions; however, new particle production becomes most significant when an additional condensable organic vapour is available to grow the newly formed particles to larger sizes. Comparison to sectional model for a typical case study demonstrated good agreement and the validity of using the modal model.

  15. Tomography of the 2011 Iwaki earthquake (M 7.0) and Fukushima nuclear power plant area

    Energy Technology Data Exchange (ETDEWEB)

    Tong, P. [Tohoku Univ., Sendai (Japan). Dept. of Geophysics; Tsinghua Univ., Beijing (China). Dept. of Mathematical Sciences; Zhao, D. [Tohoku Univ., Sendai (Japan). Dept. of Geophysics; Yang, D. [Tsinghua Univ., Beijing (China). Dept. of Mathematical Sciences


    High-resolution tomographic images of the crust and upper mantle in and around the area of the 2011 Iwaki earthquake (M 7.0) and the Fukushima nuclear power plant are determined by inverting a large number of high-quality arrival times with both the finite-frequency and ray tomography methods. The Iwaki earthquake and its aftershocks mainly occurred in a boundary zone with strong variations in seismic velocity and Poisson's ratio. Prominent low-velocity and high Poisson's ratio zones are revealed under the Iwaki source area and the Fukushima nuclear power plant, which may reflect fluids released from the dehydration of the subducting Pacific slab under Northeast Japan. The 2011 Tohoku-oki earthquake (Mw 9.0) caused static stress transfer in the overriding Okhotsk plate, resulting in the seismicity in the Iwaki source area that significantly increased immediately following the Tohoku-oki main-shock. Our results suggest that the Iwaki earthquake was triggered by the ascending fluids from the Pacific slab dehydration and the stress variation induced by the Tohoku-oki main-shock. The similar structures under the Iwaki source area and the Fukushima nuclear power plant suggest that the security of the nuclear power plant site should be strengthened to withstand potential large earthquakes in the future. (orig.)

  16. Tomography of the 2011 Iwaki earthquake (M 7.0 and Fukushima nuclear power plant area

    Directory of Open Access Journals (Sweden)

    P. Tong


    Full Text Available High-resolution tomographic images of the crust and upper mantle in and around the area of the 2011 Iwaki earthquake (M 7.0 and the Fukushima nuclear power plant are determined by inverting a large number of high-quality arrival times with both the finite-frequency and ray tomography methods. The Iwaki earthquake and its aftershocks mainly occurred in a boundary zone with strong variations in seismic velocity and Poisson's ratio. Prominent low-velocity and high Poisson's ratio zones are revealed under the Iwaki source area and the Fukushima nuclear power plant, which may reflect fluids released from the dehydration of the subducting Pacific slab under Northeast Japan. The 2011 Tohoku-oki earthquake (Mw 9.0 caused static stress transfer in the overriding Okhotsk plate, resulting in the seismicity in the Iwaki source area that significantly increased immediately following the Tohoku-oki mainshock. Our results suggest that the Iwaki earthquake was triggered by the ascending fluids from the Pacific slab dehydration and the stress variation induced by the Tohoku-oki mainshock. The similar structures under the Iwaki source area and the Fukushima nuclear power plant suggest that the security of the nuclear power plant site should be strengthened to withstand potential large earthquakes in the future.

  17. The 2008 M7.9 Wenchuan earthquake - a human-caused event (United States)

    Klose, C. D.


    A catalog of global human-caused earthquakes shows statistical evidence that the triggering of earthquakes by large-scale geoengineering activities depends on geological and tectonic constrains (in Klose 2013). Such geoengineering activities also include the filling of water reservoirs. This presentation illuminates mechanical and statistical aspects of the 2008 M7.9 Wenchuan earthquake in light of the hypothesis of being NOT human-caused. However, available data suggest that the Wenchuan earthquake was triggered by the filling of the Zipungpu water reservoir 30 months prior to the mainshock. The reservoir spatially extended parallel and near to the main Beichuan fault zone in a highly stressed reverse fault regime. It is mechanically evident that reverse faults tend to be very trigger-sensitive due to mass shifts (static loads) that occur on the surface of the Earth's crust. These circumstances made a triggering of a seismic event of this magnitude at this location possible (in Klose 2008, 2012). The data show that the Wenchuan earthquake is not an outlier. From a statistical view point, the earthquake falls into the upper range of the family of reverse fault earthquakes that were caused by humans worldwide.

  18. Landslides Triggered by the 12 May 2008, M 7.9 Wenchuan, China Earthquake (United States)

    Harp, E.; Jibson, R.; Godt, J.


    The 12 May 2008, M 7.9 Wenchuan earthquake in eastern Sichuan Province of China triggered tens of thousands of rock falls, rock slides, rock avalanches, and deep, complex, landslides. Of the approximately 87,000 deaths caused by the earthquake, more than 20,000 have been attributed to landsides. Numerous villages were buried by large landslides. Air-blasts resulting from the rapid failure and movement of landslides were observed and documented from numerous eye-witness accounts. More than 100 landslide-dammed lakes were created by the earthquake, 33 of which were evaluated to determine if spillway construction was necessary to minimize flooding by future breaching of the landslide dams. Spillways were ultimately constructed on at least 16 landslide dams. Preliminary observations in the field and from satellite imagery indicate that the most common types of landslides were rock falls and rock slides that ranged in size from several hundred cubic meters to several hundred thousand cubic meters in volume. There were hundreds to perhaps as many as one thousand landslides exceeding 1 million cubic meters in volume. The largest landslide identified using Jaxa's Alos/Prism satellite imagery (2.5 m resolution) is nearly 1 billion cubic meters in volume and is located approximately 12 km north-northeast of the city of Hanwang. This landslide appears to have resulted from the failure of a 1.5-km section of ridge crest that now occupies most of the adjacent valley to the northeast; its toe spills over the next ridge crest to the northeast. The satellite imagery of 4 June 2008 shows two small lakes dammed by the slide debris. Within the mountainous areas in the near-field zone of shaking, rock slides dammed chains of lakes in many drainages. Sections of streams 2-3 km long have been completely covered by rock debris as of the 4 June imagery The debris from the triggered landslides is being redistributed rapidly by post-earthquake rainfall. A 100-year rainstorm in September

  19. Macroscopic anomalies before the September 2010 M = 7.1 earthquake in Christchurch, New Zealand

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    Ü. Ulusoy


    Full Text Available Previous published work after the Kobe and İzmit earthquakes (1995 and 1999, respectively demonstrated some reported meteorological and animal behaviour precursors were valid. Predictions were freshly tested for the Christchurch earthquake (M = 7.1, 4 September 2010. An internet survey with nearly 400 valid replies showed relative numbers of reports in precursor categories the day before the quake, were statistically significantly different from those in the preceding three days (excess meteorological events and animal behaviour. The day before the quake, there was also altered relative precursor class occurrence within 56 km compared with further away. Both these confirmed the earlier published work. Owners were woken up by unique pet behaviour 12 times as often in the hour before the quake compared with other hours immediately before (statistically highly significant. Lost and Found pet reports were double normal the week before, and 4.5 times normal both the day before the quake, and 9 days before. (Results were again statistically significant. Unique animal behaviour before the quake was often repeated before the numerous aftershocks. These pet owners claimed an approximate 80% prediction reliability. However, a preliminary telephone survey suggested that animals showing any precursor response are a minority. Some precursors seem real, but usefulness seemed mostly restricted to 7 cases where owners were in, or near, a place of safety through disruptive pet behaviour, and one in which owners were diverted by a pet from being struck by falling fixtures. For a later 22 February 2011 M = 6.3 quake no reports of escape through warning by pets were recorded, which raises serious questions whether such prediction is practically useful, because lives claimed saved are extremely low compared with fatalities. It is shown the lost-pet statistics dates, correspond to ionospheric anomalies recorded using the GPS satellite system and geomagnetic

  20. The September 2017 M=8.1 Chiapas and M=7.1 Puebla, Mexico, earthquakes: Chain reaction or coincidence? (United States)

    Toda, S.; Stein, R. S.


    The M=8.1 and M=7.1 events struck 12 days and 600 km apart, both with an independent probability of occurrence of 0.5% per year, based on the GEAR model [Bird et al., 2015]. Are they related? First, we calculated the static stress imparted by the M=8.1 shock to the fault that ruptured in the M=7.1, and find a tiny push that would favor rupture. But the stress increase (0.2 kPa) is less than the fault would experience from the tidal stresses, and so it should be inconsequential. We next used the México Servicio Sismológico Nacional (UNAM) online catalog to look at the quakes in the month before the M=8.1 and in the 13 days since. We calculate the completeness to be M≥4.0. There are virtually no remote aftershocks from the Chiapas rupture that extend within 250 km of the M=7.1 shock during the first week after the M=8.1. So, if anything, the M=8.1 turned off for a week or more the region that ruptured in the M=7.1. Events started turning on about 2-3 days before the M=7.1, but none of those struck within 40 km of the future M=7.1 mainshock. The seismic surface waves unleashed by great earthquakes envelop the globe in just 160 minutes, and yet triggering of remote large aftershocks during these 2-3 hours is either very rare [Pollitz et al., Nature 2012] or in dispute [Fan & Shearer, 2016 vs. Yue et al., 2017]. So, the waves must trigger tiny shocks that cascade into larger shocks after some delay. Or, perhaps the stresses conveyed by the waves pump pockets of fluids that slowly diffuse into nearby fault zones, lubricating them to the point of failure [Parsons at al., 2017]. In the cases where great earthquakes are indisputably seen to trigger aftershocks at great distances or even globally, they to do so within several days, or a week at most. Since Puebla struck 12 days later, this seems to us too long a period to be explained by dynamic triggering. Even though neither quake on their own is rare, what's the chance of independent M=8.1 and M=7.1 events just 12

  1. Post-test analysis of components from selenide isotope generator modules M-7, M-15, and M-18

    International Nuclear Information System (INIS)

    Wei, G.C.; Keiser, J.R.; Crouse, R.S.; Allen, M.D.; Schaffhauser, A.C.


    Several critical components removed from SIG (Selenide Isotope Generator) thermoelectric modules M-7, M-15C, M-15D, and M-18 were examined. These modules failed to show the predicted stability and conversion efficiency. Understanding the degradation and identifying means for preventing it necessitated detailed post-test examinations of key parts in the modules. Steel springs, which provided pressure for contacts at the hot and cold ends of P- or N-legs, relaxed more than expected. Beryllium oxide insulators had dark deposits that caused electrical shorts. The GdSe 1 49 N-leg exhibited cracking. The (Cu,Ag) 2 Se P-leg lost weight or sublimed excessively in module M-7 and more than expected in the other modules

  2. Crystallization and preliminary crystallographic analysis of tRNA (m7G46) methyltransferase from Escherichia coli

    International Nuclear Information System (INIS)

    Liu, Qi; Gao, Yang; Yang, Weili; Zhou, Huihao; Gao, Yongxiang; Zhang, Xiao; Teng, Maikun; Niu, Liwen


    tRNA (m 7 G46) methyltransferase from E. coli was overexpressed, purified and crystallized. Diffraction data were collected to 2.04 Å resolution. Transfer RNA (tRNA) (m 7 G46) methyltransferase (TrmB) belongs to the Rossmann-fold methyltransferase (RFM) family and uses S-adenosyl-l-methionine (SAM) as the methyl-group donor to catalyze the formation of N 7 -methylguanosine (m 7 G) at position 46 in the variable loop of tRNAs. After attempts to crystallize full-length Escherichia coli TrmB (EcTrmB) failed, a truncated protein lacking the first 32 residues of the N-terminus but with an additional His 6 tag at the C-terminus was crystallized by the hanging-drop vapour-diffusion method using polyethylene glycol 3350 (PEG 3350) as precipitant at 283 K. An X-ray diffraction data set was collected using a single flash-cooled crystal that belonged to space group P2 1

  3. 7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity. (United States)

    Wypijewska, Anna; Bojarska, Elzbieta; Lukaszewicz, Maciej; Stepinski, Janusz; Jemielity, Jacek; Davis, Richard E; Darzynkiewicz, Edward


    Decapping scavenger (DcpS) enzymes catalyze the cleavage of a residual cap structure following 3' → 5' mRNA decay. Some previous studies suggested that both m(7)GpppG and m(7)GDP were substrates for DcpS hydrolysis. Herein, we show that mononucleoside diphosphates, m(7)GDP (7-methylguanosine diphosphate) and m(3)(2,2,7)GDP (2,2,7-trimethylguanosine diphosphate), resulting from mRNA decapping by the Dcp1/2 complex in the 5' → 3' mRNA decay, are not degraded by recombinant DcpS proteins (human, nematode, and yeast). Furthermore, whereas mononucleoside diphosphates (m(7)GDP and m(3)(2,2,7)GDP) are not hydrolyzed by DcpS, mononucleoside triphosphates (m(7)GTP and m(3)(2,2,7)GTP) are, demonstrating the importance of a triphosphate chain for DcpS hydrolytic activity. m(7)GTP and m(3)(2,2,7)GTP are cleaved at a slower rate than their corresponding dinucleotides (m(7)GpppG and m(3)(2,2,7)GpppG, respectively), indicating an involvement of the second nucleoside for efficient DcpS-mediated digestion. Although DcpS enzymes cannot hydrolyze m(7)GDP, they have a high binding affinity for m(7)GDP and m(7)GDP potently inhibits DcpS hydrolysis of m(7)GpppG, suggesting that m(7)GDP may function as an efficient DcpS inhibitor. Our data have important implications for the regulatory role of m(7)GDP in mRNA metabolic pathways due to its possible interactions with different cap-binding proteins, such as DcpS or eIF4E.

  4. Acoustic Emission Precursors of M6.0 2004 Parkfield and M7.0 1989Loma Prieta Earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Korneev, Valeri


    Two recent strike-slip earthquakes on the San Andreas Fault(SAF) in California, the M6.0 2004 Parkfield and M7.0 1989 Loma Prietaevents, revealed peaks in the acoustic emission (AE) activity in thesurrounding crust several months prior to the main events. Earthquakesdirectly within the SAF zone were intentionally excluded from theanalysis. The observed increase in AE is assumed to be a signature of theincreasing stress level in the surrounding crust, while the peak andsubsequent decrease in AE starting several months prior to the mainevents is attributed to damage-induced softening processes as discussedherein. Further, distinctive zones of low seismic activity surroundingthe epicentral regions in the pre-event time period are present for thetwo studied events. Both AE increases in the crust surrounding apotential future event and the development of a low-seismicity epicentralzone can be regarded as promising precursory information that could helpsignal the arrival of large earthquakes.

  5. 78 FR 22269 - International Conference on Harmonisation; Draft Guidance on M7 Assessment and Control of DNA... (United States)


    ...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance entitled ``M7 Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk.'' The draft guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The draft guidance emphasizes considerations of both safety and quality risk management in establishing levels of mutagenic impurities that are expected to pose negligible carcinogenic risk. It outlines recommendations for assessment and control of mutagenic impurities that reside or are reasonably expected to reside in a final drug substance or product, taking into consideration the intended conditions of human use. The draft guidance is intended to provide guidance for new drug substances and new drug products during their clinical development and subsequent applications for marketing.

  6. Comparison of edge detection techniques for M7 subtype Leukemic cell in terms of noise filters and threshold value

    Directory of Open Access Journals (Sweden)

    Abdul Salam Afifah Salmi


    Full Text Available This paper will focus on the study and identifying various threshold values for two commonly used edge detection techniques, which are Sobel and Canny Edge detection. The idea is to determine which values are apt in giving accurate results in identifying a particular leukemic cell. In addition, evaluating suitability of edge detectors are also essential as feature extraction of the cell depends greatly on image segmentation (edge detection. Firstly, an image of M7 subtype of Acute Myelocytic Leukemia (AML is chosen due to its diagnosing which were found lacking. Next, for an enhancement in image quality, noise filters are applied. Hence, by comparing images with no filter, median and average filter, useful information can be acquired. Each threshold value is fixed with value 0, 0.25 and 0.5. From the investigation found, without any filter, Canny with a threshold value of 0.5 yields the best result.

  7. Statistical features of seismoelectric signals prior to M7.4 Guerrero-Oaxaca earthquake (México

    Directory of Open Access Journals (Sweden)

    A. Ramírez-Rojas


    Full Text Available In this paper a statistical analysis of seismoelectric ULF signals prior to the M7.4 Guerrero-Oaxaca earthquake (EQ occurred at the Mexican Pacific coast on 14 September 1995, has been performed. The signals were simultaneously recorded at three monitoring stations from the last months of 1994 until July of 1996. The nonlinear time series methods of Higuchi fractal dimension (HFD and detrended fluctuation analysis (DFA have been used. In the three data sets we found some complex dynamical behaviors that seemingly reflect a relaxation-EQ preparation-main shock-relaxation process. In particular, clear spike-like anomalies in both DFA- and HFD-exponents some months before the main shock are revealed.

  8. Quantitative mapping of precursory seismic quiescence before the 1989, M 7.1off-Sanriku earthquake, Japan

    Directory of Open Access Journals (Sweden)

    N. Umino


    Full Text Available The first main shock of the off-Sanriku earthquake sequence (02/11/89, M 7.1; 18/07/92, M 6.9; 28/12/94, M 7.5 was preceded by a precursory seismic quiescence lasting 2.5 ± 1 year and up to this main shock. The detailed properties of this quiescence were mapped as a function of time and space by a gridding technique using the ZMAP computer code, and the statistical significance was estimated by generating a synthetic catalog based on the microearthquake catalog of Tohoku University, which was the data set used. The statistically most significant expression of this precursory quiescence has a probability of 0.1% to have occurred at random and was located in the eastern part of the 1989 aftershock area, at a point to which the 1994 aftershocks extended also. If we define the dimensions of the quiescence anomaly by a vertical cylinder with the depth of the entire seismogenic layer, centered at the point of most significant quiescence and showing a rate decrease of 75%, then we find its radius is 25 ± 9 km. If we allow other shapes, such as the simplified aftershock volume of 1989, or other simple geometric figures, to define the rate decrease we find dimensions of 80 by 80 km. The characteristics of the quiescence anomaly do not depend strongly on the choice of free parameters within the following ranges: 100 ? number of events ? 400, 2.0 ? Mmin £ 3.0, 1 ? time window ? 3 years. With our method, a thorough analysis of the period before the 1994 main shock is not possible because of the interference of the extended aftershock sequence of 1989. Nevertheless, we identified a quiescence of nearly zero earthquakes located near the center of the 1994 aftershock area that lasted for one year up to that main shock. However, this quiescence period ranked only 46th in significance, behind other quiescences of equal duration and similar dimensions distributed in time and space through the data set. Because of the ubiquitous existence of periods of near

  9. Rupture directivity and local site effects: the M7.3 Honduras earthquake of May 23, 2009 (United States)

    Shulman, D.; Mooney, W. D.


    On May 28, 2009, at 2:24 AM local time, a M 7.3 earthquake struck off the coast of Honduras on the Motagua-Swan Fault System (MSFS), part of the boundary between the North America and Caribbean plates. This plate boundary has an average slip rate of 20 mm/year. This left-lateral earthquake had an average slip of 1.5 m on a 100-km-long near-vertical fault plane (Hayes and Ji, 2009). The hypocenter depth is estimated at 10 km. The main shock caused 130 structures, including homes and office buildings, to collapse or suffer significant damage in northern Honduras. Seven deaths were reported. Due to a lack of recordings in the area, the available documentation of the local effects of this earthquake are the USGS "Did you feel it?" responses and the data collected during our field seismic intensity investigation. We conducted a field investigation in Honduras between May 30 and June 6, 2009, focused on areas with local reports of damage, including the cities of La Ceiba, El Progresso, San Pedro Sula, Puerto Cortes in northern Honduras and the island of Roatan in the Caribbean Sea. The damage ascertained at these five sites shows that the severity of damage did not decrease with distance from the epicenter as predicted by standard attenuation relations. Instead, a concentration of damage was observed in El Progresso, approximately 75 km directly south from the SW end of the rupture and 160 km from the epicenter. The island of Roatan, just 30 km from the epicenter, was graded as VI on the Modified Mercalli Intensity scale while, El Progresso was graded as VIII (one unit higher than “Did you feel it?”). These intensity anomalies can be explained by two factors: (1) SW-directed rupture propagation and proximity to a localized 3.0m slip pulse (asperity) that occurred near the SW end of the fault (Hayes and Ji, 2009) that focused energy toward the city of El Progress on the mainland and; (2) local site effects, particularly the Precambrian schists and gneisses on the

  10. Seismicity Precursors of the M6.0 2004 Parkfield and M7.0 1989Loma Prieta Earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Korneev, Valeri A.


    The M6.0 2004 Parkfield and M7.0 1989 Loma Prietastrike-slip earthquakes on the San Andreas Fault (SAF) were preceded byseismicity peaks occurring several months prior to the main events.Earthquakes directly within the SAF zone were intentionally excluded fromthe analysis because they manifest stress-release processes rather thanstress accumulation. The observed increase in seismicity is interpretedas a signature of the increasing stress level in the surrounding crust,whereas the peaks and the subsequent decrease in seismicity areattributed to damage-induced softening processes. Furthermore, in bothcases there is a distinctive zone of low seismic activity that surroundsthe epicentral region in the pre-event period. The increase of seismicityin the crust surrounding a potential future event and the development ofa low-seismicity epicentral zone can be regarded as promising precursoryinformation that could help signal the arrival of large earthquakes. TheGutenberg-Richter relationship (GRR) should allow extrapolation ofseismicity changes down to seismic noise level magnitudes. Thishypothesis is verified by comparison of seismic noise at 80 Hz with theParkfield M4 1993-1994 series, where noise peaks 5 months before theseries to about twice the background level.

  11. Final comparison report on ISP-35: Nupec hydrogen mixing and distribution test (Test M-7-1)

    International Nuclear Information System (INIS)


    This final comparison report summarizes the results of the OECD/CSNI sponsored ISP-35 exercise which was based on NUPEC's Hydrogen Mixing and Distribution Test M-7-1. 12 organizations from 10 different countries took part in the exercise. For the ISP-35 test, a steam/light gas (helium) mixture was released into the lower region of a simplified model of a PWR containment. At the same time, the dome cooling spray was also activated. the transient time histories for gas temperature and concentrations were recorded for each of the 25 compartments of the model containment. The wall temperatures as well as the dome pressure were also recorded. The ISP-35 participants simulated the test conditions and attempted to predict the time histories using their accident analysis codes. Results of these analyses are presented, and comparisons are made between the experimental data and the calculated data. In general, predictions for pressure, helium concentration and gas distribution patterns were achieved with acceptable accuracy

  12. Analysis of pre-earthquake ionospheric anomalies before the global M = 7.0+ earthquakes in 2010

    Directory of Open Access Journals (Sweden)

    W. F. Peng


    Full Text Available The pre-earthquake ionospheric anomalies that occurred before the global M = 7.0+ earthquakes in 2010 are investigated using the total electron content (TEC from the global ionosphere map (GIM. We analyze the possible causes of the ionospheric anomalies based on the space environment and magnetic field status. Results show that some anomalies are related to the earthquakes. By analyzing the time of occurrence, duration, and spatial distribution of these ionospheric anomalies, a number of new conclusions are drawn, as follows: earthquake-related ionospheric anomalies are not bound to appear; both positive and negative anomalies are likely to occur; and the earthquake-related ionospheric anomalies discussed in the current study occurred 0–2 days before the associated earthquakes and in the afternoon to sunset (i.e. between 12:00 and 20:00 local time. Pre-earthquake ionospheric anomalies occur mainly in areas near the epicenter. However, the maximum affected area in the ionosphere does not coincide with the vertical projection of the epicenter of the subsequent earthquake. The directions deviating from the epicenters do not follow a fixed rule. The corresponding ionospheric effects can also be observed in the magnetically conjugated region. However, the probability of the anomalies appearance and extent of the anomalies in the magnetically conjugated region are smaller than the anomalies near the epicenter. Deep-focus earthquakes may also exhibit very significant pre-earthquake ionospheric anomalies.

  13. Observations and recommendations regarding landslide hazards related to the January 13, 2001 M-7.6 El Salvador earthquake (United States)

    Jibson, Randall W.; Crone, Anthony J.


    The January 13, 2001 earthquake (M-7.6) off the coast of El Salvador triggered widespread damaging landslides in many parts of the El Salvador. In the aftermath of the earthquake, the Salvadoran government requested technical assistance through the U.S. Agency for International Development (USAID); USAID, in turn, requested help from technical experts in landslide hazards from the U.S. Geological Survey. In response to that request, we arrived in El Salvador on January 31, 2001 and worked with USAID personnel and Salvadoran agency counterparts in visiting landslide sites and evaluating present and potential hazards. A preliminary, unofficial report was prepared at the end of our trip (February 9) to provide immediate information and assistance to interested agencies and parties. The current report is an updated and somewhat expanded version of that unofficial report. Because of the brief nature of this report, conclusions and recommendations contained herein should be considered tentative and may be revised in the future.

  14. Rapid earthquake characterization using MEMS accelerometers and volunteer hosts following the M 7.2 Darfield, New Zealand, Earthquake (United States)

    Lawrence, J. F.; Cochran, E.S.; Chung, A.; Kaiser, A.; Christensen, C. M.; Allen, R.; Baker, J.W.; Fry, B.; Heaton, T.; Kilb, Debi; Kohler, M.D.; Taufer, M.


    We test the feasibility of rapidly detecting and characterizing earthquakes with the Quake‐Catcher Network (QCN) that connects low‐cost microelectromechanical systems accelerometers to a network of volunteer‐owned, Internet‐connected computers. Following the 3 September 2010 M 7.2 Darfield, New Zealand, earthquake we installed over 180 QCN sensors in the Christchurch region to record the aftershock sequence. The sensors are monitored continuously by the host computer and send trigger reports to the central server. The central server correlates incoming triggers to detect when an earthquake has occurred. The location and magnitude are then rapidly estimated from a minimal set of received ground‐motion parameters. Full seismic time series are typically not retrieved for tens of minutes or even hours after an event. We benchmark the QCN real‐time detection performance against the GNS Science GeoNet earthquake catalog. Under normal network operations, QCN detects and characterizes earthquakes within 9.1 s of the earthquake rupture and determines the magnitude within 1 magnitude unit of that reported in the GNS catalog for 90% of the detections.

  15. Shallow microearthquakes near Chongqing, China triggered by the Rayleigh waves of the 2015 M7.8 Gorkha, Nepal earthquake (United States)

    Han, Libo; Peng, Zhigang; Johnson, Christopher W.; Pollitz, Fred F.; Li, Lu; Wang, Baoshan; Wu, Jing; Li, Qiang; Wei, Hongmei


    We present a case of remotely triggered seismicity in Southwest China by the 2015/04/25 M7.8 Gorkha, Nepal earthquake. A local magnitude ML3.8 event occurred near the Qijiang district south of Chongqing city approximately 12 min after the Gorkha mainshock. Within 30 km of this ML3.8 event there are 62 earthquakes since 2009 and only 7 ML > 3 events, which corresponds to a likelihood of 0.3% for a ML > 3 on any given day by a random chance. This observation motivates us to investigate the relationship between the ML3.8 event and the Gorkha mainshock. The ML3.8 event was listed in the China Earthquake National Center (CENC) catalog and occurred at shallow depth (∼3 km). By examining high-frequency waveforms, we identify a smaller local event (∼ML 2.5) ∼ 15 s before the ML3.8 event. Both events occurred during the first two cycles of the Rayleigh waves from the Gorkha mainshock. We perform seismic event detection based on envelope function and waveform matching by using the two events as templates. Both analyses found a statistically significant rate change during the mainshock, suggesting that they were indeed dynamically triggered by the Rayleigh waves. Both events occurred during the peak normal and dilatational stress changes (∼10-30 kPa), consistent with observations of dynamic triggering in other geothermal/volcanic regions. Although other recent events (i.e., the 2011 M9.1 Tohoku-Oki earthquake) produced similar peak ground velocities, the 2015 Gorkha mainshock was the only event that produced clear dynamic triggering in this region. The triggering site is close to hydraulic fracturing wells that began production in 2013-2014. Hence we suspect that fluid injections may increase the region's susceptibility to remote dynamic triggering.

  16. Strong ground motion in Port-au-Prince, Haiti, during the M7.0 12 January 2010 Haiti earthquake (United States)

    Hough, Susan E; Given, Doug; Taniguchi, Tomoyo; Altidor, J.R.; Anglade, Dieuseul; Mildor, S-L.


    No strong motion records are available for the 12 January 2010 M7.0 Haiti earthquake. We use aftershock recordings as well as detailed considerations of damage to estimate the severity and distribution of mainshock shaking in Port-au-Prince. Relative to ground motions at a hard - rock reference site, peak accelerations are amplified by a factor of approximately 2 at sites on low-lying deposits in central Port-au-Prince and by a factor of 2.5 - 3.5 on a steep foothill ridge in the southern Port-au-Prince metropolitan region. The observed amplification along the ridge cannot be explained by sediment - induced amplification , but is consistent with predicted topographic amplification by a steep, narrow ridge. Although damage was largely a consequence of poor construction , the damage pattern inferred from analysis of remote sensing imagery provides evidence for a correspondence between small-scale (0.1 - 1.0 km) topographic relief and high damage. Mainshock shaking intensity can be estimated crudely from a consideration of macroseismic effects . We further present detailed, quantitative analysis of the marks left on a tile floor by an industrial battery rack displaced during the mainshock, at the location where we observed the highest weak motion amplifications. Results of this analysis indicate that mainshock shaking was significantly higher at this location (~0.5 g , MMI VIII) relative to the shaking in parts of Port-au-Prince that experienced light damage. Our results further illustrate how observations of rigid body horizontal displacement during earthquakes can be used to estimate peak ground accelerations in the absence of instrumental data .

  17. Growth of a Structure Connecting the 2010 M 7.2 El Mayor - Cucapah Rupture with the Elsinore Faul (United States)

    Donnellan, A.; Parker, J. W.


    The M 7.2 El Mayor - Cucapah earthquake occurred on 4 April 2010 in the northern part of Baja, Mexico. The rupture extended about 120 km from near the northern tip of the Gulf of California to the US - Mexican border south of the Elsinore fault zone. Most of the aftershocks occurred within days of the main event. On 14 June 2010 a M 5.7 late aftershock occurred 8 km southeast of Ocotillo, CA and is the largest aftershock in the sequence. The right-lateral event occurred in a cluster of aftershocks and was followed by its own aftershock sequence. UAVSAR data were collected for a swath covering the aftershock on 13 April, 2010 just after the El Mayor - Cucapah earthquake and before the earthquake on 21 October 2009. The line was reflown 1 July 2010 after the M 5.7 14 June 2010 aftershock. Data have been continued to be collected semi yearly to yearly since then. Repeat Pass Interferomety (RPI) products spanning the aftershock show the growth of a lineament that with an azimuth of 121.5° or a strike of -58.5°. The interferograms suggest that a stepover develops following the earthquake. The epicenter of the M 5.7 aftershock is proximal to the linear discontinuity in the postseismic interferogram and the mechanism of the event is consistent with slip on this stepover. Inversions for slip on the northeast linear structure that steps west of the mainshock rupture yield a moment magnitude ranging from 5.5 - 5.8, which is consistent with the magnitude of the aftershock. Slip occurs at a depth of 2-10 km on a steeply dipping fault.

  18. Characterization of the Fault Core and Damage Zone of the Borrego Fault, 2010 M7.2 Rupture (United States)

    Dorsey, M. T.; Rockwell, T. K.; Girty, G.; Ostermeijer, G.; Mitchell, T. M.; Fletcher, J. M.


    We collected a continuous sample of the fault core and 23 samples of the damage zone out to 52 m across the rupture trace of the 2010 M7.2 El Mayor-Cucapa earthquake to characterize the physical damage and chemical transformations associated with this active seismic source. In addition to quantifying fracture intensity from macroscopic analysis, we cut a continuous thin section through the fault core and from various samples in the damage zone, and ran each sample for XRD analyses for clay mineralogy, XRF for bulk geochemical analyses, and bulk and grain density from which porosity and volumetric strain were derived. The parent rock is a hydrothermally-altered biotite tonalite, with biotite partially altered to chlorite. The presence of epidote with chlorite suggests that these rocks were subjected to relatively high temperatures of 300-400° C. Adjacent to the outermost damage zone is a chaotic breccia zone with distinct chemical and physical characteristics, indicating possible connection to an ancestral fault to the southwest. The damage zone consists of an outer zone of protocataclasite, which grades inward towards mesocataclasite with seams of ultracataclasite. The fault core is anomalous in that it is largely composed of a sliver of marble that has been translated along the fault, so direct comparison with the damage zone is impaired. From collected data, we observe that chloritization increases into the breccia and damage zones, as does the presence of illite. Porosity reaches maximum values in the damage zone adjacent to the core, and closely follows trends in fracture intensity. Statistically significant gains in Mg, Na, K, Mn, and total bulk mass occurred within the inner damage zone, with losses of Ca and P mass, which led to the formation of chlorite and albite. The outer damage zone displays gains in Mg and Na mass with losses in Ca and P mass. The breccia zone shows gains in mass of Mg and Mn and loss in total bulk mass. A gain in LOI in both the

  19. Reevaluation of 1935 M 7.0 earthquake fault, Miaoli-Taichung Area, western Taiwan: a DEM and field study (United States)

    Lin, Y. N.; Chen, Y.; Ota, Y.


    A large earthquake (M 7.0) took place in Miaoli area, western Taiwan on April 21st, 1935. Right to its south is the 1999 Chi-Chi earthquake fault, indicating it is not only tectonically but seismically active. As the previous study, the study area is located in the mature zone of a tectonic collision that occurred between Philippine sea Plate and Eurasia continental Plate. The associated surface ruptures of 1935 earthquake daylighted Tungtsichiao Fault, a tear fault trending NE in the south and Chihhu Fault, a back thrust trending N-S in the north, but no ruptures occurred in between. Strike-slip component was identified by the horizontal offset observed along Tungtsichiao Fault; however, there are still disputes on the reported field evidence. Our purposes are (1) to identify the structural behaviors of these two faults, (2) to find out what the seismogenic structure is, and (3) to reconstruct the regional geology by information given by this earthquake. By DEM interpretation and field survey, we can clearly recognize a lot of the 1935 associated features. In the west of Chihhu Fault, a series of N-S higher terraces can be identified with eastward tilted surfaces and nearly 200 m relative height. Another lower terrace is also believed being created during the 1935 earthquake, showing an east-facing scarp with a height of ca. 1.5~2 m. Outcrop investigation reveals that the late-Miocene bedrock has been easterly thrusted over the Holocene conglomerates, indicating a west-dipping fault plane. The Tungtsichiao Fault cuts through a lateritic terrace at Holi, which is supposed developed in Pleistocene. The fault scarp is only discernible in the northeastern ending. Other noticeable features are the fault related antiforms that line up along the surface rupture. There is no outcrop to show the fault geometry among bedrocks. We re-interpret the northern Chihhu Fault as the back thrust generated from a main subsurface detachment, which may be the actual seismogenic fault

  20. Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

    Energy Technology Data Exchange (ETDEWEB)

    Devarkar, Swapnil C.; Wang, Chen; Miller, Matthew T.; Ramanathan, Anand; Jiang, Fuguo; Khan, Abdul G.; Patel, Smita S.; Marcotrigiano, Joseph


    The cytosolic innate immune receptor Retinoic Acid Inducible Gene-I (RIG-I) is the principal detector of pathogenic RNAs carrying a 5'-triphosphate (5'ppp). Self RNAs like mRNAs evade recognition by RIG-I due to posttranscriptional modifications like 5'-end capping with 7-methyl guanosine (m7G) and 2'-O-methylation of 5'-end nucleotides. Viruses have also evolved mechanisms to mimic these modifications, which in part is believed to aid in immune evasion. Currently, it is unclear how these modifications modulate RIG-I recognition. This paper provides structural and mechanistic insights into the roles of the m7G cap and 2'-O-methylation in RIG-I evasion. We show that RIG-I accommodates the m7G base while maintaining the 5'ppp contacts and can recognize Cap-0 RNAs but not Cap-1.

  1. Expression of M6 and M7 lysin in Mytilus edulis is not restricted to sperm, but occurs also in oocytes and somatic tissue of males and females. (United States)

    Heß, Anne-Katrin; Bartel, Manuela; Roth, Karina; Messerschmidt, Katrin; Heilmann, Katja; Kenchington, Ellen; Micheel, Burkhard; Stuckas, Heiko


    Sperm proteins of marine sessile invertebrates have been extensively studied to understand the molecular basis of reproductive isolation. Apart from molecules such as bindin of sea urchins or lysin of abalone species, the acrosomal protein M7 lysin of Mytilus edulis has been analyzed. M7 lysin was found to be under positive selection, but mechanisms driving the evolution of this protein are not fully understood. To explore functional aspects, this study investigated the protein expression pattern of M7 and M6 lysin in gametes and somatic tissue of male and female M. edulis. The study employs a previously published monoclonal antibody (G26-AG8) to investigate M6 and M7 lysin protein expression, and explores expression of both genes. It is shown that these proteins and their encoding genes are expressed in gametes and somatic tissue of both sexes. This is in contrast to sea urchin bindin and abalone lysin, in which gene expression is strictly limited to males. Although future studies need to clarify the functional importance of both acrosomal proteins in male and female somatic tissue, new insights into the evolution of sperm proteins in marine sessile invertebrates are possible. This is because proteins with male-specific expression (bindin, lysin) might evolve differently than proteins with expression in both sexes (M6/M7 lysin), and the putative function of both proteins in females opens the possibility that the evolution of M6/M7 lysin is under sexual antagonistic selection, for example, mutations beneficial to the acrosomal function that are less beneficial the function in somatic tissue of females. Copyright © 2012 Wiley Periodicals, Inc.

  2. Stress rotations due to the M6.5 foreshock and M7.3 main shock in the 2016 Kumamoto, SW Japan, earthquake sequence (United States)

    Yoshida, Keisuke; Hasegawa, Akira; Saito, Tatsuhiko; Asano, Youichi; Tanaka, Sachiko; Sawazaki, Kaoru; Urata, Yumi; Fukuyama, Eiichi


    A shallow M7.3 event with a M6.5 foreshock occurred along the Futagawa-Hinagu fault zone in Kyushu, SW Japan. We investigated the spatiotemporal variation of the stress orientations in and around the source area of this 2016 Kumamoto earthquake sequence by inverting 1218 focal mechanisms. The results show that the σ3 axis in the vicinity of the fault plane significantly rotated counterclockwise after the M6.5 foreshock and rotated clockwise after the M7.3 main shock in the Hinagu fault segment. This observation indicates that a significant portion of the shear stress was released both by the M6.5 foreshock and M7.3 main shock. It is estimated that the stress release by the M6.5 foreshock occurred in the shallower part of the Hinagu fault segment, which brought the stress concentration in its deeper part. This might have caused the M7.3 main shock rupture mainly along the deeper part of the Hinagu fault segment after 28 h.

  3. Testing for adaptive evolution of the female reproductive protein ZPC in mammals, birds and fishes reveals problems with the M7-M8 likelihood ratio test. (United States)

    Berlin, Sofia; Smith, Nick G C


    Adaptive evolution appears to be a common feature of reproductive proteins across a very wide range of organisms. A promising way of addressing the evolutionary forces responsible for this general phenomenon is to test for adaptive evolution in the same gene but among groups of species, which differ in their reproductive biology. One can then test evolutionary hypotheses by asking whether the variation in adaptive evolution is consistent with the variation in reproductive biology. We have attempted to apply this approach to the study of a female reproductive protein, zona pellucida C (ZPC), which has been previously shown by the use of likelihood ratio tests (LRTs) to be under positive selection in mammals. We tested for evidence of adaptive evolution of ZPC in 15 mammalian species, in 11 avian species and in six fish species using three different LRTs (M1a-M2a, M7-M8, and M8a-M8). The only significant findings of adaptive evolution came from the M7-M8 test in mammals and fishes. Since LRTs of adaptive evolution may yield false positives in some situations, we examined the properties of the LRTs by several different simulation methods. When we simulated data to test the robustness of the LRTs, we found that the pattern of evolution in ZPC generates an excess of false positives for the M7-M8 LRT but not for the M1a-M2a or M8a-M8 LRTs. This bias is strong enough to have generated the significant M7-M8 results for mammals and fishes. We conclude that there is no strong evidence for adaptive evolution of ZPC in any of the vertebrate groups we studied, and that the M7-M8 LRT can be biased towards false inference of adaptive evolution by certain patterns of non-adaptive evolution.

  4. Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism. (United States)

    Shaheen, Ranad; Abdel-Salam, Ghada M H; Guy, Michael P; Alomar, Rana; Abdel-Hamid, Mohamed S; Afifi, Hanan H; Ismail, Samira I; Emam, Bayoumi A; Phizicky, Eric M; Alkuraya, Fowzan S


    Primordial dwarfism is a state of extreme prenatal and postnatal growth deficiency, and is characterized by marked clinical and genetic heterogeneity. Two presumably unrelated consanguineous families presented with an apparently novel form of primordial dwarfism in which severe growth deficiency is accompanied by distinct facial dysmorphism, brain malformation (microcephaly, agenesis of corpus callosum, and simplified gyration), and severe encephalopathy with seizures. Combined autozygome/exome analysis revealed a novel missense mutation in WDR4 as the likely causal variant. WDR4 is the human ortholog of the yeast Trm82, an essential component of the Trm8/Trm82 holoenzyme that effects a highly conserved and specific (m(7)G46) methylation of tRNA. The human mutation and the corresponding yeast mutation result in a significant reduction of m(7)G46 methylation of specific tRNA species, which provides a potential mechanism for primordial dwarfism associated with this lesion, since reduced m(7)G46 modification causes a growth deficiency phenotype in yeast. Our study expands the number of biological pathways underlying primordial dwarfism and adds to a growing list of human diseases linked to abnormal tRNA modification.

  5. Microstructure and wear resistance of Al2O3-M7C3/Fe composite coatings produced by laser controlled reactive synthesis (United States)

    Tan, Hui; Luo, Zhen; Li, Yang; Yan, Fuyu; Duan, Rui


    Based on the principle of thermite reaction of Al and Fe2O3 powders, the Al2O3 ceramic reinforced Fe-based composite coatings were fabricated on a steel substrate by laser controlled reactive synthesis and cladding. The effects of different additions of thermite reactants on the phase transition, microstructure evolution, microhardness and wear resistance of the composite coatings were investigated by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Vickers microhardness and block-on-ring wear test, respectively. The results show that Al2O3 ceramic and M7C3 carbide are in situ synthesized via the laser controlled reactive synthesis. The Al2O3 ceramic and M7C3 carbides prefer to distribute along the γ-Fe phase boundary continuously, which separates the γ-Fe matrix and is beneficial to the grain refinement. With the increase of thermite reactants, the amount of Al2O3 ceramic and M7C3 carbide in the composite coatings increases gradually. Moreover the cladding layer changes from dendritic structure to columnar structure and martensite structure in the heat affected zone becomes coarse. The increased thermite reactants improve the microhardness and wear resistance of the in situ composite coatings obviously and enhance the hardness of the heat affected zone, which should be ascribed to the grain refinement, ceramic and carbide precipitation and solid solution strengthening.

  6. Development and Validation of a Liquid Medium (M7H9C) for Routine Culture of Mycobacterium avium subsp. paratuberculosis To Replace Modified Bactec 12B Medium (United States)

    Whittington, Ann-Michele; Waldron, Anna; Begg, Douglas J.; de Silva, Kumi; Purdie, Auriol C.; Plain, Karren M.


    Liquid culture of Mycobacterium avium subsp. paratuberculosis from clinical samples, such as feces, is the most sensitive antemortem test for the diagnosis of Johne's disease in ruminants. In Australia, New Zealand, the United States, and some other countries, the Bactec 460 system with modified Bactec 12B medium (Becton, Dickinson) has been the most commonly used liquid culture system, but it was discontinued in 2012. In this study, a new liquid culture medium, M7H9C, was developed. It consists of a Middlebrook 7H9 medium base with added Casitone, albumin, dextrose, catalase, egg yolk, mycobactin J, and a cocktail of antibiotics. We found that polyoxyethylene stearate (POES) was not essential for the cultivation of M. avium subsp. paratuberculosis in either the Bactec 12B or the M7H9C medium. The limit of detection determined using pure cultures of the C and S strains of M. avium subsp. paratuberculosis was 7 bacilli per 50 μl inoculum in the two media. The new medium was validated using 784 fecal and tissue samples from sheep and cattle, >25% of which contained viable M. avium subsp. paratuberculosis. Discrepant results for the clinical samples between the two media were mostly associated with samples that contained <10 viable bacilli per gram, but these results were relatively uncommon, and the performances of the two media were not significantly different. M7H9C medium was less than half the cost of the Bactec 12B medium and did not require regular examination during incubation, but a confirmatory IS900 PCR test had to be performed on every culture after the predetermined incubation period. PMID:24048541

  7. Behavior of the monophosphate tungsten bronzes (PO2)4(WO3)2m (m = 7 and 8) in the course of electrochemical lithium insertion

    International Nuclear Information System (INIS)

    Martinez-de la Cruz, A.; Longoria Rodriguez, F.E.; Gonzalez, Lucy T.; Torres-Martinez, Leticia M.


    The electrochemical lithium insertion process has been studied in the family of monophosphate tungsten bronzes (PO 2 ) 4 (WO 3 ) 2m , where m = 7 and 8. Structural changes in the pristine oxides were followed as lithium insertion proceeded. Through potentiostatic intermittent technique the different processes which take place in the cathode during the discharge of the cell were analyzed. The nature of the bronzes Li x (PO 2 ) 4 (WO 3 ) 2m formed was determined by in situ X-ray diffraction experiments. These results have allowed establishing a correlation with the reversible/irreversible processes detected during the electrochemical lithium insertion

  8. Strong-motion observations of the M 7.8 Gorkha, Nepal, earthquake sequence and development of the N-shake strong-motion network (United States)

    Dixit, Amod; Ringler, Adam; Sumy, Danielle F.; Cochran, Elizabeth S.; Hough, Susan E.; Martin, Stacey; Gibbons, Steven; Luetgert, James H.; Galetzka, John; Shrestha, Surya; Rajaure, Sudhir; McNamara, Daniel E.


    We present and describe strong-motion data observations from the 2015 M 7.8 Gorkha, Nepal, earthquake sequence collected using existing and new Quake-Catcher Network (QCN) and U.S. Geological Survey NetQuakes sensors located in the Kathmandu Valley. A comparison of QCN data with waveforms recorded by a conventional strong-motion (NetQuakes) instrument validates the QCN data. We present preliminary analysis of spectral accelerations, and peak ground acceleration and velocity for earthquakes up to M 7.3 from the QCN stations, as well as preliminary analysis of the mainshock recording from the NetQuakes station. We show that mainshock peak accelerations were lower than expected and conclude the Kathmandu Valley experienced a pervasively nonlinear response during the mainshock. Phase picks from the QCN and NetQuakes data are also used to improve aftershock locations. This study confirms the utility of QCN instruments to contribute to ground-motion investigations and aftershock response in regions where conventional instrumentation and open-access seismic data are limited. Initial pilot installations of QCN instruments in 2014 are now being expanded to create the Nepal–Shaking Hazard Assessment for Kathmandu and its Environment (N-SHAKE) network.

  9. Synthesis and luminescent properties of novel red-emitting M7Sn(PO46:Eu3+ (M = Sr, Ba phosphors

    Directory of Open Access Journals (Sweden)

    Guo Feng


    Full Text Available Novel Eu3+-activated M7Sn(PO46 (where M = Sr, Ba red-emitting phosphors were synthesized via conventional solid-state reaction method at 1200 °C for 2 h. The luminescence properties of the prepared samples and quenching concentration of Sr7-xSn(PO46:xEu3+ and Ba7-xSn(PO46:xEu3+ were investigated. These phosphors can be efficiently excited by UV (395 nm and visible blue (465 nm light nicely matching the output wavelengths of the near-UV LEDs and InGaN blue LED chips and emit the red light. The critical concentrations of the Eu3+ activator were found to be 0.175 mol and 0.21 mol per formula unit for Sr7-xSn(PO46:xEu3+ and Ba7-xSn(PO46:xEu3+, respectively. The M7-xSn(PO46:xEu3+ (M = Sr, Ba phosphor may be a good candidate for light-emitting diodes application.

  10. Effects of MgO on short and long term stabilities in water of R7T7 and M7 nuclear waste glasses

    Energy Technology Data Exchange (ETDEWEB)

    Advocat, T; Vernaz, E; Dussossoy, J [CEA Centre d` Etudes de la Vallee du Rhone, 30 - Marcoule (France). Dept. des Procedes de Retraitement; Crovisier, J L [Centre National de la Recherche Scientifique (CNRS), 67 - Strasbourg (France)


    Magnesium oxide was added to the standard R7T7 and M7 glass compositions developed for containment of fission product solutions. M7 differs from the R7T7 reference glass mainly by a larger proportion of network modifier elements and a correspondingly lower proportion of glass network forming elements. The percentage of fission products, simulated in this study by inactive elements, was the same in both cases. Increasing the MgO content of the glass compositions by 2 to 5 wt% resulted in significant variations in the aqueous leaching resistance at 90 and 100 deg C. Experimental findings demonstrated that the initial dissolution rate measured at 100 deg C in a Soxhlet apparatus was proportional to the MgO content and inversely proportional to the network former content (mainly SiO2). This was confirmed by a glass hydration model based on the thermodynamic stability of the glass matrix components. Aqueous corrosion tests were also conducted at 90 deg C under static conditions at various SA/V ratios to simulate the progress of the reaction. Under these conditions, the glass dissolution rate diminished more slowly in time when the initial magnesium content was high and the network former content was low. This may be due primarily to a variation in the glass silica solubility limit related to the glass composition; it may also be related to the formation of secondary silica and magnesia alteration products controlling the glass dissolution reaction affinity.

  11. Palladium-Catalyzed, N-(2-Aminophenyl)acetamide-Assisted Ortho-Arylation of Substituted Benzamides: Application to the Synthesis of Urolithins B, M6, and M7. (United States)

    Reddy, M Damoder; Blanton, Alexandra N; Watkins, E Blake


    Pd-catalyzed, selective, monoarylation of ortho-C-H bonds of various benzamides with aryl/heteroaryl iodides has been realized using N-(2-aminophenyl)acetamide (APA) as a new bidentate directing group for the first time. The reaction was tolerant of a wide range of functional groups, and a variety of biaryl amide derivatives were successfully prepared in good to moderate yield. The utilization of N-(2-aminophenyl)acetamide as a novel directing group, Mn(OAc) 2 as a co-oxidant (silver free reaction conditions), and absolute ortho-monoaryl selectivity are notable features of this reaction. In addition, the obtained monoarylated products could be further transformed into the bioactive natural products and human microflora metabolites of dietary ellagic acid derivatives, urolithin B, urolithin M6, and urolithin M7.

  12. UAVSAR observations of triggered slip on the Imperial, Superstition Hills, and East Elmore Ranch Faults associated with the 2010 M 7.2 El Mayor-Cucapah earthquake (United States)

    Donnellan, Andrea; Parker, Jay; Hensley, Scott; Pierce, Marlon; Wang, Jun; Rundle, John


    4 April 2010 M 7.2 El Mayor-Cucapah earthquake that occurred in Baja California, Mexico and terminated near the U.S. Mexican border caused slip on the Imperial, Superstition Hills, and East Elmore Ranch Faults. The pattern of slip was observed using radar interferometry from NASA's Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) instrument collected on 20-21 October 2009 and 12-13 April 2010. Right-lateral slip of 36 ± 9 and 14 ± 2 mm occurred on the Imperial and Superstition Hills Faults, respectively. Left-lateral slip of 9 ± 2 mm occurred on the East Elmore Ranch Fault. The widths of the zones of displacement increase northward suggesting successively more buried fault motion to the north. The observations show a decreasing pattern of slip northward on a series of faults in the Salton Trough stepping between the El Mayor-Cucapah rupture and San Andreas Fault. Most of the motion occurred at the time of the M 7.2 earthquake and the UAVSAR observations are consistent with field, creepmeter, GPS, and Envisat observations. An additional 28 ± 1 mm of slip at the southern end of the Imperial Fault over a <1 km wide zone was observed over a 1 day span a week after the earthquake suggesting that the fault continued to slip at depth following the mainshock. The total moment release on the three faults is 2.3 × 1023-1.2 × 1024 dyne cm equivalent to a moment magnitude release of 4.9-5.3, assuming shallow slip depths ranging from 1 to 5 km.

  13. Some statistical features of the seismic activity related to the recent M8.2 and M7.1 earthquakes in Mexico (United States)

    Guzman, L.; Baeza-Blancas, E.; Reyes, I.; Angulo Brown, F.; Rudolf Navarro, A.


    By studying the magnitude earthquake catalogs, previous studies have reported evidence that some changes in the spatial and temporal organization of earthquake activity is observedbefore and after of a main-shock. These previous studies have used different approach methods for detecting clustering behavior and distance-events density in order topoint out the asymmetric behavior of before shocks and aftershocks. Here, we present a statistical analysis of the seismic activity related to the M8.2 and M7.1 earthquakes occurredon Sept. 7th and Sept. 19th, respectively. First, we calculated the interevent time and distance for the period Sept. 7th 2016 until Oct. 20th 2017 for each seismic region ( a radius of 150 km centeredat coordinates of the M8.1 and M7.1). Next, we calculated the "velocity" of the walker as the ratio between the interevent distance and interevent time, and similarly, we also constructed the"acceleration". A slider pointer is considered to estimate some statistical features within time windows of size τ for the velocity and acceleration sequences before and after the main shocks. Specifically, we applied the fractal dimension method to detect changes in the correlation (persistence) behavior of events in the period before the main events.Our preliminary results pointed out that the fractal dimension associated to the velocity and acceleration sequences exhibits changes in the persistence behavior before the mainshock, while thescaling dimension values after the main events resemble a more uncorrelated behavior. Moreover, the relationship between the standard deviation of the velocity and the local mean velocity valuefor a given time window-size τ is described by an exponent close to 1.5, and the cumulative distribution of velocity and acceleration are well described by power law functions after the crash and stretched-exponential-like distribution before the main shock. On the other hand, we present an analysis of patterns of seismicquiescence

  14. Real-Time Science on Social Media: The Example of Twitter in the Minutes, Hours, Days after the 2015 M7.8 Nepal Earthquake (United States)

    Lomax, A.; Bossu, R.; Mazet-Roux, G.


    Scientific information on disasters such as earthquakes typically comes firstly from official organizations, news reports and interviews with experts, and later from scientific presentations and peer-reviewed articles. With the advent of the Internet and social media, this information is available in real-time from automated systems and within a dynamic, collaborative interaction between scientific experts, responders and the public. After the 2015 M7.8 Nepal earthquake, Twitter Tweets from earth scientists* included information, analysis, commentary and discussion on earthquake parameters (location, size, mechanism, rupture extent, high-frequency radiation, …), earthquake effects (distribution of felt shaking and damage, triggered seismicity, landslides, …), earthquake rumors (e.g. the imminence of a larger event) and other earthquake information and observations (aftershock forecasts, statistics and maps, source and regional tectonics, seismograms, GPS, InSAR, photos/videos, …).In the future (while taking into account security, false or erroneous information and identity verification), collaborative, real-time science on social media after a disaster will give earlier and better scientific understanding and dissemination of public information, and enable improved emergency response and disaster management.* A sample of scientific Tweets after the 2015 Nepal earthquake: In the first minutes: "mb5.9 Mwp7.4 earthquake Nepal 2015.04.25-06:11:25UTC", "Major earthquake shakes Nepal 8 min ago", "Epicenter between Pokhara and Kathmandu", "Major earthquake shakes Nepal 18 min ago. Effects derived from witnesses' reports". In the first hour: "shallow thrust faulting to North under Himalayas", "a very large and shallow event ... Mw7.6-7.7", "aftershocks extend east and south of Kathmandu, so likely ruptured beneath city", "Valley-blocking landslides must be a very real worry". In the first day: "M7.8 earthquake in Nepal 2hr ago: destructive in Kathmandu Valley and

  15. The 2015 M7.2 Sarez, Central Pamir, Earthquake And The Importance Of Strike-Slip Faulting In The Pamir Interior: Insights From Geodesy And Field Observations (United States)

    Metzger, Sabrina; Schurr, Bernd; Ratschbacher, Lothar; Schöne, Tilo; Kufner, Sofia-Katerina; Zhang, Yong; Sudhaus, Henriette


    The Pamir mountain range, located in the Northwest of the India-Asia collision zone, accommodates approximately one third of the northward advance of the Indian continent at this longitude (i. e. ˜34 mm/yr) mostly by shortening at its northern thrust system. Geodetic and seismic data sets reveal here a narrow zone of high deformation and M7+ earthquakes of mostly thrust type with some dextral strike-slip faulting observed, too. The Pamir interior shows sinistral strike-slip and normal faulting indicating north-south compression and east-west extension. In this tectonic setting the two largest instrumentally recorded earthquakes, the M7+ 1911 and 2015 earthquake events in the central Pamir occurred with left-lateral shear along a NE-SW rupture plane. We present the co-seismic deformation field of the 2015 earthquake observed by radar satellite interferometry (InSAR), SAR amplitude pixel offsets and high-rate Global Positioning System (GPS). The InSAR and pixel offset results suggest a 50+ km long rupture with sinistral fault offsets at the surface of more than 2 m on a yet unmapped fault trace of the Sarez Karakul Fault System (SKFS). A distributed slip model with a data-driven slip patch resolution yields a sub-vertical fault plane with a strike of N39.5 degrees and a rupture area of ˜80 x 40 km with a maximum slip of 2 m in the upper 10 km of the crust near the surface rupture. Field observations collected some nine months after the earthquake confirm the rupture mechanism, surface trace location and fault offset measurements as constrained by geodetic data. Diffuse deformation was observed across a 1-2 km wide zone, hosting primary fractures sub-parallel to the rupture strike with offsets of 2 m and secondary, en echelon fractures including Riedel shears and hybrid fractures often related to gravitational mass movements. The 1911 and 2015 earthquakes demonstrate the importance of sinistral strike-slip faulting on the SKFS, contributing both to shear between the

  16. Rupture model of the 2015 M7.2 Sarez, Central Pamir, earthquake and the importance of strike-slip faulting in the Pamir interior (United States)

    Metzger, S.; Schurr, B.; Schoene, T.; Zhang, Y.; Sudhaus, H.


    The Pamir mountain range, located in the Northwest of the India-Asia collision zone, accommodates approximately one third of the northward advance of the Indian continent at this longitude (i.e. 34 mm/yr) mostly by shortening at its northern thrust system. Geodetic and seismic data sets reveal here a narrow zone of high deformation and M7+ earthquakes of mostly thrust type with some dextral strike-slip faulting observed, too. The Pamir interior shows sinistral strike-slip and normal faulting indicating north-south compression and east-west extension. In this tectonic setting the two largest instrumentally recorded earthquakes, the M7+ 1911 and 2015 earthquake events in the central Pamir occurred with left-lateral shear along a NE-SW rupture plane. We present the co-seismic deformation field of the 2015 earthquake observed by Radar satellite interferometry (InSAR), SAR amplitude offsets and high-rate Global Positioning System (GPS). The InSAR and offset results reveal that the earthquake created a 50 km long surface rupture with maximum left-lateral offsets of more than two meters on a yet unmapped fault trace of the Sarez Karakul Fault System (SKFS). We further derive a distributed slip-model including a thorough model parameter uncertainty study. Using a two-step approach to first find the optimal rupture geometry and then invert for slip on discrete patches, we show that a data-driven patch resolution produces yields a better representation of the near-surface slip and an increased slip precision than a uniform patch approach without increasing the number of parameters and thus calculation time. Our best-fit model yields a sub-vertical fault plane with a strike of N39.5 degrees and a rupture area of 80 x 40 km2 with a maximum slip of 2 meters in the upper 10 km of the crust near the surface rupture. The 1911 and 2015 earthquakes demonstrate the importance of sinistral strike-slip faulting on the SKFS, contributing both to shear between the western and eastern

  17. Case study of a magnetic transient in NOAA 11429 observed by SDO/HMI during the M7.9 flare on 2012 march 13

    International Nuclear Information System (INIS)

    Harker, Brian J.; Pevtsov, Alexei A.


    NOAA 11429 was the source of an M7.9 X-ray flare at the western solar limb (N18° W63°) on 2012 March 13 at 17:12 UT. Observations of the line-of-sight magnetic flux and the Stokes I and V profiles from which it is derived were carried out by the Solar Dynamics Observatory Helioseismic and Magnetic Imager (SDO/HMI) with a 45 s cadence over the full disk, at a spatial sampling of 0.''5. During flare onset, a transient patch of negative flux can be observed in SDO/HMI magnetograms to rapidly appear within the positive polarity penumbra of NOAA 11429. We present here a detailed study of this magnetic transient and offer interpretations as to whether this highly debated phenomenon represents a 'real' change in the structure of the magnetic field at the site of the flare, or is instead a product of instrumental/algorithmic artifacts related to particular SDO/HMI data reduction techniques.

  18. Mapping of the surface rupture induced by the M 7.3 Kumamoto Earthquake along the Eastern segment of Futagawa fault using image correlation techniques (United States)

    Ekhtari, N.; Glennie, C. L.; Fielding, E. J.; Liang, C.


    Near field surface deformation is vital to understanding the shallow fault physics of earthquakes but near-field deformation measurements are often sparse or not reliable. In this study, we use the Co-seismic Image Correlation (COSI-Corr) technique to map the near-field surface deformation caused by the M 7.3 April 16, 2016 Kumamoto Earthquake, Kyushu, Japan. The surface rupture around the Eastern segment of Futagawa fault is mapped using a pair of panchromatic 1.5 meter resolution SPOT 7 images. These images were acquired on January 16 and April 29, 2016 (3 months before and 13 days after the earthquake respectively) with close to nadir (less than 1.5 degree off nadir) viewing angle. The two images are ortho-rectified using SRTM Digital Elevation Model and further co-registered using tie points far away from the rupture field. Then the COSI-Corr technique is utilized to produce an estimated surface displacement map, and a horizontal displacement vector field is calculated which supplies a seamless estimate of near field displacement measurements along the Eastern segment of the Futagawa fault. The COSI-Corr estimated displacements are then compared to other existing displacement observations from InSAR, GPS and field observations.

  19. Effect of multiple short highly energetic X-ray pulses on the synthesis of endoglucanase by a mutant strain of Trichoderma reesei-M7

    International Nuclear Information System (INIS)

    Gemishev, Orlin; Markova, Maya; Savov, Valentin; Zapryanov, Stanislav; Blagoev, Alexander


    Bioconversion of cellulose-containing substrate to glucose represents an important area of modern biotechnology. Enzymes for the degradation of the polysaccharide part of biomass have been produced, mostly by fungi belonging to genus Trichoderma. Studies were carried out with the mutant strain Trichoderma reesei-M7, a cellulase producer. Spores of the enzyme producer were irradiated with different doses of characteristic X-ray radiation from metallic tungsten (mainly the W Ka1 and Ka2 lines) with a high dose rate. The latter is a specific property of the dense plasma focus (DPF) device, which has pulsed operation and thus gives short and highly energetic pulses of multiple types of rays and particles. In this case, we focused our study on the influence of hard X-rays. The doses of X-rays absorbed by the spores varied in the range of approximately 5-11,000 mSv measured with thermoluminescent dosimeters (TLD). The influence of the applied doses in combination with exceptionally high dose rates (in the order of tens of millisieverts per microsecond) on the activity of the produced endoglucanase, amount of biomass and extra-cellular protein, was studied in batch cultivation conditions. In the dose range of 200-1200 mSv, some enhancement of endoglucanase activity was obtained: around 18%-32%, despite the drop of the biomass amount, compared with the untreated material. Keywords: endoglucanase; X-ray pulses; thermoluminescent dosimeters (TLD); dense plasma focus (DPF); Trichoderma reesei


    Energy Technology Data Exchange (ETDEWEB)

    Liu Wei [Lockheed Martin Solar and Astrophysics Laboratory, Building 252, 3251 Hanover Street, Palo Alto, CA 94304 (United States); Chen Qingrong; Petrosian, Vahe [Department of Physics, Stanford University, Stanford, CA 94305 (United States)


    Where particle acceleration and plasma heating take place in relation to magnetic reconnection is a fundamental question for solar flares. We report analysis of an M7.7 flare on 2012 July 19 observed by SDO/AIA and RHESSI. Bi-directional outflows in forms of plasmoid ejections and contracting cusp-shaped loops originate between an erupting flux rope and underlying flare loops at speeds of typically 200-300 km s{sup -1} up to 1050 km s{sup -1}. These outflows are associated with spatially separated double coronal X-ray sources with centroid separation decreasing with energy. The highest temperature is located near the nonthermal X-ray loop-top source well below the original heights of contracting cusps near the inferred reconnection site. These observations suggest that the primary loci of particle acceleration and plasma heating are in the reconnection outflow regions, rather than the reconnection site itself. In addition, there is an initial ascent of the X-ray and EUV loop-top source prior to its recently recognized descent, which we ascribe to the interplay among multiple processes including the upward development of reconnection and the downward contractions of reconnected loops. The impulsive phase onset is delayed by 10 minutes from the start of the descent, but coincides with the rapid speed increases of the upward plasmoids, the individual loop shrinkages, and the overall loop-top descent, suggestive of an intimate relation of the energy release rate and reconnection outflow speed.

  1. Anomalous Streamflow and Groundwater-Level Changes Before the 1999 M7.6 Chi-Chi Earthquake in Taiwan: Possible Mechanisms (United States)

    King, Chi-Yu; Chia, Yeeping


    Streamflow recorded by a stream gauge located 4 km from the epicenter of the 1999 M7.6 Chi-Chi earthquake in central Taiwan showed a large and rapid anomalous increase of 124 m3/s starting 4 days before the earthquake. This increase was followed by a comparable co-seismic drop to below the background level for 8 months. In addition, groundwater-levels recorded at a well 1.5 km east of the seismogenic fault showed an anomalous rise 2 days before the earthquake, and then a unique 4-cm drop beginning 3 h before the earthquake. The anomalous streamflow increase is attributed to gravity-driven groundwater discharge into the creek through the openings of existing fractures in the steep creek banks crossed by the upstream Shueilikun fault zone, as a result of pre-earthquake crustal buckling. The continued tectonic movement and buckling, together with the downward flow of water in the crust, may have triggered the occurrence of some shallow slow-slip events in the Shueilikun and other nearby fault zones. When these events propagate down-dip to decollement, where the faults merges with the seismogenic Chelungpu fault, they may have triggered other slow-slip events propagating toward the asperity at the hypocenter and the Chelungpu fault. These events may then have caused the observed groundwater-level anomaly and helped to trigger the earthquake.

  2. Implications for stress changes along the Motagua fault and other nearby faults using GPS and seismic constraints on the M=7.3 2009 Swan Islands earthquake (United States)

    Graham, S. E.; Rodriguez, M.; Rogers, R. D.; Strauch, W.; Hernandez, D.; Demets, C.


    The May 28, 2009 M=7.3 Swan Islands earthquake off the north coast of Honduras caused significant damage in the northern part of the country, including seven deaths. This event, the largest in the region for several decades, ruptured the offshore continuation of the Motagua-Polochic fault system, whose 1976 earthquake (located several hundred kilometers to the southwest of the 2009 epicenter) caused more than 23,000 deaths in Central America and left homeless 20% of Guatemala’s population. We use elastic half-space modeling of coseismic offsets measured at 39 GPS stations in Honduras, El Salvador, and Guatemala to better understand the slip source of the recent Swan Islands earthquake. Measured offsets range from .32 meters at a campaign site near the Motagua fault in northern Honduras to 4 millimeters at five continuous sites in El Salvador. Coulomb stress calculations based on the estimated distribution of coseismic slip will be presented and compared to earthquake focal mechanisms and aftershock locations determined from a portable seismic network that was installed in northern Honduras after the main shock. Implications of the Swan Islands rupture for the seismically hazardous Motagua-Polochic fault system will be described.

  3. GPS and seismic constraints on the M = 7.3 2009 Swan Islands earthquake: implications for stress changes along the Motagua fault and other nearby faults (United States)

    Graham, Shannon E.; DeMets, Charles; DeShon, Heather R.; Rogers, Robert; Maradiaga, Manuel Rodriguez; Strauch, Wilfried; Wiese, Klaus; Hernandez, Douglas


    We use measurements at 35 GPS stations in northern Central America and 25 seismometers at teleseismic distances to estimate the distribution of slip, source time function and Coulomb stress changes of the Mw = 7.3 2009 May 28, Swan Islands fault earthquake. This event, the largest in the region for several decades, ruptured the offshore continuation of the seismically hazardous Motagua fault of Guatemala, the site of the destructive Ms = 7.5 earthquake in 1976. Measured GPS offsets range from 308 millimetres at a campaign site in northern Honduras to 6 millimetres at five continuous sites in El Salvador. Separate inversions of geodetic and seismic data both indicate that up to ˜1 m of coseismic slip occurred along a ˜250-km-long rupture zone between the island of Roatan and the eastern limit of the 1976 M = 7.5 Motagua fault earthquake in Guatemala. Evidence for slip ˜250 km west of the epicentre is corroborated independently by aftershocks recorded by a local seismic network and by the high concentration of damage to structures in areas of northern Honduras adjacent to the western limit of the rupture zone. Coulomb stresses determined from the coseismic slip distribution resolve a maximum of 1 bar of stress transferred to the seismically hazardous Motagua fault and further indicate unclamping of normal faults along the northern shore of Honduras, where two M > 5 normal-faulting earthquakes and numerous small earthquakes were triggered by the main shock.

  4. Modelling macroseismic observations for historical earthquakes: the cases of the M = 7.0, 1954 Sofades and M = 6.8, 1957 Velestino events (central Greece) (United States)

    Papazachos, Giannis; Papazachos, Costas; Skarlatoudis, Andreas; Kkallas, Harris; Lekkas, Efthimios


    We attempt to model the spatial distribution of the strong ground motion for the large M = 7.0, 1954 Sofades and M = 6.8, 1957 Velestino events (southern Thessaly basin, central Greece), using the macroseismic intensities ( I M M up to 9+) observed within the broader Thessaly area. For this reason, we employ a modified stochastic method realised by the EXSIM algorithm for extended sources, in order to reproduce the damage distribution of these earthquakes, in an attempt to combine existing earthquake information and appropriate scaling relations with surface geology and to investigate the efficiency of the available macroseismic data. For site-effects assessment, we use a new digital geological map of the broader Thessaly basin, where geological formations are grouped by age and mapped on appropriate NEHRP soil classes. Using the previous approach, we estimate synthetic time series for different rupture scenarios and employ various calibrating relations between PGA/PGV and macroseismic intensity, allowing the generation of synthetic (stochastic) isoseismals. Also, different site amplification factors proposed for the broader Aegean area, according to local geology, are tested. Finally, we also perform a sensitivity analysis of the fault location, taking into account the available neotectonic data for the broader southern Thessaly fault zone. The finally determined fault locations are different than previously proposed, in agreement with the available neotectonic information. The observed macroseismic intensities are in good agreement with the ones derived from the synthetic waveforms, verifying both the usefulness of the approach, as well as of the macroseismic data used. Finally, site-effects show clear correlation with the geological classification employed, with constant amplification factors for each soil class generally providing better results than generic transfer functions.

  5. Imaging the Shallow Crust in the Epicentral Area of the 1857 M7 Agri Valley Earthquake (Southern Italy) by Combined Traveltime and Full-Waveform Tomography (United States)

    Improta, L.; Operto, S.; Piromallo, C.; Valoroso, L.


    The Agri Valley is a Quaternary extensional basin located in the Southern Apennines range. This basin was struck by a M7 earthquake in 1857. In spite of extensive morphotectonic surveys and hydrocarbon exploration, major unsolved questions remain about the upper crustal structure, the recent tectonic evolution and seismotectonics of the area. Most authors consider a SW-dipping normal-fault system bordering the basin to the East as the major seismogenic source. Alternatively, some authors ascribe the high seismogenic potential of the region to NE-dipping normal faults identified by morphotectonic surveys along the ridge bounding the basin to the West. These uncertainties mainly derive from the poor performance of commercial reflection profiling that suffers from an extreme structural complexity and unfavorable near-surface conditions. To overcome these drawbacks, ENI and Shell Italia carried out a non-conventional wide-aperture survey with densely spaced sources (60 m) and receivers (90 m). The 18-km-long wide-aperture profile crosses the basin, yielding a unique opportunity to get new insights into the crustal structure by using advanced imaging techniques. Here, we apply a two-step imaging procedure. We start determining multi- scale Vp images down to 2.5 km depth by using a non-linear traveltime tomographic technique able to cope with strongly heterogeneous media. Assessment of an accurate reference Vp model is indeed crucial for the subsequent application of a frequency-domain full-waveform inversion aimed at improving spatial resolution of the velocity images. Frequency components of the data are then iteratively inverted from low to high frequency values in order to progressively incorporate smaller wavelength components into the model. Inversion results accurately image the shallow crust, yielding valuable constraints for a better understanding of the recent basin evolution and of the surrounding normal-fault systems.

  6. Using structural damage statistics to derive macroseismic intensity within the Kathmandu valley for the 2015 M7.8 Gorkha, Nepal earthquake (United States)

    McGowan, S. M.; Jaiswal, K. S.; Wald, D. J.


    We make and analyze structural damage observations from within the Kathmandu valley following the 2015 M7.8 Gorkha, Nepal earthquake to derive macroseismic intensities at several locations including some located near ground motion recording sites. The macroseismic intensity estimates supplement the limited strong ground motion data in order to characterize the damage statistics. This augmentation allows for direct comparisons between ground motion amplitudes and structural damage characteristics and ultimately produces a more constrained ground shaking hazard map for the Gorkha earthquake. For systematic assessments, we focused on damage to three specific building categories: (a) low/mid-rise reinforced concrete frames with infill brick walls, (b) unreinforced brick masonry bearing walls with reinforced concrete slabs, and (c) unreinforced brick masonry bearing walls with partial timber framing. Evaluating dozens of photos of each construction type, assigning each building in the study sample to a European Macroseismic Scale (EMS)-98 Vulnerability Class based upon its structural characteristics, and then individually assigning an EMS-98 Damage Grade to each building allows a statistically derived estimate of macroseismic intensity for each of nine study areas in and around the Kathmandu valley. This analysis concludes that EMS-98 macroseismic intensities for the study areas from the Gorkha mainshock typically were in the VII-IX range. The intensity assignment process described is more rigorous than the informal approach of assigning intensities based upon anecdotal media or first-person accounts of felt-reports, shaking, and their interpretation of damage. Detailed EMS-98 macroseismic assessments in urban areas are critical for quantifying relations between shaking and damage as well as for calibrating loss estimates. We show that the macroseismic assignments made herein result in fatality estimates consistent with the overall and district-wide reported values.

  7. Shear wave velocity investigation of soil liquefaction sites from the Tangshan, China M7.8 earthquake of 1976 using active and passive surface wave methods (United States)

    Kayen, Robert E; Tao, Xiaxin; Shi, Lijing; Shi, Hailiang


    An initial investigation of soil liquefaction sites from the July, 28 1976 Tangshan M7.8 earthquake was conducted between 1976 and 1978 by the National Ministry of Railways, China. These data are the basis of the ‘Chinese Method’ for assessment of liquefaction potential of silty-sand deposits, and are an important component of the worldwide data set for modern probabilistic methods for assessment of soil liquefaction using Bayesian updating and system reliability tools. We revisited 26 sites identified in the maps and published 198 report of the Ministry of Railways in order to investigate these locations with a suite of active- and passive-array surface wave methods. These sites are clustered along the north coast of the Bo Hai Sea in three areas: Lutai, Tianjin; Tangshan City and outlying village, Hebei; and Luannan county, Hebei. First, we gathered and evaluated the Rayleigh wave dispersion characteristics of the ground by comparing dispersion curves from the active source harmonic wave-spectral analysis of surface waves (SASW) method and the passive array Spatial Auto-Correlation method (SPAC). The dispersive properties of the liquefied ground as measured by these two methods were found to be almost identical. These tests were hybridized and the data sets merged in order to invert of shear wave velocities for analysis of liquefaction potential using a probabilistic framework. The data from high-values of seismic intensity near Tangshan city to low-intensities distant of the event in Luannan County segregate out into clusters of liquefied and non liquefied points clearly separated by liquefaction boundary curves developed from a large global data set of 310 sites

  8. Transient stresses al Parkfield, California, produced by the M 7.4 Landers earthquake of June 28, 1992: implications for the time-dependence of fault friction

    Directory of Open Access Journals (Sweden)

    J. B. Fletcher


    Full Text Available he M 7.4 Landers earthquake triggered widespread seismicity in the Western U.S. Because the transient dynamic stresses induced at regional distances by the Landers surface waves are much larger than the expected static stresses, the magnitude and the characteristics of the dynamic stresses may bear upon the earthquake triggering mechanism. The Landers earthquake was recorded on the UPSAR array, a group of 14 triaxial accelerometers located within a 1-square-km region 10 km southwest of the town of Parkfield, California, 412 km northwest of the Landers epicenter. We used a standard geodetic inversion procedure to determine the surface strain and stress tensors as functions of time from the observed dynamic displacements. Peak dynamic strains and stresses at the Earth's surface are about 7 microstrain and 0.035 MPa, respectively, and they have a flat amplitude spectrum between 2 s and 15 s period. These stresses agree well with stresses predicted from a simple rule of thumb based upon the ground velocity spectrum observed at a single station. Peak stresses ranged from about 0.035 MPa at the surface to about 0.12 MPa between 2 and 14 km depth, with the sharp increase of stress away from the surface resulting from the rapid increase of rigidity with depth and from the influence of surface wave mode shapes. Comparison of Landers-induced static and dynamic stresses at the hypocenter of the Big Bear aftershock provides a clear example that faults are stronger on time scales of tens of seconds than on time scales of hours or longer.

  9. MELCOR 1.8.3 application to NUPEC M-7-1 test (ISP-35) and two hydrogen severe accident scenarios in a typical PWR plant

    International Nuclear Information System (INIS)

    Jimenez Garcia, M.A.; Martin-Fuertes, F.; Martin-Valdepenas, J.M.


    Combustion of the hydrogen released to the containment during a severe accident is one of the issues to establish the real threats to the third barrier integrity in nuclear power facilities. Computational efforts on management procedures, such as the containment spray operation, are being addressed at the CTN-UPM to cope with the problem. On top of this, studies about in-containment hydrogen distribution and combustion are currently carried out with the codes MELCOR 1.8.3 and ESTER 1.0-RALOC 2.2. In this study, MELCOR 1.8.3 has been validated against the NUPEC M-7-1 Test, which already showed in 1993 that a good agreement was reached out when the previous MELCOR 1.8.2 calculations were performed regarding to the helium distribution throughout the facility. Nevertheless, some discrepancies were detected when analysing wall and atmosphere temperatures. Generally, well-mixed atmosphere scenarios, in which the role played by the containment water spraying is of the major importance, appear when such a mechanism promotes the onset of convection driven flow patterns that rapidly homogenize the gas properties. The purpose of the new MELCOR 1.8.3 assessment is to take advantage of the newest implemented models to obtain a more realistic thermalhydraulics simulation. A variation case was also performed to highlight the influence of water spray operation. In a second part of the study, insights coming from the previous work were used to apply MELCOR 1.8.3 models to a SBO severe accident scenario management in a commercial 2700 MWt 3-loop W PWR containment

  10. Ground motion attenuation during M 7.1 Darfield and M 6.2 Christchurch, New Zealand, earthquakes and performance of global Ppedictive models (United States)

    Segou, Margaret; Kalkan, Erol


    The M 7.1 Darfield earthquake occurred 40 km west of Christchurch (New Zealand) on 4 September 2010. Six months after, the city was struck again with an M 6.2 event on 22 February local time (21 February UTC). These events resulted in significant damage to infrastructure in the city and its suburbs. The purpose of this study is to evaluate the performance of global predictive models (GMPEs) using the strong motion data obtained from these two events to improve future seismic hazard assessment and building code provisions for the Canterbury region.The Canterbury region is located on the boundary between the Pacific and Australian plates; its surface expression is the active right lateral Alpine fault (Berryman et al. 1993). Beneath the North Island and the north South Island, the Pacific plate subducts obliquely under the Australian plate, while at the southwestern part of the South Island, a reverse process takes place. Although New Zealand has experienced several major earthquakes in the past as a result of its complex seismotectonic environment (e.g., M 7.1 1888 North Canterbury, M 7.0 1929 Arthur's Pass, and M 6.2 1995 Cass), there was no evidence of prior seismic activity in Christchurch and its surroundings before the September event. The Darfield and Christchurch earthquakes occurred along the previously unmapped Greendale fault in the Canterbury basin, which is covered by Quaternary alluvial deposits (Forsyth et al. 2008). In Figure 1, site conditions of the Canterbury epicentral area are depicted on a VS30 map. This map was determined on the basis of topographic slope calculated from a 1-km grid using the method of Allen and Wald (2007). Also shown are the locations of strong motion stations.The Darfield event was generated as a result of a complex rupture mechanism; the recordings and geodetic data reveal that earthquake consists of three sub-events (Barnhart et al. 2011, page 815 of this issue). The first event was due to rupturing of a blind reverse

  11. A physical model of the Mexico City seismic response after the damaging M7.1 earthquake of September 19, 2017 (United States)

    Cruz-Atienza, V. M.; Tago, J.; Villafuerte, C. D.; Chaljub, E.; Sanabria-Gómez, J. D.


    Built-up on top of ancient lake deposits, Mexico City experiences some of the largest seismic site effects in the world. The M7.1 intermediate-depth earthquake of September 19, 2017 (S19) collapsed 43 one-to-ten story buildings in the city close to the western edge of the lake-bed sediments, on top of the geotechnically-known transition zone. In this work we explore the physical reasons explaining such a damaging pattern and the long-lasting strong motion records well-documented from past events by means of new observations and high performance computational modeling. Besides the extreme amplification of seismic waves, duration of intense ground motion in the lake-bed lasts more than three times those recorded in hard-rock a few kilometers away. Different mechanisms contribute to the long lasting motions, such as the regional dispersion and multiple-scattering of the incoming wavefield all the way from the source. However, recent beamforming observations at hard-rock suggest that duration of the incoming field is significantly shorter than the strong shaking in the lake-bed. We show that despite the highly dissipative shallow deposits, seismic energy can propagate long distances in the deep structure of the valley, promoting also a large elongation of motion. Our simulations reveal that the seismic response of the basin is dominated by surface-waves overtones, and that this mechanism increases the duration of ground motion up to 280% and 500% of the incoming wavefield duration at 0.5 and 0.3 Hz, respectively. Furthermore, our results indicate that the damage pattern of the S19 earthquake is most likely due to the propagation of the fundamental mode in the transition zone of the basin. These conclusions contradicts what has been previously stated from observational and modeling investigations, where the basin itself has been discarded as a preponderant factor promoting long and devastating shaking in Mexico City. Reference: Cruz-Atienza, V. M., J. Tago, J. D

  12. Fault- and Area-Based PSHA in Nepal using OpenQuake: New Insights from the 2015 M7.8 Gorkha-Nepal Earthquake (United States)

    Stevens, Victoria


    The 2015 Gorkha-Nepal M7.8 earthquake (hereafter known simply as the Gorkha earthquake) highlights the seismic risk in Nepal, allows better characterization of the geometry of the Main Himalayan Thrust (MHT), and enables comparison of recorded ground-motions with predicted ground-motions. These new data, together with recent paleoseismic studies and geodetic-based coupling models, allow for good parameterization of the fault characteristics. Other faults in Nepal remain less well studied. Unlike previous PSHA studies in Nepal that are exclusively area-based, we use a mix of faults and areas to describe six seismic sources in Nepal. For each source, the Gutenberg-Richter a and b values are found, and the maximum magnitude earthquake estimated, using a combination of earthquake catalogs, moment conservation principals and similarities to other tectonic regions. The MHT and Karakoram fault are described as fault sources, whereas four other sources - normal faulting in N-S trending grabens of northern Nepal, strike-slip faulting in both eastern and western Nepal, and background seismicity - are described as area sources. We use OpenQuake ( to carry out the analysis, and peak ground acceleration (PGA) at 2 and 10% chance in 50 years is found for Nepal, along with hazard curves at various locations. We compare this PSHA model with previous area-based models of Nepal. The Main Himalayan Thrust is the principal seismic hazard in Nepal so we study the effects of changing several parameters associated with this fault. We compare ground shaking predicted from various fault geometries suggested from the Gorkha earthquake with each other, and with a simple model of a flat fault. We also show the results from incorporating a coupling model based on geodetic data and microseismicity, which limits the down-dip extent of rupture. There have been no ground-motion prediction equations (GMPEs) developed specifically for Nepal, so we compare the results of

  13. Broad-band simulation of M7.2 earthquake on the North Tehran fault, considering non-linear soil effects (United States)

    Majidinejad, A.; Zafarani, H.; Vahdani, S.


    The North Tehran fault (NTF) is known to be one of the most drastic sources of seismic hazard on the city of Tehran. In this study, we provide broad-band (0-10 Hz) ground motions for the city as a consequence of probable M7.2 earthquake on the NTF. Low-frequency motions (0-2 Hz) are provided from spectral element dynamic simulation of 17 scenario models. High-frequency (2-10 Hz) motions are calculated with a physics-based method based on S-to-S backscattering theory. Broad-band ground motions at the bedrock level show amplifications, both at low and high frequencies, due to the existence of deep Tehran basin in the vicinity of the NTF. By employing soil profiles obtained from regional studies, effect of shallow soil layers on broad-band ground motions is investigated by both linear and non-linear analyses. While linear soil response overestimate ground motion prediction equations, non-linear response predicts plausible results within one standard deviation of empirical relationships. Average Peak Ground Accelerations (PGAs) at the northern, central and southern parts of the city are estimated about 0.93, 0.59 and 0.4 g, respectively. Increased damping caused by non-linear soil behaviour, reduces the soil linear responses considerably, in particular at frequencies above 3 Hz. Non-linear deamplification reduces linear spectral accelerations up to 63 per cent at stations above soft thick sediments. By performing more general analyses, which exclude source-to-site effects on stations, a correction function is proposed for typical site classes of Tehran. Parameters for the function which reduces linear soil response in order to take into account non-linear soil deamplification are provided for various frequencies in the range of engineering interest. In addition to fully non-linear analyses, equivalent-linear calculations were also conducted which their comparison revealed appropriateness of the method for large peaks and low frequencies, but its shortage for small to

  14. Geomorphic Evidence of a Complex late-Cenozoic Uplift and Lateral Displacement History Along the 2013 M7.7 Baluchistan, Pakistan Strike-slip Rupture (United States)

    Harbor, D. J.; Barnhart, W. D.


    The 2013 M7.7 Baluchistan earthquake in southern Pakistan ruptured 200 km of the north-dipping Hoshab reverse fault with dominantly lateral motion, clearly at odds with the regional topography created by previous reverse fault offsets. The kinematics of this earthquake led to the hypotheses that the Hoshab fault may alternatively slip in a reverse and lateral sense (bi-modal slip), and that the southeast Makran rotates as a uniform block around the fault (ball-and-socket rotation). Here, we use river profiles, regional relief, fault locations, and detailed geomorphic maps derived from optical imagery and DEMs to evaluate the recent uplift history of this region. We find that late Cenozoic fault zone geomorphology supports a spatially complex transition from lateral-dominated offsets in the NE to reverse-dominated offsets in the SW. Additionally, fault zone geomorphology suggests that the location of the Hoshab fault itself may change through time, leading to active incision of footwall alluvial fans and pediments. Stream profiles likewise record incision patterns that vary along the Hoshab fault. Incision and deposition in the SW are illustrative of relative footwall subsidence, consistent with recent uplift on the Hoshab fault; whereas incision and deposition in the NE are illustrative of relative footwall uplift consistent with ongoing regional uplift due to ball-and-socket rotations and dominantly lateral offsets along the northern Hoshab fault. The largest streams also record multiple, discrete, base-level drops, including the presence of convex-up river profiles in the hanging wall of the Hoshab fault. These profiles along hanging wall streams highlight a complex spatial and temporal history of reverse offset, lateral channel offset, and base-level resetting in regional streams that are altogether inconsistent with the kinematics of the 2013 earthquake alone, but that are consistent with the bi-modal slip model. Additionally, the evidence of footwall uplift in

  15. Rapid Seismic Deployment for Capturing Aftershocks of the September 2017 Tehuantepec, Mexico (M=8.1) and Morelos-Puebla (M=7.1), Mexico Earthquakes (United States)

    Velasco, A. A.; Karplus, M. S.; Dena, O.; Gonzalez-Huizar, H.; Husker, A. L.; Perez-Campos, X.; Calo, M.; Valdes, C. M.


    The September 7 Tehuantepec, Mexico (M=8.1) and the September 19 Morelos-Puebla, Mexico (M=7.1) earthquakes ruptured with extensional faulting within the Cocos Plate at 70-km and 50-km depth, as it subducts beneath the continental North American Plate. Both earthquakes caused significant damage and loss of life. These events were followed by a M=6.1 extensional earthquake at only 10-km depth in Oaxaca on September 23, 2017. While the Morelos-Puebla earthquake was likely too far away to be statically triggered by the Tehuantepec earthquake, initial Coulomb stress analyses show that the M=6.1 event may have been an aftershock of the Tehuantepec earthquake. Many questions remain about these earthquakes, including: Did the Cocos Plate earthquakes load the upper plate, and could they possibly trigger an equal or larger earthquake on the plate interface? Are these the result of plate bending? Do the aftershocks migrate to the locked zone in the subduction zone? Why did the intermediate depth earthquakes create so much damage? Are these earthquakes linked by dynamic stresses? Is it possible that a potential slow-slip event triggered both events? To address some of these questions, we deployed 10 broadband seismometers near the epicenter of the Tehuantepec, Mexico earthquake and 51 UTEP-owned nodes (5-Hz, 3-component geophones) to record aftershocks and augment networks deployed by the Universidad Nacional Autónoma de México (UNAM). The 10 broadband instruments will be deployed for 6 months, while the nodes were deployed 25 days. The relative ease-of-deployment and larger numbers of the nodes allowed us to deploy them quickly in the area near the M=6.1 Oaxaca earthquake, just a few days after that earthquake struck. We deployed them near the heavily-damaged cities of Juchitan, Ixtaltepec, and Ixtepec as well as in Tehuantepec and Salina Cruz, Oaxaca in order to test their capabilities for site characterization and aftershock studies. This is the first test of these

  16. Earthquake source imaging by high-resolution array analysis at regional distances: the 2010 M7 Haiti earthquake as seen by the Venezuela National Seismic Network (United States)

    Meng, L.; Ampuero, J. P.; Rendon, H.


    Back projection of teleseismic waves based on array processing has become a popular technique for earthquake source imaging,in particular to track the areas of the source that generate the strongest high frequency radiation. The technique has been previously applied to study the rupture process of the Sumatra earthquake and the supershear rupture of the Kunlun earthquakes. Here we attempt to image the Haiti earthquake using the data recorded by Venezuela National Seismic Network (VNSN). The network is composed of 22 broad-band stations with an East-West oriented geometry, and is located approximately 10 degrees away from Haiti in the perpendicular direction to the Enriquillo fault strike. This is the first opportunity to exploit the privileged position of the VNSN to study large earthquake ruptures in the Caribbean region. This is also a great opportunity to explore the back projection scheme of the crustal Pn phase at regional distances,which provides unique complementary insights to the teleseismic source inversions. The challenge in the analysis of the 2010 M7.0 Haiti earthquake is its very compact source region, possibly shorter than 30km, which is below the resolution limit of standard back projection techniques based on beamforming. Results of back projection analysis using the teleseismic USarray data reveal little details of the rupture process. To overcome the classical resolution limit we explored the Multiple Signal Classification method (MUSIC), a high-resolution array processing technique based on the signal-noise orthognality in the eigen space of the data covariance, which achieves both enhanced resolution and better ability to resolve closely spaced sources. We experiment with various synthetic earthquake scenarios to test the resolution. We find that MUSIC provides at least 3 times higher resolution than beamforming. We also study the inherent bias due to the interferences of coherent Green’s functions, which leads to a potential quantification

  17. Comparison of the Structurally Controlled Landslides Numerical Model Results to the M 7.2 2013 Bohol Earthquake Co-seismic Landslides (United States)

    Macario Galang, Jan Albert; Narod Eco, Rodrigo; Mahar Francisco Lagmay, Alfredo


    The M 7.2 October 15, 2013 Bohol earthquake is the most destructive earthquake to hit the Philippines since 2012. The epicenter was located in Sagbayan municipality, central Bohol and was generated by a previously unmapped reverse fault called the "Inabanga Fault". Its name, taken after the barangay (village) where the fault is best exposed and was first seen. The earthquake resulted in 209 fatalities and over 57 billion USD worth of damages. The earthquake generated co-seismic landslides most of which were related to fault structures. Unlike rainfall induced landslides, the trigger for co-seismic landslides happen without warning. Preparedness against this type of landslide therefore, relies heavily on the identification of fracture-related unstable slopes. To mitigate the impacts of co-seismic landslide hazards, morpho-structural orientations or discontinuity sets were mapped in the field with the aid of a 2012 IFSAR Digital Terrain Model (DTM) with 5-meter pixel resolution and software was then used to identify similar structures including measurement of their dip and dip directions. The chosen discontinuity sets were then keyed into Matterocking software to identify potential rock slide zones due to planar or wedged discontinuities. After identifying the structurally-controlled unstable slopes, the rock mass propagation extent of the possible rock slides was simulated using Conefall. The results were compared to a post-earthquake landslide inventory of 456 landslides. Out the total number of landslides identified from post-earthquake high-resolution imagery, 366 or 80% intersect the structural-controlled hazard areas of Bohol. The results show the potential of this method to identify co-seismic landslide hazard areas for disaster mitigation. Along with computer methods to simulate shallow landslides, and debris flow paths, located structurally-controlled unstable zones can be used to mark unsafe areas for settlement. The method can be further improved with the

  18. Validation of the OMRON M7 (HEM-780-E) blood pressure measuring device in a population requiring large cuff use according to the International Protocol of the European Society of Hypertension. (United States)

    El Feghali, Ramzi N; Topouchian, Jirar A; Pannier, Bruno M; El Assaad, Hiba A; Asmar, Roland G


    A high percentage of hypertensive patients present an arm circumference of over 32 cm; the use of a large cuff is therefore recommended. Validation studies are usually performed in the general population using a standard-size cuff. The aim of this study was to assess the accuracy of the Omron M7 device in a population with an arm circumference ranging from 32 to 42 cm. A validation study was performed according to the International Protocol of the European Society of Hypertension. This protocol is divided into two phases: the first phase is performed on 15 selected participants (45 pairs of blood-pressure measurements); if the device passes this phase, 18 supplementary participants are included (54 pairs of blood-pressure measurements), making a total number of 33 participants (99 pairs of blood-pressure measurements), on whom the analysis is performed. For each participant, four blood-pressure measurements were performed simultaneously by two trained observers, using mercury sphygmomanometers fitted with a Y tube; the measurements alternated with three by the test device. The difference between the blood-pressure value given by the device and that obtained by the two observers (mean of the two observations) was calculated for each measure. The 99 pairs of blood-pressure differences were classified into three categories (Society of Hypertension protocol. The Omron M7 device passed the first and the second phases of the validation process. The average differences between the two observers were 1.5+/-3.2 and -0.5+/-2.2 mmHg for systolic blood pressure and diastolic blood pressure, and those between the device and the mercury sphygmomanometer were -1.6+/-6.7 for systolic blood pressure and -0.12+/-4.0 mmHg for diastolic blood pressure Readings that differ by less than 5, 10 and 15 mmHg for systolic blood-pressure and diastolic blood-pressure values fulfill the recommendation criteria of the European Society of Hypertension protocol. The Omron M7 (HEM-780-E) device

  19. A Search for Coronal Emission at the Bottom of the Main-Sequence: Stars and Brown Dwarf Candidates with Spectral Types Later than M7 and the Rotation-Activity Relation (United States)

    Stringfellow, Guy


    This program intended to test whether the lowest mass stars at the bottom end of the main sequence and the lower mass brown dwarfs have coronae. If they have coronae, what are the coronal characteristics and what drives them? In the classical dynamo picture, the closed magnetic loop structure is generated near the boundary of the convective envelope and the radiative core. Stars with mass below 0.30 Msun however are fully convective, and the nature of the dynamo responsible for the generation of the coronae in this regime is poorly understood. Previous results from the ROSAT mission (e.g., Fleming et al. 1993, 1995; Schmitt et al. 1995) had confirmed three very important characteristics of M-star coronae: (1) a very high percentage of all M dwarfs have coronae (of order 85% in the local 7 pc sample), (2) those M dwarfs showing high chromospheric activity, such as having the Balmer series in emission or large/numerous optical flaring, indeed exhibit the highest coronal activity, and (3) that the maximum saturation boundary in X-ray luminosity, which amounts to 0.0001-0.001 for Lx/Lbol for the dMe stars, extends down to the current detection limit, through spectral types M7. It was likely that the incompleteness noted for result (1) above was simply a detection limit problem; for more distant sources, the X-ray fainter dM stars will drop below detection thresholds before the more X-ray luminous dMe stars. The latest stars for which direct detection of the corona had been successful were of spectral type dM7 (e.g., VB8, LHS 3003). This program proposed to obtain ROSAT HRI observations for a large number of the coolest known (at that time) stars at the bottom of the main-sequence, which had spectral types of M9 or later. Three stars were approved for observations with ROSAT-HRI totaling 180 ksec. The goal was to obtain X-ray detections or low upper limits for the three approved stars.

  20. Interpretation of earthquake-induced landslides triggered by the 12 May 2008, M7.9 Wenchuan earthquake in the Beichuan area, Sichuan Province, China using satellite imagery and Google Earth (United States)

    Sato, H.P.; Harp, E.L.


    The 12 May 2008 M7.9 Wenchuan earthquake in the People's Republic of China represented a unique opportunity for the international community to use commonly available GIS (Geographic Information System) tools, like Google Earth (GE), to rapidly evaluate and assess landslide hazards triggered by the destructive earthquake and its aftershocks. In order to map earthquake-triggered landslides, we provide details on the applicability and limitations of publicly available 3-day-post- and pre-earthquake imagery provided by GE from the FORMOSAT-2 (formerly ROCSAT-2; Republic of China Satellite 2). We interpreted landslides on the 8-m-resolution FORMOSAT-2 image by GE; as a result, 257 large landslides were mapped with the highest concentration along the Beichuan fault. An estimated density of 0.3 landslides/km2 represents a minimum bound on density given the resolution of available imagery; higher resolution data would have identified more landslides. This is a preliminary study, and further study is needed to understand the landslide characteristics in detail. Although it is best to obtain landslide locations and measurements from satellite imagery having high resolution, it was found that GE is an effective and rapid reconnaissance tool. ?? 2009 Springer-Verlag.

  1. 78 FR 77618 - Airworthiness Directives; M7 Aerospace LLC Airplanes (United States)


    ... the FS 69.31 front pressure bulkhead. The cracks are located in the radii of the left-hand and right-hand part number 27-21027 frames. The cracks were discovered by maintenance personnel after the flight...., Washington, DC 20590. Hand Delivery: Deliver to Mail address above between 9 a.m. and 5 p.m., Monday through...

  2. 76 FR 50881 - Airworthiness Directives; M7 Aerospace LP Airplanes (United States)


    ... interconnect primary control cables, and checking and setting of flight control cable tension. This AD was prompted by a report of a failure of a rudder control cable. We are issuing this AD to correct the unsafe... paragraphs (g)(2) or (h)(1) of this AD, check (set) flight control cable tension. (i) Alternative Methods of...

  3. Code accuracy evaluation of ISP 35 calculations based on NUPEC M-7-1 test

    International Nuclear Information System (INIS)

    Auria, F.D.; Oriolo, F.; Leonardi, M.; Paci, S.


    Quantitative evaluation of code uncertainties is a necessary step in the code assessment process, above all if best-estimate codes are utilised for licensing purposes. Aiming at quantifying the code accuracy, an integral methodology based on the Fast Fourier Transform (FFT) has been developed at the University of Pisa (DCMN) and has been already applied to several calculations related to primary system test analyses. This paper deals with the first application of the FFT based methodology to containment code calculations based on a hydrogen mixing and distribution test performed in the NUPEC (Nuclear Power Engineering Corporation) facility. It is referred to pre-test and post-test calculations submitted for the International Standard Problem (ISP) n. 35. This is a blind exercise, simulating the effects of steam injection and spray behaviour on gas distribution and mixing. The result of the application of this methodology to nineteen selected variables calculated by ten participants are here summarized, and the comparison (where possible) of the accuracy evaluated for the pre-test and for the post-test calculations of a same user is also presented. (author)

  4. Critical evaluation of pressurized microwave-assisted digestion efficiency using nitric acid oxidizing systems (M7)

    International Nuclear Information System (INIS)

    Matusiewicz, H.


    Full text: The possibilities of enhancement of a medium-pressure microwave-assisted digestion system for sample preparation in trace element analysis of biological material was investigated. Based on optimal digestion conditions for oxidizing systems with nitric acid, different digestion procedures were examined to minimize residual carbon. The substitution of nitric acid and the addition of hydrogen peroxide and ozone to nitric acid was evaluated. The residual carbon content of the digestate was determined coulometrically. Addition of hydrogen peroxide during organic oxidation reactions does not lower the resolved carbon in the solution. Ozone was tested as an additional, potentially non-contaminating, digestion/oxidation system to the nitric acid used in the sample preparation method. (author)

  5. M7--a high speed digital processor for second level trigger selections

    International Nuclear Information System (INIS)

    Droege, T.F.; Gaines, I.; Turner, K.J.


    A digital processor is described which reconstructs mass and momentum as a second-level trigger selection. The processor is a five-address, microprogramed, pipelined, ECL machine with simultaneous memory access to four operands which load two parallel multipliers and an ALU. Source data modules are extensions of the processor

  6. Prestate of Stress and Fault Behavior During the 2016 Kumamoto Earthquake (M7.3) (United States)

    Matsumoto, Satoshi; Yamashita, Yusuke; Nakamoto, Manami; Miyazaki, Masahiro; Sakai, Shinichi; Iio, Yoshihisa; Shimizu, Hiroshi; Goto, Kazuhiko; Okada, Tomomi; Ohzono, Mako; Terakawa, Toshiko; Kosuga, Masahiro; Yoshimi, Masayuki; Asano, Youichi


    Fault behavior during an earthquake is controlled by the state of stress on the fault. Complex coseismic fault slip on large earthquake faults has recently been observed by dense seismic networks, which complicates strong motion evaluations for potential faults. Here we show the three-dimensional prestress field related to the 2016 Kumamoto earthquake. The estimated stress field reveals a spatially variable state of stress that forced the fault to slip in a direction predicted by the "Wallace and Bott Hypothesis." The stress field also exposes the pre-condition of pore fluid pressure on the fault. Large coseismic slip occurred in the low-pressure part of the fault. However, areas with highly pressured fluid also showed large displacement, indicating that the seismic moment of the earthquake was magnified by fluid pressure. These prerupture data could contribute to improved seismic hazard evaluations.

  7. Unusually Deep Bonin Earthquake (M7.9) of May 30, 2015 Suggests that Stagnant Slab Transforms into Penetration Stage (United States)

    Obayashi, M.; Fukao, Y.; Yoshimitsu, J.


    A great shock occurred at an unusual depth of 678 km far away from the well-defined Wadati-Benioff zone of the Izu-Bonin arc (Fig.1). To the north of this region the slab is stagnant above the 660 km discontinuity and to the south it penetrates the discontinuity (Fig.2). Thus, the slab in this region can be viewed as in a transitional state from the stagnant to penetrating slab. Here, the steeply dipping part of the slab bends sharply to horizontal and the great shock happened at the lowest corner of this bending. The CMT indicates a pure normal faulting with the trench-normal near horizontal tensional axis and the near vertical compressional axis (Fig.1). We suggest that this mechanism reflects a transitional state of slab deformation from the bending-dominant mode to the penetration-dominant mode. The mechanism is consistent with either of these two two modes. We show that the mechanism is also consistent with the resultant stress field generated by many deep shocks occurring along the Wadati-Benioff zone. The calculated stress field changes rapidly along a trench-normal profile at a depth of 680 km and becomes similar to that generated by the great shock at points near the hypocenter (Fig.3). Thus, the stress field due to the Wadati-Benioff zone earthquakes works to enhance the occurrence of deep shocks of the type of the 2015 great shock, which represents slab deformation associated with the transition from stagnant to penetrating slab.

  8. GPS Time Series Analysis of Southern California Associated with the 2010 M7.2 El Mayor/Cucapah Earthquake (United States)

    Granat, Robert; Donnellan, Andrea


    The Magnitude 7.2 El-Mayor/Cucapah earthquake the occurred in Mexico on April 4, 2012 was well instrumented with continuous GPS stations in California. Large Offsets were observed at the GPS stations as a result of deformation from the earthquake providing information about the co-seismic fault slip as well as fault slip from large aftershocks. Information can also be obtained from the position time series at each station.

  9. Correlation between short-range order, optical properties and UV-absorption ability in tellurate glasses; Poster M7

    Energy Technology Data Exchange (ETDEWEB)

    Burger, H; Tews, W; Vogel, W; Kozhukharov, V [Jena Univ. (Germany)


    Tellurate glasses, with as second components Al[sub 2]O[sub 3], PbO, PbF[sub 2], PbCl[sub 2], PbBr[sub 2], PbSO[sub 4], ZnO, B[sub 2]O[sub 3], P[sub 2]O[sub 5], Li[sub 2]O, Na[sub 2]O, K[sub 2]O, MgO and BaO as well as some glasses from ternary TeO[sub 2]-P[sub 2]O[sub 5]-RO systems (R is Pb, Ba and Zn ions), have been investigated. Transmittance spectra in UV and VIS region of some selected glasses have been measured. A correlation between optical properties and UV absorption edge of the transmittance have been done. Using p[sup 31]-NMR spectroscopy the structural changes on short-range level order are studied. A strong influence on the refraction and dispersion values as well as UV-absorption ability of the glasses is established. For p[sup 31] -NMR spectroscopy investigations of crystalline phosphotellurites and related phosphotellurite glasses the TeO[sub 2]-P[sub 2]O[sub 5B]aO ternary system have been chosen. (author).

  10. Thermal, atmospheric and ionospheric anomalies around the time of the Colima M7.8 earthquake of 21 January 2003

    Directory of Open Access Journals (Sweden)

    S. A. Pulinets


    Full Text Available The paper examines the possible relationship of anomalous variations of different atmospheric and ionospheric parameters observed around the time of a strong earthquake (Mw 7.8 which occurred in Mexico (state of Colima on 21 January 2003. These variations are interpreted within the framework of the developed model of the Lithosphere-Atmosphere-Ionosphere coupling. The main attention is focused on the processes in the near ground layer of the atmosphere involving the ionization of air by radon, the water molecules' attachment to the formed ions, and the corresponding changes in the latent heat. Model considerations are supported by experimental measurements showing the local diminution of air humidity one week prior to the earthquake, accompanied by the anomalous thermal infrared (TIR signals and surface latent heat flux (SLHF and anomalous variations of the total electron content (TEC registered over the epicenter of the impending earthquake three days prior to the main earthquake event. Statistical processing of the data of the GPS receivers network, together with various other atmospheric parameters demonstrate the possibility of an early warning of an impending strong earthquake.

  11. Dynamic rupture modeling of the M7.2 2010 El Mayor-Cucapah earthquake: Comparison with a geodetic model (United States)

    Kyriakopoulos, Christos; Oglesby, David D.; Funning, Gareth J.; Ryan, Kenneth


    The 2010 Mw 7.2 El Mayor-Cucapah earthquake is the largest event recorded in the broader Southern California-Baja California region in the last 18 years. Here we try to analyze primary features of this type of event by using dynamic rupture simulations based on a multifault interface and later compare our results with space geodetic models. Our results show that starting from homogeneous prestress conditions, slip heterogeneity can be achieved as a result of variable dip angle along strike and the modulation imposed by step over segments. We also considered effects from a topographic free surface and find that although this does not produce significant first-order effects for this earthquake, even a low topographic dome such as the Cucapah range can affect the rupture front pattern and fault slip rate. Finally, we inverted available interferometric synthetic aperture radar data, using the same geometry as the dynamic rupture model, and retrieved the space geodetic slip distribution that serves to constrain the dynamic rupture models. The one to one comparison of the final fault slip pattern generated with dynamic rupture models and the space geodetic inversion show good agreement. Our results lead us to the following conclusion: in a possible multifault rupture scenario, and if we have first-order geometry constraints, dynamic rupture models can be very efficient in predicting large-scale slip heterogeneities that are important for the correct assessment of seismic hazard and the magnitude of future events. Our work contributes to understanding the complex nature of multifault systems.

  12. Analysis of the Source and Ground Motions from the 2017 M8.2 Tehuantepec and M7.1 Puebla Earthquakes (United States)

    Melgar, D.; Sahakian, V. J.; Perez-Campos, X.; Quintanar, L.; Ramirez-Guzman, L.; Spica, Z.; Espindola, V. H.; Ruiz-Angulo, A.; Cabral-Cano, E.; Baltay, A.; Geng, J.


    The September 2017 Tehuantepec and Puebla earthquakes were intra-slab earthquakes that together caused significant damage in broad regions of Mexico, including the states of Oaxaca, Chiapas, Morelos, Puebla, Mexico, and Mexico City. Ground motions in Mexico City have approximately the same angle of incidence from both earthquakes and potentially sample similar paths close to the city. We examine site effects and source terms by analysis of residuals between Ground-Motion Prediction Equations (GMPEs) and observed ground motions for both of these events at stations from the Servicio Sismólogico Nacional, Instituto de Ingeniería, and the Instituto de Geofísica Red del Valle de Mexico networks. GMPEs are a basis for seismic design, but also provide median ground motion values to act as a basis for comparison of individual earthquakes and site responses. First, we invert for finite-fault slip inversions for Tehuantepec with high-rate GPS, static GPS, tide gauge and DART buoy data, and for Puebla with high-rate GPS and strong motion data. Using the distance from the stations with ground motion observations to the derived slip models, we use the GMPEs of Garcia et al. (2005), Zhao et al. (2006), and Abrahamson, Silva and Kamai (2014), to compute predicted values of peak ground acceleration and velocity (PGA and PGV) and response spectral accelerations (SA). Residuals between observed and predicted ground motion parameters are then computed for each recording, and are decomposed into event and site components using a mixed effects regression. We analyze these residuals as an adjustment away from median ground motions in the region to glean information about the earthquake source properties, as well as local site response in and outside of the Mexico City basin. The event and site terms are then compared with available values of stress drop for the two earthquakes, and Vs30 values for the sites, respectively. This analysis is useful in determining which GMPE is most appropriate in the central Mexico region, important for future ground motion studies and rapid response products such as ShakeMap.

  13. Large magnitude (M > 7.5) offshore earthquakes in 2012: few examples of absent or little tsunamigenesis, with implications for tsunami early warning (United States)

    Pagnoni, Gianluca; Armigliato, Alberto; Tinti, Stefano


    We take into account some examples of offshore earthquakes occurred worldwide in year 2012 that were characterised by a "large" magnitude (Mw equal or larger than 7.5) but which produced no or little tsunami effects. Here, "little" is intended as "lower than expected on the basis of the parent earthquake magnitude". The examples we analyse include three earthquakes occurred along the Pacific coasts of Central America (20 March, Mw=7.8, Mexico; 5 September, Mw=7.6, Costa Rica; 7 November, Mw=7.5, Mexico), the Mw=7.6 and Mw=7.7 earthquakes occurred respectively on 31 August and 28 October offshore Philippines and offshore Alaska, and the two Indian Ocean earthquakes registered on a single day (11 April) and characterised by Mw=8.6 and Mw=8.2. For each event, we try to face the problem related to its tsunamigenic potential from two different perspectives. The first can be considered purely scientific and coincides with the question: why was the ensuing tsunami so weak? The answer can be related partly to the particular tectonic setting in the source area, partly to the particular position of the source with respect to the coastline, and finally to the focal mechanism of the earthquake and to the slip distribution on the ruptured fault. The first two pieces of information are available soon after the earthquake occurrence, while the third requires time periods in the order of tens of minutes. The second perspective is more "operational" and coincides with the tsunami early warning perspective, for which the question is: will the earthquake generate a significant tsunami and if so, where will it strike? The Indian Ocean events of 11 April 2012 are perfect examples of the fact that the information on the earthquake magnitude and position alone may not be sufficient to produce reliable tsunami warnings. We emphasise that it is of utmost importance that the focal mechanism determination is obtained in the future much more quickly than it is at present and that this information must be included in the operational procedures of warning systems. On the other hand, we stress the importance of a correct management of false alarms, which are almost impossible to avoid, both in the crisis and in the pot-crisis phases. These are topics whose solution represents one of the major efforts of the EU-FP7 TRIDEC Project, in the frame of which this study is conducted.

  14. Comparison between low-cost and traditional MEMS accelerometers: a case study from the M7.1 Darfield, New Zealand, aftershock deployment

    Directory of Open Access Journals (Sweden)

    Angela Chung


    Full Text Available Recent advances in micro-electro-mechanical systems (MEMS sensing and distributed computing techniques have enabled the development of low-cost, rapidly deployed dense seismic networks. The Quake-Catcher Network (QCN uses triaxial MEMS accelerometers installed in homes and businesses to record moderate to large earthquakes. Real-time accelerations are monitored and information is transferred to a central server using open-source, distributed computing software installed on participating computers. Following the September 3, 2010, Mw 7.1 Darfield, New Zealand, earthquake, 192 QCN stations were installed in a dense array in the city of Christchurch and the surrounding region to record the on-going aftershock sequence. Here, we compare the ground motions recorded by QCN accelerometers with GeoNet strong-motion instruments to verify whether low-cost MEMS accelerometers can provide reliable ground-motion information in network-scale deployments. We find that observed PGA and PGV amplitudes and RMS scatter are comparable between the GeoNet and QCN observations. Closely spaced stations provide similar acceleration, velocity, and displacement time series and computed response spectra are also highly correlated, with correlation coefficients above 0.94.

  15. Evidence for Tether-Cutting Reconnection in a Quadrupole Magnetic Configuration in the April 9, 2001, M7.9 Flare

    Czech Academy of Sciences Publication Activity Database

    Yurchyshyn, V.; Karlický, Marian; Hu, Q.; Wang, H.


    Roč. 235, 1-2 (2006), s. 147-160 ISSN 0038-0938 R&D Projects: GA AV ČR IAA3003202 Institutional research plan: CEZ:AV0Z10030501 Keywords : solar flare * magnetic reconnection Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.887, year: 2006

  16. M7 germplasm release: A tetraploid clone derived from Solanum infundibuliforme for use in expanding the germplasm base for french fry processing (United States)

    A new source of russet germplasm has been identified as a parent for processing and fresh market breeding programs. It was derived via bilateral sexual polyploidization following a cross between a diploid cultivated potato and the diploid wild species Solanum infundibuliforme. This clone, designated...

  17. High-resolution backprojection at regional distance: Application to the Haiti M7.0 earthquake and comparisons with finite source studies (United States)

    Meng, L.; Ampuero, J.-P.; Sladen, A.; Rendon, H.


    A catastrophic Mw7 earthquake ruptured on 12 January 2010 on a complex fault system near Port-au-Prince, Haiti. Offshore rupture is suggested by aftershock locations and marine geophysics studies, but its extent remains difficult to define using geodetic and teleseismic observations. Here we perform the multitaper multiple signal classification (MUSIC) analysis, a high-resolution array technique, at regional distance with recordings from the Venezuela National Seismic Network to resolve high-frequency (about 0.4 Hz) aspects of the earthquake process. Our results indicate westward rupture with two subevents, roughly 35 km apart. In comparison, a lower-frequency finite source inversion with fault geometry based on new geologic and aftershock data shows two slip patches with centroids 21 km apart. Apparent source time functions from USArray further constrain the intersubevent time delay, implying a rupture speed of 3.3 km/s. The tips of the slip zones coincide with subevents imaged by backprojections. The different subevent locations found by backprojection and source inversion suggest spatial complementarity between high- and low-frequency source radiation consistent with high-frequency radiation originating from rupture arrest phases at the edges of main slip areas. The centroid moment tensor (CMT) solution and a geodetic-only inversion have similar moment, indicating most of the moment released is captured by geodetic observations and no additional rupture is required beyond where it is imaged in our preferred model. Our results demonstrate the contribution of backprojections of regional seismic array data for earthquakes down to M ≈ 7, especially when incomplete coverage of seismic and geodetic data implies large uncertainties in source inversions.

  18. Effectiveness of iPad apps on visual-motor skills among children with special needs between 4y0m-7y11m. (United States)

    Coutinho, Franzina; Bosisio, Marie-Elaine; Brown, Emma; Rishikof, Stephanie; Skaf, Elise; Zhang, Xiaoting; Perlman, Cynthia; Kelly, Shannon; Freedin, Erin; Dahan-Oliel, Noemi


    The aim of this randomized controlled trial was to assess the effectiveness of interventions using iPad applications compared to traditional occupational therapy on visual-motor integration (VMI) in school-aged children with poor VMI skills. Twenty children aged 4y0m to 7y11m with poor VMI skills were randomly assigned to the experimental group (interventions using iPad apps targeting VMI skills) or control group (traditional occupational therapy intervention sessions targeting VMI skills). The intervention phase consisted of two 40-min sessions per week, over a period of 10 weeks. Participants were required to attend a minimum of 8 and a maximum of 12 sessions. The subjects were tested using the Beery-VMI and the visual-motor subscale of the M-FUN, at baseline and follow-up. Results from a 2-way mixed design ANOVA yielded significant results for the main effect of time for the M-FUN total raw score, as well as in the subscales Amazing Mazes, Hidden Forks, Go Fishing and VM Behavior. However, gains did not differ between intervention types over time. No significant results were found for the Beery-VMI. This study supports the need for further research into the use of iPads for the development of VMI skills in the pediatric population. Implications for Rehabilitation This is the first study to look at the use of iPads with school-aged children with poor visual-motor skills. There is limited literature related to the use of iPads in pediatric occupational therapy, while they are increasingly being used in practice. When compared to the traditional occupational therapy interventions, participants in the iPad intervention appeared to be more interested, engaged and motivated to participate in the therapy sessions. Using iPad apps as an adjunct to therapy in intervention could be effective in improving VMI skills over time.

  19. Potentiation of cytotoxic action of cis-[PtCl2(NH3)(1M7AI)] by UVA irradiation. Mechanistic insights

    Czech Academy of Sciences Publication Activity Database

    Prachařová, J.; Intini, F. P.; Natile, G.; Kašpárková, Jana; Brabec, Viktor


    Roč. 472, MAR2018 (2018), s. 199-206 ISSN 0020-1693 R&D Projects: GA ČR(CZ) GA17-05302S; GA MŠk(CZ) LO1204 Institutional support: RVO:68081707 Keywords : cisplatin-dna adducts * tumor-cells * cross-links Subject RIV: CE - Biochemistry OBOR OECD: Biochemistry and molecular biology Impact factor: 2.002, year: 2016

  20. Effect of Cr, Ni, and Mo additions on the susceptibility of the 0Kh6n7m7c steel to hot cracking

    International Nuclear Information System (INIS)

    Tolstykh, L.G.; Pryakhin, A.V.; Popov, A.N.; Usynin, V.F.


    The effect of chromium, molybdenum, and nickel on the tendency of surfacing materials to form hot cracks (Vsub(kp) was studied using the mathematical statistics method. The St3 steel and 38KhN3MFA steel were used in the study. A device facilitating the hot cracking tendency test procedure was developed. It was found that, in the concentration range involved, Ni and Mo produce no effect on Vsub(kp), and Cr enhances it. A new powder wire, PP-OKh7N8M6S, capable of increasing surface material resistance by 1.5-2 times, has been developed

  1. Chapter 5: Buildings (EERI Earthquake Reconnaissance Team Report: M7.8 Gorkha, Nepal Earthquake on April 25, 2015 and its Aftershocks) (United States)

    Kaushik, Hemant; Bevington, John; Jaiswal, Kishor; Lizundia, Bret; Shrestha, Surya


    The most common building typologies in Nepal are reinforced concrete (RC) frame buildings with masonry infill walls, unreinforced masonry (URM) bearing wall buildings, and wood frame buildings (Figure 5-1). The RC frames with masonry infills are commonly constructed in urban and semi-urban areas. Most of these buildings are three to five stories high, and most privately owned buildings are non-engineered. High rise buildings (up to 17 stories high) are also found in Kathmandu, but their number is limited. Burnt clay bricks are widely used as masonry infill walls; external walls are generally one full brick thick (~ 230 mm), and internal walls are one half brick thick. URM bearing wall buildings are an obvious choice for the population in rural areas and the outskirts of cities, primarily to limit the material expenses. Such buildings are generally two to four stories high and constructed using burnt clay brick masonry or stone masonry with cement, lime, or mud mortar. In some of the older constructions, a different mortar known as Vajra (a mix of lime and brick dust) is also observed. These buildings have either wooden or reinforced concrete flooring. A hybrid type of construction also prevails in semi-urban and rural areas, where wood frames are used in the ground story front façade, and rest of the house is made of unreinforced masonry bearing walls. Wood frame houses (generally two to three stories high) are also observed in rural areas where the material for such construction is easily available.

  2. Some statistical features of the aftershock temporal behavior after the M7.4 Izmit earthquake of august 17, 1999 in Turkey (United States)

    Gospodinov, D.; Fajtin, H.; Rangelov, B.; Marekova, E.


    An earthquake of magnitude Mw=7.4 struck 8 km. southeast of Izmit, Turkey at 3:02 AM local time on August 17, 1999. The earthquake occurred on one of the world's longest and best studied strike-slip (horizontal motion) faults - the east-west trending North Anatolian fault. Seismologists are not able to predict the timing and sizes of individual aftershocks but stochastic modeling allows determinationof probabilities for aftershocks and larger mainshocks duringintervals following the mainshock. The most widely applied stochastic model to depict aftershocks temporal distribution is the non- homogenous Poisson process with a decaying intensity, which follows the Modified Omori Formula (MOF) (Utsu, 1961). A more complex model, considering the triggering potential of each aftershock was developed by Ogata (1988) and it was named Epidemic Type Aftershock Sequence (ETAS) model. Gospodinov and Rotondi (2006) elaborated a Restricted Epidemic Type Aftershock Sequence (RETAS) model. The latter follows the general idea that only aftershocks stronger than some cut-off magnitude possess the capability to induce secondary aftershock activity. In this work we shall consider the Restricted Epidemic Type Aftershock Sequence (RETAS) model, for which the conditional intensity function turns out to be ‘ K0eα(Mi-M0)- λ (t|Ht) = + (t- ti + c)p ti model versions between the MOF and the ETAS model on the basis of the Akaike Information Criterion AIC (Akaike, 1974) AIC = - 2max log L+ 2k (2) where k is the number of parameters used in the model and logL is the logarithm of the likelihood function. Then for the model providing the best fit, we choose the one with the smallest AIC value. The purpose of this paper is to verify versions of the RETAS model (including the MOF and the ETAS model) for the analysis of the aftershock sequence after the Mw=7.4 Izmit earthquake. The obtained results revealed that the best fit model is ETAS, for which the triggering magnitude coincides with the lower cut-off. In this case each event in the sequence can generate its own secondary events. The analysis points out that about 12 days before the Duzce earthquake a relative quiescence begins which then turns to a relative activization about 5 days before the strong shock. This can be explained by a possible realization of several stronger aftershocks before the Duzce event, which are considered as its foreshocks. Another result which can be outlined is that the MOF model is not good for a sequence in which we have secondary activity (strong aftershock or several main events). For a complex aftershock sequence as is the case for the Izmit-Duzce zone, it is adequate to apply the RETAS model which gives more possibilities to model the aftershock activity in time. This allows to perform a better geotectonic interpretation later. The analysis of the aftershock activity after the strong Izmit earthquake, executed through the RETAS model makes it possible to draw some conclusions when interpreting the results: - The RETAS model supplies a methodology to identify the best fit model of the relaxation temporal development and in our case this is the ETAS model (each aftershock is capable to trigger secondary activity). - The recognized best fit model for the sequence provides an opportunity to identify separate periods of relative quiescence and activization. A quiescence period of several days was identified before the strongest aftershock - the Duzce earthquake. - For standard aftershock sequences the different versions of the RETAS model (ETAS, MOF and the intermediate ones) are closer to each other. For a more complex sequence with strong aftershock activity the RETAS model provides better possibilities to model the temporal aspect of the relaxation process and to perform the most adequate geotectonic interpretation. References Akaike, H., 1974, A new look at the statistical model identification. IEEE Trans. Automat. Contr. AC-19, 716-723. Gospodinov, D., R. Rotondi, 2006, Statistical Analysis of Triggered Seismicity in the Kresna Region of SW Bulgaria (1904) and the Umbria-Marche Region of Central Italy (1997). Pure Appl. Geophys. 163, 1597-1615. Ogata, Y., 1988, Statistical models for earthquake occurrences and residual analysis for point processes. J. Am. Stat. Assoc. 83, 9-27. Utsu, T., 1961, A statistical study on the occurrence of aftershocks, Geophys. Mag., 30, 521-605

  3. Testing earthquake links in Mexico from 1978 up to the 2017 M=8.1 Chiapas and M=7.1 Puebla shocks (United States)

    Segou, Margarita; Parsons, Thomas E.


    The M = 8.1 Chiapas and the M = 7.1 Puebla earthquakes occurred in the bending part of the subducting Cocos plate 11 days and ~600 km apart, a range that puts them well outside the typical aftershock zone. We find this to be a relatively common occurrence in Mexico, with 14% of M > 7.0 earthquakes since 1900 striking more than 300 km apart and within a 2 week interval, not different from a randomized catalog. We calculate the triggering potential caused by crustal stress redistribution from large subduction earthquakes over the last 40 years. There is no evidence that static stress transfer or dynamic triggering from the 8 September Chiapas earthquake promoted the 19 September earthquake. Both recent earthquakes were promoted by past thrust events instead, including delayed afterslip from the 2012 M = 7.5 Oaxaca earthquake. A repeated pattern of shallow thrust events promoting deep intraslab earthquakes is observed over the past 40 years.

  4. Comparison of Structurally Controlled Landslide Hazard Simulation to the Co-seismic Landslides Caused by the M 7.2 2013 Bohol Earthquake. (United States)

    Galang, J. A. M. B.; Eco, R. C.; Lagmay, A. M. A.


    The M_w 7.2 October 15, 2013 Bohol earthquake is one of the more destructive earthquake to hit the Philippines in the 21st century. The epicenter was located in Sagbayan municipality, central Bohol and was generated by a previously unmapped reverse fault called the "Inabanga Fault". The earthquake resulted in 209 fatalities and over 57 million USD worth of damages. The earthquake generated co-seismic landslides most of which were related to fault structures. Unlike rainfall induced landslides, the trigger for co-seismic landslides happen without warning. Preparations for this type of landslides rely heavily on the identification of fracture-related slope instability. To mitigate the impacts of co-seismic landslide hazards, morpho-structural orientations of discontinuity sets were mapped using remote sensing techniques with the aid of a Digital Terrain Model (DTM) obtained in 2012. The DTM used is an IFSAR derived image with a 5-meter pixel resolution and approximately 0.5 meter vertical accuracy. Coltop 3D software was then used to identify similar structures including measurement of their dip and dip directions. The chosen discontinuity sets were then keyed into Matterocking software to identify potential rock slide zones due to planar or wedged discontinuities. After identifying the structurally-controlled unstable slopes, the rock mass propagation extent of the possible rock slides was simulated using Conefall. Separately, a manually derived landslide inventory has been performed using post-earthquake satellite images and LIDAR. The results were compared to the landslide inventory which identified at least 873 landslides. Out of the 873 landslides identified through the inventory, 786 or 90% intersect the simulated structural-controlled landslide hazard areas of Bohol. The results show the potential of this method to identify co-seismic landslide hazard areas for disaster mitigation. Along with computer methods to simulate shallow landslides, and debris flow paths, located structurally-controlled unstable zones can be used to mark unsafe areas for settlement. The method can be further improved with the use of Lidar DTMs, which has better spatial resolution than the IFSAR DTM. A nationwide effort under DOST-Project NOAH (DREAM-LIDAR) is underway, to map the Philippine archipelago using Lidar.

  5. The Impacts of Type 1 Diabetes on the K-12 Educational Experience (United States)

    McKerns-O'Donnell, Monica A.


    The purpose of this qualitative research study was to uncover the impacts that type 1 diabetes have on a child's or adolescent's school educational experience. The study used a phenomenological approach based upon the work of Moustakas (1994). Purposeful sampling was used to identify participants. The participant group was comprised of 10…

  6. The Lived Experience of Teachers and Administrators in Persistently Low Achieving Schools (United States)

    Bickenheuser, Charles William


    In 2010 Washington State's persistently lowest performing public schools were identified and published by the superintendent of public instruction. However, no research has described the lived experiences of teachers and administrators who work in those schools. Guided by the combined frameworks of Van Manen and Moustakas, this qualitative study…

  7. A Phenomenological Study of Falling out of Romantic Love (United States)

    Sailor, Joanni L.


    Romantic love is considered a necessary ingredient in marriage. In this study, the experience of falling out of romantic love with one's spouse was examined. Eight individuals who had fallen out of romantic love with their spouse were interviewed. By using Moustakas' Transcendental Phenomenological method, several themes emerged which provided a…

  8. At the Crossroads: Portrait of an Undergraduate Composition Teacher Whose Heuristics Were Transformed by Computer-Technology (United States)

    Grover, Susan Hendricks


    Heuristics are deeply-held, tacit knowledge structures connected to our feelings. A heuristic study explores a phenomenon crucial to the researcher's self-discovery (Moustakas, 1990). Like me, many undergraduate composition instructors feel both fear and hope at the crossroads of composition and technology. Technology and composition shape one…

  9. Twilight of the Slogans: A Heuristic Investigation of Linguistic Memes Using Mixed Methods (United States)

    Duffy, Curt Paul


    Slogans, or linguistic memes, are short, memorable phrases that are present in commercial, political, and everyday discourse. Slogans propagate similarly to other memes, or cultural units, through an evolutionary mechanism first proposed by Dawkins (1976). Heuristic inquiry, as presented by Moustakas (1990), provided a template from which to…

  10. Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA

    DEFF Research Database (Denmark)

    Wang, Kai-Tuo; Desmolaize, Benoit; Nan, Jie


    to be fusions from two separate proteins found in Gram-positives. The crystal structures described here show that both the N- and C-terminal halves of E. coli YcbY have a methyltransferase active site and their folding patterns respectively resemble the Streptococcus mutans proteins Smu472 and Smu776. Mass...

  11. Long Range Effect of The M7.8 April 2015 Nepal Earth Quake on the Deep Groudwater Outflow in a Thousand-Mile-Away Geothermal Field in Southern China's Guangdong (United States)

    Lu, G.; Yu, S.; Xu, F.; Wang, X.; Yan, K.; Yuen, D. A.


    Deep ground waters sustain high temperature and pressure and are susceptible to impact from an earthquake. How an earthquake would have been associated with long-range effect on geological environment of deep groundwater is a question of interest to the scientific community and general public. The massive Richter 8.1 Nepal Earthquake (on April 25, 2015) provided a rare opportunity to test the response of deep groundwater systems. Deep ground waters at elevated temperature would naturally flow to ground surface along preferential flow path such as a deep fault, forming geothermal water flows. Geothermal water flows are susceptible to stress variation and can reflect the physical conditions of supercritical hot water kilometers deep down inside the crust. This paper introduces the monitoring work on the outflow in Xijiang Geothermal Field of Xinyi City, Guangdong Province in southern China. The geothermal field is one of typical geothermal fields with deep faults in Guangdong. The geothermal spring has characteristic daily variation of up to 72% in flow rate, which results from being associated with a north-south run deep fault susceptible to earthquake event. We use year-long monitoring data to illustrate how the Nepal earthquake would have affected the flows at the field site over 2.5 thousand kilometers away. The irregularity of flow is judged by deviation from otherwise good correlation of geothermal spring flow with solid earth tidal waves. This work could potentially provide the basis for further study of deep groundwater systems and insight to earthquake prediction.

  12. Pressure distribution data from tests of 2.29 M (7.5 feet) span EET high-lift transport aircraft model in the Ames 12-foot pressure tunnel (United States)

    Kjelgaard, S. O.; Morgan, H. L., Jr.


    A high-lift transport aircraft model equipped with full-span leading-edge slat and part-span double-slotted trailing-edge flap was tested in the Ames 12-ft pressure tunnel to determine the low-speed performance characteristics of a representative high-aspect-ratio supercritical wing. These tests were performed in support of the Energy Efficient Transport (EET) program which is one element of the Aircraft Energy Efficiency (ACEE) project. Static longitudinal forces and moments and chordwise pressure distributions at three spanwise stations were measured for cruise, climb, two take-off flap, and two landing flap wing configurations. The tabulated and plotted pressure distribution data is presented without analysis or discussion.

  13. La amenaza sísmica de la Sabana de Bogotá frente a un sismo de magnitud M > 7.0, cuyo origen esté en el Piedemonte Llanero

    Directory of Open Access Journals (Sweden)

    German Chicangana


    Full Text Available En este trabajo se pasa a mostrar como un gran sismo originado en el Sistema de Fallas de la Falla Frontal de la Cordillera Oriental (SFFFCO puede producir grandes daños y pérdidas de vida tanto en el área metropolitana de Bogotá, como en el resto de la Sabana de Bogotá. El grado de la vulnerabilidad de Bogotá D.C. frente a un sismo cercano originado en el Piedemonte Llanero con una distancia inferior a 250 Km con una magnitud > 7.0, es muy alto teniendo presente que sus suelos de origen lagunar se ubican hacía el occidente y noroccidente, zonas que durante las dos últimas décadas se ha ido expansionado el área metropolitana.

  14. Using Transcendental Phenomenology to Explore the “Ripple Effect” in a Leadership Mentoring Program

    Directory of Open Access Journals (Sweden)

    Tammy Moerer-Urdahl


    Full Text Available Several approaches exist for organizing and analyzing data in a phenomenological qualitative study. Transcendental phenomenology, based on principles identified by Husserl (1931 and translated into a qualitative method by Moustakas (1994, holds promise as a viable procedure for phenomenological research. However, to best understand the approach to transcendental phenomenology, the procedures need to be illustrated by a qualitative study that employs this approach. This article first discusses the procedures for organizing and analyzing data according to Moustakas (1994. Then it illustrates each step in the data analysis procedure of transcendental phenomenology using a study of reinvestment or the “ripple effect” for nine individuals who have participated in a youth leadership mentoring program from the 1970s to the present. Transcendental phenomenology works well for this study as this methodology provides logical, systematic, and coherent design elements that lead to an essential description of the experience.

  15. Photonics Research and Technology Insertion (United States)


    state devices are intended to replace the present low-pressure mercury lamp emitting at 254nm. Approach: The BU team is a leader in UV LED ...7 Development of UV LEDs Emitting at 250-260 nm for Water-Air Purification and Surface Sterilization Task Manager: Professors Enrico Bellotti...Theodore Moustakas and Roberto Paiella/Leah Ziph-Schatzberg Objective: The team set out to develop electrically pumped UV LEDs emitting at 250

  16. Using Transcendental Phenomenology to Explore the “Ripple Effect” in a Leadership Mentoring Program


    Tammy Moerer-Urdahl; John W. Creswell


    Several approaches exist for organizing and analyzing data in a phenomenological qualitative study. Transcendental phenomenology, based on principles identified by Husserl (1931) and translated into a qualitative method by Moustakas (1994), holds promise as a viable procedure for phenomenological research. However, to best understand the approach to transcendental phenomenology, the procedures need to be illustrated by a qualitative study that employs this approach. This article first discuss...

  17. Imaging inhomogeneous seismic velocity structure in and around the fault plane of the 2008 Iwate-Miyagi, Japan, Nairiku Earthquake (M7.2) - spatial variation in depth of seismic-aseismic transition and possible high-T/overpressurized fluid distribution (United States)

    Okada, T.; Umino, N.; Hasegawa, A.; 2008 Iwate-Miyagi Nairiku Earthquake, G. O.


    A large shallow earthquake (named the 2008 Iwate-Miyagi Nairiku Earthquake) with a JMA magnitude of 7.2 occurred in the central part of NE Japan on June 14, 2008. Focal area of the present earthquake is located in the Tohoku backbone range strain concentration zone (Miura et al., 2004) along the volcanic front. Just after the occurrence of this earthquake, Japanese universities (Hokkaido, Hirosaki, Tohoku, Tokyo, Nagoya, Kyoto, Kochi, Kyusyu, Kagoshima) and NIED deployed a dense aftershock observation network in and around the focal area. Total number of temporal stations is 128. Using data from this dense aftershock observation and other temporary and routinely operated stations, we estimate hypocenter distribution and seismic velocity structure of the crust in and around the focal area of the present earthquake. We determined three-dimensional seismic velocity structure and relocated hypocenters simultaneously using the double- difference tomography method (Zhang and Thurber, 2003). Spatial extent of the aftershock area is about 45 km (NNE-SSW) by 15 km (WNW-ESE). Most of aftershocks are aligned in westward dipping. Shallower extensions of aftershock alignments seem to be located nearly at the coseismic surface deformations, which are along a geological fault, and the surface trace of the active fault (Detana fault). Note that some aftershocks seem to occur off the fault plane of the mainshock. The focal area of the present earthquake is located at a high Vs area. In the lower crust, we found some distinct low-Vs areas. These low velocity zones are located just beneath the strain concentration zones / seismic belts along the backbone range and in the northern Miyagi region. Focal area of the present earthquake is also located just above the low velocity zone in the lower crust. Beneath active volcanoes, these low velocity zones become more distinct and shallower, and aftershocks tend to occur shallower and not occur within such low-velocity zones. These low-velocity zones in the lower crust might be caused by high temperature upwelling flow of fluid originating from the mantle wedge. The present observation supports the hypothesis by Hasegawa et al. (2005) that anelastic deformation of the crust weakened by fluid forms the strain concentration zone and promotes the occurrence of large shallow inland earthquakes. We used data from JMA, Hi-net/NIED, NAO-Mizusawa and TITECH. We also used data from JNES. This work was conducted under the support of Grant-in-Aid for Special Purposes, MEXT, Japan. We thank Prof. Cliff Thurber and Dr. Haijiang Zhang for providing their programs and valuable discussions.

  18. Tensions and dilemmas in body-pedagogy in kindergarten

    DEFF Research Database (Denmark)

    Herskind, Mia


      This paper concerns a research-based evaluation of Danish kindergarten employees and their experiences of an educational project ‘Moving Children' and the learning processes that followed in kindergarten in which they aimed to develop a body-pedagogy in order to increase the physical activity i...... on a phenomenological frame of reference (Merleau-Ponty 1964; Zahavi, 2003; van Manen, 1998; Moustakas, 1994; Spinelli, 2005) the study underlines the significance of bringing in the bodily narratives in investigations of body-pedagogy....


    Directory of Open Access Journals (Sweden)

    Oğuzhan YILMAZ


    Full Text Available This study was done to determine 7th grade primary school students' grammar skills in terms of socio-cultural variables. The sample of this study ,which was done via screening model, was selected with"cluster sampling" techniques. An achievment test was developed by taking the experts' view into consideration and this achievement test was given to students via an information form that can meaure socio-cultural behaviour. The obtained data were analyzed with SPSS 16. In order to test the two variables that can make difference on language skills "Independent Samples T-Test" and for more than two variables One Way ANOVA was used. When ANOVA could not meet normality hypothesis Kruskal Wallis H-Test was applied. As a result of our study it was found that the students who have their own library have better language skills and the variables such as gender, monthly income, father's/mother's job, father's/mother's level of education, ownership status of the house, having a private room, the habit of buying newspaper, studying lesson, and free time activities have not effect on students' language skills. Bu çalışma, ilköğretim 7. sınıf öğrencilerinin dil bilgisi becerilerini sosyokültürel değişkenler açısından incelemek amacıyla yapılmıştır. Tarama modeliyle yapılan bu çalışmanın örneklemi “kümelere göre örnekleme” tekniğiyle seçilmiştir. Verilerin toplanması için uzman görüşleri alınarak bir başarı testi geliştirilmiş ve bu başarı testi, sosyokültürel davranışlarını ölçecek nitelikte bir bilgi formu ile öğrencilere sunulmuştur. Toplanan veriler SPSS 16 programı vasıtasıyla analiz edilmiştir. Dil bilgisi becerileri üzerinde farklılık oluşturabilecek iki değişkenin test edilmesinde “Bağımsız Gruplar Arası T-Testi (Independent Samples T-Test”, ikiden fazla değişkenin test edilmesindeyse “Tek Yönlü Varyans Analizi (One Way ANOVA” kullanılmıştır. ANOVA testinin normallik varsayımını karşılamadığı durumlarda Kruskal Wallis HTestine müracaat edilmiştir. Çalışmanın sonucunda kendine ait bir kütüphanesi olan öğrencilerin dil bilgisi becerileri bakımından üst düzeyde olduğu tespit edilirken, cinsiyet, aylık gelir, anne-baba mesleği, anne-baba eğitim düzeyi, oturulan evin mülkiyet durumu, kendine ait oda durumu, eve gazete alma alışkanlığı, ders çalışma ve boş zamanları değerlendirme faaliyetleri gibi değişkenlerin öğrencilerin dil bilgisi becerileri üzerinde etkili olmadığı tespit edilmiştir.

  20. An Exploration of Leadership in Virtual Communities of Practice

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    John T. Chrisentary


    Full Text Available This qualitative phenomenological research study represents the personal and professional lived experiences of midlevel leaders’ effective management of virtual committees of practice (VCoP in medical device companies in the Atlanta metro area. In-depth interviews were conducted with 15 leaders of VCoP from different medical device functional specialties. The study used a combination of the modified van Manen (1990 and van Kaam methods (Moustakas, 1994 to facilitate the analysis of the data gathered through in-depth interviews. This method served as the template for data collection and analysis. The research study revealed common themes after an analysis of data. Six emergent themes were identified: (a empowerment, (b communication, (c trust, (d encouragement/inspiration, (e integrity, and (f connecting with individuals. The research findings revealed a leadership model that relies on the development of genuine leaders/follower relationships to lead a VCoP effectively.

  1. Outsourcing within aerospace manufacturing enterprises: A phenomenological study and outsourcing leadership model (United States)

    Sampson, Enrique, Jr.

    Many aerospace workers believe transferring work projects abroad has an erosive effect on the U.S. aerospace industry (Pritchard, 2002). This qualitative phenomenological study examines factors for outsourcing decisions and the perceived effects of outsourcing on U.S. aerospace workers. The research sample consists of aerospace industry leaders and nonleaders from the East Coast, Midwest, and West Coast of the United States. Moustakas' modified van Kaam methods of analysis (1994) and Decision Explorer analysis software were applied to the interview transcripts. Resultant data identified five core themes: communication, best value, opportunities, cost, and offset consideration. The themes provided the framework for a model designed to assist leaders in making effective decisions and communicating the benefits of those decisions when considering outsourcing of work projects.

  2. Collaboration between science teacher educators and science faculty from arts and sciences for the purpose of developing a middle childhood science teacher education program: A case study (United States)

    Buck, Gayle A.


    The science teacher educators at a midwestern university set a goal to establish a collaborative relationship between themselves and representatives from the College of Arts & Sciences for the purpose of developing a middle childhood science education program. The coming together of these two faculties provided a unique opportunity to explore the issues and experiences that emerge as such a collaborative relationship is formed. In order to gain a holistic perspective of the collaboration, a phenomenological case study design and methods were utilized. The study took a qualitative approach to allow the experiences and issues to emerge in a naturalistic manner. The question, 'What are the issues and experiences that emerge as science teacher educators and science faculty attempt to form a collaborative relationship for the purpose of developing a middle childhood science teacher program?' was answered by gathering a wealth of data. These data were collected by means of semi-structured interviews, observations and written document reviews. An overall picture was painted of the case by means of heuristic, phenomenological, and issues analyses. The researcher followed Moustakas' Phases of Heuristic Research to answer the questions 'What does science mean to me?' and 'What are my beliefs about the issues guiding this case?' prior to completing the phenomenological analysis. The phenomenological analysis followed Moustakas' 'Modification of the Van Kaam Methods of Analysis of Phenomenological Data'. This inquiry showed that the participants in this study came to the collaboration for many different reasons and ideas about the purpose for such a relationship. The participants also had very different ideas about how such a relationship should be conducted. These differences combined to create some issues that affected the development of curriculum and instruction. The issues involved the lack of (a) mutual respect for the work of the partners, (b) understanding about the

  3. A phenomenological study on the impacts of embedding disciplinary literacy during science instruction on elementary teachers' metacognition of instructional techniques (United States)

    Weiss, Kelley

    The educational community has been increasing its focus on literacy for several years. The modern definition of literacy requires students to be an informed and integrated thinker, synthesizing new information beyond the mere ability to read and write (Guzzetti & Bang, 2011). This qualitative phenomenological study focused on how teachers of science view literacy and how that view changes when they implement the concept of disciplinary literacy into science instruction. This phenomenological study examined how teachers became more metacognitive of their instructional methods after implementation of the Question-Answer Relationship strategy (QAR) and direct vocabulary instruction into their science instruction. Teachers utilized schema theory and social cognitive theory to integrate the two strategies into their science lessons throughout the study. This phenomenological study collected data during a six-week implementation period through interviews, observations, teacher journals and collection of artifacts from 12 teachers who taught students in grades one through five and three literacy specialists in a rural central Maine school. These data sources were analyzed using Moustakas' (1994) seven steps to discover themes that were identified from the data. Findings from this study, as viewed through the pragmatic lens, suggested that teachers benefit from systematic reflection of their teaching to develop literacy rich content area lessons that address all of the students' learning needs.

  4. Pathways of Reflection: Creating Voice Through Life Story and Dialogical Poetry

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    Lynn Margaret Norton


    Full Text Available In this article, I explore pathways towards critical reflexivity as a way of understanding the interaction between personal and professional development. How much do we, and can we, put our personal lives into our work? Reflexivity can be developed through various methods but is explored herein through life stories and dialogical poetry as ways of deepening the connection between personal discourses and professional lives. A heuristic inquiry framework developed by Clark MOUSTAKAS is used together with poetry and dialogue to map a personal exploration of reflexivity through life story work. The journey follows six phases: initial engagement, immersion, incubation, illumination, explication, and culmination in a creative synthesis. Acknowledging that reflexivity is viewed as occurring in context, a narrative lens is used to integrate the importance of working with lived experience while recognizing how we are influenced by our past and present social interaction with others. In this way, as researchers and professionals, we are better able to position ourselves, to better understand the context in which we work, and to develop a more ethical lens through which we view our reality. The scope for personal agency and the creation of voice is explored through these interactions. URN:

  5. NGC 1266 As a local candidate for rapid cessation of star formation

    Energy Technology Data Exchange (ETDEWEB)

    Alatalo, Katherine; Graves, Genevieve; Blitz, Leo [Department of Astronomy, Hearst Field Annex, University of California, Berkeley, CA 94720 (United States); Nyland, Kristina; Young, Lisa M. [Physics Department, New Mexico Technology, Socorro, NM 87801 (United States); Deustua, Susana [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Griffin, Kristen Shapiro [Space Sciences Research Group, Northrop Grumman Aerospace Systems, Redondo Beach, CA 90278 (United States); Duc, Pierre-Alain; Bournaud, Frédéric [Laboratoire AIM Paris-Saclay, CEA/IRFU/SAp—CNRS—Université Paris Diderot, F-91191 Gif-sur-Yvette, Cedex (France); Cappellari, Michele; Bayet, Estelle; Bureau, Martin; Davies, Roger L. [Sub-Department of Astrophysics, Department of Physics, University of Oxford, Denys Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom); McDermid, Richard M. [Australian Astronomical Observatory, P.O. Box 296, Epping, NSW 1710 (Australia); Davis, Timothy A. [European Southern Observatory, Karl-Schwarzschild-Street 2, D-85748 Garching (Germany); Crocker, Alison F. [Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606 (United States); Chang, Philip [Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, WI 53201 (United States); Scott, Nicholas [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, P.O. Box 218, Hawthorn VIC 3122 (Australia); Cales, Sabrina L. [Department of Astronomy, Faculty of Physical and Mathematical Sciences, Universidad de Concepción, Casilla 160-C, Concepción (Chile); Bois, Maxime [Observatoire de Paris, LERMA and CNRS, 61 Avenue de l' Observatoire, F-75014 Paris (France); and others


    We present new Spectrographic Areal Unit for Research on Optical Nebulae (SAURON) integral-field spectroscopy and Swift Ultraviolet Optical Telescope (UVOT) observations of molecular outflow host galaxy NGC 1266 that indicate NGC 1266 has experienced a rapid cessation of star formation. Both the SAURON maps of stellar population age and the Swift UVOT observations demonstrate the presence of young (<1 Gyr) stellar populations within the central 1 kpc, while existing Combined Array for Research in Millimeter-Wave Astronomy CO(1-0) maps indicate that the sites of current star formation are constrained to only the inner few hundred parsecs of the galaxy. The optical spectrum of NGC 1266 from Moustakas and Kennicutt reveal a characteristic poststarburst (K+A) stellar population, and Davis et al. confirm that ionized gas emission in the system originate from a shock. Galaxies with K+A spectra and shock-like ionized gas line ratios may comprise an important, overlooked segment of the poststarburst population, containing exactly those objects in which the active galactic nucleus (AGN) is actively expelling the star-forming material. While AGN activity is not the likely driver of the poststarburst event that occurred 500 Myr ago, the faint spiral structure seen in the Hubble Space Telescope Wide-field Camera 3 Y-, J- and H-band imaging seems to point to the possibility of gravitational torques being the culprit. If the molecular gas were driven into the center at the same time as the larger scale galaxy disk underwent quenching, the AGN might be able to sustain the presence of molecular gas for ≳ 1 Gyr by cyclically injecting turbulent energy into the dense molecular gas via a radio jet, inhibiting star formation.

  6. Developing practical knowledge content of emergency nursing professionals. (United States)

    Chu, Wen; Hsu, Li-Ling


    There is a paucity of published research on clinical or practical nursing knowledge. The ways that nurses acquire, develop, and maintain emergency room (ER) nursing care skills is a research area, in particular, that deserves further investigation. This study examined clinical setting learning processes to better understand the practical knowledge content of ER nurses. This study used a phenomenological approach and in-depth interviews of 10 nurses. Each participant had at least 3 years of ER experience. Researchers used Moustakas' method to analyze interview data. Findings were checked for credibility, transferability, dependability, and confirmability. The authors identified four major practical knowledge themes for ER professionals. These were (a) basic emergency treatment procedure routines and symptom management; (b) disease mechanisms, pharmacodynamics, and treatment responses; (c) newly identified diseases, updated emergency treatments and techniques, and medical treatment discussions; and (d) identifying nursing values including nursing attitudes and continuing patient care. Participants in this study had experience with the first three themes and successfully combined various types of nursing knowledge in their nursing care duties. Only few participants indicated experience with the fourth theme. Findings clarify that clinical or practical knowledge in ER nurses evolves first from declarative knowledge (e.g., basic emergency treatment routines and operating procedures) to procedural knowledge (e.g., instructions from supervisors, actual practice, and drills) to conditional knowledge (e.g., observation and treatment involving direct interactions with patients). Nurses should combine and apply the various knowledge types in their nursing practice to assess comprehensively each patient's condition and administer effective treatment and service.

  7. May I see your ID, please? An explorative study of the professional identity of undergraduate medical education leaders. (United States)

    Sundberg, Kristina; Josephson, Anna; Reeves, Scott; Nordquist, Jonas


    The mission of undergraduate medical education leaders is to strive towards the enhancement of quality of medical education and health care. The aim of this qualitative study is, with the help of critical perspectives, to contribute to the research area of undergraduate medical education leaders and their identity formation; how can the identity of undergraduate medical education leaders be defined and further explored from a power perspective? In this explorative study, 14 educational leaders at a medical programme in Scandinavia were interviewed through semi-structured interviews. The data was analysed through Moustakas' structured, phenomenological analysis approach and then pattern matched with Gee's power-based identity model. Educational leaders identify themselves more as mediators than leaders and do not feel to any larger extent that their professional identity is authorised by the university. These factors potentially create difficulties when trying to communicate with medical teachers, often also with a weaker sense of professional identity, about medical education. The perceptions of the professional identity of undergraduate medical education leaders provide us with important notions on the complexities on executing their important mission to develop medical education: their perceptions of ambiguity towards the process of trying to lead teachers toward educational development and a perceived lack of authorisation of their work from the university level. These are important flaws to observe and correct when improving the context in which undergraduate medical education leaders are trying to develop and improve undergraduate medical programmes. A practical outcome of the results of this study is the facilitation of design of faculty development programmes for educational leaders in undergraduate medial education.

  8. Molecular cytogenetics for acute megakaryocytic leukemia diagnosis

    Directory of Open Access Journals (Sweden)

    E. A. Matveeva


    Full Text Available Acute megakaryocytic leukemia (AML M7 – a rare disease characterized by poor treatment response, except for t(1;22 variant in infants. Cytogenetic abnormalities in AML M7 are highly heterogeneous. We collected samples from children with AML M7 to analyze the disease cytogenetic profile. During September 2009 to March 2012 20 AML M7 patients was studied using fluorescence in situ hybridization. Complex and heterogeneous chromosomal abnormalities were revealed. It was found that no recurring abnormalities and cytogenetic markers unique to each patients. Also, the 19p13 amplification described previously only in myeloid cell lines was detected.

  9. Molecular cytogenetics for acute megakaryocytic leukemia diagnosis

    Directory of Open Access Journals (Sweden)

    E. A. Matveeva


    Full Text Available Acute megakaryocytic leukemia (AML M7 – a rare disease characterized by poor treatment response, except for t(1;22 variant in infants. Cytogenetic abnormalities in AML M7 are highly heterogeneous. We collected samples from children with AML M7 to analyze the disease cytogenetic profile. During September 2009 to March 2012 20 AML M7 patients was studied using fluorescence in situ hybridization. Complex and heterogeneous chromosomal abnormalities were revealed. It was found that no recurring abnormalities and cytogenetic markers unique to each patients. Also, the 19p13 amplification described previously only in myeloid cell lines was detected.

  10. The impact of an outdoor wilderness program on the participants' sense of connectedness to the natural world (United States)

    Nodurft, Susan Jennings Johnson

    The main objective of this study was to determine the impact of an innovative, outdoor wilderness program on the participants' sense of connectedness with the natural world. Ancillary objectives looked at the impact of epistemological and pedagogical program elements, participants' people and place background experiences, and worldviews on this connectedness sense. The weekend program, based upon a philosophy of deep ecology, draws upon the Native American wisdom tradition and employs a pedagogy of myth, modeling and experiential learning. The researcher and fourteen volunteers primarily drawn from biology classes at a community college participated in the study. Snyder's (1988) four themes of connectedness and a heuristic qualitative design described by Moustakas (1990) were employed in determining the essence of impact. Data collection methods included pre- and post-questionnaires, audio and video tapes of the weekend, field notes, journals, and follow-up interviews. Upon completion of data gathering, three co-researchers were selected for focus study. Results of analysis are described in the form of in-depth profiles of the three co-researchers' experiences containing verbatim narration and common themes explicated from those profiles. Findings revealed that (1) the co-researchers experienced a deep and transforming sense of connectedness with the natural world, (2) a number of key program elements could be identified that facilitated connectedness, (3) childhood experiences played a significant role, and (4) pre-existing biocentric worldviews deepened as a result of the wilderness experience. Several important implications resulted from this study: (1) Transformative programs such as the outdoor program in this study, virtually nonexistent in mainstream environmental education, need to be taken seriously and efforts made to incorporate these types of programs in our public schools, (2) science educators need to examine and amend a belief structure which, in

  11. Solution of the effective Hamiltonian of impurity hopping between two sites in a metal (United States)

    Ye, Jinwu


    We analyze in detail all the possible fixed points of the effective Hamiltonian of a nonmagnetic impurity hopping between two sites in a metal obtained by Moustakas and Fisher (MF). We find a line of non-Fermi liquid fixed points which continuously interpolates between the two-channel Kondo fixed point (2CK) and the one-channel, two-impurity Kondo (2IK) fixed point. There is one relevant direction with scaling dimension 12 and one leading irrelevant operator with dimension 32. There is also one marginal operator in the spin sector moving along this line. The marginal operator, combined with the leading irrelevant operator, will generate the relevant operator. For the general position on this line, the leading low-temperature exponents of the specific heat, the hopping susceptibility and the electron conductivity Cimp,χhimp,σ(T) are the same as those of the 2CK, but the finite-size spectrum depends on the position on the line. No universal ratios can be formed from the amplitudes of the three quantities except at the 2CK point on this line where the universal ratios can be formed. At the 2IK point on this line, σ(T)~2σu(1+aT3/2), no universal ratio can be formed either. The additional non-Fermi-liquid fixed point found by MF has the same symmetry as the 2IK, it has two relevant directions with scaling dimension 12, and is therefore also unstable. The leading low-temperature behaviors are Cimp~T,χhimp~lnT,σ(T)~2σu(1+aT3/2) no universal ratios can be formed. The system is shown to flow to a line of Fermi-liquid fixed points which continuously interpolates between the noninteracting fixed point and the two-channel spin-flavor Kondo fixed point discussed by the author previously. The effect of particle-hole symmetry breaking is discussed. The effective Hamiltonian in the external magnetic field is analyzed. The scaling functions for the physical measurable quantities are derived in the different regimes; their predictions for the experiments are given. Finally

  12. 76 FR 17471 - Air Tour Management Plan for Haleakala National Park, Maui, HI; Public Meeting/Notice of... (United States)


    ... Haleakala National Park, Maui, HI; Public Meeting/Notice of Availability, Review, and Comment on...), Alexa Higashi Meeting Room, One Cameron Way, Kahului, HI 96732. Wednesday, April 13, 2011, 5 p.m.-7 p.m. Kula Community Center, 3690 Lower Kula Road, Kula, HI 96790. Thursday, April 14, 2011, 5 p.m.-7 p.m...

  13. Massive periosteal reaction a presenting feature of acute megakaryocytic leukemia. (United States)

    Ueda, Takahiro; Ito, Yasuhiko; Maeda, Miho; Fukunaga, Yoshitaka


    Acute megakaryoblastic leukemia (AML M7) is a biologically heterogeneous form of acute myeloid leukemia accounting for 14.6% of cases. In many instances in the past, AML M7 has been classified as undifferentiated leukemia, myelodysplasia, myelofibrosis or some other disease because of its complex clinical presentation or the difficulty of obtaining and interpreting bone marrow samples. However, with currently available morphological, cytochemical, cytogenetic and immunophenotypic methods, AML M7 can now be reliably diagnosed. Although the radiographic spectrum of bony changes in leukemia have been well characterized, skeletal X-ray abnormalities in the setting of AML M7 in pediatric patients have been described in few reports that were associated with bone marrow fibrosis. Here we report on a 14-month-old girl who presented with a massive periosteal reaction of the extremities and clavicles associated with myelofibrosis, a presenting feature of AML M7. The bone changes were very unusual in this case.

  14. Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine (United States)

    Ouzon-Shubeita, Hala; Lee, Seongmin


    N7-Methyl-2′-deoxyguanosine (m7dG) is the predominant lesion formed by methylating agents. A systematic investigation on the effect of m7dG on DNA replication has been difficult due to the chemical instability of m7dG. To gain insights into the m7dG effect, we employed a 2′-fluorine-mediated transition-state destabilzation strategy. Specifically, we determined kinetic parameters for dCTP insertion opposite a chemically stable m7dG analogue, 2′-fluoro-m7dG (Fm7dG), by human DNA polymerase β (polβ) and solved three X-ray structures of polβ in complex with the templating Fm7dG paired with incoming dCTP or dTTP analogues. The kinetic studies reveal that the templating Fm7dG slows polβ catalysis ∼300-fold, suggesting that m7dG in genomic DNA may impede replication by some DNA polymerases. The structural analysis reveals that Fm7dG forms a canonical Watson–Crick base pair with dCTP, but metal ion coordination is suboptimal for catalysis in the polβ-Fm7dG:dCTP complex, which partially explains the slow insertion of dCTP opposite Fm7dG by polβ. In addition, the polβ-Fm7dG:dTTP structure shows open protein conformations and staggered base pair conformations, indicating that N7-methylation of dG does not promote a promutagenic replication. Overall, the first systematic studies on the effect of m7dG on DNA replication reveal that polβ catalysis across m7dG is slow, yet highly accurate. PMID:24966350

  15. The odds of a seismic source near Dwarka, NW Gujarat: An evaluation based on proxies

    Digital Repository Service at National Institute of Oceanography (India)

    Rajendran, C.P.; Rajendran, K.; Vora, K.H.; Gaur, A

    The Kachchh–Saurashtra region is part of an old rift basin, featuring a number of linear structures, some of them holding potential for occasional M > 7 earthquakes. A challenging question is to identify probable sources of large earthquakes...

  16. February 2011 Christchurch, New Zealand Images (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The South Island, New Zealand earthquake occurred as part of the aftershock sequence of the M 7.0 September 3, 2010 Darfield, NZ earthquake. It involved...

  17. The effects of annealing temperature and cooling rate on carbide precipitation behavior in H13 hot-work tool steel

    International Nuclear Information System (INIS)

    Kang, Minwoo; Park, Gyujin; Jung, Jae-Gil; Kim, Byung-Hoon; Lee, Young-Kook


    Highlights: • Unexpected Mo carbides formed during slow cooling from low annealing temperatures. • Mo carbides formed during the migration of Mo for a transition of Cr-rich carbide. • Mo carbides were precipitated at the boundaries of M 7 C 3 carbides and ferrite grains. • Annealing conditions for the precipitation of Mo carbides were discussed. - Abstract: The precipitation behavior of H13 hot-work tool steel was investigated as a function of both annealing temperature and cooling rate through thermodynamic calculations and microstructural analyses using transmission and scanning electron microscope and a dilatometer. The V-rich MC carbide and Cr-rich M 7 C 3 and M 23 C 6 carbides were observed in all annealed specimens regardless of annealing and cooling conditions, as expected from an equilibrium phase diagram of the steel used. However, Mo-rich M 2 C and M 6 C carbides were unexpectedly precipitated at a temperature between 675 °C and 700 °C during slow cooling at a rate of below 0.01 °C/s from the annealing temperatures of 830 °C and below. The solubility of Mo in both M 7 C 3 and ferrite reduces with decreasing temperature during cooling. Mo atoms diffuse out of both M 7 C 3 and ferrite, and accumulate locally at the interface between M 7 C 3 and ferrite. Mo carbides were form at the interface of M 7 C 3 carbides during the transition of Cr-rich M 7 C 3 to stable M 23 C 6

  18. AdS3/CFT2, finite-gap equations and massless modes

    International Nuclear Information System (INIS)

    Lloyd, Thomas; Stefański, Bogdan Jr.


    It is known that string theory on AdS 3 ×M 7 backgrounds, where M 7 =S 3 ×S 3 ×S 1 or S 3 ×T 4 , is classically integrable. This integrability has been previously used to write down a set of integral equations, known as the finite-gap equations. These equations can be solved for the closed string spectrum of the theory. However, it has been known for some time that the finite-gap equations on these AdS 3 ×M 7 backgrounds do not capture the dynamics of the massless modes of the closed string theory. In this paper we re-examine the derivation of the AdS 3 ×M 7 finite-gap system. We find that the conditions that had previously been imposed on these integral equations in order to implement the Virasoro constraints are too strict, and are in fact not required. We identify the correct implementation of the Virasoro constraints on finite-gap equations and show that this new, less restrictive condition captures the complete closed string spectrum on AdS 3 ×M 7

  19. Effect of Ti additive on (Cr, Fe)7C3 carbide in arc surfacing layer and its refined mechanism

    International Nuclear Information System (INIS)

    Zhou Yefei; Yang Yulin; Yang Jian; Hao Feifei; Li Da; Ren Xuejun; Yang Qingxiang


    Arc surfacing layer of hypoeutectic high chromium cast iron (HCCI) expects refiner carbides in the microstructure to improve its mechanical properties. In this paper, Ti additive as a strong carbide forming element was added in the hypoeutectic HCCI arc surfacing layer. Microstructure of titaniferous hypoeutectic HCCI was studied by optical microscopy, X-ray diffraction and field emission scanning electronic microscopy with energy dispersive spectrometer. Furthermore, the M(M = Cr, Fe) 7 C 3 carbide refinement mechanism was explained by the phase diagram calculation and lattice misfit theory. The results show that, the M 7 C 3 carbide in arc surfacing microstructure of hypoeutectic HCCI has been refined with 2 wt.% Ti additive, and TiC carbide can be observed in/around the M 7 C 3 carbide. With Ti addictive increasing, the micro-hardness along the depth in profile section of layer becomes more uniform, and the wear resistance has been improved. According to the phase diagram calculation, MC carbide precipitates prior to M 7 C 3 carbide in Fe-Cr-C-Ti alloy. In addition, the lattice misfit between (1 1 0) TiC and (010) Cr 7 C 3 is 9.257%, which indicates that the TiC as heterogeneous nuclei of the M 7 C 3 is medium effective. Therefore, the M 7 C 3 carbide can be refined.

  20. Yeast endoribonuclease stimulated by Novikoff Hepatoma small nuclear RNAS U1 and U2

    International Nuclear Information System (INIS)

    Stevens, A.


    Using [ 3 H]m 7 Gppp[ 14 C]RNA-poly(A) from yeast as a substrate, an endoribonuclease has been detected in enzyme fractions derived from a high salt wash of ribonucleoprotein particles of Saccharomyces cerevisiae. The [ 3 H]m 7 Gppp[ 14 C]RNA-poly(A) seems to be a preferred substrate since other polyribonucleotides are hydrolyzed more slowly, if at all. The enzyme is inhibited by ethidium bromide, but fully double-stranded polyribonucleotides are not hydrolyzed. The hydrolysis of [ 3 H]m 7 Gppp[ 14 C]RNA-poly(A) is stimulated about 2.5-fold by the addition of small nuclear RNAs U1 and U2 of Novikoff hepatoma cells. Results show that the stimulation involves an interaction of the labeled RNA with the small nuclear RNA

  1. A yeast endoribonuclease stimulated by Novikoff hepatoma small nuclear RNAs U1 and U2

    International Nuclear Information System (INIS)

    Stevens, A.


    Using [ 3 H]m 7 Gppp[ 14 C]RNA-poly(A) from yeast as a substrate, an endoribonuclease has been detected in enzyme fractions derived from a high salt wash of ribonucleoprotein particles of Saccharomyces cerevisiae. The [ 3 H]m 7 Gppp[ 14 C]RNA-poly(A) seems to be a preferred substrate since other polyribonucleotides are hydrolyzed more slowly, if at all. The enzyme is inhibited by ethidium bromide, but fully double-stranded polyribonucleotides are not hydrolyzed. The hydrolysis of [ 3 H]m 7 Gppp[ 14 C]RNA-poly(A) is stimulated about 2.5-fold by the addition of small nuclear RNAs U1 and U2 of Novikoff hepatoma cells. Results show that the stimulation involves an interaction of the labeled RNA with the small nuclear RNA

  2. Translational recognition of the 5'-terminal 7-methylguanosine of globin messenger RNA as a function of ionic strength. (United States)

    Chu, L Y; Rhoads, R E


    The translation of rabbit globin mRNA in cell-free systems derived from either wheat germ or rabbit reticulocyte was studied in the presence of various analogues of the methylated 5' terminus (cap) as a function of ionic strength. Inhibition by these analogues was strongly enhanced by increasing concentrations of KCl, K(OAc), Na(OAc), or NH4(OAc). At appropriate concentrations of K(OAc), both cell-free systems were equally sensitive to inhibition by m7GTP. At 50 mM K(OAc), the reticulocyte system was not sensitive to m7GMP or m7GTP, but at higher concentrations up to 200 mM K(OAc), both nucleotides caused strong inhibition. The compound in m7G5'ppp5'Am was inhibitory at all concentrations of K(OAc) ranging from 50 to 200 mM, although more strongly so at the higher concentrations. Over the same range of nucleotide concentrations, the compounds GMP, GTP, and G5'ppp5'Am were not inhibitors. The mobility on sodium dodecyl sulfate-polyacrylamide electrophoresis of the translation product was that of globin at all K(OAc) concentrations in the presence of m7GTP. Globin mRNA from which the terminal m7GTP group had been removed by chemical treatment (periodate-cyclohexylamine-alkaline phosphatase) or enzymatic treatment (tobacco acid pyrophosphatase-alkaline phosphatase) was translated less efficiently than untreated globin mRNA at higher K(OAc) concentrations, but retained appreciable activity at low K(OAc) concentrations.

  3. Effect of Titanium on the Microstructure and Mechanical Properties of High-Carbon Martensitic Stainless Steel 8Cr13MoV


    Wen-Tao Yu; Jing Li; Cheng-Bin Shi; Qin-Tian Zhu


    The effect of titanium on the carbides and mechanical properties of martensitic stainless steel 8Cr13MoV was studied. The results showed that TiCs not only acted as nucleation sites for δ-Fe and eutectic carbides, leading to the refinement of the microstructure, but also inhibited the formation of eutectic carbides M7C3. The addition of titanium in steel also promoted the transformation of M7C3-type to M23C6-type carbides, and consequently more carbides could be dissolved into the matrix duri...

  4. Land Use Control Implementation Plan (United States)

    Starr, Andrew Scott


    This Land Use Control Implementation Plan (LUCIP) has been prepared to inform current and potential future users of Building M7-505 of institutional controls that have been implemented at the site. Although there are no current unacceptable risks to human health or the environment associated with Building M7-505, institutional land use controls (LUCs) are necessary to prohibit the use of groundwater from the site. LUCs are also necessary to prevent access to soil under electrical equipment in the northwest portion of the site. Controls necessary to prevent human exposure will include periodic inspection, condition certification, and agency notification.

  5. Dlk1 in normal and abnormal hematopoiesis

    DEFF Research Database (Denmark)

    Sakajiri, S; O'kelly, J; Yin, D


    normals. Also, Dlk1 mRNA was elevated in mononuclear, low density bone marrow cells from 11/38 MDS patients, 5/11 AML M6 and 2/4 AML M7 samples. Furthermore, 5/6 erythroleukemia and 2/2 megakaryocytic leukemia cell lines highly expressed Dlk1 mRNA. Levels of Dlk1 mRNA markedly increased during...... (particularly M6, M7), and it appears to be associated with normal development of megakaryocytes and B cells....

  6. 中国における地盤災害-特に液状化について*


    劉, 頴


    China is a great country with broad territory and has a long history within which earthquakes fre-quently occurred. In our historical documents there are records of sand boils induced by earthquakes, since about one thousand years ago. After the founding of new China, many disastrous earthquakes haveoccurred, such as the 1966 Xingtai earthquake (M=6.8 and 7.2), the 1975 Haiching earthquake (M=7.3)and the 1976 Tangshan earthquake (M=7.8 and 7.1). In these earthquakes, sand liquefaction occurre...

  7. [Effects of nitrogen-supply levels on leaf senescence and characteristics of distribution and utilization of 13C and 15N in Fuji 3 apple grafted on different stocks]. (United States)

    Chen, Qian; Ding, Ning; Zhu, Zhan Ling; Peng, Ling; Ge, Shun Feng; Jiang, Yuan Mao


    Two-year-old potted Fuji 3 apple trees on different rootstocks [Fuji 3/M. micromalus Makin (joe), Fuji 3/M7 (semi-dwarf) and Fuji 3/M26/M. micromalus Makin (dwarf)] were used to study leaf morphology and photosynthesis and the characteristics of distribution and utilization of 13 C and 15 N at different nitrogen supply levels (0N, 25%N and 100%N, the N content in 100% N treatment was the same as that in Hoagland complete nutrient solution) under sand culture condition. The main results were as follows: At shoot growth cessation stage in autumn, the leaf chlorophyll content (SPAD), leaf nitrogen content and photosynthetic rate were found the highest in Fuji 3/M. micromalus Makin, followed by Fuji 3/M7, and the lowest was found in Fuji 3/M26/M. micromalus Makin under the same nitrogen stress treatments (0N and 25%N), however, under normal nitrogen treatment (100%N) Fuji 3/M26/M. micromalus Makin had the highest leaf SPAD value, photosynthetic rate and the nitrogen content, followed by Fuji 3/M7, and the lowest was found in Fuji 3/M. micromalus Makin. The leaf SOD and CAT activities showed Fuji 3/M. micromalus Makin > Fuji 3/M7 > Fuji 3/M26/M. micromalus Makin under the same nitrogen stress treatments, but showed Fuji 3/M26/M. micromalus Makin > Fuji 3/M7 > Fuji 3/M. micromalus Makin under the normal nitrogen treatment. There were significant differences in the distributions of 15 N and 13 C in root and leaf in the 3 scion-stock combinations, and the distribution rates of 15 N and 13 C in roots were the highest under nitrogen stress treatments and in the order of Fuji 3/M. micromalus Makin > Fuji 3/M7 > Fuji 3/M26/M. micromalus Makin. The distribution rates of 15 N and 13 C in leaves were the highest under the normal nitrogen treatment and in the order of Fuji 3/M26/M. micromalus Makin > Fuji 3/M7 > Fuji 3/M. micromalus Makin. The 15 N utilization ratio differed significantly among the 3 scion-stock combinations under different nitrogen application levels and was in

  8. mRNA decapping enzyme from ribosomes of Saccharomyces cerevisiae

    International Nuclear Information System (INIS)

    Stevens, A.


    By use of [ 3 H]methyl-5'-capped [ 14 C]mRNA from yeast as a substrate, a decapping enzyme activity has been detected in enzyme fractions derived from a high salt wash of ribosomes of Saccharomyces cerevisiae. The product of the decapping reaction is [ 3 H]m 7 GDP. That the enzyme is not a non-specific pyrophosphatase is suggested by the finding that the diphosphate product, m 7 GpppA(G), and UDP-glucose are not hydrolyzed

  9. Results from Second Round of Remediated Nitrate Salt Surrogate Formulation and Testing

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Geoffrey Wayne [Los Alamos National Laboratory; Leonard, Philip [Los Alamos National Laboratory; Hartline, Ernest Leon [Los Alamos National Laboratory; Tian, Hongzhao [Los Alamos National Laboratory


    High Explosives and Technology (M-7) completed the second round of formulation and testing of Remediated Nitrate Salt (RNS) surrogates on March 17, 2016. This report summarizes the results of the work and also includes additional documentation required under test plan PLAN-TA9-2443 Rev B, "Remediated Nitrate Salt (RNS) Surrogate Formulation and Testing Standard Procedure", released February 16, 2016. All formulation and testing was carried out according to PLAN-TA9-2443 Rev B. Results from the first round of formulation and testing were documented in memorandum M7-16-6042, "Results from First Round of Remediated Nitrate Salt Surrogate Formulation and Testing."

  10. Land Based Environmental Monitoring at Johnston Island - Disposal of Herbicide Orange (United States)


    Allizan fistuloswon p Welsh onion Allium sp. P Chives Aloe sp. P * Aloe Cordyline fruticosa p Cordyline Sansevicria tirifaciata r Bowstring Hecmp Vow...Beanf M7 52 TABLE 15. (Continued) Island s Family Sand Species John- Sand Man- Common Name Akau Hikina ston Orig. made Leguminosae (cont.) Piswn sativum p

  11. Developing soccer coaches in South Africa through mentoring ...

    African Journals Online (AJOL)

    This investigation was undertaken to establish soccer coaches' views and experiences with regard to mentoring as a way of developing their skills and knowledge. The authors conducted a qualitative phenomenological study with seven purposively selected participants (coded as M1 – M7) who were involved in soccer ...

  12. 75 FR 51291 - National Science Board: Sunshine Act Meetings; Notice (United States)


    ... Engineering Indicators 2012. Introduction of Chapter Authors and Discussion of Science and Engineering.... Introduction of Chapter Authors and Discussion of Science and Engineering Indicators 2012. Narrative Chapter... Chairman's Introduction Open Session: 7:30 a.m.-7:35 a.m., Room 1235 Committee on Programs and Plans (CPP...

  13. 78 FR 25769 - Notice of Meeting; Advisory Committee on Reactor Safeguards (United States)


    ... Containments to Early Failure from Hydrogen Combustion during a Severe Accident'' (Open)--The Committee will... Combustion during a Severe Accident.'' 4:45 p.m.-7:00 p.m.: Preparation of ACRS Reports (Open)--The Committee...

  14. An application of earthquake prediction algorithm M8 in eastern ...

    Indian Academy of Sciences (India)

    2Institute of Earthquake Prediction Theory and Mathematical Geophysics, ... located about 70 km from a preceding M7.3 earthquake that occurred in ... local extremes of the seismic density distribution, and in the third approach, CI centers were distributed ...... Bird P 2003 An updated digital model of plate boundaries;.

  15. Three duplication events and variable molecular evolution ...

    Indian Academy of Sciences (India)

    2Staff Development Institute of CNTC, Zhengzhou, Henan 450008, People's Republic of China .... more strict selective constraint than others and none of high ω value ... (2007) description, M1a versus M2a is less power than M7 ... We failed to.

  16. 78 FR 34573 - Special Local Regulations; Safety Zones; Recurring Events in Captain of the Port Long Island... (United States)


    ... Yacht Date: July 6, 2013. Club Fireworks. Rain date: July 7, 2013. Time: 8:30 p.m. to 10:00 p.m...). 7.35 Groton Long Point Yacht Date: July 20, 2013. Club Fireworks. Rain date: July 21, 2013. Time: 9...


    DEFF Research Database (Denmark)

    Ucar, Hülya; Nielsen, Rudi Pankratz; Søgaard, Erik Gydesen

    A solvolysis process to depolymerize the resin in glass fiber reinforced composites and recover the glass fibers has been investigated using microwave induced irradiation. The depolymerization was carried out in HNO3 with concentrations in the range of 1M-7M and in KOH with concentrations ranging...

  18. 75 FR 4589 - National Science Board; Sunshine Act Meetings; Notice (United States)


    ... DISCUSSED: Wednesday, February 3, 2010 Chairman's Introduction Open Session: 7:30 a.m.-7:35 a.m., Room 1235... Research. NSB Action Item: Award for NEON: Observatory Design and Prototyping. Committee on Strategy and.... Financial System Modernization--``iTRAK''. Inspector General's ARRA Update. Closed Investigative Matters...

  19. 75 FR 35024 - North Carolina Waters Along the Entire Length of Brunswick and Pender Counties and the Saline... (United States)


    ... Marina, 910-458-0575, Flexible-open year round, 4' draft at mean low tide (6) Waterfront Village & Yacht...:30 p.m. Monday-Friday, 13'-18' draft at mean low tide (13) Seapath Yacht Club, 910-256-3747, 7 a.m.-7...

  20. 77 FR 18268 - Proposal Review Panel for Engineering Education and Centers; Notice of Meeting (United States)


    ... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Engineering Education and Centers; Notice of... Science Foundation announces the following meeting: Name: Proposal Review Panel for Engineering Education...--ERC Research Program 3:30 p.m.--7:30 p.m. Closed--ERC Education Program Thursday, March 29, 2012 8 a.m...

  1. Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia.

    NARCIS (Netherlands)

    Tischkowitz, M; Ameziane, N.; Waisfisz, Q.; Winter, de J.P.; Harris, R; Taniguchi, T; Andrea, d' A; Hodgson, SV; Mathew, C.G.; Joenje, H.


    Fanconi anaemia (FA) is a chromosomal instability disorder associated with a high risk of acute myeloid leukaemia (AML). Previous work has shown that the AML cell line CHRF-288, derived from a sporadic AML-M7 patient, does not express FANCF protein and exhibits a cellular FA phenotype. We show that

  2. Assigning probability gain for precursors of four large Chinese earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Cao, T.; Aki, K.


    We extend the concept of probability gain associated with a precursor (Aki, 1981) to a set of precursors which may be mutually dependent. Making use of a new formula, we derive a criterion for selecting precursors from a given data set in order to calculate the probability gain. The probabilities per unit time immediately before four large Chinese earthquakes are calculated. They are approximately 0.09, 0.09, 0.07 and 0.08 per day for 1975 Haicheng (M = 7.3), 1976 Tangshan (M = 7.8), 1976 Longling (M = 7.6), and Songpan (M = 7.2) earthquakes, respectively. These results are encouraging because they suggest that the investigated precursory phenomena may have included the complete information for earthquake prediction, at least for the above earthquakes. With this method, the step-by-step approach to prediction used in China may be quantified in terms of the probability of earthquake occurrence. The ln P versus t curve (where P is the probability of earthquake occurrence at time t) shows that ln P does not increase with t linearly but more rapidly as the time of earthquake approaches.

  3. Memory Abilities in Children with Mathematical Difficulties: Comorbid Language Difficulties Matter (United States)

    Reimann, Giselle; Gut, Janine; Frischknecht, Marie-Claire; Grob, Alexander


    The present study investigated cognitive abilities in children with difficulties in mathematics only (n = 48, M = 8 years and 5 months), combined mathematical and language difficulty (n = 27, M = 8 years and 1 month) and controls (n = 783, M = 7 years and 11 months). Cognitive abilities were measured with seven subtests, tapping visual perception,…

  4. Asteroseismology of 16,000 Kepler Red Giants

    DEFF Research Database (Denmark)

    Yu, Jie; Huber, Daniel; Bedding, Timothy R.


    (sigma(M) = 7.8%), radius (sigma(R) = 2.9%), and thus surface gravity (sigma(log g) = 0.01 dex). Thanks to the large red giant sample, we confirm that red-giant-branch (RGB) and helium-core-burning (HeB) stars collectively differ in the distribution of oscillation amplitude, granulation power, and width...

  5. 24 - 28_Suleiman et al.

    African Journals Online (AJOL)


    from their constructed pits under trees within Biological .... *Pairs of treatments that are not significantly different from one another share the same letter a, b or c at 10% ... 4.5a. M. 7.9 b. 2.9 a. 4.9a. *Pairs of treatments that are not significantly different from one another share .... and luminance on predator foraging decision.

  6. Home and Parenting Resources Available to Siblings Depending on Their Birth Intention Status (United States)

    Barber, Jennifer S.; East, Patricia L.


    This study examines the differential availability of family and parenting resources to children depending on their birth planning status. The National Longitudinal Survey of Youth data were analyzed, 3,134 mothers and their 5,890 children (M = 7.1 years, range = 1 month-14.8 years), of whom 63% were intended at conception, 27% were mistimed, and…

  7. 75 FR 30105 - Petition for Waiver of Compliance (United States)


    ... requirements for testing locomotive horns. LIRR operates 836 M-7 MU passenger cars of which 84 have had their horns tested; and 170 M-3 MU passenger cars of which 60 have had their horns tested. In addition, LIRR operates 80 diesel electric locomotives of which 7 horns have been tested; and 23 control car locomotives...

  8. 77 FR 3329 - Injurious Wildlife Species; Listing Three Python Species and One Anaconda Species as Injurious... (United States)


    ... increase their genetic fitness and temperature tolerance as a result of natural selection pressures...) predator at the top of the food chain, they can threaten the stability of native ecosystems by altering the... conditions, pythons will grow very fast. After 1 year, a python may be 2 m (7 ft) and after 5 years it could...

  9. Genotypic variability in sesame mutant lines in Kenya | Ong'injo ...

    African Journals Online (AJOL)

    Sesame (Sesamum indicum L) is one of the major oil crops with potential for production by small- scale holders in the marginal agro-ecological zones of Kenya. Variability studies on yield and yield components of sesame mutant lines now in M7generation was carried out in two locations for two seasons in Kenya.

  10. Influence of pH and media composition on suspension stability of silver, zinc oxide, and titanium dioxide nanoparticles and immobilization of Daphnia magna under guideline testing conditions

    DEFF Research Database (Denmark)

    Cupi, Denisa; Hartmann, Nanna B.; Baun, Anders


    sterically stabilized, test suspensions of silver (Ag) ENPs formed large agglomerates in both VS EPA and M7 media; and toxicity was found to be higher in VS EPA medium due to increased dissolution. Low-agglomerate suspensions for zinc oxide (ZnO) could be obtained at pH 7 in VS EPA medium, but the increase...

  11. Dicty_cDB: AFO458 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available . 44 1.3 1 T09643 |T09643.1 0215m7 gmbPfHB3.1, G. Roman Reddy Plasmodium falciparum genomic clone 0215m, DNA... sequence. 38 1.5 2 AA550553 |AA550553.1 1716m3 gmbPfHB3.1, G. Roman Reddy Plasmodium falciparum genomic clo

  12. Dicty_cDB: VSD608 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available T09822 |T09822.1 0405m3 gmbPfHB3.1, G. Roman Reddy Plasmodium falciparum genomic ...clone 0405m, DNA sequence. 50 4e-07 2 T09823 |T09823.1 0405m7 gmbPfHB3.1, G. Roman Reddy Plasmodium falcipar

  13. Precipitation-hardening stainless steel bars, shapes, and forgings (ASME SA-564 with additional requirements)

    International Nuclear Information System (INIS)


    A standard prescribing requirements for precipitation-hardening stainless steel bars, shapes, and forgings (ASME SA-564 with additional requirements) for nuclear and associated applications is presented. This standard supersedes RDT M 7-6T, dated January 1974. (U.S.)

  14. Summary of Remediated Nitrate Salt Surrogate Formulation and Testing

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Geoffrey Wayne [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Leonard, Philip [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hartline, Ernest Leon [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Tian, Hongzhao [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    High Explosives Science and Technology (M-7) completed all required formulation and testing of Remediated Nitrate Salt (RNS) surrogates on April 27, 2016 as specified in PLAN-TA9-2443 Rev B, "Remediated Nitrate Salt (RNS) Surrogate Formulation and Testing Standard Procedure", released February 16, 2016. This report summarizes the results of the work and also includes additional documentation required in that test plan. All formulation and testing was carried out according to PLAN-TA9-2443 Rev B. The work was carried out in three rounds, with the full matrix of samples formulated and tested in each round. Results from the first round of formulation and testing were documented in memorandum M7-J6-6042, " Results from First Round of Remediated Nitrate Salt Surrogate Formulation and Testing." Results from the second round of formulation and testing were documented in M7-16-6053 , "Results from the Second Round of Remediated Nitrate Salt Surrogate Formulation and Testing." Initial results from the third round were documented in M7-16-6057, "Initial Results from the Third Round of Remediated Nitrate Salt Formulation and Testing."

  15. Gender Differences in Perceived Gratifications Obtained through Electronic Mail (United States)

    Harper, Vernon B., Jr.; Harper, Erika J.


    Electronic mail provides users with unique positive psychological consequences that differentiate it from other media. These consequences or gratifications have been mentioned separately across the electronic mail literature, yet there is no specific measure for these gratifications. The study found that females (M = 7.7; SD = 1.8) achieve higher…

  16. Optical Imaging of Matrix Metalloproteinase-7 Activity in Vivo Using a Proteolytic Nanobeacon

    Directory of Open Access Journals (Sweden)

    Randy L. Scherer


    Full Text Available Matrix metalloproteinases (MMPs are extracellular proteolytic enzymes involved in tumor progression. We present the in vivo detection and quantitation of MMP7 activity using a specific near-infrared polymer-based proteolytic beacon, PB-M7NIR. PB-M7NIR is a pegylated polyamidoamine PAMAM-Generation 4 dendrimer core covalently coupled to a Cy5.5-labeled peptide representing a selective substrate that monitors MMP7 activity (sensor and AF750 as an internal reference to monitor relative substrate concentration (reference. In vivo imaging of tumors expressing MMP7 had a median sensor to reference ratio 2.2-fold higher than a that of a bilateral control tumor. Ex vivo imaging of intestines of multiple intestinal neoplasia (APCMin mice injected systemically with PB-M7NIR revealed a sixfold increase in the sensor to reference ratio in the adenomas of APCMin mice compared with control intestinal tissue or adenomas from MMP7-null Min mice. PB-M7NIR detected tumor sizes as small as 0.01 cm2, and the sensor to reference ratio was independent of tumor size. Histologic sectioning of xenograft tumors localized the proteolytic signal to the extracellular matrix; MMP7-overexpressing tumors displayed an approximately 300-fold enhancement in the sensor to reference ratio compared with nonexpressing tumor cells. In APCMin adenomas, the proteolytic signal colocalized with the endogenously expressed MMP7 protein, with sensor to reference ratios approximately sixfold greater than that of normal intestinal epithelium. PB-M7NIR provides a useful reagent for the in vivo and ex vivo quantitation and localization of MMP-selective proteolytic activity.

  17. Influence of pH and media composition on suspension stability of silver, zinc oxide, and titanium dioxide nanoparticles and immobilization of Daphnia magna under guideline testing conditions. (United States)

    Cupi, Denisa; Hartmann, Nanna B; Baun, Anders


    In aquatic toxicity testing of engineered nanoparticles (ENPs) the process of agglomeration is very important as it may alter bioavailability and toxicity. In the present study, we aimed to identify test conditions that are favorable for maintaining stable ENP suspensions. We evaluated the influence of key environmental parameters: pH (2-12) and ionic strength using M7, Soft EPA (S EPA) medium, and Very Soft EPA (VS EPA) medium; and observed the influence of these parameters on zeta potential, zeta average, and acute immobilization of Daphnia magna for three different ENPs. Despite being sterically stabilized, test suspensions of silver (Ag) ENPs formed large agglomerates in both VS EPA and M7 media; and toxicity was found to be higher in VS EPA medium due to increased dissolution. Low-agglomerate suspensions for zinc oxide (ZnO) could be obtained at pH 7 in VS EPA medium, but the increase in dissolution caused higher toxicity than in M7 medium. Titanium dioxide (TiO2) ENPs had a point of zero charge in the range of pH 7-8. At pH 7 in VS EPA, agglomerates with smaller hydrodynamic diameters (~200nm) were present compared to the high ionic strength M7 medium where hydrodynamic diameters reached micrometer range. The stable suspensions of TiO2 ENPs caused immobilization of D. magna, 48-h EC50 value of 13.7mgL(-1) (95% CI, 2.4mg-79.1mgL(-1)); whereas no toxicity was seen in the unstable, highly agglomerated M7 medium suspensions, 48-h EC50 >100mgL(-1). The current study provides a preliminary approach for methodology in testing and assessing stability and toxicity of ENPs in aquatic toxicity tests of regulatory relevance. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. A high resolution 3D velocity model beneath the Tokyo Metropolitan area by MeSO-net (United States)

    Nakagawa, S.; Sakai, S.; Honda, R.; Kimura, H.; Hirata, N.


    Beneath the Tokyo metropolitan area, the Philippine Sea Plate (PSP) subducts and causes devastating mega-thrust earthquakes, such as the 1703 Genroku earthquake (M8.0) and the 1923 Kanto earthquake (M7.9). An M7 or greater (M7+) earthquake in this area at present has high potential to produce devastating serious loss of life and property with even greater global economic repercussions. The Central Disaster Management Council of Japan estimates that an M7+ earthquake will cause 23,000 fatalities and 95 trillion yen (about 1 trillion US$) economic loss. We have launched the Special Project for Reducing Vulnerability for Urban Mega Earthquake Disasters in collaboration with scientists, engineers, and social-scientists in nationwide institutions since 2012. We analyze data from the dense seismic array called Metropolitan Seismic Observation network (MeSO-net), which has 296 seismic stations with spacing of 5 km (Sakai and Hirata, 2009; Kasahara et al., 2009). We applied the double-difference tomography method (Zhang and Thurber, 2003) and estimated the velocity structure and the upper boundary of PSP (Nakagawa et al., 2010). The 2011 Tohoku-oki earthquake (M9.0) has activated seismicity also in Kanto region, providing better coverage of ray paths for tomographic analysis. We obtain much higher resolution velocity models from whole dataset observed by MeSO-net between 2008 and 2015. A detailed image of tomograms shows that PSP contacts Pacific plate at a depth of 50 km beneath northern Tokyo bay. A variation of velocity along the oceanic crust suggests dehydration reaction to produce seismicity in a slab, which may related to the M7+ earthquake. Acknowledgement: This study was supported by the Special Project for Reducing Vulnerability for Urban Mega Earthquake Disasters of MEXT, Japan and the Earthquake Research Institute cooperative research program.


    Directory of Open Access Journals (Sweden)



    Full Text Available Verifica-se, a nível mundial, uma forte tendência para o plantio da macieira em alta densidade de cultivo. Neste sistema de plantio, são utilizados porta-enxertos de pequeno porte, conhecidos como anões. O mais utilizado é o M-9, em virtude do forte controle sobre o porte da copa, da precocidade de produção, da alta produtividade e da boa qualidade dos frutos que induz à copa. No Sul do Brasil, por questões de tradição internacional, facilidade de obtenção e do menor custo de investimento no plantio, até recentemente, têm sido plantados porta-enxertos de vigor médio, como o MM-106, o M-7 e o MM-111, para plantios de média densidade. O primeiro é atualmente pouco usado devido à alta suscetibilidade à podridão-do-colo (Phytophthora cactorum. O objetivo deste trabalho foi comparar o desempenho do anão M-9, do semi-anão M-7 e do semivigoroso MM-111 no controle do vigor da copa, na precocidade de produção, na produtividade e no tamanho dos frutos da cv. de macieira Fuji. O experimento foi conduzido em blocos ao acaso, com 4 repetições de 3 plantas por parcela. Como copa, foi utilizada a cv. Fuji, polinizada pela cv. Gala. O experimento foi implantado em 1996, em Fraiburgo-SC, principal pólo produtor de maçãs do País. O espaçamento de cultivo foi de 2,0 m por 5,0 m. O experimento foi conduzido por 4 anos, avaliando-se a precocidade (n0 de gemas de flor/cm² de área transversal do caule, produção (kg/planta, produtividade (t/ha, peso médio dos frutos (g e distribuição dos frutos por categoria de tamanho (%. Os resultados obtidos indicaram que o M-9 foi o mais precoce, produzindo, no terceiro ano, 1,94 vez mais gemas de flor que o M-7 e 2,70 vezes mais que o MM-111. Em termos de produção, no terceiro ano, o M-9 produziu 2,53 vezes mais que o M-7 e 2,70 vezes mais que o MM-111. No quarto ano, o M-9 produziu 1,28 vez mais que o M-7 e 1,26 vez mais que o MM-111. O peso médio dos frutos foi de 159,2 g, 135,5 g e 131

  20. Development of an ELISA assay for screening inhibitors against divalent metal ion dependent alphavirus capping enzyme. (United States)

    Kaur, Ramanjit; Mudgal, Rajat; Narwal, Manju; Tomar, Shailly


    Alphavirus non-structural protein, nsP1 has a distinct molecular mechanism of capping the viral RNAs than the conventional capping mechanism of host. Thus, alphavirus capping enzyme nsP1 is a potential drug target. nsP1 catalyzes the methylation of guanosine triphosphate (GTP) by transferring the methyl group from S-adenosylmethionine (SAM) to a GTP molecule at its N7 position with the help of nsP1 methyltransferase (MTase) followed by guanylylation (GT) reaction which involves the formation of m 7 GMP-nsP1 covalent complex by nsP1 guanylyltransferase (GTase). In subsequent reactions, m 7 GMP moiety is added to the 5' end of the viral ppRNA by nsP1 GTase resulting in the formation of cap0 structure. In the present study, chikungunya virus (CHIKV) nsP1 MTase and GT reactions were confirmed by an indirect non-radioactive colorimetric assay and western blot assay using an antibody specific for the m 7 G cap, respectively. The purified recombinant CHIKV nsP1 has been used for the development of a rapid and sensitive non-radioactive enzyme linked immunosorbent assay (ELISA) to identify the inhibitors of CHIKV nsP1. The MTase reaction is followed by GT reaction and resulted in m 7 GMP-nsP1 covalent complex formation. The developed ELISA nsP1 assay measures this m 7 GMP-nsP1 complex by utilizing anti-m 7 G cap monoclonal antibody. The mutation of a conserved residue Asp63 to Ala revealed its role in nsP1 enzyme reaction. Inductively coupled plasma mass spectroscopy (ICP-MS) was used to determine the presence of magnesium ions (Mg 2+ ) in the purified nsP1 protein. The divalent metal ion selectivity and investigation show preference for Mg 2+ ion by CHIKV nsP1. Additionally, using the developed ELISA nsP1 assay, the inhibitory effects of sinefungin, aurintricarboxylic acid (ATA) and ribavirin were determined and the IC 50 values were estimated to be 2.69 µM, 5.72 µM and 1.18 mM, respectively. Copyright © 2018. Published by Elsevier B.V.

  1. Earthquake Loss Scenarios in the Himalayas (United States)

    Wyss, M.; Gupta, S.; Rosset, P.; Chamlagain, D.


    We estimate quantitatively that in repeats of the 1555 and 1505 great Himalayan earthquakes the fatalities may range from 51K to 549K, the injured from 157K to 1,700K and the strongly affected population (Intensity≥VI) from 15 to 75 million, depending on the details of the assumed earthquake parameters. For up-dip ruptures in the stressed segments of the M7.8 Gorkha 2015, the M7.9 Subansiri 1947 and the M7.8 Kangra 1905 earthquakes, we estimate 62K, 100K and 200K fatalities, respectively. The numbers of strongly affected people we estimate as 8, 12, 33 million, in these cases respectively. These loss calculations are based on verifications of the QLARM algorithms and data set in the cases of the M7.8 Gorkha 2015, the M7.8 Kashmir 2005, the M6.6 Chamoli 1999, the M6.8 Uttarkashi 1991 and the M7.8 Kangra 1905 earthquakes. The requirement of verification that was fulfilled in these test cases was that the reported intensity field and the fatality count had to match approximately, using the known parameters of the earthquakes. The apparent attenuation factor was a free parameter and ranged within acceptable values. Numbers for population were adjusted for the years in question from the latest census. The hour of day was assumed to be at night with maximum occupation. The assumption that the upper half of the Main Frontal Thrust (MFT) will rupture in companion earthquakes to historic earthquakes in the down-dip half is based on the observations of several meters of displacement in trenches across the MFT outcrop. Among mitigation measures awareness with training and adherence to construction codes rank highest. Retrofitting of schools and hospitals would save lives and prevent injuries. Preparation plans for helping millions of strongly affected people should be put in place. These mitigation efforts should focus on an approximately 7 km wide strip along the MFT on the up-thrown side because the strong motions are likely to be doubled. We emphasize that our estimates

  2. Coercive force changes in Sm(CoFeCuZr)z during step-like heat treatments

    International Nuclear Information System (INIS)

    Puzanova, T.Z.; Shchegoleva, N.N.; Sakhnova, L.V.; Majkov, V.G.; Shur, Ya.S.; Nikolaeva, N.V.


    Sm(Co 0.67 Fe 0.22 Cu 0.08 Zr 0.03 ) 8.35 alloy, contaning two homogeneous solid solutions SmM 6.85 and SmM 7.75 (M=Co, Fe, Cu, Zr) after high-temperature treatment, is investigated. It is shown, that after isothermal tempering at 800 deg C, SmM 6.85 and SmM 7.75 are close by microstructure and their coercive forces change in a different way during step-like cooling within 700-400 deg C interval. Possibility of producing material, single-phase in magnetic relation, is discussed

  3. New characteristics of intensity assessment of Sichuan Lushan "4.20" M s7.0 earthquake (United States)

    Sun, Baitao; Yan, Peilei; Chen, Xiangzhao


    The post-earthquake rapid accurate assessment of macro influence of seismic ground motion is of significance for earthquake emergency relief, post-earthquake reconstruction and scientific research. The seismic intensity distribution map released by the Lushan earthquake field team of the China Earthquake Administration (CEA) five days after the strong earthquake ( M7.0) occurred in Lushan County of Sichuan Ya'an City at 8:02 on April 20, 2013 provides a scientific basis for emergency relief, economic loss assessment and post-earthquake reconstruction. In this paper, the means for blind estimation of macroscopic intensity, field estimation of macro intensity, and review of intensity, as well as corresponding problems are discussed in detail, and the intensity distribution characteristics of the Lushan "4.20" M7.0 earthquake and its influential factors are analyzed, providing a reference for future seismic intensity assessments.

  4. Agronomic behavior of pseudo cereals genotypes subjected to drought and salinity conditions

    International Nuclear Information System (INIS)

    Cruz T, E. De la; Garcia A, J.M.; Gonzalez R, B.; Laguna C, A.


    With the purpose of evaluating the response to the salinity and drought of 7 genotypes of pseudo cereals that include to the variety of quinua Barandales (M7-0) and to the lines obtained by the radioinduced mutagenesis ININ 110 and ININ 333, two collections of red chia (Opopeo and Huiramangaro) and two collections of 'Huauzontle' of Atlacomulco (H1 and H3), were evaluated under a factorial experimental design two levels of humidity: normal watering and drought and three salinity levels 0, 50 and 100 mMhos. It was found a bigger yield in grams by plant in the drought subjected material (without salinity) and a bigger tolerance to the salinity in the genotypes H3, ININ M7-0, and ININ 110, exhibiting the 'Chia red' bigger susceptibility to the evaluated factors. (Author)

  5. Effects of Light Intensity and Color on the Biomass, Extracellular Red Pigment, and Citrinin Production of Monascus ruber. (United States)

    Wang, Liling; Dai, Yang; Chen, Wanping; Shao, Yanchun; Chen, Fusheng


    Light is a crucial environmental signal for fungi. In this work, the effects of different light intensities and colors on biomass, Monascus pigments (MPs) and citrinin production of Monascus ruber M7 were investigated. We have demonstrated that low intensity of blue light (500 lx) decreased Monascus biomass, increased MPs accumulation via upregulation of MpigA, MpigB, and MpigJ genes expression, but had no significant influence on citrinin production. High intensity of blue light (1500 lx) decreased citrinin accumulation but had no significant influence on biomass and MPs production after 14 days cultivation. Low intensity of green light (500 lx) stimulated citrinin production via upregulation of pksCT, mrl1, mrl2, and ctnA genes expression. One putative red light photoreceptor and two putative green light photoreceptors were identified in M. ruber M7. These observations will not only guide the practical production of Monascus but also contribute to our understanding light effects on Monascus.

  6. Effect of Titanium on the Microstructure and Mechanical Properties of High-Carbon Martensitic Stainless Steel 8Cr13MoV

    Directory of Open Access Journals (Sweden)

    Wen-Tao Yu


    Full Text Available The effect of titanium on the carbides and mechanical properties of martensitic stainless steel 8Cr13MoV was studied. The results showed that TiCs not only acted as nucleation sites for δ-Fe and eutectic carbides, leading to the refinement of the microstructure, but also inhibited the formation of eutectic carbides M7C3. The addition of titanium in steel also promoted the transformation of M7C3-type to M23C6-type carbides, and consequently more carbides could be dissolved into the matrix during hot processing as demonstrated by the determination of extracted carbides from the steel matrix. Meanwhile, titanium suppressed the precipitation of secondary carbides during annealing. The appropriate amount of titanium addition decreased the size and fraction of primary carbides in the as-cast ingot, and improved the mechanical properties of the annealed steel.

  7. Agronomic behavior of pseudo cereals genotypes subjected to drought and salinity conditions; Compotamiento agronomico de genotipos de pseudocereales sometidos a condiciones de sequia y salinidad

    Energy Technology Data Exchange (ETDEWEB)

    Cruz T, E. De la; Garcia A, J.M. [ININ, Carretera Mexico-Toluca, 52750 La Marquesa, Ocoyoacac, (Mexico); Gonzalez R, B.; Laguna C, A. [Centro de Investigacion y Estudios Avanzados en Fitomejoramiento. UAEM, 50200 Toluca (Mexico)]. e-mail:


    With the purpose of evaluating the response to the salinity and drought of 7 genotypes of pseudo cereals that include to the variety of quinua Barandales (M7-0) and to the lines obtained by the radioinduced mutagenesis ININ 110 and ININ 333, two collections of red chia (Opopeo and Huiramangaro) and two collections of 'Huauzontle' of Atlacomulco (H1 and H3), were evaluated under a factorial experimental design two levels of humidity: normal watering and drought and three salinity levels 0, 50 and 100 mMhos. It was found a bigger yield in grams by plant in the drought subjected material (without salinity) and a bigger tolerance to the salinity in the genotypes H3, ININ M7-0, and ININ 110, exhibiting the 'Chia red' bigger susceptibility to the evaluated factors. (Author)

  8. Fuel motion in overpower tests of metallic integral fast reactor fuel

    International Nuclear Information System (INIS)

    Rhodes, E.A.; Bauer, T.H.; Stanford, G.S.; Regis, J.P.; Dickerman, C.E.


    In this paper results from hodoscope data analyses are presented for transient overpower (TOP) tests M5, M6, and M7 at the Transient Reactor Test Facility, with emphasis on transient feedback mechanisms, including prefailure expansion at the tops of the fuel pins, subsequent dispersive axial fuel motion, and losses in relative worth of the fuel pins during the tests. Tests M5 and M6 were the first TOP tests of margin to cladding breach and prefailure elongation of D9-clad ternary (U-Pu-Zr) integral fast reactor-type fuel. Test M7 extended these results to high-burnup fuel and also initiated transient testing of HT-9-clad binary (U-Zr) Fast Flux Test Facility driver fuel. Results show significant prefailure negative reactivity feedback and strongly negative feedback from fuel driven to failure

  9. State Vector: A New Approach to Prediction of the Failure of Brittle Heterogeneous Media and Large Earthquakes (United States)

    Yu, Huai-Zhong; Yin, Xiang-Chu; Zhu, Qing-Yong; Yan, Yu-Ding


    The concept of state vector stems from statistical physics, where it is usually used to describe activity patterns of a physical field in its manner of coarsegrain. In this paper, we propose an approach by which the state vector was applied to describe quantitatively the damage evolution of the brittle heterogeneous systems, and some interesting results are presented, i.e., prior to the macro-fracture of rock specimens and occurrence of a strong earthquake, evolutions of the four relevant scalars time series derived from the state vectors changed anomalously. As retrospective studies, some prominent large earthquakes occurred in the Chinese Mainland (e.g., the M 7.4 Haicheng earthquake on February 4, 1975, and the M 7.8 Tangshan earthquake on July 28, 1976, etc) were investigated. Results show considerable promise that the time-dependent state vectors could serve as a kind of precursor to predict earthquakes.

  10. Characterization of a specific monoclonal antibody against immunoglobulin light kappa/L1 chain in olive flounder (Paralichthys olivaceus)

    DEFF Research Database (Denmark)

    Kim, Young Kyu; Lee, Jung Seok; Jung, Jae Wook


    Immunoglobulins (Ig) are heterodimeric proteins that play critical roles in the adaptive immune system of vertebrates. Because of their plasticity, teleostean Igs are more diverse, and thus do not conform to mammalian classifications. Because of this, mammalian-based Ig cell markers cannot be used...... successfully to study immune responses in fish. There is therefore a need to produce Ig-specific cell markers for fish. Here, we attempted to identify the specific isotype detected by an Ig light chain-specific monoclonal antibody (anti-olive flounder IgL-mAb: M7C3-4) that we had previously produced [11......]. Three newly identified sequences of the Ig light chain from olive flounder were classified according to their isotypes. Subsequent analyses revealed that M7C3-4 was able to specifically detect lymphocytes expressing one of the κ chains (Igκ-a) in olive flounder. Interestingly, Igκ-a+ B cells were more...

  11. In silico prediction of genotoxicity. (United States)

    Wichard, Jörg D


    The in silico prediction of genotoxicity has made considerable progress during the last years. The main driver for the pharmaceutical industry is the ICH M7 guideline about the assessment of DNA reactive impurities. An important component of this guideline is the use of in silico models as an alternative approach to experimental testing. The in silico prediction of genotoxicity provides an established and accepted method that defines the first step in the assessment of DNA reactive impurities. This was made possible by the growing amount of reliable Ames screening data, the attempts to understand the activity pathways and the subsequent development of computer-based prediction systems. This paper gives an overview of how the in silico prediction of genotoxicity is performed under the ICH M7 guideline. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Permanently enhanced dynamic triggering probabilities as evidenced by two M ≥ 7.5 earthquakes (United States)

    Gomberg, Joan S.


    The 2012 M7.7 Haida Gwaii earthquake radiated waves that likely dynamically triggered the 2013M7.5 Craig earthquake, setting two precedents. First, the triggered earthquake is the largest dynamically triggered shear failure event documented to date. Second, the events highlight a connection between geologic structure, sedimentary troughs that act as waveguides, and triggering probability. The Haida Gwaii earthquake excited extraordinarily large waves within and beyond the Queen Charlotte Trough, which propagated well into mainland Alaska and likely triggering the Craig earthquake along the way. Previously, focusing and associated dynamic triggering have been attributed to unpredictable source effects. This case suggests that elevated dynamic triggering probabilities may exist along the many structures where sedimentary troughs overlie major faults, such as subduction zones’ accretionary prisms and transform faults’ axial valleys. Although data are sparse, I find no evidence of accelerating seismic activity in the vicinity of the Craig rupture between it and the Haida Gwaii earthquake.

  13. Precipitation behavior of carbides in high-carbon martensitic stainless steel

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Qin-tian; Li, Jing; Shi, Cheng-bin; Yu, Wen-tao; Shi, Chang-min [University of Science and Technology, Beijing (China). State Key Laboratory of Advanced Metallurgy; Li, Ji-hui [Yang Jiang Shi Ba Zi Group Co., Ltd, Guangdong (China)


    A fundamental study on the precipitation behavior of carbides was carried out. Thermo-calc software, scanning electron microscopy, electron probe microanalysis, transmission electron microscopy, X-ray diffractometry and high-temperature confocal laser scanning microscopy were used to study the precipitation and transformation behaviors of carbides. Carbide precipitation was of a specific order. Primary carbides (M7C3) tended to be generated from liquid steel when the solid fraction reached 84 mol.%. Secondary carbides (M7C3) precipitated from austenite and can hardly transformed into M23C6 carbides with decreasing temperature in air. Primary carbides hardly changed once they were generated, whereas secondary carbides were sensitive to heat treatment and thermal deformation. Carbide precipitation had a certain effect on steel-matrix phase transitions. The segregation ability of carbon in liquid steel was 4.6 times greater that of chromium. A new method for controlling primary carbides is proposed.

  14. Improved inhibitor tolerance in xylose-fermenting yeast Spathaspora passalidarum by mutagenesis and protoplast fusion

    DEFF Research Database (Denmark)

    Hou, Xiaoru; Yao, Shuo


    The xylose-fermenting yeast Spathaspora passalidarum showed excellent fermentation performance utilizing glucose and xylose under anaerobic conditions. But this yeast is highly sensitive to the inhibitors such as furfural present in the pretreated lignocellulosic biomass. In order to improve...... from fusion of the protoplasts of S. passalidarum M7 and a robust yeast, Saccharomyces cerevisiae ATCC 96581, were able to grow in 75% WSLQ and produce around 0.4 g ethanol/g consumed xylose. Among the selected hybrid strains, the hybrid FS22 showed the best fermentation capacity in 75% WSLQ...... the inhibitor tolerance of this yeast, a combination of UV mutagenesis and protoplast fusion was used to construct strains with improved performance. Firstly, UVinduced mutants were screened and selected for improved tolerance towards furfural. The most promised mutant, S. passalidarum M7, produced 50% more...

  15. Transient feedback from fuel motion in metal IFR [Integral Fast Reactor] fuel

    International Nuclear Information System (INIS)

    Rhodes, E.A.; Stanford, G.S.; Regis, J.P.; Bauer, T.H.; Dickerman, C.E.


    Results from hodoscope data analyses are presented for TREAT transient-overpower tests M5 through M7 with emphasis on transient feedback mechanisms, including prefailure expansion at the tops of the fuel pins, subsequent dispersive axial fuel motion, and losses in relative worth of the fuel pins during the tests. Tests M5 and M6 were the first TOP tests of margin to cladding branch and prefailure elongation of D9-clad ternary (U-Pu-Zr) IFR-type fuel. Test M7 extended these results to high-burnup fuel and also initiated transient testing of HT9-clad binary (U-Zr) FFTF-driver fuel. Results show significant prefailure negative reactivity feedback and strongly negative feedback from fuel driven to failure. 4 refs., 6 figs

  16. UBVRH/sub. cap alpha. /-photometry and polarimetry of the Nova Cygni 1975= the V 1500 Cyg

    Energy Technology Data Exchange (ETDEWEB)

    Kiselev, N N; Narizhnaya, N V


    The results of photometric and polarimetric observations of the Nova Cygni 1975 performed at the Gissarskaya Astronomical Observatory from 30.8.75 to 1.2.76 are given. Some outburst development peculiarities are discussed. Some parameters of the Nova Cygni are estimated: absolute magnitude at maximum brightness Msub(max)=-9.sup(m)7; distance r=1.2 kpc; the photospheric radius at maximum brightness of 390 Sun radii.

  17. 77 FR 32021 - Safety Zones: Fireworks Displays in the Captain of the Port Columbia River Zone (United States)


    ...:30 p.m. (2) Tri-City Chamber of Commerce Fireworks Display, Columbia Park, Kennewick, WA: July 4...) Arlington Chamber of Commerce Fireworks Display, Arlington, OR: July 4, 2012 from 8:30 p.m. until 11:30 p.m..., 2012 from 8:30 p.m. until 11:30 p.m. (7) Florence Chamber 4th of July Fireworks Display, Florence, OR...

  18. Hot flushes in prostatic cancer patients during androgen-deprivation therapy with monthly dose of degarelix or leuprolide

    DEFF Research Database (Denmark)

    Iversen, P; Karup, C; van der Meulen, E


    patients received monthly degarelix (s.c., 240/80 mg, n=207, or 240/160 mg, n=202) or leuprolide (i.m., 7.5 mg, n=201) for 12 months. Data on hot flushes was collected as self-reported adverse events and in a subgroup of 254 patients with electronic diaries. The onset of hot flushes was faster on degarelix...

  19. Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes (United States)

    Wen, Bo; Xu, Shuhua; Wang, Yi; Lu, Yan; Wei, Lanhai; Wang, Chuanchao; Li, Shilin; Huang, Xingqiu; Jin, Li; Li, Hui


    Molecular anthropological studies of the populations in and around East Asia have resulted in the discovery that most of the Y-chromosome lineages of East Asians came from Southeast Asia. However, very few Southeast Asian populations had been investigated, and therefore, little was known about the purported migrations from Southeast Asia into East Asia and their roles in shaping the genetic structure of East Asian populations. Here, we present the Y-chromosome data from 1,652 individuals belonging to 47 Mon-Khmer (MK) and Hmong-Mien (HM) speaking populations that are distributed primarily across Southeast Asia and extend into East Asia. Haplogroup O3a3b-M7, which appears mainly in MK and HM, indicates a strong tie between the two groups. The short tandem repeat network of O3a3b-M7 displayed a hierarchical expansion structure (annual ring shape), with MK haplotypes being located at the original point, and the HM and the Tibeto-Burman haplotypes distributed further away from core of the network. Moreover, the East Asian dominant haplogroup O3a3c1-M117 shows a network structure similar to that of O3a3b-M7. These patterns indicate an early unidirectional diffusion from Southeast Asia into East Asia, which might have resulted from the genetic drift of East Asian ancestors carrying these two haplogroups through many small bottle-necks formed by the complicated landscape between Southeast Asia and East Asia. The ages of O3a3b-M7 and O3a3c1-M117 were estimated to be approximately 19 thousand years, followed by the emergence of the ancestors of HM lineages out of MK and the unidirectional northward migrations into East Asia. PMID:21904623

  20. Marine Biotoxins: Laboratory Culture and Molecular Structure (United States)


    ciguateric carnivorous fishes in concentrations ranging from I to 10 ppb. Its molecular structure has been elucidated. It has been isolated from toxic...American Chemical Society, Washington, DC, 1984, pp 217-329. 6. Med. J. Australia 1986, 145 (11/12), 558; 584-5M). 7. "Toxic Plants and Animals A Guide...isolated and grown in the laboratory. Lethality of crude acetone and methanol extracts were assa~ed by ip injection into mice. In vitro cytotoxicity and

  1. Extension of ERIM multispectral data processing capabilities through improved data handling techniques (United States)

    Kriegler, F. J.


    The improvement and extension of the capabilities of the Environmental Research Institute of Michigan processing facility in handling multispectral data are discussed. Improvements consisted of implementing hardware modifications which permitted more rapid access to the recorded data through improved numbering and indexing of such data. In addition, techniques are discussed for handling data from sources other than the ERIM M-5 and M-7 scanner systems.

  2. Understanding Great Earthquakes in Japan's Kanto Region (United States)

    Kobayashi, Reiji; Curewitz, Daniel


    Third International Workshop on the Kanto Asperity Project; Chiba, Japan, 16-19 February 2008; The 1703 (Genroku) and 1923 (Taisho) earthquakes in Japan's Kanto region (M 8.2 and M 7.9, respectively) caused severe damage in the Tokyo metropolitan area. These great earthquakes occurred along the Sagami Trough, where the Philippine Sea slab is subducting beneath Japan. Historical records, paleoseismological research, and geophysical/geodetic monitoring in the region indicate that such great earthquakes will repeat in the future.

  3. Waveform through the subducted plate under the Tokyo region in Japan observed by a ultra-dense seismic network (MeSO-net) and seismic activity around mega-thrust earthquakes area (United States)

    Sakai, S.; Kasahara, K.; Nanjo, K.; Nakagawa, S.; Tsuruoka, H.; Morita, Y.; Kato, A.; Iidaka, T.; Hirata, N.; Tanada, T.; Obara, K.; Sekine, S.; Kurashimo, E.


    In central Japan, the Philippine Sea plate (PSP) subducts beneath the Tokyo Metropolitan area, the Kanto region, where it causes mega-thrust earthquakes, such as the 1703 Genroku earthquake (M8.0) and the 1923 Kanto earthquake (M7.9) which had 105,000 fatalities. A M7 or greater earthquake in this region at present has high potential to produce devastating loss of life and property with even greater global economic repercussions. The Central Disaster Management Council of Japan estimates the next great earthquake will cause 11,000 fatalities and 112 trillion yen (1 trillion US$) economic loss. This great earthquake is evaluated to occur with a probability of 70 % in 30 years by the Earthquake Research Committee of Japan. We had started the Special Project for Earthquake Disaster Mitigation in Tokyo Metropolitan area (2007-2012). Under this project, the construction of the Metropolitan Seismic Observation network (MeSO-net) that consists of about 400 observation sites was started [Kasahara et al., 2008; Nakagawa et al., 2008]. Now, we had 178 observation sites. The correlation of the wave is high because the observation point is deployed at about 2 km intervals, and the identification of the later phase is recognized easily thought artificial noise is very large. We also discuss the relation between a deformation of PSP and intra-plate M7+ earthquakes: the PSP is subducting beneath the Honshu arc and also colliding with the Pacific plate. The subduction and collision both contribute active seismicity in the Kanto region. We are going to present a high resolution tomographic image to show low velocity zone which suggests a possible internal failure of the plate; a source region of the M7+ intra-plate earthquake. Our study will contribute a new assessment of the seismic hazard at the Metropolitan area in Japan. Acknowledgement: This study was supported by the Earthquake Research Institute cooperative research program.

  4. Influence of precipitation behavior on mechanical properties and hydrogen induced cracking during tempering of hot-rolled API steel for tubing

    International Nuclear Information System (INIS)

    Moon, Joonoh; Choi, Jongmin; Han, Seong-Kyung; Huh, Sungyul; Kim, Seong-Ju; Lee, Chang-Hoon; Lee, Tae-Ho


    Precipitation behavior and its effect on hydrogen embrittlement during tempering process of hot-rolled API steel designed with 0.4 wt% Cr and 0.25 wt% Mo were investigated. The base steel was normalized and then tempered at 650 °C for up to 60 min. The precipitation behavior of the examined steel was explored using transmission electron microscopy (TEM) analysis, and it was found that the precipitation sequence during tempering at 650 °C were as follows: MX+M_3C→MX→MX+M_7C_3+M_2_3C_6. The change of particle fraction was measured by electrolytic extraction technique. At the early stage of tempering, the particle fraction greatly decreased due to dissolution of M_3C particle, and increased after 10 min by the precipitation of M_7C_3 and M_2_3C_6 particles. The particle fraction showed a peak at 30 min tempering and decreased again due to the dissolution of M_7C_3 particle. Vickers hardness tests of base steel and tempered samples were carried out, and then the hardness was changed by accompanying with the change of particle fraction. The sensitivity of hydrogen embrittlement was evaluated through hydrogen induced cracking (HIC) tests, and the results clearly proved that HIC resistance of tempered samples was better than that of base steel due to the formation of tempered martensite, and then the HIC resistance changed depending on the precipitation behavior during tempering, i.e., the precipitation of coarse M_2_3C_6 and M_7C_3 particles deteriorated the HIC resistance.

  5. Comparison of an Intermittent Hypoxic Exposure Acclimatization Program to Staging at Moderate Altitude on Endurance Performance at 4300 m (United States)


    Endurance Performance at 4300 m 7 - 6 RTO-MP-HFM-181 breakfast volunteers were provided with two commercially available energy bars and fruit juice composition = 510 kcal, 14 gm fat, 65 gm carbohydrate, 32 gm protein) at 1 to 2 hrs prior to the beginning of each of the cycle endurance test...JE, Robinson SR, Skrinar GS, Lewis SF and Sawka MN. Intermittent altitude exposures improve muscular performance at 4,300 m. J Appl Physiol 95

  6. Nebraska Prostate Cancer Research Program (United States)


    Music m/cce7atz :30 pm...Book Club Tempo of Twilight m/7wqzx pq 7PM Fireside Chat Ayman El- Mohandes Arts Festival /7fgzp5g Arts Festival ...t a n d T a le n t S h o w :30 pm 06 :00 pm VP Music m/cce7atz :30 pm Book

  7. Three-Dimensional Interactions and Vortical Flows with Emphasis on High Speeds (United States)


    pylons, boundary-layer diverters, and unfaired junctions of the wing and tail surfaces with the body are important examples (Meyer 1968; Peake, Rainbird...209, Jan. 1975. Fiechter, M., " Uber Wirbelsysteme an schlanken Rotationskbrpern und ihren Einfluss auf die aerodynamischen Beiwerte," Deutsch...10 0 O . ’ 1N . 2 .4 . .1LL 61 SHUTTLE WINDWARD SURFACE H4EATING FOR (d) CALCULATED WINDWARD VPAN*=S WIND- TUNNEL CONOITIONS M_ - 7.4% 1 EATING FOR

  8. Internal and overall motions of the translation factor eIF4E: Cap binding and insertion in a CHAPS detergent micelle

    International Nuclear Information System (INIS)

    McGuire, Abigail Manson; Matsuo, Hiroshi; Wagner, Gerhard


    The mRNA cap-binding protein eIF4E is the limiting factor in the eIF4F translation initiation complex, which mediates the binding of the 40S ribosome to the mRNA. 15 N relaxation studies have been used to characterize the backbone dynamics of deuterated eIF4E in a CHAPS micelle for the apoprotein, the m 7 GDP-bound form, and the dinucleotide (m 7 GpppA)-bound form, as well as for CHAPS-free eIF4E. Large differences in overall correlation time between the CHAPS-free form (11.8 ns) and samples containing different concentrations of CHAPS (15.9-19.4 ns) indicate that eIF4E is embedded in a large micelle in the presence of CHAPS, with a total molecular weight in the range of 40-60 kDa. CHAPS seems to restrict the mobility of the a2-b3 and a4-b5 loops which are thought to be embedded in the micelle. No significant changes in overall mobility were seen between the m 7 GDP-bound form, the m 7 GpppA-bound form, and the apoprotein. Amide hydrogen exchange data indicate the presence of slowly exchanging amides in two surface-exposed helices (a2 and a4), as well as the a4-b5 loop, indicating protection by the CHAPS micelle. The micelle covers the convex side of the protein away from the cap-binding site

  9. Six new leptospiral serovars isolated from wild animals in Peru.


    Liceras de Hidalgo, J L; Sulzer, K R


    Six new serovars of Leptospira interrogans were isolated from opossums (Didelphis marsupialis and Philander opossum) trapped in the Peruvian jungle. The proposed names, type strain designation, and serogroup of the serovars, respectively, were: huallaga, strain M-7, Djasiman serogroup; luis, strain M-6, Tarassovi serogroup; machiguenga, strain MMD-3, Icterohaemorrhagiae serogroup; rioja, strain MR-12, Bataviae serogroup; rupa rupa, strain M-3, Sejroe serogroup; and tingomaria, strain M-13, Cy...

  10. Behavioral and Socio-Emotional Functioning in Children with Selective Mutism: A Comparison with Anxious and Typically Developing Children across Multiple Informants (United States)

    Carbone, Diana; Schmidt, Louis A.; Cunningham, Charles C.; McHolm, Angela E.; Edison, Shannon; St. Pierre, Jeff; Boyle, Michael H.


    We examined differences among 158 children, 44 with selective mutism (SM; M = 8.2 years, SD = 3.4 years), 65 with mixed anxiety (MA; M = 8.9 years, SD = 3.2 years), and 49 community controls (M = 7.7 years, SD = 2.6 years) on primary caregiver, teacher, and child reports of behavioral and socio-emotional functioning. Children with SM were rated…

  11. Electrical streaming potential precursors to catastrophic earthquakes in China


    Zhao, Y.; Zhao, B.; Qian, F.


    The majority of anomalies in self-potential at 7 stations within 160 km from the epicentre showed a similar pattern of rapid onset and slow decay during and before the M 7.8 Tangshan earthquake of 1976. Considering that some of these anomalies associated with episodical spouting from boreholes or the increase in pore pressure in wells, observed anomalies are streaming potential generated by local events of sudden movements and diffusion process of high-pressure fluid in parallel faults. These...

  12. Validation of MCDS by comparison of predicted with experimental velocity distribution functions in rarefied normal shocks (United States)

    Pham-Van-diep, Gerald C.; Erwin, Daniel A.


    Velocity distribution functions in normal shock waves in argon and helium are calculated using Monte Carlo direct simulation. These are compared with experimental results for argon at M = 7.18 and for helium at M = 1.59 and 20. For both argon and helium, the variable-hard-sphere (VHS) model is used for the elastic scattering cross section, with the velocity dependence derived from a viscosity-temperature power-law relationship in the way normally used by Bird (1976).

  13. Cast-in hardfacing composite

    International Nuclear Information System (INIS)

    Ji, Jia-Lin; Wang, Hua-Ming.


    Tungsten carbide and chromium ferroalloy particles in binderless state were placed on a vacuum sealed mold surface, and a wear resistant surface was formed by pouring high temperature liquid steel into the mold cavity. Higher surface hardness HRC 65-69 and increased toughness were obtained by this composite material. It is shown that a strengthened martensitic matrix alloyed by tungsten and chromium supports tungsten carbide particles as well as reformed carbides (M6C, M7C3). 3 refs

  14. AcEST: DK961935 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 2V5|A5H2V5_9BILA Ahn-4 OS=Steinernema carpocapsae PE=4 SV=1 37 0.65 tr|Q5M7R7|Q5M...DHHHDHDHHHH 373 >tr|A5H2V5|A5H2V5_9BILA Ahn-4 OS=Steinernema carpocapsae PE=4 SV=1 Length = 61 Score = 36.6

  15. Untitled

    Indian Academy of Sciences (India)

    3, Garrido, J. . . C.R. Acad. Sci., 1950, 230, 1878. 4. Guan Ya-Siyan, Simonov, Docklady Acad. Sci., USSR, 1963, 149, 146. V.I., and Belov, N. V.. 5. Hoppe, W. . . Acta Cryst., 1963, 16, 1056,. 6. Main, D. and Woolfson, Ibid., 1963, 16, 1046. : M. M.. 7. McLachlan, D. and Proc. Nat. Acad. Sei, USA, 1957, 37, 846,. Harker, D. 8.

  16. Dicty_cDB: Contig-U06692-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ocentrotus purpuratus clone R3-14E12, WOR... 50 0.057 1 ( T09672 ) 0251m7 gmbPfHB3.1, G. Roman Reddy Plasmod...ium falcip... 50 0.057 1 ( AA550389 ) 1537m3 gmbPfHB3.1, G. Roman Reddy Plasmodium falc... 50 0.057 1 ( EC82

  17. Dicty_cDB: VSF305 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ow=L, DNA sequence. 44 1e-06 3 T09672 |T09672.1 0251m7 gmbPfHB3.1, G. Roman Reddy Plasmodium falciparum geno...mic clone 0251m, DNA sequence. 50 1e-06 2 AA550389 |AA550389.1 1537m3 gmbPfHB3.1, G. Roman Reddy

  18. Dicty_cDB: VSF343 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ol=24 Row=L, DNA sequence. 44 1e-06 3 T09672 |T09672.1 0251m7 gmbPfHB3.1, G. Roman Reddy Plasmodium genomic clone 0251m, DNA sequence. 50 1e-06 2 AA550389 |AA550389.1 1537m3 gmbPfHB3.1, G. Roman Reddy

  19. Optimisation of decontamination method and influence of culture media on the recovery of Mycobacterium avium subspecies paratuberculosis from spiked water sediments. (United States)

    Aboagye, G; Rowe, M T


    The recovery of Mycobacterium avium subspecies paratuberculosis (Map) from the environment can be a laborious process - owing to Map being fastidious, its low number, and also high numbers of other microbial populations in such settings. Protocols i.e. filtration, decontamination and modified elution were devised to recover Map from spiked water sediments. Three culture media: Herrold's Egg Yolk Media (HEYM), Middlebrook 7H10 (M-7H10) and Bactec 12B were then employed to grow the organism following its elution. In the sterile sediment samples the recovery of Map was significant between the time of exposure for each of HEYM and M-7H10, and insignificant between both media (P < 0.05). However, in the non-sterile sediment samples, the HEYM grew other background microflora including moulds at all the times of exposure whilst 4 h followed by M-7H10 culture yielded Map colonies without any background microflora. Using sterile samples only for the Bactec 12B, the recovery of Map decreased as time of exposure increased. Based on these findings, M-7H10 should be considered for the recovery of Map from the natural environment including water sediments where the recovery of diverse microbial species remains a challenge. Map is a robust pathogen that abides in the environment. In water treatment operations, Map associates with floccules and other particulate matter including sediments. It is also a fastidious organism, and its detection and recovery from the water environment is a laborious process and can be misleading within the abundance of other mycobacterial species owing to their close resemblance in phylogenetic traits. In the absence of a reliable recovery method, Map continues to pose public health risks through biofilm in household water tanks, hence the need for the development of a reliable recovery protocol to monitor the presence of Map in water systems in order to curtail its public health risks. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. Molecular Evolution of the Glycosyltransferase 6 Gene Family in Primates

    Directory of Open Access Journals (Sweden)

    Eliane Evanovich


    Full Text Available Glycosyltransferase 6 gene family includes ABO, Ggta1, iGb3S, and GBGT1 genes and by three putative genes restricted to mammals, GT6m6, GTm6, and GT6m7, only the latter is found in primates. GT6 genes may encode functional and nonfunctional proteins. Ggta1 and GBGT1 genes, for instance, are pseudogenes in catarrhine primates, while iGb3S gene is only inactive in human, bonobo, and chimpanzee. Even inactivated, these genes tend to be conversed in primates. As some of the GT6 genes are related to the susceptibility or resistance to parasites, we investigated (i the selective pressure on the GT6 paralogs genes in primates; (ii the basis of the conservation of iGb3S in human, chimpanzee, and bonobo; and (iii the functional potential of the GBGT1 and GT6m7 in catarrhines. We observed that the purifying selection is prevalent and these genes have a low diversity, though ABO and Ggta1 genes have some sites under positive selection. GT6m7, a putative gene associated with aggressive periodontitis, may have regulatory function, but experimental studies are needed to assess its function. The evolutionary conservation of iGb3S in humans, chimpanzee, and bonobo seems to be the result of proximity to genes with important biological functions.

  1. Lariat capping as a tool to manipulate the 5' end of individual yeast mRNA species in vivo

    DEFF Research Database (Denmark)

    Krogh, Nicolai; Pietschmann, Max; Schmid, Manfred


    The 5' cap structure of eukaryotic mRNA is critical for its processing, transport, translation, and stability. The many functions of the cap and the fact that most, if not all, mRNA carries the same type of cap makes it difficult to analyze cap function in vivo at individual steps of gene...... in the budding yeast Saccharomyces cerevisiae presumably without cofactors and that lariat capping occurs cotranscriptionally. The lariat-capped reporter mRNA is efficiently exported to the cytoplasm where it is found to be oligoadenylated and evenly distributed. Both the oligoadenylated form and a lariat......-capped mRNA with a templated poly(A) tail translates poorly, underlining the critical importance of the m(7)G cap in translation. Finally, the lariat-capped RNA exhibits a threefold longer half-life compared to its m(7)G-capped counterpart, consistent with a key role for the m(7)G cap in mRNA turnover. Our...

  2. Identification of rotundic acid metabolites after oral administration to rats and comparison with the biotransformation by Syncephalastrum racemosum AS 3.264. (United States)

    Li, Hui; Yang, Bao; Cao, Di; Zhou, Lian; Wang, Qing; Rong, Li; Zhou, Xinghong; Jin, Jing; Zhao, Zhongxiang


    The objective of this study was to identify the metabolites of rotundic acid after oral administration to rats and compare the similarities with its biotransformation by Syncephalastrum racemosum AS 3.264 using ultra-high performance liquid chromatography coupled with quadrupole time of flight mass spectrometry. A total of fourteen metabolites were determined based on the mass spectrometry and chromatographic behaviors, among which eleven (M1-M3, M7-M14) and six (M2, M4-M8) metabolites were identified in rats and S. racemosum, respectively. Three identical metabolites (M2, M7 and M8) were found in rats and S. racemosum, indicating that there were metabolic similarities. Moreover, to confirm the results of mass spectrometry, three (M2, M4 and M7) metabolites were obtained by the means of amplifying incubation and their structures were determined by various spectroscopic analyses, and M4 was proved to be a previously undescribed compound. This results showed that in vitro assisted preparation by microbial transformation is a feasible and effective method of obtaining metabolites which are in low amounts and difficult to be prepared in vivo. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Iron availability in the presence of β-carotene in different mixtures

    Directory of Open Access Journals (Sweden)

    Romilda Maria de Arruda Germano


    Full Text Available Iron availability in the diet is very important because iron deficiency affects a large population in the world. The matrix where iron is present has an influence in its availability. The presence of β-carotene is a factor that alters the availability of iron. This research aims to estimate the iron availability in the presence of β-carotene in food mixtures: M1 = egg and pumpkin; M2 = spinach and pumpkin; M3 = spinach and cabbage; M4 = egg and cabbage; M5 = spinach and carrot; M6 = egg and carrot; M7 = bean and carrot; M8 = bean and pumpkin and M9 = bean and cabbage. After cooking, the following figures were determined: proximate composition, oxalic acid, phytic acid, tannin, iron, iron availability in vitro and β-carotene. The data were analyzed by Tukey test (5%. There were no significant statistical differences for oxalic acid. Tannin presented greater results in mixtures with spinach (M2 and M5; phytic acid was greater in bean samples (M7, M8 and M9 and with spinach (M2. Mixtures M5 e M7, with carrot, presented more β-carotene than the others. The best result for iron availability appeared in mixture (M6. A positive correlation was verified between protein and iron dialysis, and between lipids and iron dialysis. Dietetic fiber was an inhibitor to iron availability. Mixtures with egg showed greater iron availability

  4. In planta functions of cytochrome P450 monooxygenase genes in the phytocassane biosynthetic gene cluster on rice chromosome 2. (United States)

    Ye, Zhongfeng; Yamazaki, Kohei; Minoda, Hiromi; Miyamoto, Koji; Miyazaki, Sho; Kawaide, Hiroshi; Yajima, Arata; Nojiri, Hideaki; Yamane, Hisakazu; Okada, Kazunori


    In response to environmental stressors such as blast fungal infections, rice produces phytoalexins, an antimicrobial diterpenoid compound. Together with momilactones, phytocassanes are among the major diterpenoid phytoalexins. The biosynthetic genes of diterpenoid phytoalexin are organized on the chromosome in functional gene clusters, comprising diterpene cyclase, dehydrogenase, and cytochrome P450 monooxygenase genes. Their functions have been studied extensively using in vitro enzyme assay systems. Specifically, P450 genes (CYP71Z6, Z7; CYP76M5, M6, M7, M8) on rice chromosome 2 have multifunctional activities associated with ent-copalyl diphosphate-related diterpene hydrocarbons, but the in planta contribution of these genes to diterpenoid phytoalexin production remains unknown. Here, we characterized cyp71z7 T-DNA mutant and CYP76M7/M8 RNAi lines to find that potential phytoalexin intermediates accumulated in these P450-suppressed rice plants. The results suggested that in planta, CYP71Z7 is responsible for C2-hydroxylation of phytocassanes and that CYP76M7/M8 is involved in C11α-hydroxylation of 3-hydroxy-cassadiene. Based on these results, we proposed potential routes of phytocassane biosynthesis in planta.

  5. Seismomagnetic models for earthquakes in the eastern part of Izu Peninsula, Central Japan

    Directory of Open Access Journals (Sweden)

    Y. Ishikawa


    Full Text Available Seismomagnetic changes accompanied by four damaging earthquakes are explained by the piezomagnetic effect observed in the eastern part of Izu Peninsula, Central Japan. Most of the data were obtained by repeat surveys. Although these data suffered electric railway noise, significant magnetic changes were detected at points close to earthquake faults. Coseismic changes can be well interpreted by piezomagnetic models in the case of the 1978 Near Izu-Oshima (M 7.0 and the 1980 East Off Izu Peninsula (M 6.7 earthquakes. A large total intensity change up to 5 nT was observed at a survey point almost above the epicenter of the 1976 Kawazu (M 5.4 earthquake. This change is not explained by a single fault model; a 2-segment fault is suggested. Remarkable precursory and coseismic changes in the total force intensity were observed at KWZ station along with the 1978 Higashi-Izu (M 4.9 earthquake. KWZ station is located very close to a buried subsidiary fault of the M 7.0 Near Izu-Oshima earthquake, which moved aseismically at the time of the M 7.0 quake. The precursory magnetic change to the M 4.9 quake is ascribed to aseismic faulting of this buried fault, while the coseismic rebound to enlargement of the slipping surface at the time of M 4.9 quake. This implies that we observed the formation process of the earthquake nucleation zone via the magnetic field.

  6. Paleoearthquakes at Frazier Mountain, California delimit extent and frequency of past San Andreas Fault ruptures along 1857 trace (United States)

    Scharer, Katherine M.; Weldon, Ray; Streig, Ashley; Fumal, Thomas


    Large earthquakes are infrequent along a single fault, and therefore historic, well-characterized earthquakes exert a strong influence on fault behavior models. This is true of the 1857 Fort Tejon earthquake (estimated M7.7–7.9) on the southern San Andreas Fault (SSAF), but an outstanding question is whether the 330 km long rupture was typical. New paleoseismic data for six to seven ground-rupturing earthquakes on the Big Bend of the SSAF restrict the pattern of possible ruptures on the 1857 stretch of the fault. In conjunction with existing sites, we show that over the last ~650 years, at least 75% of the surface ruptures are shorter than the 1857 earthquake, with estimated rupture lengths of 100 to <300 km. These results suggest that the 1857 rupture was unusual, perhaps leading to the long open interval, and that a return to pre-1857 behavior would increase the rate of M7.3–M7.7 earthquakes.

  7. Seismic triggering of landslides, Part A: Field evidence from the Northern Tien Shan (United States)

    Havenith, H.-B.; Strom, A.; Jongmans, D.; Abdrakhmatov, A.; Delvaux, D.; Tréfois, P.

    Landslides triggered by strong earthquakes often caused most of the global damage and most of all casualties related to the events, such as shown by the M = 7.7 Peru earthquake in 1970, by the M = 7.6 El Salvador earthquake in 2001 or by the M = 7.4 Khait (Tajikistan) earthquake in 1949. The obvious impact of a landslide on the population is directly related to its movement. Yet, prediction of future failure potential and hence future risk to population is necessary in order to avoid further catastrophes and involves the analyses of the origin of seismic instability. The seismic landslide potential is mainly determined by the interaction between the regional seismic hazard and local geological conditions. At a local scale, seismic factors interfering with geological conditions can produce site-specific ground motions. The influence of such Site Effects on instability is the principal topic of this paper, which is divided into two parts, A and B. The present Part A is concerned with the correlation of field data with observed instability phenomena. Field data were obtained on mainly three landslide sites in the Northern Tien Shan Mountains in Kyrgyzstan, Central Asia. Geophysical prospecting, earthquake recordings, geological observation, trenching and geotechnical tests were the main investigation tools. The collected information gives an insight in the geological background of the slope failure and allows us to roughly infer failure mechanisms from field evidence. A detailed analysis of the susceptibility of a mechanism to specific geological conditions will be shown in Part B.


    Directory of Open Access Journals (Sweden)

    José L. García Hernández


    Full Text Available The Comarca Lagunera region is the most important area of maize forage in México. In this region; which is shared by the Mexican States of Coahuila and Durango, are used a great amount of hybrids and varieties of maize imported from other countries. Generally, these genotypes are not completely adapted to the soil and/or climatic conditions of the region. These antecedents lead scientists to pursuit for genotypes with the best adaptation to such conditions. The present investigation was carried out with the aim to find the best hybrids from the crosses of ten self-pollinating landraces following a diallel mating design. The landraces were obtained from different institutions: a the International Maize and Wheat Improvement Center (CIMMYT, b the “Antonio Narro” Agrarian Autonomist University (UAAAN, and c the National Institute of Agriculture, Forestry and Livestock Research (INIFAP. The following variables were evaluated from the hybrids: whole plant fresh matter yield (FMY, whole plant dry matter (DMY, fresh fruit yield (FFY fresh stem yield (FSY, and fresh foliar yield (FLY. All variables reported as t ha-1. The Griffing statistical analysis was used to determine the general combining ability (GCA, and the specific combining ability (SCA. The highest values of GCA were obtained for the landraces M7, M8, and M9. The hybrids with highest SCA were: M5xM7, M2xM7, M6x10, M4xM8, M5xM8, M8xM10, M2xM5, M1xM10 and M6xM9. Two of these hybrids (M5xM7 and M2xM7 also showed the highest values for FMY and DMY. In conclusion, there is enough variability on FMY and DMY to believe on the possibility to find the most appropriate hybrid for the targeted region, and also to extend the breeding program to other arid lands in México

  9. A new tomographic image on the Philippine Sea Slab beneath Tokyo - Implication to seismic hazard in the Tokyo metropolitan region - (United States)

    Hirata, N.; Sakai, S.; Nakagawa, S.; Ishikawa, M.; Sato, H.; Kasahara, K.; Kimura, H.; Honda, R.


    In central Japan, the Philippine Sea plate (PSP) subducts beneath the Tokyo metropolitan region. Devastating M8-class earthquakes occurred on the upper surface of the Philippine Sea plate (SPS), examples of which are the Genroku earthquake of 1703 (magnitude M=8.0) and the Kanto earthquake of 1923 (M=7.9), which had 105,000 fatalities. A M7 or greater (M7+) earthquake in this region at present has high potential to produce devastating loss of life and property with even greater global economic repercussions although it is smaller than the megathrust type M8-class earthquakes. This great earthquake is evaluated to occur with a probability of 70 % in 30 years by the Earthquake Research Committee of Japan. The M7+ earthquakes may occur either on the upper surface or intra slab of PSP. The Central Disaster Management Council of Japan estimates the next great M7+ earthquake will cause 11,000 fatalities and 112 trillion yen (1 trillion US$) economic loss at worst case if it occur beneath northern Tokyo bay with M7.3. However, the estimate is based on a source fault model by conventional studies about the PSP geometry. To evaluate seismic hazard due to the great quake we need to clarify the geometry of PSP and also the Pacific palate (PAP) that subducs beneath PSP. We identify those plates with use of seismic tomography and available deep seismic reflection profiling and borehole data in southern Kanto area. We deployed about 300 seismic stations in the greater Tokyo urban region under the Special Project for Earthquake Disaster Mitigation in Tokyo Metropolitan Area. We obtain clear P- and S- wave velocity (Vp and Vs) tomograms which show a clear image of PSP and PAP. A depth to the top of PSP, 20 to 30 kilometer beneath northern part of Tokyo bay, is about 10 km shallower than previous estimates based on the distribution of seismicity (Ishida, 1992). This shallower plate geometry changes estimations of strong ground motion for seismic hazards analysis within the Tokyo

  10. Impact of the 2001 Tohoku-oki earthquake to Tokyo Metropolitan area observed by the Metropolitan Seismic Observation network (MeSO-net) (United States)

    Hirata, N.; Hayashi, H.; Nakagawa, S.; Sakai, S.; Honda, R.; Kasahara, K.; Obara, K.; Aketagawa, T.; Kimura, H.; Sato, H.; Okaya, D. A.


    The March 11, 2011 Tohoku-oki earthquake brought a great impact to the Tokyo metropolitan area in both seismological aspect and seismic risk management although Tokyo is located 340 km from the epicenter. The event generated very strong ground motion even in the metropolitan area and resulted severe requifaction in many places of Kanto district. National and local governments have started to discuss counter measurement for possible seismic risks in the area taking account for what they learned from the Tohoku-oki event which is much larger than ever experienced in Japan Risk mitigation strategy for the next greater earthquake caused by the Philippine Sea plate (PSP) subducting beneath the Tokyo metropolitan area is of major concern because it caused past mega-thrust earthquakes, such as the 1703 Genroku earthquake (M8.0) and the 1923 Kanto earthquake (M7.9). An M7 or greater (M7+) earthquake in this area at present has high potential to produce devastating loss of life and property with even greater global economic repercussions. The Central Disaster Management Council of Japan estimates that an M7+ earthquake will cause 11,000 fatalities and 112 trillion yen (about 1 trillion US$) economic loss. In order to mitigate disaster for greater Tokyo, the Special Project for Earthquake Disaster Mitigation in the Tokyo Metropolitan Area was launched in collaboration with scientists, engineers, and social-scientists in nationwide institutions. We will discuss the main results that are obtained in the respective fields which have been integrated to improve information on the strategy assessment for seismic risk mitigation in the Tokyo metropolitan area; the project has been much improved after the Tohoku event. In order to image seismic structure beneath the Metropolitan Tokyo area we have developed Metropolitan Seismic Observation network (MeSO-net; Hirata et al., 2009). We have installed 296 seismic stations every few km (Kasahara et al., 2011). We conducted seismic

  11. In vitro metabolism of the anti-androgenic fungicide vinclozolin by rat liver microsomes. (United States)

    Sierra-Santoyo, Adolfo; Angeles-Soto, Esperanza; de Lourdes López-González, Ma; Harrison, Randy A; Hughes, Michael F


    Vinclozolin (V) is a fungicide used in agricultural settings. V administered to rats is hydrolyzed to 2-[[(3,5-dichlorophenyl)-carbamoyl]oxy]-2-methyl-3-butenoic acid (M1) and 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide (M2). V, M1 and M2 have antiandrogenic properties by interacting with the androgen receptor. Data on V, M1 and M2 biotransformation are limited. Our objective was to characterize V metabolism by rat liver microsomes. V was incubated with non-treated adult male Long-Evans rat liver microsomes and NADPH. Several metabolites were detected following the extraction of incubate with acetonitrile and analysis by HPLC/DAD/MSD. One metabolite was identified as [3-(3,5-dichlorophenyl)-5-methyl-5-(1,2-dihydroxyethyl)-1,3-oxazolidine-2,4-dione] (M4), which was gradually converted to 3',5'-dichloro-2,3,4-trihydroxy-2-methylbutylanilide (M5). Both co-eluted in the same HPLC peak. Another metabolite ([M7]) was detected by UV but was unstable for mass spectral analysis. The K(M app) for co-eluted M4/M5 and [M7] was 53.7 and 135.4 μM, the V(max app) was 0.812 and 0.669 nmoles/min/mg protein, and CL(int) was 15.1 and 4.9 ml/min/g protein, respectively. Pilocarpine, orphenadrine and proadifen and anti-rat cytochrome P450 (CYP)2A, 2B and 3A antibodies inhibited M4/M5 and [M7] formation. These results indicate that V is efficiently metabolized by CYP. Determination of the metabolites of V will provide further insight into the relationship between toxicity and tissue dose of V and its metabolites.

  12. Characterization of cap binding proteins associated with the nucleus

    International Nuclear Information System (INIS)

    Patzelt, E.


    Eucaryotic mRNAs a carry 7-methylguanosine triphosphate residue (called cap structure) at their 5' terminus. The cap plays an important role in RNA recognition. Cap binding proteins (CBP) of HeLa cells were identified by photoaffinity labelling using the cap analogue γ-( 32 P)-(4-(benzoyl-phenyl)methylamido)-7-methylguanosine-5'-triphosphate (BP-m 7 GTP). Photoreaction of this cap analogue with HeLa cell initiation factors resulted in specific labelling of two polypeptides of Msub(r) 37000 and 26000. The latter was also labelled in crude initiation factors prepared from reticulocytes and is identical to the cap binding protein CBP I previously identified. These cap binding proteins were also affinity labelled in poliovirus infected cell extracts. Photoaffinity reaction with BP-m 7 GTP of whole HeLa cell homogenate showed three additional polypeptides with Msub(r) 120000, 89000 and 80000. These cap binding proteins were found to be associated with the nucleus and are therefore referred to as nuclear cap binding proteins, i.e. NCBP 1, NCBP 2 and NCBP 3. They were also present in splicing extracts. Photoaffinity labelling in these nuclear extracts was differentially inhibited by various cap analogues and capped mRNAs. Affinity chromatography on immobilized globin mRNA led to a partial separation of the three nuclear cap binding proteins. Chromatography on m 7 GTP-Sepharose resulted in a specific binding of NCBP 3. The different behaviour of the cap binding proteins suggests that they are functionally distinct and that they might be involved in different processes requiring cap recognition. (Author)

  13. International Aftershock Forecasting: Lessons from the Gorkha Earthquake (United States)

    Michael, A. J.; Blanpied, M. L.; Brady, S. R.; van der Elst, N.; Hardebeck, J.; Mayberry, G. C.; Page, M. T.; Smoczyk, G. M.; Wein, A. M.


    Following the M7.8 Gorhka, Nepal, earthquake of April 25, 2015 the USGS issued a series of aftershock forecasts. The initial impetus for these forecasts was a request from the USAID Office of US Foreign Disaster Assistance to support their Disaster Assistance Response Team (DART) which coordinated US Government disaster response, including search and rescue, with the Government of Nepal. Because of the possible utility of the forecasts to people in the region and other response teams, the USGS released these forecasts publicly through the USGS Earthquake Program web site. The initial forecast used the Reasenberg and Jones (Science, 1989) model with generic parameters developed for active deep continental regions based on the Garcia et al. (BSSA, 2012) tectonic regionalization. These were then updated to reflect a lower productivity and higher decay rate based on the observed aftershocks, although relying on teleseismic observations, with a high magnitude-of-completeness, limited the amount of data. After the 12 May M7.3 aftershock, the forecasts used an Epidemic Type Aftershock Sequence model to better characterize the multiple sources of earthquake clustering. This model provided better estimates of aftershock uncertainty. These forecast messages were crafted based on lessons learned from the Christchurch earthquake along with input from the U.S. Embassy staff in Kathmandu. Challenges included how to balance simple messaging with forecasts over a variety of time periods (week, month, and year), whether to characterize probabilities with words such as those suggested by the IPCC (IPCC, 2010), how to word the messages in a way that would translate accurately into Nepali and not alarm the public, and how to present the probabilities of unlikely but possible large and potentially damaging aftershocks, such as the M7.3 event, which had an estimated probability of only 1-in-200 for the week in which it occurred.

  14. The ordered network structure and prediction summary for M ≥ 7 earthquakes in Xinjiang region of China

    International Nuclear Information System (INIS)

    Men, Ke-Pei; Zhao, Kai


    M ≥ 7 earthquakes have showed an obvious commensurability and orderliness in Xinjiang of China and its adjacent region since 1800. The main orderly values are 30 a x k (k = 1, 2, 3), 11 ∝ 12 a, 41 ∝ 43 a, 18 ∝ 19 a, and 5 ∝ 6 a. In the guidance of the information forecasting theory of Wen-Bo Weng, based on previous research results, combining ordered network structure analysis with complex network technology, we focus on the prediction summary of M ≥ 7 earthquakes by using the ordered network structure, and add new information to further optimize network, hence construct the 2D- and 3D-ordered network structure of M ≥ 7 earthquakes. In this paper, the network structure revealed fully the regularity of seismic activity of M ≥ 7 earthquakes in the study region during the past 210 years. Based on this, the Karakorum M7.1 earthquake in 1996, the M7.9 earthquake on the frontier of Russia, Mongol, and China in 2003, and two Yutian M7.3 earthquakes in 2008 and 2014 were predicted successfully. At the same time, a new prediction opinion is presented that the future two M ≥ 7 earthquakes will probably occur around 2019-2020 and 2025-2026 in this region. The results show that large earthquake occurred in defined region can be predicted. The method of ordered network structure analysis produces satisfactory results for the mid-and-long term prediction of M ≥ 7 earthquakes.

  15. Productivity and Nutrient Quality of Some Sorghum Mutant Lines at Different Cutting Ages

    Directory of Open Access Journals (Sweden)

    R. E. Puteri


    Full Text Available The objective of the study was to explore the appropriate cutting age to produce optimal biomass and good nutrient quality from sorghum mutant lines BMR i.e., PATIR 3.5 M7, PATIR 3.6 M7, and PATIR 3.7 M7, also SAMURAI I (M17. A completely randomized in Split Plot design with 2 factors and 3 replicates was used. The first factor was the type of sorghum (SAMURAI I M17, PATIR 3.5, PATIR 3.6, PATIR 3.7 as the main plot and the second factor was the cutting age (85, 95, 105 as a subplot. Parameters observed were the production of stems, leaves, grains, total biomass production, ash, crude fat, crude fiber, crude protein, NFE, TDN, percentage of DMD, OMD and N-NH3. Data were analyzed by using ANOVA followed by DMRT (Duncan Multiple Range Test. The results showed that there were highly significant interactions (P<0.01 between cutting age and type of sorghum in production of stems, leaves, grains, total biomass production, value of TDN, DMD, OMD, and N-NH3. Increasing cutting age significantly increased the percentage of ash content, crude protein and crude fat. The sorghum type significantly affected crude fat content nonBMR sorghum variety of SAMURAI I (M17 and achieved optimal biomass production and nutrient content at cutting age of 85 d similar to BMR sorghum mutant lines PATIR 3.6 and PATIR 3.5, whereas BMR sorghum mutant lines of PATIR 3.7 achieved optimum production at the age of 95 d of cutting. All types of sorghum varieties was not recommended to be harvested at 105 d. Biomass production increased with the increasing of cutting age, but the nutrient content decreased.

  16. Constraints on the Equation-of-State of neutron stars from nearby neutron star observations

    International Nuclear Information System (INIS)

    Neuhäuser, R; Hambaryan, V V; Hohle, M M; Eisenbeiss, T


    We try to constrain the Equation-of-State (EoS) of supra-nuclear-density matter in neutron stars (NSs) by observations of nearby NSs. There are seven thermally emitting NSs known from X-ray and optical observations, the so-called Magnificent Seven (M7), which are young (up to few Myrs), nearby (within a few hundred pc), and radio-quiet with blackbody-like X-ray spectra, so that we can observe their surfaces. As bright X-ray sources, we can determine their rotational (pulse) period and their period derivative from X-ray timing. From XMM and/or Chandra X-ray spectra, we can determine their temperature. With precise astrometric observations using the Hubble Space Telescope, we can determine their parallax (i.e. distance) and optical flux. From flux, distance, and temperature, one can derive the emitting area - with assumptions about the atmosphere and/or temperature distribution on the surface. This was recently done by us for the two brightest M7 NSs RXJ1856 and RXJ0720. Then, from identifying absorption lines in X-ray spectra, one can also try to determine gravitational redshift. Also, from rotational phase-resolved spectroscopy, we have for the first time determined the compactness (mass/radius) of the M7 NS RBS1223. If also applied to RXJ1856, radius (from luminosity and temperature) and compactness (from X-ray data) will yield the mass and radius - for the first time for an isolated single neutron star. We will present our observations and recent results.

  17. A Geodynamic Study of Active Crustal Deformation and Earthquakes in North China (United States)

    Yang, Y.; Liu, M.


    North China is part of the Archaean Sino-Korean craton, yet today it is a region of intense crustal deformation and earthquakes, including 21 M >=7.0 events since 512 AD. More than half of the large events occurred within the Fen-Wei rift system surrounding the stable Ordos plateau; the largest events (M >=7.3) show a sequential southward migration along the rift. However, since 1695 the Fen-Wei rift has became seismically dormant, while seismicity seems having shifted eastward to the North China plain, marked by the 1996 Tangshan earthquake (M=7.8). We have developed a 3D viscoelastic geodynamic model to study the cause of seismicity and its spatial-temporal pattern in North China. Constrained by crustal kinematics from GPS and neotectonic data, the model shows high deviatoric stress in the North China crust, resulting mainly from compression of the expanding Tibetan Plateau and resistance from the stable Siberian block. Within North China seismicity is largely controlled by lateral heterogeneity of lithospheric structures, which explains the concentration of seismicity in the Fen-Wei rift. Our results show that stress triggering may have contributed to the sequential migration of large events along the rift, and the release and migration of stress and strain energy from these large events may partially explain the intense seismicity in the North China plain in the past 300 years. Comparing the predicted long-term spatial pattern of strain energy with seismic energy release provides some insights of potential earthquake risks in North China.

  18. Dynamic conformations of nucleophosmin (NPM1 at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B.

    Directory of Open Access Journals (Sweden)

    Wei D Duan-Porter

    Full Text Available Nucleophosmin (NPM1 is an abundant, nucleolar tumor antigen with important roles in cell proliferation and putative contributions to oncogenesis. Wild-type NPM1 forms pentameric oligomers through interactions at the amino-terminal core domain. A truncated form of NPM1 found in some hepatocellular carcinoma tissue formed an unusually stable oligomer and showed increased susceptibility to cleavage by granzyme B. Initiation of translation at the seventh methionine generated a protein (M7-NPM that shared all these properties. We used deuterium exchange mass spectrometry (DXMS to perform a detailed structural analysis of wild-type NPM1 and M7-NPM, and found dynamic conformational shifts or local "unfolding" at a specific monomer-monomer interface which included the β-hairpin "latch." We tested the importance of interactions at the β-hairpin "latch" by replacing a conserved tyrosine in the middle of the β-hairpin loop with glutamic acid, generating Y67E-NPM. Y67E-NPM did not form stable oligomers and further, prevented wild-type NPM1 oligomerization in a dominant-negative fashion, supporting the critical role of the β-hairpin "latch" in monomer-monomer interactions. Also, we show preferential cleavage by granzyme B at one of two available aspartates (either D161 or D122 in M7-NPM and Y67E-NPM, whereas wild-type NPM1 was cleaved at both sites. Thus, we observed a correlation between the propensity to form oligomers and granzyme B cleavage site selection in nucleophosmin proteins, suggesting that a small change at an important monomer-monomer interface can affect conformational shifts and impact protein-protein interactions.

  19. Culture phenotypes and molecular characterization of Mycobacterium avium subsp. paratuberculosis isolates from small ruminants. (United States)

    Dimareli-Malli, Z; Mazaraki, K; Stevenson, K; Tsakos, P; Zdragas, A; Giantzi, V; Petridou, E; Heron, I; Vafeas, G


    In this study the suitability of different solid media was investigated for the isolation of Mycobacterium avium subsp. paratuberculosis (Map) in order to identify the optimum single or combination of media to permit the isolation of all strain types from small ruminants. A subset of these Map strains was then further characterized by molecular typing methods to assess the genetic diversity of Map strains in the study area (Northern Greece). Map strains were isolated from tissues and faeces of infected goats (n=52) and sheep (n=8) and were analysed for polymorphisms in IS1311 to classify the strain type as Type C or S. The study found that M7H11 supplemented with mycobactin j, OADC and new born calf serum (M7H11+Mj) is the best single choice of medium for the primary isolation of Map of both Type C and S from small ruminants. The combination of M7H11+Mj and Herrolds egg yolk medium supplemented with mycobactin j and sodium pyruvate allowed the detection of all Map isolates in this study. Nineteen Map isolates were characterised by pulsed-field gel electrophoresis and the isolates demonstrated significant genetic diversity. Twelve different SnaBI and 16 distinct SpeI profiles were detected of which 25 have not been described previously and are new profiles. The combination of both enzyme profiles gave 13 different multiplex profiles. Ten different multiplex profiles were detected in goats and three in sheep. One ovine isolate gave the same multiplex profile as a caprine isolate and two different profiles were found within a single goat herd. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. [Study on the phase II metabolites of phenoprolamine hydrochloride in rat bile by LC/DAD/MSD]. (United States)

    Ding, L; Zhang, Z X; Ni, P Z; Wang, G J; An, D K


    To study the phase II metabolites of phenoprolamine hydrochloride (DDPH) in rat bile. DDPH was administered by i.p. to bile duct-cannulated rats. Bile samples were collected before drug administration and up to 12 h after drug administration. After being purified and enriched with C-18 SPE columns the rat bile samples were analyzed by LC/DAD/MSD to identify the peaks of phase II metabolites. The fractions of phase II metabolites were prepared by HPLC and treated with beta-glucuronidase, and then were purified and enriched with C-18 SPE columns and analyzed by LC/DAD/MSD. The corresponding reference standards of DDPH phase I metabolites were analyzed by LC/DAD/MSD under identical conditions. The peaks M7, M8 and M9 in the chromatograms of rat bile samples were the phase II metabolites of DDPH and the enzymatic hydrolysates of M7, M8 and M9 were 1-(2, 6-dimethyl-4-hydroxyphenoxy)-2-(3, 4-methoxyphenylethylamino)-propane (M3), 1-(2, 6-dimethyl-3-hydroxyphenoxy)-2-(3, 4-methoxyphenylethylamino)-propane (M2) and 1-(2,6-dimethylphenoxy)-2-(3-methoxy-4-hydroxyphenylethyl-amino)-propane (M1) respectively. beta-1-O-[3,5-dimethyl-4-[-2-methyl-2-(3,4-dimethoxy-phenylethylamino)- ethoxy]-phenyl]-glucuronic acid (M7, glucuronide of M3), beta-1-O-[2, 4-dimethyl-3-[2-methyl-2-(3, 4-dimethoxy-phenylethylamino)-ethoxy]-phenyl]-glucuronic acid (M8, glucuronide of M2) and beta-1-O-[2-methoxy-4-[1-methyl-2-(2, 6-dimethylphenoxy)-ethylamino-ethyl]-phenyl]-glucuronic acid (M9, glucuronide of M1) were the phase II metabolites of DDPH in rat bile.

  1. Permeability, storage and hydraulic diffusivity controlled by earthquakes (United States)

    Brodsky, E. E.; Fulton, P. M.; Xue, L.


    Earthquakes can increase permeability in fractured rocks. In the farfield, such permeability increases are attributed to seismic waves and can last for months after the initial earthquake. Laboratory studies suggest that unclogging of fractures by the transient flow driven by seismic waves is a viable mechanism. These dynamic permeability increases may contribute to permeability enhancement in the seismic clouds accompanying hydraulic fracking. Permeability enhancement by seismic waves could potentially be engineered and the experiments suggest the process will be most effective at a preferred frequency. We have recently observed similar processes inside active fault zones after major earthquakes. A borehole observatory in the fault that generated the M9.0 2011 Tohoku earthquake reveals a sequence of temperature pulses during the secondary aftershock sequence of an M7.3 aftershock. The pulses are attributed to fluid advection by a flow through a zone of transiently increased permeability. Directly after the M7.3 earthquake, the newly damaged fault zone is highly susceptible to further permeability enhancement, but ultimately heals within a month and becomes no longer as sensitive. The observation suggests that the newly damaged fault zone is more prone to fluid pulsing than would be expected based on the long-term permeability structure. Even longer term healing is seen inside the fault zone of the 2008 M7.9 Wenchuan earthquake. The competition between damage and healing (or clogging and unclogging) results in dynamically controlled permeability, storage and hydraulic diffusivity. Recent measurements of in situ fault zone architecture at the 1-10 meter scale suggest that active fault zones often have hydraulic diffusivities near 10-2 m2/s. This uniformity is true even within the damage zone of the San Andreas fault where permeability and storage increases balance each other to achieve this value of diffusivity over a 400 m wide region. We speculate that fault zones

  2. Seismic triggering of landslides, Part A: Field evidence from the Northern Tien Shan

    Directory of Open Access Journals (Sweden)

    H.-B. Havenith


    Full Text Available Landslides triggered by strong earthquakes often caused most of the global damage and most of all casualties related to the events, such as shown by the M = 7.7 Peru earthquake in 1970, by the M = 7.6 El Salvador earthquake in 2001 or by the M = 7.4 Khait (Tajikistan earthquake in 1949. The obvious impact of a landslide on the population is directly related to its movement. Yet, prediction of future failure potential and hence future risk to population is necessary in order to avoid further catastrophes and involves the analyses of the origin of seismic instability. The seismic landslide potential is mainly determined by the interaction between the regional seismic hazard and local geological conditions. At a local scale, seismic factors interfering with geological conditions can produce site-specific ground motions. The influence of such Site Effects on instability is the principal topic of this paper, which is divided into two parts, A and B. The present Part A is concerned with the correlation of field data with observed instability phenomena. Field data were obtained on mainly three landslide sites in the Northern Tien Shan Mountains in Kyrgyzstan, Central Asia. Geophysical prospecting, earthquake recordings, geological observation, trenching and geotechnical tests were the main investigation tools. The collected information gives an insight in the geological background of the slope failure and allows us to roughly infer failure mechanisms from field evidence. A detailed analysis of the susceptibility of a mechanism to specific geological conditions will be shown in Part B.

  3. Hyperfine splitting of the optical lines in the odd isotopes of uranium

    International Nuclear Information System (INIS)

    Gangrskij, Yu.P.; Zemlyanoj, S.G.; Markov, B.N.; Kul'dzhanov, B.K.


    The hyperfine structure was studied for two optical transitions in U between the ground state term 5 L 6 and the excited ones 7 M 7 and 7 L 6 . The method of laser resonance fluorescence in the atomic beam was used. The values of constants of hyperfine splitting-magnetic dipole and octupole, electric quadrupole were obtained for odd isotopes 223 U and 235 U. The connection of these constants and atomic and nuclear parameters is discussed. (author). 20 refs., 2 figs., 4 tabs

  4. Selection of Oil Coolers to Avoid Congealing (United States)


    from one fluid to another, there is a resistance to heat transfer l/ htSt . The total resistance to the flow of heat is the sum of thermal resistance equation is, htst hasa hoso n v \\hasa Vo/ (W The generally accepted equations for correlating heat...1 -. 1 htSt n v Da jS u Do Ho •a°l|.ki (5i2jLS 8oc3lc0/ W^ V \\SAafa; ^ fa^Z/yfij tM: (7) The heat-balance equation is. H

  5. United States Air Force Graduate Student Research Program. 1989 Program Technical Report. Volume 3 (United States)


    Dyca-l and :,W -sment iFME <Qt~c-Sn aop4 ica and txo glass Wh~omer L~rir-c cements: Shofu liin cement and XR iwncmqr lint rnM.7. 7i meL-in Vi traond...untiring efforts were greatly appreciated. 104-3 INTRODUCT IN: Pism 0_C Cval (Caulkli Cavalite (Kerr), (ES Ketac-bond applicap, Shofu lining cement, XR ...release of fluoride from the restored portions of the tooth to surrounding tooth structure. Teet- normally consist of hydroxyapatite c-ystals, After a

  6. Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia (United States)


    Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Minimally Differentiated Myeloid Leukemia (M0); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myelomonocytic Leukemia (M4); Childhood Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Fanconi Anemia; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Refractory Anemia With Ringed Sideroblasts; Secondary Myelodysplastic Syndromes; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

  7. Water quality assessment of Gautami-Godavari mangrove estuarine ecosystem of Andhra Pradesh, India during September 2001

    Digital Repository Service at National Institute of Oceanography (India)

    Tripathy, S.C.; Ray, A.K.; Patra, S.; Sarma, V.V.

    for the communities, more importantly they are believed to play a major role in supporting tropical estuarine and coastal food webs (Alongi and Christo?ersen 1992). It is a fact that the mangrove forests represent an impor- tant carbon and nutrient source... township (K1: Jagannathpuram canal) adjoining the Kakinada bay. High BOD with low DO values in Coringa river (M3{M7) mangrove systems may be due to contamination, either by the in?ow of wastes from terrestrial runo? or of anthropogenic in origin, and is a...

  8. Probabilistic tsunami hazard assessment based on the long-term evaluation of subduction-zone earthquakes along the Sagami Trough, Japan (United States)

    Hirata, K.; Fujiwara, H.; Nakamura, H.; Osada, M.; Ohsumi, T.; Morikawa, N.; Kawai, S.; Maeda, T.; Matsuyama, H.; Toyama, N.; Kito, T.; Murata, Y.; Saito, R.; Takayama, J.; Akiyama, S.; Korenaga, M.; Abe, Y.; Hashimoto, N.; Hakamata, T.


    For the forthcoming large earthquakes along the Sagami Trough where the Philippine Sea Plate is subducting beneath the northeast Japan arc, the Earthquake Research Committee(ERC) /Headquarters for Earthquake Research Promotion, Japanese government (2014a) assessed that M7 and M8 class earthquakes will occur there and defined the possible extent of the earthquake source areas. They assessed 70% and 0% 5% of the occurrence probability within the next 30 years (from Jan. 1, 2014), respectively, for the M7 and M8 class earthquakes. First, we set possible 10 earthquake source areas(ESAs) and 920 ESAs, respectively, for M8 and M7 class earthquakes. Next, we constructed 125 characterized earthquake fault models (CEFMs) and 938 CEFMs, respectively, for M8 and M7 class earthquakes, based on "tsunami receipt" of ERC (2017) (Kitoh et al., 2016, JpGU). All the CEFMs are allowed to have a large slip area for expression of fault slip heterogeneity. For all the CEFMs, we calculate tsunamis by solving a nonlinear long wave equation, using FDM, including runup calculation, over a nesting grid system with a minimum grid size of 50 meters. Finally, we re-distributed the occurrence probability to all CEFMs (Abe et al., 2014, JpGU) and gathered excess probabilities for variable tsunami heights, calculated from all the CEFMs, at every observation point along Pacific coast to get PTHA. We incorporated aleatory uncertainties inherent in tsunami calculation and earthquake fault slip heterogeneity. We considered two kinds of probabilistic hazard models; one is "Present-time hazard model" under an assumption that the earthquake occurrence basically follows a renewal process based on BPT distribution if the latest faulting time was known. The other is "Long-time averaged hazard model" under an assumption that earthquake occurrence follows a stationary Poisson process. We fixed our viewpoint, for example, on the probability that the tsunami height will exceed 3 meters at coastal points in next

  9. Radioimmunoassay of cholylglycine in serum

    International Nuclear Information System (INIS)

    Wakushima, Tadashi; Yamanishi, Yasuhito; Hirayama, Chisato


    Serum levels of cholylglycines (CG) were determined by radioimmunoassay and that of total bile acids (TBA) by enzymatic method. In normal subjects, serum levels of CG, TBA and CG/TBA ratio were 0.6 +- 0.4 μM, 7 +- 2 μM, and 0.08 +- 0.06, respectively. They were increased markedly in acute hepatitis and moderately in chronic hepatitis and cirrhosis. Thus, measurement of serum CG as compared with serum TBA appears to be a sensitive liver test. (author)

  10. A new probabilistic seismic hazard assessment for greater Tokyo (United States)

    Stein, R.S.; Toda, S.; Parsons, T.; Grunewald, E.; Blong, R.; Sparks, S.; Shah, H.; Kennedy, J.


    Tokyo and its outlying cities are home to one-quarter of Japan's 127 million people. Highly destructive earthquakes struck the capital in 1703, 1855 and 1923, the last of which took 105 000 lives. Fuelled by greater Tokyo's rich seismological record, but challenged by its magnificent complexity, our joint Japanese-US group carried out a new study of the capital's earthquake hazards. We used the prehistoric record of great earthquakes preserved by uplifted marine terraces and tsunami deposits (17 M???8 shocks in the past 7000 years), a newly digitized dataset of historical shaking (10 000 observations in the past 400 years), the dense modern seismic network (300 000 earthquakes in the past 30 years), and Japan's GeoNet array (150 GPS vectors in the past 10 years) to reinterpret the tectonic structure, identify active faults and their slip rates and estimate their earthquake frequency. We propose that a dislodged fragment of the Pacific plate is jammed between the Pacific, Philippine Sea and Eurasian plates beneath the Kanto plain on which Tokyo sits. We suggest that the Kanto fragment controls much of Tokyo's seismic behaviour for large earthquakes, including the damaging 1855 M???7.3 Ansei-Edo shock. On the basis of the frequency of earthquakes beneath greater Tokyo, events with magnitude and location similar to the M??? 7.3 Ansei-Edo event have a ca 20% likelihood in an average 30 year period. In contrast, our renewal (time-dependent) probability for the great M??? 7.9 plate boundary shocks such as struck in 1923 and 1703 is 0.5% for the next 30 years, with a time-averaged 30 year probability of ca 10%. The resulting net likelihood for severe shaking (ca 0.9g peak ground acceleration (PGA)) in Tokyo, Kawasaki and Yokohama for the next 30 years is ca 30%. The long historical record in Kanto also affords a rare opportunity to calculate the probability of shaking in an alternative manner exclusively from intensity observations. This approach permits robust estimates

  11. Computer Program Development Specification for Tactical Interface System. (United States)


    CNTL CNTL TO ONE VT~i.AE CR1 & TWELVE VT100 LCARD READER VIDEO TERMINALS, SIX LA12O) HARD- COPY TERMINALS, & VECTOR GRAPHICS RPO % TERMINAL 17%M DISK...this data into the TIS para - .. meter tables in the TISGBL common area. ICEHANDL will send test interface ICE to PSS in one of two modes: perio- dically...STOPCauss te TI sotwar toexit ,9.*9~ .r .~ * ~%.’h .9~ .. a .~ .. a. 1 , , p * % .’.-:. .m 7 P : SDSS-MMP-BI ." 31 July 1981 TCL commands authorized

  12. Symposium on Molecular Spectroscopy (40th) Held at Columbus, Ohio on 17-21 June 1985. (United States)



  13. VizieR Online Data Catalog: Chemical analysis of CH stars. II. (Karinkuzhi+, 2015) (United States)

    Karinkuzhi, D.; Goswami, A.


    Low-resolution spectra of these objects obtained from 2m Himalayan Chandra Telescope at the Indian Astronomical Observatory, Hanle using HFOSC clearly show strong features due to carbon. HFOSC is an optical imager cum spectrograph for conducting low- and medium-resolution grism spectroscopy ( High-resolution spectra necessary for abundance analyses of the programme stars are taken from the ELODIE archive (Moultaka et al. 2004PASP..116..693M). (7 data files).

  14. Health and Safety Plan Data Item A009. Hamilton Army Airfield, Novato, California (United States)


    also positively or negatively effect the measured results. Calibration and maintenance will be performed in accordance with the manufacturer’s...allows reading of the scale and operation of the knobs. The sensors can be partially wrapped, keeping the sensor tip and discharge port clear. The...01111 a -1,1 "I NMw~ 0: a ’MaWsif0II A *t wo ON SWIMm SOL egj _’ ~ m e w - e m sm FLWAAw my wow" "Nw CA 1,~ On a- i M 7 EsuMe wow urn to etmime womo

  15. On optical spectra of the NGC 6677 galaxy and the adjacent bright compact object

    International Nuclear Information System (INIS)

    Chuvaev, K.K.


    Spectral observations of NGC 6677 galaxy and the adjacent object carried out during six nights on the spectrograph with the image tube of 2.6-m Shain telescope showed, that the bright compact object is a star belonging to our galaxy but not an active galaxy. The NGC 6677 galaxy has sufficiently rich emission spectrum. On the basis of measured values of red shift Z, the inclination and the extent of emission lines, the mass of the galaxy has been estimated (M=7x10 9 M Sun )

  16. Effects of Synchronous Rolling on Microstructure, Hardness, and Wear Resistance of Laser Multilayer Cladding (United States)

    Zhao, W.; Zha, G. C.; Xi, M. Z.; Gao, S. Y.


    A synchronous rolling method was proposed to assist laser multilayer cladding, and the effects of this method on microstructure, microhardness, and wear resistance were studied. Results show that the microstructure and mechanical properties of the traditional cladding layer exhibit periodic inhomogeneity. Synchronous rolling breaks the columnar dendrite crystals to improve the uniformity of the organization, and the residual plastic energy promotes the precipitation of strengthening phases, as CrB, M7C3, etc. The hardness and wear resistance of the extruded cladding layer increase significantly because of the grain refinement, formation of dislocations, and dispersion strengthening. These positive significances of synchronous rolling provide a new direction for laser cladding technology.

  17. Sports Medicine and Rehabilitation Team Clinic: Comparative Model Analysis of Navy and Marine Corps Options (United States)


    Epididimitis 820408 F 3 Bilatet PFS/Poss Right SFX 820913 F 1 Grief, Self Harm Threat 820203 M I Bilate Plantar Fascitis 810415 F 1 PFS 771105 M 2 ACL Tear...820315 M 2 Right Radius/Unlar Fracture 800319 M 1 Allergies 800408 M 3 Right Knee Pain 800722 M 1 Right Plantar Fascitis 810506 M 1 Dental, Abscess 810720...M 7 Bilateral Plantar Fasciitis 820226 M 2 Left IT Band Syndrome 811227 F 6 Left Foot Pain 730512 M 5 Bilateral Foot Pain/Stress Fracture SMART

  18. Statistical Methods for Solar Flare Probability Forecasting. (United States)


    TAu C a -. 66M7. stNIr’ICANCe .0000 -SOMEOSIS 0 IASYMEMTIC- a -. i55 MITM fLARPE- -D"NOroMT, *-.255S WITH APPLONG OCSEOE4T. 8OLa sSES 0 (S "MERrCTAX 0...8217 q~ - - -WS S0MEOSNSO 0 ASYHNETP1CI * 291312UI HLARE4 OPENS(N, - * 49645 MITM *Ec$POT OWITN E f. ONIRSVS 0 ESYHNETRICI a .36652 0I"El of HISSING ONSERVATIONS t 19 76 ILMEI

  19. P-8A Poseidon HAZMAT Identification and Chemical Mapping Strategy (United States)


    34U!~ .,,r;,; d . td !te:n:.J.e3 :2’’ ~ .~ . c 5. 16 raa/10 1•: ’XIl .tust’ ’!!Ti-P- 11.)/lo!l 19.’ll < •• .., ’ppill ’·’ ;p. c :.. :u 113.󈧎 l.S...Zone 400 Po·wor Pl ant M7~JOC’ £ono ’>UV • ""’"fill• L.-.n ~VI Zul "=! 600 • ’MI’\\1, ftl \\, llj ~jor Zone 700 ~Ŕ Gear & LG ~ llr.tJor Cono tAIU

  20. Gaithersburg Nike Control and Launch Area Preliminary Assessment/Site Inspection Gaithersburg, Maryland (United States)



  1. Role of Infection Due to Campylobacter jejuni in the Initiation of Guillain-Barre Syndrome (United States)


    21 Mild 6th-ner.e palks at 3 mo England. 1984 127]: 16/M 10 Complete recoer, at 6 mo England. 1985 1411: 27/M 7 Complete recoery r with minor delicits...14 Canes required for walking at 6 mo 83/F 7 Bedridden at 3 y Japan. 1991 1321 7/M ? Complete recovery with minor deficits 9/M 6 Complete Acta Neuriil Scand 1986.73:394-4o2. China 1301l 32 41 LtISA 14. T rahelsi M. Mokrani R . Beninaceur B. Pok radiculon~vrites aigu6s de United

  2. Summary of Synoptic Meteorological Observations. North American Coastal Marine Areas - Revised. Atlantic and Gulf Coasts. Volume I. Revised. Area 1 - Belle Isle Strait. Area 2 - Osv Bravo. Area 3 - NE Newfoundland Coast. Area 4 - SE Newfoundland Coast. Area 5 - Placentia Bay South. Area 6 - Cabot Strait. Area 7 - Anticosti Island (United States)



  3. Evaluation of Self-Applied Tourniquets for Combat Applications, Second Phase (United States)


    the dicrotic notch in the IPG pulse, 5. Maximum amplitude of the postdicrotic segment of the IPG pulse, 6. Peak of the ECG QRS complex immediately after... dicrotic notch (Wu, 1992). TOUT (s) Time of excess venous outflow = (tM7 - tM4), (B10) the time period from the dicrotic notch until the end of the IPG...nonadherence, inability to obtain steady IPG tracings, or other technical factors . The percentage of IPG data lost (4%) was less than that in the

  4. Characterizing distributions of surface ozone and its impact on grain production in China, Japan and South Korea: 1990 and 2020 (United States)

    Wang, Xiaoping; Mauzerall, Denise L.

    Using an integrated assessment approach, we evaluate the impact that surface O 3 in East Asia had on agricultural production in 1990 and is projected to have in 2020. We also examine the effect that emission controls and the enforcement of environmental standards could have in increasing grain production in China. We find that given projected increases in O 3 concentrations in the region, East Asian countries are presently on the cusp of substantial reductions in grain production. Our conservative estimates, based on 7- and 12-h mean (M7 or M12) exposure indices, show that due to O 3 concentrations in 1990 China, Japan and South Korea lost 1-9% of their yield of wheat, rice and corn and 23-27% of their yield of soybeans, with an associated value of 1990US 3.5, 1.2 and 0.24 billion, respectively. In 2020, assuming no change in agricultural production practices and again using M7 and M12 exposure indices, grain loss due to increased levels of O 3 pollution is projected to increase to 2-16% for wheat, rice and corn and 28-35% for soybeans; the associated economic costs are expected to increase by 82%, 33%, and 67% in 2020 over 1990 for China, Japan and South Korea, respectively. For most crops, the yield losses in 1990 based on SUM06 or W126 exposure indices are lower than yield losses estimated using M7 or M12 exposure indices in China and Japan but higher in South Korea; in 2020, the yield losses based on SUM06 or W126 exposure indices are substantially higher for all crops in all three countries. This is primarily due to the nature of the cumulative indices which weight elevated values of O 3 more heavily than lower values. Chinese compliance with its ambient O 3 standard in 1990 would have had a limited effect in reducing the grain yield loss caused by O 3 exposure, resulting in only US 0.2 billion of additional grain revenues, but in 2020 compliance could reduce the yield loss by one third and lead to an increase of US$ 2.6 (M7 or M12) -27 (SUM06) billion in

  5. Extended abstract: ergodic magnetic limiter experiments on TEXT with a 7/3 resonance

    International Nuclear Information System (INIS)

    deGrassie, J.S.; Ohyabu, N.; Brooks, N.H.


    The ergodic magnetic limiter coils on TEXT have been reconfigured to produce the primary helical perturbation resonance at m = 7 / n = 3. The experiments continue to demonstrate that the weak resonant perturbations modify the edge conditions in keeping with model predictions. We observe a reduction in the intrinsic impurity levels accompanying the helical current pulse, presumably the result of a reduction in the electron temperature in the edge. Heat follows the perturbed field lines to the limiter, generating heat load patterns which reflect the geometry of a magnetic island - limiter intersection. A strong spatial modulation of the electron density in the scrape-off-layer also reflects the helical mode structure

  6. Earthquake-Induced Liquefaction of Confined Soil Zones: A Centrifuge Study (United States)


    8217. 4.2 Pore pressure transducers (PPT) Pore pressures in the saturated soil were monitored by Druck PDCR 81 pore pressure transducers. This type of pore...PPT5406 -20 MTn-23.3 2 3 4 5 6 7 a 2 10 II 12 Mo, 34 .8 PPT6270 20~ Mlm=-I .2 1 2 3 4 5 6 8 a 1 0 II 12 4 M....7 0 PPT6263 A 3d Moa20.S PPT6260 7 -0 1 2 3

  7. The interaction of substituted benzamides with brain benzodiazepine binding sites in vitro.


    Horton, R. W.; Lowther, S.; Chivers, J.; Jenner, P.; Marsden, C. D.; Testa, B.


    1. The interaction of substituted benzamides with brain benzodiazepine (BDZ) binding sites was examined by their ability to displace [3H]-flunitrazepam ([3H]-FNM) from specific binding sites in bovine cortical membranes in vitro. 2. Clebopride, Delagrange 2674, Delagrange 2335 and BRL 20627 displayed concentration-dependent displacement of [3H]-FNM with IC50 values of 73 nM, 132 nM, 7.7 microM and 5.9 microM, respectively. Other substituted benzamides including metoclopramide, sulpiride, tiap...

  8. High-spin yrast isomers in 211Rn and 212Rn with enhanced E3 decays

    International Nuclear Information System (INIS)

    Dracoulis, G.D.; Byrne, A.P.; Fabricius, B.


    New isomeric states with J π =69/2 + ,τ m = 13 (1) ns in 211 Rn and J π =33 - ,τ m = 7(1) ns in 212 Rn have been identified. They decay by enchanced E3 transitions with strengths of 33(3) and 43(6) single particle units to the known 63/2 - and 30 + isomers 211 Rn and 212 Rn, respectively. The excitation energies and transition strengths agree well with predictions of the multi-particle, octupole-vibration coupled model. 13 refs., 2 tabs., 3 figs

  9. Earthquake Risk Mitigation in the Tokyo Metropolitan area (United States)

    Hirata, N.; Sakai, S.; Kasahara, K.; Nakagawa, S.; Nanjo, K.; Panayotopoulos, Y.; Tsuruoka, H.


    Seismic disaster risk mitigation in urban areas constitutes a challenge through collaboration of scientific, engineering, and social-science fields. Examples of collaborative efforts include research on detailed plate structure with identification of all significant faults, developing dense seismic networks; strong ground motion prediction, which uses information on near-surface seismic site effects and fault models; earthquake resistant and proof structures; and cross-discipline infrastructure for effective risk mitigation just after catastrophic events. Risk mitigation strategy for the next greater earthquake caused by the Philippine Sea plate (PSP) subducting beneath the Tokyo metropolitan area is of major concern because it caused past mega-thrust earthquakes, such as the 1703 Genroku earthquake (magnitude M8.0) and the 1923 Kanto earthquake (M7.9) which had 105,000 fatalities. A M7 or greater (M7+) earthquake in this area at present has high potential to produce devastating loss of life and property with even greater global economic repercussions. The Central Disaster Management Council of Japan estimates that the M7+ earthquake will cause 11,000 fatalities and 112 trillion yen (about 1 trillion US$) economic loss. This earthquake is evaluated to occur with a probability of 70% in 30 years by the Earthquake Research Committee of Japan. In order to mitigate disaster for greater Tokyo, the Special Project for Earthquake Disaster Mitigation in the Tokyo Metropolitan Area (2007-2011) was launched in collaboration with scientists, engineers, and social-scientists in nationwide institutions. The results that are obtained in the respective fields will be integrated until project termination to improve information on the strategy assessment for seismic risk mitigation in the Tokyo metropolitan area. In this talk, we give an outline of our project as an example of collaborative research on earthquake risk mitigation. Discussion is extended to our effort in progress and

  10. 1982 Annual Typhoon Report (United States)


    NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Tupaz, Jesus B. ; Hinman, Jr., Kendall G. ; Morss, Dean A. ; 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK...s path, schools, industries and hospitals were damaged or destroyed. Yet despike this extensive destruction, there were just ?ive deaths reported in a...7aBJ”a 7eerm 7e0m 7aerm 7eetEl 7amEl 7em13 ? Bom 7EiElm B 9 072205 092808 3E32 CIRCULfiR 8 52 28 le 1 3833 2823 C IRCULRR 2032 C IRCULRR 10 11 12 892386

  11. Software and Systems Test Track Architecture and Concept Definition (United States)


    Light 11.0 11.0 11.0 ASC Flex Free Software Foundation 2.5.31 2.5.31 2.5.31 ASC Fluent Fluent Inc. 6.2.26 6.2.26 6.2.26 6.2.26 ASC FMD ...11 ERDC Fluent Fluent 6.2.16 ERDC Fortran 77/90 compiler Compaq/Cray/SGI 7.4 7.4.3m 7.4.4m 5.6 ERDC FTA Platform 1.1 1.1 1.1 ERDC GAMESS

  12. A nano capacitor with graphene electrodes and Methane - (h-BN)insulator


    Farrokh Roya Nikmaram


    Methan has a large potential to adsorb and diffuse among h-BN and graphene surfaces as the suitable dielectric. With this background the nanoscale dielectric capacitors have been widely studied due to their ability to store a high amount of energy. In this research, I have modeled one which is composed of two graphene layers including insulating medium of a h-BN layers which are filed out (Methane)n,m {n=m=7). It has been indicated thatthe Methane moleculeis the suitable gas for hetero-struct...

  13. mRNA processing in yeast

    International Nuclear Information System (INIS)

    Stevens, A.


    Investigations in this laboratory center on basic enzymatic reactions of RNA. Still undefined are reactions involved in the conversion of precursors of mRA (pre-mRNA) to mRNA in eukaryotes. The pre-mRNA is called heterogeneous nuclear RNA and is 2 to 6 times larger than mRNA. The conversion, called splicing, involves a removal of internal sequences called introns by endoribonuclease action followed by a rejoining of the 3'- and 5'-end fragments, called exons, by ligating activity. It has not been possible yet to study the enzymes involved in vitro. Also undefined are reactions involved in the turnover or discarding of certain of the pre-mRNA molecules. Yeast is a simple eukaryote and may be expected to have the same, but perhaps simpler, processing reactions as the higher eukaryotes. Two enzymes involved in the processing of pre-mRNA and mRNA in yeast are under investigation. Both enzymes have been partially purified from ribonucleoprotein particles of yeast. The first is a unique decapping enzyme which cleaves [ 3 H]m 7 Gppp [ 14 C]RNA-poly (A) of yeast, yielding [ 3 H]m 7 GDP and is suggested by the finding that the diphosphate product, m 7 GpppA(G), and UDP-glucose are not hydrolyzed. The second enzyme is an endoribonuclease which converts both the [ 3 H] and [ 14 C] labels of [ 3 H]m 7 Gppp[ 14 C]RNA-poly(A) from an oligo(dT)-cellulose bound form to an unbound, acid-insoluble form. Results show that the stimulation involves an interaction of the labeled RNA with the small nuclear RNA. The inhibition of the enzyme by ethidium bromide and its stimulation by small nuclear RNA suggest that it may be a processing ribonuclease, requiring specific double-stranded features in its substrate. The characterization of the unique decapping enzyme and endoribonuclease may help to understand reactions involved in the processing of pre-mRNA and mRNA in eukaryotes

  14. Evidence for Ancient Mesoamerican Earthquakes (United States)

    Kovach, R. L.; Garcia, B.


    Evidence for past earthquake damage at Mesoamerican ruins is often overlooked because of the invasive effects of tropical vegetation and is usually not considered as a casual factor when restoration and reconstruction of many archaeological sites are undertaken. Yet the proximity of many ruins to zones of seismic activity would argue otherwise. Clues as to the types of damage which should be soughtwere offered in September 1999 when the M = 7.5 Oaxaca earthquake struck the ruins of Monte Alban, Mexico, where archaeological renovations were underway. More than 20 structures were damaged, 5 of them seriously. Damage features noted were walls out of plumb, fractures in walls, floors, basal platforms and tableros, toppling of columns, and deformation, settling and tumbling of walls. A Modified Mercalli Intensity of VII (ground accelerations 18-34 %b) occurred at the site. Within the diffuse landward extension of the Caribbean plate boundary zone M = 7+ earthquakes occur with repeat times of hundreds of years arguing that many Maya sites were subjected to earthquakes. Damage to re-erected and reinforced stelae, walls, and buildings were witnessed at Quirigua, Guatemala, during an expedition underway when then 1976 M = 7.5 Guatemala earthquake on the Motagua fault struck. Excavations also revealed evidence (domestic pttery vessels and skeleton of a child crushed under fallen walls) of an ancient earthquake occurring about the teim of the demise and abandonment of Quirigua in the late 9th century. Striking evidence for sudden earthquake building collapse at the end of the Mayan Classic Period ~A.D. 889 was found at Benque Viejo (Xunantunich), Belize, located 210 north of Quirigua. It is argued that a M = 7.5 to 7.9 earthquake at the end of the Maya Classic period centered in the vicinity of the Chixoy-Polochic and Motagua fault zones cound have produced the contemporaneous earthquake damage to the above sites. As a consequences this earthquake may have accelerated the

  15. Analysis of metal fuel transient overpower experiments with the SAS4A accident analysis code

    International Nuclear Information System (INIS)

    Tentner, A.M.; Kalimullah; Miles, K.J.


    The results of the SAS4A analysis of the M7 TREAT Metal fuel experiment are presented. New models incorporated in the metal fuel version of SAS4A are described. The computational results are compared with the experimental observations and this comparison is used in the interpretation of physical phenomena. This analysis was performed using the integrated metal fuel SAS4A version and covers a wide range of events, providing an increased degree of confidence in the SAS4A metal fuel accident analysis capabilities

  16. Impact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMT. (United States)

    Canaani, Jonathan; Beohou, Eric; Labopin, Myriam; Socié, Gerard; Huynh, Anne; Volin, Liisa; Cornelissen, Jan; Milpied, Noel; Gedde-Dahl, Tobias; Deconinck, Eric; Fegueux, Nathalie; Blaise, Didier; Mohty, Mohamad; Nagler, Arnon


    The French, American, and British (FAB) classification system for acute myeloid leukemia (AML) is extensively used and is incorporated into the AML, not otherwise specified (NOS) category in the 2016 WHO edition of myeloid neoplasm classification. While recent data proposes that FAB classification does not provide additional prognostic information for patients for whom NPM1 status is available, it is unknown whether FAB still retains a current prognostic role in predicting outcome of AML patients undergoing allogeneic stem cell transplantation. Using the European Society of Blood and Bone Marrow Transplantation registry we analyzed outcome of 1690 patients transplanted in CR1 to determine if FAB classification provides additional prognostic value. Multivariate analysis revealed that M6/M7 patients had decreased leukemia free survival (hazard ratio (HR) of 1.41, 95% confidence interval (CI), 1.01-1.99; P = .046) in addition to increased nonrelapse mortality (NRM) rates (HR, 1.79; 95% CI, 1.06-3.01; P = .028) compared with other FAB types. In the NPM1 wt AML, NOS cohort, FAB M6/M7 was also associated with increased NRM (HR, 2.17; 95% CI, 1.14-4.16; P = .019). Finally, in FLT3-ITD + patients, multivariate analyses revealed that specific FAB types were tightly associated with adverse outcome. In conclusion, FAB classification may predict outcome following transplantation in AML, NOS patients. © 2017 Wiley Periodicals, Inc.

  17. Structure and tectonics of the Main Himalayan Thrust and associated faults from recent earthquake and seismic imaging studies using the NAMASTE array (United States)

    Karplus, M. S.; Pant, M.; Velasco, A. A.; Nabelek, J.; Kuna, V. M.; Sapkota, S. N.; Ghosh, A.; Mendoza, M.; Adhikari, L. B.; Klemperer, S. L.


    The India-Eurasia collision zone presents a significant earthquake hazard, as demonstrated by the recent, devastating April 25, 2015 M=7.8 Gorkha earthquake and the following May 12, 2015 M=7.3 earthquake. Important questions remain, including distinguishing possible geometries of the Main Himalayan Thrust (MHT), the role of other regional faults, the crustal composition and role of fluids in faulting, and the details of the rupture process, including structural causes and locations of rupture segmentation both along-strike and down-dip. These recent earthquakes and their aftershocks provide a unique opportunity to learn more about this collision zone. In June 2015, funded by NSF, we deployed the Nepal Array Measuring Aftershock Seismicity Trailing Earthquake (NAMASTE) array of 46 seismic stations distributed across eastern and central Nepal, spanning the region with most of the aftershocks. This array remained in place for 11 months from June 2015 to May 2016. We combine new results from this aftershock network in Nepal with previous geophysical and geological studies across the Himalaya to derive a new understanding of the tectonics of the Himalaya and southern Tibet in Nepal and surrounding countries. We focus on structure and composition of the Main Himalayan Thrust and compare this continent-continent subduction megathrust with megathrusts in other subduction zones.

  18. Natural and semi-synthetic clerodanes of Croton cajucara and their cytotoxic effects against ehrlich carcinoma and human K562 leukemia cells

    Energy Technology Data Exchange (ETDEWEB)

    Maciel, Maria Aparecida M. [Universidade Federal do Rio Grande do Norte, Natal, RN (Brazil). Dept. de Quimica; Martins, Jenilce R.; Pinto, Angelo C.; Kaiser, Carlos R. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Inst. de Quimica; Esteves-Souza, Andressa; Echevarria, Aurea [Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ (Brazil). Dept. de Quimica]. E-mail:


    The clerodane-type diterpene, trans-dehydrocrotonin (1) the major component of Croton cajucara has shown striking correlation with its therapeutic use in traditional folk medicine. Phytochemical investigations led to the isolation of the metabolites 1, cajucarinolide (6), isocajucarinolide (7), trans-crotonin (2), trans-cajucarin B (3), cis-cajucarin B (4), trans-cajucarin A (5), N-methyltyrosine, vanillic acid and 4-hydroxy-benzoic acid. 6 and 7 were synthesized in good yield by regiospecific oxidation of 1 using singlet-oxygen. All clerodanes were studied for their cytotoxic effects against human K562 leukemia and Ehrlich carcinoma cells. Ehrlich carcinoma assays with IC{sub 50} = 166 {mu}M (1), 164 {mu}M (2), 65 {mu}M (6) and 10 {mu}M (7) related to cell growth inhibitory effects were dose dependent. Furthermore, moderate cytotoxic activity against K562 leukemia cells was observed with IC{sub 50} = 38 {mu}M (3), 33 {mu}M (5), 36 {mu}M (6) and 43 {mu}M (7). The semi-synthetic 2, 6 and 7 showed similar results when compared to the corresponding natural clerodanes. (author)

  19. Thyroid Uptake Measurement System

    International Nuclear Information System (INIS)

    Nguyen Duc Tuan; Nguyen Thi Bao My; Nguyen Van Sy


    The NED-UP.M7 is a complete thyroid uptake and analysis system specifically designed for nuclear medicine. Capable of performing a full range of studies this system provides fast, accurate results for Uptake Studies. The heart of the NED-UP.M7 is a microprocessor-controlled 2048 channel Compact Multi-Channel Analyzer, coupled to a 2 inch x 2 inch NaI(Tl) detector with a USB personal computer interface. The system offers simple, straight-forward operation using pre-programmed isotopes, and menudriven prompts to guide the user step by step through each procedure. The pre-programmed radionuclides include I-123, I-125, I-131, Tc-99m and Cs-137. The user-defined radionuclides also allow for isotope identification while the printer provides hard copy printouts for patient and department record keeping. The included software program running on PC (Windows XP-based) is a user friendly program with menudriven and graphic interface for easy controlling the system and managing measurement results of patient on Excel standard form. (author)

  20. Carbide Precipitation in 2.25 Cr-1 Mo Bainitic Steel: Effect of Heating and Isothermal Tempering Conditions (United States)

    Dépinoy, Sylvain; Toffolon-Masclet, Caroline; Urvoy, Stéphane; Roubaud, Justine; Marini, Bernard; Roch, François; Kozeschnik, Ernst; Gourgues-Lorenzon, Anne-Françoise


    The effect of the tempering heat treatment, including heating prior to the isothermal step, on carbide precipitation has been determined in a 2.25 Cr-1 Mo bainitic steel for thick-walled applications. The carbides were identified using their amount of metallic elements, morphology, nucleation sites, and diffraction patterns. The evolution of carbide phase fraction, morphology, and composition was investigated using transmission electron microscopy, X-ray diffraction, as well as thermodynamic calculations. Upon heating, retained austenite into the as-quenched material decomposes into ferrite and cementite. M7C3 carbides then nucleate at the interface between the cementite and the matrix, triggering the dissolution of cementite. M2C carbides precipitate separately within the bainitic laths during slow heating. M23C6 carbides precipitate at the interfaces (lath boundaries or prior austenite grain boundaries) and grow by attracting nearby chromium atoms, which results in the dissolution of M7C3 and, depending on the temperature, coarsening, or dissolution of M2C carbides, respectively.

  1. Radon observation for earthquake prediction

    Energy Technology Data Exchange (ETDEWEB)

    Wakita, Hiroshi [Tokyo Univ. (Japan)


    Systematic observation of groundwater radon for the purpose of earthquake prediction began in Japan in late 1973. Continuous observations are conducted at fixed stations using deep wells and springs. During the observation period, significant precursory changes including the 1978 Izu-Oshima-kinkai (M7.0) earthquake as well as numerous coseismic changes were observed. At the time of the 1995 Kobe (M7.2) earthquake, significant changes in chemical components, including radon dissolved in groundwater, were observed near the epicentral region. Precursory changes are presumably caused by permeability changes due to micro-fracturing in basement rock or migration of water from different sources during the preparation stage of earthquakes. Coseismic changes may be caused by seismic shaking and by changes in regional stress. Significant drops of radon concentration in groundwater have been observed after earthquakes at the KSM site. The occurrence of such drops appears to be time-dependent, and possibly reflects changes in the regional stress state of the observation area. The absence of radon drops seems to be correlated with periods of reduced regional seismic activity. Experience accumulated over the two past decades allows us to reach some conclusions: 1) changes in groundwater radon do occur prior to large earthquakes; 2) some sites are particularly sensitive to earthquake occurrence; and 3) the sensitivity changes over time. (author)

  2. Natural and semi-synthetic clerodanes of Croton cajucara and their cytotoxic effects against ehrlich carcinoma and human K562 leukemia cells

    International Nuclear Information System (INIS)

    Maciel, Maria Aparecida M.; Martins, Jenilce R.; Pinto, Angelo C.; Kaiser, Carlos R.; Esteves-Souza, Andressa; Echevarria, Aurea


    The clerodane-type diterpene, trans-dehydrocrotonin (1) the major component of Croton cajucara has shown striking correlation with its therapeutic use in traditional folk medicine. Phytochemical investigations led to the isolation of the metabolites 1, cajucarinolide (6), isocajucarinolide (7), trans-crotonin (2), trans-cajucarin B (3), cis-cajucarin B (4), trans-cajucarin A (5), N-methyltyrosine, vanillic acid and 4-hydroxy-benzoic acid. 6 and 7 were synthesized in good yield by regiospecific oxidation of 1 using singlet-oxygen. All clerodanes were studied for their cytotoxic effects against human K562 leukemia and Ehrlich carcinoma cells. Ehrlich carcinoma assays with IC 50 = 166 μM (1), 164 μM (2), 65 μM (6) and 10 μM (7) related to cell growth inhibitory effects were dose dependent. Furthermore, moderate cytotoxic activity against K562 leukemia cells was observed with IC 50 = 38 μM (3), 33 μM (5), 36 μM (6) and 43 μM (7). The semi-synthetic 2, 6 and 7 showed similar results when compared to the corresponding natural clerodanes. (author)

  3. Electrical streaming potential precursors to catastrophic earthquakes in China

    Directory of Open Access Journals (Sweden)

    F. Qian


    Full Text Available The majority of anomalies in self-potential at 7 stations within 160 km from the epicentre showed a similar pattern of rapid onset and slow decay during and before the M 7.8 Tangshan earthquake of 1976. Considering that some of these anomalies associated with episodical spouting from boreholes or the increase in pore pressure in wells, observed anomalies are streaming potential generated by local events of sudden movements and diffusion process of high-pressure fluid in parallel faults. These transient events triggered by tidal forces exhibited a periodic nature and the statistical phenomenon to migrate towards the epicentre about one month before the earthquake. As a result of events, the pore pressure reached its final equilibrium state and was higher than that in the initial state in a large enough section of the fault region. Consequently, local effective shear strength of the material in the fault zone decreased and finally the catastrophic earthquake was induced. Similar phenomena also occurred one month before the M 7.3 Haichen earthquake of 1975. Therefore, a short term earthquake prediction can be made by electrical measurements, which are the kind of geophysical measurements most closely related to pore fluid behaviors of the deep crust.

  4. Different controls on sedimentary organic carbon in the Bohai Sea: River mouth relocation, turbidity and eutrophication (United States)

    Xu, Yunping; Zhou, Shangzhe; Hu, Limin; Wang, Yinghui; Xiao, Wenjie


    The extractable lipids and bulk organic geochemical parameters in three sediment cores (M-1, M-3 and M-7) from southern, central and northern Bohai Sea were analyzed in order to reconstruct environmental changes since 1900. The C/N ratio and multiple biomarkers (e.g., C27 + C29 + C31n-alkanes, C24 + C26 + C28n-alkanols, branched versus isoprenoid tetraether index) suggest more terrigenous organic carbon (OC) inputs in southern Bohai Sea. The abrupt changes of biomarker indicators in core M-1 are generally synchronous with the Yellow River mouth relocation events (e.g., 1964, 1976 and 1996), suggesting the distance to the river mouth being an important factor for sedimentary OC dispersal in the southern Bohai Sea. However, in cores M-3 and M-7, terrigenous biomarkers (i.e., BIT) show a long-term declining trend, consistent with a continuous reduction of the Yellow River sediment load, whereas marine biomarkers such as cholesterol, brassicasterol and dinosterol dramatically increased post-1980, apparently related to human-induced eutrophication in the Bohai Sea. Our study suggests different controlling factors on sedimentary OC distribution in the southern (high turbidity) and other parts (less turbidity) of the Bohai Sea, which should be considered for interpretation of paleoenvironments and biogeochemical processes in the river dominated margins that are hotspots of the global carbon cycling.

  5. Osmotic stress regulates the strength and kinetics of sugar binding to the maltoporin channel

    International Nuclear Information System (INIS)

    Gurnev, Philip A; Bezrukov, Sergey M; Harries, Daniel; Adrian Parsegian, V


    We study the effect of osmotic stress, exerted by salts, on carbohydrate binding to the sugar-specific bacterial channel maltoporin. When the channel is reconstituted into planar lipid bilayers, single events of its occlusion by sugar are seen as transient interruptions in the flow of small ions. We find that, for most salts, changes in the free energy of maltoporin-sugar binding vary linearly with solution osmotic pressure. Such a change in binding with solution osmolarity indicates that for each salt a constant number of salt-excluding water molecules is released upon sugar-maltoporin association at all salt concentrations. We find that larger numbers of water molecules are released upon binding of the cyclic carbohydrate β-cyclodextrin (CD) than upon binding of the corresponding linear homologue maltoheptaose (m7). Remarkably, the extent to which salts affect the binding constants and rates depends sensitively on the type of salt; dehydration in solutions of different anions corresponds to the Hofmeister series. In sodium sulfate solutions, CD and m7 respectively release about 120 and 35 salt-excluding water molecules; in sodium chloride solutions, 35 and 15 waters. No water release is observed with sodium bromide. Finally, by adding adamantane, known to form an inclusion complex with CD, we can infer that CD not only dehydrates but also undergoes a conformational change upon binding to the channel. As a practical outcome, our results also demonstrate how osmotic stress can improve single-molecule detection of different solutes using protein-based nanopores.

  6. The Investigation of Property of Radiation and Absorbed of Infrared Lights of the Biological Tissues (United States)

    Pang, Xiao-Feng; Deng, Bo; Xiao, He-Lan; Cai, Guo-Ping


    The properties of absorption of infrared light for collagen, hemoglobin, bivine serum albumen (BSA) protein molecules with α- helix structure and water in the living systems as well as the infrared transmission spectra for person’s skins and finger hands of human body in the region of 400-4000 cm-1 (i.e., wavelengths of 2-20 μm) have been collected and determined by using a Nicolet Nexus 670 FT-IR Spectrometer, a Perkin Elmer GX FT-IR spectrometer, an OMA (optical multichannel analysis) and an infrared probe systems, respectively. The experimental results obtained show that the protein molecules and water can all absorb the infrared lights in the ranges of 600-1900 cm-1 and 2900-3900 cm-l, but their properties of absorption are somewhat different due to distinctions of their structure and conformation and molecular weight. We know from the transmission spectra of person’s finger hands and skin that the infrared lights with wavelengths of 2 μm-7 μm can not only transmit over the person’s skin and finger hands, but also be absorbed by the above proteins and water in the living systems. Thus, we can conclude from this study that the human beings and animals can absorb the infrared lights with wavelengths of 2 μm-7 μm.

  7. Synthesis of laser beam rapidly solidified novel surfaces on D2 tool steel

    International Nuclear Information System (INIS)

    Ahmed, B.A.; Rizwan, K.F.; Minhas, J.A.; Waheed-ul-Haq, S.; Shahid, M.


    Surface layer of D2 tool steel was subjected to laser surface melting using continuous wave 2.5 kW CO/sub 2/ laser in point source melting mode. The processing parameters were varied to achieve a uniform depth of around 2 mm. Microstructural study revealed epitaxial growth of fine dendritic structure with secondary dendrite arm spacing in the range of 20-25 mu m. The phases in the parent annealed sample were BCC ferrite and chromium rich M7C3 carbide. The major phase after laser treatment was austenite and M7C3. The average hardness of annealed sample was 195 HV which increased to 410 HV after laser melting. Corrosion studies in 2% HCl solution exhibited a drastic improvement in corrosion resistance in laser treated samples. Improvement in properties is attributed to the refinement and uniformity of microstructure in the rapidly solidified surface. The case of a moving heat source was subjected to computer aided simulation to predict the melt depth at different processing conditions in point source melting mode. The calculated depths using the model, in ABAQUS software was found in good agreement with the experimental data. (author)

  8. Impact of Telework On the Perceived Work Environment of Older Workers

    Directory of Open Access Journals (Sweden)

    Arvola René


    Full Text Available Telework has become a natural part of regular work life of employees who use the information communication technology (ICT. Telework has a potential to support postponing retirement for mental workers. The objective of this research was to find out interaction between senior employees′ teleworking and well-being. The main research question was - can telework improve elderly employees′ well-being? Over 100 respondents from different areas in mental work were involved in a quantitative survey. The results of a conducted survey showed that telework is exaggerated to some extent as teleworkers’ well-being (M = 7.79; SD = 1.28 does not diverge from non-teleworkers′ wellbeing (M = 7.75; SD = 1.40. However, telework can be neither underestimated nor taken as interchangeable with traditional work. Therefore, it is necessary to pay attention to telework as a different way of working with its specialties. Systematic approach to telework enables companies to employ elderly by providing diversity of work forms.

  9. Synthesis and characterisation of new Schiff base monomers containing N-(alkyl and phenyl) pyrrole moieties (United States)

    Amer, Ahcene Ait; Ilikti, Hocine; Maschke, Ulrich


    This article deals with the synthesis and characterisation of seven new functional Schiff base monomers, such as: M1: 1-(3-Pyrrole-1-yl-propylimino-methyl)-naphtalen-2-ol; M2: 2-(3-Pyrrole-1-yl-phenylimino-methyl)-phenol; M3: 1-(3-Pyrrole-1-yl-phenylimino-methyl)-naphtalen-2-ol; M4: N-(pyridin-2-yl-methylene)-2-(pyrrol-1-yl)-benzenamine; M5: N-(pyridin-2-yl-methylene)-3-(pyrrol-1-yl)-propan-1-amine; M6: 2-(3-pyrrol-1-yl-propylimino-methyl)-quinolin-8-ol; M7: 2-(3-pyrrol-1-yl-phenylimino-methyl)-quinolin-8-ol. Two series of compounds emerged from this study, N-propyl pyrrole derivatives (M1, M5, M6) and N-phenyl pyrrole compounds (M2, M3, M4, M7). All monomers were elaborated by condensation reactions between appropriate amines and aldehydes, and their molecular structures were confirmed by spectroscopic analysis methods like FT-IR, 1H NMR, 13C NMR, and GC-MS.

  10. Effect of Antioxidant Mixtures on Growth and Ochratoxin A Production of Aspergillus Section Nigri Species under Different Water Activity Conditions on Peanut Meal Extract Agar

    Directory of Open Access Journals (Sweden)

    Carla Barberis


    Full Text Available The effect of mixtures of antioxidants butylated hydroxyanisol (BHA and propyl paraben (PP on lag phase, growth rate and ochratoxin A (OTA production by four Aspergillus section Nigri strains was evaluated on peanut meal extract agar (PMEA under different water activities (aw. The antioxidant mixtures used were: BHA + PP (mM, M1 (0.5 + 0.5, M2 (1.0 + 0.5, M3 (2.5 + 0.5, M4 (0.5 + 1.0, M5 (1.0 + 1.0, M6 (2.5 + 1.0, M7 (5.0 + 2.5 and M8 (10 + 2.5. The mixture M8 completely suppressed mycelial growth for all strains. A significant stimulation in OTA production was observed with mixtures M1 to M5 mainly at the highest aw; whereas M6, M7 and M8 completely inhibited OTA production in all strains assayed; except M6 in A. carbonarius strain (RCP G. These results could enable a future intervention strategy to minimize OTA contamination.

  11. Yield improvement of Kenyan sesame varieties

    International Nuclear Information System (INIS)

    Ayiecho, P.O.; Nyabundi, J.O.


    In an effort to improve the yield of Kenyan sesame cultivars the seeds of three cultivars, SPS SIK6, SIK 096 and SPS SIK 50/1 were subjected to 300Gy, 400Gy and 600Gy of gamma rays. A first batch of seeds were subjected to these treatments in March 1994 (Experiment I) while the second batch was treated in March 1995 (Experiment II). The M 1 , M 2 , M 3 and M 4 generations of experiment I and M 1 generation of Experiment II were raised at the University of Nairobi Dryland Research Field Station, Kibwezi from 1994 to 1996. The M 6 and M 7 generations of Experiment I and M 2 of Experiment II were raised at Siaya Farmer's Training Centre in 1997. The effects of radiation in M 1 generation were expressed in reduced and delayed seedling emergence, reduced plant height, sectorial deformed plants, delayed flowering and extremely low yield. There was increased variation in M 2 for most evaluated traits. Plants in M 2 and subsequent generations were scored for a number of yield related morphological traits and days to flowering. Selection was done in the early generations for increased capsule number and earliness. As a result of selection, a total of 88 lines from M 4 generation were used to derive M 5 generation. Further selection in M 6 generation lead to 35 lines being retained for preliminary yield trials in M 7 generations. (author)

  12. Westinghouse-GOTHIC modeling of NUPEC's hydrogen mixing and distribution test M-4-3

    International Nuclear Information System (INIS)

    Ofstun, R.P.; Woodcock, J.; Paulsen, D.L.


    NUPEC (NUclear Power Engineering Corporation) ran a series of hydrogen mixing and distribution tests which were completed in April 1992. These tests were performed in a 1/4 linearly scaled model containment and were specifically designed to be used for computer code validation. The results of test M-4-3, along with predictions from several computer codes, were presented to the participants of ISP-35 (a blind test comparison of code calculated results with data from NUPEC test M-7-1) at a meeting in March 1993. Test M-4-3, which was similar to test M-7-1, released a mixture of steam and helium into a steam generator compartment located on the lower level of containment. The majority of codes did well at predicting the global pressure and temperature trends, however, some typical lumped parameter modeling problems were identified at that time. In particular, the models had difficulty predicting the temperature and helium concentrations in the so called 'dead ended volumes' (pressurizer compartment and in-core chase region). Modeling of the dead-ended compartments using a single lumped parameter volume did not yield the appropriate temperature and helium response within that volume. The Westinghouse-GOTHIC (WGOTHIC) computer code is capable of modeling in one, two or three dimensions (or any combination thereof). This paper describes the WGOTHIC modeling of the dead-ended compartments for NUPEC test M-4-3 and gives comparisons to the test data. 1 ref., 1 tab., 14 figs

  13. The Consultancy Activity on In Silico Models for Genotoxic Prediction of Pharmaceutical Impurities. (United States)

    Pavan, Manuela; Kovarich, Simona; Bassan, Arianna; Broccardo, Lorenza; Yang, Chihae; Fioravanzo, Elena


    The toxicological assessment of DNA-reactive/mutagenic or clastogenic impurities plays an important role in the regulatory process for pharmaceuticals; in this context, in silico structure-based approaches are applied as primary tools for the evaluation of the mutagenic potential of the drug impurities. The general recommendations regarding such use of in silico methods are provided in the recent ICH M7 guideline stating that computational (in silico) toxicology assessment should be performed using two (Q)SAR prediction methodologies complementing each other: a statistical-based method and an expert rule-based method.Based on our consultant experience, we describe here a framework for in silico assessment of mutagenic potential of drug impurities. Two main applications of in silico methods are presented: (1) support and optimization of drug synthesis processes by providing early indication of potential genotoxic impurities and (2) regulatory evaluation of genotoxic potential of impurities in compliance with the ICH M7 guideline. Some critical case studies are also discussed.

  14. Effect of Cobalt on Microstructure and Wear Resistance of Ni-Based Alloy Coating Fabricated by Laser Cladding

    Directory of Open Access Journals (Sweden)

    Kaiming Wang


    Full Text Available Ni-based alloy powders with different contents of cobalt (Co have been deposited on a 42CrMo steel substrate surface using a fiber laser. The effects of Co content on the microstructure, composition, hardness, and wear properties of the claddings were studied by scanning electron microscopy (SEM, an electron probe microanalyzer (EPMA, X-ray diffraction (XRD, a hardness tester, and a wear tester. The results show that the phases in the cladding layers are mainly γ, M7(C, B3, M23(C, B6, and M2B. With the increase in Co content, the amounts of M7(C, B3, M23(C, B6, and M2B gradually decrease, and the width of the eutectic structure in the cladding layer also gradually decreases. The microhardness decreases but the wear resistance of the cladding layer gradually improves with the increase of Co content. The wear resistance of the NiCo30 cladding layer is 3.6 times that of the NiCo00 cladding layer. With the increase of Co content, the wear mechanism of the cladding layer is changed from abrasive wear to adhesive wear.

  15. Metabolic profiles of neratinib in rat by using ultra-high-performance liquid chromatography coupled with diode array detector and Q-Exactive Orbitrap tandem mass spectrometry. (United States)

    Liu, Wen; Li, Sha; Wu, Yangke; Yan, Xiao; Zhu, Y-M; Huang, J-H; Chen, Zhuo


    Neratinib is a tyrosine kinase inhibitor that has been approved by the US Food and Drug Administration for the treatment of breast cancer. However, its metabolism remains unknown. This study was carried out to investigate the in vitro and in vivo metabolism of neratinib using an UHPLC-DAD-Q Exactive Orbitrap-MS instrument with dd-MS 2 on-line data acquisition mode. The post-acquisition data was processed using MetWorks software. Under the current conditions, a total of 12 metabolites were detected and structurally identified based on their accurate masses, fragment ions and chromatographic retention times. Among these metabolites, M3, M10 and M12 were unambiguously identified using chemically synthesized reference standards. M6 and M7 (GSH conjugates) were the major metabolites. The metabolic pathways of neratinib were proposed accordingly. Our findings suggested that neratinib was mainly metabolized via O-dealkylation (M3), oxygenation (M8), N-demethylation (M10), N-oxygenation (M12), GSH conjugation (M1, M2, M4, M5, M6 and M7) and N-acetylcysteine conjugation (M9 and M11). The α,β-unsaturated ketone was the major metabolic site and GSH conjugation was the predominant metabolic pathway. In conclusion, this study provided valuable metabolic data and would benefit the assessment of the contributions to the overall activity or toxicity from the key metabolites. Copyright © 2018 John Wiley & Sons, Ltd.

  16. Effect of zirconium on the structure and phase composition of steel 03Kh8SYu

    International Nuclear Information System (INIS)

    Tarzhumanova, V.A.; Ryabchenkov, A.V.; Shatunova, A.V.; Yoganova, S.A.


    Previously, the authors determined the optimum zirconium content providing retention of a fine-grained structure for steel 03Kh8SYu during high-temperature heating. It was suggested that this was caused by separation in the steel of intermetallic phase Fe 3 Zr. This paper presents results of further studies in this direction. X-ray analysis results for the anodic residues of the steels are presented. It can be seen that in steel without zirconium, carbides of the type M 23 C 6 and M 7 C 3 and aluminum nitride are present. On adding 0.05% Zr, zirconium nitride forms in addition to the existing aluminum nitride and carbides of the type M 7 C 3 . The authors also investigated the effect of zirconium on the tendency of the steel toward grain growth at higher temperature; they studied the structure of steel 03Kh8SYu with 0.61% Zr after soaking specimens for 100 h at 950-1100 C. Results are presented

  17. Study of the Quantitative and Qualitative Traits of Four Soybean (Glycine max L. Cultivars under Different Sowing Dates in Shahrekord Region

    Directory of Open Access Journals (Sweden)

    H. Gharakhani Beni


    Full Text Available To study the effect of sowing date on quantitave and qualitative traits of soybean in Shahrekord region, an experiment was performed as split plot based on randomized complete blocks design with four replications at Agricultural and Natural Resources Research Centre of Chaharmahal-va-Bakhtiari, Shahrekord, in 2008. Four sowing dates (May 5, May 20, June 4 and June 19 and four varieties (M9, M7, L17 and Williams were selected as main and sub plots, respectively. Results showed that maximum number of pods per plant, seeds per plant and biological yield were observed for M9 cultivar at 20 May sowing date. This sowing date had also the highest seed weight, oil percent and biological yield comared to other dates. The maximum protein percent was observed in June 4 (37.6% and June 19 (38.4% sowing dates. There was no significant difference between cultivars for oil and protein percent. There was no significant difference between three planting dates of May 5, May 20 and June 4 for seed yield. But minimum seed yield belonged to June 19 sowing date. In general, the M9 cultivar, with 2896.1 kg/ha seed yield, and then M7 cultivar with 2597.7 kg/ha seed yield, are recommendable as suitable soybean cultivars for cultivation in Shahrekord region.

  18. Liquefaction Hazard Maps for Three Earthquake Scenarios for the Communities of San Jose, Campbell, Cupertino, Los Altos, Los Gatos, Milpitas, Mountain View, Palo Alto, Santa Clara, Saratoga, and Sunnyvale, Northern Santa Clara County, California (United States)

    Holzer, Thomas L.; Noce, Thomas E.; Bennett, Michael J.


    Maps showing the probability of surface manifestations of liquefaction in the northern Santa Clara Valley were prepared with liquefaction probability curves. The area includes the communities of San Jose, Campbell, Cupertino, Los Altos, Los Gatos Milpitas, Mountain View, Palo Alto, Santa Clara, Saratoga, and Sunnyvale. The probability curves were based on complementary cumulative frequency distributions of the liquefaction potential index (LPI) for surficial geologic units in the study area. LPI values were computed with extensive cone penetration test soundings. Maps were developed for three earthquake scenarios, an M7.8 on the San Andreas Fault comparable to the 1906 event, an M6.7 on the Hayward Fault comparable to the 1868 event, and an M6.9 on the Calaveras Fault. Ground motions were estimated with the Boore and Atkinson (2008) attenuation relation. Liquefaction is predicted for all three events in young Holocene levee deposits along the major creeks. Liquefaction probabilities are highest for the M7.8 earthquake, ranging from 0.33 to 0.37 if a 1.5-m deep water table is assumed, and 0.10 to 0.14 if a 5-m deep water table is assumed. Liquefaction probabilities of the other surficial geologic units are less than 0.05. Probabilities for the scenario earthquakes are generally consistent with observations during historical earthquakes.

  19. Microstructural evolution in austenitic heat-resistant cast steel 35Cr25Ni12NNbRE during long-term service

    International Nuclear Information System (INIS)

    Liu Jiangwen; Jiao Dongling; Luo Chengping


    The microstructural evolution of austenitic heat-resistant cast steel 35Cr25Ni12NNbRE during aging and long-term service was investigated using optical microscope (OM), X-ray diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscope (TEM). The microstructure of the as cast steel consists of the dendritic austenite, the block-like eutectic carbide M 7 C 3 spreaded among austenitic dendrite, and a small quantity of M 23 C 6 carbide. The microstructure of the steel aged at 600 deg. C consists of eutectic carbide M 23 C 6 transformed from eutectic carbide M 7 C 3 and dendritic austenite in which fine secondary carbide particles M 23 C 6 precipitated. The precipitated carbide M 23 C 6 kept a cubic-cubic orientation relationship (OR) with austenite matrix. There existed a carbide precipitation free zone (PFZ) around the eutectic carbide. For the long-term serviced samples, the secondary carbide precipitated in the austenite strikingly increased and the PFZ disappeared. Part of the M 23 C 6 transformed into M 6 C, which always kept a twin OR, [114] M 6 C //[110] A //[110] M 23 C 6 , with the austenite and the M 23 C 6 secondary carbide. In addition, a small quantity of σ phase FeCr and ε-Cr 2 N were also identified. The effects of alloy composition and service condition on the microstructural evolution of the steel were discussed.

  20. A comparison of fatigue crack growth in human enamel and hydroxyapatite. (United States)

    Bajaj, Devendra; Nazari, Ahmad; Eidelman, Naomi; Arola, Dwayne D


    Cracks and craze lines are often observed in the enamel of human teeth, but they rarely cause tooth fracture. The present study evaluates fatigue crack growth in human enamel, and compares that to the fatigue response of sintered hydroxyapatite (HAp) with similar crystallinity, chemistry and density. Miniature inset compact tension (CT) specimens were prepared that embodied a small piece of enamel (N=8) or HAp (N=6). The specimens were subjected to mode I cyclic loads and the steady state crack growth responses were modeled using the Paris Law. Results showed that the fatigue crack growth exponent (m) for enamel (m=7.7+/-1.0) was similar to that for HAp (m=7.9+/-1.4), whereas the crack growth coefficient (C) for enamel (C=8.7 E-04 (mm/cycle)x(MPa m(0.5))(-m)) was significantly lower (pcrack growth in the enamel occurred primarily along the prism boundaries. In regions of decussation, the microstructure promoted microcracking, crack bridging, crack deflection and crack bifurcation. Working in concert, these mechanisms increased the crack growth resistance and resulted in a sensitivity to crack growth (m) similar to bone and lower than that of human dentin. These mechanisms of toughening were not observed in the crack growth response of the sintered HAp. While enamel is the most highly mineralized tissue of the human body, the microstructural arrangement of the prisms promotes exceptional resistance to crack growth.

  1. Assesment of spineless safflower (Carthamus tinctorius, L.) mutant lines for seed oil content and fatty acid profiles

    International Nuclear Information System (INIS)

    Ragab, A.I.; Kassem, M.; Moustafa, H.A.M.


    This study was conducted to assess the new spineless mutants that previously induced through gamma radiation and hybridization techniques in the advanced generation for seed oil content and fatty acid profiles The obtained results cleared that oil percentages of all seven safflower mutants were increased than local variety Giza (1) and the new mutant hybrid 2 line (white petals) had the highest increase value of oil percentage (10%) but the mutant line M14 (dark red petals) had the lowest increase value of oil percentage (3.1 %) The mutant line M7 (yellow petals) had the highest value of total saturated fatty acid (40.38%), because it had the highest value of palmitic fatty acid (25.16%), comparing to 10.01% value for local variety Giza (1), followed by mutant line hybrid 2 (white petals) which had (39.88%) because it had the highest value of caprylic, capric, lauric, myristic and stearic fatty acids. All safflower mutant lines had higher value of oleic fatty acid than that of the local variety Giza (1) the two new safflower mutant lines M7 (yellow petals) and hybrid 2 (white petal) had the highest value of oleic fatty acid 41.22% and 39.88% respectively in comparison with 13.5% for local variety Giza (1), the obtained results are indicating to seed oil content negative correlation between oleic and linoleic acids

  2. Herbicidal and antioxidant responses of transgenic rice overexpressing Myxococcus xanthus protoporphyrinogen oxidase. (United States)

    Jung, Sunyo; Back, Kyoungwhan


    We analyzed the herbicidal and antioxidant defense responses of transgenic rice plants that overexpressed the Myxococcus xanthus protoporphyrinogen oxidase gene. Leaf squares of the wild-type incubated with oxyfluorfen were characterized by necrotic leaf lesions and increases in conductivity and malonyldialdehyde levels, whereas transgenic lines M4 and M7 did not show any change with up to 100 microM oxyfluorfen. The wild-type had decreased F(v)/F(m) and produced a high level of H(2)O(2) at 18 h after foliar application of oxyfluorfen, whereas transgenic lines M4 and M7 were unaffected. In response to oxyfluorfen, violaxanthin, beta-carotene, and chlorophylls (Chls) decreased in wild-type plants, whereas antheraxanthin and zeaxanthin increased. Only a slight decline in Chls was observed in transgenic lines at 48 h after oxyfluorfen treatment. Noticeable increases of cytosolic Cu/Zn-superoxide dismutase, peroxidase isozymes 1 and 2, and catalase were observed after at 48 h of oxyfluorfen treatment in the wild-type. Non-enzymatic antioxidants appeared to respond faster to oxyfluorfen-induced photodynamic stress than did enzymatic antioxidants. Protective responses for the detoxification of active oxygen species were induced to counteract photodynamic stress in oxyfluorfen-treated, wild-type plants. However, oxyfluorfen-treated, transgenic plants suffered less oxidative stress, confirming increased herbicidal resistance resulted from dual expression of M. xanthus Protox in chloroplasts and mitochondria.

  3. Gauged supergravities from M-theory reductions (United States)

    Katmadas, Stefanos; Tomasiello, Alessandro


    In supergravity compactifications, there is in general no clear prescription on how to select a finite-dimensional family of metrics on the internal space, and a family of forms on which to expand the various potentials, such that the lower-dimensional effective theory is supersymmetric. We propose a finite-dimensional family of deformations for regular Sasaki-Einstein seven-manifolds M 7, relevant for M-theory compactifications down to four dimensions. It consists of integrable Cauchy-Riemann structures, corresponding to complex deformations of the Calabi-Yau cone M 8 over M 7. The non-harmonic forms we propose are the ones contained in one of the Kohn-Rossi cohomology groups, which is finite-dimensional and naturally controls the deformations of Cauchy-Riemann structures. The same family of deformations can be also described in terms of twisted cohomology of the base M 6, or in terms of Milnor cycles arising in deformations of M 8. Using existing results on SU(3) structure compactifications, we briefly discuss the reduction of M-theory on our class of deformed Sasaki-Einstein manifolds to four-dimensional gauged supergravity.

  4. Co- and postseismic slip distribution for the 2011 March 9 earthquake based on the geodetic data: Role on the initiation of the 2011 Tohoku earthquake (United States)

    Ohta, Y.; Hino, R.; Inazu, D.; Ohzono, M.; Mishina, M.; Nakajima, J.; Ito, Y.; Sato, T.; Tamura, Y.; Fujimoto, H.; Tachibana, K.; Demachi, T.; Osada, Y.; Shinohara, M.; Miura, S.


    A large foreshock with M7.3 occurred on March 9, 2011 at the subducting Pacific plate interface followed by the M9.0 Tohoku earthquake 51 hours later. We propose a slip distribution of the foreshock deduced from dense inland GPS sites and Ocean Bottom Pressure gauge (OBP) sites. The multiple OBP gauges were installed before the M7.3 foreshock in and around the focal area. We succeed to collect the OBP gauge data in 9 sites, which included two cabled OBPs in off Kamaishi (TM1, TM2). The inland GPS horizontal coseismic displacements are estimated based on baseline analyses to show the broad area of displacement field up to ~30mm directing to the focal area. In contrast, there is no coherent signal in the vertical components. The several OBP sites, for example, P2 and P6 sites located the westward from the epicenter of the foreshock clearly detected the coseismic displacement. The estimated coseismic displacement reached more than 100mm in P6 sites. Intriguingly, GJT3 sites, which the most nearly OBP sites from the epicenter, did not show the significant displacement. Based on the inland GPS sites and OBPs data, we estimated a coseismic slip distribution in the subducting plate interface. The estimated slip distribution can explain observations including the vertical displacement obtained at the OBP sites. The amount of moment release is equivalent to Mw 7.2. The spatio-temporal aftershock distribution of the foreshock shows a southward migration from our estimated fault model. We suggest that aseismic slip occurred after the M7.3 earthquake. The onshore GPS data also supports the occurrence of the afterslip in the southwestward area of the coseismic fault. We estimated the sub-daily coordinates every three hours at the several coastal GPS sites to reveal the time evolutional sequences suggesting the postseismic deformation, especially in the horizontal components. We also examine volumetric strain data at Kinka-san Island, which is situated at the closest distance

  5. Kinetics of high-Level of ß-glucosidase production by a 2-deoxyglucose-resistant mutant of Humicola lanuginosa in submerged fermentation Cinética de produção de ß-glucosidase por um mutante de Hemicola lanuginosa resistente a 2-deoxiglucose em fermentação submersa

    Directory of Open Access Journals (Sweden)

    Syed Ali Imran Bokhari


    Full Text Available A 2-deoxyglucose-resistant mutant (M7 of Humicola lanuginosa was obtained by exposing conidia to γ-rays and permitting expression in broth containing 0.6% 2-deoxyglucose (DG and cellobiose (1% before plating on DG esculin-ferric ammonium citrate agar medium from which colonies showing faster and bigger blackening zones were selected. Kinetic parameters for enhanced ß-glucosidase (BGL synthesis by M7 were achieved when corncobs acted as the carbon source. The combination between corncobs and corn steep liquor was the best to support higher values of all product formation kinetic parameters. Effect of temperature on the kinetic and thermodynamic attributes of BGL production equilibrium in the wild organismand M7was studied using batch process at eight different temperatures in shake-flask studies. The best performance was found at 45ºC and 20 g L-1 corncobs in 64 h. Both growth and product formation (17.93 U mL-1 were remarkably high at 45ºC and both were coupled under optimum working conditions. Product yield of BGL from the mutant M7 (1556.5 U g-1 dry corncobs was significantly higher than the values reported on all fungal and bacterial systems. Mutation had thermo-stabilization influence on the organism and mutant required lower activation energy for growth and lower magnitudes of enthalpy and entropy for product formation than those demanded by the wild organism, other mesophilic and thermo-tolerant organisms. In the inactivation phase, the organisms needed lower values of activation energy, enthalpy and entropy for product formation equilibrium, confirming thermophilic nature of metabolic network possessed by the mutant organism.Um mutante de Hemicola lanuginosa resistente a 2-deoxiglucose(M7 foi obtido através de exposição de conídios a raios γ, permitindo a expressão em caldo contendo 0,6% de 2-deoxiglucose (DG e celobiose (1% antes da semeadura em ágar DG esculina citrato de ferro amoniacal, da qual foram selecionadas as col

  6. Validation of Atmosphere/Ionosphere Signals Associated with Major Earthquakes by Multi-Instrument Space-Borne and Ground Observations (United States)

    Ouzounov, Dimitar; Pulinets, Sergey; Hattori, Katsumi; Parrot, Michel; Liu, J. Y.; Yang, T. F.; Arellano-Baeza, Alonso; Kafatos, M.; Taylor, Patrick


    regions of the atmosphere and the modifications, by dc electric fields, in the ionosphere-atmosphere electric circuit. We retrospectively analyzed temporal and spatial variations of four different physical parameters (gas/radon counting rate, lineaments change, long-wave radiation transitions and ionospheric electron density/plasma variations) characterizing the state of the lithosphere/atmosphere coupling several days before the onset of the earthquakes. Validation processes consist in two phases: A. Case studies for seven recent major earthquakes: Japan (M9.0, 2011), China (M7.9, 2008), Italy (M6.3, 2009), Samoa (M7, 2009), Haiti (M7.0, 2010) and, Chile (M8.8, 2010) and B. A continuous retrospective analysis was preformed over two different regions with high seismicity- Taiwan and Japan for 2003-2009. Satellite, ground surface, and troposphere data were obtained from Terra/ASTER, Aqua/AIRS, POES and ionospheric variations from DEMETER and COSMIC-I data. Radon and GPS/TEC were obtaining from monitoring sites in Taiwan, Japan and Italy and from global ionosphere maps (GIM) respectively. Our analysis of ground and satellite data during the occurrence of 7 global earthquakes has shown the presence of anomalies in the atmosphere. Our results for Tohoku M9.0 earthquake show that on March 7th, 2011 (4 days before the main shock and 1 day before the M7.2 foreshock of March 8, 2011) a rapid increase of emitted infrared radiation was observed by the satellite data and an anomaly was developed near the epicenter. The GPS/TEC data indicate an increase and variation in electron density reaching a maximum value on March 8. From March 3 to 11 a large increase in electron concentration was recorded at all four Japanese ground-based ionosondes, which returned to normal after the main earthquake. Similar approach for analyzing atmospheric and ionospheric parameters has been applied for China (M7.9, 2008), Italy (M6.3, 2009), Samoa (M7, 2009), Haiti (M7.0, 2010) and Chile (M8.8, 2010

  7. Geodetic characteristic of the postseismic deformation following the interplate large earthquake along the Japan Trench (Invited) (United States)

    Ohta, Y.; Hino, R.; Ariyoshi, K.; Matsuzawa, T.; Mishina, M.; Sato, T.; Inazu, D.; Ito, Y.; Tachibana, K.; Demachi, T.; Miura, S.


    On March 9, 2011 at 2:45 (UTC), an M7.3 interplate earthquake (hereafter foreshock) occurred ~45 km northeast of the epicenter of the M9.0 2011 Tohoku earthquake. This foreshock preceded the 2011 Tohoku earthquake by 51 hours. Ohta et al., (2012, GRL) estimated co- and postseismic afterslip distribution based on a dense GPS network and ocean bottom pressure gauge sites. They found the afterslip distribution was mainly concentrated in the up-dip extension of the coseismic slip. The coseismic slip and afterslip distribution of the foreshock were also located in the slip deficit region (between 20-40m slip) of the coiseismic slip of the M9.0 mainshock. The slip amount for the afterslip is roughly consistent with that determined by repeating earthquake analysis carried out in a previous study (Kato et al., 2012, Science). The estimated moment release for the afterslip reached magnitude 6.8, even within a short time period of 51 hours. They also pointed out that a volumetric strainmeter time series suggests that this event advanced with a rapid decay time constant (4.8 h) compared with other typical large earthquakes. The decay time constant of the afterslip may reflect the frictional property of the plate interface, especially effective normal stress controlled by fluid. For verification of the short decay time constant of the foreshock, we investigated the postseismic deformation characteristic following the 1989 and 1992 Sanriku-Oki earthquakes (M7.1 and M6.9), 2003 and 2005 Miyagi-Oki earthquakes (M6.8 and M7.2), and 2008 Fukushima-Oki earthquake (M6.9). We used four components extensometer at Miyako (39.59N, 141.98E) on the Sanriku coast for 1989 and 1992 event. For 2003, 2005 and 2008 events, we used volumetric strainmeter at Kinka-zan (38.27N, 141.58E) and Enoshima (38.27N, 141.60E). To extract the characteristics of the postseismic deformation, we fitted the logarithmic function. The estimated decay time constants for each earthquake had almost similar range (1

  8. Coulomb stress transfer and tectonic loading preceding the 2002 Denali fault earthquake (United States)

    Bufe, Charles G.


    Pre-2002 tectonic loading and Coulomb stress transfer are modeled along the rupture zone of the M 7.9 Denali fault earthquake (DFE) and on adjacent segments of the right-lateral Denali–Totschunda fault system in central Alaska, using a three-dimensional boundary-element program. The segments modeled closely follow, for about 95°, the arc of a circle of radius 375 km centered on an inferred asperity near the northeastern end of the intersection of the Patton Bay fault with the Alaskan megathrust under Prince William Sound. The loading model includes slip of 6 mm/yr below 12 km along the fault system, consistent with rotation of the Wrangell block about the asperity at a rate of about 1°/m.y. as well as slip of the Pacific plate at 5 cm/yr at depth along the Fairweather–Queen Charlotte transform fault system and on the Alaska megathrust. The model is consistent with most available pre-2002 Global Positioning System (GPS) displacement rate data. Coulomb stresses induced on the Denali–Totschunda fault system (locked above 12 km) by slip at depth and by transfer from the M 9.2 Prince William Sound earthquake of 1964 dominated the changing Coulomb stress distribution along the fault. The combination of loading (∼70–85%) and coseismic stress transfer from the great 1964 earthquake (∼15–30%) were the principal post-1900 stress factors building toward strike-slip failure of the northern Denali and Totschunda segments in the M 7.9 earthquake of November 2002. Postseismic stresses transferred from the 1964 earthquake may also have been a significant factor. The M 7.2–7.4 Delta River earthquake of 1912 (Carver et al., 2004) may have delayed or advanced the timing of the DFE, depending on the details and location of its rupture. The initial subevent of the 2002 DFE earthquake was on the 40-km Susitna Glacier thrust fault at the western end of the Denali fault rupture. The Coulomb stress transferred from the 1964 earthquake moved the Susitna Glacier thrust

  9. Evaluation of Yield and Chemical Characteristics of some Peanut Mutants Induced by Gamma Irradiation

    International Nuclear Information System (INIS)

    Abd El-daem, G.A.; Anwar, M.M.


    This study was conducted to evaluate some promising mutants in peanut for yielding ability over three generation (M5, M6 and M7) and to evaluate yield attributes as will as chemical characteristics of these mutants in M7 generation induced by 100 Gy gamma radiation. The obtained results showed that the increase of yield / plot over three generation as a percentage of control was 5% for mutant 7, 10.2 % for mutant 10; 22% for mutant 9 and 22.9% for mutant 8. This increase in yield may be due to increase of one or more of yield attributes for most mutant lines. The significant increase for. No .of pods and seeds/ plant, weight of pods and seeds/ plant and 100- seed weight in M7 as compared to the control. For saturated fatty acid composition, results revealed that total saturated fatty acids ranged from 17.79% for mutant 8 to 21.75 for mutant 2 compared to 24.21% for control. Reduction of total saturated fatty acid was noticed for different mutants compared to that of the original variety. However, for total unsaturated fatty acids, results indicated that total unsaturated fatty acid composition ranged from 77.95% for mutant 9 to 82.09% for mutant 8 compared to 75.49% for control. Higher total unsaturated fatty acids for all mutant lines were obtained than that of the control, however, total saturated (TS)/ total unsaturated (TU) ratio was decreased for all mutants compared to control. The physical and chemical contents of Peanut oils showed that the refractive indices were ranged from 1.4620 to 1.4718 specific gravity were in range of 0.9146 to 0.9177. Acid value was range from 0.54 to 0.89% lodine value was ranged from 94.56 to 101.85. Saponification value was ranged from 185.2 to 190.7 and unsaponifiable matter was ranged from 0.98 to 1.33. The peroxide values ranged from 1.15 to 2.33 meq/kg oil. Also, fortified yoghurt made with replaced mutant peanut oil by 50% as milk fat substitute. Data showed that chemical composition and organolyptic properties had the


    International Nuclear Information System (INIS)

    McLean, M.; Berger, E.; Reiners, A.


    We present a new radio survey of about 100 late-M and L dwarfs undertaken with the Very Large Array. The sample was chosen to explore the role of rotation in the radio activity of ultracool dwarfs. As part of the survey we discovered radio emission from three new objects, 2MASS J 0518113 – 310153 (M6.5), 2MASS J 0952219 – 192431 (M7), and 2MASS J 1314203 + 132001 (M7), and made an additional detection of LP 349-25 (M8). Combining the new sample with results from our previous studies and from the literature, we compile the largest sample to date of ultracool dwarfs with radio observations and measured rotation velocities (167 objects). In the spectral type range M0-M6 we find a radio activity-rotation relation, with saturation at L rad /L bol ≈ 10 –7.5 above vsin i ≈ 5 km s –1 , similar to the relation in Hα and X-rays. However, at spectral types ∼> M7 the ratio of radio to bolometric luminosity increases significantly regardless of rotation velocity, and the scatter in radio luminosity increases. In particular, while the most rapid rotators (vsin i ∼> 20 km s –1 ) exhibit 'super-saturation' in X-rays and Hα, this effect is not seen in the radio. We also find that ultracool dwarfs with vsin i ∼> 20 km s –1 have a higher radio detection fraction by about a factor of three compared to objects with vsin i ∼ –1 . When measured in terms of the Rossby number (Ro), the radio activity-rotation relation follows a single trend and with no apparent saturation from G to L dwarfs and down to Ro ∼ 10 –3 ; in X-rays and Hα there is clear saturation at Ro ∼ rad /R 2 * ) as a function of Ro. The continued role of rotation in the overall level of radio activity and in the fraction of active sources, and the single trend of L rad /L bol and L rad /R 2 * as a function of Ro from G to L dwarfs, indicates that rotation effects are important in regulating the topology or strength of magnetic fields in at least some fully convective dwarfs. The fact that

  11. Comparison of the November 2002 Denali and November 2001 Kunlun Earthquakes (United States)

    Bufe, C. G.


    Major earthquakes occurred in Tibet on the central Kunlun fault (M 7.8) on November 14, 2001 (Lin and others, 2002) and in Alaska on the central Denali fault (M 7.9) on November 3, 2002. Both earthquakes generated large surface waves (Kunlun Ms 8.0 (USGS) and Denali Ms 8.5). Each event occurred on east-west-trending strike-slip faults and exhibited nearly unilateral rupture propagating several hundred kilometers from west to east. Surface rupture length estimates were about 400 km for Kunlun, 300 km for Denali. Maximum surface faulting and moment release were observed far to the east of the points of rupture initiation. Harvard moment centroids were located east of USGS epicenters by 182 km (Kunlun) and by 126 km (Denali). Maximum surface faulting was observed near 240 km (Kunlun, 16 m left lateral) and near 175 km (Denali, 9 m right lateral) east of the USGS epicenters. Significant thrust components were observed in the initiation of the Denali event (ERI analysis and mapped thrust) and in the termination of the Kunlun rupture, as evidenced by thrust mechanisms of the largest aftershocks which occurred near the eastern part of the Kunlun rupture. In each sequence the largest aftershock was about 2 orders of magnitude smaller than the mainshock. Moment release along the ruptured segments was examined for the 25-year periods preceding the main shocks. The Denali zone shows precursory accelerating moment release with the dominant events occurring on October 22, 1996 (M 5.8) and October 23, 2002 (M 6.7). The Kunlun zone shows nearly constant moment release over time with the last significant event before the main shock occurring on November 26, 2000 (M 5.4). Moment release data are consistent with previous observations of annual periodicity preceding major earthquakes, possibly due to the evolution of a critical state with seasonal and tidal triggering (Varnes and Bufe, 2001). Annual periodicity is also evident for the larger events in the greater San Francisco Bay

  12. FGF-2 expression and the amount of fibroblast in the incised wounds of Rattus norvegicus rats induced with Mauli banana (Musa acuminata stem extract

    Directory of Open Access Journals (Sweden)

    Didit Aspriyanto


    Full Text Available Background: Traditional wound treatment using herbal medicine is thought to maintain the health of families and society in general economically, effectively, and efficiently without inducing side effects. One genus of plant that can be used as a traditional medicine is the Mauli banana, indigenous to South Borneo. Mauli banana stem contains bioactive compounds, most of which are tannins along with ascorbic acid, saponin, β-carotene, flavonoids, lycopene, alkaloids, and flavonoids. Tanin has antibacterial and antioxidant effects at low concentrations, as wells as antifungal ones at high concentrations. Purpose: This study aimed to analyze the effects of Mauli banana stem extract at concentrations of 25%, 37.5%, and 50% on the quality of incised wound healing in male Rattus norvegicus rats by assessing FGF-2 expression and fibroblast concentration on days 3 and 7. Methods: This research represented an experimental laboratory-based investigation involving 32 rats of the Rattus norvegicus strain aged 2-2.5 months old. Sampling was performed using a simple random sampling technique since the research population was considered homogeneous and divided into 8 treatment groups (C3, M3-25, M3-37.5, M3-50, C7, M7-25, M7-37.5, M7-50. The rats in each group were anesthetized before their back was incised with length and width of 15x15mm with a depth of 2mm. Gel hydroxy propyl cellulose medium (HPMC was applied to the incised wound of each rat in the control group, while stem Mauli banana extract was applied to that of each rat in the treatment groups three times a day at an interval of 6-8 hours. On day 3, four rats from each group were sacrificed, while, in the remaining groups, the same procedure was performed until day 7, at which point they (8 groups were sacrificed for HE examination in order to assess the amount of fibroblast and for IHC examination to examine FGF-2 expression. Data regarding FGF-2 expression and the amount of fibroblast were analysed

  13. Illumina MiSeq Phylogenetic Amplicon Sequencing Shows a Large Reduction of an Uncharacterised Succinivibrionaceae and an Increase of the Methanobrevibacter gottschalkii Clade in Feed Restricted Cattle.

    Directory of Open Access Journals (Sweden)

    Matthew Sean McCabe

    Full Text Available Periodic feed restriction is used in cattle production to reduce feed costs. When normal feed levels are resumed, cattle catch up to a normal weight by an acceleration of normal growth rate, known as compensatory growth, which is not yet fully understood. Illumina Miseq Phylogenetic marker amplicon sequencing of DNA extracted from rumen contents of 55 bulls showed that restriction of feed (70% concentrate, 30% grass silage for 125 days, to levels that caused a 60% reduction of growth rate, resulted in a large increase of relative abundance of Methanobrevibacter gottschalkii clade (designated as OTU-M7, and a large reduction of an uncharacterised Succinivibrionaceae species (designated as OTU-S3004. There was a strong negative Spearman correlation (ρ = -0.72, P = <1x10(-20 between relative abundances of OTU-3004 and OTU-M7 in the liquid rumen fraction. There was also a significant increase in acetate:propionate ratio (A:P in feed restricted animals that showed a negative Spearman correlation (ρ = -0.69, P = <1x10(-20 with the relative abundance of OTU-S3004 in the rumen liquid fraction but not the solid fraction, and a strong positive Spearman correlation with OTU-M7 in the rumen liquid (ρ = 0.74, P = <1x10(-20 and solid (ρ = 0.69, P = <1x10(-20 fractions. Reduced A:P ratios in the rumen are associated with increased feed efficiency and reduced production of methane which has a global warming potential (GWP 100 years of 28. Succinivibrionaceae growth in the rumen was previously suggested to reduce methane emissions as some members of this family utilise hydrogen, which is also utilised by methanogens for methanogenesis, to generate succinate which is converted to propionate. Relative abundance of OTU-S3004 showed a positive Spearman correlation with propionate (ρ = 0.41, P = <0.01 but not acetate in the liquid rumen fraction.

  14. Synthetic strong ground motions for engineering design utilizing empirical Green`s functions

    Energy Technology Data Exchange (ETDEWEB)

    Hutchings, L.J.; Jarpe, S.P.; Kasameyer, P.W.; Foxall, W.


    We present a methodology for developing realistic synthetic strong ground motions for specific sites from specific earthquakes. We analyzed the possible ground motion resulting from a M = 7.25 earthquake that ruptures 82 km of the Hayward fault for a site 1.4 km from the fault in the eastern San Francisco Bay area. We developed a suite of 100 rupture scenarios for the Hayward fault earthquake and computed the corresponding strong ground motion time histories. We synthesized strong ground motion with physics-based solutions of earthquake rupture and applied physical bounds on rupture parameters. By having a suite of rupture scenarios of hazardous earthquakes for a fixed magnitude and identifying the hazard to the site from the statistical distribution of engineering parameters, we introduce a probabilistic component into the deterministic hazard calculation. Engineering parameters of synthesized ground motions agree with those recorded from the 1995 Kobe, Japan and the 1992 Landers, California earthquakes at similar distances and site geologies.

  15. Activities report of Instituto de Engenharia Nuclear - 1993

    International Nuclear Information System (INIS)


    This is an activities report of 1993 year from Nuclear Engineering Institute - IEN, Brazilian CNEN. It achieves research and development in science and technology in nuclear areas and correlative, generating knowledge, products and services in society benefit. Its major activities are: production and supply of 30 equipment for radioprotection and nuclear physics, and the project and construction of monitoring system of neutron flux and radioprotection of Triga reactor of CDTN; project and construction of an actuation/attenuation circuit system of ATWS (anticipated transient without scram) at Angra-1 nuclear power plant; obtention of rare earths; development and optimization of a computational program to three-dimensional fluid mechanic - NSD 3D; study of technical and economical feasibility to the implantation, at IEN, of a big size irradiator for the sterilization, using ionizing radiation, of hospital, pharmaceutical and cosmetic goods. (C.M.). 7 tabs, 2 graphs

  16. Enhanced Enzymatic Production of Cephalexin at High Substrate Concentration with in situ Product Removal by Complexation

    Directory of Open Access Journals (Sweden)

    Dengchao Li


    Full Text Available Cephalexin (CEX was synthesized with 7-amino-3-deacetoxycephalosporanic acid (7-ADCA and D(–-phenylglycine methyl ester (PGME using immobilized penicillin G acylase from Escherichia coli. It was found that substrate concentration and in situ product could remarkably influence the ratio of synthesis to hydrolysis (S/H and the efficiency of CEX synthesis. The optimal ratio of enzyme to substrate was 65 IU/mM 7-ADCA. High substrate concentration improved the 7-ADCA conversion from 61 to 81 % in the process without in situ product removal (ISPR, while in the synthetic process with ISPR, high substrate concentration increased the 7-ADCA conversion from 88 to 98 %. CEX was easily separated from CEX/β-naphthol complex and its purity and overall yield were 99 and 70 %, respectively.

  17. Estimating a Seismic Station’s Detection Capability from Noise. Application to VLPE Stations (United States)


    SFTSIOMKTFP OMTPir nn Y M fl R Y HIP f’^S P^P/ LOT ion Lo; AMP Rliq AMP PUS PATTO PFP 1 IP. 107 I?1,67 1«,^ 1 1. r. 1 2.00 1.P2 1,0« 2P 7. 1...ion AIP RIS Air PIS PATTO ppp \\u 71 7 (1 ^ . Tl S.SII H, 1U l.f s 0.7a n.01 2fl m 7^ If 󈧳.7» ^.I’l 7.^M 1 .^fl 0.70 0.00 ?n if 73 1 1 IW. 1 s.ns...1.01 0.0« 0%11 ATI, PATTO AVP LOfi VAI/IF" «IP iTTHI« (^FAN »rp- 7 ♦’■T P. P’-V . 1 E-7 J mmmmmm ■■ TABLE E-6

  18. A study of sensitivity and specificity of CD64 expression in acute myeloid leukemia

    International Nuclear Information System (INIS)

    Jin Haijie; Gao Xiaoning; Chen Weihua; Li Meng; Sun Jingfen; Han Xiaopin; Yu Li


    To study the sensitivity and specificity of CD64 in immunotyping of acute myeloid leukemia(AML). The bone marrow cells from 132 patients with AML were labelled with a series of antigens and were analyzed by flow cytometry. CD64 has high sensitivity in patients with acute myelomonocytic leukemia (M4) 96.4% and acute monocytic leukemia (MS) (96.4% and 100%, respectively). The expressions of CD64 was very low on patients with other kinds of AML(M0, M1, M2, M3, M6, M7). The specificity of CD64 in patients with M4 and M5 was 56.5%. The results suggest that the CD64 is helpful in the differential diagnosis of M4 and M5 in AML patients. (authors)

  19. Antibacterial activity of oregano and sage plant extracts against decarboxylase-positive enterococci isolated from rabbit meat

    Directory of Open Access Journals (Sweden)

    Ľubica Chrastinová


    Full Text Available The effect of plant extracts (sage, oregano against decarboxylase-positive enterococci from rabbit back limb meat  was reported in this study. Oregano plant extract inhibited the growth of all 34 tested enterococci (the inhibitory zones: 12 to 45 mm. The growth of the majority of strains  (n=23 was inhibited by oregano plant extract (the high size inhibitory zones (higher than 25 mm. The growth of 11 strains  was inhibited by oregano extract reaching medium size inhibitory zones (10 to 25mm. The most sensitive strain to oregano extract was E. faecium M7bA (45 mm. Sage extract was less active against tested enterococci (n=16  reaching lower inhibitory zones (up to 10 mm. doi:10.5219/239 Normal 0 21 false false false SK X-NONE X-NONE

  20. A New Method for Global Optimization Based on Stochastic Differential Equations. (United States)


    Serie Naranja, n. 204, IINAS-UNAM, Mx ic o D. F. , 1979. [6] A. V. Levy, A. Montalvo, S. G6mez, A. Cald’er6n, ’Topics in global optimi~zation", in: J...FTFOPT aF 455. £ 456. C S7ART SERIES OF TR IAL5 457. C 458. DO 30 IC x 1,M7RIA&. 459. C 46r’. C SET INITIALIZATION IN&EX FOR NOISE GENERATOR 461. C 1 462...Ia iunghezza del passo di integrazione temporale , t k =o+ hi+ h 2+ ... + h kl rk e u ksono due vettori aleatori in n.-dimensioni scelti ii primo da

  1. Avaliação clínica de cães submetidos à parada circulatória total por diferentes períodos de tempo através da técnica de "Inflow Occlusion" Clinical evaluation of dogs submitted to circulatory arrest for different periods of time by "Inflow Occlusion"

    Directory of Open Access Journals (Sweden)

    Daniel C. Garcia


    Full Text Available A técnica de "Inflow Occlusion" pode ser utilizada em cirurgias cardíacas quando se pretende manter o coração aberto apenas por alguns minutos, para realização de pequenos reparos. No entanto, a parada circulatória total (PCT, evento decorrente da técnica em questão, pode acarretar severas alterações metabólicas e neurológicas ao paciente. Neste estudo foram utilizados 12 cães sem raça definida, os quais foram divididos em dois grupos, A e B, sendo os mesmos submetidos a 7 e 8 minutos de PCT, respectivamente, utilizando-se da técnica de "Inflow Occlusion". Tentou-se estabelecer normotermia durante os procedimentos cirúrgicos. Avaliações clínica e comportamental foram realizadas nos dois grupos após os procedimentos cirúrgicos e dados bioquímicos foram coletados para comparação entre os períodos pré e pós-operatórios. Ocorreram dois óbitos transoperatórios no grupo B. Alterações clínicas transitórias foram observadas no grupo A até o momento M7 (48 horas após cirurgia, e no grupo B, as mesmas foram mais intensas e presentes mesmo após M7; e em um animal do grupo B foi observada cegueira permanente por todo o período de acompanhamento. Apesar das alterações observadas, há indícios que seja seguro realizar a técnica de "Inflow Occlusion" por até 7 minutos, sendo contra-indicada, no entanto, para períodos mais prolongados."Inflow Occlusion" technique can be used in heart surgeries when heart is required to be opened just for few minutes, to allow quick repairs. However, circulatory arrest, event occasioned by this technique, may produce serious metabolic and neurological consequences to the patient. In this study, 12 mongrel dogs were used, divided into two groups, A and B, which were submitted to 7 and 8 minutes of total circulatory arrest, respectively, using "Inflow Occlusion" technique. Normothermia was tried during surgical procedures. Clinical and behavior evaluation were performed after surgery to

  2. Reassessment of seismic hazards at the Los Alamos National Laboratory

    International Nuclear Information System (INIS)

    Wong, I.G.; Hemphill-Haley, M.A.; Kelson, K.I.; Gardner, J.N.; House, L.S.


    A comprehensive seismic hazards evaluation program has been initiated at the Los Alamos National Laboratory (LANL) to update the current seismic design criteria. In part, this program has been motivated by recent studies which suggest that faults of the nearby Pajarito fault system may be capable of generating a large magnitude earthquake (M > 7). The specific objectives of this program are to: (1) characterize the tectonic setting of the LANL area; (2) characterize the nature, amount, and timing of late Quaternary fault displacements; (3) reevaluate the recorded seismicity in the LANL region to allow for the evaluation of seismogenic faults and the tectonic state of stress; (4) characterize the subsurface geologic conditions beneath the LANL required for the estimation of strong ground motions and site response; (5) estimate potential strong ground shaking both deterministically and probabilistically; and (6) develop the appropriate seismic design criteria. The approach and initial results of this seismic hazards program are described in this paper

  3. The Effect of 400 µg Inhaled Salbutamol on 3 km Time Trial Performance in a Low Humidity Environment

    Directory of Open Access Journals (Sweden)

    John Molphy, John W. Dickinson, Neil J. Chester, Mike Loosemore, Gregory Whyte


    Full Text Available The Objectives of the study were to investigate whether 400 µg inhaled salbutamol influences 3 km running time-trial performance and lung function in eucapnic voluntary hyperpnoea positive (EVH+ve and negative (EVH-ve individuals. Fourteen male participants (22.4 ± 1.6yrs; 76.4 ± 8.7kg; 1.80 ± 0.07 m; (7 EVH+ve; 7 EVH-ve were recruited following written informed consent. All participants undertook an EVH challenge to identify either EVH+ve (↓FEV1>10% or EVH-ve (↓FEV110% from baseline in FEV1 following any time-trial. Administration of 400µg inhaled salbutamol does not improve 3 km time-trial performance in either mild EVH+ve or EVH–ve individuals despite significantly increased HR and FEV1.

  4. Unusual Childhood Waking as a Possible Precursor of the 1995 Kobe Earthquake

    Directory of Open Access Journals (Sweden)

    Neil E. Whitehead


    Full Text Available Nearly 1,100 young students living in Japan at a range of distances up to 500 km from the 1995 Kobe M7 earthquake were interviewed. A statistically significant abnormal rate of early wakening before the earthquake was found, having exponential decrease with distance and a half value approaching 100 km, but decreasing much slower than from a point source such as an epicentre; instead originating from an extended area of more than 100 km in diameter. Because an improbably high amount of variance is explained, this effect is unlikely to be simply psychological and must reflect another mechanism—perhaps Ultra-Low Frequency (ULF electromagnetic waves creating anxiety—but probably not 222Rn excess. Other work reviewed suggests these conclusions may be valid for animals in general, not just children, but would be very difficult to apply for practical earthquake prediction.

  5. Interaction between two subducting plates under Tokyo and its possible effects on seismic hazards (United States)

    Wu, Francis; Okaya, David; Sato, Hiroshi; Hirata, Naoshi


    Underneath metropolitan Tokyo the Philippine Sea plate (PHS) subducts to the north on top of the westward subducting Pacific plate (PAC). New, relatively high-resolution tomography images the PHS as a well-defined subduction zone under western Kanto Plain. As PAC shoals under eastern Kanto, the PHS lithosphere is being thrusted into an increasingly tighter space of the PAC-Eurasian mantle wedge. As a result, zones of enhanced seismicity appear under eastern Kanto at the top of PHS, internal to PHS and also at its contact with PAC. These zones are located at depths greater than the causative fault of the disastrous 1923 Great Tokyo ``megathrust'' earthquake, in the vicinity of several well-located historical, damaging (M6 and M7) earthquakes. Thus a rather unique interaction between subducting plates under Tokyo may account for additional seismic hazards in metropolitan Tokyo.

  6. Overview of the critical disaster management challenges faced during Van 2011 earthquakes. (United States)

    Tolon, Mert; Yazgan, Ufuk; Ural, Derin N; Goss, Kay C


    On October 23, 2011, a M7.2 earthquake caused damage in a widespread area in the Van province located in eastern Turkey. This strong earthquake was followed by a M5.7 earthquake on November 9, 2011. This sequence of damaging earthquakes led to 644 fatalities. The management during and after these earthquake disaster imposed many critical challenges. In this article, an overview of these challenges is presented based on the observations by the authors in the aftermath of this disaster. This article presents the characteristics of 2011 Van earthquakes. Afterward, the key information related to the four main phases (ie, preparedness, mitigation, response, and recovery) of the disaster in Van is presented. The potential strategies that can be taken to improve the disaster management practice are identified, and a set of recommendations are proposed to improve the existing situation.

  7. Inelastic scattering of 275 keV neutrons by silver

    International Nuclear Information System (INIS)

    Litvinsky, L.L.; Zhigalov, Ya.A.; Krivenko, V.G.; Purtov, O.A.; Sabbagh, S.


    Neutron total, elastic and inelastic scattering cross-scattering of Ag at the E n = 275 KeV neutron energy were measured by using the filtered neutron beam of the WWR-M reactor in Kiev. The d-neutron strength function S n2 of Ag was determined from the analysis of all available data in the E n ≤ keV energy region on neutron inelastic scattering cross-sections with excitation of the first isomeric levels I π m = 7/2 + , E m ∼ 90 keV of 107,109 Ag: S n2 = (1.03 ± 0.19) · 10 -4 . (author). 10 refs, 3 figs

  8. 2001 Bhuj, India, earthquake engineering seismoscope recordings and Eastern North America ground-motion attenuation relations (United States)

    Cramer, C.H.; Kumar, A.


    Engineering seismoscope data collected at distances less than 300 km for the M 7.7 Bhuj, India, mainshock are compatible with ground-motion attenuation in eastern North America (ENA). The mainshock ground-motion data have been corrected to a common geological site condition using the factors of Joyner and Boore (2000) and a classification scheme of Quaternary or Tertiary sediments or rock. We then compare these data to ENA ground-motion attenuation relations. Despite uncertainties in recording method, geological site corrections, common tectonic setting, and the amount of regional seismic attenuation, the corrected Bhuj dataset agrees with the collective predictions by ENA ground-motion attenuation relations within a factor of 2. This level of agreement is within the dataset uncertainties and the normal variance for recorded earthquake ground motions.

  9. [Monoclonal antibodies in diagnosis of acute leukemias]. (United States)

    Krawczyńska, A; Robak, T


    Immunophenotyping has become an essential component for the study of acute myeloblastic (AML) and lymphoblastic (ALL) leukaemias. The recent development of highly specific monoclonal antibodies (Mc Ab) to differentiation antigens (CD) of haematopoetic cells have made it readily available to clinical laboratories in most major hospitals. Immunophenotyping complements standard morphology by providing information on lineage, stage of differentiation and clonality. In addition some of the flow cytometry findings have independent prognostic significance. Monoclonal antibodies useful in defining lineage (B-cell versus T-cell) and stages of differentiation of ALL. It can be also used in identifying characteristic feature of AML and aiding in lineage determination in acute leukaemias that are morphologically undifferentiated. Surface immunophenotyping is especially helpful for recognizing mixed lineage acute leukaemia and diagnosing certain rare entities such as erythroleukaemia (M6), acute megakaryocytic leukaemia (M7) and minimally differentiation acute myeloid leukaemia.

  10. Experimental researches of nuclear reactor neutron and gamma radiation scattering into the atmosphere

    International Nuclear Information System (INIS)

    Istomin, Yu.L.; Zelensky, D.I.; Cherepnin, Yu.S.; Orlov, Yu.V.; Netecha, M.E.; Avaev, V.N.; Vasel'ev, G.A.; Sakamoto, H.; Nomura, Y.; Naito, Y.


    In the report there are results of measuring radiation distribution on the caps of the RA and IWG.1M research reactors. Comparative analysis of the results is also in the report. There are neutron spectra in the interval of energies from 10 -9 to 13 MeV above RA and IWG.1M reactors. The spectra were measured with a set of activation detectors. Measurements were calculated to a nominal rate: for RA reactor - 300 kw, for IWG.1M - 7 MW. Thus, in the course of the experiment, vast experimental information relating to distribution of the RA and IWG.1M reactor gamma and neutron radiation scattered in the air for distances varying from 50 to 1000 m from the reactors has become available. The data obtained are to be used to verify the calculation codes and to validate the group nuclear constants

  11. Structure and composition of magnetocaloric Ni-Mn-In-Co thin films on the nanoscale - a TEM study

    Energy Technology Data Exchange (ETDEWEB)

    Erkartal, Burak; Schuermann, Ulrich; Kienle, Lorenz [Institute for Materials Science, Synthesis and Real Structure, Christian Albrechts University, Kiel (Germany); Duppel, Viola [Nanochemistry Max Planck Institute for Solid State Research, Stuttgart (Germany); Niemann, Robert; Schultz, Ludwig; Faehler, Sebastian [IFW Dresden (Germany)


    A complementary set of electron microscopy techniques is applied for the determination of structural and chemical segregation phenomena within a 300 nm thick metamagnetic Ni-Mn-In-Co thin film. The structure is predominantly composed of distinct modulated martensites of the 5M-, 6M-, 7M-, and 8M-type. Additionally these modulated structures exhibit twinning and stacking disordering. The nature of the disordering and the structural misfit at the twin interface were analyzed via high resolution micrographs. Next to an adhesion layer of Cr interdiffusion on the nanoscale was observed producing a penternary chemically and structurally homogeneous precipitate. The structure can be assigned to a twinned non-modulated pseudocubic model. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  12. From Tornadoes to Earthquakes: Forecast Verification for Binary Events Applied to the 1999 Chi-Chi, Taiwan,Earthquake

    Directory of Open Access Journals (Sweden)

    Chien-Chih Chen


    Full Text Available Forecast verification procedures for statistical events with binary outcomes typically rely on the use of contingency tables and Relative Operating Characteristic (ROC diagrams. Originally developed for the statistical evaluation of tornado forecasts on a county-by-county basis, these methods can be adapted to the evaluation of competing earthquake forecasts. Here we apply these methods retrospectively to two forecasts for the M 7.3 1999 Chi-Chi, Taiwan, earthquake. We show that a previously proposed forecast method that is based on evaluating changes in seismic intensity on a regional basis is superior to a forecast based only on the magnitude of seismic intensity in the same region. Our results confirm earlier suggestions that the earthquake preparation process for events such as the Chi-Chi earthquake involves anomalous activation or quiescence, and that signatures of these processes can be detected in seismicity data using appropriate methods.

  13. Metabolism of T-2 toxin in rats: Effects of dose, route, and time

    International Nuclear Information System (INIS)

    Pfeiffer, R.L.; Swanson, S.P.; Buck, W.B.


    Metabolic profiles of the excreta from rats following iv, oral, and dermal administration of tritium-labeled T-2 toxin at 0.15 and 0.60 mg/kg were determined. The major metabolites in urine were 3'-OH HT-2, T-2 tetraol, and unknown metabolite M5, whereas the major metabolites in feces were deepoxy T-2 tetraol, 3'-OH HT-2, and unknown metabolites M5, M7, and M9. The metabolite labeled M9 (major metabolite) was tentatively identified as deepoxy 3'-OH HT-2. There was no significant effect on metabolic profiles due to dose, but there was a variable effect associated with the route of administration. The increase over time of appreciable levels of deepoxy metabolites as a percentage of extracted radioactivity was both consistent and statistically significant

  14. The Elizabeth Lake paleoseismic site: Rupture pattern constraints for the past ~800 years for the Mojave section of the south-central San Andreas Fault (United States)

    Bemis, Sean; Scharer, Katherine M.; Dolan, James F.; Rhodes, Ed


    The southern San Andreas Fault in California has hosted two historic surface-rupturing earthquakes, the ~M7 1812 Wrightwood earthquake and the ~M7.9 1857 Fort Tejon earthquake (e.g., Sieh, 1978; Jacoby et al., 1988). Numerous paleoseismic studies have established chronologies of historic and prehistoric earthquakes at sites along the full length of the 1857 rupture (e.g., Sieh, 1978; Scharer et al., 2014). These studies provide an unparalleled opportunity to examine patterns of recent ruptures; however, at least two significant spatial gaps in high-quality paleoseismic sites remain. At ~100 km long each, these gaps contribute up to 100 km of uncertainty to paleo-rupture lengths and could also permit a surface rupture from an earthquake up to ~M7.2 to go undetected [using scaling relationships of Wells and Coppersmith (1994)]. Given the known occurrence of an ~M7 earthquake on this portion of the SAF (1812), it is critical to fill these gaps in order to better constrain paleo-rupture lengths and to increase the probability of capturing the full spatial record of surface rupturing earthquakes.   In this study, we target a new site within the 100 km long stretch of the San Andreas Fault between the Frazier Mountain and Pallett Creek paleoseismic sites (Figure 1), near Elizabeth Lake, California. Prior excavations at the site during 1998-1999 encountered promising stratigraphy but these studies were hindered by shallow groundwater throughout the site. We began our current phase of investigations in 2012, targeting the northwestern end of a 40 x 350 m fault-parallel depression that defines the site (Figure 2). Subsequent investigations in 2013 and 2014 focused on the southeastern end of the depression where the fault trace is constrained between topographic highs and is proximal to an active drainage. In total, our paleoseismic investigations consist of 10 fault-perpendicular trenches that cross the depression (Figure 2) and expose a >2000 year depositional record

  15. Determination of fast neutron fluence at WWER-1000 pressure vessel

    International Nuclear Information System (INIS)

    Valenta, V. et al.


    The influence function method is an effective tool making it possible, by means of tabulated values to rapidly perform three-dimensional calculations of fast neutron fluences for various reactor core loadings and for various nuclear power plant units. The procedure for determining the spatial dependence of the fast neutron fluences in a WWER-1000 pressure vessel is described. For this, the reactor core is divided into sufficiently fine volume elements within which the neutron source can be regarded as coordinate-independent. The influence functions point to a substantial role of sources lying at the reactor core periphery. In WWER-1000 reactors, only 1 or 2 rows of peripheral assemblies are important. The influence function method makes possible a rapid and easy determination of preconditions for the assessment of the residual lifetime of the pressure vessel based on the actual reactor core loadings. (Z.M.). 7 figs., 8 refs


    Energy Technology Data Exchange (ETDEWEB)

    Route, Matthew, E-mail: [Research Computing, Information Technology at Purdue, Purdue University, 155 S. Grant Street, West Lafayette, IN 47907 (United States)


    The long-term magnetic behavior of objects near the cooler end of the stellar main sequence is poorly understood. Most theoretical work on the generation of magnetism in these ultracool dwarfs (spectral type ≥M7 stars and brown dwarfs) suggests that their magnetic fields should not change in strength and direction. Using polarized radio emission measurements of their magnetic field orientations, I demonstrate that these cool, low-mass, fully convective objects appear to undergo magnetic polarity reversals analogous to those that occur on the Sun. This powerful new technique potentially indicates that the patterns of magnetic activity displayed by the Sun continue to exist, despite the fully convective interiors of these objects, in contravention of several leading theories of the generation of magnetic fields by internal dynamos.

  17. Long-term predictability of regions and dates of strong earthquakes (United States)

    Kubyshen, Alexander; Doda, Leonid; Shopin, Sergey


    parameters and seismic events. Further development of the H-104 method is the plotting of H-104 trajectories in two-dimensional time coordinates. The method provides the dates of future earthquakes for several (3-4) sequential time intervals multiple of 104 days. The H-104 method could be used together with the empirical scheme for short-term earthquake prediction reducing the date uncertainty. Using the H-104 method, it is developed the following long-term forecast of seismic activity. 1. The total number of M6+ earthquakes expected in the time frames: - 10.01-07.02: 14; - 08.02-08.03: 17; - 09.03-06.04: 9. 3. The potential days of M6+ earthquakes expected in the period of 10.01.2016-06.04.2016 are the following: - in January: 17, 18, 23, 24, 26, 28, 31; - in February: 01, 02, 05, 12, 15, 18, 20, 23; - in March: 02, 04, 05, 07 (M7+ is possible), 09, 10, 17 (M7+ is possible), 19, 20 (M7+ is possible), 23 (M7+ is possible), 30; - in April: 02, 06. The work was financially supported by the Ministry of Education and Science of the Russian Federation (contract No. 14.577.21.0109, project UID RFMEFI57714X0109)

  18. Antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens

    Directory of Open Access Journals (Sweden)

    Marcele A. Ferreira

    Full Text Available The antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens is reported. The Minimal Inhibitory Concentrations (MICs for inhibiting the microorganisms growth were determined using the broth microdilution method from the CLSI M7-A7 protocol. Chlorhexidine was used as the positive control. The ethanol crude extract of the aerial parts of A. sellowiana exhibited activity against the microorganisms tested in this work; however, the activity decreased after partition with n-hexane, dichloromethane, and ethyl acetate. Among the tested fractions, the n-hexane fraction was found to be the most effective against the evaluated oral pathogens. GC-MS analysis of this latter fraction revealed that fatty acids esters, steroids, and aliphatic sesquiterpene hydrocarbons are its major constituents. These compounds may be responsible for the activity of the n-hexane fraction, but other chemical constituents of the dichloromethane, ethyl acetate, and hydroalcoholic fraction may potentialize their activities in the crude extract.

  19. Word Frequency Analysis. MOS: 05B. Skill Levels 1 & 2. (United States)


    UJMIII 1 r1 I1 P 11 rtiall 11 t _7r rI rs r1 ivr A’s1I I i -?Lq/rp-na I %flfTf’a 11 ( Pi*Ir 11 r 1% it ;Nc14 It Pt F’tAP𔃻 I[ T(P’tfPE(t I if Porn ...CCNTROL ?5 ST AI ION 21 FIRM 73 LInCA TI ON ?2 CIENERATnp 7t f!CS 70 Al, m 7 0 GRnUP _NT-wiAY 7𔄁 NtT ( 20 SITE 20 SUPPORT 14 AT 14 P le OPERATOR#S 19

  20. Ultra-cool dwarfs viewed equator-on: surveying the best host stars for biosignature detection in transiting exoplanets (United States)

    Miles-Paez, Paulo; Metchev, Stanimir; Burgasser, Adam; Apai, Daniel; Palle, Enric; Zapatero Osorio, Maria Rosa; Artigau, Etienne; Mace, Greg; Tannock, Megan; Triaud, Amaury


    There are about 150 known planets around M dwarfs, but only one system around an ultra-cool (>M7) dwarf: Trappist-1. Ultra-cool dwarfs are arguably the most promising hosts for atmospheric and biosignature detection in transiting planets because of the enhanced feature contrast in transit and eclipse spectroscopy. We propose a Spitzer survey to continuously monitor 15 of the brightest ultra-cool dwarfs over 3 days. To maximize the probability of detecting transiting planets, we have selected only targets seen close to equator-on. Spin-orbit alignment expectations dictate that the planetary systems around these ultra-cool dwarfs should also be oriented nearly edge-on. Any planet detections from this survey will immediately become top priority targets for JWST transit spectroscopy. No other telescope, present or within the foreseeable future, will be able to conduct a similarly sensitive and dedicated survey for characterizeable Earth analogs.

  1. The effect of isotopic mass on the velocity of sound in liquid Li

    International Nuclear Information System (INIS)

    McAlister, S.P.; Crozier, E.D.; Cochran, J.F.


    Results are presented for the velocity of ultrasound in liquid 6 Li- 7 Li alloys of composition 4.5, 49.7 and 99.9 at % Li for temperatures up to 700 0 C. At the melting point the ratio of the velocity of sound in 6 Li to that in 7 Li was found within experimental error to equal (M 7 /M 6 )sup(1/2), the result expected for classical liquids which differ only in the isotopic mass M. In the alloy of 49.7 at % 7 Li the sound velocity exceeded by 0.6% the value expected for a thermodynamically ideal alloy. This result is discussed in terms of the theoretical treatment by Parrinello et al, (J. Phys. C.: Solid St. Phys.; 7:2577 (1974)) of collective excitations in binary isotopic fluids. (author)

  2. Checking the special professional qualification of selected personnel of Czechoslovak nuclear power facilities

    International Nuclear Information System (INIS)

    Kovar, P.; Bahnova, V.


    The system of examinations of selected staff members of Czechoslovak nuclear power plants for their special professional quanlification is described in detail. This selected personnel includes secondary circuit operators, primary circuit operators, graduate shift leaders as well as reactor unit managers. Attention is paid to the structure, methodology, contents and criteria of evaluation of the written, oral and practical parts of the examination, which is sat for before the State Examination Commission. Based on the results of the examinations, the Czechoslovak Atomic Energy Commission grants, prolongs or cancels licenses for the particular functions. Over the period from 1985 to March 1989, 394 new licenses were issued, 93 licenses were prolonged and 4 were withdrawn. (Z.M.). 7 figs., 3 tabs., 3 refs

  3. In vivo quantification of brain metabolites by 1H-MRS using water as an internal standard

    DEFF Research Database (Denmark)

    Christiansen, P; Henriksen, O; Stubgaard, M


    in quantification of N-acetyl aspartate (NAA) concentration was about 1-2 mM (6-12%). Also in vivo a good linearity between water signal and selected voxel size was seen. The same was true for the studied metabolites, N-acetyl aspartate (NAA), creatine/phosphocreatine (Cr/PCr), and choline (Cho). Calculated average...... concentrations of NAA, Cr/PCr, and Cho in the occipital lobe of the brain in five healthy volunteers were (mean +/- 1 SD) 11.6 +/- 1.3 mM, 7.6 +/- 1.4 mM, and 1.7 +/- 0.5 mM. The results indicate that the method presented offers reasonable estimation of metabolite concentrations in the brain in vivo...

  4. Effect of Heat Treatment on the Microstructure and Hardness of 17Cr-0.17N-0.43C-1.7 Mo Martensitic Stainless Steel (United States)

    Krishna, S. Chenna; Gangwar, Narendra Kumar; Jha, Abhay K.; Pant, Bhanu; George, Koshy M.


    The microstructure and hardness of a nitrogen-containing martensitic stainless steel were investigated as a function of heat treatment using optical microscopy, electron microscopy, amount of retained austenite, and hardness measurement. The steel was subjected to three heat treatments: hardening, cryo treatment, and tempering. The hardness of the steel in different heat-treated conditions ranged within 446-620 HV. The constituents of microstructure in hardened condition were lath martensite, retained austenite, M23C6, M7C3, MC carbides, and M(C,N) carbonitrides. Upon tempering at 500 °C, two new phases have precipitated: fine spherical Mo2C carbides and needle-shaped Cr2N particles.

  5. Reconnaissance map showing thickness of volcanic ash deposits in the greater Hilo area, Hawaii (United States)

    Buchanan-Banks, Jane M.


    This study was undertaken to determine the thickness and distribution of volcanic ash deposits in the greater Hilo area, Hawaii, as a step toward evaluating their susceptibility to failure during earthquake shaking. On several occasions their instability has resulted in serious damage. For example, the 1868 earthquake (m=7+), following a prolonged rainy period, caused a debris flow of hillside ash deposits that killed 31 people in Wood Valley (Bringham, 1869). The 1973 Honomu earthquake (m=6.2) resulted in more damage from shaking to areas underlain by ash deposits in the older part of Hilo than in other areas, and soil slips in ash, as well as rockfalls, were common along the roads north of town (Nielsen and others, 1977). 

  6. Mapping radio emitting-region on low-mass stars and brown dwarfs

    Directory of Open Access Journals (Sweden)

    Hallinan G.


    Full Text Available Strong magnetic activity in ultracool dwarfs (UCDs, spectral classes later than M7 have emerged from a number of radio observations, including the periodic beams. The highly (up to 100% circularly polarized nature of the emission point to an effective amplification mechanism of the high-frequency electromagnetic waves – the electron cyclotron maser (ECM instability. Several anisotropic velocity distibution models of electrons, including the horseshoe distribution, ring shell distribution and the loss-cone distribution, are able to generate the ECM instability. A magnetic-field-aligned electric potential would play an significant role in the ECM process. We are developing a theoretical model in order to simulate ECM and apply this model to map the radio-emitting region on low-mass stars and brown dwarfs.

  7. 23 Ekim 2011 Tabanlı-Van Depreminin Sismik Jeomorfolojisi ve Doğu Anadolu’daki Aktif Tektonik Yapılarla Olan İlişkisi


    Özkaymak, Çağlar; Sözbilir, Hasan; Bozkurt, Erdin; Dirik, Kadir; Topal, Tamer; Alan, Hüseyin; Çağlan, Dündar


    Bu çalışma, 23 Ekim 2011 tarihindemeydana gelen Tabanlı-Van (M = 7.2) depreminin bölgenin aktif tektoniğiiçerisindeki konumunu açıklamayı amaçlamaktadır. Bu bağlamda Tabanlı-Van depremindensonra arazi çalışmaları yapılmış, depremle ilişkili deformasyon yapılarıincelenmiş ve arazi gözlemlerinden elde edilen veriler ile Van ili veçevresiyle ilgili olarak daha önce yapılmış aktif tektonik çalışmalarıkarşılaştırılarak değerlendirmeye gidilmiştir. Depremsırasında veya hemen sonrasında yeryüzünde/y...

  8. Effect of cerium and lanthanum on the microstructure and mechanical properties of AISI D2 tool steel

    International Nuclear Information System (INIS)

    Hamidzadeh, Mohammad Ali; Meratian, Mahmood; Saatchi, Ahmad


    AISI D2 tool steel has excellent wear resistance with high dimensional stability. This type of steel is suitable for making molds. This paper describes investigations into the effect of adding Ce/La on microstructure of AISI D2 type cold work tool steels obtained by means of optical microscopy, scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectrometry (EDS) and image analyzer. The results showed that after modification with Ce/La, the morphology, size and distribution of M 7 C 3 carbides change greatly. The carbide network tends to break, and all carbides are refined and distributed homogeneously in the matrix, and also reduce the size of chromium carbides and increase the dissolution of carbides during heat treatment. The results of mechanical tests show that the toughness of the alloy increased about 75% without reducing the hardness of the alloy

  9. [Leadership and management courses for clinicians]. (United States)

    Wichelhaus, Daniel; Fischer, Peter


    The aim of the present study was to evaluate the benefit of Leadership and Management Courses for clinicians, specifically which leadership and management contents are beneficial to their daily clinical work and whether these contents support their individual career. E-mail invitations to participate in the study were sent to all 543 medical doctors of the University Hospital Hanover, Germany, who had taken part in one of the leadership and management courses offered between June 2005 and June 2015. The enquiry was carried out between June 1 and June 30, 2015. 84 e-mail addresses were no longer active; and so, N=459 clinicians actually received the invitation. Of these, 104 participated (22.7%). The study included 59 items. Six were free text items, twelve items were closed questions which could be answered by choosing from a drop down menu, and 41 were answered on a Likert scale from 0 (not fitting at all) to 10 (perfect fit). Based on the items answered on a Likert scale, the following scales and mean values were deduced: Job Satisfaction (M=7.44); Leadership (M=7.77); Trust (M=7.22); Striving for Power (M=7,45); negative Affect (M=4,91); Target Achievement Motivation (M=8.19); Communication (M=8.30) and Management (M=6.48). Regression analysis showed that Job- and Team Satisfaction can predict to what extent the participants regard themselves as good leaders. The study participants defined the following topics as very important: leadership and management style, managerial functions, team management, human resources development and project management. Further topics included rhetoric skills, presentation techniques, as well as basic economics such as understanding balance sheets, profit & loss statements and contribution margin calculation. 55% of the course contents were described as being directly applicable to their daily working environment. In the clinicians' view, the ideal leader acts as a role model (passing on values like respect, appreciation, honesty

  10. Response of the Black Sea methane budget to massive short-term submarine inputs of methane

    DEFF Research Database (Denmark)

    Schmale, O.; Haeckel, M.; McGinnis, D. F.


    A steady state box model was developed to estimate the methane input into the Black Sea water column at various water depths. Our model results reveal a total input of methane of 4.7 Tg yr(-1). The model predicts that the input of methane is largest at water depths between 600 and 700 m (7......% of the total input), suggesting that the dissociation of methane gas hydrates at water depths equivalent to their upper stability limit may represent an important source of methane into the water column. In addition we discuss the effects of massive short-term methane inputs (e. g. through eruptions of deep......-water mud volcanoes or submarine landslides at intermediate water depths) on the water column methane distribution and the resulting methane emission to the atmosphere. Our non-steady state simulations predict that these inputs will be effectively buffered by intense microbial methane consumption...

  11. A Preliminary Survey of Terrestrial Plant Communities in the Sierra de los Valles

    Energy Technology Data Exchange (ETDEWEB)

    Randy G. Balice


    To more fully understand the species compositions and environmental relationships of high-elevation terrestrial plant communities in the Los Alamos region, 30 plots in randomly selected, upland locations were sampled for vegetation, topographic, and soils characteristics. The locations of these plots were constrained to be above 2,134 m (7,000 ft) above mean sea level. The field results were summarized, analyzed, and incorporated into a previously developed classification of vegetation and land cover types. The revised and updated discussions of the environmental relationships at these sites and their associated species compositions are included in this report. A key to the major land cover types in the Los Alamos region was also revised in accordance with the new information and included herein its entirety.

  12. Hydrolyzable tannins of tamaricaceous plants. V. Structures of monomeric-trimeric tannins and cytotoxicity of macrocyclic-type tannins isolated from Tamarix nilotica (1). (United States)

    Orabi, Mohamed A A; Taniguchi, Shoko; Sakagami, Hiroshi; Yoshimura, Morio; Yoshida, Takashi; Hatano, Tsutomu


    Three new ellagitannin monomers, nilotinins M5-M7 (1-3), a dimer, nilotinin D10 (4), and a trimer, nilotinin T1 (5), together with three known dimers, hirtellin D (7) and tamarixinins B (8) and C (9), and a trimer, hirtellin T2 (6), were isolated from Tamarix nilotica dried leaves. The structures of the tannins were elucidated by intensive spectroscopic methods and chemical conversions into known tannins. The new trimer (5) is a unique macrocyclic type whose monomeric units are linked together by an isodehydrodigalloyl and two dehydrodigalloyl moieties. Additionally, dimeric and trimeric macrocyclic-type tannins isolated from T. nilotica in this study were assessed for possible cytotoxic activity against four human tumor cell lines. Tumor-selective cytotoxicities of the tested compounds were higher than those of synthetic and natural potent cytotoxic compounds, including polyphenols, and comparable with those of 5-fluorouracil and melphalan.

  13. Low resolution spectroscopic investigation of Am stars using Automated method (United States)

    Sharma, Kaushal; Joshi, Santosh; Singh, Harinder P.


    The automated method of full spectrum fitting gives reliable estimates of stellar atmospheric parameters (Teff, log g and [Fe/H]) for late A, F, G, and early K type stars. Recently, the technique was further improved in the cooler regime and the validity range was extended up to a spectral type of M6 - M7 (Teff˜ 2900 K). The present study aims to explore the application of this method on the low-resolution spectra of Am stars, a class of chemically peculiar stars, to examine its robustness for these objects. We use ULySS with the Medium-resolution INT Library of Empirical Spectra (MILES) V2 spectral interpolator for parameter determination. The determined Teff and log g values are found to be in good agreement with those obtained from high-resolution spectroscopy.

  14. The 3H(α,γ)7Li reaction below Ec.m. = 1 MeV

    International Nuclear Information System (INIS)

    Brune, C.R.; Kavanagh, R.W.; Rolfs, C.


    The 3 H(α,γ) reaction, and its mirror 3 He(α,γ) are responsible for 7 Li production in the big bang. It has been demonstrated that the uncertainty in the 3 H(α,γ) reaction rate significantly affects the calculated amount of 7 Li, which is important for comparison to the observed 7 Li abundance and constraining the baryon density allowed by the standard big-bang model. Using specially prepared thin Ti- 3 H targets and an 85% high-purity germanium detector, the authors have measured the γ rays produced by the 3 H(α,γ) reaction for 50 c.m. 7 Li bound states, and angular distributions of the capture γ rays. The results are compared to previous experiments and nuclear model calculations

  15. Measuring coseismic displacements with point-like targets offset tracking

    KAUST Repository

    Hu, Xie; Wang, Teng; Liao, Mingsheng


    Offset tracking is an important complement to measure large ground displacements in both azimuth and range dimensions where synthetic aperture radar (SAR) interferometry is unfeasible. Subpixel offsets can be obtained by searching for the cross-correlation peak calculated from the match patches uniformly distributed on two SAR images. However, it has its limitations, including redundant computation and incorrect estimations on decorrelated patches. In this letter, we propose a simple strategy that performs offset tracking on detected point-like targets (PT). We first detect image patches within bright PT by using a sinc-like template from a single SAR image and then perform offset tracking on them to obtain the pixel shifts. Compared with the standard method, the application on the 2010 M 7.2 El Mayor-Cucapah earthquake shows that the proposed PT offset tracking can significantly increase the cross-correlation and thus result in both efficiency and reliability improvements. © 2013 IEEE.

  16. Influence of radioactive contaminants on absorbed dose estimates for radiopharmaceuticals

    International Nuclear Information System (INIS)

    Watson, E.E.; Stabin, M.G.


    Several popular radiopharmaceutical products contain low levels of radioactive contaminants. These contaminants increase the radiation absorbed dose to the patient without any increased benefit and, in some cases, with a decrease in image quality. The importance of a contaminant to the radiation dosimetry picture is a function of 1) the contaminant level, 2) the physical half-life of the contaminant, 3) the organ uptake and the biological half-time of the contaminant in the various body systems, and 4) the decay mode, energy, etc. of the contaminant. The general influence of these parameters is discussed in this paper; families of curves are included that reflect the changing importance of contaminant dosimetry with respect to the primary radionuclide as a function of these variables. Several specific examples are also given of currently used radiopharmaceutical products which can contain radioactive contaminants (I-123, In-111, Tl-201, Ir-191m, Rb-82, Au-195m). 7 references, 8 figures, 4 tables

  17. Prediction of strong ground motion based on scaling law of earthquake

    International Nuclear Information System (INIS)

    Kamae, Katsuhiro; Irikura, Kojiro; Fukuchi, Yasunaga.


    In order to predict more practically strong ground motion, it is important to study how to use a semi-empirical method in case of having no appropriate observation records for actual small-events as empirical Green's functions. We propose a prediction procedure using artificially simulated small ground motions as substitute for the actual motions. First, we simulate small-event motion by means of stochastic simulation method proposed by Boore (1983) in considering pass effects such as attenuation, and broadening of waveform envelope empirically in the objective region. Finally, we attempt to predict the strong ground motion due to a future large earthquake (M 7, Δ = 13 km) using the same summation procedure as the empirical Green's function method. We obtained the results that the characteristics of the synthetic motion using M 5 motion were in good agreement with those by the empirical Green's function method. (author)

  18. Smart infrastructure access policy: a highway towards more efficient road transport

    CSIR Research Space (South Africa)

    Kural, K


    Full Text Available > . : H / < C 5 , + > 1 3 + 8 1 / . . 1 : F ? C = / , 7 > . F I @ J K L : * + , 1 . 7 M , + > 7 3 C N 8 O . 7 , 0 B ) ? 1 , 3 + ? 6 ; 3 ? 7 ? + 7 H / ? + 0 5 3 / 1 ; . 0 . ? / 9 B P + 0 1 , 1 < 1 . Q R H P S : 8 T U V E J A V : W , + X Y 5 , + > : 8 O . 7... + 7 < 0 1 / , ? 6 ; . 0 . ? / 9 B : K e I 3 f _ A V : K / . 1 3 / , ? ^ ^ ^ J : 8 3 < 1 B ( 4 / , 9 ? g h i j k l m j n o p q r s r t u v t q w u p x t q p y z t u p { u t q | } z q ~  z o t ~ y € ~ p y €  ‚ ƒ „ … † ‡ ˆ ‰ Ł...

  19. Infiltração cutânea na leucemia megacariocítica aguda com expressão de CD56 Cutaneous infiltration in acute megakaryocytic leukemia with CD56 expression

    Directory of Open Access Journals (Sweden)

    Mariela G. Farias


    Full Text Available A LMA-M7 é um subtipo raro de leucemia mielóide aguda (LMA. Está freqüentemente associada a mielofibrose e representa um subtipo de mau prognóstico. Raramente apresenta infiltração em sítios extramedulares. O aspirado de medula óssea ou biópsia mostra uma população de células pleomórficas e basofílicas, que podem apresentar projeções citoplasmáticas. A utilização da imunofenotipagem é essencial para o diagnóstico de LMA-M7. O imunofenótipo característico apresenta uma população de células leucêmicas com ausência da maioria dos marcadores linfóides e mielóides de superfície, porém com expressão para os antígenos da linhagem megacariocítica: CD41a (complexo glicoprotéico IIb/IIIa, CD42b (glicoproteína Ib e/ou CD61 (glicoproteína IIIa, ou antígeno relacionado ao fator VIII. Freqüentemente, a coloração citoquímica Sudan Black para os blastos megacariocíticos é negativa; neste caso, foi positiva para 40% das células analisadas. A presença de CD56, cuja expressão aberrante em algumas leucemias mielóides é indicativo de mau prognóstico, pode estar associada à infiltração da pele.AML-M7 is a rare subtype of acute myeloid leukemia (AML. It is frequently associated with myelofibrosis and corresponds to a poor prognosis subtype. It rarely presents with infiltration at extramedullary sites. The bone marrow aspirate or biopsy identifies pleomorphic and basophilic cell populations that may present with cytoplasmatic projections. The use of immunophenotyping is essential for the diagnosis of AML-M7. The characteristic immunophenotype presents a leukemic cell population without most lymphoid and myeloid surface markers, but with an expression of the megakaryocytic antigens: CD41a (glycoprotein complex IIb/IIIa, CD42b (glycoprotein Ib and/or CD61 (glycoprotein IIIa, or the factor VIII-related antigen. The cytochemical stain Sudan Black is frequently negative for megakaryocytic blasts; in this case, it was

  20. Crystallization and structure of chromium cast iron with addition of Mo and Ni

    International Nuclear Information System (INIS)

    Pietrowski, S.


    The aim of the presented paper is to show the results of examination of the crystallization process using the method of thermal-derivative analysis (ATD) and the structure examination of chromium cast iron, chromium molybdenum c. i. and chromium molybdenum nickel c.i. It was found that molybdenum in amount over 2 wt % causes the crystallization of eutectic carbides M 23 C 6 and M 6 C. The M 23 C 6 carbide crystallizes upon the crystallization of eutectic carbides M 3 C and M 7 C 3 . It is shown that ATD method facilitates both interpretation and control of the crystallization as well as formation of the cast iron structure at the solid state. (author)

  1. A rapid and efficient preparation of [{sup 123}I]radiopharmaceuticals using a small HPLC Rocket[reg] column

    Energy Technology Data Exchange (ETDEWEB)

    Katsifis, Andrew [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia)]. E-mail:; Papazian, Vahan [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia); Jackson, Timothy [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia); Loc' h, Christian [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia)


    A simplified method for the rapid and efficient preparation of [{sup 123}I]radiopharmaceuticals is described. Three radiopharmaceuticals, [{sup 123}I]{beta}-CIT, [{sup 123}I]MIBG and [{sup 123}I]clioquinol, were synthesised and purified as model compounds. The radiotracers were labelled with iodine-123 using electrophilic oxidative conditions and purified by a compact semi-preparative reverse phase column (C-18, 3 {mu}m, 7x53 mm, Alltima Rocket[reg, Alltech] using aqueous-ethanol as HPLC solvents that were directly used for radiopharmaceutical formulation. The radiochemical purity of the radioiodinated tracers as assessed by analytical HPLC was higher than 99% with specific activity higher than 3 GBq/nmol. The total preparation time of a radiotracer ranged from 40 to 60 min and, starting from 3.7 GBq of iodine-123, more than 2.5 GBq of formulated radiopharmaceuticals were available for clinical investigations.

  2. Dollar Summary of Federal Supply Classification and Service Category by Company, FY 85. Part 10 (7035-9150). (United States)


    a a acca ala a an 1 am W n U A ( n U maA U n ( ) C U ) ( ) V )( 0ma, a 0 C Dc ( p0 . ma a D ( D C D 0 c 9 c 9 C 9 0 C amaw w w w w iu jw w L w u L L...0 o 40 N . ) V s N P N 00 Go (a in -W P7 r- 0 nN cl -. r -W (0 .4 (0 m7 cm I at .46 al) .v 4 CNI (1) to mn (7 v -(N (14 r in 00 N C4 7 r ( I .4 4 a a

  3. Possible application of underground leaching of uranium in ''sandstone'' deposits by drilling method

    International Nuclear Information System (INIS)

    Bareja, E.


    Underground leaching as the method for excavation of uranium from its sandstone deposits is applied in many countries. A preliminary examination of a possible use of this method to sandstone deposits in Poland suggests it to be analysed against the uranium mineralization, noted within sediments of the Lower Triassic age in the Peribaltic Syneclise in the Krynica Morska - Paslek area. Before a definite decision on such exploitation of uranium, geologic and hydrogeologic conditions should be studied of individual uranium-bearing beds, particularly their permeability and insulation by impermeable claystone series as well as extraction of uranium from its bearing sandstones. The depth at which uranium-bearing beds occur, forms a very important item. The depth at which uranium ores described in literature and exploited by this method occur, does not exceed 700 m. 7 refs. (author)

  4. Evaluation of End Mill Coatings

    Energy Technology Data Exchange (ETDEWEB)

    L. J. Lazarus; R. L. Hester,


    Milling tests were run on families of High Speed Steel (HSS) end mills to determine their lives while machining 304 Stainless Steel. The end mills tested were made from M7, M42 and T15-CPM High Speed Steels. The end mills were also evaluated with no coatings as well as with Titanium Nitride (TiN) and Titanium Carbo-Nitride (TiCN) coatings to determine which combination of HSS and coating provided the highest increase in end mill life while increasing the cost of the tool the least. We found end mill made from M42 gave us the largest increase in tool life with the least increase in cost. The results of this study will be used by Cutting Tool Engineering in determining which end mill descriptions will be dropped from our tool catalog.

  5. Structure change in 25 Cr - 20 Ni steels as a function of their Cr, Ni, Si and W content

    International Nuclear Information System (INIS)

    Gribaudo, L.M.; Durand, F.; Durand-Charre, M.


    The influence of varying the Cr, Ni, Si and W concentrations on the type and composition of the carbides of solidification and on the phase shift temperature is studied with 18 alloys of composition close to stainless steel-25-20 (AISI 310) composition. Experimental techniques used are differential thermal analysis, microprobe and scanning electron microscope. Crystallization is interpreted with the equilibrium diagram Ni-Cr-C. The formation of the interdendritic σ phase for a chromium rich alloys is interpreted with the phase equilibrium diagram of Fe-Ni-Cr-C. Mechanical properties and corrosion resistance are dependent on the morphology of the carbides M 7 C 3 and M 23 C 6 [fr

  6. Effect of deep cryogenic treatment on the microstructure and wear performance of Cr-Mn-Cu white cast iron grinding media (United States)

    Vidyarthi, M. K.; Ghose, A. K.; Chakrabarty, I.


    The phase transformation and grinding wear behavior of Cr-Mn-Cu white cast irons subjected to destabilization treatment followed by air cooling or deep cryogenic treatment were studied as a part of the development program of substitute alloys for existing costly wear resistant alloys. The microstructural evolution during heat treatment and the consequent improvement in grinding wear performance were evaluated with optical and scanning electron microscopy, X-ray diffraction analysis, bulk hardness, impact toughness and corrosion rate measurements, laboratory ball mill grinding wear test etc. The deep cryogenic treatment has a significant effect in minimizing the retained austenite content and converts it to martensite embedded with fine M7C3 alloy carbides. The cumulative wear losses in cryotreated alloys are lesser than those with conventionally destabilized alloys followed by air cooling both in wet and dry grinding conditions. The cryotreated Cr-Mn-Cu irons exhibit comparable wear performance to high chromium irons.

  7. Afterslip, tremor, and the Denali fault earthquake (United States)

    Gomberg, Joan; Prejean, Stephanie; Ruppert, Natalia


    We tested the hypothesis that afterslip should be accompanied by tremor using observations of seismic and aseismic deformation surrounding the 2002 M 7.9 Denali fault, Alaska, earthquake (DFE). Afterslip happens more frequently than spontaneous slow slip and has been observed in a wider range of tectonic environments, and thus the existence or absence of tremor accompanying afterslip may provide new clues about tremor generation. We also searched for precursory tremor, as a proxy for posited accelerating slip leading to rupture. Our search yielded no tremor during the five days prior to the DFE or in several intervals in the three months after. This negative result and an array of other observations all may be explained by rupture penetrating below the presumed locked zone into the frictional transition zone. While not unique, such an explanation corroborates previous models of megathrust and transform earthquake ruptures that extend well into the transition zone.

  8. Pre-visual detection of stress in pine forests (United States)

    Olson, C. E., Jr.


    Pre-visual, or early, detection of forest stress with particular reference to detection of attacks by pine bark beetles is discussed. Preliminary efforts to obtain early detection of attacks by pine bark beetles, using MSS data from the ERIM M-7 scanner, were not sufficiently successful to demonstrate an operational capability, but indicate that joint processing of the 0.71 to 0.73, 2.00 to 2.60, and 9.3 to 11.7 micrometer bands holds some promise. Ratio processing of transformed data from the 0.45 to 0.52, 1.55 to 2.60, and 4.5 to 5.5 or 9.3 to 11.7 micrometer regions appears even more promising.

  9. Plant Equipment Packages: Are they a Credible Deterrent to War (United States)



  10. Reduced Intensity Donor Peripheral Blood Stem Cell Transplant in Treating Patients With De Novo or Secondary Acute Myeloid Leukemia in Remission (United States)


    Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Secondary Acute Myeloid Leukemia

  11. Home and parenting resources available to siblings depending on their birth intention status. (United States)

    Barber, Jennifer S; East, Patricia L


    This study examines the differential availability of family and parenting resources to children depending on their birth planning status. The National Longitudinal Survey of Youth data were analyzed, 3,134 mothers and their 5,890 children (M = 7.1 years, range = 1 month-14.8 years), of whom 63% were intended at conception, 27% were mistimed, and 10% were unwanted. Fixed-effects models show that unwanted and mistimed children had fewer resources than intended siblings. Parents' emotional resources to older children decreased after the birth of a mistimed sibling. Findings suggest that cognitive and emotional resources are differentially available to children within a family depending on intention status and that unintended births lead to decreased parental resources for older children in the household.

  12. Advances in Ka-Band Communication System for CubeSats and SmallSats (United States)

    Kegege, Obadiah; Wong, Yen F.; Altunc, Serhat


    A study was performed that evaluated the feasibility of Ka-band communication system to provide CubeSat/SmallSat high rate science data downlink with ground antennas ranging from the small portable 1.2m/2.4m to apertures 5.4M, 7.3M, 11M, and 18M, for Low Earth Orbit (LEO) to Lunar CubeSat missions. This study included link analysis to determine the data rate requirement, based on the current TRL of Ka-band flight hardware and ground support infrastructure. Recent advances in Ka-band transceivers and antennas, options of portable ground stations, and various coverage distances were included in the analysis. The link/coverage analysis results show that Cubesat/Smallsat missions communication requirements including frequencies and data rates can be met by utilizing Near Earth Network (NEN) Ka-band support with 2 W and high gain (>6 dBi) antennas.

  13. The direct effects of inattention and hyperactivity/impulsivity on peer problems and mediating roles of prosocial and conduct problem behaviors in a community sample of children. (United States)

    Andrade, Brendan F; Tannock, Rosemary


    This study tested whether children's symptoms of inattention and hyperactivity/impulsivity were associated with peer problems and whether these associations were mediated by conduct problems and prosocial behaviors. A community sample of 500 children, including 245 boys and 255 girls, who ranged in age from 6 to 9 years (M = 7.6, SD = 0.91) were recruited. Teachers' report of children's inattention, hyperactivity/impulsivity, conduct problems, prosocial behaviors, and peer problems was collected. Symptoms of inattention and hyperactivity/impulsivity were significantly positively associated with peer problems. Conduct problems were associated with more peer problems and prosocial behaviors with less peer problems. Conduct problems and prosocial behaviors partially mediated the association between hyperactivity/impulsivity and peer problems and fully mediated the inattention-peer problems association. Findings show that prosocial behaviors and conduct problems are important variables that account for some of the negative impact of symptoms of inattention and hyperactivity/impulsivity on peer functioning.

  14. Cyclosporine, Pravastatin Sodium, Etoposide, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (United States)


    Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia

  15. Synthesis of 4-Methoxybenzoylhydrazones and Evaluation of Their Antiglycation Activity

    Directory of Open Access Journals (Sweden)

    Muhammad Taha


    Full Text Available A series of 4-methoxybenzoylhydrazones 1–30 was synthesized and the structures of the synthetic derivatives elucidated by spectroscopic methods. The compounds showed a varying degree of antiglycation activity, with IC50 values ranging between 216.52 and 748.71 µM, when compared to a rutin standard (IC50 = 294.46 ± 1.50 µM. Compounds 1 (IC50 = 216.52 ± 4.2 µM, 3 (IC50 = 289.58 ± 2.64 µM, 6 (IC50 = 227.75 ± 0.53 µM, 7 (IC50 = 242.53 ± 6.1 and 11 (IC50 = 287.79 ± 1.59 all showed more activity that the standard, and these compounds have the potential to serve as possible leads for drugs to inhibit protein glycation in diabetic patients. A preliminary SAR study was performed.

  16. Composición química de “oca” (Oxalis tuberosa, ‘arracacha’ (Arracaccia xanthorriza y ‘tarwi’ (Lupinus mutabilis. Formulación de una mezcla base para productos alimenticios

    Directory of Open Access Journals (Sweden)

    María Elena León Marroú


    Full Text Available El presente trabajo tuvo como objetivo formular una mezcla base a partir de cultivos nativos, la cual una vez estandarizada, se constituye en materia prima de alto valor nutricional para su utilización en la elaboración de productos alimenticios como: purés, papillas y productos de panificación, entre otros. Se seleccionaron tres cultivos andinos: un tubérculo, “oca” (Oxalis tuberosa; una raíz, ‘arracacha’ (Arracaccia xanthorriza y una leguminosa, ‘tarwi’ (Lupinus mutabilis. Se realizaron por triplicado análisis bromatológicos, de minerales y vitaminas. Se formularon 8 mezclas bases a diferentes proporciones de cultivos nativos. Se seleccionó la mezcla base identificada como M7 en proporción 1:1:2 (oca:arracacha:tarwi por presentar mayor valor nutricional.

  17. Composición química de “oca” (Oxalis tuberosa, ‘arracacha’ (Arracaccia xanthorriza y ‘tarwi’ (Lupinus mutabilis. Formulación de una mezcla base para productos alimenticios

    Directory of Open Access Journals (Sweden)

    Sandra Elizabeth Pagador Flores


    Full Text Available El presente trabajo tuvo como objetivo formular una mezcla base a partir de cultivos nativos, la cual una vez estandarizada, se constituye en materia prima de alto valor nutricional para su utilización en la elaboración de productos alimenticios como: purés, papillas y productos de panificación, entre otros. Se seleccionaron tres cultivos andinos: un tubérculo, “oca” (Oxalis tuberosa; una raíz, ‘arracacha’ (Arracaccia xanthorriza y una leguminosa, ‘tarwi’ (Lupinus mutabilis. Se realizaron por triplicado análisis bromatológicos, de minerales y vitaminas. Se formularon 8 mezclas bases a diferentes proporciones de cultivos nativos. Se seleccionó la mezcla base identificada como M7 en proporción 1:1:2 (oca:arracacha:tarwi por presentar mayor valor nutricional.

  18. Band Saw Blade Crack before and after Comparison and Analysis of Experiments (2

    Directory of Open Access Journals (Sweden)

    Gao Jin-gui


    Full Text Available Based on MJ3310 woodworking band saw machine as the research object, under the no-load and load of Vib system vibration signal acquisition, processing and analysis software of band saw blade transverse vibration test and the signal acquisition and analysis of the collected signals obtained: to determine the transverse vibration displacement 5.66μm ~ 7.86μm and the main vibration frequency between 624 Hz ~ 792 Hz, then saw blade crack at least 3 mm, need timely saw blade, cutting high hardness of wood band saw blade transverse vibration displacement and frequency will increase sharply. Can be generated according to the band saw blade crack before and after the changing rule of the horizontal vibration displacement and frequency of transverse vibration and scope, judgment and replacement time of saw blade saw blade defect types, which can fully rational utilization of saw blade work effectively.

  19. Microstructure and wear resistance of high chromium cast iron containing niobium

    Directory of Open Access Journals (Sweden)

    Zhang Zhiguo


    Full Text Available In the paper, the effect of niobium addition on the microstructure, mechanical properties and wear resistance of high chromium cast iron has been studied. The results show that the microstructure of the heat-treated alloys is composed of M7C3 and M23C6 types primary carbide, eutectic carbide, secondary carbide and a matrix of martensite and retained austenite. NbC particles appear both inside and on the edge of the primary carbides. The hardness of the studied alloys maintains around 66 HRC, not significantly affected by the Nb content within the selected range of 0.48%-0.74%. The impact toughness of the alloys increases with increasing niobium content. The wear resistance of the specimens presents little variation in spite of the increase of Nb content under a light load of 40 N. However, when heavier loads of 70 and 100 N are applied, the wear resistance increases with increasing Nb content.

  20. Psychomotor assessment of 2nd grade children of elementary school

    Directory of Open Access Journals (Sweden)

    Joyce Carvalho Silvério


    Full Text Available The psychomotor is a multidisciplinary science that incorporates motor, affective and cognitive aspects. This study aimed to measure the psychomotor skills to see if the results are within the expected for the age group studied and investigate whether there are differences between the performance of boys and girls. 91 children participated in this research. 59.3% were boys (M = 7.16 years, SD = 0.37 of the 2nd year of elementary school in a public school in the state of Minas Gerais-Brasil. The results of psychomotor tests of Oliveira (2014 indicated that the profile of children was within the expected range, according to the stages of development of psychomotor skills. The only statistically significant difference between the sexes appeared in the psychomotor skills "body schema", with higher average of children. It is suggested that more studies will be developed with children of different types of institutions to confront these findings.

  1. Mechanisms of metal dusting corrosion

    DEFF Research Database (Denmark)

    Hummelshøj, Thomas Strabo

    In this thesis the early stages of metal dusting corrosion is addressed; the development of carbon expanded austenite, C, and the decomposition hereof into carbides. Later stages of metal dusting corrosion are explored by a systematic study of stainless steel foils exposed to metal dusting...... deformed stainless steel flakes is transformed to expanded martensite/austenite during low-temperature carburization. Various experimental procedures to experimentally determine the concentration dependent diffusion coefficient of carbon in expanded austenite are evaluated. The most promising procedure...... powders and flakes. The nature of the decomposition products, carbides of the form M23C6 and M7C3, were evaluated by X-ray diffraction, light optical microscopy, scanning electron microscopy and thermodynamic modelling. The decomposition was found to be dependent on several parameters such as thermal...

  2. Thermal transitions in Fe-Ti-Cr-C quaternary system used as precursor during laser in situ carbide coating

    International Nuclear Information System (INIS)

    Singh, Anshul; Porter, Wallace D.; Dahotre, Narendra B.


    The temperature range of thermal transitions within the quaternary system (Fe, Ti, Cr, and C) and the thermal stability of the evolved phases were studied with the help of differential scanning calorimetry (DSC). DSC studies indicated that the major exothermic reactions (formation of carbides) take place within 850-1150 deg. C. The evolved phases (TiC, M 7 C 3 , Fe-Cr, and Fe 3 C) were characterized using X-ray diffraction (XRD). This multicomponent powder mixture was used as a precursor for synthesizing a composite coating on the surface of steel via laser surface engineering (LSE). The intended wear applications of the coating made thermal stability investigations vital. Experimental evaluation of thermal stability of the phases formed was done

  3. An earthquake scenario for the microzonation of Sofia and the vulnerability of structures designed according to the Eurocodes

    International Nuclear Information System (INIS)

    Paskaleva, I.; Dimova, S.; Panza, G.F.; Vaccari, F.


    The study of site effects and the microzonation of a part of the metropolitan Sofia, based on the modelling of seismic ground motion along three cross sections are performed. Realistic synthetic strong motion waveforms are computed for scenario earthquakes (M=7) applying a hybrid modelling method, based on the modal summation technique and finite differences scheme. The synthesized ground motion time histories are source and site specific. The site amplification is determined in terms of response spectra ratio (RSR). A suite of time histories and quantities of earthquake engineering interest are provided. The results of this study constitute a database that describes the ground shaking of the urban area. A case study of experiment-based assessment of vulnerability of a cast-in-situ single storey, industrial, reinforced concrete frame, designed according to Eurocodes 2 and 8 is presented. The main characteristics of damage index and story drift are discussed for the purposes of microzonation. (author)

  4. Gamma dose effects valuation on micro computing components; Evaluation des effets de la dose gamma sur les composants micro-informatiques

    Energy Technology Data Exchange (ETDEWEB)

    Joffre, F


    Robotics in hostile environment raises the problem of micro computing components resistance with gamma radiation cumulated dose. The current aim is to reach a dose of 3000 grays with industrial components. A methodology and an instrumentation adapted to test this type of components have been developed. The aim of this work is to present the advantages and disadvantages bound to the use of industrial components in the presence of gamma radiation. After an analysis of the criteria allowing to justify the technological choices, the different steps which characterize the selection and the assessment methodology used are explained. The irradiation and measures means now operational are mentioned. Moreover, the supply aspects of the chosen components for the design of an industrialized system is taken into account. These selection and assessment components contribute to the development and design of computers for civil nuclear robotics. (O.M.). 7 refs.

  5. Missing link between the Hayward and Rodgers Creek faults. (United States)

    Watt, Janet; Ponce, David; Parsons, Tom; Hart, Patrick


    The next major earthquake to strike the ~7 million residents of the San Francisco Bay Area will most likely result from rupture of the Hayward or Rodgers Creek faults. Until now, the relationship between these two faults beneath San Pablo Bay has been a mystery. Detailed subsurface imaging provides definitive evidence of active faulting along the Hayward fault as it traverses San Pablo Bay and bends ~10° to the right toward the Rodgers Creek fault. Integrated geophysical interpretation and kinematic modeling show that the Hayward and Rodgers Creek faults are directly connected at the surface-a geometric relationship that has significant implications for earthquake dynamics and seismic hazard. A direct link enables simultaneous rupture of the Hayward and Rodgers Creek faults, a scenario that could result in a major earthquake ( M = 7.4) that would cause extensive damage and loss of life with global economic impact.

  6. Identification of dominant male sterile mutants in rice (Oryza sativa L.)

    International Nuclear Information System (INIS)

    Zhu Xudong; Rutger, J.N.


    Genetic male sterile mutants 1783 and 1789 were selected from US variety Orion and Kaybonnet seeds treated by gamma irradiation. Investigation of fertility characterization of pollen and spikelets of these mutants were made by progeny tests in 1783 M 7 and 1789 M 6 generations. The results showed that genetic male sterile mutants 1783 and 1789 with the fertility segregating of 1 sterile: 1 fertile were controlled by a single dominant gene. The pollen staining of mutants characterized partial sterility. Open-pollinated seed set was about 30% and bagged seed set was only 0.3%-3.5%. It is concluded that dominant genetic male sterile is a useful tool in improvement of population for rice breeding

  7. Moderate-resolution spectral standards from lambda 5600 to lambda 9000 (United States)

    Allen, Lori E.; Strom, Karen M.


    We present a grid of stellar classification spectra of moderate resolution (R approximately 1500) in the range lambda lambda 5600-9000 A, compiled from high signal-to noise spectra of 275 stars, most in the open clusters Praesepe and M67. The grid covers dwarfs from types B8 through M5, giants from G8 through M7, and subgiants from F5 through K0. We catalog atomic and molecular absorption features useful for stellar classification, and demonstrate the use of luminosity-sensitive features to distinguish between late-type dwarf and giant stars. The entire database is made available in digital format on anonymous ftp and through the World Wide Web.

  8. Clinical Characteristics of Comorbid Narcissistic Personality Disorder in Patients With Borderline Personality Disorder. (United States)

    Hörz-Sagstetter, Susanne; Diamond, Diana; Clarkin, John F; Levy, Kenneth N; Rentrop, Michael; Fischer-Kern, Melitta; Cain, Nicole M; Doering, Stephan


    This study examines psychopathology and clinical characteristics of patients with borderline personality disorder (BPD) and comorbid narcissistic personality disorder (NPD) from two international randomized controlled trials. From a combined sample of 188 patients with BPD, 25 also fulfilled criteria for a comorbid diagnosis of NPD according to DSM-IV. The BPD patients with comorbid NPD, compared to the BPD patients without comorbid NPD, showed significantly more BPD criteria (M = 7.44 vs. M = 6.55, p personality disorders, and were more likely to meet criteria for full histrionic PD diagnosis (44.0% vs. 14.2%, p disorders (M = 2.68 vs. M = 3.75, p = .033). No differences could be found in general functioning, self-harming behavior, and suicide attempts.

  9. Treatment for Relapsed/Refractory AML Based on a High Throughput Drug Sensitivity Assay (United States)


    Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Chronic Myelomonocytic Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Myeloid Leukemia; Refractory Anemia With Excess Blasts

  10. Accuracy requirements on operational measurements in nuclear power plants with regard to balance methodology

    International Nuclear Information System (INIS)

    Holecek, C.


    Accurate in-service measurement is necessary for power balancing of nuclear power plants, i.e., the determination of fuel consumption, electric power generation, heat delivery and the degree of fuel power utilization. The only possible method of determining the input of total consumed energy from the fuel is the balance of the primary coolant circuit. This is because for the purposes of power balancing it is not possible to measure the amount of power generated from nuclear fuel. Relations are presented for the calculation of basic indices of the power balance. It is stated that for the purposes of power balancing and analyses the precision of measuring instrument at the input and output of balancing circuits is of primary importance, followed by the precision of measuring instruments inside balancing circuits and meters of auxiliary parameters. (Z.M.). 7 refs., 1 tab

  11. O mínimo de oxigênio na costa leste do Brasil entre 7-22ºS The minimum oxygen concentration in easthern Brasilian coast between 7-22ºS

    Directory of Open Access Journals (Sweden)

    Argeo Magliocca


    Full Text Available In the South Atlantic nearly the Brazilian coast, at low latitudes, the layer of minimum oxygen concentration shows distinct values between the Equatorial region (7ºS and the region limited by latitudes of 18-22ºS. In the vicinity of the Equator the minimum concentration is remarkably clear (2,0 ml/l at 7ºS and at 22ºS the minima values raise up to 4.0-4.5 ml/l. The minimum oxygen layer follows the isopynics surfaces (σt = 26.8-27.2 in depths of 300-400 m (7ºS and 600-800 m (22ºS . The oxygen concentration in this area results from a biochemical and physical processes, due to the presence of poor water Brazil Current southward and the rich one Intermediate Antartic water flowing northward.

  12. Van earthquakes (23 October 2011 and 9 November 2011) and performance of masonry and adobe structures (United States)

    Güney, D.


    Earthquakes, which are unavoidable natural phenomena in Turkey, have often produced economic and social disaster. The latest destructive earthquakes happened in Van city. Van, Turkey, earthquakes with M = 7.2 occurred on 23 October 2011 at 13:41 (local time), whose epicenter was about 16 km north of Van (Tabanlı village) and M = 5.6 on 9 November 2011 epicentered near the town of Edremit south of Van in eastern Turkey and caused the loss of life and heavy damages. Both earthquakes killed 644 people and 2608 people were injured. Approximately 4000 buildings collapsed or were seriously damaged. The majority of the damaged structures were seismically insufficient, unreinforced masonry and adobe buildings in rural areas. In this paper, site surveys of the damaged masonry and adobe buildings are presented and the reasons for the caused damages are discussed in detail.

  13. Vorinostat in Treating Patients With Acute Myeloid Leukemia (United States)


    Adult Acute Erythroid Leukemia (M6); Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Acute Promyelocytic Leukemia (M3); Recurrent Adult Acute Myeloid Leukemia; Refractory Cytopenia With Multilineage Dysplasia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia

  14. Effect of Gamma Irradiation to Yellow Flesh Watermelon cv. ''Huay Sai Thong''

    International Nuclear Information System (INIS)

    Puripunyavanich, Vichai


    Yellow flesh watermelon seeds cv. Huay Sai Thong was irradiated with gamma rays. The experiment has been shown LD 50 dose at 420 Gy and GR 50 dose at 480 Gy approximately. Seeds of watermelon irradiated at 200 and 400 Gy were sown to find out mutation characteristics. The growth rate of M 1 plants was lower than the normal one. In M 2 plants, some irradiated lines showed non-dark green stripe on surface of fruit. Genetic testing was done according to skin color on watermelon fruit. It was found that the normal stripe characteristic was dominant and non-stripe characteristic was recessive. The Short length vine characteristic was selected till M 7 generation. The two lines of non-stripe watermelon and two lines of normal-stripe watermelon were selected for short length vine characteristic

  15. Ground motion for the design basis earthquake at the Savannah River Site, South Carolina based on a deterministic approach

    International Nuclear Information System (INIS)

    Youngs, R.R.; Coppersmith, K.J.; Silva, W.J.; Stephenson, D.E.


    Ground motion assessments are presented for evaluation of the seismic safety of K-Reactor at the Savannah River Site. Two earthquake sources were identified as the most significant to seismic hazard at the site, a M 7.5 earthquake occurring at Charleston, South Carolina, and a M 5 event occurring in the site vicinity. These events control the low frequency and high frequency portions of the spectrum, respectively. Three major issues were identified in the assessment of ground motions for the Savannah River site; specification of the appropriate stress drop for the Charleston source earthquake, specification of the appropriate levels of soil damping at large depths for site response analyses, and the appropriateness of western US recordings for specification of ground motions in the eastern US

  16. Safety and Immunogenicity of the HPV-16/18 AS04-adjuvanted Vaccine in 4-6-year-old Girls: Results to Month 12 From a Randomized Trial. (United States)

    Lin, Lan; Parra, Mercedes Macias; Sierra, Victor Y; Cespedes, Albino Salas; Granados, Maria Angelica; Luque, Adriana; Damaso, Silvia; Castrejon Alba, Maria Mercedes; Romano-Mazzotti, Luis; Struyf, Frank


    The burden of cervical cancer caused by human papillomavirus (HPV) is high in Latin America. The suboptimal HPV vaccination coverage in adolescents could be improved by pediatric immunization. HPV vaccination has not yet been reported in girls HPV-16/18 vaccine in 4-6-year-old girls. Healthy girls (randomized 1:1) received either 2 doses of AS04-HPV-16/18 vaccine (HPV group, N=74) or 1 dose of each measles-mumps-rubella and diphtheria-tetanus-acellular-pertussis vaccines (control group, N=74) 6 months apart. We report the safety and serum anti-HPV-16 and anti-HPV-18 antibodies (measured by enzyme-linked immunosorbent assay) up to 6 months postvaccination, that is, month (M) 12. Injection site pain was the most frequently reported solicited local symptom in HPV vaccinees. The incidence of other solicited and unsolicited symptoms after each vaccination was similar between the HPV and control group. Until M12, 1 girl in the HPV group and 2 in the control group reported serious adverse events; all serious adverse events were assessed as unrelated to study vaccines. No potential immune-mediated diseases were identified. All girls seroconverted for both antigens after 2 doses of AS04-HPV-16/18. In initially seronegative girls, anti-HPV-16 geometric mean concentrations were 20080.0 enzyme-linked immunosorbent assay units (EU)/mL at M7 and 3246.5 EU/mL at M12; anti-HPV-18 geometric mean concentrations were 10621.8 EU/mL at M7 and 1216.6 EU/mL at M12. Two-dose vaccination with AS04-HPV-16/18 was well tolerated and induced adequate antibody responses in 4-6-year-old girls.

  17. Immersion infection of germ-free zebrafish with Listeria monocytogenes induces transient expression of innate immune response genes

    Directory of Open Access Journals (Sweden)

    Ying eShan


    Full Text Available Zebrafish, Denio rerio, could be an alternative to other classic animal models for human infectious diseases to examine the processes of microbial infections and host-pathogen interactions in vivo because of their small body dimension but large clutch size. We established germ-free zebrafish infection models of Listeria monocytogenes through different routes of infection: oral immersion and injection via yolk sac, brain ventricle and blood island. Immersion of zebrafish larva even with 1010CFU/mL L. monocytogenes EGDe strain in egg water was unable to cause mortality, but GFP-expressing bacteria in the gut lumen could be observed in frozen sections. Several selected maker genes of the innate immune system, including cyp1a, irg1l, il1b and mmp9, were significantly induced by oral immersion not only with strain EGDe, but also with strain M7 and L. innocua, though to a lesser degree (P < 0.01. Such induction appears to be transient with peak at 48 h post-infection, but returned to basal level at 72 h post-infection. Of the three injection routes, mortality after infection by yolk sac was 80% in early stage of infection. Few eggs could survive and hatch. Injection into zebrafish embryos via brain ventricle or blood island led to progressive lethal infection. L. mocytogenes EGDe showed steady replication in the fish embryos and was far more pathogenic than strain M7, which is consistent with findings in the murine model. We conclude that zebrafish could serve as susceptible and microscopically visible infection models for L. monocytogenes via different routes and could be applied to further studies on the interactions between bacterial virulence factors and host immune responses.

  18. Fundamental questions of earthquake statistics, source behavior, and the estimation of earthquake probabilities from possible foreshocks (United States)

    Michael, Andrew J.


    Estimates of the probability that an ML 4.8 earthquake, which occurred near the southern end of the San Andreas fault on 24 March 2009, would be followed by an M 7 mainshock over the following three days vary from 0.0009 using a Gutenberg–Richter model of aftershock statistics (Reasenberg and Jones, 1989) to 0.04 using a statistical model of foreshock behavior and long‐term estimates of large earthquake probabilities, including characteristic earthquakes (Agnew and Jones, 1991). I demonstrate that the disparity between the existing approaches depends on whether or not they conform to Gutenberg–Richter behavior. While Gutenberg–Richter behavior is well established over large regions, it could be violated on individual faults if they have characteristic earthquakes or over small areas if the spatial distribution of large‐event nucleations is disproportional to the rate of smaller events. I develop a new form of the aftershock model that includes characteristic behavior and combines the features of both models. This new model and the older foreshock model yield the same results when given the same inputs, but the new model has the advantage of producing probabilities for events of all magnitudes, rather than just for events larger than the initial one. Compared with the aftershock model, the new model has the advantage of taking into account long‐term earthquake probability models. Using consistent parameters, the probability of an M 7 mainshock on the southernmost San Andreas fault is 0.0001 for three days from long‐term models and the clustering probabilities following the ML 4.8 event are 0.00035 for a Gutenberg–Richter distribution and 0.013 for a characteristic‐earthquake magnitude–frequency distribution. Our decisions about the existence of characteristic earthquakes and how large earthquakes nucleate have a first‐order effect on the probabilities obtained from short‐term clustering models for these large events.

  19. Foreshock occurrence before large earthquakes (United States)

    Reasenberg, P.A.


    Rates of foreshock occurrence involving shallow M ??? 6 and M ??? 7 mainshocks and M ??? 5 foreshocks were measured in two worldwide catalogs over ???20-year intervals. The overall rates observed are similar to ones measured in previous worldwide and regional studies when they are normalized for the ranges of magnitude difference they each span. The observed worldwide rates were compared to a generic model of earthquake clustering based on patterns of small and moderate aftershocks in California. The aftershock model was extended to the case of moderate foreshocks preceding large mainshocks. Overall, the observed worldwide foreshock rates exceed the extended California generic model by a factor of ???2. Significant differences in foreshock rate were found among subsets of earthquakes defined by their focal mechanism and tectonic region, with the rate before thrust events higher and the rate before strike-slip events lower than the worldwide average. Among the thrust events, a large majority, composed of events located in shallow subduction zones, had a high foreshock rate, while a minority, located in continental thrust belts, had a low rate. These differences may explain why previous surveys have found low foreshock rates among thrust events in California (especially southern California), while the worldwide observations suggests the opposite: California, lacking an active subduction zone in most of its territory, and including a region of mountain-building thrusts in the south, reflects the low rate apparently typical for continental thrusts, while the worldwide observations, dominated by shallow subduction zone events, are foreshock-rich. If this is so, then the California generic model may significantly underestimate the conditional probability for a very large (M ??? 8) earthquake following a potential (M ??? 7) foreshock in Cascadia. The magnitude differences among the identified foreshock-mainshock pairs in the Harvard catalog are consistent with a uniform

  20. Description and evaluation of GMXe: a new aerosol submodel for global simulations (v1

    Directory of Open Access Journals (Sweden)

    K. J. Pringle


    Full Text Available We present a new aerosol microphysics and gas aerosol partitioning submodel (Global Modal-aerosol eXtension, GMXe implemented within the ECHAM/MESSy Atmospheric Chemistry model (EMAC, version 1.8. The submodel is computationally efficient and is suitable for medium to long term simulations with global and regional models. The aerosol size distribution is treated using 7 log-normal modes and has the same microphysical core as the M7 submodel (Vignati et al., 2004.

    The main developments in this work are: (i the extension of the aerosol emission routines and the M7 microphysics, so that an increased (and variable number of aerosol species can be treated (new species include sodium and chloride, and potentially magnesium, calcium, and potassium, (ii the coupling of the aerosol microphysics to a choice of treatments of gas/aerosol partitioning to allow the treatment of semi-volatile aerosol, and, (iii the implementation and evaluation of the developed submodel within the EMAC model of atmospheric chemistry.

    Simulated concentrations of black carbon, particulate organic matter, dust, sea spray, sulfate and ammonium aerosol are shown to be in good agreement with observations (for all species at least 40% of modeled values are within a factor of 2 of the observations. The distribution of nitrate aerosol is compared to observations in both clean and polluted regions. Concentrations in polluted continental regions are simulated quite well, but there is a general tendency to overestimate nitrate, particularly in coastal regions (geometric mean of modelled values/geometric mean of observed data ≈2. In all regions considered more than 40% of nitrate concentrations are within a factor of two of the observations. Marine nitrate concentrations are well captured with 96% of modeled values within a factor of 2 of the observations.

  1. 3-D Spontaneous Rupture Simulations of the 2016 Kumamoto, Japan, Earthquake (United States)

    Urata, Yumi; Yoshida, Keisuke; Fukuyama, Eiichi


    We investigated the M7.3 Kumamoto, Japan, earthquake to illuminate why and how the rupture of the main shock propagated successfully by 3-D dynamic rupture simulations, assuming a complicated fault geometry estimated based on the distributions of aftershocks. The M7.3 main shock occurred along the Futagawa and Hinagu faults. A few days before, three M6-class foreshocks occurred. Their hypocenters were located along by the Hinagu and Futagawa faults and their focal mechanisms were similar to those of the main shock; therefore, an extensive stress shadow can have been generated on the fault plane of the main shock. First, we estimated the geometry of the fault planes of the three foreshocks as well as that of the main shock based on the temporal evolution of relocated aftershock hypocenters. Then, we evaluated static stress changes on the main shock fault plane due to the occurrence of the three foreshocks assuming elliptical cracks with constant stress drops on the estimated fault planes. The obtained static stress change distribution indicated that the hypocenter of the main shock is located on the region with positive Coulomb failure stress change (ΔCFS) while ΔCFS in the shallow region above the hypocenter was negative. Therefore, these foreshocks could encourage the initiation of the main shock rupture and could hinder the rupture propagating toward the shallow region. Finally, we conducted 3-D dynamic rupture simulations of the main shock using the initial stress distribution, which was the sum of the static stress changes by these foreshocks and the regional stress field. Assuming a slip-weakening law with uniform friction parameters, we conducted 3-D dynamic rupture simulations by varying the friction parameters and the values of the principal stresses. We obtained feasible parameter ranges to reproduce the rupture propagation of the main shock consistent with those revealed by seismic waveform analyses. We also demonstrated that the free surface encouraged

  2. The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells. (United States)

    Matsumura, I; Kanakura, Y; Kato, T; Ikeda, H; Horikawa, Y; Ishikawa, J; Kitayama, H; Nishiura, T; Tomiyama, Y; Miyazaki, H; Matsuzawa, Y


    Thrombopoietin (TPO) is implicated as a primary regulator of megakaryopoiesis and thrombopoiesis. However, the biologic effects of TPO on human acute myeloblastic leukemia (AML) cells are largely unknown. To determine if recombinant human (rh) TPO has proliferation-supporting and differentiation-inducing activities in AML cells, 15 cases of AML cells that were exclusively composed of undifferentiated leukemia cells and showed growth response to rhTPO in a short-term culture (72 hours) were subjected to long-term suspension culture with or without rhTPO. Of 15 cases, rhTPO supported proliferation of AML cells for 2 to 4 weeks in 4 cases whose French-American-British subtypes were M0, M2, M4, and M7, respectively. In addition to the proliferation-supporting activity, rhTPO was found to induce AML cells to progress to some degree of megakaryocytic differentiation at both morphologic and surface-phenotypic level in 2 AML cases with M0 and M7 subtypes. The treatment of AML cells with rhTPO resulted in rapid tyrosine phosphorylation of the TPO-receptor, c-mpl, and STAT3 in all of cases tested. By contrast, the expression of erythroid/megakaryocyte-specific transcription factors (GATA-1, GATA-2, and NF-E2) was markedly induced or enhanced in only 2 AML cases that showed megakaryocytic differentiation in response to rhTPO. These results suggested that, at least in a fraction of AML cases, TPO could not only support the proliferation of AML cells irrespective of AML subtypes, but could also induce megakaryocytic differentiation, possibly through activation of GATA-1, GATA-2, and NF-E2.

  3. Investigation of magnetocaloric effect in La{sub 0.45}Pr{sub 0.25}Ca{sub 0.3}MnO{sub 3} by magnetic, differential scanning calorimetry and thermal analysis

    Energy Technology Data Exchange (ETDEWEB)

    Aparnadevi, M; Barik, S K [Department of Physics, 2 Science Drive 3, National University of Singapore, Lower Kent Ridge Road, Singapore-117 452 (Singapore); Mahendiran, R [Department of Physics, 2 Science Drive 3, National University of Singapore, Lower Kent Ridge Road, Singapore-117 452 (Singapore)


    We investigated magnetocaloric effect in La{sub 0.45}Pr{sub 0.25}Ca{sub 0.3}MnO{sub 3} by direct methods (changes in temperature and latent heat) and indirect method (magnetization isotherms). This compound undergoes a first-order paramagnetic to ferromagnetic transition with T{sub C}=200 K upon cooling. The paramagnetic phase becomes unstable and it transforms into a ferromagnetic phase under the application of magnetic field, which results in a field-induced metamagnetic transition (FIMMT). The FIMMT is accompanied by release of latent heat and temperature of the sample as evidenced from differential scanning calorimetry and thermal analysis experiments. A large magnetic entropy change of {Delta}S{sub m}=-7.2 J kg{sup -1} K{sup -1} at T=212.5 K and refrigeration capacity of 228 J kg{sup -1} are found for a field change of {Delta}H=5 T. It is suggested that destruction of magnetic polarons and growth of ferromagnetic phase accompanied by a lattice volume change with increasing magnetic field is responsible for the large magnetocaloric effect in this compound. - Highlights: Black-Right-Pointing-Pointer We report magnetic entropy change measured by indirect and direct methods in La{sub 0.45}Pr{sub 0.25}Ca{sub 0.3}MnO{sub 3.} Black-Right-Pointing-Pointer Anomalous field-induced induced metamagnetic transition is found in the paramagnetic state. Black-Right-Pointing-Pointer A large reversible magnetic entropy change ({Delta}S{sub m}=7.2 J kg{sup -1} K{sup -1} for {Delta}H=5 T). Black-Right-Pointing-Pointer A large refrigeration capacity (RC=228 J kg{sup -1}). Black-Right-Pointing-Pointer Collapse of magnetic polarons is suggested as possible origin of the large MCE.

  4. Validation of S-NPP VIIRS Day-Night Band and M Bands Performance Using Ground Reference Targets of Libya 4 and Dome C (United States)

    Chen, Xuexia; Wu, Aisheng; Xiong, Xiaoxiong; Lei, Ning; Wang, Zhipeng; Chiang, Kwofu


    This paper provides methodologies developed and implemented by the NASA VIIRS Calibration Support Team (VCST) to validate the S-NPP VIIRS Day-Night band (DNB) and M bands calibration performance. The Sensor Data Records produced by the Interface Data Processing Segment (IDPS) and NASA Land Product Evaluation and Algorithm Testing Element (PEATE) are acquired nearly nadir overpass for Libya 4 desert and Dome C snow surfaces. In the past 3.5 years, the modulated relative spectral responses (RSR) change with time and lead to 3.8% increase on the DNB sensed solar irradiance and 0.1% or less increases on the M4-M7 bands. After excluding data before April 5th, 2013, IDPS DNB radiance and reflectance data are consistent with Land PEATE data with 0.6% or less difference for Libya 4 site and 2% or less difference for Dome C site. These difference are caused by inconsistent LUTs and algorithms used in calibration. In Libya 4 site, the SCIAMACHY spectral and modulated RSR derived top of atmosphere (TOA) reflectance are compared with Land PEATE TOA reflectance and they indicate a decrease of 1.2% and 1.3%, respectively. The radiance of Land PEATE DNB are compared with the simulated radiance from aggregated M bands (M4, M5, and M7). These data trends match well with 2% or less difference for Libya 4 site and 4% or less difference for Dome C. This study demonstrate the consistent quality of DNB and M bands calibration for Land PEATE products during operational period and for IDPS products after April 5th, 2013.

  5. Relaxation of the south flank after the 7.2-magnitude Kalapana earthquake, Kilauea Volcano, Hawaii (United States)

    Dvorak, John J.; Klein, Fred W.; Swanson, Donald A.


    An M = 7.2 earthquake on 29 November 1975 caused the south flank of Kilauea Volcano, Hawaii, to move seaward several meters: a catastrophic release of compression of the south flank caused by earlier injections of magma into the adjacent segment of a rift zone. The focal mechanisms of the mainshock, the largest foreshock, and the largest aftershock suggest seaward movement of the upper block. The rate of aftershocks decreased in a familiar hyperbolic decay, reaching the pre-1975 rate of seismicity by the mid-1980s. Repeated rift-zone intrusions and eruptions after 1975, which occurred within 25 km of the summit area, compressed the adjacent portion of the south flank, apparently masking continued seaward displacement of the south flank. This is evident along a trilateration line that continued to extend, suggesting seaward displacement, immediately after the M = 7.2 earthquake, but then was compressed during a series of intrusions and eruptions that began in September 1977. Farther to the east, trilateration measurements show that the portion of the south flank above the aftershock zone, but beyond the area of compression caused by the rift-zone intrusions and eruptions, continued to move seaward at a decreasing rate until the mid-1980s, mimicking the decay in aftershock rate. Along the same portion of the south flank, the pattern of vertical surface displacements can be explained by continued seaward movement of the south flank and development of two eruptive fissures along the east rift zone, each of which extended from a depth of ∼3 km to the surface. The aftershock rate and continued seaward movement of the south flank are reminiscent of crustal response to other large earthquakes, such as the 1966 M = 6 Parkfield earthquake and the 1983 M = 6.5 Coalinga earthquake.

  6. Seismic acceleration map expected for Japanese central region

    International Nuclear Information System (INIS)

    Sugiyama, Takeshi; Maeda, Kouji; Ishii, Kiyoshi; Suzuki, Makoto.


    Since electric generating and supplying facilities scatter in large areas, the seismic acceleration map, which defines the anticipated earthquake ground motions in a broad region, is very useful information for the design of those facilities against large earthquakes. This paper describes the development of a seismic acceleration map for the Central Japanese Region by incorporating the analytical results based on historical earthquake records and active fault data using probability and statistics. In the region, there have occurred several destructive earthquakes; Anseitokai (1854, M = 8.4) and Tohnankai (1944, M = 7.9) earthquakes along the Nankai trough; Nohbi (1891, M = 8.0) and Fukui (1948, M = 7.1) earthquakes in inland ares. Some of the historical earthquake data were obtained by instrument last one hundred years, whereas others by literary descriptions for nearly 1,000 years. The active fault data, have been collected mainly from the surveys of fault topography and geology, and are considered to indicate the average seismic activity for the past million years. A proposed seismic acceleration map for the return period of 75 years, calculated on the free surface of base stratum, was estimated by the following way. The analytical result based on the historical earthquake records was adopted mainly, because the Japanese seismic design criteria have been developed based on them. The proposed seismic acceleration map was revised by including the result based on the active fault data for the areas, where historical earthquake records lack, and the result was smoothed to evaluate the final seismic acceleration map. (author)

  7. Effective Beginning Handwriting Instruction: Multi-modal, Consistent Format for 2 Years, and Linked to Spelling and Composing. (United States)

    Wolf, Beverly; Abbott, Robert D; Berninger, Virginia W


    In Study 1, the treatment group ( N = 33 first graders, M = 6 years 10 months, 16 girls) received Slingerland multi-modal (auditory, visual, tactile, motor through hand, and motor through mouth) manuscript (unjoined) handwriting instruction embedded in systematic spelling, reading, and composing lessons; and the control group ( N =16 first graders, M = 7 years 1 month, 7 girls) received manuscript handwriting instruction not systematically related to the other literacy activities. ANOVA showed both groups improved on automatic alphabet writing from memory; but ANCOVA with the automatic alphabet writing task as covariate showed that the treatment group improved significantly more than control group from the second to ninth month of first grade on dictated spelling and recognition of word-specific spellings among phonological foils. In Study 2 new groups received either a second year of manuscript ( N = 29, M = 7 years 8 months, 16 girls) or introduction to cursive (joined) instruction in second grade ( N = 24, M = 8 years 0 months, 11 girls) embedded in the Slingerland literacy program. ANCOVA with automatic alphabet writing as covariate showed that those who received a second year of manuscript handwriting instruction improved more on sustained handwriting over 30, 60, and 90 seconds than those who had had only one year of manuscript instruction; both groups improved in spelling and composing from the second to ninth month of second grade. Results are discussed in reference to mastering one handwriting format before introducing another format at a higher grade level and always embedding handwriting instruction in writing and reading instruction aimed at all levels of language.

  8. Dopamine D1 receptor-dependent regulation of extracellular citrulline level in the rat nucleus accumbens during conditioned fear response. (United States)

    Saulskaya, Natalia B; Fofonova, Nellia V; Sudorghina, Polina V; Saveliev, Sergey A


    Nucleus accumbens (N.Acc) contains a subclass of nitric oxide (NO)-generating interneurons that are presumably regulated by the dopamine input. Receptor mechanisms underlying dopamine-NO interaction in the N.Acc are poorly understood. In the current study, we used in vivo microdialysis combined with high-performance liquid chromatography to examine participation of dopamine D1 receptors in regulation of extracellular levels of citrulline (an NO co-product) in the medial N.Acc of Sprague-Dawley rats during both pharmacological challenge and a conditioned fear response. The intraaccumbal infusion of the D1 receptor agonist SKF-38393 (100-500 microM) increased dose-dependently the local dialysate citrulline levels. The SKF-38393-induced increase in extracellular citrulline was prevented by intraaccumbal infusions of 500 microM 7-nitroindazole, a neuronal NO synthase inhibitor. In behavioral microdialysis experiment, the accumbal levels of extracellular citrulline markedly increased in rats given a mild footshock paired with tone. The presentation of the tone previously paired with footshock (the conditioned fear response) produced a "conditioned" rise of extracellular citrulline levels in the N.Acc which was attenuated by intraaccumbal infusion of 100 microM SCH-23390, a dopamine D1 receptor antagonist, and prevented by intraaccumbal infusion of 500 microM 7-nitroindazole. The results suggest that in the N.Acc, the dopamine D1 receptors might regulate the neuronal NO synthase activity; this dopamine-dependent mechanism seems to participate in activation of the neuronal NO synthase and probably NO formation in this brain area during the conditioned fear response.

  9. Crowd-Sourcing Seismic Data for Education and Research Opportunities with the Quake-Catcher Network (United States)

    Sumy, D. F.; DeGroot, R. M.; Benthien, M. L.; Cochran, E. S.; Taber, J. J.


    The Quake Catcher Network (QCN; uses low cost micro-electro-mechanical system (MEMS) sensors hosted by volunteers to collect seismic data. Volunteers use accelerometers internal to laptop computers, phones, tablets or small (the size of a matchbox) MEMS sensors plugged into desktop computers using a USB connector to collect scientifically useful data. Data are collected and sent to a central server using the Berkeley Open Infrastructure for Network Computing (BOINC) distributed computing software. Since 2008, sensors installed in museums, schools, offices, and residences have collected thousands of earthquake records, including the 2010 M8.8 Maule, Chile, the 2010 M7.1 Darfield, New Zealand, and 2015 M7.8 Gorkha, Nepal earthquakes. In 2016, the QCN in the United States transitioned to the Incorporated Research Institutions for Seismology (IRIS) Consortium and the Southern California Earthquake Center (SCEC), which are facilities funded through the National Science Foundation and the United States Geological Survey, respectively. The transition has allowed for an influx of new ideas and new education related efforts, which include focused installations in several school districts in southern California, on Native American reservations in North Dakota, and in the most seismically active state in the contiguous U.S. - Oklahoma. We present and describe these recent educational opportunities, and highlight how QCN has engaged a wide sector of the public in scientific data collection, particularly through the QCN-EPIcenter Network and NASA Mars InSight teacher programs. QCN provides the public with information and insight into how seismic data are collected, and how researchers use these data to better understand and characterize seismic activity. Lastly, we describe how students use data recorded by QCN sensors installed in their classrooms to explore and investigate felt earthquakes, and look towards the bright future of the network.

  10. Ambient vibrations of unstable rock slopes - insights from numerical modeling (United States)

    Burjanek, Jan; Kleinbrod, Ulrike; Fäh, Donat


    The recent events in Nepal (2015 M7.8 Gorkha) and New Zealand (2016 M7.8 Kaikoura) highlighted the importance of earthquake-induced landslides, which caused significant damages. Moreover, landslide created dams present a potential developing hazard. In order to reduce the costly consequences of such events it is important to detect and characterize earthquake susceptible rock slope instabilities before an event, and to take mitigation measures. For the characterisation of instable slopes, acquisition of ambient vibrations might be a new alternative to the already existing methods. We present both observations and 3D numerical simulations of the ambient vibrations of unstable slopes. In particular, models of representative real sites have been developed based on detailed terrain mapping and used for the comparison between synthetics and observations. A finite-difference code has been adopted for the seismic wave propagation in a 3D inhomogeneous visco-elastic media with irregular free surface. It utilizes a curvilinear grid for a precise modeling of curved topography and local mesh refinement to make computational mesh finer near the free surface. Topographic site effects, controlled merely by the shape of the topography, do not explain the observed seismic response. In contrast, steeply-dipping compliant fractures have been found to play a key role in fitting observations. Notably, the synthetized response is controlled by inertial mass of the unstable rock, and by stiffness, depth and network density of the fractures. The developed models fit observed extreme amplification levels (factors of 70!) and show directionality as well. This represents a possibility to characterize slope structure and infer depth or volume of the slope instability from the ambient noise recordings in the future.

  11. Reassessment of probabilistic seismic hazard in the Marmara region (United States)

    Kalkan, Erol; Gulkan, Polat; Yilmaz, Nazan; Çelebi, Mehmet


    In 1999, the eastern coastline of the Marmara region (Turkey) witnessed increased seismic activity on the North Anatolian fault (NAF) system with two damaging earthquakes (M 7.4 Kocaeli and M 7.2 D??zce) that occurred almost three months apart. These events have reduced stress on the western segment of the NAF where it continues under the Marmara Sea. The undersea fault segments have been recently explored using bathymetric and reflection surveys. These recent findings helped scientists to understand the seismotectonic environment of the Marmara basin, which has remained a perplexing tectonic domain. On the basis of collected new data, seismic hazard of the Marmara region is reassessed using a probabilistic approach. Two different earthquake source models: (1) the smoothed-gridded seismicity model and (2) fault model and alternate magnitude-frequency relations, Gutenberg-Richter and characteristic, were used with local and imported ground-motion-prediction equations. Regional exposure is computed and quantified on a set of hazard maps that provide peak horizontal ground acceleration (PGA) and spectral acceleration at 0.2 and 1.0 sec on uniform firm-rock site condition (760 m=sec average shear wave velocity in the upper 30 m). These acceleration levels were computed for ground motions having 2% and 10% probabilities of exceedance in 50 yr, corresponding to return periods of about 2475 and 475 yr, respectively. The maximum PGA computed (at rock site) is 1.5g along the fault segments of the NAF zone extending into the Marmara Sea. The new maps generally show 10% to 15% increase for PGA, 0.2 and 1.0 sec spectral acceleration values across much of Marmara compared to previous regional hazard maps. Hazard curves and smooth design spectra for three site conditions: rock, soil, and soft-soil are provided for the Istanbul metropolitan area as possible tools in future risk estimates.

  12. Microstructural Evolution of NiCrBSi Coatings Fabricated by Stationary Local Induction Cladding (United States)

    Chen, Xuliang; Qin, Xunpeng; Gao, Kai; Zhu, Zhenhua; Huang, Feng


    The development of induction cladding has been restricted by the complicated geometric characteristics of workpieces and the large heat-affected zone in the cladded workpieces. In this paper, three-dimensional continual local induction cladding (3D-CLIC) was proposed as a potential process to clad coating over a substrate with curved surface, and a stationary local induction cladding (SLIC) experiment was conducted as an exploratory study of 3D-CLIC. The microstructures and microhardness in the coatings were measured by SEM, EDS, XRD and microsclerometer, respectively. The results indicate that the coating is metallurgically bonded with the substrate without any defects. A compositional gradient exists in the diffusion transfer belt (DTB), and it decreases with the increase in induction heating time. The coating is mainly composed of (Fe, Ni), CrB, M7C3, Ni3B, Ni3Si and M23C6 (M = Cr, Ni, Fe). Among the carbides, M7C3 presents several morphologies and M23C6 is always attached to the DTB. A special phenomenon of texture was found in the SLIC coatings. The preferred orientation in (200) crystal plane or the restrained orientation in (111) (200) crystal plane becomes more obvious as the scanning speed increases. The maximum average microhardness is 721 HV when the coating is heated for 5 s. The wear loss of different samples increases with increasing induction heating time. The longer heating time would result in higher dilution in the SLIC coatings due to the complete mixing with the substrate, thus leading to the decrease in microhardness and wear loss.

  13. The in vitro transcription of a rainbow trout (Salmo gairdnerii) protamine gene. II. Controlled mutation of the cap site region. (United States)

    Jankowski, J M; Dixon, G H


    A series of plasmids containing new fusion genes in which the trout protamine gene is placed under the control of the complete herpes virus (HSV-1) tk promoter Pvu II-Bgl II fragment (pM8), or a shortened thymidine kinase (tk) promoter in which the region between the TATA box and the cap site is altered by using the Pvu II-Mlu I fragment (pM7), have been constructed. An additional recombinant plasmid was constructed in which the Bgl II-Ava II fragment of the protamine gene containing the entire protamine promoter but missing the protamine coding region was cloned into pBR322 between the Xho II 1666 and Hind III sites (pP5). For in vitro transcription, a HeLa cell lysate system was prepared and the RNA transcription products, after glyoxalation, were electrophoretically analyzed on 5% polyacrylamide gels. In constructing pM8 the DNA sequence between the tk promoter and the cap site was present while in pM7 it was deleted. Similar multiple transcripts were seen in both cases, indicating that the region between the promoter and the cap site has no effect upon transcription in vitro. The multiple transcripts appear to be due to the presence of a cryptic promoter in the complementary strand of the protamine gene. The activity of this cryptic promoter has been confirmed by comparison of the transcription of plasmid pP5, in which the protamine mRNA coding region has been deleted, with a previously described plasmid, pJBRP (Jankowski JM and Dixon GH (1984) Can. J. Biochem. Cell. Biol. 62, 291-300), containing the intact protamine gene.

  14. Heterozygosity level and its relationship with genetic variability mechanisms in beans

    Directory of Open Access Journals (Sweden)

    Rita Carolina de Melo

    Full Text Available ABSTRACT Heterozygosity is an extremely important resource in early breeding programs using autogamous plants because it is usually associated with the presence of genetic variability. Induced mutation and artificial hybridization can increase distinctly the proportion of loci in heterozygosis. This study aimed to compare segregating and mutant populations and relate the mechanisms used to generate variability with their respective heterozygosity levels tested. The treatments mutant populations (M2, M3, M4, M5, M6 and M7, segregating populations (F4, F5 and F6 and lines (BRS Pérola and IPR Uirapuru were evaluated by multivariate analysis and compared by orthogonal contrasts. The canonical discriminant analysis revealed which response variables contributed to differentiate the treatments assessed. All orthogonal contrasts involving the mutant populations showed significant differences, except the contrast between M2 vs. M3, M4, M5, M6, M7. The orthogonal contrast between the mutant and segregating populations denotes a significant variation in the interest in genetic breeding. The traits stem diameter (1.41 and number of legumes per plant (2.72 showed the highest canonical weight in this contrast. Conversely, number of grains per plant (-3.58 approached the mutant and segregating populations. No significant difference was observed in the linear comparison of means F5 vs. F6. The traits are fixed early in the segregant populations, unlike the mutant populations. Comparatively, induced mutation provides more loci in heterozygosis than artificial hybridization. Selection pressure should vary according to the variability creation mechanism used at the beginning of the breeding program.

  15. Joint inversion of high resolution S-wave velocity structure underneath North China Basin (United States)

    Yang, C.; Li, G.; Niu, F.


    North China basin is one of earthquake prone areas in China. Many devastating earthquakes occurred in the last century and before, such as the 1937 M7.0 Heze Earthquake in Shandong province, the 1966 M7.2 Xingtai Earthquake and 1976 Tangshan Earthquake in Hebei province. Knowing the structure of the sediment cover is of great importance to predict strong ground motion caused by earthquakes. Unconsolidated sediments are loose materials, ranging from clay to sand to gravel. Earthquakes can liquefy unconsolidated sediments, thus knowing the distribution and thickness of the unconsolidated sediments has significant implication in seismic hazard analysis of the area. Quantitative estimates of the amount of extension of the North China basin is important to understand the thinning and evolution of the eastern North China craton and the underlying mechanism. In principle, the amount of lithospheric stretching can be estimated from sediment and crustal thickness. Therefore an accurate estimate of the sediment and crustal thickness of the area is also important in understanding regional tectonics. In this study, we jointly invert the Rayleigh wave phase-velocity dispersion and Z/H ratio data to construct a 3-D S-wave velocity model beneath North China area. We use 4-year ambient noise data recorded from 249 temporary stations, and 139 earthquake events to extract Rayleigh wave Z/H ratios. The Z/H ratios obtained from ambient noise data and earthquake data show a good agreement within the overlapped periods. The phase velocity dispersion curve was estimated from the same ambient noise data. The preliminary result shows a relatively low Z/H ratio and low velocity anomaly at the shallow part of sediment basins.

  16. Monitoring shallow resistivity changes prior to the 12 May 2008 M 8.0 Wenchuan earthquake on the Longmen Shan tectonic zone, China (United States)

    Lu, Jun; Xie, Tao; Li, Mei; Wang, Yali; Ren, Yuexia; Gao, Shude; Wang, Lanwei; Zhao, Jialiu


    An active source measurement of shallow resistivity using fixed-electrode quasi-Schlumberger arrays has been conducted at Pixian, Jiangyou and Wudu stations on the Longmen Shan tectonic zone in western China, with the hope of detecting earthquake-associated changes. For the duration of the monitoring experiment, a gradual decrease of apparent resistivity of up to 6.7% several years prior to the 12 May 2008 M 8.0 Wenchuan earthquake had been recorded clearly at Pixian station, approximately 35 km from the epicenter. The change of apparent resistivity was monitored with a fixed Schlumberger array of AB/MN spacings of 736 m/226 m in the direction of N57.5°E, giving precisions in measured daily averages of 0.16% or less. A coseismic resistivity drop of up to 5.3% was observed at Jiangyou station, using a Schlumberger array of AB/MN spacings of 710 m/90 m in the direction of N10°E. No fluctuation of resistivity was detected at Wudu station at the time of the Wenchuan mainshock. While the focus of this paper is on monitoring or tracking resistivity variations prior to, during, and after the Wenchuan earthquake, we also aim to compare resistivity records of the Wenchuan earthquake to those of the M 7.8 Tangshan and M 7.2 Songpan earthquakes of 1976. Attempts to explain the observed resistivity variations have been made. The results show that the resistivity variations observed at all three stations are in approximate agreement with resistivity-stress behavior deduced from in situ experiments, focal mechanisms, a simplified dynamical model, static stress analyses, and field investigations from along the Longmen Shan fault zone.

  17. A Full-Wave Seismic Tomography for the Crustal Structure in the Metropolitan Beijing Region (United States)

    Sun, A.; Zhao, L.; Chen, Q.


    The greater Beijing metropolitan region is located in an old cratonic block in northeast China with complex geology and several large historic earthquakes, such as the Sanhe-Pinggu earthquake (~M8.0) in 1679, the Xingtai earthquake (M7.2) in 1966, and the Tangshan earthquake (M7.8) in 1976. To enhance our understanding of the crustal structure and the seismotectonics under this region, we conduct a full-wave three-dimensional (3D) tomographic study of this region using the waveforms recorded by the newly established Beijing metropolitan digital seismic network. Since the Beijing network was put into operation in October 2001, there have been 89 local earthquakes of magnitude 3.0 and above. From these, we selected 23 events of magnitude 3.2 and above and obtained their waveform records at 50 stations within our area of interest. The types of instruments at these stations include broadband, short-period and very broadband. First-motion focal mechanisms were determined for these events. We used a regional 3D model obtained by seismic reflection surveys as the reference model and calculated the synthetic seismograms by the finite-difference method. In this first attempt at finite- frequency tomography for the Beijing region, we focus on the variation of the P-wave speed using the first- arriving P waves. We measure the frequency-dependent traveltime anomalies of the P waves by the cross- correlation between observed and synthetic P waveforms within several discrete frequency bands between 20-sec and 5-sec periods. The sensitivity or Frechet kernels of these measurements for the perturbations in P-wave speed were computed by the same finite-difference method. We will present the preliminary result in our full-wave seismic tomography for the Beijing region.

  18. Clustered and transient earthquake sequences in mid-continents (United States)

    Liu, M.; Stein, S. A.; Wang, H.; Luo, G.


    Earthquakes result from sudden release of strain energy on faults. On plate boundary faults, strain energy is constantly accumulating from steady and relatively rapid relative plate motion, so large earthquakes continue to occur so long as motion continues on the boundary. In contrast, such steady accumulation of stain energy does not occur on faults in mid-continents, because the far-field tectonic loading is not steadily distributed between faults, and because stress perturbations from complex fault interactions and other stress triggers can be significant relative to the slow tectonic stressing. Consequently, mid-continental earthquakes are often temporally clustered and transient, and spatially migrating. This behavior is well illustrated by large earthquakes in North China in the past two millennia, during which no single large earthquakes repeated on the same fault segments, but moment release between large fault systems was complementary. Slow tectonic loading in mid-continents also causes long aftershock sequences. We show that the recent small earthquakes in the Tangshan region of North China are aftershocks of the 1976 Tangshan earthquake (M 7.5), rather than indicators of a new phase of seismic activity in North China, as many fear. Understanding the transient behavior of mid-continental earthquakes has important implications for assessing earthquake hazards. The sequence of large earthquakes in the New Madrid Seismic Zone (NMSZ) in central US, which includes a cluster of M~7 events in 1811-1812 and perhaps a few similar ones in the past millennium, is likely a transient process, releasing previously accumulated elastic strain on recently activated faults. If so, this earthquake sequence will eventually end. Using simple analysis and numerical modeling, we show that the large NMSZ earthquakes may be ending now or in the near future.

  19. Induced seismicity hazard and risk by enhanced geothermal systems: an expert elicitation approach (United States)

    Trutnevyte, Evelina; Azevedo, Inês L.


    Induced seismicity is a concern for multiple geoenergy applications, including low-carbon enhanced geothermal systems (EGS). We present the results of an international expert elicitation (n = 14) on EGS induced seismicity hazard and risk. Using a hypothetical scenario of an EGS plant and its geological context, we show that expert best-guess estimates of annualized exceedance probabilities of an M ≥ 3 event range from 0.2%-95% during reservoir stimulation and 0.2%-100% during operation. Best-guess annualized exceedance probabilities of M ≥ 5 event span from 0.002%-2% during stimulation and 0.003%-3% during operation. Assuming that tectonic M7 events could occur, some experts do not exclude induced (triggered) events of up to M7 too. If an induced M = 3 event happens at 5 km depth beneath a town with 10 000 inhabitants, most experts estimate a 50% probability that the loss is contained within 500 000 USD without any injuries or fatalities. In the case of an induced M = 5 event, there is 50% chance that the loss is below 50 million USD with the most-likely outcome of 50 injuries and one fatality or none. As we observe a vast diversity in quantitative expert judgements and underlying mental models, we conclude with implications for induced seismicity risk governance. That is, we suggest documenting individual expert judgements in induced seismicity elicitations before proceeding to consensual judgements, to convene larger expert panels in order not to cherry-pick the experts, and to aim for multi-organization multi-model assessments of EGS induced seismicity hazard and risk.

  20. Compaction of Aquifer at Different Depths: Observations from a Vertical GPS Array in the Coastal Center of the University of Houston, Texas (United States)

    Lee, D.; Kearns, T.; Yang, L.; Wang, G.


    Houston and the surrounding Harris County have experienced the detrimental effects of subsidence even prior to World War II, to the extent that the land along Galveston Bay had sunk as much as 20 feet since 1906. One dramatic example is the Brownwood subdivision, a coastal community in Baytown where continuous flooding due to subsidence forced the area to be deemed unlivable and consequently abandoned. Thus, Houston's changes in groundwater and compaction of its aquifers are of relatively high concern to those in the public (infrastructure), private (oil & gas), and international (Port of Houston Authority) sectors. One of the key questions related to the subsidence issue in Houston area is what are the contributions of sediments at different depths, and what particularly is the contribution from shallow sediments? To address these questions, University of Houston has installed a vertical GPS array in the UH Coastal Center in March 2014. The GPS array includes four permanent GPS stations with the antenna pole foundations anchored at different depths below ground surface (-10 m, -7m, -4m, 0 m). A special, double-pipe GPS antenna monument was designed for GPS stations with the array. This project was funded by an NSF grant and a UH internal grant. Five groundwater wells with the depths ranging from 2 m to 100 m below the ground surface were also installed at the UH Coastal Center site. This study will investigate continuous GPS and groundwater level measurements (March-November, 2014) at the UHCC site. It is expected that the GPS array will provide total information on subsidence as well as compaction of aquifers within different depth ranges (0 to -4m, -4 to -7 m, -7 to -10m, and below -10 m). Correlation of land subsidence and groundwater fluctuation will also be investigated.

  1. The winds regime of surface in the Colombian coffee area

    International Nuclear Information System (INIS)

    Orlando Guzman Martinez; Lucia Gomez Gomez


    The characteristics of the address and gust of wind of the surface winds have been studied in 15 stations of the Colombian coffee area. It was found that the relief plays an important paper in the wind circulation so that during the day (7 a.m. - 7 p.m.) these they blow of the low sector toward the mountain and at night (7 p.m. - 7 a.m.) this situation is invested, that which is consistent with the characteristic pattern of circulation valley-mountain of the mountainous regions. For this fact, in most of the analyzed places a single day and night dominant address that it takes the orientation in that it is the respective hydrographic basin. It was not observed that the Alisios winds of the northeast and southeast modify the address settled down by the local circulation (valley-mountain) on the other hand a remarkable increase of the gust of wind was appreciated in July and August in the Florida and Ospina, stations located to the south of the country, as direct consequence of the Alisios of the southeast. The daily gust of wind in most of the studied places is low and it doesn't exceed of the 10 km/h, reason why it can consider that the Colombian coffee area is free of important damages for the action of the wind. Nevertheless, in some stations as Alban, Maracay and Paraguaicito the daily maximum gust of wind can surpass the 30 km/h and in occasions to cause damage mechanic to cultivations of high behavior and not well anchored facilities

  2. Evaluation of teleoperated surgical robots in an enclosed undersea environment. (United States)

    Doarn, Charles R; Anvari, Mehran; Low, Thomas; Broderick, Timothy J


    The ability to support surgical care in an extreme environment is a significant issue for both military medicine and space medicine. Telemanipulation systems, those that can be remotely operated from a distant site, have been used extensively by the National Aeronautics and Space Administration (NASA) for a number of years. These systems, often called telerobots, have successfully been applied to surgical interventions. A further extension is to operate these robotic systems over data communication networks where robotic slave and master are separated by a great distance. NASA utilizes the National Oceanographic and Atmospheric Administration (NOAA) Aquarius underwater habitat as an analog environment for research and technology evaluation missions, known as NASA Extreme Environment Mission Operations (NEEMO). Three NEEMO missions have provided an opportunity to evaluate teleoperated surgical robotics by astronauts and surgeons. Three robotic systems were deployed to the habitat for evaluation during NEEMO 7, 9, and 12. These systems were linked via a telecommunications link to various sites for remote manipulation. Researchers in the habitat conducted a variety of tests to evaluate performance and applicability in extreme environments. Over three different NEEMO missions, components of the Automated Endoscopic System for Optimal Positioning (AESOP), the M7 Surgical System, and the RAVEN were deployed and evaluated. A number of factors were evaluated, including communication latency and semiautonomous functions. The M7 was modified to permit a remote surgeon the ability to insert a needle into simulated tissue with ultrasound guidance, resulting in the world's first semi-autonomous supervisory-controlled medical task. The deployment and operation of teleoperated surgical systems and semi-autonomous, supervisory-controlled tasks were successfully conducted.

  3. Influence of LOD variations on seismic energy release (United States)

    Riguzzi, F.; Krumm, F.; Wang, K.; Kiszely, M.; Varga, P.


    Tidal friction causes significant time variations of geodynamical parameters, among them geometrical flattening. The axial despinning of the Earth due to tidal friction through the change of flattening generates incremental meridional and azimuthal stresses. The stress pattern in an incompressible elastic upper mantle and crust is symmetric to the equator and has its inflection points at the critical latitude close to ±45°. Consequently the distribution of seismic energy released by strong, shallow focus earthquakes should have also sharp maxima at this latitude. To investigate the influence of length of day (LOD) variations on earthquake activity an earthquake catalogue of strongest seismic events (M>7.0) was completed for the period 1900-2007. It is shown with the use of this catalogue that for the studied time-interval the catalogue is complete and consists of the seismic events responsible for more than 90% of released seismic energy. Study of the catalogue for earthquakes M>7.0 shows that the seismic energy discharged by the strongest seismic events has significant maxima at ±45°, what renders probably that the seismic activity of our planet is influenced by an external component, i.e. by the tidal friction, which acts through the variation of the hydrostatic figure of the Earth caused by it. Distribution along the latitude of earthquake numbers and energies was investigated also for the case of global linear tectonic structures, such as mid ocean ridges and subduction zones. It can be shown that the number of the shallow focus shocks has a repartition along the latitude similar to the distribution of the linear tectonic structures. This means that the position of foci of seismic events is mainly controlled by the tectonic activity.

  4. Effective Beginning Handwriting Instruction: Multi-modal, Consistent Format for 2 Years, and Linked to Spelling and Composing (United States)

    Wolf, Beverly; Abbott, Robert D.; Berninger, Virginia W.


    In Study 1, the treatment group (N = 33 first graders, M = 6 years 10 months, 16 girls) received Slingerland multi-modal (auditory, visual, tactile, motor through hand, and motor through mouth) manuscript (unjoined) handwriting instruction embedded in systematic spelling, reading, and composing lessons; and the control group (N =16 first graders, M = 7 years 1 month, 7 girls) received manuscript handwriting instruction not systematically related to the other literacy activities. ANOVA showed both groups improved on automatic alphabet writing from memory; but ANCOVA with the automatic alphabet writing task as covariate showed that the treatment group improved significantly more than control group from the second to ninth month of first grade on dictated spelling and recognition of word-specific spellings among phonological foils. In Study 2 new groups received either a second year of manuscript (N = 29, M = 7 years 8 months, 16 girls) or introduction to cursive (joined) instruction in second grade (N = 24, M = 8 years 0 months, 11 girls) embedded in the Slingerland literacy program. ANCOVA with automatic alphabet writing as covariate showed that those who received a second year of manuscript handwriting instruction improved more on sustained handwriting over 30, 60, and 90 seconds than those who had had only one year of manuscript instruction; both groups improved in spelling and composing from the second to ninth month of second grade. Results are discussed in reference to mastering one handwriting format before introducing another format at a higher grade level and always embedding handwriting instruction in writing and reading instruction aimed at all levels of language. PMID:28190930

  5. The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs. (United States)

    Wallace, Adam; Filbin, Megan E; Veo, Bethany; McFarland, Craig; Stepinski, Janusz; Jankowska-Anyszka, Marzena; Darzynkiewicz, Edward; Davis, Richard E


    Eukaryotic mRNA translation begins with recruitment of the 40S ribosome complex to the mRNA 5' end through the eIF4F initiation complex binding to the 5' m(7)G-mRNA cap. Spliced leader (SL) RNA trans splicing adds a trimethylguanosine (TMG) cap and a sequence, the SL, to the 5' end of mRNAs. Efficient translation of TMG-capped mRNAs in nematodes requires the SL sequence. Here we define a core set of nucleotides and a stem-loop within the 22-nucleotide nematode SL that stimulate translation of mRNAs with a TMG cap. The structure and core nucleotides are conserved in other nematode SLs and correspond to regions of SL1 required for early Caenorhabditis elegans development. These SL elements do not facilitate translation of m(7)G-capped RNAs in nematodes or TMG-capped mRNAs in mammalian or plant translation systems. Similar stem-loop structures in phylogenetically diverse SLs are predicted. We show that the nematode eukaryotic translation initiation factor 4E/G (eIF4E/G) complex enables efficient translation of the TMG-SL RNAs in diverse in vitro translation systems. TMG-capped mRNA translation is determined by eIF4E/G interaction with the cap and the SL RNA, although the SL does not increase the affinity of eIF4E/G for capped RNA. These results suggest that the mRNA 5' untranslated region (UTR) can play a positive and novel role in translation initiation through interaction with the eIF4E/G complex in nematodes and raise the issue of whether eIF4E/G-RNA interactions play a role in the translation of other eukaryotic mRNAs.

  6. The Nematode Eukaryotic Translation Initiation Factor 4E/G Complex Works with a trans-Spliced Leader Stem-Loop To Enable Efficient Translation of Trimethylguanosine-Capped RNAs ▿ † (United States)

    Wallace, Adam; Filbin, Megan E.; Veo, Bethany; McFarland, Craig; Stepinski, Janusz; Jankowska-Anyszka, Marzena; Darzynkiewicz, Edward; Davis, Richard E.


    Eukaryotic mRNA translation begins with recruitment of the 40S ribosome complex to the mRNA 5′ end through the eIF4F initiation complex binding to the 5′ m7G-mRNA cap. Spliced leader (SL) RNA trans splicing adds a trimethylguanosine (TMG) cap and a sequence, the SL, to the 5′ end of mRNAs. Efficient translation of TMG-capped mRNAs in nematodes requires the SL sequence. Here we define a core set of nucleotides and a stem-loop within the 22-nucleotide nematode SL that stimulate translation of mRNAs with a TMG cap. The structure and core nucleotides are conserved in other nematode SLs and correspond to regions of SL1 required for early Caenorhabditis elegans development. These SL elements do not facilitate translation of m7G-capped RNAs in nematodes or TMG-capped mRNAs in mammalian or plant translation systems. Similar stem-loop structures in phylogenetically diverse SLs are predicted. We show that the nematode eukaryotic translation initiation factor 4E/G (eIF4E/G) complex enables efficient translation of the TMG-SL RNAs in diverse in vitro translation systems. TMG-capped mRNA translation is determined by eIF4E/G interaction with the cap and the SL RNA, although the SL does not increase the affinity of eIF4E/G for capped RNA. These results suggest that the mRNA 5′ untranslated region (UTR) can play a positive and novel role in translation initiation through interaction with the eIF4E/G complex in nematodes and raise the issue of whether eIF4E/G-RNA interactions play a role in the translation of other eukaryotic mRNAs. PMID:20154140

  7. Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis (United States)

    Simoes-Barbosa, Augusto; Chakrabarti, Kausik; Pearson, Michael; Benarroch, Delphine; Shuman, Stewart; Johnson, Patricia J.


    The 2,2,7-trimethylguanosine caps of eukaryal snRNAs and snoRNA are formed by the enzyme Tgs1, which catalyzes sequential guanine-N2 methylations of m7G caps. Atypically, in the divergent unicellular eukaryote Trichomonas vaginalis, spliceosomal snRNAs lack a guanosine cap and the recombinant T. vaginalis trimethylguanosine synthase (TvTgs) produces only m2,7G in vitro. Here, we show by direct metabolic labeling that endogenous T. vaginalis RNAs contain m7G, m2,7G, and m2,2,7G caps. Immunodepletion of TvTgs from cell extracts and TvTgs add-back experiments demonstrate that TvTgs produces m2,7G and m2,2,7G caps. Expression of TvTgs in yeast tgs1Δ cells leads to the formation of m2,7G and m2,2,7G caps and complementation of the lethality of a tgs1Δ mud2Δ strain. Whereas TvTgs is present in the nucleus and cytosol of T. vaginalis cells, TMG-containing RNAs are localized primarily in the nucleolus. Molecular cloning of anti-TMG affinity-purified T. vaginalis RNAs identified 16 box H/ACA snoRNAs, which are implicated in guiding RNA pseudouridylation. The ensemble of new T. vaginalis H/ACA snoRNAs allowed us to predict and partially validate an extensive map of pseudouridines in T. vaginalis rRNA. PMID:22847815

  8. Seismo-Ionospheric Coupling as Intensified EIA Observed by Satellite Electron Density and GPS-TEC Data (United States)

    Ryu, K.; Jangsoo, C.; Kim, S. G.; Jeong, K. S.; Parrot, M.; Pulinets, S. A.; Oyama, K. I.


    Examples of intensified EIA features temporally and spatially related to large earthquakes observed by satellites and GPS-TEC are introduced. The precursory, concurrent, and ex-post enhancements of EIA represented by the equatorial electron density, which are thought to be related to the M8.7 Northern Sumatra earthquake of March 2005, the M8.0 Pisco earthquake of August 2007, and the M7.9 Wenchuan Earthquake of 12 May 2008, are shown with space weather condition. Based on the case studies, statistical analysis on the ionospheric electron density data measured by the Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions satellite (DEMETER) over a period of 2005-2010 was executed in order to investigate the correlation between seismic activity and equatorial plasma density variations. To simplify the analysis, three equatorial regions with frequent earthquakes were selected and then one-dimensional time series analysis between the daily seismic activity indices and the EIA intensity indices were performed for each region with excluding the possible effects from the geomagnetic and solar activity. The statistically significant values of the lagged cross-correlation function, particularly in the region with minimal effects of longitudinal asymmetry, indicate that some of the very large earthquakes with M > 7.0 in the low latitude region can accompany observable seismo-ionospheric coupling phenomena in the form of EIA enhancements, even though the seismic activity is not the most significant driver of the equatorial ionospheric evolution. The physical mechanisms of the seismo-ionospheric coupling to explain the observation and the possibility of earthquake prediction using the EIA intensity variation are discussed.

  9. Magnitude and Surface Rupture Length of Prehistoric Upper Crustal Earthquakes in the Puget Lowland, Washington State (United States)

    Sherrod, B. L.; Styron, R. H.


    Paleoseismic studies documented prehistoric earthquakes after the last glaciation ended 15 ka on 13 upper-crustal fault zones in the Cascadia fore arc. These fault zones are a consequence of north-directed fore arc block migration manifesting as a series of bedrock uplifts and intervening structural basins in the southern Salish Sea lowland between Vancouver, B.C. to the north and Olympia, WA to the south, and bounded on the east and west by the Cascade Mountains and Olympic Mountains, respectively. Our dataset uses published information and includes 27 earthquakes tabulated from observations of postglacial deformation at 63 sites. Stratigraphic offsets along faults consist of two types of measurements: 1) vertical separation of strata along faults observed in fault scarp excavations, and 2) estimates from coastal uplift and subsidence. We used probabilistic methods to estimate past rupture magnitudes and surface rupture length (SRL), applying empirical observations from modern earthquakes and point measurements from paleoseismic sites (Biasi and Weldon, 2006). Estimates of paleoearthquake magnitude ranged between M 6.5 and M 7.5. SRL estimates varied between 20 and 90 km. Paleoearthquakes on the Seattle fault zone and Saddle Mountain West fault about 1100 years ago were outliers in our analysis. Large offsets observed for these two earthquakes implies a M 7.8 and 200 km SRL, given the average observed ratio of slip/SRL in modern earthquakes. The actual mapped traces of these faults are less than 200km, implying these earthquakes had an unusually high static stress drop or, in the case of the Seattle fault, splay faults may have accentuated uplift in the hanging wall. Refined calculations incorporating fault area may change these magnitude and SRL estimates. Biasi, G.P., and Weldon, R.J., 2006, Estimating Surface Rupture Length and Magnitude of Paleoearthquakes from Point Measurements of Rupture Displacement: B. Seismol. Soc. Am., 96, 1612-1623.

  10. Study of nuclei by electron scattering

    International Nuclear Information System (INIS)

    Torizuka, Yoshiharu; Saito, Teijiro; Ito, Kohei; Terasawa, Tatsuo; Hosoyama, Kenji.


    It is urgently required to clarify the physical meaning of the quasi-elastic scattering associated with the background, in order to develop rapidly the study of giant resonance. The experimental works performed in the present term aimed at the synthetic understanding of both giant resonance and quasi-elastic scattering, and presented the possibility of the separability of giant resonance from quasi-elastic scattering. The object of this experiment was to measure higher order multi-pole moment of 51 V by using relatively high energy electron beam. Targets of chemically pure 51 V had thickness of 68.2 or 100.5 mg/cm 2 . The measurement was made at the position where scattering angle was 155 0 . The state of M7 can be well explained by the model with (fsub(7/2)) 3 coordination. This may be because the nuclei with stretched configuration such as 51 V do not have any contribution of orbital motion, but have the contribution of eigen magnetic moment to the highest multiplicity. States of M3 and M5 are a little complicated. Since in the experimental equipment used, the contribution of charge distribution was so large, that it was difficult to make the precision measurement of M3 and M5. In 51 V, however, it can be considered that M3 and M5 decreased by the contribution of 2Psub(3/2) and 1fsub(5/2). On the other hand, there is no contribution from these energy states to M7. (Tai, I.)

  11. Earth-Atmospheric Coupling Prior to Strong Earthquakes Analyzed by IR Remote Sensing Data (United States)

    Freund, F.; Ouzounov, D.


    Earth-atmosphere interactions during major earthquakes (M>5) are the subject of this study. A mechanism has recently been proposed to account for the appearance of hole-type electronic charge carriers in rocks subjected to transient stress [Freund, 2000]. If such charge carriers are activated in the crust prior to large earthquakes, the predictable consequences are: injection of currents into the rocks, low frequency electromagnetic emission, changes in ground potentials, corona discharges with attendant light emission from high points at the surface of the Earth, and possibly an enhanced emission in the 8-12 μ m region similar to the thermal emission observed during laboratory rock deformation experiments [Geng et al., 1999]. Using data from MODIS (Moderate Resolution Imaging Spectroradiometer) and ASTER (Advanced Spaceborne Thermal Emission & Reflection radiometer) onboard NASA's TERRA satellite launched in Dec. 1999 we have begun analyzing vertical atmospheric profiles, land surface and kinetic temperatures. We looked for correlations between atmospheric dynamics and solid Earth processes prior to the Jan. 13, 2001 earthquake in El Salvador (M=7.6) and the Jan. 26, 2001 Gujarat earth-quake in India (M=7.7). With MODIS covering the entire Earth every 1-2 days in 36 wavelength bands (20 visible and 16 infrared) at different spatial resolutions (250 m, 500 m, and 1 km) we find evidence for a thermal anomaly pattern related to the pre-seismic activity. We also find evidence for changes in the aerosol content and atmospheric instability parameters, possibly due to changes in the ground potential that cause ion emission and lead to the formation of a thin near-ground aerosol layer. We analyze the aerosol content, atmospheric pressure, moisture profile and lifted index.

  12. Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques. (United States)

    Uckoo, Ram M; Jayaprakasha, Guddadarangavvanahally K; Balasubramaniam, V M; Patil, Bhimanagouda S


    Grapefruits (Citrus paradisi Macfad) contain several phytochemicals known to have health maintaining properties. Due to the consumer's interest in obtaining high levels of these phytochemicals, it is important to understand the changes in their levels by common household processing techniques. Therefore, mature Texas "Rio Red" grapefruits were processed by some of the common household processing practices such as blending, juicing, and hand squeezing techniques and analyzed for their phytochemical content by high performance liquid chromatography (HPLC). Results suggest that grapefruit juice processed by blending had significantly (P levels of flavonoids (narirutin, naringin, hesperidin, neohesperidin, didymin, and poncirin) and limonin compared to juicing and hand squeezing. No significant variation in their content was noticed in the juice processed by juicing and hand squeezing. Ascorbic acid and citric acid were significantly (P processed by juicing and blending, respectively. Furthermore, hand squeezed fruit juice had significantly higher contents of dihydroxybergamottin (DHB) than juice processed by juicing and blending. Bergamottin and 5-methoxy-7 gernoxycoumarin (5-M-7-GC) were significantly higher in blended juice compared to juicing and hand squeezing. Therefore, consuming grapefruit juice processed by blending may provide higher levels of health beneficial phytochemicals such as naringin, narirutin, and poncirin. In contrast, juice processed by hand squeezing and juicing provides lower levels of limonin, bergamottin, and 5-M-7-GC. These results suggest that, processing techniques significantly influence the levels of phytochemicals and blending is a better technique for obtaining higher levels of health beneficial phytochemicals from grapefruits. Practical Application:  Blending, squeezing, and juicing are common household processing techniques used for obtaining fresh grapefruit juice. Understanding the levels of health beneficial phytochemicals

  13. Development of an UPLC-MS/MS method for quantification of Avitinib (AC0010) and its five metabolites in human cerebrospinal fluid: Application to a study of the blood-brain barrier penetration rate of non-small cell lung cancer patients. (United States)

    Wang, Weicong; Zheng, Xin; Wang, Hanping; Wang, Lu; Jiang, Ji; Hu, Pei


    Avitinib (AC0010) is a mutant-selective epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI), designed to be a targeted therapeutic agent for non-small cell lung cancer (NSCLC) patients harboring EGFR active and T790M resistant mutations. A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the determination of Avitinib and its five metabolites (M1, M2, M4, M7, MII-6) in human cerebrospinal fluid (CSF). The samples were purified by protein precipitation and separated on a BEH C 18 column (2.1×50mm, 1.7μm). Electrospray ionization (ESI) in positive ion mode and multiple reaction monitoring (MRM) were used to monitor the ion transitions at m/z 488/257, 474/403, 504/487, 434/377, 490/405, 476/391. The results indicated that the method had excellent sensitivity and specificity. The linear range covered from 0.05 to 50ng/mL for Avitinib, M1, M4, M7, and MII-6, and from 0.01 to 10ng/mL for M2. Intra-day and inter-day precisions (in terms of% RSD) were all <15% and the accuracies (in terms of% RE) were within the range of ±15%. The lower limit of quantification (LLOQ), matrix effect, extraction recovery, stability and dilution integrity were also validated and satisfied with the criteria of validation. Finally, the method was successfully applied to a blood-brain barrier (BBB) penetration rate research of NSCLC patients after an oral administration of Avitinib. Copyright © 2017. Published by Elsevier B.V.

  14. Characterization of macromolecular baseline of human brain using metabolite cycled semi-LASER at 9.4T. (United States)

    Giapitzakis, Ioannis-Angelos; Avdievich, Nikolai; Henning, Anke


    Macromolecular resonances (MM) arise mainly from cytosolic proteins and overlap with metabolites, influencing metabolite quantification. Macromolecules can serve as valuable biomarkers for diseases and pathologies. The objectives of this study were to characterize MM at 9.4T in the human brain (occipital and left parietal lobe) and to describe the RF coil setup used for MM acquisition in the two regions. An adiabatic inversion pulse was optimised for metabolite nulling at 9.4T using double inversion recovery and was combined for the first time with metabolite cycled (MC) semi-LASER and appropriate coil configuration. MM spectra (seven volunteers) from two brain locations were averaged and smoothed creating MM templates, which were then parametrized using simulated Voigt-shaped lines within LCModel. Quantification was performed on individual data sets, including corrections for different tissue composition and the T 1 and T 2 relaxation of water. Our coil configuration method resulted in efficient B1+ (>30 T/√kW) for both brain regions. The 15 MM components were detected and quantified in MM baselines of the two brain areas. No significant differences in concentration levels of MM between different regions were found. Two new MM peaks were reported (M7 & M8). Double inversion, which was combined with MC semi-LASER, enabled the acquisition of high spectral resolution MM spectra for both brain regions at 9.4T. The 15 MM components were detected and quantified. Two new MM peaks were reported for the first time (M7 & M8) and preliminarily assigned to β-methylene protons of aspartyl-groups. Magn Reson Med 80:462-473, 2018. © 2018 International Society for Magnetic Resonance in Medicine. © 2018 International Society for Magnetic Resonance in Medicine.

  15. Cytogenetic analysis and chromosomal characteristics of the polymorphic 18S rDNA of Haliotis discus hannai from Fujian, China.

    Directory of Open Access Journals (Sweden)

    Haishan Wang

    Full Text Available We report on novel chromosomal characteristics of Haliotis discus hannai from a breeding population at Fujian, China. The karyotypes of H. discus hannai we obtained from an abalone farm include a common type 2n = 36 = 10M + 8SM (82% and two rare types 2n = 36 = 11M + 7SM (14% and 2n = 36 = 10M + 7SM + 1ST (4%. The results of silver staining showed that the NORs of H. discus hannai were usually located terminally on the long arms of chromosome pairs 14 and 17, NORs were also sometimes located terminally on the short arms of other chromosomes, either metacentric or submetacentric pairs. The number of Ag-nucleoli ranged from 2 to 8, and the mean number was 3.61 ± 0.93. Among the scored interphase cells, 41% had 3 detectable nucleoli and 37% had 4 nucleoli. The 18S rDNA FISH result is the first report of the location of 18S rDNA genes in H. discus hannai. The 18S rDNA locations were highly polymorphic in this species. Copies of the gene were observed in the terminal of long or/and short arms of submetacentric or/and metacentric chromosomes. Using FISH with probe for vertebrate-like telomeric sequences (CCCTAA3 displayed positive green FITC signals at telomere regions of all analyzed chromosome types. We found about 7% of chromosomes had breaks in prophase. A special form of nucleolus not previously described from H. discus hannai was observed in some interphase cells. It consists of many small silver-stained nucleoli gathered together to form a larger nucleolus and may correspond to prenucleolar bodies.


    International Nuclear Information System (INIS)

    Giodini, S.; Pierini, D.; Finoguenov, A.; Pratt, G. W.; Boehringer, H.; Leauthaud, A.; Guzzo, L.; Aussel, H.; Bolzonella, M.; Capak, P.; Elvis, M.; Hasinger, G.; Ilbert, O.; Kartaltepe, J. S.; Koekemoer, A. M.; Lilly, S. J.; Massey, R.; Rhodes, J.; Salvato, M.; McCracken, H. J.


    We investigate if the discrepancy between estimates of the total baryon mass fraction obtained from observations of the cosmic microwave background (CMB) and of galaxy groups/clusters persists when a large sample of groups is considered. To this purpose, 91 candidate X-ray groups/poor clusters at redshift 0.1 ≤ z ≤ 1 are selected from the COSMOS 2 deg 2 survey, based only on their X-ray luminosity and extent. This sample is complemented by 27 nearby clusters with a robust, analogous determination of the total and stellar mass inside R 500 . The total sample of 118 groups and clusters with z ≤ 1 spans a range in M 500 of ∼10 13 -10 15 M sun . We find that the stellar mass fraction associated with galaxies at R 500 decreases with increasing total mass as M -0.37±0.04 500 , independent of redshift. Estimating the total gas mass fraction from a recently derived, high-quality scaling relation, the total baryon mass fraction (f stars+gas 500 = f stars 500 + f gas 500 ) is found to increase by ∼25%, when M 500 increases from (M) = 5 x 10 13 M sun to (M) = 7 x 10 14 M sun . After consideration of a plausible contribution due to intracluster light (11%-22% of the total stellar mass) and gas depletion through the hierarchical assembly process (10% of the gas mass), the estimated values of the total baryon mass fraction are still lower than the latest CMB measure of the same quantity (WMAP5), at a significance level of 3.3σ for groups of (M) = 5 x 10 13 M sun . The discrepancy decreases toward higher total masses, such that it is 1σ at (M) = 7 x 10 14 M sun . We discuss this result in terms of nongravitational processes such as feedback and filamentary heating.

  17. Using surface creep rate to infer fraction locked for sections of the San Andreas fault system in northern California from alignment array and GPS data (United States)

    Lienkaemper, James J.; McFarland, Forrest S.; Simpson, Robert W.; Caskey, S. John


    Surface creep rate, observed along five branches of the dextral San Andreas fault system in northern California, varies considerably from one section to the next, indicating that so too may the depth at which the faults are locked. We model locking on 29 fault sections using each section’s mean long‐term creep rate and the consensus values of fault width and geologic slip rate. Surface creep rate observations from 111 short‐range alignment and trilateration arrays and 48 near‐fault, Global Positioning System station pairs are used to estimate depth of creep, assuming an elastic half‐space model and adjusting depth of creep iteratively by trial and error to match the creep observations along fault sections. Fault sections are delineated either by geometric discontinuities between them or by distinctly different creeping behaviors. We remove transient rate changes associated with five large (M≥5.5) regional earthquakes. Estimates of fraction locked, the ratio of moment accumulation rate to loading rate, on each section of the fault system provide a uniform means to inform source parameters relevant to seismic‐hazard assessment. From its mean creep rates, we infer the main branch (the San Andreas fault) ranges from only 20%±10% locked on its central creeping section to 99%–100% on the north coast. From mean accumulation rates, we infer that four urban faults appear to have accumulated enough seismic moment to produce major earthquakes: the northern Calaveras (M 6.8), Hayward (M 6.8), Rodgers Creek (M 7.1), and Green Valley (M 7.1). The latter three faults are nearing or past their mean recurrence interval.

  18. Outcomes From AAS Hack Day at the 227th AAS Meeting (United States)

    Kohler, Susanna


    paper, Ruth is seeking contributions of one-minute audio recordings.RadioFree LST: Radio observers dont care when the Sun is up, but they do care if their astronomical objects of interest are above the horizon. Demitri Muna (Ohio State) and Amanda Kepley (NRAO) created a calculator which uses local sidereal time (LST) to determine when sources rise and set based on the position of the observatory and the coordinates of the target..@demitrimuna @aakepley are creating a LST calculator for radio telescopes. #radiofreelst #hackaas astrobites (@astrobites) January 8, 2016Hidden Killer Detective: The Kepler spacecraft has enabled many discoveries related to exoplanets and stars. But now that K2 is observing in the ecliptic plane, it should also find asteroids. Geert Barentsen (NASA Ames), Tom Barclay (NASA Ames), Meg Schwamb (ASIAA), and Brooke Simmons (UC San Diego) created a new crowd-sourced Zooniverse project so anyone can help search for moving objects that may be asteroids.Expanding Astronomy on Tap: This casual science pub night, started in 2013, is now a regular event in seven cities worldwide. Jeff Silverman (UT Austin) created a Launch Manifesto and guide for bringing Astronomy on Tap to your own city. If youre interested, fill out their survey to get more information.The Arceli Project: Arceli is publishing online astronomy content. A team led by ScienceBetter and Kelle Cruz (CUNY) including Daina Bouquin (Harvard CfA), Aram Zucker-Scharff, Lars Holm Nielsen (CERN), Jonathan Sick (LSST), Chris Erdmann (Harvard CfA), and Meredith Rawls (NMSU) worked on getting each component of Arceli to talk to the others. Eventually, Arceli will accept submissions of informal scholarly contentlike blog postswhich will become archived and citable just like traditional papers.Special Dark: Leonidas Moustakas (JPL/Caltech) and Tonima Ananna (Yale) hosted a special session at this years AAS meeting all about dark matter. During hack day, they began a

  19. Evaluating earthquake hazards in the Los Angeles region; an earth-science perspective (United States)

    Ziony, Joseph I.


    Potentially destructive earthquakes are inevitable in the Los Angeles region of California, but hazards prediction can provide a basis for reducing damage and loss. This volume identifies the principal geologically controlled earthquake hazards of the region (surface faulting, strong shaking, ground failure, and tsunamis), summarizes methods for characterizing their extent and severity, and suggests opportunities for their reduction. Two systems of active faults generate earthquakes in the Los Angeles region: northwest-trending, chiefly horizontal-slip faults, such as the San Andreas, and west-trending, chiefly vertical-slip faults, such as those of the Transverse Ranges. Faults in these two systems have produced more than 40 damaging earthquakes since 1800. Ninety-five faults have slipped in late Quaternary time (approximately the past 750,000 yr) and are judged capable of generating future moderate to large earthquakes and displacing the ground surface. Average rates of late Quaternary slip or separation along these faults provide an index of their relative activity. The San Andreas and San Jacinto faults have slip rates measured in tens of millimeters per year, but most other faults have rates of about 1 mm/yr or less. Intermediate rates of as much as 6 mm/yr characterize a belt of Transverse Ranges faults that extends from near Santa Barbara to near San Bernardino. The dimensions of late Quaternary faults provide a basis for estimating the maximum sizes of likely future earthquakes in the Los Angeles region: moment magnitude .(M) 8 for the San Andreas, M 7 for the other northwest-trending elements of that fault system, and M 7.5 for the Transverse Ranges faults. Geologic and seismologic evidence along these faults, however, suggests that, for planning and designing noncritical facilities, appropriate sizes would be M 8 for the San Andreas, M 7 for the San Jacinto, M 6.5 for other northwest-trending faults, and M 6.5 to 7 for the Transverse Ranges faults. The

  20. Tsunami Numerical Simulation for Hypothetical Giant or Great Earthquakes along the Izu-Bonin Trench (United States)

    Harada, T.; Ishibashi, K.; Satake, K.


    We performed tsunami numerical simulations from various giant/great fault models along the Izu-Bonin trench in order to see the behavior of tsunamis originated in this region and to examine the recurrence pattern of great interplate earthquakes along the Nankai trough off southwest Japan. As a result, large tsunami heights are expected in the Ryukyu Islands and on the Pacific coasts of Kyushu, Shikoku and western Honshu. The computed large tsunami heights support the hypothesis that the 1605 Keicho Nankai earthquake was not a tsunami earthquake along the Nankai trough but a giant or great earthquake along the Izu-Bonin trench (Ishibashi and Harada, 2013, SSJ Fall Meeting abstract). The Izu-Bonin subduction zone has been regarded as so-called 'Mariana-type subduction zone' where M>7 interplate earthquakes do not occur inherently. However, since several M>7 outer-rise earthquakes have occurred in this region and the largest slip of the 2011 Tohoku earthquake (M9.0) took place on the shallow plate interface where the strain accumulation had considered to be a little, a possibility of M>8.5 earthquakes in this region may not be negligible. The latest M 7.4 outer-rise earthquake off the Bonin Islands on Dec. 22, 2010 produced small tsunamis on the Pacific coast of Japan except for the Tohoku and Hokkaido districts and a zone of abnormal seismic intensity in the Kanto and Tohoku districts. Ishibashi and Harada (2013) proposed a working hypothesis that the 1605 Keicho earthquake which is considered a great tsunami earthquake along the Nankai trough was a giant/great earthquake along the Izu-Bonin trench based on the similarity of the distributions of ground shaking and tsunami of this event and the 2010 Bonin earthquake. In this study, in order to examine the behavior of tsunamis from giant/great earthquakes along the Izu-Bonin trench and check the Ishibashi and Harada's hypothesis, we performed tsunami numerical simulations from fault models along the Izu-Bonin trench

  1. Crustal architecture of the eastern margin of Japan Sea: back-arc basin opening and contraction (United States)

    No, T.; Sato, T.; Takahashi, N.; Kodaira, S.; Kaneda, Y.; Ishiyama, T.; Sato, H.


    Although large earthquakes such as the 1964 Niigata earthquake (M 7.5), 1983 Nihonkai-Chubu earthquake (M 7.8), and 1993 Hokkaido Nansei-Oki earthquake (M 7.8) have caused large amounts of damage to the eastern margin of the Japan Sea, a substantial number of seismic studies have been conducted for the seismogenic zone on the Pacific Ocean side of Japan. In addition, the detail of the source fault model for the eastern margin of the Japan Sea is not well defined for all cases. This highlights the need for further studies to investigate seismic imaging. Therefore, we have collaborated with other Japanese research institutions for a project titled "Priority Investigations of Strain Concentration Areas" (which is funded by Special Coordination Funds for Promoting Science and Technology, Japan). This project has conducted seismic surveys from 2009 to 2012 using the deep-sea research vessel, Kairei, from the Japan Agency for Marine-Earth Science and Technology. There is a strain concentration area in the eastern part of the survey area (Okamura et al., 1995). The western part of the survey area includes the Yamato Basin and Japan Basin. It is very important to study the crustal structure in the seismotectonic studies of the eastern margin of the Japan Sea. We conducted a marine seismic survey by using a multichannel seismic (MCS) system and ocean bottom seismographs (OBSs) along the eastern margin of the Japan Sea. Seismic data were acquired along 42 lines with a total length of approximately 9,000 km. The following results were obtained from seismic imaging. On the basis of the results of the MCS imaging, active reverse faults and folds were observed in the margin of the Toyama Trough; however, the sedimentary layers in the trough were flat. In the sedimentary layers and crusts of the Sado Ridge, Mogami Trough, and source area of the 1964 Niigata earthquake located north of the Sado Island, greater deformation was observed. The deformation weakened toward the Yamato

  2. Defeating Earthquakes (United States)

    Stein, R. S.


    The 2004 M=9.2 Sumatra earthquake claimed what seemed an unfathomable 228,000 lives, although because of its size, we could at least assure ourselves that it was an extremely rare event. But in the short space of 8 years, the Sumatra quake no longer looks like an anomaly, and it is no longer even the worst disaster of the Century: 80,000 deaths in the 2005 M=7.6 Pakistan quake; 88,000 deaths in the 2008 M=7.9 Wenchuan, China quake; 316,000 deaths in the M=7.0 Haiti, quake. In each case, poor design and construction were unable to withstand the ferocity of the shaken earth. And this was compounded by inadequate rescue, medical care, and shelter. How could the toll continue to mount despite the advances in our understanding of quake risk? The world's population is flowing into megacities, and many of these migration magnets lie astride the plate boundaries. Caught between these opposing demographic and seismic forces are 50 cities of at least 3 million people threatened by large earthquakes, the targets of chance. What we know for certain is that no one will take protective measures unless they are convinced they are at risk. Furnishing that knowledge is the animating principle of the Global Earthquake Model, launched in 2009. At the very least, everyone should be able to learn what his or her risk is. At the very least, our community owes the world an estimate of that risk. So, first and foremost, GEM seeks to raise quake risk awareness. We have no illusions that maps or models raise awareness; instead, earthquakes do. But when a quake strikes, people need a credible place to go to answer the question, how vulnerable am I, and what can I do about it? The Global Earthquake Model is being built with GEM's new open source engine, OpenQuake. GEM is also assembling the global data sets without which we will never improve our understanding of where, how large, and how frequently earthquakes will strike, what impacts they will have, and how those impacts can be lessened by

  3. Re-examination of the original questionnaire documents for the 1944 Tonankai, 1945 Mikawa, and 1946 Nanaki earthquakes (United States)

    Harada, Tomoya; Satake, Kenji; Furumura, Takashi


    With the object of estimating seismic intensity, the Earthquakes Research Institute (ERI) of the University of Tokyo performed questionnaire surveys for the significant (destructive or large/great) earthquakes from 1943 to 1988 (Kayano, 1990, BERI). In these surveys, Kawasumi (1943)'s 12-class seismic intensity scale similar to the Modified Mercalli scale (MM-scale) was used. Survey results for earthquakes after 1950 were well investigated and published (e.g. Kayano and Komaki, 1977, BERI; Kayano and Sato, 1975, BERI), but the survey results for earthquakes in the 1940s have not been published and original documents of the surveys was missing. Recently, the original sheets of the surveys for the five earthquakes in the 1940s with more than 1,000 casualties were discovered in the ERI warehouse, although they are incomplete (Tsumura et al, 2010). They are from the 1943 Tottori (M 7.2), 1944 Tonankai (M 7.9), 1945 Mikawa (M 6.8), 1946 Nankai (M 8.0), and 1948 Fukui (M 7.1) earthquakes. In this study, we examined original questionnaire and summary sheets for the 1944 Tonankai, 1945 Mikawa, and 1946 Nanaki earthquakes, and estimated the distributions of seismic intensity, various kinds of damage, and human behaviors in detail. Numbers of the survey points for the 1944, 1945, and 1946 event are 287, 145, and 1,014, respectively. The numbers for the 1944 and 1945 earthquakes are much fewer than that of the 1946 event, because they occurred during the last years of World War II. The 1944 seismic intensities in the prefectures near the source region (Aichi, Mie, Shizuoka, and Gifu Pref.) tend to be high. However, the 1944 intensities are also high and damage is serious at the Suwa Lake shore in Nagano Pref. which is about 240 km far from the source region because seismic waves are amplified dramatically in the thick sediment in the Suwa Basin. Seismic intensities of the 1945 Mikawa earthquake near the source region in Aichi Pref. were very high (X-XI). However, the

  4. Primary genome scan to identify putative quantitative trait loci for feedlot growth rate, feed intake, and feed efficiency of beef cattle. (United States)

    Nkrumah, J D; Sherman, E L; Li, C; Marques, E; Crews, D H; Bartusiak, R; Murdoch, B; Wang, Z; Basarab, J A; Moore, S S


    Feed intake and feed efficiency of beef cattle are economically relevant traits. The study was conducted to identify QTL for feed intake and feed efficiency of beef cattle by using genotype information from 100 microsatellite markers and 355 SNP genotyped across 400 progeny of 20 Angus, Charolais, or Alberta Hybrid bulls. Traits analyzed include feedlot ADG, daily DMI, feed-to-gain ratio [F:G, which is the reciprocal of the efficiency of gain (G:F)], and residual feed intake (RFI). A mixed model with sire as random and QTL effects as fixed was used to generate an F-statistic profile across and within families for each trait along each chromosome, followed by empirical permutation tests to determine significance thresholds for QTL detection. Putative QTL for ADG (chromosome-wise P < 0.05) were detected across families on chromosomes 5 (130 cM), 6 (42 cM), 7 (84 cM), 11 (20 cM), 14 (74 cM), 16 (22 cM), 17 (9 cM), 18 (46 cM), 19 (53 cM), and 28 (23 cM). For DMI, putative QTL that exceeded the chromosome-wise P < 0.05 threshold were detected on chromosomes 1 (93 cM), 3 (123 cM), 15 (31 cM), 17 (81 cM), 18 (49 cM), 20 (56 cM), and 26 (69 cM) in the across-family analyses. Putative across-family QTL influencing F:G that exceeded the chromosome-wise P < 0.05 threshold were detected on chromosomes 3 (62 cM), 5 (129 cM), 7 (27 cM), 11 (16 cM), 16 (30 cM), 17 (81 cM), 22 (72 cM), 24 (55 cM), and 28 (24 cM). Putative QTL influencing RFI that exceeded the chromosome-wise P < 0.05 threshold were detected on chromosomes 1 (90 cM), 5 (129 cM), 7 (22 cM), 8 (80 cM), 12 (89 cM), 16 (41 cM), 17 (19 cM), and 26 (48 cM) in the across-family analyses. In addition, a total of 4, 6, 1, and 8 chromosomes showed suggestive evidence (chromosome-wise, P < 0.10) for putative ADG, DMI, F:G, and RFI QTL, respectively. Most of the QTL detected across families were also detected within families, although the locations across families were not necessarily the locations within families, which is

  5. Seismic imaging of North China: insight into intraplate volcanism and seismotectonics (United States)

    Zhao, D.


    We used seismic tomography to study the detailed three-dimensional (3-D) seismic velocity structure of the crust and mantle beneath North China for understanding the intraplate volcanism and seismotectonics of the Asian continent. Two active volcanoes, Changbai and Wudalianchi, exist in Northeast China and they have erupted several times in the last 1000 years. The origin of the active intraplate volcanoes is still unclear. Global tomography shows that the subducting Pacific slab becomes stagnant under NE Asia and strong low-velocity (low-V) anomalies exist in the upper mantle under the two volcanoes (Zhao, 2004). Recently we determined a 3-D P-wave velocity structure under the Changbai volcano using teleseismic data recorded by 19 portable seismic stations in NE China (Zhao et al., 2004). Our result shows a columnar low-V anomaly extending to 400 km depth and high-velocity anomalies in the mantle transition zone with deep-focus earthquakes of about 600 km depth. These results indicatie that the Changbai and Wudalianchi volcanoes are not hotspot like Hawaii but a kind of back-arc volcano related to the deep subduction and stagnancy of the Pacific slab under NE Asia. A detailed 3-D P-wave tomography of the crust and uppermost mantle under the Beijing region is determined by using local earthquake arrival times recorded by the newly installed Chinese Capital Seismic Network with 101 short-period seismic stations coving the region densely and uniformly (Huang and Zhao, 2004). The results show that large crustal earthquakes, such as the 1679 Sanhe earthquake (M 8.0) and the 1976 Tangshan earthquake (M 7.8), generally occurred in high-velocity areas in the upper to middle crust. In the lower crust to the uppermost mantle under the source zones of the large earthquakes, however, low-velocity and high-conductivity anomalies exist, which are considered to be associated with fluids. The fluids in the lower crust may cause the weakening of the seismogenic layer in the upper

  6. Gas and Dust Phenomena of Mega-earthquakes and the Cause (United States)

    Yue, Z.


    A mega-earthquake suddenly releases a large to extremely large amount of kinetic energy within a few tens to two hundreds seconds and over ten to hundreds kilometer distances in the Earth's crust and on ground surface. It also generates seismic waves that can be received globally and co-seismic ground damages such co-seismic ruptures and landslides. However, such vast, dramatic and devastating kinetic actions in the Earth's crustal rocks and on the ground soils cannot be known or predicted by people at few weeks, days, hours, or minutes before they are happening. Although seismologists can develop and use seismometers to report the locations and magnitudes of earthquakes within minutes of their occurrence, they cannot predict earthquakes at present. Therefore, damage earthquakes have caused and would continue to cause huge disasters, fatalities and injuries to our human beings. This problem may indicate that it is necessary to re-examine the cause of mega-earthquakes in addition to the conventional cause of active fault elastic rebounding. In the last ten years, many mega-earthquakes occurred in China and around the Pacific Ocean and caused many casualties to human beings and devastating disasters to environments. The author will give a brief review on the impacts of the mega-earthquakes happened in recent years. He will then present many gas and dust related phenomena associated with the sudden occurrences of these mega earthquakes. They include the 2001 Kunlunshan Earthquake M8.1, 2008 Wenchuan Earthquake M8.0 and the 2010 Yushu Earthquake M7.1 in China, the 2010 Haiti Earthquake M7.0, the 2010 Mexicali Earthquake M7.2, the 2010 Chile Earthquake M8.8, the 2011 Christchurch earthquake M6.3 and the 2011 Japan Earthquake M9.0 around the Pacific Ocean. He will discuss the cause of these gas and dust related phenomena. He will use these phenomena and their common cause to show that the earthquakes were caused the rapid migration and expansion of highly compressed and

  7. Influence of turbulence on the drop growth in warm clouds, Part I: comparison of numerically and experimentally determined collision kernels

    Directory of Open Access Journals (Sweden)

    Christoph Siewert


    Full Text Available This study deals with the comparison of numerically and experimentally determined collision kernels of water drops in air turbulence. The numerical and experimental setups are matched as closely as possible. However, due to the individual numerical and experimental restrictions, it could not be avoided that the turbulent kinetic energy dissipation rate of the measurement and the simulations differ. Direct numerical simulations (DNS are performed resulting in a very large database concerning geometric collision kernels with 1470 individual entries. Based on this database a fit function for the turbulent enhancement of the collision kernel is developed. In the experiments, the collision rates of large drops (radius >7.5μm$> 7.5\\,\\text{\\textmu{}m}$ are measured. These collision rates are compared with the developed fit, evaluated at the measurement conditions. Since the total collision rates match well for all occurring dissipation rates the distribution information of the fit could be used to enhance the statistical reliability and for the first time an experimental collision kernel could be constructed. In addition to the collision rates, the drop size distributions at three consecutive streamwise positions are measured. The drop size distributions contain mainly small drops (radius <7.5μm$< 7.5\\,\\text{\\textmu{}m}$. The measured evolution of the drop size distribution is confronted with model calculations based on the newly derived fit of the collision kernel. It turns out that the observed fast evolution of the drop size distribution can only be modeled if the collision kernel for small drops is drastically increased. A physical argument for this amplification is missing since for such small drops, neither DNSs nor experiments have been performed. For large drops, for which a good agreement of the collision rates was found in the DNS and the experiment, the time for the evolution of the spectrum in the wind tunnel is too short to draw

  8. The seismic cycles of large Romanian earthquake: The physical foundation, and the next large earthquake in Vrancea

    International Nuclear Information System (INIS)

    Purcaru, G.


    The occurrence patterns of large/great earthquakes at subduction zone interface and in-slab are complex in the space-time dynamics, and make even long-term forecasts very difficult. For some favourable cases where a predictive (empirical) law was found successful predictions were possible (eg. Aleutians, Kuriles, etc). For the large Romanian events (M > 6.7), occurring in the Vrancea seismic slab below 60 km, Purcaru (1974) first found the law of the occurrence time and magnitude: the law of 'quasicycles' and 'supercycles', for large and largest events (M > 7.25), respectively. The quantitative model of Purcaru with these seismic cycles has three time-bands (periods of large earthquakes)/century, discovered using the earthquake history (1100-1973) (however incomplete) of large Vrancea earthquakes for which M was initially estimated (Purcaru, 1974, 1979). Our long-term prediction model is essentially quasideterministic, it predicts uniquely the time and magnitude; since is not strict deterministic the forecasting is interval valued. It predicted the next large earthquake in 1980 in the 3rd time-band (1970-1990), and which occurred in 1977 (M7.1, M w 7.5). The prediction was successful, in long-term sense. We discuss the unpredicted events in 1986 and 1990. Since the laws are phenomenological, we give their physical foundation based on the large scale of rupture zone (RZ) and subscale of the rupture process (RP). First results show that: (1) the 1940 event (h=122 km) ruptured the lower part of the oceanic slab entirely along strike, and down dip, and similarly for 1977 but its upper part, (2) the RZ of 1977 and 1990 events overlap and the first asperity of 1977 event was rebroken in 1990. This shows the size of the events strongly depends on RZ, asperity size/strength and, thus on the failure stress level (FSL), but not on depth, (3) when FSL of high strength (HS) larger zones is critical largest events (eg. 1802, 1940) occur, thus explaining the supercyles (the 1940

  9. Calorimetric Study of Phase Transitions Involving Twist-Grain-Boundary TGB{A} and TGB{C} Phases (United States)

    Navailles, L.; Garland, C. W.; Nguyen, H. T.


    High-resolution calorimetry has been used to determine the heat capacity and latent heat associated with phase transitions in the homologous series of chiral liquid crystals nF_2BTFO_1M_7 [ 3-fluoro-4(1-methylheptyloxy)4'-(4''-alkoxy-2'', 3''-difluorobenzoyloxy)tolane] . These compounds exhibit smectic-C^* (SmC^*), twist-grain-boundary (TGBA for n=10, TGBC for n=11, 12) and cholesteric (N^*) phases. All the phase transitions are first order with small to moderate latent heats. There is a large rounded excess heat capacity peak in the N^* phase that is consistent with the predicted appearance of short-range TGB order (chiral line liquid character). This is analogous to the development of an Abrikosov flux vortex liquid in type-II superconductors. Both the n=11 and 12 homologs exhibit two closely spaced transitions in the region where a single TGBC - N^* transition was expected. This suggests the existence of two thermodynamically distinct TGBC phases. Des exprériences de calorimétrie haute résolution ont été réalisées pour déterminer les chaleurs spécifiques et les chaleurs latentes associées aux transitions de phase des homologues de la série crystal liquide nF_2BTFO_1M_7: 3-fluoro-4[1-methyl-heptyloxy]4'-(4''-alcoxy-2'', 3''-difluorobenzoyloxy)tolanes. Ces produits présentent la phase smectique C^* (SmC^*), les phases à torsion par joint de grain (TGBA pour n=10 et TGBC pour n=11, 12) et la phase cholestérique (N^*). Toutes les transitions de phase sont du premier ordre. La chaleur latente associée à ces transitions est faibles ou modérée. Nous observons, dans la phase N^*, un grand pic arrondi qui est en accord avec les prédictions de l'apparition d'un ordre TGB à courte distance (liquide de ligne de dislocation). Ce phénomène est l'analogue du liquide de vortex dans les supraconducteurs de type II. Les composés n=11 et 12 présentent, dans la région où nous attendions une transition TGBC - N^* unique, deux transitions sur un très faible


    International Nuclear Information System (INIS)

    Morgan, Dylan P.; West, Andrew A.; Dhital, Saurav; Fuchs, Miriam; Garcés, Ane; Catalán, Silvia; Silvestri, Nicole M.


    We present a study of close white dwarf and M dwarf (WD+dM) binary systems and examine the effect that a close companion has on the magnetic field generation in M dwarfs. We use a base sample of 1602 white dwarf main-sequence binaries from Rebassa-Mansergas et al. to develop a set of color cuts in GALEX, SDSS, UKIDSS, and 2MASS color space. Then using the SDSS Data Release 8 spectroscopic database, we construct a sample of 1756 WD+dM high-quality pairs from our color cuts and previous catalogs. We separate the individual WD and dM from each spectrum using an iterative technique that compares the WD and dM components to best-fit templates. Using the absolute height above the Galactic plane as a proxy for age, and the Hα emission line as an indicator for magnetic activity, we investigate the age-activity relation for our sample for spectral types ≤ M7. Our results show that early-type M dwarfs (≤M4) in close binary systems are more likely to be active and have longer activity lifetimes compared to their field counterparts. However, at a spectral type of M5 (just past the onset of full convection in M dwarfs), the activity fraction and lifetimes of WD+dM binary systems become more comparable to that of the field M dwarfs. One of the implications of having a close binary companion is presumed to be increased stellar rotation through disk disruption, tidal effects, or angular momentum exchange. Thus, we interpret the similarity in activity behavior between late-type dMs in WD+dM pairs and late-type field dMs to be due to a decrease in sensitivity in close binary companions (or stellar rotation), which has implications for the nature of magnetic activity in fully convective stars. Using the WD components of the pairs, we find WD cooling ages to use as an additional constraint on the age-activity relation for our sample. We find that, on average, active early-type dMs tend to be younger and that active late-type dMs span a much broader age regime making them

  11. Historical reconstruction of oil and gas spills during moderate and strong earthquakes and related geochemical surveys in Southern Apennines (United States)

    Sciarra, Alessandra; Cantucci, Barbara; Ferrari, Graziano; Pizzino, Luca; Quattrocchi, Fedora


    The aim of this study is to contribute to the assessment of natural hazards in a seismically active area of southern Italy through the joint analysis of historical sources and fluid geochemistry. In particular, our studies have been focalized in the Val d'Agri basin, in the Apennines extensional belt, since it hosts the largest oilfield in onshore Europe and normal-fault systems with high seismogenic potential (up to M7). The work was organized into three main themes: 1) literature search aimed at identifying fluid emissions during previous moderate-strong earthquakes; 2) consultation of local and national archives to identify historic local place names correlated to natural fluids emissions; 3) geochemical sampling of groundwater and gas issuing at surface, identified on the basis of the bibliographic sources. A reasoned reading of written documents and available historical data was performed. Moreover, we reworked information reported in historical catalogues, referred to liquid and gas hydrocarbon leakages occurred during seismic events of the past (in a range of magnitude from 5 to 7) in the Southern Apennines (with a particular focus on the Val d'Agri). Special attention was given to the phenomena of geochemical emissions related to major historical earthquakes that took place in the area, most notably that of 16 December 1857 (M = 7). A careful analysis of the Robert Mallet's report, a complete work aimed at describing the social impact and the effects on the environment produced by this earthquake through illustrated maps and diagrams, included several hundred monoscopic and stereoscopic photographs, was done. From archival sources (at national and/or local administrations), "sensitive" sites to the onset of leakage of liquid and gaseous hydrocarbons in the past were identified. A soil-gas survey (22 gas concentrations and flux measurements) and 35 groundwater samplings were carried out in specific sites recognized through the above studies. From a

  12. New tomographic images of P- , S- wave velocity and Q on the Philippine Sea Slab beneath Tokyo: Implication to seismotectonics and seismic hazard in the Tokyo metropolitan region (United States)

    Hirata, Naoshi; Sakai, Shin'ichi; Nakagawa, Shigeki; Panayotopoulos, Yannis; Ishikawa, Masahiro; Sato, Hiroshi; Kasahara, Keiji; Kimura, Hisanor; Honda, Ryou


    The Central Disaster Management Council of Japan estimates the next great M7+ earthquake in the Tokyo metropolitan region will cause 11,000 fatalities and 112 trillion yen (1 trillion US) economic loss at worst case if it occur beneath northern Tokyo bay with M7.3. However, the estimate is based on a source fault model by conventional studies about the PSP geometry. To evaluate seismic hazard due to the great quake we need to clarify the geometry of PSP and also the Pacific palate (PAP) that subducs beneath PSP. We identify those plates with use of seismic tomography and available deep seismic reflection profiling and borehole data in southern Kanto area. We deployed about 300 seismic stations in the greater Tokyo urban region under the Special Project for Earthquake Disaster Mitigation in Tokyo Metropolitan Area. We obtain clear P- and S- wave velocity (Vp and Vs) and Q tomograms which show a clear image of PSP and PAP. A depth to the top of PSP, 20 to 30 kilometer beneath northern part of Tokyo bay, is about 10 km shallower than previous estimates based on the distribution of seismicity (Ishida, 1992). This shallower plate geometry changes estimations of strong ground motion for seismic hazards analysis within the Tokyo region. Based on elastic wave velocities of rocks and minerals, we interpreted the tomographic images as petrologic images. Tomographic images revealed the presence of two stepwise velocity increase of the top layer of the subducting PSP slab. Rock velocity data reveals that subducting PSP crust transforms from blueschists to amphibolites at depth of 30km and amphibolites to eclogites at depth of 50km, which suggest that dehydration reactions occurs in subducting crust of basaltic compositions during prograde metamorphism and water is released from the subducting PSP crust. Tomograms show evidence for a low-velocity zone (LVZ) beneath the area just north of Tokyo bay. A Q tomogram show a low Q zone in PSP slab. We interpret the LVZ as a

  13. Multi-Parameter Observation and Detection of Pre-Earthquake Signals in Seismically Active Areas (United States)

    Ouzounov, D.; Pulinets, S.; Parrot, M.; Liu, J. Y.; Hattori, K.; Kafatos, M.; Taylor, P.


    The recent large earthquakes (M9.0 Tohoku, 03/2011; M7.0 Haiti, 01/2010; M6.7 L Aquila, 04/2008; and M7.9 Wenchuan 05/2008) have renewed interest in pre-anomalous seismic signals associated with them. Recent workshops (DEMETER 2006, 2011 and VESTO 2009 ) have shown that there were precursory atmospheric /ionospheric signals observed in space prior to these events. Our initial results indicate that no single pre-earthquake observation (seismic, magnetic field, electric field, thermal infrared [TIR], or GPS/TEC) can provide a consistent and successful global scale early warning. This is most likely due to complexity and chaotic nature of earthquakes and the limitation in existing ground (temporal/spatial) and global satellite observations. In this study we analyze preseismic temporal and spatial variations (gas/radon counting rate, atmospheric temperature and humidity change, long-wave radiation transitions and ionospheric electron density/plasma variations) which we propose occur before the onset of major earthquakes:. We propose an Integrated Space -- Terrestrial Framework (ISTF), as a different approach for revealing pre-earthquake phenomena in seismically active areas. ISTF is a sensor web of a coordinated observation infrastructure employing multiple sensors that are distributed on one or more platforms; data from satellite sensors (Terra, Aqua, POES, DEMETER and others) and ground observations, e.g., Global Positioning System, Total Electron Content (GPS/TEC). As a theoretical guide we use the Lithosphere-Atmosphere-Ionosphere Coupling (LAIC) model to explain the generation of multiple earthquake precursors. Using our methodology, we evaluated retrospectively the signals preceding the most devastated earthquakes during 2005-2011. We observed a correlation between both atmospheric and ionospheric anomalies preceding most of these earthquakes. The second phase of our validation include systematic retrospective analysis for more than 100 major earthquakes (M>5

  14. Potential biosignatures in super-Earth atmospheres II. Photochemical responses. (United States)

    Grenfell, J L; Gebauer, S; Godolt, M; Palczynski, K; Rauer, H; Stock, J; von Paris, P; Lehmann, R; Selsis, F


    Spectral characterization of super-Earth atmospheres for planets orbiting in the habitable zone of M dwarf stars is a key focus in exoplanet science. A central challenge is to understand and predict the expected spectral signals of atmospheric biosignatures (species associated with life). Our work applies a global-mean radiative-convective-photochemical column model assuming a planet with an Earth-like biomass and planetary development. We investigated planets with gravities of 1g and 3g and a surface pressure of 1 bar around central stars with spectral classes from M0 to M7. The spectral signals of the calculated planetary scenarios have been presented by in an earlier work by Rauer and colleagues. The main motivation of the present work is to perform a deeper analysis of the chemical processes in the planetary atmospheres. We apply a diagnostic tool, the Pathway Analysis Program, to shed light on the photochemical pathways that form and destroy biosignature species. Ozone is a potential biosignature for complex life. An important result of our analysis is a shift in the ozone photochemistry from mainly Chapman production (which dominates in Earth's stratosphere) to smog-dominated ozone production for planets in the habitable zone of cooler (M5-M7)-class dwarf stars. This result is associated with a lower energy flux in the UVB wavelength range from the central star, hence slower planetary atmospheric photolysis of molecular oxygen, which slows the Chapman ozone production. This is important for future atmospheric characterization missions because it provides an indication of different chemical environments that can lead to very different responses of ozone, for example, cosmic rays. Nitrous oxide, a biosignature for simple bacterial life, is favored for low stratospheric UV conditions, that is, on planets orbiting cooler stars. Transport of this species from its surface source to the stratosphere where it is destroyed can also be a key process. Comparing 1g with

  15. Quantifying Heuristic Bias: Anchoring, Availability, and Representativeness. (United States)

    Richie, Megan; Josephson, S Andrew


    significance for students (Version A, M = 7.28, SD = 3.46; Version B, M = 5.82, SD = 3.22), t(153) = 2.67, p = .008, and residents (Version A, M = 7.19, SD = 3.24; Version B, M = 5.56, SD = 2.72), t(77) = 2.32, p = .02, but not attendings. Authors developed an instrument to isolate and quantify bias produced by the availability and representativeness heuristics, and illustrated the utility of their instrument by demonstrating decreased heuristic bias within medical contexts at higher training levels.

  16. Factors influencing the missed nursing care in patients from a private hospital. (United States)

    Hernández-Cruz, Raúl; Moreno-Monsiváis, María Guadalupe; Cheverría-Rivera, Sofía; Díaz-Oviedo, Aracely


    to determine the factors that influence the missed nursing care in hospitalized patients. descriptive correlational study developed at a private hospital in Mexico. To identify the missed nursing care and related factors, the MISSCARE survey was used, which measures the care missed and associated factors. The care missed and the factors were grouped in global and dimension rates. For the analysis, descriptive statistics, Spearman's correlation and simple linear regression were used. Approval for the study was obtained from the ethics committee. the participants were 71 nurses from emergency, intensive care and inpatient services. The global missed care index corresponded to M=7.45 (SD=10.74); the highest missed care index was found in the dimension basic care interventions (M=13.02, SD=17.60). The main factor contributing to the care missed was human resources (M=56.13, SD=21.38). The factors related to the care missed were human resources (rs=0.408, precursos humanos (M=56,13, DE=21,38). Os fatores relacionados ao cuidado omitido foram os recursos humanos (rs=0,408, precursos humanos; com base nos resultados deste estudo pode-se fortalecer a continuidade do cuidado de enfermagem. determinar los factores que influyen en el cuidado de enfermería perdido en pacientes hospitalizados. estudio descriptivo correlacional, se realizó en un hospital privado de México. Para identificar el cuidado perdido y factores relacionados se utilizó el instrumento MISSCARE que mide el cuidado perdido y los factores asociados. El cuidado perdido y los factores se agruparon en índices globales y por dimensiones. Para el análisis se utilizó estadística descriptiva, correlación de Spearman y regresión lineal simple. El estudio fue aprobado por el comité de ética. participaron 71 enfermeras de los servicios de urgencias, terapia intensiva y hospitalización. El índice global de cuidado perdido mostró una M=7,45 (DE=10,74); el índice con mayor cuidado perdido correspondió a

  17. Calibration and validation of earthquake catastrophe models. Case study: Impact Forecasting Earthquake Model for Algeria (United States)

    Trendafiloski, G.; Gaspa Rebull, O.; Ewing, C.; Podlaha, A.; Magee, B.


    Calibration and validation are crucial steps in the production of the catastrophe models for the insurance industry in order to assure the model's reliability and to quantify its uncertainty. Calibration is needed in all components of model development including hazard and vulnerability. Validation is required to ensure that the losses calculated by the model match those observed in past events and which could happen in future. Impact Forecasting, the catastrophe modelling development centre of excellence within Aon Benfield, has recently launched its earthquake model for Algeria as a part of the earthquake model for the Maghreb region. The earthquake model went through a detailed calibration process including: (1) the seismic intensity attenuation model by use of macroseismic observations and maps from past earthquakes in Algeria; (2) calculation of the country-specific vulnerability modifiers by use of past damage observations in the country. The use of Benouar, 1994 ground motion prediction relationship was proven as the most appropriate for our model. Calculation of the regional vulnerability modifiers for the country led to 10% to 40% larger vulnerability indexes for different building types compared to average European indexes. The country specific damage models also included aggregate damage models for residential, commercial and industrial properties considering the description of the buildings stock given by World Housing Encyclopaedia and the local rebuilding cost factors equal to 10% for damage grade 1, 20% for damage grade 2, 35% for damage grade 3, 75% for damage grade 4 and 100% for damage grade 5. The damage grades comply with the European Macroseismic Scale (EMS-1998). The model was validated by use of "as-if" historical scenario simulations of three past earthquake events in Algeria M6.8 2003 Boumerdes, M7.3 1980 El-Asnam and M7.3 1856 Djidjelli earthquake. The calculated return periods of the losses for client market portfolio align with the

  18. Assessment of rice yield loss due to exposure to ozone pollution in Southern Vietnam

    Energy Technology Data Exchange (ETDEWEB)

    Danh, Ngo Thanh; Huy, Lai Nguyen; Oanh, Nguyen Thi Kim, E-mail:


    The study domain covered the Eastern region of Southern of Vietnam that includes Ho Chi Minh City (HCMC) and five other provinces. Rice production in the domain accounted for 13% of the national total with three crop cycles per year. We assessed ozone (O{sub 3}) induced rice production loss in the domain for 2010 using simulated hourly surface O{sub 3} concentrations (WRF/CAMx; 4 km resolution). Simulated O{sub 3} was higher in January–February (largely overlaps the first crop) and September–December (third crop), and lower in March–June (second crop). Spatially, O{sub 3} was higher in downwind locations of HCMC and were comparable with observed data. Relative yield loss (RYL) was assessed for each crop over the respective growing period (105 days) using three metrics: AOT40, M7 and flux-based O{sub 3} dose of POD{sub 10}. Higher RYL was estimated for the downwind of HCMC. Overall, the rice production loss due to O{sub 3} exposure in the study domain in 2010 was the highest for the first crop (up to 25,800 metric tons), the second highest for the third crop (up to 21,500 tons) and the least for the second crop (up to 6800 tons). The low RYL obtained for the second crop by POD{sub 10} may be due to the use of a high threshold value (Y = 10 nmol m{sup −2} s{sup −1}). Linear regression between non-null radiation POD{sub 0} and POD{sub 10} had similar slopes for the first and third crop when POD{sub 0} was higher and very low slope for the second crop when POD{sub 0} was low. The results of this study can be used for the rice crop planning to avoid the period of potential high RYL due to O{sub 3} exposure. - Highlights: • Simulated O{sub 3} was used to assess rice yield loss in a domain of Southern Vietnam. • Exposure metrics of AOT40, M7, POD{sub 0} and POD{sub 10} were considered. • POD{sub 10} gave the highest rice production loss. • Higher production loss was found downwind of Ho Chi Minh City.

  19. Ground Motion Prediction Trends For Eastern North America Based on the Next Generation Attenuation East Ground Motion Database (United States)

    Cramer, C. H.; Kutliroff, J.; Dangkua, D.


    A five-year Next Generation Attenuation (NGA) East project to develop new ground motion prediction equations for stable continental regions (SCRs), including eastern North America (ENA), has begun at the Pacific Earthquake Engineering Research (PEER) Center funded by the Nuclear Regulatory Commission (NRC), the U.S. Geological Survey (USGS), the Electric Power Research Institute (EPRI), and the Department of Energy (DOE). The initial effort focused on database design and collection of appropriate M>4 ENA broadband and accelerograph records to populate the database. Ongoing work has focused on adding records from smaller ENA earthquakes and from other SCRs such as Europe, Australia, and India. Currently, over 6500 horizontal and vertical component records from 60 ENA earthquakes have been collected and prepared (instrument response removed, filtering to acceptable-signal band, determining peak and spectral parameter values, quality assurance, etc.) for the database. Geologic Survey of Canada (GSC) strong motion recordings, previously not available, have also been added to the NGA East database. The additional earthquakes increase the number of ground motion recordings in the 10 - 100 km range, particularly from the 2008 M5.2 Mt. Carmel, IL event, and the 2005 M4.7 Riviere du Loup and 2010 M5.0 Val des Bois earthquakes in Quebec, Canada. The goal is to complete the ENA database and make it available in 2011 followed by a SCR database in 2012. Comparisons of ground motion observations from four recent M5 ENA earthquakes with current ENA ground motion prediction equations (GMPEs) suggest that current GMPEs, as a group, reasonably agree with M5 observations at short periods, particularly at distances less than 200 km. However, at one second, current GMPEs over predict M5 ground motion observations. The 2001 M7.6 Bhuj, India, earthquake provides some constraint at large magnitudes, as geology and regional attenuation is analogous to ENA. Cramer and Kumar, 2003, have

  20. Hazus® estimated annualized earthquake losses for the United States (United States)

    Jaiswal, Kishor; Bausch, Doug; Rozelle, Jesse; Holub, John; McGowan, Sean


    Large earthquakes can cause social and economic disruption that can be unprecedented to any given community, and the full recovery from these impacts may or may not always be achievable. In the United States (U.S.), the 1994 M6.7 Northridge earthquake in California remains the third costliest disaster in U.S. history; and it was one of the most expensive disasters for the federal government. Internationally, earthquakes in the last decade alone have claimed tens of thousands of lives and caused hundreds of billions of dollars of economic impact throughout the globe (~90 billion U.S. dollars (USD) from 2008 M7.9 Wenchuan China, ~20 billion USD from 2010 M8.8 Maule earthquake in Chile, ~220 billion USD from 2011 M9.0 Tohoku Japan earthquake, ~25 billion USD from 2011 M6.3 Christchurch New Zealand, and ~22 billion USD from 2016 M7.0 Kumamoto Japan). Recent earthquakes show a pattern of steadily increasing damages and losses that are primarily due to three key factors: (1) significant growth in earthquake-prone urban areas, (2) vulnerability of the older building stock, including poorly engineered non-ductile concrete buildings, and (3) an increased interdependency in terms of supply and demand for the businesses that operate among different parts of the world. In the United States, earthquake risk continues to grow with increased exposure of population and development even though the earthquake hazard has remained relatively stable except for the regions of induced seismic activity. Understanding the seismic hazard requires studying earthquake characteristics and locales in which they occur, while understanding the risk requires an assessment of the potential damage from earthquake shaking to the built environment and to the welfare of people—especially in high-risk areas. Estimating the varying degree of earthquake risk throughout the United States is critical for informed decision-making on mitigation policies, priorities, strategies, and funding levels in the

  1. Biological activity determination of I-BSP, a potent MMP 2 inhibitor, and its 123I tracer synthesis

    International Nuclear Information System (INIS)

    Oltenfreiter, R.; Staelens, L.; Slegers, G.; Lejeune, A.; Frankenne, F.; Dierckx, R.A.


    Aim: Matrix metalloproteinases (MMPs) are a family of at least 18 secreted and membrane-bound zinc endopeptidases. Collectively they function in the degradation of extracellular matrix proteins and play an important role in both normal and pathological tissue remodelling. Increased MMP activity is detected in a wide range of cancers and seems to be correlated to their invasive and metastatic potential. MMPs thus seem an attractive target for both diagnostic (SPECT tracer) and therapeutic purposes. Therefore, we synthesised a 123 I-labelled MMP 2 inhibitor and evaluated it in vitro. Materials and methods: The 123 I-labelled compound was synthesised by a Cu-assisted nucleophilic non-isotopic exchange starting from Br-BSP. After reaction, the mixture was purified by HPLC. IC 50 values were obtained by in vitro enzyme assays. A 1:1 mix between non-radiolabelled inhibitor (concentration range: 300 nM - 0.05 nM) and enzymes (MMP2, cMT1-MMP, cMT3-MMP) was incubated for 15 minutes at 37 0 C. The fluorescent substrate (Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2) was added and the increase of fluorescence versus time, due to the hydrolysis of substrate, was measured (GEMINI-XS, λ exc = 328 nm and λ em = 393nm). Initial velocities were calculated for different concentrations of inhibitor and the IC 50 values were then determined. Results: Radiochemical yield was 30% ±3%. Radiochemical purity was >95%. IC 50 values for inhibition of MMP2, cMT3-MMP and cMT1-MMP were 0.5 nM, 7.1 nM and 16.9 nM respectively. Conclusion: 123 I-BSP was synthesised with 30% ±3% yield. After HPLC the radiochemical purity was >95%. In vitro enzyme assays of I-BSP showed an inhibition of MMP2, cMT3-MMP and cMT1-MMP in the low nM range (0.5 nM, 7.1 nM and 16.9 nM respectively). In vivo studies (biodistribution, metabolizing) in mice will be performed in the near future

  2. Seismotectonics of Bhutan: Evidence for segmentation of the Eastern Himalayas and link to foreland deformation (United States)

    Diehl, Tobias; Singer, Julia; Hetényi, György; Grujic, Djordje; Clinton, John; Giardini, Domenico; Kissling, Edi; Gansser Working Group


    The instrumental record of Bhutan is characterized by a lower seismicity compared to other parts of the Himalayan arc. To understand this low activity and its impact on the seismic hazard, a seismic network was installed in Bhutan for 22 months between 2013 and 2014. Recorded seismicity, earthquake moment tensors and local earthquake tomography reveal along-strike variations in structure and crustal deformation regime. A thickened crust imaged in western Bhutan suggests lateral differences in stresses on the Main Himalayan Thrust (MHT), potentially affecting the interseismic coupling and deformation regime. Sikkim, western Bhutan and its foreland are characterized by strike-slip faulting in the Indian basement. Strain is particularly localized along a NW-SE striking mid-crustal fault zone reaching from Chungthang in northeast Sikkim to Dhubri at the northwestern edge of the Shillong Plateau in the foreland. The dextral Dhubri-Chungthang fault zone (DCF) causes segmentation of the Indian basement and the MHT between eastern Nepal and western Bhutan and connects the deformation front of the Himalaya with the Shillong Plateau by forming the western boundary of the Shillong block. The Kopili fault, the proposed eastern boundary of this block, appears to be a diffuse zone of mid-crustal seismicity in the foreland. In eastern Bhutan we image a seismogenic, flat portion of the MHT, which might be either related to a partially creeping segment or to increased background seismicity originating from the 2009 MW 6.1 earthquake. In western-central Bhutan clusters of micro-earthquakes at the front of the High-Himalayas indicate the presence of a mid-crustal ramp and stress buildup on a fully coupled MHT. The area bounded by the DCF in the west and the seismogenic MHT in the east has the potential for M7-8 earthquakes in Bhutan. Similarly, the DCF has the potential to host M7 earthquakes as documented by the 2011 Sikkim and the 1930 Dhubri earthquakes, which were potentially


    International Nuclear Information System (INIS)

    Sales, Dinalva A.; Pastoriza, M. G.; Riffel, R.


    We study the polycyclic aromatic hydrocarbon (PAH) bands, ionic emission lines, and mid-infrared continuum properties in a sample of 171 emission line galaxies taken from the literature plus 15 new active galactic nucleus (AGN) Spitzer spectra. We normalize the spectra at λ = 23 μm and grouped them according to the type of nuclear activity. The continuum shape steeply rises for longer wavelengths and can be fitted with a warm blackbody distribution of T ∼ 150-300 K. The brightest PAH spectral bands (6.2, 7.7, 8.6, 11.3, and 12.7 μm) and the forbidden emission lines of [Si II] 34.8 μm, [Ar II] 6.9 μm, [S III] 18.7 and 33.4 μm were detected in all the starbursts and in ∼80% of the Seyfert 2. Taking under consideration only the PAH bands at 7.7 μm, 11.3 μm, and 12.7 μm, we find that they are present in ∼80% of the Seyfert 1, while only half of this type of activity show the 6.2 μm and 8.6 μm PAH bands. The observed intensity ratios for neutral and ionized PAHs (6.2 μm/7.7 μm x 11.3 μm/7.7 μm) were compared to theoretical intensity ratios, showing that AGNs have higher ionization fraction and larger PAH molecules (≥180 carbon atoms) than SB galaxies. The ratio between the ionized (7.7 μm) and the neutral PAH bands (8.6 μm and 11.3 μm) are distributed over different ranges for AGNs and SB galaxies, suggesting that these ratios could depend on the ionization fraction, as well as on the hardness of the radiation field. The ratio between the 7.7 μm and 11.3 μm bands is nearly constant with the increase of [Ne III]15.5 μm/[Ne II] 12.8 μm, indicating that the fraction of ionized to neutral PAH bands does not depend on the hardness of the radiation field. The equivalent width of both PAH features show the same dependence (strongly decreasing) with [Ne III]/[Ne II], suggesting that the PAH molecules, emitting either ionized (7.7 μm) or neutral (11.3 μm) bands, may be destroyed with the increase of the hardness of the radiation field.

  4. Monitoring of the spatio-temporal change in the interplate coupling at northeastern Japan subduction zone based on the spatial gradients of surface velocity field (United States)

    Iinuma, Takeshi


    A monitoring method to grasp the spatio-temporal change in the interplate coupling in a subduction zone based on the spatial gradients of surface displacement rate fields is proposed. I estimated the spatio-temporal change in the interplate coupling along the plate boundary in northeastern (NE) Japan by applying the proposed method to the surface displacement rates based on global positioning system observations. The gradient of the surface velocities is calculated in each swath configured along the direction normal to the Japan Trench for time windows such as 0.5, 1, 2, 3 and 5 yr being shifted by one week during the period of 1997-2016. The gradient of the horizontal velocities is negative and has a large magnitude when the interplate coupling at the shallow part (less than approximately 50 km in depth) beneath the profile is strong, and the sign of the gradient of the vertical velocity is sensitive to the existence of the coupling at the deep part (greater than approximately 50 km in depth). The trench-parallel variation of the spatial gradients of a displacement rate field clearly corresponds to the trench-parallel variation of the amplitude of the interplate coupling on the plate interface, as well as the rupture areas of previous interplate earthquakes. Temporal changes in the trench-parallel variation of the spatial gradient of the displacement rate correspond to the strengthening or weakening of the interplate coupling. We can monitor the temporal change in the interplate coupling state by calculating the spatial gradients of the surface displacement rate field to some extent without performing inversion analyses with applying certain constraint conditions that sometimes cause over- and/or underestimation at areas of limited spatial resolution far from the observation network. The results of the calculation confirm known interplate events in the NE Japan subduction zone, such as the post-seismic slip of the 2003 M8.0 Tokachi-oki and 2005 M7.2 Miyagi

  5. Re-investigation of slip rate along the southern part of the Sumatran Fault Zone using SuMo GPS network (United States)

    Hermawan, I.; Lubis, A. M.; Sahputra, R.; Hill, E.; Sieh, K.; Feng, L.; Salman, R.; Hananto, N.


    The Sumatran Fault Zone (SFZ) accommodates a significant component of the strike-slip motion of oblique convergence along the Sumatra subduction zone. Previous studies have suggested that the slip rates of the SFZ increase from south to north. However, recent work shows that the slip rates may not vary along the SFZ [Bradley et al., 2015]. New data are needed to help confirm these results, and to assess slip-rate variability and fault segmentation in more detail. This information is vital for seismic hazard assessment for the region. We have therefore installed and operated the SuMo (Sumatran Fault Monitoring) network, a dense GPS campaign network focused around the SFZ. From 2013-2015 we selected and installed 32 GPS monuments over the southern part of the SFZ. The network comprises of three transects. The first transect is around the location of the great 1900 earthquake, at the Musi segment. Two transects cover the Manna segment, which saw its last great earthquake in 1893, and the Kumering segment, which saw two great earthquakes in 1933 (M 7.5) and 1994 (M 7.0). We have now conducted three GPS campaign surveys for these stations (3-4 days of measurement for each occupation site), and established 5 semi-permanent cGPS stations in the area. The processed data show that the campaigns sites are still too premature to be used for estimating slip rates, but from the preliminary results for the semi-permanent stations we may see our first signal of deformation. More data from future survey campaigns will help us to estimated revised slip rates. In addition to the science goals for our project, we are this year starting a project called "SuMo Goes to School," which will aim to disseminate information on our science to the schools that house the SuMo GPS stations. The SuMo project also achieves capacity building by training students from Bengkulu University in geodesy and campaign GPS survey techniques.

  6. K2 Ultracool Dwarfs Survey. III. White Light Flares Are Ubiquitous in M6-L0 Dwarfs (United States)

    Paudel, Rishi R.; Gizis, John E.; Mullan, D. J.; Schmidt, Sarah J.; Burgasser, Adam J.; Williams, Peter K. G.; Berger, Edo


    We report the white light flare rates for 10 ultracool dwarfs using Kepler K2 short-cadence data. Among our sample stars, two have spectral type M6, three are M7, three are M8, and two are L0. Most of our targets are old low-mass stars. We identify a total of 283 flares in all of the stars in our sample, with Kepler energies in the range log E Kp ∼ (29–33.5) erg. Using the maximum-likelihood method of line fitting, we find that the flare frequency distribution (FFD) for each star in our sample follows a power law with slope ‑α in the range ‑(1.3–2.0). We find that cooler objects tend to have shallower slopes. For some of our targets, the FFD follows either a broken power law, or a power law with an exponential cutoff. For the L0 dwarf 2MASS J12321827-0951502, we find a very shallow slope (‑α = ‑1.3) in the Kepler energy range (0.82–130) × 1030 erg: this L0 dwarf has flare rates which are comparable to those of high-energy flares in stars of earlier spectral types. In addition, we report photometry of two superflares: one on the L0 dwarf 2MASS J12321827-0951502 and another on the M7 dwarf 2MASS J08352366+1029318. In the case of 2MASS J12321827-0951502, we report a flare brightening by a factor of ∼144 relative to the quiescent photospheric level. Likewise, for 2MASS J08352366+1029318, we report a flare brightening by a factor of ∼60 relative to the quiescent photospheric level. These two superflares have bolometric (ultraviolet/optical/infrared) energies 3.6 × 1033 erg and 8.9 × 1033 erg respectively, while the full width half maximum timescales are very short, ∼2 min. We find that the M8 star TRAPPIST-1 is more active than the M8.5 dwarf 2M03264453+1919309, but less active than another M8 dwarf (2M12215066-0843197).

  7. Estudio de la inteligencia emocional y función ejecutiva en educación primaria

    Directory of Open Access Journals (Sweden)

    Rebollo Goñi, Edurne


    Full Text Available La Inteligencia Emocional y la Función Ejecutiva son clave en la educación por la influencia en el proceso de enseñanza-aprendizaje. El objetivo de este trabajo es analizar la relación entre la Inteligencia Emocional (intrapersonal e interpersonal y la Función Ejecutiva. Método: Los participantes (N=87, M=7.50, SD=1.03 eran escolares de Educación Primaria, a los que se les administró la prueba de Evaluación Neuropsicológica de Funciones Ejecutivas en niños (Portellano, Martínez y Zumárraga, 2009 para valorar las funciones ejecutivas, concretamente planificación, fluidez verbal e interferencia cognitiva y el Cuestionario de Inteligencias Múltiples de Armstrong (2001 con las escalas de inteligencia interpersonal e inteligencia intrapersonal para valorar Inteligencia Emocional. Se emplea un diseño ex postfacto, descriptivo y correlacional. Resultados: El análisis evidencia que existen relaciones significativas entre Inteligencia Emocional y Funciones Ejecutivas. Conclusiones: Resalta la relevancia de incluir en el currículo educativo programas de intervención neuropsicológica que trabajen habilidades emocionales y competencias ejecutivas para optimizar el rendimiento académico y personal del alumnado de Educación Primaria. Abstract: Emotional Intelligence and Executive Function are key in education due to their influence in the teaching-learning process. The aim of this research study is to analyze the relationship between emotional intelligence (intra and interpersonal and some of the components of executive functions. Method: The participants (N=87, M=7.50, SD=1.03 are students in Primary Education who were administered the Neuropsychological Assessment of Executive Functions in Children (Portellano, Martínez y Zumárraga, 2009 to assess executive functions, specifically planning, verbal fluency and cognitive interference as well as Armstrong’s questionnaire on Multiples Intelligences (2001 with scales of interpersonal

  8. Seismicity and lithospheric structure of Central Mozambique: implications for the southward propagation of the East African Rift System (United States)

    Fonseca, J. F. B. D.; Domingues, A.


    South of latitude 5ºS, there is scarce support for a single preferred location of continental rifting in SE Africa. Building on the complexity already displayed further north around the Victoria microplate, the structures associated with rifting activity are now distributed over three branches: one directed towards the SW through Zambia and into the Okawango rift in Botswana; one running offshore along the Mozambique Channel; and a central rift system through lake Malawi and Central Mozambique. Our investigation focuses on this central branch, whose tectonic relevance was highlighted by the M7 Machaze earthquake in 2006. Through the temporary deployment of 30 broadband stations in central Mozambique we were able to document that the Shire and Urema grabens linking the Malawi rift to the Machaze epicentral area are seismically active, correlating with a 300 km long narrow band of seismicity reaching the lower crust. No significant seismicity was recorded along the Mazenga graben, south of the Machaze epicentral area. A tomographic model derived from ambient noise analysis showed a strong correlation between the seismicity and a sharp NNE-SSW boundary between the fast crust of the Zimbabwe and Kaapvaal cratons and slower crust underneath the Mozambique Coastal Plains. The seismicity shuts down were this trend rotates to a more N-S direction as the Lebombo monocline is approached. 20th Century seismicity of SE Africa shows a clear cluster in time, with five M>6 earthquakes concentrated in the 1950's, distributed along the edges of the Zimbabwe craton and spanning distances of 600 km. Spatial correlation with such range is hard to reconcile with stress transmission in the crust and may point to the interaction of the cratonic root with asthenospheric flow. Under this light, the M6.5 Central Botswana earthquake of April 2017 and the M7 Machaze earthquake of 2006, both located in the vicinity of the borders of the Kaapvaal craton, may bear a similar correlation. The

  9. Space-time behavior of continental intraplate earthquakes and implications for hazard assessment in China and the Central U.S. (United States)

    Stein, Seth; Liu, Mian; Luo, Gang; Wang, Hui


    Earthquakes in midcontinents and those at plate boundaries behave quite differently in space and time, owing to the geometry of faults and the rate at which they are loaded. Faults at plate boundaries are loaded at constant rates by steady relative plate motion. Consequently, earthquakes concentrate along the plate boundary faults, and show quasi-periodic occurrences, although the actual temporal patterns are often complicated. However, in midcontinents, the tectonic loading is shared by a complex system of interacting faults spread over a large region, such that a large earthquake on one fault could increase the loading rates on remote faults in the system. Because the low tectonic loading rate is shared by many faults in midcontinents, individual faults may remain dormant for a long time and then become active for a short period. The resulting earthquakes are therefore episodic and spatially migrating. These effects can be seen in many areas, with a prime example being a 2000-year record from North China, which shows migration of large earthquakes between fault systems spread over a large region such that no large earthquakes rupture the same fault segment twice. Because seismic activity within mid-continents is usually much lower than that along plate boundary zones, even small earthquakes can cause widespread concerns, especially when these events occur in the source regions of previous large earthquakes. However, these small earthquakes may be aftershocks that continue for decades or even longer, because aftershock sequences often last much longer in midcontinents where tectonic loading is slow, than at plate boundaries. The recent seismicity in the Tangshan region in North China is likely aftershocks of the 1976 M7.8 Tangshan earthquake. Similarly, current seismicity in the New Madrid seismic zone in central U.S. appears to be aftershocks of a cluster of M ~7.0 events in 1811-1812. These large events and similar events in the past millennium release strain

  10. Time-lapse imaging of fault properties at seismogenic depth using repeating earthquakes, active sources and seismic ambient noise (United States)

    Cheng, Xin


    The time-varying stress field of fault systems at seismogenic depths plays the mort important role in controlling the sequencing and nucleation of seismic events. Using seismic observations from repeating earthquakes, controlled active sources and seismic ambient noise, five studies at four different fault systems across North America, Central Japan, North and mid-West China are presented to describe our efforts to measure such time dependent structural properties. Repeating and similar earthquakes are hunted and analyzed to study the post-seismic fault relaxation at the aftershock zone of the 1984 M 6.8 western Nagano and the 1976 M 7.8 Tangshan earthquakes. The lack of observed repeating earthquakes at western Nagano is attributed to the absence of a well developed weak fault zone, suggesting that the fault damage zone has been almost completely healed. In contrast, the high percentage of similar and repeating events found at Tangshan suggest the existence of mature fault zones characterized by stable creep under steady tectonic loading. At the Parkfield region of the San Andreas Fault, repeating earthquake clusters and chemical explosions are used to construct a scatterer migration image based on the observation of systematic temporal variations in the seismic waveforms across the occurrence time of the 2004 M 6 Parkfield earthquake. Coseismic fluid charge or discharge in fractures caused by the Parkfield earthquake is used to explain the observed seismic scattering properties change at depth. In the same region, a controlled source cross-well experiment conducted at SAFOD pilot and main holes documents two large excursions in the travel time required for a shear wave to travel through the rock along a fixed pathway shortly before two rupture events, suggesting that they may be related to pre-rupture stress induced changes in crack properties. At central China, a tomographic inversion based on the theory of seismic ambient noise and coda wave interferometry

  11. A comparison of GPS strain rate and seismicity in mainland China (United States)

    Ye, J.; Liu, M.


    The spatial distribution and moment release of earthquakes should correlate to crustal strain rates, assuming most of the crustal strain is released by earthquakes. However, the correlation between seismicity and crustal strain rates is not always clear, especially in continental interiors where large earthquakes are infrequent and earthquake records often incomplete. Here we compare seismicity and crustal strain rates in mainland China, where in the past decades the GPS measurements by the Crustal Motion Observation Network of China and other teams have determined the velocity at more than a thousand sites, allowing a meaningful calculation of the spatial distribution of the crustal strain rates. Our strain-rate map of mainland China is consistent with tectonic activities. The average scalar strain rate in West China is 17.5x10-16, contrasting to the much lower value (2.5x 10-16) in East China. The high strain rates are mainly found in the Tibetan Plateau, with the highest values clearly delineating the major active faults, including the Himalayan main boundary thrust, the Xianshuihe fault, the Longmanshan fault, the Haiyuan fault, and the southern Tianshan boundary fault. North China also has relatively high strain rates, but the high strain rates around the cities of Tangshan and Xingtai likely result from postseismic deformation following the 1966 Xingtai earthquake (M 7.2) and the 1976 Tangshan earthquake (M 7.8). We calculated the seismic moment release using the Chinese earthquake catalog that goes back to more than 2000 years. The spatial pattern of cumulative seismic moment release is generally comparable with that of the strain rates. Regions of major discrepancies include the Weihe-Shanxi grabens, which had numerous large earthquakes but have been quiescent in the past 300 years. When we use smaller time windows (200 or 500 years) to calculate the seismic moment release, we found strongly variable spatial patterns that is generally incomparable with the

  12. The 2008 Wenchuan Earthquake and the Rise and Fall of Earthquake Prediction in China (United States)

    Chen, Q.; Wang, K.


    Regardless of the future potential of earthquake prediction, it is presently impractical to rely on it to mitigate earthquake disasters. The practical approach is to strengthen the resilience of our built environment to earthquakes based on hazard assessment. But this was not common understanding in China when the M 7.9 Wenchuan earthquake struck the Sichuan Province on 12 May 2008, claiming over 80,000 lives. In China, earthquake prediction is a government-sanctioned and law-regulated measure of disaster prevention. A sudden boom of the earthquake prediction program in 1966-1976 coincided with a succession of nine M > 7 damaging earthquakes in the densely populated region of the country and the political chaos of the Cultural Revolution. It climaxed with the prediction of the 1975 Haicheng earthquake, which was due mainly to an unusually pronounced foreshock sequence and the extraordinary readiness of some local officials to issue imminent warning and evacuation order. The Haicheng prediction was a success in practice and yielded useful lessons, but the experience cannot be applied to most other earthquakes and cultural environments. Since the disastrous Tangshan earthquake in 1976 that killed over 240,000 people, there have been two opposite trends in China: decreasing confidence in prediction and increasing emphasis on regulating construction design for earthquake resilience. In 1976, most of the seismic intensity XI areas of Tangshan were literally razed to the ground, but in 2008, many buildings in the intensity XI areas of Wenchuan did not collapse. Prediction did not save life in either of these events; the difference was made by construction standards. For regular buildings, there was no seismic design in Tangshan to resist any earthquake shaking in 1976, but limited seismic design was required for the Wenchuan area in 2008. Although the construction standards were later recognized to be too low, those buildings that met the standards suffered much less

  13. Lower crustal earthquakes in the North China Basin and implications for crustal rheology (United States)

    Yuen, D. A.; Dong, Y.; Ni, S.; LI, Z.


    The North China Basin is a Mesozoic-Cenozoic continental rift basin on the eastern North China Craton. It is the central region of craton destruction, also a very seismically active area suffering severely from devastating earthquakes, such as the 1966 Xingtai M7.2 earthquake, the 1967 Hejian M6.3 earthquake, and the 1976 Tangshan M7.8 earthquake. We found remarkable discrepancies of depth distribution among the three earthquakes, for instance, the Xingtai and Tangshan earthquakes are both upper-crustal earthquakes occurring between 9 and 15 km on depth, but the depth of the Hejian earthquake was reported of about 30 72 km, ranging from lowermost crust to upper mantle. In order to investigate the focal depth of earthquakes near Hejian area, we developed a method to resolve focal depth for local earthquakes occurring beneath sedimentary regions by P and S converted waves. With this method, we obtained well-resolved depths of 44 local events with magnitudes between M1.0 and M3.0 during 2008 to 2016 at the Hejian seismic zone, with a mean depth uncertainty of about 2 km. The depth distribution shows abundant earthquakes at depth of 20 km, with some events in the lower crust, but absence of seismicity deeper than 25 km. In particular, we aimed at deducing some constraints on the local crustal rheology from depth-frequency distribution. Therefore, we performed a comparison between the depth-frequency distribution and the crustal strength envelop, and found a good fit between the depth profile in the Hejian seismic zone and the yield strength envelop in the Baikal Rift Systems. As a conclusion, we infer that the seismogenic thickness is 25 km and the main deformation mechanism is brittle fracture in the North China Basin . And we made two hypotheses: (1) the rheological layering of dominant rheology in the North China Basin is similar to that of the Baikal Rift Systems, which can be explained with a quartz rheology at 0 10 km depth and a diabase rheology at 10 35 km

  14. Correlation between Condylar Fracture Pattern after Parasymphyseal Impact and Condyle Morphological Features: A Retrospective Analysis of 107 Chinese Patients. (United States)

    Han, Lu; Long, Ting; Tang, Wei; Liu, Lei; Jing, Wei; Tian, Wei-Dong; Long, Jie


    The treatment of the condylar fractures is difficult. Factors that result in the fractures are complex. The objective of this morphometric study was to investigate the relationship between condylar fracture patterns and condylar morphological characteristics. We conducted a retrospective analysis of 107 patients admitted to the West China Hospital of Stomatology for bilateral condylar fractures caused by parasymphyseal impact. The patients were divided into five groups according to the type of condylar fracture. Ten parameters were evaluated on three-dimensional (3D) reconstruction mandible models through the Mimics 16.0 (Materialize Leuven, Belgium) anthropometry toolkit. Each parameter of the 3D models was analyzed using multivariate analysis. Multinomial logistic regression analyses were used to examine the relationships between the five groups. The results showed that the differences of condylar head width (M1), condylar neck width (M3), the ratio of condylar head width to condylar anteroposterior diameter (M1/M2), the ratio of condylar head width to condylar neck width (M1/M3), the ratio of condylar height to ramus height (M8/M7), and mandibular angle (M10) were statistically significant (p fractures were positively associated with M1 (compared to Type B: OR =1.627, 95% CI: 1.123, 2.359; compared to Type C: OR = 1.705, 95% CI: 1.170, 2.484) and M1/M2 (compared to Type B: OR =1.034, 95% CI: 0.879, 2.484). Type B condylar head fractures were negatively associated with M10 (compared to Type C: OR = 0.909, 95% CI: 0.821, 1.007). Condylar neck fractures were negatively associated with M3 (compared to condylar head: OR = 0.382, CI: 0.203, 0.720 ; compared to condylar base: OR = 0.436, 95% CI: 0.218, 0.874), and positively associated with M1/M3 (compared to condylar head: OR = 1.229, 95% CI: 1.063, 1.420 compared to condylar base: OR = 1.223, 95% CI: 1.034, 1.447). Condylar base fractures were positively associated with M10 (OR = 1.095, 95% CI: 1.008, 1.189) and

  15. Earthquake Triggering in the September 2017 Mexican Earthquake Sequence (United States)

    Fielding, E. J.; Gombert, B.; Duputel, Z.; Huang, M. H.; Liang, C.; Bekaert, D. P.; Moore, A. W.; Liu, Z.; Ampuero, J. P.


    Southern Mexico was struck by four earthquakes with Mw > 6 and numerous smaller earthquakes in September 2017, starting with the 8 September Mw 8.2 Tehuantepec earthquake beneath the Gulf of Tehuantepec offshore Chiapas and Oaxaca. We study whether this M8.2 earthquake triggered the three subsequent large M>6 quakes in southern Mexico to improve understanding of earthquake interactions and time-dependent risk. All four large earthquakes were extensional despite the the subduction of the Cocos plate. The traditional definition of aftershocks: likely an aftershock if it occurs within two rupture lengths of the main shock soon afterwards. Two Mw 6.1 earthquakes, one half an hour after the M8.2 beneath the Tehuantepec gulf and one on 23 September near Ixtepec in Oaxaca, both fit as traditional aftershocks, within 200 km of the main rupture. The 19 September Mw 7.1 Puebla earthquake was 600 km away from the M8.2 shock, outside the standard aftershock zone. Geodetic measurements from interferometric analysis of synthetic aperture radar (InSAR) and time-series analysis of GPS station data constrain finite fault total slip models for the M8.2, M7.1, and M6.1 Ixtepec earthquakes. The early M6.1 aftershock was too close in time and space to the M8.2 to measure with InSAR or GPS. We analyzed InSAR data from Copernicus Sentinel-1A and -1B satellites and JAXA ALOS-2 satellite. Our preliminary geodetic slip model for the M8.2 quake shows significant slip extended > 150 km NW from the hypocenter, longer than slip in the v1 finite-fault model (FFM) from teleseismic waveforms posted by G. Hayes at USGS NEIC. Our slip model for the M7.1 earthquake is similar to the v2 NEIC FFM. Interferograms for the M6.1 Ixtepec quake confirm the shallow depth in the upper-plate crust and show centroid is about 30 km SW of the NEIC epicenter, a significant NEIC location bias, but consistent with cluster relocations (E. Bergman, pers. comm.) and with Mexican SSN location. Coulomb static stress

  16. Effect of reduced dose schedules and intramuscular injection of anthrax vaccine adsorbed on immunological response and safety profile: a randomized trial. (United States)

    Wright, Jennifer G; Plikaytis, Brian D; Rose, Charles E; Parker, Scott D; Babcock, Janiine; Keitel, Wendy; El Sahly, Hana; Poland, Gregory A; Jacobson, Robert M; Keyserling, Harry L; Semenova, Vera A; Li, Han; Schiffer, Jarad; Dababneh, Hanan; Martin, Sandra K; Martin, Stacey W; Marano, Nina; Messonnier, Nancy E; Quinn, Conrad P


    We evaluated an alternative administration route, reduced schedule priming series, and increased intervals between booster doses for anthrax vaccine adsorbed (AVA). AVA's originally licensed schedule was 6 subcutaneous (SQ) priming injections administered at months (m) 0, 0.5, 1, 6, 12 and 18 with annual boosters; a simpler schedule is desired. Through a multicenter randomized, double blind, non-inferiority Phase IV human clinical trial, the originally licensed schedule was compared to four alternative and two placebo schedules. 8-SQ group participants received 6 SQ injections with m30 and m42 "annual" boosters; participants in the 8-IM group received intramuscular (IM) injections according to the same schedule. Reduced schedule groups (7-IM, 5-IM, 4-IM) received IM injections at m0, m1, m6; at least one of the m0.5, m12, m18, m30 vaccine doses were replaced with saline. All reduced schedule groups received a m42 booster. Post-injection blood draws were taken two to four weeks following injection. Non-inferiority of the alternative schedules was compared to the 8-SQ group at m2, m7, and m43. Reactogenicity outcomes were proportions of injection site and systemic adverse events (AEs). The 8-IM group's m2 response was non-inferior to the 8-SQ group for the three primary endpoints of anti-protective antigen IgG geometric mean concentration (GMC), geometric mean titer, and proportion of responders with a 4-fold rise in titer. At m7 anti-PA IgG GMCs for the three reduced dosage groups were non-inferior to the 8-SQ group GMCs. At m43, 8-IM, 5-IM, and 4-IM group GMCs were superior to the 8-SQ group. Solicited injection site AEs occurred at lower proportions in the IM group compared to SQ. Route of administration did not influence the occurrence of systemic AEs. A 3 dose IM priming schedule with doses administered at m0, m1, and m6 elicited long term immunological responses and robust immunological memory that was efficiently stimulated by a single booster vaccination at

  17. 5'-Phospho-RNA Acceptor Specificity of GDP Polyribonucleotidyltransferase of Vesicular Stomatitis Virus in mRNA Capping. (United States)

    Ogino, Minako; Ogino, Tomoaki


    The GDP polyribonucleotidyltransferase (PRNTase) domain of the multifunctional L protein of rhabdoviruses, such as vesicular stomatitis virus (VSV) and rabies virus, catalyzes the transfer of 5'-phospho-RNA (pRNA) from 5'-triphospho-RNA (pppRNA) to GDP via a covalent enzyme-pRNA intermediate to generate a 5'-cap structure (GpppA). Here, using an improved oligo-RNA capping assay with the VSV L protein, we showed that the Michaelis constants for GDP and pppAACAG (VSV mRNA-start sequence) are 0.03 and 0.4 μM, respectively. A competition assay between GDP and GDP analogues in the GpppA formation and pRNA transfer assay using GDP analogues as pRNA acceptors indicated that the PRNTase domain recognizes the C-2-amino group, but not the C-6-oxo group, N-1-hydrogen, or N-7-nitrogen, of GDP for the cap formation. 2,6-Diaminopurine-riboside (DAP), 7-deazaguanosine (7-deaza-G), and 7-methylguanosine (m 7 G) diphosphates efficiently accepted pRNA, resulting in the formation of DAPpppA, 7-deaza-GpppA, and m 7 GpppA (cap 0), respectively. Furthermore, either the 2'- or 3'-hydroxyl group of GDP was found to be required for efficient pRNA transfer. A 5'-diphosphate form of antiviral ribavirin weakly inhibited the GpppA formation but did not act as a pRNA acceptor. These results indicate that the PRNTase domain has a unique guanosine-binding mode different from that of eukaryotic mRNA capping enzyme, guanylyltransferase. IMPORTANCE mRNAs of nonsegmented negative-strand (NNS) RNA viruses, such as VSV, possess a fully methylated cap structure, which is required for mRNA stability, efficient translation, and evasion of antiviral innate immunity in host cells. GDP polyribonucleotidyltransferase (PRNTase) is an unconventional mRNA capping enzyme of NNS RNA viruses that is distinct from the eukaryotic mRNA capping enzyme, guanylyltransferase. In this study, we studied the pRNA acceptor specificity of VSV PRNTase using various GDP analogues and identified chemical groups of GDP as

  18. 5′-Phospho-RNA Acceptor Specificity of GDP Polyribonucleotidyltransferase of Vesicular Stomatitis Virus in mRNA Capping (United States)

    Ogino, Minako


    ABSTRACT The GDP polyribonucleotidyltransferase (PRNTase) domain of the multifunctional L protein of rhabdoviruses, such as vesicular stomatitis virus (VSV) and rabies virus, catalyzes the transfer of 5′-phospho-RNA (pRNA) from 5′-triphospho-RNA (pppRNA) to GDP via a covalent enzyme-pRNA intermediate to generate a 5′-cap structure (GpppA). Here, using an improved oligo-RNA capping assay with the VSV L protein, we showed that the Michaelis constants for GDP and pppAACAG (VSV mRNA-start sequence) are 0.03 and 0.4 μM, respectively. A competition assay between GDP and GDP analogues in the GpppA formation and pRNA transfer assay using GDP analogues as pRNA acceptors indicated that the PRNTase domain recognizes the C-2-amino group, but not the C-6-oxo group, N-1-hydrogen, or N-7-nitrogen, of GDP for the cap formation. 2,6-Diaminopurine-riboside (DAP), 7-deazaguanosine (7-deaza-G), and 7-methylguanosine (m7G) diphosphates efficiently accepted pRNA, resulting in the formation of DAPpppA, 7-deaza-GpppA, and m7GpppA (cap 0), respectively. Furthermore, either the 2′- or 3′-hydroxyl group of GDP was found to be required for efficient pRNA transfer. A 5′-diphosphate form of antiviral ribavirin weakly inhibited the GpppA formation but did not act as a pRNA acceptor. These results indicate that the PRNTase domain has a unique guanosine-binding mode different from that of eukaryotic mRNA capping enzyme, guanylyltransferase. IMPORTANCE mRNAs of nonsegmented negative-strand (NNS) RNA viruses, such as VSV, possess a fully methylated cap structure, which is required for mRNA stability, efficient translation, and evasion of antiviral innate immunity in host cells. GDP polyribonucleotidyltransferase (PRNTase) is an unconventional mRNA capping enzyme of NNS RNA viruses that is distinct from the eukaryotic mRNA capping enzyme, guanylyltransferase. In this study, we studied the pRNA acceptor specificity of VSV PRNTase using various GDP analogues and identified chemical groups

  19. Anaerobic Psychrophiles from Lake Zub and Lake Untersee, Antarctica (United States)

    Townsend, Alisa; Pikuta, Elena V.; Guisler, Melissa; Stahl, Sarah; Hoover, Richard B.


    The study of samples from Antarctica 2008 and 2009 expeditions organized and successfully conducted by Richard Hoover led to the isolation of diverse anaerobic strains with psychrotolerant and psychrophilic physiology. Due to the fact that Lake Untersee has never been subject to microbiological study, this work with the samples has significant and pioneering impact to the knowledge about the biology of this unique ecosystem. Also, the astrobiological significance for the study of these ecosystems is based on new findings of ice covered water systems on other bodies of our solar system. Anaerobic psychrotolerant strain LZ-22 was isolated from a frozen sample of green moss with soils around the rhizosphere collected near Lake Zub in Antarctica. Morphology of strain LZ-22 was observed to be motile, rod shaped and spore-forming cells with sizes 1 x 5-10 micron. This new isolate is a mesophile with the maximum temperature of growth at 40C. Strain LZ-22 is able to live on media without NaCl and in media with up to 7% (w/v) NaCl. It is catalase negative and grows only on sugars with the best growth rate being on lactose. The strain is a neutrophile and grows between pH 5 and 9.0 with the optimum at 7.8. Another two strains UL7-96mG and LU-96m7P were isolated from deep water samples of Lake Untersee. Proteolytic strain LU-96m7P had a truly psychrophilic nature and refused to grow at room temperature. Sugarlytic strain UL7-96mG was found to be psychrotolerant, but its rate of growth at 3C was very high compared with other mesophiles. Two homoacetogenic psychrophilic strains A7AC-96m and AC-DS7 were isolated and purified from samples of Lake Untersee; both of them are able to grow chemolithotrophically on H2+CO2. In the presence of lactate, these strains are able to grow only at 0-18C, and growth at 22C was observed only with yeast extract stimulation. In this paper, physiological and morphological characteristics of novel psychrophilic and psychrotolerant isolates from

  20. FDM simulation of earthquakes off western Kyushu, Japan, using a land-ocean unified 3D structure model (United States)

    Okamoto, Taro; Takenaka, Hiroshi; Nakamura, Takeshi; Hara, Tatsuhiko


    Seismic activity occurred off western Kyushu, Japan, at the northern end of the Okinawa Trough on May 6, 2016 (14:11 JST), 22 days after the onset of the 2016 Kumamoto earthquake sequence. The area is adjacent to the Beppu-Shimabara graben where the 2016 Kumamoto earthquake sequence occurred. In the area off western Kyushu, a M7.1 earthquake also occurred on November 14, 2015 (5:51 JST), and a tsunami with a height of 0.3 m was observed. In order to better understand these seismic activity and tsunamis, it is necessary to study the sources of, and strong motions due to, earthquakes in the area off western Kyushu. For such studies, validation of synthetic waveforms is important because of the presence of the oceanic water layer and thick sediments in the source area. We show the validation results for synthetic waveforms through nonlinear inversion analyses of small earthquakes ( M5). We use a land-ocean unified 3D structure model, 3D HOT finite-difference method ("HOT" stands for Heterogeneity, Ocean layer and Topography) and a multi-graphic processing unit (GPU) acceleration to simulate the wave propagations. We estimate the first-motion augmented moment tensor (FAMT) solution based on both the long-period surface waves and short-period body waves. The FAMT solutions systematically shift landward by about 13 km, on average, from the epicenters determined by the Japan Meteorological Agency. The synthetics provide good reproductions of the observed full waveforms with periods of 10 s or longer. On the other hand, for waveforms with shorter periods (down to 4 s), the later surface waves are not reproduced well, while the first parts of the waveforms (comprising P- and S-waves) are reproduced to some extent. These results indicate that the current 3D structure model around Kyushu is effective for generating full waveforms, including surface waves with periods of about 10 s or longer. Based on these findings, we analyze the 2015 M7.1 event using the cross

  1. Earthquakes of Garhwal Himalaya region of NW Himalaya, India: A study of relocated earthquakes and their seismogenic source and stress (United States)

    R, A. P.; Paul, A.; Singh, S.


    Since the continent-continent collision 55 Ma, the Himalaya has accommodated 2000 km of convergence along its arc. The strain energy is being accumulated at a rate of 37-44 mm/yr and releases at time as earthquakes. The Garhwal Himalaya is located at the western side of a Seismic Gap, where a great earthquake is overdue atleast since 200 years. This seismic gap (Central Seismic Gap: CSG) with 52% probability for a future great earthquake is located between the rupture zones of two significant/great earthquakes, viz. the 1905 Kangra earthquake of M 7.8 and the 1934 Bihar-Nepal earthquake of M 8.0; and the most recent one, the 2015 Gorkha earthquake of M 7.8 is in the eastern side of this seismic gap (CSG). The Garhwal Himalaya is one of the ideal locations of the Himalaya where all the major Himalayan structures and the Himalayan Seimsicity Belt (HSB) can ably be described and studied. In the present study, we are presenting the spatio-temporal analysis of the relocated local micro-moderate earthquakes, recorded by a seismicity monitoring network, which is operational since, 2007. The earthquake locations are relocated using the HypoDD (double difference hypocenter method for earthquake relocations) program. The dataset from July, 2007- September, 2015 have been used in this study to estimate their spatio-temporal relationships, moment tensor (MT) solutions for the earthquakes of M>3.0, stress tensors and their interactions. We have also used the composite focal mechanism solutions for small earthquakes. The majority of the MT solutions show thrust type mechanism and located near the mid-crustal-ramp (MCR) structure of the detachment surface at 8-15 km depth beneath the outer lesser Himalaya and higher Himalaya regions. The prevailing stress has been identified to be compressional towards NNE-SSW, which is the direction of relative plate motion between the India and Eurasia continental plates. The low friction coefficient estimated along with the stress inversions

  2. Assessment of rice yield loss due to exposure to ozone pollution in Southern Vietnam

    International Nuclear Information System (INIS)

    Danh, Ngo Thanh; Huy, Lai Nguyen; Oanh, Nguyen Thi Kim


    The study domain covered the Eastern region of Southern of Vietnam that includes Ho Chi Minh City (HCMC) and five other provinces. Rice production in the domain accounted for 13% of the national total with three crop cycles per year. We assessed ozone (O 3 ) induced rice production loss in the domain for 2010 using simulated hourly surface O 3 concentrations (WRF/CAMx; 4 km resolution). Simulated O 3 was higher in January–February (largely overlaps the first crop) and September–December (third crop), and lower in March–June (second crop). Spatially, O 3 was higher in downwind locations of HCMC and were comparable with observed data. Relative yield loss (RYL) was assessed for each crop over the respective growing period (105 days) using three metrics: AOT40, M7 and flux-based O 3 dose of POD 10 . Higher RYL was estimated for the downwind of HCMC. Overall, the rice production loss due to O 3 exposure in the study domain in 2010 was the highest for the first crop (up to 25,800 metric tons), the second highest for the third crop (up to 21,500 tons) and the least for the second crop (up to 6800 tons). The low RYL obtained for the second crop by POD 10 may be due to the use of a high threshold value (Y = 10 nmol m −2 s −1 ). Linear regression between non-null radiation POD 0 and POD 10 had similar slopes for the first and third crop when POD 0 was higher and very low slope for the second crop when POD 0 was low. The results of this study can be used for the rice crop planning to avoid the period of potential high RYL due to O 3 exposure. - Highlights: • Simulated O 3 was used to assess rice yield loss in a domain of Southern Vietnam. • Exposure metrics of AOT40, M7, POD 0 and POD 10 were considered. • POD 10 gave the highest rice production loss. • Higher production loss was found downwind of Ho Chi Minh City.


    Energy Technology Data Exchange (ETDEWEB)

    Bowler, Brendan P.; Montet, Benjamin T.; Riddle, Reed [California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125 (United States); Shkolnik, Evgenya L.; Flagg, Laura [Lowell Observatory, 1400 W. Mars Hill Road, Flagstaff, AZ 86001 (United States); Liu, Michael C.; Howard, Andrew W.; Aller, Kimberly M.; Best, William M. J.; Kotson, Michael C.; Baranec, Christoph [Institute for Astronomy, University of Hawai‘i at Mānoa, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Schlieder, Joshua E. [NASA Postdoctoral Program Fellow, NASA Ames Research Center, MS-245-3, Moffett Field, CA 94035 (United States); Mann, Andrew W.; Dupuy, Trent J. [Department of Astronomy, University of Texas at Austin, TX (United States); Hinkley, Sasha [Physics and Astronomy, University of Exeter, EX4 4QL Exeter (United Kingdom); Crepp, Justin R. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Johnson, John Asher [Harvard–Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Weinberger, Alycia J. [Department of Terrestrial Magnetism, Carnegie Institution of Washington, 5241 Broad Branch Rd NW, Washington, DC 20015 (United States); Allers, Katelyn N. [Department of Physics and Astronomy, Bucknell University, Lewisburg, PA 17837 (United States); Herczeg, Gregory J., E-mail: [Kavli Institute for Astronomy and Astrophysics, Peking University, Yi He Yuan Lu 5, Hai Dian Qu, Beijing 100871 (China); and others


    We present optical and near-infrared adaptive optics (AO) imaging and spectroscopy of 13 ultracool (>M6) companions to late-type stars (K7–M4.5), most of which have recently been identified as candidate members of nearby young moving groups (YMGs; 8–120 Myr) in the literature. Three of these are new companions identified in our AO imaging survey, and two others are confirmed to be comoving with their host stars for the first time. The inferred masses of the companions (∼10–100 M{sub Jup}) are highly sensitive to the ages of the primary stars; therefore we critically examine the kinematic and spectroscopic properties of each system to distinguish bona fide YMG members from old field interlopers. The new M7 substellar companion 2MASS J02155892–0929121 C (40–60 M{sub Jup}) shows clear spectroscopic signs of low gravity and, hence, youth. The primary, possibly a member of the ∼40 Myr Tuc-Hor moving group, is visually resolved into three components, making it a young low-mass quadruple system in a compact (≲100 AU) configuration. In addition, Li i λ6708 absorption in the intermediate-gravity M7.5 companion 2MASS J15594729+4403595 B provides unambiguous evidence that it is young (≲200 Myr) and resides below the hydrogen-burning limit. Three new close-separation (<1″) companions (2MASS J06475229–2523304 B, PYC J11519+0731 B, and GJ 4378 Ab) orbit stars previously reported as candidate YMG members, but instead are likely old (≳1 Gyr) tidally locked spectroscopic binaries without convincing kinematic associations with any known moving group. The high rate of false positives in the form of old active stars with YMG-like kinematics underscores the importance of radial velocity and parallax measurements to validate candidate young stars identified via proper motion and activity selection alone. Finally, we spectroscopically confirm the cool temperature and substellar nature of HD 23514 B, a recently discovered M8 benchmark brown dwarf orbiting the

  4. Retrospective analysis for detecting seismic precursors in groundwater argon content

    Directory of Open Access Journals (Sweden)

    P. F. Biagi


    Full Text Available We examined the groundwater Argon content data sampled from 1988 to 2001 at two wells in Kamchatka (Russia and anomalous increases appeared clearly during June-July 1996. On 21 June, a shallow (1km earthquake with M=7.1 occurred at a distance less than 250km from the wells and so the previous increases could be related to this earthquake and, in particular, could be considered premonitory anomalies. In order to support this raw interpretation, we analysed the data collected in details. At first we smoothed out the high frequency fluctuations arising from the errors in a single measurement. Next we considered the known external effects on the water of a well that are the slow tectonic re-adjustment processes, the meteorology and the gravity tides and we separated these effects applying band-pass filters to the Argon content raw trends. Then we identified the largest fluctuations in these trends applying the 3 σ criterion and we found three anomalies in a case and two anomalies in other case. Comparing the time occurrence of the anomalies at the two wells we found out that a coincidence exists only in the case of the premonitory anomalies we are studying. The simultaneous appearance of well definite anomalies in the residual trends of the same parameter at two different sites supports their meaning and the possibility that they are related to some large scale effect, as the occurrence of a strong earthquake. But, other earthquakes similar to the June 1996 event took place during the Argon content measurements time and no anomaly appeared in this content. In the past, some of the authors of this paper studied the Helium content data collected in three natural springs of the Caucasus during seven years. A very similar result, that is the simultaneous appearance of clear premonitory anomalies only on the occasion of a strong (M=7.0 but shallow (2–4km earthquake, was obtained. The correspondence with the case of the Caucasus validates the


    International Nuclear Information System (INIS)

    Bowler, Brendan P.; Montet, Benjamin T.; Riddle, Reed; Shkolnik, Evgenya L.; Flagg, Laura; Liu, Michael C.; Howard, Andrew W.; Aller, Kimberly M.; Best, William M. J.; Kotson, Michael C.; Baranec, Christoph; Schlieder, Joshua E.; Mann, Andrew W.; Dupuy, Trent J.; Hinkley, Sasha; Crepp, Justin R.; Johnson, John Asher; Weinberger, Alycia J.; Allers, Katelyn N.; Herczeg, Gregory J.


    We present optical and near-infrared adaptive optics (AO) imaging and spectroscopy of 13 ultracool (>M6) companions to late-type stars (K7–M4.5), most of which have recently been identified as candidate members of nearby young moving groups (YMGs; 8–120 Myr) in the literature. Three of these are new companions identified in our AO imaging survey, and two others are confirmed to be comoving with their host stars for the first time. The inferred masses of the companions (∼10–100 M Jup ) are highly sensitive to the ages of the primary stars; therefore we critically examine the kinematic and spectroscopic properties of each system to distinguish bona fide YMG members from old field interlopers. The new M7 substellar companion 2MASS J02155892–0929121 C (40–60 M Jup ) shows clear spectroscopic signs of low gravity and, hence, youth. The primary, possibly a member of the ∼40 Myr Tuc-Hor moving group, is visually resolved into three components, making it a young low-mass quadruple system in a compact (≲100 AU) configuration. In addition, Li i λ6708 absorption in the intermediate-gravity M7.5 companion 2MASS J15594729+4403595 B provides unambiguous evidence that it is young (≲200 Myr) and resides below the hydrogen-burning limit. Three new close-separation (<1″) companions (2MASS J06475229–2523304 B, PYC J11519+0731 B, and GJ 4378 Ab) orbit stars previously reported as candidate YMG members, but instead are likely old (≳1 Gyr) tidally locked spectroscopic binaries without convincing kinematic associations with any known moving group. The high rate of false positives in the form of old active stars with YMG-like kinematics underscores the importance of radial velocity and parallax measurements to validate candidate young stars identified via proper motion and activity selection alone. Finally, we spectroscopically confirm the cool temperature and substellar nature of HD 23514 B, a recently discovered M8 benchmark brown dwarf orbiting the dustiest

  6. Los conjuntos palaciegos reales de las Tierras Bajas Mayas del sur: una evaluación de los datos arqueológicos e iconográficos Royal palace complexes in Southern Maya Lowlands: evaluating archaeological and iconographical data

    Directory of Open Access Journals (Sweden)

    Kai Delvendahl


    Full Text Available Este artículo va a trazar algunas conclusiones de una evaluación de los aspectos físicos, espaciales, funcionales y sociales de los conjuntos palaciegos reales tomando en cuenta evidencia arqueológica e iconográfica. Para el componente iconográfico se analizaron representaciones de escenas palaciegas pintadas sobre 87 vasijas cilíndricas de cerámica, mientras que para el componente arqueológico se evaluó información de conjuntos palaciegos bien documentados como el Grupo Palaciego M7 de Aguateca, el Palacio de Palenque, Los 27 Escalones de Kohunlich, el Grupo 10L-2 de Copán, la Acrópolis Central de Tikal y el Grupo Gran Acrópolis de Calakmul. Uno de los objetivos generales de este trabajo es proporcionar un ejemplo de cómo se puede capitalizar la información que las escenas palaciegas proveen (al comparar el corpus iconográfico con el dato arqueológico. Esto permitiría plantear ideas más ajustadas sobre los aspectos físicos, espaciales, funcionales y sociales de los conjuntos palaciegos del Clásico Tardío en el área maya.This paper will present some conclusions of an evaluation of the physical, spatial, functional, and social aspects of Classic Maya royal palaces taking into account archaeological and iconographic evidence. For the iconographic evaluation, the analysis examined representations of palace-like ambience on 87 cylindrical ceramic vases, while the archaeological information includes data from the better documented palace groups of the Southern Maya Lowlands, including the Palace Group M7 of Aguateca, the Palace of Palenque, Los 27 Escalones of Kohunlich, Group 10L-2 of Copan, the Central Acropolis of Tikal and the Grand Acropolis Group of Calakmul. In comparing the iconographic corpus with the archaeological evidence, one of the general objectives of this presentation is to provide an example of how the information inherent in the palace scenes can be capitalized to propose more adjusted ideas about the

  7. The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of beta-carotene into astaxanthin and other xanthophylls. (United States)

    Alvarez, Vanessa; Rodríguez-Sáiz, Marta; de la Fuente, Juan Luis; Gudiña, Eduardo J; Godio, Ramiro P; Martín, Juan F; Barredo, José Luis


    The conversion of beta-carotene into xanthophylls is a subject of great scientific and industrial interest. We cloned the crtS gene involved in astaxanthin biosynthesis from two astaxanthin producing strains of Xanthophyllomyces dendrorhous: VKPM Y2410, an astaxanthin overproducing strain, and the wild type ATCC 24203. In both cases, the ORF has a length of 3166 bp, including 17 introns, and codes for a protein of 62.6 kDa with similarity to cytochrome-P450 hydroxylases. crtS gene sequences from strains VKPM Y2410, ATCC 24203, ATCC 96594, and ATCC 96815 show several nucleotide changes, but none of them causes any amino acid substitution, except a G2268 insertion in the 13th exon of ATCC 96815 which causes a change in the reading frame. A G1470 --> A change in the 5' splicing region of intron 8 was also found in ATCC 96815. Both point mutations explain astaxanthin idiotrophy and beta-carotene accumulation in ATCC 96815. Mutants accumulating precursors of the astaxanthin biosynthetic pathway were selected from the parental strain VKPM Y2410 (red) showing different colors depending on the compound accumulated. Two of them were blocked in the biosynthesis of astaxanthin, M6 (orange; 1% astaxanthin, 71 times more beta-carotene) and M7 (orange; 1% astaxanthin, 58 times more beta-carotene, 135% canthaxanthin), whereas the rest produced lower levels of astaxanthin (5-66%) than the parental strain. When the crtS gene was expressed in M7, canthaxanthin accumulation disappeared and astaxanthin production was partially restored. Moreover, astaxanthin biosynthesis was restored when X. dendrorhous ATCC 96815 was transformed with the crtS gene. The crtS gene was heterologously expressed in Mucor circinelloides conferring to this fungus an improved capacity to synthesize beta-cryptoxanthin and zeaxanthin, two hydroxylated compounds from beta-carotene. These results show that the crtS gene is involved in the conversion of beta-carotene into xanthophylls, being potentially useful to

  8. Search for Anisotropy Changes Associated with Two Large Earthquakes in Japan and New Zealand (United States)

    Savage, M. K.; Graham, K.; Aoki, Y.; Arnold, R.


    Seismic anisotropy is often considered to be an indicator of stress in the crust, because the closure of cracks due to differential stress leads to waves polarized parallel to the cracks travelling faster than the orthogonal direction. Changes in shear wave splitting have been suggested to result from stress changes at volcanoes and earthquakes. However, the effects of mineral or structural alignment, and the difficulty of distinguishing between changes in anisotropy along an earthquake-station path from distinguishing changes in the path itself, have made such findings controversial. Two large earthquakes in 2016 provide unique datasets to test the use of shear wave splitting for measuring variations in stress because clusters of closely-spaced earthquakes occurred both before and after a mainshock. We use the automatic, objective splitting analysis code MFAST to speed process and minimize unwitting observer bias when determining time variations. The sequence of earthquakes related to the M=7.2 Japanese Kumamoto earthquake of 14 April 2016 includes both foreshocks, mainshocks and aftershocks. The sequence was recorded by the NIED permanent network, which already contributed background seismic anisotropy measurements in a previous study of anisotropy and stress in Kyushu. Preliminary measurements of shear wave splitting from earthquakes that occurred in 2016 show results at some stations that clearly differ from those of the earlier study. They also change between earthquakes recorded before and after the mainshock. Further work is under way to determine whether the changes are more likely due to changes in stress during the observation time, or due to spatial changes in anisotropy combined with changes in earthquake locations. Likewise, background seismicity and also foreshocks and aftershocks in the 2013 Cook Strait earthquake sequence including two M=6.5 earthquakes in 2013 in New Zealand were in the same general region as aftershocks of the M=7.8 Kaikoura

  9. High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma (United States)


    Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With T(15;17)(q22;q12); Adult Acute Myeloid Leukemia With T(16;16)(p13;q22); Adult Acute Myeloid Leukemia With T(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Acute Promyelocytic Leukemia (M3); Adult Erythroleukemia (M6a); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Adult Pure Erythroid Leukemia (M6b); Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Burkitt Lymphoma; Childhood Acute Erythroleukemia (M6); Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myeloid Leukemia in Remission; Childhood Acute Myelomonocytic Leukemia (M4); Childhood Acute Promyelocytic Leukemia (M3); Childhood Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Chronic Phase Chronic Myelogenous Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; De Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-Cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent

  10. THE GREAT SOUTHERN CALIFORNIA SHAKEOUT: Earthquake Science for 22 Million People (United States)

    Jones, L.; Cox, D.; Perry, S.; Hudnut, K.; Benthien, M.; Bwarie, J.; Vinci, M.; Buchanan, M.; Long, K.; Sinha, S.; Collins, L.


    Earthquake science is being communicated to and used by the 22 million residents of southern California to improve resiliency to future earthquakes through the Great Southern California ShakeOut. The ShakeOut began when the USGS partnered with the California Geological Survey, Southern California Earthquake Center and many other organizations to bring 300 scientists and engineers together to formulate a comprehensive description of a plausible major earthquake, released in May 2008, as the ShakeOut Scenario, a description of the impacts and consequences of a M7.8 earthquake on the Southern San Andreas Fault (USGS OFR2008-1150). The Great Southern California ShakeOut was a week of special events featuring the largest earthquake drill in United States history. The ShakeOut drill occurred in houses, businesses, and public spaces throughout southern California at 10AM on November 13, 2008, when southern Californians were asked to pretend that the M7.8 scenario earthquake had occurred and to practice actions that could reduce the impact on their lives. Residents, organizations, schools and businesses registered to participate in the drill through where they could get accessible information about the scenario earthquake and share ideas for better reparation. As of September 8, 2008, over 2.7 million confirmed participants had been registered. The primary message of the ShakeOut is that what we do now, before a big earthquake, will determine what our lives will be like after. The goal of the ShakeOut has been to change the culture of earthquake preparedness in southern California, making earthquakes a reality that are regularly discussed. This implements the sociological finding that 'milling,' discussing a problem with loved ones, is a prerequisite to taking action. ShakeOut milling is taking place at all levels from individuals and families, to corporations and governments. Actions taken as a result of the ShakeOut include the adoption of earthquake

  11. A Case Study of Array-based Early Warning System for Tsunami Offshore Ventura, California (United States)

    Xie, Y.; Meng, L.


    Extreme scenarios of M 7.5+ earthquakes on the Red Mountain and Pitas Point faults can potentially generate significant local tsunamis in southern California. The maximum water elevation could be as large as 10 m in the nearshore region of Oxnard and Santa Barbara. Recent development in seismic array processing enables rapid tsunami prediction and early warning based on the back-projection approach (BP). The idea is to estimate the rupture size by back-tracing the seismic body waves recorded by stations at local and regional distances. A simplified source model of uniform slip is constructed and used as an input for tsunami simulations that predict the tsunami wave height and arrival time. We demonstrate the feasibility of this approach in southern California by implementing it in a simulated real-time environment and applying to a hypothetical M 7.7 Dip-slip earthquake scenario on the Pitas Point fault. Synthetic seismograms are produced using the SCEC broadband platform based on the 3D SoCal community velocity model. We use S-wave instead of P-wave to avoid S-minus-P travel times shorter than rupture duration. Two clusters of strong-motion stations near Bakersfield and Palmdale are selected to determine the back-azimuth of the strongest high-frequency radiations (0.5-1 Hz). The back-azimuths of the two clusters are then intersected to locate the source positions. The rupture area is then approximated by enclosing these BP radiators with an ellipse or a polygon. Our preliminary results show that the extent of 1294 square kilometers rupture area and magnitude of 7.6 obtained by this approach is reasonably close to the 1849 square kilometers and 7.7 of the input model. The average slip of 7.3 m is then estimated according to the scaling relation between slip and rupture area, which is close to the actual average dislocation amount, 8.3 m. Finally, a tsunami simulation is conducted to assess the wave height and arrival time. The errors of -3 to +9 s in arrival time

  12. Effect of chronic smoking on lens nucleus as assessed by Pentacam HR lens densitometry in young adults. (United States)

    Pekel, Gökhan; Cetin, Ebru Nevin; Acer, Semra; Yagci, Ramazan; Altintas, Seher; Ongun, Gülin Tugba


    To evaluate the effects of chronic tobacco smoking on lens nucleus by Pentacam HR lens densitometry (LD) in young adults. Prospective cross-sectional case series. Thirty subjects (23 M, 7 F) who were chronic cigarette smokers (≥10 cigarettes/day for at least 2 years) (group 1) and another 30 subjects (23 M, 7 F) who did not smoke (group 2), were included in this study. The patients were matched for age and sex between the groups. The exclusion criteria were any history of ocular surgery, any systemic disorders and any ocular diseases except for mild refractive disorders. Lens densitometry measurements were done with the Pentacam HR (Oculus, Wetzlar, Germany). The Schirmer test and pachymetry measurements were also performed. Mean age of the patients for both groups was 28.90 ± 8.20 years (range: 18-40 years). Mean lens densitometry (LD) measurements of Group 1 (chronic cigarette smoking group) were higher than those of Group 2 (control group) in all LD techniques; however only mean "peak" LD measurements showed a statistically significant difference between these two groups (Group 1: 8.67 ± 0.61, Group 2: 8.44 ± 0.70, p = 0.04). The mean Schirmer test value was 12.43 ± 5.60 mm in Group 1 and 13.00 ± 4.26 mm in Group 2 (p = 0.55). The mean central corneal thickness (CCT) value was 564.23 ± 34.61 µm in Group 1 and 550.47 ± 32.94 µm in Group 2 (p = 0.03). The Pentacam HR LD seems to be an important option for the evaluation of lens nucleus in young adults, because it gives objective and quantitative data. Although chronic smoking increases lens nucleus density in young adults, the effect is not statistically significant when compared with the control group.

  13. Predicted Liquefaction in the Greater Oakland and Northern Santa Clara Valley Areas for a Repeat of the 1868 Hayward Earthquake (United States)

    Holzer, T. L.; Noce, T. E.; Bennett, M. J.


    Probabilities of surface manifestations of liquefaction due to a repeat of the 1868 (M6.7-7.0) earthquake on the southern segment of the Hayward Fault were calculated for two areas along the margin of San Francisco Bay, California: greater Oakland and the northern Santa Clara Valley. Liquefaction is predicted to be more common in the greater Oakland area than in the northern Santa Clara Valley owing to the presence of 57 km2 of susceptible sandy artificial fill. Most of the fills were placed into San Francisco Bay during the first half of the 20th century to build military bases, port facilities, and shoreline communities like Alameda and Bay Farm Island. Probabilities of liquefaction in the area underlain by this sandy artificial fill range from 0.2 to ~0.5 for a M7.0 earthquake, and decrease to 0.1 to ~0.4 for a M6.7 earthquake. In the greater Oakland area, liquefaction probabilities generally are less than 0.05 for Holocene alluvial fan deposits, which underlie most of the remaining flat-lying urban area. In the northern Santa Clara Valley for a M7.0 earthquake on the Hayward Fault and an assumed water-table depth of 1.5 m (the historically shallowest water level), liquefaction probabilities range from 0.1 to 0.2 along Coyote and Guadalupe Creeks, but are less than 0.05 elsewhere. For a M6.7 earthquake, probabilities are greater than 0.1 along Coyote Creek but decrease along Guadalupe Creek to less than 0.1. Areas with high probabilities in the Santa Clara Valley are underlain by latest Holocene alluvial fan levee deposits where liquefaction and lateral spreading occurred during large earthquakes in 1868 and 1906. The liquefaction scenario maps were created with ArcGIS ModelBuilder. Peak ground accelerations first were computed with the new Boore and Atkinson NGA attenuation relation (2008, Earthquake Spectra, 24:1, p. 99-138), using VS30 to account for local site response. Spatial liquefaction probabilities were then estimated using the predicted ground motions

  14. Microstructure evolution and mechanical properties of X12CrMoWVNbN10-1-1 steel during quenching and tempering process

    Directory of Open Access Journals (Sweden)

    Xingang Tao


    Full Text Available The effect of heat treatments was investigated on the microstructure evolution and mechanical properties of X12CrMoWVNbN10-1-1 steel. The as-received steel was austenitized at 1080 °C for 16 h and cooled in furnace, following tempered in two steps, i.e. at 570 °C for 18 h and then at 690 °C for 24 h. The austenitized sample had a typical lath martensite structure with some retained austenite and no delta ferrite was observed after austenitization. After the first tempering at 570 °C, there was no retained austenite remained but it resulted in the forming of precipitates, such as Cr-rich M7C3, Cr-rich M23C6, Cr-rich M2N, Nb-rich MN, and the subgrain, as well as the reduction in dislocation density. However, microstructure observation after secondary tempering proved the further arrangement of dislocation, subgrain growth and the coarsening of precipitates. Hardness and impact tests were carried out for establishing a correlation between microstructure and mechanical properties. Finally, a careful fractographic analysis of impact samples had been done using SEM and EDS.

  15. Episodic slow slip events in the Japan subduction zone before the 2011 Tohoku-Oki earthquake (United States)

    Ito, Yoshihiro; Hino, Ryota; Kido, Motoyuki; Fujimoto, Hiromi; Osada, Yukihito; Inazu, Daisuke; Ohta, Yusaku; Iinuma, Takeshi; Ohzono, Mako; Miura, Satoshi; Mishina, Masaaki; Suzuki, Kensuke; Tsuji, Takeshi; Ashi, Juichiro


    We describe two transient slow slip events that occurred before the 2011 Tohoku-Oki earthquake. The first transient crustal deformation, which occurred over a period of a week in November 2008, was recorded simultaneously using ocean-bottom pressure gauges and an on-shore volumetric strainmeter; this deformation has been interpreted as being an M6.8 episodic slow slip event. The second had a duration exceeding 1 month and was observed in February 2011, just before the 2011 Tohoku-Oki earthquake; the moment magnitude of this event reached 7.0. The two events preceded interplate earthquakes of magnitudes M6.1 (December 2008) and M7.3 (March 9, 2011), respectively; the latter is the largest foreshock of the 2011 Tohoku-Oki earthquake. Our findings indicate that these slow slip events induced increases in shear stress, which in turn triggered the interplate earthquakes. The slow slip event source area on the fault is also located within the downdip portion of the huge-coseismic-slip area of the 2011 earthquake. This demonstrates episodic slow slip and seismic behavior occurring on the same portions of the megathrust fault, suggesting that the faults undergo slip in slow slip events can also rupture seismically.

  16. Physical properties and organic carbon content of a Rhodic Kandiudox fertilized with pig slurry and poultry litter

    Directory of Open Access Journals (Sweden)

    Luiz Paulo Rauber


    Full Text Available The impact of pig slurry and poultry litter fertilization on soils depends on the conditions of use and the amounts applied. This study evaluated the effect of organic fertilizers after different application periods in different areas on the physical properties and organic carbon contents of a Rhodic Kandiudox, in Concordia, Santa Catarina, in Southern Brazil. The treatments consisted of different land uses and periods of pig and poultry litter fertilization: silage maize (M7 years, silage maize (M20 years, annual ryegrass pasture (P3 years, annual ryegrass pasture (P15 years, perennial pasture (PP20 years, yerba mate tea (Mt20 years, native forest (NF, and native pasture without manure application (P0. The 0-5, 5-10 and 10-20 cm soil layers were sampled and analyzed for total organic carbon, total nitrogen and soil physical properties such as density, porosity, aggregation, degree of flocculation, and penetration resistance. The organic carbon levels in the cultivated areas treated with organic fertilizer were even lower than in native forest soil. The organic fertilizers and studied management systems reduced the flocculation degree of the clay particles, and low macroporosity was observed in some areas. Despite these changes, a good soil physical structure was maintained, e.g., soil density and resistance to penetration were below the critical limits, whereas aggregate stability was high, which is important to reduce water erosion in these areas with rugged terrain in western Santa Catarina, used for pig and poultry farming.

  17. Design and motion control of bioinspired humanoid robot head from servo motors toward artificial muscles (United States)

    Almubarak, Yara; Tadesse, Yonas


    The potential applications of humanoid robots in social environments, motivates researchers to design, and control biomimetic humanoid robots. Generally, people are more interested to interact with robots that have similar attributes and movements to humans. The head is one of most important part of any social robot. Currently, most humanoid heads use electrical motors, pneumatic actuators, and shape memory alloy (SMA) actuators for actuation. Electrical and pneumatic actuators take most of the space and would cause unsmooth motions. SMAs are expensive to use in humanoids. Recently, in many robotic projects, Twisted and Coiled Polymer (TCP) artificial muscles are used as linear actuators which take up little space compared to the motors. In this paper, we will demonstrate the designing process and motion control of a robotic head with TCP muscles. Servo motors and artificial muscles are used for actuating the head motion, which have been controlled by a cost efficient ARM Cortex-M7 based development board. A complete comparison between the two actuators is presented.

  18. Antibacterial and Anticandidal Activities of Common Essential Oil Constituents

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    Gökalp İşcan


    Full Text Available Essential oils and some of their oxygenated constituents are known to possess antimicrobial activity. In the last 30 years, there is a dramatic increase in the number of resistant microorganisms against available antimicrobials and a tendency towards natural products; consequently, scientists have been forced to discover new bioactive agents preferably from nature. As a result of this, so many antimicrobial screening works have been published on plant essential oils including miscellaneous screening methods and several microorganism strains. The aim of this study was to determine the MIC values of 65 monoterpenoids and 3 phenyl propanoids commonly found in essential oils, against 24 pathogenic bacteria and Candida strains, by using standard reference broth dilution methods (CLSI M7-A7 and M27-A2. According to broth microdilution test results, when compared with standard agents, monoterpene hydrocarbons generally showed weak antibacterial effects (>16 to 4 mg/mL where the oxygenated monoterpenes inhibited the microbial growth between the concentrations of 16 to 0,03 mg/mL. Generally, tested compounds demonstrated better inhibitory effects on Candida strains then the bacteria panel. The most effective microbial growth inhibitor constituents were determined as carvacrol, thymol, cumin alcohol, terpinen-4-ol, α-terpineol, lavandulol, estragol and thymoquinone.

  19. The eclipsing AM Herculis star 2A 0311 - 227

    International Nuclear Information System (INIS)

    Allen, D.A.; Wright, A.E.; Ward, M.J.


    Infrared photometry and optical spectrophotometry of the AM Herculis star 2A 0311 - 227 are described. In its 81-min orbit there are two eclipses at infrared wavelengths and a third, intermittent eclipse of the optical emission lines. One of these eclipses is caused by an M dwarf which orbits a magnetic white dwarf. Much of the geometry of the system can be specified. An inclination near 80 0 is found, and a mass of the M dwarf which corresponds to a spectral type of M7 or M8. Accretion appears to occur on to two magnetic poles of the white dwarf, but the field strengths differ so that one pole emits preferentially at optical wavelengths and the other mostly in the infrared. The location of the redder-emitting magnetic pole can be specified because of its eclipse by the white dwarf, but there remains some uncertainty in the location of the bluer pole. All interpretations seem to require that the magnetic poles are not symmetrically disposed about the white dwarf, and some evidence suggests that like poles are less than 60 0 apart. (author)

  20. Analysis of low-frequency climate periodicity in lacustrine sediments from the Enciso Group (Lower Cretaceous, Cameros basin, La Rioja, Spain) and its application to the correlation and dating of the series; Analisis de la periodicidad climatica de baja frecuencia registrada en los sedimentos lacustres del Grupo Enciso (Cretacico Inferior de la cuenca de Cameros, La Rioja): Aplicaciones a la correlacion y datacion de la serie

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    Angulo, A.; Munoz, A.


    We have characterized seven facies linked to three sedimentary environments: distal riverine, siliciclastic lacustrine and carbonate lacustrine, in the Lower Cretaceous syn-rift deposits in the Cameros basin (Enciso Group). The analysis was conducted on a 996-metre-thick series consisting of 74 sedimentary cycles. The facies were analysed using the Markov chains method. We identified three type-sequences linked to the recognised sedimentary environments. By studying the relationships between the facies we were able to develop a sedimentological model, with the relative position of each facies related to the lake shoreline. From this model we could construct a time series based on semi-quantitative depth (depth rank) and analyse it with the Wavelet and REDFIT programs. Spectral analysis identified periodic sedimentary cycles comparable to Milankovitch frequencies. The results show power-spectrum maxima (confidence level >99%) at 90.56 m, 16.66 m, 7.14 m, 5.37 m and 3.93 m. The sedimentary cycle interpreted as short eccentricity (16.66 m) is the most easily identifiable in the outcrop and constitutes the basis of our sequential analysis.