WorldWideScience

Sample records for m2 surface plots

  1. Study on Surface Plotting Methods in Parts Plotting

    Institute of Scientific and Technical Information of China (English)

    LIU Zhen; ZHAO Fa-dong

    2013-01-01

    According to the factors that confirm the shape of surface, it is classified into two categories:arc surface and curve surface. The method to confirm the category of surfaces and the plotting methods are discussed in this paper, which provide guidance for parts plotting.

  2. Fermi surface behavior in the ABJM M2-brane theory

    Science.gov (United States)

    DeWolfe, Oliver; Henriksson, Oscar; Rosen, Christopher

    2015-06-01

    We calculate fermionic Green's functions for states of the three-dimensional Aharony-Bergman-Jafferis-Maldacena M2-brane theory at large N using the gauge-gravity correspondence. We embed extremal black brane solutions in four-dimensional maximally supersymmetric gauged supergravity, obtain the linearized Dirac equations for each spin-1 /2 mode that cannot mix with a gravitino, and solve these equations with infalling boundary conditions to calculate retarded Green's functions. For generic values of the chemical potentials, we find Fermi surfaces with universally non-Fermi liquid behavior, matching the situation for four-dimensional N =4 super-Yang-Mills. Fermi surface singularities appear and disappear discontinuously at the point where all chemical potentials are equal, reminiscent of a quantum critical point. One limit of parameter space has zero entropy at zero temperature, and fermionic fluctuations are perfectly stable inside an energy region around the Fermi surface. An ambiguity in the quantization of the fermions is resolved by supersymmetry.

  3. Assessing topsoil and bedrock hydrodynamic properties from natural and artificial rainfalls over a 10m2 steep plot in Cevennes area (France)

    Science.gov (United States)

    Adamovic, Marko; Bouvier, Christophe; Brunet, Pascal; Ayral, Pierre-Alain

    2016-04-01

    Flash floods are feature of Mediterranean climate characterized by heavy rainfalls in a few hours. Hydrological processes depend on both the topsoil and bedrock properties, which are still poorly known in the mountainous areas. Thus, special attention was paid to characterize the water fluxes in the shallow near-surface area. This study focuses on a 10-m2plot within a granitic hillslope in Cevennes area. Water content was monitored at several depths (up to 70cm) during both intense artificial and natural rainfall events, in order to study both infiltration and saturation processes in both extreme and normal conditions. Inverse modeling was performed in order to estimate parameters, such as θs, θr, α, n, Ks associated to the Mualem-Van Genuchten formulation, using the HYDRUS-1D software. The deep boundary condition was also calibrated to assess the properties of the deep layers. Although the topsoil depth is rather small (˜40 cm), the water storage during the rainfalls was estimated to be some hundreds millimeters, which largely exceeds the topsoil capacity. It suggests that the weathered area (and maybe the fractured rock area) below the soil, can have an active role in the water storage and sub-surface flow dynamics. Similar parameters were used to perform correct simulations under both artificial and natural rainfalls: thus artificial rainfalls enhance extreme conditions corresponding to flash floods occurrence, and the identified flux patterns are robust in natural conditions.

  4. Chemotherapy toxicity in gynecologic cancer patients with a body surface area (BSA)>2 m2.

    Science.gov (United States)

    Schwartz, Joanna; Toste, Beth; Dizon, Don S

    2009-07-01

    Although many clinicians practice empiric dose reduction to prevent toxicity, it is unknown whether obese patients given chemotherapy dosed according to actual body weight (ABW) experience excess toxicity. At our institution, cancer patients receive chemotherapy dosed by ABW unless on a protocol capping doses at a maximum body surface area (BSA). We compared toxicities and dose modifications between women with a BSA>2 m(2) on uncapped versus capped paclitaxel as part of adjuvant paclitaxel/carboplatin for gynecologic malignancy. In this retrospective study, women with a BSA>2 m(2) treated with paclitaxel (P) and carboplatin (C) for endometrial and ovarian cancer between January 1999 and July 2007 were identified using the chemotherapy database. Records were reviewed for patient age, BSA, diagnosis, stage, standardized and actual doses for each cycle, adverse drug reactions, and dosing modifications. Statistical comparisons were made using Fisher's exact test. We identified 59 women with BSA>2 m(2) on adjuvant P/C for endometrial and ovarian cancers. 50 received paclitaxel dosed by ABW and 9 received paclitaxel capped at a BSA of 2 m(2). There were no statistically significant differences in rates of toxicity or dose modification. Obese women with a BSA>2 m(2) on paclitaxel dosed by ABW do not experience excess toxicity in comparison to women on paclitaxel capped at a maximum BSA or women in published trials of adjuvant P/C. Empiric dose reduction is unnecessary and may result in suboptimal treatment of obese patients. However, as this was a retrospective review, more research is needed to make definitive recommendations on this topic.

  5. Studying randomness and determinism in surface temperature anomaly indices using the recurrence plot method

    Science.gov (United States)

    Kiselev, B. V.

    2016-01-01

    Surface temperature anomalies are studied using the methods of recurrence plots and statistical R/S analysis, as well as the Higuchi method for determining fractal dimension. Anomalies of the surface temperature above continents and the temperature in the World Ocean regions and in the Northern and Southern hemispheres are considered independently. It has been indicated that anomalies are more stochastic and deterministic for land and ocean surfaces, respectively.

  6. Plot-scale field experiment of surface hydrologic processes with EOS implications

    Science.gov (United States)

    Laymon, Charles A.; Macari, Emir J.; Costes, Nicholas C.

    1992-01-01

    Plot-scale hydrologic field studies were initiated at NASA Marshall Space Flight Center to a) investigate the spatial and temporal variability of surface and subsurface hydrologic processes, particularly as affected by vegetation, and b) develop experimental techniques and associated instrumentation methodology to study hydrologic processes at increasingly large spatial scales. About 150 instruments, most of which are remotely operated, have been installed at the field site to monitor ground atmospheric conditions, precipitation, interception, soil-water status, and energy flux. This paper describes the nature of the field experiment, instrumentation and sampling rationale, and presents preliminary findings.

  7. A Global Map of Coherent M2 Internal Tide Surface Elevations

    Science.gov (United States)

    Ray, R. D.; Zaron, E. D.

    2014-12-01

    Satellite altimetry reveals small surface waves, with elevations of order 1 cm or smaller, associated with internal tides in the deep ocean. The global satellite data provide an unprecedented picture of such waves, potentially yielding much information about the ocean interior. Accurate knowledge of these waves is also needed for de-tiding altimetry in certain sensitive applications, including the future SWOT mission. Several approaches have been initiated recently to map these tiny waves, usually with some reliance on hydrographic information (e.g., recent work by Dushaw et al., 2011). Here we explore the feasibility of a purely empirical approach which avoids assumptions about stratification or modal wavelengths. A global elevation map is constructed based on tidal analysis of Topex/Poseidon, Jason, ERS-2, Envisat and GFO data. Small (order 5 mm) residuals, with wavelengths much longer than the baroclinic tide, appear unless now-standard along-track high-pass filters are applied, but filtering is shown to cause serious loss of information for east-west propagating waves (given typical track patterns). The technique is probably infeasible for S2 because of Envisat's and ERS's sun-synchronous orbits. Independent data from Cryosat-2 is used to validate the results. Applying our internal-tide 'correction' to Cryosat-2 data confirms a small reduction in variance in expected locations of significant internal tides.

  8. The surface accessibility of the glycine receptor M2-M3 loop is increased in the channel open state.

    Science.gov (United States)

    Lynch, J W; Han, N L; Haddrill, J; Pierce, K D; Schofield, P R

    2001-04-15

    Mutations in the extracellular M2-M3 loop of the glycine receptor (GlyR) alpha1 subunit have been shown previously to affect channel gating. In this study, the substituted cysteine accessibility method was used to investigate whether a structural rearrangement of the M2-M3 loop accompanies GlyR activation. All residues from R271C to V277C were covalently modified by both positively charged methanethiosulfonate ethyltrimethylammonium (MTSET) and negatively charged methanethiosulfonate ethylsulfonate (MTSES), implying that these residues form an irregular surface loop. The MTSET modification rate of all residues from R271C to K276C was faster in the glycine-bound state than in the unliganded state. MTSES modification of A272C, L274C, and V277C was also faster in the glycine-bound state. These results demonstrate that the surface accessibility of the M2-M3 loop is increased as the channel transitions from the closed to the open state, implying that either the loop itself or an overlying domain moves during channel activation.

  9. Identification of a Segment of the Yield Surface of a Two-Layer Pa38/M2R Composite

    Science.gov (United States)

    Uscinowicz, R. R.

    2016-05-01

    The aim of this study was to identify the initial yield surface of a two-layer aluminum alloy-copper composite in the range of small elastic-plastic deformations. Experimental tests in a plane stress state were conducted by loading tubular composite specimens with various combinations of axial forces and torque. The metal layers were joined together by using an epoxy resin. Independent studies were carried out for component of the composite under identical conditions. The yield surfaces obtained were compared with those given by the Huber-von Mises-Hencky and Tresca-Guest yield criteria. The yield criterion for the tested composite found by using a modified form of the rule of mixtures is presented. The yield surfaces of a Pa38/M2R composite and its components demonstrated the isotropic hardening.

  10. Dynamical characteristics of surface EMG signals of hand grasps via recurrence plot.

    Science.gov (United States)

    Ouyang, Gaoxiang; Zhu, Xiangyang; Ju, Zhaojie; Liu, Honghai

    2014-01-01

    Recognizing human hand grasp movements through surface electromyogram (sEMG) is a challenging task. In this paper, we investigated nonlinear measures based on recurrence plot, as a tool to evaluate the hidden dynamical characteristics of sEMG during four different hand movements. A series of experimental tests in this study show that the dynamical characteristics of sEMG data with recurrence quantification analysis (RQA) can distinguish different hand grasp movements. Meanwhile, adaptive neuro-fuzzy inference system (ANFIS) is applied to evaluate the performance of the aforementioned measures to identify the grasp movements. The experimental results show that the recognition rate (99.1%) based on the combination of linear and nonlinear measures is much higher than those with only linear measures (93.4%) or nonlinear measures (88.1%). These results suggest that the RQA measures might be a potential tool to reveal the sEMG hidden characteristics of hand grasp movements and an effective supplement for the traditional linear grasp recognition methods.

  11. Glass mirrors by cold slumping to cover 100 m2 of the MAGIC II Cherenkov telescope reflecting surface

    Science.gov (United States)

    Pareschi, G.; Giro, E.; Banham, R.; Basso, S.; Bastieri, D.; Canestrari, R.; Ceppatelli, G.; Citterio, O.; Doro, M.; Ghigo, M.; Marioni, F.; Mariotti, M.; Salvati, M.; Sanvito, F.; Vernani, D.

    2008-07-01

    We report on the production and implementation of 100 square panels 1 m x 1 m, based on the innovative approach of cold slumping of thin glass sheets. The more than 100 segments will cover around one half of the 240 m-square reflecting surface of the MAGIC II, a clone of the atmospheric Cherenkov telescope MAGIC I (with a single-dish 17 m diameter mirror) which is already operating since late 2003 at La Palma. The MAGIC II telescope will be completed by the end of 2008 and will operate in stereoscopic mode with MAGIC I. While the central part of the of the reflector is composed of by diamond milled Aluminum of 1m2 area panels (following a design similar to that already used for MAGIC I), the outer coronas will be made of sandwiched glass segments. The glass panel production foresees the following steps: a) a thin glass sheet (1-2mm) is elastically deformed so as to retain the shape imparted by a master with convex profile - the radius of curvature is large, the sheet can be pressed against the master using vacuum suction -; b) on the deformed glass sheet a honeycomb structure that provides the needed rigidity is glued ; c) then a second glass sheet is glued on the top in order to obtain a sandwich; d) after on the concave side a reflecting coating (Aluminum) and a thin protective coating (Quartz) are deposited. The typical weight of each panel is about 12 kg and its resolution is better than 1 mrad at a level of diameter that contains the 90% of the energy reflected by the mirror; the areal cost of glass panels is ~2 k per 1m2. The technology based on cold slumping is a good candidate for the production of the primary mirrors of the telescopes forming the Cherenkov Telescope Array (CTA), the future large TeV observatory currently being studied in Europe. Details on the realization of MAGIC II new mirrors based on cold slumping glass will be presented.

  12. Characterization of Surface Runoff, Soil Erosion, Nutrient Loss and their relationship for Agricultural plots in India

    Directory of Open Access Journals (Sweden)

    Mohan La

    2015-08-01

    Full Text Available The present study was carried out to explore the existence of relationship among rainfall, runoff, soil loss and nutrient losses from the agricultural plots located at Roorkee, Uttarakhand, India. The natural rainfall generated runoff and soil loss from the 12 agricultural runoff plots (with four land uses namely sugarcane, maize, black gram and fallow land and having slope 5%, 3% and 1% for each land use were recorded during monsoon period (June 2013 to September 2013. The highest grade plot was found to yield the highest magnitude of runoff (i.e. runoff coefficient for a given land use and soil type. The soil loss from the experimental plots of various characteristics shown that for given rainfall input, on average, the plots with sugarcane land use were found to produce high amount of soil loss followed by Maize, fallow land and Blackgram. The nutrients losses were very low in the sediment as compared to the dissolved losses. Nutrients concentrations in sediment and runoff water were found to be more during the critical period. The higher limit of seasonal sediment yield obtained from the present study is lower than soil loss tolerance limit of 2.5 to 12.5 t/ha /yr for Indian subcontinent.

  13. Application of GPS and Near-Surface Geophysical Methods to Evaluate Agricultural Test Plot Differences

    Science.gov (United States)

    A field research facility with two pairs of replicated agricultural test plots (four total) was established at a location in northwest Ohio during 2005 for the purpose of studying water table management strategies. Initial efforts at this field research facility were devoted to evaluating difference...

  14. Surface stabilization and revegetation test plots. Fiscal year 1993 status report

    Energy Technology Data Exchange (ETDEWEB)

    Sackschewsky, M.R.; Kemp, C.J.; Hayward, W.M.

    1993-09-01

    Westinghouse Hanford Company Decommissioning and Decontamination Engineering Group and Environmental Technology and Assessment Groups are developing new technologies to improve revegetation techniques for interim stabilization control over underground waste sites within the Radiation Area Remedial Action Program. Successful revegetation is an integral aspect of waste isolation strategy. Unfortunately, revegetation can be very difficult to achieve on the Hanford Site due to several factors: low annual precipitation, unpredictable timing of precipitation, low fertility of available soils, and coarse physical texture of soils covering waste sites. The tests in this report were performed during fiscal years 1992 and 1993 and include the use of two soil sealants in combination with bare soil and a soil/compost mixture and a comparison of a wheatgrass mixture and a native seed mixture. Hydroprobe access ports were placed in one-half of the test plots and moisture data was collected. Soil fertility and plant community characteristics were monitored during the two years of the test. During the first year all sites with compost provided additional fertility and retained greater amounts of soil moisture than noncomposted sites. The use of Enduraseal soil fixative provided greater soil moisture than the use of Aerospray-77 soil fixative. During the second year the use of compost and soil fixative`s had a lesser effect on soil moisture. During late summer periods all treatments had very similar soil moisture profiles. The use of compost greatly increased vegetative cover and soil fertility in comparison to sites that had no compost added. Testing of the seed mixtures found that Siberian wheatgrass and Sandberg`s bluegrass were the most dominant of the seeded species observed. All plots exhibited a dominant plant cover of volunteer cheatgrass. Biomass production was significantly greater on plots with compost than on the noncomposted plots.

  15. Classes of Split-Plot Response Surface Designs for Equivalent Estimation

    Science.gov (United States)

    Parker, Peter A.; Kowalski, Scott M.; Vining, G. Geoffrey

    2006-01-01

    When planning an experimental investigation, we are frequently faced with factors that are difficult or time consuming to manipulate, thereby making complete randomization impractical. A split-plot structure differentiates between the experimental units associated with these hard-to-change factors and others that are relatively easy-to-change and provides an efficient strategy that integrates the restrictions imposed by the experimental apparatus. Several industrial and scientific examples are presented to illustrate design considerations encountered in the restricted randomization context. In this paper, we propose classes of split-plot response designs that provide an intuitive and natural extension from the completely randomized context. For these designs, the ordinary least squares estimates of the model are equivalent to the generalized least squares estimates. This property provides best linear unbiased estimators and simplifies model estimation. The design conditions that allow for equivalent estimation are presented enabling design construction strategies to transform completely randomized Box-Behnken, equiradial, and small composite designs into a split-plot structure.

  16. Analysis and modelling of the temporal stability of throughfall and near-surface soil moisture at the plot scale in the Italian pre-Alps

    Science.gov (United States)

    Zuecco, Giulia; van Meerveld, Ilja; Penna, Daniele; Hopp, Luisa; Borga, Marco

    2016-04-01

    Understanding the spatial and temporal variation in soil moisture at different scales is crucial for hydrological sciences. In forested areas, spatial patterns in throughfall and vegetation characteristics are expected to control soil moisture variability. However, few studies have focused on the influence of throughfall spatial patterns on near-surface soil moisture. Therefore, this study aimed to: i) investigate the relation between the spatial patterns of throughfall and near-surface soil moisture at the plot scale for a forested hillslope, ii) compare the temporal stability of throughfall and soil moisture with canopy characteristics, and iii) assess the controls on the correlation between throughfall and soil moisture temporal stability by means of a dynamic soil moisture model. Throughfall and soil moisture measurements were taken in a 500 m2 experimental plot on the hillslope of a densely forested catchment (Ressi) in the Italian pre-Alps between April 2013 and March 2014. The main tree species in the plot are beech and chestnut. The median diameter at breast height of the trees in the plot is 4 cm (range 1-61 cm). Fifty buckets (collecting area: 556 cm2; capacity: 162 mm) were randomly distributed in the plot for throughfall measurements, while a bucket was also installed in a nearby open area (approximately 150 m from the experimental plot) to collect rainfall. Volumetric soil moisture content was measured at 50 points, about 30 cm upslope of each bucket, at two depths (0-7 and 0-12 cm) before and after 23 rainfall events (7.7 mm to 156 mm) using portable TDR (Time Domain Reflectivity) probes. Canopy openness and leaf area index (LAI) were determined from hemispherical pictures at each bucket. For the measured events throughfall and soil moisture spatial patterns were not significantly or only weakly correlated, likely due to the lateral and vertical redistribution of water in the soil profile during the 2-36 hour period between the end of the rainfall

  17. Height estimate for special Weingarten surfaces of elliptic type in ${\\mathbb M}^2(c \\times \\mathbb {R}$

    Directory of Open Access Journals (Sweden)

    Filippo Morabito

    2014-01-01

    Full Text Available In this article we provide a vertical height estimate for compact special Weingarten surfaces of elliptic type in ²(×ℝ, i.e. surfaces whose mean curvature ℍ and extrinsic Gauss curvature ₑ satisfy ℍ=(ℍ²-ₑ with 4(’(²<1, for all ∈[0,+∞. The vertical height estimate generalizes a result by Rosenberg and Sa Earp and applies only to surfaces verifying a height estimate condition. When <0, using also a horizontal height estimate, we show a non-existence result for properly embedded Weingarten surfaces of elliptic type in ℍ²(×ℝ with finite topology and one end.

  18. Hierarchical bioceramic scaffolds with 3D-plotted macropores and mussel-inspired surface nanolayers for stimulating osteogenesis

    Science.gov (United States)

    Xu, Mengchi; Zhai, Dong; Xia, Lunguo; Li, Hong; Chen, Shiyi; Fang, Bing; Chang, Jiang; Wu, Chengtie

    2016-07-01

    The hierarchical structure of biomaterials plays an important role in the process of tissue reconstruction and regeneration. 3D-plotted scaffolds have been widely used for bone tissue engineering due to their controlled macropore structure and mechanical properties. However, the lack of micro- or nano-structures on the strut surface of 3D-plotted scaffolds, especially for bioceramic scaffolds, limits their biological activity. Inspired by the adhesive versatility of mussels and the active ion-chelating capacity of polydopamine, we set out to prepare a hierarchical bioceramic scaffold with controlled macropores and mussel-inspired surface nanolayers by combining the 3D-plotting technique with the polydopamine/apatite hybrid strategy in order to synergistically accelerate the osteogenesis and angiogenesis. β-Tricalcium phosphate (TCP) scaffolds were firstly 3D-plotted and then treated in dopamine-Tris/HCl and dopamine-SBF solutions to obtain TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds, respectively. It was found that polydopamine/apatite hybrid nanolayers were formed on the surface of both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds and TCP-DOPA-SBF scaffolds induced apatite mineralization for the second time during the cell culture. As compared to TCP scaffolds, both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds significantly promoted the osteogenesis of bone marrow stromal cells (BMSCs) as well as the angiogenesis of human umbilical vein endothelial cells (HUVECs), and the TCP-DOPA-SBF group presented the highest in vitro osteogenic/angiogenic activity among the three groups. Furthermore, both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds significantly improved the formation of new bone in vivo as compared to TCP scaffolds without a nanostructured surface. Our results suggest that the utilization of a mussel-inspired Ca, P-chelated polydopamine nanolayer on 3D-plotted bioceramic scaffolds is a viable and effective strategy to construct a hierarchical structure for synergistically

  19. Plot 3

    DEFF Research Database (Denmark)

    Lund, Inger-Lise; Gjessing, Susanne; Hermansen, Anne-Mette

    Plot 3 er første udgivelse af et alsidigt dansksystem til mellemtrinnet, hvor digitale medier er integreret i den daglige undervisning.......Plot 3 er første udgivelse af et alsidigt dansksystem til mellemtrinnet, hvor digitale medier er integreret i den daglige undervisning....

  20. Plot 3

    DEFF Research Database (Denmark)

    Lund, Inger-Lise; Gjessing, Susanne; Hermansen, Anne-Mette

    Plot 3 er første udgivelse af et alsidigt dansksystem til mellemtrinnet, hvor digitale medier er integreret i den daglige undervisning.......Plot 3 er første udgivelse af et alsidigt dansksystem til mellemtrinnet, hvor digitale medier er integreret i den daglige undervisning....

  1. Plot 4

    DEFF Research Database (Denmark)

    Lund, Inger-Lise; Hermansen, Anne-Mette; Ferdinand, Trine

    Danskfaglig vejledning informerer om de tanker, der ligger til grund for Plot 4, og beskriver danskfaget ud fra nyere forskning inden for fagets mange delområder. Kapitelvejledning introducerer bogens tekster, forklarer hensigten med kapitlernes opgaver, giver forslag til undervisningen og brugen...

  2. Plot 5

    DEFF Research Database (Denmark)

    Lund, Inger-Lise; Hermansen, Anne-Mette; Ferdinand, Trine

    Danskfaglig vejledning informerer om de tanker, der ligger til grund for Plot 5, og beskriver danskfaget ud fra nyere forskning inden for fagets mange delområder. Kapitelvejledning introducerer bogens tekster, forklarer hensigten med kapitlernes opgaver, giver forslag til undervisningen og brugen...

  3. Plotting Conflict.

    Science.gov (United States)

    Wilkinson, Margaret Ann; Wilkinson, John Provost

    1997-01-01

    Conflict management theory is illustrated in a series of hypothetical scenarios, typical of library situations. Each scenario is discussed in terms of a specific management theory and the theories are transposed into useful management tools by plotting each situation along relevant axes. (Author/AEF)

  4. Plot 5

    DEFF Research Database (Denmark)

    Lund, Inger-Lise; Hermansen, Anne-Mette; Ferdinand, Trine

    Danskfaglig vejledning informerer om de tanker, der ligger til grund for Plot 5, og beskriver danskfaget ud fra nyere forskning inden for fagets mange delområder. Kapitelvejledning introducerer bogens tekster, forklarer hensigten med kapitlernes opgaver, giver forslag til undervisningen og brugen...

  5. Use of postmortem temperature decay response surface plots of heat transport in the human eye to predict time of death.

    Science.gov (United States)

    Smart, Jimmy L

    2014-03-01

    A finite element heat transfer model of the human eye was previously constructed and applied to experimental postmortem temperature decay curves collected in eyeballs of ten human bodies. The model was applied in the early postmortem period of 0–24 h under conditions of natural convection–radiation. Based upon this previous model, response surfaces for postmortem temperature decay were constructed based upon variable ranges of the natural convective–radiation heat transfer coefficient from 7–13 W/m2 K, ambient temperatures of 10–33°C, and times of 0–24 h. Mathematical equations to describe these response surfaces have been developed. This response surface method is demonstrated for use by coroners/medical personnel to estimate time of death from recorded field temperature data collected over a 30-min period. Sensitivity of the model to small changes in the key variable of ambient temperature is explored. The response surface model is applied to two cases of previously collected experimental eyeball temperature data. This response surface model method is only valid for constant surrounding temperatures, conditions of natural convection, no radiation effects, and postmortem times of 0–24 h.

  6. The Plot

    OpenAIRE

    Clark, J. Kent

    1991-01-01

    The following essay on the Popish Plot is chapter nine of my biography of Thomas, 5th Baron, 1st Earl, and 1st Marquess of Wharton; and perhaps it is the only chapter in the history of biography that barely mentions the name of the protagonist. This odd state of affairs arises because neither the political career of Thomas Wharton, who later became de facto prince of the Whigs, nor the English Revolution, which he vigorously supported, can be understood without considerable bac...

  7. Influence of vegetation, soil and antecedent soil moisture on the variability of surface runoff coefficients at the plot scale in the eastern alps

    Science.gov (United States)

    Chifflard, P.; Kohl, B.; Markart, G.; Kirnbauer, R.

    2009-04-01

    Modelling the runoff of a catchment in a high spatial resolution, you need to know the potential of a single plot to generate surface runoff. The portion of surface runoff is highly significant for storm runoff events, accordingly, it mainly forms the hydrograph. In this study, the influence of vegetation, soil features and antecedent soil moisture on generating surface runoff at the plot scale have been analysed. To achieve an appropriate fit of the plots, a plot sizes between 50 and 400 m² were chosen. The rainfall intensities ranged between 10 mm/h and 100 mm/h. Based on 260 rain simulations with a transportable sprinkling instrumentation on representative plots in the eastern Alps (Austria, Italy, Germany), including investigations on land-use, vegetation cover and soil physical characteristics, various soil-vegetation complexes and their surface runoff processes have been be analysed. Additionally, we investigated flow paths, travel distance, infiltration hindrance, flow resistance and overland flow velocity. The soil water status was monitored by using TDR-probes, which had been installed in two profiles within the plot in different depths ranging from 5 cm to 40 cm. For every sprinkling experiment, a surface runoff coefficient was calculated as the ratio between total rainfall amount and surface runoff. With this substantial dataset, the regression analysis was used to examine the influence of the hydrological key factors as soil, vegetation and initial soil moisture condition on the distribution functions of the surface runoff coefficient. The first results show that the vegetation cover is very important for the surface runoff. If initial soils are covered by alpine or sub-alpine pioneering vegetation surface runoff can be found very scarce. If these initial soils are covered i.e. by subalpine nardus grasslands the surface runoff coefficients range from 0.1 up to 0.8. On the other hand it can be shown that soils with a high bulk density mainly generate

  8. Complexity Plots

    KAUST Repository

    Thiyagalingam, Jeyarajan

    2013-06-01

    In this paper, we present a novel visualization technique for assisting the observation and analysis of algorithmic complexity. In comparison with conventional line graphs, this new technique is not sensitive to the units of measurement, allowing multivariate data series of different physical qualities (e.g., time, space and energy) to be juxtaposed together conveniently and consistently. It supports multivariate visualization as well as uncertainty visualization. It enables users to focus on algorithm categorization by complexity classes, while reducing visual impact caused by constants and algorithmic components that are insignificant to complexity analysis. It provides an effective means for observing the algorithmic complexity of programs with a mixture of algorithms and black-box software through visualization. Through two case studies, we demonstrate the effectiveness of complexity plots in complexity analysis in research, education and application. © 2013 The Author(s) Computer Graphics Forum © 2013 The Eurographics Association and Blackwell Publishing Ltd.

  9. Modification of AISI M2 high speed tool steels after laser surface melting under different operation conditions; Modificacion de los aceros rapidos de herramientas AISI M2 por fusion superficial con laser bajo diferentes condiciones de operacion

    Energy Technology Data Exchange (ETDEWEB)

    Arias, J.; Cabeza, M.; Castro, G.; Feijoo, I.; Merino, P.; Pena, G.

    2010-07-01

    We applied a laser surface melting treatment to AISIM2 high-speed steel hardened and tempered- and studied the resulting surface characteristics (microstructure) and mechanical behavior (hardness and wear performance). The steel was treated using a Nd:YAG continuous-wave laser with different operation conditions. The influence of the laser processing parameters on the single tracks and on melted surface layer obtained by multipass system with 50% overlap were studied. The microstructure for all conditions is formed by MC- and M{sub 2}C-type carbides, martensite and retained austenite; the quantities of this phase depends on the operations conditions. It has been determined that low levels of power density and high speed scanning of the beam leads to greater homogeneity in the microstructure with high hardness values and wear resistance. (Author) 26 refs.

  10. Factors Influencing Microbial Carbon Emission Potential from Wetland Sediments and its Relation to Surface- and Plot-Scale Measurements

    Science.gov (United States)

    Brooker, M.; Bohrer, G.; Mouser, P. J.

    2012-12-01

    Wetlands provide valuable ecosystem services by sequestering carbon dioxide from the atmosphere and serving as a sink for atmospheric nitrogen export. They are often constructed as buffers between agriculture lands and drainage channels to improve runoff water quality from elevated nutrient loading (e.g. nitrate-N). Unfortunately, carbon sequestration and denitrification in wetlands come with the tradeoff of increased production of methane, another more potent green house gas. Existing models correlate methane emission rates to increased temperature; however, surface- and plot-scale measurements show little or weak relationships between these factors at the field scale. This study examines the relationship of several environmental factors - temperature, zone location, and microbial community - to methane emissions under controlled laboratory conditions. Water and sediments collected from two depths (0-6" and 6-12") and four distinct biomes (open water and three distinct emergent macrophyte covers) were used to prepare anaerobic microcosms at two different temperatures (20°C and 30°C). Headspace gas (methane, carbon dioxide), water chemistry, and microbial community composition were analyzed over the course of several months. We observed: 1) an increase in methane emission potential with higher temperature; 2) higher levels of methane produced from shallower sediments; 3) differential production of methane versus carbon dioxide depending upon biome; and 4) variations in bacterial and archaeal diversity relating to methane production rates. This data helps provide upper limit estimates for methane emissions from wetlands by methanogenic Archaea and informs our ability to better parameterize biogeochemical and atmospheric models of these systems.

  11. The M2 Channel

    DEFF Research Database (Denmark)

    Santner, Paul

    and inhibition mechanisms, drug design studies were recently able to achieve successes in finding new potent inhibitors, some of which are even able to inhibit resistant M2 variants. Effective and robust methods for measuring M2 activity on the other hand are still scarce and tactics to assess the genetic...... barrier of new inhibitors as well as resistance development non-existent. Therefore we developed a fluorescence sensor based assay that directly measures proton conduction (pHlux assay) and combined it with an already established directed evolution selection and screening system of M2 to identify possible...... resistance escape routes from drug inhibition. We thereby were hopefully able to provide a platform for the large-scale evaluation of M2 channel activity, inhibitors and resistance....

  12. Orbital Plots Using Gnuplot

    Science.gov (United States)

    Moore, Brian G.

    2000-06-01

    The plotting program Gnuplot is freely available, general purpose, easy to use, and available on a variety of platforms. Complex three-dimensional surfaces, including the familiar angular parts of the hydrogen atom orbitals, are easily represented using Gnuplot. Contour plots allow viewing the radial and angular variation of the probability density in an orbital. Examples are given of how Gnuplot is used in an undergraduate physical chemistry class to view familiar atomic orbitals in new ways or to generate views of orbital functions that the student may have not seen before. Gnuplot may also be easily integrated into the environment of a Web page; an example of this is discussed (and is available at http://onsager.bd.psu.edu/~moore/orbitals_gnuplot). The plotting commands are entered with a form and a CGI script is used to run Gnuplot and display the result back to the browser.

  13. Spatial recurrence plots.

    Science.gov (United States)

    Vasconcelos, D B; Lopes, S R; Viana, R L; Kurths, J

    2006-05-01

    We propose an extension of the recurrence plot concept to perform quantitative analyzes of roughness and disorder of spatial patterns at a fixed time. We introduce spatial recurrence plots (SRPs) as a graphical representation of the pointwise correlation matrix, in terms of a two-dimensional spatial return plot. This technique is applied to the study of complex patterns generated by coupled map lattices, which are characterized by measures of complexity based on SRPs. We show that the complexity measures we propose for SRPs provide a systematic way of investigating the distribution of spatially coherent structures, such as synchronization domains, in lattice profiles. This approach has potential for many more applications, e.g., in surface roughness analyzes.

  14. NPLOT - NASTRAN PLOT

    Science.gov (United States)

    Mcentire, K.

    1994-01-01

    NPLOT is an interactive computer graphics program for plotting undeformed and deformed NASTRAN finite element models (FEMs). Although there are many commercial codes already available for plotting FEMs, these have limited use due to their cost, speed, and lack of features to view BAR elements. NPLOT was specifically developed to overcome these limitations. On a vector type graphics device the two best ways to show depth are by hidden line plotting or haloed line plotting. A hidden line algorithm generates views of models with all hidden lines removed, and a haloed line algorithm displays views with aft lines broken in order to show depth while keeping the entire model visible. A haloed line algorithm is especially useful for plotting models composed of many line elements and few surface elements. The most important feature of NPLOT is its ability to create both hidden line and haloed line views accurately and much more quickly than with any other existing hidden or haloed line algorithms. NPLOT is also capable of plotting a normal wire frame view to display all lines of a model. NPLOT is able to aid in viewing all elements, but it has special features not generally available for plotting BAR elements. These features include plotting of TRUE LENGTH and NORMALIZED offset vectors and orientation vectors. Standard display operations such as rotation and perspective are possible, but different view planes such as X-Y, Y-Z, and X-Z may also be selected. Another display option is the Z-axis cut which allows a portion of the fore part of the model to be cut away to reveal details of the inside of the model. A zoom function is available to terminals with a locator (graphics cursor, joystick, etc.). The user interface of NPLOT is designed to make the program quick and easy to use. A combination of menus and commands with help menus for detailed information about each command allows experienced users greater speed and efficiency. Once a plot is on the screen the interface

  15. Homogeneous M2 duals

    CERN Document Server

    Figueroa-O'Farrill, José

    2015-01-01

    Motivated by the search for new gravity duals to M2 branes with $N>4$ supersymmetry --- equivalently, M-theory backgrounds with Killing superalgebra $\\mathfrak{osp}(N|4)$ for $N>4$ --- we classify (except for a small gap) homogeneous M-theory backgrounds with symmetry Lie algebra $\\mathfrak{so}(n) \\oplus \\mathfrak{so}(3,2)$ for $n=5,6,7$. We find that there are no new backgrounds with $n=6,7$ but we do find a number of new (to us) backgrounds with $n=5$. All backgrounds are metrically products of the form $\\operatorname{AdS}_4 \\times P^7$, with $P$ riemannian and homogeneous under the action of $\\operatorname{SO}(5)$, or $S^4 \\times Q^7$ with $Q$ lorentzian and homogeneous under the action of $\\operatorname{SO}(3,2)$. At least one of the new backgrounds is supersymmetric (albeit with only $N=2$) and we show that it can be constructed from a supersymmetric Freund--Rubin background via a Wick rotation. Two of the new backgrounds have only been approximated numerically.

  16. Multi-response optimization of Artemia hatching process using split-split-plot design based response surface methodology

    Science.gov (United States)

    Arun, V. V.; Saharan, Neelam; Ramasubramanian, V.; Babitha Rani, A. M.; Salin, K. R.; Sontakke, Ravindra; Haridas, Harsha; Pazhayamadom, Deepak George

    2017-01-01

    A novel method, BBD-SSPD is proposed by the combination of Box-Behnken Design (BBD) and Split-Split Plot Design (SSPD) which would ensure minimum number of experimental runs, leading to economical utilization in multi- factorial experiments. The brine shrimp Artemia was tested to study the combined effects of photoperiod, temperature and salinity, each with three levels, on the hatching percentage and hatching time of their cysts. The BBD was employed to select 13 treatment combinations out of the 27 possible combinations that were grouped in an SSPD arrangement. Multiple responses were optimized simultaneously using Derringer’s desirability function. Photoperiod and temperature as well as temperature-salinity interaction were found to significantly affect the hatching percentage of Artemia, while the hatching time was significantly influenced by photoperiod and temperature, and their interaction. The optimum conditions were 23 h photoperiod, 29 °C temperature and 28 ppt salinity resulting in 96.8% hatching in 18.94 h. In order to verify the results obtained from BBD-SSPD experiment, the experiment was repeated preserving the same set up. Results of verification experiment were found to be similar to experiment originally conducted. It is expected that this method would be suitable to optimize the hatching process of animal eggs.

  17. Multi-response optimization of Artemia hatching process using split-split-plot design based response surface methodology

    Science.gov (United States)

    Arun, V. V.; Saharan, Neelam; Ramasubramanian, V.; Babitha Rani, A. M.; Salin, K. R.; Sontakke, Ravindra; Haridas, Harsha; Pazhayamadom, Deepak George

    2017-01-01

    A novel method, BBD-SSPD is proposed by the combination of Box-Behnken Design (BBD) and Split-Split Plot Design (SSPD) which would ensure minimum number of experimental runs, leading to economical utilization in multi- factorial experiments. The brine shrimp Artemia was tested to study the combined effects of photoperiod, temperature and salinity, each with three levels, on the hatching percentage and hatching time of their cysts. The BBD was employed to select 13 treatment combinations out of the 27 possible combinations that were grouped in an SSPD arrangement. Multiple responses were optimized simultaneously using Derringer’s desirability function. Photoperiod and temperature as well as temperature-salinity interaction were found to significantly affect the hatching percentage of Artemia, while the hatching time was significantly influenced by photoperiod and temperature, and their interaction. The optimum conditions were 23 h photoperiod, 29 °C temperature and 28 ppt salinity resulting in 96.8% hatching in 18.94 h. In order to verify the results obtained from BBD-SSPD experiment, the experiment was repeated preserving the same set up. Results of verification experiment were found to be similar to experiment originally conducted. It is expected that this method would be suitable to optimize the hatching process of animal eggs. PMID:28091611

  18. Simulation of Runoff Hydrograph on Soil Surfaces with Different Microtopography Using a Travel Time Method at the Plot Scale.

    Science.gov (United States)

    Zhao, Longshan; Wu, Faqi

    2015-01-01

    In this study, a simple travel time-based runoff model was proposed to simulate a runoff hydrograph on soil surfaces with different microtopographies. Three main parameters, i.e., rainfall intensity (I), mean flow velocity (vm) and ponding time of depression (tp), were inputted into this model. The soil surface was divided into numerous grid cells, and the flow length of each grid cell (li) was then calculated from a digital elevation model (DEM). The flow velocity in each grid cell (vi) was derived from the upstream flow accumulation area using vm. The total flow travel time through each grid cell to the surface outlet was the sum of the sum of flow travel times along the flow path (i.e., the sum of li/vi) and tp. The runoff rate at the slope outlet for each respective travel time was estimated by finding the sum of the rain rate from all contributing cells for all time intervals. The results show positive agreement between the measured and predicted runoff hydrographs.

  19. Comparison of Surface Water Quality and Yields from Organically and Conventionally Produced Sweet Corn Plots with Conservation and Conventional Tillage.

    Science.gov (United States)

    Edgell, Joshua; Osmond, D L; Line, D E; Hoyt, G D; Grossman, J M; Larsen, E M

    2015-11-01

    Organic agricultural systems are often assumed to be more sustainable than conventional farming, yet there has been little work comparing surface water quality from organic and conventional production, especially under the same cropping sequence. Our objective was to compare nutrient and sediment losses, as well as sweet corn ( L. var. ) yield, from organic and conventional production with conventional and conservation tillage. The experiment was located in the Appalachian Mountains of North Carolina. Four treatments, replicated four times, had been in place for over 18 yr and consisted of conventional tillage (chisel plow and disk) with conventional production (CT/Conven), conservation no-till with conventional production (NT/Conven), conventional tillage with organic production (CT/Org), and conservation no-till with organic production (NT/Org). Water quality (surface flow volume; nitrogen, phosphorus, and sediment concentrations) and sweet corn yield data were collected in 2011 and 2012. Sediment and sediment-attached nutrient losses were influenced by tillage and cropping system in 2011, due to higher rainfall, and tillage in 2012. Soluble nutrients were affected by the nutrient source and rate, which are a function of the cropping system. Sweet corn marketable yields were greater in conventional systems due to high weed competition and reduced total nitrogen availability in organic treatments. When comparing treatment efficiency (yield kg ha /nutrient loss kg ha ), the NT/Conven treatment had the greatest sweet corn yield per unit of nutrient and sediment loss. Other treatment ratios were similar to each other; thus, it appears the most sustainably productive treatment was NT/Conven.

  20. Determination of the Runoff and Suspended Sediment from Two Different Slope Length Using Field Plots

    Directory of Open Access Journals (Sweden)

    Hüseyin Şensoy

    2013-11-01

    Full Text Available In this study, the effect of slope length on runoff and suspended sediment yield has been investigated by using plots on uniform slopes under natural rainfall conditions. From September 2007 to September 2009, during two year-period, measurements were done in Dallıca village experimental area in Bartın province. In this study, six field plots with a width of 1.87 m were used. Three of them were 5.5 m long (short plots and remaining three were 11.05 m long (long plots. Plots were located on bare soil surface that has no conservative vegetation. During the period of experimentation, a total of 158 rainy days were registered and average annual rainfall amount was 1194.8 mm. Average annual runoff per square meter was 270.81 mm, and 311.27 mm in long and short plots, respectively. Average annual suspended sediment was 809.68 g m-2, and 766.53 g m-2 from long and short plots, respectively. While statistically significant differences were found in runoff amount from plots with different lengths, there were no statistically significant differences in terms of the amount of eroded sediment.

  1. TRAIL protein localization in human primary T cells by 3D microscopy using 3D interactive surface plot: a new method to visualize plasma membrane.

    Science.gov (United States)

    Gras, Christophe; Smith, Nikaïa; Sengmanivong, Lucie; Gandini, Mariana; Kubelka, Claire Fernandes; Herbeuval, Jean-Philippe

    2013-01-31

    The apoptotic ligand TNF-related apoptosis ligand (TRAIL) is expressed on the membrane of immune cells during HIV infection. The intracellular stockade of TRAIL in human primary CD4(+) T cells is not known. Here we investigated whether primary CD4(+) T cells expressed TRAIL in their intracellular compartment and whether TRAIL is relocalized on the plasma membrane under HIV activation. We found that TRAIL protein was stocked in intracellular compartment in non activated CD4(+) T cells and that the total level of TRAIL protein was not increased under HIV-1 stimulation. However, TRAIL was massively relocalized on plasma membrane when cells were cultured with HIV. Using three dimensional (3D) microscopy we localized TRAIL protein in human T cells and developed a new method to visualize plasma membrane without the need of a membrane marker. This method used the 3D interactive surface plot and bright light acquired images.

  2. Soil hydraulic parameters and surface soil moisture of a tilled bare soil plot inversely derived from l-band brightness temperatures

    KAUST Repository

    Dimitrov, Marin

    2014-01-01

    We coupled a radiative transfer model and a soil hydrologic model (HYDRUS 1D) with an optimization routine to derive soil hydraulic parameters, surface roughness, and soil moisture of a tilled bare soil plot using measured brightness temperatures at 1.4 GHz (L-band), rainfall, and potential soil evaporation. The robustness of the approach was evaluated using five 28-d data sets representing different meteorological conditions. We considered two soil hydraulic property models: the unimodal Mualem-van Genuchten and the bimodal model of Durner. Microwave radiative transfer was modeled by three different approaches: the Fresnel equation with depth-averaged dielectric permittivity of either 2-or 5-cm-thick surface layers and a coherent radiative transfer model (CRTM) that accounts for vertical gradients in dielectric permittivity. Brightness temperatures simulated by the CRTM and the 2-cm-layer Fresnel model fitted well to the measured ones. L-band brightness temperatures are therefore related to the dielectric permittivity and soil moisture in a 2-cm-thick surface layer. The surface roughness parameter that was derived from brightness temperatures using inverse modeling was similar to direct estimates from laser profiler measurements. The laboratory-derived water retention curve was bimodal and could be retrieved consistently for the different periods from brightness temperatures using inverse modeling. A unimodal soil hydraulic property function underestimated the hydraulic conductivity near saturation. Surface soil moisture contents simulated using retrieved soil hydraulic parameters were compared with in situ measurements. Depth-specific calibration relations were essential to derive soil moisture from near-surface installed sensors. © Soil Science Society of America 5585 Guilford Rd., Madison, WI 53711 USA.

  3. Hofbauer cells of M2a, M2b and M2c polarization may regulate feto-placental angiogenesis.

    Science.gov (United States)

    Loegl, J; Hiden, U; Nussbaumer, E; Schliefsteiner, C; Cvitic, S; Lang, I; Wadsack, C; Huppertz, B; Desoye, G

    2016-11-01

    The human placenta comprises a special type of tissue macrophages, the Hofbauer cells (HBC), which exhibit M2 macrophage phenotype. Several subtypes of M2-polarized macrophages (M2a, M2b and M2c) exist in almost all tissues. Macrophage polarization depends on the way of macrophage activation and leads to the expression of specific cell surface markers and the acquisition of specific functions, including tissue remodeling and the promotion of angiogenesis. The placenta is a highly vascularized and rapidly growing organ, suggesting a role of HBC in feto-placental angiogenesis. We here aimed to characterize the specific polarization and phenotype of HBC and investigated the role of HBC in feto-placental angiogenesis. Therefore, HBC were isolated from third trimester placentas and their phenotype was determined by the presence of cell surface markers (FACS analysis) and secretion of cytokines (ELISA). HBC conditioned medium (CM) was analyzed for pro-angiogenic factors, and the effect of HBC CM on angiogenesis, proliferation and chemoattraction of isolated primary feto-placental endothelial cells (fpEC) was determined in vitro Our results revealed that isolated HBC possess an M2 polarization, with M2a, M2b and M2c characteristics. HBC secreted the pro-angiogenic molecules VEGF and FGF2. Furthermore, HBC CM stimulated the in vitro angiogenesis of fpEC. However, compared with control medium, chemoattraction of fpEC toward HBC CM was reduced. Proliferation of fpEC was not affected by HBC CM. These findings demonstrate a paracrine regulation of feto-placental angiogenesis by HBC in vitro Based on our collective results, we propose that the changes in HBC number or phenotype may affect feto-placental angiogenesis. © 2016 Society for Reproduction and Fertility.

  4. Density Distribution Sunflower Plots

    OpenAIRE

    Dupont, William D; W. Dale Plummer Jr.

    2003-01-01

    Density distribution sunflower plots are used to display high-density bivariate data. They are useful for data where a conventional scatter plot is difficult to read due to overstriking of the plot symbol. The x-y plane is subdivided into a lattice of regular hexagonal bins of width w specified by the user. The user also specifies the values of l, d, and k that affect the plot as follows. Individual observations are plotted when there are less than l observations per bin as in a conventio...

  5. The plot size effect on soil erosion on rainfed agriculture land under different land uses in eastern Spain

    Science.gov (United States)

    Cerdà, A.; Bodí, M. B.; Burguet, M.; Segura, M.; Jovani, C.

    2009-04-01

    Soil erosion at slope scale is dependent on the size of the plot. This is because soil erosion is a scale-dependent process due to the spatial variability in infiltration, the potential for sediment to be captured by vegetation and other roughness components, and the changes in erosion rates and processes with increasing amounts of runoff. The effects of plot size may also vary with land use, as plot size may be less important in areas with a more homogeneous plant cover or bares soils; meanwhile the soil transmission losses will higher on vegetation covered soils and on patchy distributed plants. A series of study plots were established in 2003 at the El Teularet experimental Station in the Sierra de Enguera in eastern Spain. The overall goal is to assess runoff and erosion rates from different land uses at different spatial scales. Thirteen sets of plots have been established, and each set consists of five adjacent plots that vary in size from 1 m2 (1 x 1 m), 2 m2 (1 x 2 m), 4 m2 (1 x 4 m), 16 m2 (2 x 8 m) and 48 m2 (3 m wide x 16 m length). Each set of plots has a different land use, and the land uses being tested in the first year of this study are fallow, ploughed but unplanted, untilled oats and beans, tilled oats and beans, straw mulch, mulched with chipped olive branches, a geotextile developed to control erosion on agricultural fields, scrub oaks (Quercus coccifera), gorse (Ulex parviflorus), and three herbicide treatments—a systemic herbicide, a contact herbicide, and a persistent herbicide. From those plots, three plots were selected to analyse the effect of the size of the plot on the soil erosion assessment. Herbicide (bare), Catch crops (oat) and scrubland were selected to analyze the soil losses during 2004 and 2005. The results shows that sediment delivery is highly dependent on the land use and land management as the scrubland contributed with null sediment yield, meanwhile the herbicide reached the largest soil loss. The soil erosion was higher

  6. Quantifying Spatial Heterogeneity and Co-variance of Surface Hydrologic Parameters at the Plot Scale in a Semi-arid Landscape

    Science.gov (United States)

    Truschel, A.; Bhark, E. W.; Small, E. E.

    2005-12-01

    In arid to semi-arid ecosystems, the partitioning of precipitation into infiltration, runoff, and interception loss is strongly influenced by the spatial arrangement of vegetation and related (near-)surface hydraulic properties. This partitioning is critical to a variety of hydrological and ecological processes and the interactions between them. On semi-arid hillslopes, we study the spatial patterns of infiltration and runoff, including vegetation mosaic geometry, microtopography, and soil hydraulic properties, from the centimeter to tens-of-meters scale. Approximately 8,000 measurements were collected in creostebush shrubland and black grama grassland hillslopes in the Sevilleta National Wildlife Refuge, central New Mexico. Measurements were collected over plot-scale (100 sq. m.) domains, the surface area of which was defined prior as a representative elementary area (REA) with respect to mosaic geometry, in sampling schemes designed for semivariogram estimation. All measurements were colocated. Auto- and cross- relationships in the form of experimental semivariograms are first characterized between properties out to the maximum measurement scale. These relationships are used to define spatial scales of directional heterogeneity within and between variables. Next, geostatistical models are fit to the experimental data, at appropriately smaller scales, for model parameter estimation. Model parameters are used 1) to identify surface properties that control features of the semivariogram, 2) for the comparison of spatial features between the data sets, and 3) for improved estimation of the measured properties for use in related flow simulation. Results show marked attributes of the semivariogram that can be directly related to spatial patterns of surface properties. Similarly, the strong spatial correlation between properties appears as distinct features on the cross-semivariogram. Corresponding (cross-)semivariogram model parameters indicate that significant

  7. GlobPlot

    DEFF Research Database (Denmark)

    Linding, Rune; Russell, Robert B; Neduva, Victor

    2003-01-01

    are important for protein function. We present here a new tool for discovery of such unstructured, or disordered regions within proteins. GlobPlot (http://globplot.embl.de) is a web service that allows the user to plot the tendency within the query protein for order/globularity and disorder. We show examples...... with known proteins where it successfully identifies inter-domain segments containing linear motifs, and also apparently ordered regions that do not contain any recognised domain. GlobPlot may be useful in domain hunting efforts. The plots indicate that instances of known domains may often contain additional...... N- or C-terminal segments that appear ordered. Thus GlobPlot may be of use in the design of constructs corresponding to globular proteins, as needed for many biochemical studies, particularly structural biology. GlobPlot has a pipeline interface--GlobPipe--for the advanced user to do whole proteome...

  8. Difference and ratio plots

    DEFF Research Database (Denmark)

    Svendsen, Anders Jørgen; Holmskov, U; Bro, Peter

    1995-01-01

    hitherto unnoted differences between controls and patients with either rheumatoid arthritis or systemic lupus erythematosus. For this we use simple, but unconventional, graphic representations of the data, based on difference plots and ratio plots. Differences between patients with Burkitt's lymphoma...... and systemic lupus erythematosus from another previously published study (Macanovic, M. and Lachmann, P.J. (1979) Clin. Exp. Immunol. 38, 274) are also represented using ratio plots. Our observations indicate that analysis by regression analysis may often be misleading....

  9. Fuzzy recurrence plots

    Science.gov (United States)

    Pham, T. D.

    2016-12-01

    Recurrence plots display binary texture of time series from dynamical systems with single dots and line structures. Using fuzzy recurrence plots, recurrences of the phase-space states can be visualized as grayscale texture, which is more informative for pattern analysis. The proposed method replaces the crucial similarity threshold required by symmetrical recurrence plots with the number of cluster centers, where the estimate of the latter parameter is less critical than the estimate of the former.

  10. Análise da topografia da superfície usinada por descargas elétricas do aço-rápido ABNT M2 = Analysis of surface topography in electrical discharge machining of ABNT M2 high speed steel

    Directory of Open Access Journals (Sweden)

    Jean Robert Pereira Rodrigues

    2011-01-01

    Full Text Available A usinagem por descargas elétricas é um processo excepcional para usinagem de formas complexas em materiais condutores elétricos, principalmente para aqueles de alta dureza, difíceis de serem usinados por processos tradicionais. Em cada descarga, uma cratera é formada no material e uma pequena cratera é formada no eletrodo. De todo material fundido produzido em cada descarga, só 15%, ou menos, são removidos através do fluido dielétrico. O restante do material fundido solidifica-se formando uma superfície rugosa. As características da superfície obtida, sobreposição de crateras, glóbulos de impurezas, “chaminés”, bolhas (formadas quando os gases presos são liberados através do material resolidificado, são reveladas através de uma análise por microscopia eletrônica de varredura. O trabalho proposto tem por objetivo estudar o efeito de vários fluidos dielétricos, sobre topografia da superfície e taxa de remoção de material (TRM, no aço rápido ABNT M2, durante a usinagem por descargas elétricas.The electrical discharge machining is an exceptional procedure for machining complex shapes into electric conductor materials, mainly for those of high hardness, difficult of machining by traditional processes. At each discharge, a crater is formed in the material and a small crater is formed in the electrode. From every molten material produced in each discharge, only 15%, or less is removed through the dielectric liquid. The remaining of molten material solidifies forming a wrinkled surface. The characteristics of the obtained surface, as overlap of craters, globules of sullage, “chimneys", bubbles (formed when trapped gases are released through the resolidified material, are revealed through an analysis by scanning electron microscopy. The proposed study aimed to examine the effect of several dielectric fluids, on the surface topography and material removal rate, in workpiece of high speed steel (ABNT M2, during the

  11. A study on the impact of hydroxypropyl methylcellulose on the viscosity of PEG melt suspensions using surface plots and principal component analysis.

    Science.gov (United States)

    Oh, Ching Mien; Heng, Paul Wan Sia; Chan, Lai Wah

    2015-04-01

    An understanding of the rheological behaviour of polymer melt suspensions is crucial in pharmaceutical manufacturing, especially when processed by spray congealing or melt extruding. However, a detailed comparison of the viscosities at each and every temperature and concentration between the various grades of adjuvants in the formulation will be tedious and time-consuming. Therefore, the statistical method, principal component analysis (PCA), was explored in this study. The composite formulations comprising polyethylene glycol (PEG) 3350 and hydroxypropyl methylcellulose (HPMC) of ten different grades (K100 LV, K4M, K15M, K100M, E15 LV, E50 LV, E4M, F50 LV, F4M and Methocel VLV) at various concentrations were prepared and their viscosities at different temperatures determined. Surface plots showed that concentration of HPMC had a greater effect on the viscosity compared to temperature. Particle size and size distribution of HPMC played an important role in the viscosity of melt suspensions. Smaller particles led to a greater viscosity than larger particles. PCA was used to evaluate formulations of different viscosities. The complex viscosity profiles of the various formulations containing HPMC were successfully classified into three clusters of low, moderate and high viscosity. Formulations within each group showed similar viscosities despite differences in grade or concentration of HPMC. Formulations in the low viscosity cluster were found to be sprayable. PCA was able to differentiate the complex viscosity profiles of different formulations containing HPMC in an efficient and time-saving manner and provided an excellent visualisation of the data.

  12. Electron-microscopic study of the structure of the surface layer in high-nitrogen 05Kh22AG15N8M2F steel after face turning

    Science.gov (United States)

    Blinov, E. V.

    2016-01-01

    The structure of the surface layer in high-nitrogen 05Kh22AG15N8M2F steel workpieces subjected to face turning is studied by electron microscopy. It is found that improved machinability by VK8 alloy cutting tools is achieved at a cutting depth of 0.25 mm and that the cutting-tool life decreases sharply when the cutting depth increases to 1 mm. A nanocrystalline structure with nanocrystal sizes from several to several tens of nanometers forms in the surface layer upon face turning in the as-cast, hot-rolled, and thermally deformed states. The structure of the surface layer is characterized by a high dislocation density and large austenite fragments with broad subgrains and deformation twins.

  13. Distributed plot-making

    DEFF Research Database (Denmark)

    Jensen, Lotte Groth; Bossen, Claus

    2016-01-01

    different socio-technical systems (paper-based and electronic patient records). Drawing on the theory of distributed cognition and narrative theory, primarily inspired by the work done within health care by Cheryl Mattingly, we propose that the creation of overview may be conceptualised as ‘distributed plot......-making’. Distributed cognition focuses on the role of artefacts, humans and their interaction in information processing, while narrative theory focuses on how humans create narratives through the plot construction. Hence, the concept of distributed plot-making highlights the distribution of information processing...... between different social actors and artefacts, as well as the filtering, sorting and ordering of such information into a narrative that is made coherent by a plot. The analysis shows that the characteristics of paper-based and electronic patient records support or obstruct the creation of overview in both...

  14. Multiple plots in R

    DEFF Research Database (Denmark)

    Edwards, Stefan McKinnon

    2012-01-01

    In this chapter I will investigate how to combine multiple plots into a single. The scenario is a dataset of a series of measurements, on three samples in three situations. There are many ways we can display this, e.g. 3d graphs or faceting. 3d graphs are not good for displaying static data so we...... will not go there. Faceting is strictly speaking for plotting all variable / classes against each other....

  15. Multiple plots in R

    DEFF Research Database (Denmark)

    Edwards, Stefan McKinnon

    2012-01-01

    In this chapter I will investigate how to combine multiple plots into a single. The scenario is a dataset of a series of measurements, on three samples in three situations. There are many ways we can display this, e.g. 3d graphs or faceting. 3d graphs are not good for displaying static data so we...... will not go there. Faceting is strictly speaking for plotting all variable / classes against each other....

  16. Density Distribution Sunflower Plots

    Directory of Open Access Journals (Sweden)

    William D. Dupont

    2003-01-01

    Full Text Available Density distribution sunflower plots are used to display high-density bivariate data. They are useful for data where a conventional scatter plot is difficult to read due to overstriking of the plot symbol. The x-y plane is subdivided into a lattice of regular hexagonal bins of width w specified by the user. The user also specifies the values of l, d, and k that affect the plot as follows. Individual observations are plotted when there are less than l observations per bin as in a conventional scatter plot. Each bin with from l to d observations contains a light sunflower. Other bins contain a dark sunflower. In a light sunflower each petal represents one observation. In a dark sunflower, each petal represents k observations. (A dark sunflower with p petals represents between /2-pk k and /2+pk k observations. The user can control the sizes and colors of the sunflowers. By selecting appropriate colors and sizes for the light and dark sunflowers, plots can be obtained that give both the overall sense of the data density distribution as well as the number of data points in any given region. The use of this graphic is illustrated with data from the Framingham Heart Study. A documented Stata program, called sunflower, is available to draw these graphs. It can be downloaded from the Statistical Software Components archive at http://ideas.repec.org/c/boc/bocode/s430201.html . (Journal of Statistical Software 2003; 8 (3: 1-5. Posted at http://www.jstatsoft.org/index.php?vol=8 .

  17. Plot til lyst

    DEFF Research Database (Denmark)

    Sandvik, Kjetil

    Den velfungerende krimi faciliterer denne dobbelte plotlæsning ved at muliggøre en særlig form for legende og udforskende interaktion mellem læser og plot: Ved at lægge spor ud og holde tolkningsmuligheder og løsningsmuligheder åbne får vi mulighed for at påtage os og udføre opklaringsarbejdet side......, der inviterer os med ind i selve handlingens rum og forløb og giver os forskellige handlingsmuligheder i forhold til disse. I bogen omtales denne særlige form for plot for forlystelsesplot med henvisning til forlystelsesparken og den særlige form for interaktiv fortælleform, som vi finder der: en...

  18. corner: Corner plots

    Science.gov (United States)

    Foreman-Mackey, Daniel

    2017-02-01

    corner uses matplotlib to visualize multidimensional samples using a scatterplot matrix. In these visualizations, each one- and two-dimensional projection of the sample is plotted to reveal covariances. corner was originally conceived to display the results of Markov Chain Monte Carlo simulations and the defaults are chosen with this application in mind but it can be used for displaying many qualitatively different samples. An earlier version of corner was known as triangle.py.

  19. The Half-Half Plot

    NARCIS (Netherlands)

    Einmahl, J.H.J.; Gantner, M.

    2009-01-01

    The Half-Half (HH) plot is a new graphical method to investigate qualitatively the shape of a regression curve. The empirical HH-plot counts observations in the lower and upper quarter of a strip that moves horizontally over the scatter plot. The plot displays jumps clearly and reveals further featu

  20. The Half-Half Plot

    NARCIS (Netherlands)

    Einmahl, J.H.J.; Gantner, M.

    2009-01-01

    The Half-Half (HH) plot is a new graphical method to investigate qualitatively the shape of a regression curve. The empirical HH-plot counts observations in the lower and upper quarter of a strip that moves horizontally over the scatter plot. The plot displays jumps clearly and reveals further

  1. The Half-Half Plot

    NARCIS (Netherlands)

    Einmahl, J.H.J.; Gantner, M.

    2009-01-01

    The Half-Half (HH) plot is a new graphical method to investigate qualitatively the shape of a regression curve. The empirical HH-plot counts observations in the lower and upper quarter of a strip that moves horizontally over the scatter plot. The plot displays jumps clearly and reveals further featu

  2. matplotlib plotting cookbook

    CERN Document Server

    Devert, Alexandre

    2014-01-01

    This book follows a cookbook style approach that puts orthogonal and non-redundant recipes in your hands. Rather than rehashing the user manual, the explanations expose the underlying logic behind Matplotlib. If you are an engineer or scientist who wants to create great visualizations with Python, rather than yet another specialized language, this is the book for you. While there are several very competent plotting packages, Matplotlib is ""just"" a Python module. Thus, if you know some Python already, you will feel at home from the first steps on. In case you are an application writer, you wo

  3. Plotting Gothic: A Paradox

    Directory of Open Access Journals (Sweden)

    Stephen Murray

    2014-06-01

    Full Text Available The paradox of the title is that while most historians of medieval architecture agree that a combination of geometric and arithmetic methods was generally used to lay out a medieval church, there has been little consensus on the specifics of the process in relation to the design of any particular edifice. I begin by identifying four premises which underlie the debate. I then ask whether the new technologies — laser scanning and computer assisted design/drafting applications — can help. A case study uses newly generated point cloud data from a laser scan of the choir of Beauvais Cathedral. Finally, the notion of ‘plotting’ introduces essential sociological, anthropological and rhetorical dimensions. In the spirit of Roland Barthes ('Le plaisir du texte' and Peter Brooks ('Reading for the Plot', we can understand the urgency with which the architectural historian may seek to unscramble the hidden codes of the building as compulsive ‘reading for the plot’.

  4. Aristotle's theory of tragedy plot and comparison with modern plot

    Institute of Scientific and Technical Information of China (English)

    宋莹

    2008-01-01

    This paper is to study Aristotle's theory of tragedy and his tragedy plot from the Poetics. He says,'tragedy is an imitation of an action that is serious,complete,and of adequate magnitude-in language embellished in different ways in different parts-in the form of action,not of narration-through pity and fear effecting the purgation of these emotions. The elements of tragedy are plot,character,thought,diction,melody and spectacle in their order of importance.' However there exist some differences and similarities between his plot in Poetics and modern plot.

  5. What is $\\Delta m^2_{ee}$ ?

    CERN Document Server

    Parke, Stephen

    2016-01-01

    The current short baseline reactor experiments, Daya Bay and RENO (Double Chooz) have measured (or are capable of measuring) an effective $\\Delta m^2$ associated with the atmospheric oscillation scale of 0.5 km/MeV in electron anti-neutrino disappearance. In this paper, I compare and contrast the different definitions of such an effective $\\Delta m^2$ and argue that the simple, L/E independent, definition given by $\\Delta m^2_{ee} \\equiv \\cos^2 \\theta_{12} \\Delta m^2_{31}+ \\sin^2 \\theta_{12} \\Delta m^2_{32}$, i.e. "the $\

  6. GnuForPlot Graphics

    Energy Technology Data Exchange (ETDEWEB)

    2015-11-04

    Gnuforplot Graphics is a Fortran90 program designed to generate two and three dimensional plots of data on a personal computer. The program uses calls to the open source code Gnuplot to generate the plots. Two Fortran90 programs have been written to use the Gnuplot graphics capabilities. The first program, named Plotsetup.f90 reads data from output files created by either the Stadium or LeachXS/Orchestra modeling codes and saves the data in arrays for plotting. This program then calls Gnuforplot which takes the data array along with user specified parameters to set plot specifications and issues Gnuplot commands that generate the screen plots. The user can view the plots and optionally save copies in jpeg format.

  7. Box-and-Whisker Plots.

    Science.gov (United States)

    Larsen, Russell D.

    1985-01-01

    Box-and-whisker plots (which give rapid visualization of batches of data) can be effectively used to present diverse collections of data used in traditional first-year chemistry courses. Construction of box-and-whisker plots and their use with bond energy data and data on heats of formation and solution are discussed. (JN)

  8. S2PLOT: Three-dimensional (3D) Plotting Library

    Science.gov (United States)

    Barnes, D. G.; Fluke, C. J.; Bourke, P. D.; Parry, O. T.

    2011-03-01

    We present a new, three-dimensional (3D) plotting library with advanced features, and support for standard and enhanced display devices. The library - S2PLOT - is written in C and can be used by C, C++ and FORTRAN programs on GNU/Linux and Apple/OSX systems. S2PLOT draws objects in a 3D (x,y,z) Cartesian space and the user interactively controls how this space is rendered at run time. With a PGPLOT inspired interface, S2PLOT provides astronomers with elegant techniques for displaying and exploring 3D data sets directly from their program code, and the potential to use stereoscopic and dome display devices. The S2PLOT architecture supports dynamic geometry and can be used to plot time-evolving data sets, such as might be produced by simulation codes. In this paper, we introduce S2PLOT to the astronomical community, describe its potential applications, and present some example uses of the library.

  9. M2M massive wireless access

    DEFF Research Database (Denmark)

    Zanella, Andrea; Zorzi, Michele; Santos, André F.

    2013-01-01

    of the current cellular standards. Here, we provide insights and introduce potential solutions for the cellular radio protocol that will allow the efficient support of Machine-to-Machine (M2M) communications. The paper focuses on the massive aspect of M2M. We will introduce PHY and MAC approaches such as Coded...... and research guidelines for enabling future networks to support efficiently M2M communications....

  10. PLOT3D user's manual

    Science.gov (United States)

    Walatka, Pamela P.; Buning, Pieter G.; Pierce, Larry; Elson, Patricia A.

    1990-01-01

    PLOT3D is a computer graphics program designed to visualize the grids and solutions of computational fluid dynamics. Seventy-four functions are available. Versions are available for many systems. PLOT3D can handle multiple grids with a million or more grid points, and can produce varieties of model renderings, such as wireframe or flat shaded. Output from PLOT3D can be used in animation programs. The first part of this manual is a tutorial that takes the reader, keystroke by keystroke, through a PLOT3D session. The second part of the manual contains reference chapters, including the helpfile, data file formats, advice on changing PLOT3D, and sample command files.

  11. Trellis plots as visual aids for analyzing split plot experiments

    DEFF Research Database (Denmark)

    Kulahci, Murat; Menon, Anil

    2017-01-01

    The analysis of split plot experiments can be challenging due to a complicated error structure resulting from restrictions on complete randomization. Similarly, standard visualization methods do not provide the insight practitioners desire to understand the data, think of explanations, generate...... hypotheses, build models, or decide on next steps. This article demonstrates the effective use of trellis plots in the preliminary data analysis for split plot experiments to address this problem. Trellis displays help to visualize multivariate data by allowing for conditioning in a general way. They can...

  12. Assigning error to an M2 measurement

    Science.gov (United States)

    Ross, T. Sean

    2006-02-01

    The ISO 11146:1999 standard has been published for 6 years and set forth the proper way to measure the M2 parameter. In spite of the strong experimental guidance given by this standard and the many commercial devices based upon ISO 11146, it is still the custom to quote M2 measurements without any reference to significant figures or error estimation. To the author's knowledge, no commercial M2 measurement device includes error estimation. There exists, perhaps, a false belief that M2 numbers are high precision and of insignificant error. This paradigm causes program managers and purchasers to over-specify a beam quality parameter and researchers not to question the accuracy and precision of their M2 measurements. This paper will examine the experimental sources of error in an M2 measurement including discretization error, CCD noise, discrete filter sets, noise equivalent aperture estimation, laser fluctuation and curve fitting error. These sources of error will be explained in their experimental context and convenient formula given to properly estimate error in a given M2 measurement. This work is the result of the author's inability to find error estimation and disclosure of methods in commercial beam quality measurement devices and building an ISO 11146 compliant, computer- automated M2 measurement device and the resulting lessons learned and concepts developed.

  13. Phosphorus export by runoff from agricultural field plots with different crop cover in Lake Taihu watershed

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Runoff and soil losses from agricultural fields are investigated as major nonpoint sources of phosphorus (P) entering lakes of Eastern China. There is relatively little information on P transport from ricefield and cropland of Lake Taihu watershed in Eastern China. Soil and P in surface runoff from a series of plots in the watershed were evaluated under simulated rainfall conditions. The objectives of this study were to evaluate theeffects of crop cover, slope, and fertilizer application on P concentrations in surface runoff and eroded soil. Accumulated sediment yields varied from 7.1 to 300 g/m2 for croplands, depending on management practices. For all experiment plots, weighted average concentrations of total-P (TP), dissolved P (DP) and particulate P (PP) are much higher than 0.02 mg/L, the limiting concentration in lake water. This result showed the potential contamination of lake water from agricultural surface runoff. Accumulated TP losses were 3.8 and 18.8 mg/m2 for ricefield and cropland, respectively. The estimated annual loss of TP was 0.74 kg/(hm2鷄) for cropland. Most of P loss is in PP form, which accounts for more than 90% of TP loss for cropland.

  14. Action Between Plot and Discourse

    DEFF Research Database (Denmark)

    Grünbaum, Thor

    2007-01-01

    , these narrated actions disrupt the theoretical divisions, on the one hand, between the narrated story and the narrating discourse, and on the other hand, between plot-narratology and discourse-narratology. As narrated actions, they seem to belong to the domain of plot-narratology, but insofar as they serve...... an important visualizing function, these narrated actions have a communicative function and, as such, they can be said to belong to the domain of discourse-narratology. In the first part of the article, I argue that a certain type of plot-narratology, due to its retrospective epistemology and abstract...

  15. Action Between Plot and Discourse

    DEFF Research Database (Denmark)

    Grünbaum, Thor

    2007-01-01

    , these narrated actions disrupt the theoretical divisions, on the one hand, between the narrated story and the narrating discourse, and on the other hand, between plot-narratology and discourse-narratology. As narrated actions, they seem to belong to the domain of plot-narratology, but insofar as they serve...... an important visualizing function, these narrated actions have a communicative function and, as such, they can be said to belong to the domain of discourse-narratology. In the first part of the article, I argue that a certain type of plot-narratology, due to its retrospective epistemology and abstract...

  16. Tachyonic Anti-M2 Branes

    CERN Document Server

    Bena, Iosif; Kuperstein, Stanislav; Massai, Stefano

    2014-01-01

    We study the dynamics of anti-M2 branes in a warped Stenzel solution with M2 charges dissolved in fluxes by taking into account their full backreaction on the geometry. The resulting supergravity solution has a singular magnetic four-form flux in the near-brane region. We examine the possible resolution of this singularity via the polarization of anti-M2 branes into M5 branes, and compute the corresponding polarization potential for branes smeared on the finite-size four-sphere at the tip of the Stenzel space. We find that the potential has no minimum. We then use the potential for smeared branes to compute the one corresponding to a stack of localized anti-M2 branes, and use this potential to compute the force between two anti-M2 branes at tip of the Stenzel space. We find that this force, which is zero in the probe approximation, is in fact repulsive. This surprising result points to a tachyonic instability of anti-M2 branes in backgrounds with M2 brane charge dissolved in flux.

  17. Normal probability plots with confidence.

    Science.gov (United States)

    Chantarangsi, Wanpen; Liu, Wei; Bretz, Frank; Kiatsupaibul, Seksan; Hayter, Anthony J; Wan, Fang

    2015-01-01

    Normal probability plots are widely used as a statistical tool for assessing whether an observed simple random sample is drawn from a normally distributed population. The users, however, have to judge subjectively, if no objective rule is provided, whether the plotted points fall close to a straight line. In this paper, we focus on how a normal probability plot can be augmented by intervals for all the points so that, if the population distribution is normal, then all the points should fall into the corresponding intervals simultaneously with probability 1-α. These simultaneous 1-α probability intervals provide therefore an objective mean to judge whether the plotted points fall close to the straight line: the plotted points fall close to the straight line if and only if all the points fall into the corresponding intervals. The powers of several normal probability plot based (graphical) tests and the most popular nongraphical Anderson-Darling and Shapiro-Wilk tests are compared by simulation. Based on this comparison, recommendations are given in Section 3 on which graphical tests should be used in what circumstances. An example is provided to illustrate the methods.

  18. M2M massive wireless access

    DEFF Research Database (Denmark)

    Zanella, Andrea; Zorzi, Michele; Santos, André F.

    2013-01-01

    In order to make the Internet of Things a reality, ubiquitous coverage and low-complexity connectivity are required. Cellular networks are hence the most straightforward and realistic solution to enable a massive deployment of always connected Machines around the globe. Nevertheless, a paradigm...... of the current cellular standards. Here, we provide insights and introduce potential solutions for the cellular radio protocol that will allow the efficient support of Machine-to-Machine (M2M) communications. The paper focuses on the massive aspect of M2M. We will introduce PHY and MAC approaches such as Coded...

  19. A K-sample Homogeneity Test based on the Quantification of the p-p Plot

    NARCIS (Netherlands)

    J. Hinloopen (Jeroen); R. Wagenvoort (Rien); J.G.M. van Marrewijk (Charles)

    2008-01-01

    textabstractWe propose a quantification of the p-p plot that assigns equal weight to all distances between the respective distributions: the surface between the p-p plot and the diagonal. This surface is labelled the Harmonic Weighted Mass (HWM) index. We introduce the diagonal-deviation (d-d) plot

  20. A K-sample Homogeneity Test based on the Quantification of the p-p Plot

    NARCIS (Netherlands)

    Hinloopen, Jeroen; Wagenvoort, Rien; Marrewijk, van Charles

    2008-01-01

    We propose a quantification of the p-p plot that assigns equal weight to all distances between the respective distributions: the surface between the p-p plot and the diagonal. This surface is labelled the Harmonic Weighted Mass (HWM) index. We introduce the diagonal-deviation (d-d) plot that allows

  1. A K-sample Homogeneity Test based on the Quantification of the p-p Plot

    NARCIS (Netherlands)

    J. Hinloopen (Jeroen); R. Wagenvoort (Rien); J.G.M. van Marrewijk (Charles)

    2008-01-01

    textabstractWe propose a quantification of the p-p plot that assigns equal weight to all distances between the respective distributions: the surface between the p-p plot and the diagonal. This surface is labelled the Harmonic Weighted Mass (HWM) index. We introduce the diagonal-deviation (d-d) plot

  2. A K-sample Homogeneity Test based on the Quantification of the p-p Plot

    NARCIS (Netherlands)

    Hinloopen, Jeroen; Wagenvoort, Rien; Marrewijk, van Charles

    2008-01-01

    We propose a quantification of the p-p plot that assigns equal weight to all distances between the respective distributions: the surface between the p-p plot and the diagonal. This surface is labelled the Harmonic Weighted Mass (HWM) index. We introduce the diagonal-deviation (d-d) plot that allows

  3. Anti-influenza M2e antibody

    Science.gov (United States)

    Bradbury, Andrew M.

    2011-12-20

    Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza.

  4. Anti-influenza M2e antibody

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Andrew M.

    2013-04-16

    Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza.

  5. Anti-influenza M2e antibody

    Science.gov (United States)

    Bradbury, Andrew M.

    2013-04-16

    Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza.

  6. Round versus rectangular: Does the plot shape matter?

    Science.gov (United States)

    Iserloh, Thomas; Bäthke, Lars; Ries, Johannes B.

    2016-04-01

    Field rainfall simulators are designed to study soil erosion processes and provide urgently needed data for various geomorphological, hydrological and pedological issues. Due to the different conditions and technologies applied, there are several methodological aspects under review of the scientific community, particularly concerning design, procedures and conditions of measurement for infiltration, runoff and soil erosion. Extensive discussions at the Rainfall Simulator Workshop 2011 in Trier and the Splinter Meeting at EGU 2013 "Rainfall simulation: Big steps forward!" lead to the opinion that the rectangular shape is the more suitable plot shape compared to the round plot. A horizontally edging Gerlach trough is installed for sample collection without forming unnatural necks as is found at round or triangle plots. Since most research groups did and currently do work with round plots at the point scale (<1m²), a precise analysis of the differences between the output of round and square plots are necessary. Our hypotheses are: - Round plot shapes disturb surface runoff, unnatural fluvial dynamics for the given plot size such as pool development especially directly at the plot's outlet occur. - A square plot shape prevent these problems. A first comparison between round and rectangular plots (Iserloh et al., 2015) indicates that the rectangular plot could indeed be the more suitable, but the rather ambiguous results make a more elaborate test setup necessary. The laboratory test setup includes the two plot shapes (round, square), a standardised silty substrate and three inclinations (2°, 6°, 12°). The analysis of the laboratory test provide results on the best performance concerning undisturbed surface runoff and soil/water sampling at the plot's outlet. The analysis of the plot shape concerning its influence on runoff and erosion shows that clear methodological standards are necessary in order to make rainfall simulation experiments comparable. Reference

  7. MatrixPlot: visualizing sequence constraints

    DEFF Research Database (Denmark)

    Gorodkin, Jan; Stærfeldt, Hans Henrik; Lund, Ole

    1999-01-01

    MatrixPlot: visualizing sequence constraints. Sub-title Abstract Summary : MatrixPlot is a program for making high-quality matrix plots, such as mutual information plots of sequence alignments and distance matrices of sequences with known three-dimensional coordinates. The user can add information...... about the sequences (e.g. a sequence logo profile) along the edges of the plot, as well as zoom in on any region in the plot. Availability : MatrixPlot can be obtained on request, and can also be accessed online at http://www. cbs.dtu.dk/services/MatrixPlot. Contact : gorodkin@cbs.dtu.dk...

  8. MatrixPlot: visualizing sequence constraints

    DEFF Research Database (Denmark)

    Gorodkin, Jan; Stærfeldt, Hans Henrik; Lund, Ole

    1999-01-01

    MatrixPlot: visualizing sequence constraints. Sub-title Abstract Summary : MatrixPlot is a program for making high-quality matrix plots, such as mutual information plots of sequence alignments and distance matrices of sequences with known three-dimensional coordinates. The user can add information...... about the sequences (e.g. a sequence logo profile) along the edges of the plot, as well as zoom in on any region in the plot. Availability : MatrixPlot can be obtained on request, and can also be accessed online at http://www. cbs.dtu.dk/services/MatrixPlot. Contact : gorodkin@cbs.dtu.dk...

  9. Superconformal indices and M2-branes

    Energy Technology Data Exchange (ETDEWEB)

    Eager, Richard [Kavli Institute for the Physics and Mathematics of the Universe (WPI),University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Schmude, Johannes [RIKEN Nishina Center, Saitama 351-0198 (Japan)

    2015-12-10

    We derive the superconformal index of the world-volume theory on M2-branes probing the cone over an arbitrary Sasaki-Einstein seven-manifold. The index is expressed in terms of the cohomology groups of the cone. We match our supergravity results with known results from gauge theory. Along the way we derive the spectrum of short Kaluza-Klein multiplets on generic Sasaki-Einstein seven-manifolds.

  10. Superconformal indices and M2-branes

    Science.gov (United States)

    Eager, Richard; Schmude, Johannes

    2015-12-01

    We derive the superconformal index of the world-volume theory on M2-branes probing the cone over an arbitrary Sasaki-Einstein seven-manifold. The index is expressed in terms of the cohomology groups of the cone. We match our supergravity results with known results from gauge theory. Along the way we derive the spectrum of short Kaluza-Klein multiplets on generic Sasaki-Einstein seven-manifolds.

  11. Convergence of Place and Plot

    DEFF Research Database (Denmark)

    Sandvik, Kjetil

    2010-01-01

    efterladt sig en række mærker og spor som kan læses og fortolkes. Blodspor, rester af negle, hår udgør forskellige (DNA)koder som kan dekrypteres og dechifreres på samme måde som krudtslam, skudhuller, fysiske skader er tegn som skal læses og fortolkes. Som sådan rummer stedet et plot (en fortælling) som...

  12. Heterogeneous Molecular Catalysis of Electrochemical Reactions: Volcano Plots and Catalytic Tafel Plots.

    Science.gov (United States)

    Costentin, Cyrille; Savéant, Jean-Michel

    2017-06-14

    We analyze here, in the framework of heterogeneous molecular catalysis, the reasons for the occurrence or nonoccurrence of volcanoes upon plotting the kinetics of the catalytic reaction versus the stabilization free energy of the primary intermediate of the catalytic process. As in the case of homogeneous molecular catalysis or catalysis by surface-active metallic sites, a strong motivation of such studies relates to modern energy challenges, particularly those involving small molecules, such as water, hydrogen, oxygen, proton, and carbon dioxide. This motivation is particularly pertinent for what concerns heterogeneous molecular catalysis, since it is commonly preferred to homogeneous molecular catalysis by the same molecules if only for chemical separation purposes and electrolytic cell architecture. As with the two other catalysis modes, the main drawback of the volcano plot approach is the basic assumption that the kinetic responses depend on a single descriptor, viz., the stabilization free energy of the primary intermediate. More comprehensive approaches, investigating the responses to the maximal number of experimental factors, and conveniently expressed as catalytic Tafel plots, should clearly be preferred. This is more so in the case of heterogeneous molecular catalysis in that additional transport factors in the supporting film may additionally affect the current-potential responses. This is attested by the noteworthy presence of maxima in catalytic Tafel plots as well as their dependence upon the cyclic voltammetric scan rate.

  13. AUTOMATED TECHNIQUE FOR CREATING LITHOLOGIC LOG PLOTS

    Directory of Open Access Journals (Sweden)

    Kristijan Posavec

    2006-12-01

    Full Text Available Paper presents automated technique for creating lithologic log plots. Technique is based on three computer tools: Microsoft (MS Access program, LogPlot program, and Visual Basic (VB macros for MS Excel. MS Access ensures professional storage of lithologic data which can be in that way easier and faster entered, searched, updated, and also used for different purposes, while LogPlot provides tools for creating lithologic log plots. VB macros enable transfer of lithologic data from MS Access to LogPlot. Data stored in MS Access are exported in ASCII files which are later used by LogPlot for creation of lithologic log plots. Presented concept facilitates creation of lithologic log plots, and automated technique enables processing of a large number of data i.e. creation of lareg number lithologic log plots in a short period of time (the paper is published in Croatian.

  14. CFD Extraction Tool for TecPlot From DPLR Solutions

    Science.gov (United States)

    Norman, David

    2013-01-01

    This invention is a TecPlot macro of a computer program in the TecPlot programming language that processes data from DPLR solutions in TecPlot format. DPLR (Data-Parallel Line Relaxation) is a NASA computational fluid dynamics (CFD) code, and TecPlot is a commercial CFD post-processing tool. The Tec- Plot data is in SI units (same as DPLR output). The invention converts the SI units into British units. The macro modifies the TecPlot data with unit conversions, and adds some extra calculations. After unit conversions, the macro cuts a slice, and adds vectors on the current plot for output format. The macro can also process surface solutions. Existing solutions use manual conversion and superposition. The conversion is complicated because it must be applied to a range of inter-related scalars and vectors to describe a 2D or 3D flow field. It processes the CFD solution to create superposition/comparison of scalars and vectors. The existing manual solution is cumbersome, open to errors, slow, and cannot be inserted into an automated process. This invention is quick and easy to use, and can be inserted into an automated data-processing algorithm.

  15. LOSA-M2 aerosol Raman lidar

    Energy Technology Data Exchange (ETDEWEB)

    Balin, Yu S; Bairashin, G S; Kokhanenko, G P; Penner, I E; Samoilova, S V [V.E. Zuev Institute of Atmospheric Optics, Siberian Branch, Russian Academy of Sciences, Tomsk (Russian Federation)

    2011-10-31

    The scanning LOSA-M2 aerosol Raman lidar, which is aimed at probing atmosphere at wavelengths of 532 and 1064 nm, is described. The backscattered light is received simultaneously in two regimes: analogue and photon-counting. Along with the signals of elastic light scattering at the initial wavelengths, a 607-nm Raman signal from molecular nitrogen is also recorded. It is shown that the height range of atmosphere probing can be expanded from the near-Earth layer to stratosphere using two (near- and far-field) receiving telescopes, and analogue and photon-counting lidar signals can be combined into one signal. Examples of natural measurements of aerosol stratification in atmosphere along vertical and horizontal paths during the expeditions to the Gobi Desert (Mongolia) and Lake Baikal areas are presented.

  16. Periodic Arrays of M2-Branes

    CERN Document Server

    Jeon, Imtak; Richmond, Paul

    2012-01-01

    We consider periodic arrays of M2-branes in the ABJM model in the spirit of a circle compactification to D2-branes in type IIA string theory. The result is a curious formulation of three-dimensional maximally supersymmetric Yang-Mills theory in terms of fermions, seven transverse scalars, a non-dynamical gauge field and an additional scalar `dual gluon'. Upon further T-duality on a transverse torus we obtain a non-manifest-Lorentz-invariant description of five-dimensional maximally supersymmetric Yang-Mills. Here the additional scalar field can be thought of as the components of a two-form along the torus. This action can be viewed as an M-theory description of M5-branes on ${\\mathbb T}^3$.

  17. The (178m2)Hf Controversy

    Energy Technology Data Exchange (ETDEWEB)

    Becker, J A; Gemmell, D S; Schiffer, J P; Wilhelmy, J B

    2003-07-24

    Since its discovery in the 1960's the {sup 178m2}Hf isomer has garnered high attention from both the basic and applied communities in nuclear science. It's combination of high spin (16+), long half life (31 yrs), and high excitation energy (2.446 MeV) offer unique possibilities as an energy storage medium. Interest in the isomer was rekindled beginning in 1999 when a series of publications began to appear from a group (referred to here as the ''Texas collaboration'') primarily based at the University of Texas, Dallas [1]. They reported observations that some of the stored energy could be released (''triggered'') when the isomer was exposed to a fluence of photons in the energy range {approx}10 to {approx}60 keV. The implications of this observation are profound. Even though the claimed cross section for the process was {approx}7 orders of magnitude greater than would be predicted from the known systematics of photon absorption by nuclei in this mass range [2], such a highly efficient method for triggering the isomeric deexcitation immediately suggested applications utilizing the explosive or the controlled gradual energy release from a very compact source. The prospect of such applications has focused considerable interest on realizing the promise that is implicit in the reported observations. However, two experiments performed by a group from ANL/LANL/LLNL at the Advanced Photon Source at Argonne (the ''APS collaboration'') reported negative results for the observation of any photon-triggered deexcitation of the {sup 178m2}Hf isomer [3]. This has led to a continued controversy, where both sides have adamantly defended their observations. At this point an outsider has difficulty determining whether there is indeed a triggering effect that should be pursued energetically with substantial resources, or whether the phenomenon consists of overly optimistic interpretation of data.

  18. PLOT3D: An Interactive Graphics Code for Three Dimensional Plots.

    Science.gov (United States)

    1984-09-28

    all program parameters PLOTF Plots the function y-f(x.z) according to the specified programs parameters. PLOTS Manipulates data for scaling and angles...of rotation; Calls PLOTF to plot each line PERIM Draws the plane of projection and perimeter around the plotted data PLTIF Puts data information on...PLT3T ADISP Clears alphanumeric display PLOTS Same as in PLT3T segment PLOTF Plots on pen plotter instead of the graphics terminal PERIM Same as in

  19. Evidence of paired M2 muscarinic receptors

    Energy Technology Data Exchange (ETDEWEB)

    Potter, L.T.; Ballesteros, L.A.; Bichajian, L.H.; Ferrendelli, C.A.; Fisher, A.; Hanchett, H.E.; Zhang, R. (Univ. of Miami School of Medicine, FL (USA))

    1991-02-01

    Binding assays involving various antagonists, including N-(3H) methylscopolamine, (3H)quinuclidinyl benzilate, AFDX-116, pirenzepine, and propylbenzilylcholine mustard, disclosed only a single population of M2 muscarinic receptors in membranes from the rat brainstem (medulla, pons, and colliculi). However, competition curves between N-(3H)methylscopolamine and various agonists, including oxotremorine, cis-dioxolane, and acetylethylcholine mustard, showed approximately equal numbers of guanine nucleotide-sensitive high affinity (H) sites and guanine nucleotide-insensitive low affinity (L) sites. This 50% H phenomenon persisted in different buffers, at different temperatures, after the number of receptors was halved (and, thus, the remaining receptor to guanine nucleotide-binding protein ratio was doubled), after membrane solubilization with digitonin, and when rabbit cardiac membranes were used instead of rat brainstem membranes. Preferential occupation of H sites with acetylethylcholine mustard, and of L sites with quinuclidinyl benzilate or either mustard, yielded residual free receptor populations showing predominantly L and H sites, respectively. Low concentrations of (3H)-oxotremorine-M labeled only H sites, and the Bmax for these sites was 49% of the Bmax found with (3H)quinuclidinyl benzilate plus guanine nucleotide. These and other results are most consistent with the idea that H and L receptor sites exist on separate but dimeric receptor molecules and with the hypothesis that only the H receptors cycle between high and low affinity, depending upon interactions between this receptor molecule and a guanine nucleotide-binding protein.

  20. Multiple hypothesis clustering in radar plot extraction

    NARCIS (Netherlands)

    Huizing, A.G.; Theil, A.; Dorp, Ph. van; Ligthart, L.P.

    1995-01-01

    False plots and plots with inaccurate range and Doppler estimates may severely degrade the performance of tracking algorithms in radar systems. This paper describes how a multiple hypothesis clustering technique can be applied to mitigate the problems involved in plot extraction. The measures of

  1. Multiple hypothesis clustering in radar plot extraction

    NARCIS (Netherlands)

    Huizing, A.G.; Theil, A.; Dorp, Ph. van; Ligthart, L.P.

    1995-01-01

    False plots and plots with inaccurate range and Doppler estimates may severely degrade the performance of tracking algorithms in radar systems. This paper describes how a multiple hypothesis clustering technique can be applied to mitigate the problems involved in plot extraction. The measures of con

  2. A Conductive Gel for the Plotting of Equipotential Lines

    Science.gov (United States)

    Elizalde-Torres, J.; González-Cardel, M.; Vega-Murguía, E. J.; Castillo-González, I.; Rodríguez-Nava, M.

    2015-01-01

    This paper presents the development of a conductive gel that can be used to measure the electrical potential differences on its surface, and has enough consistency to plot equipotential lines. It has a gelation time of less than 10 min, and is suitable for implementing learning experiences in a physics teaching laboratory in a 90 min session. To…

  3. Fifth International Symposium on Recurrence Plot

    CERN Document Server

    Riley, Michael; Giuliani, Alessandro; Webber, Charles; Jr, Jr; Translational Recurrences : From Mathematical Theory to Real-World Applications

    2014-01-01

    This book features 13 papers presented at the Fifth International Symposium on Recurrence Plots, held August 2013 in Chicago, IL. It examines recent applications and developments in recurrence plots and recurrence quantifi cation analysis (RQA) with special emphasis on biological and cognitive systems and the analysis of coupled systems using cross-recurrence methods. Readers will discover new applications and insights into a range of systems provided by recurrence plot analysis and new theoretical and mathematical developments in recurrence plots. Recurrence plot based analysis is a powerful tool that operates on real-world complex systems that are nonlinear, non-stationary, noisy, of any statistical distribution, free of any particular model type, and not particularly long. Quantitative analyses promote the detection of system state changes, synchronized dynamical regimes, or classifi cation of system states. Th e book will be of interest to an interdisciplinary audience of recurrence plot users and researc...

  4. Faithfulness of Recurrence Plots: A Mathematical Proof

    Science.gov (United States)

    Hirata, Yoshito; Komuro, Motomasa; Horai, Shunsuke; Aihara, Kazuyuki

    It is practically known that a recurrence plot, a two-dimensional visualization of time series data, can contain almost all information related to the underlying dynamics except for its spatial scale because we can recover a rough shape for the original time series from the recurrence plot even if the original time series is multivariate. We here provide a mathematical proof that the metric defined by a recurrence plot [Hirata et al., 2008] is equivalent to the Euclidean metric under mild conditions.

  5. Adding stress plot function to NASTRAN

    Science.gov (United States)

    Katoh, S.

    1978-01-01

    Stress plot function was developed and added to the NASTRAN level 15.5. Computed stress distribution can be displayed by this function, with vectors showing the principal stresses of the finite elements over the specified portions of the structure. NASTRAN is reviewed in the aspect of plotting capabilities. Stress tensor field is examined in preparation of stress display. Then the stress plot function as added to the NASTRAN is described. A sample plotout by this function is shown.

  6. Porous Photocatalytic Membrane Microreactor (P2M2): A new reactor concept for photochemistry

    NARCIS (Netherlands)

    Aran, H.C.; Salamon, D.; Rijnaarts, T.; Mul, G.; Wessling, M.; Lammertink, R.G.H.

    2011-01-01

    In this study, a new membrane microreactor concept for multiphase photocatalytic reactions is demonstrated. Microfabrication, photocatalyst immobilization and surface modification steps were performed to develop a Porous Photocatalytic Membrane Microreactor (P2M2). This concept benefits from a stabl

  7. Porous Photocatalytic Membrane Microreactor (P2M2): A new reactor concept for photochemistry

    NARCIS (Netherlands)

    Aran, H.C.; Salamon, David; Rijnaarts, Timon; Rijnaarts, T.; Mul, Guido; Wessling, Matthias; Lammertink, Rob G.H.

    2011-01-01

    In this study, a new membrane microreactor concept for multiphase photocatalytic reactions is demonstrated. Microfabrication, photocatalyst immobilization and surface modification steps were performed to develop a Porous Photocatalytic Membrane Microreactor (P2M2). This concept benefits from a

  8. An Excel macro for generating trilinear plots.

    Science.gov (United States)

    Shikaze, Steven G; Crowe, Allan S

    2007-01-01

    This computer note describes a method for creating trilinear plots in Microsoft Excel. Macros have been created in MS Excel's internal language: Visual Basic for Applications (VBA). A simple form has been set up to allow the user to input data from an Excel worksheet. The VBA macro is used to convert the triangular data (which consist of three columns of percentage data) into X-Y data. The macro then generates the axes, labels, and grid for the trilinear plot. The X-Y data are plotted as scatter data in Excel. By providing this macro in Excel, users can create trilinear plots in a quick, inexpensive manner.

  9. Representing uncertainty on model analysis plots

    Science.gov (United States)

    Smith, Trevor I.

    2016-12-01

    Model analysis provides a mechanism for representing student learning as measured by standard multiple-choice surveys. The model plot contains information regarding both how likely students in a particular class are to choose the correct answer and how likely they are to choose an answer consistent with a well-documented conceptual model. Unfortunately, Bao's original presentation of the model plot did not include a way to represent uncertainty in these measurements. I present details of a method to add error bars to model plots by expanding the work of Sommer and Lindell. I also provide a template for generating model plots with error bars.

  10. Development and testing of a large, transportable rainfall simulator for plot-scale runoff and parameter estimation

    Directory of Open Access Journals (Sweden)

    T. G. Wilson

    2014-04-01

    Full Text Available There is increased interest in the interplay between vegetation conditions and overland flow generation. The literature is unclear on this relationship and there is little quantitative guidance for modeling efforts. Therefore, experimental efforts are needed and these call for a lightweight transportable plot-scale (>10 m2 rainfall simulator that can be deployed quickly and quickly redeployed over various vegetation cover conditions. Accordingly, a variable intensity rainfall simulator and collection system was designed and tested in the laboratory and in the field. The system was tested with three configurations of common pressure washing nozzles producing rainfall intensities of 62, 43, and 32 mm h−1 with uniformity coefficients of 76, 65, and 62, respectively, over a plot of 15.12 m2. Field tests were carried out in on a grassy field with silt-loam soil in Orroli, Sardinia in July and August 2010, and rainfall, soil moisture, and runoff data were collected. The two-term Philip infiltration model was used to find optimal values for the saturated hydraulic conductivity of the soil surface and bulk soil, soil water retention curve slope, and air entry suction head. Optimized hydraulic conductivity values were comparable to both the measured final infiltration rate and literature values for saturated hydraulic conductivity. This inexpensive rainfall simulator can therefore be used to identify field parameters needed for hydrologic modeling.

  11. A New method of preparing iso-hardness plots

    Science.gov (United States)

    Kumar, V.; Patwardhan, A. K.

    1993-02-01

    A new approach has been used for the preparation of iso-hardness plots, which are very useful in the heat treating of metals and alloys. An alloy white iron containing ~6% Mn, ~5% Cr, and ~3% Cu was heat treated at 800,850,900,950,1000, and 1050 °C and soaked for 2, 4, 6, 8, and 10 h, respectively, at each of these temperatures followed by air cooling. It was observed that, although the hardness varied linearly with soaking time, its variation with soaking temperature was nonlinear. This can be represented as: H = 98.285e2021.33/T + (0.037 - 0.316 × 10- 4 T) . t where H is Vickers hardness; T is soaking temperature in K; and t is soaking time in seconds. The variation in hardness has been discussed in light of microstructural changes that can take place upon heat treating. A three-dimensional plot of hardness, soaking temperature, and time was prepared based on the above equation. It revealed that the variation in hardness on heat treating can be represented as a surface instead of lines, where the change in the slope of the surface reflects the various transformations occurring in the alloy system. This iso- hardness plot, consisting of contours of constant hardness, has been prepared by projecting the above-mentioned surface on the soaking temperature- time plane. The method of selection of heat treating parameters based on this iso- hardness plot is discussed.

  12. Box Plots in the Australian Curriculum

    Science.gov (United States)

    Watson, Jane M.

    2012-01-01

    This article compares the definition of "box plot" as used in the "Australian Curriculum: Mathematics" with other definitions used in the education community; describes the difficulties students experience when dealing with box plots; and discusses the elaboration that is necessary to enable teachers to develop the knowledge…

  13. The Heuristic Interpretation of Box Plots

    Science.gov (United States)

    Lem, Stephanie; Onghena, Patrick; Verschaffel, Lieven; Van Dooren, Wim

    2013-01-01

    Box plots are frequently used, but are often misinterpreted by students. Especially the area of the box in box plots is often misinterpreted as representing number or proportion of observations, while it actually represents their density. In a first study, reaction time evidence was used to test whether heuristic reasoning underlies this…

  14. Reaction Order Ambiguity in Integrated Rate Plots

    Science.gov (United States)

    Lee, Joe

    2008-01-01

    Integrated rate plots are frequently used in reaction kinetics to determine orders of reactions. It is often emphasised, when using this methodology in practice, that it is necessary to monitor the reaction to a substantial fraction of completion for these plots to yield unambiguous orders. The present article gives a theoretical and statistical…

  15. Box Plots in the Australian Curriculum

    Science.gov (United States)

    Watson, Jane M.

    2012-01-01

    This article compares the definition of "box plot" as used in the "Australian Curriculum: Mathematics" with other definitions used in the education community; describes the difficulties students experience when dealing with box plots; and discusses the elaboration that is necessary to enable teachers to develop the knowledge necessary to use them…

  16. A Discussion on Mean Excess Plots

    CERN Document Server

    Ghosh, Souvik

    2009-01-01

    A widely used tool in the study of risk, insurance and extreme values is the mean excess plot. One use is for validating a Generalized Pareto model for the excess distribution. This paper investigates some theoretical and practical aspects of the use of the mean excess plot.

  17. Main: 1M2Q [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1M2Q トウモロコシ Corn Zea mays L. Casein Kinase Ii, Alpha Chain Name=Ack2; Zea Mays Mole...LVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTRA corn_1M2Q.jpg ...

  18. Main: 1M2P [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1M2P トウモロコシ Corn Zea mays L. Casein Kinase Ii, Alpha Chain Name=Ack2; Zea Mays Mole...LVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTRA corn_1M2P.jpg ...

  19. Main: 1M2R [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1M2R トウモロコシ Corn Zea mays L. Casein Kinase Ii, Alpha Chain Name=Ack2; Zea Mays Mole...ELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNVYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTRA corn_1M2R.jpg ...

  20. PlotStuff: A class for plotting stuff from overture based on: GL{underscore}GraphicsInterface: A graphics interface based on OpenGL based on: GenericGraphicsInterface: A generic graphics interface: User guide, Version 1.00

    Energy Technology Data Exchange (ETDEWEB)

    Henshaw, B.

    1996-10-16

    {bold PlotStuff} can be used to interactively plot objects from Overture such as mappings, grids and grid functions. PlotStuff can be used to plot contours, surfaces, streamlines and grids. It can also be used to plot one-dimensional line plots. {bold GL{emdash}GraphicsInterface} is a class (from which PlotStuff is derived) that implements some standard plotting functions using OpenGL. {bold GL{emdash}Graphicslnterface} is itself derived from the class GenericGraphicsInterface which defines some standard plotting functions that are independent of any particular graphics package.

  1. Surveillance of Site A and Plot M report for 2010.

    Energy Technology Data Exchange (ETDEWEB)

    Golchert, N. W. (ESQ)

    2011-05-31

    The results of the environmental surveillance program conducted at Site A/Plot M in the Palos Forest Preserve area for Calendar Year 2010 are presented. Based on the results of the 1976-1978 radiological characterization of the site, a determination was made that a surveillance program be established. The characterization study determined that very low levels of hydrogen-3 (as tritiated water) had migrated from the burial ground and were present in two nearby hand-pumped picnic wells. The current surveillance program began in 1980 and consists of sample collection and analysis of surface and subsurface water. The results of the analyses are used to monitor the migration pathway of hydrogen-3 contaminated water from the burial ground (Plot M) to the hand-pumped picnic wells and monitor for the presence of radioactive materials in the environment of the area. Hydrogen-3 in the Red Gate Woods picnic wells was still detected this year, but the average and maximum concentrations were significantly less than found earlier. Hydrogen-3 continues to be detected in a number of wells, boreholes, dolomite holes, and a surface stream. Analyses since 1984 have indicated the presence of low levels of strontium-90 in water from a number of boreholes next to Plot M. The results of the surveillance program continue to indicate that the radioactivity remaining at Site A/Plot M does not endanger the health or safety of the public visiting the site, using the picnic area, or living in the vicinity.

  2. Surveillance of Site A and Plot M, Report for 2009.

    Energy Technology Data Exchange (ETDEWEB)

    Golchert, N. W.

    2010-04-21

    The results of the environmental surveillance program conducted at Site A/Plot M in the Palos Forest Preserve area for Calendar Year 2009 are presented. Based on the results of the 1976-1978 radiological characterization of the site, a determination was made that a surveillance program be established. The characterization study determined that very low levels of hydrogen-3 (as tritiated water) had migrated from the burial ground and were present in two nearby hand-pumped picnic wells. The current surveillance program began in 1980 and consists of sample collection and analysis of surface and subsurface water. The results of the analyses are used to monitor the migration pathway of hydrogen-3 contaminated water from the burial ground (Plot M) to the hand-pumped picnic wells and monitor for the presence of radioactive materials in the environment of the area. Hydrogen-3 in the Red Gate Woods picnic wells was still detected this year, but the average and maximum concentrations were significantly less than found earlier. Hydrogen-3 continues to be detected in a number of wells, boreholes, dolomite holes, and a surface stream. Analyses since 1984 have indicated the presence of low levels of strontium-90 in water from a number of boreholes next to Plot M. The results of the surveillance program continue to indicate that the radioactivity remaining at Site A/Plot M does not endanger the health or safety of the public visiting the site, using the picnic area, or living in the vicinity.

  3. Stretched membrane heliostats: design and structural analysis of reflectance module and support of a heliostats of 9 m. diaform and 60 m''3 of reflectance surface; Diseno y analisis estructural del modulo reflectante y estructura soporte de un heliostato de 9 m. de diametro y 60 m2 de superficie reflectante

    Energy Technology Data Exchange (ETDEWEB)

    Figarola Torres, J. M.

    1993-07-01

    After having designed and built at CIEMAT a first prototype of a Btretched membrane heliostats of 3 m. diameter, the design and the structural analysis of the different components included in the reflectance module and support of another heliostats, this one of 9 m. diameter and 60 m2. of reflectance surface, are shown In this report. This last heliostats will be mounted on a pedestal and its driving device at the Solar Platform of Almeria. In order to optimize design and performance, the structural analysis of its basic components has been analyzed with the finite elements program ANSYS. The following elements have been subject to analysis: the membrane and their ring supports, stretching system and the structural support. A similar scheme to the one applied to the previous prototype has been used on the focus control system. That includes a linear transducer, a variable frequency and a fan. Finally it has to be pointed out that substantial improvements have been achieved with respect to the first prototype concerning design and cost. (Author) 5 refs.

  4. Correlations in Nuclear Arrhenius-Type Plots

    CERN Document Server

    Tsang, M B

    1998-01-01

    Arrhenius-type plots for multifragmentation process, defined as the transverse energy dependence of the single-fragment emission-probability, -ln(p_{b}) vs 1/sqrt(E_{t}), have been studied by examining the relationship of the parameters p_{b} and E_{t} to the intermediate-mass fragment multiplicity . The linearity of these plots reflects the correlation of the fragment multiplicity with the transverse energy. These plots may not provide thermal scaling information about fragment production as previously suggested.

  5. Magnetic and Mechanical Properties of Hard Magnetic Alloys 30Kh21K3M and 30Kh20K2M2V

    Science.gov (United States)

    Stel'mashok, S. I.; Milyaev, I. M.; Yusupov, V. S.; Milyaev, A. I.

    2017-01-01

    The magnetic and mechanical properties of two hard magnetic alloys (30Kh21K3M and 30Kh20K2M2V) of the Fe - Cr - Co system in anisotropic and isotropic conditions produced by traditional induction melting and by the method of powder metallurgy with subsequent pressure treatment of the metal are studied. The obtained regression equations for B r , H cB and ( BH )max describe the quantities adequately in the used range of variation of factors. The response surfaces and their sections in the phase space of the heat treatment factors are plotted. The results of the analysis of the proportion of residual induction in anisotropic and isotropic states are used to infer that the model of the mechanism of magnetization reversal of hard magnetic alloys of the class considered needs amending.

  6. Split-plot designs for multistage experimentation

    DEFF Research Database (Denmark)

    Kulahci, Murat; Tyssedal, John

    2016-01-01

    at the same time will be more efficient. However, there have been only a few attempts in the literature to provide an adequate and easy-to-use approach for this problem. In this paper, we present a novel methodology for constructing two-level split-plot and multistage experiments. The methodology is based...... be accommodated in each stage. Furthermore, split-plot designs for multistage experiments with good projective properties are also provided....

  7. PRP: a FORTRAN IV interactive plotting program

    Science.gov (United States)

    Andrew, A. S.; Linde, J.

    A computer program, PRP, has been designed to plot any arithmetic combination selected from a set of major and trace element data on a y- x graph. y and x are defined and entered as a program string (y, x) which is interpreted sequentially. Operators ( +, -, ∗, /, ( unary) , square root, log 10, In c, antilog 10, exponential, integer, absolute value, (,),,) and integer or real numbers may be included. Axis lengths and scales are determined by the user. Five different plotting symbols are available.

  8. Generalised Recurrence Plot Analysis for Spatial Data

    OpenAIRE

    Marwan, Norbert; Kurths, Juergen; Saparin, Peter

    2006-01-01

    Recurrence plot based methods are highly efficient and widely accepted tools for the investigation of time series or one-dimensional data. We present an extension of the recurrence plots and their quantifications in order to study recurrent structures in higher-dimensional spatial data. The capability of this extension is illustrated on prototypical 2D models. Next, the tested and proved approach is applied to assess the bone structure from CT images of human proximal tibia. We find that the ...

  9. Development of TRatioPlot in ROOT

    CERN Document Server

    Gessinger-Befurt, Paul

    2016-01-01

    The ROOT data analysis and visualization framework is a software package which is widely used in physics, especially in high energy physics. A common visualization which has so far been lacking a direct implementation is the ratio plot, as well as a few similar types of plots. The scope and goal of the summer student project at CERN was to implement a class in ROOT itself, that can take care of the most common types of calculations, and produces high quality visuals.

  10. A humanized anti-M2 scFv shows protective in vitro activity against influenza

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Andrew M [Los Alamos National Laboratory; Velappan, Nileena [Los Alamos National Laboratory; Schmidt, Jurgen G [Los Alamos National Laboratory

    2008-01-01

    M2 is one of the most conserved influenza proteins, and has been widely prospected as a potential universal vaccine target, with protection predominantly mediated by antibodies. In this paper we describe the creation of a humanized single chain Fv from 14C2, a potent monoclonal antibody against M2. We show that the humanized scFv demonstrates similar activity to the parental mAb: it is able to recognize M2 in its native context on cell surfaces and is able to show protective in vitro activity against influenza, and so represents a potential lead antibody candidate for universal prophylactic or therapeutic intervention in influenza.

  11. Modelling runoff at the plot scale taking into account rainfall partitioning by vegetation: application to stemflow of banana (Musa spp. plant

    Directory of Open Access Journals (Sweden)

    Y.-M. Cabidoche

    2009-06-01

    Full Text Available Rainfall partitioning by vegetation modifies the intensity of rainwater reaching the ground, which affects runoff generation. Incident rainfall is intercepted by the plant canopy and then redistributed into throughfall and stemflow. Rainfall intensities at the soil surface are therefore not spatially uniform, generating local variations of runoff production that are disregarded in runoff models. The aim of this paper was to model runoff at the plot scale, accounting for rainfall partitioning by vegetation in the case of plants concentrating rainwater at the plant foot and promoting stemflow. We developed a lumped modelling approach, including a stemflow function that divided the plot into two compartments: one compartment including stemflow and the relative water pathways and one compartment for the rest of the plot. This stemflow function was coupled with a production function and a transfer function to simulate a flood hydrograph using the MHYDAS model. Calibrated parameters were a "stemflow coefficient", which compartmented the plot; the saturated hydraulic conductivity (Ks, which controls infiltration and runoff; and the two parameters of the diffusive wave equation. We tested our model on a banana plot of 3000 m2 on permeable Andosol (mean Ks=75 mm h−1 under tropical rainfalls, in Guadeloupe (FWI. Runoff simulations without and with the stemflow function were performed and compared to 18 flood events from 10 to 130 mm rainfall depth. Modelling results showed that the stemflow function improved the calibration of hydrographs according to the error criteria on volume and on peakflow and to the Nash and Sutcliffe coefficient. This was particularly the case for low flows observed during residual rainfall, for which the stemflow function allowed runoff to be simulated for rainfall intensities lower than the Ks measured at the soil surface. This approach also allowed us to take into account the experimental data, without needing to calibrate

  12. Towards Horizontal Architecture for Autonomic M2M Service Networks

    Directory of Open Access Journals (Sweden)

    Juhani Latvakoski

    2014-05-01

    Full Text Available Today, increasing number of industrial application cases rely on the Machine to Machine (M2M services exposed from physical devices. Such M2M services enable interaction of physical world with the core processes of company information systems. However, there are grand challenges related to complexity and “vertical silos” limiting the M2M market scale and interoperability. It is here expected that horizontal approach for the system architecture is required for solving these challenges. Therefore, a set of architectural principles and key enablers for the horizontal architecture have been specified in this work. A selected set of key enablers called as autonomic M2M manager, M2M service capabilities, M2M messaging system, M2M gateways towards energy constrained M2M asset devices and creation of trust to enable end-to-end security for M2M applications have been developed. The developed key enablers have been evaluated separately in different scenarios dealing with smart metering, car sharing and electric bike experiments. The evaluation results shows that the provided architectural principles, and developed key enablers establish a solid ground for future research and seem to enable communication between objects and applications, which are not initially been designed to communicate together. The aim as the next step in this research is to create a combined experimental system to evaluate the system interoperability and performance in a more detailed manner.

  13. Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor

    OpenAIRE

    Wymke Ockenga; Ritva Tikkanen

    2015-01-01

    The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family. The uptake of the M2 receptor involves the adapter proteins of the β-arrestin family and the small GTPase ADP-ribosylation factor 6. However, it has remained inconclusive if M2 endocytosis is dependent on clathrin or the large GTPase dynamin. We here show by means of knocking down the clathrin heavy chain that M2 uptake upon agonist stimul...

  14. The Demand for Divisia M2 in China%中国Divisa M2需求模型

    Institute of Scientific and Technical Information of China (English)

    潘红宇; 邓述慧

    2001-01-01

    本文计算中国Divisa M2指数并对其建立需求模型,研究发现实际Divisa M2 与实际产出存在协整关系,采用误差校正方法建立的动态需求模型具有良好的稳定性。%This paper computes the Divisa M2 in China and makes the money demand model for it. The research finds that the demand for real Divisa M2 is cointegrated with the real output, the short-run model is stable also.

  15. A Survey on M2M Service Networks

    Directory of Open Access Journals (Sweden)

    Juhani Latvakoski

    2014-11-01

    Full Text Available The number of industrial applications relying on the Machine to Machine (M2M services exposed from physical world has been increasing in recent years. Such M2M services enable communication of devices with the core processes of companies. However, there is a big challenge related to complexity and to application-specific M2M systems called “vertical silos”. This paper focuses on reviewing the technologies of M2M service networks and discussing approaches from the perspectives of M2M information and services, M2M communication and M2M security. Finally, a discussion on technologies and approaches potentially enabling future autonomic M2M service networks are provided. According to our conclusions, it is seen that clear definition of the architectural principles is needed to solve the “vertical silo” problem and then, proceeding towards enabling autonomic capabilities for solving complexity problem appears feasible. Several areas of future research have been identified, e.g., autonomic information based services, optimization of communications with limited capability devices, real-time messaging, creation of trust and end to end security, adaptability, reliability, performance, interoperability, and maintenance.

  16. M2 factor of four-petal Gaussian beam

    Institute of Scientific and Technical Information of China (English)

    Zhou Guo-Quan; Fan Yan

    2008-01-01

    Based on the second-order moments,this paper derives an analytical expression of the M2 factor of four-petal Gaussian beam.The results show that the M2 factor is only determined by the beam order n.The corresponding numerical calculations are also given.As the beam order increases,the augment of M2 factor is disciplinary.As the expression of M2 factor is expressed in series form and becomes more complicated,a new concise formula of M2 factor is also presented by using curve fitting of numerical calculations.When 3≤n≤200,the maximum error rate of fitting formula will not exceed 2.6% and the average error rate is 0.28%.This research is helpful to the applications of four-petal Gaussian beam.

  17. 6th International Symposium on Recurrence Plots

    CERN Document Server

    Jr, Jr; Ioana, Cornel; Marwan, Norbert

    2016-01-01

    The chapters in this book originate from the research work and contributions presented at the Sixth International Symposium on Recurrence Plots held in Grenoble, France in June 2015. Scientists from numerous disciplines gathered to exchange knowledge on recent applications and developments in recurrence plots and recurrence quantification analysis. This meeting was remarkable because of the obvious expansion of recurrence strategies (theory) and applications (practice) into ever-broadening fields of science. It discusses real-world systems from various fields, including mathematics, strange attractors, applied physics, physiology, medicine, environmental and earth sciences, as well as psychology and linguistics. Even readers not actively researching any of these particular systems will benefit from discovering how other scientists are finding practical non-linear solutions to specific problems. The book is of interest to an interdisciplinary audience of recurrence plot users and researchers interested in time...

  18. BOREAS TE-23 Map Plot Data

    Science.gov (United States)

    Rich, Paul M.; Fournier, Robert; Hall, Forrest G. (Editor); Papagno, Andrea (Editor)

    2000-01-01

    The Boreal Ecosystem-Atmospheric Study (BOREAS) TE-23 (Terrestrial Ecology) team collected map plot data in support of its efforts to characterize and interpret information on canopy architecture and understory cover at the BOREAS tower flux sites and selected auxiliary sites from May to August 1994. Mapped plots (typical dimensions 50 m x 60 m) were set up and characterized at all BOREAS forested tower flux and selected auxiliary sites. Detailed measurement of the mapped plots included: (1) stand characteristics (location, density, basal area); (2) map locations diameter at breast height (DBH) of all trees; (3) detailed geometric measures of a subset of trees (height, crown dimensions); and (4) understory cover maps. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  19. Application of mapped plots for single-owner forest surveys

    Science.gov (United States)

    Paul C. Van Deusen; Francis Roesch

    2009-01-01

    Mapped plots are used for the nation forest inventory conducted by the U.S. Forest Service. Mapped plots are also useful foro single ownership inventoires. Mapped plots can handle boundary overlap and can aprovide less variable estimates for specified forest conditions. Mapping is a good fit for fixed plot inventories where the fixed area plot is used for both mapping...

  20. M2 polarization enhances silica nanoparticle uptake by macrophages

    Directory of Open Access Journals (Sweden)

    Jessica eHoppstädter

    2015-03-01

    Full Text Available While silica nanoparticles have enabled numerous industrial and medical applications, their toxicological safety requires further evaluation. Macrophages are the major cell population responsible for nanoparticle clearance in vivo. The prevailing macrophage phenotype largely depends on the local immune status of the host. Whereas M1-polarized macrophages are considered as pro-inflammatory macrophages involved in host defense, M2 macrophages exhibit anti-inflammatory and wound-healing properties, but also promote tumor growth.We employed different models of M1 and M2 polarization: GM-CSF/LPS/IFN-gamma was used to generate primary human M1 cells and M-CSF/IL-10 to differentiate M2 monocyte-derived macrophages. PMA-differentiated THP-1 cells were polarized towards an M1 type by LPS/IFN-gamma and towards M2 by IL-10. Uptake of fluorescent silica nanoparticles (Ø 26 and 41 nm and microparticles (Ø 1.75 µm was quantified. At the concentration used (50 µg/ml, silica nanoparticles did not influence cell viability as assessed by MTT assay. Nanoparticle uptake was enhanced in M2-polarized primary human monocyte-derived macrophages compared with M1 cells, as shown by flow cytometric and microscopic approaches. In contrast, the uptake of microparticles did not differ between M1 and M2 phenotypes. M2 polarization was also associated with increased nanoparticle uptake in the macrophage-like THP-1 cell line. In accordance, in vivo polarized M2-like primary human tumor-associated macrophages (TAM obtained from lung tumors took up more nanoparticles than M1-like alveolar macrophages isolated from the surrounding lung tissue.In summary, our data indicate that the M2 polarization of macrophages promotes nanoparticle internalization. Therefore, the phenotypical differences between macrophage subsets should be taken into consideration in future investigations on nanosafety, but might also open up therapeutic perspectives allowing to specifically target M2

  1. PLOT3D Export Tool for Tecplot

    Science.gov (United States)

    Alter, Stephen

    2010-01-01

    The PLOT3D export tool for Tecplot solves the problem of modified data being impossible to output for use by another computational science solver. The PLOT3D Exporter add-on enables the use of the most commonly available visualization tools to engineers for output of a standard format. The exportation of PLOT3D data from Tecplot has far reaching effects because it allows for grid and solution manipulation within a graphical user interface (GUI) that is easily customized with macro language-based and user-developed GUIs. The add-on also enables the use of Tecplot as an interpolation tool for solution conversion between different grids of different types. This one add-on enhances the functionality of Tecplot so significantly, it offers the ability to incorporate Tecplot into a general suite of tools for computational science applications as a 3D graphics engine for visualization of all data. Within the PLOT3D Export Add-on are several functions that enhance the operations and effectiveness of the add-on. Unlike Tecplot output functions, the PLOT3D Export Add-on enables the use of the zone selection dialog in Tecplot to choose which zones are to be written by offering three distinct options - output of active, inactive, or all zones (grid blocks). As the user modifies the zones to output with the zone selection dialog, the zones to be written are similarly updated. This enables the use of Tecplot to create multiple configurations of a geometry being analyzed. For example, if an aircraft is loaded with multiple deflections of flaps, by activating and deactivating different zones for a specific flap setting, new specific configurations of that aircraft can be easily generated by only writing out specific zones. Thus, if ten flap settings are loaded into Tecplot, the PLOT3D Export software can output ten different configurations, one for each flap setting.

  2. CEMS-investigations of AISI M2 steel after nitrogen plasma immersion ion implantation

    Energy Technology Data Exchange (ETDEWEB)

    Uglov, V.V. E-mail: info@research.bsu.unibel.by; Kholmetskii, A.L.; Kuleshov, A.K.; Fedotova, J.A.; Rusalsky, D.P.; Khodasevich, V.V.; Ruebenbauer, K.; Richter, E.; Guenzel, R.; Parascandola, S

    1999-01-02

    Plasma-immersion ion implantation (PIII) and high-current ion implantation (HCII) of nitrogen into M2 steel were carried out. The formation of a multilayer system consisting of a surface layer of austenite on top of {epsilon}-Fe{sub 3}N nitride precipitates was manifested in M2 steel after PIII. HCII forms a thick (more than 14 {mu}m) layer with {epsilon}-Fe{sub 3}N precipitates. Apparently, the formation of the austenite layer after PIII is connected with a local tempering of the steel surface by the pulsed nitrogen ion beam.

  3. Generalised recurrence plot analysis for spatial data

    Energy Technology Data Exchange (ETDEWEB)

    Marwan, Norbert [Institute of Physics, University of Potsdam, 14415 Potsdam (Germany)]. E-mail: marwan@agnld.uni-potsdam.de; Kurths, Juergen [Institute of Physics, University of Potsdam, 14415 Potsdam (Germany); Saparin, Peter [Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam-Golm (Germany)

    2007-01-08

    Recurrence plot based methods are highly efficient and widely accepted tools for the investigation of time series or one-dimensional data. We present an extension of the recurrence plots and their quantifications in order to study recurrent structures in higher-dimensional spatial data. The capability of this extension is illustrated on prototypical 2D models. Next, the tested and proved approach is applied to assess the bone structure from CT images of human proximal tibia. We find that the spatial structures in trabecular bone become more recurrent during the bone loss in osteoporosis.

  4. Surveillance of Site A and Plot M - Report for 2006.

    Energy Technology Data Exchange (ETDEWEB)

    Golchert, N. W.; ESH/QA Oversight

    2007-05-07

    The results of the environmental surveillance program conducted at Site A/Plot M in the Palos Forest Preserve area for Calendar Year 2006 are presented. Based on the results of the 1976-1978 radiological characterization of the site, a determination was made that a surveillance program be established. The characterization study determined that very low levels of hydrogen-3 (as tritiated water) had migrated from the burial ground and were present in two nearby hand-pumped picnic wells. The current surveillance program began in 1980 and consists of sample collection and analysis of surface and subsurface water. The results of the analyses are used to (1) monitor the migration pathway of water from the burial ground (PlotM) to the hand pumped picnic wells, (2) establish if buried radionuclides other than hydrogen-3 have migrated, and (3) monitor the presence of radioactive and chemically hazardous materials in the environment of the area. Hydrogen-3 in the Red GateWoods picnic wells was still detected this year, but the average and maximum concentrations were significantly less than found earlier. Hydrogen-3 continues to be detected in a number of wells, boreholes, dolomite holes, and a surface stream. Analyses since 1984 have indicated the presence of low levels of strontium-90 in water from a number of boreholes next to Plot M. The results of the surveillance program continue to indicate that the radioactivity remaining at Site A/Plot M does not endanger the health or safety of the public visiting the site, using the picnic area, or living in the vicinity.

  5. Surveillance of Site A and Plot M, Report for 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Golchert, N. W.

    2009-05-07

    The results of the environmental surveillance program conducted at Site A/Plot M in the Palos Forest Preserve area for Calendar Year 2008 are presented. Based on the results of the 1976-1978 radiological characterization of the site, a determination was made that a surveillance program be established. The characterization study determined that very low levels of hydrogen-3 (as tritiated water) had migrated from the burial ground and were present in two nearby hand pumped picnic wells. The current surveillance program began in 1980 and consists of sample collection and analysis of surface and subsurface water. The results of the analyses are used to (1) monitor the migration pathway of hydrogen-3 contaminated water from the burial ground (Plot M) to the hand-pumped picnic wells, (2) establish if other buried radionuclides have migrated, and (3) monitor for the presence of radioactive materials in the environment of the area. Hydrogen-3 in the Red Gate Woods picnic wells was still detected this year, but the average and maximum concentrations were significantly less than found earlier. Hydrogen-3 continues to be detected in a number of wells, boreholes, dolomite holes, and a surface stream. Analyses since 1984 have indicated the presence of low levels of strontium-90 in water from a number of boreholes next to Plot M. The results of the surveillance program continue to indicate that the radioactivity remaining at Site A/Plot M does not endanger the health or safety of the public visiting the site, using the picnic area, or living in the vicinity.

  6. Surveillance of site A and plot M, report for 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Golchert, N. W.; ESH/QA Oversight

    2008-03-25

    The results of the environmental surveillance program conducted at Site A/Plot M in the Palos Forest Preserve area for Calendar Year 2007 are presented. Based on the results of the 1976-1978 radiological characterization of the site, a determination was made that a surveillance program be established. The characterization study determined that very low levels of hydrogen-3 (as tritiated water) had migrated from the burial ground and were present in two nearby hand pumped picnic wells. The current surveillance program began in 1980 and consists of sample collection and analysis of surface and subsurface water. The results of the analyses are used to: (1) monitor the migration pathway of water from the burial ground (Plot M) to the hand-pumped picnic wells, (2) establish if other buried radionuclides have migrated, and (3) monitor the presence of radioactive materials in the environment of the area. Hydrogen-3 in the Red Gate Woods picnic wells was still detected this year, but the average and maximum concentrations were significantly less than found earlier. Hydrogen-3 continues to be detected in a number of wells, boreholes, dolomite holes, and a surface stream. Analyses since 1984 have indicated the presence of low levels of strontium-90 in water from a number of boreholes next to Plot M. The results of the surveillance program continue to indicate that the radioactivity remaining at Site A/Plot M does not endanger the health or safety of the public visiting the site, using the picnic area, or living in the vicinity.

  7. A reduced volumetric expansion factor plot

    Science.gov (United States)

    Hendricks, R. C.

    1979-01-01

    A reduced volumetric expansion factor plot has been constructed for simple fluids which is suitable for engineering computations in heat transfer. Volumetric expansion factors have been found useful in correlating heat transfer data over a wide range of operating conditions including liquids, gases and the near critical region.

  8. 无缝衔接下的错乱情节——《献给爱米丽的玫瑰》的衔接和连贯分析%The Disordered Plot under the Highly Cohesive Surface Structure——An analysis of cohesion and coherence in A Rose for Emily

    Institute of Scientific and Technical Information of China (English)

    张志敏

    2012-01-01

    A Rose for Emily is highly cohesive,but under the tight structure is the disordered arrangement of incidents.The cohesion of and within different parts of the story builds up the surface unity of the text,but does not contribute to the coherence of the story.To achieve the unity and coherence of the story,the reader should integrate the disordered plot and make further analysis,inferences and evaluation through the broken pieces of the plot.The inconsistency of the surface structure and the inner structure requires the reader to actively participate in the construction and interpretation of the story.The relation between cohesion and coherence in A rose for Emily reflects the text feature of modernistic fiction.%《献给爱米丽的玫瑰》各部分之间的衔接可谓天衣无缝,但在这种无缝衔接的下面却是事件的错乱安排。情节是读者获取小说连贯或主题的重要依据。可以说,衔接把错乱的情节缝合在了一起,但并没有促成小说的连贯。要获取小说的连贯,了解故事的真相,读者需要重新审视错乱的情节,按照时间先后重新排序。《献给爱米丽的玫瑰》中的衔接和连贯的反常规关系体现了现代小说的构篇特点。

  9. TNF Counterbalances the Emergence of M2 Tumor Macrophages

    Directory of Open Access Journals (Sweden)

    Franz Kratochvill

    2015-09-01

    Full Text Available Cancer can involve non-resolving, persistent inflammation where varying numbers of tumor-associated macrophages (TAMs infiltrate and adopt different activation states between anti-tumor M1 and pro-tumor M2 phenotypes. Here, we resolve a cascade causing differential macrophage phenotypes in the tumor microenvironment. Reduction in TNF mRNA production or loss of type I TNF receptor signaling resulted in a striking pattern of enhanced M2 mRNA expression. M2 gene expression was driven in part by IL-13 from eosinophils co-recruited with inflammatory monocytes, a pathway that was suppressed by TNF. Our data define regulatory nodes within the tumor microenvironment that balance M1 and M2 populations. Our results show macrophage polarization in cancer is dynamic and dependent on the balance between TNF and IL-13, thus providing a strategy for manipulating TAMs.

  10. TNF counterbalances the emergence of M2 tumor macrophages

    Science.gov (United States)

    Kratochvill, Franz; Neale, Geoffrey; Haverkamp, Jessica M.; de Velde, Lee-Ann Van; Smith, Amber M.; Kawauchi, Daisuke; McEvoy, Justina; Roussel, Martine F.; Dyer, Michael A.; Qualls, Joseph E.; Murray, Peter J.

    2015-01-01

    Cancer is a form of non-resolving, persistent inflammation where varying numbers of tumor-associated macrophages (TAMs) infiltrate and adopt different activation states between anti-tumor M1 and pro-tumor M2 phenotypes. Here we resolve a cascade causing differential macrophage phenotypes in the tumor microenvironment. Reduction in TNF mRNA production or loss of Type I TNF receptor signaling resulted in a striking pattern of enhanced M2 mRNA expression. M2 gene expression was driven in part by IL-13 from eosinophils co-recruited with inflammatory monocytes, a pathway that was suppressed by TNF. Our data define regulatory nodes within the tumor microenvironment that balance M1 and M2 populations. Our results show macrophage polarization in cancer is dynamic and dependent on the balance between TNF and IL-13, thus providing a strategy for manipulating TAMs. PMID:26365184

  11. Multiple Access Technologies for Cellular M 2M Communications

    Institute of Scientific and Technical Information of China (English)

    Mahyar Shirvanimoghaddam; Sarah J. Johnson

    2016-01-01

    This paper reviews the multiple access techniques for machine⁃to⁃machine (M2M) communications in future wireless cellular net⁃works. M2M communications aims at providing the communication infrastructure for the emerging Internet of Things (IoT), which will revolutionize the way we interact with our surrounding physical environment. We provide an overview of the multiple access strategies and explain their limitations when used for M2M communications. We show the throughput efficiency of different multi⁃ple access techniques when used in coordinated and uncoordinated scenarios. Non⁃orthogonal multiple access (NOMA) is also shown to support a larger number of devices compared to orthogonal multiple access techniques, especially in uncoordinated sce⁃narios. We also detail the issues and challenges of different multiple access techniques to be used for M2M applications in cellu⁃lar networks.

  12. Theoretical Assessment of 178m2Hf De-Excitation

    Energy Technology Data Exchange (ETDEWEB)

    Hartouni, E P; Chen, M; Descalle, M A; Escher, J E; Loshak, A; Navratil, P; Ormand, W E; Pruet, J; Thompson, I J; Wang, T F

    2008-10-06

    This document contains a comprehensive literature review in support of the theoretical assessment of the {sup 178m2}Hf de-excitation, as well as a rigorous description of controlled energy release from an isomeric nuclear state.

  13. Long-term trends of plot-scale Cs-137 wash-off from various land uses in Fukushima

    Science.gov (United States)

    Wakiyama, Yoshifumi; Onda, Yuichi; Yoshimura, Kazuya; Nakamura, Noriko; Manome, Ryo

    2016-04-01

    Understanding plot-scale Cs-137 wash-off is indispensable for predicting Cs-137 fate. However, there are only a few numbers of long-term observations and hence lack of information on temporal trends of Cs-137 wash-off leaves uncertainties on future predictions. This study shows approximately three years' observation results of plot-scale Cs-137 wash-off from various land uses after the accident of Fukushima Dai-ichi Nuclear Power Plant. Erosion plots were established in 2011 and 2013 on two uncultivated farmlands (FL-A1, FL-B1), two cultivated farmlands (FL-A2, FL-B2), three grasslands (GL-A, GL-B, GL-C) and one Japanese cedar forest (JCdF) in Kawamata town. Each erosion plot consisted of eroding surface with length of 22.13 m and width of 5 m, surface water monitoring apparatus at the outlet of eroding surface and sediment traps. Sediment traps were connected with pipes in series and it enabled us to collect deposited sediments and suspended sediments separately. Eroded sediments as well as the data of rainfall and vegetation cover were collected almost every two weeks. Collected deposited and suspended sediment were dried, weighed and measured with HPGe type gamma detectors for Cs-137 concentrations. Standardized Cs-137 concentration, Sc (m2/kg), was calculated by dividing Cs-137 concentration by initial Cs-137 deposition. Annual soil loss ranged from 0.04 to 75 t/ha/year and the largest was from FL-A2 followed by FL-B2, FL-A1, FL-B1, GL-A, GL-B, JCdF and then GL-C. Soil erosion rate were positively correlated with mean values of vegetation cover on undisturbed soils, whereas high erosion rate were found on cultivated farmlands compared with even with similar vegetation cover to uncultivated farmlands. Concentrations of Cs-137 in eroded sediments ranged from the order of 103 to 105 Bq/kg and basically depended on the initial Cs-137 deposition. Sediment amount weighted mean values Sc ranged from 0.0062 to 0.084 m2/kg and the largest was from JCdF followed by FL-B1

  14. Characterization of M2 antibodies in asymptomatic Chinese population

    Institute of Scientific and Technical Information of China (English)

    Xiao-Hua Jiang; Ren-Qian Zhong; Xiao-Yun Fan; Yin Hu; Feng An; Jian-Wen Sun; Xian-Tao Kong

    2003-01-01

    AIM: To investigate the presence of M2 antibodies specific for pdmary biliary cirrhosis (PBC) in asymptomatic Chinese and identify patients with early PBC.METHODS: Enzyme-linked immunosorbent assay (ElISA)tests for M2 antibodies to recombinant protein were performed in 5 011 subjects (age range, 26-85 years; mean age: 45.81±15.02 years) who took an annual physical examination. M2-positive subjects were further analyzed for immunoglobulin (Ig) classes and subclasses of M2 antibodies.Clinical, biochemical and immunological data were obtained for M2-positive subjects. In addition, ultrasonography (US)or endoscopic retrograde cholangio-pancreatography (ERCP)was performed to exclude any disorders other than PBC.RESULTS: M2 antibodies were detected in 8 (0.16%) of the 5 0LL subjects studied. Of the 8 subjects, 7 were female and 1 was male (age range: 40-74 years). An unexplained increase of serum alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (γ-GT) values, often to striking levels,was detected in 4 M2-positive subjects, 3 of them accorded with the diagnostic criteria recommended by the American Association for the Study of Liver Diseases, even though they had no symptoms of PBC (such as fatigue, pruritus or jaundice).Liver biopsy was performed in two M2-positive subjects and the histology was compatible with PBC in both cases.CONCLUSION: Our data, while not assessing the true prevalence of asymptomatic PBC in the general population,suggest that asymptomatic PBC is much more common in China than has been supposed.

  15. M2-Edge Colorings Of Cacti And Graph Joins

    Directory of Open Access Journals (Sweden)

    Czap Július

    2016-02-01

    Full Text Available An edge coloring φ of a graph G is called an M2-edge coloring if |φ(v| ≤ 2 for every vertex v of G, where φ(v is the set of colors of edges incident with v. Let 2(G denote the maximum number of colors used in an M2-edge coloring of G. In this paper we determine 2(G for trees, cacti, complete multipartite graphs and graph joins.

  16. A comparison of trenched plot techniques for partitioning soil respiration

    Energy Technology Data Exchange (ETDEWEB)

    Bond-Lamberty, Benjamin; Bronson, Dustin; Bladyka, Emma; Gower, Stith T.

    2011-07-16

    Partitioning the soil surface CO{sub 2} flux (R{sub S}) flux is an important step in understanding ecosystem-level carbon cycling, given that R{sub S} is poorly constrained and its source components may have different responses to climate change. Trenched plots are a classic method of separating the R{sub S} source fluxes, but labor-intensive and may cause considerable disturbance to the soil environment. This study tested if various methods of plant suppression in trenched plots affected R{sub S} fluxes, quantified the R{sub S} response to soil temperature and moisture changes, and estimated the heterotrophic contribution to R{sub S}. It was performed in a boreal black spruce (Picea mariana) plantation, using a complete randomized design, during the 2007 growing season (May-November). Trenched plots had significantly lower R{sub S} than control plots, with differences appearing {approx}100 days after trenching; spatial variability doubled after trenching but then declined throughout the experiment. Most trenching treatments had significantly lower (by {approx}0.5 {mu}mol m{sup -2} s{sup -1}) R{sub S} than the controls, and there was no significant difference in R{sub S} among the various trenching treatments. Soil temperature at 2 cm explained more R{sub S} variability than did 10-cm temperature or soil moisture. Temperature sensitivity (Q10) declined in the control plots from {approx}2.6 (at 5 C) to {approx}1.6 (at 15 C); trenched plots values were higher, from 3.1 at 5 C to 1.9 at 15 C. We estimated R{sub S} for the study period to be 241 {+-} 40 g C m{sup -2}, with roots contributing 64% of R{sub S} after accounting for fine root decay, and 293 g C m{sup -2} for the entire year. These findings suggest that laborious hand weeding of vegetation may be usefully replaced by other methods, easing future studies of this large and poorly-understood carbon flux.

  17. Study of {sup 179}Hf{sup m2} excitation

    Energy Technology Data Exchange (ETDEWEB)

    Vishnevsky, I. N.; Zheltonozhsky, V. A., E-mail: zhelton@kinr.kiev.ua; Savrasov, A. N. [National Academy of Sciences of Ukraine, Institute for Nuclear Research (Ukraine); Mazur, V. M. [National Academy of Sciences of Ukraine, Institute of Electronic Physics (Ukraine)

    2016-12-15

    Isomeric ratios of {sup 179}Hf{sup m2,g} yields in the (γ, n) reaction and the cross section for the {sup 179}Hf{sup m2} population in the (α, p) reaction are measured for the first time at the end-point energies of 15.1 and 17.5 MeV for bremsstrahlung photons and 26 MeV for alpha particles. The results are σ = (1.1 ± 0.11) × 10{sup −27} cm{sup 2} for the {sup 176}Lu(α, p){sup 179}Hf{sup m2} reaction and Y{sub m2}/Y{sub g} = (6.1 ± 0.3) × 10{sup −6} and (3.7 ± 0.2) × 10{sup −6} for the {sup 180}Hf(γ, n){sup 179}Hf{sup m22} reaction at E{sub ep} =15.1 and 17.5 MeV, respectively. The experimental data on the relative {sup 179}Hf{sup m2} yield indicate a single-humped shape of the excitation function for the {sup 180}Hf(γ, n){sup 179}Hf{sup m2} reaction. Simulation is performed using the TALYS-1.4 and EMPIRE-3.2 codes.

  18. Revisiting the endocytosis of the m2 muscarinic acetylcholine receptor.

    Science.gov (United States)

    Ockenga, Wymke; Tikkanen, Ritva

    2015-05-12

    The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family. The uptake of the M2 receptor involves the adapter proteins of the β-arrestin family and the small GTPase ADP-ribosylation factor 6. However, it has remained inconclusive if M2 endocytosis is dependent on clathrin or the large GTPase dynamin. We here show by means of knocking down the clathrin heavy chain that M2 uptake upon agonist stimulation requires clathrin. The expression of various dominant-negative dynamin-2 mutants and the use of chemical inhibitors of dynamin function revealed that dynamin expression and membrane localization as such appear to be necessary for M2 endocytosis, whereas dynamin GTPase activity is not required for this process. Based on the data from the present and from previous studies, we propose that M2 endocytosis takes place by means of an atypical clathrin-mediated pathway that may involve a specific subset of clathrin-coated pits/vesicles.

  19. Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor

    Directory of Open Access Journals (Sweden)

    Wymke Ockenga

    2015-05-01

    Full Text Available The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family. The uptake of the M2 receptor involves the adapter proteins of the β-arrestin family and the small GTPase ADP-ribosylation factor 6. However, it has remained inconclusive if M2 endocytosis is dependent on clathrin or the large GTPase dynamin. We here show by means of knocking down the clathrin heavy chain that M2 uptake upon agonist stimulation requires clathrin. The expression of various dominant-negative dynamin-2 mutants and the use of chemical inhibitors of dynamin function revealed that dynamin expression and membrane localization as such appear to be necessary for M2 endocytosis, whereas dynamin GTPase activity is not required for this process. Based on the data from the present and from previous studies, we propose that M2 endocytosis takes place by means of an atypical clathrin-mediated pathway that may involve a specific subset of clathrin-coated pits/vesicles.

  20. FLOWCHART; a computer program for plotting flowcharts

    Science.gov (United States)

    Bender, Bernice

    1982-01-01

    The computer program FLOWCHART can be used to very quickly and easily produce flowcharts of high quality for publication. FLOWCHART centers each element or block of text that it processes on one of a set of (imaginary) vertical lines. It can enclose a text block in a rectangle, circle or other selected figure. It can draw a 'line connecting the midpoint of any side of any figure with the midpoint of any side of any other figure and insert an arrow pointing in the direction of flow. It can write 'yes' or 'no' next to the line joining two figures. FLOWCHART creates flowcharts using some basic plotting subroutine* which permit plots to be generated interactively and inspected on a Tektronix compatible graphics screen or plotted in a deferred mode on a Houston Instruments 42' pen plotter. The size of the plot, character set and character height in inches are inputs to the program. Plots generated using the pen plotter can be up to 42' high--the larger size plots being directly usable as visual aids in a talk. FLOWCHART centers each block of text on an imaginary column line. (The number of columns and column width are specified as input.) The midpoint of the longest line of text within the block is defined to be the center of the block and is placed on the column line. The spacing of individual words within the block is not altered when the block is positioned. The program writes the first block of text in a designated column and continues placing each subsequent block below the previous block in the same column. A block of text may be placed in a different column by specifying the number of the column and an earlier block of text with which the new block is to be aligned. If block zero is given as the earlier block, the new text is placed in the new column continuing down the page below the previous block. Optionally a column and number of inches from the top of the page may be given for positioning the next block of text. The program will normally draw one of five

  1. Crop residue decomposition in Minnesota biochar amended plots

    Science.gov (United States)

    Weyers, S. L.; Spokas, K. A.

    2014-02-01

    Impacts of biochar application at laboratory scales are routinely studied, but impacts of biochar application on decomposition of crop residues at field scales have not been widely addressed. The priming or hindrance of crop residue decomposition could have a cascading impact on soil processes, particularly those influencing nutrient availability. Our objectives were to evaluate biochar effects on field decomposition of crop residue, using plots that were amended with biochars made from different feedstocks and pyrolysis platforms prior to the start of this study. Litterbags containing wheat straw material were buried below the soil surface in a continuous-corn cropped field in plots that had received one of seven different biochar amendments or a non-charred wood pellet amendment 2.5 yr prior to start of this study. Litterbags were collected over the course of 14 weeks. Microbial biomass was assessed in treatment plots the previous fall. Though first-order decomposition rate constants were positively correlated to microbial biomass, neither parameter was statistically affected by biochar or wood-pellet treatments. The findings indicated only a residual of potentially positive and negative initial impacts of biochars on residue decomposition, which fit in line with established feedstock and pyrolysis influences. Though no significant impacts were observed with field-weathered biochars, effective soil management may yet have to account for repeat applications of biochar.

  2. Carboxyl- and amino-functionalized polystyrene nanoparticles differentially affect the polarization profile of M1 and M2 macrophage subsets.

    Science.gov (United States)

    Fuchs, Ann-Kathrin; Syrovets, Tatiana; Haas, Karina A; Loos, Cornelia; Musyanovych, Anna; Mailänder, Volker; Landfester, Katharina; Simmet, Thomas

    2016-04-01

    Macrophages are key regulators of innate and adaptive immune responses. Exposure to microenvironmental stimuli determines their polarization into proinflammatory M1 and anti-inflammatory M2 macrophages. M1 exhibit high expression of proinflammatory TNF-α and IL-1β, and M2 promote tissue repair, but likewise support tumor growth and cause immune suppression by expressing IL-10. Thus, the M1/M2 balance critically determines tissue homeostasis. By using carboxyl- (PS-COOH) and amino-functionalized (PS-NH2) polystyrene nanoparticles, the effects of surface decoration on the polarization of human macrophages were investigated. The nanoparticles did not compromise macrophage viability nor did they affect the expression of the M1 markers CD86, NOS2, TNF-α, and IL-1β. By contrast, in M2, both nanoparticles impaired expression of scavenger receptor CD163 and CD200R, and the release of IL-10. PS-NH2 also inhibited phagocytosis of Escherichia coli by both, M1 and M2. PS-COOH did not impair phagocytosis by M2, but increased protein mass in M1 and M2, TGF-β1 release by M1, and ATP levels in M2. Thus, nanoparticles skew the M2 macrophage polarization without affecting M1 markers. Given the critical role of the M1 and M2 polarization for the immunological balance in patients with cancer or chronic inflammation, functionalized nanoparticles might serve as tools for reprogramming the M1/M2 polarization.

  3. Master plot analysis of microcracking in graphite/epoxy and graphite/PEEK laminates

    Science.gov (United States)

    Nairn, John A.; Hu, Shoufeng; Bark, Jong Song

    1993-01-01

    We used a variational stress analysis and an energy release rate failure criterion to construct a master plot analysis of matrix microcracking. In the master plot, the results for all laminates of a single material are predicted to fall on a single line whose slope gives the microcracking toughness of the material. Experimental results from 18 different layups of AS4/3501-6 laminates show that the master plot analysis can explain all observations. In particular, it can explain the differences between microcracking of central 90 deg plies and of free-surface 90 deg plies. Experimental results from two different AS4/PEEK laminates tested at different temperatures can be explained by a modified master plot that accounts for changes in the residual thermal stresses. Finally, we constructed similar master plot analyses for previous literature microcracking models. All microcracking theories that ignore the thickness dependence of the stresses gave poor results.

  4. PetroPlot: A plotting and data management tool set for Microsoft Excel

    Science.gov (United States)

    Su, Yongjun; Langmuir, Charles H.; Asimow, Paul D.

    2003-03-01

    PetroPlot is a 4000-line software code written in Visual Basic for the spreadsheet program Excel that automates plotting and data management tasks for large amount of data. The major plotting functions include: automation of large numbers of multiseries XY plots; normalized diagrams (e.g., spider diagrams); replotting of any complex formatted diagram with multiple series for any other axis parameters; addition of customized labels for individual data points; and labeling flexible log scale axes. Other functions include: assignment of groups for samples based on multiple customized criteria; removal of nonnumeric values; calculation of averages/standard deviations; calculation of correlation matrices; deletion of nonconsecutive rows; and compilation of multiple rows of data for a single sample to single rows appropriate for plotting. A cubic spline function permits curve fitting to complex time series, and comparison of data to the fits. For users of Excel, PetroPlot increases efficiency of data manipulation and visualization by orders of magnitude and allows exploration of large data sets that would not be possible making plots individually. The source codes are open to all users.

  5. Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer model.

    Directory of Open Access Journals (Sweden)

    Yi-Rang Na

    Full Text Available Tumor cells are often associated with abundant macrophages that resemble the alternatively activated M2 subset. Tumor-associated macrophages (TAMs inhibit anti-tumor immune responses and promote metastasis. Cyclooxygenase-2 (COX-2 inhibition is known to prevent breast cancer metastasis. This study hypothesized that COX-2 inhibition affects TAM characteristics potentially relevant to tumor cell metastasis. We found that the specific COX-2 inhibitor, etodolac, inhibited human M2 macrophage differentiation, as determined by decreased CD14 and CD163 expressions and increased TNFα production. Several key metastasis-related mediators, such as vascular endothelial growth factor-A, vascular endothelial growth factor-C, and matrix metalloproteinase-9, were inhibited in the presence of etodolac as compared to untreated M2 macrophages. Murine bone marrow derived M2 macrophages also showed enhanced surface MHCII IA/IE and CD80, CD86 expressions together with enhanced TNFα expressions with etodolac treatment during differentiation. Using a BALB/c breast cancer model, we found that etodolac significantly reduced lung metastasis, possibly due to macrophages expressing increased IA/IE and TNFα, but decreased M2 macrophage-related genes expressions (Ym1, TGFβ. In conclusion, COX-2 inhibition caused loss of the M2 macrophage characteristics of TAMs and may assist prevention of breast cancer metastasis.

  6. Realtime multi-plot graphics system

    Science.gov (United States)

    Shipkowski, Michael S.

    1990-01-01

    The increased complexity of test operations and customer requirements at Langley Research Center's National Transonic Facility (NTF) surpassed the capabilities of the initial realtime graphics system. The analysis of existing hardware and software and the enhancements made to develop a new realtime graphics system are described. The result of this effort is a cost effective system, based on hardware already in place, that support high speed, high resolution, generation and display of multiple realtime plots. The enhanced graphics system (EGS) meets the current and foreseeable future realtime graphics requirements of the NTF. While this system was developed to support wind tunnel operations, the overall design and capability of the system is applicable to other realtime data acquisition systems that have realtime plot requirements.

  7. External Use of TOPCAT's Plotting Library

    CERN Document Server

    Taylor, M B

    2014-01-01

    The table analysis application TOPCAT uses a custom Java plotting library for highly configurable high-performance interactive or exported visualisations in two and three dimensions. We present here a variety of ways for end users or application developers to make use of this library outside of the TOPCAT application: via the command-line suite STILTS or its Jython variant JyStilts, via a traditional Java API, or by programmatically assigning values to a set of parameters in java code or using some form of inter-process communication. The library has been built with large datasets in mind; interactive plots scale well up to several million points, and static output to standard graphics formats is possible for unlimited sized input data.

  8. Convex Arrhenius plots and their interpretation

    Science.gov (United States)

    Truhlar, Donald G.; Kohen, Amnon

    2001-01-01

    This paper draws attention to selected experiments on enzyme-catalyzed reactions that show convex Arrhenius plots, which are very rare, and points out that Tolman's interpretation of the activation energy places a fundamental model-independent constraint on any detailed explanation of these reactions. The analysis presented here shows that in such systems, the rate coefficient as a function of energy is not just increasing more slowly than expected, it is actually decreasing. This interpretation of the data provides a constraint on proposed microscopic models, i.e., it requires that any successful model of a reaction with a convex Arrhenius plot should be consistent with the microcanonical rate coefficient being a decreasing function of energy. The implications and limitations of this analysis to interpreting enzyme mechanisms are discussed. This model-independent conclusion has broad applicability to all fields of kinetics, and we also draw attention to an analogy with diffusion in metastable fluids and glasses. PMID:11158559

  9. The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation.

    Science.gov (United States)

    Siegel, Andrea M; Herskowitz, Jeremy H; Speck, Samuel H

    2008-04-01

    Murine gammaherpesvirus 68 (MHV68) establishes long-term latency in memory B cells similar to the human gammaherpesvirus Epstein Barr Virus (EBV). EBV encodes an interleukin-10 (IL-10) homolog and modulates cellular IL-10 expression; however, the role of IL-10 in the establishment and/or maintenance of chronic EBV infection remains unclear. Notably, MHV68 does not encode an IL-10 homolog, but virus infection has been shown to result in elevated serum IL-10 levels in wild-type mice, and IL-10 deficiency results in decreased establishment of virus latency. Here we show that a unique MHV68 latency-associated gene product, the M2 protein, is required for the elevated serum IL-10 levels observed at 2 weeks post-infection. Furthermore, M2 protein expression in primary murine B cells drives high level IL-10 expression along with increased secretion of IL-2, IL-6, and MIP-1alpha. M2 expression was also shown to significantly augment LPS driven survival and proliferation of primary murine B cells. The latter was dependent on IL-10 expression as demonstrated by the failure of IL10-/- B cells to proliferate in response to M2 protein expression and rescue of M2-associated proliferation by addition of recombinant murine IL-10. M2 protein expression in primary B cells also led to upregulated surface expression of the high affinity IL-2 receptor (CD25) and the activation marker GL7, along with down-regulated surface expression of B220, MHC II, and sIgD. The cells retained CD19 and sIgG expression, suggesting differentiation to a pre-plasma memory B cell phenotype. These observations are consistent with previous analyses of M2-null MHV68 mutants that have suggested a role for the M2 protein in expansion and differentiation of MHV68 latently infected B cells-perhaps facilitating the establishment of virus latency in memory B cells. Thus, while the M2 protein is unique to MHV68, analysis of M2 function has revealed an important role for IL-10 in MHV68 pathogenesis-identifying a

  10. The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation.

    Directory of Open Access Journals (Sweden)

    Andrea M Siegel

    2008-04-01

    Full Text Available Murine gammaherpesvirus 68 (MHV68 establishes long-term latency in memory B cells similar to the human gammaherpesvirus Epstein Barr Virus (EBV. EBV encodes an interleukin-10 (IL-10 homolog and modulates cellular IL-10 expression; however, the role of IL-10 in the establishment and/or maintenance of chronic EBV infection remains unclear. Notably, MHV68 does not encode an IL-10 homolog, but virus infection has been shown to result in elevated serum IL-10 levels in wild-type mice, and IL-10 deficiency results in decreased establishment of virus latency. Here we show that a unique MHV68 latency-associated gene product, the M2 protein, is required for the elevated serum IL-10 levels observed at 2 weeks post-infection. Furthermore, M2 protein expression in primary murine B cells drives high level IL-10 expression along with increased secretion of IL-2, IL-6, and MIP-1alpha. M2 expression was also shown to significantly augment LPS driven survival and proliferation of primary murine B cells. The latter was dependent on IL-10 expression as demonstrated by the failure of IL10-/- B cells to proliferate in response to M2 protein expression and rescue of M2-associated proliferation by addition of recombinant murine IL-10. M2 protein expression in primary B cells also led to upregulated surface expression of the high affinity IL-2 receptor (CD25 and the activation marker GL7, along with down-regulated surface expression of B220, MHC II, and sIgD. The cells retained CD19 and sIgG expression, suggesting differentiation to a pre-plasma memory B cell phenotype. These observations are consistent with previous analyses of M2-null MHV68 mutants that have suggested a role for the M2 protein in expansion and differentiation of MHV68 latently infected B cells-perhaps facilitating the establishment of virus latency in memory B cells. Thus, while the M2 protein is unique to MHV68, analysis of M2 function has revealed an important role for IL-10 in MHV68 pathogenesis

  11. A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction

    DEFF Research Database (Denmark)

    Burnett, A. K.; Russell, N. H.; Hills, R. K.

    2015-01-01

    remission rate (73% vs 75%; odds ratio, 1.07 [0.83-1.39]; P = .6) or in any recognized subgroup. The 60-day mortality was increased in the 90 mg/m(2) arm (10% vs 5% (hazard ratio [HR] 1.98 [1.30-3.02]; P = .001), which resulted in no difference in overall 2-year survival (59% vs 60%; HR, 1.16 [0.95-1.43]; P...... recommended as a standard of care. However, 60 mg/m(2) is widely used and has never been directly compared with 90 mg/m(2). As part of the UK National Cancer Research Institute (NCRI) AML17 trial, 1206 adults with untreated AML or high-risk myelodysplastic syndrome, mostly younger than 60 years of age, were...... randomized to a first-induction course of chemotherapy, which delivered either 90 mg/m(2) or 60 mg/m(2) on days 1, 3, and 5 combined with cytosine arabinoside. All patients then received a second course that included daunorubicin 50 mg/m(2) on days 1, 3, and 5. There was no overall difference in complete...

  12. Extended quantification of the generalized recurrence plot

    Science.gov (United States)

    Riedl, Maik; Marwan, Norbert; Kurths, Jürgen

    2016-04-01

    The generalized recurrence plot is a modern tool for quantification of complex spatial patterns. Its application spans the analysis of trabecular bone structures, Turing structures, turbulent spatial plankton patterns, and fractals. But, it is also successfully applied to the description of spatio-temporal dynamics and the detection of regime shifts, such as in the complex Ginzburg-Landau- equation. The recurrence plot based determinism is a central measure in this framework quantifying the level of regularities in temporal and spatial structures. We extend this measure for the generalized recurrence plot considering additional operations of symmetry than the simple translation. It is tested not only on two-dimensional regular patterns and noise but also on complex spatial patterns reconstructing the parameter space of the complex Ginzburg-Landau-equation. The extended version of the determinism resulted in values which are consistent to the original recurrence plot approach. Furthermore, the proposed method allows a split of the determinism into parts which based on laminar and non-laminar regions of the two-dimensional pattern of the complex Ginzburg-Landau-equation. A comparison of these parts with a standard method of image classification, the co-occurrence matrix approach, shows differences especially in the description of patterns associated with turbulence. In that case, it seems that the extended version of the determinism allows a distinction of phase turbulence and defect turbulence by means of their spatial patterns. This ability of the proposed method promise new insights in other systems with turbulent dynamics coming from climatology, biology, ecology, and social sciences, for example.

  13. Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptors.

    Science.gov (United States)

    Vegesna, Anil K; Braverman, Alan S; Miller, Larry S; Tallarida, Ronald J; Tiwana, Mansoor I; Khayyam, Umar; Ruggieri, Michael R

    2010-04-01

    To compare the gastroesophageal junction of the human with the pig, M(2) and M(3) receptor densities and the potencies of M(2) and M(3) muscarinic receptor subtype selective antagonists were determined in gastric clasp and sling smooth muscle fibers. Total muscarinic and M(2) receptors are higher in pig than human clasp and sling fibers. M(3) receptors are higher in human compared with pig sling fibers but lower in human compared with pig clasp fibers. Clasp fibers have fewer M(3) receptors than sling fibers in both humans and pigs. Similar to human clasp fibers, pig clasp fibers contract significantly less than pig sling fibers. Analysis of the methoctramine Schild plot suggests that M(2) receptors are involved in mediating contraction in pig clasp and sling fibers. Darifenacin potency suggests that M(3) receptors mediate contraction in pig sling fibers and that M(2) and M(3) receptors mediate contraction in pig clasp fibers. Taken together, the data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp and sling fibers similar to human clasp and sling fibers.

  14. M2 Polarization of Human Macrophages Favors Survival of the Intracellular Pathogen Chlamydia pneumoniae.

    Directory of Open Access Journals (Sweden)

    Tanja Buchacher

    Full Text Available Intracellular pathogens have developed various strategies to escape immunity to enable their survival in host cells, and many bacterial pathogens preferentially reside inside macrophages, using diverse mechanisms to penetrate their defenses and to exploit their high degree of metabolic diversity and plasticity. Here, we characterized the interactions of the intracellular pathogen Chlamydia pneumoniae with polarized human macrophages. Primary human monocytes were pre-differentiated with granulocyte macrophage colony-stimulating factor or macrophage colony-stimulating factor for 7 days to yield M1-like and M2-like macrophages, which were further treated with interferon-γ and lipopolysaccharide or with interleukin-4 for 48 h to obtain fully polarized M1 and M2 macrophages. M1 and M2 cells exhibited distinct morphology with round or spindle-shaped appearance for M1 and M2, respectively, distinct surface marker profiles, as well as different cytokine and chemokine secretion. Macrophage polarization did not influence uptake of C. pneumoniae, since comparable copy numbers of chlamydial DNA were detected in M1 and M2 at 6 h post infection, but an increase in chlamydial DNA over time indicating proliferation was only observed in M2. Accordingly, 72±5% of M2 vs. 48±7% of M1 stained positive for chlamydial lipopolysaccharide, with large perinuclear inclusions in M2 and less clearly bordered inclusions for M1. Viable C. pneumoniae was present in lysates from M2, but not from M1 macrophages. The ability of M1 to restrict chlamydial replication was not observed in M1-like macrophages, since chlamydial load showed an equal increase over time for M1-like and M2-like macrophages. Our findings support the importance of macrophage polarization for the control of intracellular infection, and show that M2 are the preferred survival niche for C. pneumoniae. M1 did not allow for chlamydial proliferation, but failed to completely eliminate chlamydial infection

  15. AvoPlot: An extensible scientific plotting tool based on matplotlib

    Directory of Open Access Journals (Sweden)

    Nial Peters

    2014-02-01

    Full Text Available AvoPlot is a simple-to-use graphical plotting program written in Python and making extensive use of the matplotlib plotting library. It can be found at http://code.google.com/p/avoplot/. In addition to providing a user-friendly interface to the powerful capabilities of the matplotlib library, it also offers users the possibility of extending its functionality by creating plug-ins. These can import specific types of data into the interface and also provide new tools for manipulating them. In this respect, AvoPlot is a convenient platform for researchers to build their own data analysis tools on top of, as well as being a useful standalone program.

  16. 9 CFR 108.3 - Preparation of plot plans.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Preparation of plot plans. 108.3... LICENSED ESTABLISHMENTS § 108.3 Preparation of plot plans. Plot plans shall show all of the buildings on a... on the plot plan the use of immediate adjacent properties such as, residential area, pasture,...

  17. M$^2$I Communication: From Theoretical Modeling to Practical Design

    CERN Document Server

    Guo, Hongzhi

    2015-01-01

    Wireless communications in complex environments are constrained by lossy media and complicated structures. Magnetic Induction (MI) has been proved to be an efficient solution to extend the communication range. Due to the small coil antenna's physical limitation, however, MI's communication range is still very limited. To this end, Metamaterial-enhanced Magnetic Induction (M$^2$I) communication has been proposed and the theoretical results suggest that it can significantly increase the communication performance, namely, data rate and communication range. Nevertheless, currently, the real implementation of M$^2$I is still a challenge and there is no guideline on design and fabrication of spherical metamaterial. In this paper, we propose a practical design by using a spherical coil array to realize M$^2$I and we prove that it can achieve negative permeability and there exists a resonance condition where the radiated magnetic field can be significantly amplified. The radiation and communication performance are ev...

  18. Split-Plot Designs with Mirror Image Pairs as Subplots

    DEFF Research Database (Denmark)

    Tyssedal, John; Kulahci, Murat; Bisgaard, Soren

    2011-01-01

    In this article we investigate two-level split-plot designs where the sub-plots consist of only two mirror image trials. Assuming third and higher order interactions negligible, we show that these designs divide the estimated effects into two orthogonal sub-spaces, separating sub-plot main effects...... and sub-plot by whole-plot interactions from the rest. Further we show how to construct split-plot designs of projectivity P≥3. We also introduce a new class of split-plot designs with mirror image pairs constructed from non-geometric Plackett–Burman designs. The design properties of such designs are very...

  19. Field Plot Techniques for Black Sigatoka Evaluation in East African Highland Bananas

    Directory of Open Access Journals (Sweden)

    Okoro, JU.

    1997-01-01

    Full Text Available Number of plants per experimental unit and number of replications for the efficient and precise assessment of black sigatoka leaf spot disease caused by Mycosphaerella fijiensis in East African Highland bananas were determined. Two representative cultivars were used. Host response to black sigatoka infection was measured by recording the youngest leaf with necrotic spots. The number of plants per experimental unit was determined, using the methods of maximum curvature and comparison of variances, while the number of replications was estimated by Hatheway's method. The optimum experimental plot size was 3 plants (18 m2 for the beer banana cultivar 'Igitsiri', and 30 plants (180 m2 for the cooking banana cultivar 'Igisahira Gisanzwe', using the comparison of variances method. However, the optimum plot size was 15 plants (90 m2 for both cultivars using the method of maximum curvature. The latter statistical method was preferred because of the low precision of the estimates in the former method. Unreplicated trials with plots of 15 plants could be adequate to assess black sigatoka response in East African bananas if uniform disease pressure exists.

  20. M2-F1 on lakebed with pilot Milt Thompson

    Science.gov (United States)

    1963-01-01

    NASA Flight Research Pilot Milt Thompson, shown here on the lakebed with the M2-F1 lifting body, was an early backer of R. Dale Reed's lifting-body proposal. He urged Flight Research Center director Paul Bikle to approve the M2-F1's construction. Thompson also made the first glide flights in both the M2-F1 and its successor, the heavyweight M2-F2. The wingless, lifting body aircraft design was initially conceived as a means of landing an aircraft horizontally after atmospheric reentry. The absence of wings would make the extreme heat of re-entry less damaging to the vehicle. In 1962, NASA Flight Research Center (later Dryden Flight Research Center, Edwards, CA) management approved a program to build a lightweight, unpowered lifting body as a prototype to flight test the wingless concept. It would look like a 'flying bathtub,' and was designated the M2-F1, the 'M' referring to 'manned' and 'F' referring to 'flight' version. It featured a plywood shell placed over a tubular steel frame crafted at Dryden. Construction was completed in 1963. The first flight tests of the M2-F1 were over Rogers Dry Lake at the end of a tow rope attached to a hopped-up Pontiac convertible driven at speeds up to about 120 mph. This vehicle needed to be able to tow the M2-F1 on the Rogers Dry Lakebed adjacent to NASA's Flight Research Center (FRC) at a minimum speed of 100 miles per hour. To do that, it had to handle the 400-pound pull of the M2-F1. Walter 'Whitey' Whiteside, who was a retired Air Force maintenance officer working in the FRC's Flight Operations Division, was a dirt-bike rider and hot-rodder. Together with Boyden 'Bud' Bearce in the Procurement and Supply Branch of the FRC, Whitey acquired a Pontiac Catalina convertible with the largest engine available. He took the car to Bill Straup's renowned hot-rod shop near Long Beach for modification. With a special gearbox and racing slicks, the Pontiac could tow the 1,000-pound M2-F1 110 miles per hour in 30 seconds. It proved

  1. Optimal plot design in a multipurpose forest inventory

    Directory of Open Access Journals (Sweden)

    Helena M. Henttonen

    2015-12-01

    Full Text Available Background: We explore the factors affecting the optimal plot design (size and type as well as the subsample tree selection strategies within a plot and their relative importance in defining the optimal plot design in amultipurpose forest inventory. The factors include time used to lay out the plot and to make the tree measurements within the plot, the between-plot variation of each of the variables of interest in the area, and the measurement and model errors for the different variables. Methods: We simulate different plot types and sizes and subsample tree selection strategies on measuredtest areas from North Lapland. The plot types used are fixed-radius, concentric and relascope plots. Weselect the optimal type and size first at plot level using a cost-plus-loss approach and then at cluster level byminimizing the weighted standard error with fixed budget. Results: As relascope plots are very efficient at the plot level for volume and basal area, and fixed-radius plots for stems per ha, the optimal plot type strongly depends on the relative importance of these variables. The concentric plot seems to be a good compromise between these two in many cases. The subsample tree selection strategy was more important in selecting optimal plot than many other factors. In cluster level, the most important factor is the transfer time between plots. Conclusions: While the optimal radius of plots and other parameters were sensitive to the measurement times and other cost factors, the concentric plot type was optimal in almost all studied cases. Subsample tree measurement strategies need further studies, as they were an important cost factor. However, their importance to the precision was not as clear. Keywords: Sample, Plot, Forest inventory, Measurement, Cost, Loss

  2. M2 macrophages induce EMT through the TGF-β/Smad2 signaling pathway.

    Science.gov (United States)

    Zhu, Liangying; Fu, Xiao; Chen, Xiang; Han, Xiaodong; Dong, Ping

    2017-09-01

    IPF is characterized by fibroblast accumulation, collagen deposition, and ECM remodeling, with myofibroblasts believed to be the effector cell type. Myofibroblasts develop due to EMT of lung alveolar epithelial cells, which can be induced by TGF-β. M2 macrophages, a macrophage subpopulation, secrete large amounts of TGF-β. To clarify the relationship between IPF, EMT, TGF-β, and M2 macrophages, a bleomycin-induced pulmonary fibrosis mouse model was used. Seventeen days after mice were treated with bleomycin, the successful establishment of a pulmonary fibrosis model was confirmed by HE stain and Masson's trichrome stain. We found evidence in support of EMT, such as elevated protein levels of α-SMA in lung tissue and decreased levels of E-cadherin and CK-18. Additionally, increased TGF-β levels and TGF-β/Smad2 signaling activation was observed. Macrophages were recruited to pulmonary alveoli. Alveolar macrophages were phenotyped and identified as M2 macrophages, with up-regulated CD206 on the cell surfaces. For in vitro studies, we treated RAW 264.7 cells with IL-4 for 24 h, and the cells were then utilized as M2 macrophages. TGF-β levels increased significantly in the culture supernatant. Forty-eight hours after lung epithelial cells (MLE-12) were co-cultured with the M2 macrophages, the expression of α-SMA increased, and E-cadherin and CK-18 decreased. When a TGF-β receptor inhibitor, LY2109761 was used, the EMT induced by M2 macrophages was blocked. In conclusion, we demonstrated that M2 macrophages induce EMT through the TGF-β/Smad2 signaling pathway. © 2017 International Federation for Cell Biology.

  3. M2磁带机挑战极限

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    日前安百特(Exabyte)公司宣布,其OEM合作伙伴Cybernetics在对Mammoth-2(M2)磁带机的性能和可靠性测试中取得了创记录的结果,从而加快了M2的商业交付计划。M2磁带机以部门级价格提供了企业级的性能,其容量增加50%,达到60GB,性能提高一倍,传输率达到12MB/s,可在一小时内备份43GB数据(未压缩)。Cybernetics利用该公司为了故意“破坏”磁带机而创建的定制软件对M2进行了测试,包括读/写能力测试、

  4. Dimeric Complexes of Tryptophan with M2+ Metal Ions

    NARCIS (Netherlands)

    Dunbar, R. C.; Steill, J. D.; Polfer, N. C.; Oomens, J.

    2009-01-01

    IRMPD spectroscopy using the FELIX free electron laser and a Fourier transform ICR mass spectrometer was used to characterize the structures of electrosprayed dimer complexes M(2+)Trp(2) of tryptophan with a series of eight doubly charged metal ions, including alkaline earths Ca, Sr, and Ba, and tra

  5. M2e-Based Universal Influenza A Vaccines

    Directory of Open Access Journals (Sweden)

    Lei Deng

    2015-02-01

    Full Text Available The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease. However, licensed influenza vaccines offer protection against antigenically matching viruses, and the composition of these vaccines needs to be updated nearly every year. Vaccines that target conserved epitopes of influenza viruses would in principle not require such updating and would probably have a considerable positive impact on global human health in case of a pandemic outbreak. The extracellular domain of Matrix 2 (M2e protein is an evolutionarily conserved region in influenza A viruses and a promising epitope for designing a universal influenza vaccine. Here we review the seminal and recent studies that focused on M2e as a vaccine antigen. We address the mechanism of action and the clinical development of M2e-vaccines. Finally, we try to foresee how M2e-based vaccines could be implemented clinically in the future.

  6. Progress On 58m2 Passive Resonant Ring Laser Gyroscope

    Science.gov (United States)

    Shaw, G. L.; Rotge, J.; Simmons, B. J.

    1986-01-01

    An update of the large area (now 60m2) Passive Resonant Ring Laser Gyro (PRRLG) is given. Some aspects of last year's design have changed; but performance is still predicted to be in the 10-10 earth rate unit (ERU) range. This is of interest for a number of geophysical applications.

  7. Charm Dalitz Plot Analysis Formalism and Results

    CERN Document Server

    Asner, David M

    2004-01-01

    Charm meson decay dynamics have been studied extensively over the last decade. We describe the Dalitz-plot analysis technique which has been applied by many experiments to three-body D0, D+ and Ds decays. We discuss experimental results from Mark II, Mark III, E687, E691, ARGUS, E791, FOCUS, CLEO and BABAR. These studies probe a variety of physics including doubly-Cabibbo suppressed decays, searches for CP violation, the properties of established light mesons and the properties of pipi and Kpi S-wave states.

  8. Prophylactic and therapeutic activity of fully human monoclonal antibodies directed against Influenza A M2 protein

    Directory of Open Access Journals (Sweden)

    Gwerder Myriam

    2009-12-01

    Full Text Available Abstract Influenza virus infection is a prevalent disease in humans. Antibodies against hemagglutinin have been shown to prevent infection and hence hemagglutinin is the major constituent of current vaccines. Antibodies directed against the highly conserved extracellular domain of M2 have also been shown to mediate protection against Influenza A infection in various animal models. Active vaccination is generally considered the best approach to combat viral diseases. However, passive immunization is an attractive alternative, particularly in acutely exposed or immune compromized individuals, young children and the elderly. We recently described a novel method for the rapid isolation of natural human antibodies by mammalian cell display. Here we used this approach to isolate human monoclonal antibodies directed against the highly conserved extracellular domain of the Influenza A M2 protein. The identified antibodies bound M2 peptide with high affinities, recognized native cell-surface expressed M2 and protected mice from a lethal influenza virus challenge. Moreover, therapeutic treatment up to 2 days after infection was effective, suggesting that M2-specific monoclonals have a great potential as immunotherapeutic agents against Influenza infection.

  9. Optimal plot design in a multipurpose forest inventory

    Institute of Scientific and Technical Information of China (English)

    Helena M Henttonen; Annika Kangas

    2016-01-01

    Background:We explore the factors affecting the optimal plot design (size and type as well as the subsample tree selection strategies within a plot) and their relative importance in defining the optimal plot design in amultipurpose forest inventory. The factors include time used to lay out the plot and to make the tree measurements within the plot, the between-plot variation of each of the variables of interest in the area, and the measurement and model errors for the different variables. Methods:We simulate different plot types and sizes and subsample tree selection strategies on measuredtest areas from North Lapland. The plot types used are fixed-radius, concentric and relascope plots. Weselect the optimal type and size first at plot level using a cost-plus-loss approach and then at cluster level byminimizing the weighted standard error with fixed budget. Results:As relascope plots are very efficient at the plot level for volume and basal area, and fixed-radius plots for stems per ha, the optimal plot type strongly depends on the relative importance of these variables. The concentric plot seems to be a good compromise between these two in many cases. The subsample tree selection strategy was more important in selecting optimal plot than many other factors. In cluster level, the most important factor is the transfer time between plots. Conclusions:While the optimal radius of plots and other parameters were sensitive to the measurement times and other cost factors, the concentric plot type was optimal in almost al studied cases. Subsample tree measurement strategies need further studies, as they were an important cost factor. However, their importance to the precision was not as clear.

  10. Effect of vegetal cover on runoff and soil erosion under light intensity events. Rainfall simulation over USLE plots.

    Science.gov (United States)

    Marques, María José; Bienes, Ramón; Jiménez, Luis; Pérez-Rodríguez, Raquel

    2007-05-25

    The erosive power of frequent light rainfalls is studied in this paper. Field experiments of simulated rainfall (Intensity, 21 mm h(-1) and kinetic energy, 13.5 J m(-2) mm(-1)) were conducted over 8 bounded USLE plots (80 m(2) each) with a slope of 10%. In 4 plots the soil was almost bare (<4% vegetation cover); the other 4 plots had almost full cover with natural vegetation in one year. Runoff and sediment yield was recorded. The results revealed the efficiency of vegetation cover reducing runoff and sediments. Runoff and sediments were negligible in covered plots. Therefore, in bare plots, although sediment yield was generally low, averaging 74+/-43 kg ha(-1), the mean of runoff achieved a coefficient of 35%, this magnitude has to be taken into consideration in this region verging on aridity. Rains around 13.5 J m(-2) mm(-1) of kinetic energy are quite frequent in the study area (34% of recorded rains en 12 years). If we would consider the usual lower limits from the literature, we would be ignoring an important percent of natural rainfall episodes.

  11. Internal steel structure of M2-F1

    Science.gov (United States)

    1963-01-01

    The internal steel structure for the M2-F1 was built at the Flight Research Center (predecessor of the Dryden Flight Research Center, Edwards, CA) in a section of the calibration hangar dubbed 'Wright Bicycle Shop.' Visible are the stick, rudder pedals, and ejection seat. The external wooden shell was attached to the steel structure. The wingless, lifting body aircraft design was initially conceived as a means of landing an aircraft horizontally after atmospheric reentry. The absence of wings would make the extreme heat of re-entry less damaging to the vehicle. In 1962, Dryden management approved a program to build a lightweight, unpowered lifting body as a prototype to flight test the wingless concept. It would look like a 'flying bathtub,' and was designated the M2-F1, the 'M' referring to 'manned' and 'F' referring to 'flight' version. It featured a plywood shell placed over a tubular steel frame crafted at Dryden. Construction was completed in 1963. The first flight tests of the M2-F1 were over Rogers Dry Lake at the end of a tow rope attached to a hopped-up Pontiac convertible driven at speeds up to about 120 mph. This vehicle needed to be able to tow the M2-F1 on the Rogers Dry Lakebed adjacent to NASA's Flight Research Center (FRC) at a minimum speed of 100 miles per hour. To do that, it had to handle the 400-pound pull of the M2-F1. Walter 'Whitey' Whiteside, who was a retired Air Force maintenance officer working in the FRC's Flight Operations Division, was a dirt-bike rider and hot-rodder. Together with Boyden 'Bud' Bearce in the Procurement and Supply Branch of the FRC, Whitey acquired a Pontiac Catalina convertible with the largest engine available. He took the car to Bill Straup's renowned hot-rod shop near Long Beach for modification. With a special gearbox and racing slicks, the Pontiac could tow the 1,000-pound M2-F1 110 miles per hour in 30 seconds. It proved adequate for the roughly 400 car tows that got the M2-F1 airborne to prove it could fly

  12. Construction of an experimental plot seeder of wheat planting and compare it by imported one

    Directory of Open Access Journals (Sweden)

    I Eskandari

    2016-09-01

    spinner can be equipped with a 4 or 6 outlet delivery head, depending on row spacing. The planter is fitted with hoe openers. Alternatively, spear-point openers have sometimes been used under conventional tillage systems. Seeding depth control was achieved by an adjustment screw handle. The plot seeder is being moved by a 9.6 kW engine, and has been successfully used in applications. Field experiment established by using 4 plot length (2, 3, 4 and 6 with 4 replication by the constructed plot seeder and imported plot seeder. Crop measurements were planted height, spike m-2, seeds/spike, Thousand kernel weight, Biological and grain yield, harvest index and drill measurements were seeding depth, uniformity of row spacing in action, seed counter performance, power requirement, slippage evenly of rows after planting. Results and Discussion Results showed that there were significant differences between the plant emergences. The emergencies were higher in plots, which planted by the new plot seeder. The differences between seed distribution of openers were insignificant, but the variances of new plot seeder and imported plot seeder were 0.267 and 1.05 respectively. Mean planting depth of plots planted by the Wintersteiger plot seeder was 0.8 cm shallower than the adjusted planting depth while mean planting depth in plots planted by constructing machine had only 0.01 cm variation. Results of variance analysis revealed that effect of treatments on wheat grain yield and yield components was significant. So that, highest grain yield (4216 kgha-1, biological yield (8704 kgha-1, number of spikes per square meter (649spike, obtained from a plot which planted by constructed plot seeder. Increasing yield of treatments which planted by constructed plot seeder might be because of increasing the number of spikes per square meter in those treatments. The mean of spike per square meter in plots of new planter was 691 spikes which were116 spike more than plots planted by imported plot seeder

  13. Construction of an experimental plot seeder of wheat planting and compare it by imported one

    Directory of Open Access Journals (Sweden)

    I Eskandari

    2016-09-01

    spinner can be equipped with a 4 or 6 outlet delivery head, depending on row spacing. The planter is fitted with hoe openers. Alternatively, spear-point openers have sometimes been used under conventional tillage systems. Seeding depth control was achieved by an adjustment screw handle. The plot seeder is being moved by a 9.6 kW engine, and has been successfully used in applications. Field experiment established by using 4 plot length (2, 3, 4 and 6 with 4 replication by the constructed plot seeder and imported plot seeder. Crop measurements were planted height, spike m-2, seeds/spike, Thousand kernel weight, Biological and grain yield, harvest index and drill measurements were seeding depth, uniformity of row spacing in action, seed counter performance, power requirement, slippage evenly of rows after planting. Results and Discussion Results showed that there were significant differences between the plant emergences. The emergencies were higher in plots, which planted by the new plot seeder. The differences between seed distribution of openers were insignificant, but the variances of new plot seeder and imported plot seeder were 0.267 and 1.05 respectively. Mean planting depth of plots planted by the Wintersteiger plot seeder was 0.8 cm shallower than the adjusted planting depth while mean planting depth in plots planted by constructing machine had only 0.01 cm variation. Results of variance analysis revealed that effect of treatments on wheat grain yield and yield components was significant. So that, highest grain yield (4216 kgha-1, biological yield (8704 kgha-1, number of spikes per square meter (649spike, obtained from a plot which planted by constructed plot seeder. Increasing yield of treatments which planted by constructed plot seeder might be because of increasing the number of spikes per square meter in those treatments. The mean of spike per square meter in plots of new planter was 691 spikes which were116 spike more than plots planted by imported plot seeder

  14. Species richness, abundance and phenology of fungal fruit bodies over 21 years in a Swiss forest plot

    NARCIS (Netherlands)

    Straatsma, G.; Ayer, F.; Egli, S.

    2001-01-01

    Fungal fruit bodies were surveyed on a plot area of 1500 m2 from 1975¿99 (excluding 1980¿83) in the fungal reserve La Chaneaz in western Switzerland. Fruit bodies were identified and counted on a weekly basis. Species richness and abundances varied strongly between years. More than 400 species were

  15. Tyrosine 129 of the murine gammaherpesvirus M2 protein is critical for M2 function in vivo.

    Directory of Open Access Journals (Sweden)

    Udaya S Rangaswamy

    Full Text Available A common strategy shared by all known gammaherpesviruses is their ability to establish a latent infection in lymphocytes--predominantly in B cells. In immunocompromised patients, such as transplant recipients or AIDS patients, gammaherpesvirus infections can lead to the development of lymphoproliferative disease and lymphoid malignancies. The human gamma-herpesviruses, EBV and KSHV, encode proteins that are capable of modulating the host immune signaling machinery, thereby subverting host immune responses. Murine gamma-herpesvirus 68 (MHV68 infection of laboratory strains of mice has proven to be useful small-animal model that shares important pathogenic strategies with the human gamma-herpesviruses. The MHV68 M2 protein is known to manipulate B cell signaling and, dependent on route and dose of virus inoculation, plays a role in both the establishment of latency and virus reactivation. M2 contains two tyrosines that are targets for phosphorylation, and have been shown to interact with the B cell signaling machinery. Here we describe in vitro and in vivo studies of M2 mutants which reveals that while both tyrosines Y120 and Y129 are required for M2 induction of IL-10 expression from primary murine B cells in vitro, only Y129 is critical for reactivation from latency and plasma cell differentiation in vivo.

  16. Tyrosine 129 of the murine gammaherpesvirus M2 protein is critical for M2 function in vivo.

    Science.gov (United States)

    Rangaswamy, Udaya S; O'Flaherty, Brigid M; Speck, Samuel H

    2014-01-01

    A common strategy shared by all known gammaherpesviruses is their ability to establish a latent infection in lymphocytes--predominantly in B cells. In immunocompromised patients, such as transplant recipients or AIDS patients, gammaherpesvirus infections can lead to the development of lymphoproliferative disease and lymphoid malignancies. The human gamma-herpesviruses, EBV and KSHV, encode proteins that are capable of modulating the host immune signaling machinery, thereby subverting host immune responses. Murine gamma-herpesvirus 68 (MHV68) infection of laboratory strains of mice has proven to be useful small-animal model that shares important pathogenic strategies with the human gamma-herpesviruses. The MHV68 M2 protein is known to manipulate B cell signaling and, dependent on route and dose of virus inoculation, plays a role in both the establishment of latency and virus reactivation. M2 contains two tyrosines that are targets for phosphorylation, and have been shown to interact with the B cell signaling machinery. Here we describe in vitro and in vivo studies of M2 mutants which reveals that while both tyrosines Y120 and Y129 are required for M2 induction of IL-10 expression from primary murine B cells in vitro, only Y129 is critical for reactivation from latency and plasma cell differentiation in vivo.

  17. Hypothetical Outcome Plots Outperform Error Bars and Violin Plots for Inferences about Reliability of Variable Ordering.

    Directory of Open Access Journals (Sweden)

    Jessica Hullman

    Full Text Available Many visual depictions of probability distributions, such as error bars, are difficult for users to accurately interpret. We present and study an alternative representation, Hypothetical Outcome Plots (HOPs, that animates a finite set of individual draws. In contrast to the statistical background required to interpret many static representations of distributions, HOPs require relatively little background knowledge to interpret. Instead, HOPs enables viewers to infer properties of the distribution using mental processes like counting and integration. We conducted an experiment comparing HOPs to error bars and violin plots. With HOPs, people made much more accurate judgments about plots of two and three quantities. Accuracy was similar with all three representations for most questions about distributions of a single quantity.

  18. Hypothetical Outcome Plots Outperform Error Bars and Violin Plots for Inferences about Reliability of Variable Ordering

    Science.gov (United States)

    Hullman, Jessica; Resnick, Paul; Adar, Eytan

    2015-01-01

    Many visual depictions of probability distributions, such as error bars, are difficult for users to accurately interpret. We present and study an alternative representation, Hypothetical Outcome Plots (HOPs), that animates a finite set of individual draws. In contrast to the statistical background required to interpret many static representations of distributions, HOPs require relatively little background knowledge to interpret. Instead, HOPs enables viewers to infer properties of the distribution using mental processes like counting and integration. We conducted an experiment comparing HOPs to error bars and violin plots. With HOPs, people made much more accurate judgments about plots of two and three quantities. Accuracy was similar with all three representations for most questions about distributions of a single quantity. PMID:26571487

  19. A Plot Story:The Ransom of Red Chief

    Institute of Scientific and Technical Information of China (English)

    WANG Si-yu

    2015-01-01

    The Ransom of Red Chief is a short story written by O · Henry. Some critics regard it as a plot story but some do not. A typical plot story should focus on the plot:using techniques such as flashback or foreshadowing to unfold the plot and containing exposition, complication, climax, resolution, conclusion to rich the plot. The main characters are presented with internal and ex⁃ternal conflicts as well. In this thesis, a detailed analysis will be presented to prove that this story is really a plot story.

  20. Terrestrial salamander captures in 100 m2 sub-plots two years after the 2003 Clark fire (Willamette National Forest, OR)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Data exist in a Microsoft Access 2003 database, and are the result of fixed-area, time-constrained searches for terrestrial salamanders within and nearby a...

  1. Activation and dynamic network of the M2 muscarinic receptor

    OpenAIRE

    Miao, Yinglong; Nichols, Sara E.; Gasper, Paul M.; Metzger, Vincent T; McCammon, J. Andrew

    2013-01-01

    G-protein-coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. Although significant advances have been made in structural studies of GPCRs, details of their activation mechanism remain unclear. The X-ray crystal structure of the M2 muscarinic receptor, a key GPCR that regulates human heart rate and contractile forces of cardiomyocytes, was determined recently in an inactive antagonist...

  2. Wilson Loops for M2- and M5-brane spaces

    CERN Document Server

    Quijada, Edward

    2015-01-01

    We calculate the quark and anti-quark interaction energy in different positions in spaces generated by $N$ coincident $M2$- and $M5$-branes. We use the Maldacena-Rey-Yee method for calculating this energy as a function of quark-antiquark separation. We obtain the solution for these problems as integrals of the metric elements. For limiting regimes we find simpler solutions for which some potentials exhibit a confinement behavior.

  3. Generalized confidence interval plots using commands or dialogs

    OpenAIRE

    Roger Newson

    2005-01-01

    Confidence intervals may be presented as publication-ready tables or as presentation-ready plots. -eclplot- produces plots of estimates and confidence intervals. It inputs a dataset (or resultsset) with one observation per parameter and variables containing estimates, lower and upper confidence limits, and a fourth variable, against which the confidence intervals are plotted. This resultsset can be used for producing both plots and tables, and may be generated using a spreadsheet or using -st...

  4. When does the mean excess plot look linear?

    CERN Document Server

    Ghosh, Souvik

    2010-01-01

    In risk analysis, the mean excess plot is a commonly used exploratory plotting technique for confirming iid data is consistent with a generalized Pareto assumption for the underlying distribution, since in the presence of such a distribution thresholded data have a mean excess plot that is roughly linear. Does any other class of distributions share this linearity of the plot? Under some extra assumptions, we are able to conclude that only the generalized Pareto family has this property.

  5. Worm plot to diagnose fit in quantile regression

    NARCIS (Netherlands)

    Buuren, S. van

    2007-01-01

    The worm plot is a series of detrended Q-Q plots, split by covariate levels. The worm plot is a diagnostic tool for visualizing how well a statistical model fits the data, for finding locations at which the fit can be improved, and for comparing the fit of different models. This paper shows how the

  6. Worm plot to diagnose fit in quantile regression

    NARCIS (Netherlands)

    Buuren, S. van

    2007-01-01

    The worm plot is a series of detrended Q-Q plots, split by covariate levels. The worm plot is a diagnostic tool for visualizing how well a statistical model fits the data, for finding locations at which the fit can be improved, and for comparing the fit of different models. This paper shows how

  7. Worm plot to diagnose fit in quantile regression

    NARCIS (Netherlands)

    Buuren, S. van

    2007-01-01

    The worm plot is a series of detrended Q-Q plots, split by covariate levels. The worm plot is a diagnostic tool for visualizing how well a statistical model fits the data, for finding locations at which the fit can be improved, and for comparing the fit of different models. This paper shows how the

  8. M2-Branes in N = 3 Harmonic Superspace

    Directory of Open Access Journals (Sweden)

    E. Ivanov

    2010-01-01

    Full Text Available We give a brief account of the recently proposed N = 3 superfield formulation of the N = 6, 3D superconformal theory of Aharony et al (ABJM describing a low-energy limit of the system of multiple M2-branes on the AdS4×S7/Zk background. This formulation is given in harmonic N = 3 superspace and reveals a number of surprising new features. In particular, the sextic scalar potential of ABJM arises at the on-shell component level as the result of eliminating appropriate auxiliary fields, while there is no explicit superpotential at the off-shell superfield level.

  9. M2-branes and AdS/CFT

    CERN Document Server

    Klebanov, Igor R

    2009-01-01

    These notes provide a brief introduction to the ABJM theory, the level k U(N) x U(N) superconformal Chern-Simons matter theory which has been conjectured to describe N coincident M2-branes. We discuss its dual formulation in terms of M-theory on AdS_4 x S^7/Z_k and review some of the evidence in favor of the conjecture. We end with a brief discussion of the important role played by the monopole operators.

  10. Superconformal M2-branes and generalized Jordan triple systems

    CERN Document Server

    Nilsson, Bengt E W

    2008-01-01

    Three-dimensional conformal theories with six supersymmetries and SU(4) R-symmetry describing stacks of M2-branes are here proposed to be related to generalized Jordan triple systems. Writing the four-index structure constants in an appropriate form, the Chern-Simons part of the action immediately suggests a connection to such triple systems. In this note we show that the whole theory with six manifest supersymmetries can be naturally expressed in terms of structure constants of generalized Jordan triple systems. We comment on the associated graded Lie algebra, which corresponds to an extension of the gauge group.

  11. Validity of the t-plot method to assess microporosity in hierarchical micro/mesoporous materials.

    Science.gov (United States)

    Galarneau, Anne; Villemot, François; Rodriguez, Jeremy; Fajula, François; Coasne, Benoit

    2014-11-11

    The t-plot method is a well-known technique which allows determining the micro- and/or mesoporous volumes and the specific surface area of a sample by comparison with a reference adsorption isotherm of a nonporous material having the same surface chemistry. In this paper, the validity of the t-plot method is discussed in the case of hierarchical porous materials exhibiting both micro- and mesoporosities. Different hierarchical zeolites with MCM-41 type ordered mesoporosity are prepared using pseudomorphic transformation. For comparison, we also consider simple mechanical mixtures of microporous and mesoporous materials. We first show an intrinsic failure of the t-plot method; this method does not describe the fact that, for a given surface chemistry and pressure, the thickness of the film adsorbed in micropores or small mesopores (plot method to estimate the micro- and mesoporous volumes of hierarchical samples is then discussed, and an abacus is given to correct the underestimated microporous volume by the t-plot method.

  12. Recurrence plots and chaotic motion around Kerr black hole

    CERN Document Server

    Kopáček, Ondřej; Karas, Vladimír; Stuchlík, Zdeněk; 10.1063/1.3506071

    2010-01-01

    We study the motion of charged test particles around a Kerr black hole immersed in the asymptotically uniform magnetic field, concluding that off-equatorial stable orbits are allowed in this system. Being interested in dynamical properties of these astrophysically relevant orbits we employ rather novel approach based on the analysis of recurrences of the system to the vicinity of its previous states. We use recurrence plots (RPs) as a tool to visualize recurrences of the trajectory in the phase space. Construction of RPs is simple and straightforward regardless of the dimension of the phase space, which is a major advantage of this approach when compared to the "traditional" methods of the numerical analysis of dynamical systems (for instance the visual survey of Poincar\\'{e} surfaces of section, evaluation of the Lyapunov spectra etc.). We show that RPs and their quantitative measures (obtained from recurrence quantification analysis -- RQA) are powerful tools to detect dynamical regime of motion (regular vs...

  13. Modelling runoff at the plot scale taking into account rainfall partitioning by vegetation: application to stemflow of banana (Musa spp. plant

    Directory of Open Access Journals (Sweden)

    Y.-M. Cabidoche

    2009-11-01

    Full Text Available Rainfall partitioning by vegetation modifies the intensity of rainwater reaching the ground, which affects runoff generation. Incident rainfall is intercepted by the plant canopy and then redistributed into throughfall and stemflow. Rainfall intensities at the soil surface are therefore not spatially uniform, generating local variations of runoff production that are disregarded in runoff models. The aim of this paper was to model runoff at the plot scale, accounting for rainfall partitioning by vegetation in the case of plants concentrating rainwater at the plant foot and promoting stemflow. We developed a lumped modelling approach, including a stemflow function that divided the plot into two compartments: one compartment including stemflow and the related water pathways and one compartment for the rest of the plot. This stemflow function was coupled with a production function and a transfer function to simulate a flood hydrograph using the MHYDAS model. Calibrated parameters were a "stemflow coefficient", which compartmented the plot; the saturated hydraulic conductivity (Ks, which controls infiltration and runoff; and the two parameters of the diffusive wave equation. We tested our model on a banana plot of 3000 m2 on permeable Andosol (mean Ks=75 mm h−1 under tropical rainfalls, in Guadeloupe (FWI. Runoff simulations without and with the stemflow function were performed and compared to 18 flood events from 10 to 140 rainfall mm depth. Modelling results showed that the stemflow function improved the calibration of hydrographs according to the error criteria on volume and on peakflow, to the Nash and Sutcliffe coefficient, and to the root mean square error. This was particularly the case for low flows observed during residual rainfall, for which the stemflow function allowed runoff to be simulated for rainfall intensities lower than the Ks measured at the soil surface. This approach also allowed us to take into account the experimental data

  14. Modelling runoff at the plot scale taking into account rainfall partitioning by vegetation: application to stemflow of banana (Musa spp.) plant

    Science.gov (United States)

    Charlier, J.-B.; Moussa, R.; Cattan, P.; Cabidoche, Y.-M.; Voltz, M.

    2009-11-01

    Rainfall partitioning by vegetation modifies the intensity of rainwater reaching the ground, which affects runoff generation. Incident rainfall is intercepted by the plant canopy and then redistributed into throughfall and stemflow. Rainfall intensities at the soil surface are therefore not spatially uniform, generating local variations of runoff production that are disregarded in runoff models. The aim of this paper was to model runoff at the plot scale, accounting for rainfall partitioning by vegetation in the case of plants concentrating rainwater at the plant foot and promoting stemflow. We developed a lumped modelling approach, including a stemflow function that divided the plot into two compartments: one compartment including stemflow and the related water pathways and one compartment for the rest of the plot. This stemflow function was coupled with a production function and a transfer function to simulate a flood hydrograph using the MHYDAS model. Calibrated parameters were a "stemflow coefficient", which compartmented the plot; the saturated hydraulic conductivity (Ks), which controls infiltration and runoff; and the two parameters of the diffusive wave equation. We tested our model on a banana plot of 3000 m2 on permeable Andosol (mean Ks=75 mm h-1) under tropical rainfalls, in Guadeloupe (FWI). Runoff simulations without and with the stemflow function were performed and compared to 18 flood events from 10 to 140 rainfall mm depth. Modelling results showed that the stemflow function improved the calibration of hydrographs according to the error criteria on volume and on peakflow, to the Nash and Sutcliffe coefficient, and to the root mean square error. This was particularly the case for low flows observed during residual rainfall, for which the stemflow function allowed runoff to be simulated for rainfall intensities lower than the Ks measured at the soil surface. This approach also allowed us to take into account the experimental data, without needing to

  15. A comprehensive survey of M(2)AX phase elastic properties.

    Science.gov (United States)

    Cover, M F; Warschkow, O; Bilek, M M M; McKenzie, D R

    2009-07-29

    M(2)AX phases are a family of nanolaminate, ternary alloys that are composed of slabs of transition metal carbide or nitride (M(2)X) separated by single atomic layers of a main group element. In this combination, they manifest many of the beneficial properties of both ceramic and metallic compounds, making them attractive for many technological applications. We report here the results of a large scale computational survey of the elastic properties of all 240 elemental combinations using first-principles density functional theory calculations. We found correlations revealing the governing role of the A element and its interaction with the M element on the c axis compressibility and shearability of the material. The role of the X element is relatively minor, with the strongest effect seen in the in-plane constants C(11) and C(12). We identify several elemental compositions with extremal properties such as W(2)SnC, which has by far the lowest value of C(44), suggesting potential applications as a high-temperature dry lubricant.

  16. Density Distribution Sunflower Plots in Stata Version 8

    OpenAIRE

    Dupont, William D

    2004-01-01

    Density distribution sunflower plots are used to display high-density bivariate data. They are useful for data where a conventional scatter plot is difficult to read due to overstriking of the plot symbol. The x-y plane is subdivided into a lattice of regular hexagonal bins of width w specified by the user. The user also specifies the values of l, d, and k that affect the plot as follows. Individual observations are plotted when there are less than l observations per bin as in a conventional ...

  17. Development of plotting position for the general extreme value distribution

    Science.gov (United States)

    Kim, Sooyoung; Shin, Hongjoon; Joo, Kyoungwon; Heo, Jun-Haeng

    2012-12-01

    SummaryProbability plotting positions are used to graphically display the annual maximum rainfall or flood and to estimate the exceedance probabilities of those values. Therefore, the graphical approach using plotting positions has been applied in many hydrology and water resource engineering fields. The definition of unbiased plotting positions by Cunnane (1978) as the mean of the order statistics from reduced variates has influenced researchers to develop the plotting position of the probability distribution containing shape parameters. In this study, the plotting position formula for the general extreme value (GEV) distribution was derived by using the theoretical reduced variates of the GEV distribution for various sample sizes and shape parameters. To choose an appropriate plotting position formula, we examined eight plotting position formula types containing coefficients of skewness or squared coefficients of skewness in the numerator and/or denominator. In addition, the parameters of the plotting position formula for the GEV distribution were estimated by using a genetic optimization method known as the real-coded genetic algorithm (RGA). The accuracy of the derived plotting position formula for the GEV distribution was examined on the basis of the root mean square errors and relative bias between the theoretical reduced variates and those calculated from the derived and existing plotting position formulas. The derived plotting formula was found to be useful if the range of the shape parameter was within ±0.2.

  18. Source apportionment advances using polar plots of bivariate correlation and regression statistics

    Science.gov (United States)

    Grange, Stuart K.; Lewis, Alastair C.; Carslaw, David C.

    2016-11-01

    This paper outlines the development of enhanced bivariate polar plots that allow the concentrations of two pollutants to be compared using pair-wise statistics for exploring the sources of atmospheric pollutants. The new method combines bivariate polar plots, which provide source characteristic information, with pair-wise statistics that provide information on how two pollutants are related to one another. The pair-wise statistics implemented include weighted Pearson correlation and slope from two linear regression methods. The development uses a Gaussian kernel to locally weight the statistical calculations on a wind speed-direction surface together with variable-scaling. Example applications of the enhanced polar plots are presented by using routine air quality data for two monitoring sites in London, United Kingdom for a single year (2013). The London examples demonstrate that the combination of bivariate polar plots, correlation, and regression techniques can offer considerable insight into air pollution source characteristics, which would be missed if only scatter plots and mean polar plots were used for analysis. Specifically, using correlation and slopes as pair-wise statistics, long-range transport processes were isolated and black carbon (BC) contributions to PM2.5 for a kerbside monitoring location were quantified. Wider applications and future advancements are also discussed.

  19. Second-order magnetic critical points at finite magnetic fields: Revisiting Arrott plots

    Science.gov (United States)

    Bustingorry, S.; Pomiro, F.; Aurelio, G.; Curiale, J.

    2016-06-01

    The so-called Arrott plot, which consists in plotting H /M against M2, with H the applied magnetic field and M the magnetization, is used to extract valuable information in second-order magnetic phase transitions. Besides, it is widely accepted that a negative slope in the Arrott plot is indicative of a first-order magnetic transition. This is known as the Banerjee criterion. In consequence, the zero-field transition temperature T* is reported as the characteristic first-order transition temperature. By carefully analyzing the mean-field Landau model used for studying first-order magnetic transitions, we show in this work that T* corresponds in fact to a triple point where three first-order lines meet. More importantly, this analysis reveals the existence of two symmetrical second-order critical points at finite magnetic field (Tc,±Hc) . We then show that a modified Arrott plot can be used to obtain information about these second-order critical points. To support this idea we analyze experimental data on La2 /3Ca1 /3MnO3 and discuss an estimate for the location of the triple point and the second-order critical points.

  20. Thermal testing results of an electroformed nickel secondary (M2) mirror

    Science.gov (United States)

    Smith, David R.; Gale, David M.; Cabrera Cuevas, Lizeth; Lucero Álvarez, Maribel; Castro Santos, David; Olmos Tapia, Arak

    2016-07-01

    To support higher-frequency operation, the Large Millimeter Telescope/Gran Telescopio Milimetrico (or LMT/GTM) is replacing its existing monolithic aluminum secondary mirror (M2). The new mirror is a segmented design based on the same electroformed nickel reflector panel technology that is already in use for the primary reflector segments. While the new M2 is lighter and has better surface accuracy than the original mirror, the electroformed panels are more sensitive to high temperatures. During the design phase, concerns were raised over the level of temperature increase that could occur at M2 during daytime observations. Although the panel surface is designed to scatter visible light, the LMT primary mirror is large enough to cause substantial solar heating, even at significant angular separation from the Sun. To address these concerns, the project conducted a series of field tests, within the constraint of having minimum impact on night time observations. The supplier sent two coupon samples of a reflector panel prepared identically to their proposed M2 surface. Temperature sensors were mounted on the samples and they were temporarily secured to the existing M2 mirror at different distances from the center. The goal was to obtain direct monitoring of the surface temperature under site thermal conditions and the concentration effects from the primary reflector. With the sensors installed, the telescope was then commanded to track the Sun with an elevation offset. Initially, elevation offsets from as far as 40 degrees to as close as 6 degrees were tested. The 6 degree separation test quickly passed the target maximum temperature and the telescope was returned to a safer separation. Based on these initial results, a second set of tests was performed using elevation separations from 30 degrees to 8 degrees. To account for the variability of site conditions, the temperature data were analyzed using multiple metrics. These metrics included maximum temperature, final

  1. iCanPlot: visual exploration of high-throughput omics data using interactive Canvas plotting.

    Directory of Open Access Journals (Sweden)

    Amit U Sinha

    Full Text Available Increasing use of high throughput genomic scale assays requires effective visualization and analysis techniques to facilitate data interpretation. Moreover, existing tools often require programming skills, which discourages bench scientists from examining their own data. We have created iCanPlot, a compelling platform for visual data exploration based on the latest technologies. Using the recently adopted HTML5 Canvas element, we have developed a highly interactive tool to visualize tabular data and identify interesting patterns in an intuitive fashion without the need of any specialized computing skills. A module for geneset overlap analysis has been implemented on the Google App Engine platform: when the user selects a region of interest in the plot, the genes in the region are analyzed on the fly. The visualization and analysis are amalgamated for a seamless experience. Further, users can easily upload their data for analysis--which also makes it simple to share the analysis with collaborators. We illustrate the power of iCanPlot by showing an example of how it can be used to interpret histone modifications in the context of gene expression.

  2. The Extreme Type I Planetary Nebula M2-52

    Directory of Open Access Journals (Sweden)

    M. Peña

    2002-01-01

    Full Text Available Se presentan los resultados obtenidos a partir de espectroscopía de alta resolución de la parte central de la nebulosa planetaria bipolar M2-52 que muestra un tipo morfológico Br. Hemos confirmado que M2-52 es una nebulosa de Tipo I de Peimbert, con un espectro rico en líneas de alto y bajo grado de ionización y un fuerte enriquecimiento de He y N. La composición química del gas ionizado es: He/H = 0:165 0:010, O/H = (2:6 0:5 x 10_4, N/O = 2:3 0:3, Ne/O = 0:37 0:10, Ar/O = (9:2 2:0 x 10_3 y S/O > 2:0 x 10_3. La velocidad de expansión de la nebulosa es, en promedio, de 20 2 km s_1 y varía ligeramente dependiendo del ión considerado. Los iones de menor grado de ionización, N+ y S+, muestran vexp _ 18 km s_1, O++ y He+ muestran vexp _ 20 km s_1, en tanto que He++ y H+ muestran vexp _ 22 km s_1. Es posible que la zona de N+ y S+ esté siendo frenada por el anillo de material molecular encontrado alrededor de la estrella.

  3. Marginal fluctuations as instantons on M2/D2-branes

    Energy Technology Data Exchange (ETDEWEB)

    Naghdi, M. [University of Ilam, Department of Physics, Faculty of Basic Sciences, Ilam (Iran, Islamic Republic of)

    2014-03-15

    We introduce some (anti-) M/D-branes through turning on the corresponding field strengths of the 11- and 10-dimensional supergravity theories over AdS{sub 4} x M{sup 7} {sup vertical} {sup stroke} {sup 6} spaces, where we use S{sup 7}/Z{sub k} and CP{sup 3} for the internal spaces. Indeed, when we add M2/D2-branes on the same directions with the near horizon branes of the Aharony-Bergman-Jafferis- Maldacena model, all symmetries and supersymmetries are preserved trivially. In this case, we obtain a localized object just in the horizon. This normalizable bulk massless scalar mode is a singlet of SO(8) and SU(4) x U(1), and it agrees with a marginal boundary operator of the conformal dimension of Δ{sub +} = 3. However, after performing a special conformal transformation, we see that the solution is localized in the Euclideanized AdS{sub 4} space and is attributable to the included anti-M2/D2-branes, which are also necessary to ensure that there is no back-reaction. The resultant theory now breaks all N = 8, 6 supersymmetries to N = 0, while the other symmetries are so preserved. The dual boundary operator is then set up from the skew-whiffing of the representations 8s and 8v for the supercharges and scalars, respectively, while the fermions remain fixed in 8c of the original theory. Besides, we also address another alternate bulk to boundary matching procedure through turning on one of the gauge fields of the full U(N){sub k} x U(N){sub -k} gauge group along the same lines with a similar situation to the one faced in the AdS{sub 5}/CFT{sub 4} correspondence. The latter approach covers the difficulty already faced with in the bulk-boundary matching procedure for k = 1, 2 as well. (orig.)

  4. Tracking Changes in Cardiac Output: Statistical Considerations on the 4-Quadrant Plot and the Polar Plot Methodology.

    Science.gov (United States)

    Saugel, Bernd; Grothe, Oliver; Wagner, Julia Y

    2015-08-01

    When comparing 2 technologies for measuring hemodynamic parameters with regard to their ability to track changes, 2 graphical tools are omnipresent in the literature: the 4-quadrant plot and the polar plot recently proposed by Critchley et al. The polar plot is thought to be the more advanced statistical tool, but care should be taken when it comes to its interpretation. The polar plot excludes possibly important measurements from the data. The polar plot transforms the data nonlinearily, which may prevent it from being seen clearly. In this article, we compare the 4-quadrant and the polar plot in detail and thoroughly describe advantages and limitations of each. We also discuss pitfalls concerning the methods to prepare the researcher for the sound use of both methods. Finally, we briefly revisit the Bland-Altman plot for the use in this context.

  5. Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes. Role of third intracellular m2 loop and G protein-coupled receptor kinase 2.

    Science.gov (United States)

    Tsuga, H; Kameyama, K; Haga, T; Honma, T; Lameh, J; Sadée, W

    1998-02-27

    Internalization and down-regulation of human muscarinic acetylcholine m2 receptors (hm2 receptors) and a hm2 receptor mutant lacking a central part of the third intracellular loop (I3-del m2 receptor) were examined in Chinese hamster ovary (CHO-K1) cells stably expressing these receptors and G protein-coupled receptor kinase 2 (GRK2). Agonist-induced internalization of up to 80-90% of hm2 receptors was demonstrated by measuring loss of [3H]N-methylscopolamine binding sites from the cell surface, and transfer of [3H]quinuclidinyl benzilate binding sites from the plasma membrane into the light-vesicle fractions separated by sucrose density gradient centrifugation. Additionally, translocation of hm2 receptors with endocytic vesicles were visualized by immunofluorescence confocal microscopy. Agonist-induced down-regulation of up to 60-70% of hm2 receptors was demonstrated by determining the loss of [3H]quinuclidinyl benzilate binding sites in the cells. The half-time (t1/2) of internalization and down-regulation in the presence of 10(-4) M carbamylcholine was estimated to be 9.5 min and 2.3 h, respectively. The rates of both internalization and down-regulation of hm2 receptors in the presence of 10(-6) M or lower concentrations of carbamylcholine were markedly increased by coexpression of GRK2. Agonist-induced internalization of I3-del m2 receptors was barely detectable upon incubation of cells for 1 h, but agonist-induced down-regulation of up to 40-50% of I3-del m2 receptors occurred upon incubation with 10(-4) M carbamylcholine for 16 h. However, the rate of down-regulation was lower compared with wild type receptors (t1/2 = 9.9 versus 2.3 h). These results indicate that rapid internalization of hm2 receptors is facilitated by their phosphorylation with GRK2 and does not occur in the absence of the third intracellular loop, but down-regulation of hm2 receptors may occur through both GRK2-facilitating pathway and third intracellular loop-independent pathways.

  6. Split-plot designs for robotic serial dilution assays.

    Science.gov (United States)

    Buzas, Jeffrey S; Wager, Carrie G; Lansky, David M

    2011-12-01

    This article explores effective implementation of split-plot designs in serial dilution bioassay using robots. We show that the shortest path for a robot to fill plate wells for a split-plot design is equivalent to the shortest common supersequence problem in combinatorics. We develop an algorithm for finding the shortest common supersequence, provide an R implementation, and explore the distribution of the number of steps required to implement split-plot designs for bioassay through simulation. We also show how to construct collections of split plots that can be filled in a minimal number of steps, thereby demonstrating that split-plot designs can be implemented with nearly the same effort as strip-plot designs. Finally, we provide guidelines for modeling data that result from these designs.

  7. Estimation of lattice strain in nanocrystalline RuO2 by Williamson-Hall and size-strain plot methods.

    Science.gov (United States)

    Sivakami, R; Dhanuskodi, S; Karvembu, R

    2016-01-01

    RuO2 nanoparticles (RuO2 NPs) have been successfully synthesized by the hydrothermal method. Structure and the particle size have been determined by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM) and transmission electron microscopy (TEM). UV-Vis spectra reveal that the optical band gap of RuO2 nanoparticles is red shifted from 3.95 to 3.55eV. BET measurements show a high specific surface area (SSA) of 118-133m(2)/g and pore diameter (10-25nm) has been estimated by Barret-Joyner-Halenda (BJH) method. The crystallite size and lattice strain in the samples have been investigated by Williamson-Hall (W-H) analysis assuming uniform deformation, deformation stress and deformation energy density, and the size-strain plot method. All other relevant physical parameters including stress, strain and energy density have been calculated. The average crystallite size and the lattice strain evaluated from XRD measurements are in good agreement with the results of TEM.

  8. Cross recurrence plot based synchronization of time series

    OpenAIRE

    N. Marwan; Thiel, M.; Nowaczyk, N. R.

    2002-01-01

    The method of recurrence plots is extended to the cross recurrence plots (CRP) which, among others, enables the study of synchronization or time differences in two time series. This is emphasized in a distorted main diagonal in the cross recurrence plot, the line of synchronization (LOS). A non-parametrical fit of this LOS can be used to rescale the time axis of the two data series (whereby one of them is compressed or stretched) so ...

  9. Recurrence plot statistics and the effect of embedding

    OpenAIRE

    March, T. K.; Chapman, S. C.; Dendy, R.O.

    2005-01-01

    Recurrence plots provide a graphical representation of the recurrent patterns in a timeseries, the quantification of which is a relatively new field. Here we derive analytical expressions which relate the values of key statistics, notably determinism and entropy of line length distribution, to the correlation sum as a function of embedding dimension. These expressions are obtained by deriving the transformation which generates an embedded recurrence plot from an unembedded plot. A single unem...

  10. Phase Plots of Complex Functions: a Journey in Illustration

    CERN Document Server

    Wegert, Elias

    2010-01-01

    We propose to visualize complex (meromorphic) functions $f$ by their phase $P_f:=f/|f|$. Color--coding the points on the unit circle converts the function $P_f$ to an image (the phase plot of $f$), which represents the function directly on its domain. We discuss how special properties of $f$ are reflected by their phase plots and indicate several applications. In particular we reformulate a universality theorem for Riemann's Zeta function in the language of phase plots.

  11. Ultrasonic beam-plotting with very small spheres.

    Science.gov (United States)

    Round, W H; Swan, H

    1991-12-01

    A method of pulse-echo ultrasonic beam plotting is described. It differs from traditional pulse-echo beam plotting in that the ultrasonic pulses are scattered off a totally isolated sphere rather than a sphere suspended on a wire. The method also allows extremely small spheres to be used thus providing greater resolution. It is demonstrated that pulse-echo beam plotting using spheres of different size produces different iso-echo amplitude curves.

  12. Multiwavelength photometry in the Globular Cluster M2

    CERN Document Server

    Dalessandro, E; Lanzoni, B; Ferraro, F R; Schiavon, R; Rood, R T

    2009-01-01

    We present a multiwavelength photometric analysis of the globular cluster M2. The data-set has been obtained by combining high-resolution (HST/WFPC2 and ACS) and wide-field (GALEX) space observations and ground based (MEGACAM-CFHT, EMMI-NTT) images. The photometric sample covers the entire cluster extension from the very central regions up to the tidal radius and beyond. It allows an accurate determination of the cluster center of gravity and other structural parameters derived from the star count density profile. Moreover we study the BSS population and its radial distribution. A total of 123 BSS has been selected, and their radial distribution has been found to be bimodal (highly peaked in the center, decreasing at intermediate radii and rising outward), as already found in a number of other clusters. The radial position of the minimum of the BSS distribution is consistent with the radius of avoidance caused by the dynamical friction of massive objects over the cluster age. We also searched for gradients in...

  13. Metric 3-Leibniz algebras and M2-branes

    CERN Document Server

    Méndez-Escobar, Elena

    2010-01-01

    This thesis is concerned with superconformal Chern-Simons theories with matter in 3 dimensions. The interest in these theories is two-fold. On the one hand, it is a new family of theories in which to test the AdS/CFT correspondence and on the other, they are important to study one of the main objects of M-theory (M2-branes). All these theories have something in common: they can be written in terms of 3-Leibniz algebras. Here we study the structure theory of such algebras, paying special attention to a subclass of them that gives rise to maximal supersymmetry and that was the first to appear in this context: 3-Lie algebras. In chapter 2, we review the structure theory of metric Lie algebras and their unitary representations. In chapter 3, we study metric 3-Leibniz algebras and show, by specialising a construction originally due to Faulkner, that they are in one to one correspondence with pairs of real metric Lie algebras and unitary representations of them. We also show a third characterisation for six extreme...

  14. Coarse-graining time series data: Recurrence plot of recurrence plots and its application for music.

    Science.gov (United States)

    Fukino, Miwa; Hirata, Yoshito; Aihara, Kazuyuki

    2016-02-01

    We propose a nonlinear time series method for characterizing two layers of regularity simultaneously. The key of the method is using the recurrence plots hierarchically, which allows us to preserve the underlying regularities behind the original time series. We demonstrate the proposed method with musical data. The proposed method enables us to visualize both the local and the global musical regularities or two different features at the same time. Furthermore, the determinism scores imply that the proposed method may be useful for analyzing emotional response to the music.

  15. Coarse-graining time series data: Recurrence plot of recurrence plots and its application for music

    Science.gov (United States)

    Fukino, Miwa; Hirata, Yoshito; Aihara, Kazuyuki

    2016-02-01

    We propose a nonlinear time series method for characterizing two layers of regularity simultaneously. The key of the method is using the recurrence plots hierarchically, which allows us to preserve the underlying regularities behind the original time series. We demonstrate the proposed method with musical data. The proposed method enables us to visualize both the local and the global musical regularities or two different features at the same time. Furthermore, the determinism scores imply that the proposed method may be useful for analyzing emotional response to the music.

  16. 试论修辞谋划%On Rhetorical Plot

    Institute of Scientific and Technical Information of China (English)

    江结宝

    2015-01-01

    Rhetorical plot is the overall design,scheme and specification. It can be divided into macro⁃scopic plot,medium plot and microscopic plot,with different types of general plot and special plot.. Rhetori⁃cal plot is the beginning of rhetorical process running through the whole rhetoric process. Rhetoric should pay attention to research of rhetoric plot. Rhetoric plot is different from rhetorical strategy.%修辞谋划是对修辞行为的整体设计、谋定和规约。修辞谋划可分为宏观谋划、中观谋划和微观谋划三个层次,包括一般谋划和特殊谋划两大类型。修辞谋划是修辞过程的起点,并贯穿整个修辞过程,修辞学应该重视修辞谋划的研究。修辞谋划不同于一般所说的“修辞策略”。

  17. Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype.

    Directory of Open Access Journals (Sweden)

    Rafael L Lopes

    Full Text Available Macrophages are myeloid cells that play an essential role in inflammation and host defense, regulating immune responses and maintaining tissue homeostasis. Depending on the microenvironment, macrophages can polarize to two distinct phenotypes. The M1 phenotype is activated by IFN-γ and bacterial products, and displays an inflammatory profile, while M2 macrophages are activated by IL-4 and tend to be anti-inflammatory or immunosupressive. It was observed that DnaK from Mycobacterium tuberculosis has immunosuppressive properties, inducing a tolerogenic phenotype in dendritic cells and MDSCs, contributing to graft acceptance and tumor growth. However, its role in macrophage polarization remains to be elucidated. We asked whether DnaK was able to modulate macrophage phenotype. Murine macrophages, derived from bone marrow, or from the peritoneum, were incubated with DnaK and their phenotype compared to M1 or M2 polarized macrophages. Treatment with DnaK leads macrophages to present higher arginase I activity, IL-10 production and FIZZ1 and Ym1 expression. Furthermore, DnaK increased surface levels of CD206. Importantly, DnaK-treated macrophages were able to promote tumor growth in an allogeneic melanoma model. Our results suggest that DnaK polarizes macrophages to the M2-like phenotype and could constitute a virulence factor and is an important immunomodulator of macrophage responses.

  18. A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop.

    Science.gov (United States)

    Hawthorne, Rebecca; Lynch, Joseph W

    2005-10-28

    The external loop linking the M2 and M3 transmembrane domains is crucial for coupling agonist binding to channel gating in the glycine receptor chloride channel (GlyR). A substituted cysteine accessibility scan previously showed that glycine activation increased the surface accessibility of 6 contiguous residues (Arg271-Lys276) toward the N-terminal end of the homomeric alpha1 GlyR M2-M3 loop. In the present study we used a similar approach to determine whether the allosteric antagonist, picrotoxin, could impose conformational changes to this domain that cannot be induced by varying agonist concentrations alone. Picrotoxin slowed the reaction rate of a sulfhydryl-containing compound (MTSET) with A272C, S273C, and L274C. Before interpreting this as a picrotoxin-specific conformational change, it was necessary to eliminate the possibility of steric competition between picrotoxin and MTSET. Accordingly, we showed that picrotoxin and the structurally unrelated blocker, bilobalide, were both trapped in the R271C GlyR in the closed state and that a point mutation to the pore-lining Thr6' residue abolished inhibition by both compounds. We also demonstrated that the picrotoxin dissociation rate was linearly related to the channel open probability. These observations constitute a strong case for picrotoxin binding in the pore. We thus conclude that the picrotoxin-specific effects on the M2-M3 loop are mediated allosterically. This suggests that the M2-M3 loop responds differently to the occupation of different binding sites.

  19. Fungicides transport in runoff from vineyard plot and catchment: contribution of non-target areas.

    Science.gov (United States)

    Lefrancq, Marie; Payraudeau, Sylvain; García Verdú, Antonio Joaquín; Maillard, Elodie; Millet, Maurice; Imfeld, Gwenaël

    2014-04-01

    Surface runoff and erosion during the course of rainfall events are major processes of pesticides transport from agricultural land to aquatic ecosystem. These processes are generally evaluated either at the plot or the catchment scale. Here, we compared at both scales the transport and partitioning in runoff water of two widely used fungicides, i.e., kresoxim-methyl (KM) and cyazofamid (CY). The objective was to evaluate the relationship between fungicides runoff from the plot and from the vineyard catchment. The results show that seasonal exports for KM and CY at the catchment were larger than those obtained at the plot. This underlines that non-target areas within the catchment largely contribute to the overall load of runoff-associated fungicides. Estimations show that 85 and 62 % of the loads observed for KM and CY at the catchment outlet cannot be explained by the vineyard plots. However, the partitioning of KM and CY between three fractions, i.e., the suspended solids (>0.7 μm) and two dissolved fractions (i.e., between 0.22 and 0.7 µm and catchment and the plot scales enable to evaluate the sources areas of pesticide off-site transport.

  20. A Guided Inquiry on Hubble Plots and the Big Bang

    Science.gov (United States)

    Forringer, Ted

    2014-01-01

    In our science for non-science majors course "21st Century Physics," we investigate modern "Hubble plots" (plots of velocity versus distance for deep space objects) in order to discuss the Big Bang, dark matter, and dark energy. There are two potential challenges that our students face when encountering these topics for the…

  1. Development of gnuplot plotting package for MAD-X

    CERN Document Server

    Romero Leiro, Freddy Jose

    2015-01-01

    MAD-X is a general purpose software for charged-particle optics design and it needs a visualisation tool to be able to show the data in a more manageable way, this visualisation tools being already in MAD-X are the PLOT and SETPLOT commands. Nonetheless issues like compatibility and the desire of having alternative ways to show the plots in a more portable way have lead to explore the use of open source available software to reproduce the same results. The purpose of this project is to create a package compatible with the MAD-X output format, capable of generating publication quality plots, mainly lattice beamline plots and scatter plots by using the Gnuplot for creating plots. This software must support the same options as the PLOT and SETPLOT commands from MAD-X but additions or improvement over the present version are more than welcome. The main purpose of the program is to pre-process the data in order to be ready for Gnuplot to read it and plot it .This report is mostly a description of the development o...

  2. Conceptual recurrence plots: revealing patterns in human discourse.

    Science.gov (United States)

    Angus, Daniel; Smith, Andrew; Wiles, Janet

    2012-06-01

    Human discourse contains a rich mixture of conceptual information. Visualization of the global and local patterns within this data stream is a complex and challenging problem. Recurrence plots are an information visualization technique that can reveal trends and features in complex time series data. The recurrence plot technique works by measuring the similarity of points in a time series to all other points in the same time series and plotting the results in two dimensions. Previous studies have applied recurrence plotting techniques to textual data; however, these approaches plot recurrence using term-based similarity rather than conceptual similarity of the text. We introduce conceptual recurrence plots, which use a model of language to measure similarity between pairs of text utterances, and the similarity of all utterances is measured and displayed. In this paper, we explore how the descriptive power of the recurrence plotting technique can be used to discover patterns of interaction across a series of conversation transcripts. The results suggest that the conceptual recurrence plotting technique is a useful tool for exploring the structure of human discourse.

  3. Recurrence plots from altimetry data of some lakes in Africa

    CERN Document Server

    Sparavigna, Amelia Carolina

    2014-01-01

    The paper shows recurrence plots obtained from time series of the level variations of four lakes in Africa (Nasser, Tana, Chad and Kainji). The data, coming from remote sensing, are provided by the United States Department of Agriculture. The recurrence plots allow a good visual comparison of the behaviours of local drainage basins.

  4. A Guided Inquiry on Hubble Plots and the Big Bang

    Science.gov (United States)

    Forringer, Ted

    2014-01-01

    In our science for non-science majors course "21st Century Physics," we investigate modern "Hubble plots" (plots of velocity versus distance for deep space objects) in order to discuss the Big Bang, dark matter, and dark energy. There are two potential challenges that our students face when encountering these topics for the…

  5. Instrumentation for full-year plot-scale runoff monitoring

    Science.gov (United States)

    Replicated 0.34 ha cropping systems plots have been in place since 1991 at the USDA-ARS Goodwater Creek Experimental Watershed in central Missouri. Recently, instrumentation has been installed at 18 of those plots for continuous runoff water quality and quantity monitoring. That installation require...

  6. Precise FIA plot registration using field and dense LIDAR data

    Science.gov (United States)

    Demetrios Gatziolis

    2009-01-01

    Precise registration of forest inventory and analysis (FIA) plots is a prerequisite for an effective fusion of field data with ancillary spatial information, which is an approach commonly employed in the mapping of various forest parameters. Although the adoption of Global Positioning System technology has improved the precision of plot coordinates obtained during...

  7. Weak limits for exploratory plots in the analysis of extremes

    CERN Document Server

    Das, Bikramjit

    2010-01-01

    Exploratory plotting tools have been devised aplenty in order to diagnose the goodness-of-fit of data sets to a hypothesized distribution. Some of them have found extensive use in diverse areas of finance, telecommunication, environmental science, etc. in order to detect sub-exponential or heavy-tailed behavior in observed data. In this paper we concentrate on two such plotting methodologies: the Quantile-Quantile plots for heavy-tails and the Mean Excess plots. Under the assumption of heavy-tailed behavior of the underlying sample the convergence in probability of these plots to a fixed set in a suitable topology of closed sets of $\\R^2$ has been studied in \\cite{das:resnick:2008} and \\cite{ghosh:resnick:2009}. These results give theoretical justifications for using the plots to test the null hypothesis that the underlying distribution is heavy-tailed by checking if the observed plot is ``close'' to the limit under the null hypothesis. In practice though one set of observations would lead to only one plot of...

  8. RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes.

    Science.gov (United States)

    Foldi, Julia; Shang, Yingli; Zhao, Baohong; Ivashkiv, Lionel B; Hu, Xiaoyu

    2016-03-01

    Development of alternatively activated (M2) macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors. Here, we report that RBP-J, a DNA-binding protein that integrates signals from multiple pathways including the Notch pathway, is critically involved in polarization of M2 macrophages. Mice deficient in RBP-J in the myeloid compartment exhibited impaired M2 phenotypes in vivo in a chitin-induced model of M2 polarization. Consistent with the in vivo findings, M2 polarization was partially compromised in vitro in Rbpj-deficient macrophages as demonstrated by reduced expression of a subset of M2 effector molecules including arginase 1. Functionally, myeloid Rbpj deficiency impaired M2 effector functions including recruitment of eosinophils and suppression of T cell proliferation. Collectively, we have identified RBP-J as an essential regulator of differentiation and function of alternatively activated macrophages.

  9. Split-plot fractional designs: Is minimum aberration enough?

    DEFF Research Database (Denmark)

    Kulahci, Murat; Ramirez, Jose; Tobias, Randy

    2006-01-01

    Split-plot experiments are commonly used in industry for product and process improvement. Recent articles on designing split-plot experiments concentrate on minimum aberration as the design criterion. Minimum aberration has been criticized as a design criterion for completely randomized fractional...... factorial design and alternative criteria, such as the maximum number of clear two-factor interactions, are suggested (Wu and Hamada (2000)). The need for alternatives to minimum aberration is even more acute for split-plot designs. In a standard split-plot design, there are several types of two...... for completely randomized designs. Consequently, we provide a modified version of the maximum number of clear two-factor interactions design criterion to be used for split-plot designs....

  10. Superplot: Graphical interface for plotting and analyzing data

    Science.gov (United States)

    Fowlie, Andrew; Bardsley, Michael Hugh

    2016-12-01

    Superplot calculates and plots statistical quantities relevant to parameter inference from a "chain" of samples drawn from a parameter space produced by codes such as MultiNest (ascl:1109.006), BAYES-X (ascl:1505.027), and PolyChord (ascl:1502.011). It offers a graphical interface for browsing a chain of many variables quickly and can produce numerous kinds of publication quality plots, including one- and two-dimensional profile likelihood, three-dimensional scatter plots, and confidence intervals and credible regions. Superplot can also save plots in PDF format, create a summary text file, and export a plot as a pickled object for importing and manipulating in a Python interpreter.

  11. Split-plot fractional designs: Is minimum aberration enough?

    DEFF Research Database (Denmark)

    Kulahci, Murat; Ramirez, Jose; Tobias, Randy

    2006-01-01

    Split-plot experiments are commonly used in industry for product and process improvement. Recent articles on designing split-plot experiments concentrate on minimum aberration as the design criterion. Minimum aberration has been criticized as a design criterion for completely randomized fractional...... factorial design and alternative criteria, such as the maximum number of clear two-factor interactions, are suggested (Wu and Hamada (2000)). The need for alternatives to minimum aberration is even more acute for split-plot designs. In a standard split-plot design, there are several types of two...... for completely randomized designs. Consequently, we provide a modified version of the maximum number of clear two-factor interactions design criterion to be used for split-plot designs....

  12. Haemophilus ducreyi-induced interleukin-10 promotes a mixed M1 and M2 activation program in human macrophages.

    Science.gov (United States)

    Li, Wei; Katz, Barry P; Spinola, Stanley M

    2012-12-01

    During microbial infection, macrophages are polarized to classically activated (M1) or alternatively activated (M2) cells in response to microbial components and host immune mediators. Proper polarization of macrophages is critical for bacterial clearance. To study the role of macrophage polarization during Haemophilus ducreyi infection, we analyzed a panel of macrophage surface markers in skin biopsy specimens of pustules obtained from experimentally infected volunteers. Lesional macrophages expressed markers characteristic of both M1 and M2 polarization. Monocyte-derived macrophages (MDM) also expressed a mixed M1 and M2 profile of surface markers and cytokines/chemokines upon infection with H. ducreyi in vitro. Endogenous interleukin 10 (IL-10) produced by infected MDM downregulated and enhanced expression of several M1 and M2 markers, respectively. Bacterial uptake, mediated mainly by class A scavenger receptors, and activation of mitogen-activated protein kinase and phosphoinositide 3-kinase signaling pathways were required for H. ducreyi-induced IL-10 production in MDM. Compared to M1 cells, IL-10-polarized M2 cells displayed enhanced phagocytic activity against H. ducreyi and similar bacterial killing. Thus, IL-10-modulated macrophage polarization may contribute to H. ducreyi clearance during human infection.

  13. Construction of Recombinant Bacmid Containing M2e-Ctxb and Producing the Fusion Protein in Insect Cell Lines

    Science.gov (United States)

    Mirzaei, Nima; Mokhtari Azad, Talat; Nategh, Rakhshandeh; Soleimanjahi, Hoorieh; Amirmozafari, Nour

    2014-01-01

    Background: Sequence variations in glycoproteins of influenza virus surface impel us to design new candidate vaccines yearly. Ectodomain of influenza M2 protein is a surface and highly conserved protein. M2e in influenza vaccines may eliminate the need for changing vaccine formulation every year. Objectives: In this study, a recombinant baculovirus containing M2e and cholera toxin subunit B fusion gene was generated with transposition process to express in large amounts in insect cell lines. Materials and Methods: M2e-ctxB fusion gene was created and cloned into pFastBac HT. The recombinant vector was transformed into DH10Bac cells to introduce the fusion gene into the bacmid DNA via a site-specific transposition process. The recombinant bacmid was then extracted from white colonies and further analyzed using PCR, DNA sequence analyzing, and indirect immunofluorescence assay. Results: PCR and DNA sequence analyzing results showed that the fusion gene was constructed as a single open reading frame and was successfully inserted into bacmid DNA. Moreover, indirect immunofluorescence results showed that the fusion gene was successfully expressed. Conclusions: Baculovirus expression vector system is valuable to produce M2e based influenza vaccines due to its simple utilization and ease of target gene manipulation. The expressed protein in such systems can improve the evaluating process of new vaccination strategies. PMID:24719728

  14. Infiltration and water storage in forest soils at the plot and the micro- catchment scale

    Science.gov (United States)

    Stimm, Eva-Maria; Lange, Benjamin; Lüscher, Peter; Germann, Peter; Weingartner, Rolf

    2010-05-01

    Tree roots generate and conserve hydrologically active macropores. We explored the influence of root density on infiltration and water storage at six 1-m2 plots along an 8-m transect between two mature trees (spruce). The soil is a Flysch-based stagnic Cambisol with a flow-impeding horizon at a depth of about 60 cm. At a plot the experimental set up consisted of a 1m x 1m sprinkler and five Decagon HS-10 soil-moisture probes that were horizontally mounted from a trench into the centre of each horizon. We irrigated each plot three times at 24-hour intervals during one hour with a rate of 70 mm h-1. Data logging was at 60-seconds intervals that produced time series of water contents due to irrigation and drainage. After irrigation, soil cores of 10 cm diameter were sampled. Roots were extracted from the cores and their densities were optically analysed with the program "whinRIZO". The application of a rivulet approach to the time series of water contents produced the thickness F (μm) and the specific contact length L (m m-2) per cross-sectional area of the water films that represent Stokes-flow. The procedure leads to estimates of storage capacity and hydraulic connectivity in the vertical and lateral directions along the transect. Extrapolation from the transect to the micro-catchment scale is based on maps showing the spatial arrangements of trees, shrubs and soil properties like thickness and hydrological parameters of horizons.

  15. Reseach on Business Model of M2M Virtual Opertion%M2M虚拟运营的商业模式研究

    Institute of Scientific and Technical Information of China (English)

    景士颖; 乔新春

    2014-01-01

    M2M市场在未来几年拥有较大的增长空间,随着移动转售业务牌照的发放,M2M将成为虚拟运营商可以切入的具备潜力的市场领域之一。探讨M2M虚拟运营的商业模式,分析国际开展M2M虚拟运营的案例,并给出国内开展M2M虚拟运营的建议。%M2M has more market space for growth in the coming years, with the issuance of mobile resale service license, M2M wil become a potential market area where MVNOs can cut into. This article discusses the business model of M2M virtual operation, analyzes the international M2M MVNO business cases, and gives advices to MNOs and MVNOs on how to provide better M2M services in China.

  16. M2e通用流感疫苗的研究进展%Universal influenza vaccine based on the extracellular domain of M2 protein

    Institute of Scientific and Technical Information of China (English)

    花艳红; 王希良

    2009-01-01

    M2基质蛋白是A型流感病毒膜蛋白,在A型流感病毒的生命周期中,M2具有重要的生物学功能,已成为抗病毒药物研究的靶蛋白.其胞外区M2e(M2 eetodomain,M2e)为24个氨基酸残基,该片段在多病毒株中具有极高的保守性.针对M2e产生IgG型抗体能够防止流感病毒引发的死亡,减少动物模型中流感的发病率.了解有关M2e疫苗的研究进展,以及关于M2e作为A型流感疫苗靶抗原的关键问题很重要.%Matrix protein M2 (M2) is the membrane protein of Influenza A with an extracellular domain of 24 amino acid residues, which is strongly conserved across virus strains. M2 plays an important role in the life cy-cle of the Influenza A virus and has been the target of antiviral drugs. IgG subtype antibodies directed against M2e can prevent death from influenza and reduce morbidity in animal models for influenza disease. This review summarizes the findings on M2e vaccine candidates and addresses some key questions about this Influenza A vaccine target.

  17. Protection against multiple influenza A virus strains induced by candidate recombinant vaccine based on heterologous M2e peptides linked to flagellin.

    Directory of Open Access Journals (Sweden)

    Liudmila A Stepanova

    Full Text Available Matrix 2 protein ectodomain (M2e is considered a promising candidate for a broadly protective influenza vaccine. M2e-based vaccines against human influenza A provide only partial protection against avian influenza viruses because of differences in the M2e sequences. In this work, we evaluated the possibility of obtaining equal protection and immune response by using recombinant protein on the basis of flagellin as a carrier of the M2e peptides of human and avian influenza A viruses. Recombinant protein was generated by the fusion of two tandem copies of consensus M2e sequence from human influenza A and two copies of M2e from avian A/H5N1 viruses to flagellin (Flg-2M2eh2M2ek. Intranasal immunisation of Balb/c mice with recombinant protein significantly elicited anti-M2e IgG in serum, IgG and sIgA in BAL. Antibodies induced by the fusion protein Flg-2M2eh2M2ek bound efficiently to synthetic peptides corresponding to the human consensus M2e sequence as well as to the M2e sequence of A/Chicken/Kurgan/05/05 RG (H5N1 and recognised native M2e epitopes exposed on the surface of the MDCK cells infected with A/PR/8/34 (H1N1 and A/Chicken/Kurgan/05/05 RG (H5N1 to an equal degree. Immunisation led to both anti-M2e IgG1 and IgG2a response with IgG1 prevalence. We observed a significant intracellular production of IL-4, but not IFN-γ, by CD4+ T-cells in spleen of mice following immunisation with Flg-2M2eh2M2ek. Immunisation with the Flg-2M2eh2M2ek fusion protein provided similar protection from lethal challenge with human influenza A viruses (H1N1, H3N2 and avian influenza virus (H5N1. Immunised mice experienced significantly less weight loss and decreased lung viral titres compared to control mice. The data obtained show the potential for the development of an M2e-flagellin candidate influenza vaccine with broad spectrum protection against influenza A viruses of various origins.

  18. Protection against Multiple Influenza A Virus Strains Induced by Candidate Recombinant Vaccine Based on Heterologous M2e Peptides Linked to Flagellin

    Science.gov (United States)

    Kovaleva, Anna A.; Potapchuk, Marina V.; Korotkov, Alexandr V.; Sergeeva, Mariia V.; Kasianenko, Marina A.; Kuprianov, Victor V.; Ravin, Nikolai V.; Tsybalova, Liudmila M.; Skryabin, Konstantin G.; Kiselev, Oleg I.

    2015-01-01

    Matrix 2 protein ectodomain (M2e) is considered a promising candidate for a broadly protective influenza vaccine. M2e-based vaccines against human influenza A provide only partial protection against avian influenza viruses because of differences in the M2e sequences. In this work, we evaluated the possibility of obtaining equal protection and immune response by using recombinant protein on the basis of flagellin as a carrier of the M2e peptides of human and avian influenza A viruses. Recombinant protein was generated by the fusion of two tandem copies of consensus M2e sequence from human influenza A and two copies of M2e from avian A/H5N1 viruses to flagellin (Flg-2M2eh2M2ek). Intranasal immunisation of Balb/c mice with recombinant protein significantly elicited anti-M2e IgG in serum, IgG and sIgA in BAL. Antibodies induced by the fusion protein Flg-2M2eh2M2ek bound efficiently to synthetic peptides corresponding to the human consensus M2e sequence as well as to the M2e sequence of A/Chicken/Kurgan/05/05 RG (H5N1) and recognised native M2e epitopes exposed on the surface of the MDCK cells infected with A/PR/8/34 (H1N1) and A/Chicken/Kurgan/05/05 RG (H5N1) to an equal degree. Immunisation led to both anti-M2e IgG1 and IgG2a response with IgG1 prevalence. We observed a significant intracellular production of IL-4, but not IFN-γ, by CD4+ T-cells in spleen of mice following immunisation with Flg-2M2eh2M2ek. Immunisation with the Flg-2M2eh2M2ek fusion protein provided similar protection from lethal challenge with human influenza A viruses (H1N1, H3N2) and avian influenza virus (H5N1). Immunised mice experienced significantly less weight loss and decreased lung viral titres compared to control mice. The data obtained show the potential for the development of an M2e-flagellin candidate influenza vaccine with broad spectrum protection against influenza A viruses of various origins. PMID:25799221

  19. Soil erosion measurements by means of experimental plots to determine best land management strategies in vineyards and olive orchards

    Science.gov (United States)

    Cerdà, Artemi; Keesstra, Saskia; Jordan, Antonio; Brevik, Erik; Nova, Agata; Prosdocimi, Massimo; Azorín-Molina, César; Yazdanpanah, Najme; Mahmoodabadi, Majid; Pereira, Paulo; Burguet, María

    2016-04-01

    In order to design sustainable land management there is a need to have accurate information on the impact this land management strategies have on water and sediment dynamics. This is especially important when a proper management is designed to reduce the soil losses due to the complex interaction of mechanisms that interact within the soil erosion process. Soil erosion is an non-linear process, both spatially and temporally, and as a consequence of that only well-monitored and accurate measurements can give insights in the processes and how these processes can be influenced by management to reduce soil losses (Cerdà, 2007; Ligonja and Shrestha, 2015; Nanko et al., 2015; Seutloali and Beckedahl, 2015). This is necessary at different scales: pedon, slope, and watershed because the governing processes differ at different scale (Keesstra, 2007; Jordán and Martínez Zavala, 2008; Borrelli et al., 2015). Soil erosion plots can give information about the temporal and spatial variability of soil losses. We present here a strategy developed by the Soil Erosion and Degradation Research Group from the University of Valencia to assess the soil erosion rates in Eastern Spain. In 2002 the Soil Erosion Experimental Station in El Teularet-Sierra de Enguera was installed, to assess soil losses in rainfed agriculture orchards, and 73 plots of 1, 2, 4, 16 and 48 m2 were installed. In 2005 6 plots of 300 m2 were installed in the nearby Montesa soil erosion station to assess soil losses in citrus orchards. In 2011 16 plots of 2 m2 where installed in Les Alcusses to determine soil losses in olive orchards, and in 2015 8 plots in Celler del Roure vineyard to assess the impact of land management in vineyards and 8 plots in the El Teularet to study the impact of straw mulch on soil erosion rates. All erosion stations are located in several kilometres distance from each other. This research which we developed since 2002 is complementary to previous research where we used rainfall

  20. The physical model of a terraced plot: first results

    Science.gov (United States)

    Perlotto, Chiara; D'Agostino, Vincenzo; Buzzanca, Giacomo

    2017-04-01

    Terrace building have been expanded in the 19th century because of the increased demographic pressure and the need to crop additional areas at steeper slopes. Terraces are also important to regulate the hydrological behavior of the hillslope. Few studies are available in literature on rainfall-runoff processes and flood risk mitigation in terraced areas. Bench terraces, reducing the terrain slope and the length of the overland flow, quantitatively control the runoff flow velocity, facilitating the drainage and thus leading to a reduction of soil erosion. The study of the hydrologic-hydraulic function of terraced slopes is essential in order to evaluate their possible use to cooperate for flood-risk mitigation also preserving the landscape value. This research aims to better focus the times of the hydrological response, which are determined by a hillslope plot bounded by a dry-stone wall, considering both the overland flow and the groundwater. A physical model, characterized by a quasi-real scale, has been built to reproduce the behavior of a 3% outward sloped terrace at bare soil condition. The model consists of a steel metal box (1 m large, 3.3 m long, 2 m high) containing the hillslope terrain. The terrain is equipped with two piezometers, 9 TDR sensors measuring the volumetric water content, a surface spillway at the head releasing the steady discharge under test, a scale at the wall base to measure the outflowing discharge. The experiments deal with different initial moisture condition (non-saturated and saturated), and discharges of 19.5, 12.0 and 5.0 l/min. Each experiment has been replicated, conducting a total number of 12 tests. The volumetric water content analysis produced by the 9 TDR sensors was able to provide a quite satisfactory representation of the soil moisture during the runs. Then, different lag times at the outlet since the inflow initiation were measured both for runoff and groundwater. Moreover, the time of depletion and the piezometer

  1. VTM plots as evidence of historical change: Goldmine or landmine?

    Science.gov (United States)

    Keeley, Jon E.

    2004-01-01

    VTM (Vegetation Type Map) plots comprise a huge data set on vegetation composition for many parts of California collected mostly between 1929 and 1935. Historical changes in vegetation have been inferred by sampling these areas many decades later and evaluating the changes in plant dominance. VTM plots can not be precisely relocated, and it has been assumed that errors resulting from this problem are inconsequential or can be eliminated by comparison with a composite of multiple contemporary plots. This study examines that assumption for southern California shrubland landscapes by comparing the differences in species composition between closely positioned VTM-sized plots. Comparing shrub species density in 400-m² plots separated by 30 m (center to center), I found that all species exhibited considerable differences in density even over this short distance. This patchiness in shrub distribution could lead to major errors in historical reconstructions from VTM plot data. Two methods are proposed for dealing with this problem. One is to collect multiple samples from the vicinity of the VTM plot and use the observed spatial variation to set bounds on the temporal changes required to represent significant historical change. The other is to look at broad landscape changes reflected in the averages observed in a large sampling of sites.

  2. Evaluation of a Smartphone App for Forest Sample Plot Measurements

    Directory of Open Access Journals (Sweden)

    Mikko Vastaranta

    2015-04-01

    Full Text Available We evaluated a smartphone app (TRESTIMATM for forest sample plot measurements. The app interprets imagery collected from the sample plots using the camera in the smartphone and then estimates forest inventory attributes, including species-specific basal areas (G as well as the diameter (DgM and height (HgM of basal area median trees. The estimates from the smartphone app were compared to forest inventory attributes derived from tree-wise measurements using calipers and a Vertex height measurement device. The data consist of 2169 measured trees from 25 sample plots (32 m × 32 m, dominated by Scots pine and Norway spruce from southern Finland. The root-mean-square errors (RMSEs in the basal area varied from 19.7% to 29.3% and the biases from 11.4% to 18.4% depending on the number of images per sample plot and image shooting location. DgM measurement bias varied from −1.4% to 3.1% and RMSE from 5.2% to 11.6% depending on the tree species. Respectively, HgM bias varied from 5.0% to 8.3% and RMSE 10.0% to 13.6%. In general, four images captured toward the center of the plot provided more accurate results than four images captured away from the plot center. Increasing the number of captured images per plot to the analyses yielded only marginal improvement to the results.

  3. Using Zoom Technologies to Display HEP Plots and Talks

    Science.gov (United States)

    Watts, G.

    2012-12-01

    Particle physics conferences and experiments generate a huge number of plots and presentations. It is impossible to keep up. A typical conference (like CHEP) will have 100's of plots. A single analysis result from a major experiment will have almost 50 plots. Scanning a conference or sorting out what plots are new is almost a full time job. The advent of multi-core computing and advanced video cards means that we have more processor power available for visualization than any time in the past. This poster describes two related projects that take advantage of this to solve the viewing problem. The first, Collider Plots, has a backend that looks for new plots released by ATLAS, CMS, CDF, and DZERO and organizes them by date, by experiment, and by subgroup for easy viewing and sorting. It maintains links back to associated conference notes and web pages with full result information. The second project, Deep Conference, renders all the slides as a single large zoomable picture. In both cases, much like a web mapping program, details are revealed as you zoom in. In the case of Collider Plots the plots are stacked as histograms to give visual clues for the most recent updates and activity have occurred. Standard plug-in software for a browser allows a user to zoom in on a portion of the conference that looks interesting. As the user zooms further more and more details become visible, allowing the user to make a quick and cheap decision on whether to spend more time on a particular talk or series of plots. Both projects are available at http://deeptalk.phys.washington.edu. The poster discusses the implementation and use as well as cross platform performance and possible future directions.

  4. Effect of sheet and rill erosion on overland flow connectivity in bare agricultural plots

    Science.gov (United States)

    Penuela Fernandez, Andres; Rocio Rodriguez Pleguezuelo, Carmen; Javaux, Mathieu; Bielders, Charles L.

    2014-05-01

    Rill erosion processes generate preferential flow paths that may increase the degree of connectivity of the soil surface and hence strongly modify its hydrological response. However, few studies have tried to quantify the effect of rill development on overland flow connectivity. For this purpose, changes in surface microtopography were monitored on three bare agricultural plots (3 m wide x 10 m long and 11% of slope) in Louvain-la-Neuve (Belgium) under natural rainfall conditions. Digital elevation models of these plots were obtained on a monthly basis over a 1-year period by photogrammetry using the Micmac software. Runoff was collected at the plot outlets. To characterize the hydrological connectivity, a functional connectivity indicator was used, called the relative surface connection function (RSCf). This indicator, which relates the area connected to the outflow boundary to the degree of filling of maximum depression storage (MDS), is fast to compute and was previously shown to be able to capture runoff-relevant connectivity properties. The RSC function was calculated for each DEM and the evolution of overland flow connectivity was quantified and compared to the measured runoff. The results of this study showed that the changes in microtopography resulting from sheet and rill erosion have a strong impact on the hydrological connectivity as reflected in the RSCf. A higher volume of runoff was generated as a consequence of surface sealing and the decrease of the MDS. More rapid runoff initiation was observed as the RSCf evolved from a concave to a convex shape.

  5. Analysing spatially extended high-dimensional chaos by recurrence plots

    CERN Document Server

    Marwana, Norbert; Foerster, Saskia

    2014-01-01

    Recurrence plot based measures of complexity are capable tools for characterizing complex dynamics. In this letter we show the potential of selected recurrence plot measures for the investigation of even high-dimensional chaos. We apply this method on spatially extended chaos, such as derived from the Lorenz96 model and show that the recurrence plot based measures can qualitatively characterize typical dynamical properties such as chaotic or periodic dynamics. Moreover, we demonstrate its power by analyzing satellite image time series of vegetation cover with contrasting dynamics as a high-dimensional example from the real world.

  6. Recurrence plot analysis of spatially extended high-dimensional dynamics

    Science.gov (United States)

    Marwan, Norbert; Foerster, Saskia; Kurths, Jürgen

    2015-04-01

    Recurrence plot based measures of complexity are capable tools for characterizing complex dynamics. We show the potential of selected recurrence plot measures for the investigation of spatially extended high-dimensional dynamics by applying them to data from the Lorenz96 model. The recurrence plot based measures are able to qualitatively characterize typical dynamical properties such as chaotic or periodic dynamics. Moreover, we demonstrate its power by analyzing satellite image time series of vegetation cover with contrasting dynamics as a spatially extended and potentially high-dimensional example from the real world.

  7. Analysing spatially extended high-dimensional dynamics by recurrence plots

    Science.gov (United States)

    Marwan, Norbert; Foerster, Saskia; Kurths, Jürgen

    2016-04-01

    Recurrence plot based measures of complexity are capable tools for characterizing complex dynamics. We show the potential of selected recurrence plot measures for the investigation of even high-dimensional dynamics. We apply this method on spatially extended chaos, such as derived from the Lorenz96 model and show that the recurrence plot based measures can qualitatively characterize typical dynamical properties such as chaotic or periodic dynamics. Moreover, we demonstrate its power by analyzing satellite image time series of vegetation cover with contrasting dynamics as a spatially extended and potentially high-dimensional example from the real world.

  8. An Analysis of Property Rights in Privately Owned Family Plots

    Institute of Scientific and Technical Information of China (English)

    MengXiangzhong

    2005-01-01

    In the present Chinese system of rural land ownership, family plots still supplement the collectively-owned rural economy. As they occupy a very small proportion of the total amount of arable land, there has been little study of their economic effects; indeed, they have been totally neglected. In the past, under the planned economy, family plots could provide a diversified source of livelihood for Chinese farmers; at present, they have become a “bottleneck” obstructing the further industrialization of the rural economy. First of all, the ownership system for family plots fragments the system of land ownership, hindering the legal circulation of land-use,

  9. Dalitz plot distributions in presence of triangle singularities

    Energy Technology Data Exchange (ETDEWEB)

    Szczepaniak, Adam P., E-mail: aszczepa@indiana.edu [Department of Physics, Indiana University, Bloomington, IN 47405 (United States); Theory Center, Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Center for Exploration of Energy and Matter, Indiana University, Bloomington, IN 47403 (United States)

    2016-06-10

    We discuss properties of three-particle Dalitz distributions in coupled channel systems in presence of triangle singularities. The single channel case was discussed long ago [1] where it was found that as a consequence of unitarity, effects of a triangle singularity seen in the Dalitz plot are not seen in Dalitz plot projections. In the coupled channel case we find the same is true for the sum of intensities of all interacting channels. Unlike the single channel case, however, triangle singularities do remain visible in Dalitz plot projections of individual channels.

  10. Development of a heat-stable and orally delivered recombinant M2e-expressing B. subtilis spore-based influenza vaccine.

    Science.gov (United States)

    Zhao, Guangyu; Miao, Yu; Guo, Yan; Qiu, Hongjie; Sun, Shihui; Kou, Zhihua; Yu, Hong; Li, Junfeng; Chen, Yue; Jiang, Shibo; Du, Lanying; Zhou, Yusen

    2014-01-01

    Highly conserved ectodomain of influenza virus M2 protein (M2e) is an important target for the development of universal influenza vaccines. Today, the use of chemical or genetic fusion constructs have been undertaken to overcome the low immunogenicity of M2e in vaccine formulation. However, current M2e vaccines are neither orally delivered nor heat-stable. In this study, we evaluated the immune efficacy of an orally delivered recombinant M2e vaccine containing 3 molcules of M2e consensus sequence of influenza A viruses, termed RSM2e3. To accomplish this, CotB, a spore coat of Bacillus subtilis (B. subtilis), was used as a fusion partner, and heat-stable nonpathogenic B. subtilis spores were used as the carrier. Our results showed that CotB-M2e3 fusion had no effect on spore structure or function in the resultant recombinant RSM2e3 strain and that heterologous influenza virus M2e protein was successfully displayed on the surface of the recombinant RSM2e3 spore. Importantly, recombinant RSM2e3 spores elicited strong and long-term M2e-specific systemic and mucosal immune responses, completely protecting immunized mice from lethal challenge of A/PR/8/34(H1N1) influenza virus. Taken together, our study forms a solid basis for the development of a novel orally delivered and heat-stable influenza vaccine based on B. subtilis spore surface display.

  11. Vegetation-plot data and databases in Europe: an overview

    NARCIS (Netherlands)

    Schaminée, J.H.J.; Hennekens, S.M.; Chytrý, M.; Rodwell, J.S.

    2009-01-01

    During the last decade many electronic databases of vegetation plots, mainly phytosociological relevés, were established in different European countries. These databases contain information which is extremely valuable for both testing various macroecological hypotheses and for nature conservation

  12. Field Plot Points for Voyageurs National Park Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — A total of 191 vegetation field plot samples were collected at Voyageurs National Park and environs to support vegetation classification development. Teams of...

  13. Casa Grande Ruins National Monument Vegetation Mapping Project - Plot Locations

    Data.gov (United States)

    National Park Service, Department of the Interior — This layer contains spatial information for 25 plots sampled during vegetation mapping and classification efforts at Casa Grande Ruins NM, AZ. Data was collected by...

  14. 2012 Four Square Mile survey plots : Kulm WMD

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Map of survey plots for the annual Four-Square-Mile survey conducted on the Kulm Wetland Management District (WMD) as part of a national effort to annually estimate...

  15. The master plot in the audiovisual narrative. The western case.

    Directory of Open Access Journals (Sweden)

    José Félix GONZÁLEZ SÁNCHEZ

    2015-05-01

    Full Text Available A plot provides us the story that it offers a hyphen and later a film. Plots are limited, however possibilities, argument them that these offer music infinite. At the same time, we can say that all cultures avail themselves of some plots and similar arguments to structure their mythical stories. In addition, United States is the modern nation where better a dialectic relation between the myth and story keeps. At this nation, the significance of the event has been shown and you have gotten free through the myth. We will see through this article how the western is the kind of American cinema what else and better answer for the folkloric traditional story to the cánones, because your plots have been taken directly of the classical legends.

  16. Recurrence plots of sunspots, solar flux and irradiance

    CERN Document Server

    Sparavigna, Amelia

    2008-01-01

    The paper shows the recurrence and cross recurrence plots of three time series, concerning data of the solar activity. The data are the sunspot number and the values of solar radio flux at 10.7 cm and of solar total irradiance, which are known as highly correlated. To compare the series, the radio flux and irradiance values are monthly averaged. Recurrence plots display the oscillating behaviour with remarkable features. Moreover, cross recurrence plots help in identifying time lags between the sunspot number maximum and the maximum of radio or irradiance signals, in circumstances where the data values are highly dispersed. Image processing is useful too, in enhancing the monitoring. An interesting behaviour is displayed by cross recurrence plots of irradiance, which are not symmetric with respect to the line of identity.

  17. Field Plot Points for Wupatki National Monument Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — This spatial dataset in ESRI Coverage format maps field releve plot locations for the vegetation classification and descriptions of the vegetation map at Wupatki...

  18. Analysing spatially extended high-dimensional dynamics by recurrence plots

    Energy Technology Data Exchange (ETDEWEB)

    Marwan, Norbert, E-mail: marwan@pik-potsdam.de [Potsdam Institute for Climate Impact Research, 14412 Potsdam (Germany); Kurths, Jürgen [Potsdam Institute for Climate Impact Research, 14412 Potsdam (Germany); Humboldt Universität zu Berlin, Institut für Physik (Germany); Nizhny Novgorod State University, Department of Control Theory, Nizhny Novgorod (Russian Federation); Foerster, Saskia [GFZ German Research Centre for Geosciences, Section 1.4 Remote Sensing, Telegrafenberg, 14473 Potsdam (Germany)

    2015-05-08

    Recurrence plot based measures of complexity are capable tools for characterizing complex dynamics. In this letter we show the potential of selected recurrence plot measures for the investigation of even high-dimensional dynamics. We apply this method on spatially extended chaos, such as derived from the Lorenz96 model and show that the recurrence plot based measures can qualitatively characterize typical dynamical properties such as chaotic or periodic dynamics. Moreover, we demonstrate its power by analysing satellite image time series of vegetation cover with contrasting dynamics as a spatially extended and potentially high-dimensional example from the real world. - Highlights: • We use recurrence plots for analysing partially extended dynamics. • We investigate the high-dimensional chaos of the Lorenz96 model. • The approach distinguishes different spatio-temporal dynamics. • We use the method for studying vegetation cover time series.

  19. A framework for plot control in interactive story systems

    Energy Technology Data Exchange (ETDEWEB)

    Sgouros, N.M.; Papakonstantinou, G.; Tsanakas, P. [National Technical Univ. of Athens, Zographou Campus (Greece)

    1996-12-31

    This paper presents a framework for plot control in interactive story systems. In this framework, the user takes the place of the main character of the story, the protagonist. The rest of the cast consists of discrete characters, each playing a specific role in the story. A separate module in this system, the plot manager, controls the behavior of the cast and specifies what the protagonist can do. The story plot is dynamically shaped by the interference between cast members and their social interactions. The system accepts as input a story map which provides the main metaphor for organizing the plot and localizes the interaction of the protagonist with the rest of the cast. We are implementing this framework in PEGASUS, an interactive travel story environment for Greek mythology.

  20. Graphical interpretation of confidence curves in rankit plots

    DEFF Research Database (Denmark)

    Hyltoft Petersen, Per; Blaabjerg, Ole; Andersen, Marianne

    2004-01-01

    A well-known transformation from the bell-shaped Gaussian (normal) curve to a straight line in the rankit plot is investigated, and a tool for evaluation of the distribution of reference groups is presented. It is based on the confidence intervals for percentiles of the calculated Gaussian...... distribution and the percentage of cumulative points exceeding these limits. The process is to rank the reference values and plot the cumulative frequency points in a rankit plot with a logarithmic (In=log(e)) transformed abscissa. If the distribution is close to In-Gaussian the cumulative frequency points...... presentation, however, makes it easy to disclose deviations from In-Gaussianity, and to make other interpretations of the distributions, e.g., comparison to non-Gaussian distributions in the same plot, where the cumulative frequency percentage can be read from the ordinate. A long list of examples of In...

  1. China's largest tropical rainforest dynamics plot established in Yunnan

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ A 20-ha Tropical Rainforest Dynamics Plot, located in Xishuangbanna in southwestern Yunnan Province, was recently established by the CAS Xishuangbanna Tropical Botanical Garden (XTBG) and the Xishuangbanna National Nature Reserve Administration recently.

  2. Field Plot Points for Tuzigoot National Monument Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — Vegetation field plots at Tuzigoot NM were visited, described, and documented in a digital database. The database consists of 3 parts - (1)Physical Descriptive Data,...

  3. Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages.

    Science.gov (United States)

    Marengo, Barbara; Bellora, Francesca; Ricciarelli, Roberta; De Ciucis, Chiara; Furfaro, AnnaLisa; Leardi, Riccardo; Colla, Renata; Pacini, Davide; Traverso, Nicola; Moretta, Alessandro; Pronzato, Maria Adelaide; Bottino, Cristina; Domenicotti, Cinzia

    2016-01-01

    Macrophages play a crucial role in atherosclerosis progression. Classically activated M1 macrophages have been found in rupture-prone atherosclerotic plaques whereas alternatively activated macrophages, M2, localize in stable plaque. Macrophage accumulation of cholesterol and of its oxidized derivatives (oxysterols) leads to the formation of foam cells, a hallmark of atherosclerotic lesions. In this study, the effects of oxysterols in determining the functional polarization of human macrophages were investigated. Monocytes, purified from peripheral blood mononuclear cells of healthy donors, were differentiated into macrophages (M0) and treated with an oxysterol mixture, cholesterol, or ethanol, every 4 H for a total of 4, 8, and 12 H. The administration of the compounds was repeated in order to maintain the levels of oxysterols constant throughout the treatment. Compared with ethanol treatment, the oxysterol mixture decreased the surface expression of CD36 and CD204 scavenger receptors and reduced the amount of reactive oxygen species whereas it did not affect either cell viability or matrix metalloprotease-9 activity. Moreover, the oxysterol mixture increased the expression of both liver X receptor α and ATP-binding cassette transporter 1. An enhanced secretion of the immunoregulatory cytokine IL-10 accompanied these events. The results supported the hypothesis that the constant levels of oxysterols and, in particular, of 27-hydroxycholesterol stimulate macrophage polarization toward the M2 immunomodulatory functional phenotype, contributing to the stabilization of atherosclerotic plaques.

  4. Plotting partial correlation and regression in ecological studies

    Directory of Open Access Journals (Sweden)

    J. Moya-Laraño

    2008-06-01

    Full Text Available Multiple regression, the General linear model (GLM and the Generalized linear model (GLZ are widely used in ecology. The widespread use of graphs that include fitted regression lines to document patterns in simple linear regression can be easily extended to these multivariate techniques in plots that show the partial relationship of the dependent variable with each independent variable. However, the latter procedure is not nearly as widely used in ecological studies. In fact, a brief review of the recent ecological literature showed that in ca. 20% of the papers the results of multiple regression are displayed by plotting the dependent variable against the raw values of the independent variable. This latter procedure may be misleading because the value of the partial slope may change in magnitude and even in sign relative to the slope obtained in simple least-squares regression. Plots of partial relationships should be used in these situations. Using numerical simulations and real data we show how displaying plots of partial relationships may also be useful for: 1 visualizing the true scatter of points around the partial regression line, and 2 identifying influential observations and non-linear patterns more efficiently than using plots of residuals vs. fitted values. With the aim to help in the assessment of data quality, we show how partial residual plots (residuals from overall model + predicted values from the explanatory variable vs. the explanatory variable should only be used in restricted situations, and how partial regression plots (residuals of Y on the remaining explanatory variables vs. residuals of the target explanatory variable on the remaining explanatory variables should be the ones displayed in publications because they accurately reflect the scatter of partial correlations. Similarly, these partial plots can be applied to visualize the effect of continuous variables in GLM and GLZ for normal distributions and identity link

  5. The Ramachandran plots of glycine and pre-proline

    Directory of Open Access Journals (Sweden)

    Brasseur Robert

    2005-08-01

    Full Text Available Abstract Background The Ramachandran plot is a fundamental tool in the analysis of protein structures. Of the 4 basic types of Ramachandran plots, the interactions that determine the generic and proline Ramachandran plots are well understood. The interactions of the glycine and pre-proline Ramachandran plots are not. Results In glycine, the ψ angle is typically clustered at ψ = 180° and ψ = 0°. We show that these clusters correspond to conformations where either the Ni+1 or O atom is sandwiched between the two Hα atoms of glycine. We show that the shape of the 5 distinct regions of density (the α, αL, βS, βP and βPR regions can be reproduced with electrostatic dipole-dipole interactions. In pre-proline, we analyse the origin of the ζ region of the Ramachandran plot, a region unique to pre-proline. We show that it is stabilized by a COi-1···CδHδi+1 weak hydrogen bond. This is analogous to the COi-1···NHi+1 hydrogen bond that stabilizes the γ region in the generic Ramachandran plot. Conclusion We have identified the specific interactions that affect the backbone of glycine and pre-proline. Knowledge of these interactions will improve current force-fields, and help understand structural motifs containing these residues.

  6. Reviewing ChIPS, The Chandra Imaging and Plotting System

    Science.gov (United States)

    Miller, J.; Burke, D. J.; Evans, I. N.; Evans, J. D.; McLaughlin, W.

    2015-09-01

    The Chandra Imaging and Plotting System (ChIPS) is a 2D plotting system designed to allow users to easily create, manipulate, and produce publication quality visualizations. ChIPS has a simple but very powerful interactive interface that allows users to dynamically modify the contents and layout of their plots quickly and efficiently, with the results of any changes being immediately visible. ChIPS allows users to construct their plots fully interactively, and then save the final plot commands as a Python script. This bypasses the need to iteratively edit and rerun the script when developing the plot. Features such as undo and redo commands allow users to easily step backwards and forwards through previous commands, while the ability so save ChIPS sessions in a platform-independent state file allows the session to be restored at any time, even on another machine. Because ChIPS offers a Python interface, users can analyze their data using the broad array of modules offered in Python, and visualize the information in ChIPS at the same time. In this paper we explore the design decisions behind the development of ChIPS and some of the lessons learned along the way.

  7. The structure of the third intracellular loop of the muscarinic acetylcholine receptor M2 subtype.

    Science.gov (United States)

    Ichiyama, Susumu; Oka, Yoshiaki; Haga, Kazuko; Kojima, Shuichi; Tateishi, Yukihiro; Shirakawa, Masahiro; Haga, Tatsuya

    2006-01-09

    We have examined whether the long third intracellular loop (i3) of the muscarinic acetylcholine receptor M2 subtype has a rigid structure. Circular dichroism (CD) and nuclear magnetic resonance spectra of M2i3 expressed in and purified from Escherichia coli indicated that M2i3 consists mostly of random coil. In addition, the differential CD spectrum between the M2 and M2deltai3 receptors, the latter of which lacks most of i3 except N- and C-terminal ends, gave no indication of secondary structure. These results suggest that the central part of i3 of the M2 receptor has a flexible structure.

  8. Dale Reed with model in front of M2-F1

    Science.gov (United States)

    1967-01-01

    Briegleb Glider Company. The budget was $30,000. NASA craftsmen and engineers built the tubular steel interior frame. Its mahogany plywood shell was hand-made by Gus Briegleb and company. Ernie Lowder, a NASA craftsman who had worked on the Howard Hughes 'Spruce Goose,' was assigned to help Briegleb. The prototype of a 21st Century spacecraft required the fabrication of hundreds of small wooden parts meticulously nailed and glued together. It was a product of craftsmanship that was nearly obsolete in the 1940s. Final assembly of the remaining components (including aluminum tail surfaces, push rod controls, and landing gear from a Cessna 150) was done back at the NASA facility. In the meantime, other NASA engineers devised a special M2-F1 flight simulator, and a hot rod shop near Long Beach souped-up a Pontiac convertible to be used as the lifting body ground-tow vehicle. The M2-F1 did not have ailerons. Instead, it had elevons which were attached to each of the two rudders. A large flap on the trailing edge of the body acted as an elevator. This unconventional arrangement prompted the engineers to rethink the flight control system as well. They eventually devised two schemes. One system was fairly traditional. It used rudder pedal inputs to move the rudders for yaw control, and stick inputs to provide differential deflections of the elevons for roll. The other system used stick inputs to control the rudders for yaw, while rudder pedal deflections moved the elevons for roll. Milt Thompson tried both systems in the simulator and surprised the design team when he said he preferred system number two. He reasoned that although sideslip delayed roll (which was a result of dihedral effect), the roll rate was twice as high using the rudders instead of the elevons. He said he would rather have the higher roll rates available to him if needed, while the slip could be overcome with proper piloting technique. This was the system that Thompson practiced on the simulator, and he used it

  9. Tracking Changes in Cardiac Output: Statistical Considerations on the 4-Quadrant Plot and the Polar Plot Methodology

    National Research Council Canada - National Science Library

    Saugel, Bernd; Grothe, Oliver; Wagner, Julia Y

    2015-01-01

    When comparing 2 technologies for measuring hemodynamic parameters with regard to their ability to track changes, 2 graphical tools are omnipresent in the literaturethe 4-quadrant plot and the polar...

  10. Variability in soil micronutrients extracted by DTPA and Mehlich-3 at the plot scale in an acidic environment

    Science.gov (United States)

    Paz-Ferreiro, Jorge; Lado, Marcos; de Abreu, Cleide A.

    2014-05-01

    Land use practices affect soil properties and nutrient supply. Very limited data are available on micronutrient extractability in northwest Spain. The aim of this study was to analyse long-term effects of land use on the concentration, variability and spatial distribution of soil nutrients. To this end, neighboring forest and cultivated stands were compared. The study was carried out in an acid, rich in organic matter soil developed over sediments at the province of Lugo, northwestern of Spain. Adjacent plots with a surface of 100 m2 were marked on regular square grids with 2-m spacing. Fe, Mn, Zn and Cu were extracted both by Mehlich-3 and DTPA solutions and determined by ICP-MS. General soil chemical and physical properties were routinely analyzed. In arable land, microelement concentration ranges were as follows: Fe (100 and 135 mg kg-1), Mn (7.6 and 21.5 mg kg-1), Zn (0.6 and 3.7 mg kg-1), and Cu (0.2 and 0.7 mg kg-1). In forest land, these ranges were: Fe (62 and 309 mg kg-1), Mn (0.2 and 2.1 mg kg-1), Zn (0.2 and 2.9 mg kg-1), and Cu (0.1 and 0.2 mg kg-1). With the exception of Fe-DTPA, microelement concentrations extracted both with DTPA and Mehlich-3 were higher in the cultivated than in the forest stand. Coefficients of variation were higher for the microelement content of the soil under forest. Principal component analysis was performed to evaluate associations between extractable microelements and general physico-chemical properties. At the studied scale, nutrient management was the main factor affecting the agricultural site, whereas soil-plant interactions were probably responsible for the higher variation within the forest site. Patterns of spatial variability of the studied nutrients at the small plot scale also were assessed by geostatistical techniques. Results were discussed in the frame of sustainable land use and organic matter decline with conventional tillage and sustainable land use

  11. M2M在3GPP SA2的研究进展%The Progress of M2M in 3GPP SA2

    Institute of Scientific and Technical Information of China (English)

    杜加懂

    2011-01-01

    With the rapid development of Internet of things,almost all communication standardization organizations put their focus on the standards of M2M.3GPP as the main mobile communication SDO is working hard on research and standards on M2M.Based on the brief introduction of the 3GPP working groups on M2M,this paper mainly introduces the 3GPP SA2 research progress and standardization on M2M.%随着物联网的快速发展,M2M成为各个标准化组织研究和标准制定的工作重点。3GPP作为移动通信技术的主要研究和标准制定者,对M2M的相关研究和标准制定也在加紧进行。本文在介绍3GPP各个工作组的工作情况的基础上,重点介绍了M2M在3GPP在SA2的研究和标准化进展情况。

  12. A new instrument to measure plot-scale runoff

    Directory of Open Access Journals (Sweden)

    R. D. Stewart

    2014-11-01

    Full Text Available Accurate measurement of the amount and timing of surface runoff at multiple scales is needed to understand fundamental hydrological processes. At the plot-scale (i.e., length scales on the order of 1 to 10 m current methods for direct measurement of runoff either store the water in a collection vessel, which is unconducive to long-term monitoring studies, or utilize expensive installations such as large-scale tipping buckets or flume/weir systems. We developed an alternative low-cost, robust and reliable instrument to measure runoff that we call the "Upwelling Bernoulli Tube" (UBeTube. The UBeTube instrument is a pipe with a slot machined in its side that is installed vertically at the base of a runoff collection system. The flow rate through the slot is inferred by measuring the water height within the pipe. The geometry of the slot can be modified to suit the range of flow rates expected for a given site; we demonstrate a slot geometry which is capable of measuring flow rates across more than three orders of magnitude (up to 300 L min−1 while requiring only 30 cm of hydraulic head. System accuracy is dependent on both the geometry of the slot and the accuracy of the water level measurements. With an off-the-shelf pressure transducer sensor, the mean theoretical error for the demonstrated slot geometry was ~17% (ranging from errors of more than 50% at low flow rates to less than 2% at high flow rates, while the observed error during validation was 1–25%. A simple correction factor reduced this mean error to −14%, and further reductions in error could be achieved through the use of taller, narrower slot dimensions (which requires greater head gradients to drive flow or through more accurate water level measurements. The UBeTube device has been successfully employed in a long-term rainfall-runoff study, demonstrating the ability of the instrument to measure surface runoff across a range of flows and conditions.

  13. File list: ALL.Myo.50.AllAg.LHCN-M2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Myo.50.AllAg.LHCN-M2 hg19 All antigens Muscle LHCN-M2 SRX201296,SRX201297,SRX19...3596,SRX193611,SRX201281,SRX201282 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Myo.50.AllAg.LHCN-M2.bed ...

  14. File list: DNS.Myo.10.AllAg.LHCN-M2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Myo.10.AllAg.LHCN-M2 hg19 DNase-seq Muscle LHCN-M2 SRX201296,SRX201297,SRX19359...6,SRX201281,SRX193611,SRX201282 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.Myo.10.AllAg.LHCN-M2.bed ...

  15. File list: ALL.Myo.05.AllAg.LHCN-M2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Myo.05.AllAg.LHCN-M2 hg19 All antigens Muscle LHCN-M2 SRX201296,SRX201297,SRX19...3596,SRX201281,SRX193611,SRX201282 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Myo.05.AllAg.LHCN-M2.bed ...

  16. File list: DNS.Myo.50.AllAg.LHCN-M2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Myo.50.AllAg.LHCN-M2 hg19 DNase-seq Muscle LHCN-M2 SRX201296,SRX201297,SRX19359...6,SRX193611,SRX201281,SRX201282 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.Myo.50.AllAg.LHCN-M2.bed ...

  17. File list: ALL.Myo.10.AllAg.LHCN-M2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Myo.10.AllAg.LHCN-M2 hg19 All antigens Muscle LHCN-M2 SRX201296,SRX201297,SRX19...3596,SRX201281,SRX193611,SRX201282 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Myo.10.AllAg.LHCN-M2.bed ...

  18. File list: ALL.Myo.20.AllAg.LHCN-M2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Myo.20.AllAg.LHCN-M2 hg19 All antigens Muscle LHCN-M2 SRX201296,SRX201297,SRX19...3596,SRX201281,SRX193611,SRX201282 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Myo.20.AllAg.LHCN-M2.bed ...

  19. File list: DNS.Myo.20.AllAg.LHCN-M2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Myo.20.AllAg.LHCN-M2 hg19 DNase-seq Muscle LHCN-M2 SRX201296,SRX201297,SRX19359...6,SRX201281,SRX193611,SRX201282 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.Myo.20.AllAg.LHCN-M2.bed ...

  20. PPARγ ligands switched high fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination.

    Directory of Open Access Journals (Sweden)

    Lise Lefèvre

    Full Text Available Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI candidiasis is common. We recently demonstrated that the PPARγ ligand rosiglitazone promotes the clearance of Candida albicans through the activation of alternative M2 macrophage polarization. Here, we evaluated the impact of high fat diet (HFD-induced obesity and the effect of rosiglitazone (PPARγ ligand or WY14643 (PPARα ligand both on the phenotypic M1/M2 polarization of peritoneal and cecal tissue macrophages and on the outcome of GI candidiasis. We demonstrated that the peritoneal macrophages and the cell types present in the cecal tissue from HF fed mice present a M2b polarization (TNF-α(high, IL-10(high, MR, Dectin-1. Interestingly, rosiglitazone induces a phenotypic M2b-to-M2a (TNF-α(low, IL-10(low, MR(high, Dectin-1(high switch of peritoneal macrophages and of the cells present in the cecal tissue. The incapacity of WY14643 to switch this polarization toward M2a state, strongly suggests the specific involvement of PPARγ in this mechanism. We showed that in insulin resistant mice, M2b polarization of macrophages present on the site of infection is associated with an increased susceptibility to GI candidiasis, whereas M2a polarization after rosiglitazone treatment favours the GI fungal elimination independently of reduced blood glucose. In conclusion, our data demonstrate a dual benefit of PPARγ ligands because they promote mucosal defence mechanisms against GI candidiasis through M2a macrophage polarization while regulating blood glucose level.

  1. Atrial fibrillation detection by heart rate variability in Poincare plot

    Directory of Open Access Journals (Sweden)

    Jeon Moongu

    2009-12-01

    Full Text Available Abstract Background Atrial fibrillation (AFib is one of the prominent causes of stroke, and its risk increases with age. We need to detect AFib correctly as early as possible to avoid medical disaster because it is likely to proceed into a more serious form in short time. If we can make a portable AFib monitoring system, it will be helpful to many old people because we cannot predict when a patient will have a spasm of AFib. Methods We analyzed heart beat variability from inter-beat intervals obtained by a wavelet-based detector. We made a Poincare plot using the inter-beat intervals. By analyzing the plot, we extracted three feature measures characterizing AFib and non-AFib: the number of clusters, mean stepping increment of inter-beat intervals, and dispersion of the points around a diagonal line in the plot. We divided distribution of the number of clusters into two and calculated mean value of the lower part by k-means clustering method. We classified data whose number of clusters is more than one and less than this mean value as non-AFib data. In the other case, we tried to discriminate AFib from non-AFib using support vector machine with the other feature measures: the mean stepping increment and dispersion of the points in the Poincare plot. Results We found that Poincare plot from non-AFib data showed some pattern, while the plot from AFib data showed irregularly irregular shape. In case of non-AFib data, the definite pattern in the plot manifested itself with some limited number of clusters or closely packed one cluster. In case of AFib data, the number of clusters in the plot was one or too many. We evaluated the accuracy using leave-one-out cross-validation. Mean sensitivity and mean specificity were 91.4% and 92.9% respectively. Conclusions Because pulse beats of ventricles are less likely to be influenced by baseline wandering and noise, we used the inter-beat intervals to diagnose AFib. We visually displayed regularity of the inter

  2. Spatial and temporal variability of throughfall at the plot scale in the Italian pre-Alps

    Science.gov (United States)

    Zuecco, Giulia; Oliviero, Omar; Penna, Daniele; van Meerveld, Ilja; Hopp, Luisa; Dalla Fontana, Giancarlo; Borga, Marco

    2014-05-01

    The redistribution of rainfall in the forest canopy affects many hydrological and biogeochemical processes. Although many studies have focused on the quantification of throughfall, the controls on the spatial variability and temporal persistence of throughfall patterns are still poorly understood. This study therefore aims to: i) quantify throughfall at the plot scale for a pre-Alpine forested hillslope in Italy; ii) assess measurement differences between two different throughfall collectors; and iii) investigate the spatial and temporal variability of throughfall patterns and their relation to canopy characteristics. Throughfall measurements were taken from April to November 2013 in a 500 m2 experimental plot on the hillslope of a small and densely forested catchment (Ressi) in the Italian pre-Alps. The main tree species in the plot are beech and chestnut. The median Diameter at Breast Height of the trees in the plot is 4 cm (range 1-61 cm). Two different rainfall collectors were used: buckets (collecting area: 556 cm2; capacity: 162 mm) and rain gauges (collecting area: 47 cm2; capacity: 80 mm). Fifty buckets were randomly distributed in the plot, while 40 rain gauges were installed on a regular grid (spacing 2.5x3 m). One bucket and one rain gauge collected rainfall in a nearby open area. A tipping bucket rain gauge was installed in the open area as well. Rainfall and throughfall were measured for 20 events by manually emptying the collectors and measuring the volume of water in the collectors. Canopy openness was determined by taking pictures with a 24 mm lens upward from each sampler and selecting thresholds between dark (canopy) and light (sky) areas. For the measured events, rainfall in the open area ranged from 4 mm to 122 mm. Plot-average throughfall for these events ranged between 69%-94% and 68%-100% of precipitation for the buckets and rain gauges, respectively. Throughfall measured by the two types of samplers was statistically similar (Mann

  3. Definition and measurement of the beam propagation factor M2 for chromatic laser beams

    Institute of Scientific and Technical Information of China (English)

    Tao Fang; Xin Ye; Jinfu Niu; Jianqiu Xu

    2006-01-01

    The concept of the beam propagation factor M2 is extended for chromatic laser beams. The definition of the beam propagation factor can be generalized with the weighted effective wavelength. Using the new definition of factor M2, the propagation of chromatic beams can be analyzed by the beam propagation factor M2 as same as that of monochromatic beams. A simple method to measure the chromatic beam factor M2 is demonstrated. The chromatic factor M2 is found invariable while the laser beam propagates through the dispersion-free ABCD system.

  4. Split-plot Experiments with Unusual Numbers of Subplot Runs

    DEFF Research Database (Denmark)

    Kulahci, Murat

    2007-01-01

    In many experimental situations, it may not be feasible or even possible to run experiments in a completely randomized fashion as usually recommended. Under these circumstances, split-plot experiments in which certain factors are changed less frequently than the others are often used. Most...... of the literature on split-plot designs is based on 2-level factorials. For those designs, the number of subplots is a power of 2. There may however be some situations where for cost purposes or physical constraints, we may need to have unusual number of subplots such as 3, 5, 6, etc. In this article, we explore...... this issue and provide some examples based on the Plackett and Burman designs. Also algorithmically constructed D-optimal split-plot designs are compared to those based on Plackett and Burman designs....

  5. D.3.3 PLOT Persuasive Learning Design Framework

    DEFF Research Database (Denmark)

    Gram-Hansen, Sandra Burri

    2012-01-01

    In this third and final deliverable of WP3: Persuasive Learning Designs, the theoretical cross field between persuasion and learning and the practical analysis of the technological learning tools and products which are currently related to the PLOT project, namely the GLOMaker and the 3ET tool......, are linked together as persuasive learning designs are defined and exemplified through the four e-PLOT cases. Based on the literary study of D.3.1 as well as the subsequent discussions and reflections regarding the theoretical foundation and practical application of persuasive learning technologies......, and in acknowledgement that the results of this deliverable are to be applicable in both WP4 and 5, the persuasive learning designs presented in this report are not summarized as patterns. Instead the definition of persuasive learning designs is presented on more general terms and exemplified in relation to the e-PLOT...

  6. Cross recurrence plot based synchronization of time series

    Directory of Open Access Journals (Sweden)

    N. Marwan

    2002-01-01

    Full Text Available The method of recurrence plots is extended to the cross recurrence plots (CRP which, among others, enables the study of synchronization or time differences in two time series. This is emphasized in a distorted main diagonal in the cross recurrence plot, the line of synchronization (LOS. A non-parametrical fit of this LOS can be used to rescale the time axis of the two data series (whereby one of them is compressed or stretched so that they are synchronized. An application of this method to geophysical sediment core data illustrates its suitability for real data. The rock magnetic data of two different sediment cores from the Makarov Basin can be adjusted to each other by using this method, so that they are comparable.

  7. Cross Recurrence Plot Based Synchronization of Time Series

    CERN Document Server

    Marwan, N; Nowaczyk, N R

    2002-01-01

    The method of recurrence plots is extended to the cross recurrence plots (CRP), which among others enables the study of synchronization or time differences in two time series. This is emphasized in a distorted main diagonal in the cross recurrence plot, the line of synchronization (LOS). A non-parametrical fit of this LOS can be used to rescale the time axis of the two data series (whereby one of it is e.g. compressed or stretched) so that they are synchronized. An application of this method to geophysical sediment core data illustrates its suitability for real data. The rock magnetic data of two different sediment cores from the Makarov Basin can be adjusted to each other by using this method, so that they are comparable.

  8. Experts’ Misinterpretation of Box Plots – a Dual Processing Approach

    Directory of Open Access Journals (Sweden)

    Stephanie Lem

    2014-11-01

    Full Text Available Recent studies have shown that students often misinterpret the area of the box in box plots as representing the frequency or proportion of observations in that interval, while it actually represents density. This misinterpretation has been shown to be based on the saliency of this area and can be explained by heuristic reasoning as defined by dual process theories. In this study we tested whether expert users of box plots also display this misinterpretation and show signs of the same heuristic reasoning as found in students. Using a reaction time test, we found signs of heuristic reasoning in experts, both with respect to accuracy and reaction times. If even experts have difficulty interpreting box plots, one can question whether these are an appropriate form of representation to use when reporting data and deserve the prominent place they currently have in the statistics curriculum.

  9. Effects of bimetallic doping on small cyclic and tubular boron clusters: B7M2 and B14M2 structures with M = Fe, Co.

    Science.gov (United States)

    Pham, Hung Tan; Nguyen, Minh Tho

    2015-07-14

    Using density functional theory with the TPSSh functional and the 6-311+G(d) basis set, we extensively searched for the global minima of two metallic atoms doped boron clusters B6M2, B7M2, B12M2 and B14M2 with transition metal element M being Co and Fe. Structural identifications reveal that B7Co2, B7Fe2 and B7CoFe clusters have global minima in a B-cyclic motif, in which a perfectly planar B7 is coordinated with two metallic atoms placed along the C7 axis. The B6 cluster is too small to form a cycle with the presence of two metals. Similarly, the B12 cluster is not large enough to stabilize the metallic dimer within a double ring 2 × B6 tube. The doped B14M2 clusters including B14Co2, B14Fe2 and B14CoFe have a double ring 2 × B7 tubular shape in which one metal atom is encapsulated by the B14 tube and the other is located at an exposed position. Dissociation energies demonstrate that while bimetallic cyclic cluster B7M2 prefers a fragmentation channel that generates the B7 global minimum plus metallic dimer, the tubular structure B14M2 tends to dissociate giving a bimetallic cyclic structure B7M2 and a B@B6 cluster. The enhanced stability of the bimetallic doped boron clusters considered can be understood from the stabilizing interactions between the anti-bonding MOs of metal-metal dimers and the levels of a disk aromatic configuration (for bimetallic cyclic structures), or the eigenstates of the B14 tubular form (in case of bimetallic tubular structure).

  10. Design criteria and eigensequence plots for satellite computed tomography

    Science.gov (United States)

    Wahba, G.

    1983-01-01

    The use of the degrees of freedom for signal is proposed as a design criteria for comparing different designs for satellite and other measuring systems. It is also proposed that certain eigensequence plots be examined at the design stage along with appropriate estimates of the parameter lambda playing the role of noise to signal ratio. The degrees of freedom for signal and the eigensequence plots may be determined using prior information in the spectral domain which is presently available along with a description of the system, and simulated data for estimating lambda. This work extends the 1972 work of Weinreb and Crosby.

  11. D.3.2 PLOT Persuasive Learning Design Framework

    DEFF Research Database (Denmark)

    Gram-Hansen, Sandra Burri; Schärfe, Henrik; Winther-Nielsen, Nicolai

    2011-01-01

    of the technological learning tools and products which are currently related to the PLOT project, namely the GLOMaker and the 3ET tool, and a selection of GLOs and learning exercises. The primary focus of the analysis is to explore how the theoretical perspectives presented in D.3.1 are represented in these tools......, in particular the notions of persuasive design and constructive alignment. Whilst the report provides a persuasive design perspective on the technologies related to Euro PLOT, it must be stressed that if the document is to function as a basis for further discussion within the consortium, the partners...

  12. [Recurrence plot analysis of HRV for brain ischemia and asphyxia].

    Science.gov (United States)

    Chen, Xiaoming; Qiu, Yihong; Zhu, Yisheng

    2008-02-01

    Heart rate variability (HRV) is the tiny variability existing in the cycles of the heart beats, which reflects the corresponding balance between sympathetic and vagus nerves. Since the nonlinear characteristic of HRV is confirmed, the Recurrence Plot method, a nonlinear dynamic analysis method based on the complexity, could be used to analyze HRV. The results showed the recurrence plot structures and some quantitative indices (L-Mean, L-Entr) during asphyxia insult vary significantly as compared to those in normal conditions, which offer a new method to monitor brain asphyxia injury.

  13. Recurrence plots and recurrence quantification analysis of human motion data

    Science.gov (United States)

    Josiński, Henryk; Michalczuk, Agnieszka; Świtoński, Adam; Szczesna, Agnieszka; Wojciechowski, Konrad

    2016-06-01

    The authors present exemplary application of recurrence plots, cross recurrence plots and recurrence quantification analysis for the purpose of exploration of experimental time series describing selected aspects of human motion. Time series were extracted from treadmill gait sequences which were recorded in the Human Motion Laboratory (HML) of the Polish-Japanese Academy of Information Technology in Bytom, Poland by means of the Vicon system. Analysis was focused on the time series representing movements of hip, knee, ankle and wrist joints in the sagittal plane.

  14. Vector plotting as an indication of the approach to flutter

    Science.gov (United States)

    Broadbent, E. G.

    1975-01-01

    A binary flexure-torsion analysis was made to check theoretically a method for predicting flutter which depends on plotting vectorially the amplitudes of response relative to the exciting force and extracting the relevant damping rate. The results of this calculation are given in graphs both of the vector plots themselves and of the estimated damping rate against forward speed. The estimated damping rates are compared with calculated values. The method has the advantage that in a flight flutter test damping can be estimated from continuous excitation records: the method is an extension of the Kennedy and Pancu technique used in ground resonance testing.

  15. Facilitated gate setting by sequential dot plot scanning.

    Science.gov (United States)

    Günther, Susanne; Müller, Susann

    2015-07-01

    Microbial communities comprising thousands of unknown organisms can be studied flow cytometrically by applying just one fluorescent parameter and using scatter characteristics of cells. Resulting 2D-plots need to represent high numbers of cells to detect the many subcommunities, even rare ones that might be present in the sample. Evaluation of such data can be faulty and subjective due to the low number of parameters available for data discrimination and the high numbers of overlaying events. Here, we describe a procedure that helps to evaluate such data using facilitated gate setting by sequential dot-plot scanning.

  16. On the Nature of Earth-Mars Porkchop Plots

    Science.gov (United States)

    Woolley, Ryan C.; Whetsel, Charles W.

    2013-01-01

    Porkchop plots are a quick and convenient tool to help mission designers plan ballistic trajectories between two bodies. Parameter contours give rise to the familiar 'porkchop' shape. Each synodic period the pattern repeats, but not exactly, primarily due to differences in inclination and non-zero eccentricity. In this paper we examine the morphological features of Earth-to-Mars porkchop plots and the orbital characteristics that create them. These results are compared to idealistic and optimized transfers. Conclusions are drawn about 'good' opportunities versus 'bad' opportunities for different mission applications.

  17. Evaluation of a Smartphone App for Forest Sample Plot Measurements

    OpenAIRE

    Mikko Vastaranta; Eduardo González Latorre; Ville Luoma; Ninni Saarinen; Markus Holopainen; Juha Hyyppä

    2015-01-01

    We evaluated a smartphone app (TRESTIMA(TM)) for forest sample plot measurements. The app interprets imagery collected from the sample plots using the camera in the smartphone and then estimates forest inventory attributes, including species-specific basal areas (G) as well as the diameter (D-gM) and height (H-gM) of basal area median trees. The estimates from the smartphone app were compared to forest inventory attributes derived from tree-wise measurements using calipers and a Vertex height...

  18. On the Nature of Earth-Mars Porkchop Plots

    Science.gov (United States)

    Woolley, Ryan C.; Whetsel, Charles W.

    2013-01-01

    Porkchop plots are a quick and convenient tool to help mission designers plan ballistic trajectories between two bodies. Parameter contours give rise to the familiar 'porkchop' shape. Each synodic period the pattern repeats, but not exactly, primarily due to differences in inclination and non-zero eccentricity. In this paper we examine the morphological features of Earth-to-Mars porkchop plots and the orbital characteristics that create them. These results are compared to idealistic and optimized transfers. Conclusions are drawn about 'good' opportunities versus 'bad' opportunities for different mission applications.

  19. PlotXY: A High Quality Plotting System for the Herschel Interactive Processing Environment (HIPE) and the Astronomical Community

    Science.gov (United States)

    Panuzzo, P.; Li, J.; Caux, E.

    2012-09-01

    The Herschel Interactive Processing Environment (HIPE) was developed by the European Space Agency (ESA) in collaboration with NASA and the Herschel Instrument Control Centres, to provide the astronomical community a complete environment to process and analyze the data gathered by the Herschel Space Observatory. One of the most important components of HIPE is the plotting system (named PlotXY) that we present here. With PlotXY it is possible to produce easily high quality publication-ready 2D plots. It provides a long list of features, with fully configurable components, and interactive zooming. The entire code of HIPE is written in Java and is open source released under the GNU Lesser General Public License version 3. A new version of PlotXY is being developed to be independent from the HIPE code base; it is available to the software development community for the inclusion in other projects at the URL google.com/p/jplot2d/'>http://code.google.com/p/jplot2d/.

  20. Sublingual immunization with M2-based vaccine induces broad protective immunity against influenza.

    Directory of Open Access Journals (Sweden)

    Byoung-Shik Shim

    Full Text Available BACKGROUND: The ectodomain of matrix protein 2 (M2e of influenza A virus is a rationale target antigen candidate for the development of a universal vaccine against influenza as M2e undergoes little sequence variation amongst human influenza A strains. Vaccine-induced M2e-specific antibodies (Abs have been shown to display significant cross-protective activity in animal models. M2e-based vaccine constructs have been shown to be more protective when administered by the intranasal (i.n. route than after parenteral injection. However, i.n. administration of vaccines poses rare but serious safety issues associated with retrograde passage of inhaled antigens and adjuvants through the olfactory epithelium. In this study, we examined whether the sublingual (s.l. route could serve as a safe and effective alternative mucosal delivery route for administering a prototype M2e-based vaccine. The mechanism whereby s.l. immunization with M2e vaccine candidate induces broad protection against infection with different influenza virus subtypes was explored. METHODS AND RESULTS: A recombinant M2 protein with three tandem copies of the M2e (3M2eC was expressed in Escherichia coli. Parenteral immunizations of mice with 3M2eC induced high levels of M2e-specific serum Abs but failed to provide complete protection against lethal challenge with influenza virus. In contrast, s.l. immunization with 3M2eC was superior for inducing protection in mice. In the latter animals, protection was associated with specific Ab responses in the lungs. CONCLUSIONS: The results demonstrate that s.l. immunization with 3M2eC vaccine induced airway mucosal immune responses along with broad cross-protective immunity to influenza. These findings may contribute to the understanding of the M2-based vaccine approach to control epidemic and pandemic influenza infections.

  1. Desensitization of human muscarinic acetylcholine receptor m2 subtypes is caused by their sequestration/internalization.

    Science.gov (United States)

    Tsuga, H; Kameyama, K; Haga, T

    1998-10-01

    Desensitization of human muscarinic acetylcholine receptor m2 subtypes (hm2 receptors) stably expressed in chinese hamster ovary cells was measured as decreases in the carbamylcholine-stimulated [35S]GTPgammaS binding activity in membrane preparations after pre-treatment of cells with carbamylcholine. The extent of carbamylcholine-stimulated [35S]GTPgammaS binding activity was found to decrease to 64% following pretreatment of cells with 10 microM carbamylcholine for 30 min, and under the same conditions 51-59% of hm2 receptors were sequestered/internalized as assessed by decreases in the [3H]N-methylscopolamine binding activity on the cell surface. A similar reduction in the carbamylcholine-stimulated [35S]GTPgammaS binding activity was observed by pretreatment of cells with 5 nM propylbenzylylcholine mustard, which irreversibly bound to and inactivated 58% of the hm2 receptors. When the cells were pretreated with 10 microM carbamylcholine in the presence of 0.32 M sucrose, which is known to inhibit clathrin-mediated endocytosis, no sequestration/internalization of hm2 receptors was observed, and the extent of carbamylcholine-stimulated [35S]GTPgammaS binding activity did not change. These results indicate that desensitization of hm2 receptors may be caused by reduction of receptor number on the cell surface through sequestration/internalization rather than by loss of the function of receptors.

  2. The fire effect on Cerrado: Analysis of the erosive process associated with native vegetation by the use of experimental plots

    Science.gov (United States)

    Costa, Yasmmin; Rodrigues, Sílvio

    2015-04-01

    In Brazil vast areas of vegetation are devastated each year by the use of fire that recorded more than 200,000 hotspots annually. In this context, the state of Minas Gerais appears first in the number of fires and burned areas due to its long stretch of reforested area in an environment where a prolonged dry season contributes to the occurrence and spread of fire in the Cerrado vegetation. This research consists of a comparative study through the controlled application of fire under different conditions of natural vegetation of the focusing on the change in rates of runoff, sediment production and vegetation density in order to evaluate the influence of burning related to soil erosion. The area of study is located in Uberlândia at an altitude of 850 meters above sea level and in the respective geographic coordinates 18°56'56"S and 48°12'21"W that composes the watershed of Glória stream. The climate is characterized by dry winters and rainy summer. On this area five experimental plots was established from the specific characteristic of its vegetation cover, slope and drainage, thus differentiated: well drained soil with the presence of a dense grass (plot A), well drained soil with the presence of shrub and grasses (plot B), poorly drained with a non-dense grass (plot C), well drained soil with grass (plot D), and well drained with grasses and tree cover(plot E). The plots have 1m2 that is connected with a trough collector that concentrate the water flow generated by runoff with a 30 liter gallon that was weekly measured. The data relating to runoff and sediment yield were obtained from the collection of water derived from water stored in gallons, in which first was homogenized, measured quantity and collected 1 liter of water to be filtrated in the laboratory. The analysis method of vegetation density was performed based on the methodology proposed by Pinese Junior, Cruz and Rodrigues (2008), using the software ENVI 4.3 to interpret and quantify the image

  3. Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein.

    Directory of Open Access Journals (Sweden)

    Anne-Marie Carola Andersson

    Full Text Available The ectodomain of the matrix 2 protein (M2e of influenza A virus represents an attractive target for developing a universal influenza A vaccine, with its sequence being highly conserved amongst human variants of this virus. With the aim of targeting conformational epitopes presumably shared by diverse influenza A viruses, a vaccine (M2e-NSP4 was constructed linking M2e (in its consensus sequence to the rotavirus fragment NSP4(98-135; due to its coiled-coil region this fragment is known to form tetramers in aqueous solution and in this manner we hoped to mimick the natural configuration of M2e as presented in membranes. M2e-NSP4 was then evaluated side-by-side with synthetic M2e peptide for its immunogenicity and protective efficacy in a murine influenza challenge model. Here we demonstrate that M2e fused to the tetramerizing protein induces an accelerated, augmented and more broadly reactive antibody response than does M2e peptide as measured in two different assays. Most importantly, vaccination with M2e-NSP4 caused a significant decrease in lung virus load early after challenge with influenza A virus and maintained its efficacy against a lethal challenge even at very low vaccine doses. Based on the results presented in this study M2e-NSP4 merits further investigation as a candidate for or as a component of a universal influenza A vaccine.

  4. Field Plot and Accuracy Assessment Points for Palo Alto Battlefield National Historical Park Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — Accuracy Assessment, Observation and Plot Points. Plot data were collected from 2000-2003; however, minimal attributes were maintained and a plots database was not...

  5. Field Plot and Accuracy Assessment Points for Hagerman Fossil Beds National Monument Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — Accuracy Assessment, Observation and Plot Points. Plot points were created from the GPS coordinates recorded at the center of each plot to map their distribution and...

  6. How useful are Green-Ampt parameters derived from small rainfall simulation plots for modelling runoff at different plot lengths?

    Science.gov (United States)

    Langhans, Christoph; Engels, Lien; Tegenbos, Lize; Govers, Gerard; Diels, Jan

    2010-05-01

    Rainfall simulation on small field plots is an invaluable method to derive effective field parameters for infiltration models such as Green-Ampt. Plot scales of ca. 1m² integrate much of the micro-scale variability and processes, which ring-infiltrometers or soil core measurements cannot capture. However, these parameters have to be used with caution on larger scales, because processes such as run-on infiltration can be considerable. The Green-Ampt parameters suction across the wetting front (psi) and effective hydraulic conductivity (Ke) were estimated from rainfall simulations on two ridged fields in Togo, West Africa. Additionally, rainfall events were recorded, and on plots of 1m width and lengths of 1, 4 and 16m, total runoff volume and sediment concentration were measured. The storm runoff hydrographs of the plots were modelled with Chu's Green-Ampt variable rainfall intensity infiltration model, using the field-average parameters derived from the simulations. Potential effects of runoff lag time were assumed negligible. Calculated total runoff volumes were compared to measured runoff volumes. For the 1m plots, runoff was underestimated, as patches of seal in the furrows produced runoff already at rainfall intensities much lower than the average infiltration capacity. For the longer plots, no run-on infiltration or other scale dependent processes were assumed, so the relative error due to scale effects was proportional to the average difference or runoff depth. In contrast to the 1m plots, runoff was overestimated by a factor of 1.2 and 2 for the 4m and 16m plots, respectively. It appears that the application of the Green-Ampt effective hydraulic conductivity derived from rainfall simulations faces two main problems, which are their dependence on one single rainfall intensity and scale-effects by run-on infiltration. Errors necessarily propagate into the scale dependency of erosion and sediment transport, as these processes are directly dependent on runoff

  7. plotKML: Scientific Visualization of Spatio-Temporal Data

    Directory of Open Access Journals (Sweden)

    Tomislav Hengl

    2015-02-01

    Full Text Available plotKML is an R package that provides methods for writing the most common R spatial classes into KML files. It builds up on the existing XML parsing functionality (XML package, and provides similar plotting functionality as the lattice package. Its main objective is to provide a simple interface to generate KML files with a small number of arguments, and allows users to visually explore spatio-temporal data available in R: points, polygons, gridded maps, trajectory-type data, vertical profiles, ground photographs, time series vector objects or raster images, along with the results of spatial analysis such as geostatistical mapping, spatial simulations of vector and gridded objects, optimized sampling designs, species distribution models and similar. A generic plotKML( function automatically determines the parsing order and visualizes data directly from R; lower level functions can be combined to allow for new user-created visualization templates. In comparison to other packages writing KML, plotKML seems to be more object oriented, it links more closely to the existing R classes for spatio-temporal data (sp, spacetime and raster packages than the alternatives, and provides users with the possibility to create their own templates.

  8. Designing fractional factorial split-plot experiments using integer programming

    DEFF Research Database (Denmark)

    Capehart, Shay R.; Keha, Ahmet; Kulahci, Murat

    2011-01-01

    factorial (FF) design, with the restricted randomisation structure to account for the whole plots and subplots. We discuss the formulation of FFSP designs using integer programming (IP) to achieve various design criteria. We specifically look at the maximum number of clear two-factor interactions...

  9. 70 Years of permanent plot research in The Netherlands

    NARCIS (Netherlands)

    Smits, N.A.C.; Schaminée, J.H.J.; Duuren, van L.

    2002-01-01

    Within the framework of the Dutch `Network Ecological Monitoring¿, a large set of new permanent plots has been established to monitor selected plant communities throughout The Netherlands for studying the effects of environmental changes on species composition of semi-natural communities. This

  10. D.3.1 PLOT Persuasive Learning Design Framework

    DEFF Research Database (Denmark)

    Gram-Hansen, Sandra Burri; Schärfe, Henrik; Dinesen, Jens Vilhelm

    2011-01-01

    , constructive alignment, and towards a common understanding of the ethical stances we believe should underpin persuasive efforts. In section 4, we present viewpoints on the four cases, central to the PLOT project. This section is the result of a workshop held at the consortium meeting in Aalborg. Finally...

  11. Designing fractional factorial split-plot experiments using integer programming

    DEFF Research Database (Denmark)

    Capehart, Shay R.; Keha, Ahmet; Kulahci, Murat

    2011-01-01

    factorial (FF) design, with the restricted randomisation structure to account for the whole plots and subplots. We discuss the formulation of FFSP designs using integer programming (IP) to achieve various design criteria. We specifically look at the maximum number of clear two-factor interactions...

  12. Constructing General Orthogonal Fractional Factorial Split-Plot Designs

    NARCIS (Netherlands)

    Sartono, B.; Goos, P.; Schoen, E.

    2015-01-01

    While the orthogonal design of split-plot fractional factorial experiments has received much attention already, there are still major voids in the literature. First, designs with one or more factors acting at more than two levels have not yet been considered. Second, published work on nonregular fra

  13. Omitted Variable Sensitivity Analysis with the Annotated Love Plot

    Science.gov (United States)

    Hansen, Ben B.; Fredrickson, Mark M.

    2014-01-01

    The goal of this research is to make sensitivity analysis accessible not only to empirical researchers but also to the various stakeholders for whom educational evaluations are conducted. To do this it derives anchors for the omitted variable (OV)-program participation association intrinsically, using the Love plot to present a wide range of…

  14. A Simple Interactive Software Package for Plotting, Animating, and Calculating

    Science.gov (United States)

    Engelhardt, Larry

    2012-01-01

    We introduce a new open source (free) software package that provides a simple, highly interactive interface for carrying out certain mathematical tasks that are commonly encountered in physics. These tasks include plotting and animating functions, solving systems of coupled algebraic equations, and basic calculus (differentiating and integrating…

  15. Subclassifying disordered proteins by the CH-CDF plot method.

    Science.gov (United States)

    Huang, Fei; Oldfield, Christopher; Meng, Jingwei; Hsu, Wei-Lun; Xue, Bin; Uversky, Vladimir N; Romero, Pedro; Dunker, A Keith

    2012-01-01

    Intrinsically disordered proteins (IDPs) are associated with a wide range of functions. We suggest that sequence-based subtypes, which we call flavors, may provide the basis for different biological functions. The problem is to find a method that separates IDPs into different flavor / function groups. Here we discuss one approach, the (Charge-Hydropathy) versus (Cumulative Distribution Function) plot or CH-CDF plot, which is based the combined use of the CH and CDF disorder predictors. These two predictors are based on significantly different inputs and methods. This CH-CDF plot partitions all proteins into 4 groups: structured, mixed, disordered, and rare. Studies of the Protein Data Bank (PDB) entries and homologous show different structural biases for each group classified by the CH-CDF plot. The mixed class has more order-promoting residues and more ordered regions than the disordered class. To test whether this partition accomplishes any functional separation, we performed gene ontology (GO) term analysis on each class. Some functions are indeed found to be related to subtypes of disorder: the disordered class is highly active in mitosis-related processes among others. Meanwhile, the mixed class is highly associated with signaling pathways, where having both ordered and disordered regions could possibly be important.

  16. Developing Box Plots While Navigating the Maze of Data Representations

    Science.gov (United States)

    Duncan, Bruce; Fitzallen, Noleine

    2013-01-01

    The learning sequence described in this article was developed to provide students with a demonstration of the development of box plots from authentic data as an illustration of the advantages gained from using multiple forms of data representation. The sequence follows an authentic process that starts with a problem to which data representations…

  17. Polar plot representation of time-resolved fluorescence.

    Science.gov (United States)

    Eichorst, John Paul; Wen Teng, Kai; Clegg, Robert M

    2014-01-01

    Measuring changes in a molecule's fluorescence emission is a common technique to study complex biological systems such as cells and tissues. Although the steady-state fluorescence intensity is frequently used, measuring the average amount of time that a molecule spends in the excited state (the fluorescence lifetime) reveals more detailed information about its local environment. The lifetime is measured in the time domain by detecting directly the decay of fluorescence following excitation by short pulse of light. The lifetime can also be measured in the frequency domain by recording the phase and amplitude of oscillation in the emitted fluorescence of the sample in response to repetitively modulated excitation light. In either the time or frequency domain, the analysis of data to extract lifetimes can be computationally intensive. For example, a variety of iterative fitting algorithms already exist to determine lifetimes from samples that contain multiple fluorescing species. However, recently a method of analysis referred to as the polar plot (or phasor plot) is a graphical tool that projects the time-dependent features of the sample's fluorescence in either the time or frequency domain into the Cartesian plane to characterize the sample's lifetime. The coordinate transformations of the polar plot require only the raw data, and hence, there are no uncertainties from extensive corrections or time-consuming fitting in this analysis. In this chapter, the history and mathematical background of the polar plot will be presented along with examples that highlight how it can be used in both cuvette-based and imaging applications.

  18. Igloo-Plot: a tool for visualization of multidimensional datasets.

    Science.gov (United States)

    Kuntal, Bhusan K; Ghosh, Tarini Shankar; Mande, Sharmila S

    2014-01-01

    Advances in science and technology have resulted in an exponential growth of multivariate (or multi-dimensional) datasets which are being generated from various research areas especially in the domain of biological sciences. Visualization and analysis of such data (with the objective of uncovering the hidden patterns therein) is an important and challenging task. We present a tool, called Igloo-Plot, for efficient visualization of multidimensional datasets. The tool addresses some of the key limitations of contemporary multivariate visualization and analysis tools. The visualization layout, not only facilitates an easy identification of clusters of data-points having similar feature compositions, but also the 'marker features' specific to each of these clusters. The applicability of the various functionalities implemented herein is demonstrated using several well studied multi-dimensional datasets. Igloo-Plot is expected to be a valuable resource for researchers working in multivariate data mining studies. Igloo-Plot is available for download from: http://metagenomics.atc.tcs.com/IglooPlot/.

  19. Box-and-Whisker Plots Applied to Food Chemistry

    Science.gov (United States)

    Ferreira, Joao E. V.; Miranda, Ricardo M.; Figueiredo, Antonio F.; Barbosa, Jardel P.; Brasil, Edykarlos M.

    2016-01-01

    Box-and-whisker plots or simply boxplots are powerful graphical representations that give an overview of a data set. In this work five different examples illustrate the applications of boxplots in food chemistry. The examples involve relative sweetness of sugars and sugar alcohols with respect to sucrose, the potassium content of fruits and…

  20. Non-parametric and least squares Langley plot methods

    Directory of Open Access Journals (Sweden)

    P. W. Kiedron

    2015-04-01

    Full Text Available Langley plots are used to calibrate sun radiometers primarily for the measurement of the aerosol component of the atmosphere that attenuates (scatters and absorbs incoming direct solar radiation. In principle, the calibration of a sun radiometer is a straightforward application of the Bouguer–Lambert–Beer law V=V>/i>0e−τ ·m, where a plot of ln (V voltage vs. m air mass yields a straight line with intercept ln (V0. This ln (V0 subsequently can be used to solve for τ for any measurement of V and calculation of m. This calibration works well on some high mountain sites, but the application of the Langley plot calibration technique is more complicated at other, more interesting, locales. This paper is concerned with ferreting out calibrations at difficult sites and examining and comparing a number of conventional and non-conventional methods for obtaining successful Langley plots. The eleven techniques discussed indicate that both least squares and various non-parametric techniques produce satisfactory calibrations with no significant differences among them when the time series of ln (V0's are smoothed and interpolated with median and mean moving window filters.

  1. Box-and-Whisker Plots Applied to Food Chemistry

    Science.gov (United States)

    Ferreira, Joao E. V.; Miranda, Ricardo M.; Figueiredo, Antonio F.; Barbosa, Jardel P.; Brasil, Edykarlos M.

    2016-01-01

    Box-and-whisker plots or simply boxplots are powerful graphical representations that give an overview of a data set. In this work five different examples illustrate the applications of boxplots in food chemistry. The examples involve relative sweetness of sugars and sugar alcohols with respect to sucrose, the potassium content of fruits and…

  2. Plot-scale testing and sensitivity analysis of Be7 based soil erosion conversion models

    Science.gov (United States)

    Taylor, Alex; Abdelli, Wahid; Barri, Bashar Al; Iurian, Andra; Gaspar, Leticia; Mabit, Lionel; Millward, Geoff; Ryken, Nick; Blake, Will

    2016-04-01

    Over the past 2 decades, a growing number of studies have recognised the potential for short-lived cosmogenic Be-7 (half-life 53 days) to be used as a tracer to evaluate soil erosion from short-term inter-rill erosion to hillslope sediment budgets. While conversion modelling approaches are now established for event-scale and extended-time-series applications, there is a lack of validation and sensitivity analysis to underpin confidence in their use across a full range of agro-climatic zones. This contribution aims to close this gap in the context of the maritime temperate climate of southwest UK. Two plots of 4 x 35 m were ploughed and tilled at the beginning of winter 2013/2014 in southwest UK to create (1) a bare, sloped soil surface and (2) a bare flat reference site. The bounded lower edge of the plot fed into a collection bin for overland flow and associated sediment. The tilled surface had a low bulk density and high permeability at the start of the experiment (ksat > 100 mm/hr). Hence, despite high rainfall in December (200 mm), notable overland flow was observed only after intense rain storms during late 2013 and early January 2014 when the soil profile was saturated i.e. driven by Saturation Overland Flow (SOF). At the time of SOF initiation, ca. 70% of the final Be-7 inventory had been delivered to the site. Subsequent to a series SOF events across a 1 month period, the plot soil surface was intensively sampled to quantify Be-7 inventory patterns and develop a tracer budget. Captured eroded sediment was dried, weighed and analysed for Be-7. All samples were analysed for particle size by laser granulometry. Be-7 inventory data were converted to soil erosion estimates using (1) standard profile distribution model, (2) the extended time series distribution model and (3) a new 'antecedent rainfall' extended time series model to account for lack of soil erosion prior to soil saturation. Results were scaled up to deliver a plot-scale sediment budget to include

  3. Immunohistochemical localisation of pre-synaptic muscarinic receptor subtype-2 (M2r) in the enteric nervous system of guinea-pig ileum.

    Science.gov (United States)

    Harrington, A M; Hutson, J M; Southwell, B R

    2008-04-01

    The cholinergic muscarinic 2 receptor (M2r) is known to be present on smooth muscle cells in the intestine. Pharmacological studies also suggest that M2rs regulate transmitter release from nerves in the enteric nervous system. This study localised M2rs in the guinea-pig ileum using different antibodies and fluorescence immunohistochemistry. Double labelling with antibodies against neurochemical markers was used to identify the type of nerves bearing M2r. Guinea-pig ileum were fixed, prepared for sections and wholemounts and incubated with antisera against the M2r sequence. Tissue was double labelled with antibodies against neuronal nitric oxide synthase (nNOS), common choline acetyltransferase (cChAT), substance P (SP), synaptophysin and vesicular acetylcholine transporter (VAChT). Immunofluorescence was viewed using confocal microscopy. Abundant M2r-immunoreactivity (IR) was present on the surface of circular and longitudinal smooth muscle cells. M2r-IR was present in many but not all nerve fibres in the circular muscle and ganglia. M2r-IR was present in VAChT-IR and cChAT-IR cholinergic nerve fibres and SP-IR nerve fibres in the myenteric ganglia and submucosal ganglia. M2r-IR was present on a few nNOS-IR nerve fibres and around nNOS-IR neurons in the myenteric ganglia. In the circular muscle and deep muscular plexus, M2r-IR was present in many VAChT-IR and SP-IR nerve fibres and in few nNOS-IR nerves. M2rs are not only present on muscle cells in the intestine, but also on nerve fibres. M2rs may mediate cholinergic reflexes via their location on muscle and also via neural transmission. The pre-synaptic location supports pharmacological studies suggesting M2rs mediate neurotransmitter release from nerve fibres. The presence of M2rs on VAChT-IR, SP-IR and nNOS-IR-containing nerve fibres suggests M2rs may regulate ACh, SP and nitric oxide release.

  4. Comparative water balance study of forest and fallow plots

    Directory of Open Access Journals (Sweden)

    Móricz N

    2012-08-01

    Full Text Available Increasing pressure on groundwater due to land use change (e.g., afforestation and future climate change will alter the recharge of groundwater aquifers, causing shifts in water table levels and hence influencing the avai­lable groundwater resources. The effect of land use change on groundwater resources has initiated a major scientific debate during the last decades between foresters and experts in water management in Hungary and in several other countries. The aim of this study was to compare water balances of two different vegetation covers, a groundwater dependent oak forest and a nearby fallow area in the Hungarian Lowland. Water balance components for an oak and a fallow plots, exposed to similar weather conditions and with similar soils, were estimated and compared by calibrating the Hydrus 1-D model using mea­sured soil water content and groundwater levels. The difference in the groundwater consumption was analyzed in details during dry and wet growing seasons. Transpiration at the fallow plot was only about two-thirds of that in the oak forest, while groundwater consumption was three times higher in the forest than at the fallow plot throughout the two-year study. During the dry growing season, the proportion of groundwater use from the total transpiration reached up to 90% at the oak plot. According to the model, in the dry growing season in 2007 both vegetation covers relied significantly on groundwater resources, while in 2008 the consumption of groundwater was notably reduced due to the wet weather at both plots.

  5. Aquifer test interpretation using derivative analysis and diagnostic plots

    Science.gov (United States)

    Hernández-Espriú, Antonio; Real-Rangel, Roberto; Cortés-Salazar, Iván; Castro-Herrera, Israel; Luna-Izazaga, Gabriela; Sánchez-León, Emilio

    2017-04-01

    Pumping tests remain a method of choice to deduce fundamental aquifer properties and to assess well condition. In the oil and gas (O&G) industry, well testing has been the core technique in examining reservoir behavior over the last 50 years. The pressure derivative by Bourdet, it is perhaps, the most significant single development in the history of well test analysis. Recently, the so-called diagnostics plots (e.g. drawdown and drawdown derivative in a log-log plot) have been successfully tested in aquifers. However, this procedure is still underutilized by groundwater professionals. This research illustrates the applicability range, advantages and drawbacks (e.g. smoothing procedures) of diagnostic plots using field examples from a wide spectrum of tests (short/long tests, constant/variable flow rates, drawdown/buildup stages, pumping well/observation well) in dissimilar geological conditions. We analyze new and pre-existent aquifer tests in Mexico, USA, Canada, Germany, France and Saudi Arabia. In constant flow rate tests, our results show that derivative analysis is an easy, robust and powerful tool to assess near-borehole damage effects, formation heterogeneity, boundaries, flow regimes, infinite-acting radial stages, i.e., valid Theisian framework, and fracture-driven flow. In step tests, the effectiveness relies on high-frequency drawdown measurements. Moreover, we adapt O&G analytical solutions to cater for the conditions in groundwater systems. In this context, further parameters can be computed analytically from the plots, such as skin factor, head losses, wellbore storage, distance to the boundary, channel-aquifer and/or fracture zone width, among others. Therefore, diagnostic plots should be considered a mandatory tool for pumping tests analysis among hydrogeologists. This project has been supported by DGAPA (UNAM) under the research project PAPIIT IN-112815.

  6. Distributed Access Control Based on Proxy Signature in M2M Sensor Networks

    Directory of Open Access Journals (Sweden)

    Lingyu Lee

    2013-05-01

    Full Text Available In this study, we have a research of the distributed access control based on proxy signature in M2M sensor networks M2M sensor networks. As M2M sensor networks are usually deployed in hostile environment, the global communication security of M2M sensor networks is and will continue to be a major concern. Although there are many related works on access control in WSNs (Wireless Sensor Networks, Ad-hoc networks, MANETs (Mobile Ad-hoc Networks and etc., they cannot be applied to M2M sensor networks directly. Motivated by this consideration, we develop a secure and distributed access control scheme based on proxy signature for M2M sensor networks, which provides strong authentication and achieves efficiency. Moreover, security of the proposed technique does not rely on availability of a secure channel.

  7. Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein

    DEFF Research Database (Denmark)

    Andersson, Anne-Marie Carola; Håkansson, Kjell Ove; Jensen, Benjamin Anderschou Holbech

    2012-01-01

    by diverse influenza A viruses, a vaccine (M2e-NSP4) was constructed linking M2e (in its consensus sequence) to the rotavirus fragment NSP4(98-135); due to its coiled-coil region this fragment is known to form tetramers in aqueous solution and in this manner we hoped to mimick the natural configuration of M2......The ectodomain of the matrix 2 protein (M2e) of influenza A virus represents an attractive target for developing a universal influenza A vaccine, with its sequence being highly conserved amongst human variants of this virus. With the aim of targeting conformational epitopes presumably shared...... reactive antibody response than does M2e peptide as measured in two different assays. Most importantly, vaccination with M2e-NSP4 caused a significant decrease in lung virus load early after challenge with influenza A virus and maintained its efficacy against a lethal challenge even at very low vaccine...

  8. Solidification microstructure of M2 high speed steel by different casting technologies

    OpenAIRE

    Zhou Xuefeng; Fang Feng; Jiang Jianjing

    2011-01-01

    The present work investigated the solidification microstructure of AISI M2 high speed steel manufactured by different casting technologies, namely iron mould casting and continuous casting. The results revealed that the as-cast structure of the steel was composed of the iron matrix and the M2C eutectic carbide networks, which were greatly refined in the ingot made by continuous casting process, compared with that by the iron mould casting process. M2C eutectic carbides presented variation in ...

  9. M2M Communications for E-Health and Smart Grid: An Industry and Standard Perspective

    OpenAIRE

    Fan, Zhong; Haines, Russell J.; Kulkarni, Parag

    2013-01-01

    An overview of several standardization activities for machine-to-machine (M2M) communications is presented, analyzing some of the enabling technologies and applications of M2M in industry sectors such as Smart Grid and e-Health. This summary and overview of the ongoing work in M2M from the industrial and standardization perspective complements the prevalent academic perspective of such publications to date in this field.

  10. Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein

    DEFF Research Database (Denmark)

    Andersson, Anne-Marie Carola; Håkansson, Kjell Ove; Jensen, Benjamin Anderschou Holbech;

    2012-01-01

    The ectodomain of the matrix 2 protein (M2e) of influenza A virus represents an attractive target for developing a universal influenza A vaccine, with its sequence being highly conserved amongst human variants of this virus. With the aim of targeting conformational epitopes presumably shared......e as presented in membranes. M2e-NSP4 was then evaluated side-by-side with synthetic M2e peptide for its immunogenicity and protective efficacy in a murine influenza challenge model. Here we demonstrate that M2e fused to the tetramerizing protein induces an accelerated, augmented and more broadly...

  11. A tool to determine crown and plot canopy transparency for forest inventory and analysis phase 3 plots using digital photographs

    Science.gov (United States)

    Matthew F. Winn; Philip A. Araman

    2012-01-01

    The USDA Forest Service Forest Inventory and Analysis (FIA) program collects crown foliage transparency estimates for individual trees on Phase 3 (P3) inventory plots. The FIA crown foliage estimate is obtained from a pair of perpendicular side views of the tree. Researchers with the USDA Forest Service Southern Research Station have developed a computer program that...

  12. Characteristics of Hebei Xinyue 280m2 sinter project%河北鑫跃280m2烧结机的工艺特点

    Institute of Scientific and Technical Information of China (English)

    宾蓉晖

    2012-01-01

    The process characteristics of bar screen, dust pneumatic conveying, and first mixing de-dusting system were introduced, and the influence on environment protection and energy saving of Hebei Xinyue 280m2 sinter projects were introduced.%介绍了河北鑫跃280m2烧结机工程棒条筛、除尘灰气力输送、一混除尘的工艺特点,以及产生的环保、节能影响.

  13. Evaluation of the Soil Conservation Service curve number methodology using data from agricultural plots

    Science.gov (United States)

    Lal, Mohan; Mishra, S. K.; Pandey, Ashish; Pandey, R. P.; Meena, P. K.; Chaudhary, Anubhav; Jha, Ranjit Kumar; Shreevastava, Ajit Kumar; Kumar, Yogendra

    2016-08-01

    The Soil Conservation Service curve number (SCS-CN) method, also known as the Natural Resources Conservation Service curve number (NRCS-CN) method, is popular for computing the volume of direct surface runoff for a given rainfall event. The performance of the SCS-CN method, based on large rainfall (P) and runoff (Q) datasets of United States watersheds, is evaluated using a large dataset of natural storm events from 27 agricultural plots in India. On the whole, the CN estimates from the National Engineering Handbook (chapter 4) tables do not match those derived from the observed P and Q datasets. As a result, the runoff prediction using former CNs was poor for the data of 22 (out of 24) plots. However, the match was little better for higher CN values, consistent with the general notion that the existing SCS-CN method performs better for high rainfall-runoff (high CN) events. Infiltration capacity (fc) was the main explanatory variable for runoff (or CN) production in study plots as it exhibited the expected inverse relationship between CN and fc. The plot-data optimization yielded initial abstraction coefficient (λ) values from 0 to 0.659 for the ordered dataset and 0 to 0.208 for the natural dataset (with 0 as the most frequent value). Mean and median λ values were, respectively, 0.030 and 0 for the natural rainfall-runoff dataset and 0.108 and 0 for the ordered rainfall-runoff dataset. Runoff estimation was very sensitive to λ and it improved consistently as λ changed from 0.2 to 0.03.

  14. Influence of Surface Biosolids Application on Infiltration

    Directory of Open Access Journals (Sweden)

    Richard E. Zartman

    2012-01-01

    Full Text Available Biosolids from waste water treatment facilities applied to soils not only add plant nutrients, but also increase infiltration and decrease runoff and erosion. Wet biosolids from New York, NY, were surface applied at 0 to 90 Mg ha−1 dry weight to soils near El Paso, Tex. Simulated rainfall intensities of 16.4 cm hr−1 for 30 minutes applied to 0.5 m2 soil plots yielded initial infiltration rates of ~16 cm hr−1 for all plots. Biosolids applications extended the duration of the initially high infiltration rates. After 30 minutes, infiltration rates for bare soil were 3 cm hr−1 without and 10 cm hr−1 with 90 Mg biosolids ha−1. Applied biosolids, plant litter, surface gravel, and plant base contributed surface cover, which absorbed raindrop energy and reduced erosion. Biosolids increased cumulative infiltration on the vegetated, wet soils more than for the dry or bare soils. Biosolids increased cumulative infiltration from 2 to 6 cm on a bare gravelly soil and from 9.3 to 10.6 cm on a vegetated soil.

  15. Sink plot for runoff measurements on semi-flat terrains: preliminary data and their potential hydrological and ecological implications

    Directory of Open Access Journals (Sweden)

    Kidron Giora J.

    2014-12-01

    Full Text Available In arid and semiarid regions where water is the main limiting factor, water redistribution is regarded as an important hydrological process of great ecological value. By providing additional water to certain loci, moist pockets of great productivity are formed, characterized by high plant biomass and biological activity. These moist pockets are often a result of runon. Yet, although runoff may take place on semi-flat undulating surfaces, runoff measurements are thus far confined to slopes, where a sufficient gradient facilitates downslope water harvesting. On undulating surfaces of mounds and depressions, such as in interdunes, no quantification of the amount of water reaching depressions is feasible due to the fact that no reliable method for measuring the runoff amounts in semi-flat terrains is available. The current paper describes specific runoff plots, designed to measure runoff in depressions (sinks. These plots, termed sink plots (SPs, were operative in the Hallamish dunefield (Negev Desert, Israel. The paper presents measurements of runoff yield that were carried out between January 2013 and January 2014 on SPs and compared them to runoff obtained from crusted slope plots and fine-grained (playa surfaces. The potential hydrological and ecological implications of water redistribution within semi-flat terrains for this and other arid ecosystems are discussed.

  16. CADASTRAL CLASSIFICATION OF THE LAND PLOTS IN UKRAINE

    Directory of Open Access Journals (Sweden)

    KIRICHEK Yu. O.

    2016-04-01

    Full Text Available Summary. Work concerns development of national system of classification of the land plots. The developed classification will allow to solve correctly a number of the corresponding cadastral, land management, estimated and other tasks. The analysis of classifications of lands, improvements and real estate in general is made. The created offers concerning creation of a new classification of the land plots in Ukraine. Today the Ukrainian real estate market has no single system that separates the system property groups, classes and types. This significantly complicates the work and can not fully be aware of the specific situation of real estate market. This task is designed to solve classification properties, it is used to transition from a diversity of individual properties to a limited number of classes of evaluation objects. The classification is different functional purpose (use facilities assessment, which determines the difference in value.

  17. Losing the Plot: the Geological Anti-Narrative

    Directory of Open Access Journals (Sweden)

    Adelene Buckland

    2010-09-01

    Full Text Available Geology has often been treated by literary critics as the producer narratives of earth history which were appropriated or resisted by novelists and poets. This paper will problematise this tradition by considering a widespread problematisation of plot as a mode of rational enquiry in the nineteenth century, and which underpinned much literary and geological discourse. Rooting itself in elite, fashionable literary culture, geology often resisted plot as a means of unravelling and describing earth history. Briefly considering the reading and the writings of geologists including Adam Sedgwick, William Buckland and Charles Lyell, this essay demonstrates that geology is a much different case in 'science and literature' than the evolutionary sciences explored by Gillian Beer and George Levine.

  18. [Eugenics, an element of the literary plots of dystopia].

    Science.gov (United States)

    Baum, Ewa; Musielak, Michał

    2007-01-01

    The work presents the ideas and assumptions of eugenics, a social philosophy established in 1883 by Francis Galton, which affected the social policies of numerous European countries in the first half of the 20th century. The work shows the effect of eugenics on the literary standards of European prose in the previous century. Two outstanding dystopian novels of the 20th century, The Brave New World by Aldous Huxley and 1984 by George Orwell, situate eugenics as a permanent element of the literary plot of dystopia. Apart from the typical features of this type of novel, for example: personal narration with a trace of irony, a totalitarian state and Newspeak, eugenics is an important element of the literary plot with is aim to exclude and marginalise certain social groups. Eugenics is also one of the main social ideas criticised by both the writers.

  19. Automated drawing of network plots in network meta-analysis.

    Science.gov (United States)

    Rücker, Gerta; Schwarzer, Guido

    2016-03-01

    In systematic reviews based on network meta-analysis, the network structure should be visualized. Network plots often have been drawn by hand using generic graphical software. A typical way of drawing networks, also implemented in statistical software for network meta-analysis, is a circular representation, often with many crossing lines. We use methods from graph theory in order to generate network plots in an automated way. We give a number of requirements for graph drawing and present an algorithm that fits prespecified ideal distances between the nodes representing the treatments. The method was implemented in the function netgraph of the R package netmeta and applied to a number of networks from the literature. We show that graph representations with a small number of crossing lines are often preferable to circular representations.

  20. The Chymistry of "The Learned Dr Plot" (1640-96).

    Science.gov (United States)

    Roos, Anna Marie

    2014-01-01

    In the seventeenth century, there were developing norms of openness in the presentation of scientific knowledge that were at odds with traditions of secrecy among chymists, particularly practitioners of chrysopoeia, or the transmutation of metals. This chapter analyzes how Dr. Robert Plot, the first professor of chymistry at Oxford, negotiated these boundaries within an institutional context. I first delineate his chymical and experimental practice, which incorporated procedures from medieval alchemical sources, particularly the Lullian corpus, as well as more novel practices from seventeenth-century chymistry. Then, I analyze how personal and institutional ambitions and economic considerations shaped to what extent Plot negotiated the boundaries between secrecy and the public dissemination of chymical knowledge.

  1. [Murderers in white coats--the physicians' plot against Stalin].

    Science.gov (United States)

    Olsen, B

    1997-12-10

    During the Moscow trials in 1936-38 several doctors were sentenced for participating in the murders of party leaders. As others who were accused, the doctors willingly confessed to crimes they could not possibly have committed. A second doctors' plot took place in the autumn of 1952. This time nine doctors, six of them Jews, were arrested for the attempted murder of political leaders. Only the unexpected death of Josef Stalin prevented a new wave of terror. With the single exception of Genrikh Grigorjevitsj Jagoda (1891-1938), head of the NKVD (KGB's predecessor), all those sentenced under the Moscow process are now rehabilitated. The participants of the second doctors' plot were rehabilitated immediately after Stalin's death.

  2. Review article: The mountain motif in the plot of Matthew

    Directory of Open Access Journals (Sweden)

    Gert J. Volschenk

    2010-02-01

    Full Text Available This article reviewed T.L. Donaldson’s book, Jesus on the mountain: A study in Matthean theology, published in 1985 by JSOT Press, Sheffield, and focused on the mountain motif in the structure and plot of the Gospel of Matthew, in addition to the work of Donaldson on the mountain motif as a literary motif and as theological symbol. The mountain is a primary theological setting for Jesus’ ministry and thus is an important setting, serving as one of the literary devices by which Matthew structured and progressed his narrative. The Zion theological and eschatological significance and Second Temple Judaism serve as the historical and theological background for the mountain motif. The last mountain setting (Mt 28:16–20 is the culmination of the three theological themes in the plot of Matthew, namely Christology, ecclesiology and salvation history.

  3. Volcano plots in hydrogen electrocatalysis - uses and abuses.

    Science.gov (United States)

    Quaino, Paola; Juarez, Fernanda; Santos, Elizabeth; Schmickler, Wolfgang

    2014-01-01

    Sabatier's principle suggests, that for hydrogen evolution a plot of the rate constant versus the hydrogen adsorption energy should result in a volcano, and several such plots have been presented in the literature. A thorough examination of the data shows, that there is no volcano once the oxide-covered metals are left out. We examine the factors that govern the reaction rate in the light of our own theory and conclude, that Sabatier's principle is only one of several factors that determine the rate. With the exception of nickel and cobalt, the reaction rate does not decrease for highly exothermic hydrogen adsorption as predicted, because the reaction passes through more suitable intermediate states. The case of nickel is given special attention; since it is a 3d metal, its orbitals are compact and the overlap with hydrogen is too low to make it a good catalyst.

  4. Automatic target recognition based on cross-plot.

    Directory of Open Access Journals (Sweden)

    Kelvin Kian Loong Wong

    Full Text Available Automatic target recognition that relies on rapid feature extraction of real-time target from photo-realistic imaging will enable efficient identification of target patterns. To achieve this objective, Cross-plots of binary patterns are explored as potential signatures for the observed target by high-speed capture of the crucial spatial features using minimal computational resources. Target recognition was implemented based on the proposed pattern recognition concept and tested rigorously for its precision and recall performance. We conclude that Cross-plotting is able to produce a digital fingerprint of a target that correlates efficiently and effectively to signatures of patterns having its identity in a target repository.

  5. Kinetics of Proton Transport into Influenza Virions by the Viral M2 Channel

    NARCIS (Netherlands)

    Ivanovic, Tijana; Rozendaal, Rutger; Floyd, Daniel L.; Popovic, Milos; Oijen, Antoine M. van; Harrison, Stephen C.

    2012-01-01

    M2 protein of influenza A viruses is a tetrameric transmembrane proton channel, which has essential functions both early and late in the virus infectious cycle. Previous studies of proton transport by M2 have been limited to measurements outside the context of the virus particle. We have developed a

  6. Pilot Milt Thompson and the M2-F2 Lifting Body

    Science.gov (United States)

    1966-01-01

    Jay L. King, Joseph D. Huxman and Orion D. Billeter assist NASA research pilot Milt Thompson (on the ladder) into the cockpit of the M2-F2 lifting body research aircraft at the NASA Flight Research Center (now the Dryden Flight Research Center). The M2-F2 is attached to a wing pylon under the wing of NASA's B-52 mothership.

  7. Wound administration of M2-polarized macrophages does not improve murine cutaneous healing responses.

    Science.gov (United States)

    Jetten, Nadine; Roumans, Nadia; Gijbels, Marion J; Romano, Andrea; Post, Mark J; de Winther, Menno P J; van der Hulst, Rene R W J; Xanthoulea, Sofia

    2014-01-01

    Macrophages play a crucial role in all stages of cutaneous wound healing responses and dysregulation of macrophage function can result in derailed wound repair. The phenotype of macrophages is influenced by the wound microenvironment and evolves during healing from a more pro-inflammatory (M1) profile in early stages, to a less inflammatory pro-healing (M2) phenotype in later stages of repair. The aim of the current study was to investigate the potential of exogenous administration of M2 macrophages to promote wound healing in an experimental mouse model of cutaneous injury. Bone marrow derived macrophages were stimulated in-vitro with IL-4 or IL-10 to obtain two different subsets of M2-polarized cells, M2a or M2c respectively. Polarized macrophages were injected into full-thickness excisional skin wounds of either C57BL/6 or diabetic db/db mice. Control groups were injected with non-polarized (M0) macrophages or saline. Our data indicate that despite M2 macrophages exhibit an anti-inflammatory phenotype in-vitro, they do not improve wound closure in wild type mice while they delay healing in diabetic mice. Examination of wounds on day 15 post-injury indicated delayed re-epithelialization and persistence of neutrophils in M2 macrophage treated diabetic wounds. Therefore, topical application of ex-vivo generated M2 macrophages is not beneficial and contraindicated for cell therapy of skin wounds.

  8. Phonological Substitution Errors in L2 ASL Sentence Processing by Hearing M2L2 Learners

    Science.gov (United States)

    Williams, Joshua; Newman, Sharlene

    2016-01-01

    In the present study we aimed to investigate phonological substitution errors made by hearing second language (M2L2) learners of American Sign Language (ASL) during a sentence translation task. Learners saw sentences in ASL that were signed by either a native signer or a M2L2 learner. Learners were to simply translate the sentence from ASL to…

  9. De novo formal synthesis of (-)-virginiamycin M2 via the asymmetric hydration of dienoates.

    Science.gov (United States)

    Mortensen, Matthew S; Osbourn, Joshua M; O'Doherty, George A

    2007-08-02

    A de novo approach to the formal total synthesis of the macrolide natural product (-)-virginiamycin M2 has been achieved via a convergent approach. The absolute and relative stereochemistry of the nonpeptide portion of (-)-virginiamycin M2 was introduced by two Sharpless asymmetric dihydroxylation reactions.

  10. Solid State NMR Observation of Phenylalanine Residues in M2 Protein from Influenza a Virus

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@ The M2 protein from influenza A functions as a proton channel. It has been cloned and over-expressed in Escherchia coli. Large quantities of recombinant protein are purified by Ni2 affinity chromatography. The residues in M2 have been selectively labeled with 15N in an aromatic amino acid autotroph CT19.

  11. Almost optimal distributed M2M multicasting in wireless mesh networks

    DEFF Research Database (Denmark)

    Xin, Qin; Manne, Fredrik; Zhang, Yan

    2012-01-01

    nodes. It is known that the computation of an optimal M2M multicasting schedule isNP-hard. We present a fully distributed deterministic algorithm for such an M2M multicasting problem and analyze its time complexity. We show that if the maximum hop distance between any two out of the k participants is d...

  12. 12 CFR Appendix M2 to Part 226 - Actual Repayment Disclosures

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Actual Repayment Disclosures M2 Appendix M2 to Part 226 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE... nearest whole year if the estimate contains a fractional year less than 0.5, and rounded up to the...

  13. Extended Recurrence Plot Analysis and its Application to ERP Data

    CERN Document Server

    Marwan, N; Marwan, Norbert; Meinke, Anja

    2004-01-01

    We present new measures of complexity and their application to event related potential data. The new measures base on structures of recurrence plots and makes the identification of chaos-chaos transitions possible. The application of these measures to data from single-trials of the Oddball experiment can identify laminar states therein. This offers a new way of analyzing event-related activity on a single-trial basis.

  14. Dispatching policy for manufacturing jobs and time-delay plots

    OpenAIRE

    2007-01-01

    Abstract In this paper, the concepts of chaos and non-linear dynamics are briefly introduced and the tools used in the characterization of a chaotic or non-linear system are discussed for studying the performance of dispatching policies in manufacturing systems. The scheduling of a simple manufacturing system with the help of common assignment rules has been simulated first. The results are studied and analysed with the help of time-delay plots. Some conclusions are drawn and, base...

  15. Method for detecting software anomalies based on recurrence plot analysis

    OpenAIRE

    Michał Mosdorf

    2012-01-01

    Presented paper evaluates method for detecting software anomalies based on recurrence plot analysis of trace log generated by software execution. Described method for detecting software anomalies is based on windowed recurrence quantification analysis for selected measures (e.g. Recurrence rate - RR or Determinism - DET). Initial results show that proposed method is useful in detecting silent software anomalies that do not result in typical crashes (e.g. exceptions).

  16. Method for detecting software anomalies based on recurrence plot analysis

    Directory of Open Access Journals (Sweden)

    Michał Mosdorf

    2012-03-01

    Full Text Available Presented paper evaluates method for detecting software anomalies based on recurrence plot analysis of trace log generated by software execution. Described method for detecting software anomalies is based on windowed recurrence quantification analysis for selected measures (e.g. Recurrence rate - RR or Determinism - DET. Initial results show that proposed method is useful in detecting silent software anomalies that do not result in typical crashes (e.g. exceptions.

  17. Graphical interpretation of confidence curves in rankit plots.

    Science.gov (United States)

    Hyltoft Petersen, Per; Blaabjerg, Ole; Andersen, Marianne; Jørgensen, Lone G M; Schousboe, Karoline; Jensen, Esther

    2004-01-01

    A well-known transformation from the bell-shaped Gaussian (normal) curve to a straight line in the rankit plot is investigated, and a tool for evaluation of the distribution of reference groups is presented. It is based on the confidence intervals for percentiles of the calculated Gaussian distribution and the percentage of cumulative points exceeding these limits. The process is to rank the reference values and plot the cumulative frequency points in a rankit plot with a logarithmic (In=log(e)) transformed abscissa. If the distribution is close to In-Gaussian the cumulative frequency points will fit to the straight line describing the calculated In-Gaussian distribution. The quality of the fit is evaluated by adding confidence intervals (CI) to each point on the line and calculating the percentage of points outside the hyperbola-like CI-curves. The assumption was that the 95% confidence curves for percentiles would show 5% of points outside these limits. However, computer simulations disclosed that approximate 10% of the series would have 5% or more points outside the limits. This is a conservative validation, which is more demanding than the Kolmogorov-Smirnov test. The graphical presentation, however, makes it easy to disclose deviations from In-Gaussianity, and to make other interpretations of the distributions, e.g., comparison to non-Gaussian distributions in the same plot, where the cumulative frequency percentage can be read from the ordinate. A long list of examples of In-Gaussian distributions of subgroups of reference values from healthy individuals is presented. In addition, distributions of values from well-defined diseased individuals may show up as In-Gaussian. It is evident from the examples that the rankit transformation and simple graphical evaluation for non-Gaussianity is a useful tool for the description of sub-groups.

  18. A MATLAB Function for Plotting Phase Planes Interactively

    OpenAIRE

    Forsman, Krister

    1992-01-01

    A MATLAB-function serving as a sort of graphical interface to the MATLAB ODE-solver ode45 is presented. The main use of it is to facilitate phase plane analysis of nonlinear 2-D systems via simulation. The numerical integration of the system is mouse-operated via the ginput-function. After each choice of initial value a simulation is made and plotted in the phase plane.

  19. How to Create and Manipulate Radar Range-Doppler Plots

    Science.gov (United States)

    2014-12-01

    set of wave fronts with constant wavelength, direction, and relative phase. Electromagnetic waves produced by radar transmitters and lasers are... radars . The Matlab function fft orders its DFT amplitudes in a way that renders negative frequencies positive and greater than the Nyquist frequency. I...UNCLASSIFIED How to Create and Manipulate Radar Range–Doppler Plots Don Koks Cyber & Electronic Warfare Division Defence Science and Technology

  20. The value of building plots in Italy - pdf

    Directory of Open Access Journals (Sweden)

    Paolo Rosato

    2014-12-01

    Full Text Available This paper suggests some analysis on dynamics of building plots value in Italy. This is an important subject, since the study of changes in plots value in space and time enables the evaluation of urban rent, which is essential for a fair and effective planning. The analysis confirm past hypothesis which are well known to real estate market operators. The first resulting fact is that the changes in building plots value are concurrent to those in real estate value and the increase occurring in the last years is in relative terms higher than the past one. This seems to confirm that, during real estate market expansion, most of the increase of buildings’ value is attributable to the land rent. The second observation is about value dynamics over time: it has been observed that, during an expansion in demand, the value significantly increases in central areas, much more than in peripheral ones; this means that absolute rent arising from shortage in urban areas is higher than the differential rent created through urban expansion in peripheral areas. Finally, it was highlighted that the factors affecting the value in building areas play different roles, depending on their location relative to the urban centre, identifying differently structured market segments.

  1. Looking at large data sets using binned data plots

    Energy Technology Data Exchange (ETDEWEB)

    Carr, D.B.

    1990-04-01

    This report addresses the monumental challenge of developing exploratory analysis methods for large data sets. The goals of the report are to increase awareness of large data sets problems and to contribute simple graphical methods that address some of the problems. The graphical methods focus on two- and three-dimensional data and common task such as finding outliers and tail structure, assessing central structure and comparing central structures. The methods handle large sample size problems through binning, incorporate information from statistical models and adapt image processing algorithms. Examples demonstrate the application of methods to a variety of publicly available large data sets. The most novel application addresses the too many plots to examine'' problem by using cognostics, computer guiding diagnostics, to prioritize plots. The particular application prioritizes views of computational fluid dynamics solution sets on the fly. That is, as each time step of a solution set is generated on a parallel processor the cognostics algorithms assess virtual plots based on the previous time step. Work in such areas is in its infancy and the examples suggest numerous challenges that remain. 35 refs., 15 figs.

  2. Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain

    Energy Technology Data Exchange (ETDEWEB)

    Ehlert, F.J.; Tran, L.P. (Univ. of California, Irvine (USA))

    1990-12-01

    The distribution of subtypes of the muscarinic receptor in homogenates of the rat brain was investigated by measuring the competitive inhibition of the binding (3H)N-methylscopolamine by pirenzepine and AF-DX 116 (11((2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5, 11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepine-6-one). In most brain regions, the competitive binding curves for AF-DX 116 and pirenzepine were consistent with a two-site model. The dissociation constant of pirenzepine for its high-affinity site (M1 receptor) was approximately 10(-8) M, whereas the dissociation constant of AF-DX 116 for its high affinity site (M2 receptor) was approximately 10(-7) M. In many regions, particularly those in the forebrain, the sum of the densities of the M1 and M2 binding sites was substantially less than 100% of the total sites, indicating the existence of a third population of sites lacking high affinity for both pirenzepine and AF-DX 116. We have designated these latter sites as non-M1, non-M2 muscarinic receptors. In general, the densities of the M1 and non-M1, non-M2 binding sites were highest in cerebral cortex, corpus striatum and hippocampus, intermediate in thalamus and hypothalamus, and lowest in midbrain, medulla-pons and cerebellum, whereas the M2 binding site had a relatively low, uniform density throughout the brain. The binding capacity of (3H)N-methylquinuclidinyl benzilate was estimated to be 20 to 30% lower than that of (3H)quinuclidinyl benzilate in various regions of the forebrain, but not in more caudal regions of the brain where the two radioligands had approximately the same binding capacities.

  3. SOFEPL: A Plotting Postprocessor for ’SOFE’ User’s Manual.

    Science.gov (United States)

    1981-11-01

    area General KPLUSDWork List of plots using Area IPLUSD current run KT (created in PLTNED) PLOT IPlot 1 IA(KLPTP+ 2-1) A AData Area PLOT 2Plot 2 IA...reasons: computer turn-around times for big runs are prohibitively long; a short preliminary evalu- ation of performance is needed before a lot of

  4. ResidPlots-2: Computer Software for IRT Graphical Residual Analyses

    Science.gov (United States)

    Liang, Tie; Han, Kyung T.; Hambleton, Ronald K.

    2009-01-01

    This article discusses the ResidPlots-2, a computer software that provides a powerful tool for IRT graphical residual analyses. ResidPlots-2 consists of two components: a component for computing residual statistics and another component for communicating with users and for plotting the residual graphs. The features of the ResidPlots-2 software are…

  5. Plot and Personification in “Tehran-e- Makhuf“

    Directory of Open Access Journals (Sweden)

    M. Pashaei

    Full Text Available Story is one of the important and influential literary genres that deserves to research on its structure and content .By study and analysis of a story, the reader could comprehend the textual messages and change his attitude toward life and different issues .After defining of the social novel, the author tries to analyze plot and personification in novel of “Tehran-e- Makhuf” and respond to the questions on the method employed for plot and personification and analyze it from plot and its components such as conflict, suspension and resolution and compare the differences and similarities between old tales and modern novels.The plot of “Tehran-e- Makhuf” is not so complex due to its subject and content and natural order of events dominates on artificial discipline and it lacks open plot. Of main elements of plot, conflict is more outstanding here. This novel is full of emotional and moral conflicts and there is no similarity with historical novels that describe good and bad conflicts. Cause and effect relationship is main element of plot that shadows on the story events .In “Tehrna-e- Makhuf”, the author tries to violate the principles and cause to imbalance in natural events sequences with discomposing rational and experiential relationship and take action toward artificiality and unnatural suspension. In creating suspension by emphasis on incidences in some extremist cases, Kazemi tries to found the story based on the considerable sequence of events and this conduct reduces quality of the story significantly and leads to imbalance in rational and acceptable discipline.Kazemi employs direct or reporting personification mostly. This novel lacks diversity in personage considerably .All characters speak in similar style and there is no particular speech style. The personification of Kazemi in “Tehran-e-Makhuf” is continuous and interdependent in style of old tales and novel in European account. In some cases, he approaches to story

  6. M2受体的细胞表征及其运动与心脏、血管M2受体研究进展%Cell Characterization of M2 Receptor and Research Advancement of Exercise Training and Cardiovascular M2 Receptor

    Institute of Scientific and Technical Information of China (English)

    田振军; 杜蕾

    2009-01-01

    目的:探讨M2受体的细胞表征及其运动与心脏、血管M2受体的基础与应用前景.方法:采用文献回顾与前瞻性分析及逻辑推理相结合的方法,跟踪M2受体表征研究进展及其运动与心脏、血管M2受体表征在体育科学领域中的应用.结果与结论:M2受体在心肌、血管平滑肌等细胞上广泛分布,具有重要的生物学功能.不同运动强度和心肌细胞M2受体表征、运动后心率恢复与M2受体基因多态性、心脏运动康复与M2受体表征等的关系密切.积极开展M2受体基因变异与运动前预测心源性死亡风险,运动性心律失常与M2受体表征,运动性心肌损伤引起的心功能紊乱与M2受体表征,基于M2受体靶点的心脏、血管运动康复及其中药有效成份筛选等方面的研究,具有重要的基础研究价值和应用前景.对有效筛选心脏、血管运动康复方案和与M2受体相关药物有效成份具有重大意义.

  7. PET kinetic analysis --pitfalls and a solution for the Logan plot.

    Science.gov (United States)

    Kimura, Yuichi; Naganawa, Mika; Shidahara, Miho; Ikoma, Yoko; Watabe, Hiroshi

    2007-01-01

    The Logan plot is a widely used algorithm for the quantitative analysis of neuroreceptors using PET because it is easy to use and simple to implement. The Logan plot is also suitable for receptor imaging because its algorithm is fast. However, use of the Logan plot, and interpretation of the formed receptor images should be regarded with caution, because noise in PET data causes bias in the Logan plot estimates. In this paper, we describe the basic concept of the Logan plot in detail and introduce three algorithms for the Logan plot. By comparing these algorithms, we demonstrate the pitfalls of the Logan plot and discuss the solution.

  8. Hydrological Modelling Using a Rainfall Simulator over an Experimental Hillslope Plot

    Directory of Open Access Journals (Sweden)

    Arpit Chouksey

    2017-03-01

    Full Text Available Hydrological processes are complex to compute in hilly areas when compared to plain areas. The governing processes behind runoff generation on hillslopes are subsurface storm flow, saturation excess flow, overland flow, return flow and pipe storage. The simulations of the above processes in the soil matrix require detailed hillslope hydrological modelling. In the present study, a hillslope experimental plot has been designed to study the runoff generation processes on the plot scale. The setup is designed keeping in view the natural hillslope conditions prevailing in the Northwestern Himalayas, India where high intensity rainfall events occur frequently. A rainfall simulator was installed over the experimental hillslope plot to generate rainfall with an intensity of 100 mm/h, which represents the dominating rainfall intensity range in the region. Soil moisture sensors were also installed at variable depths from 100 to 1000 mm at different locations of the plot to observe the soil moisture regime. From the experimental observations it was found that once the soil is saturated, it remains at field capacity for the next 24–36 h. Such antecedent moisture conditions are most favorable for the generation of rapid stormflow from hillslopes. A dye infiltration test was performed on the undisturbed soil column to observe the macropore fraction variability over the vegetated hillslopes. The estimated macropore fractions are used as essential input for the hillslope hydrological model. The main objective of the present study was to develop and test a method for estimating runoff responses from natural rainfall over hillslopes of the Northwestern Himalayas using a portable rainfall simulator. Using the experimental data and the developed conceptual model, the overland flow and the subsurface flow through a macropore-dominated area have been estimated/analyzed. The surface and subsurface runoff estimated using the developed hillslope hydrological model

  9. Supplementation of inactivated influenza vaccine with norovirus P particle-M2e chimeric vaccine enhances protection against heterologous virus challenge in chickens

    Science.gov (United States)

    Elaish, Mohamed; Ali, Ahmed; Xia, Ming; Ibrahim, Mahmoud; Jang, Hyesun; Hiremath, Jagadish; Dhakal, Santosh; Helmy, Yosra A.; Jiang, Xi; Renukaradhya, Gourapura J.; Lee, Chang-Won

    2017-01-01

    The current inactivated influenza vaccines provide satisfactory protection against homologous viruses but limited cross-protection against antigenically divergent strains. Consequently, there is a need to develop more broadly protective vaccines. The highly conserved extracellular domain of the matrix protein 2 (M2e) has shown promising results as one of the components of a universal influenza vaccine in different animal models. As an approach to overcome the limited, strain specific, protective efficacy of inactivated influenza vaccine (IIV), a combination of recombinant M2e expressed on the surface of norovirus P particle (M2eP) and IIV was tested in chickens. Co-immunization of birds with both vaccines did not affect the production of M2e-specific IgG antibodies compared to the group vaccinated with M2eP alone. However, the co-immunized birds developed significantly higher pre-challenge hemagglutination inhibition antibody titers against the homologous IIV antigen and heterologous challenge virus. These combined vaccine groups also had cross reactive antibody responses against different viruses (H5, H6, and H7 subtypes) compared to the IIV alone vaccinated group. Upon intranasal challenge with homologous and heterologous viruses, the combined vaccine groups showed greater reduction in viral shedding in tracheal swabs compared to those groups receiving IIV alone. Moreover, M2eP antisera from vaccinated birds were able to bind to the native M2 expressed on the surface of whole virus particles and infected cells, and inhibit virus replication in vitro. Our results support the potential benefit of supplementing IIV with M2eP, to expand the vaccine cross protective efficacy. PMID:28151964

  10. Visualisation of gene expression data - the GE-biplot, the Chip-plot and the Gene-plot.

    Science.gov (United States)

    Pittelkow, Yvonne E; Wilson, Susan R

    2003-01-01

    Visualisation methods for exploring microarray data are particularly important for gaining insight into data from gene expression experiments, such as those concerned with the development of an understanding of gene function and interactions. Further, good visualisation techniques are useful for outlier detection in microarray data and for aiding biological interpretation of results, as well as for presentation of overall summaries of the data. The biplot is particularly useful for the display of microarray data as both the genes and the chips can be simultaneously plotted. In this paper we describe several ordination techniques suitable for exploring microarray data, and we call these the GE-biplot, the Chip-plot and the Gene-plot. The general method is first evaluated on synthetic data simulated in accord with current biological interpretation of microarray data. Then it is applied to two well-known data sets, namely the colon data of Alon et al. (1999) and the leukaemia data of Golub et al. (1999). The usefulness of the approach for interpreting and comparing different analyses of the same data is demonstrated.

  11. Kinked structures of isolated nicotinic receptor M2 helices: a molecular dynamics study.

    Science.gov (United States)

    Sankararamakrishnan, R; Samsom, M S

    1994-12-01

    The pore-lining M2 helix of the nicotinic acetylcholine receptor exhibits a pronounced kink when the corresponding ion channel is in a closed conformation [N. Unwin (1993) Journal of Molecular Biology, Vol. 229, pp. 1101-1124]. We have performed molecular dynamics simulations of isolated 22-residue M2 helices in order to identify a possible molecular origin of this kink. In order to sample a wide range of conformational space, a simulated annealing protocol was used to generate five initial M2 helix structures, each of which was subsequently used as the basis of 300 ps MD simulations. Two helix sequences (M2 alpha and M2 delta) were studied in this manner, resulting in a total of ten 300 ps trajectories. Kinked helices present in the trajectories were identified and energy minimized to yield a total of five different stable kinked structures. For comparison, a similar molecular dynamics simulation of a Leu23 helix yielded no stable kinked structures. In four of the five kinked helices, the kink was stabilized by H bonds between the helix backbone and polar side-chain atoms. Comparison with data from the literature on site-directed mutagenesis of M2 residues suggests that such polar side-chain to main-chain H bonds may also contribute to kinking of M2 helices in the intact channel protein.

  12. Efficiency of incomplete split-plot designs – a compromise between traditional split-plot designs and randomised complete block design

    OpenAIRE

    Kristensen, Kristian; Bigongiali, Federica; Østergård, Hanne

    2008-01-01

    The paper shows, how incomplete split-plot designs can be constructed from -designs and how they can be analysed. The incomplete split-plot design can be regarded as both a practical and statistical compromise between traditional split-plot design and randomised complete block design. The efficiency of the design is compared to traditional split-plot design and randomised complete block design using data from 5 trials carried out using incomplete split-plot designs in Denmark through 2004-20...

  13. Designing inhibitors of M2 proton channel against H1N1 swine influenza virus.

    Directory of Open Access Journals (Sweden)

    Qi-Shi Du

    Full Text Available BACKGROUND: M2 proton channel of H1N1 influenza A virus is the target protein of anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The NMR structure of the M2 channel protein determined by Schnell and Chou (Nature, 2008, 451, 591-595 may help people to solve the drug-resistant problem and develop more powerful new drugs against H1N1 influenza virus. METHODOLOGY: Docking calculation is performed to build the complex structure between receptor M2 proton channel and ligands, including existing drugs amantadine and rimantadine, and two newly designed inhibitors. The computer-aided drug design methods are used to calculate the binding free energies, with the computational biology techniques to analyze the interactions between M2 proton channel and adamantine-based inhibitors. CONCLUSIONS: 1 The NMR structure of M2 proton channel provides a reliable structural basis for rational drug design against influenza virus. 2 The channel gating mechanism and the inhibiting mechanism of M2 proton channel, revealed by the NMR structure of M2 proton channel, provides the new ideas for channel inhibitor design. 3 The newly designed adamantane-based inhibitors based on the modeled structure of H1N1-M2 proton channel have two pharmacophore groups, which act like a "barrel hoop", holding two adjacent helices of the H1N1-M2 tetramer through the two pharmacophore groups outside the channel. 4 The inhibitors with such binding mechanism may overcome the drug resistance problem of influenza A virus to the adamantane-based drugs.

  14. Photocatalytic removal of M(2+) (Ni(2+), Cu(2+), Zn(2+), Cd(2+), Hg(2+) and Ag(+)) over new catalyst CuCrO(2).

    Science.gov (United States)

    Ketir, W; Bouguelia, A; Trari, M

    2008-10-30

    The metal ions M(2+) (Ni(2+), Cu(2+), Zn(2+), Cd(2+), Hg(2+) and Ag(+)) are potentially toxic. Their electro deposition has been carried out in aqueous air-equilibrated CuCrO(2) suspension upon visible illumination. The delafossite CuCrO(2) is p-type semiconductor characterized by a low band gap (1.28 eV) and a long-term chemical stability. The corrosion rate is found to be 10(-2) micromol m(-2)month(-1) in aqua regia. The oxide has been elaborated through nitrate route where the specific surface area is increased via the surface/bulk ratio. A correlation exists between the dark M(2+) adsorption, the redox potential of M(2+/0) couple and the conduction band of CuCrO(2) positioned at -1.06 V(SCE). Ag(+) cannot be photoreduced because of its positive potential located far above the valence band. By contrast, Zn(2+) is efficiently deposited due to the large driving force at the interface. The improved photoactivity of copper with a deposition percentage (90%) is attributed to the strong dark adsorption onto the surface catalyst. The results indicate a competitive effect with the water reduction; it has been observed that the M(2+) deposition goes parallel with the hydrogen evolution. Such behavior is attributed to the low H(2) over voltage when ultra fine aggregate of M islands are photodeposited onto CuCrO(2) substrate.

  15. Evaluation of secure capability-based access control in the M2M local cloud platform

    DEFF Research Database (Denmark)

    Anggorojati, Bayu; Prasad, Neeli R.; Prasad, Ramjee

    2016-01-01

    of multiple distributed M2M gateways, creating new challenges in the access control. Some existing access control systems lack in scalability and flexibility to manage access from users or entity that belong to different authorization domains, or fails to provide fine grained and flexible access right...... delegation. Recently, the capability based access control has been considered as method to manage access in the Internet of Things (IoT) or M2M domain. In this paper, the implementation and evaluation of a proposed secure capability based access control in the M2M local cloud platform is presented...

  16. Aggregation and Trunking of M2M Traffic via D2D Connections

    DEFF Research Database (Denmark)

    Rigazzi, Giovanni; Kiilerich Pratas, Nuno; Popovski, Petar

    2015-01-01

    Machine-to-Machine (M2M) communications is one of the key enablers of the Internet of Things (IoT). Billions of devices are expected to be deployed in the near future for novel M2M applications demanding ubiquitous access and global connectivity. In order to cope with the massive number of machines......, there is a need for new techniques to coordinate the access and allocate the resources. Although the majority of the proposed solutions are focused on the adaptation of the traditional cellular networks to the M2M traffic patterns, novel approaches based on the direct communication among nearby devices may...

  17. From a 32 m2 system with 90 CPV modules to a 105 m2 system with 12 CPV modules - Soitec's new CPV system CX-S530

    Science.gov (United States)

    Gombert, Andreas; Wanka, Sven; Gerster, Eckart; van Riesen, Sascha; Neubauer, Martin; Lange, Gerrit; Hamidi, Amir; Burke, Thomas; Stör, Jakob; Aipperspach, Wolfgang; Taliercio, Cecile; Mader, Lucas; Valli, Alessandro; Ziegler, Martin; Hepp, Stefan; Heile, Inka; Gerstmaier, Tobias; Haarburger, Karl-Friedrich

    2012-10-01

    In 2008, Soitec started to launch a 32m2 CPV system which included 90 modules per tracker. In order to realize the fast installation of multi-MW power plants the CPV module CX-M500 with an aperture area of 7,84 m2 was developed together with the new tracker CX-T030 which is optimized for carrying 12 of the new modules. This paper gives an overview over the evolution of this CPV system. The module is based on components of the field proven earlier Concentrix module generations. The tracker is a classical pylon type with two AC motor powered slewing ring drives. A new control device was developed which uses the power-optimized sun tracking algorithm. The major development steps and their results are presented.

  18. Induction of murine macrophage M2 polarization by cigarette smoke extract via the JAK2/STAT3 pathway.

    Directory of Open Access Journals (Sweden)

    Fengjiao Yuan

    Full Text Available Cigarette smoking is a major pathogenic factor in lung cancer. Macrophages play an important role in host defense and adaptive immunity. These cells display diverse phenotypes for performing different functions. M2 type macrophages usually exhibit immunosuppressive and tumor-promoting characteristics. Although macrophage polarization toward the M2 phenotype has been observed in the lungs of cigarette smokers, the molecular basis of the process remains unclear. In this study, we evaluated the possible mechanisms for the polarization of mouse macrophages that are induced by cigarette smoking (CS or cigarette smoke extract (CSE. The results showed that exposure to CSE suppressed the production of reactive oxygen species (ROS and nitric oxide (NO and down-regulated the phagocytic ability of Ana-1 cells. The CD163 expressions on the surface of macrophages from different sources were significantly increased in in vivo and in vitro studies. The M1 macrophage cytokines TNF-α, IL-12p40 and enzyme iNOS decreased in the culture supernatant, and their mRNA levels decreased depending on the time and concentration of CSE. In contrast, the M2 phenotype macrophage cytokines IL-10, IL-6, TGF-β1 and TGF-β2 were up-regulated. Moreover, phosphorylation of JAK2 and STAT3 was observed after the Ana-1 cells were treated with CSE. In addition, pretreating the Ana-1 cells with the STAT3 phosphorylation inhibitor WP1066 inhibited the CSE-induced CD163 expression, increased the mRNA level of IL-10 and significantly decreased the mRNA level of IL-12. In conclusion, we demonstrated that the M2 polarization of macrophages induced by CS could be mediated through JAK2/STAT3 pathway activation.

  19. Soil Carbon Accumulation and CO2 Flux in Experimental Restoration Plots, Southern Iceland: Comparing Soil Treatment Strategies

    Directory of Open Access Journals (Sweden)

    Lawrence H. Tanner

    2015-01-01

    Full Text Available Experimental plots were established on severely eroded land surfaces in Iceland in 1999 to study the rates and limits of soil carbon sequestration during restoration and succession. The carbon content in the upper 10 cm of soils increased substantially during the initial eight years in all plots for which the treatments included both fertilizer and seeding with grasses, concomitant with the increase in vegetative cover. In the following five years, however, the soil carbon accumulation rates declined to negligible for most treatments and the carbon content in soils mainly remained relatively constant. We suggest that burial of vegetated surfaces by aeolian drift and nutrient limitation inhibited productivity and carbon sequestration in most plots. Only plots seeded with lupine demonstrated continued long-term soil carbon accumulation and soil CO2 flux rates significantly higher than background levels. This demonstrates that lupine was the sole treatment that resulted in vegetation capable of sustained growth independent of nutrient availability and resistant to disruption by aeolian processes.

  20. Can complementarity in water use help to explain diversity-productivity relationships in experimental grassland plots?

    Science.gov (United States)

    Verheyen, Kris; Bulteel, Hugo; Palmborg, Cecilia; Olivié, Bert; Nijs, Ivan; Raes, Dirk; Muys, Bart

    2008-05-01

    Positive diversity-productivity relationships have repeatedly been found in experimental grassland plots, but mechanistic explanations are still under debate. We tested whether complementarity for the exploitation of the soil water resource helps to explain these relationships. In the dry summer of 2003, evapotranspiration (ET) was assessed at the Swedish BIODEPTH site using two different approaches: snapshot measurements of canopy surface temperature and simulation of time-accumulated ET by means of a soil water balance model. More diverse plots were characterized by lower surface temperatures and higher accumulated ET. Transgressive overyielding tests revealed that ET in polycultures was higher than in the best-performing monocultures, but this pattern was reversed at high degrees of water stress. Our results indicate that a more complete exploitation of soil water by more diverse grassland systems is on the one hand likely to be a driver for their increased biomass production, but on the other hand causes the more diverse communities to be affected earlier by drought. Nevertheless, the results also suggest that productivity may (at least partially) be maintained under dry conditions due to the higher likelihood of including drought-tolerant species in the more diverse communities.

  1. Plant species richness enhances nitrogen retention in green roof plots.

    Science.gov (United States)

    Johnson, Catherine; Schweinhart, Shelbye; Buffam, Ishi

    2016-10-01

    Vegetated (green) roofs have become common in many cities and are projected to continue to increase in coverage, but little is known about the ecological properties of these engineered ecosystems. In this study, we tested the biodiversity-ecosystem function hypothesis using commercially available green roof trays as replicated plots with varying levels of plant species richness (0, 1, 3, or 6 common green roof species per plot, using plants with different functional characteristics). We estimated accumulated plant biomass near the peak of the first full growing season (July 2013) and measured runoff volume after nearly every rain event from September 2012 to September 2013 (33 events) and runoff fluxes of inorganic nutrients ammonium, nitrate, and phosphate from a subset of 10 events. We found that (1) total plant biomass increased with increasing species richness, (2) green roof plots were effective at reducing storm runoff, with vegetation increasing water retention more than soil-like substrate alone, but there was no significant effect of plant species identity or richness on runoff volume, (3) green roof substrate was a significant source of phosphate, regardless of presence/absence of plants, and (4) dissolved inorganic nitrogen (DIN = nitrate + ammonium) runoff fluxes were different among plant species and decreased significantly with increasing plant species richness. The variation in N retention was positively related to variation in plant biomass. Notably, the increased biomass and N retention with species richness in this engineered ecosystem are similar to patterns observed in published studies from grasslands and other well-studied ecosystems. We suggest that more diverse plantings on vegetated roofs may enhance the retention capacity for reactive nitrogen. This is of importance for the sustained health of vegetated roof ecosystems, which over time often experience nitrogen limitation, and is also relevant for water quality in receiving waters

  2. Crown condition assessment at the CONECOFOR Permanent Monitoring Plots

    Directory of Open Access Journals (Sweden)

    Renzo NIBBI

    2002-09-01

    Full Text Available A detailed crown condition assessment is currently being carried out at the CONECOFOR (CONtrollo ECOsistemi FORestali, Control of Forest Ecosystems plots. The assessment began in 1996, and during the first two years (1996 and 1997 an assessment form based on previous regional experience was used; in 1998 the new official EU form was adopted. The resulting loss of comparability means that only a few indices can be used in the temporal series 1996-1999. Much effort was devoted to Quality Assurance (QA procedures. The QA program is structured as follows: (i specific field manuals have been adopted and are continuously updated; (ii a national training and intercalibration course (NT&IC is undertaken yearly before beginning the assessment campaign;( iii field checks are carried out yearly on a large number of plots. The results of the QA program have shown that for several indices the quality objectives were not reached, but the quality of the data is improving with time. To express the change in crown conditions in each area, a complex index (CCI = Crown Condition Index was adopted. This index is the result of the sum of the relativized values of all the common indices used during the four years. The following parameters were used: transparency, ramification type, leaf colour alteration extension, leaf damage extension, alteration of leaf distension extension. The range within which the CCI fluctuates was evaluated taking into account all the observations carried out at a given plot throughout the years. The number of cases over a given threshold (outliers was calculated for each year. The threshold for outliers was calculated as the median value plus 2 times the range of the interquartile value. All individual cases exceeding this value are considered outliers. The results are presented for all the areas in which the data set is complete for the four years. The yearly fluctuations are discussed and related to possible causes.

  3. Driver for solar cell i-v characteristic plots

    Energy Technology Data Exchange (ETDEWEB)

    Turner, G.B.

    1980-01-15

    A bipolar voltage ramp generator applies a linear voltage through a resistor to a solar cell for plotting its current versus voltage (I-v) characteristic between short circuit and open circuit conditions, with automatic stops at the end points. The resistor serves the multiple purpose of providing a current sensing resistor, setting the full-scale current value, and providing a load line with a slope approximately equal to one, such that it will pass through the origin and the approximate center of the i-v curve with about equal distance from that center to each of the end points.

  4. The Alienated Plot in The End of the Road

    Institute of Scientific and Technical Information of China (English)

    王丽娜

    2014-01-01

    The End of the Road is John Barth’s second novel, and it is the first novel that brought abortion to the focus of public attention, which proves to be a huge success. This paper intends to study the alienation in The End of the Road based on the alienation as a literary style and the alienation embodied in the literary context. Through the analysis of the alienated plot, the pa-per aims to emphasize the internal cause for the end of the different character ’s road.

  5. Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype.

    Directory of Open Access Journals (Sweden)

    Michael J V White

    Full Text Available For both wound healing and the formation of a fibrotic lesion, circulating monocytes enter the tissue and differentiate into fibroblast-like cells called fibrocytes and pro-fibrotic M2a macrophages, which together with fibroblasts form scar tissue. Monocytes can also differentiate into classically activated M1 macrophages and alternatively activated M2 macrophages. The proteases thrombin, which is activated during blood clotting, and tryptase, which is released by activated mast cells, potentiate fibroblast proliferation and fibrocyte differentiation, but their effect on macrophages is unknown. Here we report that thrombin, tryptase, and the protease trypsin bias human macrophage differentiation towards a pro-fibrotic M2a phenotype expressing high levels of galectin-3 from unpolarized monocytes, or from M1 and M2 macrophages, and that these effects appear to operate through protease-activated receptors. These results suggest that proteases can initiate scar tissue formation by affecting fibroblasts, fibrocytes, and macrophages.

  6. HF183/BFDrev and HumM2 qPCR data

    Data.gov (United States)

    U.S. Environmental Protection Agency — Concentration estimates for HF183/BFDrev and HumM2 qPCR genetic markers in raw sewage collected from 54 geographic locations across the United States. This dataset...

  7. Vanishing Str M2 in the presence of anomalous U A(1)

    Science.gov (United States)

    Lopez, Jorge L.; Nanopoulos, D. V.

    1996-02-01

    We show that the presence of an anomalous U A(1) factor in the gauge group of string-derived models may have the new and important phenomenological consequence of allowing the vanishing of Str M2 in the “shifted” vacuum that results in the process of cancelling the anomalous U A(1). The feasibility of this effect seems to be enhanced by a vanishing vacuum energy, and by a “small” value of Str M2 in the original vacuum. In the class of free-fermionic models with vanishing vacuum energy that we focus on, a necessary condition for this mechanism to be effective is that Str M2 > 0 in the original vacuum. A vanishing Str M2 ameliorates the cosmological constant problem and is a necessary element in the stability of the no-scale mechanism.

  8. Reliable Radio Access for Massive Machine-to-Machine (M2M) Communication

    DEFF Research Database (Denmark)

    Madueño, Germán Corrales

    Machine-to-Machine (M2M) communication is a term that identifies the emerging paradigm of interconnected systems, machines, and things that communicate and collaborate without human intervention. The characteristics of M2M Communications are small payloads and sporadic transmissions, while...... the service requirements can range from massive number of devices to ultra-reliable. This PhD thesis focuses on novel mechanisms to meet these requirements in a variety of wireless systems, from well-established technologies such as cellular networks, to emerging technologies like IEEE 802.11ah. Today...... an overwhelming 89% of the deployed M2M modules are GPRS-based. This motivates us to investigate the potential of GPRS as a dedicated M2M network. We show that by introducing minimal modifications to GPRS operation, a large number of devices can be reliably supported. Surprisingly, even though LTE is seen...

  9. Direct observation of the M2 phase with its Mott transition in a VO2 film

    Science.gov (United States)

    Kim, Hoon; Slusar, Tetiana V.; Wulferding, Dirk; Yang, Ilkyu; Cho, Jin-Cheol; Lee, Minkyung; Choi, Hee Cheul; Jeong, Yoon Hee; Kim, Hyun-Tak; Kim, Jeehoon

    2016-12-01

    In VO2, the explicit origin of the insulator-to-metal transition is still disputable between Peierls and Mott insulators. Along with the controversy, its second monoclinic (M2) phase has received considerable attention due to the presence of electron correlation in undimerized vanadium ions. However, the origin of the M2 phase is still obscure. Here, we study a granular VO2 film using conductive atomic force microscopy and Raman scattering. Upon the structural transition from monoclinic to rutile, we observe directly an intermediate state showing the coexistence of monoclinic M1 and M2 phases. The conductivity near the grain boundary in this regime is six times larger than that of the grain core, producing a donut-like landscape. Our results reveal an intra-grain percolation process, indicating that VO2 with the M2 phase is a Mott insulator.

  10. The challenges of M2M massive access in wireless cellular networks

    National Research Council Canada - National Science Library

    Biral, Andrea; Centenaro, Marco; Zanella, Andrea; Vangelista, Lorenzo; Zorzi, Michele

    2015-01-01

    .... Nonetheless, general consensus has been reached upon some specific challenges, such as the need for 5G wireless access networks to support massive access by MTDs, as a consequence of the proliferation of M2M services...

  11. Segal-Bargmann Transform and Paley-Wiener Theorems on $M(2)$

    Indian Academy of Sciences (India)

    E K Narayanan; Suparna Sen

    2010-04-01

    We study the Segal–Bargmann transform on $M(2)$. The range of this transform is characterized as a weighted Bergman space. In a similar fashion Poisson integrals are investigated. Using a Gutzmer’s type formula we characterize the range as a class of functions extending holomorphically to an appropriate domain in the complexification of $M(2)$. We also prove a Paley–Wiener theorem for the inverse Fourier transform.

  12. Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses

    OpenAIRE

    Nadine Jetten; Nadia Roumans; Marion J. Gijbels; Andrea Romano; Post, Mark J.; de Winther, Menno P.J.; Van der Hulst, Rene R. W. J.; Sofia Xanthoulea

    2014-01-01

    Macrophages play a crucial role in all stages of cutaneous wound healing responses and dysregulation of macrophage function can result in derailed wound repair. The phenotype of macrophages is influenced by the wound microenvironment and evolves during healing from a more pro-inflammatory (M1) profile in early stages, to a less inflammatory pro-healing (M2) phenotype in later stages of repair. The aim of the current study was to investigate the potential of exogenous administration of M2 macr...

  13. 10D massive type IIA supergravities as the uplift of parabolic M2-brane torus bundles

    Energy Technology Data Exchange (ETDEWEB)

    Garcia del Moral, Maria Pilar [Universidad de Antofagasta (Chile). Dept. de Fisica; Restuccia, Alvaro [Universidad de Antofagasta (Chile). Dept. de Fisica; Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of). Dept. de Fisica

    2016-04-15

    We remark that the two 10D massive deformations of the N = 2 maximal type IIA supergravity (Romans and HLW supergravity) are associated to the low energy limit of the uplift to 10D of M2-brane torus bundles with parabolic monodromy linearly and non-linearly realized respectively. Romans supergravity corresponds to M2-brane compactified on a twice-punctured torus bundle. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  14. A novel M2e based flu vaccine formulation for dogs.

    Directory of Open Access Journals (Sweden)

    Denis Leclerc

    Full Text Available BACKGROUND: The USA 2004 influenza virus outbreak H3N8 in dogs heralded the emergence of a new disease in this species. A new inactivated H3N8 vaccine was developed to control the spread of the disease but, as in humans and swine, it is anticipated that the virus will mutate shift and drift in the dog population. Therefore, there is a need for a vaccine that can trigger a broad protection to prevent the spread of the virus and the emergence of new strains. METHODOLOGY AND PRINCIPAL FINDINGS: The universal M2e peptide is identical in almost all the H3N8 influenza strains sequenced to date and known to infect dogs. This epitope is therefore a good choice for development of a vaccine to provide broad protection. Malva mosaic virus (MaMV nanoparticles were chosen as a vaccine platform to improve the stability of the M2e peptide and increase its immunogenicity in animals. The addition of an adjuvant (OmpC purified from Salmonella typhi membrane in the vaccine formulation increased the immune response directed to the M2e peptide significantly and enlarged the protection to include the heterosubtypic strain of influenza in a mouse model. An optimal vaccine formulation was also shown to be immunogenic in dogs. CONCLUSIONS AND SIGNIFICANCE: The MaMV vaccine platform triggered an improved immune response directed towards the universal M2e peptide. The adjuvant OmpC increased the immune response to the M2e peptide and protection to a heterosubtypic influenza strain that harbors a different M2e peptide in a mouse model. Antibodies generated by the vaccine formulation showed cross-reactivity with M2e peptides derived from influenza strains H9N2, H5N1 and H1N1. The vaccine formulation shows a potential for commercialization of a new M2e based vaccine in dogs.

  15. M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.

    Science.gov (United States)

    Morgan, Hugh P; O'Reilly, Francis J; Wear, Martin A; O'Neill, J Robert; Fothergill-Gilmore, Linda A; Hupp, Ted; Walkinshaw, Malcolm D

    2013-04-09

    We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule metabolites. Phenylalanine stabilizes an inactive T-state tetrameric conformer and inhibits M2PYK with an IC50 value of 0.24 mM, whereas thyroid hormone (triiodo-L-thyronine, T3) stabilizes an inactive monomeric form of M2PYK with an IC50 of 78 nM. The allosteric activator fructose-1,6-bisphosphate [F16BP, AC50 (concentration that gives 50% activation) of 7 μM] shifts the equilibrium to the tetrameric active R-state, which has a similar activity to that of the constitutively fully active isoform M1PYK. Proliferation assays using HCT-116 cells showed that addition of inhibitors phenylalanine and T3 both increased cell proliferation, whereas addition of the activator F16BP reduced proliferation. F16BP abrogates the inhibitory effect of both phenylalanine and T3, highlighting a dominant role of M2PYK allosteric activation in the regulation of cancer proliferation. X-ray structures show constitutively fully active M1PYK and F16BP-bound M2PYK in an R-state conformation with a lysine at the dimer-interface acting as a peg in a hole, locking the active tetramer conformation. Binding of phenylalanine in an allosteric pocket induces a 13° rotation of the protomers, destroying the peg-in-hole R-state interface. This distinct T-state tetramer is stabilized by flipped out Trp/Arg side chains that stack across the dimer interface. X-ray structures and biophysical binding data of M2PYK complexes explain how, at a molecular level, fluctuations in concentrations of amino acids, thyroid hormone, and glucose metabolites switch M2PYK on and off to provide the cell with a nutrient sensing and growth signaling mechanism.

  16. Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms.

    Directory of Open Access Journals (Sweden)

    Becky J Proskocil

    Full Text Available BACKGROUND: Epidemiological studies link organophosphorus pesticide (OP exposures to asthma, and we have shown that the OPs chlorpyrifos, diazinon and parathion cause airway hyperreactivity in guinea pigs 24 hr after a single subcutaneous injection. OP-induced airway hyperreactivity involves M2 muscarinic receptor dysfunction on airway nerves independent of acetylcholinesterase (AChE inhibition, but how OPs inhibit neuronal M2 receptors in airways is not known. In the central nervous system, OPs interact directly with neurons to alter muscarinic receptor function or expression; therefore, in this study we tested whether the OP parathion or its oxon metabolite, paraoxon, might decrease M2 receptor function on peripheral neurons via similar direct mechanisms. METHODOLOGY/PRINCIPAL FINDINGS: Intravenous administration of paraoxon, but not parathion, caused acute frequency-dependent potentiation of vagally-induced bronchoconstriction and increased electrical field stimulation (EFS-induced contractions in isolated trachea independent of AChE inhibition. However, paraoxon had no effect on vagally-induced bradycardia in intact guinea pigs or EFS-induced contractions in isolated ileum, suggesting mechanisms other than pharmacologic antagonism of M2 receptors. Paraoxon did not alter M2 receptor expression in cultured cells at the mRNA or protein level as determined by quantitative RT-PCR and radio-ligand binding assays, respectively. Additionally, a biotin-labeled fluorophosphonate, which was used as a probe to identify molecular targets phosphorylated by OPs, did not phosphorylate proteins in guinea pig cardiac membranes that were recognized by M2 receptor antibodies. CONCLUSIONS/SIGNIFICANCE: These data indicate that neither direct pharmacologic antagonism nor downregulated expression of M2 receptors contributes to OP inhibition of M2 function in airway nerves, adding to the growing evidence of non-cholinergic mechanisms of OP neurotoxicity.

  17. Enhanced M1/M2 macrophage ratio promotes orthodontic root resorption.

    Science.gov (United States)

    He, D; Kou, X; Luo, Q; Yang, R; Liu, D; Wang, X; Song, Y; Cao, H; Zeng, M; Gan, Y; Zhou, Y

    2015-01-01

    Mechanical force-induced orthodontic root resorption is a major clinical challenge in orthodontic treatment. Macrophages play an important role in orthodontic root resorption, but the underlying mechanism remains unclear. In this study, we examined the mechanism by which the ratio of M1 to M2 macrophage polarization affects root resorption during orthodontic tooth movement. Root resorption occurred when nickel-titanium coil springs were applied on the upper first molars of rats for 3 to 14 d. Positively stained odontoclasts or osteoclasts with tartrate-resistant acid phosphatase were found in resorption areas. Meanwhile, M1-like macrophages positive for CD68 and inducible nitric oxide synthase (iNOS) persistently accumulated on the compression side of periodontal tissues. In addition, the expressions of the M1 activator interferon-γ and the M1-associated pro-inflammatory cytokine tumor necrosis factor (TNF)-α were upregulated on the compression side of periodontal tissues. When the coil springs were removed at the 14th day after orthodontic force application, root resorption was partially rescued. The number of CD68(+)CD163(+) M2-like macrophages gradually increased on the compression side of periodontal tissues. The levels of M2 activator interleukin (IL)-4 and the M2-associated anti-inflammatory cytokine IL-10 also increased. Systemic injection of the TNF-α inhibitor etanercept or IL-4 attenuated the severity of root resorption and decreased the ratio of M1 to M2 macrophages. These data imply that the balance between M1 and M2 macrophages affects orthodontic root resorption. Root resorption was aggravated by an enhanced M1/M2 ratio but was partially rescued by a reduced M1/M2 ratio.

  18. M2C Precipitate in Isothermal Tempering of High Co-Ni Alloy Steel

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The ultra-strength alloy steel with high content of Co and Ni is typical tempering martensite steel, and the secondary hardening is accomplished by the precipitation of fine scale alloy carbides with black-white contrast until peak-hardening. The crystal structure of precipitates was well determined as M2C with hexagonal by micro-beam diffraction. Observing in HREM, M2C carbides were shown coherent with the ferrite matrix completely and have their own structure.

  19. Influence of cladding layer field of slab waveguide on M2 factor

    Institute of Scientific and Technical Information of China (English)

    Bin Lin(林斌); Xuejin Wen(文学金); Fuyuan Guo(郭福源)

    2003-01-01

    Based on the theory of semiconductor laser pattern and the non-paraxial vectorial moment theory of lightbeam propagation, the beam quality factor M2 of TE0 propagating mode is analyzed and calculated.The result shows that when both core layer and cladding layer are considered, M2 > 1 is always obtained.Moreover, by analyzing the characteristic of real beams, this result is generalized to the multilayer isotropiclinear slab waveguides.

  20. Effect of organophosphorus insecticides on phosphorylation of the M2 muscarinic acetylcholine receptor

    Institute of Scientific and Technical Information of China (English)

    Shuyin Li; Liming Zou; Carry Pope

    2008-01-01

    BACKGROUND: Organophosphorus insecticides may promote the accumulation of acetylcholine at synapses and the neuromuscular junction by inhibiting acetylcholinesterase activity to cause disturbance of neural signal conduction and induce a toxic reaction. Organophosphorus insecticides may act on M2 muscarinic acetylcholine receptors, whose combination with G proteins is regulated by phosphorylation of G protein-coupled receptor kinase 2.OBJECTIVE: To investigate the effects of organophosphorus insecticides on the phosphorylation of G protein-coupled receptor kinase 2-mediated M2 muscarinic acetylcholine receptors and to reveal other possible actions of organophosphorus insecticides.DESIGN, TIME AND SETTING: An observational study, which was performed in the Central Laboratory of Shenyang Medical College, and Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University from June 2002 to December 2004.METHODS: The M2 muscarinic acetylcholine receptor was extracted and purified from pig brain using affinity chromatography. Subsequently, the purified M2 muscarinic acetylcholine receptor, G protein-coupled receptor kinase 2, and [OP32] ATP were incubated with different concentrations of paraoxon and chlorpyrifos oxon together. The mixture then underwent polyacrylamide gel electrophoresis, and the gel film was dried and radioactively autographed to detect phosphorylation of the M2 muscarinic acetylcholine receptor. Finally, the radio-labeled phosphorylated M2 receptor protein band was excised for counting with an isotope liquid scintillation counter.MAIN OUTCOME MEASURES: Effects of chlorpyrifos oxon, paraoxon, chlorpyrifos, and parathion in different concentrations on the phosphorylation of the M2 muscarinic acetylcholine receptor; effects of chlorpyrifos oxon on the phosphorylation of the adrenergic receptor.CONCLUSION: Different kinds of organophosphorus insecticides have different effects on the phosphorylation of the G protein

  1. Abundance, distribution, mobility and oligomeric state of M2 muscarinic acetylcholine receptors in live cardiac muscle

    OpenAIRE

    Nenasheva, Tatiana A.; Neary, Marianne; Gregory I. Mashanov; Birdsall, Nigel J.M.; Breckenridge, Ross A.; Molloy, Justin E.

    2013-01-01

    M2 muscarinic acetylcholine receptors modulate cardiac rhythm via regulation of the inward potassium current. To increase our understanding of M2 receptor physiology we used Total Internal Reflection Fluorescence Microscopy to visualize individual receptors at the plasma membrane of transformed CHOM2 cells, a cardiac cell line (HL-1), primary cardiomyocytes and tissue slices from pre- and post-natal mice. Receptor expression levels between individual cells in dissociated cardiomyocytes and he...

  2. Tumor M2 pyruvate kinase: a tumor marker and its clinical application in gastrointestinal malignancy.

    Science.gov (United States)

    Hardt, Philip D; Ewald, Nils

    2008-09-01

    Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel tumor marker that can be determined in EDTA-plasma and in the feces. It has been used in diagnosis and surveillance of a variety of malignant diseases. As compared with the established tumor markers, Tumor M2-PK in EDTA-plasma proves to have at least equal sensitivity in pancreatic, gastric, esophageal, colorectal and cholangiocellular cancer. In combination with established tumor markers, EDTA-plasma M2-PK is a useful tool in diagnosis and surveillance of gastrointestinal tumors. In colorectal cancer, M2-PK in EDTA-plasma even proves superiority as compared with CEA. Fecal Tumor M2-PK testing resembles a good noninvasive screening parameter for colorectal cancer with a reported sensitivity of 68.8-91.0% and a specificity of 71.9-100%. It is superior to fecal occult blood testing in colorectal cancer screening. Since it is effective, easy to handle and bears rather low costs, fecal Tumor M2-PK testing is recommended for large-scale CRC screening.

  3. Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes

    Directory of Open Access Journals (Sweden)

    G. Karina Chimal-Ramírez

    2016-01-01

    Full Text Available Macrophages facilitate breast cancer progression. Macrophages were initially classified as M1 or M2 based on their distinct metabolic programs and then expanded to include antitumoral (M1 and protumoral (M2 activities. However, it is still uncertain what markers define the pro- and antitumoral phenotypes and what conditions lead to their formation. In this study, monocytic cell lines and primary monocytes were subjected to commonly reported protocols of M1/M2 polarization and conditions known to engage monocytes into protumoral functions. The results showed that only IDO enzyme and CD86 M1 markers were upregulated correlating with M1 polarization. TNF-α, CCR7, IL-10, arginase I, CD36, and CD163 were expressed indistinguishably from M1 or M2 polarization. Similarly, protumoral engaging resulted in upregulation of both M1 and M2 markers, with conditioned media from the most aggressive breast cancer cell line promoting the greatest changes. In spite of the mixed phenotype, M1-polarized macrophages exhibited the highest expression/secretion of inflammatory mediators, many of which have previously been associated with breast cancer aggressiveness. These data argue that although the existence of protumoral macrophages is unquestionable, their associated phenotypes and the precise conditions driving their formation are still unclear, and those conditions may need both M1 and M2 stimuli.

  4. Reliable Reporting for Massive M2M Communications with Periodic Resource Pooling

    DEFF Research Database (Denmark)

    Madueño, Germán Corrales; Stefanovic, Cedomir; Popovski, Petar

    2014-01-01

    This letter considers a wireless M2M communication scenario with a massive number of M2M devices. Each device needs to send its reports within a given deadline and with certain reliability, e.g., 99.99%. A pool of resources available to all M2M devices is periodically available for transmission....... The number of transmissions required by an M2M device within the pool is random due to two reasons - random number of arrived reports since the last reporting opportunity and requests for retransmission due to random channel errors. We show how to dimension the pool of M2M-dedicated resources in order...... to guarantee the desired reliability of the report delivery within the deadline. The fact that the pool of resources is used by a massive number of devices allows to base the dimensioning on the central limit theorem. The results are interpreted in the context of LTE, but they are applicable to any M2M...

  5. Study into the Applicability of Laser Beam Quality Factor M2

    Institute of Scientific and Technical Information of China (English)

    YANG Jing; TIAN Xiao-hong; XIN Jian-guo

    2006-01-01

    The applicable condition of single-frequency laser beam quality factor M2 is studied. Any real single-frequency laser beam can be classified as Gaussian mode and non-Gaussian mode according to the transverse field distribution. Non-Gaussian transverse field distribution can be analytically expressed as the sum of Hermite-Gaussian functions. The propagation function and M2 factor expression for non-Gaussian mode can be obtained by the second moment definition of laser beam spot. The analytical results show, the same as that of Gaussian mode, that the propagation function follows the hyperbolic law and the value of M2 factor is a constant for non-Gaussian mode. But, different non-Gaussian field distributions may have the same M2 value. That means M2 factor cannot reflect the quality of non-Gaussian laser beams correctly. We conclude that the M2 factor is applicable only to ideal Gaussian laser beam generated by stable resonators.

  6. Muscarinic cholinergic receptor (M2 plays a crucial role in the development of myopia in mice

    Directory of Open Access Journals (Sweden)

    Veluchamy A. Barathi

    2013-09-01

    Myopia is a huge public health problem worldwide, reaching the highest incidence in Asia. Identification of susceptible genes is crucial for understanding the biological basis of myopia. In this paper, we have identified and characterized a functional myopia-associated gene using a specific mouse-knockout model. Mice lacking the muscarinic cholinergic receptor gene (M2; also known as Chrm2 were less susceptible to lens-induced myopia compared with wild-type mice, which showed significantly increased axial length and vitreous chamber depth when undergoing experimental induction of myopia. The key findings of this present study are that the sclera of M2 mutant mice has higher expression of collagen type I and lower expression of collagen type V than do wild-type mice and mice that are mutant for other muscarinic subtypes, and, therefore, M2 mutant mice were resistant to the development of experimental myopia. Pharmacological blockade of M2 muscarinic receptor proteins retarded myopia progression in the mouse. These results suggest for the first time a role of M2 in growth-related changes in extracellular matrix genes during myopia development in a mammalian model. M2 receptor antagonists might thus provide a targeted therapeutic approach to the management of this refractive error.

  7. Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes

    Science.gov (United States)

    Chimal-Ramírez, G. Karina; Espinoza-Sánchez, Nancy Adriana; Chávez-Sánchez, Luis; Arriaga-Pizano, Lourdes

    2016-01-01

    Macrophages facilitate breast cancer progression. Macrophages were initially classified as M1 or M2 based on their distinct metabolic programs and then expanded to include antitumoral (M1) and protumoral (M2) activities. However, it is still uncertain what markers define the pro- and antitumoral phenotypes and what conditions lead to their formation. In this study, monocytic cell lines and primary monocytes were subjected to commonly reported protocols of M1/M2 polarization and conditions known to engage monocytes into protumoral functions. The results showed that only IDO enzyme and CD86 M1 markers were upregulated correlating with M1 polarization. TNF-α, CCR7, IL-10, arginase I, CD36, and CD163 were expressed indistinguishably from M1 or M2 polarization. Similarly, protumoral engaging resulted in upregulation of both M1 and M2 markers, with conditioned media from the most aggressive breast cancer cell line promoting the greatest changes. In spite of the mixed phenotype, M1-polarized macrophages exhibited the highest expression/secretion of inflammatory mediators, many of which have previously been associated with breast cancer aggressiveness. These data argue that although the existence of protumoral macrophages is unquestionable, their associated phenotypes and the precise conditions driving their formation are still unclear, and those conditions may need both M1 and M2 stimuli. PMID:27376091

  8. Endogenous-Exogenous Money Supply and Trend-Stationary Process of M2——Dynamic growth path analysis of M2%货币供给内生性、外生性与M2退势平稳——M2动态增长路径分析

    Institute of Scientific and Technical Information of China (English)

    徐伟康

    2010-01-01

    本文发现M2是一个退势平稳过程,而非单位根过程.尽管M2具有较强的内生性,但同时也受外生货币政策因素冲击或影响.内生因素和外生因素共同作用使M2围绕一条稳态增长路径上下波动;并且M2偏离稳态增长路径会造成产出波动.于是本文利用2000年至2007年的M2月度数据,分别建立SARMA模型和含月度虚拟变量的组合模型,对这条动态增长路径进行拟合.利用2008年的最新数据评价模型的预测能力时,我们发现M2仍然处在这条动态增长路径上.

  9. Structural and spectroscopic ellipsometry studies on vacuum-evaporated Sn{sub 2m−4}Sb{sub 4}S{sub 2m+2} (m = 2.5, 3 and 4) thin films deposited on glass and Si substrates

    Energy Technology Data Exchange (ETDEWEB)

    Abdelkader, D., E-mail: dhaferabdelkader@gmail.com [Laboratoire de Photovoltaïque et Matériaux Semi-conducteurs-ENIT, Université Tunis ElManar, BP37, Lebelvédère, 1002 Tunis (Tunisia); Akkari, F. Chaffar; Khemiri, N. [Laboratoire de Photovoltaïque et Matériaux Semi-conducteurs-ENIT, Université Tunis ElManar, BP37, Lebelvédère, 1002 Tunis (Tunisia); Gallas, B. [Institut des NanoSciences de Paris-CNRS-Université Pierre et Marie Curie, 4 place Jussieu, 75252 Paris Cedex 05 (France); Antoni, F. [ICube-Laboratoire des sciences de l’Ingénieur, de l' Informatique et de l’Imagerie, Université de Strasbourg-CNRS, 23, rue du Loess, 67037 Strasbourg Cedex (France); Kanzari, M. [Laboratoire de Photovoltaïque et Matériaux Semi-conducteurs-ENIT, Université Tunis ElManar, BP37, Lebelvédère, 1002 Tunis (Tunisia); Institut Préparatoire aux Etudes d' Ingénieurs de Tunis-IPEIT, Université de Tunis, 2, Rue Jawaher Lel Nehru, 1089 Montfleury (Tunisia)

    2015-10-15

    Sn{sub 2m−4}Sb{sub 4}S{sub 2m+2} (m = 2.5, 3 and 4) thin films were deposited on glass and Si substrates using vacuum evaporation technique. The structural properties have been investigated by X-ray diffraction (XRD) and Raman spectroscopy. The XRD patterns revealed the polycrystalline nature of the films on substrates even when they are not heated during evaporation process. Raman spectra revealed four main peaks. The main structural units of Sn–Sb–S thin films are tetrahedral [SnS{sub 4}] and pyramidal [SbS{sub 3}]. The cross-section morphology was obtained by scanning electron microscopy (SEM). Spectroscopic ellipsometry (SE) measurements (ψ and Δ) were carried out to study the optical properties of the films. SE measured data were analyzed by considering double layer optical model for all the samples, with the two oscillators Tauc-Lorentz and Gaussian dispersion relations. Surface roughness was taken into consideration as shown in SEM micrographs. From the ellipsometric study, we determined the thicknesses of the modeled layers and their optical parameters (refractive index, absorption coefficient …). All the films exhibit high absorption coefficient α in the visible range (>10{sup 5} cm{sup −1}). The values of the band gap energy E{sub g} of Sn{sub 2m−4}Sb{sub 4}S{sub 2m+2} thin films deposited on glass were 1.52, 1.29 and 1.28 eV, respectively for m = 2.5, 3 and 4. For the samples deposited on silicon, E{sub g}(SnSb{sub 4}S{sub 7}) = 1.29 eV, E{sub g}(SnSb{sub 2}S{sub 4}) = 1.13 eV and E{sub g}(Sn{sub 2}Sb{sub 2}S{sub 5}) = 1.48 eV. - Highlights: • Sn{sub 2m−4}Sb{sub 4}S{sub 2m+2} films were thermally evaporated on glass and Si substrates. • The films have polycrystalline nature without any heat treatment. • [SnS{sub 4}] tetrahedral and [SbS{sub 3}] pyramidal are the main structural units. • Thicknesses and optical parameters were determined by ellipsometric study. • The films exhibit high absorption coefficient α in the visible

  10. [Heart rate variability study based on a novel RdR RR Intervals Scatter Plot].

    Science.gov (United States)

    Lu, Hongwei; Lu, Xiuyun; Wang, Chunfang; Hua, Youyuan; Tian, Jiajia; Liu, Shihai

    2014-08-01

    On the basis of Poincare scatter plot and first order difference scatter plot, a novel heart rate variability (HRV) analysis method based on scatter plots of RR intervals and first order difference of RR intervals (namely, RdR) was proposed. The abscissa of the RdR scatter plot, the x-axis, is RR intervals and the ordinate, y-axis, is the difference between successive RR intervals. The RdR scatter plot includes the information of RR intervals and the difference between successive RR intervals, which captures more HRV information. By RdR scatter plot analysis of some records of MIT-BIH arrhythmias database, we found that the scatter plot of uncoupled premature ventricular contraction (PVC), coupled ventricular bigeminy and ventricular trigeminy PVC had specific graphic characteristics. The RdR scatter plot method has higher detecting performance than the Poincare scatter plot method, and simpler and more intuitive than the first order difference method.

  11. Computational Drafting of Plot Structures for Russian Folk Tales.

    Science.gov (United States)

    Gervás, Pablo

    The plots of stories are known to follow general patterns in terms of their overall structure. This was the basic tenet of structuralist approaches to narratology. Vladimir Propp proposed a procedure for the generation of new tales based on his semi-formal description of the structure of Russian folk tales. This is one of the first existing instances of a creative process described procedurally. The present paper revisits Propp's morphology to build a system that generates instances of Russian folk tales. Propp's view of the folk tale as a rigid sequence of character functions is employed as a plot driver, and some issues that Propp declared relevant but did not explore in detail-such as long-range dependencies between functions or the importance of endings-are given computational shape in the context of a broader architecture that captures all the aspects discussed by Propp. A set of simple evaluation metrics for the resulting outputs is defined inspired on Propp's formalism. The potential of the resulting system for providing a creative story generation system is discussed, and possible lines of future work are discussed.

  12. Recurrence plot for parameters analysing of internal combustion engine

    Science.gov (United States)

    Alexa, O.; Ilie, C. O.; Marinescu, M.; Vilau, R.; Grosu, D.

    2015-11-01

    In many technical disciplines modem data analysis techniques has been successfully applied to understand the complexity of the system. The growing volume of theoretical knowledge about systems dynamic's offered researchers the opportunity to look for non-linear dynamics in data whose evolution linear models are unable to explain in a satisfactory manner. One approach in this respect is Recurrence Analysis - RA which is a graphical method designed to locate hidden recurring patterns, nonstationarity and structural changes. RA approach arose in natural sciences like physics and biology but quickly was adopted in economics and engineering. Meanwhile. The fast development of computer resources has provided powerful tools to perform this new and complex model. One free software which was used to perform our analysis is Visual Recurrence Analysis - VRA developed by Eugene Kononov. As is presented in this paper, the recurrence plot investigation for the analyzing of the internal combustion engine shows some of the RPA capabilities in this domain. We chose two specific engine parameters measured in two different tests to perform the RPA. These parameters are injection impulse width and engine angular speed and the tests are I11n and I51n. There were computed graphs for each of them. Graphs were analyzed and compared to obtain a conclusion. This work is an incipient research, being one of the first attempts of using recurrence plot for analyzing automotive dynamics. It opens a wide field of action for future research programs.

  13. Dark-lines in bifurcation plots of nonlinear dynamic systems

    Institute of Scientific and Technical Information of China (English)

    Gao Zhi-Ying; Shen Yun-Wen; Liu Meng-Jun

    2005-01-01

    Based on the regressive character of chaotic motion in nonlinear dynamic systems, a numerical regression algorithm is developed, which can be used to research the dark-lines passing through chaotic regions in bifurcation plots. The dark-lines of the parabolic mapping are obtained by using the numerical regression algorithm, and compared with those that are accurately acquired through dark-line equations. Thus the validity of this algorithm is proved. Furthermore,for the Brussel oscillation system and the piecewise linear dynamic system of a gear pair, the dark-lines are researched by using the regression algorithm. By researching the dark-lines in the bifurcation plots of nonlinear dynamic systems,the periodic windows embedded in chaotic regions can be ascertained by tangential points of dark-lines, and the turning points of chaotic attractors can be also obtained by intersected points. The results show that this algorithm is helpful to analyse dynamic behaviour of systems and control chaotic motion.

  14. Evaluating uncertainty in 7Be-based soil erosion estimates: an experimental plot approach

    Science.gov (United States)

    Blake, Will; Taylor, Alex; Abdelli, Wahid; Gaspar, Leticia; Barri, Bashar Al; Ryken, Nick; Mabit, Lionel

    2014-05-01

    Soil erosion remains a major concern for the international community and there is a growing need to improve the sustainability of agriculture to support future food security. High resolution soil erosion data are a fundamental requirement for underpinning soil conservation and management strategies but representative data on soil erosion rates are difficult to achieve by conventional means without interfering with farming practice and hence compromising the representativeness of results. Fallout radionuclide (FRN) tracer technology offers a solution since FRN tracers are delivered to the soil surface by natural processes and, where irreversible binding can be demonstrated, redistributed in association with soil particles. While much work has demonstrated the potential of short-lived 7Be (half-life 53 days), particularly in quantification of short-term inter-rill erosion, less attention has focussed on sources of uncertainty in derived erosion measurements and sampling strategies to minimise these. This poster outlines and discusses potential sources of uncertainty in 7Be-based soil erosion estimates and the experimental design considerations taken to quantify these in the context of a plot-scale validation experiment. Traditionally, gamma counting statistics have been the main element of uncertainty propagated and reported but recent work has shown that other factors may be more important such as: (i) spatial variability in the relaxation mass depth that describes the shape of the 7Be depth distribution for an uneroded point; (ii) spatial variability in fallout (linked to rainfall patterns and shadowing) over both reference site and plot; (iii) particle size sorting effects; (iv) preferential mobility of fallout over active runoff contributing areas. To explore these aspects in more detail, a plot of 4 x 35 m was ploughed and tilled to create a bare, sloped soil surface at the beginning of winter 2013/2014 in southwest UK. The lower edge of the plot was bounded by

  15. Upscaling plot-scale soil respiration in winter wheat and summer maize rotation croplands in Julu County, North China

    Science.gov (United States)

    Huang, Ni; Wang, Li; Guo, Yiqiang; Niu, Zheng

    2017-02-01

    Soil respiration (Rs) data from 45 plots were used to estimate the spatial patterns of Rs during the peak growing seasons of winter wheat and summer maize in Julu County, North China, by combining satellite remote sensing data, field-measured data, and a support vector regression (SVR) model. The observed Rs values were well reproduced by the model at the plot scale, with a root-mean-square error (RMSE) of 0.31 μmol CO2 m-2 s-1 and a coefficient of determination (R2) of 0.73. No significant difference was detected between the prediction accuracy of the SVR model for winter wheat and summer maize. With forcing from satellite remote sensing data and gridded soil property data, we used the SVR model to predict the spatial distributions of Rs during the peak growing seasons of winter wheat and summer maize rotation croplands in Julu County. The SVR model captured the spatial variations of Rs at the county scale. The satellite-derived enhanced vegetation index was found to be the most important input used to predict Rs. Removal of this variable caused an RMSE increase from 0.31 μmol CO2 m-2 s-1 to 0.42 μmol CO2 m-2 s-1. Soil properties such as soil organic carbon (SOC) content and soil bulk density (SBD) were the second most important factors. Their removal led to an RMSE increase from 0.31 μmol CO2 m-2 s-1 to 0.37 μmol CO2 m-2 s-1. The SVR model performed better than multiple regression in predicting spatial variations of Rs in winter wheat and summer maize rotation croplands, as shown by the comparison of the R2 and RMSE values of the two algorithms. The spatial patterns of Rs are better captured using the SVR model than performing multiple regression, particularly for the relatively high and relatively low Rs values at the center and northeast study areas. Therefore, SVR shows promise for predicting spatial variations of Rs values on the basis of remotely sensed data and gridded soil property data at the county scale.

  16. Assessing manure management strategies through small-plot research and whole-farm modeling

    Science.gov (United States)

    Garcia, A.M.; Veith, T.L.; Kleinman, P.J.A.; Rotz, C.A.; Saporito, L.S.

    2008-01-01

    Plot-scale experimentation can provide valuable insight into the effects of manure management practices on phosphorus (P) runoff, but whole-farm evaluation is needed for complete assessment of potential trade offs. Artificially-applied rainfall experimentation on small field plots and event-based and long-term simulation modeling were used to compare P loss in runoff related to two dairy manure application methods (surface application with and without incorporation by tillage) on contrasting Pennsylvania soils previously under no-till management. Results of single-event rainfall experiments indicated that average dissolved reactive P losses in runoff from manured plots decreased by up to 90% with manure incorporation while total P losses did not change significantly. Longer-term whole farm simulation modeling indicated that average dissolved reactive P losses would decrease by 8% with manure incorporation while total P losses would increase by 77% due to greater erosion from fields previously under no-till. Differences in the two methods of inference point to the need for caution in extrapolating research findings. Single-event rainfall experiments conducted shortly after manure application simulate incidental transfers of dissolved P in manure to runoff, resulting in greater losses of dissolved reactive P. However, the transfer of dissolved P in applied manure diminishes with time. Over the annual time frame simulated by whole farm modeling, erosion processes become more important to runoff P losses. Results of this study highlight the need to consider the potential for increased erosion and total P losses caused by soil disturbance during incorporation. This study emphasizes the ability of modeling to estimate management practice effectiveness at the larger scales when experimental data is not available.

  17. Hydrology of small field plots used to study phosphorus runoff under simulated rainfall.

    Science.gov (United States)

    Srinivasan, M S; Kleinman, P J A; Sharpley, A N; Buob, T; Gburek, W J

    2007-01-01

    Use of small plots and rainfall simulators to extrapolate trends in runoff water quality requires careful consideration of hydrologic process represented under such conditions. A modified version of the National Phosphorus Runoff Project (NPRP) protocol was used to assess the hydrology of paired 1 x 2 m plots established on two soils with contrasting hydrologic properties (somewhat poorly drained vs. well drained). Rain simulations (60 mm h(-1)) were conducted to generate 30 min of runoff. For the somewhat poorly drained soil, simulations were conducted in October and May to contrast dry conditions typically targeted by NPRP protocols with wet conditions generally associated with natural runoff. For the well-drained soil, only dry conditions (October) were evaluated. Under dry antecedent moisture conditions, an average of 64 mm of rainfall was applied to the somewhat poorly drained soil to generate 30 min of runoff, as opposed to 96 mm to the well-drained soil. At an extreme, differences in rainfall were equivalent to a 50-yr rainfall-return period. An absence of detectable spatial trends in surface soil moisture suggests uniformity of runoff processes within the plots. No differences in applied rainfall were evident between wet and dry antecedent conditions for the somewhat poorly drained soil. However, significant differences in runoff generation processes were observed in dissolved P concentrations between wet and dry conditions. As natural runoff from the somewhat poorly drained soil is largely under wet antecedent conditions, this study highlights the need for care in interpreting findings from generalized protocols that favor infiltration-excess runoff mechanisms.

  18. Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury.

    Science.gov (United States)

    Hayakawa, Kentaro; Okazaki, Rentaro; Morioka, Kazuhito; Nakamura, Kozo; Tanaka, Sakae; Ogata, Toru

    2014-12-01

    The inflammatory response following spinal cord injury (SCI) has both harmful and beneficial effects; however, it can be modulated for therapeutic benefit. Endotoxin/lipopolysaccharide (LPS) preconditioning, a well-established method for modifying the immune reaction, has been shown to attenuate damage induced by stroke and brain trauma in rodent models. Although such effects likely are conveyed by tissue-repairing functions of the inflammatory response, the mechanisms that control the effects have not yet been elucidated. The present study preconditioned C57BL6/J mice with 0.05 mg/kg of LPS 48 hr before inducing contusion SCI to investigate the effect of LPS preconditioning on the activation of macrophages/microglia. We found that LPS preconditioning promotes the polarization of M1/M2 macrophages/microglia toward an M2 phenotype in the injured spinal cord on quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and immunohistochemical analyses. Flow cytometric analyses reveal that LPS preconditioning facilitates M2 activation in resident microglia but not in infiltrating macrophages. Augmented M2 activation was accompanied by vascularization around the injured lesion, resulting in improvement in both tissue reorganization and functional recovery. Furthermore, we found that M2 activation induced by LPS preconditioning is regulated by interleukin-10 gene expression, which was preceded by the transcriptional activation of interferon regulatory factor (IRF)-3, as demonstrated by Western blotting and an IRF-3 binding assay. Altogether, our findings demonstrate that LPS preconditioning has a therapeutic effect on SCI through the modulation of M1/M2 polarization of resident microglia. The present study suggests that controlling M1/M2 polarization through endotoxin signal transduction could become a promising therapeutic strategy for various central nervous system diseases. © 2014 Wiley Periodicals, Inc.

  19. Information extraction from FN plots of tungsten microemitters

    Energy Technology Data Exchange (ETDEWEB)

    Mussa, Khalil O. [Department of Physics, Mu' tah University, Al-Karak (Jordan); Mousa, Marwan S., E-mail: mmousa@mutah.edu.jo [Department of Physics, Mu' tah University, Al-Karak (Jordan); Fischer, Andreas, E-mail: andreas.fischer@physik.tu-chemnitz.de [Institut für Physik, Technische Universität Chemnitz, Chemnitz (Germany)

    2013-09-15

    Tungsten based microemitter tips have been prepared both clean and coated with dielectric materials. For clean tungsten tips, apex radii have been varied ranging from 25 to 500 nm. These tips were manufactured by electrochemical etching a 0.1 mm diameter high purity (99.95%) tungsten wire at the meniscus of two molar NaOH solution. Composite micro-emitters considered here are consisting of a tungsten core coated with different dielectric materials—such as magnesium oxide (MgO), sodium hydroxide (NaOH), tetracyanoethylene (TCNE), and zinc oxide (ZnO). It is worthwhile noting here, that the rather unconventional NaOH coating has shown several interesting properties. Various properties of these emitters were measured including current–voltage (IV) characteristics and the physical shape of the tips. A conventional field emission microscope (FEM) with a tip (cathode)–screen (anode) separation standardized at 10 mm was used to electrically characterize the electron emitters. The system was evacuated down to a base pressure of ∼10{sup −8}mbar when baked at up to ∼180°C overnight. This allowed measurements of typical field electron emission (FE) characteristics, namely the IV characteristics and the emission images on a conductive phosphorus screen (the anode). Mechanical characterization has been performed through a FEI scanning electron microscope (SEM). Within this work, the mentioned experimental results are connected to the theory for analyzing Fowler–Nordheim (FN) plots. We compared and evaluated the data extracted from clean tungsten tips of different radii and determined deviations between the results of different extraction methods applied. In particular, we derived the apex radii of several clean and coated tungsten tips by both SEM imaging and analyzing FN plots. The aim of this analysis is to support the ongoing discussion on recently developed improvements of the theory for analyzing FN plots related to metal field electron emitters, which in

  20. Tumor type M2 pyruvate kinase expression in gastric cancer,colorectal cancer and controls

    Institute of Scientific and Technical Information of China (English)

    Bo Zhang; Jian-Ying Chen; Dao-Da Chen; Guo-Bin Wang; Ping Shen

    2004-01-01

    AIM: Tumor formation is generally linked to an expansion of glycolytic phosphometabolite pools and aerobic glycolytic flux rates. To achieve this, tumor cells generally overexpress a special glycolytic isoenzyme, termed pyruvate kinase type M2. The present study was designed to evaluate the use of a new tumor marker, tumor M2-PK, in discriminating gastrointestinal cancer patients from healthy controls, and to compare with the reference tumor markers CEA and CA72-4.METHODS: The concentration of tumor M2-PK in body fluids could be quantitatively determined by a commercially available enzyme-linked immunosorbent assay (ELISA)-kit (ScheBo(R) Tech, Giessen, Germany). By using this kit, the tumor M2-PK concentration was measured in EDTA-plasma of 108 patients. For the healthy blood donors a cut-off value of 15 U/mL was evaluated, which corresponded to 90% specificity. Overall 108 patients were included in this study, 54 patients had a histological confirmed gastric cancer, 54 patients colorectal cancer, and 20 healthy volunteers served as controls.RESULTS: The cut-off value to discriminate patients from controls was established at 15 U/mL for tumor M2-PK. The mean tumor M2-PK concentration of gastric cancer was 26.937 U/mL. According to the TNM stage system, the mean tumor M2-PK concentration of stage Ⅰ was 16.324 U/mL, of stage Ⅱ 15.290 U/mL, of stage Ⅲ 30.289 U/mL, of stage Ⅳ127.31 U/mL, of non-metastasis 12.854 U/mL and of metastasis 35.711 U/mL. The mean Tumor M2-PK concentration of colorectal cancer was 30.588 U/mL. According to the Dukes stage system, the mean tumor M2-PK concentration of Dukes A was 16.638 U/mL, of Dukes B 22.070 U/mL, and of Dukes C 48.024 U/mL, of non-metastasis 19.501 U/mL, of metastasis 49.437 U/mL. The mean tumor M2-PK concentration allowed a significant discrimination of colorectal cancers (30.588 U/mL) from controls (10.965 U/mL) (P<0.01), and gastric cancer (26.937 U/mL) from controls (10.965 U/mL)(P<0.05). The overall

  1. Technological Transformation Practice of 105 m2 Sintering Machine%105 m2烧结机技术改造实践

    Institute of Scientific and Technical Information of China (English)

    白玮

    2015-01-01

    山钢股份莱芜分公司炼铁厂对3台105 m2烧结机进行了一系列技术改造,包括烧结熔剂破碎工艺优化,配料自动化控制系统改造,混合料温度提升,混合机筒体衬板及安装改造,烧结机漏风治理,单辊篦板保护帽改造等。改造后,烧结机作业率98.02%,烧结矿合格率98.19%,产量355.9万t。%A series of technological transformation for three 105 m2 sintering machines in Laiwu branch iron works has been made. That include to optimize sintering flux crushing process and transform automatic batching control, increase the temperature of mixture, reform of mixing machine barrel lining board and installation, control the air leakage of sinter, transform the single and grate plate protective cap. The sintering machine operating rate reached 98.02%, sinter and the qualified rate can reach 98.19%, sinter yield reached 355.9 million tons.

  2. 羊八井50m2 RPC地毯性能研究%Study on the Performance of YBJ 50m2 RPC Carpet

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    利用羊八井50m2 RPC地毯(YBJ-ARGO实验原型)的测试数据对其性能进行了分析研究,包括原初粒子方位角分布、天顶角分布、地毯的角分辨、探测时间系统误差对方位角分布的正弦调制、探测时间系统误差的离线修正、几何不对称的小型地毯探测器上原初粒子到达方向重建误差造成的方位角分布的不均匀性等.%The characteristics of a 50m2 RPC carpet(prototype of YBJ-ARGO experiment)was analyzed using its test run data.A correction method of the systematic time error is suggested,and non-uniform azimuthal angle distribution possibly due to direction reconstruction error on an asymmetric carpet is reported.

  3. Dynamic Changes of Microglia/Macrophage M1 and M2 Polarization in Theiler's Murine Encephalomyelitis.

    Science.gov (United States)

    Herder, Vanessa; Iskandar, Cut Dahlia; Kegler, Kristel; Hansmann, Florian; Elmarabet, Suliman Ahmed; Khan, Muhammad Akram; Kalkuhl, Arno; Deschl, Ulrich; Baumgärtner, Wolfgang; Ulrich, Reiner; Beineke, Andreas

    2015-11-01

    Microglia and macrophages play a central role for demyelination in Theiler's murine encephalomyelitis (TME) virus infection, a commonly used infectious model for chronic-progressive multiple sclerosis. In order to determine the dynamic changes of microglia/macrophage polarization in TME, the spinal cord of Swiss Jim Lambert (SJL) mice was investigated by gene expression profiling and immunofluorescence. Virus persistence and demyelinating leukomyelitis were confirmed by immunohistochemistry and histology. Electron microscopy revealed continuous myelin loss together with abortive myelin repair during the late chronic infection phase indicative of incomplete remyelination. A total of 59 genes out of 151 M1- and M2-related genes were differentially expressed in TME virus-infected mice over the study period. The onset of virus-induced demyelination was associated with a dominating M1 polarization, while mounting M2 polarization of macrophages/microglia together with sustained prominent M1-related gene expression was present during the chronic-progressive phase. Molecular results were confirmed by immunofluorescence, showing an increased spinal cord accumulation of CD16/32(+) M1-, arginase-1(+) M2- and Ym1(+) M2-type cells associated with progressive demyelination. The present study provides a comprehensive database of M1-/M2-related gene expression involved in the initiation and progression of demyelination supporting the hypothesis that perpetuating interaction between virus and macrophages/microglia induces a vicious circle with persistent inflammation and impaired myelin repair in TME.

  4. Beam quality M 2 factor matrix for non-circular symmetric laser beams

    Science.gov (United States)

    Du, Yongzhao; Fu, Yuqing; Zheng, Chaoying

    2017-02-01

    It is standard to use Mx2 and My2 to characterize the beam quality of a non-circular symmetrical beam on its x-axis and y-axis orientation. However, we knew that the values of Mx2 and My2 are inconsistent if one selects a different coordinate system or measures beam quality with different experimental conditionals, even when analyzing the same beam. To overcome this, a new beam quality characterization method, the M 2 factor matrix, is developed. It not only contains the beam quality terms, Mx2 and My2 , to characterize the beam quality along x-axis and y-axis orientation for the non-symmetric beam, but also introduces two additional cross terms, M xy and M yx , which are used to characterize the location relationship between the principal axis of the test beam and coordinate system in experiment. Moreover, M 2 factor matrix can be measured with a similar procedure to the traditional M 2 factor whose measurement instructions are described in ISO11146 by adding some additional image and signal processing procedure. The measurement principle and method is present and the experiment system for beam quality M 2 factor matrix is built to demonstrate the performance of M 2 factor matrix with real experiments.

  5. Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.

    Science.gov (United States)

    Tang, Yu; Le, Weidong

    2016-03-01

    One of the most striking hallmarks shared by various neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis, is microglia-mediated neuroinflammation. Increasing evidence indicates that microglial activation in the central nervous system is heterogeneous, which can be categorized into two opposite types: M1 phenotype and M2 phenotype. Depending on the phenotypes activated, microglia can produce either cytotoxic or neuroprotective effects. In this review, we focus on the potential role of M1 and M2 microglia and the dynamic changes of M1/M2 phenotypes that are critically associated with the neurodegenerative diseases. Generally, M1 microglia predominate at the injury site at the end stage of disease, when the immunoresolution and repair process of M2 microglia are dampened. This phenotype transformation is very complicated in AD due to the phagocytosis of regionally distributed β-amyloid (Aβ) plaque and tangles that are released into the extracellular space. The endogenous stimuli including aggregated α-synuclein, mutated superoxide dismutase, Aβ, and tau oligomers exist in the milieu that may persistently activate M1 pro-inflammatory responses and finally lead to irreversible neuron loss. The changes of microglial phenotypes depend on the disease stages and severity; mastering the stage-specific switching of M1/M2 phenotypes within appropriate time windows may provide better therapeutic benefit.

  6. Large-Scale Mini-Magnetosphere Plasma Propulsion (M2P2) Experiments

    Science.gov (United States)

    Winglee, R. M.; Slough, J.; Ziemba, T.; Euripides, P.; Adrian, M. L.; Gallagher, D.; Craven, P.; Tomlinson, W.; Cravens, J.; Burch, J.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    Mini-Magnetosphere Plasma Propulsion (M2P2) is an innovative plasma propulsion system that has the potential to propel spacecraft at unprecedented speeds of 50 to 80 km per second with a low-power requirement of approx. 1 kW per 100 kg of payload and approx. 1 kg of neutral gas [fuel] consumption per day of acceleration. Acceleration periods from several days to a few months are envisioned. High specific impulse and efficiency are achieved through coupling of the spacecraft to the 400 km per second solar wind through an artificial magnetosphere. The mini-magnetosphere or inflated magnetic bubble is produced by the injection of cold dense plasma into a spacecraft-generated magnetic field envelope. Magnetic bubble inflation is driven by electromagnetic processes thereby avoiding the material and deployment problems faced by mechanical solar sail designs, Here, we present the theoretical design of M2P2 as well as initial results from experimental testing of an M2P2 prototype demonstrating: 1) inflation of the dipole magnetic field geometry through the internal injection of cold plasma; and 2) deflection of and artificial solar wind by the prototype M2P2 system. In addition, we present plans for direct laboratory measurement of thrust imparted to a prototype M2P2 by an artificial solar wind during the summer of 2001.

  7. Three-dimensional numerical simulation of M2 internal tides in the Luzon Strait

    Institute of Scientific and Technical Information of China (English)

    LI Bingtian; CAO Anzhou; LV Xianqing

    2015-01-01

    A three-dimensional isopycnic-coordinate internal tidal model is employed to investigate the generation, propagation, vertical structure and energy conversion of M2 internal tides in the Luzon Strait (LS) with mooring observations. Simulated results, especially the tidal current amplitudes, agree well with observations, demonstrating the reasonability and accuracy of the model. Results indicate that M2 internal tides mainly propagate into three directions horizontally, i.e., eastward towards the western Pacific Ocean, westward towards the Dongsha Island and southwestward towards the South China Sea Basin. In the horizontal direction, tidal current amplitudes decrease as distance increases away from the LS; in the vertical direction, they show an obvious decreasing tendency with depth. Between the double ridges of the LS, a clockwise gyre of M2 baroclinic energy flux appears, which is caused by reflections of M2 internal tides at supercritical topographies, and resonance of M2 internal tides happens along 19.5° and 21.5°N due to the heights and separation distance of the double ridges. The total energy conversion in the LS is about 14.20 GW.

  8. Estimates of global M2 internal tide energy fluxes using TOPEX/POSEIDON altimeter data

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yanwei; LIANG Xinfeng; TIAN Jiwei; YANG Lifen

    2009-01-01

    TOPEX/POSEIDON altimeter data from October 1992 to June 2002 are used to calculate the global barotropic M2 tidal currents using long-term tidal harmonic analysis. The tides calculated agree well with ADCP data obtained from the South China Sea (SCS). The maximum tide velocities along the semi-major axis and semi-minor axis can be computed from the tidal ellipse. The global distribution of M2 internal tide vertical energy flux from the sea bottom is calculated based on a linear internal wave generation model. The global vertical energy flux of M2 internal tide is 0.96 TW, with 0.36 TW in the Pacific, 0.31 TW in the Atlantic and 0.29 TW in the Indian Ocean, obtained in this study. The total horizontal energy flux of M2 internal tide radiating into the open ocean from the lateral boundaries is 0.13 TW, with 0.06 TW in the Pacific, 0.04TW in the Atlantic, and 0.03 TW in the Indian Ocean. The result shows that the principal lunar semi-diurnal tide M2 provides enough energy to maintain the large-scale thermohaline circulation of the ocean.

  9. Dynamic Environmental/Economic Scheduling for Microgrid Using Improved MOEA/D-M2M

    Directory of Open Access Journals (Sweden)

    Xin Li

    2016-01-01

    Full Text Available The environmental/economic dynamic scheduling for microgrids (MGs is a complex multiobjective optimization problem, which usually has dynamic system parameters and constraints. In this paper, a biobjective optimization model of MG scheduling is established. And various types of microsources (like the conventional sources, various types of renewable sources, etc., electricity markets, and dynamic constraints are considered. A recently proposed MOEA/D-M2M framework is improved (I-MOEA/D-M2M to solve the real-world MG scheduling problems. In order to deal with the constraints, the processes of solutions sorting and selecting in the original MOEA/D-M2M are revised. In addition, a self-adaptive decomposition strategy and a modified allocation method of individuals are introduced to enhance the capability of dealing with uncertainties, as well as reduce unnecessary computational work in practice and meet the time requirements for the dynamic optimization tasks. Thereafter, the proposed I-MOEA/D-M2M is applied to the independent MG scheduling problems, taking into account the load demand variation and the electricity price changes. The simulation results by MATLAB show that the proposed method can achieve better distributed fronts in much less running time than the typical multiobjective evolutionary algorithms (MOEAs like the improved strength Pareto evolutionary algorithm (SPEA2 and the nondominated sorting genetic algorithm II (NSGAII. Finally, I-MOEA/D-M2M is used to solve a 24-hour MG dynamic operation scheduling problem and obtains satisfactory results.

  10. Structural environment built by AKAP12+ colon mesenchymal cells drives M2 macrophages during inflammation recovery

    Science.gov (United States)

    Yang, Jun-Mo; Lee, Hye Shin; Seo, Ji Hae; Park, Ji-Hyeon; Gelman, Irwin H.; Lo, Eng H.; Kim, Kyu-Won

    2017-01-01

    Macrophages exhibit phenotypic plasticity, as they have the ability to switch their functional phenotypes during inflammation and recovery. Simultaneously, the mechanical environment actively changes. However, how these dynamic alterations affect the macrophage phenotype is unknown. Here, we observed that the extracellular matrix (ECM) constructed by AKAP12+ colon mesenchymal cells (CMCs) generated M2 macrophages by regulating their shape during recovery. Notably, rounded macrophages were present in the linear and loose ECM of inflamed colons and polarized to the M1 phenotype. In contrast, ramified macrophages emerged in the contracted ECM of recovering colons and mainly expressed M2 macrophage markers. These contracted structures were not observed in the inflamed colons of AKAP12 knockout (KO) mice. Consequently, the proportion of M2 macrophages in inflamed colons was lower in AKAP12 KO mice than in WT mice. In addition, clinical symptoms and histological damage were more severe in AKAP12 KO mice than in WT mice. In experimentally remodeled collagen gels, WT CMCs drove the formation of a more compacted structure than AKAP12 KO CMCs, which promoted the polarization of macrophages toward an M2 phenotype. These results demonstrated that tissue contraction during recovery provides macrophages with the physical cues that drive M2 polarization. PMID:28205544

  11. Wireless Access Control with Smart Antenna for M2M Communications

    Science.gov (United States)

    Sakamoto, Hiroshi; Bandai, Masaki; Watanabe, Takashi

    Machine to machine (M2M) is a promising technology to achieve an ubiquitous environment by uniting machines and machines over the Internet. The network used for M2M consists of core network and access network. This paper discusses effective controls of the wireless access network for M2M. Among typical examples of the wireless access network for M2M is a wireless sensor network (WSN). WSN for M2M may require energy efficiency, high reliability and throughput. For these requirements, in this paper, we propose a scheme to build a hierarchical sensor network using smart antenna. The proposed scheme uses omni-directional antennas together with smart antennas. Since smart antennas can extend communications distance, the proposed scheme enables reduction of number of hops to reduce the traffic load on relay nodes. As a result, the energy consumption, data collection ratio and throughput can be improved. We implement the proposed scheme on a real testbed. The testbed uses UNAGI as smart antenna nodes and Mica Mote as sensor nodes. In addition to the fundamental evaluation on the testbed, we simulate large-scale sensor networks. The results show the effectiveness of the proposed hierarchical sensor network with smart antennas.

  12. Modelling packing interactions in parallel helix bundles: pentameric bundles of nicotinic receptor M2 helices.

    Science.gov (United States)

    Sankararamakrishnan, R; Sansom, M S

    1995-11-01

    The transbilayer pore of the nicotinic acetylcholine receptor (nAChR) is formed by a pentameric bundle of M2 helices. Models of pentameric bundles of M2 helices have been generated using simulated annealing via restrained molecular dynamics. The influence of: (a) the initial C alpha template; and (b) screening of sidechain electrostatic interactions on the geometry of the resultant M2 helix bundles is explored. Parallel M2 helices, in the absence of sidechain electrostatic interactions, pack in accordance with simple ridges-in-grooves considerations. This results in a helix crossing angle of ca. +12 degrees, corresponding to a left-handed coiled coil structure for the bundle as a whole. Tilting of M2 helices away from the central pore axis at their C-termini and/or inclusion of sidechain electrostatic interactions may perturb such ridges-in-grooves packing. In the most extreme cases right-handed coiled coils are formed. An interplay between inter-helix H-bonding and helix bundle geometry is revealed. The effects of changes in electrostatic screening on the dimensions of the pore mouth are described and the significance of these changes in the context of models for the nAChR pore domain is discussed.

  13. The challenges of M2M massive access in wireless cellular networks

    Directory of Open Access Journals (Sweden)

    Andrea Biral

    2015-02-01

    Full Text Available The next generation of communication systems, which is commonly referred to as 5G, is expected to support, besides the traditional voice and data services, new communication paradigms, such as Internet of Things (IoT and Machine-to-Machine (M2M services, which involve communication between Machine-Type Devices (MTDs in a fully automated fashion, thus, without or with minimal human intervention. Although the general requirements of 5G systems are progressively taking shape, the technological issues raised by such a vision are still partially unclear. Nonetheless, general consensus has been reached upon some specific challenges, such as the need for 5G wireless access networks to support massive access by MTDs, as a consequence of the proliferation of M2M services. In this paper, we describe the main challenges raised by the M2M vision, focusing in particular on the problems related to the support of massive MTD access in current cellular communication systems. Then we analyze the most common approaches proposed in the literature to enable the coexistence of conventional and M2M services in the current and next generation of cellular wireless systems. We finally conclude by pointing out the research challenges that require further investigation in order to provide full support to the M2M paradigm.

  14. Dalitz plot analysis of the D+ -> K- pi+ pi+ decay

    CERN Document Server

    Bonvicini, G; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Naik, P; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Eisenstein, B I; Karliner, I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A G; Ecklund, K M; Love, W; Savinov, V; López, A; Mehrabyan, S; Méndez, H; Ramírez, J; Ge, J Y; Miller, D H; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Horwitz, N; Khalil, S; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M

    2007-01-01

    We present a Dalitz plot analysis of the decay D+ -> K- pi+ pi+ based on 281 pb-1 of e+e- collision data produced at the psi(3770) by CESR and observed with the CLEO-c detector. We select 67086 candidate events with a small, ~1.1%, background for this analysis. When using a simple isobar model our results are consistent with the previous measurements done by E791. Since our sample is considerably larger we can explore alternative models. We find better agreement with data when we include an isospin-two pi+pi+ S-wave contribution. We apply a quasi model-independent partial wave analysis and measure the amplitude and phase of the K pi and pi+pi+ S waves in the range of invariant masses from the threshold to the maximum in this decay.

  15. Dalitz Plot Analysis of Ds+->pi+pi-pi+

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.; Bona, M.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Lopez, L.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Abrams, G.S.; Battaglia, M.; Brown, D.N.; Cahn, R.N.; Jacobsen, R.G.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DSM, DAPNIA, Saclay /South Carolina U. /SLAC /Stanford U., Phys. Dept. /SUNY, Albany /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-01-26

    A Dalitz plot analysis of {approx} 13, 000 D{sub s}{sup +} decays to {pi}{sup +}{pi}{sup +}{pi}{sup -} has been performed. A 384 fb{sup -1} data sample, recorded by the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} storage ring running at center of mass energies near 10.6 GeV, is used. Amplitudes and phases of the intermediate resonances which contribute to this final state are measured. A high precision measurement of the ratio: {Beta}(D{sub s}{sup +} {yields} {pi}{sup +}{pi}{sup +}{pi}{sup -})/{Beta}(D{sub s}{sup +} {yields} K{sup +}K{sup -}{pi}{sup +}) = 0.199 {+-} 0.004 {+-} 0.006 is performed. Using a model independent partial wave analysis the amplitude and phase of the S-wave have been measured.

  16. Dalitz plot analysis of Ds+→π+π-π+

    Science.gov (United States)

    Aubert, B.; Bona, M.; Karyotakis, Y.; Lees, J. P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Lopez, L.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Abrams, G. S.; Battaglia, M.; Brown, D. N.; Jacobsen, R. G.; Kerth, L. T.; Kolomensky, Yu. G.; Lynch, G.; Osipenkov, I. L.; Ronan, M. T.; Tackmann, K.; Tanabe, T.; Hawkes, C. M.; Soni, N.; Watson, A. T.; Koch, H.; Schroeder, T.; Asgeirsson, D. J.; Fulsom, B. G.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; Barrett, M.; Khan, A.; Blinov, V. E.; Bukin, A. D.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Bondioli, M.; Curry, S.; Eschrich, I.; Kirkby, D.; Lankford, A. J.; Lund, P.; Mandelkern, M.; Martin, E. C.; Stoker, D. P.; Abachi, S.; Buchanan, C.; Atmacan, H.; Gary, J. W.; Liu, F.; Long, O.; Vitug, G. M.; Yasin, Z.; Zhang, L.; Sharma, V.; Campagnari, C.; Hong, T. M.; Kovalskyi, D.; Mazur, M. A.; Richman, J. D.; Beck, T. W.; Eisner, A. M.; Flacco, C. J.; Heusch, C. A.; Kroseberg, J.; Lockman, W. S.; Martinez, A. J.; Schalk, T.; Schumm, B. A.; Seiden, A.; Wilson, M. G.; Winstrom, L. O.; Cheng, C. H.; Doll, D. A.; Echenard, B.; Fang, F.; Hitlin, D. G.; Narsky, I.; Piatenko, T.; Porter, F. C.; Andreassen, R.; Mancinelli, G.; Meadows, B. T.; Mishra, K.; Sokoloff, M. D.; Bloom, P. C.; Ford, W. T.; Gaz, A.; Hirschauer, J. F.; Nagel, M.; Nauenberg, U.; Smith, J. G.; Wagner, S. R.; Ayad, R.; Soffer, A.; Toki, W. H.; Wilson, R. J.; Feltresi, E.; Hauke, A.; Jasper, H.; Karbach, M.; Merkel, J.; Petzold, A.; Spaan, B.; Wacker, K.; Kobel, M. J.; Nogowski, R.; Schubert, K. R.; Schwierz, R.; Volk, A.; Bernard, D.; Bonneaud, G. R.; Latour, E.; Verderi, M.; Clark, P. J.; Playfer, S.; Watson, J. E.; Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Santoro, V.; Baldini-Ferroli, R.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Pacetti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Buzzo, A.; Contri, R.; Lo Vetere, M.; Macri, M. M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Tosi, S.; Chaisanguanthum, K. S.; Morii, M.; Adametz, A.; Marks, J.; Schenk, S.; Uwer, U.; Bernlochner, F. U.; Klose, V.; Lacker, H. M.; Bard, D. J.; Dauncey, P. D.; Tibbetts, M.; Behera, P. K.; Chai, X.; Charles, M. J.; Mallik, U.; Cochran, J.; Crawley, H. B.; Dong, L.; Meyer, W. T.; Prell, S.; Rosenberg, E. I.; Rubin, A. E.; Gao, Y. Y.; Gritsan, A. V.; Guo, Z. J.; Lae, C. K.; Arnaud, N.; Béquilleux, J.; D'Orazio, A.; Davier, M.; Firmino da Costa, J.; Grosdidier, G.; Le Diberder, F.; Lepeltier, V.; Lutz, A. M.; Pruvot, S.; Roudeau, P.; Schune, M. H.; Serrano, J.; Sordini, V.; Stocchi, A.; Wormser, G.; Lange, D. J.; Wright, D. M.; Bingham, I.; Burke, J. P.; Chavez, C. A.; Fry, J. R.; Gabathuler, E.; Gamet, R.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Clarke, C. K.; di Lodovico, F.; Sacco, R.; Sigamani, M.; Cowan, G.; Paramesvaran, S.; Wren, A. C.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Fritsch, M.; Gradl, W.; Alwyn, K. E.; Bailey, D.; Barlow, R. J.; Jackson, G.; Lafferty, G. D.; West, T. J.; Yi, J. I.; Anderson, J.; Chen, C.; Jawahery, A.; Roberts, D. A.; Simi, G.; Tuggle, J. M.; Dallapiccola, C.; Li, X.; Salvati, E.; Saremi, S.; Cowan, R.; Dujmic, D.; Fisher, P. H.; Henderson, S. W.; Sciolla, G.; Spitznagel, M.; Taylor, F.; Yamamoto, R. K.; Zhao, M.; Patel, P. M.; Robertson, S. H.; Lazzaro, A.; Lombardo, V.; Palombo, F.; Bauer, J. M.; Cremaldi, L.; Godang, R.; Kroeger, R.; Summers, D. J.; Zhao, H. W.; Simard, M.; Taras, P.; Nicholson, H.; de Nardo, G.; Lista, L.; Monorchio, D.; Onorato, G.; Sciacca, C.; Raven, G.; Snoek, H. L.; Jessop, C. P.; Knoepfel, K. J.; Losecco, J. M.; Wang, W. F.; Corwin, L. A.; Honscheid, K.; Kagan, H.; Kass, R.; Morris, J. P.; Rahimi, A. M.; Regensburger, J. J.; Sekula, S. J.; Wong, Q. K.; Blount, N. L.; Brau, J.; Frey, R.; Igonkina, O.; Kolb, J. A.; Lu, M.; Rahmat, R.; Sinev, N. B.; Strom, D.; Strube, J.; Torrence, E.; Castelli, G.; Gagliardi, N.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Voci, C.; Del Amo Sanchez, P.; Ben-Haim, E.; Briand, H.; Calderini, G.; Chauveau, J.; Hamon, O.; Leruste, Ph.; Ocariz, J.; Perez, A.; Prendki, J.; Sitt, S.; Gladney, L.; Biasini, M.; Manoni, E.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Cervelli, A.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Morganti, M.; Neri, N.; Paoloni, E.; Rizzo, G.; Walsh, J. J.; Lopes Pegna, D.; Lu, C.; Olsen, J.; Smith, A. J. S.; Telnov, A. V.; Anulli, F.; Baracchini, E.; Cavoto, G.; Faccini, R.; Ferrarotto, F.; Ferroni, F.

    2009-02-01

    A Dalitz plot analysis of approximately 13 000 Ds+ decays to π+π-π+ has been performed. The analysis uses a 384fb-1 data sample recorded by the BABAR detector at the PEP-II asymmetric-energy e+e- storage ring running at center of mass energies near 10.6 GeV. Amplitudes and phases of the intermediate resonances which contribute to this final state are measured. A high precision measurement of the ratio of branching fractions is performed: B(Ds+→π+π-π+)/B(Ds+→K+K-π+)=0.199±0.004±0.009. Using a model-independent partial wave analysis, the amplitude and phase of the S wave have been measured.

  17. Multiscale recurrence quantification analysis of order recurrence plots

    Science.gov (United States)

    Xu, Mengjia; Shang, Pengjian; Lin, Aijing

    2017-03-01

    In this paper, we propose a new method of multiscale recurrence quantification analysis (MSRQA) to analyze the structure of order recurrence plots. The MSRQA is based on order patterns over a range of time scales. Compared with conventional recurrence quantification analysis (RQA), the MSRQA can show richer and more recognizable information on the local characteristics of diverse systems which successfully describes their recurrence properties. Both synthetic series and stock market indexes exhibit their properties of recurrence at large time scales that quite differ from those at a single time scale. Some systems present more accurate recurrence patterns under large time scales. It demonstrates that the new approach is effective for distinguishing three similar stock market systems and showing some inherent differences.

  18. Recurrence plots of discrete-time Gaussian stochastic processes

    Science.gov (United States)

    Ramdani, Sofiane; Bouchara, Frédéric; Lagarde, Julien; Lesne, Annick

    2016-09-01

    We investigate the statistical properties of recurrence plots (RPs) of data generated by discrete-time stationary Gaussian random processes. We analytically derive the theoretical values of the probabilities of occurrence of recurrence points and consecutive recurrence points forming diagonals in the RP, with an embedding dimension equal to 1. These results allow us to obtain theoretical values of three measures: (i) the recurrence rate (REC) (ii) the percent determinism (DET) and (iii) RP-based estimation of the ε-entropy κ(ε) in the sense of correlation entropy. We apply these results to two Gaussian processes, namely first order autoregressive processes and fractional Gaussian noise. For these processes, we simulate a number of realizations and compare the RP-based estimations of the three selected measures to their theoretical values. These comparisons provide useful information on the quality of the estimations, such as the minimum required data length and threshold radius used to construct the RP.

  19. B^0 --> K^+ \\pi^- \\pi^0 Dalitz Plot Analysis

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, Roy; Allison, J; Allmendinger, T; Altenburg, D; Andreotti, M; Angelini, C; Anulli, F; Aston, D; Azzolini, V; Baak, M; Back, J J; Bailey, S; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Barate, R; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Bauer, J M; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Berger, N; Bernard, D; Berryhill, J W; Best, D; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bianchi, F; Biasini, M; Blanc, F; Blaylock, G; Blinov, A E; Blinov, V E; Bloom, P; Bóna, M; Bondioli, M; Bonneaud, G R; Borgland, A W; Bosisio, L; Boutigny, D; Bowerman, D A; Boyarski, A M; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Breon, A B; Briand, H; Brochard, F; Brose, J; Brown, C L; Brown, C M; Brown, D; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Buchmüller, O L; Bugg, W; Bulten, H; Burchat, Patricia R; Button-Shafer, J; Buzzo, A; Côté, D; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Capra, R; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, E; Chen, J C; Chen, S; Cheng, B; Cheng, C H; Chevalier, N; Christ, S; Cibinetto, G; Clark, P J; Claus, R; Cochran, J; Colecchia, F; Coleman, J P; Contri, R; Convery, M R; Cormack, C M; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L M; Cristinziani, M; Crosetti, G; Çuhadar-Dönszelmann, T; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; Day, C T; De Groot, N; De Nardo, Gallieno; Del Buono, L; Della Ricca, G; Di Lodovico, F; Dickopp, M; Dittongo, S; Dong, D; Dorfan, J; Dorigo, A; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Eckmann, R; Edwards, A J; Egede, U; Eichenbaum, A M; Eigen, G; Eisner, A M; Elmer, P; Elsen, E E; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Fabozzi, F; Faccini, R; Fan, S; Farbin, A; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B J; Frey, R; Fritsch, M; Fry, J R; Gabathuler, Erwin; Gaidot, A; Gaillard, J M; Gaillard, J R; Galeazzi, F; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gary, J W; Gaspero, M; Gatto, C; Geddes, N I; Gill, M S; Giorgi, M A; Giraud, P F; Giroux, X; Gladney, L; Glanzman, T; Godang, R; Goetzen, K; Golubev, V B; Gopal, G P; Gowdy, S J; Graham, M; Grancagnolo, S; Green, M G; Greene, M G; Grenier, G J; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Q H; Hadavand, H K; Hadig, T; Haire, M; Halyo, V; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hart, P A; Hartfiel, B L; Harton, J L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hicheur, A; Hill, E J; Hitlin, D G; Höcker, A; Hodgkinson, M C; Hollar, J J; Honscheid, K; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Igonkina, O; Innes, W R; Ivanchenko, V N; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jawahery, A; Jayatilleke, S M; Jessop, C P; John, M J J; Johnson, J R; Judd, D; Kadel, R W; Kadyk, J; Kagan, H; Karyotakis, Yu; Kass, R; Kelly, M P; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Kitayama, I; Knecht, N S; Koch, H; Kocian, M L; Kofler, R; Kolomensky, Yu G; Koptchev, V B; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kravchenko, E A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; Lacker, H M; Lae, C K; Lafferty, G D; Lamsa, J; Lanceri, L; Lange, D J; Langenegger, U; Lankford, A J; Laplace, S; Latham, T E; Lau, Y P; Lavin, D; Lazzaro, A; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, H; Libby, J; Lillard, V; Lista, L; Liu, R; LoSecco, J M; Lo Vetere, M; Lockman, W S; Lombardo, V; London, G W; Long, O; Lou, X C; Lu, A; Lü, C; Luitz, S; Luppi, E; Lusiani, A; Lüth, V; Lutz, A M; Lynch, G; Lynch, H L; Lyon, A J; MacFarlane, D B; Macri, M; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Manfredi, P F; Mangeol, D J J; Marchiori, G; Margoni, M; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mayer, B; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Meadows, B T; Messner, R; Meyer, T I; Meyer, W T; Miftakov, V; Mihályi, A; Mir, L M; Mohanty, G B; Mohapatra, A K; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morgan, S E; Morganti, M; Morganti, S; Morii, M; Morton, G W; Muheim, F; Müller, D R; Müller-Pfefferkorn, R; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nesom, G; Nicholson, H; Nikolich, M B; Nogowski, R; O'Grady, C P; Ocariz, J; Oddone, P J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Otto, S; Ozcan, V E; Paar, H P; Paick, K; Palano, A; Palombo, F; Pan, Y; Panetta, J; Panvini, R S; Paoloni, E; Paolucci, P; Parry, R J; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, I M; Petersen, B A; Petersen, T C; Petrak, S; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Pioppi, M; Piredda, G; Pivk, M; Plaszczynski, S; Playfer, S; Pompili, A; Poropat, P; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prepost, R; Pripstein, M; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rama, M; Rankin, P; Ratcliff, B N; Raven, G; Re, V; Reidy, J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roat, C; Roberts, D A; Robertson, S H; Robutti, E; Roe, N A; Röthel, W; Ronan, Michael T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Rubin, A E; Ryd, A; Saeed, M A; Safai-Tehrani, F; Saleem, M; Salnikov, A A; Salvatore, F; Samuel, A; Sanders, D A; Sandrelli, F; Santroni, A; Saremi, S; Sarti, A; Satpathy, A; Schalk, T; Schindler, R H; Schott, G; Schrenk, S; Schubert, J; Schubert, Klaus R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Sharma, V; Shelkov, V G; Shen, B C; Simani, M C; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Sloane, R J; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Soha, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spradlin, P; Stängle, H; Steinke, M; Stelzer, J; Stoker, D P; Stroili, R; Strom, D; Stugu, B; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; T'Jampens, S; Tan, P; Tantot, L; Taras, P; Taylor, F; Taylor, G P; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thiessen, D; Tiozzo, G; Tisserand, V; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Treadwell, E; Vasileiadis, G; Vasseur, G; Vavra, J; Verderi, M; Verkerke, W; Vitale, L; Voci, C; Voena, C; Vuagnin, G; Wagner, G; Wagner, S R; Wagoner, D E; Waldi, R; Walsh, J; Wang, K; Wang, P; Wappler, F R; Watson, A T; Weaver, M; Weidemann, A W; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Willocq, S; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winter, M A; Wisniewski, W J; Wittgen, M; Won, E; Wong, Q K; Wormser, G; Wright, D H; Wright, D M; Wu, J; Wu, S L; Xie, Y; Yamamoto, R K; Yang, S; Yarritu, A K; Ye, S; Yéche, C; Yi, J; Young, C C; Yu, Z; Yumiceva, F X; Yushkov, A N; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Zhu, Y S; Zito, M; De Sangro, R; Del Re, D; La Vaissière, C de

    2004-01-01

    We present preliminary results on the Dalitz plot analysis of $B^0 \\to K^+ \\pi^- \\pi^0$ decays. The data sample comprises 213 million $\\Upsilon(4S) \\to B {\\bar B}$ decays collected with the BaBar detector at the PEP-II asymmetric-energy $B$ Factory at SLAC. We report measurements of the inclusive branching fraction, quasi-two-body fractions and CP-violating charge asymmetries for intermediate states including $K^*(892)^+ \\pi^-$ and $\\rho(770)^- K^+$. Observations of $B^0$ decays to the $K\\pi$ $S$-wave intermediate states, $K_0^*(1430)^+ \\pi^-$ and $K_0^*(1430)^0 \\pi^0$, are reported. Evidence of the decay $B^0 \\to K^*(892)^0 \\pi^0$ is seen. We set upper limits at 90% confidence level on branching fractions of the nonresonant and other less significant intermediate states.

  20. Dalitz Plot Analysis of Ds to K+K-pi+

    CERN Document Server

    Mitchell, R E

    2009-01-01

    We perform a Dalitz plot analysis of the decay Ds to K+K-pi+ with the CLEO-c data set of 586/pb of e+e- collisions accumulated at sqrt(s) = 4.17 GeV. This corresponds to about 0.57 million D_s+D_s(*)- pairs from which we select 14400 candidates with a background of roughly 15%. In contrast to previous measurements we find good agreement with our data only by including an additional f_0(1370)pi+ contribution. We measure the magnitude, phase, and fit fraction of K*(892) K+, phi(1020)pi+, K0*(1430)K+, f_0(980)pi+, f_0(1710)pi+, and f_0(1370)pi+ contributions and limit the possible contributions of other KK and Kpi resonances that could appear in this decay.

  1. Finding the plot in South African reading education

    Directory of Open Access Journals (Sweden)

    Peter Rule

    2017-01-01

    Full Text Available This article argues that we have lost the plot in South African reading education. To find it, we need to move beyond the predominant mode of reading as oral performance, where the emphasis is on accuracy and pronunciation, to reading as comprehension of meaning in text. While reading research in South Africa has been conducted mainly in school contexts, this case study is of a school and Adult Basic Education and Training Centre in a rural KwaZulu-Natal community near Pietermaritzburg. It found that an oratorical approach to reading dominated in both settings. It suggests that developing the way in which teachers understand the teaching of reading and transforming the teaching practices of those who teach as they were taught in the education system of the apartheid era are key to improving the teaching of reading.

  2. Parallel coordinate plots of maize traits under different magnesium applications

    Institute of Scientific and Technical Information of China (English)

    Jan Bocianowski; Piotr Szulc; Kamila Nowosad

    2015-01-01

    The paral el coordinate plot is proposed as an efifcient tool for visualization of 13 traits of“stay-green”maize (Zea mays L.) cultivar exposed to different methods of magnesium application. The ifeld experiment was conducted in the Department of Agronomy, PoznańUniversity of Life Sciences, on the ifelds of the Department of Teaching and Experimental Station in Swadzim in 2006–2008. Experiment was conducted as a single-factor experiment with seven applications of magnesium in a randomized complete block design with four replicates. The highest mean values of grain yield and 1 000-grain weight were obtained after application of variant T3 of magnesium (10 kg MgO ha–1 soil) in the al three years of study.

  3. Steroid hormone runoff from agricultural test plots applied with municipal biosolids

    Science.gov (United States)

    Yang, Yun-Ya; Gray, James L.; Furlong, Edward T.; Davis, Jessica G.; ReVollo, Rhiannon C.; Borch, Thomas

    2012-01-01

    The potential presence of steroid hormones in runoff from sites where biosolids have been used as agricultural fertilizers is an environmental concern. A study was conducted to assess the potential for runoff of seventeen different hormones and two sterols, including androgens, estrogens, and progestogens from agricultural test plots. The field containing the test plots had been applied with biosolids for the first time immediately prior to this study. Target compounds were isolated by solid-phase extraction (water samples) and pressurized solvent extraction (solid samples), derivatized, and analyzed by gas chromatography–tandem mass spectrometry. Runoff samples collected prior to biosolids application had low concentrations of two hormones (estrone -1 and androstenedione -1) and cholesterol (22.5 ± 3.8 μg L-1). In contrast, significantly higher concentrations of multiple estrogens (-1), androgens (-1), and progesterone (-1) were observed in runoff samples taken 1, 8, and 35 days after biosolids application. A significant positive correlation was observed between antecedent rainfall amount and hormone mass loads (runoff). Hormones in runoff were primarily present in the dissolved phase (hormones from biosolids-amended agricultural fields, directly to surface waters or redistributed to terrestrial sites away from the point of application via runoff. Although concentrations decrease over time, 35 days is insufficient for complete degradation of hormones in soil at this site.

  4. Plant mycorrhizal traits and carbon fates from plot to globe

    Science.gov (United States)

    Soudzilovskaia, N.; Cornelissen, H. H. C.

    2016-12-01

    Evidence is accumulating that plant traits related to mycorrhizal symbiosis, i.e. mycorrhizal type and the degree of plant root colonization by mycorrhizal fungi have important consequences for carbon pools and allocation in plants and soil. How plant and soil carbon pools vary among vegetation dominated by plants of different mycorrhizal types is a new and exciting research challenge. Absence of global databases on abundance of mycorrhizal fungi in soil and plant roots retards research aimed to understand involvement of mycorrhizas into soil carbon transformation processes. Using own data and published studies we have assembled currently world-largest database of plant species-per-site degrees root colonization by two most common types of mycorrhizal fungi, arbuscular mycorrhizal (AM) and ectomycorrhizal (EM). The database features records for plant root colonization degrees by AM and EM (above 8000 records in total). Using this database, we demonstrate that the degree of mycorrhizal fungal colonization has globally consistent patterns across plant species. This suggests that the level of plant species-specific root colonization can be used as a plant trait. I will discuss how combining plot-level field data, literature data and mycorrhizal infection trait data may help us to quantify the carbon consequences of relative dominance by arbuscular versus ectomycorrhizal symbiosis in vegetation from plot to global scale. To exemplify this method, I will present an assessment of the impacts of EM shrub encroachment on carbon stocks in sub-arctic tundra, and show how the plant trait data (root, leaf, stem and mycorrhizal colonization traits) could predict (1) impacts of AM and EM vegetation on soil carbon budget and (2) changes in soil carbon budget due to increase of EM plants in an AM-dominated ecosystem and visa versa. This approach may help to predict how global change-mediated vegetation shifts, via mycorrhizal carbon pools and dynamics, may affect terrestric and

  5. M2-F1 on lakebed with pilots Milt Thompson, Chuck Yeager, Don Mallick, and Bruce Peterson

    Science.gov (United States)

    1963-01-01

    -made by Gus Briegleb and company. Ernie Lowder, a NASA craftsman who had worked on the Howard Hughes 'Spruce Goose,' was assigned to help Briegleb. The prototype of a 21st Century spacecraft required the fabrication of hundreds of small wooden parts meticulously nailed and glued together. It was a product of craftsmanship that was nearly obsolete in the 1940s. Final assembly of the remaining components (including aluminum tail surfaces, push rod controls, and landing gear from a Cessna 150) was done back at the NASA facility. In the meantime, other NASA engineers devised a special M2-F1 flight simulator, and a hot rod shop near Long Beach souped-up a Pontiac convertible to be used as the lifting body ground-tow vehicle. The M2-F1 did not have ailerons. Instead, it had elevons which were attached to each of the two rudders. A large flap on the trailing edge of the body acted as an elevator. This unconventional arrangement prompted the engineers to rethink the flight control system as well. They eventually devised two schemes. One system was fairly traditional. It used rudder pedal inputs to move the rudders for yaw control, and stick inputs to provide differential deflections of the elevons for roll. The other system used stick inputs to control the rudders for yaw, while rudder pedal deflections moved the elevons for roll. Milt Thompson tried both systems in the simulator and surprised the design team when he said he preferred system number two. He reasoned that although sideslip delayed roll (which was a result of dihedral effect), the roll rate was twice as high using the rudders instead of the elevons. He said he would rather have the higher roll rates available to him if needed, while the slip could be overcome with proper piloting technique. This was the system that Thompson practiced on the simulator, and he used it during the initial auto tows. Auto tows were done using a 1000 foot rope fastened to the NASA Pontiac. Rogers Dry Lake provided miles of unobstructed

  6. Long-term Trends of Plot-scale Cs-137 Wash-off on Various Land Uses in the Area Affected by the Accident of Fukushima Dai-ichi Nuclear Power Plant

    Science.gov (United States)

    Wakiyama, Y.; Onda, Y.; Yoshimura, K.; Takahashi, J.; Nakamura, N.; Manome, R.

    2015-12-01

    Understanding plot-scale Cs-137 wash-off is indispensable for predicting Cs-137 fate. However, there are only a few numbers of long-term observations and hence lack of information on temporal trends of Cs-137 wash-off leaves uncertainties on the predictions. This study shows approximately three years' observation results of plot-scale Cs-137 wash-off from various land uses after the accident of Fukushima Dai-ichi Nuclear Power Plant. Erosion plots (22.3 m × 5.0 m) were established in 2011 and 2013 on two uncultivated farmlands (FL-A1, FL-B1), two cultivated farmlands (FL-A2, FL-B2), three grasslands (GL-A, GL-B, GL-C) and one Japanese cedar forest (JCdF) in Kawamata town. Eroded sediments as well as the data of rainfall and vegetation cover were collected almost every two weeks. At the end of observations, we took soil samples from three to nine points on each plot with scraper plates (30 cm ×15 cm) to obtain Cs-137 depth distributions. Collected sediment and soil samples were dried, weighed and measured with HPGe type gamma detectors. We calculated βeff, 'effective' relaxation depth (g/m2), based on Cs-137 depth distributions. Annual soil loss ranged from 0.04 to 75 t/ha/year and the largest was from FL-A2 followed by FL-B2, FL-A1, FL-B1, GL-A, GL-B, JCdF and then GL-C. Sediment amount weighted mean values of Cs-137 concentration normalized by initial deposition density ranged from 0.0062 to 0.084 ((Bq/kg)/(Bq/m2)) and the largest was from JCdF followed by FL-B1, FL-A1, GL-A, FL-A2, FL-B2, GL-B, and then GL-C. Decreasing trends of Cs-137 concentration were found on FL-A1 and FL-B1, whereas no trend was found on other plots due to constant values on FL-A2 and FL-B2 and due to variable values on GL-C, GL-B, GL-C and JCdF. Depth distributions of Cs-137 on FL-A1 and FL-B1 showed exponential distributions with low inventories on their upslope points and deeper penetrations with high inventories on their downslope points. Mean values of βeff ranged from 2.1 to 24

  7. Carbon dioxide balance of subarctic tundra from plot to regional scales

    Directory of Open Access Journals (Sweden)

    M. E. Marushchak

    2013-01-01

    Full Text Available We report here the carbon dioxide (CO2 budget of a 98.6 km2 subarctic tundra area in northeast European Russia based on measurements at two different scales and two independent upscaling approaches. Plot-scale measurements (chambers on terrestrial surfaces, gas gradient method and bubble collectors on lakes were carried out from July 2007 to October 2008. The landscape-scale eddy covariance (EC measurements covered the snow-free period of 2008. The annual net ecosystem exchange (NEE of different land cover types ranged from −251 to 84 g C m−2. Leaf area index (LAI was an excellent predictor of the spatial variability in gross photosynthesis (GP, NEE and ecosystem respiration (ER. The plot-scale CO2 fluxes were first scaled up to the EC source area and then to the whole study area using two data sets: a land cover classification and a LAI map, both based on field data and a 2.4 m pixel-sized QuickBird satellite image. The good agreement of the CO2 balances for the EC footprint based on the different measuring techniques (−105 to −81 g C m−2 vs. −79 g C m−2; growing season 2008 justified the integration of the plot-scale measurements over the larger area. The regional CO2 balance based on area-integrated plot-scale measurements was −41 or −79 g C m−2 yr−1 according to the two upscaling methods, the land cover classification and the LAI map, respectively. Due to the heterogeneity of tundra, the effect of climate change on CO2 uptake will vary strongly according to the land cover type and, moreover, likely changes in their relative coverage in the future will have great impact on the regional CO2 balance.

  8. Field Plot and Accuracy Assessment Points for Bent's Old Fort National Historic Site Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — Accuracy Assessment, Observation and Plot Points. Plots within the park were identified and sampled in the summer of 2005. In the summer of 2006, randomly selected...

  9. Field Plot and Accuracy Assessment Points for Padre Island National Seashore Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — Accuracy Assessment, Observation and Plot Points. Currently there are NO DATA in this feature class. As of December 2009, a plots database has not been developed and...

  10. Field Plot and Observation Points for Natural Bridges National Monument Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — This point file displays the 97 field plot and observation points visited in 2003 & 2004 as part of the vegetation mapping project. Sample plots were located...

  11. Field Plot Points Modified for Fort Necessity National Battlefield Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — Locations of vegetation classification sampling plots at Fort Necessity National Battlefield. In this data set, the X, Y coordinates for three plots have been...

  12. Field Plot and Observation Points for Dinosaur National Monument Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — This point file displays the 727 vegetation plots and 217 observation points visited in 2002, 2003 and 2004 as part of the vegetation mapping project. Plots and...

  13. M2-KK6 System in ABJM Theory : Fuzzy $S^3$ and Wrapped KK6

    CERN Document Server

    Huang, Wung-Hong

    2011-01-01

    We study the properties of M2-KK6 solution in ABJM membrane theory. First, we find a new kind of BPS solution which has six coordinates, contrasts to our previous solutions which have four coordinates. Next, we argue that, after wrapping 2 sphere the new solution may correspond to the previous solution of four coordinates. We analyze the properties therein and conclude that M2-branes described in ABJM theory could expand into fuzzy three sphere plus a wrapped 2 sphere near the KK6 core. Especially, we show in detail how the fuzzy 3-sphere could arise in these solutions and discuss the property of wrapped KK6 and its relation to M5-brane. We also analyze the fluctuation of the M2-KK6 solution and see that it is U(1) field theory.

  14. Holographic cosmology from a system of M2–M5 branes

    Energy Technology Data Exchange (ETDEWEB)

    Sepehri, Alireza, E-mail: alireza.sepehri@uk.ac.ir [Faculty of Physics, Shahid Bahonar University, P.O. Box 76175, Kerman (Iran, Islamic Republic of); Research Institute for Astronomy and Astrophysics of Maragha (RIAAM), Maragha (Iran, Islamic Republic of); Faizal, Mir, E-mail: f2mir@uwaterloo.ca [Department of Physics and Astronomy, University of Waterloo, Waterloo, ON, N2L 3G1 (Canada); Setare, Mohammad Reza, E-mail: rezakord@ipm.ir [Department of Science, Campus of Bijar, University of Kurdistan, Bijar (Iran, Islamic Republic of); Ali, Ahmed Farag, E-mail: afali@fsu.edu [Department of Physics, Florida State University, Tallahassee, FL 32306 (United States); Department of Physics, Faculty of Science, Benha University, Benha 13518 (Egypt)

    2016-05-15

    In this paper, we analyze the holographic cosmology using a M2–M5 brane configuration. In this configuration, a M2-brane will be placed in between a M5-brane and an anti-M5-brane. The M2-brane will act as a channel for energy to flow from an anti-M5-brane to a M5-brane, and this will increase the degrees of freedom on the M5-brane causing inflation. The inflation will end when the M5-brane and anti-M5-brane get separated. However, at a later stage the distance between the M5-brane and the anti-M5-bran can reduce and this will cause the formation of tachyonic states. These tachyonic states will again open a bridge between the M5-branes and the anti-M5-branes, which will cause further acceleration of the universe.

  15. A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor.

    Science.gov (United States)

    Barchad-Avitzur, Ofra; Priest, Michael F; Dekel, Noa; Bezanilla, Francisco; Parnas, Hanna; Ben-Chaim, Yair

    2016-10-04

    G protein-coupled receptors (GPCRs) mediate many signal transduction processes in the body. The discovery that these receptors are voltage-sensitive has changed our understanding of their behavior. The M2 muscarinic acetylcholine receptor (M2R) was found to exhibit depolarization-induced charge movement-associated currents, implying that this prototypical GPCR possesses a voltage sensor. However, the typical domain that serves as a voltage sensor in voltage-gated channels is not present in GPCRs, making the search for the voltage sensor in the latter challenging. Here, we examine the M2R and describe a voltage sensor that is comprised of tyrosine residues. This voltage sensor is crucial for the voltage dependence of agonist binding to the receptor. The tyrosine-based voltage sensor discovered here constitutes a noncanonical by which membrane proteins may sense voltage.

  16. Aggregation and Trunking of M2M Traffic via D2D Connections

    DEFF Research Database (Denmark)

    Rigazzi, Giovanni; Kiilerich Pratas, Nuno; Popovski, Petar

    2015-01-01

    , there is a need for new techniques to coordinate the access and allocate the resources. Although the majority of the proposed solutions are focused on the adaptation of the traditional cellular networks to the M2M traffic patterns, novel approaches based on the direct communication among nearby devices may......Machine-to-Machine (M2M) communications is one of the key enablers of the Internet of Things (IoT). Billions of devices are expected to be deployed in the near future for novel M2M applications demanding ubiquitous access and global connectivity. In order to cope with the massive number of machines...... generated packets is performed by a user device, which aggregates the machine-type data, supplements it with its own data and transmits all of them to the Base Station. We observe a fundamental trade-off between latency and the transmit power needed to deliver the aggregate traffic, in a sense that lower...

  17. Holographic cosmology from a system of M2-M5 branes

    Science.gov (United States)

    Sepehri, Alireza; Faizal, Mir; Setare, Mohammad Reza; Ali, Ahmed Farag

    2016-05-01

    In this paper, we analyze the holographic cosmology using a M2-M5 brane configuration. In this configuration, a M2-brane will be placed in between a M5-brane and an anti-M5-brane. The M2-brane will act as a channel for energy to flow from an anti-M5-brane to a M5-brane, and this will increase the degrees of freedom on the M5-brane causing inflation. The inflation will end when the M5-brane and anti-M5-brane get separated. However, at a later stage the distance between the M5-brane and the anti-M5-bran can reduce and this will cause the formation of tachyonic states. These tachyonic states will again open a bridge between the M5-branes and the anti-M5-branes, which will cause further acceleration of the universe.

  18. Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake.

    Science.gov (United States)

    Grinter, Rhys; Josts, Inokentijs; Zeth, Kornelius; Roszak, Aleksander W; McCaughey, Laura C; Cogdell, Richard J; Milner, Joel J; Kelly, Sharon M; Byron, Olwyn; Walker, Daniel

    2014-07-01

    The colicin-like bacteriocins are potent protein antibiotics that have evolved to efficiently cross the outer membrane of Gram-negative bacteria by parasitizing nutrient uptake systems. We have structurally characterized the colicin M-like bacteriocin, pectocin M2, which is active against strains of Pectobacterium spp. This unusual bacteriocin lacks the intrinsically unstructured translocation domain that usually mediates translocation of these bacteriocins across the outer membrane, containing only a single globular ferredoxin domain connected to its cytotoxic domain by a flexible α-helix, which allows it to adopt two distinct conformations in solution. The ferredoxin domain of pectocin M2 is homologous to plant ferredoxins and allows pectocin M2 to parasitize a system utilized by Pectobacterium to obtain iron during infection of plants. Furthermore, we identify a novel ferredoxin-containing bacteriocin pectocin P, which possesses a cytotoxic domain homologous to lysozyme, illustrating that the ferredoxin domain acts as a generic delivery module for cytotoxic domains in Pectobacterium.

  19. Water-mediated conformational transitions in nicotinic receptor M2 helix bundles: a molecular dynamics study.

    Science.gov (United States)

    Sankararamakrishnan, R; Sansom, M S

    1995-12-27

    The ion channel of the nicotinic acetylcholine receptor is a water-filled pore formed by five M2 helix segments, one from each subunit. Molecular dynamics simulations on bundles of five M2 alpha 7 helices surrounding a central column of water and with caps of water molecules at either end of the pore have been used to explore the effects of intrapore water on helix packing. Interactions of water molecules with the N-terminal polar sidechains lead to a conformational transition from right- to left-handed supercoils during these stimulations. These studies reveal that the pore formed by the bundle of M2 helices is flexible. A structural role is proposed for water molecules in determining the geometry of bundles of isolated pore-forming helices.

  20. Quantification and localization of M2 macrophages in human kidneys with acute tubular injury

    Directory of Open Access Journals (Sweden)

    Palmer MB

    2014-11-01

    Full Text Available Matthew B Palmer,1 Alfred A Vichot,2 Lloyd G Cantley,2 Gilbert W Moeckel1 1Department of Pathology, Yale University School of Medicine, New Haven, CT, USA; 2Department of Medicine, Yale University School of Medicine, New Haven, CT, USA Abstract: This study addresses for the first time the question whether there is significant macrophage population in human kidney sections from patients with acute tubular injury (ATI. We examined therefore the interstitial macrophage population in human kidney tissue with biopsy-proven diagnosis of ATI, minimal change disease (MCD, and MCD with ATI. Kidney biopsies from patients with the above diagnoses were stained with antibodies directed against CD68 (general macrophage marker, CD163 (M2 marker, and HLA-DR (M1 marker and their respective electron microscopy samples were evaluated for the presence of interstitial macrophages. Our study shows that patients with ATI have significantly increased numbers of interstitial CD68+ macrophages, with an increase in both HLA-DR+ M1 macrophages and CD163+ M2 macrophages as compared to patients with MCD alone. Approximately 75% of macrophages were M2 (CD163+ whereas only 25% were M1 (HLA-DR+. M2 macrophages, which are believed to be critical for wound healing, were found to localize close to the tubular basement membrane of injured proximal tubule cells. Ultra structural examination showed close adherence of macrophages to the basement membrane of injured tubular epithelial cells. We conclude that macrophages accumulate around injured tubules following ATI and exhibit predominantly an M2 phenotype. We further speculate that macrophage-mediated repair may involve physical contact between the M2 macrophage and the injured tubular epithelial cell. Keywords: macrophages, acute kidney injury, CD163, HLA-DR, CD68, electron microscopy

  1. Interaction of Tacrine at M1 and M2 Cholinoceptors in Guinea Pig Brain

    Science.gov (United States)

    1993-01-01

    using the selective M, and M2 antagonists [3H]- pirenzepine ([3H]PZ) and [3H]AF-DX 384. The dissocia- tion constants were 0.36 nmol/I for the M...nmol/I) at 25*C with 200 ml homogenate made nist [3H]- pirenzepine ([3HJPZ) [4, 5] and the up to 2 ml with buffer. The incubation period was 2 h...tion constant; nH = Hill coefficient; n = number of experiments. pirenzepine indicate that its affinity for the T"M. 2. Dissociation constants for [3H

  2. Spontaneous thermal motion of the GABA(A) receptor M2 channel-lining segments.

    Science.gov (United States)

    Bera, Amal K; Akabas, Myles H

    2005-10-21

    The gamma-aminobutyric acid type A (GABA(A)) receptor channel opening involves translational and rotational motions of the five channel-lining, M2 transmembrane segments. The M2 segment's extracellular half is loosely packed and undergoes significant thermal motion. To characterize the extent of the M2 segment's motion, we used disulfide trapping experiments between pairs of engineered cysteines. In alpha1beta1 gamma2S receptors the single gamma subunit is flanked by an alpha and beta subunit. The gamma2 M2-14' position is located in the alpha-gamma subunit interface. Gamma2 13' faces the channel lumen. We expressed either the gamma2 14' or the gamma2 13' cysteine substitution mutants with alpha1 cysteine substitution mutants between 12' and 16' and wild-type beta1. Disulfide bonds formed spontaneously between gamma2 14'C and both alpha1 15'C and alpha1 16'C and also between gamma2 13'C and alpha1 13'C. Oxidation by copper phenanthroline induced disulfide bond formation between gamma2 14'C and alpha1 13'C. Disulfide bond formation rates with gamma2 14'C were similar in the presence and absence of GABA, although the rate with alpha1 13'C was slower than with the other two positions. In a homology model based on the acetylcholine receptor structure, alphaM2 would need to rotate in opposite directions by approximately 80 degrees to bring alpha1 13' and alpha1 15' into close proximity with gamma2 14'. Alternatively, translational motion of alphaM2 would reduce the extent of rotational motion necessary to bring these two alpha subunit residues into close proximity with the gamma2 14' position. These experiments demonstrate that in the closed state the M2 segments undergo continuous spontaneous motion in the region near the extracellular end of the channel gate. Opening the gate may involve similar but concerted motions of the M2 segments.

  3. Spontaneous mobility of GABAA receptor M2 extracellular half relative to noncompetitive antagonist action.

    Science.gov (United States)

    Chen, Ligong; Durkin, Kathleen A; Casida, John E

    2006-12-15

    The gamma-aminobutyric acid type A receptor beta(3) homopentamer is spontaneously open and highly sensitive to many noncompetitive antagonists(NCAs) and Zn(2+). Our earlier study of the M2 cytoplasmic half (-1' to 10') established a model in which NCAs bind at pore-lining residues Ala(2)', Thr(6)', and Leu(9)'. To further define transmembrane 2 (M2) structure relative to NCA action, we extended the Cys scanning to the extra cellular half of the beta(3) homopentamer (11' to 20'). Spontaneous disulfides formed with T13'C, L18'C, and E20'C from M2/M2 cross-linking and with I14'C (weak), H17'C, and R19'Con bridging M2/M3 intersubunits, based on single (M2 Cys only) and dual (M2 Cys plus M3 C289S) mutations. Induced disulfides also formed with T16'C, but there were few or none with M11'C, T12'C, and N15'C. These findings show conformational flexibility/mobility in the M2 extracellular half 17' to 20' region interpreted as a deformed beta-like conformation in the open channel. The NCA radioligands used were [(3)H]1-(4-ethynylphenyl)-4-n-propyl-2,6,7-trioxabicyclo[2.2.2]octane ([(3)H]EBOB) and [(3)H]3,3-bis-trifluoromethylbicyclo[2.2.1]heptane-2,2-dicarbonitrile with essentially the same results. NCA binding was disrupted by individual Cys substitutions at 13',14',16',17', and 19'. The inactivity of T13'C/T13'S may have been due to disturbance of the channel gate; I14'S and T16'S showed much better binding activity than their Cys counterparts, and the low activities of H17'C and R19'C were reversed by dithiothreitol. Zn(2+) potency for inhibition of [(3)H]EBOB binding was lowered 346-fold by the mutation H17'A. We propose that NCAs enter their binding site both directly, through the channel pore, and indirectly, through the water cavity of adjacent subunits.

  4. 广雅SUNDAY三期7500元/m2起发售

    Institute of Scientific and Technical Information of China (English)

    张雷

    2008-01-01

    本报讯 6月22日,SUNDAY三期发售,此前已有近300名买家进行购买登记,而发展商把300多套货量一并推出,以最低价格7000元/m2,最高也不超过1万元/m2的诱人价格,且发售当天买家可享受95折优惠。

  5. Contrasting effects of microbiotic crusts on runoff in desert surfaces

    Science.gov (United States)

    Kidron, Giora J.; Monger, H. Curtis; Vonshak, Ahuva; Conrod, William

    2012-02-01

    Microbiotic crusts (MCs) play an important role in surface hydrology by altering runoff yield. In order to study the crust's role on water redistribution, rainfall and runoff were measured during 1998-2000 at three sites within the northern Chihuahuan Desert, New Mexico, USA: the Sevilleta National Wildlife Refuge (SEV), the White Sands National Monument (WS), and the Jornada Experimental Range (JER). Whereas quartz and gypsum sand characterize the SEV and WS sites, respectively, both of which have high infiltration rates, silty alluvial deposits characterize the JER site. Runoff was measured in four pairs of 1.8-6.4 m 2 plots having MCs, one of which was scalped in each pair. No runoff was generated at WS, whether on the crusted or the scalped plots. Runoff was however generated at SEV and JER, being higher on the crusted plots at SEV and lower on the JER plots. The results were explained by the combined effect of (a) parent material and (b) the crust properties, such as species composition, microrelief (surface roughness) and exopolysaccharide (EPS) content (reflected in the ratio of carbohydrates to chlorophyll). Whereas the effective rainfall, the fines and the EPS content were found to explain runoff initiation, the effective rainfall and the crust microrelief were found to explain the amount of runoff at SEV and JER where runoff generation took place. The findings attest to the fundamental role of the parent material and the crust's species composition and properties on runoff and hence to the complex interactions and the variable effects that MCs have on dryland hydrology.

  6. Sensitivity-Based Modeling of Evaluating Surface Runoff and Sediment Load using Digital and Analog Mechanisms

    Directory of Open Access Journals (Sweden)

    Olotu Yahaya

    2014-07-01

    Full Text Available Analyses of runoff- sediment measurement and evaluation using automated and convectional runoff-meters was carried out at Meteorological and Hydrological Station of Auchi Polytechnic, Auchi using two runoff plots (ABCDa and EFGHm of area 2m 2 each, depth 0.26 m and driven into the soil to the depth of 0.13m. Runoff depths and intensities were measured from each of the positioned runoff plot. Automated runoff-meter has a measuring accuracy of ±0.001l/±0.025 mm and rainfall depth-intensity was measured using tipping-bucket rainguage during the period of 14-month of experimentation. Minimum and maximum rainfall depths of 1.2 and 190.3 mm correspond to measured runoff depths (MRo of 0.0 mm for both measurement approaches and 60.4 mm and 48.9 mm respectively. Automated runoffmeter provides precise, accurate and instantaneous result over the convectional measurement of surface runoff. Runoff measuring accuracy for automated runoff-meter from the plot (ABCDa produces R 2 = 0.99; while R 2 = 0.96 for manual evaluation in plot (EFGHm. WEPP and SWAT models were used to simulate the obtained hydrological variables from the applied measurement mechanisms. The outputs of sensitivity simulation analysis indicate that data from automated measuring systems gives a better modelling index and such could be used for running robust runoff-sediment predictive modelling technique under different reservoir sedimentation and water management scenarios.

  7. Maintaining a permanent plot data base for growth and yield research: Solutions to some recurring problems

    Science.gov (United States)

    John C. Byrne

    1993-01-01

    Methods for solving some recurring problems of maintaining a permanent plot data base for growth and yield reseuch are described. These methods include documenting data from diverse sampling designs, changing sampling designs, changing field procedures, and coordinating activities in the plots with the land management agency. Managing a permanent plot data base (...

  8. The influence of fipronil on Reticulitermes flavipes (Isoptera: Rhinotermitidae) feeding beyond treated plots

    Science.gov (United States)

    Thomas Shelton

    2013-01-01

    A small-plot field trial was conducted to examine the area of influence of fipronil at incremental distances away from treated plots on the Harrison Experimental Forest near Saucier, MS. Small treated (water and fipronil) plots were surrounded by untreated wooden boards in an eight-point radial pattern, and examined for evidence of termite feeding every 60 d for 1 yr...

  9. Classification of calorimetric titration plots for alkyltrimethylammonium and alkylpyridinium cationic surfactants in aqueous solutions

    NARCIS (Netherlands)

    Bijma, K; Engberts, J.B.F.N.; Blandamer, M.J; Cullis, P.M.; Last, P.M.; Irlam, K.D.; Soldi, L.G.

    1997-01-01

    Calorimetric titration plots for deaggregation of micelles formed by alkylpyridinium and alkyltrimethylammonium surfactants are classified into three types, A, B and C, depending on the shape of the plot of the enthalpy of dilution as a function of surfactant concentration. For Type A plots the reco

  10. Fitting Data to Model: Structural Equation Modeling Diagnosis Using Two Scatter Plots

    Science.gov (United States)

    Yuan, Ke-Hai; Hayashi, Kentaro

    2010-01-01

    This article introduces two simple scatter plots for model diagnosis in structural equation modeling. One plot contrasts a residual-based M-distance of the structural model with the M-distance for the factor score. It contains information on outliers, good leverage observations, bad leverage observations, and normal cases. The other plot contrasts…

  11. Classification of calorimetric titration plots for alkyltrimethylammonium and alkylpyridinium cationic surfactants in aqueous solutions

    NARCIS (Netherlands)

    Bijma, K; Engberts, J.B.F.N.; Blandamer, M.J; Cullis, P.M.; Last, P.M.; Irlam, K.D.; Soldi, L.G.

    1997-01-01

    Calorimetric titration plots for deaggregation of micelles formed by alkylpyridinium and alkyltrimethylammonium surfactants are classified into three types, A, B and C, depending on the shape of the plot of the enthalpy of dilution as a function of surfactant concentration. For Type A plots the

  12. M2M monitoring terminal based on Cortex-M3%基于Cortex-M3的M2M监控终端

    Institute of Scientific and Technical Information of China (English)

    张鑫; 丁志刚; 郑树泉

    2011-01-01

    在对物联网在工业监控领域的应用研究后,针对目前工业监控终端体积大、容量小、功能简单等问题,设计并实现了一种微型化、大容量、强实时、多参数的M2M监控终端.该终端设计了基本的监控模块,且针对不同的应用环境预设了可配和选择模块,使适用范围更广.实现了网络动态配置接口,提高了终端的通用性.并借鉴传统数据采集模式,设计一种数据采集和数据传输优化方案,并对优化算法进行探讨,经应用结果分析,对系统开销、数据传输等指标有显著的改进.%After research of the application of Internet of Things (IOT) in industrial control field, according to the monitoring terminal problems that large volume, low-capacity and simple function, a miniaturized, high-capacity, strong realtime, multi-parameter M2M monitoring terminal was designed and implemented. The terminal designed a basic control module, and the default for different applications and options that could be equipped with modules and applied more broadly. It achieved dynamic configuration of network interfaces and improved the versatility of the terminal. Learning from the traditional mode of data acquisition, the paper devised a prioritization scheme of data acquisition and data transmission, and discussed optimization algorithm. The results of applications show that it is a noticeable improvement in the index of system overhead and data transmission.

  13. M2-F1 in flight over lakebed on tow line

    Science.gov (United States)

    1963-01-01

    Following the first M2-F1 airtow flight on 16 August 1963, the Flight Research Center used the vehicle for both research flights and to check out new lifting-body pilots. These included Bruce Peterson, Don Mallick, Fred Haise, and Bill Dana from NASA. Air Force pilots who flew the M2-F1 included Chuck Yeager, Jerry Gentry, Joe Engle, Jim Wood, and Don Sorlie, although Wood, Haise, and Engle only flew on car tows. In the three years between the first and last flights of the M2-F1, it made about 400 car tows and 77 air tows. The wingless, lifting body aircraft design was initially concieved as a means of landing an aircraft horizontally after atmospheric reentry. The absence of wings would make the extreme heat of re-entry less damaging to the vehicle. In 1962, Dryden management approved a program to build a lightweight, unpowered lifting body as a prototype to flight test the wingless concept. It would look like a 'flying bathtub,' and was designated the M2-F1, the 'M' referring to 'manned' and 'F' referring to 'flight' version. It featured a plywood shell placed over a tubular steel frame crafted at Dryden. Construction was completed in 1963. The first flight tests of the M2-F1 were over Rogers Dry Lake at the end of a tow rope attached to a hopped-up Pontiac convertible driven at speeds up to about 120 mph. This vehicle needed to be able to tow the M2-F1 on the Rogers Dry Lakebed adjacent to NASA's Flight Research Center (FRC) at a minimum speed of 100 miles per hour. To do that, it had to handle the 400-pound pull of the M2-F1. Walter 'Whitey' Whiteside, who was a retired Air Force maintenance officer working in the FRC's Flight Operations Division, was a dirt-bike rider and hot-rodder. Together with Boyden 'Bud' Bearce in the Procurement and Supply Branch of the FRC, Whitey acquired a Pontiac Catalina convertible with the largest engine available. He took the car to Bill Straup's renowned hot-rod shop near Long Beach for modification. With a special gearbox and

  14. Recent Development of QCD Factorization for B-> M1 M2

    CERN Document Server

    Yang, Deshan

    2010-01-01

    After briefly introducing the framework of QCD factorization for B-> M1 M2 in the language of the Soft-Collinear Effective Theory, we firstly address the recent efforts on higher-order radiative corrections in QCD factorization. Then we discuss some phenomenologies in B-> V V within the framework of QCD factorization.

  15. Kinetics of proton transport into influenza virions by the viral M2 channel.

    Directory of Open Access Journals (Sweden)

    Tijana Ivanovic

    Full Text Available M2 protein of influenza A viruses is a tetrameric transmembrane proton channel, which has essential functions both early and late in the virus infectious cycle. Previous studies of proton transport by M2 have been limited to measurements outside the context of the virus particle. We have developed an in vitro fluorescence-based assay to monitor internal acidification of individual virions triggered to undergo membrane fusion. We show that rimantadine, an inhibitor of M2 proton conductance, blocks the acidification-dependent dissipation of fluorescence from a pH-sensitive virus-content probe. Fusion-pore formation usually follows internal acidification but does not require it. The rate of internal virion acidification increases with external proton concentration and saturates with a pK(m of ∼4.7. The rate of proton transport through a single, fully protonated M2 channel is approximately 100 to 400 protons per second. The saturating proton-concentration dependence and the low rate of internal virion acidification derived from authentic virions support a transporter model for the mechanism of proton transfer.

  16. Tramadol differentially regulates M1 and M2 macrophages from human umbilical cord blood.

    Science.gov (United States)

    Zhang, Jun; Chen, Liang; Sun, Yunyun; Li, Yuanhai

    2017-03-17

    Tramadol is an analgesic drug and relieves pain through activating μ-opioid receptors and inhibiting serotonin and noradrenaline reuptake. Emerging evidence shows that it also stimulates immune cells, including NK cells, splenocytes, and lymphocytes, and elevates IL-2 production. However, it remains unknown whether and how tramadol directly affects macrophages. To answer these questions, we collected human umbilical cord blood, isolated macrophages, and examined their responses to tramadol. Although tramadol did not alter resting macrophages and the antigen-presenting function in lipopolysaccharide-activated macrophages, it regulated M1 and M2 macrophages, which are, respectively, transformed by IFN-γ and IL-4. Interestingly, tramadol inhibits production and secretion of cytokines in M1 macrophages, but facilitates the production of inflammation-responding molecules, synthesized in M2 macrophages. We also found that STAT6 cascade pathway in M2 macrophages was significantly enhanced by tramadol. Therefore, this study reveals that tramadol regulates inflammation by inhibiting M1 macrophages (killing process), but promoting the function of M2 macrophages (healing process).

  17. Embryonic stem cell-derived M2-like macrophages delay cutaneous wound healing.

    Science.gov (United States)

    Dreymueller, Daniela; Denecke, Bernd; Ludwig, Andreas; Jahnen-Dechent, Willi

    2013-01-01

    In adults, repair of deeply injured skin wounds results in the formation of scar tissue, whereas in embryos wounds heal almost scar-free. Macrophages are important mediators of wound healing and secrete cytokines and tissue remodeling enzymes. In contrast to host defense mediated by inflammatory M1 macrophages, wound healing and tissue repair involve regulatory M2/M2-like macrophages. Embryonic/fetal macrophages are M2-like, and this may promote scar-free wound healing. In the present study, we asked whether atopical application of ex vivo generated, embryonic stem cell-derived macrophages (ESDM) improve wound healing in mice. ESDM were tested side by side with bone marrow-derived macrophages (BMDM). Compared to BMDM, ESDM resembled a less inflammatory and more M2-like macrophage subtype as indicated by their reduced responsiveness to lipopolysaccharide, reduced expression of Toll-like receptors, and reduced bacterial phagocytosis. Despite this anti-inflammatory phenotype in cell culture, ESDM prolonged the healing of deep skin wounds even more than BMDM. Healed wounds had more scar formation compared to wounds receiving BMDM or cell-free treatment. Our data indicate that atopical application of ex vivo generated macrophages is not a suitable cell therapy of dermal wounds.

  18. NO EVIDENCE FOR A ROLE OF MUSCARINIC M(2) RECEPTORS IN FUNCTIONAL ANTAGONISM IN BOVINE TRACHEA

    NARCIS (Netherlands)

    ROFFEL, AF; MEURS, H; ELZINGA, CRS; ZAAGSMA, J

    1 The functional antagonism between methacholine- or histamine-induced contraction and beta-adrenoceptor-mediated relaxation was evaluated in bovine tracheal smooth muscle in vitro. In addition, the putative contribution of muscarinic M(2) receptors mediating inhibition of beta-adrenoceptor-induced

  19. Solidification microstructure of M2 high speed steel by different casting technologies

    Directory of Open Access Journals (Sweden)

    Zhou Xuefeng

    2011-08-01

    Full Text Available The present work investigated the solidification microstructure of AISI M2 high speed steel manufactured by different casting technologies, namely iron mould casting and continuous casting. The results revealed that the as-cast structure of the steel was composed of the iron matrix and the M2C eutectic carbide networks, which were greatly refined in the ingot made by continuous casting process, compared with that by the iron mould casting process. M2C eutectic carbides presented variation in their morphologies and growth characteristics in the ingots by both casting methods. In the ingot by iron mould casting, they have a plate-like morphology and grow anisotropically. However, in the ingot made by continuous casting, the carbides evolved into the fiber-like shape that exhibited little characteristics of anisotropic growth. It was noticed that the fiber-like M2C was much easier to decompose and spheroidize after heated, as a result, the carbides refined remarkably, compared with the case of plate-like carbides in the iron mould casting ingot.

  20. Modifications to 25m2 target-aligned research Heliostat mirror panels

    CSIR Research Space (South Africa)

    Roos, TH

    2009-09-01

    Full Text Available Several heliostat mirror panels of the CSIR 25m2 target-aligned heliostat suffered corrosion-related failure, prompting a panel redesign. Two test samples of the new design were subjected to mechanical and thermal cycling tests in an attempt...