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Sample records for lymphoproliferative syndrome alps

  1. Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations

    NARCIS (Netherlands)

    Poppema, Sibrand; Maggio, Ewerton; van den Berg, Anke

    Autoimmune Lymphoproliferative Syndrome (ALPS) is generally the result of a mutation in genes associated with apoptosis, like Fas, Fas ligand, Casp 8 and Casp 10. As a result, the normal homeostasis of T- and B-lymphocytes is disturbed and a proliferation of polyclonal T lymphocytes occurs. This

  2. Autoimmune Lymphoproliferative Syndrome (ALPS)

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  3. Mapping the x-linked lymphoproliferative syndrome

    International Nuclear Information System (INIS)

    Skare, J.C.; Milunsky, A.; Byron, K.S.; Sullivan, J.L.

    1987-01-01

    The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length polymorphism detected with the DXS42 probe (from Xq24-q27). The most likely recombination frequency between the loci is 4%, and the associated logarithm of the odds is 5.26. Haplotype analysis using flanking restriction fragment length polymorphism markers indicates that the locus for X-linked lymphoproliferative syndrome is distal to probe DXS42 but proximal to probe DXS99 (from Xq26-q27). It is now possible to predict which members of a family with X-linked lymphoproliferative syndrome are carrier females and to diagnose the syndrome prenatally

  4. Mapping the x-linked lymphoproliferative syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Skare, J.C.; Milunsky, A.; Byron, K.S.; Sullivan, J.L.

    1987-04-01

    The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length polymorphism detected with the DXS42 probe (from Xq24-q27). The most likely recombination frequency between the loci is 4%, and the associated logarithm of the odds is 5.26. Haplotype analysis using flanking restriction fragment length polymorphism markers indicates that the locus for X-linked lymphoproliferative syndrome is distal to probe DXS42 but proximal to probe DXS99 (from Xq26-q27). It is now possible to predict which members of a family with X-linked lymphoproliferative syndrome are carrier females and to diagnose the syndrome prenatally.

  5. Possible Association of Multicentric Castleman's Disease with Autoimmune Lymphoproliferative Syndrome

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    Hiroyuki Minemura

    2018-04-01

    Full Text Available Multicentric Castleman's disease (MCD is lymphoproliferative disorder characterized by systemic inflammatory symptoms such as fever and weight loss. Human herpes virus-8 (HHV-8 is thought to be a causable pathogen in all HIV-positive and some HIV-negative MCD patients. Furthermore, the term idiopathic MCD (iMCD was recently proposed to represent a group of HIV-negative and HHV-8-negative patients with unknown etiologies. Although the international diagnostic criteria for iMCD require exclusion of infection-related disorders, autoimmune/autoinflammatory diseases and malignant/lymphoproliferative disorders to make an iMCD diagnosis, the relationships and differences between these disorders and MCD have not yet been clarified. We recently reported the first case of MCD with autoimmune lymphoproliferative syndrome (ALPS. Although ALPS was included in the iMCD exclusion criteria as an autoimmune/autoinflammatory disease according to the international diagnostic criteria, there is a lack of evidence on the association between MCD and ALPS. In this study, we review the recent understanding of MCD and discuss the possible association between MCD with ALPS.

  6. IgG4-related disease in autoimmune lymphoproliferative syndrome.

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    van de Ven, Annick A J M; Seidl, Maximilian; Drendel, Vanessa; Schmitt-Graeff, Annette; Voll, Reinhard E; Rensing-Ehl, Anne; Speckmann, Carsten; Ehl, Stephan; Warnatz, Klaus; Kollert, Florian

    2017-07-01

    A patient with autoimmune lymphoproliferative disorder (ALPS) developed IgG4-related disease. In retrospect, he had high levels of serum IgG4 for several years prior to presenting with IgG4-related pancreatitis. These high IgG4 levels were masked by hypergammaglobulinemia, a common feature of ALPS. We next screened 18 ALPS patients; four of them displayed increased levels of IgG4. Hence, IgG4-related disease should be considered in ALPS patients, especially in those manifesting lymphocytic organ infiltration or excessive hypergammaglobulinaemia. Screening of IgG4-related disease patients for ALPS-associated mutations would provide further information on whether this disease could be a late-onset atypical presentation of ALPS. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome.

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    Dowdell, Kennichi C; Niemela, Julie E; Price, Susan; Davis, Joie; Hornung, Ronald L; Oliveira, João Bosco; Puck, Jennifer M; Jaffe, Elaine S; Pittaluga, Stefania; Cohen, Jeffrey I; Fleisher, Thomas A; Rao, V Koneti

    2010-06-24

    Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS gene (type Ia), whereas some cases have been noted to have a somatic mutation of FAS primarily in their DNT cells. We sought to determine the proportion of patients with somatic FAS mutations among a group of our ALPS patients with no detectable germline mutation and to further characterize them. We found more than one-third (12 of 31) of the patients tested had somatic FAS mutations, primarily involving the intracellular domain of FAS resulting in loss of normal FAS signaling. Similar to ALPS type Ia patients, the somatic ALPS patients had increased DNT cell numbers and elevated levels of serum vitamin B(12), interleukin-10, and sFAS-L. These data support testing for somatic FAS mutations in DNT cells from ALPS patients with no detectable germline mutation and a similar clinical and laboratory phenotype to that of ALPS type Ia. These findings also highlight the potential role for somatic mutations in the pathogenesis of nonmalignant and/or autoimmune hematologic conditions in adults and children.

  8. Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome

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    Teachey, David T.; Greiner, Robert; Seif, Alix; Attiyeh, Edward; Bleesing, Jack; Choi, John; Manno, Catherine; Rappaport, Eric; Schwabe, Dirk; Sheen, Cecilia; Sullivan, Kathleen E.; Zhuang, Hongming; Wechsler, Daniel S.; Grupp, Stephan A.

    2010-01-01

    Summary We hypothesized that sirolimus, an mTOR inhibitor, may be effective in patients with autoimmune lymphoproliferative syndrome (ALPS) and treated patients who were intolerant to or failed other therapies. Four patients were treated for autoimmune cytopenias; all had a rapid complete or near complete response. Two patients were treated for autoimmune arthritis and colitis, demonstrating marked improvement. Three patients had complete resolution of lymphadenopathy and splenomegaly and all patients had a reduction in double negative T cells, a population hallmark of the disease. Based on these significant responses, we recommend that sirolimus be considered as second-line therapy for patients with steroid-refractory disease. PMID:19208097

  9. Synergistic defects of novo FAS and homozygous UNC13D leading to autoimmune lymphoproliferative syndrome-like disease: A 10-year-old Chinese boy case report.

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    Gu, Hao; Ma, Jie; Chen, Zhenping; Wang, Jing; Zhang, Rui; Wu, Runhui

    2018-06-01

    Autoimmune lymphoproliferative syndrome (ALPS) usually presents in childhood with fever, nonmalignant splenomegaly and lymphadenopathy along with hemocytopenia. This case report describes a 10-year-old boy presenting with signs of autoimmune disease, splenomegaly, hepatomegaly and resistant hemocytopenia. Sirolimus controlled the relapsed thrombocytopenia after splenectomy. Sequencing of the FAS gene identified two spontaneous heterozygous mutations (c.234 T > G, p.D78E) (c.236dupA, p.P80Tfs*26). The boy's homozygous missense variation (c.2588G > A, p.G863D) (rs140184929) in UNC13D gene had been identified as being related to familial hemophagocytic lymphohistiocytosis (FHL). TCRαβ + CD4/CD8 double-negative T cells (markers of ALPS) were not significantly increased from the outset. Elevated cytokines, such as interferon (IFN)-γ, interleukin (IL)-6 and tumor necrosis factor α decreased to normal levels after splenectomy whereas IL-10 remained high. Immunological analysis of the patient revealed a marked depletion of forkhead-box P3 + expressing regulatory T cells (Treg) and Th17 cells. The obtained data demonstrate that mutations to FAS and UNC13D which result in overwhelming T-cell and macrophage activation, one associated with inhibited Treg cell development and a severe ALPS-like symptom. Therefore, we propose that variations of UND13D may be a risk factor of ALPS development. Copyright © 2017. Published by Elsevier B.V.

  10. LYMPHOPROLIFERATIVE SYNDROMES ASSOCIATED WITH HUMAN HERPESVIRUS-6A AND HUMAN HERPESVIRUS-6B

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    Eva Eliassen

    2018-05-01

    Full Text Available Human herpesvirus 6A and 6B (HHV-6A and HHV-6B have been noted since their discovery for their T-lymphotropism. Although it has proven difficult to determine the extent to which HHV-6A and HHV-6B are involved in the pathogenesis of many diseases, evidence suggests that primary infection and reactivation of both viruses may induce or contribute to the progression of several lymphoproliferative disorders, ranging from benign to malignant and including infectious mononucleosis-like illness, drug induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS, and nodular sclerosis Hodgkin’s lymphoma. Herein, we discuss the conditions associated with the lymphoproliferative capacity of HHV-6, as well as the potential mechanisms behind them. Continued exploration on this topic may add to our understanding of the interactions between HHV-6 and the immune system and may open the doors to more accurate diagnosis and treatment of certain lymphoproliferative disorders.

  11. Autoimmune lymphoproliferative syndrome and non-Hodgkin lymphoma: what 18F-fluorodeoxyglucose positron emission tomography/computed tomography can do in the management of these patients? Suggestions from a case report.

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    Cistaro, A; Pazè, F; Durando, S; Cogoni, M; Faletti, R; Vesco, S; Vallero, S; Quartuccio, N; Treglia, G; Ramenghi, U

    2014-01-01

    A young patient with undefined autoimmune lymphoproliferative syndrome (ALPS-U) and low back pain underwent a CT and MRI study that showed enhancing vertebral lesions, some pulmonary nodules and diffuse latero-cervical lymphadenopathy. A (18)F-FDG-PET/CT scan showed many areas of intense (18)F-FDG uptake in multiple vertebrae, in some ribs, in the sacrum, in the liver, in both lungs, in multiple lymph nodes spread in the cervical, thoracic and abdominal chains. A bone marrow biopsy showed a "lymphomatoid granulomatosis", a rare variant of B-cell non-Hodgkin lymphoma (NHL). After the treatment, the (18)F-FDG-PET/CT scan showed a complete metabolic response. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  12. Splenectomy in two children with autoimmune lymphoproliferative syndrome and massive splenomegaly

    DEFF Research Database (Denmark)

    Glerup, Mia; Thelle, Thomas; Grønbaek, Kirsten

    2009-01-01

    Treatment of patients with ALPS has varied but presently there is no consensus about the optimal therapy. Splenectomy is an option but data regarding the postsplenectomy outcome in pediatric ALPS patients remain very limited. We present two children who suffered from anemia and physical discomfort...

  13. Study Provides Insights into Diagnosis, Treatment of Rare Immune Disease: Autoimmmune Lymphoproliferative Syndrome ...

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    ... in the blood. While DNT cells are a hallmark of ALPS, scientists do not fully understand their ... higher-than-average risk of developing lymphoma, or cancer of the lymph nodes. In the current study, ...

  14. An animal model for human EBV-associated hemophagocytic syndrome: herpesvirus papio frequently induces fatal lymphoproliferative disorders with hemophagocytic syndrome in rabbits.

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    Hayashi, K; Ohara, N; Teramoto, N; Onoda, S; Chen, H L; Oka, T; Kondo, E; Yoshino, T; Takahashi, K; Yates, J; Akagi, T

    2001-04-01

    Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS) is often associated with fatal infectious mononucleosis. However, the animal model for EBV-AHS has not been developed. We reported the first animal model for EBV-AHS using rabbits infected with EBV-related herpesvirus of baboon (HVP). Eleven of 13 (85%) rabbits inoculated intravenously with HVP-producing cells developed fatal lymphoproliferative disorders (LPD) between 22 and 105 days after inoculation. LPD was also accompanied by hemophagocytic syndrome (HPS) in nine of these 11 rabbits. The peroral spray of cell-free HVP induced the virus infection with increased anti-EBV-viral capsid antigen-IgG titers in three of five rabbits, and two of these three infected rabbits died of LPD with HPS. Autopsy revealed hepatosplenomegaly and swollen lymph nodes. Atypical lymphoid T cells expressing EBV-encoded small RNA-1 infiltrated diffusely in many organs, frequently involving the lymph nodes, spleen, and liver. Hemophagocytic histiocytosis was observed in the lymph nodes, spleen, bone marrow, and thymus. HVP-DNA was detected in the tissues and peripheral blood from the infected rabbits by polymerase chain reaction or Southern blot analysis. Reverse transcriptase-polymerase chain reaction revealed both HVP-EBNA1 and HVP-EBNA2 transcripts, suggesting latency type III infection. These data indicate that the high rate of rabbit LPD with HPS induction is caused by HVP. This system is useful for studying the pathogenesis, prevention, and treatment of human EBV-AHS.

  15. Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome

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    Vavassori, Stefano; Galson, Jacob D; Trück, Johannes; van den Berg, Anke; Tamminga, Rienk Y J; Magerus-Chatinet, Aude; Pellé, Olivier; Camenisch Gross, Ulrike; Marques Maggio, Ewerton; Prader, Seraina; Opitz, Lennart; Nüesch, Ursina; Mauracher, Andrea; Volkmer, Benjamin; Speer, Oliver; Suda, Luzia; Röthlisberger, Benno; Zimmermann, Dieter Robert; Müller, Rouven; Diepstra, Arjan; Visser, Lydia; Haralambieva, Eugenia; Neven, Bénédicte; Rieux-Laucat, Frédéric; Pachlopnik Schmid, Jana

    2017-01-01

    FAS-dependent apoptosis in Vδ1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations.Rapamycin and methylprednisolone resistance should prompt clinicians to look for Vδ1 T cell proliferation in ALPS-FAS patients.

  16. X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency May Not Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis

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    Nesrin Gulez

    2011-01-01

    Full Text Available The X-linked lymphoproliferative syndrome (XLP is a rare, inherited immunodeficiency characterized by recurrent episodes of hemophagocytic lymphohistiocytosis, hypogammaglobulinemia, and/or lymphomas. Recently, X-linked inhibitor of apoptosis (XIAP/BIRC4 gene defects, in families with XLP but without SH2D1A gene defects, has been defined. The distinction from primary immunodeficiencies with a defined genetic cause is mandatory. A six-year-old male patient was admitted with the complaints of persistent general lymphadenopathy, for two years had fever, bilateral cervical multiple microlymphadenopathy, hepatic/splenic enlargement with laboratory findings as decreased serum immunoglobulins, negative EBV VCA IgM (viral capsid antigen and anti-EBV EA (antibody to early D antigen, positive EBV VCA IgG (viral capsid antigen and EBV EBNA (antibody to nuclear antigen. SH2D1A gene analysis was negative. XIAP/BIRC4 sequencing revealed two novel single nucleotide variants (exon 7, 1978G > A, and 1996T > A in the 3′UTR of the gene in both patient and mother which were not disease causing. XIAP protein expression was found to be normal. The clinical and laboratory resemblance, no gene mutations, and normal XIAP protein expression led us to think that there may be another responsible gene for XLP. The patient will to be followed up as CVID until he presents new diagnostic signs or until the identification of a new gene.

  17. Granulomatous Lymphoproliferative Disorders: Granulomatous Slack Skin and Lymphomatoid Granulomatosis.

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    Gangar, Pamela; Venkatarajan, Sangeetha

    2015-07-01

    Granulomatous cutaneous T-cell lymphomas (CTCL) and lymphomatoid granulomatosis are considered granulomatous lymphoproliferative disorders. The most common types of granulomatous CTCL are granulomatous mycosis fungoides and granulomatous slack skin. Lymphomatoid granulomatosis is a rare Epstein-Barr virus driven lymphoproliferative disorder. This article reviews the etiopathogenesis, clinical presentation, systemic associations, and management of both granulomatous slack skin syndrome and lymphomatoid granulomatosis. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Frequency of a FAS ligand gene variant associated with inherited feline autoimmune lymphoproliferative syndrome in British shorthair cats in New Zealand.

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    Aberdein, D; Munday, J S; Dittmer, K E; Heathcott, R W; Lyons, L A

    2017-11-01

    AIMS To determine the frequency of the FAS-ligand gene (FASLG) variant associated with feline autoimmune lymphoproliferative syndrome (FALPS) and the proportion of carriers of the variant in three British shorthair (BSH) breeding catteries in New Zealand. METHODS Buccal swabs were collected from all cats in two BSH breeding catteries from the South Island and one from the North Island of New Zealand. DNA was extracted and was tested for the presence of the FASLG variant using PCR. Cats with the FASLG variant were identified and the frequency of the FASLG variant allele calculated. Pedigree analysis was performed and inbreeding coefficients were calculated for cats with the FASLG variant. RESULTS Of 32 BSH cats successfully tested for the presence of the FASLG variant, one kitten (3%) was homozygous (FALPS-affected), and seven (22%) cats were heterozygous (carriers) for the FASLG variant allele, and 24 (75%) cats were homozygous for the wild type allele. The overall frequency of the FASLG variant allele in these 32 cats was 0.14. Cats carrying the FASLG variant were from all three breeding catteries sampled, including two catteries that had not previously reported cases of FALPS. Pedigree analysis revealed common ancestry of FALPS-affected and carrier cats within six generations, as well as frequent inbreeding, with inbreeding coefficients >0.12 for five cats with the FASLG variant. CONCLUSIONS AND CLINICAL RELEVANCE There was a high frequency of the FASLG variant allele (0.14) in this small sample of BSH cats, with 22% of healthy cats identified as carriers of the FASLG variant. For an inherited disease, lethal at a young age, in a small population in which inbreeding is common, these results are significant. To prevent future cases of disease and stop further spread of the FASLG variant allele within the BSH population in New Zealand, it is recommended that all BSH and BSH-cross cats be tested for the presence of the FASLG variant before mating. Cats identified as

  19. Cutaneous lymphoproliferative disorder complicating infectious mononucleosis in an immunosuppressed patient.

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    Owen, Cindy England; Callen, Jeffrey P; Bahrami, Soon

    2011-01-01

    Infectious mononucleosis is the syndrome produced by primary infection with Epstein-Barr virus during adolescence or early adulthood. In immunosuppressed individuals, depressed T-cell function allows the Epstein-Barr virus-driven B-cell proliferation to continue unabated, potentially leading to a lymphoproliferative disorder. A 15-year-old girl with a history of ulcerative colitis treated with 6-mercaptopurine and mesalamine presented with the acute onset of a rapidly enlarging, ulcerative nodule on her left lower eyelid 4 weeks following recovery from infectious mononucleosis. The biopsy revealed an Epstein-Barr virus-positive lymphoproliferative disorder. Systemic disease was absent. Following discontinuation of 6-mercaptopurine, the patient was treated with two courses of intravenous cyclophosphamide. The lesion resolved completely and she remains disease free at 14 months following diagnosis. We report a solitary cutaneous lesion of an immunosuppression-related lymphoproliferative disorder (IR-LPD) occurring as a complication of infectious mononucleosis, and review the pathogenesis and reported cases of Epstein-Barr virus-related immunosuppression-related lymphoproliferative disorder arising in the setting of inflammatory bowel disease. It is important for dermatologists and dermatopathologists to be aware of the occurrence of IR-LPD in patients being treated for inflammatory conditions, including inflammatory bowel disease. Given the role of primary infection with Epstein-Barr virus in the development of IR-LPD, consideration may be given to assessing Epstein-Barr virus status prior to initiating immunosuppressive therapy in young patients. © 2010 Wiley Periodicals, Inc.

  20. Rabbit model for human EBV-associated hemophagocytic syndrome (HPS): sequential autopsy analysis and characterization of IL-2-dependent cell lines established from herpesvirus papio-induced fatal rabbit lymphoproliferative diseases with HPS.

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    Hayashi, Kazuhiko; Jin, Zaishun; Onoda, Sachiyo; Joko, Hiromasa; Teramoto, Norihiro; Ohara, Nobuya; Oda, Wakako; Tanaka, Takehiro; Liu, Yi-Xuan; Koirala, Tirtha Raj; Oka, Takashi; Kondo, Eisaku; Yoshino, Tadashi; Takahashi, Kiyoshi; Akagi, Tadaatsu

    2003-05-01

    Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS) is often associated with fatal infectious mononucleosis or T-cell lymphoproliferative diseases (LPD). To elucidate the true nature of fatal LPD observed in Herpesvirus papio (HVP)-induced rabbit hemophagocytosis, reactive or neoplastic, we analyzed sequential development of HVP-induced rabbit LPD and their cell lines. All of the seven Japanese White rabbits inoculated intravenously with HVP died of fatal LPD 18 to 27 days after inoculation. LPD was also accompanied by hemophagocytic syndrome (HPS) in five of these seven rabbits. Sequential autopsy revealed splenomegaly and swollen lymph nodes, often accompanied by bleeding, which developed in the last week. Atypical lymphoid cells infiltrated many organs with a "starry sky" pattern, frequently involving the spleen, lymph nodes, and liver. HVP-small RNA-1 expression in these lymphoid cells was clearly demonstrated by a newly developed in situ hybridization (ISH) system. HVP-ISH of immunomagnetically purified lymphoid cells from spleen or lymph nodes revealed HVP-EBER1+ cells in each CD4+, CD8+, or CD79a+ fraction. Hemophagocytic histiocytosis was observed in the lymph nodes, spleen, bone marrow, and thymus. HVP-DNA was detected in the tissues and peripheral blood from the infected rabbits by PCR or Southern blot analysis. Clonality analysis of HVP-induced LPD by Southern blotting with TCR gene probe revealed polyclonal bands, suggesting polyclonal proliferation. Six IL-2-dependent rabbit T-cell lines were established from transplanted scid mouse tumors from LPD. These showed latency type I/II HVP infection and had normal karyotypes except for one line, and three of them showed tumorigenicity in nude mice. These data suggest that HVP-induced fatal LPD in rabbits is reactive polyclonally in nature.

  1. Therapeutic trials for a rabbit model of EBV-associated Hemophagocytic Syndrome (HPS): effects of vidarabine or CHOP, and development of Herpesvirus papio (HVP)-negative lymphomas surrounded by HVP-infected lymphoproliferative disease.

    Science.gov (United States)

    Hayashi, K; Joko, H; Koirala, T R; Onoda, S; Jin, Z-S; Munemasa, M; Ohara, N; Oda, W; Tanaka, T; Oka, T; Kondo, E; Yoshino, T; Takahashi, K; Yamada, M; Akagi, T

    2003-10-01

    Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS), which is often associated with fatal infectious mononucleosis or T-cell lymphoproliferative diseases (LPD), is a distinct disease characterized by high mortality. Treatment of patients with EBV-AHS has proved challenging. To develop some therapeutic interventions for EBV-AHS, we examined the effectiveness of an antiviral agent (vidarabine) or chemotherapy (CHOP), using a rabbit model for EBV-AHS. Fourteen untreated rabbits were inoculated intravenously with cell-free virions of the EBV-like virus Herpesvirus papio (HVP). All of the rabbits died of HVP-associated (LPD) and hemophagocytic syndrome (HPS) between 21 and 31 days after inoculation. Furthermore, three HVP-infected rabbits treated with vidarabine died between days 23 and 28 after inoculation, and their clinicopathological features were no different from those of untreated rabbits, indicating that this drug is not effective at all to treat HVP-induced rabbit LPD and HPS. Three of the infected rabbits that were treated with one course, with an incomplete set of three courses, or with three full courses of CHOP treatment died of HVP-induced LPD and HPS with a bleeding tendency and/or with opportunistic infections. They died on the 26th, 62nd and 105th day after virus inoculation, respectively. CHOP treatment transiently suppressed the HVP-induced LPD and contributed to the prolonged survival time of two infected rabbits. However, it did not remove all of the HVP-infected cells from the infected rabbits, and residual HVP-infected lymphocytes caused recurrences of rabbit LPD and HPS. The most interesting finding of this experiment was observed in the infected rabbit with the longest survival time of 105 days: HVP-negative lymphomas surrounded by HVP-induced LPD developed in the larynx and ileum of this rabbit, causing an obstruction of the lumen. We concluded that these were not secondary lymphomas caused by CHOP treatment, because no suspicious

  2. X-Linked Lymphoproliferative Disease Presenting as Pancytopenia in a 10-Month-Old Boy

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    S. Nicole Chadha

    2010-01-01

    Full Text Available X-linked lymphoproliferative disease, also known as Duncan's syndrome, is a rare genetic disorder that causes exaggerated immune responses to Epstein-Barr virus (EBV infection and often leads to death. Patient presentation varies but can include signs and symptoms typical of EBV, pancytopenia, and fulminant hepatitis.

  3. Post-transplant lymphoproliferative disorders.

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    Singavi, Arun K; Harrington, Alexandra M; Fenske, Timothy S

    2015-01-01

    Post-transplant lymphoproliferative disorders (PTLD) are a serious complication after solid organ or allogeneic hematopoietic stem cell transplantation and include a range of diseases from benign proliferations to malignant lymphomas. Risk factors for developing PTLD include Epstein-Barr virus (EBV) infection, recipient age, transplanted organ, type of immunosuppression, and genetics. Uncontrolled proliferation of EBV-infected B cells is implicated in EBV-positive PTLD, whereas the pathogenesis of EBV-negative PTLD may be similar to non-Hodgkin's lymphoma in the general population. The World Health Organization (WHO) classifies PTLD into four categories: early lesions, polymorphic PTLD, monomorphic PTLD, and classical Hodgkin's lymphoma (cHL). Treatment is aimed at cure of PTLD, while maintaining transplanted organ function. However, there are no established guidelines for the treatment of PTLD. Immune suppression reduction (ISR) is the first line of treatment in most cases, with more recent data suggesting early use of rituximab. In more aggressive forms of PTLD, upfront chemotherapy may offer a better and more durable response. Sequential therapy using rituximab followed by chemotherapy has demonstrated promising results and may establish a standard of care. Novel therapies including anti-viral agents, adoptive immunotherapy, and monoclonal antibodies targeting cytokines require further study in the prevention and treatment of PTLD.

  4. Síndrome linfoproliferativo ligado al cromosoma X, infección por el virus EBV y defectos en la regulación de la citotoxicidad linfocitaria X-linked lymphoproliferative syndrome, EBV infection and impaired regulation of cell-mediated cytotoxicity

    Directory of Open Access Journals (Sweden)

    A. Malbrán

    2003-01-01

    Full Text Available La deficiencia del gen SH2D1A que codifica para la proteína reguladora SAP trae aparejada la activación incontrolada de la vía de activación linfocitaria señalizada por SLAM (molécula señaladora de la activación linfocitaria. Es una inmunodeficiencia ligada al cromosoma X (XLP que se pone en evidencia cuando los pacientes portadores de mutaciones en el gen se enfrentan con el virus de Epstein Barr, desarrollando una mononucleosis infecciosa fulminante. Algunos pacientes desarrollan un síndrome linfoproliferativo fatal; los que sobreviven pueden presentar hipogammaglobulinemia severa y mayor frecuencia de neoplasia hematológica que la población normal. En esta revisión se discuten los mecanismos inmuno-regulatorios involucrados en el desarrollo de la patología mencionada, así como la participación de diferentes células efectoras de la respuesta inmune (linfocitos CD8 citotóxicos, células NK.Mutations in SH2D1A, a gene that codifies for the regulatory protein SAP, result in uncontrolled activation of the SLAM (signaling lymphocyte-activation molecule pathway. This X-linked immunodeficiency becomes evident when the patients are infected with Epstein Barr virus (EBV and develop a fulminant form of infectious mononucleosis leading to a lymphoproliferative syndrome that is often fatal (X-linked lymphoproliferative syndrome, XLP. In those who survive, hypogammaglobulinemia and oncohematologic diseases are frequently observed. In this revision, the immuno-regulatory mechanisms involved in XLP immunopathology and the role of different effector cells (CD8 T lymphocytes, NK cells are discussed.

  5. Mutlifocal osseous posttransplantation lymphoproliferative disorder: case report

    International Nuclear Information System (INIS)

    Lo, Ryan; Michalicek, Zachary; Lazarus, Martin

    2015-01-01

    Posttransplant lymphoproliferative disorder (PTLD) is a known complication of organ transplantation, but musculoskeletal involvement of PTLD remains very rare. We present a case of recurrent PTLD of the bone in a heart transplant patient that was misdiagnosed as gout for several years. There are only a few cases of osseous PTLD in the literature, and we hope to better characterize its imaging findings on multiple imaging modalities. (orig.)

  6. Mutlifocal osseous posttransplantation lymphoproliferative disorder: case report

    Energy Technology Data Exchange (ETDEWEB)

    Lo, Ryan [University of Chicago, Department of Radiology, Chicago, IL (United States); Michalicek, Zachary [Northshore University Healthsystems, Department of Pathology, Evanston, IL (United States); Lazarus, Martin [Northshore University Healthsystems, Department of Radiology, Evanston, IL (United States)

    2015-02-14

    Posttransplant lymphoproliferative disorder (PTLD) is a known complication of organ transplantation, but musculoskeletal involvement of PTLD remains very rare. We present a case of recurrent PTLD of the bone in a heart transplant patient that was misdiagnosed as gout for several years. There are only a few cases of osseous PTLD in the literature, and we hope to better characterize its imaging findings on multiple imaging modalities. (orig.)

  7. Genetics Home Reference: X-linked lymphoproliferative disease

    Science.gov (United States)

    ... my area? Other Names for This Condition Duncan disease Epstein-Barr virus-induced lymphoproliferative disease in males familial fatal ... the proapoptotic SAP function in X-linked lymphoproliferative disease aggravates Epstein-Barr virus (EBV) induced mononucleosis and promotes lymphoma development. ...

  8. Lacrimal sac lymphoproliferative lesion: case report.

    Science.gov (United States)

    Coloma-González, I; Ruíz-García, L; Ceriotto, A; Corredor-Casas, S; Salcedo-Casillas, G

    2015-03-01

    The case is presented of a 51 year-old woman with a firm mass at the medial canthus of the right eye of five years onset. A low-grade lymphoproliferative lesion (reactive lymphoid hyperplasia) was diagnosed from an excisional biopsy Lacrimal sac tumors are rare, with a peak incidence in the fifth decade of life. The initial clinical features are epiphora and medial canthus swelling. As it mimics nasolacrimal duct obstruction, up to 40% of these tumors are misdiagnosed until undergoing surgery. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  9. ALP - blood test

    Science.gov (United States)

    ... Tissues with higher amounts of ALP include the liver, bile ducts, and bone. A blood test can be done ... and the A.D.A.M. Editorial team. Bile Duct Diseases Read more Bone Diseases Read more Liver Function Tests Read more A.D.A.M., ...

  10. Post-transplant lymphoproliferative disease in liver transplant recipients

    Directory of Open Access Journals (Sweden)

    Mercedes Rubio-Manzanares-Dorado

    Full Text Available Introduction: Post-transplant lymphoproliferative syndrome (PTLD is a rare and potentially life-threatening complication after liver transplantation. The aim of this study was to analyze the clinicopathologic features related to PTLD in a single institution after liver transplantation. Methods: Observational study where we have retrospectively analyzed 851 cases who underwent liver transplantation. Ten cases have developed PTLD. Their clinical-pathological characteristics and the treatment received have been analyzed. Results: PTLD incidence was 1.2% (10/851. The mean time from liver transplantation to PTLD diagnosis was 36 months (range 1.2 to 144 months. PTLD localization was extranodal in all cases, the most frequent location being intestinal. Seven cases showed a monomorphic lymphoma which in all cases was differentiated B cell lymphomas. Fifty per cent of the series were seropositive for Epstein-Barr virus. Five patients were alive at the time of the review. Among these patients, we observed three cases of complete remission and two cases of disease stabilization. The death rate was higher in the first year after diagnosis of PTLD. Conclusion: PTLD is a rare complication after liver transplantation, but it may pose a threat to the life of a liver transplant recipient. It is essential to identify patients at risk, to establish an early diagnosis and treatment that can change the outcome of the disease.

  11. Posttransplantation lymphoproliferative disease involving the pituitary gland.

    Science.gov (United States)

    Meriden, Zina; Bullock, Grant C; Bagg, Adam; Bonatti, Hugo; Cousar, John B; Lopes, M Beatriz; Robbins, Mark K; Cathro, Helen P

    2010-11-01

    Posttransplantation lymphoproliferative disorders (PTLD) are heterogeneous lesions with variable morphology, immunophenotype, and molecular characteristics. Multiple distinct primary lesions can occur in PTLD, rarely with both B-cell and T-cell characteristics. Lesions can involve both grafted organs and other sites; however, PTLD involving the pituitary gland has not been previously reported. We describe a patient who developed Epstein-Barr virus-negative PTLD 13 years posttransplantation involving the terminal ileum and pituitary, which was simultaneously involved by a pituitary adenoma. Immunohistochemistry of the pituitary lesion showed expression of CD79a, CD3, and CD7 with clonal rearrangements of both T-cell receptor gamma chain (TRG@) and immunoglobulin heavy chain (IGH@) genes. The terminal ileal lesion was immunophenotypically and molecularly distinct. This is the first report of pituitary PTLD and illustrates the potentially complex nature of PTLD. Copyright © 2010 Elsevier Inc. All rights reserved.

  12. ALPS: A Linear Program Solver

    Science.gov (United States)

    Ferencz, Donald C.; Viterna, Larry A.

    1991-01-01

    ALPS is a computer program which can be used to solve general linear program (optimization) problems. ALPS was designed for those who have minimal linear programming (LP) knowledge and features a menu-driven scheme to guide the user through the process of creating and solving LP formulations. Once created, the problems can be edited and stored in standard DOS ASCII files to provide portability to various word processors or even other linear programming packages. Unlike many math-oriented LP solvers, ALPS contains an LP parser that reads through the LP formulation and reports several types of errors to the user. ALPS provides a large amount of solution data which is often useful in problem solving. In addition to pure linear programs, ALPS can solve for integer, mixed integer, and binary type problems. Pure linear programs are solved with the revised simplex method. Integer or mixed integer programs are solved initially with the revised simplex, and the completed using the branch-and-bound technique. Binary programs are solved with the method of implicit enumeration. This manual describes how to use ALPS to create, edit, and solve linear programming problems. Instructions for installing ALPS on a PC compatible computer are included in the appendices along with a general introduction to linear programming. A programmers guide is also included for assistance in modifying and maintaining the program.

  13. The radiographic findings of lymphoproliferative disorders of the lung

    International Nuclear Information System (INIS)

    Song Wei; Li Liping; Yan Hongzhen

    2002-01-01

    Objective: To study the radiographic findings of lymphoproliferative disorders of the lung. Methods: Twenty-five patients with lymphoproliferative disorders of the lung were examined by X-ray film, tomography, and CT. Results: Multiple and mediastinal lymphadenopathy were observed in 2 patients with pulmonary pseudolymphoma. Multiple nodules or masses were observed in 4 patients with pulmonary lymphomatoid granulomatosis. Hilar and mediastinal lymphadenopathy was observed in each patient with angioimmunoblastic lymphadenopathy, 2 patients had multiple nodules or masses, 8 patients had single or multiple patchy infiltrations, 10 had diffuse interstitial infiltrations. 3 patients with Castlemen' disease had a mass in the mediastinum, and another patient had mediastinal lymphadenopathy. Conclusion: Radiographic findings of lymphoproliferative disorders of the lung are varied, and the final diagnosis relies on pathology

  14. EBV-Associated Lymphoproliferative Disorder and Hemophagocytic Lymphohistiocytosis in a Patient with Severe Celiac Disease

    Directory of Open Access Journals (Sweden)

    John Jacob Kinross-Wright

    2018-01-01

    Full Text Available Background. Epstein-Barr virus- (EBV- associated lymphoproliferative disease (LPD is a rare condition, usually occurring in immunocompromised patients. We report a case of EBV-associated LPD in a patient with severe celiac disease, the first report to describe this syndrome in a patient with this diagnosis. Case Summary. A 69-year-old Caucasian woman with recent diagnosis of celiac sprue presented to our hospital with persistent diarrhea, abdominal pain, weight loss, and fatigue despite adherence to gluten-free diet for a number of weeks prior to presentation. She underwent evaluation for occult malignancy and was found to have diffuse intra-abdominal mesenteric lymphadenopathy on CT scan. Biopsy of mesenteric nodes revealed an EBV positive, CD20 positive mixed lymphoproliferative process with T-cell predominance, but without a monoclonal cell population felt to be consistent with EBV-associated LPD. Bone marrow biopsy revealed hemophagocytic lymphohistiocytosis, complicating her course. She was treated with steroids and rituximab but continued to decline, eventually developing MSSA bacteremia and succumbing to her disease. Conclusion. To our knowledge, this is the first report of the constellation of celiac sprue, EBV-associated LPD, and hemophagocytic lymphohistiocytosis. Providers caring for patients with severe, uncontrolled celiac disease and adenopathy should consider EBV-associated LPD.

  15. ALPS - A LINEAR PROGRAM SOLVER

    Science.gov (United States)

    Viterna, L. A.

    1994-01-01

    Linear programming is a widely-used engineering and management tool. Scheduling, resource allocation, and production planning are all well-known applications of linear programs (LP's). Most LP's are too large to be solved by hand, so over the decades many computer codes for solving LP's have been developed. ALPS, A Linear Program Solver, is a full-featured LP analysis program. ALPS can solve plain linear programs as well as more complicated mixed integer and pure integer programs. ALPS also contains an efficient solution technique for pure binary (0-1 integer) programs. One of the many weaknesses of LP solvers is the lack of interaction with the user. ALPS is a menu-driven program with no special commands or keywords to learn. In addition, ALPS contains a full-screen editor to enter and maintain the LP formulation. These formulations can be written to and read from plain ASCII files for portability. For those less experienced in LP formulation, ALPS contains a problem "parser" which checks the formulation for errors. ALPS creates fully formatted, readable reports that can be sent to a printer or output file. ALPS is written entirely in IBM's APL2/PC product, Version 1.01. The APL2 workspace containing all the ALPS code can be run on any APL2/PC system (AT or 386). On a 32-bit system, this configuration can take advantage of all extended memory. The user can also examine and modify the ALPS code. The APL2 workspace has also been "packed" to be run on any DOS system (without APL2) as a stand-alone "EXE" file, but has limited memory capacity on a 640K system. A numeric coprocessor (80X87) is optional but recommended. The standard distribution medium for ALPS is a 5.25 inch 360K MS-DOS format diskette. IBM, IBM PC and IBM APL2 are registered trademarks of International Business Machines Corporation. MS-DOS is a registered trademark of Microsoft Corporation.

  16. Native kidney posttransplant lymphoproliferative disorder in a renal transplant recipient.

    Science.gov (United States)

    Chandra, Abhilash; Kaul, Anupama; Aggarwal, Vinita; Srivastava, Divya

    2017-01-01

    Compared with the general population, cancer risk in kidney transplant recipients is much higher. In the present study, we report a patient who was diagnosed with posttransplant lymphoproliferative disorder (PTLD) and had a fulminant course, dying within few days of diagnosis. This case report highlights the importance of timely detection and treatment of PTLD as it is associated with high mortality rate.

  17. Native kidney posttransplant lymphoproliferative disorder in a renal transplant recipient

    OpenAIRE

    Abhilash Chandra; Anupama Kaul; Vinita Aggarwal; Divya Srivastava

    2017-01-01

    Compared with the general population, cancer risk in kidney transplant recipients is much higher. In the present study, we report a patient who was diagnosed with posttransplant lymphoproliferative disorder (PTLD) and had a fulminant course, dying within few days of diagnosis. This case report highlights the importance of timely detection and treatment of PTLD as it is associated with high mortality rate.

  18. Characterization of primary cutaneous CD8+/CD30+ lymphoproliferative disorders.

    Science.gov (United States)

    Martires, Kathryn J; Ra, Seong; Abdulla, Farah; Cassarino, David S

    2015-11-01

    CD30 primary cutaneous lymphoproliferative diseases include both lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (PCALCL). The neoplastic cell of most primary CD30 lymphoproliferative disorders is CD4 positive. The terminology LyP "type D" has been used to describe a growing number of cases of LyP with a predominantly CD8 infiltrate. PCALCL with a CD8 phenotype has also been described, which presents a particularly difficult diagnostic and management challenge, given the difficulty in distinguishing it histologically from other cytotoxic lymphomas such as primary cutaneous aggressive epidermotropic CD8 cytotoxic T-cell lymphoma and CD8 gamma/delta and natural killer/T-cell lymphoma. We report 7 additional cases of these rare cutaneous CD8/CD30 lymphoproliferative disorders. We also present a unique case of CD8/CD30 LyP with histologic similarities to LyP type B. In all 7 of our cases of CD8 LyP and CD8 anaplastic large cell lymphoma, we found focal to diffuse MUM-1 positivity. We propose that MUM-1 may represent an adjunctive marker for CD8 lymphoproliferative disease. Finally, we review the current literature on cases of CD8 LyP and PCALCL. For the 106 cases examined, we found similar clinical and histologic features to those reported for traditional CD4CD30 LyP and PCALCL.

  19. Immune-mediated neuropathy with Epstein-Barr virus-positive T-cell lymphoproliferative disease.

    Science.gov (United States)

    Hattori, Takaaki; Arai, Ayako; Yokota, Takanori; Imadome, Ken-Ichi; Tomimitsu, Hiroyuki; Miura, Osamu; Mizusawa, Hidehiro

    2015-01-01

    A 47-year-old man with Epstein-Barr virus (EBV)-positive T/NK- cell lymphoproliferative disease (EBV-T/NK-LPD) developed acute-onset weakness. A nerve conduction study showed a conduction block in both the proximal and most distal segments. Although the patient's neuropathy transiently responded to intravenous immunoglobulin, it was progressive for at least 25 days until the start of prednisolone (PSL) administration, after which it remarkably improved. The neuropathy further improved after allogeneic bone marrow transplantation (BMT). The present patient's clinical course is not consistent with that of typical Guillain-Barré syndrome. This case suggests that EBV-T/NK-LPD can cause progressive immune-mediated neuropathy as a result of chronic EBV antigen presentation and can be treated with PSL and BMT.

  20. CD30+ lymphoproliferative disorder with spindle-cell morphology.

    Science.gov (United States)

    Martires, Kathryn J; Cohen, Brandon E; Cassarino, David S

    2016-11-01

    Lymphomatoid papulosis (LyP) is classified as a CD30+ primary cutaneous lymphoproliferative disease. The phenotypic variability along the spectrum of CD30+ lymphoproliferative diseases is highlighted by the distinct histologic subtypes of LyP types A, B, C, and the more recently described types D, E, and F. We report the case of an elderly woman with a clinical presentation and histopathologic findings consistent with LyP, whose atypical CD30+ infiltrate uniquely demonstrated a spindle-cell morphology. To our knowledge, this is the first reported case of LyP characterized by CD30+ spindle-shaped cells, and may represent a new and distinct histologic variant of LyP. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Native kidney posttransplant lymphoproliferative disorder in a renal transplant recipient

    Directory of Open Access Journals (Sweden)

    Abhilash Chandra

    2017-01-01

    Full Text Available Compared with the general population, cancer risk in kidney transplant recipients is much higher. In the present study, we report a patient who was diagnosed with posttransplant lymphoproliferative disorder (PTLD and had a fulminant course, dying within few days of diagnosis. This case report highlights the importance of timely detection and treatment of PTLD as it is associated with high mortality rate.

  2. How steep are the Alps?

    Science.gov (United States)

    Robl, Jörg; Prasicek, Günther; Stüwe, Kurt; Hergarten, Stefan

    2014-05-01

    The topography of the European Alps reflects continental collision, crustal thickening and buoyancy driven surface uplift, overprinted by erosional processes. Topographic gradients generally steepen from the valley floors up to about 1500 m - 2000 m followed by an unexpected decrease in slope up to about 2900 m and a further increase to the highest summits of the range. Several studies have interpreted this pattern and the accompanied maximum in the hypsometric curve in terms of either the critical slope stability angle, the prematurity of the Alps caused by recent tectonic uplift, or the effect of the glacial "buzz saw" related to the Pleistocene glaciation cycles. There is consensus that the lithological inventory represents a first order parameter for the steepness of fluvial channels and the angle of hillslopes in steady state and that the response time of a transient landscape is controlled by lithology. In this study we systematically explore the slope-elevation distributions for several hundred continuous domains of the major structural units of the Alps. For this, we apply a novel numerical code to determine the predominant cause for the observed peculiar topography. We compare adjacent alpine domains with contrasting lithology to explore lithological effects on the limiting slope stability angle. We analyze domains with different lithology in the non-glaciated parts of the orogen to highlight the state of maturity related to a recent uplift event. We evaluate the glacial effects on the landscape by the comparison of areas belonging to the same structural units but affected by a variable amount of glacial imprint. The results show that lithology has a major impact on the morphometric characteristics of the European Alps. Adjacent but different structural units show a significant variability in their slope-elevation distributions although they have experienced the same uplift history and the same amount of glacial imprint. This suggests that the response

  3. Any Light Particle Search (ALPS)

    Science.gov (United States)

    Spector, Aaron; Any Light Particle Search (ALPS) Collaboration

    2016-03-01

    High power laser fields enabled by technologies developed for ground-based gravitational-wave observatories open up new opportunities for fundamental physics studies. One of these options is the search for axions and axion-like particles in a pure laboratory experiment. The axion is a solution to the strong CP-problem and a potential dark matter candidate. The axion has also been proposed as an additional channel to cool stars as well as a potential explanation for the TeV transparency problem. The German-US ALPS collaboration is setting up a light-shining-through-walls (LSW) experiment at DESY. LSW experiments are based on the simple idea that a high power laser field traversing a static magnetic field will transform partly into a relativistic axion field. This axion field will travel through an opaque wall into a second static magnetic field region where it turns partly back into an electromagnetic wave field with the same frequency as the laser. The ALPS collaboration is working towards a large scale LSW experiment at DESY in Hamburg, Germany. I will report on the status of the ALPS experiment. This work is supported by the Deutsche Forschungsgemeinschaft, PRISMA, the Helmholtz Association, the National Science Foundation and the Heising-Simons Foundation.

  4. Interleukin-10 and posttransplant lymphoproliferative disorder after kidney transplantation

    DEFF Research Database (Denmark)

    Birkeland, S.A.; Bendtzen, K.; Moller, B.

    1999-01-01

    Background. Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of transplantation, which comprises a morphologically and clinically heterogeneous spectrum of B-lymphocyte diseases. Risk factors include primary or reactivated Epstein-Barr virus (EBV) infection...... to the development of PTLD in three kidney transplanted patients. The study now includes nine patients that could be followed before and/or after the occurrence of lymphoma, Methods. Nine patients with lymphomas (eight PTLDs and one Hodgkin's disease) were diagnosed among 268 consecutive renal transplantations (1990...

  5. Post-kidney transplant large bowel lymphoproliferative disorder

    Directory of Open Access Journals (Sweden)

    Neeraj Singh

    2014-01-01

    Full Text Available Epstein-Barr virus (EBV-associated post-transplant lymphoproliferative disorder (PTLD is a serious complication of organ transplantation. The gastrointestinal (GI tract is a common site involved, but non-specific signs and symptoms often delay the diagnosis. We report a case of EBV-associated GI-PTLD in a 68-year-old kidney transplant patient who received the kidney ten months earlier. He presented with chronic diarrhea and developed massive pneumo-peritoneum secondary to multiple colonic perforations.

  6. Lack of correlation between immunologic markers and cell surface ultrastructure in the leukemic phase of lymphoproliferative diseases

    Energy Technology Data Exchange (ETDEWEB)

    Golomb, Harvey M.; Simon, Deberah

    1977-01-01

    In a prospective study of malignant cells from 13 patients with the leukemic phase of lymphoproliferative diseases, we wished to determine whether any correlation between the immunologic markers and the cell surface ultrastructure. Five patients had chronic lymphocytic leukemia, four had malignant lymphomas, poorly differentiated lymphocytic type, two had the Sezary syndrome, and one each had acute prolymphocytic leukemia and acute lymphocytic leukemia. Cell separation and isolation was done at room temperature for all specimens. Immunologic markers tested for were surface immunoglobins, a B-cell property, and E-rosettes, a T-cell property. Three patients had T-cell diseases, 6 had B-cell diseases, and 4 were classified as ''null.'' All but one patient had moderate to large numbers of microvilli on their malignant cells. The single exception had a typical B-cell form of chronic lymphocytic leukemia. There appears to be no correlation between immunologic markers and cell surface ultrastructure; therefore, SEM appears not to be valuable in the diagnosis or classification of immunologic sub-types of certain lymphoproliferative diseases.

  7. Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing.

    Science.gov (United States)

    Ono, Shintaro; Nakayama, Manabu; Kanegane, Hirokazu; Hoshino, Akihiro; Shimodera, Saeko; Shibata, Hirofumi; Fujino, Hisanori; Fujino, Takahiro; Yunomae, Yuta; Okano, Tsubasa; Yamashita, Motoi; Yasumi, Takahiro; Izawa, Kazushi; Takagi, Masatoshi; Imai, Kohsuke; Zhang, Kejian; Marsh, Rebecca; Picard, Capucine; Latour, Sylvain; Ohara, Osamu; Morio, Tomohiro

    2018-05-18

    Epstein-Barr virus (EBV) is associated with several life-threatening diseases, such as lymphoproliferative disease (LPD), particularly in immunocompromised hosts. Some categories of primary immunodeficiency diseases (PIDs) including X-linked lymphoproliferative syndrome (XLP), are characterized by susceptibility and vulnerability to EBV infection. The number of genetically defined PIDs is rapidly increasing, and clinical genetic testing plays an important role in establishing a definitive diagnosis. Whole-exome sequencing is performed for diagnosing rare genetic diseases, but is both expensive and time-consuming. Low-cost, high-throughput gene analysis systems are thus necessary. We developed a comprehensive molecular diagnostic method using a two-step tailed polymerase chain reaction (PCR) and a next-generation sequencing (NGS) platform to detect mutations in 23 candidate genes responsible for XLP or XLP-like diseases. Samples from 19 patients suspected of having EBV-associated LPD were used in this comprehensive molecular diagnosis. Causative gene mutations (involving PRF1 and SH2D1A) were detected in two of the 19 patients studied. This comprehensive diagnosis method effectively detected mutations in all coding exons of 23 genes with sufficient read numbers for each amplicon. This comprehensive molecular diagnostic method using PCR and NGS provides a rapid, accurate, low-cost diagnosis for patients with XLP or XLP-like diseases.

  8. Status of the ALPS experiment

    International Nuclear Information System (INIS)

    Ehret, Klaus

    2008-01-01

    The ALPS experiment at DESY searches for light particles which are coupling very weakly to photons. Primary physics goal is the search for axion like particles in a photon regeneration experiment. Central part of the experimental setup is a five Tesla strong superconducting HERA dipole magnet. During two operation periods in the years 2007 and 2008 we have collected first data and explored the sensitivity of the setup. A Fabry Perot laser cavity is being set up in order to increase the sensitivity by more than one order of magnitude. (orig.)

  9. A 5-year old male with “leukemic form” of disseminated post-transplant lymphoproliferative disorder

    Directory of Open Access Journals (Sweden)

    Saadiya Haque

    2010-03-01

    Full Text Available Post-transplant lymphoproliferative disorder (PTLD represents an abnormal lymphoid proliferation that occurs in recipients of solid organ or bone marrow allograft. It includes a diverse group of diseases ranging from polymorphic B-cell hyperplasia to frank malignant lymphoma. Clinical presentation is variable, ranging from asymptomatic to generalized lymphadenopathy, mononucleosis-like syndrome, nodal or extranodal tumors (usually gastrointestinal tract, systemic lymphomatous involvement, and rare (less than 1% of cases fulminant disseminated disease. PTLD is more common in children than in adults. Younger patients usually present with mononucleosis-like symptoms. We present an unusual case of a 5-year old male who developed a widely disseminated leukemic form of PTLD, involving lymph nodes, tonsils, multiple organs, bone marrow, cerebrospinal fluid, and peripheral blood.

  10. A typical aspects of intrathoracic posttransplantation lymphoproliferative disorders

    International Nuclear Information System (INIS)

    Beigelman, C.; Leblond, V.; Suberbielle, C.; Lenoir, S.; Dorent, R.; Grenier, P.

    1995-01-01

    Posttransplant lymphoproliferative disorders (PTLD), developing after immunosuppressive therapy in human organ-graft recipients, are, for the most part, Epstein-Barr virus-induced. The earlier the diagnosis is made, the greater the potential for reversibility. The chest radiographs and CT scans of 10 patients with thoracic locations of PTLD were reviewed. Mediastinal and hilar adenopathy, pulmonary nodules, and pleural thickening or effusion were encountered. The incidence of partial resolution with clinical remission appears to be noteworthy, and in all likelihood is related to the extensive necrosis that is frequently seen. Slow regression, transitory deterioration in one case, and localization only on the graft side in two cases, were observed. These morphological and evolutionary peculiarities must be known in order to optimize the diagnosis, and thus the prognosis, of these very original disorders. (orig.)

  11. Relative adrenal insufficiency in post-transplant lymphoproliferative disorder.

    Directory of Open Access Journals (Sweden)

    Cinclair R

    2003-01-01

    Full Text Available Post-transplant lymphoproliferative disorder is treated with rapid decrement of immunosuppressive therapy. This cannot be achieved with ease in patients on long-term glucocorticoid therapy, as chronically suppressed adrenal glands may not be capable of mounting adequate response to stress. A 52-year-old Caucasian male presented with fever, orthostatic hypotension, lymphadenopathy and hyponatraemia. Serum cortisol levels were within normal levels with a sub optimal response to stimulation by ACTH. Hyponatraemia and orthostasis responded poorly to fluid restriction, saline and salt repletion but corrected after increasing the steroid dose. The normal baseline cortisol levels represented a stimulated adrenal gland, however, the ACTH stimulation had inadequate response. This sub optimal stimulation and a good response to increased steroids suggest the presence of relative or occult adrenal insufficiency. Relative adrenal insufficiency must be considered in patients who have received prolonged glucocorticoid therapy and have symptoms such as hypotension and/or hyponatraemia.

  12. HLA antigens and post renal transplant lymphoproliferative disease : HLA-B matching is critical

    NARCIS (Netherlands)

    Bakker, N.A.; van Imhoff, G.W.; Verschuuren, E.A.M.; van Son, W.J.; van der Heide, J.J.H.; Lems, S.P.M.; Veeger, N.J.G.M.; Kluin, P.M.; Kluin-Nelemans, Hanneke; Hepkema, B.G.

    2005-01-01

    Although several risk factors for posttransplant lymphoproliferative disease (PTLD) after solid organ transplantation have been identified, the immunosuppressive regimen probably as most important one, their exact pathogenic role and relevance is still unclear. In hematopoietic stem cell

  13. Notch signalling in primary cutaneous CD30+ lymphoproliferative disorders: a new therapeutic approach?

    DEFF Research Database (Denmark)

    Kamstrup, M R; Biskup, E; Gniadecki, R

    2010-01-01

    The oncogenic potential of deregulated Notch signalling has been described in several haematopoietic malignancies. We have previously reported an increased expression of Notch1 in primary cutaneous CD30+ lymphoproliferative disorders, lymphomatoid papulosis and primary cutaneous anaplastic large...

  14. The epic of Hannibal through the Alps

    Directory of Open Access Journals (Sweden)

    Arbia Hilali

    2018-02-01

    Full Text Available A true myth is built around the figure of Hannibal and his journey to Rome through the Alps. After leaving the South of the Iberian Peninsula to his brother Hasdrubal, Hannibal leaves Cartagena, crosses the Pyrenees, goes up the valleys of the Rhone and Isere, crosses the Alps and ends in Italy in November 218 BC. Its stratagems are still authoritative, not to mention the exotic image of fighting elephants that have deeply marked the spirits. The crossing of the Alps has nourished art and ancient and modern literature. In contemporary Tunisia, antiquity finds a fundamental place and Hannibal redux is a national hero.

  15. Cerebral Post-Transplant Lymphoproliferative Disorder Occurring after Renal Transplantation: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Jang Ho; Byun, Woo Mok; Kim, Hong Chul; Hwang, Min Su [Dept. of Radiology, Yeungnam University College of Medicine, Daegu (Korea, Republic of)

    2012-04-15

    Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation and immunosuppression. A 36-year-old woman with a history of renal transplantation visited the hospital complaining of headache and on pathology was diagnosed with cerebral PTLD manifesting as multiple rim enhanced masses in both hemispheres. We report here a case of post-transplant lymphoproliferative disorder involving the cerebrum occurring after renal transplantation, and describe the MRI findings for this patient

  16. Cerebral Post-Transplant Lymphoproliferative Disorder Occurring after Renal Transplantation: A Case Report

    International Nuclear Information System (INIS)

    Suh, Jang Ho; Byun, Woo Mok; Kim, Hong Chul; Hwang, Min Su

    2012-01-01

    Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation and immunosuppression. A 36-year-old woman with a history of renal transplantation visited the hospital complaining of headache and on pathology was diagnosed with cerebral PTLD manifesting as multiple rim enhanced masses in both hemispheres. We report here a case of post-transplant lymphoproliferative disorder involving the cerebrum occurring after renal transplantation, and describe the MRI findings for this patient

  17. Systematic Epstein-Barr virus-positive T-cell lymphoproliferative disease presenting as a persistent fever and cough: a case report.

    Science.gov (United States)

    Ameli, Fereshteh; Ghafourian, Firouzeh; Masir, Noraidah

    2014-08-27

    Systemic Epstein-Barr virus-positive T-cell lymphoproliferative childhood disease is an extremely rare disorder and classically arises following primary acute or chronic active Epstein-Barr virus infection. It is characterized by clonal proliferation of Epstein-Barr virus-infected T-cells with an activated cytotoxic phenotype. This disease has a rapid clinical course and is more frequent in Asia and South America, with relatively few cases being reported in Western countries. The clinical and pathological features of the disease overlap with other conditions including infectious mononucleosis, chronic active Epstein-Barr virus infection, hemophagocytic lymphohistiocytosis and natural killer cell malignancies. We describe the rare case of systemic Epstein-Barr virus-positive T-cell lymphoproliferative childhood disease in a 16-year-old Malay boy. He presented with a six-month history of fever and cough, with pulmonary and mediastinal lymphadenopathy and severe pancytopenia. Medium- to large-sized, CD8+ and Epstein-Barr virus-encoded RNA-positive atypical lymphoid cells were present in the bone marrow aspirate. He subsequently developed fatal virus-associated hemophagocytic syndrome and died due to sepsis and multiorgan failure. Although systemic Epstein-Barr virus-positive T-cell lymphoproliferative childhood disease is a disorder which is rarely encountered in clinical practice, our case report underlines the importance of a comprehensive diagnostic approach in the management of this disease. A high level of awareness of the disease throughout the diagnosis process for young patients who present with systemic illness and hemophagocytic syndrome may be of great help for the clinical diagnosis of this disease.

  18. Age and prematurity of the Alps

    Science.gov (United States)

    Hergarten, Stefan; Stüwe, Kurt; Wagner, Thomas

    2010-05-01

    Although the Alps are among the best studied mountain ranges on Earth, the age of their topography is almost unknown. Even their relative stage of evolution is unclear: Are the Alps still growing, in a steady state or even decaying? Using the mean slope at given catchment size as a new geomorphic parameter we analyse the topography of the Alps. Our analysis provides one of the first quantitative constraints that shows that the range is still in its infancy: In contrast to several other mountain ranges, the Alps have still more than half of their evolution to a geomorphic steady state to go. Combining our results with sediment data from the surrounding accumulation spaces we infer that the formation of substantial topography began only 5-6 million years ago. Our results challenge a general consensus that the topographic evolution is distributed over much of the Miocene.

  19. Animal in vivo models of EBV-associated lymphoproliferative diseases: special references to rabbit models.

    Science.gov (United States)

    Hayashi, K; Teramoto, N; Akagi, T

    2002-10-01

    Animal models of human EBV-associated diseases are essential to elucidate the pathogenesis of EBV-associated diseases. Here we review those previous models using EBV or EBV-like herpesviruses and describe the details on our two newly-developed rabbit models of lymphoproliferative diseases (LPD) induced by simian EBV-like viruses. The first is Cynomolgus-EBV-induced T-cell lymphomas in rabbits inoculated intravenously (77-90%) and orally (82-89%) during 2-5 months. EBV-DNA was detected in peripheral blood by PCR from 2 days after oral inoculation, while anti-EBV-VCA IgG was raised 3 weeks later. Rabbit lymphomas and their cell lines contained EBV-DNA and expressed EBV-encoded RNA-1 (EBER-1). Rabbit lymphoma cell lines, most of which have specific chromosomal abnormality, showed tumorigenicity in nude mice. The second is the first animal model for EBV-infected T-cell LPD with virus-associated hemophagocytic syndrome (VAHS), using rabbits infected with an EBV-like herpesvirus, Herpesvirus papio (HVP). Rabbits inoculated intravenously with HVP-producing cells showed increased anti-EBV-VCA-IgG titers, and most (85%) subsequently died of fatal LPD and VAHS, with bleeding and hepatosplenomegaly, during 22-105 days. Peroral spray of cell-free HVP induced viral infection with seroconversion in 3 out of 5 rabbits, with 2 of the 3 infected rabbits dying of LPD with VAHS. Atypical T lymphocytes containing HVP-DNA and expressing EBER-1 were observed in many organs. Hemophagocytic histiocytosis was observed in the lymph nodes, spleen, bone marrow, and thymus. These rabbit models are also useful and inexpensive alternative experimental model systems for studying the biology and pathogenesis of EBV, and prophylactic and therapeutic regimens.

  20. Diagnosis, progression and intervention in Sjogren's syndrome

    NARCIS (Netherlands)

    Pijpe, Justin

    2006-01-01

    Sjögren’s syndrome (SS) is a chronic inflammatory and lymphoproliferative progressive autoimmune disease. It is characterized by B cell activation and infiltration of T and B cells in the exocrine glands. Common symptoms are related to diminished lacrimal and salivary gland function. Besides

  1. EXPRESSION OF A NEW A3 ANTIGEN IN THE CELLS OF PATIENTS WITH VARIOUS LYMPHOPROLIFERATIVE DISEASES

    Directory of Open Access Journals (Sweden)

    N. L. Deineko

    2014-01-01

    Full Text Available We have conducted a study of a novel monoclonal A3 antibody raised by means of hybridoma biotechnology. The study was performed with malignant cells of the patients with various lymphoproliferative disorders, and persons with nonmalignant diseases, as compared with intact lymphocytes from healthy people,using a method of immunocytochemical staining and indirect immunofluorescence technique. It was found that in cases of lymphoproliferative diseases with low proliferation rates, as based on the numbers of Ki-67 positive cells, as well as in non-malignant blood diseases, the A3 antigen was localized in nucleoli, and it was visualized as focal fluorescence. In malignant lymphoproliferative diseases with high proliferation indexes, the number of brightly fluorescent foci is observed, with formation of necklace-like structures within the nucleolar structures. The obtained data point to a diagnostic significance of A3 Mab in assessment of cellular proliferative rates in patients with various lymphoproliferative diseases. It was established that, in contrast to Ki-67, the proliferation stage could be determined for each cell, according to the number of fuorescent foci in nucleoli. This specific property of the A3 antigen points to its significance for diagnostics and malignancy staging of lymphoproliferative disorders.

  2. Semaine alpine 2008 : innover (dans) les Alpes

    OpenAIRE

    Bourdeau, Philippe; Bourdeau, Philippe; Corneloup, Jean; Corneloup, Jean; Finger-Stich, Andréa; Finger-Stich, Andréa; Giraut, Frédéric; Giraut, Frédéric; Kohler, Yann; Kohler, Yann; Macchiavelli, Andrea; Macchiavelli, Andrea; Scheurer, Thomas; Scheurer, Thomas; Ullrich, Aurelia

    2009-01-01

    Ce premier dossier en ligne se penche sur une question de grande actualité : l’innovation, pour interroger les conceptions et mises en œuvre de démarches innovantes dans les contextes montagnards. Ces textes sont issus de la « Semaine alpine », qui s’est déroulée en juin 2008 à l’Argentière-La Bessée, dans les Hautes-Alpes (France). Ces « Semaines alpines », en alternance avec les « Forums alpins », rassemblent tous les deux ans des chercheurs et des acteurs locaux de l’ensemble de l’arc alp...

  3. Pulmonary lymphoproliferative disorders with affinity to lymphoma: a clinicopathoradiologic study of 16 cases

    International Nuclear Information System (INIS)

    Fernandez Cruz, J.; Gonzalez Garcia, A.; Escobar Casas, P.; Gomez Benitez, S.; Gonzalez Guirao, M.A.; Borderas, F.

    1993-01-01

    Pulmonary lymphoproliferative disorders include plasma cell granuloma, Castleman's disease, pseudolymphoma, lymphocytic interstitial pneumonia, angioimmunoblastic lymphadenopathy and lymphomatoid granulomatosis. We carried out a retrospective study for the purpose of analysing the clinical and radiological findings of 16 cases of pulmonary lymphoproliferative disorders seen during the decade 1980-1990. The cases comprised 8 lymphocytic interstitial pneumonia, 5 lymphomatoid granulomatosis, 2 plasma cell granuloma and 1 angioimmunoblastic lymphadenopathy. Owing to the overlap and low specificity of the radiological patterns in these processes, histopathological examination is required. In view of the frequent evolution of pulmonary lymphoproliferative disorders to malignant lymphoma (4 cases, 1 of lymphocytic interstitial pneumonia and 3 of lymphomatoid granulomatosis, in our series) we provide a description of the radiological changes that occur during this process. (orig.)

  4. CERN: LEP in the Alps

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Full text: In January, when CERN's LEP electron-positron collider is enjoying a well-earned break, it has now become traditional for the hard pressed LEP team to have no respite. Instead they pack their bags and depart for Chamonix in the nearby French Alps to review the past year's experience and plan for the future. In the cold January 1993 light of Chamonix, 1992 (January/February, page 4) was deemed to have been a good year for LEP operations, with the switch to 90° betatron phase operation having paid off. The 65% improvement in integrated luminosity over 1991 was attributed to longer beam lifetimes, faster filling and improved overall efficiency. The commissioning of the eight-bunch 'pretzel' scheme was facilitated with the new optics, and break-even quickly achieved, so that physics could benefit from more bunches in the machine. During 1992, the injection chain was fully tested with eight bunches, and when this comes into routine operation this year, the pretzel scheme will benefit. Pretzel running also opens the possibility of still higher luminosity, up to 2x10 31 per sq cm per s, doubling the present level. However the finishing touches to high luminosity running are still more an art ('haute cuisine') than a science. Continuing studies of the inter correlation of different LEP conditions will help make this more systematic. The main factors affecting performance at 45 GeV are transverse mode coupling instabilities. The present working point gives good results, but there are still potentially interesting regions which need to be checked out. Beam lifetime and background are both limited by beam size and aperture. Background was reduced by improved focusing, while beam size is dominated by beam-beam effects. 90° operation proved its worth in 1992, but the inability to produce polarized beams was a disappointment, and a combined 90°/60° horizontal/vertical combination looked like offering the best of both worlds. Although

  5. Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children

    Energy Technology Data Exchange (ETDEWEB)

    Fletcher, B.D. [Department of Diagnostic Imaging, St. Jude Children`s Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105 (United States)]|[Departments of Radiology and Pediatrics, University of Tennessee, Memphis, Tennessee (United States); Heslop, H.E. [Department of Hematology/Oncology, St. Jude Children`s Research Hospital, Department of Pediatrics, University of Tennessee, Memphis, Tennessee (United States); Kaste, S.C. [Department of Diagnostic Imaging, St. Jude Children`s Research Hospital, Department of Radiology, University of Tennessee, Memphis, Tennessee (United States); Bodner, S. [Department of Pathology, St. Jude Children`s Research Hospital, Department of Pathology, University of Tennessee, Memphis, Tennessee (United States)

    1998-07-01

    We report three patients who developed severe supraglottic airway obstruction due to Epstein-Barr virus lymphoproliferative disease following allogeneic bone marrow transplantation. In addition to enlarged pharyngeal lymphoid tissue seen in all three patients, two had supraglottic airway narrowing and two developed pulmonary lymphoproliferative disease. They were treated with unmanipulated T cells or EBV-specific cytotoxic T lymphocytes. Life-threatening upper airway obstruction is a radiologically detectable complication of allogeneic bone marrow transplantation in children. (orig.) With 3 figs., 1 tab., 12 refs.

  6. Urbanization and depopulation in the Alps.

    Science.gov (United States)

    Batzing, W; Perlik, M; Dekleva, M

    1996-11-01

    Demographic developments in the European Alpine region are analyzed over the period 1870-1990. The region is defined as including parts of Germany, France, Italy, Liechtenstein, Austria, Switzerland, and Slovenia. "Studies of growth, stagnation, decline, commune size, and altitude in almost 6,000 communes are presented on three colored maps.... It is apparent that two highly divergent processes are at work and, accordingly, statistical mean values reveal little of importance. Approximately one-half of Alpine Europe is undergoing general economic and demographic growth and has experienced significant increase in population since the end of the agricultural era. This development has taken place primarily in low-lying valleys and basins and in areas bordering the Alps that have good access to transport routes. Tourism is not as widespread as generally assumed and is usually characterized by a punctate pattern. Only in the western part of the Eastern Alps does tourism account for widespread population growth at higher altitudes; elsewhere the Alps have not been affected by modern development and the economy and population are declining, with some areas in danger of becoming completely abandoned. The results challenge the earlier concept of the Alps as a rural region, once populated by peasants, where tourism now plays a major role." (EXCERPT)

  7. An economics figure of merit in ALPS

    International Nuclear Information System (INIS)

    Shatilla, Y.A.

    2000-01-01

    One of the most pressing issues facing the deregulated nuclear electric power industry is its economic competitiveness when compared to other sources of electrical power. Traditionally, finding the optimum loading pattern (LP) that meets all the safety and operational objective functions and at the same time produces the most attractive economical solutions is an iterative process. This is because (a) LP search tools usually lack the capability to generate equilibrium solutions and (b) economics objective functions are hard to include in the search process. In this paper, the Westinghouse Advanced Loading Pattern Search code (ALPS) has been demonstrated to successfully find LPs that meet user-defined operational and safety as well as economics objectives. This has been made possible by the development of TULIP language that allows the integration of external procedures into the search process of the main program, ALPS. In the example given, an economic figure of merit (EFM) has been defined and included via TULIP script into the fuel management optimization problem of a three-loop Westinghouse core operating an 18-month cycle. The LPs found by ALPS exhibit a clear trend of meeting and, in some cases, exceeding the EFM objective function defined for the ALPS search process a priori

  8. 78 FR 29787 - ALPS ETF Trust, et al.;

    Science.gov (United States)

    2013-05-21

    ... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30519; 812-13884] ALPS ETF...(d)(1)(A) and (B) of the Act. APPLICANTS: ALPS ETF Trust (``Trust''), ALPS Advisors, Inc. (``Adviser... actively managed exchange-traded fund (``ETF''). \\1\\ All entities that currently intend to rely on the...

  9. Mucosal Healing and Risk of Lymphoproliferative Malignancy in Celiac Disease

    Science.gov (United States)

    Lebwohl, Benjamin; Granath, Fredrik; Ekbom, Anders; Smedby, Karin Ekström; Murray, Joseph A.; Neugut, Alfred I.; Green, Peter HR; Ludvigsson, Jonas F.

    2013-01-01

    Background Celiac disease (CD) is associated with an increased risk of lymphoproliferative malignancy (LPM). It is unknown whether this risk is affected by the results of the follow-up intestinal biopsy, performed to document mucosal healing. Objective To examine the association between mucosal healing in CD and later LPM. Design Population-based cohort study Setting We identified patients with CD from all of Sweden’s 28 pathology departments. Patients Individuals with CD who had a follow-up biopsy after initial diagnosis. Measurements We compared the risk of LPM to that of the general population using expected rates; and through Cox regression we compared the rate of LPM in those with persistent villous atrophy to those with mucosal healing. Results Among 7,625 patients with CD and a follow-up biopsy, persistent villous atrophy was present in 3,308 (43%). The overall risk of LPM was increased compared to the general population (Standardized incidence ratio, SIR 2.81; 95%CI 2.10–3.67), but this increase was greater among those with persistent villous atrophy (SIR 3.78; 95%CI 2.71–5.12) as compared to those with mucosal healing (SIR 1.50; 95%CI 0.77–2.62). Persistent villous atrophy compared to mucosal healing was associated with an increased risk of LPM (Hazard ratio, HR 2.26; 95%CI 1.18–4.34). We found an increased risk of T cell lymphoma (HR 3.51; 95%CI 0.75–16.34), but no excess risk of B cell lymphoma (HR 0.97; 95%CI 0.21–4.49). Limitation We had no data on dietary compliance. Conclusions The increased LPM risk in CD is associated with the results of the follow-up biopsy, with a higher risk among those with persistent villous atrophy. Follow-up biopsy may be a means to effectively stratify CD patients regarding subsequent LPM risk. Primary funding source the National Center for Advancing Translational Sciences, National Institutes of Health, The American Scandinavian Foundation, the Celiac Sprue Association, Örebro University Hospital, Karolinska

  10. Risk factors for Epstein-Barr virus-related post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation.

    Science.gov (United States)

    Uhlin, Michael; Wikell, Helena; Sundin, Mikael; Blennow, Ola; Maeurer, Markus; Ringden, Olle; Winiarski, Jacek; Ljungman, Per; Remberger, Mats; Mattsson, Jonas

    2014-02-01

    Allogeneic hematopoietic stem cell transplantation is a successful treatment for hematologic malignancies and a variety of genetic and metabolic disorders. In the period following stem cell transplantation, the immune-compromised milieu allows opportunistic pathogens to thrive. Epstein-Barr virus-associated post-transplant lymphoproliferative disease can be a life-threatening complication for transplanted patients because of suppressed T-cell-mediated immunity. We analyzed possible risk factors associated with post-transplant lymphoproliferative disease in a cohort of over 1,000 patients. The incidence of post-transplant lymphoproliferative disease was 4%. Significant risk factors identified by multivariate analysis were: human leukocyte antigen-mismatch (PEpstein-Barr virus mismatch recipient-/donor+ (Pdisease grade II to IV (P=0.006), pre-transplant splenectomy (P=0.008) and infusion of mesenchymal stromal cells (P=0.015). The risk of post-transplant lymphoproliferative disease has increased in more recent years, from less than 2% before 1998 to more than 6% after 2011. Additionally, we show that long-term survival of patients with post-transplant lymphoproliferative disease is poor despite initial successful treatment. The 3-year survival rate among the 40 patients with post-transplant lymphoproliferative disease was 20% as opposed to 62% among patients without post-transplant lymphoproliferative disease (Pdisease after transplantation in need of pre-emptive measures.

  11. [POEMS syndrome: role and value of interleukin-6].

    Science.gov (United States)

    Andrès, E; Courouau, F; Kaltenbach, G; Maloisel, F; Imler, M

    1996-01-01

    POEMS syndrome is a systemic disorder with peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. The association of POEMS syndrome with lympho-proliferative disorder is very commun. The pathogenesis remains poorly understood but implication of cytokines (interleukins 1 and 6) is suspected. We report a case of a classic POEMS syndrome (with polyneuropathy, hepatomegaly, diabetes melitus, hyperpigmentation, monoclonal IgG lambda, anasarca and solitary plasmocytoma), associated with high serum levels of interleukin 6.

  12. Prevalence and patterns of renal involvement in imaging of malignant lymphoproliferative diseases

    International Nuclear Information System (INIS)

    Bach, Andreas Gunter; Behrmann, Curd; Spielmann, Rolf Peter; Surov, Alexey; Holzhausen, Hans Jurgen; Katzer, Michaela; Arnold, Dirk

    2012-01-01

    Background: Renal involvement in patients with lymphoproliferative disease is an uncommon radiological finding. Purpose: To determine its prevalence and radiological appearances in a patient population. Material and Methods: All forms of lymphoproliferative disease (ICD: C81-C96) were considered. From January 2005 to January 2010, 668 consecutive patients with lymphoproliferative disease were identified with the help of the radiological database and patient records. Inclusion criteria were complete staging including appropriate CT scan and/or MRI. All stored images (initial staging and follow-up examinations) were reviewed. Results: Review of all stored images revealed renal infiltration in patients with non-Hodgkin lymphoma (11 of 364 = 3.0%; median age = 65 years, m:f = 6:5) but also multiple myeloma (2 of 162 = 1.2%; median age = 72 years; m:f = 1:1) and leukemia (5 of 101 4.9%; median age = 12 years; m:f = 2:3). There were no cases of renal infiltration in 41 patients with Hodgkin's disease. In total there were six patients with solitary lesions, five patients with diffuse renal enlargement, four patients with perirenal lesions, and two patients with direct invasion of the kidney. Conclusion: In leukemia the most common imaging pattern is diffuse enlargement. In the other subtypes of lymphoproliferative disease no specific correlation between typical CT patterns and subtype of lymphoproliferative disease can be found. The prevalence of renal involvement is in line with earlier studies. Contrary to earlier reports, multiple lesions were not found to be a common pattern

  13. Glacial isostatic uplift of the European Alps

    Science.gov (United States)

    Mey, Jürgen; Scherler, Dirk; Wickert, Andrew D.; Egholm, David L.; Tesauro, Magdala; Schildgen, Taylor F.; Strecker, Manfred R.

    2016-01-01

    Following the last glacial maximum (LGM), the demise of continental ice sheets induced crustal rebound in tectonically stable regions of North America and Scandinavia that is still ongoing. Unlike the ice sheets, the Alpine ice cap developed in an orogen where the measured uplift is potentially attributed to tectonic shortening, lithospheric delamination and unloading due to deglaciation and erosion. Here we show that ∼90% of the geodetically measured rock uplift in the Alps can be explained by the Earth’s viscoelastic response to LGM deglaciation. We modelled rock uplift by reconstructing the Alpine ice cap, while accounting for postglacial erosion, sediment deposition and spatial variations in lithospheric rigidity. Clusters of excessive uplift in the Rhône Valley and in the Eastern Alps delineate regions potentially affected by mantle processes, crustal heterogeneity and active tectonics. Our study shows that even small LGM ice caps can dominate present-day rock uplift in tectonically active regions. PMID:27830704

  14. Suppressed peripheral and placental blood lymphoproliferative responses in first pregnancies: relevance to malaria

    DEFF Research Database (Denmark)

    Rasheed, F N; Bulmer, J N; Dunn, D T

    1993-01-01

    protein derivative [PPD]) were examined in the peripheral and placental blood of 102 Gambian women at the time of delivery. The lymphoproliferative responses of placental cells were poor to all antigens compared with those of peripheral blood (Candida P PPD P ....003, and 190N P = 0.10). Reduced proliferative capacity of placental mononuclear cells may contribute to heavy parasite colonization of this organ. Proliferation to malarial and PPD but not Candida antigens was selectively suppressed in peripheral and placental blood of primiparae relative to multiparae (F32 P...... = 0.07, 190L P = 0.09, 190N P = 0.007, PPD P = 0.09). Autologous plasma contained factors that suppressed lymphoproliferative responses to the same series of antigens to which the primiparae responded poorly (F32 P PPD P = 0.03). Malarial antibody levels were...

  15. Risk of Hematopoietic and Lymphoproliferative Malignancies among U. S. Radiologic Technologists

    International Nuclear Information System (INIS)

    Linet, M. S.; Fredman, D. M.; Mohan, A.; Morin Doody, M.; Ron, E.; Mabuchi, K.; Alexander, B. B.; Sigurdson, A.; Matanoski, G.; Hauptmann, M.

    2004-01-01

    To evaluate risks of hematopoietic and lymphoproliferative malignancies among medical workers exposed to protracted low-to-moderate-dose radiation exposures, a follow-up investigation was conducted in a nation wide cohort of U. S. radiologic technologists. eligible for this study were 71.894 technologists (78% female) certified for at least 2 years during 1926-82, who had responded to a baseline mail questionnaire during 1983-89, were cancer-free except for non-melanoma skin cancer at completion of the questionnaire, and completed a second questionnaire during 1994-98 or died through August 1998. There were 241 technologists with hematopoietic or lymphoproliferative malignancies, including 41 with leukemia subtypes associated with radiation exposures (specifically acute myeloid, acute lymphoid and chronic myeloid leukemias, hereafter designated radiogenic leukemias), 23 with chronic lymphocytic leukemia, 28 with multiple myeloma, 118 with non-Hodgkin lymphoma, and 31 with Hodgkin lymphoma. Of the 241 hematopoietic or lymphoproliferative malignancies identified among radiologic technologists, 85 percent were confirmed by medical records or death certificates, including 98 percent of radiogenic leukemia. Risks of the hematopoietic or lymphoproliferative malignancies were evaluated in relation to questionnaire-derived information on employment as a radiologic technologist, including procedures, work practices, and protective measures. cox proportional hazards regression analysis was used to compute relative risks and 95% confidence intervals, using age at diagnosis as the response, stratifying at baseline for birth cohort in 5-year intervals, and adjusting for potential confounding. Risks were not increased for any of the hematopoietic or lymphoproliferative neoplasms according to year first worked or total duration of years worked as radiologic technologist. For the combined radiogenic leukemias, risks rose significantly with an increasing number of years worked

  16. Sustainable mobility in Slovenian Julian Alps

    Directory of Open Access Journals (Sweden)

    Matej Ogrin

    2012-12-01

    Full Text Available Some mountainous areas, especially tourist areas, are facing traffc loads that exceed the carrying capacity and bring problems to local residents, visitors, public services, etc. Traf-fc problems can also cause a decrease of popularity of the tourist site and a decrease of tourist income therefore, in some Alpine areas in Slovenia, measures have begun to be taken to decrease traffc loads, and to support measures of sustainable mobility. This article deals with such measures and plans that have been taken in the Julian Alps of Slovenia to decrease the negative traffc impacts of tourism mobility in the municipalities of Kranjska Gora, Bohinj and Bovec.

  17. Potential of hydroelectric power in the Alps

    International Nuclear Information System (INIS)

    Schleiss, A.

    2002-01-01

    This article presents in detail the current hydro power production, consumption and export in the six main countries using this alpine energy resource: France, Germany, Austria, Italy, Slovenia and Switzerland. For the time being, one quarter of the Alps' hydro energy resource is still unused. The article discusses the opportunity offered by the current European electricity market deregulation to extend alpine hydro power use. For each country, the expected increase in production capacity, including technical, geographical and economic aspects, is analysed and reported in several figures and tables

  18. Occurrence and prognostic relevance of CD30 expression in post-transplant lymphoproliferative disorders

    DEFF Research Database (Denmark)

    Vase, Maja Ølholm; Maksten, Eva Futtrup; Bendix, Knud

    2015-01-01

    Post-transplant lymphoproliferative disorders (PTLDs) are potentiallyfatal, often Epstein-Barr virus (EBV)-driven neoplasias developing in immunocompromised hosts. Initial treatment usually consists of a reduction in immunosuppressive therapy and/or rituximab with or without chemotherapy. However...... favorable outcome. For diffuse large B-cell lymphoma (DLBCL)-type PTLD this was regardless of EBV status, and remained significant in multivariate analysis. Cell-of-origin had no independent prognostic value in our series of DLBCL PTLD....

  19. Post-transplant Lymphoproliferative Disorder Arising from Renal Allograft Parenchyma: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Byung Kwan; Kim, Chan Kyo; Kwon, Ghee Young [Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul (Korea, Republic of)

    2010-06-15

    Post-transplant lymphoproliferative disorder (PTLD) is a rare but serious complication that occurs in patients undergoing kidney transplantation. PTLD usually manifests as a renal hilar mass comprised of histologically B-lymphocytes. We report our experience of managing a patient with PTLD arising from renal parenchyma. Ultrasonographic and MR imaging features of this unusual PTLD suggested differentiated renal cell carcinoma arising from the renal allograft

  20. Epstein-Barr virus induced hemophagocytic lymphohistiocytosis in X-linked lymphoproliferative disease

    Directory of Open Access Journals (Sweden)

    Senthilkumar Sankararaman

    2014-01-01

    Full Text Available X-linked lymphoproliferative disease (XLP is a rare, often fatal genetic disorder characterized by extreme vulnerability to Epstein-Barr virus (EBV. EBV-induced hemophagocytic lymphohistiocytosis (HLH is a known presentation in XLP. In EBV-induced HLH in XLP, the brain imaging findings in the acute phase include a non specific pattern. In this report, we highlight the magnetic resonance imaging and magnetic resonance spectroscopy findings in a child with EBV induced HLH in XLP.

  1. Patogenetic correction of anemia with erythropoiesis-stimulating agents in lymphoproliferative disorders (literature review

    Directory of Open Access Journals (Sweden)

    N. A. Romanenko

    2014-07-01

    Full Text Available Literature review of anemia pathogenesis in patients with lymphatic system malignancies is presented. Advantages and disadvanta ges of eritropoiesis-stimulating preparations (ESP used for anemia correction are shown. Efficacy of anemia treatment with ESP in various types of lymphoproliferative disorders (LPD is presented. Prognostic factors that predict positive response on ESP in LPD pati ents and reduce treatment cost are identified.

  2. Patogenetic correction of anemia with erythropoiesis-stimulating agents in lymphoproliferative disorders (literature review

    Directory of Open Access Journals (Sweden)

    N. A. Romanenko

    2011-01-01

    Full Text Available Literature review of anemia pathogenesis in patients with lymphatic system malignancies is presented. Advantages and disadvanta ges of eritropoiesis-stimulating preparations (ESP used for anemia correction are shown. Efficacy of anemia treatment with ESP in various types of lymphoproliferative disorders (LPD is presented. Prognostic factors that predict positive response on ESP in LPD pati ents and reduce treatment cost are identified.

  3. Underground waters in Kamnik and Savinja Alps

    Directory of Open Access Journals (Sweden)

    Dušan Novak

    1995-12-01

    Full Text Available Dye-tracing tests in the region of the alps Velika planina and Mala planina have shown that the major part of the region drains towards the spring of the Lučnica at Podvolovljek where is also a small fish farm. As to the water level, the marginal and central parts also drain into the stream Lučka Bela or the springs at Volovljek.Quite interesting is the high-mountain plateau Veža, a karstified territory surrounded by the valleys Robanov kot and Podvolovljek, as well as the tributary area of the stream Kamniška Bistrica. Here there is every indication of the deep runoff into the springs above Luče, the spring Pečovski izvir, the temporary springswhich are close to the stream Savinja and into the unknown springs in the gorge below the rocky needle Igla. With regard to the water level, the higher parts of the massif can drain towards the valleys Robanov kot, Podvolovljek and Kamniška Bistrica.The tributary area of the Bistrica is quite well known, too. It has been discovered that the area of the saddle Kamniško sedlo drains towards the springs of the Savinja. The territories of the saddle Kokrsko sedlo, the alps Dolge njive and Kalce drain into the spring Studenci below Mokrica.

  4. Sjogren′s Syndrome: A Review

    Directory of Open Access Journals (Sweden)

    Rani Somani

    2011-01-01

    Full Text Available Sjogren′s syndrome, also known as "Mikulicz disease" or "Sicca syndrome" is a systemic autoimmune disease in which immune cells attack and destroy the exocrine glands that produce tears and saliva. It can exist by itself (primary Sjogren syndrome or develop in association with another disorder such as rheumatoid arthritis, systemic sclerosis, primary biliary cirrhosis or Hashimoto thyroiditis (associated Sjogren syndrome. Hallmarks are the dry mouth and dry eyes known as the Sicca syndrome. Sjogren syndrome affects t million to 4 million people in the United States- Most are over 40 years old at the time of diagnosis. As there is no known cure for Sjogren syndrome, treatment focuses on relieving symptoms and preventing complications. The most serious complication associated with primary Sjogren syndrome is the development of a lymphoproliferative disease. primarily non-Hodgkin lymphoma.

  5. Cultures et politiques dans les Alpes contemporaines

    Directory of Open Access Journals (Sweden)

    Bernard Debarbieux

    2009-03-01

    Full Text Available Plus que jamais, l’espace alpin est marqué par le déploiement de flux toujours plus variés, toujours plus puissants, et symétriquement par la multiplication d’initiatives destinées à conforter ou à régénérer l’idée de localité. Quelles spatialités et quelles territorialités travaillent les populations alpines aujourd’hui ? Quelles sont les figures contemporaines de la circulation et des flux, et les figures complémentaires de l’ancrage et de la refondation territoriale ? Voici les questions que cet essai se propose de développer. Ce texte reprend le contenu d’une conférence donnée dans le cadre de la célébration du centenaire de l’Institut de Géographie Alpine. Cette conférence, comme les autres données à cette occasion, avait adopté une forme libre dressant un bilan et des perspectives de la situation alpine. La trace écrite adoptée ici prend alors logiquement la forme d’un essai.More than ever before, the Alps are affected by increasingly varied and powerful flows and equally by the multiplication of initiatives designed to strengthen or regenerate the idea of “locality” (place. What spatialities and what territorialities activate the populations of the Alps today? What are the contemporary figures relating to circulation and flows and the complementary figures concerning spatial “anchoring” or fixity and new territorial foundations? These are the questions that this essay, proposes to develop. This text takes another look at the subject of a lecture given as part of celebrations to mark the centenary of the Institut de Géographie Alpine. This lecture, like the others given on this occasion, adopted a free format, presenting a report on the current situation in the Alps and prospects for the future. The written format adopted here logically takes the form of an essay. Readers looking for detailed illustrations and references are referred to three scientific articles published by the same

  6. Galaxy Clusters as Tele-ALP-scopes

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Axion-like particles have good theoretical motivation and are characterized by conversion to photons in astrophysical magnetic fields. Galaxy clusters are the most efficient convertors of axion-like particles to photons in the universe. I discuss the physics and phenomenology of ALPs, and describe their astrophysical implications, with particular reference to the recently observed 3.5 keV X-ray line that is a candidate for a dark matter decay line. I discuss interpretations of this line in terms of dark matter decaying to an axion-like particle, that then converts to a photon in cluster magnetic fields, and describe the compatibility of this scenario with data and the different phenomenology for cool-core and non-cool-core clusters.

  7. CD30-Positive T-Cell Lymphoproliferative Disease of the Oral Mucosa in Children: A Manifestation of Epstein-Barr Virus-Associated T-Lymphoproliferative Disorder.

    Science.gov (United States)

    Hong, Mineui; Ko, Young Hyeh

    2015-11-01

    Eosinophilic ulcer of the oral mucosa (EUOM) is a very rare, benign, self-limiting ulcerative lesion of the oral cavity of unknown pathogenesis, and belongs to the same spectrum of CD30(+) T-cell lymphoproliferative disease (LPD) of the oral mucosa. The etiology and pathogenesis of the disease are unknown. We report two cases in children who were initially diagnosed with EUOM and CD30(+) T-cell LPD, respectively. However, retrospective analysis revealed that a majority of infiltrated atypical T cells were positive for Epstein-Barr virus (EBV). The present cases suggest that the pathogenesis and etiology of EUOM or CD30(+) T-cell LPD occurring in children are different from those in adults. EUOM or CD30(+) T-cell LPD in children is a manifestation of EBV-positive T-cell LPD, and should therefore be distinguished from the disease in adults.

  8. Tumor Microenvironment and Immune Effects of Antineoplastic Therapy in Lymphoproliferative Syndromes

    Science.gov (United States)

    Álvaro, Tomás; de la Cruz-Merino, Luis; Henao-Carrasco, Fernando; Villar Rodríguez, José Luis; Vicente Baz, David; Codes Manuel de Villena, Manuel; Provencio, Mariano

    2010-01-01

    Lymphomas represent a wide group of heterogenic diseases with different biological and clinical behavior. The underlying microenvironment-specific composition seems to play an essential role in this scenario, harboring the ability to develop successful immune responses or, on the contrary, leading to immune evasion and even promotion of tumor growth. Depending on surrounding lymphoid infiltrates, lymphomas may have different prognosis. Moreover, recent evidences have emerged that confer a significant impact of main lymphoma's treatment over microenvironment, with clinical consequences. In this review, we summarize these concepts from a pathological and clinical perspective. Also, the state of the art of lymphoma's anti-idiotype vaccine development is revised, highlighting the situations where this strategy has proven to be successful and eventual clues to obtain better results in the future. PMID:20814546

  9. Prevention of Human Lymphoproliferative Tumor Formation in Ovarian Cancer Patient-Derived Xenografts

    Directory of Open Access Journals (Sweden)

    Kristina A. Butler

    2017-08-01

    Full Text Available Interest in preclinical drug development for ovarian cancer has stimulated development of patient-derived xenograft (PDX or tumorgraft models. However, the unintended formation of human lymphoma in severe combined immunodeficiency (SCID mice from Epstein-Barr virus (EBV–infected human lymphocytes can be problematic. In this study, we have characterized ovarian cancer PDXs which developed human lymphomas and explore methods to suppress lymphoproliferative growth. Fresh human ovarian tumors from 568 patients were transplanted intraperitoneally in SCID mice. A subset of PDX models demonstrated atypical patterns of dissemination with mediastinal masses, hepatosplenomegaly, and CD45-positive lymphoblastic atypia without ovarian tumor engraftment. Expression of human CD20 but not CD3 supported a B-cell lineage, and EBV genomes were detected in all lymphoproliferative tumors. Immunophenotyping confirmed monoclonal gene rearrangements consistent with B-cell lymphoma, and global gene expression patterns correlated well with other human lymphomas. The ability of rituximab, an anti-CD20 antibody, to suppress human lymphoproliferation from a patient's ovarian tumor in SCID mice and prevent growth of an established lymphoma led to a practice change with a goal to reduce the incidence of lymphomas. A single dose of rituximab during the primary tumor heterotransplantation process reduced the incidence of CD45-positive cells in subsequent PDX lines from 86.3% (n = 117 without rituximab to 5.6% (n = 160 with rituximab, and the lymphoma rate declined from 11.1% to 1.88%. Taken together, investigators utilizing PDX models for research should routinely monitor for lymphoproliferative tumors and consider implementing methods to suppress their growth.

  10. The ALP miracle: unified inflaton and dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Daido, Ryuji; Takahashi, Fuminobu [Department of Physics, Tohoku University, Sendai, Miyagi 980-8578 (Japan); Yin, Wen, E-mail: daido@tuhep.phys.tohoku.ac.jp, E-mail: fumi@tuhep.phys.tohoku.ac.jp, E-mail: wyin@ihep.ac.cn [IHEP, Chinese Academy of Sciences, Beijing 100049 (China)

    2017-05-01

    We propose a scenario where both inflation and dark matter are described by a single axion-like particle (ALP) in a unified manner. In a class of the minimal axion hilltop inflation, the effective masses at the maximum and mimimum of the potential have equal magnitude but opposite sign, so that the ALP inflaton is light both during inflation and in the true vacuum. After inflation, most of the ALPs decay and evaporate into plasma through a coupling to photons, and the remaining ones become dark matter. We find that the observed CMB and matter power spectrum as well as the dark matter abundance point to an ALP of mass m {sub φ} = O(0.01) eV and the axion-photon coupling g {sub φ} {sub γ} {sub γ} = O(10{sup −11}) GeV{sup −1}: the ALP miracle . The suggested parameter region is within the reach of the next generation axion helioscope, IAXO, and high-intensity laser experiments in the future. Furthermore, thermalized ALPs contribute to hot dark matter and its abundance is given in terms of the effective number of extra neutrino species, Δ N {sub eff} ≅ 0.03, which can be tested by the future CMB and BAO observations. We also discuss a case with multiple ALPs, where the coupling to photons can be enhanced in the early Universe by an order of magnitude or more, which enlarges the parameter space for the ALP miracle. The heavy ALP plays a role of the waterfall field in hybrid inflation, and reheats the Universe, and it can be searched for in various experiments such as SHiP.

  11. The ALP miracle: unified inflaton and dark matter

    International Nuclear Information System (INIS)

    Daido, Ryuji; Takahashi, Fuminobu; Yin, Wen

    2017-01-01

    We propose a scenario where both inflation and dark matter are described by a single axion-like particle (ALP) in a unified manner. In a class of the minimal axion hilltop inflation, the effective masses at the maximum and mimimum of the potential have equal magnitude but opposite sign, so that the ALP inflaton is light both during inflation and in the true vacuum. After inflation, most of the ALPs decay and evaporate into plasma through a coupling to photons, and the remaining ones become dark matter. We find that the observed CMB and matter power spectrum as well as the dark matter abundance point to an ALP of mass m φ = O(0.01) eV and the axion-photon coupling g φ γ γ = O(10 −11 ) GeV −1 : the ALP miracle . The suggested parameter region is within the reach of the next generation axion helioscope, IAXO, and high-intensity laser experiments in the future. Furthermore, thermalized ALPs contribute to hot dark matter and its abundance is given in terms of the effective number of extra neutrino species, Δ N eff ≅ 0.03, which can be tested by the future CMB and BAO observations. We also discuss a case with multiple ALPs, where the coupling to photons can be enhanced in the early Universe by an order of magnitude or more, which enlarges the parameter space for the ALP miracle. The heavy ALP plays a role of the waterfall field in hybrid inflation, and reheats the Universe, and it can be searched for in various experiments such as SHiP.

  12. Long-term follow-up of kidney transplant patients with posttransplant lymphoproliferative disorder

    DEFF Research Database (Denmark)

    Birkeland, S A; Hamilton-Dutoit, Stephen Jacques; Bendtzen, K

    2003-01-01

    Posttransplant lymphoproliferative disorder (PTLD) can be resolved in many transplant patients by the reduction or cessation of immunosuppression, after which many grafts continue to function as the result of a form of operational tolerance. When graft function deteriorates, retransplantation may...... be an option. Cytokines such as interleukin (IL)-10 and IL-18 may play a role in PTLD tolerance induction and tumor regression. We report long-term follow-up on the duration of graft tolerance and the course of retransplantation in a series of patients who underwent kidney transplantation and demonstrated PTLD...

  13. The splenomegaly of myeloproliferative and lymphoproliferative disorders: splenic cellularity and vascularity

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, B (Capital Hospital, Peking University Medical College, Beijing (China)); Lewis, S.M. (Department of Haematology, Royal Postgraduate Medical School, London (UK))

    1989-01-01

    Employing radionuclide scanning, the volume of the spleen, its red cell pool and plasma pool have been measured in vivo, and the relative proportions of cellularity and vascularity of the spleen have been calcualted in 51 patients with myeloproliferactive and lymphoproliferative disorders. In primary proliferative polycythaemia (polycythaemia vera), the increase of spleen size was attributed mainly to the increase of splenic vascularity; in myelofibrosis and in hairy cell leukaemia, the increase of spleen size was associated with increase in both splenic vascularity and cellularity, whilst in size was associated with increase in both splenic vascularity and cellularity, whilst in CGL and CLL the increase was attributed more to cellularity than to vascularity. (author).

  14. Treatment of Primary Cutaneous CD4 Small/Medium T cell Lymphoproliferative Disorder with Intralesional Triamcinolone Acetonide.

    Science.gov (United States)

    2018-02-15

    12. REPORT TYPE 02/15/2018 Poster 4. TITLE AND SUBTITLE Treatment of Primary Cutaneous CD4+ Small/Medium T- cell Lymphoproliferative Disorder with...cutaneous CD4+ small/medium T- cell lymphoproliferative disorder (LPD) is a generally indolent cutaneous T- cell proliferation. Most cases follow a benign...lmmunohistochemistry showed diffuse CD3+ CD4+ T- cells without CD30, TIA1 or CD10. A subset of medium to large cells expressed BCL-6. Small subsets of B- cells and CDB

  15. Western Italian Alps Monthly Snowfall and Snow Cover Duration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of snow observations for 18 stations in the western Italian Alps. Two types of data are included: monthly snowfall amounts and monthly snow...

  16. MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome

    Directory of Open Access Journals (Sweden)

    Xixi Zhang

    2016-09-01

    Full Text Available MLKL, a key component downstream of RIPK3, is suggested to be a terminal executor of necroptosis. Genetic studies have revealed that Ripk3 ablation rescues embryonic lethality in Fadd- or Caspase-8-deficient mice. Given that RIPK3 has also been implicated in non-necroptotic pathways including apoptosis and inflammatory signaling, it remains unclear whether the lethality in Fadd−/− mice is indeed caused by necropotosis. Here, we show that genetic deletion of Mlkl rescues the developmental defect in Fadd-deficient mice and that Fadd−/−Mlkl−/− mice are viable and fertile. Mlkl−/−Fadd−/− mice display significantly accelerated lymphoproliferative disease characterized by lymphadenopathy and splenomegaly when compared to Ripk3−/− Fadd−/− mice. Mlkl−/−Fadd−/− bone-marrow-derived macrophages and dendritic cells have impaired NLRP3 inflammasome activation associated with defects in ASC speck formation and NF-κB-dependent NLRP3 transcription. Our findings reveal that MLKL and FADD play critical roles in preventing lymphoproliferative disease and activating the NLRP3 inflammasome.

  17. Bone Marrow and Peripheral Blood Leptin Levels in Lymphoproliferative Diseases - Relation to the Bone Marrow Fat and Infiltration

    Czech Academy of Sciences Publication Activity Database

    Gaja, A.; Churý, Z.; Pecen, Ladislav; Fraňková, H.; Jandáková, H.; Hejlová, N.

    2000-01-01

    Roč. 47, č. 5 (2000), s. 307-312 ISSN 0028-2685 Institutional research plan: AV0Z1030915 Keywords : leptin * bone marrow fat * bone marrow infiltration * lymphoproliferative disease Subject RIV: BA - General Mathematics Impact factor: 0.579, year: 2000

  18. Development of an Epstein-Barr virus-associated lymphoproliferative disorder in a patient treated with azacitidine for chronic myelomonocytic leukaemia.

    Science.gov (United States)

    Menter, T; Schlageter, M; Bastian, L; Haberthür, R; Rätz Bravo, A E; Tzankov, A

    2014-03-01

    Some chemotherapeutic agents can cause iatrogenic lymphoproliferative disorders. In analogy to what has been observed with other nucleoside analogues such as cladribine and fludarabine, we document the first case of an Epstein-Barr virus-positive, iatrogenic immunodeficiency-associated, lymphoproliferative disease, formally resembling polymorphic post-transplant lymphoproliferative disease in a patient treated with azacitidine (Vidaza) for chronic myelomonocytic leukaemia (CMML). A 78-year-old female patient was diagnosed with CMML in January 2012, and treatment with azacitidine was initiated, which lasted for five cycles from February until June 2012. The patient was hospitalized in June 2012 under the suspicion of pneumonia. Transformation of the CMML was suspected at that time too. During hospitalization, a generalized enlargement of the lymph nodes and the spleen was noticed. The patient rapidly deteriorated and finally died of respiratory insufficiency. At autopsy, an Epstein-Barr virus-associated lymphoproliferative disorder, resembling polymorphic post-transplant lymphoproliferative disease with involvement of the lymph nodes, the spleen and the lung and causing necrotizing pneumonia, was diagnosed. Diagnostic criteria for diffuse large B-cell lymphoma or infectious mononucleosis-like lymphoproliferative disease were not met. This is the first documented case of an azacitidine-associated lymphoproliferative disease, raising awareness for possible not yet known side effects of this drug, which should be kept in mind by oncologists and pathologists. Copyright © 2013 John Wiley & Sons, Ltd.

  19. Post-Transplant Lymphoproliferative Disorder (PTLD) Manifesting in the Oral Cavity of a 13-Year-Old Liver Transplant Recipient (LTx).

    Science.gov (United States)

    Krasuska-Sławińska, Ewa; Minko-Chojnowska, Izabela; Pawłowska, Joanna; Dembowska-Bagińska, Bożenna; Pronicki, Maciej; Olczak-Kowalczyk, Dorota

    2015-08-18

    BACKGROUND Post-transplant lymphoproliferative disorder (PTLD) is a potential complication of solid organ or bone marrow transplants. The main PTLD risk factors are: the Epstein-Barr virus (EBV), transplant type, and use of immunosuppressants. It mainly consists of an uncontrolled growth of lymphocytes in transplant recipients under chronic immunosuppressive therapy. About 85% of PTLDs are EBV-containing B-cell proliferations; 14% are T-cell proliferations, of which only 40% contain EBV; and the remaining 1% is NK-cell or plasmocyte proliferations. PTLD may present various clinical manifestations, from non-specific mononucleosis-like syndrome to graft or other organ damage resulting from pathologic lymphocyte infiltration. PTLD may manifest in the oral cavity. CASE REPORT The objective of this study was to present the case of a 13-year-old female living-donor liver transplant recipient, resulting from biliary cirrhosis caused by congenital biliary atresia, with exophytic fibrous lesions on buccal mucosa and tongue. Exophytic and hyperplastic lesion of oral mucosa were removed and histopathological examination revealed polymorphic PTLD. The patient underwent 6 cycles of CHOP chemotherapy and all the oral lesions regressed completely. CONCLUSIONS All oral pathological lesions in organ transplant recipients need to be surgically removed and histopathologically examined because they present an increased risk of neoplastic transformations such as PTLD.

  20. A rare association of Castleman′s disease and nephrotic syndrome

    Directory of Open Access Journals (Sweden)

    I Tazi

    2011-01-01

    Full Text Available Castleman′s Disease (CD is an uncommon and poorly understood disorder of lymph node hyperplasia of unknown etiology. This entity belongs to the atypical lymphoproliferative disorders, a heterogeneous group of diseases characterized by a hyperplastic reactive process involving the immune system. The association of the nephrotic syndrome and CD is extremely rare and their interrelation remains enigmatic. We report a case of CD of the hyaline-vascular type with unicentric localization complicated by nephrotic syndrome.

  1. Crustal structure of the Eastern Alps and their foreland

    DEFF Research Database (Denmark)

    Grad, M.; Brückl, E.; Majdanski, M.

    2009-01-01

    The subject of this paper concerns the seismic modelling of the crustal structure in the transition zone from the Bohemian Massif, across the Molasse basin and the Eastern Alps to the Southern Alps, mainly on the territory of Austria. The CEL10/Alp04 profile crosses the triple point of the European......) are distinct up to 60-90 km offset and are characterized by large variations in apparent velocity and amplitude. The contact between the Molasse basin and the Eastern Alps represents a barrier for seismic waves. Mid-crustal reflections (Pc) are usually recorded at short distance intervals (20-50 km......, was undertaken using a ray-tracing technique. The P-wave velocity in the crystalline upper crust of the Bohemian Massif and Molasse basin is about 6.15 km s-1, which is slightly higher than in the Alpine area (about 6.0 km s-1). Below the northern accretionary wedge of the Eastern Alps low-velocity sediments...

  2. Status and distribution of the lynx in the German Alps

    Directory of Open Access Journals (Sweden)

    Petra Kaczensky

    1998-09-01

    Full Text Available Abstract The lynx (Lynx lynx had been eradicated in the German Alps by the middle of the 19th century. Since the early 1970s there have been several attempts to initiate the re-introduction of lynx into the German Alps, but none of the projects could be carried out because of the still very controversial attitudes towards the species, and because of competition between institutions. Natural re-colonization of the German Alps by lynx can be expected sooner or later from Switzerland or Austria. Although lynx are already present in some parts of Germany outside the Alps, neither an organized monitoring system nor compensation regulations for losses of livestock exist. For a successful comeback of lynx into Germany, including the German Alps, more efforts than a year-round protection by the federal hunting law is needed. Initiative management actions and intensive public education are necessary to obtain and secure public acceptance of the lynx.

  3. Age and Prematurity of the Alps Derived from Topography

    Science.gov (United States)

    Hergarten, S.; Wagner, T.; Stüwe, K.

    2010-09-01

    The European Alps are one of the best studied mountain ranges on Earth, but yet the age of their topography is almost unknown. Even their relative stage of evolution is unclear: Are the Alps still growing, in a steady state or already decaying, and is there a significant difference between Western and Eastern Alps? Using a new geomorphic parameter we analyze the topography of the Alps and provide one of the first quantitative constraints demonstrating that the range is still in its infancy: In contrast to several other mountain ranges, the Alps have still more than half of their evolution to a geomorphic steady state to go. Combining our results with sediment budget data from the surrounding basins we infer that the formation of the present topography began only 5-6 million years ago. Our results question the apparent consensus that the topographic evolution is distributed over much of the Miocene and might give new impulses to the reconstruction of paleoclimate in Central Europe.

  4. Searching for axions and ALPs from string theory

    Energy Technology Data Exchange (ETDEWEB)

    Ringwald, Andreas

    2012-09-15

    We review searches for closed string axions and axion-like particles (ALPs) in IIB string flux compactifications. For natural values of the background fluxes and TeV scale gravitino mass, the moduli stabilisation mechanism of the LARGE Volume Scenario predicts the existence of a QCD axion candidate with intermediate scale decay constant, f{sub a} {proportional_to}10{sup 9/12} GeV, associated with the small cycles wrapped by the branes hosting the visible sector, plus a nearly massless and nearly decoupled ALP associated with the LARGE cycle. In setups where the visible sector branes are wrapping more than the minimum number of two intersecting cycles, there are more ALPs which have approximately the same decay constant and coupling to the photon as the QCD axion candidate, but which are exponentially lighter. There are exciting phenomenological opportunities to search for these axions and ALPs in the near future. For f{sub a} {proportional_to}10{sup 11/12} GeV, the QCD axion can be the dominant part of dark matter and be detected in haloscopes exploiting microwave cavities. For f{sub a} {proportional_to}10{sup 9/10} GeV, the additional ALPs could explain astrophysical anomalies and be searched for in the upcoming generation of helioscopes and light-shining-through-a-wall experiments.

  5. Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative Disorders.

    Science.gov (United States)

    Yang, Xi; Nishida, Naonori; Zhao, Xiaodong; Kanegane, Hirokazu

    2015-10-01

    Epstein-Barr virus (EBV) was discovered 50 years ago from an african Burkitt lymphoma cell line. EBV-associated lymphoproliferative disorders (LPDs) are life- threatening diseases, especially in children. In this article, we review EBV-associated LPDs, especially in the area of primary immunodeficiency disease (PID). We searched PubMed for publications with key words including EBV infection, lymphoma, LPDs and PID, and selected the manuscripts written in English that we judged to be relevant to the topic of this review.On the basis of the data in the literature, we grouped the EBV-associated LPDs into four categories: nonmalignant disease, malignant disease, acquired immunodeficiency disease and PID. Each category has its own risk factor for LPD development. EBV-associated LPD is a complex disease, creating new challenges for diagnosis and treatment.

  6. Adult systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease: A case report.

    Science.gov (United States)

    Wang, Youping; Liu, Xinyue; Chen, Yan

    2015-09-01

    Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (EBV + T-LPD) occurs mainly in Asia and South America and is extremely rare in adults. The disease is characterized by a clonal proliferation of EBV-infected T cells with a cytotoxic immunophenotype and is associated with a poor clinical outcome and can be life-threatening. The majority of the patients have evidence of systemic disease, often with lymph node, liver and spleen involvement. The present study describes a case of adult systemic EBV + T-LPD with high fever, systemic lymphadenopathy, hepatosplenomegaly, nose-pharynx neoplasm, pancytopenia, EB virus infection and proliferative bone marrow, with the aim of improving the understanding of the condition.

  7. Endobronchial Epstein-Barr Virus Associated Post-transplant Lymphoproliferative Disorder in Hematopoietic Stem Cell Transplantation

    Directory of Open Access Journals (Sweden)

    S. Feuillet

    2009-01-01

    Full Text Available The Epstein-Barr virus (EBV associated Post-Transplant Lymphoproliferative Disorders (PTLD are increasingly recognized as a fatal complication of hematological stem cell transplantation (HSCT. Thoracic involvement, that may be isolated or part of a disseminated disease, usually encompasses pulmonary nodules or masses and mediastinal lymph node enlargement. The current case study presents 2 patients who underwent HSCT, one allogenic and the other autologous, who developed an exceptional endobronchial EBV related PTLD. The first patient had a fleshy white endobronchial mass resulting in a right upper lobe atelectasis and the second had an extensive necrotising mucosa from trachea to both basal bronchi without any significant change of lung parenchyma on the CT scan. In both cases, the diagnosis was made by bronchial biopsies. Physicians should be aware of an endobronchial pattern of EBV associated PTLD after HSCT to permit quick diagnosis and therapeutic intervention.

  8. Posttransplant Lymphoproliferative Disorder in a Patient with Worsening Ascites after Liver Transplantation

    Directory of Open Access Journals (Sweden)

    Harsh D. Patel

    2017-01-01

    Full Text Available Posttransplant lymphoproliferative disorder (PTLD is a spectrum of diseases that involves abnormal lymphoid and/or plasmacytic proliferation in patients with solid organ or hematopoietic cell transplantation. It is a condition with a low incidence of 3.5–4.3% in liver transplant (LT recipients. This case involves a 63-year-old male with history of LT for chronic HCV induced cirrhosis who presented with abdominal distension related to worsening ascites. Cytological ascitic fluid analysis revealed EBV (+ malignant cells without a malignant focal point on imaging. Diagnosis of monomorphic PTLD with primary effusion lymphoma-like morphology and immunophenotype was established. This case highlights the complexity in diagnosis, different diagnostic modalities, and rare clinical presentations of PTLD.

  9. HLA associations and risk of posttransplant lymphoproliferative disorder in Danish population-based cohort

    DEFF Research Database (Denmark)

    Vase, Maja Ølholm; Maksten, Eva Futtrup; Strandhave, Charlotte

    2015-01-01

    Background: Posttransplant lymphoproliferative disorder (PTLD) is a feared complication to organ transplantation, associated with substantial morbidity and inferior survival. Risk factors for PTLD include T cell–depleting induction therapy and primary infection or reactivation of Epstein-Barr virus....... Possible associations between certain HLA types and the risk of developing PTLD have been reported by other investigators; however, results are conflicting. Methods: We conducted a retrospective, population-based study on 4295 Danish solid organ transplant patients from the Scandiatransplant database...... can be clinically useful after transplantation in personalized monitoring schemes. Given the strong linkage disequilibrium in the HLA region, the associations must be interpreted carefully. The large size, virtually complete ascertainment of cases and no loss to follow-up remain important strengths...

  10. Efficacy of Low-Dose Protocol in Follow-Up of Lymphoproliferative Disorders - Preliminary Results

    International Nuclear Information System (INIS)

    Popic-Ramac, J.; Brnic, Z.; Klasic, B.; Hebrang, A.; Knezevic, Z.

    2011-01-01

    Most medically-related radiation is caused by diagnostic examinations, in particular by computed tomography (CT). The purpose of this research is to reduce radiation doses faced by the population frequently exposed to such procedures-those with lymphoproliferative disorders. The research was conducted comparing radiation-exposition doses received by the radiosensitive organs (thyroid, lens, breast and gonad) using the standard thoracic CT protocol with the radiation received using the low-dose protocol, while maintaining display quality. The standard-dose thoracic protocol implies 120 kV and 150 mAs. The low-dose protocol was conducted on the same device using 120 kV and 30 mAs. We confirmed the hypothesis that the use of the low-dose thoracic CT protocol leads to a reduction in radiation dose without compromising display quality. It is further expected that a reduction in doses will reduce the risk of radiation-related mutations. (author)

  11. Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines.

    Science.gov (United States)

    Parker, Anne; Bowles, Kristin; Bradley, J Andrew; Emery, Vincent; Featherstone, Carrie; Gupte, Girish; Marcus, Robert; Parameshwar, Jayan; Ramsay, Alan; Newstead, Charles

    2010-06-01

    A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.

  12. Epstein-Barr virus in inflammatory bowel disease: the spectrum of intestinal lymphoproliferative disorders.

    Science.gov (United States)

    Nissen, Loes H C; Nagtegaal, Iris D; de Jong, Dirk J; Kievit, Wietske; Derikx, Lauranne A A P; Groenen, Patricia J T A; van Krieken, J Han J M; Hoentjen, Frank

    2015-05-01

    Inflammatory bowel disease (IBD) patients on thiopurine therapy are at increased risk of Epstein-Barr virus (EBV)-associated lymphomas. This virus is frequently detected in the intestinal mucosa of IBD patients and may cause a wide spectrum of lymphoproliferations similar to post-transplantation lymphoproliferative disorders (PTLDs). We aimed to assess whether histological aberrations aid in predicting EBV presence and to correlate histological assessment and EBV load with disease outcome in IBD. We included all IBD patients from our centre who underwent EBV testing of intestinal biopsies between January 2004 and October 2013. All biopsies were classified according to the WHO PTLD classification and the EBV load was scored per high-power field (HPF). Clinical data were collected from patient charts. Reported clinical outcomes included colectomy, need for chemotherapy and mortality. Our cohort included 58 patients: 28 were EBV-positive and 30 EBV-negative. An atypical infiltrate was seen more frequently in EBV-positive than in EBV-negative patients (57.1 versus 3.3%; p < 0.001). A high EBV load occurred more frequently in EBV-positive patients undergoing colectomy than in EBV-positive patients without colectomy (50.0 versus 10.0%; p = 0.048). Monomorphic lymphoproliferative disorders, including two overt lymphomas, were present in 10 patients. Reduction of immunosuppression resulted in histological normalization and loss of EBV expression in seven of eight non-lymphoma patients. The presence of atypical infiltrate in the intestinal mucosa of IBD patients warrants EBV testing. Reduction of immunosuppression is an effective strategy to achieve morphological normalization and loss of EBV. Lymphoproliferation related to IBD appears to have less aggressive clinical behaviour than PTLDs. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  13. Post-transplant lymphoproliferative disorder in the pelvis successfully treated with consolidative radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Habibeh, Omar; Elsayad, Khaled; Kriz, Jan; Haverkamp, Uwe; Eich, Hans Theodor [University Hospital of Muenster, Department of Radiation Oncology, Muenster (Germany)

    2017-01-15

    Post-transplant lymphoproliferative disorders (PTLDs) are aggressive malignancies which represent one of the major post-transplant complications. However, treatment options vary significantly and localized disease may be curatively treated with radiotherapy (RT) or surgery. We report a case of recurrent rectal PTLD, which was successfully treated by chemoimmunotherapy followed by RT. We describe a patient who developed a rectal lymphoproliferative lesion 11 years after kidney transplant, which was successfully treated with consolidative RT using 25.4 Gy sequential to chemoimmunotherapy (R-CHOP). RT was well tolerated and the patient showed no signs of grade 3 or 4 toxicity. This patient is free of recurrence 52 months after RT, with an overall survival of 62 months since diagnosis. Conventionally fractionated moderate-dose RT appears to be a tolerable and effective treatment option for localized PTLD if a sufficient systemic treatment cannot be applied. (orig.) [German] Posttransplantationslymphoproliferative Erkrankungen (PTLDs) sind eine haeufige Komplikation nach einer Organtransplantation. Nichtdestotrotz unterscheiden sich die Behandlungsmoeglichkeiten signifikant und vor allem lokalisierte Stadien koennen kurativ entweder mit Strahlentherapie (RT) und/oder Operation behandelt werden. Wir berichten ueber einen Fall einer rezidivierten rektalen PTLD, die erfolgreich mit einer Chemoimmuntherapie mit anschliessender RT behandelt wurde. Wir beschreiben einen Patienten der 11 Jahre nach einer Nierentransplantation eine PTLD entwickelte. Diese wurde erfolgreich mit konsolidierender RT (25,4 Gy) im Anschluss an eine Chemoimmuntherapie (R-CHOP) behandelt. Die RT wurde komplikationslos vertragen und es zeigten sich keine Nebenwirkungen. Das rezidivfreie Ueberleben betrug zum Zeitpunkt der letzten Nachsorgeuntersuchung 52 Monate mit einer Gesamtueberlebenszeit von 62 Monaten seit der Diagnose. Die konventionelle fraktionierte moderat dosierte RT scheint eine gut

  14. Characterization of optical systems for the ALPS II experiment

    International Nuclear Information System (INIS)

    Spector, Aaron D.; Baehre, Robin; Willke, Benno; Hannover Univ.

    2016-09-01

    ALPS II is a light shining through a wall style experiment that will use the principle of resonant enhancement to boost the conversion and reconversion probabilities of photons to relativistic WISPs. This will require the use of long baseline low-loss optical cavities. Very high power build up factors in the cavities must be achieved in order to reach the design sensitivity of ALPS II. This necessitates a number of different sophisticated optical and control systems to maintain the resonance and ensure maximal coupling between the laser and the cavity. In this paper we report on the results of the characterization of these optical systems with a 20m cavity and discuss the results in the context of ALPS II.

  15. Associations among Epstein-Barr virus subtypes, human leukocyte antigen class I alleles, and the development of posttransplantation lymphoproliferative disorder in bone marrow transplant recipients

    NARCIS (Netherlands)

    Görzer, Irene; Puchhammer-Stöckl, Elisabeth; van Esser, Joost W J; Niesters, Hubert G M; Cornelissen, Jan J

    2007-01-01

    The association between Epstein-Barr virus subtype, human leukocyte antigen class I alleles, and the development of posttransplantation lymphoproliferative disorder was examined in a group of 25 bone marrow transplant recipients. A highly statistically significant correlation was observed between

  16. Small intestinal involvement by lymphoproliferative disorders post-renal transplantation: A report from the post-transplant lymphoproliferative disorder international survey

    Directory of Open Access Journals (Sweden)

    Hossein Khedmat

    2013-01-01

    Full Text Available In this study, data on post-renal transplant lymphoproliferative disorders (PTLD collected from the existing literature were pooled and analyzed to compare the characteristics, predictors and prognosis of small intestinal PTLDs. We performed a comprehensive search for the available data by Pubmed and Google scholar search engines for reports on this subject. Data from 18 previously published studies, comprising 120 renal allograft recipients, were included in the analysis. Renal transplant recipients with intestinal PTLD were significantly less likely to have Hogkin′s and Hogkin′s-like lesions (P = 0.044 and to be younger at the time of transplan-tation (P = 0.07. Except for Hodgkin′s-like lesions, histopathological evaluations elsewhere were comparable between the group with PTLD in the small intestine and age- and sex-matched renal transplant recipients with PTLD in other sites. The overall mortality was relatively higher in the control group (P = 0.09. When death only due to PTLD was used as the outcome, a trend toward better outcome was seen for the intestinal PTLD group compared with the other localizations (P = 0.1. The 1- and 5-year survival rates for intestinal PTLD patients were 57% and 37%, respectively, compared with 54% and 21%, respectively, for the control group. According to our findings based on analysis of international data, renal transplant patients with small intestinal PTLD are more likely to be of younger age but less frequently represent Hodgkin′s and Hodgkin′s-like lesions. They also have better patient survival compared with transplant recipients with PTLD in other locations. Further multi-center prospective studies are needed to confirm our results.

  17. Water Management Strategies against Water Shortage in the Alps (Invited)

    Science.gov (United States)

    de Jong, C.

    2009-12-01

    In the European Alps water has been perceived as ubiquitous and not the subject of management. Climate change and anthropogenic pressures have changed demand and supply relations rapidly and over the last 10 years, water problems have increasingly become apparent over temporal and spatial hotspots. Stakeholders in the Alpine Space have been confronted with water management problems in agriculture, tourism and hydropower to such an extent that they approached scientists to create solution strategies based on adaptation and mitigation. In this context, Alp-Water-Scarce, a European project on Water Management Strategies against Water Scarcity in the Alps was funded by the Alpine Space programme as part of the "European Territorial Cooperation" scheme. It has 17 project partners from Austria Switzerland, France, Italy and Slovenia from local governments, provinces, federal institutes and offices, universities, regional agencies, alpine societies, geological surveys, and chambers of agriculture and forestry. The Lead Partner is the Mountain Institute in Savoy, Rhone-Alpes, France. The main challenges of this project are to create local Early Warning Systems against Water Scarcity in the Alps. This system is based on strengthening existing long-term monitoring and modeling and creating new measuring networks in those countries where they do not yet exist. It is anchored strongly and actively within a Stakeholder Interaction Forum linked across comparative and contrasting regions across the Alps. The Early Warning System is based on the linkage and improvement of field monitoring and assemblage of qualitative and quantitative data derived both from natural water reservoirs as well as from anthropogenic water use in 28 selected pilot regions selected in France, Italy, Austria, Slovenia and Switzerland. The objectives are to improve water management at the short term (annual scale) and long term (using future scenarios) based on modelling and application of climate change

  18. Systemic Epstein-Barr Virus-positive T-Cell Lymphoproliferative Disease of Childhood With Good Response to Steroid Therapy.

    Science.gov (United States)

    Kim, Do-Hoon; Kim, Myungshin; Kim, Yonggoo; Han, Kyungja; Han, Eunhee; Lee, Jae Wook; Chung, Nack-Gyun; Cho, Bin

    2017-11-01

    Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease of childhood is a rare disease and has a very fulminant clinical course with high mortality. A 21-month-old female patient was referred to our hospital with a 1 week history of fever and was subsequently diagnosed with systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood. After starting treatment with dexamethasone, she showed early defervescence and improvement of laboratory parameters, and has remained disease-free after stopping steroid treatment, although longer follow-up is necessary. Our report underscores the possibility that this disease entity may be heterogenous in terms of prognosis.

  19. Isolated Post-Transplantation Lymphoproliferative Disease Involving the Breast and Axilla as Peripheral T-cell Lymphoma

    OpenAIRE

    Hwang, Ji-Young; Cha, Eun Suk; Lee, Jee Eun; Sung, Sun Hee

    2013-01-01

    Post-transplantation lymphoproliferative disorders (PTLDs) are a heterogeneous group of diseases that represent serious complications following immunosuppressive therapy for solid organ or hematopoietic-cell recipients. In contrast to B-cell PTLD, T-cell PTLD is less frequent and is not usually associated with Epstein Barr Virus infection. Moreover, to our knowledge, isolated T-cell PTLD involving the breast is extremely rare and this condition has never been reported previously in the litera...

  20. The Geology of the Bergamasc Alps Lombardia Italy

    NARCIS (Netherlands)

    Sitter, de L.U.; Sitter-Koomans, de C.M.

    1949-01-01

    In the Bergamasc Alps we have observed one major unconformity between the Basement rock and the overlying Permian. The total absence of any recognisable Palaeozoic sedimentary rocks accentuates this unconformity, and moreover this enormous hiatus makes the dating of any Palaeozoic event impossible.

  1. Traditional phytotherapy of the Albanians of Lepushe, Nothern Albanian Alps

    NARCIS (Netherlands)

    Pieroni, A.; Dibra, B.; Grishaj, G.; Grishaj, I.; Maçai, S.G.

    2005-01-01

    An ethnobotanical and ethnopharmacognostic survey has been carried out in one of the most isolated mountainous area in Europe: the village of Lepushe and its surrounding territory, in the Northern Albanian Alps. Approximately 70 botanical taxa and 160 preparations, mainly derived from plants, but

  2. Green light for neutrino beam to pass below the Alps

    CERN Multimedia

    Abbott, A

    1999-01-01

    CERN council have approved a plan to send a beam of muon neutrinos under the Alps from Geneva to the Gran Sasso laboratories near Rome. INFN is organising two experiments - OPERA and ICANOE, to study the neutrino oscillations as they travel (1/2 pg)

  3. Australian Alps: Kosciuszko, Alpine and Namadgi National Parks (Second Edition

    Directory of Open Access Journals (Sweden)

    Nicole Porter

    2017-02-01

    Full Text Available Reviewed: Australian Alps: Kosciuszko, Alpine and Namadgi National Parks (Second Edition By Deidre Slattery. Clayton South, Australia: CSIRO Publishing, 2015. xvii + 302 pp. AU$ 45.00, US$ 35.95. ISBN 978-1-486-30171-3.

  4. Treatment of post-transplantation lymphoproliferative disorders after kidney transplant with rituximab and conversion to m-TOR inhibitor.

    Science.gov (United States)

    Nieto-Rios, John Fredy; Gómez de Los Ríos, Sandra Milena; Serna-Higuita, Lina María; Ocampo-Kohn, Catalina; Aristizabal-Alzate, Arbey; Gálvez-Cárdenas, Kenny Mauricio; Zuluaga-Valencia, Gustavo Adolfo

    2016-12-30

    Post-transplantation lymphoproliferative disorders are serious complications of organ transplantation which treatment is not yet standardized. To describe the clinical response, overall and graft survival of patients in our center with this complication after kidney transplantation, which received rituximab as part of their treatment as well as conversion to m-TOR. Retrospective study, which included patients, diagnosed with post-transplant lymphoproliferative disorders after kidney transplantation from January 2011 to July 2014. Eight cases were found with a wide spectrum of clinical presentations. Most had monomorphic histology, 85% were associated with Epstein-Barr virus, 25% of patients had tumor involvement of the renal graft, and 12.5% ​​had primary central nervous system lymphoma. All patients were managed with reduction of immunosuppression, conversion to m-TOR (except one who lost the graft at diagnosis) and rituximab-based therapy. The overall response rate was 87.5% (62.5% complete response, 25% partial response). Survival was 87.5% with a median follow-up of 34 months. An additional patient lost the graft, with chronic nephropathy already known. All the remaining patients had stable renal function. There are no standardized treatment regimens for lymphoproliferative disorders after kidney transplantation, but these patients can be managed successfully with reduction of immunosuppression, conversion to m-TOR and rituximab-based schemes.

  5. New, rare or remarkable microfungi in the Italian Alps (Carnic Alps)--part I--ascomycotina.

    Science.gov (United States)

    Feige, G B; Ale-Agha, N; Jensen, M; Christiaans, B; Kricke, R

    2004-01-01

    During our observations in the SE part of the Carnic Alps in the year 2003 we were able to collect and identify 35 ascomycetes on trees and dead wood. Among these one can find numerous ascomycetes of different orders e.g. Pyrenomycetes, Loculoascomycetes and Discomycetes. Some species like Botryosphaeria ribis GROSENLUCHER & DUGGAR on Ribes alpinum L., Dothiora pyrenophora (FR.) FR. on Sorbus aucuparia L., Gemmamyces piceae (BORTH.) CASAGO. on Picea excelsa (LAM.) LINK, Glomerella montana (SACC.) v. ARX & E. MULLER on Sesleria caerulea (L.) ARD, Hymenoscyphus immutabilis (Fuck.) Dennis on Alnus incana (L.) Moench, Hysterographium fraxini (PERS. Ex. FR.) de Not. on Fraxinus ornus L., Lachnellula willkommii (Hartig) DENNIS [= Trichascyphella willkommii (Hartig) NANNF.] on Larix decidua MILL.,Leptosphaeria lycopodina (Mont.) SACC. on Lycopodium annotinum L., Mollisia adenostylidis REHM. on Adenostyles glabra (MILL.) DC., Pezicula cinnamomea (DC.)SACC. [ana: Cryptosporiopsis quercina PETRAK] on Quercus robur L., Pyrenopeziza petiolaris (A. & S. Ex FR.) NANNF. on Acer pseudoplatanus L., Tapesia rosae (PERS.) FUCKEL on Rosa canina L., are new for this area. All specimen are deposited in the Herbarium ESS Mycotheca Parva, Collection G.B. Feige/N. Ale-Agha.

  6. Comment diffuser les savoirs à travers les Alpes ?

    Directory of Open Access Journals (Sweden)

    Wolfgang Pfefferkorn

    2009-03-01

    Full Text Available CIPRA’s Future in the Alps Project aims at showcasing examples of successful implementation and successful projects in the Alps, and making available to others the extensive pool of experience and practical knowledge that lies in these projects. But how to transfer knowledge in an area of some 14 million inhabitants with several linguistic and cultural regions in which thousands of projects are carried out each year, that all kinds of players who work and life in completely different contexts are able to learn and benefit from one another? How do you go about something like that?Le projet « Avenir dans les Alpes » de la CIPRA (Commission Internationale pour la Protection des Alpes a pour objectif de présenter des exemples de réalisations et de projets réussis dans les Alpes, et de mettre à disposition du public l’ensemble de l’expérience et des connaissances pratiques acquises dans le cadre de ces projets. Cependant, comment transférer les savoirs dans une zone comptant quelque 14 millions d’habitants, composée de plusieurs régions linguistiques et culturelles dans lesquelles des milliers de projets sont menés à bien chaque année, et dont tous les acteurs, qui travaillent et vivent dans des contextes complètement différents, sont capables d’apprendre et de tirer profit les uns des autres ? Comment aborder ce genre de cas ?

  7. Correlation between flow cytometry and histologic findings: ten year experience in the investigation of lymphoproliferative diseases

    Directory of Open Access Journals (Sweden)

    Alanna Mara Pinheiro Sobreira Bezerra

    2011-06-01

    Full Text Available Objective: To demonstrate the advantages of correlatingflow cytometry immunophenotyping with the pathology/immunohistochemistry of lymph nodes or nodules in the diagnosisof lymphoproliferative diseases. Methods: A retrospective studywas carried out of 157 biopsy or fine-needle aspiration lymph nodes/nodule specimens taken from 142 patients, from 1999 and 2009.The specimens were simultaneously studied with flow cytometryand pathology at Hospital Israelita Albert Einstein. The specimenswere prepared in hematoxylin/eosin, Giemsa, or monoclonal antibodystained slides for detecting specific antibodies for the purposesof pathology/immunohistochemical analysis. The samples werehemolyzed and marked with different monoclonal antibody panels fordifferent antigens in flow cytometry immunophenotyping. Results:The diagnostic results of pathology/immunohistochemical studiesand flow cytometry immunophenotyping agreed in 115 patients(81%, corresponding to 127 specimens, as follows according tothe pathologic diagnosis: 63 patients with non-Hodgkin’s B-celllymphoma; 26 patients with reactive lymphoid hyperplasia; 5 patientswith non-Hodgkin’s T-cell lymphoma; 4 patients with atypical lymphoidproliferation; 5 patients with a chronic granulomatous inflammatoryprocess; 5 patients with a non-hematologic diagnosis; 2 patientswith granulocytic sarcoma; 2 patients with thymoma; 1 patientwith byphenotypic leukemia; 1 patient with kappa plasmocytoma;1 patient with Hodgkin’s lymphoma. Subtypes of lymphomas couldbe classified by associating the two techniques: 19 patients withfollicular lymphoma; 15 patients with diffuse large B-cell lymphoma; 7patients with small lymphocytic B-cell lymphoma/chronic lymphocyticleukemia; 3 patients with mantle cell lymphoma; 1 patient withBurkitt’s lymphoma; 1 patient with MALT type lymphoma; 1 patientwith post-transplant lymphoproliferative disease; 2 patients with highgrade non-Hodgkin’s B-cell lymphoma; 1 patient with low grade

  8. Gene Expression of Lytic Endopeptidases AlpA and AlpB from Lysobacter sp. XL1 in Pseudomonads.

    Science.gov (United States)

    Tsfasman, Irina M; Lapteva, Yulia S; Krasovskaya, Ludmila A; Kudryakova, Irina V; Vasilyeva, Natalia V; Granovsky, Igor E; Stepnaya, Olga A

    2015-01-01

    Development of an efficient expression system for (especially secreted) bacterial lytic enzymes is a complicated task due to the specificity of their action. The substrate for such enzymes is peptidoglycan, the main structural component of bacterial cell walls. For this reason, expression of recombinant lytic proteins is often accompanied with lysis of the producing bacterium. This paper presents data on the construction of an inducible system for expression of the lytic peptidases AlpA and AlpB from Lysobacter sp. XL1 in Pseudomonas fluorescens Q2-87, which provides for the successful secretion of these proteins into the culture liquid. In this system, the endopeptidase gene under control of the T7lac promoter was integrated into the bacterial chromosome, as well as the Escherichia coli lactose operon repressor protein gene. The T7 pol gene under lac promoter control, which encodes the phage T7 RNA polymerase, is maintained in Pseudomonas cells on the plasmids. Media and cultivation conditions for the recombinant strains were selected to enable the production of AlpA and AlpB by a simple purification protocol. Production of recombinant lytic enzymes should contribute to the development of new-generation antimicrobial drugs whose application will not be accompanied by selection of resistant microorganisms. © 2015 S. Karger AG, Basel.

  9. [Lymphocytic Clonal Expansion in Adult Patients with Epstein-Barr Virus-Associated Lymphoproliferative Disease].

    Science.gov (United States)

    Zhong, Feng-Luan; Zhang, Hong-Yu; Zhang, Qian; Feng, Jia; Zhang, Wen-Li; Xu, Lei; Xu, Hai-Chan; Wen, Juan-Juan; Meng, Qing-Xiang

    2017-12-01

    To explore the lymphocytic clonal expansion in adult patients with Epstein-Barr virus-associated lymphoproliferative diseases (EBV+LPD), and to investigate the experimental methods for EBV+LPD cells so as to provide a more objective measure for the diagnosis, classification and prognosis in the early stage of this disease. Peripheral blood samples from 5 patients with EBV+LPD, 4 patients with adult infectious mononucleosis(IM) as negative control and 3 patients with acute NK-cell leukemia(ANKL) as positive control were collected. Prior to immunochemotherapy, viral loads and clonality were analysed by flow cytometry (FCM), T cell receptor gene rearrangement (TCR) was detected by real-time polymerase chain reaction (RT-PCR), and diversity of EB virus terminal repeat (EBV-TR) was detected by Southern blot. FCM showed only 1 case with clonal TCRVβ in 5 patients with EBV+LPD, TCR clonal expansion could be detected both in patients with IM(4 of 4) and 4 patients with EBV+LPD(4 of 5), Out of patients with EBV+LPD, 1 patient displayed a monoclonal band and 2 patients showed oligoclonal bands when detecting EBV-TR by southen blot. Detecting the diversity of EBV-TR by Southern blot may be the most objective way to reflex clonal transformation of EBV+LPD, which is of great benefit to the diagnosis, classification and prognosis in the early stage of this disease.

  10. Epstein-Barr virus lymphoproliferative disease after hematopoietic stem cell transplant.

    Science.gov (United States)

    Rouce, Rayne H; Louis, Chrystal U; Heslop, Helen E

    2014-11-01

    Epstein-Barr virus (EBV) reactivation can cause significant morbidity and mortality after allogeneic hematopoietic stem cell transplant. Delays in reconstitution of EBV-specific T lymphocyte activity can lead to life-threatening EBV lymphoproliferative disease (EBV-PTLD). This review highlights recent advances in the understanding of pathophysiology, risk factors, diagnosis, and management of EBV viremia and PTLD. During the past decade, early detection strategies, such as serial measurement of EBV-DNA load, have helped identify high-risk patients and diagnose early lymphoproliferation. The most significant advances have come in the form of innovative treatment options, including manipulation of the balance between outgrowing EBV-infected B cells and the EBV cytotoxic T lymphocyte response, and targeting infected B cells with monoclonal antibodies, chemotherapy, unmanipulated donor lymphocytes, and donor or more recently third-party EBV cytotoxic T lymphocytes. Defining criteria for preemptive therapy remains a challenge. EBV reactivation is a significant complication after stem cell transplant. Continued improvements in risk stratification and treatment options are required to improve the morbidity and mortality caused by EBV-associated diseases. Current approaches use rituximab to deplete B cells or adoptive transfer of EBV cytotoxic T lymphocyte to reconstitute immunity. The availability of rapid EBV-specific T cell products offers the possibility of improved outcomes.

  11. Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication.

    Science.gov (United States)

    Bilger, Andrea; Plowshay, Julie; Ma, Shidong; Nawandar, Dhananjay; Barlow, Elizabeth A; Romero-Masters, James C; Bristol, Jillian A; Li, Zhe; Tsai, Ming-Han; Delecluse, Henri-Jacques; Kenney, Shannon C

    2017-07-04

    EBV infection causes mononucleosis and is associated with specific subsets of B cell lymphomas. Immunosuppressed patients such as organ transplant recipients are particularly susceptible to EBV-induced lymphoproliferative disease (LPD), which can be fatal. Leflunomide (a drug used to treat rheumatoid arthritis) and its active metabolite teriflunomide (used to treat multiple sclerosis) inhibit de novo pyrimidine synthesis by targeting the cellular dihydroorotate dehydrogenase, thereby decreasing T cell proliferation. Leflunomide also inhibits the replication of cytomegalovirus and BK virus via both "on target" and "off target" mechanisms and is increasingly used to treat these viruses in organ transplant recipients. However, whether leflunomide/teriflunomide block EBV replication or inhibit EBV-mediated B cell transformation is currently unknown. We show that teriflunomide inhibits cellular proliferation, and promotes apoptosis, in EBV-transformed B cells in vitro at a clinically relevant dose. In addition, teriflunomide prevents the development of EBV-induced lymphomas in both a humanized mouse model and a xenograft model. Furthermore, teriflunomide inhibits lytic EBV infection in vitro both by preventing the initial steps of lytic viral reactivation, and by blocking lytic viral DNA replication. Leflunomide/teriflunomide might therefore be clinically useful for preventing EBV-induced LPD in patients who have high EBV loads yet require continued immunosuppression.

  12. Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease.

    Science.gov (United States)

    Wada, Taizo; Toma, Tomoko; Miyazawa, Hanae; Koizumi, Eiko; Shirahashi, Tetsujiro; Matsuda, Yusuke; Yachie, Akihiro

    2018-04-01

    Epstein-Barr virus (EBV)-associated T- or natural killer (NK)-cell lymphoproliferative disease (LPD) is a heterogeneous group of disorders characterized by chronic proliferation of EBV-infected lymphocytes. Patients may present with severe skin manifestations, including hypersensitivity to mosquito bites (HMB) and hydroa vacciniforme (HV)-like eruption, which are characterized by blister formation and necrotic ulceration. Skin biopsy specimens show inflammatory reactions comprising EBV-infected lymphocytes. However, blister fluids have not been fully assessed in patients with this disease. Blister fluids were collected from three patients with EBV-associated LPD: two with HMB and one with HV. Immunophenotyping of blister lymphocytes and measurement of tumor necrosis factor (TNF)-α in blister fluids were performed. The patients with HMB and HV exhibited markedly increased percentages of NK and γδ T cells, respectively, in both peripheral blood and blister fluids. These NK and γδ T cells strongly expressed the activation marker human leukocyte antigen-DR and were considered to be cellular targets of EBV infections. TNF-α was highly elevated in all blister fluids. Severe local skin reactions of EBV-associated LPD may be associated with infiltrating EBV-infected lymphocytes and a high TNF-α concentration in blister fluids. © 2018 Japanese Dermatological Association.

  13. Epstein-Barr Virus-associated lymphoproliferative disorders: experimental and clinical developments

    Science.gov (United States)

    Geng, Lingyun; Wang, Xin

    2015-01-01

    Epstein-Barr Virus (EBV), the first human virus related to oncogenesis, was initially identified in a Burkitt lymphoma cell line in 1964. EBV infects over 90% of the world’s population. Most infected people maintain an asymptomatic but persistent EBV infection lifelong. However, in some individuals, EBV infection has been involved in the development of cancer and autoimmune disease. Nowadays, oncogenic potential of EBV has been intensively studied in a wide range of human neoplasms, including Hodgkin’s lymphoma (HL), non-Hodgkin’s lymphoma (NHL), nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), etc. EBV encodes a series of viral protein and miRNAs, promoting its persistent infection and the transformation of EBV-infected cells. Although the exact role of EBV in the oncogenesis remains to be clarified, novel diagnostic and targeted therapeutic approaches are encouraging for the management of EBV-related malignancies. This review mainly focuses on the experimental and clinical advances of EBV-associated lymphoproliferative disorders. PMID:26628948

  14. Minimal disease detection of B-cell lymphoproliferative disorders by flow cytometry: multidimensional cluster analysis.

    Science.gov (United States)

    Duque, Ricardo E

    2012-04-01

    Flow cytometric analysis of cell suspensions involves the sequential 'registration' of intrinsic and extrinsic parameters of thousands of cells in list mode files. Thus, it is almost irresistible to describe phenomena in numerical terms or by 'ratios' that have the appearance of 'accuracy' due to the presence of numbers obtained from thousands of cells. The concepts involved in the detection and characterization of B cell lymphoproliferative processes are revisited in this paper by identifying parameters that, when analyzed appropriately, are both necessary and sufficient. The neoplastic process (cluster) can be visualized easily because the parameters that distinguish it form a cluster in multidimensional space that is unique and distinguishable from neighboring clusters that are not of diagnostic interest but serve to provide a background. For B cell neoplasia it is operationally necessary to identify the multidimensional space occupied by a cluster whose kappa:lambda ratio is 100:0 or 0:100. Thus, the concept of kappa:lambda ratio is without meaning and would not detect B cell neoplasia in an unacceptably high number of cases.

  15. In Vitro Evaluation of Colloidal Silver on Immune Function: Anti lymphoproliferative Activity

    International Nuclear Information System (INIS)

    Franco-Molina, M. A.; Mendoza-Gamboa, E.; Zarate-Trivino, D. G.; Coronado-Cerda, E.E.; Alcocer-Gonzalez, J. M.; Resendez-Perez, D.; Rodriguez-Salazar, M.C.; Rivera-Morales, L.G.; Tamez-Guerra, R.; Rodriguez-Padilla, C.

    2016-01-01

    Colloidal silver (AgC) is currently used by humans and it can be internalized through inhalation, injection, ingestion, and dermal contact. However, there is limited information about immunological activity; more investigations using colloidal silver are needed. In the present study, the effects of AgC (17.5 ng/m L) on immunological parameters (proliferation and immuno phenotyping) using human peripheral blood mononuclear cells (PBMC) and macrophages (phagocytosis) and cytotoxicity on leukemia and lymphoma cancer cell lines (1.75 to 17.5 ng/m L) were investigated. AgC was observed to significantly ρ) decrease interleukin-2 (I L-2) production and proliferation induced by phytohemagglutinin or concanavalin A in PBMC without affecting its cell viability but with cytotoxic effect on cancer cells. IL-2, IL-4, IL-6, IL-10, INF-γ, and IL_-17 A cytokines production and CD3"+, CD3"-CD19"+, CD3"+CD4"+, CD3"+CD8"+, and CD16"+CD56"+ PBMC phenotypes were not affected by AgC. The present study demonstrates that colloidal silver is harmless and nontoxic to the immune system cells and its ability to interfere with the immune response by decreasing cell proliferation when stimulated with mitogens demonstrated the anti lymphoproliferative potential of AgC

  16. Recurrent posttransplant lymphoproliferative disorder involving the larynx and trachea: case report and review of the literature.

    Science.gov (United States)

    Banks, Caroline A; Meier, Jeremy D; Stallworth, Christina R; White, David R

    2012-05-01

    Posttransplant lymphoproliferative disorder (PTLD) is a well-recognized complication of solid organ transplantation and commonly affects upper airway lymphoid tissue. Tracheal and laryngeal involvement in patients with PTLD, however, is rare. We present one such case. We report the case of a patient with recurrent PTLD involving the larynx and trachea and describe the presentation, evaluation, management, and outcome. An 11-year-old boy who underwent bilateral nephrectomy and renal transplantation as an infant was admitted to the hospital with chronic cough, fever, stridor, and dyspnea. His post-transplantation course was complicated by PTLD in cervical lymph nodes at 9 years of age that was successfully treated with chemotherapy. A computed tomographic scan during his present admission revealed supraglottic swelling, a distal tracheal mass, and paratracheal lymph node enlargement. The patient underwent laryngoscopy and bronchoscopy with biopsy specimens taken from the right laryngeal ventricle and distal trachea. Pathologic examination yielded a diagnosis of Epstein-Barr virus-positive PTLD. The patient was treated with chemotherapy, which resulted in resolution of the airway lesions, as seen on repeat bronchoscopy. This is the first report, to our knowledge, of recurrent PTLD involving simultaneous lesions in the larynx and the trachea. PTLD in the head and neck can present as lymphoid hypertrophy, airway obstruction, stridor, or cough. A high degree of clinical suspicion is essential for prompt diagnosis of this life-threatening complication.

  17. Posttransplant Lymphoproliferative Disorder After Clinical Islet Transplantation: Report of the First Two Cases.

    Science.gov (United States)

    Peters, A; Olateju, T; Deschenes, J; Shankarnarayan, S H; Chua, N; Shapiro, A M J; Senior, P

    2017-09-01

    We report the first two cases of posttransplant lymphoproliferative disorder (PTLD) in recipients of islet transplants worldwide. First, a 44-year-old recipient of three islet infusions developed PTLD 80 months after his initial transplantation, presenting with abdominal pain and diffuse terminal ileum thickening on imaging. He was treated with surgical excision, reduction of immunosuppression, and rituximab. Seven months later, he developed central nervous system PTLD, presenting with vertigo and diplopia; immunosuppression was discontinued, resulting in graft loss, and he was given high-dose methotrexate and underwent consolidative autologous stem cell transplantation. He remains in remission 37 months after the initial diagnosis. Second, a 58-year-old female recipient of two islet infusions developed PTLD 24 months after initial islet infusion, presenting with pancytopenia secondary to extensive bone marrow involvement. Immunosuppression was discontinued, resulting in graft loss, and she received rituximab and chemotherapy, achieving complete remission. Both patients were monomorphic B cell PTLD subtype by histology and negative for Epstein-Barr virus in tissue or blood. These cases document the first occurrences of this rare complication in islet transplantation, likely secondary to prolonged, intensive immunosuppression, and highlight the varying clinical manifestations of PTLD. Further studies are needed to determine incidence rate and risk factors in islet transplantation. © 2017 The American Society of Transplantation and the American Society of Transplant Surgeons.

  18. Clonality assessment of lymphoproliferative lesions using the polymerase chain reaction: An analysis of two methods

    Directory of Open Access Journals (Sweden)

    Nikhil Moorchung

    2011-01-01

    Full Text Available Background: Lymphoid malignancies are a heterogeneous group of disorders which may be difficult to differentiate from reactive proliferations even after immunohistochemistry. Polymerase chain reaction (PCR is believed to be a good adjunct tool for diagnosis. Materials and Methods: We examined 24 cases of neoplastic and non-neoplastic lymphoproliferative lesions in this study and evaluated the PCR as an additional tool in the confirmation of the diagnosis. Two different PCR methodologies were evaluated. Results: In the evaluation of the T-cell PCR, it was seen that the correlation using both the commercial kits and the custom-synthesized primers was highly significant at a P value of 0.05. Conclusions: Both the methods showed an excellent concordance for T-cell γ gene rearrangements, However, the same was not seen in the B-cell receptor rearrangements. This may be because of the small sample size or the inability of consensus V primers to recognize complementary DNA sequences in all of the V segments.

  19. Molecular Pathogenesis of B-Cell Posttransplant Lymphoproliferative Disorder: What Do We Know So Far?

    Directory of Open Access Journals (Sweden)

    J. Morscio

    2013-01-01

    Full Text Available Posttransplant lymphoproliferative disorder (PTLD is a potentially fatal disease that arises in 2%–10% of solid organ and hematopoietic stem cell transplants and is most frequently of B-cell origin. This very heterogeneous disorder ranges from benign lymphoproliferations to malignant lymphomas, and despite the clear association with Epstein-Barr Virus (EBV infection, its etiology is still obscure. Although a number of risk factors have been identified (EBV serostatus, graft type, and immunosuppressive regimen, it is currently not possible to predict which transplant patient will eventually develop PTLD. Genetic studies have linked translocations (involving C-MYC, IGH, BCL-2, various copy number variations, DNA mutations (PIM1, PAX5, C-MYC, RhoH/TTF, and polymorphisms in both the host (IFN-gamma, IL-10, TGF-beta, HLA and the EBV genome to B-cell PTLD development. Furthermore, the tumor microenvironment seems to play an important role in the course of disease representing a local niche that can allow antitumor immune responses even in an immunocompromised host. Taken together, B-cell PTLD pathogenesis is very complex due to the interplay of many different (patient-dependent factors and requires thorough molecular analysis for the development of novel tailored therapies. This review aims at giving a global overview of the currently known parameters that contribute to the development of B-cell PTLD.

  20. Chemoimmunotherapy and withdrawal of immunosupression for monomorphic post-transplant lymphoproliferative disorders

    Science.gov (United States)

    Podoltsev, Nikolai; Zhang, Bingnan; Yao, Xiaopan; Bustillo, Ivan; Deng, Yanhong; Cooper, Dennis L.

    2013-01-01

    Introduction Monomorphic post-transplant lymphoproliferative disorders (PTLD) are the most aggressive type of PTLD occurring after solid organ transplantation (SOT). Current guidelines for treatment suggest a stepwise approach that includes a reduction of immunosuppression (RIS) with or without rituximab, followed by chemotherapy if there is no response. Nevertheless, recommendations regarding the extent and duration of RIS are non-standardized and RIS as an initial strategy may be associated with an unacceptably high frequency of graft loss and disease progression. Patients and Methods We reviewed the outcome of a combination program of aggressive chemo-immunotherapy and complete withdrawal of immunosuppression in treating 22 patients with monomorphic PTLD between January 1995 and August 2012. Results 12 of 22 patients (55%) received CHOP-R every 2 weeks (dose dense CHOP-R) and 10 patients received other doxorubicin-based regimens. There was no treatment related mortality (TRM). Complete response (CR) was seen in 91% of patients. Median overall survival was 9.61 years with 95% CI (5.21-10.74). Median progression free survival (PFS) was 5.39 years with 95% CI (2.10-10.74). The graft-rejection rate was 18% with 95% CI (0.03-0.34). Conclusion We conclude that the use of aggressive chemo-immunotherapy in combination with withdrawal of immunosuppression approach yields excellent results and should be prospectively studied in a multi-institutional setting. PMID:24035715

  1. Low incidence of lymphoproliferative disease post kidney transplantation with prevalent use of alemtuzumab

    Directory of Open Access Journals (Sweden)

    John Fredy Nieto-Ríos

    2014-01-01

    Full Text Available Introduction: It is well known that the incidence of malignancy is significantly higher in transplanted patients than in general population. The incidence of lymphoproliferative disease post-transplantation (PTLD is approximately of 1% to 2% in kidney transplantation recipients. Objective: The main objective of this study was to evaluate the PTLD incidence when monitoring kidney transplanted patients between the years 2005 and 2010. Methods: Kidney transplanted patients’ data was retrospectively taken between the years 2005 to 2010 in order to determine the number of PTLD cases according to the inductor scheme used. Results: 425 patients were transplanted between 2005 and 2010. They received alemtuzumab 76.2%, daclizumab 10.7%, basiliximab 3.6% and thymoglobulin 2.4%. The 7% did not receive antibody induction. During this period 2 cases of PTLD ocurred: One with multiple myeloma and the other with lymphoma. One of them had been treated with alemtuzumab and the other with thymoglobulin. Conclusions: The PTLD incidence in our group, where alemtuzumab was used predominantly as inductor, was very low; this might suggest that alemtuzumab is a medication that does not increase the risk of this kind of neoplasia.

  2. Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.

    Science.gov (United States)

    Chiang, Mark Y; Radojcic, Vedran; Maillard, Ivan

    2016-07-01

    This article highlights recent discoveries about Notch activation and its oncogenic functions in lymphoid malignancies, and discusses the therapeutic potential of Notch inhibition. NOTCH mutations arise in a broad spectrum of lymphoid malignancies and are increasingly scrutinized as putative therapeutic targets. In T-cell acute lymphoblastic leukemia (T-ALL), NOTCH1 mutations affect the extracellular negative regulatory region and lead to constitutive Notch activation, although mutated receptors remain sensitive to Notch ligands. Other NOTCH1 mutations in T-ALL and NOTCH1/2 mutations in multiple B-cell malignancies truncate the C-terminal proline (P), glutamic acid (E), serine (S), threonine (T)-rich (PEST) domain, leading to decreased Notch degradation after ligand-mediated activation. Thus, targeting Notch ligand-receptor interactions could provide therapeutic benefits. In addition, we discuss recent reports on clinical testing of Notch inhibitors in T-ALL that influenced contemporary thinking on the challenges of targeting Notch in cancer. We review advances in the laboratory to address these challenges in regards to drug targets, the Notch-driven metabolome, and the sophisticated protein-protein interactions at Notch-dependent superenhancers that underlie oncogenic Notch functions. Notch signaling is a recurrent oncogenic pathway in multiple T- and B-cell lymphoproliferative disorders. Understanding the complexity and consequences of Notch activation is critical to define optimal therapeutic strategies targeting the Notch pathway.

  3. The Italian experience in crossing the Alps and Apennines

    Energy Technology Data Exchange (ETDEWEB)

    Stella,; Olcese,

    1991-06-01

    Since the early 70's SNAM has completed a number of major projects: the pipelines importing gas from the Netherlands and the Soviet Union crossing the Alps and the TRASMED, which crosses the Apennines. More recently, improved technology applied in the eastern part of the Alps has made possible the doubling of the import pipeline from the Soviet Union. Details are given about methods used in these projects for geological-geomorphological surveys, engineering design and tunnel construction. The paper also describes how the problems posed by steep slopes and landslide areas are overcome by planning the most suitable geometry for the pipe and carrying out different kinds of drainage and retaining works, and how problems posed by crossing streams can be overcome by the creation of major hydraulic defences. Special care is taken to select a pipeline route which respects the environment and, where possible, avoids crossing places of interest such as archaeological sites or national parks etc. (orig./BWI).

  4. Fine-needle aspiration biopsy of lymphoproliferative disorders--interpretations based on morphologic criteria alone: results from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology.

    Science.gov (United States)

    Young, Nancy A; Moriarty, Ann T; Haja, Jennifer C; Wilbur, David C

    2006-12-01

    Diagnosis of lymphoproliferative disorders is one of the most challenging tasks faced by the cytologist. The initial cytomorphologic evaluation of lymphoproliferative lesions directs the choice of ancillary studies that ultimately lead to a diagnosis based on the World Health Organization classification system using a composite of clinical, morphologic, immunophenotypic, and molecular features. To evaluate the ability of participating laboratories in the College of American Pathologists Interlaboratory Comparison Program in Non-Gynecologic Cytopathology to appropriately categorize lymphoproliferative lesions based solely on cytomorphologic criteria. Laboratory responses for lymph node aspirates were examined. All responses were based on review of glass slides without ancillary immunologic or molecular data available. The benchmarking data provided for each specific diagnosis were analyzed, with a focus on the performance for evaluation of lymphoproliferative lesions. Based on morphology alone, responses for lymph node aspirates in the Non-Gynecologic Cytopathology program were correct to the exact reference diagnosis for 87.1% of Hodgkin lymphoma. Non-Hodgkin lymphoma was identified in 69.5% of the large cell non-Hodgkin lymphoma cases, of which 66.8% were correctly classified as large cell type. Non-Hodgkin lymphoma was identified in 68.1% of non-Hodgkin lymphoma, other than large cell cases, and of these, 94.7% were identified as other than large cell type. The spectrum of specific responses was consistent for lymphoproliferative lesions, with a reasonable differential diagnosis based on cytomorphology alone, which, in practice, facilitates the appropriate choice of immunophenotypic markers and other ancillary studies.

  5. What's new in ALPS-II

    Energy Technology Data Exchange (ETDEWEB)

    Doebrich, Babette; Collaboration: ALPS-II collaboration

    2013-09-15

    This proceedings contribution gives a brief experimental update of the 'Any light particle search (ALPS) -II' at DESY which will be sensitive to sub-eV, very weakly coupled particles beyond the Standard Model. First data on hidden sector photon parameter space through photon-hidden photon oscillations in vacuum is expected in 2014. Axion-like particle search (implying the installation of superconducting HERA magnets) could be realized in 2017.

  6. The onset of alpine pastoral systems in the Eastern Alps

    Science.gov (United States)

    Oeggl, Klaus; Festi, Daniela; Putzer, Andreas

    2015-04-01

    Since the discovery of the Neolithic glacier mummy "Ötzi" in the nival belt of the main Alpine ridge, the onset of alpine pasture is matter of a highly controversial debate both in archaeology and in palaeo-ecology of the Eastern Alps. The implication is that his sojourn in the high-altitudes of the Alps is considered to be connected with pastoral nomadism. Regrettably any archaeological evidence for the existence of such Neolithic alpine pastoral systems is missing up to now and the assumption is based on palynological data only. However, also the palynological record is ambiguous, because pasture indicators in the alpine regions react positive on grazing as well as on fertilization induced by a higher runoff of precipitation. Thus alpine pasture indicators reflect both grazing pressure and climatic change. Anyhow, alpine pastoral systems are a common practice in Alpine animal husbandry, but from an economic point of view such a seasonal vertical transhumance is costly. There are three main reasons for its practice: i) climatic, ii) economic (mainly in connection with population pressure or mining activities), and iii) cultural ideology. In this study we tested the above mentioned reasons in an interdisciplinary study on the beginning of pastoral activities in high altitudes in the central part of the Eastern Alps. This is conducted by palynological analyses of peat deposits situated in the vicinity of the timberline (1600 - 2400 m a.s.l.) combined with archaeological surveys. The investigated sites are located in traditional Alpine transhumance regions and aligned on a transect through the central part of the Eastern Alps. The studies reveal that grazing pressure is reflected since the Bronze Age, which is corroborated by archaeological findings in the vicinity of the investigated sites.

  7. BSM photon interaction for ALPS-II and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Doebrich, Babette

    2012-12-15

    High-intensity photon beams can provide for a viable probe for many particles of Standard Model extensions. This workshop contribution briefly reviews the status of the second stage of the Any Light Particle Search (ALPS-II) at DESY, an experiment of the light-shining-through-a-wall type, as well as an idea to test asymptotically safe quantum gravity in a photon-scattering experiment.

  8. ALPtraum. ALP production in proton beam dump experiments

    International Nuclear Information System (INIS)

    Doebrich, Babette; Jaeckel, Joerg

    2015-12-01

    With their high beam energy and intensity, existing and near-future proton beam dumps provide an excellent opportunity to search for new very weakly coupled particles in the MeV to GeV mass range. One particularly interesting example is a so-called axion-like particle (ALP), i.e. a pseudoscalar coupled to two photons. The challenge in proton beam dumps is to reliably calculate the production of the new particles from the interactions of two composite objects, the proton and the target atoms. In this work we argue that Primakoff production of ALPs proceeds in a momentum range where production rates and angular distributions can be determined to sufficient precision using simple electromagnetic form factors. Reanalysing past proton beam dump experiments for this production channel, we derive novel constraints on the parameter space for ALPs. We show that the NA62 experiment at CERN could probe unexplored parameter space by running in 'dump mode' for a few days and discuss opportunities for future experiments such as SHiP.

  9. TAFRO syndrome: current perspectives.

    Science.gov (United States)

    Sakashita, Kentaro; Murata, Kengo; Takamori, Mikio

    2018-01-01

    Multicentric Castleman's disease (MCD), a distinct subtype of Castleman's disease, is a rare, nonneoplastic, lymphoproliferative disorder. Patients with MCD present with systemic symptoms and multiple lymphadenopathy. Lymph node biopsy is necessary for the diagnosis of various histological MCD patterns including hyaline vascular, plasma cell, and mixed types. Human herpesvirus 8 (HHV8) infection was identified as an important etiology of MCD among immunocompromised patients such as those positive for human immunodeficiency virus. Although HHV8-negative MCD was reported in immunocompetent patients, the underlying etiology remains unknown. Several experts speculate that MCD in immunocompetent patients might be due to proinflammatory hypercytokinemia because of infection by a virus other than HHV8, inflammation, or neoplastic disease. In 2010, a distinct variant of HHV8-negative MCD reported in Japan was characterized by thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly (TAFRO). Recent case reports and a systematic review suggest that TAFRO syndrome might have a unique pathogenesis among HHV8-negative MCD variants. This review introduces TAFRO syndrome as a subtype of HHV8-negative MCD and offers an overview of the current perspectives on this syndrome.

  10. Epstein-Barr virus load in transplant patients: Early detection of post-transplant lymphoproliferative disorders.

    Science.gov (United States)

    Fellner, María Dolores; Durand, Karina A; Solernou, Veronica; Bosaleh, Andrea; Balbarrey, Ziomara; García de Dávila, María T; Rodríguez, Marcelo; Irazu, Lucía; Alonio, Lidia V; Picconi, María A

    2016-01-01

    High levels of circulating EBV load are used as a marker of post-transplant lymphoproliferative disorders (PTLD). There is no consensus regarding the threshold level indicative of an increase in peripheral EBV DNA. The aim of the study was to clinically validate a developed EBV quantification assay for early PTLD detection. Transversal study: paired peripheral blood mononuclear cells (PBMC), plasma and oropharyngeal lymphoid tissue (OLT) from children undergoing a solid organ transplant with (n=58) and without (n=47) PTLD. Retrospective follow-up: 71 paired PBMC and plasma from recipients with (n=6) and without (n=6) PTLD history. EBV load was determined by real-time PCR. The diagnostic ability to detect all PTLD (categories 1-4), advanced PTLD (categories 2-4) or neoplastic PTLD (categories 3 and 4) was estimated by analyzing the test performance at different cut-off values or with a load variation greater than 0.5log units. The higher diagnostic performance for identifying all, advanced or neoplastic PTLD, was achieved with cut-off values of 1.08; 1.60 and 2.47log EBVgEq/10(5) PBMC or 2.30; 2.60; 4.47loggEq/10(5) OLT cells, respectively. EBV DNA detection in plasma showed high specificity but low (all categories) or high (advanced/neoplastic categories) sensitivity for PTLD identification. Diagnostic performance was greater when: (1) a load variation in PBMC or plasma was identified; (2) combining the measure of EBV load in PBMC and plasma. The best diagnostic ability to identify early PTLD stages was achieved by monitoring EBV load in PBMC and plasma simultaneously; an algorithm was proposed. Copyright © 2016 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Usefullness of IGH/TCR PCR studies in lymphoproliferative disorders with inconclusive clonality by flow cytometry.

    Science.gov (United States)

    Ribera, Jordi; Zamora, Lurdes; Juncà, Jordi; Rodríguez, Inés; Marcé, Silvia; Cabezón, Marta; Millá, Fuensanta

    2013-07-25

    In up to 5-15% of studies of lymphoproliferative disorders (LPD) flow cytometry (FCM) or immunomorphologic methods cannot discriminate malignant from reactive processes. The aim of this work was to determine the usefulness of PCR for solving these diagnostic uncertainties. We analyzed IGH and TCRγ genes by PCR in 106 samples with inconclusive FCM results. A clonal result was registered in 36/106 studies, with a LPD being confirmed in 27 (75%) of these cases. Specifically, 9/9 IGH clonal and 16/25 TCRγ clonal results were finally diagnosed with LPD. Additionally, 2 clonal TCRγ samples with suspicion of undefined LPD were finally diagnosed with T LPD. Although polyclonal results were obtained in 47 of the cases studied (38 IGH and 9 TCRγ), hematologic neoplasms were diagnosed in 4/38 IGH polyclonal and in 1/9 TCRγ polyclonal studies. There were also 14 PCR polyclonal results (4 IGH, 10 TCRγ), albeit non-conclusive. Of these, 2/4 were eventually diagnosed with B-cell lymphoma and 3/10 with T-cell LPD. In 8 IGH samples the results of PCR techniques were non-informative but in 3/8 cases a B lymphoma was finally confirmed. We concluded that PCR is a useful technique to identify LPD when FCM is inconclusive. A PCR clonal B result is indicative of malignancy but IGH polyclonal and non-conclusive results do not exclude lymphoid neoplasms. Interpretation of T-cell clonality should be based on all the available clinical and analytical data. © 2013 Clinical Cytometry Society. Copyright © 2013 Clinical Cytometry Society.

  12. Isolated Post-Transplantation Lymphoproliferative Disease Involving the Breast and Axilla as Peripheral T-cell Lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Ji-Young [Department of Radiology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 150-950 (Korea, Republic of); Cha, Eun Suk; Lee, Jee Eun [Department of Radiology, Ewha Womans University School of Medicine, Seoul 158-710 (Korea, Republic of); Sung, Sun Hee [Department of Pathology, Ewha Womans University School of Medicine, Seoul 158-710 (Korea, Republic of)

    2013-07-01

    Post-transplantation lymphoproliferative disorders (PTLDs) are a heterogeneous group of diseases that represent serious complications following immunosuppressive therapy for solid organ or hematopoietic-cell recipients. In contrast to B-cell PTLD, T-cell PTLD is less frequent and is not usually associated with Epstein Barr Virus infection. Moreover, to our knowledge, isolated T-cell PTLD involving the breast is extremely rare and this condition has never been reported previously in the literature. Herein, we report a rare case of isolated T-cell PTLD of the breast that occurred after a patient had been treated for allogeneic peripheral blood stem cell transplantation due to acute myeloblastic leukemia.

  13. Isolated Post-Transplantation Lymphoproliferative Disease Involving the Breast and Axilla as Peripheral T-cell Lymphoma

    International Nuclear Information System (INIS)

    Hwang, Ji-Young; Cha, Eun Suk; Lee, Jee Eun; Sung, Sun Hee

    2013-01-01

    Post-transplantation lymphoproliferative disorders (PTLDs) are a heterogeneous group of diseases that represent serious complications following immunosuppressive therapy for solid organ or hematopoietic-cell recipients. In contrast to B-cell PTLD, T-cell PTLD is less frequent and is not usually associated with Epstein Barr Virus infection. Moreover, to our knowledge, isolated T-cell PTLD involving the breast is extremely rare and this condition has never been reported previously in the literature. Herein, we report a rare case of isolated T-cell PTLD of the breast that occurred after a patient had been treated for allogeneic peripheral blood stem cell transplantation due to acute myeloblastic leukemia

  14. Management of post-transplant lymphoproliferative disorder in adult solid organ transplant recipients - BCSH and BTS Guidelines.

    Science.gov (United States)

    Parker, Anne; Bowles, Kristin; Bradley, J Andrew; Emery, Vincent; Featherstone, Carrie; Gupte, Girish; Marcus, Robert; Parameshwar, Jayan; Ramsay, Alan; Newstead, Charles

    2010-06-01

    A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder in adult recipients of solid organ transplants. This review details the therapeutic options recommended including reduction in immunosuppression (RIS), transplant organ resection, radiotherapy and chemotherapy. Effective therapy should be instituted before progressive disease results in declining performance status and multi-organ dysfunction. The goal of treatment should be a durable complete remission with retention of transplanted organ function with minimal toxicity.

  15. Two rare cases of Epstein-Barr virus-associated lymphoproliferative disorders in inflammatory bowel disease patients on thiopurines and other immunosuppressive medications.

    Science.gov (United States)

    Subramaniam, K; Cherian, M; Jain, S; Latimer, M; Corbett, M; D'Rozario, J; Pavli, P

    2013-12-01

    The setting of chronic immunosuppression in inflammatory bowel disease (IBD) may promote the proliferation of Epstein-Barr virus-positive neoplastic clones. We report two rare cases of Epstein-Barr virus-associated lymphoproliferative disorder in IBD patients: one resembled lymphomatoid granulomatosis, and the other was a lymphoma resembling Hodgkin lymphoma. There are currently no guidelines for the prevention of lymphoproliferative disorder in IBD patients on immunosuppressive therapy. © 2013 The Authors; Internal Medicine Journal © 2013 Royal Australasian College of Physicians.

  16. Clinical Significance of Detection of Serum TBA and ALP in Diagnosis of Intrahepatic Cholestasis of Pregnancy

    International Nuclear Information System (INIS)

    Xiong Chuanzheng; Zhu Haibo; Deng jianping

    2009-01-01

    To investigate the clinical value of serum total bile acid (TBA) and alkaline phosphatase (ALP) in diagnosis of intahrpatic cholestasis of pregnancy (ICP), the serum levels of TBA, ALP and cholyglycine (CG) in 47 cases with intahrpatic cholestasis of pregnancy and 60 normal pregnant women were tested by biochemistry analysis and radioimmunoassay. The results showed that the serum levels of TBA and ALP in patients with intahrpatic cholestasis of pregnancy were significantly higher than that of normal pregnancy women. There was a positively correlation between TBA and ALP with CG. The combined determination of serum TBA and ALP could be useful in the diagnosis of intahrpatic cholestasis of pregnancy. Automatic biochemistry analysis of TBA and ALP is more simple and rapid than CG detected by radioimmunoassay,and it is suitable for clinical laboratory application. (authors)

  17. The XMAP215 Ortholog Alp14 Promotes Microtubule Nucleation in Fission Yeast.

    Science.gov (United States)

    Flor-Parra, Ignacio; Iglesias-Romero, Ana Belén; Chang, Fred

    2018-06-04

    The organization and number of microtubules (MTs) in a cell depend on the proper regulation of MT nucleation. Currently, the mechanism of nucleation is the most poorly understood aspect of MT dynamics. XMAP215/chTOG/Alp14/Stu2 proteins are MT polymerases that stimulate MT polymerization at MT plus ends by binding and releasing tubulin dimers. Although these proteins also localize to MT organizing centers and have nucleating activity in vitro, it is not yet clear whether these proteins participate in MT nucleation in vivo. Here, we demonstrate that in the fission yeast Schizosaccharomyces pombe, the XMAP215 ortholog Alp14 is critical for efficient MT nucleation in vivo. In multiple assays, loss of Alp14 function led to reduced nucleation rate and numbers of interphase MT bundles. Conversely, activation of Alp14 led to increased nucleation frequency. Alp14 associated with Mto1 and γ-tubulin complex components, and artificially targeting Alp14 to the γ-tubulin ring complexes (γ-TuRCs) stimulated nucleation. In imaging individual nucleation events, we found that Alp14 transiently associated with a γ-tubulin particle shortly before the appearance of a new MT. The transforming acidic coiled-coil (TACC) ortholog Alp7 mediated the localization of Alp14 at nucleation sites but not plus ends, and was required for efficient nucleation but not for MT polymerization. Our findings provide the strongest evidence to date that Alp14 serves as a critical MT nucleation factor in vivo. We suggest a model in which Alp14 associates with the γ-tubulin complex in an Alp7-dependent manner to facilitate the assembly or stabilization of the nascent MT. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. Prevention of EBV lymphoma development by oncolytic myxoma virus in a murine xenograft model of post-transplant lymphoproliferative disease

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Manbok, E-mail: manbok66@dankook.ac.kr [Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610 (United States); Rahman, Masmudur M. [Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610 (United States); Cogle, Christopher R. [Department of Hematology/Oncology, University of Florida, Gainesville, FL 32610 (United States); McFadden, Grant [Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610 (United States)

    2015-07-10

    Epstein–Barr virus (EBV) has been associated with a variety of epithelial and hematologic malignancies, including B-, T- and NK cell-lymphomas, Hodgkin's disease (HD), post-transplant lymphoproliferative diseases (LPDs), nasopharyngeal and gastric carcinomas, smooth muscle tumors, and HIV-associated lymphomas. Currently, treatment options for EBV-associated malignancies are limited. We have previously shown that myxoma virus specifically targets various human solid tumors and leukemia cells in a variety of animal models, while sparing normal human or murine tissues. Since transplant recipients of bone marrow or solid organs often develop EBV-associated post-transplant LPDs and lymphoma, myxoma virus may be of utility to prevent EBV-associated malignancies in immunocompromised transplant patients where treatment options are frequently limited. In this report, we demonstrate the safety and efficacy of myxoma virus purging as a prophylactic strategy for preventing post-transplant EBV-transformed human lymphomas, using a highly immunosuppressed mouse xenotransplantation model. This provides support for developing myxoma virus as a potential oncolytic therapy for preventing EBV-associated LPDs following transplantation of bone marrow or solid organ allografts. - Highlights: • Myxoma virus effectively infects and purges EBV lymphoma cells in vivo. • Oncolytic myxoma virus effectively eradicates oncogenic EBV tumorigenesis. • Ex vivo pre-treatment of myxoma virus can be effective as a preventive treatment modality for post-transplant lymphoproliferative diseases.

  19. Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single Center

    Directory of Open Access Journals (Sweden)

    Şule Mine Bakanay

    2014-03-01

    Full Text Available Three cases of Epstein-Barr virus (EBV-negative post-transplant lymphoproliferative disease that occurred 6 to 8 years after renal transplantation are reported. The patients respectively had gastric mucosa-associated lymphoid tissue lymphoma, gastric diffuse large B-cell lymphoma, and atypical Burkitt lymphoma. Absence of EBV in the tissue samples was demonstrated by both in situ hybridization for EBV early RNA and polymerase chain reaction for EBV DNA. Patients were treated with reduction in immunosuppression and combined chemotherapy plus an anti-CD20 monoclonal antibody, rituximab. Despite the reduction in immunosuppression, patients had stable renal functions without loss of graft functions. The patient with atypical Burkitt lymphoma had an abnormal karyotype, did not respond to treatment completely, and died due to disease progression. The other patients are still alive and in remission 5 and 3 years after diagnosis, respectively. EBV-negative post-transplant lymphoproliferative diseases are usually late-onset and are reported to have poor prognosis. Thus, reduction in immunosuppression is usually not sufficient for treatment and more aggressive approaches like rituximab with combined chemotherapy are required.

  20. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.

    Directory of Open Access Journals (Sweden)

    Shadmehr Demehri

    2008-05-01

    Full Text Available Epidermal keratinocytes form a highly organized stratified epithelium and sustain a competent barrier function together with dermal and hematopoietic cells. The Notch signaling pathway is a critical regulator of epidermal integrity. Here, we show that keratinocyte-specific deletion of total Notch signaling triggered a severe systemic B-lymphoproliferative disorder, causing death. RBP-j is the DNA binding partner of Notch, but both RBP-j-dependent and independent Notch signaling were necessary for proper epidermal differentiation and lipid deposition. Loss of both pathways caused a persistent defect in skin differentiation/barrier formation. In response, high levels of thymic stromal lymphopoietin (TSLP were released into systemic circulation by Notch-deficient keratinocytes that failed to differentiate, starting in utero. Exposure to high TSLP levels during neonatal hematopoiesis resulted in drastic expansion of peripheral pre- and immature B-lymphocytes, causing B-lymphoproliferative disorder associated with major organ infiltration and subsequent death, a previously unappreciated systemic effect of TSLP. These observations demonstrate that local skin perturbations can drive a lethal systemic disease and have important implications for a wide range of humoral and autoimmune diseases with skin manifestations.

  1. Prevention of EBV lymphoma development by oncolytic myxoma virus in a murine xenograft model of post-transplant lymphoproliferative disease

    International Nuclear Information System (INIS)

    Kim, Manbok; Rahman, Masmudur M.; Cogle, Christopher R.; McFadden, Grant

    2015-01-01

    Epstein–Barr virus (EBV) has been associated with a variety of epithelial and hematologic malignancies, including B-, T- and NK cell-lymphomas, Hodgkin's disease (HD), post-transplant lymphoproliferative diseases (LPDs), nasopharyngeal and gastric carcinomas, smooth muscle tumors, and HIV-associated lymphomas. Currently, treatment options for EBV-associated malignancies are limited. We have previously shown that myxoma virus specifically targets various human solid tumors and leukemia cells in a variety of animal models, while sparing normal human or murine tissues. Since transplant recipients of bone marrow or solid organs often develop EBV-associated post-transplant LPDs and lymphoma, myxoma virus may be of utility to prevent EBV-associated malignancies in immunocompromised transplant patients where treatment options are frequently limited. In this report, we demonstrate the safety and efficacy of myxoma virus purging as a prophylactic strategy for preventing post-transplant EBV-transformed human lymphomas, using a highly immunosuppressed mouse xenotransplantation model. This provides support for developing myxoma virus as a potential oncolytic therapy for preventing EBV-associated LPDs following transplantation of bone marrow or solid organ allografts. - Highlights: • Myxoma virus effectively infects and purges EBV lymphoma cells in vivo. • Oncolytic myxoma virus effectively eradicates oncogenic EBV tumorigenesis. • Ex vivo pre-treatment of myxoma virus can be effective as a preventive treatment modality for post-transplant lymphoproliferative diseases

  2. Snow chemistry of high altitude glaciers in the French Alps

    OpenAIRE

    MAUPETIT, FRANÇOIS; DELMAS, ROBERT J.

    2011-01-01

    Snow samples were collected as snowcores in the accumulation zone of four high altitude glaciers (2980–3540 m.a.s.l.) from each of the 4 highest mountain areas of the French Alps, during 3 consecutive years: 1989, 1990 and 1991. Sampling was performed in spring (∼ May), before the onset of late spring–summer percolation. The accumulated snow therefore reflects winter and spring conditions. A complementary sampling of fresh-snow was performed on an event basis, on one of the studied glaciers, ...

  3. New ALPS results on hidden-sector lightweights

    Energy Technology Data Exchange (ETDEWEB)

    Ehret, Klaus [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Frede, Maik [Laser Zentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover (Germany); Ghazaryan, Samvel [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Hildebrandt, Matthias [Laser Zentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover (Germany); Knabbe, Ernst-Axel [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Kracht, Dietmar [Laser Zentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover (Germany); Lindner, Axel, E-mail: axel.lindner@desy.d [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); List, Jenny [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Meier, Tobias [Max-Planck-Institute for Gravitational Physics, Albert-Einstein-Institute, Institut fuer Gravitationsphysik, Leibniz Universitaet, Hannover, Callinstrasse 38, D-30167 Hannover (Germany); Meyer, Niels; Notz, Dieter; Redondo, Javier; Ringwald, Andreas [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Wiedemann, Guenter [Hamburger Sternwarte, Gojenbergsweg 112, D-21029 Hamburg (Germany); Willke, Benno [Max-Planck-Institute for Gravitational Physics, Albert-Einstein-Institute, Institut fuer Gravitationsphysik, Leibniz Universitaet, Hannover, Callinstrasse 38, D-30167 Hannover (Germany)

    2010-05-31

    The ALPS Collaboration runs a 'Light Shining through a Wall' (LSW) experiment to search for photon oscillations into 'Weakly Interacting Sub-eV Particles' (WISPs) often predicted by extensions of the Standard Model. The experiment is set up around a superconducting HERA dipole magnet at the site of DESY. Due to several upgrades of the experiment we are able to place limits on the probability of photon-WISP-photon conversions of a fewx10{sup -25}. These limits result in today's most stringent laboratory constraints on the existence of low mass axion-like particles, hidden photons and minicharged particles.

  4. PHENOALP: a new project on phenology in the Western Alps

    Science.gov (United States)

    Cremonese, E.

    2009-04-01

    PHENOALP is a new EU co-funded Interreg Project under the operational programme for cross-border cooperation "Italy-France (Alps-ALCOTRA)" 2007 - 2013, aiming to get a better understanding of phenological changes in the Alps. The major goals of the project are: 1- The implementation of an observation network in the involved territories (i.e. the Aosta Valley and the Savoies in the Western Alps); 2- The definition of a common observation strategy and common protocols; 3- The involvement of local community members (e.g. through schools) in the observation activities as a way to increase the awareness on the issue of the effects of climate change. Project leader is the Environmental Protection Agency of Aosta Valley (ARPA Valle d'Aosta - IT) and the partners are the Research Center on High Altitude Ecosystem (CREA - FR), Mont Avic Regional Parc (IT), Bauges Massif Regional Natural Parc (FR) and the Protected Area Service of Aosta Valley (IT). Project activities are: 1. Pheno-plantes: definition of common observation protocols (e.g. field observation and webcams) of different alpine species (trees and herbaceous) and implementation of the observation network; analysis of the relations between climate and phenological events; application and evaluation of phenological models. 2. Pheno-detection: remote sensing of European larch and high elevation pastures with MODIS data; multitemporal analysis (2000-2011) of phenological variations in the Western Alps. 3. Pheno-flux: analysis of the relation between the seasonal and interannual variability of plant phenology and productivity, assessed measuring CO2 fluxes (eddy-covariance technique), radiometric indexes and phenological events at specific (European larch stand and alpine pastures) monitoring site. 4. Pheno-zoo: definition of common observation protocols for the phenology of animal taxa (birds, mammals, amphibians and insects) along altitudinal gradients; implementation of the observation network. 5. Inter

  5. New ALPS results on hidden-sector lightweights

    International Nuclear Information System (INIS)

    Ehret, Klaus; Ghazaryan, Samvel; Frede, Maik

    2010-01-01

    The ALPS collaboration runs a ''Light Shining through a Wall'' (LSW) experiment to search for photon oscillations into ''Weakly Interacting Sub-eV Particles'' (WISPs) often predicted by extensions of the Standard Model. The experiment is set up around a superconducting HERA dipole magnet at the site of DESY. Due to several upgrades of the experiment we are able to place limits on the probability of photon-WISP-photon conversions of a few x 10 -25 . These limits result in today's most stringent laboratory constraints on the existence of low mass axion-like particles, hidden photons and minicharged particles. (orig.)

  6. Crustal structure and active tectonics in the Eastern Alps

    DEFF Research Database (Denmark)

    Brückl, E.; Behm, M.; Decker, K.

    2010-01-01

    fragment (PA), was interpreted and a triple junction was inferred. The goal of this study has been to relate these deep crustal structures to active tectonics. We used elastic plate modeling to reconsider the Moho fragmentation. We interpret subduction of EU below AD and PA from north to south......During the last decade, a series of controlled source seismic experiments brought new insight into the crustal and lithospheric structure of the Eastern Alps and their adjacent tectonic provinces. A fragmentation of the lithosphere into three blocks, Europe (EU), Adria (AD), and the new Pannonian...

  7. Clinicopathologic Assessment of Ocular Adnexal Lymphoproliferative Lesions at a Tertiary Eye Hospital in Iran.

    Science.gov (United States)

    Asadi-Amoli, Fahimeh; Nozarian, Zohreh; Bonaki, Hirbod Nasiri; Mehrtash, Vahid; Entezari, Samaneh

    2016-01-01

    The most common type of ocular lymphoma is non-Hodgkin lymphoma (NHL), categorized into two groups: indolent (slow growing) and aggressive (rapid growing). Differentiating benign reactive lymphoid hyperplasia (RLH) from malignant ocular adnexal lymphoma (OAL) is challenging. Histopathology, immunohistochemistry (IHC) and ow cytometry have been used as diagnostic tools in such cases. In this retrospective case series, from 2002 to 2013 at Farabi Eye Center, 110 patients with ocular lymphoproliferative disease were enrolled. Prevalence, anatomical locations, mean age at diagnosis and the nal diagnosis of the disease with IHC were assessed. Comparison between previous pathologic diagnoses and results of IHC was made. Immunoglobulin light chains and B-cell and T-cell markers and other immuno-phenotyping markers including CD20, CD3, CD5, CD23, CD10, CYCLIND1 and BCL2 were evaluated to determine the most accurate diagnosis. The lymphomas were categorized based on revised European-American lymphoma (REAL) classi cation. Mean age±SD (years) of the patients was 55.6 ±19.3 and 61% were male. Patients with follicular lymphoma, large B-cell lymphoma or chronic lymphocytic leukemia/small cell lymphoma (CLL/SLL) tended to be older. Nine patients with previous diagnoses of low grade B-cell lymphoma were re-evaluated by IHC and the new diagnoses were as follows: extranodal marginal zone lymphoma(EMZL) (n=1), SLL(n=1), mantle cell lymphoma (MCL) (n=3), reactive lymphoid hyperplasia RLH (n=2). Two cases were excluded due to poor blocks. Flow cytometry reports in these seven patients revealed SLL with positive CD5 and CD23, MCL with positive CD5 and CyclinD1 and negative CD23, EMZL with negative CD5,CD23 and CD10. One RLH patient was negative for Kappa/Lambda and positive for CD3 and CD20 and the other was positive for all of the light chains, CD3 and CD20. Orbit (49.1%), conjunctiva (16.1%) and lacrimal glands (16.1%) were the most common sites of involvement. Accurate

  8. COMMUNITY DEVELOPMENT OF WHITEWATER SPORTS IN THE SOUTHERN ALPS

    Directory of Open Access Journals (Sweden)

    BERNARD MASSIERA

    2010-12-01

    Full Text Available Purpose: In order to better understand how certain sports tourism professionals have overcome the economic crisis, this paper focuses on how they have innovated on technical, managerial and marketing levels. Analyzing these strategies in the sector of “recreational white-water sports tourism” appears as a way to prospect.Design/methodology/approach: The offer of white-water sports tourism does not fall under tradition forms of organization known to work in the tourism sector. Since the end of the nineties its mode of development seems to have enabled this sector to avoid undergoing the economic crisis. The methodology, based on interviews withentrepreneurs in the sector of white-water sports tourism in the Southern Alps, addresses their managerial strategies and strategic modes of operation in the development of their businesses. The aim is to explore the managerial factors that have resulted in both economic and environmental sustainability. The concept of sustainable development is employed to understand how these entrepreneurial activities are embedded in the social, economic and natural environments of the Southern Alps valleys. Findings: The investigation shows that, rather than focusing on business strategy, professionals in this sector focus primarily on community relations. The supply of white-water sports tourism is presented in a lattice form which develops as a community. The modes of development of this sector, far from corresponding to standard business rationale, amount to a form of sustainable development which may explain the relative success of sport tourism in this period of crisis.

  9. Quantitative Epstein-Barr virus (EBV) serology in lung transplant recipients with primary EBV infection and/or post-transplant lymphoproliferative disease

    NARCIS (Netherlands)

    Verschuuren, E; van der Bij, W; de Boer, W; Timens, W; Middeldorp, J; The, TH

    The Epstein-Barr virus (EBV)-specific antibody response was studied in lung transplant patients to assess their value in the diagnosis and prognosis of post-transplant lymphoproliferative disease. Recently developed synthetic peptides representing Epstein-Barr nuclear antigen-1 (EBNA-1), diffuse

  10. Quantitative Epstein-Barr virus (EBV) serology in lung transplant recipients with primary EBV infection and/or post-transplant lymphoproliferative disease.

    NARCIS (Netherlands)

    Verschuuren, E; van der Bij, W; Boer, W.; Timens, W.; Middeldorp, J.M.; The, T.H.

    2003-01-01

    The Epstein-Barr virus (EBV)-specific antibody response was studied in lung transplant patients to assess their value in the diagnosis and prognosis of post-transplant lymphoproliferative disease. Recently developed synthetic peptides representing Epstein-Barr nuclear antigen-1 (EBNA-1), diffuse

  11. Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation

    NARCIS (Netherlands)

    J.W.J. van Esser (Joost); H.G.M. Niesters (Bert); B. van der Holt (Bronno); E. Meijer (Ellen); A.D.M.E. Osterhaus (Albert); J.W. Gratama (Jan-Willem); L.F. Verdonck (Leo); B. Löwenberg (Bob); J.J. Cornelissen (Jan)

    2002-01-01

    textabstractRecipients of a partially T-cell-depleted (TCD) allogeneic stem cell transplantation (allo-SCT) developing reactivation of Epstein-Barr virus (EBV) with quantified viral DNA levels exceeding 1000 genome equivalents/milliliter (geq/mL) are at high risk for EBV-lymphoproliferative disease

  12. A Girl with Autoimmune Cytopenias, Nonmalignant Lymphadenopathy, and Recurrent Infections

    Directory of Open Access Journals (Sweden)

    Marjolein A. C. Mattheij

    2012-01-01

    Full Text Available We describe a girl, now 9 years of age, with chronic idiopathic thrombocytopenic purpura, persistent nonmalignant lymphadenopathy, splenomegaly, recurrent infections, and autoimmune hemolytic anemia. Her symptoms partly fit the definitions of both autoimmune lymphoproliferative syndrome (ALPS and common variable immunodeficiency disorders (CVIDs. Genetic analysis showed no abnormalities in the ALPS-genes FAS, FASLG, and CASP10. The CVID-associated TACI gene showed a homozygous polymorphism (Pro251Leu, which is found also in healthy controls.

  13. A strange case of Evans syndrome

    Directory of Open Access Journals (Sweden)

    Manuel Monti

    2013-12-01

    Full Text Available Evans syndrome is a rare autoimmune disease presenting hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. It can have an extremely serious disease course and, in rare cases, this can even be life-threatening. First-line treatment consists of steroids and/or immunoglobulin. Further therapy with rituximab, vincristine, cyclophosphamide and other immunosuppressive drugs can be considered in unresponsive patients. We report a case of Evans syndrome in a 54-year old woman admitted to the Emergency Department (ED for asthenia. Etiopathogenic, clinical, therapeutic and evolutive aspects are discussed. In contrast to many cases described in the literature, our patient had a satisfactory response to corticoids. We also discuss how to make a specific diagnosis, even in a suburban ED with limited resources, in order to admit patients to the appropriate hospital department and allow the correct therapy to be started as early as possible.

  14. Medical ethnobotany of the Albanian Alps in Kosovo.

    Science.gov (United States)

    Mustafa, Behxhet; Hajdari, Avni; Krasniqi, Feriz; Hoxha, Esat; Ademi, Hatixhe; Quave, Cassandra L; Pieroni, Andrea

    2012-01-28

    Ethnobotanical studies are crucial in South-Eastern Europe for fostering local development and also for investigating the dynamics of Traditional Environmental Knowledge (TEK) related to plants in one of the most crucial European hotspots for biocultural diversity. The current medico-ethnobotanical survey was conducted in rural alpine communities in Kosovo. The aims of the study were twofold: 1) to document the state of TEK of medicinal plants in these communities; 2) to compare these findings with that of similar field studies previously conducted among local populations inhabiting the Montenegrin and Albanian side of the same Alpine range. Field research was conducted in 36 villages on the Kosovar side of the Albanian Alps. Snowball sampling techniques were used to recruit 91 elderly informants (≥ 50 years-old) for participation in semi-structured interviews and structured surveys regarding the use of the local flora for medicinal and food purposes. Standard ethnobotanical methods were employed and prior informed consent was obtained for all study participants. The uses of 98 plants species belonging to 39 families were recorded; the most quoted botanical families were Rosaceae, Asteraceae, and Lamiaceae. Mainly decoctions and infusions were quoted as folk medicinal preparations and the most common uses referred to gastrointestinal and respiratory disorders, as well as illnesses of the uro-genital system. Among the most uncommon medicinal taxa quoted by the informants, Carduus nutans L., Echinops bannaticus Rochel ex Schrad., and Orlaya grandiflora Hoffm. may merit phytochemical and phytopharmacological investigations.Comparison of the data with other ethnobotanical field studies recently conducted on the Albanian and Montenegrin sides of the same Alps has shown a remarkable link between the medical ethnobotany of Montenegrin and Kosovar side of the Albanian Alps. Moreover, folk uses of the most quoted wild medicinal taxa recorded in Kosovo often include those

  15. Medical ethnobotany of the Albanian Alps in Kosovo

    Directory of Open Access Journals (Sweden)

    Mustafa Behxhet

    2012-01-01

    Full Text Available Abstract Background Ethnobotanical studies are crucial in South-Eastern Europe for fostering local development and also for investigating the dynamics of Traditional Environmental Knowledge (TEK related to plants in one of the most crucial European hotspots for biocultural diversity. The current medico-ethnobotanical survey was conducted in rural alpine communities in Kosovo. The aims of the study were twofold: 1 to document the state of TEK of medicinal plants in these communities; 2 to compare these findings with that of similar field studies previously conducted among local populations inhabiting the Montenegrin and Albanian side of the same Alpine range. Methods Field research was conducted in 36 villages on the Kosovar side of the Albanian Alps. Snowball sampling techniques were used to recruit 91 elderly informants (≥ 50 years-old for participation in semi-structured interviews and structured surveys regarding the use of the local flora for medicinal and food purposes. Standard ethnobotanical methods were employed and prior informed consent was obtained for all study participants. Results and Conclusion The uses of 98 plants species belonging to 39 families were recorded; the most quoted botanical families were Rosaceae, Asteraceae, and Lamiaceae. Mainly decoctions and infusions were quoted as folk medicinal preparations and the most common uses referred to gastrointestinal and respiratory disorders, as well as illnesses of the uro-genital system. Among the most uncommon medicinal taxa quoted by the informants, Carduus nutans L., Echinops bannaticus Rochel ex Schrad., and Orlaya grandiflora Hoffm. may merit phytochemical and phytopharmacological investigations. Comparison of the data with other ethnobotanical field studies recently conducted on the Albanian and Montenegrin sides of the same Alps has shown a remarkable link between the medical ethnobotany of Montenegrin and Kosovar side of the Albanian Alps. Moreover, folk uses of the

  16. Cultures and politics in the present-day Alps

    Directory of Open Access Journals (Sweden)

    Bernard Debarbieux

    2009-03-01

    Full Text Available Plus que jamais, l’espace alpin est marqué par le déploiement de flux toujours plus variés, toujours plus puissants, et symétriquement par la multiplication d’initiatives destinées à conforter ou à régénérer l’idée de localité. Quelles spatialités et quelles territorialités travaillent les populations alpines aujourd’hui ? Quelles sont les figures contemporaines de la circulation et des flux, et les figures complémentaires de l’ancrage et de la refondation territoriale ? Voici les questions que cet essai se propose de développer. Ce texte reprend le contenu d’une conférence donnée dans le cadre de la célébration du centenaire de l’Institut de Géographie Alpine. Cette conférence, comme les autres données à cette occasion, avait adopté une forme libre dressant un bilan et des perspectives de la situation alpine. La trace écrite adoptée ici prend alors logiquement la forme d’un essai.More than ever before, the Alps are affected by increasingly varied and powerful flows and equally by the multiplication of initiatives designed to strengthen or regenerate the idea of “locality” (place. What spatialities and what territorialities activate the populations of the Alps today? What are the contemporary figures relating to circulation and flows and the complementary figures concerning spatial “anchoring” or fixity and new territorial foundations? These are the questions that this essay, proposes to develop. This text takes another look at the subject of a lecture given as part of celebrations to mark the centenary of the Institut de Géographie Alpine. This lecture, like the others given on this occasion, adopted a free format, presenting a report on the current situation in the Alps and prospects for the future. The written format adopted here logically takes the form of an essay. Readers looking for detailed illustrations and references are referred to three scientific articles published by the same

  17. 21st Century Climate Change in the European Alps

    Science.gov (United States)

    Gobiet, Andreas; Kotlarski, Sven; Stoffel, Markus; Heinrich, Georg; Rajczak, Jan; Beniston, Martin

    2014-05-01

    The Alps are particularly sensitive to global warming and warmed twice as much as the global average in the recent past. In addition, the Alps and its surroundings are a densly populated areas where society is affected by climate change in many ways, which calls for reliable estimates of future climate change. However, the complex Alpine region poses considerable challenges to climate models, which translate to uncertainties in future climate projections. Against this background, the present study reviews the state-of-knowledge about 21st century climate change in the Alps based on existing literature and additional analyses. It will be demonstrated that considerable and accelerating changes are not only to be expected with regard to temperature, but also precipitation, global radiation, relative humidity, and closely related impacts like floods, droughts, snow cover, and natural hazards will be effected by global warming. Under the A1B emission scenario, about 0.25 °C warming per decade until the mid of the 21st century and accelerated 0.36 °C warming per decade in the second half of the century is expected. Warming will most probably be associated with changes in the seasonality of precipitation, global radiation, and relative humidity. More intense precipitation extremes and flooding potential are particularly expected in the colder part of the year. The conditions of currently record breaking warm or hot winter or summer seasons, respectively, may become normal at the end of the 21st century, and there is indication for droughts to become more severe in the future. Snow cover is expected to drastically decrease below 1500 - 2000 m and natural hazards related to glacier and permafrost retreat are expected to become more frequent. Such changes in climatic variables and related quantities will have considerable impact on ecosystems and society and will challenge their adaptive capabilities. Acknowledgements: This study has been initiated and is partly funded by

  18. Hodgkin's disease as unusual presentation of post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for malignant glioma

    Directory of Open Access Journals (Sweden)

    Scelsi Mario

    2005-08-01

    Full Text Available Abstract Background Post-transplant lymphoproliferative disorder (PTLD is a complication of solid organ and allogeneic hematopoietic stem cell transplantation (HSCT; following autologous HSCT only rare cases of PTLD have been reported. Here, a case of Hodgkin's disease (HD, as unusual presentation of PTLD after autologous HSCT for malignant glioma is described. Case presentation 60-years old man affected by cerebral anaplastic astrocytoma underwent subtotal neurosurgical excision and subsequent high-dose chemotherapy followed by autologous HSCT. During the post HSCT course, cranial irradiation and corticosteroids were administered as completion of therapeutic program. At day +105 after HSCT, the patient developed HD, nodular sclerosis type, with polymorphic HD-like skin infiltration. Conclusion The clinical and pathological findings were consistent with the diagnosis of PTLD.

  19. Hairy B-cell lymphoproliferative disorder and its differential diagnosis: a case with long-term follow-up

    Directory of Open Access Journals (Sweden)

    Kensuke Matsuda

    2017-09-01

    Full Text Available Hairy B-cell lymphoproliferative disorder (HBLD is one of chronic polyclonal B-cell lymphocytosis. We report a 47-year-old female Japanese patient diagnosed as having HBLD based on lymphocytosis with hairy cell appearance and characteristic phenotypes including CD11c+, and without B-cell monoclonalities. She was a non-smoker, and possessed HLA-DR4. She has been closely followed up without treatment and lymphoma development for over five years. Although this disease is quite rare and has been reported, to our knowledge, in only 13 Japanese cases, an accurate diagnosis, particularly differential diagnosis from persistent polyclonal B-cell lymphocytosis or hairy cell leukemia-Japanese variant is essential for the prevention of unnecessary treatments.

  20. New ALPS results on hidden-sector lightweights

    Energy Technology Data Exchange (ETDEWEB)

    Ehret, Klaus; Ghazaryan, Samvel [Deutsches Elektronen-Synchrotron DESY, Hamburg (Germany); Frede, Maik [Laser Zentrum Hannover e.V. (DE)] (and others)

    2010-04-08

    The ALPS collaboration runs a ''Light Shining through a Wall'' (LSW) experiment to search for photon oscillations into ''Weakly Interacting Sub-eV Particles'' (WISPs) often predicted by extensions of the Standard Model. The experiment is set up around a superconducting HERA dipole magnet at the site of DESY. Due to several upgrades of the experiment we are able to place limits on the probability of photon-WISP-photon conversions of a few x 10{sup -25}. These limits result in today's most stringent laboratory constraints on the existence of low mass axion-like particles, hidden photons and minicharged particles. (orig.)

  1. Morphological expression of active tectonics in the Southern Alps

    Science.gov (United States)

    Robl, Jörg; Heberer, Bianca; Neubauer, Franz; Hergarten, Stefan

    2015-04-01

    Evolving drainage pattern and corresponding metrics of the channels (e.g. normalized steepness index) are sensitive indicators for tectonic or climatic events punctuating the evolution of mountain belts and their associated foreland basins. The analysis of drainage systems and their characteristic properties represents a well-established approach to constrain the impact of tectonic and climatic drivers on mountainous landscapes in the recent past. The Southern Alps (SA) are one of the seismically most active zones in the periphery of northern Adria. Recent deformation is caused by the ongoing convergence of the Adriatic and European plate and is recorded by numerous earthquakes in the domain of the SA. Deformation in the SA is characterized by back-thrusting causing crustal thickening and should therefore result in uplift and topography formation. The vertical velocity field determined by GPS-data clearly indicates a belt of significant uplift in the south South alpine indenter between Lake Garda in the west and the Triglav in the east and strong subsidence of the foreland basin surrounding the Mediterranean Sea near Venice, although subsidence is often related to ongoing subduction of the Adriatic microplate underneath Appennines. Despite of these short term time series, timing, rates and drivers of alpine landscape evolution are not well constrained and the linkage between crustal deformation and topographic evolution of this highly active alpine segment remains unclear for the following reasons: (1) The eastern Southern Alps were heavily overprinted by the Pleistocene glaciations and tectonic signals in the alpine landscape are blurred. Only the transition zone to the southern foreland basin remained unaffected and allows an analysis of a glacially undisturbed topography. (2) The major part of this domain is covered by lithology (carbonatic rocks) which is unsuitable for low temperature geochronology and cosmogenic isotope dating so that exhumation and erosion

  2. Sjogren syndrome complicated by mucosa-associated lymphoid tissue lymphoma and lymphocytic interstitial pneumonia

    Directory of Open Access Journals (Sweden)

    Fatma eAhmed

    2015-08-01

    Full Text Available Sjogren Syndrome (SS is an autoimmune disease with exocrine glands dysfunction and multiorgan involvement. It is associated with increased risk of lymphoproliferative disorders, especially B-cell marginal zone lymphoma. While the role of F-18 Flurodoxyglucose position emission tomography/CT (F-18 FDG PET/CT for evaluation of lymphoma has been established, its use in patients with a chronic history of SS to evaluate for possible lymphoproliferative disorders or multiorgan involvement is limited. We present a case of chronic SS in which F-18 FDG PET/CT demonstrated FDG avid intraparotid and cervical lymph nodes pathologically proven to be Mucosa-associated lymphoid tissue (MALT lymphoma. In addition, the patient had bibasilar cystic changes consistent with lymphocytic interstitial pneumonia (LIP.

  3. Intestinal transplantation for children with short bowel syndrome.

    Science.gov (United States)

    Reyes, J

    2001-05-01

    Intestinal transplantation has emerged as a feasible alternative in the treatment of children with short gut syndrome. The challenges in the management of these patients include maintaining a tight balance between the degree of immunosuppression necessary to prevent graft-versus-host disease and rejection. At the same time, this amount of immunosuppression is associated with a high risk for lymphoproliferative disorders and intestinal-derived sepsis. Current 3-year patient and graft survival rates are 55% and 50%, respectively. The indications, morbidity, and timing for referral are discussed.

  4. Recent advances in the risk factors, diagnosis and management of Epstein-Barr virus post-transplant lymphoproliferative disease.

    Science.gov (United States)

    Aguayo-Hiraldo, Paibel; Arasaratnam, Reuben; Rouce, Rayne H

    Fifty years after the first reports of Epstein-Barr virus (EBV)-associated endemic Burkitt's lymphoma, EBV has emerged as the third most prevalent oncogenic virus worldwide. EBV infection is associated with various malignancies including Hodgkin and non-Hodgkin lymphoma, NK/T-cell lymphoma and nasopharyngeal carcinoma. Despite the highly specific immunologic control in the immunocompetent host, EBV can cause severe complications in the immunocompromised host (namely, post-transplant lymphoproliferative disease). This is particularly a problem in patients with delayed immune reconstitution post-hematopoietic stem cell transplant or solid organ transplant. Despite advances in diagnostic techniques and treatment algorithms allowing earlier identification and treatment of patients at highest risk, mortality rates remain as high as 90% if not treated early. The cornerstones of treatment include reduction in immunosuppression and in vivo B cell depletion with an anti-CD20 monoclonal antibody. However, these treatment modalities are not always feasible due to graft rejection, emergence of graft vs. host disease, and toxicity. Newer treatment modalities include the use of adoptive T cell therapy, which has shown promising results in various EBV-related malignancies. In this article we will review recent advances in risk factors, diagnosis and management of EBV-associated malignancies, particularly post-transplant lymphoproliferative disease. We will also discuss new and innovative treatment options including adoptive T cell therapy as well as management of special situations such as chronic active EBV and EBV-associated hemophagocytic lymphohistiocytosis. Copyright © 2015 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  5. Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice

    Directory of Open Access Journals (Sweden)

    Veronica S. Gil

    2016-12-01

    Full Text Available Histone deacetylase 9 (HDAC9 is expressed in B cells, and its overexpression has been observed in B-lymphoproliferative disorders, including B-cell non-Hodgkin lymphoma (B-NHL. We examined HDAC9 protein expression and copy number alterations in primary B-NHL samples, identifying high HDAC9 expression among various lymphoma entities and HDAC9 copy number gains in 50% of diffuse large B-cell lymphoma (DLBCL. To study the role of HDAC9 in lymphomagenesis, we generated a genetically engineered mouse (GEM model that constitutively expressed an HDAC9 transgene throughout B-cell development under the control of the immunoglobulin heavy chain (IgH enhancer (Eμ. Here, we report that the Eμ-HDAC9 GEM model develops splenic marginal zone lymphoma and lymphoproliferative disease (LPD with progression towards aggressive DLBCL, with gene expression profiling supporting a germinal center cell origin, as is also seen in human B-NHL tumors. Analysis of Eμ-HDAC9 tumors suggested that HDAC9 might contribute to lymphomagenesis by altering pathways involved in growth and survival, as well as modulating BCL6 activity and p53 tumor suppressor function. Epigenetic modifications play an important role in the germinal center response, and deregulation of the B-cell epigenome as a consequence of mutations and other genomic aberrations are being increasingly recognized as important steps in the pathogenesis of a variety of B-cell lymphomas. A thorough mechanistic understanding of these alterations will inform the use of targeted therapies for these malignancies. These findings strongly suggest a role for HDAC9 in B-NHL and establish a novel GEM model for the study of lymphomagenesis and, potentially, preclinical testing of therapeutic approaches based on histone deacetylase inhibitors.

  6. Effectiveness of cyclosporine and mycophenolate mofetil in a child with refractory evans syndrome

    Directory of Open Access Journals (Sweden)

    Piero Farruggia

    2011-05-01

    Full Text Available Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. Its course can be extremely serious and, rarely, even life-threatening; thus it represents a excellent treatment challenge for the pediatric hematologist. First line treatment consists of steroids and/or immunoglobulin; further therapy with rituximab, vincristine, cyclophosphamide and other immunosuppressive drugs can be considered in unresponsive patients. We describe a baby with refractory Evans Syndrome that was cured by prolonged administration of mycophenolate mofetil and remained disease-free for 4 years after the discontinuation of treatment.

  7. The quest for an intermediate-scale accidental axion and further ALPs

    Energy Technology Data Exchange (ETDEWEB)

    Dias, A.G.; Nishi, C.C. [Univ. Federal do ABC - UFABC, Sao Paulo (Brazil); Machado, A.C.B. [Teorica-Univ. Estadual Paulista, Sao Paulo (Brazil). Instituto de Fisica; Ringwald, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Vaudrevange, P. [Technische Univ. Muenchen, Garching (Germany). Excellence Cluster Universe

    2014-03-15

    The recent detection of the cosmic microwave background polarimeter experiment BICEP2 of tensor fluctuations in the B-mode power spectrum basically excludes all plausible axion models where its decay constant is above 10{sup 13} GeV. Moreover, there are strong theoretical, astrophysical, and cosmological motivations for models involving, in addition to the axion, also axion-like particles (ALPs), with decay constants in the intermediate scale range, between 10{sup 9} GeV and 10{sup 13} GeV. Here, we present a general analysis of models with an axion and further ALPs and derive bounds on the relative size of the axion and ALP photon (and electron) coupling. We discuss what we can learn from measurements of the axion and ALP photon couplings about the fundamental parameters of the underlying ultraviolet completion of the theory. For the latter we consider extensions of the Standard Model in which the axion and the ALP(s) appear as pseudo Nambu-Goldstone bosons from the breaking of global chiral U(1) (Peccei-Quinn (PQ)) symmetries, occuring accidentally as low energy remnants from exact discrete symmetries. In such models, the axion and the further ALP are protected from disastrous explicit symmetry breaking effects due to Planck-scale suppressed operators. The scenarios considered exploit heavy right handed neutrinos getting their mass via PQ symmetry breaking and thus explain the small mass of the active neutrinos via a seesaw relation between the electroweak and an intermediate PQ symmetry breaking scale. We show some models that can accommodate simultaneously an axion dark matter candidate, an ALP explaining the anomalous transparency of the universe for γ-rays, and an ALP explaining the recently reported 3.55 keV gamma line from galaxies and clusters of galaxies, if the respective decay constants are of intermediate scale.

  8. The quest for an intermediate-scale accidental axion and further ALPs

    International Nuclear Information System (INIS)

    Dias, A.G.; Nishi, C.C.; Machado, A.C.B.; Vaudrevange, P.

    2014-03-01

    The recent detection of the cosmic microwave background polarimeter experiment BICEP2 of tensor fluctuations in the B-mode power spectrum basically excludes all plausible axion models where its decay constant is above 10 13 GeV. Moreover, there are strong theoretical, astrophysical, and cosmological motivations for models involving, in addition to the axion, also axion-like particles (ALPs), with decay constants in the intermediate scale range, between 10 9 GeV and 10 13 GeV. Here, we present a general analysis of models with an axion and further ALPs and derive bounds on the relative size of the axion and ALP photon (and electron) coupling. We discuss what we can learn from measurements of the axion and ALP photon couplings about the fundamental parameters of the underlying ultraviolet completion of the theory. For the latter we consider extensions of the Standard Model in which the axion and the ALP(s) appear as pseudo Nambu-Goldstone bosons from the breaking of global chiral U(1) (Peccei-Quinn (PQ)) symmetries, occuring accidentally as low energy remnants from exact discrete symmetries. In such models, the axion and the further ALP are protected from disastrous explicit symmetry breaking effects due to Planck-scale suppressed operators. The scenarios considered exploit heavy right handed neutrinos getting their mass via PQ symmetry breaking and thus explain the small mass of the active neutrinos via a seesaw relation between the electroweak and an intermediate PQ symmetry breaking scale. We show some models that can accommodate simultaneously an axion dark matter candidate, an ALP explaining the anomalous transparency of the universe for γ-rays, and an ALP explaining the recently reported 3.55 keV gamma line from galaxies and clusters of galaxies, if the respective decay constants are of intermediate scale.

  9. Topographic evolution of a continental indenter: The eastern Southern Alps

    Science.gov (United States)

    Robl, Jörg; Heberer, Bianca; Prasicek, Günther; Neubauer, Franz; Hergarten, Stefan

    2017-04-01

    The topographic evolution of the eastern Southern Alps (ESA) is controlled by the Late Oligocene - Early Miocene indentation of the Adriatic microplate into an overthickened orogenic wedge emplaced on top of the European plate. Rivers follow topographic gradients that evolve during continental collision and in turn incise into bedrock counteracting the formation of topography. In principle, erosional surface processes tend to establish a topographic steady state so that an interpretation of topographic metrics in terms of the latest tectonic history should be straightforward. However, a series of complications impede deciphering the topographic record of the ESA. The Pleistocene glaciations locally excavated alpine valleys and perturbed fluvial drainages. The Late Miocene desiccation of the Mediterranean Sea and the uplift of the northern Molasse Basin led to significant base level changes in the far field of the ESA and the Eastern Alps (EA), respectively. Among this multitude of mechanisms, the processes that dominate the current topographic evolution of the ESA and the ESA-EA drainage divide have not been identified and a number of questions regarding the interaction of crustal deformation, erosion and climate in shaping the present-day topography remain. We demonstrate the expected topographic effects of each mechanism in a 1-dimensional model and compare them with observed channel metrics. Modern uplift rates are largely consistent with long-term exhumation in the ESA and with variations in the normalized steepness index (ksn) indicating a stable uplift and erosion pattern since Miocene times. We find that ksn increases with uplift rate and declines from the indenter tip in the northwest to the foreland basin in the southeast. The number and magnitude of knickpoints and the distortion in longitudinal channel profiles similarly decrease towards the east. Most knickpoints probably evolved during Pleistocene glaciation cycles, but may represent the incrementally

  10. Spatial and temporal patterns of wildfires in the Northern Alps

    Science.gov (United States)

    Heel, Michael; Sass, Oliver; Friedmann, Arne; Wetzel, Karl-Friedrich

    2010-05-01

    Wildfires in the northern Alps are rare compared to e.g. the Mediterranean region. However, fires occurring on the dry, south-exposed slopes of the inner-alpine valleys can constitute a significant disturbance of the ecosystems in the sub-alpine belt. We reconstructed the younger regional wildfire history (last few centuries) of a part of the the Northern Limestone Alps using chronicles, forestry and fire brigade records as well as historical pictures (postcards, aerial photos etc.), local names and interviews with local people. The long-term fire frequency was investigated using mire drillings, charcoal in soils and dendrochronology. In the surrounding of the Karwendel, Wetterstein and Mieminger Mountains we have identified c. 400 forest fires to date. The earliest detected fire dates to more than 2900 years; the largest one (in 1705) affected an area of several thousand hectares. Approximately 90% of the fires are man-made (negligence, arson, railway) which explains the concentration on the south-exposed slopes of the densely populated Inn valley. Most of the larger fires take place in the altitudinal belt between 1400 and 1900 m a.s.l.; apart from very few exceptions, they are restricted to southerly orientations. Locally, mean recurrence intervals of 200-300 years occur which is similar to e.g. boreal forests in Canada. We observed a strong seasonality with 40% of the fires occurring in spring and 30% in summer. There is a weak correlation with the weather conditions in the one or two weeks before the fire with dry periods promoting wildfire ignition and burnt area size; however, there are many exceptions from the rule. The 1940ies stands out for more than twice as much fires than in all other decades which is both due to climatic and anthropogenic causes. Today, there is an apparent trend towards more frequent and smaller fires. The frequency is biased by the multitude of available documentation today (e.g. websites of fire brigades), while the decreasing size

  11. Regulation of the Synthesis of the Angucyclinone Antibiotic Alpomycin in Streptomyces ambofaciens by the Autoregulator Receptor AlpZ and Its Specific Ligand▿

    Science.gov (United States)

    Bunet, Robert; Mendes, Marta V.; Rouhier, Nicolas; Pang, Xiuhua; Hotel, Laurence; Leblond, Pierre; Aigle, Bertrand

    2008-01-01

    Streptomyces ambofaciens produces an orange pigment and the antibiotic alpomycin, both of which are products of a type II polyketide synthase gene cluster identified in each of the terminal inverted repeats of the linear chromosome. Five regulatory genes encoding Streptomyces antibiotic regulatory proteins (alpV, previously shown to be an essential activator gene; alpT; and alpU) and TetR family receptors (alpZ and alpW) were detected in this cluster. Here, we demonstrate that AlpZ, which shows high similarity to γ-butyrolactone receptors, is at the top of a pathway-specific regulatory hierarchy that prevents synthesis of the alp polyketide products. Deletion of the two copies of alpZ resulted in the precocious production of both alpomycin and the orange pigment, suggesting a repressor role for AlpZ. Consistent with this, expression of the five alp-located regulatory genes and of two representative biosynthetic structural genes (alpA and alpR) was induced earlier in the alpZ deletion strain. Furthermore, recombinant AlpZ was shown to bind to specific DNA sequences within the promoter regions of alpZ, alpV, and alpXW, suggesting direct transcriptional control of these genes by AlpZ. Analysis of solvent extracts of S. ambofaciens cultures identified the existence of a factor which induces precocious production of alpomycin and pigment in the wild-type strain and which can disrupt the binding of AlpZ to its DNA targets. This activity is reminiscent of γ-butyrolactone-type molecules. However, the AlpZ-interacting molecule(s) was shown to be resistant to an alkali treatment capable of inactivating γ-butyrolactones, suggesting that the AlpZ ligand(s) does not possess a lactone functional group. PMID:18296523

  12. Regulation of the synthesis of the angucyclinone antibiotic alpomycin in Streptomyces ambofaciens by the autoregulator receptor AlpZ and its specific ligand.

    Science.gov (United States)

    Bunet, Robert; Mendes, Marta V; Rouhier, Nicolas; Pang, Xiuhua; Hotel, Laurence; Leblond, Pierre; Aigle, Bertrand

    2008-05-01

    Streptomyces ambofaciens produces an orange pigment and the antibiotic alpomycin, both of which are products of a type II polyketide synthase gene cluster identified in each of the terminal inverted repeats of the linear chromosome. Five regulatory genes encoding Streptomyces antibiotic regulatory proteins (alpV, previously shown to be an essential activator gene; alpT; and alpU) and TetR family receptors (alpZ and alpW) were detected in this cluster. Here, we demonstrate that AlpZ, which shows high similarity to gamma-butyrolactone receptors, is at the top of a pathway-specific regulatory hierarchy that prevents synthesis of the alp polyketide products. Deletion of the two copies of alpZ resulted in the precocious production of both alpomycin and the orange pigment, suggesting a repressor role for AlpZ. Consistent with this, expression of the five alp-located regulatory genes and of two representative biosynthetic structural genes (alpA and alpR) was induced earlier in the alpZ deletion strain. Furthermore, recombinant AlpZ was shown to bind to specific DNA sequences within the promoter regions of alpZ, alpV, and alpXW, suggesting direct transcriptional control of these genes by AlpZ. Analysis of solvent extracts of S. ambofaciens cultures identified the existence of a factor which induces precocious production of alpomycin and pigment in the wild-type strain and which can disrupt the binding of AlpZ to its DNA targets. This activity is reminiscent of gamma-butyrolactone-type molecules. However, the AlpZ-interacting molecule(s) was shown to be resistant to an alkali treatment capable of inactivating gamma-butyrolactones, suggesting that the AlpZ ligand(s) does not possess a lactone functional group.

  13. Preventing acute rejection, Epstein-Barr virus infection, and posttransplant lymphoproliferative disorders after kidney transplantation: Use of aciclovir and mycophenolate mofetil in a steroid-free immunosuppressive protocol

    DEFF Research Database (Denmark)

    Birkeland, S.A.; Andersen, H.K.; Hamilton-Dutoit, Stephen Jacques

    1999-01-01

    Background: A widely held view is that any increase in the potency of an immunosuppressive agent will lead to an increase in infection and malignancy, such as life-threatening Epstein-Barr virus (EBV) induced posttransplant lymphoproliferative disorders (PTLD), We tested this paradigm by studying...... or reactivated EBV infection (PREBV) was correlated to acute rejection (treated with OKT3; Pdisease is included); (2) aciclovir protected against PREBV (P

  14. La recherche sur les montagnes entre Alpes et monde : regards rétrospectifs

    Directory of Open Access Journals (Sweden)

    Thomas Scheurer

    2009-03-01

    Full Text Available L’expression « recherche alpine », on le constatera au fil de ce volume, reste bien incertaine. La première lecture suscite une interrogation : s’agit-il d’une recherche menée sur les Alpes ou dans les Alpes ? Ou pour les Alpes ? C’est-à-dire répondant à une demande émanant d’« acteurs alpins » ? On observera aisément que la recherche sur des terrains alpins et selon des thématiques et des questionnements soulevés par les sociétés alpines est menée préférentiellement au sein des Alpes. Il n’y...

  15. Bone scintigraphy, plasma ALP, TAP and PAP in patients with prostatic cancer

    International Nuclear Information System (INIS)

    Imamura, Akihiko; Hoshi, Hiroaki; Jinnouchi, Seishi; Samejima, Masahiko; Watanabe, Katsushi

    1988-01-01

    This study assessed the ability of bone scintigraphy, alkaline phosphatase (ALP), total acid phosphatase (TAP), and prostatic acid phosphatase (PAP) to diagnose bone metastasis in a series of 62 patients with histologically proven prostatic cancer. Abnormal uptake was seen on the bone scan in 49 patients (79 %). A final diagnosis of bone metastasis was made in 40 patients (65 %). The sensitivity and specificity were 100 % and 59 %, respectively, for bone scintigraphy; 50 % and 96 % for ALP; 65 % and 82 % for TAP; and 73 % and 77 % for PAP. For 40 patients with bone metastasis, all of the ALP, TAP, and PAP were positive in 17 patients (43 %) and negative in 8 patients (20 %). Higher levels of ALP, TAP, and PAP tended to be associated with more extensive bone metastasis. Although serological examination showed lower sensitivity than bone scintigraphy in the diagnosis of bone metastasis, PAP may be most frequently used as a screening procedure of bone metastasis. (Namekawa, K.)

  16. ALP conversion and the soft X-ray excess in the outskirts of the Coma cluster

    International Nuclear Information System (INIS)

    Kraljic, David; Rummel, Markus; Conlon, Joseph P.

    2015-01-01

    It was recently found that the soft X-ray excess in the center of the Coma cluster can be fitted by conversion of axion-like-particles (ALPs) of a cosmic axion background (CAB) to photons. We extend this analysis to the outskirts of Coma, including regions up to 5 Mpc from the center of the cluster. We extract the excess soft X-ray flux from ROSAT All-Sky Survey data and compare it to the expected flux from ALP to photon conversion of a CAB. The soft X-ray excess both in the center and the outskirts of Coma can be simultaneously fitted by ALP to photon conversion of a CAB. Given the uncertainties of the cluster magnetic field in the outskirts we constrain the parameter space of the CAB. In particular, an upper limit on the CAB mean energy and a range of allowed ALP-photon couplings are derived

  17. Continuous measurement of Radon emanations from soil and groundwaters in southern France (Alpes Maritimes). Preliminary results

    International Nuclear Information System (INIS)

    Oddou, A.; Nault, L.; Campredon, R.; Bernat, M.

    1983-01-01

    Two types of automated instruments which monitor the emission of radon from rocks and groundwaters are actually being set up in a few localities of the French-Italian Alpe-Maritimes (SE France). The first results are presented [fr

  18. Detecting an infrared photon within an hour. Transition-edge detector at ALPS-II

    Energy Technology Data Exchange (ETDEWEB)

    Dreyling-Eschweiler, Jan [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Hamburg Univ. (Germany). Inst. fuer Experimentalphysik; Horns, Dieter [Hamburg Univ. (Germany). Inst. fuer Experimentalphysik; Collaboration: ALPS-II collaboration

    2013-09-15

    An essential design requirement of the ALPS-II experiment is the efficient detection of single photons with a very low instrumental background of 10 {mu}Hz. In 2011 the ALPS collaboration started to set up a TES detector (Transition-Edge Sensor) for ALPS-II, the second phase of the experiment. Since mid of 2013 the setup is ready for characterization in the ALPS laboratory: an ADR cryostat (Adiabatic Demagnetization Refrigerator) as millikelvin environment, a low noise SQUID (Superconducting Quantum Interference Device) with electronics for read-out and a fiber-coupled high-efficient TES for near-infrared photons as sensor. First measurements have shown a good discrimination between noise and 1064 nm signals.

  19. Epigondolella abneptis and E. spatulata in the Lower Norian in the central Kamnik Alps, Slovenia

    Directory of Open Access Journals (Sweden)

    Anton Ramovš

    1994-12-01

    Full Text Available Epigondolella abneptis (Huckriede, 1958 and E. spatulata (Hayashi, 1968from the Lower Norian (Upper Triassic deeper marine micritic limestones with chert nodules and lenses in the locality Sleme, central Kamnik Alps, are presented.

  20. Detecting an infrared photon within an hour. Transition-edge detector at ALPS-II

    International Nuclear Information System (INIS)

    Dreyling-Eschweiler, Jan; Hamburg Univ.; Horns, Dieter

    2013-09-01

    An essential design requirement of the ALPS-II experiment is the efficient detection of single photons with a very low instrumental background of 10 μHz. In 2011 the ALPS collaboration started to set up a TES detector (Transition-Edge Sensor) for ALPS-II, the second phase of the experiment. Since mid of 2013 the setup is ready for characterization in the ALPS laboratory: an ADR cryostat (Adiabatic Demagnetization Refrigerator) as millikelvin environment, a low noise SQUID (Superconducting Quantum Interference Device) with electronics for read-out and a fiber-coupled high-efficient TES for near-infrared photons as sensor. First measurements have shown a good discrimination between noise and 1064 nm signals.

  1. Exploration of the South-Eastern Alps lithosphere with 3D refraction seismics project Alp 2002 – data acquisition in Slovenia

    Directory of Open Access Journals (Sweden)

    Andrej Gosar

    2003-06-01

    Full Text Available Using combined seismic refraction/wide-angle reflection method project Alp 2002 explored the contact zone between South-Eastern Alps, Dinarides and Pannonian basin. In a network of 12 profiles of 4100 km total length, which are spread over seven countries,1055 portable seismographs were deployed and 31 strong (300 kg explosions fired. In Slovenia 127 seismographs were deployed along five profiles totalling 575 km and two explosions fired near Vojnik and Gradin. The collected data will allow construction of athree-dimensional model of the lithosphere and will contribute to the understanding of the tectonics and geodynamics at the junction of European, Adriatic and Tisza plates.

  2. Statistically extrapolated nowcasting of summertime precipitation over the Eastern Alps

    Science.gov (United States)

    Chen, Min; Bica, Benedikt; Tüchler, Lukas; Kann, Alexander; Wang, Yong

    2017-07-01

    This paper presents a new multiple linear regression (MLR) approach to updating the hourly, extrapolated precipitation forecasts generated by the INCA (Integrated Nowcasting through Comprehensive Analysis) system for the Eastern Alps. The generalized form of the model approximates the updated precipitation forecast as a linear response to combinations of predictors selected through a backward elimination algorithm from a pool of predictors. The predictors comprise the raw output of the extrapolated precipitation forecast, the latest radar observations, the convective analysis, and the precipitation analysis. For every MLR model, bias and distribution correction procedures are designed to further correct the systematic regression errors. Applications of the MLR models to a verification dataset containing two months of qualified samples, and to one-month gridded data, are performed and evaluated. Generally, MLR yields slight, but definite, improvements in the intensity accuracy of forecasts during the late evening to morning period, and significantly improves the forecasts for large thresholds. The structure-amplitude-location scores, used to evaluate the performance of the MLR approach, based on its simulation of morphological features, indicate that MLR typically reduces the overestimation of amplitudes and generates similar horizontal structures in precipitation patterns and slightly degraded location forecasts, when compared with the extrapolated nowcasting.

  3. The glacial record of New Zealand's Southern Alps

    Science.gov (United States)

    Schaefer, J. M.; Denton, G.; Lowell, T.; Anderson, B.; Rinterknecht, V.; Schlosser, P.; Ivy-Ochs, S.; Kubik, P.; Schluechter, C.; Chinn, T.; Barrell, D.; Lifton, N.; Jull, T.

    2004-12-01

    We present detailed mapping and surface exposure dating using in-situ Be-10 and C-14 of the moraine set of Lake Pukaki, New Zealand's Southern Alps, spanning from the penultimate glaciation, over several Last Glacial Maximum (LGM) moraines, the late glacial event to Holocene glacial advances. New Zealand, a mountain ridge in the middle of the Southern Ocean, has one of the best preserved moraine records world-wide, offering the opportunity to reconstruct amplitude and timing of climate changes from Southern mid-latitudes, an area where paleoclimate data is scarce. The extensive mapping effort by G. Denton and colleagues (http://wyvern.gns.cri.nz/website/csigg/) provides a unique background for sample selection for Surface Exposure Dating. Our extensive data set (>40 samples analyzed so far) indicate that (i) the LGM in New Zealand terminated clearly prior to the Boelling/Alleroed warming, (ii) the late glacial advance is within uncertainties consistent with the timing of the Younger Dryas cold reversal; (iii) there occurred an early Holocene glacial event of the same amplitude than the Little Ice Age. This latter event is the first Holocene glacial event from the Southern Hemisphere dated by in-situ Be-10 and C-14.

  4. Advanced Large Area Plastic Scintillator Project (ALPS): Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L.; Geelhood, Bruce D.; Alzheimer, James M.; Crowell, Shannon L.; Sliger, William A.

    2008-02-05

    The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT "dark current" background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or "Back" detector, to both (1) minimize Compton background in the low-energy portion of the "Front" scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as impelmented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors.

  5. Environmental effects in the Alps. Proceedings. Alpine Umweltprobleme. Referate

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    Since 1970 the research and testing program of the Environmental Research Fund (Fond fuer Umweltstudien FUST-Tirol and Bonn) has been investigating into the various uses, environmental loads, the damage and different developments in the Alps (Achenkirch/Tirol). The project aims at assessing objective facts, causes, effects and concrete scientific data and make them available as a contribution to a conservation-minded treatment and utilization of ecosystems and as a basis of models promising a safe and reliable future environment without any further major environmental loads or damage. With the damage to forests obviously increasing, the managing committee decided to organize a meeting allowing an intermediate balance of the results and achievements gained so far. The session was also intended to be touching on new ways of finding further promising measures to effectfully check the environmental load. Decided on in autumn 1984, the FUST meeting on 'forest ecosystems' took place on June 13/14, 1985. The publication abstracted contains the eleven papers held on the meeting. Further interesting details were discussed in-between and in work-shops.

  6. Status of ELI-ALPS implementation (Conference Presentation)

    Science.gov (United States)

    Osvay, Karoly; Charalambidis, Dimitris; Antici, Patrizio; Dombi, Péter; Fulop, Lajos J.; Lepine, Franck; Mészáros, Gergo; Sansone, Giuseppe; Varju, Katalin G.

    2017-05-01

    The major research equipment of the Attosecond Light Pulse Source of the Extreme Light Infrastructure (ELI-ALPS) are driven by laser pulses of few cycle duration operating in the 100 W average power regime. The peak power and the repetition rate span from 1 TW at 100 kHz up to PW at 10 Hz. The systems are designed for stable and reliable operation, yet to deliver pulses with unique parameters, especially with unmatched fluxes and extreme bandwidths. This exceptional performance will enable the generation of secondary sources with exceptional characteristics, including light sources ranging from the THz to the X-ray spectral ranges, and particle sources. The experimental activities in the building complex to be inaugurated early 2017 will start with the installation of the two 100 kHz repetition rate, CEP stabilized lasers in May 2017. The MIR laser produces 0.15mJ, shorter than 4-optical-cylce pulses tunable between 2.5-3.9 µm. The first stage of the HR laser will provide pulses around 1 µm with 1 mJ energy and pulse duration less than 6.2 fs. The systems will be optically synchronized to each other with a temporal jitter below 1 fs. Along with the installation of the lasers, we will also start the assembly of the high harmonic beamlines and the THz laboratory, as well as nanoplasmonic experiments. The XUV bursts of light with attosecond duration are expected to be generated by the end of 2017.

  7. CLIM-RUN: Tourism cas study over the French Alps

    Science.gov (United States)

    Dubois, C.

    2012-04-01

    Climate information for societal use has becoming a major challenge for tourism management and adaptation in a context of strong climate variability and change. Within the CLIMRUN EU FP7, a case study on summer tourism in the French Alps has been identify. I will introduce the bottom-up approach use in the project where stakeholders and local users meet with climate experts. From those meetings, they thus identify the climate dependence and information which impact their summer activities over this region. All the activities are located in a mountainous region where outdoor leisure is the main economic driver of the region. It has emerged that the climate requirements are as well on past as on future climate information. On one side, the past climate parameters are found to be an invaluable information to evaluate the climate dependence of the different activities. A better knowledge as well as a growing interest in climate variability has been express to quantify the climate dependence on their activities. On the other side, the future climate information requested mainly on seasonal to decadal timescale. A particular interest has been express on the snow cover at the end of the winter season, evolution of heavy precipitations, heatwave, air temperatures and well as the water temperature of the mountainous lakes. Those climate variables are used to create comfort index under climate change. All those targeted climate information are based on on-going projects as well as future model development.

  8. ALPS - advanced limiter-divertor plasma-facing systems

    International Nuclear Information System (INIS)

    Allain, J. P.; Bastasz, R.; Brooks, J. N.; Evans, T.; Hassanein, A.; Luckhardt, S.; Maingi, R.; Mattas, R. F.; McCarthy, K.; Mioduszewski, P.; Mogahed, E.; Moir, R.; Molokov, S.; Morely, N.; Nygren, R.; Reed, C.; Rognlien, T.; Ruzic, D.; Sviatoslavsky, I.; Sze, D.; Tillack, M.; Ulrickson, M.; Wade, P. M.; Wong, C.; Wooley, R.

    1999-01-01

    The Advanced Limiter-divertor Plasma-facing Systems (ALPS) program was initiated in order to evaluate the potential for improved performance and lifetime for plasma-facing systems. The main goal of the program is to demonstrate the advantages of advanced limiter/divertor systems over conventional systems in terms of power density capability, component lifetime, and power conversion efficiency, while providing for safe operation and minimizing impurity concerns for the plasma. Most of the work to date has been applied to free surface liquids. A multi-disciplinary team from several institutions has been organized to address the key issues associated with these systems. The main performance goals for advanced limiters and diverters are a peak heat flux of >50 MW/m 2 ,elimination of a lifetime limit for erosion, and the ability to extract useful heat at high power conversion efficiency (approximately40%). The evaluation of various options is being conducted through a combination of laboratory experiments, modeling of key processes, and conceptual design studies. The current emphasis for the work is on the effects of free surface liquids on plasma edge performance

  9. Fog Chemistry at Different Altitudes in the Swiss Alps

    Science.gov (United States)

    Michna, P.; Eugster, W.; Wanner, H.

    2010-07-01

    During two extended summer seasons in 2006 and 2007, we installed two battery driven versions of the Caltech active strand cloud water collector (MiniCASCC) at the Niesen mountain in the northern Swiss Alps. Along, we measured air temperature, relative humidity, wind, and visibility. During these two field operation phases we gained weekly samples of fogwater, where we analysed the major anions and cations, and the stable water isotopes δD and δ18O. The fog collectors were installed at an altitude of 2300 and 1600 m asl to resolve altitudinal differences in fog chemistry. We found a large variability between the events, but no clear altitudinal gradient. At both sites, the most important ions were nitrate, ammonium, and sulphate. Higher concentrations occured preferably in late spring (start of sampling period) and in autumn (end of sampling). Compared to previous studies at lower elevations in the Swiss Plateau during wintertime, our measurements showed considerable lower ion loads in the fogwater. The combination of these results suggest that lowest ion loads are found in convective clouds with a short lifetime and that the highest ion loads occur during radiation fog events at lower elevations.

  10. Advanced Large Area Plastic Scintillator Project (ALPS): Final Report

    International Nuclear Information System (INIS)

    Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L.; Geelhood, Bruce D.; Alzheimer, James M.; Crowell, Shannon L.; Sliger, William A.

    2008-01-01

    The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT 'dark current' background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or 'Back' detector, to both (1) minimize Compton background in the low-energy portion of the 'Front' scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as implemented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors

  11. Serotonin syndrome

    Science.gov (United States)

    Hyperserotonemia; Serotonergic syndrome; Serotonin toxicity; SSRI - serotonin syndrome; MAO - serotonin syndrome ... brain area. For example, you can develop this syndrome if you take migraine medicines called triptans together ...

  12. Partial Least Squares Based Gene Expression Analysis in EBV- Positive and EBV-Negative Posttransplant Lymphoproliferative Disorders.

    Science.gov (United States)

    Wu, Sa; Zhang, Xin; Li, Zhi-Ming; Shi, Yan-Xia; Huang, Jia-Jia; Xia, Yi; Yang, Hang; Jiang, Wen-Qi

    2013-01-01

    Post-transplant lymphoproliferative disorder (PTLD) is a common complication of therapeutic immunosuppression after organ transplantation. Gene expression profile facilitates the identification of biological difference between Epstein-Barr virus (EBV) positive and negative PTLDs. Previous studies mainly implemented variance/regression analysis without considering unaccounted array specific factors. The aim of this study is to investigate the gene expression difference between EBV positive and negative PTLDs through partial least squares (PLS) based analysis. With a microarray data set from the Gene Expression Omnibus database, we performed PLS based analysis. We acquired 1188 differentially expressed genes. Pathway and Gene Ontology enrichment analysis identified significantly over-representation of dysregulated genes in immune response and cancer related biological processes. Network analysis identified three hub genes with degrees higher than 15, including CREBBP, ATXN1, and PML. Proteins encoded by CREBBP and PML have been reported to be interact with EBV before. Our findings shed light on expression distinction of EBV positive and negative PTLDs with the hope to offer theoretical support for future therapeutic study.

  13. Epstein-Barr virus associated T-cell lymphoproliferative disease misdiagnosed as ulcerative colitis: a case report.

    Science.gov (United States)

    Zheng, Xiaodan; Xie, Jianlan; Zhou, Xiaoge

    2015-01-01

    Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disease (LPD) is not uncommon in China, but gastrointestinal involvement is very rare. We report on an immunocompetent patient with EBV-associated T-cell LPD of the colon. The 26-year-old man was initially misdiagnosed with ulcerative colitis (UC). A colon biopsy revealed the presence of small to medium-sized lymphoid cells infiltrating the intestinal wall. The neoplastic cells expressed CD3, CD5, and granzyme B, not CD56. EBV-encoded small ribonucleic acid was detected in the tumor cells of the colon as well as the lymph node, and the T-cell receptor gene rearrangement result displayed δ gene monoclonal rearrangement. The patient died 2 moths after the diagnosis. The clinical course of EBV-associated T-cell LPD is aggressive and the prognosis is poor, the wrong diagnosis may delay treatment. Therefore, we should be very careful to prevent misdiagnosis. When patients have multiple intestinal ulcers that are not typical of UC and the clinical course is unusual, although morphology looks like inflammatory change, pathologist should consider the possibility of EBV-associated LPD. The treatment strategy and prognosis of these two diseases are different.

  14. Epstein-Barr virus load monitoring: its role in the prevention and management of post-transplant lymphoproliferative disease.

    Science.gov (United States)

    Rowe, D T; Webber, S; Schauer, E M; Reyes, J; Green, M

    2001-06-01

    The Epstein-Barr virus load in the peripheral blood at the time of diagnosis of post-transplant lymphoproliferative disease (PTLD) is elevated 1000- to 10,000-fold compared to the level detected in normal latency. With the use of quantitative polymerase chain reaction (PCR), changes in the viral load over time can be measured with a two- to fourfold accuracy. This has allowed early detection of first-time infections and reactivations that may lead to PTLD and has provided an opportunity to intervene before symptomatic disease has occurred. Viral load monitoring has also been used to follow patients with PTLD and, along with other parameters, provided an assessment of the effectiveness of therapeutic protocols. Viral load monitoring has led to the discovery that at least two-thirds of transplant recipients become persistent viral load carriers. While the persistent load appears to be largely carried in latently infected memory B cells, more work is needed to clearly define this type of persistent infection and determine the risks associated with it. New diagnostic tests need to be developed to distinguish the persistent latent viral loads from viral loads that are likely to become symptomatic PTLD.

  15. Fallout Radionuclides as Tracers in Southern Alps Sediment Studies

    Science.gov (United States)

    Carey, A. E.; Karanovic, Z.; Dibb, J. E.

    2005-12-01

    The primary geologic processes shaping the landscape are physical and chemical weathering and the transport of solids by erosion. As part of our studies on the coupling between physical erosion and chemical weathering, we have determined depositional and erosional processes in New Zealand's tectonically active, rapidly uplifting Southern Alps, specifically focusing on the Hokitika River watershed. The South Island watersheds we are studying are subject to extreme orographic precipitation (as high as 7-12 m annually) and high landslide frequency, but have modest topography due to the rapid erosion. In concert with our studies of chemical weathering and physical erosion, we have used the atmospherically-delivered radionuclides of 7Be, 137Cs and 210Pbexcess to determine the relative magnitude of particle residence time in the high elevation Cropp and Whitcombe subwatersheds and the rates of sedimentation. One- and two-box modeling with 7Be and 210Pbexcess was used to determine soil and sediment residence times. Residence time of fine suspended particles is short and particles can travel the length of the river during a single storm, probably due to the short duration, high-intensity rainfalls which produce rapidly moving, steep flood waves. The readily detected peak of 137Cs activity in Cropp terrace and Hokitika gorge soils yielded sedimentation rates of 0.06-0.12 cm yr-1. At the Cropp terrace, inventory models of 210Pbexcess yield soil accumulation rates significantly less than those determined using the 137Cs activity peak. We attribute the differences to overestimation of 210Pbexcess in surface soils and to contrasting fallout fluxes, geochemical behavior and radionuclide contents of sedimenting materials. Total inventories of 210Pbexcess in soils greatly exceed the expected direct atmospheric deposition, suggesting that lateral transport of this nuclide occurs within the watershed. At the Hokitika gorge, all nuclides studied yielded similar sedimentation rates

  16. Eclogitic metatrondhjemites from metaophiolites of the Western Alps

    Science.gov (United States)

    Martin, Silvana; Tartarotti, Paola; Meyzen, Chrstine; Benciolini, Luca; Toffolo, Luca

    2016-04-01

    Eclogitic metatrondhjemites from metaophiolites of the Western Alps Martin S.**, Tartarotti P.*, Meyzen C. **, Benciolini L.***, Toffolo L. ** *Dipartimento di Scienze della Terra, Università degli Studi di Milano ** Dipartimento di Geoscienze, Università di Padova *** Dipartimento di Chimica, Fisica e Ambiente, Università di Udine In the Urtier valley (southern Aosta Valley, Italy), the Piemonte metaophiolites mainly consist of serpentinized peridotites including pods and boudinaged layers of Fe-metagabbro and trondhjemite transposed in the main eclogitic foliation. The contact between serpentinized peridotites and Fe-metagabbro/trondhjemite is locally lined by chloriteschist and rodingite. The high pressure parageneses in the Fe-metagabbro are omphacite-garnet-rutile-glaucophane-phengite, and in the metatrondhjemite plagioclase-quartz-phengite-clinozoisite-epidote-garnet, respectively. Bulk-rock major and trace elements in addition to O isotope analyses were performed in both rock types. Fe-metagabbros are characterized by MgO wt% ranging between 6.11 and 9.63%, ∑REE= 20-101 ppm, (La/Yb)N = 0.22-0.91; trondhjemites have SiO2 43%, Al2O3 ranging between 21 and 24%, CaO ranging between 17 and 20%, ∑REE = 172 - 272 ppm, (La/Yb)N ranging between 7.78 and 13.70. The δ18O is 5.9 ‰ in a Fe-metagabbro sample and 7.4 ‰ in a trondhjemite sample, suggesting that these rocks have been affected by a weak oceanic low temperature alteration. The high CaO content may indicate a metasomatic process which could have occurred during the oceanic stage or at high pressure conditions.

  17. La Directísima en los Alpes, Austria

    Directory of Open Access Journals (Sweden)

    Schmidt, Wilhelm

    1979-06-01

    Full Text Available This article deals with the construction procesa of the «straight» expressway through the Tauern AIps, where several engineering works deserve special mention: — The Tauern Tunnel, 6.4 km In length. — The Katschberg Tunnel, 5.4 km In length. — The Eben-Pongan cloverleaf. — The Liesertal stretch, 75 per 100 of its length being tunnels and viaducts. The most important of this Is the Tauern Tunnel where, owing to the serious problems encountered in the brittle character of the soil, the Austrian tunnel excavation process was used, this method consisting in tensing the mountain soil in order to be able to counteract the high pressures occurring. This tunnel has a 600 m long, 11 m diameter ventilation shaft, the largest of its kind in the World.

    Se trata, en este artículo, del proceso de construcción de la Autopista de Tauern, La Directísima, en los Alpes, en la que destacan varias obras: — Túnel de Tauern, de 6,4 km de longitud. — Túnel de Katschberg, de 5,4 km de longitud. — Punto de enlace Eben-Pongau. — Tramo de Liesertal, realizado en un 75 por 100 mediante viaductos y túneles. La obra más importante es el túnel de Tauern donde, debido a los grandes problemas surgidos por la naturaleza quebradiza del terreno, hubo de emplearse un método austríaco de perforación de túneles consistente en poner en tensión la montaña para, de esta manera, contrarrestar las altas presiones que se producen. Este túnel tiene un pozo de ventilación de 600 m de longitud y 11 m de diámetro de perforación. Es el pozo vertical más grande del mundo.

  18. Beals Syndrome

    Science.gov (United States)

    ... the syndrome. How does Beals syndrome compare with Marfan syndrome? People with Beals syndrome have many of the ... bone) and aortic enlargement problems as people with Marfan syndrome, and treatments for these problems are the same. ...

  19. Nuclear translocation of the cytoskeleton-associated protein, smALP, upon induction of skeletal muscle differentiation

    International Nuclear Information System (INIS)

    Cambier, Linda; Pomies, Pascal

    2011-01-01

    Highlights: → The cytoskeleton-associated protein, smALP, is expressed in differentiated skeletal muscle. → smALP is translocated from the cytoplasm to the nucleus of C2C12 myoblasts upon induction of myogenesis. → The differentiation-dependent nuclear translocation of smALP occurs in parallel with the nuclear accumulation of myogenin. → The LIM domain of smALP is essential for the nuclear accumulation of the protein. → smALP might act in the nucleus to control some critical aspect of the muscle differentiation process. -- Abstract: The skALP isoform has been shown to play a critical role in actin organization and anchorage within the Z-discs of skeletal muscles, but no data is available on the function of the smALP isoform in skeletal muscle cells. Here, we show that upon induction of differentiation a nuclear translocation of smALP from the cytoplasm to the nucleus of C2C12 myoblasts, concomitant to an up-regulation of the protein expression, occurs in parallel with the nuclear accumulation of myogenin. Moreover, we demonstrate that the LIM domain of smALP is essential for the nuclear translocation of the protein.

  20. Low temperature thermochronology in the Easter Alps. New data, interpretations and perspectives.

    Science.gov (United States)

    Wölfler, Andreas

    2015-04-01

    The aim of this study is to evaluate new and published low temperature thermochronological data of the Eastern Alps in terms of its Mesozoic and Cenozoic tectonic evolution and the possible connection with deep seated lithospheric processes. In the Eastern Alps, the tectonic units that originate from the Penninic domain are buried beneath the Austroalpine nappe stack. Overthrusting of the Austroalpine nappes over the Penninic units occurred throughout the Cretaceous and lasted until the Eocene. During lateral tectonic extrusion in Oligocene to Miocene times the footwall penninic units exposed in the Tauern Window, were tectonically exhumed from below the Austroalpine hanging wall. This is well documented by Miocene to Pliocene zircon- and apatite fission track (ZFT, AFT) and (U-Th)/He data. However, the Austroalpine hanging wall shows a more complex age pattern. Late Cretaceous ZFT data reflect post-metamorphic exhumational cooling after Eo-Alpine metamorphism that goes along with an extensional phase that affected large parts of the Eastern Alps. Paleogene AFT and apatite (U-Th)/He data of the Austroalpine units to the east of the Tauern Window reflect exhumation of this area that supplied clastic material, the so-called Augenstein formation. Exhumation and erosion of the area left a probably hilly surface in Early Miocene times that was only moderately uplifted since then. These areas are well known for paleosurfaces exposed in the Gurktal- Kor- and Seckauer Alps to the east of the Tauern Window and in the central and eastern Northern Calcareous Alps. However, distinct parts of the Austroalpine hanging wall experienced substantial exhumation and surface uplift in the Miocene, contemporaneous to the exhumation of Penninic units and lateral extrusion of the Eastern Alps. These areas are restricted to the south and northeast of the Tauern Window and are characterized by steep and rugged reliefs that contrast the hilly and moderately shaped reliefs of the

  1. Quantifying the Eocene to Pleistocene topographic evolution of the southwestern Alps, France and Italy

    Science.gov (United States)

    Fauquette, Séverine; Bernet, Matthias; Suc, Jean-Pierre; Grosjean, Anne-Sabine; Guillot, Stéphane; van der Beek, Peter; Jourdan, Sébastien; Popescu, Speranta-Maria; Jiménez-Moreno, Gonzalo; Bertini, Adele; Pittet, Bernard; Tricart, Pierre; Dumont, Thierry; Schwartz, Stéphane; Zheng, Zhuo; Roche, Emile; Pavia, Giulio; Gardien, Véronique

    2015-02-01

    We evaluate the topographic evolution of the southwestern Alps using Eocene to Pleistocene pollen data combined with existing sedimentological, petrographic and detrital geo- and thermochronological data. We report 32 new pollen analyses from 10 sites completed by an existing dataset of 83 samples from 14 localities situated across the southwestern Alps, including both the pro- and the retro-foreland basins. The presence of microthermic tree pollen (mainly Abies, Picea) indicates that this part of the mountain belt attained elevations over 1900 m as early as the Oligocene. Inferred rapid surface uplift during the mid-Oligocene coincided with a previously documented brief phase of rapid erosional exhumation, when maximum erosion rates may have reached values of up to 1.5-2 km/Myr. Slower long-term average exhumation rates of ∼0.3 km/Myr since the Late Oligocene helped maintaining the high Alpine topography of the southwestern Alps until today. The relative abundances of meso-microthermic tree pollen (Cathaya, Cedrus and Tsuga) and microthermic tree pollen (Abies, Picea) in the pro- and retro-foreland basin deposits, indicate that the present-day asymmetric topography, with a relatively gentle western flank and steeper eastern flank, was established early in the southwestern Alps, at least since the Early Miocene, and possibly since the Oligocene or Late Eocene. Therefore, the high topography and asymmetric morphology of this part of the Alps has been maintained throughout the past ∼30 Ma.

  2. Hydrological and meteorological aspects of floods in the Alps: an overview

    Directory of Open Access Journals (Sweden)

    Baldassare Bacchi

    2003-01-01

    Full Text Available This introductory paper presents and summarises recent research on meteorological and hydrological aspects of floods in the Alps. The research activities were part of the international research project RAPHAEL (Runoff and Atmospheric Processes for flood HAzard forEcasting and controL together with experiments within the Special Observing Period-SOP conducted in autumn 1999 for the Mesoscale Alpine Programme —MAP. The investigations were based on both field experiments and numerical simulations, using meteorological and hydrological models, of ten major floods that occurred in the past decade in the European Alps. The two basins investigated were the Ticino (6599 km2 at the Lago Maggiore outlet on the southern side of the Alps and the Ammer catchment (709 km2 in the Bavarian Alps. These catchments and their sub-catchments cover an appropriate range of spatial scales with which to investigate and test in an operational context the potential of both mesoscale meteorological and distributed hydrological models for flood forecasting. From the data analyses and model simulations described in this Special Issue, the major sources of uncertainties for flood forecasts in mid-size mountain basins are outlined and the accuracy flood forecasts is assessed. Keywords: floods, mountain hydrology, meteorological models, Alps

  3. Natural gas seeps in the French Alps: Sources and pathways

    Science.gov (United States)

    Kloppmann, Wolfram; Blessing, Michaela; Proust, Eric; Gal, Frédéric; Bentivegna, Gaetan; Henry, Benoit; Defossez, Pierrick; Catherine, Lerouge; Humez, Pauline; Mayer, Bernhard; Millot, Romain; Gaucher, Eric

    2016-04-01

    Natural gas emanations are part of the geochemical baseline to take into account when assessing global greenhouse gas emissions and potential impacts of conventional and unconventional gas exploration and exploitation on groundwater. Examples of such natural gas macro-seeps are known in several parts of the world (Etiope et al., 2009). Only a limited number of them have been characterized for their gas and isotopic compositions. Such analyses can provide essential information for baseline studies, providing insight in the sources (biogenic vs. thermogenic or modified thermogenic) and pathways of such seeps and may allow for distinction of natural seeps from stray gas leakage associated with human activities. Here, we report gas concentrations and multi-isotope data (δ13C and δ2H of methane and ethane, δ13C and δ18O of CO2, 3He/4He ratio) of two gas seeps in the French subalpine chains, both in a similar geological and structural position within Middle Jurassic claystones along the eastern border of the large synclinal structures of the Vercors and the Chartreuse massifs (Moss, 1992). The "ardent fountain" (fontaine ardente) of Le Gua, 30 km south of Grenoble has most likely the longest continuous written record of existence of any individual natural gas seep, mentioned explicitly as early as the first quarter of the 5th century (Augustin of Hippo (St. Augustin), approx. 426) This natural seep was described in the past as a "wet seep" associated with a spring, whereas the second investigated seep, Rochasson near Meylan north of Grenoble, is a dry seep. Both seeps contain methane and ethane with thermogenic C and H isotope signatures, comparable with a seep in the Northern Swiss Alps at Giswil (Etiope et al., 2010) but with a higher dryness (C1/(C2+C3)>1000) for the Le Gua seep, possibly due to molecular fractionation upon advective fluid+gas migration (Etiope et al., 2009). Maturity (R0) of the reservoir rocks deduced from δ13C(CH4), δ13C(C2H6) is similar to

  4. Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps

    Science.gov (United States)

    Haeberli, W.; Chiarle, M.; Mortara, G.; Mazza, A.

    The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing on a thick sediment bed. Problems with floods, avalanches and debris flows from this ice body have been known for extended time periods. Most recently, however, the evolution of this highly dynamic environ- ment has become more dramatic. An outburst of Lago delle Locce, an ice-dammed lake at the confluenec of the tributary Ghiacciaio delle Locce with Ghiacciaio del Belvedere, caused heavy damage in 1979 and necessitated site investigation and con- struction work to be done for flood protection. The intermittent glacier growth ten- dency in the 1970es induced strong bulging of the glacier surface and, in places, caused the glacier tongue to override historical morains and to destroy newly-grown forest stands. A surge-type flow acceleration started in the lower parts of the Monte- Rosa east face during summer 2000, leading to strong crevassing and deformation of Ghiacciaio del Belvedere and extreme bulging of its orographic right margin. High water pressure and accelerated movement lasted into winter 2001/2002: the ice now started overriding the LIA moraine near Rifugio Zamboni of the CAI. In addition but rather independently, a most active detachment zone for rock falls and debris flows developed for several years now in the east face of Monte Rosa, somewhat more to the south of the accelerated glacier movement and at an altitude where relatively warm permafrost must be expected. Besides the scientific interest in these phenomena, the growing hazard potential to the local infrastructure must be considered seriously. Es- pecially potentials for the destabilization of large rock and ice masses in the

  5. Epstein-Barr Virus-positive T-cell Lymphoproliferative Disease Following Umbilical Cord Blood Transplantation for Acute Myeloid Leukemia.

    Science.gov (United States)

    Yui, Shunsuke; Yamaguchi, Hiroki; Imadome, Ken-ichi; Arai, Ayako; Takahashi, Mikiko; Ohashi, Ryuji; Tamai, Hayato; Moriya, Keiichi; Nakayama, Kazutaka; Shimizu, Akira; Inokuchi, Koiti

    2016-01-01

    We report a case of the extremely rare condition Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (LPD) which occurred after umbilical cord blood transplantation. A 25-year-old Japanese man underwent cord blood transplantation from a male human leukocyte antigen 4/6-matched donor due to acute myeloid leukemia with trisomy 8. Bone marrow examination on day 30 showed chimerism with at least 90% donor cells and complete hematological response. Chronic symptoms of graft-versus-host disease appeared only on the skin and were successfully treated with cyclosporine alone. Three years later, however, the patient experienced repeated cold-like symptoms and was hospitalized with liver dysfunction. A high fever developed and was followed by significant edema of the right side of the face. The EBV DNA copy number in whole peripheral blood was 2×10(4)/mL. Liver biopsy showed invasion of EBV-infected CD8-positive T cells. Southern blotting analysis of the whole peripheral blood showed that the T-cell receptor Cβ1 rearrangement was positive. On the basis of these results, EBV-positive T-cell LPD was diagnosed and treated with prednisolone, cyclosporine, and etoposide, followed by cyclophosphamide, doxorubicin, vincristine, and prednisone. However, the patient died of cardiac function failure, pneumonia, and pulmonary hemorrhage, all of unidentified cause. Most cases of EBV-related LPD after hematopoietic stem cell transplantation consist of EBV-positive B-cell LPD, and, to our knowledge, de novo EBV-positive T-cell LPD subsequent to transplantation has not been previously reported.

  6. POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS: ROLE OF VIRAL INFECTION, GENETIC LESIONS AND ANTIGEN STIMULATION IN THE PATHOGENESIS OF THE DISEASE

    Directory of Open Access Journals (Sweden)

    Daniela Capello

    2009-11-01

    Full Text Available Post-transplant lymphoproliferative disorders (PTLD are a life-threatening complication of solid organ transplantation or, more rarely, hematopoietic stem cell transplantation. The majority of PTLD is of B-cell origin and associated with Epstein–Barr virus (EBV infection. PTLD generally display involvement of extranodal sites, aggressive histology and aggressive clinical behavior. The molecular pathogenesis of PTLD involves infection by oncogenic viruses, namely Epstein-Barr virus, as well as genetic or epigenetic alterations of several cellular genes. At variance with lymphoma arising in immunocompetent hosts, whose genome is relatively stable, a fraction of PTLD are characterized by microsatellite instability as a consequence of defects in the DNA mismatch repair mechanism. Apart from microsatellite instability, molecular alterations of cellular genes recognized in PTLD include alterations of cMYC, BCL6, TP53, DNA hypermethylation, and aberrant somatic hypermutation of protooncogenes. The occurrence of IGV mutations in the overwhelming majority of PTLD documents that malignant transformation targets germinal centre (GC B-cells and their descendants both in EBV–positive and EBV–negative cases. Analysis of phenotypic markers of B-cell histogenesis, namely BCL6, MUM1 and CD138, allows further distinction of PTLD histogenetic categories. PTLD expressing the BCL6+/MUM1+/-/CD138- profile reflect B-cells actively experiencing the GC reaction, and comprise diffuse large B-cell lymphoma (DLBCL centroblastic and Burkitt lymphoma. PTLD expressing the BCL6-/MUM1+/CD138- phenotype putatively derive from B-cells that have concluded the GC reaction, and comprise the majority of polymorphic PTLD and a fraction of DLBCL immunoblastic. A third group of PTLD is reminiscent of post-GC and preterminally differentiated B-cells that show the BCL6-/MUM1+/CD138+ phenotype, and are morphologically represented by either polymorphic PTLD or DLBCL immunoblastic.

  7. Preliminary experience on the use of PET/CT in the management of pediatric post-transplant lymphoproliferative disorder.

    Science.gov (United States)

    Guerra-García, Pilar; Hirsch, Steffen; Levine, Daniel S; Taj, Mary M

    2017-12-01

    Post-transplant lymphoproliferative disorder (PTLD) is a well-known complication following prolonged immunosuppression. Contrary to other lymphomas, there is no standardized imaging approach to assess PTLD either at staging or for response to therapy. Positron emission tomography/computed tomography (PET/CT) is an imaging modality that has proven to be useful in lymphoma. However, there is still limited data concerning its use in pediatric PTLD. Our study evaluates the use of PET/CT in pediatric PTLD at our institution. To assess the role of PET/CT in pediatric PTLD, we reviewed the pediatric patients with PTLD who had undergone PET/CT at our institution between 2000 and 2016. Nine patients were identified. Six had PET/CT at diagnosis. All lesions seen on CT were identified with PET/CT. Fourteen PET/CTs were done during treatment. Eight PET/CTs were negative, including three where CT showed areas of uncertain significance. In these cases, PET/CT helped us to stop treatment and the patients remain in remission after a long follow-up (mean 74.3 months; range 12.4-180.9 months). PET/CT revealed additional disease in two cases, therefore treatment was intensified. Six biopsies and close follow-up was done to confirm PET/CT results. In one case, PET/CT did not identify central nervous system involvement demonstrated on magnetic resonance imaging. PET/CT may have an important role in the staging and follow-up of pediatric PTLD. In our cohort, PET/CT was helpful in staging and assessing treatment response and in clarifying equivocal findings on other imaging modalities. © 2017 Wiley Periodicals, Inc.

  8. P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases

    International Nuclear Information System (INIS)

    Yoshimori, Mayumi; Takada, Honami; Imadome, Ken-Ichi; Kurata, Morito; Yamamoto, Kouhei; Koyama, Takatoshi; Shimizu, Norio; Fujiwara, Shigeyoshi; Miura, Osamu; Arai, Ayako

    2015-01-01

    Epstein–Barr virus-positive T-cell lymphoproliferative diseases (EBV-T-LPDs) are rare lymphomas with poor prognosis. Although chemotherapeutic strategies such as CHOP have been often selected, they have exhibited only limited efficacy. To clarify the mechanism of chemoresistance, we examined P-glycoprotein (P-gp) expression. P-gp acts as an energy-dependent efflux pump that excretes drugs from the cytoplasm, resulting in low-intracellular drug concentrations and poor sensitivity to chemotherapy. We examined P-gp expression in EBV-positive cells by immunohistochemistry staining in three patients of EBV-T-LPDs and the expression was detected in all patients. We also examined mdr1 mRNA expression by reverse-transcriptase polymerase-chain reaction (RT-PCR) in EBV-positive tumor cells from these patients and additional three patients. The expression was detected in all examined patients. In five EBV-T-LPDs patients, P-gp function was detected by Rhodamine-123 efflux assay in these cells. The efflux was inhibited by treatment with a P-gp inhibitor, cyclosporine A (CsA). We also examined and detected P-gp expression in EBV-positive T-cell lines SNT8 and SNT16 established from EBV-T-LPDs patients, by RT-PCR and western blotting. The function was also detected by Rhodamine-123 efflux in these cell lines. Inhibition and knock down of P-gp by CsA and siRNA, respectively, enhanced etoposide- and doxorubicin-induced cell death in the EBV-positive T-cell lines. Finally, we infected the T-cell line MOLT4 with EBV, and found that mdr1 mRNA expression and Rhodamine 123 efflux were upregulated after infection. These results indicated that enhanced P-gp expression contributed to the chemoresistance of EBV-T-LPDs

  9. Structural diversity of a family of aluminophosphates with Al/P ratio of non-unity

    Science.gov (United States)

    Yu, Jihong; Xu, Ruren; Li, Jiyang

    2000-05-01

    A family of organically templated aluminophosphates (denoted AlPOs) with an Al/P ratio of non-unity has been prepared with 1-D chain, 2-D layer and 3-D open-framework architectures. Their inorganic parts are constructed from alternating Al-centered polyhedra (AlO 4, AlO 5, AlO 4(OH 2) 2) and P-centered tetrahedra P(OAl) nO 4- n ( n=0, 1, 2, 3). The existence of terminal POH and/or PO groups in the structures results in the deviation of Al/P ratio from unity, and the commonly encountered Al/P ratios are 1/2, 3/5, 2/3, 3/4, 4/5 and 5/6. This review will discuss the structural features of these AlPOs with various dimensionalities and stoichiometries.

  10. PCDD/F and PCB in spruce forests of the Alps

    Energy Technology Data Exchange (ETDEWEB)

    Offenthaler, I., E-mail: ivo.offenthaler@umweltbundesamt.a [Austrian Environment Agency, Spittelauer Laende 5, 1090 Vienna (Austria); Bassan, R. [Regional Agency for Environmental Prevention and Protection of Veneto (Italy); Belis, C. [Regional Agency for Environmental Protection of Lombardia (Italy); Jakobi, G.; Kirchner, M. [Helmholtz Zentrum Muenchen (German Research Centre for Environmental Health) (Germany); Kraeuchi, N. [WSL-Swiss Federal Institute for Forest, Snow and Landscape Research (Switzerland); Moche, W. [Austrian Environment Agency, Spittelauer Laende 5, 1090 Vienna (Austria); Schramm, K.-W. [Helmholtz Zentrum Muenchen (German Research Centre for Environmental Health) (Germany); Sedivy, I. [WSL-Swiss Federal Institute for Forest, Snow and Landscape Research (Switzerland); Simoncic, P. [Slovenian Forestry Institute (Slovenia); Uhl, M.; Weiss, P. [Austrian Environment Agency, Spittelauer Laende 5, 1090 Vienna (Austria)

    2009-12-15

    PCDD/F and PCB concentrations in remote mountainous spruce stands of the Central European Alps show strong geographic variation. Independent of the matrix (0.5 year old needles, humus or mineral soil), the highest pollutant levels were always found at the lateral zones of the mountain range. High levels coincided with strong precipitation, particularly along the northern margin of the study region. The most volatile PCB congener propagated farther into the colder, drier central Alps than the heavier species. Matrices with different accumulation history (needles and humus) repeatedly reflected different spatial immission patterns. Consistent with its much longer exposure, pollutant levels in humus exceeded those of needles by up to two orders of magnitude. Needle contamination varied with altitude but the vertical trends were highly variable between transsects and changed between years, too. - Dioxin-like pollution of forests in the Alps shows strong geographic variation.

  11. Study geomorphology, past and present, linear trench, tectonics relationship between Pyrenees and Alps

    Science.gov (United States)

    Guillemot, J. (Principal Investigator)

    1974-01-01

    The author has identified the following significant results. ERTS-1 images obviously show up some large linear features trending N 80 E or N 30 E common to both Alps and Pyrenees. One of them, the Ligurian Fault, had been previously forecast by Laubscher in an interpretation of the Alps by the plate tectonic theory, but it extends westward farthest from the Alps, cutting the Pyrenees axis. These lineaments have been interpreted as reflections of deep seated wrench faults in the surficial part of the sedimentary series. A large set of such lineaments is perceptible in western Europe, such as the Guadalquivir Fault in southern Spain, Ligurian Fault, Insubrian Fault, Northern-Jura Fault, Metz Fault. Perhaps these may be interpreted as transform faults of the mid-Atlantic ridge or of a paleo-rift seated in the Rhine-Rhone graben.

  12. Immunoglobulin heavy-chain fluorescence in situ hybridization-chromogenic in situ hybridization DNA probe split signal in the clonality assessment of lymphoproliferative processes on cytological samples.

    Science.gov (United States)

    Zeppa, Pio; Sosa Fernandez, Laura Virginia; Cozzolino, Immacolata; Ronga, Valentina; Genesio, Rita; Salatiello, Maria; Picardi, Marco; Malapelle, Umberto; Troncone, Giancarlo; Vigliar, Elena

    2012-12-25

    The human immunoglobulin heavy-chain (IGH) locus at chromosome 14q32 is frequently involved in different translocations of non-Hodgkin lymphoma (NHL), and the detection of any breakage involving the IGH locus should identify a B-cell NHL. The split-signal IGH fluorescence in situ hybridization-chromogenic in situ hybridization (FISH-CISH) DNA probe is a mixture of 2 fluorochrome-labeled DNAs: a green one that binds the telomeric segment and a red one that binds the centromeric segment, both on the IGH breakpoint. In the current study, the authors tested the capability of the IGH FISH-CISH DNA probe to detect IGH translocations and diagnose B-cell lymphoproliferative processes on cytological samples. Fifty cytological specimens from cases of lymphoproliferative processes were tested using the split-signal IGH FISH-CISH DNA probe and the results were compared with light-chain assessment by flow cytometry (FC), IGH status was tested by polymerase chain reaction (PCR), and clinicohistological data. The signal score produced comparable results on FISH and CISH analysis and detected 29 positive, 15 negative, and 6 inadequate cases; there were 29 true-positive cases (66%), 9 true-negative cases (20%), 6 false-negative cases (14%), and no false-positive cases (0%). Comparing the sensitivity of the IGH FISH-CISH DNA split probe with FC and PCR, the highest sensitivity was obtained by FC, followed by FISH-CISH and PCR. The split-signal IGH FISH-CISH DNA probe is effective in detecting any translocation involving the IGH locus. This probe can be used on different samples from different B-cell lymphoproliferative processes, although it is not useful for classifying specific entities. Cancer (Cancer Cytopathol) 2012;. © 2012 American Cancer Society. Copyright © 2012 American Cancer Society.

  13. Preventing acute rejection, Epstein-Barr virus infection, and posttransplant lymphoproliferative disorders after kidney transplantation: Use of aciclovir and mycophenolate mofetil in a steroid-free immunosuppressive protocol

    DEFF Research Database (Denmark)

    Birkeland, S.A.; Andersen, H.K.; Hamilton-Dutoit, Stephen Jacques

    1999-01-01

    Background: A widely held view is that any increase in the potency of an immunosuppressive agent will lead to an increase in infection and malignancy, such as life-threatening Epstein-Barr virus (EBV) induced posttransplant lymphoproliferative disorders (PTLD), We tested this paradigm by studying......; the effect of adding mofetil to a steroid-free protocol under cover of high-dose aciclovir prophylaxis on the number of acute rejections, EBV infections and PTLDs after kidney transplantation. Methods: EBV serology was performed in 267 consecutive renal transplantations (1990-1997), All were treated...

  14. PARÁMETROS BIOQUÍMICOS ENZIMÁTICOS (ALT, AST, ALP, Γ-GT, LDH EN NIÑOS CON LEUCEMIA LINFOBLÁSTICA AGUDA ANTES DEL TRATAMIENTO ANTINEOPLÁSICO

    Directory of Open Access Journals (Sweden)

    Jeél Moya S

    2015-12-01

    Full Text Available Objective: To determine the enzymatic biochemical parameters (glutamic pyruvic transaminase (ALT, glutamic oxaloacetic transaminase (AST, alkaline phosphatase (ALP, gamma glutamyltransferase (γ-GT, and lactate dehydrogenase (LDH in children with acute lymphoblastic leukemia (ALL before cancer treatment. Material and Methods: A prospective experimental, observational, cross-sectional study was conducted in 30 children between 2 and 15 years old, from several Neoplastic Centers in Lima. Blood collection was performed in BD red cap Vacutainer tubes, processed in the semi-automated analyzer BIOTEC® EMP-168, with Wiener Lab Group enzyme reagents under the modified method Szaaz and UV-Optimized by IFCC, SSCC and SFBC. Finally, coding and tabulation was performed. Results: 60% were boys and 46.7% are between the ages of 2-6 years. Serum levels of AST were increased by 33.3% in boys and 50% in girls. Serum ALT values were increased in 33.3% of boys and 41.7% of girls; only 25% of girls showed increased levels of γ-GT values; ALP was increased in 44.4% of boys and 66.7% of girls. Moreover LDH levels were increased in 55.6% of boys and 41.7% of girls. Conclusions: The enzymatic tests LDH, AST, ALT and ALP are increased in children with ALL compared to normal values due to tumor lysis syndrome characterized by electrolyte abnormalities, and as a result of the massive destruction of tumor cells and rapid release of large amounts of intracellular elements.

  15. A Hannibal's Treck Across The Alps: Geomorphological Analysis Of Sites Of Geoarchaeologicals Interest

    Science.gov (United States)

    Mahaney, William C.; Kalm, Volli; Dirszowsky, Randy W.; Milner, Michael W.; Sodhi, Rana; Beukens, Roelf; Dorn, Ron; Tricart, Pierre; Schwartz, Stéphane; Chamorro-Perez, Eva; Boccia, Sal; Barendregt, René W.; Krinsley, D. H.; Seaquist, E. R.; Merrick, David; Kapran, Barbara

    A ~2200 year-old question related to Hannibal's invasion route across the Alps into Italia, has been argued by classicists without recovery of material evidence. A comparison of topographical descriptions in the ancient literature with environmental parameters in the Alps, attempted here for the first time, provides a database against which various pathways can be assessed. Identification of sites using geological, geomorphological, astronomical, chemical and petrological methods leads to the exclusion of certain transit points and targeting of others where geoarchaeological excavation might yield important evidence related to the military culture of ancient Carthage.

  16. End of the Little Ice Age in the Alps forced by industrial black carbon

    OpenAIRE

    Painter, Thomas H.; Flanner, Mark G.; Kaser, Georg; Marzeion, Ben; VanCuren, Richard A.; Abdalati, Waleed

    2013-01-01

    The end of the Little Ice Age in the European Alps has long been a paradox to glaciology and climatology. Glaciers in the Alps began to retreat abruptly in the mid-19th century, but reconstructions of temperature and precipitation indicate that glaciers should have instead advanced into the 20th century. We observe that industrial black carbon in snow began to increase markedly in the mid-19th century and show with simulations that the associated increases in absorbed sunlight by black carbon...

  17. Cushing syndrome

    Science.gov (United States)

    Hypercortisolism; Cortisol excess; Glucocorticoid excess - Cushing syndrome ... The most common cause of Cushing syndrome is taking too much ... Cushing syndrome . Prednisone, dexamethasone, and prednisolone ...

  18. LEOPARD syndrome

    Science.gov (United States)

    Multiple lentigines syndrome; Noonan syndrome with multiple lentigines ... Genetics Home Reference -- ghr.nlm.nih.gov/condition/noonan-syndrome-with-multiple-lentigines National Organization for Rare Disorders -- ...

  19. Outpatient management of steroid-induced hyperglycaemia and steroid-induced diabetes in people with lymphoproliferative disorders treated with intermittent high dose steroids

    Directory of Open Access Journals (Sweden)

    Jennifer Vidler

    2017-09-01

    Eighty-three people were diagnosed with a lymphoproliferative disorder, of whom 6 had known Type 2 diabetes. Fifty-three people without known diabetes were screened by HbA1c and random venous plasma glucose. All patients (n = 34 subsequently prescribed HDS checked capillary blood glucose (CBG pre-breakfast and pre-evening meal. Treatment algorithms used initiation and/or dose titration of gliclazide or human NPH insulin, aiming for pre-meal CBG 5–11 mmol/l. Type 2 diabetes was identified in 4/53 people screened (7.5%. Of 34 people treated with HDS, 17 (44% developed SIH/SID. All 7 people with Type 2 diabetes developed SIH and 3 required insulin. Of 27 people without known diabetes, 8 (30% developed SID and 1 required insulin. Pre-treatment HbA1c was higher in people who developed SID compared to those that did not (p = 0.002. This is the first report of a SID/SIH detection and treatment protocol for use in people with lymphoproliferative disorders receiving intermittent HDS, demonstrating its feasibility and safety.

  20. Orbital benign and malignant lymphoproliferative disorders: Differentiation using semi-quantitative and quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging

    International Nuclear Information System (INIS)

    Hu, Hao; Xu, Xiao-Quan; Liu, Hu; Hong, Xun-Ning; Shi, Hai-Bin; Wu, Fei-Yun

    2017-01-01

    Objectives: To assess the value of dynamic contrast-enhanced MR imaging (DCE-MRI) in differentiating benign from malignant orbital lymphoproliferative disorders (OLPDs). Methods: Thirty-nine patients with orbital lymphoproliferative disorders (21 malignant and 18 benign) underwent DCE-MRI scan for pre-treatment evaluation from March 2013 to December 2015. Both semi-quantitative (TTP, AUC, Slope max ) and quantitative (K trans , k ep , v e ) parameters were calculated, and compared between two groups. Receiver operating characteristic (ROC) curve analyses were used to determine the diagnostic value of each significant parameter. Results: Malignant OLPDs showed significantly higher k ep , lower v e , and lower AUC than benign OLPDs, while no significant differences were found on K trans , TTP and Slope max . ROC analyses indicated that v e exhibited the best diagnostic performance in predicting malignant OLPDs (cutoff value, 0.211; area under the curve, 0.896; sensitivity, 76.2%; specificity, 94.9%), followed by k ep (cutoff value, 0.853; area under the curve, 0.839; sensitivity, 85.7%; specificity, 89.9%). Conclusion: DCE-MRI and specially its derived quantitative parameters of k ep and v e are promising metrics for differentiating malignant from benign OLPDs.

  1. Orbital benign and malignant lymphoproliferative disorders: Differentiation using semi-quantitative and quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Hao; Xu, Xiao-Quan [Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing (China); Liu, Hu [Department of Ophthalmology, First Affiliated Hospital of Nanjing Medical University, Nanjing (China); Hong, Xun-Ning; Shi, Hai-Bin [Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing (China); Wu, Fei-Yun, E-mail: wfydd_njmu@163.com [Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing (China)

    2017-03-15

    Objectives: To assess the value of dynamic contrast-enhanced MR imaging (DCE-MRI) in differentiating benign from malignant orbital lymphoproliferative disorders (OLPDs). Methods: Thirty-nine patients with orbital lymphoproliferative disorders (21 malignant and 18 benign) underwent DCE-MRI scan for pre-treatment evaluation from March 2013 to December 2015. Both semi-quantitative (TTP, AUC, Slope{sub max}) and quantitative (K{sup trans}, k{sub ep}, v{sub e}) parameters were calculated, and compared between two groups. Receiver operating characteristic (ROC) curve analyses were used to determine the diagnostic value of each significant parameter. Results: Malignant OLPDs showed significantly higher k{sub ep}, lower v{sub e}, and lower AUC than benign OLPDs, while no significant differences were found on K{sup trans}, TTP and Slope{sub max}. ROC analyses indicated that v{sub e} exhibited the best diagnostic performance in predicting malignant OLPDs (cutoff value, 0.211; area under the curve, 0.896; sensitivity, 76.2%; specificity, 94.9%), followed by k{sub ep} (cutoff value, 0.853; area under the curve, 0.839; sensitivity, 85.7%; specificity, 89.9%). Conclusion: DCE-MRI and specially its derived quantitative parameters of k{sub ep} and v{sub e} are promising metrics for differentiating malignant from benign OLPDs.

  2. Fanconi syndrome

    Science.gov (United States)

    De Toni-Fanconi syndrome ... Fanconi syndrome can be caused by faulty genes, or it may result later in life due to kidney damage. Sometimes the cause of Fanconi syndrome is unknown. Common causes of Fanconi syndrome in ...

  3. Duane Syndrome

    Science.gov (United States)

    ... Frequently Asked Questions Español Condiciones Chinese Conditions Duane Syndrome En Español Read in Chinese What is Duane Syndrome? Duane syndrome, also called Duane retraction syndrome (DRS), ...

  4. Effects of atmospheric and climate change at the timberline of the Central European Alps

    Science.gov (United States)

    Wieser, Gerhard; Matyssek, Rainer; Luzian, Roland; Zwerger, Peter; Pindur, Peter; Oberhuber, Walter; Gruber, Andreas

    2011-01-01

    This review considers potential effects of atmospheric change and climate warming within the timberline ecotone of the Central European Alps. After focusing on the impacts of ozone (O3) and rising atmospheric CO2 concentration, effects of climate warming on the carbon and water balance of timberline trees and forests will be outlined towards conclusions about changes in tree growth and treeline dynamics. Presently, ambient ground-level O3 concentrations do not exert crucial stress on adult conifers at the timberline of the Central European Alps. In response to elevated atmospheric CO2 Larix decidua showed growth increase, whereas no such response was found in Pinus uncinata. Overall climate warming appears as the factor responsible for the observed growth stimulation of timberline trees. Increased seedling re-establishment in the Central European Alps however, resulted from invasion into potential habitats rather than upward migration due to climate change, although seedlings will only reach tree size upon successful coupling with the atmosphere and thus loosing the beneficial microclimate of low stature vegetation. In conclusion, future climate extremes are more likely than the gradual temperature increase to control treeline dynamics in the Central European Alps. PMID:21379395

  5. Shear in the tethys and the permian paleomagnetism in the Southern Alps, including new results

    NARCIS (Netherlands)

    Zijderveld, J.D.A.; Hazeu, G.J.A.; Nardin, M.; Voo, R. van der

    1970-01-01

    To verify paleomagnetic proof for megatectonic translation in the Tethys a large collection of samples from a key area, the Bolzano Quartz Porphyry Plateau in the Southern Alps, was examined. Their natural remanent magnetization was analyzed with thermal, and mainly alternating field

  6. Relationship between Arm Span Measurements and Body Height in Dinaric Alpes Population: a Systematic Review

    Directory of Open Access Journals (Sweden)

    Bojan Masanovic

    2017-08-01

    Full Text Available Several researches have reported the benefit of using various body parameters in predicting standing height, and arm span happened to be one of the most reliable ones in adults. On the other hand, it is well-known the tallness and body proportions are specific in the area that are covered by Dinaric Alpes. Therefore, the purpose of this study was to investigate the potential relationship between arm span measurements and body height in Dinaric Alpes population. The most visible electronic database (Google Scholar was searched for original research articles available until September 2017. Then research findings were summarized and relationship between arm span measurements and body height in Dinaric Alpes population were identified, as well as areas of future research were recommended. The assessment of body height using various anthropometric measures is very typical from the past centuries and it has been attempted to be studied by many researchers. However, it is important to underline that the arm span has been obtained as the most reliable body indicator for predicting the true height of an individual. However, the studies sampled with the populations lived at Dinaric Alpes mountains have specific estimates. Therefore, all above-mentioned have confirmed the necessity for developing separate body height models for each population on account of ethnic as well as regional differences.

  7. Retrograde mineral and fluid evolution in high-pressure metapelites (Schistes Lustres unit, Western Alps).

    NARCIS (Netherlands)

    Agard, Ph.; Goffe, B.; Touret, J.L.R.; Vidal, O.

    2000-01-01

    Fluid inclusions have been analysed in successive generations of syn-metamorphic segregations within low-grade, high-pressure, low-temperature (HP-LT) metapelites from the Western Alps. Fluid composition was then compared to mass transfer deduced from outcrop-scale retrograde mineral reactions. Two

  8. Possible thermal structure of the eastern part of the central Alps

    International Nuclear Information System (INIS)

    Pasquale, U.

    1987-01-01

    The trend of temperature in respect of depth in lithosphere under the eastern part of the Central Alps between Innsbruck and Graz, using a geothermal model based on the reduced heat production along the vertical and on the thermal conductivity dependence upon temperature and pressure is studied. A linear relationship has been found between the reduced heat flow and the mean surface heat flow

  9. The geology of the Vicentinian Alps (NE-Italy) : (with special reference to their paleomagnetic history)

    NARCIS (Netherlands)

    Boer, J. de

    1963-01-01

    This geological study on the Vicentinian Alps is mainly an analysis of the tectonic and paleomagnetic data, collected by the author in the years 1959, 1960, and 1961. The stratigraphy is based for the greater part on data published in the first decenniums of this century. In the

  10. The geology of the Vicentinian Alps (NE-Italy) : (with special reference to their paleomagnetic history)

    NARCIS (Netherlands)

    de Boer, J.

    1963-01-01

    This geological study on the Vicentinian Alps is mainly an analysis of the tectonic and paleomagnetic data, collected by the author in the years 1959, 1960, and 1961. The stratigraphy is based for the greater part on data published in the first decenniums of this century. In the westtern part of the

  11. The geology of the Vicentinian Alps (NE-Italy) : with special reference to their paleomagnetic history

    NARCIS (Netherlands)

    Boer, Jelle de

    1963-01-01

    This geological study on the Vicentinian Alps is mainly an analysis of the tectonic and paleomagnetic data, collected by the author in the years 1959, 1960, and 1961. The stratigraphy is based for the greater part on data published in the first decenniums of this century. In the

  12. Permafrost distribution in the European Alps: calculation and evaluation of an index map and summary statistics

    Directory of Open Access Journals (Sweden)

    L. Boeckli

    2012-07-01

    Full Text Available The objective of this study is the production of an Alpine Permafrost Index Map (APIM covering the entire European Alps. A unified statistical model that is based on Alpine-wide permafrost observations is used for debris and bedrock surfaces across the entire Alps. The explanatory variables of the model are mean annual air temperatures, potential incoming solar radiation and precipitation. Offset terms were applied to make model predictions for topographic and geomorphic conditions that differ from the terrain features used for model fitting. These offsets are based on literature review and involve some degree of subjective choice during model building. The assessment of the APIM is challenging because limited independent test data are available for comparison and these observations represent point information in a spatially highly variable topography. The APIM provides an index that describes the spatial distribution of permafrost and comes together with an interpretation key that helps to assess map uncertainties and to relate map contents to their actual expression in the terrain. The map can be used as a first resource to estimate permafrost conditions at any given location in the European Alps in a variety of contexts such as research and spatial planning.

    Results show that Switzerland likely is the country with the largest permafrost area in the Alps, followed by Italy, Austria, France and Germany. Slovenia and Liechtenstein may have marginal permafrost areas. In all countries the permafrost area is expected to be larger than the glacier-covered area.

  13. Spectrum and immunophenotyping of 653 patients with B-cell chronic lymphoproliferative disorders in China: A single-centre analysis.

    Science.gov (United States)

    Miao, Yi; Cao, Lei; Sun, Qian; Li, Xiao-Tong; Wang, Yan; Qiao, Chun; Wang, Li; Wang, Rong; Qiu, Hai-Rong; Xu, Wei; Li, Jian-Yong; Wu, Yu-Jie; Fan, Lei

    2018-02-01

    The incidence of B-cell chronic lymphoproliferative disorders (B-CLPDs) is significantly lower in China than that in western countries. There have been studies involving small cohorts with conflicting results regarding the spectrum of B-CLPDs in China, and the types and immunophenotyping of B-CLPDs in China remain largely unexplored. We conducted a retrospective analysis of 653 cases of B-CLPDs seen in our centre from 2011 to 2015. Four-colour flow cytometry was used to determine the expression of each immunological marker, and the diagnostic values of the immunological markers were also investigated. Chronic lymphocytic leukaemia (CLL) was the most common type of B-CLPD, which was consistent with that in west countries. However, the proportions of CLL (55.9%), follicular lymphoma (2.6%), and hairy cell leukaemia (0.2%) were lower, while the proportion of lymphoplasmacytic lymphoma/WaldenstrÖm macroglobulinaemia (5.4%) was higher in China, as compared with western countries. With respect to immunophenotypic characteristics, CD23 (31.7%) was more frequently expressed in mantle cell lymphoma (MCL) in our cohort than that in western countries. Immunophenotyping was useful in differentiating MCL from CLL or B-cell prolymphocytic leukaemia and lymphoplasmacytic lymphoma/WaldenstrÖm macroglobulinaemia from splenic marginal zone lymphoma. CD200 was of better diagnostic performance (accuracy: 94.6%) in differentiating CLL from MCL compared with CD23 (accuracy: 93.3%). Some cases of B-CPLDs, however, had no definite diagnoses, which were diagnosed as CD5 + B-CPLDs unclassified (7.7%) and CD5 - B-CPLDs unclassified (15.8%). This is the largest study that systematically explores the spectrum and immunophenotyping of B-CLPDs in Asia, confirming that spectrum of B-CLPDs in China was different from that in western countries. The immunophenotypic features of B-CLPDs were similar between China and western countries, although a few disparities exist. Cases with no definite

  14. POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS: ROLE OF VIRAL INFECTION, GENETIC LESIONS AND ANTIGEN STIMULATION IN THE PATHOGENESIS OF THE DISEASE

    Directory of Open Access Journals (Sweden)

    Gianluca Gaidano

    2009-11-01

    Full Text Available

    Post-transplant lymphoproliferative disorders (PTLD are a life-threatening complication of solid organ transplantation or, more rarely, hematopoietic stem cell transplantation. The majority of PTLD is of B-cell origin and associated with Epstein–Barr virus (EBV infection. PTLD generally display involvement of extranodal sites, aggressive histology and aggressive clinical behavior. The molecular pathogenesis of PTLD involves infection by oncogenic viruses, namely Epstein-Barr virus, as well as genetic or epigenetic alterations of several cellular genes. At variance with lymphoma arising in immunocompetent hosts, whose genome is relatively stable, a fraction of PTLD are characterized by microsatellite instability as a consequence of defects in the DNA mismatch repair mechanism. Apart from microsatellite instability, molecular alterations of cellular genes recognized in PTLD include alterations of cMYC, BCL6, TP53, DNA hypermethylation, and aberrant somatic hypermutation of protooncogenes. The occurrence of IGV mutations in the overwhelming majority of PTLD documents that malignant transformation targets germinal centre (GC B-cells and their descendants both in EBV–positive and EBV–negative cases. Analysis of phenotypic markers of B-cell histogenesis, namely BCL6, MUM1 and CD138, allows further distinction of PTLD histogenetic categories. PTLD expressing the BCL6+/MUM1+/-/CD138- profile reflect B-cells actively experiencing the GC reaction, and comprise diffuse large B-cell lymphoma (DLBCL centroblastic and Burkitt lymphoma. PTLD expressing the BCL6-/MUM1+/CD138- phenotype putatively derive from B-cells that have concluded the GC reaction, and comprise the majority of polymorphic PTLD and a fraction of

  15. PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment

    International Nuclear Information System (INIS)

    Singh, Alok R.; Peirce, Susan K.; Joshi, Shweta; Durden, Donald L.

    2014-01-01

    kinase inhibitors reverse the lymphoproliferative phenotype in vivo. - Highlights: • First genetic evidence that PTEN controls LPS/TLR4 signaling in B lymphocytes. • Evidence that PTEN regulates LPS induced lymphoproliferation in vivo. • PI-3 kinase inhibitors block LPS induced lymphoproliferation in vivo

  16. PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Alok R. [UCSD Department of Pediatrics, Moores UCSD Cancer Center, University of California School of Medicine, San Diego, CA 92093 (United States); Peirce, Susan K. [Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (United States); Joshi, Shweta [UCSD Department of Pediatrics, Moores UCSD Cancer Center, University of California School of Medicine, San Diego, CA 92093 (United States); Durden, Donald L., E-mail: ddurden@ucsd.edu [UCSD Department of Pediatrics, Moores UCSD Cancer Center, University of California School of Medicine, San Diego, CA 92093 (United States); Division of Pediatric Hematology-Oncology, UCSD Rady Children' s Hospital, La Jolla, CA (United States)

    2014-09-10

    -3 kinase inhibitors reverse the lymphoproliferative phenotype in vivo. - Highlights: • First genetic evidence that PTEN controls LPS/TLR4 signaling in B lymphocytes. • Evidence that PTEN regulates LPS induced lymphoproliferation in vivo. • PI-3 kinase inhibitors block LPS induced lymphoproliferation in vivo.

  17. Last Glacial Maximum Dated by Means of 10Be in the Maritime Alps (Italy)

    Science.gov (United States)

    Granger, D. E.; Spagnolo, M.; Federici, P.; Pappalardo, M.; Ribolini, A.; Cyr, A. J.

    2006-12-01

    Relatively few exposure dates of LGM moraines boulders are available for the European Alps, and none on the southern flank. Ponte Murato (PM) is a frontal moraine at 860 m asl in the Gesso Basin (Maritime Alps, SW European Alps). The PM moraine dams the 157 km2 Gesso della Barra Valley and it represents the lowermost frontal moraine of the entire Gesso Valley, near the outlet of the valley in the Po Plain. Its ELA, determined from the paleo- shape of the supposed Gesso della Barra glacier, is 1746 m asl. Tetti Bandito (TB) is a small and badly preserved glacial deposit, tentatively attributed to a lateral-frontal moraine, that is positioned 5 km downvalley from the PM deposit at 800 m asl. There are no other glacial deposits downvalley from the TB moraine in the Gesso Basin or farther NE in the piedmont region of the upper Po Plain. Boulders sampled on the PM and on the TB moraine crests gave a 10Be cosmogenic age of respectively 16300 ± 880 ka (average value) and 18798 ± 973 ka. This result constrains the PM frontal moraine within the LGM interval but also suggests that the maximum expansion of the Gesso Basin glacier was more downvalley at some point during the last glaciation. If the TB is a lateral-frontal moraine as supposed, the two TB and PM moraines would represent the outer and inner moraine crests of the same LGM stadial, with the outer moraine much less pronounced than the inner moraine, similarly to the maximalstand and the hochstand described in the Eastern Alps (Van Husen, 1997). Within this perspective, the PM and TB dates are consistent with a European Alps LGM corresponding to MIS 2 (Ivy-Ochs et al., 2004). This study of the Maritime Alps moraines is also in agreement with the Upper Würm climatic theory (Florineth and Schlüchter, 2000) of a stronger influence of the W and SW incoming humid airflows in the European Alps, differently from the nearby Vosges and Pyrenees mountain chains where more dry conditions were probably responsible for a very

  18. The cryogenic photon detection system for the ALPS II experiment. Characterization, optimization and background rejection

    International Nuclear Information System (INIS)

    Bastidon, Noemi Alice Chloe

    2017-01-01

    The search for new fundamental bosons at very low mass is the central objective of the ALPS II experiment which is currently set up at the Deutsches Elektronen-Synchrotron (DESY, Hamburg). This experiment follows the light-shining-through-the-wall concept where photons could oscillate into weakly interacting light bosons in front of a wall and back into photons behind the wall, giving the impression that light can shine through a light tight barrier. In this concept, the background-free detection of near-infrared photons is required to fully exploit the sensitivity of the apparatus. The high efficiency single-photon detection in the near-infrared is challenging and requires a cryogenic detector. In this project, a Transition-Edge Sensor (TES) operated below 100mK will be used to detect single photons. This thesis focuses on the characterization and optimization of the ALPS II detector system including an Adiabatic Demagnetisation Refrigerator (ADR) with its two-stage pulse-tube cooler, two TES detectors and their Superconducting Quantum Interference Devices (SQUIDs) read-out system. Stability of the detection system over time is a priority in the ALPS II experiment. It is in this context that the cooling system has been subjected to many upgrades. In the framework of this thesis, the cooling setup has been studied in detail in order to optimize its cooling performances. Furthermore, the stability of the detector has been studied according to various criteria. Other essential parameters of the ALPS II experiment are its detection efficiency and its background rate. Indeed, the sensitivity of the experiment directly depends on these two characteristics. Both elements have been studied in depth in order to define if the chosen TES detector will meet ALPS IIc specifications.

  19. The European Alps as an interrupter of the Earth's conductivity structures

    Science.gov (United States)

    Al-Halbouni, D.

    2013-07-01

    Joint interpretation of magnetotelluric and geomagnetic depth sounding results in the period range of 10-105 s in the Western European Alps offer new insights into the conductivity structure of the Earth's crust and mantle. This first large scale electromagnetic study in the Alps covers a cross-section from Germany to northern Italy and shows the importance of the alpine mountain chain as an interrupter of continuous conductors. Poor data quality due to the highly crystalline underground is overcome by Remote Reference and Robust Processing techniques and the combination of both electromagnetic methods. 3-D forward modeling reveals on the one hand interrupted dipping crustal conductors with maximum conductances of 4960 S and on the other hand a lithosphere thickening up to 208 km beneath the central Western Alps. Graphite networks arising from Palaeozoic sedimentary deposits are considered to be accountable for the occurrence of high conductivity and the distribution pattern of crustal conductors. The influence of huge sedimentary Molasse basins on the electromagnetic data is suggested to be minor compared with the influence of crustal conductors. Dipping direction (S-SE) and maximum angle (10.1°) of the northern crustal conductor reveal the main thrusting conditions beneath the Helvetic Alps whereas the existence of a crustal conductor in the Briançonnais supports theses about its belonging to the Iberian Peninsula. In conclusion the proposed model arisen from combined 3-D modeling of noise corrected electromagnetic data is able to explain the geophysical influence of various structural features in and around the Western European Alps and serves as a background for further upcoming studies.

  20. SKS splitting results in central Italy and Dinaric region inside the AlpArray-CASE project

    Science.gov (United States)

    Salimbeni, S.; Prevolnik, S.; Pondrelli, S.; Molinari, I.; Stipcevic, J.; Kissling, E.; Šipka, V.; Herak, M.

    2017-12-01

    In the framework of the AlpArray project (AlpArray Seismic Network, 2015), the complementary "Central Adriatic Seismic Experiment" (CASE; AlpArray Seismic Network, 2016) was established as collaboration between ETH Zürich, University of Zagreb, INGV and Republic Hydrometeorological Service of Republic of Srpska. The CASE project consists of 9 temporary stations, installed in October 2016, located in Bosnia and Herzegovina, Croatia and Italy. Temporary broadband seismic stations, with the permanent stations present in the region shared by the Croatian Seismological Service and INGV, make an almost continuous transect cutting the Central-Southern Appenines, the central Adriatic region, central External Dinarides and finishing at the eastern margin of the Internal Dinarides. The presence of the the Apenninic and Dinarides slabs, verging in opposite directions and plunging along the opposite sides of the Adriatic plate, make this area a peculiar spot to understand the complex dynamic of the region. Various tomographic images (e.g. Bijwaard and Spakman, 2000; Piromallo and Morelli, 2003) shows not continuous slabs under the Appenines and the Dinarides, suggesting the presence of slab-gaps right beneath the region covered by the CASE experiment. Here we present the preliminary results of the SKS splitting analysis performed on the data recorded by the temporary and permanent seismic stations included in the CASE project. The new results, in combination with previous interpretation, will provide clues about how Northern and Southern Apennines are connected at depth, how the slab rollback of the Apennines thrust belt acted and if and how the Apennines are in relation with the Dinaric region. Together with the measurements from previous studies and from the AlpArray project, our new data will support the mapping of the seismic anisotropy deformation pattern from Western Alps to Pannonian region.

  1. The cryogenic photon detection system for the ALPS II experiment. Characterization, optimization and background rejection

    Energy Technology Data Exchange (ETDEWEB)

    Bastidon, Noemi Alice Chloe

    2017-01-12

    The search for new fundamental bosons at very low mass is the central objective of the ALPS II experiment which is currently set up at the Deutsches Elektronen-Synchrotron (DESY, Hamburg). This experiment follows the light-shining-through-the-wall concept where photons could oscillate into weakly interacting light bosons in front of a wall and back into photons behind the wall, giving the impression that light can shine through a light tight barrier. In this concept, the background-free detection of near-infrared photons is required to fully exploit the sensitivity of the apparatus. The high efficiency single-photon detection in the near-infrared is challenging and requires a cryogenic detector. In this project, a Transition-Edge Sensor (TES) operated below 100mK will be used to detect single photons. This thesis focuses on the characterization and optimization of the ALPS II detector system including an Adiabatic Demagnetisation Refrigerator (ADR) with its two-stage pulse-tube cooler, two TES detectors and their Superconducting Quantum Interference Devices (SQUIDs) read-out system. Stability of the detection system over time is a priority in the ALPS II experiment. It is in this context that the cooling system has been subjected to many upgrades. In the framework of this thesis, the cooling setup has been studied in detail in order to optimize its cooling performances. Furthermore, the stability of the detector has been studied according to various criteria. Other essential parameters of the ALPS II experiment are its detection efficiency and its background rate. Indeed, the sensitivity of the experiment directly depends on these two characteristics. Both elements have been studied in depth in order to define if the chosen TES detector will meet ALPS IIc specifications.

  2. Hamartomatous polyposis syndromes

    DEFF Research Database (Denmark)

    Jelsig, Anne Marie; Qvist, Niels; Brusgaard, Klaus

    2014-01-01

    Hamartomatous Polyposis Syndromes (HPS) are genetic syndromes, which include Peutz-Jeghers syndrome, Juvenile polyposis syndrome, PTEN hamartoma tumour syndrome (Cowden Syndrom, Bannayan-Riley-Ruvalcaba and Proteus Syndrome) as well as hereditary mixed polyposis syndrome. Other syndromes such as ......Hamartomatous Polyposis Syndromes (HPS) are genetic syndromes, which include Peutz-Jeghers syndrome, Juvenile polyposis syndrome, PTEN hamartoma tumour syndrome (Cowden Syndrom, Bannayan-Riley-Ruvalcaba and Proteus Syndrome) as well as hereditary mixed polyposis syndrome. Other syndromes...

  3. Liver enzymes and markers of inflammation in Nigerian adults with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Udenze Ifeoma Christiana

    2015-01-01

    Full Text Available Aims and objectives: The aim of this study is to determine the plasma levels of the liver enzymes alanine aminotransferase (ALT, aspartate aminotransferase (AST, alkaline phosphatase (ALP, gamma-glutamyl transferase (GGT, and lactate dehydrogenase (LDH in people with metabolic syndrome and to determine the association between the liver enzymes and obesity, insulin resistance, interleukin 6 (IL-6, and C-reactive protein (CRP in adult Nigerians with metabolic syndrome. Materials and Methods: This was a case control study of 50 adult men and women with metabolic syndrome, and 50 age- and sex-matched males and females without metabolic syndrome. Metabolic syndrome was defined based on the National Cholesterol Education Program (NCEP-Adult Treatment Panel III (ATPIII criteria. Written informed consent was obtained from the participants. Sociodemographic and clinical data were collected using a structured questionnaire. Venous blood was collected after an overnight fast. The ethics committee of the Lagos University Teaching Hospital in Lagos, Nigeria, approved the study protocol. Comparison of continuous variables was done using the student′s t-test. Regression and correlation analysis were used to determine the associations between variables. Statistical significance was set at P < 0.05. Results: There was a statistically significant increase in the liver enzymes ALP (P = 0.031, ALT (P = 0.019, and GGT (P = 0.037, as well as in the inflammatory markers CRP (P = 0.019 and the cytokine IL-6 (P = 0.040 between the two study groups. ALP and ALT showed significant correlation with waist circumference, BMI, fasting insulin, and waist/hip ratio (P < 0.05. Multivariate regression also identified ALT, AST, and ALP to be associated with IL-6 and CRP (P < 0.05. Conclusion: Liver enzyme levels were increased in metabolic syndrome and associated with obesity, fasting insulin, and CRP. Elevated liver enzymes may indicate dysmetabolism and increased

  4. Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation (SCT) and quantitatively predicts EBV-lymphoproliferative disease following T-cell--depleted SCT

    NARCIS (Netherlands)

    van Esser, J W; van der Holt, B; Meijer, E; Niesters, H G; Trenschel, R; Thijsen, S F; van Loon, A M; Frassoni, F; Bacigalupo, A; Schaefer, U W; Osterhaus, A D; Gratama, J W; Löwenberg, B; Verdonck, L F; Cornelissen, J J

    2001-01-01

    Reactivation of the Epstein-Barr virus (EBV) after allogeneic stem cell transplantation (allo-SCT) may evoke a protective cellular immune response or may be complicated by the development of EBV-lymphoproliferative disease (EBV-LPD). So far, very little is known about the incidence, recurrence, and

  5. Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment

    NARCIS (Netherlands)

    Bekkenk, M. W.; Geelen, F. A.; van Voorst Vader, P. C.; Heule, F.; Geerts, M. L.; van Vloten, W. A.; Meijer, C. J.; Willemze, R.

    2000-01-01

    To evaluate our diagnostic and therapeutic guidelines, clinical and long-term follow-up data of 219 patients with primary or secondary cutaneous CD30(+) lymphoproliferative disorders were evaluated. The study group included 118 patients with lymphomatoid papulosis (LyP; group 1), 79 patients with

  6. Rapid evolution of the Helicobacter pylori AlpA adhesin in a high gastric cancer risk region from Colombia

    Directory of Open Access Journals (Sweden)

    Andrés Julián Gutiérrez-Escobar

    2018-05-01

    Full Text Available To be able to survive, Helicobacter pylori must adhere to the gastric epithelial cells of its human host. For this purpose, the bacterium employs an array of adhesins, for example, AlpA. The adhesin AlpA has been proposed as a major adhesin because of its critical role in human stomach colonization. Therefore, understanding how AlpA evolved could be important for the development of new diagnostic strategies. However, the genetic variation and microevolutionary patterns of alpA have not been described in Colombia. The study aim was to describe the variation patterns and microevolutionary process of alpA in Colombian clinical isolates of H. pylori. The existing polymorphisms, which are deviations from the neutral model of molecular evolution, and the genetic differentiation of the alpA gene from Colombian clinical isolates of H. pylori were determined. The analysis shows that gene conversion and purifying selection have shaped the evolution of three different variants of alpA in Colombia.

  7. Effect of Al and AlP on the microstructure of Mn-30 wt.%Si alloy

    Energy Technology Data Exchange (ETDEWEB)

    Wu Yuying [Key Laboratory of Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University, Jing Shi Road 73, Jinan 250061 (China); Liu Xiangfa [Key Laboratory of Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University, Jing Shi Road 73, Jinan 250061 (China)], E-mail: xfliu@sdu.edu.cn

    2008-04-15

    Effect of Al and AlP particles on the microstructure of near eutectic Mn-Si alloy (Mn-30 wt.%Si) was studied by Electron Probe Micro-analyzer (EPMA) and Differential Scanning Calorimeter (DSC). Crystal lattice correspondence analyses show that both Al and AlP have good lattice matching coherence relationships with MnSi phase, and the addition of Al and AlP particles results in an abnormal eutectic structure, i.e. the eutectic constitution MnSi and Mn{sub 5}Si{sub 3} precipitate separately: MnSi precipitates firstly, and then the Mn{sub 5}Si{sub 3} phase.

  8. End of the "Little Ice Age" in the Alps not forced by industrial black carbon

    Science.gov (United States)

    Sigl, Michael; Osmont, Dimtri; Gabrieli, Jacopo; Barbante, Carlo; Schwikowski, Margit

    2016-04-01

    Light absorbing aerosols present in the atmosphere and cryosphere play an important role in the climate system. Their presence in ambient air and snow changes radiative properties of these media, thus contributing to increased atmospheric warming and snowmelt. High spatio-temporal variability of aerosol concentrations in these media and a shortage of long-term observations contribute to large uncertainties in properly assigning the climate effects of these aerosols through time. Glaciers in the European Alps began to retreat abruptly from their mid-19th century maximum, marking what appeared to be the end of the Little Ice Age. Radiative forcing by increasing deposition of industrial black carbon to snow has been suggested as the main driver of the abrupt glacier retreats in the Alps (Painter et al. 2012). Basis for this hypothesis were model simulations using ice-core measurements of elemental carbon at low temporal resolution from two ice cores in the Alps. Here we present sub-annually resolved, well replicated ice-core measurements of refractory black carbon (rBC; using a SP2 soot photometer), mineral dust (Fe, Ca), biomass burning (NH4, K) and distinctive industrial pollution tracers (Bi, Pb, SO4) from an ice core in the Alps covering the past 250 years. These reconstructions allow to precisely compare the timing of observed acceleration of glacier melt in the mid-19th century with that of the increase of soot deposition on ice-sheets caused by the industrialization of Western Europe. Our study suggests that at the time when European rBC emission rates started to significantly increase Alpine glaciers have already experienced more than 70% of their total 19th century length reduction. Industrial BC emissions can therefore not been considered as the primary forcing of the rapid deglaciation at the end of the Little Ice Age in the Alps. References: Painter, T. H., M. G. Flanner, G. Kaser, B. Marzeion, R. A. VanCuren, and W. Abdalati (2013), End of the Little Ice

  9. Desordem linfoproliferativa pós-transplante em paciente pediátrico Post-transplantation lymphoproliferative disorder in pediatric patient

    Directory of Open Access Journals (Sweden)

    Paulo Manuel Pêgo Fernandes

    2006-10-01

    Full Text Available Terapias de imunossupressão, a que pacientes transplantados devem ser submetidos, os expõe a um alto risco de desenvolver desordens linfoproliferativas pós-transplante (PTLD. Descrevemos o caso de uma criança submetida a transplante cardíaco aos sete meses de idade e que acabou desenvolvendo PTLD, aos nove anos, diagnosticada por meio de retirada de nódulo pulmonar.Immunosuppressive therapy for transplanted patients exposes them to a high risk of developing posttransplantation lymphoproliferative disorders (PTLD. We report the case of a child undergoing heart transplantation at seven months of age who developed PTLD at nine years of age, diagnosed by resection of a pulmonary nodule.

  10. Facial manifestations of Epstein-Barr virus-related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations.

    Science.gov (United States)

    Lu, Benjamin Y; Kojima, Lisa; Huang, Mary S; Friedmann, Alison M; Ferry, Judith A; Weinstein, Howard J

    2016-11-01

    Epstein-Barr virus-related lymphoproliferative disease (EBV-LPD) rarely occurs in patients with acute lymphoblastic leukemia (ALL), who have not received hematopoietic transplantation. We describe EBV-LPD manifesting as facial lesions in two children with ALL in remission. One patient was a 16-year-old male with T-cell ALL with an EBV-positive angiocentric polymorphous lip lesion presenting as right-sided facial swelling. The other patient was a 12-year-old male with B-cell ALL with an EBV-positive polymorphous lymphoplasmacytic infiltrate presenting as bilateral dacryoadenitis. Neither patient had known primary immunodeficiencies. Both cases improved with immunosuppressant de-escalation. These cases suggest that immunosuppression induced by maintenance chemotherapy is sufficient to promote EBV-LPD. © 2016 Wiley Periodicals, Inc.

  11. The role of antiviral and immunoglobulin therapy in the prevention of Epstein-Barr virus infection and post-transplant lymphoproliferative disease following solid organ transplantation.

    Science.gov (United States)

    Green, M; Reyes, J; Webber, S; Rowe, D

    2001-06-01

    The recognition of the importance of Epstein-Barr virus (EBV) infection, including EBV-associated post-transplant lymphoproliferative disease (PTLD), has led to a new focus on the prevention of this problem. This paper reviews the scientific rationale behind, and clinical experience with, the use of chemoprophylaxis (using acyclovir or ganciclovir) and immunoprophylaxis (using intravenous immunoglobulin) in the prevention of EBV/PTLD. While some centers have already introduced the use of one or both of these agents as standard prophylaxis against the development of this complication, published data in support of these protocols are currently lacking. Well designed clinical trials are necessary to evaluate the potential role of both antiviral and immunoglobulin agents in the prevention of EBV/PTLD in organ transplant recipients.

  12. Mammoths inside the Alps during the last glacial period: Radiocarbon constraints from Austria and palaeoenvironmental implications

    Science.gov (United States)

    Spötl, Christoph; Reimer, Paula J.; Göhlich, Ursula B.

    2018-06-01

    This study examines remains of the woolly mammoth (Mammuthus primigenius) found inside the Austrian Alps, an area occupied by an extensive ice-stream network during the Last Glacial Maximum. The data demonstrate that these cold steppe-adapted animals locally migrated several tens of kilometers into alpine valleys. Radiocarbon analyses constrain the age of these fossils to the first half of Marine Isotope Stage 3, documenting ice-free conditions in major valleys at that time. We also provide a list of all traceable Austrian sites of Mammuthus primigenius, totaling about 230 localities, compiled through 15 museums and collections in Austria. The vast majority of these findings are from the corridors of the Danube and Mur rivers and their tributaries and the adjacent loess-covered foreland of the Alps, areas that were never ice-covered during Pleistocene glaciations.

  13. Philorhizus occitanus sp. n. from the South-Western Alps (Piedmont, Italy (Coleoptera: Carabidae, Dromiini

    Directory of Open Access Journals (Sweden)

    Gianni Allegro

    2015-12-01

    Full Text Available Philorhizus occitanus sp. n. from the South-Western Alps (Ellero Valley and Maira Valley is described. This new species is similar to P. crucifer and P. notatus as far as the external morphology is concerned, but it is distinguished by the color pattern and the shape of elytra, as well as by the features of the median lobe of aedeagus. P. liguricus, which is easily distinguished from P. occitanus sp. n. by the external morphology, was already recorded from the South-Western Alps and from the Ligurian Apennines. P. occitanus sp. n. is a likely close relative of P. notatus, although the affinities of this relict flightless new species remain uncertain.

  14. Sensitivity of the French Alps snow cover to the variation of climatic variables

    Directory of Open Access Journals (Sweden)

    E. Martin

    Full Text Available In order to study the sensitivity of snow cover to changes in meteorological variables at a regional scale, a numerical snow model and an analysis system of the meteorological conditions adapted to relief were used. This approach has been successfully tested by comparing simulated and measured snow depth at 37 sites in the French Alps during a ten year data period. Then, the sensitivity of the snow cover to a variation in climatic conditions was tested by two different methods, which led to very similar results. To assess the impact of a particular "doubled CO2" scenario, coherent perturbations were introduced in the input data of the snow model. It was found that although the impact would be very pronounced, it would also be extremely differentiated, dependent on the internal state of the snow cover. The most sensitive areas are the elevations below 2400 m, especially in the southern part of the French Alps.

  15. Protracted fluid-induced melting during Barrovian metamorphism in the Central Alps

    DEFF Research Database (Denmark)

    Rubatto, Daniela; Hermann, Jörg; Berger, Alfons

    2009-01-01

    that repeated melting events occurred within a single Barrovian metamorphic cycle at roughly constant temperature; that in the country rocks zircon formation was limited to the initial stages of melting, whereas further melting concentrated in the segregated leucosomes; that melting occurred at different times......The timing and dynamics of fluid-induced melting in the typical Barrovian sequence of the Central Alps has been investigated using zircon chronology and trace element composition. Multiple zircon domains in leucosomes and country rocks yield U-Pb ages spanning from ~32 to 22 Ma. The zircon formed...... in samples a few meters apart because of the local rock composition and localized influx of the fluids; and that leucosomes were repeatedly melted when fluids became available. The geochronological data force a revision of the temperature-time path of the migmatite belt in the Central Alps. Protracted...

  16. 24th International Conference on Robotics in Alpe-Adria-Danube Region

    CERN Document Server

    2016-01-01

    This volume includes the Proceedings of the 24th International Conference on Robotics in Alpe-Adria-Danube Region, RAAD 2015, which was held in Bucharest, Romania, on May 27-29, 2015. The Conference brought together academic and industry researchers in robotics from the 11 countries affiliated to the Alpe-Adria-Danube space: Austria, Croatia, Czech Republic, Germany, Greece, Hungary, Italy, Romania, Serbia, Slovakia and Slovenia, and their worldwide partners. According to its tradition, RAAD 2015 covered all important areas of research, development and innovation in robotics, including new trends such as: bio-inspired and cognitive robots, visual servoing of robot motion, human-robot interaction, and personal robots for ambient assisted living. The accepted papers have been grouped in nine sessions: Robot integration in industrial applications; Grasping analysis, dexterous grippers and component design; Advanced robot motion control; Robot vision and sensory control; Human-robot interaction and collaboration;...

  17. T-Cell lymphoproliferative disorder of hand-mirror cell morphology presenting in an eosinophilic loculated peritoneal effusion, with omental "caking"

    Directory of Open Access Journals (Sweden)

    Tufankjian Dearon

    2006-01-01

    Full Text Available Abstract Background Cells with "hand mirror" morphology have not, to the best of our knowledge, been described in a primary effusion sample. This paper describes a case of T-cell lymphoma with eosinophilia in a patient with suspected peritoneal carcinomatosis. Rarely, a T-cell lymphoproliferative process may mimic primary peritoneal carcinomatosis, clinically suggested by a presentation in CT imaging of omental caking with bilateral massive loculated effusions in a patient without lymphadenopathy or splenomegaly. Methods A 60 year old caucasian male presented with vague abdominal discomfort and increasing abdominal girth. Computed tomography showed a two centimeter thick omental cake and a small loculated effusion. The clinical presentation and imaging findings were most consistent with peritoneal carcinomatosis. Cytologic evaluation of the effusion was undertaken for diagnostic study. Results Rapid intraprocedural interpretation of the effusion sample showed a monomorphic population of cells with "hand-mirror" cell morphology exhibiting cytoplasmic extensions (uropodia with 3–5 course dark cytoplasmic granules and a rim of vacuolated cytoplasm capping the opposing "mirror head" side. These cells were seen within a background of mature eosinophils. Flow cytometric evaluation of the ascites fluid demonstrated an atypical T-cell population with the following immunophenotype: CD2-, CD3+, CD4-, CD5-, CD7-, CD8+, CD56+. T-cell receptor (TCR gene rearrangement was positive for clonal TCR-gamma gene rearrangement, supporting the diagnosis of a T-lymphoprolifereative disorder. Conclusion A T-cell lymphoproliferative process may present with "hand mirror" morphology in an effusion sample. These cells may show polar cytoplasmic vacuolization and 3–5 course granules within the "handle" of these unique cells. Cytoplasm shows peripheral constriction around the nucleus.

  18. The species of the genus Diamesa (Diptera, Chironomidae) known to occur in Italian Alps and Apennines.

    Science.gov (United States)

    Montagna, Matteo; Urbanelli, Sandra; Rossaro, Bruno

    2016-11-15

    Some rare species from Italian Alps, belonging to the genus Diamesa Meigen, 1835 (Diptera, Chironomidae) are here redescribed as adult males, because only old, incomplete descriptions are available for these taxa. Terminology of male genitalia is reviewed, diagnostic features are illustrated in detail, and notes on biology and geographical distribution of the examined species are provided. An identification key to the known adult males is presented.

  19. Continuous micro-earthquake catalogue of the central Southern Alps, New Zealand

    Science.gov (United States)

    Michailos, Konstantinos; Townend, John; Savage, Martha; Chamberlain, Calum

    2017-04-01

    The Alpine Fault is one of the most prominent tectonic features in the South Island, New Zealand, and is inferred to be late in its seismic cycle of M 8 earthquakes based on paleoseismological evidence. Despite this, the Alpine Fault displays low levels of contemporary seismic activity, with little documented on-fault seismicity. This low magnitude seismicity, often below the completeness level of the GeoNet national seismic catalogue, may inform us of changes in fault character along-strike and might be used for rupture simulations and hazard planning. Thus, compiling a micro-earthquake catalogue for the Southern Alps prior to an expected major earthquake is of great interest. Areas of low seismic activity, like the central part of the Alpine Fault, require data recorded over a long duration to reveal temporal and spatial seismicity patterns and provide a better understanding for the processes controlling seismogenesis. The continuity and density of the Southern Alps Microearthquake Borehole Array (SAMBA; deployed in late 2008) allows us to study seismicity in the Southern Alps over a more extended time period than has ever been done previously. Furthermore, by using data from other temporary networks (e.g. WIZARD, ALFA08, DFDP-10) we are able to extend the region covered. To generate a spatially and temporally continuous catalogue of seismicity in New Zealand's central Southern Alps, we used automatic detection and phase-picking methods. We used an automatic phase-picking method for both P- and S- wave arrivals (kPick; Rawles and Thurber, 2015). Using almost 8 years of seismic data we calculated about 9,000 preliminary earthquake. The seismicity is clustered and scattered and a previously observed seismic gap between the Wanganui and Whataroa rivers is also identified.

  20. On-demand Simulation of Atmospheric Transport Processes on the AlpEnDAC Cloud

    Science.gov (United States)

    Hachinger, S.; Harsch, C.; Meyer-Arnek, J.; Frank, A.; Heller, H.; Giemsa, E.

    2016-12-01

    The "Alpine Environmental Data Analysis Centre" (AlpEnDAC) develops a data-analysis platform for high-altitude research facilities within the "Virtual Alpine Observatory" project (VAO). This platform, with its web portal, will support use cases going much beyond data management: On user request, the data are augmented with "on-demand" simulation results, such as air-parcel trajectories for tracing down the source of pollutants when they appear in high concentration. The respective back-end mechanism uses the Compute Cloud of the Leibniz Supercomputing Centre (LRZ) to transparently calculate results requested by the user, as far as they have not yet been stored in AlpEnDAC. The queuing-system operation model common in supercomputing is replaced by a model in which Virtual Machines (VMs) on the cloud are automatically created/destroyed, providing the necessary computing power immediately on demand. From a security point of view, this allows to perform simulations in a sandbox defined by the VM configuration, without direct access to a computing cluster. Within few minutes, the user receives conveniently visualized results. The AlpEnDAC infrastructure is distributed among two participating institutes [front-end at German Aerospace Centre (DLR), simulation back-end at LRZ], requiring an efficient mechanism for synchronization of measured and augmented data. We discuss our iRODS-based solution for these data-management tasks as well as the general AlpEnDAC framework. Our cloud-based offerings aim at making scientific computing for our users much more convenient and flexible than it has been, and to allow scientists without a broad background in scientific computing to benefit from complex numerical simulations.

  1. Terricolous Lichens in the Glacier Forefield of the Pasterze (Eastern Alps, Carinthia, Austria)

    Science.gov (United States)

    Bilovitz, Peter O.; Wallner, Anja; Tutzer, Veronika; Nascimbene, Juri; Mayrhofer, Helmut

    2016-01-01

    Summary The investigation of lichens on soil, plant debris and terricolous mosses in the glacier forefield of the Pasterze yielded 35 lichen species. Placidiopsis oreades Breuss (Verrucariales) is new to Austria. Three sampling sites were established at increasing distance from the glacier, in order to compare species diversity, abundance and composition within the forefield and with four other glacier forefields of the Eastern Alps. PMID:26877565

  2. Climate - Change - Alps. Tourism and regional planning in weather load. Proceedings; Klima - Wandel - Alpen. Tourismus und Raumplanung im Wetterstress. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    Within the international annual conference ''Climate-Change-Alps Tourism and regional planning under weather load'' between 18th and 20th May, 2006, in Bad Hindelang (federal Republic of Germany) lectures were held to the following topics: (a) CIPRA resolution; (b) Future in the Alps - Distribution of knowledge, networking of people; (c) Climatic change and climate protection; (d) Planning of nature dangers; (e) Tourism.

  3. Spatial and temporal variations of glacial erosion in the Rhône valley (Swiss Alps): Insights from numerical modeling

    OpenAIRE

    Sternai , Pietro; Herman , Frédéric; Valla , Pierre G.; Champagnac , Jean-Daniel

    2013-01-01

    Pietro Sternai : Now at: the Institut desSciences de laTerre d'Orléans - (ISTO), University of Orléans,France. Tel.: 33 631910242. E-mail addresses: , ; International audience; The present-day topography of the European Alps shows evidence of intense glacial reshaping. However, significant questions regarding Alpine landscape evolution during glaciations still persist. In this study, we focus on the Rhône valley (Swiss Alps), and use a ...

  4. Gravity anomalies, seismic structure and geothermal history of the Central Alps

    International Nuclear Information System (INIS)

    Kissling, E.; Mueller, S.; Werner, D.

    1983-01-01

    A new interpretation of the gravity anomalies in the Swiss Alps from the geothermal point of view is presented. The regional gravity distribution is partly caused by the topography of the crust-mantle boundary. Taking 0.5 g/cm 3 as the average density contrast between crust and mantle the Bouguer map of Switzerland contains a residual field which indicates a density anomaly in the mantle. This finding, results from seismic surface-wave investigations, and P-wave travel time observations can be interpreted as a consequence of the genesis of the Alps. A kinematic model of the Alps has been constructed simulating the mass displacements during the last 40 m.y. In this two-dimensional model the subsidence of cold mantle material is taken into consideration forming a ''lithospheric root''. Based on this kinematic model the temperature distribution in the moving medium can be calculated, taking into account the radiogenic heat sources. From the calculated temperatures field at present time the thermally induced density deviation can be determined. This density effect can explain the residual gravity field with a maximum value of about + 50 mgal

  5. Climate change in the Alps: impacts and natural risks. ONERC's Technical Report N.1

    International Nuclear Information System (INIS)

    2008-01-01

    Mountain ranges are very sensitive to climatic variations. The impacts of climate change on theses territories can be various, from the modification of the biodiversity to the permafrost melting and the evolution of natural hazards. The assessment of temperature rise and its impacts on mountains constitutes an important issue considering the strong uncertainties and the specific sensitivity linked to these areas. The territorial manager - policy makers and technicians - have to deal with this questioning for the implementation of short term actions as well as for strategic choices in terms of land planning and spatial development. This is why 22 public institutions from seven Alpine countries were involved in the European ClimChAlp project. The ONERC participated actively to this project in collaboration with the Rhone-Alpes Region and the Pole Grenoblois Risques Naturels. This report is based on the synthesis realised by the French partners to propose a common base of knowledge about climate change and its impacts in the Alps. (authors)

  6. The ALPS project release 2.0: open source software for strongly correlated systems

    International Nuclear Information System (INIS)

    Bauer, B; Gamper, L; Gukelberger, J; Hehn, A; Isakov, S V; Ma, P N; Mates, P; Carr, L D; Evertz, H G; Feiguin, A; Freire, J; Koop, D; Fuchs, S; Gull, E; Guertler, S; Igarashi, R; Matsuo, H; Parcollet, O; Pawłowski, G; Picon, J D

    2011-01-01

    We present release 2.0 of the ALPS (Algorithms and Libraries for Physics Simulations) project, an open source software project to develop libraries and application programs for the simulation of strongly correlated quantum lattice models such as quantum magnets, lattice bosons, and strongly correlated fermion systems. The code development is centered on common XML and HDF5 data formats, libraries to simplify and speed up code development, common evaluation and plotting tools, and simulation programs. The programs enable non-experts to start carrying out serial or parallel numerical simulations by providing basic implementations of the important algorithms for quantum lattice models: classical and quantum Monte Carlo (QMC) using non-local updates, extended ensemble simulations, exact and full diagonalization (ED), the density matrix renormalization group (DMRG) both in a static version and a dynamic time-evolving block decimation (TEBD) code, and quantum Monte Carlo solvers for dynamical mean field theory (DMFT). The ALPS libraries provide a powerful framework for programmers to develop their own applications, which, for instance, greatly simplify the steps of porting a serial code onto a parallel, distributed memory machine. Major changes in release 2.0 include the use of HDF5 for binary data, evaluation tools in Python, support for the Windows operating system, the use of CMake as build system and binary installation packages for Mac OS X and Windows, and integration with the VisTrails workflow provenance tool. The software is available from our web server at http://alps.comp-phys.org/

  7. The Occurrence of Cold Spells in the Alps Related to ClimateChange

    Directory of Open Access Journals (Sweden)

    Seon Ki Park

    2010-08-01

    Full Text Available Climate change is not only a likely prospect for the end of this century, but it is already occurring. Part of the changes will include global warming and increasing temperature variability, both at global and regional scales. This increased variability was investigated in this paper from the point of view of the occurrence of cold spells in the Alps in the future climate (2071–2100, compared with the present climate (1961–1990. For this purpose, a regionalisation of the climate change effects was performed within the Alps. To avoid possible errors in the estimate of the 2m air temperature, the analysis was performed on the soil surface temperature. To get realistic values for this variable, a land surface scheme, UTOPIA, has been run on the selected domain, using the output of the Regional Climate Model (RegCM3 simulations as the driving force. The results show that, in general, the number of cold breaks is decreasing over the Alps, due to the temperature increment. However, there are certain zones where the behaviour is more complicated. The analysis of the model output also allowed a relationship to be found between the number of cold breaks and their duration. The significance of these results over the whole area was assessed.

  8. Towards an Excursion Flora for Austria and all the Eastern Alps

    Directory of Open Access Journals (Sweden)

    Manfred A. Fischer

    2018-02-01

    Full Text Available This is on the one hand an announcement of the two-volume Fourth Edition of the Excursion Flora for Austria expanded by also including the remaining parts of the Eastern Alps (chapter 1, and on the other hand a rough survey of the flora of the Eastern Alps in connection with the main vegetation types (chapter 2. The geographical scope includes, besides Austria, the entire Eastern Alps from the Rhine valley in E Switzerland (Grisons to the Vipava valley in SW Slovenia. Volume 1 mainly contains comprehensive introductory chapters like introductions to plant morphology, taxonomy, and nomenclature, as well as a sketch of ecomorphology and habitat ecology, a survey of vegetation types (phytosociology and floristic peculiarities of the different natural regions, a rough history of floristic research, a detailed glossary including the meaning of epithets, etc., and drawings of several plant species characteristic of the flora covered. The structure of the keys concentrated in volume 2 is explained: besides the descriptive traits, they include for each taxon comprehensive ecological and plant geographical data, as well as information about Red Lists of the countries involved, plant uses, and taxonomical problems. Genus names are given not only in German, but also in the Romansh (Rumantsch Grischun, Italian, and Slovenian languages. In chapter 2, some important chorotypes including endemics are characterised, and an overview of floristic diversity (lists of exemplary taxa in accordance with the main and most characteristic vegetation types is presented.

  9. Origin of polluted air masses in the Alps. An overview and first results for MONARPOP

    International Nuclear Information System (INIS)

    Kaiser, August

    2009-01-01

    The contribution of ZAMG to MONAROP consists of special weather forecasts to control the SOCs sampling procedure and of the analysis of the specific transport processes for SOCs, which is still in progress. In this paper, air pollutant transport into the Alps is demonstrated by examples of inorganic pollutants: Measurements of NO x and ozone provide evidence for air pollutant transport by local wind systems (valley and slope winds), especially at low elevated sites of the Alps. In addition, trajectory analyses for the high elevation sites demonstrate the importance of large scale synoptic air pollutant transport. The effects of these transport processes with different spatial and temporal scales are governed by the physical and chemical properties of the particular pollutant. First results for the high alpine MONARPOP stations show that air masses from east Europe influence mostly Sonnblick (Austria), whereas the influence of the Po basin is strongest at Weissfluhjoch (Switzerland). - Effects of meteorological transport processes on air pollution in the Alps are demonstrated by examples of inorganic pollutants and first conclusions for SOCs are drawn.

  10. Marfan Syndrome

    Science.gov (United States)

    Marfan syndrome is a disorder that affects connective tissue. Connective tissues are proteins that support skin, bones, blood vessels, ... A problem with the fibrillin gene causes Marfan syndrome. Marfan syndrome can be mild to severe, and ...

  11. Aarskog syndrome

    Science.gov (United States)

    Aarskog disease; Aarskog-Scott syndrome; AAS; Faciodigitogenital syndrome; Gaciogenital dysplasia ... Aarskog syndrome is a genetic disorder that is linked to the X chromosome. It affects mainly males, but females ...

  12. Williams syndrome

    Science.gov (United States)

    Williams-Beuren syndrome ... Williams syndrome is caused by not having a copy of several genes. It may be passed down in families. ... history of the condition. However, people with Williams syndrome have a 50% chance of passing the disorder ...

  13. Cushing's Syndrome

    OpenAIRE

    宗, 友厚; 伊藤, 勇; 諏訪, 哲也; 武田, 純; MUNE, Tomoatsu

    2003-01-01

    Sixteen cases of verified Cushing's syndrome, and twelve cases of probable Cushing's syndrome were reviewed and data on them were compared with various reports on Cushing's syndrome in the literature.

  14. Tourette syndrome

    Science.gov (United States)

    Gilles de la Tourette syndrome; Tic disorders - Tourette syndrome ... Tourette syndrome is named for Georges Gilles de la Tourette, who first described this disorder in 1885. The disorder is likely passed down through families. ...

  15. Statistical downscaling of regional climate scenarios for the French Alps : Impacts on snow cover

    Science.gov (United States)

    Rousselot, M.; Durand, Y.; Giraud, G.; Mérindol, L.; Déqué, M.; Sanchez, E.; Pagé, C.; Hasan, A.

    2010-12-01

    Mountain areas are particularly vulnerable to climate change. Owing to the complexity of mountain terrain, climate research at scales relevant for impacts studies and decisive for stakeholders is challenging. A possible way to bridge the gap between these fine scales and those of the general circulation models (GCMs) consists of combining high-resolution simulations of Regional Climate Models (RCMs) to statistical downscaling methods. The present work is based on such an approach. It aims at investigating the impacts of climate change on snow cover in the French Alps for the periods 2021-2050 and 2071-2100 under several IPCC hypotheses. An analogue method based on high resolution atmospheric fields from various RCMs and climate reanalyses is used to simulate local climate scenarios. These scenarios, which provide meteorological parameters relevant for snowpack evolution, subsequently feed the CROCUS snow model. In these simulations, various sources of uncertainties are thus considered (several greenhouse gases emission scenarios and RCMs). Results are obtained for different regions of the French Alps at various altitudes. For all scenarios, temperature increase is relatively uniform over the Alps. This regional warming is larger than that generally modeled at the global scale (IPCC, 2007), and particularly strong in summer. Annual precipitation amounts seem to decrease, mainly as a result of decreasing precipitation trends in summer and fall. As a result of these climatic evolutions, there is a general decrease of the mean winter snow depth and seasonal snow duration for all massifs. Winter snow depths are particularly reduced in the Northern Alps. However, the impact on seasonal snow duration is more significant in the Southern and Extreme Southern Alps, since these regions are already characterized by small winter snow depths at low elevations. Reference : IPCC (2007a). Climate change 2007 : The physical science basis. Contribution of working group I to the

  16. Structurally controlled 'teleconnection' of large-scale mass wasting (Eastern Alps)

    Science.gov (United States)

    Ostermann, Marc; Sanders, Diethard

    2015-04-01

    In the Brenner Pass area (Eastern Alps) , closely ahead of the most northward outlier ('nose') of the Southern-Alpine continental indenter, abundant deep-seated gravitational slope deformations and a cluster of five post-glacial rockslides are present. The indenter of roughly triangular shape formed during Neogene collision of the Southern-Alpine basement with the Eastern-Alpine nappe stack. Compression by the indenter activated a N-S striking, roughly W-E extensional fault northward of the nose of the indenter (Brenner-normal fault; BNF), and lengthened the Eastern-Alpine edifice along a set of major strike-slip faults. These fault zones display high seismicity, and are the preferred locus of catastrophic rapid slope failures (rockslides, rock avalanches) and deep-seated gravitational slope deformations. The seismotectonic stress field, earthquake activity, and structural data all indicate that the South-Alpine indenter still - or again - exerts compression; in consequence, the northward adjacent Eastern Alps are subject mainly to extension and strike-slip. For the rockslides in the Brenner Pass area, and for the deep-seated gravitational slope deformations, the fault zones combined with high seismic activity predispose massive slope failures. Structural data and earthquakes mainly record ~W-E extension within an Eastern Alpine basement block (Oetztal-Stubai basement complex) in the hangingwall of the BNF. In the Northern Calcareous Alps NW of the Oetztal-Stubai basement complex, dextral faults provide defacement scars for large rockfalls and rockslides. Towards the West, these dextral faults merge into a NNW-SSE striking sinistral fault zone that, in turn, displays high seismic activity and is the locus of another rockslide cluster (Fern Pass cluster; Prager et al., 2008). By its kinematics dictated by the South-Alpine indenter, the relatively rigid Oetztal-Stubai basement block relays faulting and associated mass-wasting over a N-S distance of more than 60

  17. Hepatorenal syndrome

    Science.gov (United States)

    ... 2016:chap 153. Nevah MI, Fallon MB. Hepatic encephalopathy, hepatorenal syndrome, hepatopulmonary syndrome, and other systemic complications of liver disease. In: Feldman M, Friedman LS, Brandt LJ, ...

  18. Enercoop Rhone-Alpes: a green and citizen-oriented electricity; Enercoop Rhone-Alpes l'electricite verte et citoyenne

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Enercoop is a collective interest cooperative company which aims at providing electricity from renewable sources and at developing renewable energies in France. After a presentation of its objectives and strategies, this document gives an overview of the energy and socio-economic context in Europe and France, recalls the origin of this project and more particularly in the Rhone-Alpes region. It presents its objectives in terms of pricing and citizen empowerment, how to join Enercoop, its guarantees, its philosophy (ethical and democratic), its objectives in terms of renewable energy production, its relationship with ERDF (the company which manages the electricity distribution network in France). After some testimonies, some comments are made about energy management challenges

  19. Low-grade metamorphism in the eastern Southern Alps: Distribution, conditions, timing and implications for the tectonics of the Alps and NW Dinarides

    Science.gov (United States)

    Neubauer, Franz; Heberer, Bianca; Genser, Johann; Friedl, Getrude

    2014-05-01

    Based on 40Ar/39Ar dating of newly-grown syntectonic metamorphic white mica (sericite), we recognize for the first time the timing of Alpine low-grade metamorphism in the eastern part of the Southalpine unit: (1) A Silurian phyllite of Seeberg inlier located to the south of the Periadriatic fault yields a plateau age at c. 75 Ma suggesting a Late Cretaceous age of previously recognized low-grade (Rantitsch & Rainer, 2003) metamorphism. (2) Within the Tolmin nappe, four sericite plateau ages of mainly Middle Triassic volcanics are at c. 51 Ma (Early Eocene). The Late Cretaceous age in the Seeberg inlier is considered to record ductile deformation during formation of a retro-wedge related to the Eo-Alpine orogeny in the Austroalpine units in the Eastern Alps exposed north of the future Periadriatic fault. The Eocene age at the boundary of very low-grade to low-grade metamorphism in the Tolmin nappe (Rainer et al., 2009) relates to the emplacement of the Southalpine nappe complex onto the Dinarides and is contemporaneous with the initial ductile deformation in the Dinarides during Adria-directed shortening and formation of a siliciclastic flysch belt in front of the SW-directed growing fold-thrust belt (Placer, 2008). Similar rare Late Cretaceous and dominant Eocene ages within post-Variscan units are virtually more widespread in the Southalpine unit and Dinarides as considered before. These regions include the Collio basin (Feijth, 2002) and the Eder unit (Läufer et al., 1996) in the western and central Southern Alps, in the internal NW Dinarides (Borojević Šoštarić et al., 2012) and the Mid Bosnian Schist Mountains (Pamić et al., 2004) and Lim Paleozoic unit in the central Dinarides (Ilic et al., submitted). Consequently, the Southalpine unit and Dinarides were affected by two stages of metamorphism, Late Cretaceous (ca. 80 to 75 Ma) and Eocene (ca. 51 - 40 Ma), both stages are related to back-thrusting. The ages of metamorphism are different from those in the

  20. Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease

    OpenAIRE

    Vickers, Mark A; Wilkie, Gwen M; Robinson, Nicolas; Rivera, Nadja; Haque, Tanzina; Crawford, Dorothy H; Barry, Jacqueline; Fraser, Neil; Turner, David M; Robertson, Victoria; Dyer, Phil; Flanagan, Peter; Newlands, Helen R; Campbell, John; Turner, Marc L

    2014-01-01

    Epstein-Barr virus (EBV) is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Conventional treatments for PTLD are often successful, but risk organ rejection and cause significant side effects. EBV-specific cytotoxic T lymphocytes (CTLs) generated in vitro from peripheral blood lymphocytes provide an alternative treatment modality with few side effects, but autologous CTLs are difficult to use in clinical practice. Here we report the establis...

  1. Ephemeroptera, Plecoptera and Trichoptera in springs in Trentino (south-eastern Alps

    Directory of Open Access Journals (Sweden)

    Luana SILVERI

    2011-09-01

    Full Text Available Within the CRENODAT project (Biodiversity assessment and integrity evaluation of springs of Trentino - Italian Alps - and longterm ecological research, 2004-2008 we studied a total of 90 springs in Trentino (south-eastern Alps, Italy, 75 of which were used for statistical analysis. The springs were grouped into seven different types and represented all the available lithologies in the study area. Macrozoobenthos (Ephemeroptera, Plecoptera and Trichoptera; EPT was collected from stones, bryophytes and sediments. We investigated which physical, chemical or environmental features were important in determining EPT assemblage metrics at sites, by calculating the Shannon-Wiener diversity index, and applying a one-way ANOVA test, ANOSIM and SIMPER analyses. Statistical results highlighted the island character of the springs, each spring having its specific history and abiotic characteristics, which select for unique community patterns. For the faunistic analyses, we considered all springs where EPT taxa were recorded; a total of 88 taxa. Highest species richness was recorded among the Trichoptera, followed by the Plecoptera and Ephemeroptera, with 52, 30 and 6 taxa respectively. Fifteen Trichoptera and three Plecoptera species were recorded as new for the Autonomous Province of Trento. Our results confirm that, in the harsh environment of the Alps, the mild and stable ecological conditions that characterize spring-fed brooks contribute to maintaining and enhancing the regional biodiversity. Springs act as refuge areas for stream biota, providing more favourable conditions during spates or droughts (common in Alpine headwaters, or for particular stages of the insect life cycles. Springs also provide specific habitats for strictly crenobiontic species.

  2. End of the Little Ice Age in the Alps forced by industrial black carbon.

    Science.gov (United States)

    Painter, Thomas H; Flanner, Mark G; Kaser, Georg; Marzeion, Ben; VanCuren, Richard A; Abdalati, Waleed

    2013-09-17

    Glaciers in the European Alps began to retreat abruptly from their mid-19th century maximum, marking what appeared to be the end of the Little Ice Age. Alpine temperature and precipitation records suggest that glaciers should instead have continued to grow until circa 1910. Radiative forcing by increasing deposition of industrial black carbon to snow may represent the driver of the abrupt glacier retreats in the Alps that began in the mid-19th century. Ice cores indicate that black carbon concentrations increased abruptly in the mid-19th century and largely continued to increase into the 20th century, consistent with known increases in black carbon emissions from the industrialization of Western Europe. Inferred annual surface radiative forcings increased stepwise to 13-17 W⋅m(-2) between 1850 and 1880, and to 9-22 W⋅m(-2) in the early 1900s, with snowmelt season (April/May/June) forcings reaching greater than 35 W⋅m(-2) by the early 1900s. These snowmelt season radiative forcings would have resulted in additional annual snow melting of as much as 0.9 m water equivalent across the melt season. Simulations of glacier mass balances with radiative forcing-equivalent changes in atmospheric temperatures result in conservative estimates of accumulating negative mass balances of magnitude -15 m water equivalent by 1900 and -30 m water equivalent by 1930, magnitudes and timing consistent with the observed retreat. These results suggest a possible physical explanation for the abrupt retreat of glaciers in the Alps in the mid-19th century that is consistent with existing temperature and precipitation records and reconstructions.

  3. Relationship between rainfall and shallow landslides in the southern Apuan Alps (Italy

    Directory of Open Access Journals (Sweden)

    R. Giannecchini

    2006-01-01

    Full Text Available The Apuan Alps region is one of the rainiest areas in Italy (more than 3000 mm/year, in which frequently heavy and concentrated rainfall occurs. This is particularly due to its geographical position and conformation: the Apuan chain is located along the northern Tuscan coast, close to the Ligurian Sea, and the main peaks reach almost 2000 m. In several cases, the storms that hit the area have triggered many shallow landslides (soil slip-debris flows, which exposed the population to serious risks (during the 19 June 1996 rainstorm about 1000 landslides were triggered and 14 people died. The assessment of the rainfall thresholds is very important in order to prepare efficient alarm systems in a region particularly dedicated to tourism and marble activities. With the aim of contributing to the landslide hazard evaluation of the southern Apuan Alps territory (upper Versilia area, a detailed analysis of the main pluviometric events was carried out. The data recorded at the main rain gauge of the area from 1975 to 2002 were analysed and compared with the occurrence of soil slips, in order to examine the relationship between soil slip initiation and rainfall. The most important rainstorms which triggered shallow landslides occurred in 1984, 1992, 1994, 1996, 1998 and 2000. Many attempts were made to obtain a possible correlation between rainfall parameters and the occurrence of soil slip phenomena and to identify the local rainfall threshold for triggering shallow landslides. A threshold for soil slip activity in terms of mean intensity, duration and mean annual precipitation (MAP was defined for the study area. The thresholds obtained for the southern Apuan Alps were also compared with those proposed by other authors for several regions in the world. This emphasized the high value of the rain threshold for shallow landslide activity in the Apuan area. The high threshold is probably also linked to the high mean annual precipitation and to the high

  4. Recent slope failures in the Dolomites (Northeastern Italian Alps) in a context of climate change

    Science.gov (United States)

    Chiarle, Marta; Paranunzio, Roberta; Laio, Francesco; Nigrelli, Guido; Guzzetti, Fausto

    2014-05-01

    Climate change in the Greater Alpine Region is seriously affecting permafrost distribution, with relevant consequences on slope stability. In the Italian Alps, the number of failures from rockwalls at high elevation markedly increased in the last 20-30 years: the consistent temperature increase, which warmed twice than the global average, may have seriously influenced slope stability, in terms of glaciers retreat and permafrost degradation. Moreover, the growing number of tourists and activities in alpine regions (in particular in the Dolomites) made these areas particularly critical in relation to natural hazards. In this light, an integrated short-term geomorphological and climatic analysis was performed, in order to better comprehend the impact of main climate elements (especially temperature and precipitation) on slope failures in high mountain areas. In this contribution, we focus on three recent slope failures occurred at high elevation sites in the Dolomites (Northeastern Italian Alps), declared a UNESCO World Heritage Site in August 2009. We describe here three important rock falls occurred in the autumn 2013: 1) the Sorapiss rock fall, on 30 September 2013; 2) the Monte Civetta rock fall, on 16 November 2013; 3) the Monte Antelao rock fall, on 22 November 2013. The Monte Civetta rock fall damaged some climbing routes, while the other two landslides did not cause any damage or injury. Despite the limited volume involved, these three events represent an important warning sign in the context of ongoing climate change. Geomorphological information about the rock fall sites were combined with the climatic data acquired from the meteorological stations surrounding the slope failure areas. A short-term climatic analysis was performed, with the aim of understanding the role of the main climatic elements in the triggering of natural instability events in this area and in the Alps in general.

  5. Meteorological conditions of the mudflow origin in the northern part of the French Alps

    Directory of Open Access Journals (Sweden)

    L. O. Pavlova

    2012-01-01

    Full Text Available A mudflow phenomena are at the top of the list of dangerous natural hazards in the mountains areas all over the world. Among factors resulting in a mudflow phenomena triggering, meteorological conditions are considered to be the most relevant. The general objective of this study was to identify meteorological parameters controlling the triggering of mudflow phenomena in one part of the French Alps over the last 40 years. Major factors are quite well explored at the global scale or contrariwise in very precise territory in particular catchment areas. However, for now we have a poor knowledge of those factors at the scale of a medium-sized region (including catchments with different geomorphic characteristics over several km² especially in the French Alps. In addition, in this region only a few studies focused on relationships with climate. To understand mudflow phenomena activity and their link with meteorological parameters in the north region of the French Alps, we used a multivariate statistical approach. Regional meteorological parameters (such as mean monthly temperature and precipitation were first computed from a Principal Component Analysis of observed meteorological data from four weather stations. A binomial monthly logistic regression probability model was then fitted between the main principal components and mudflow phenomena data base composed of 298 debris flow events triggered between 1971 and 2008. Results revealed that the most successful model including two meteorological predictors (minimal monthly temperature and the number of rainy days between May and September correctly explains more than 60% of the mudflow phenomena events.

  6. Monochroa bronzella sp. n. from the southwestern Alps (Lepidoptera: Gelechiidae)

    DEFF Research Database (Denmark)

    Karsholt, Ole; Nel, Jacques; Fournier, François

    2013-01-01

    Abstract. Monochroa bronzella sp. n. is described from the southwestern Alps (France, Italy). It is closely related to M. nomadella (Zeller, 1868), with which it was hitherto confused. Literature records of M. nomadella from France and northwestern Italy refer to M. bronzella sp. n. The two species...... are most clearly distinguishable in the signa of the female genitalia. Females of both species have reduced wings, most pronounced in M. nomadella. The new species is found in mountain areas at altitudes from around 800 to 2000 m. Adults and male and female genitalia of these two species are figured....

  7. Seasonal evaluation of serumal Ca, P and ALP of slaughtered cattle in Tabriz abattoir

    Directory of Open Access Journals (Sweden)

    A.P Rezaei-Saber

    2008-08-01

    Full Text Available Increasing knowledge of metabolic disorders and prevention of any prduction decrease is beneficial in animal breeding. Problems related to calcium and phosphorus deficiency in high producing animals are among the most important metabolic disorders with disease such as osteomalacia, rickets, milk fever, pos parturition hemoglobinuria and reproductive disorders named as the metabolic complications. This study was conducted on non pregnant crossbreed dairy cattle. In the middle of each season with daily referral to the abattoir, blood samples were collected in veneject tubes and after transfer to the laboratory, the serumic levels of Ca, P and ALP were measured by spectrophotometry. One hundred samples for each season and a total of 400 samples were studied. The mean serumic levels of Ca, P and ALP were 8.83±0.02 mg/dl, 3.88±0.07 mg/dl, 163.4±0.8 Iu/lit; 9.05±0.03mg/dl, 4.19±0.01mg/dl, 240.7±1.2 Iu/lit; 9.03±0.07 mg/dl, 5.33±0.02mg/dl, 185.06±2.3 Iu/lit and 9.33±0.09 mg/dl, 5.74±0.08 mg/dl, 230.03±7.4 Iu/lit, in the spring, summer, autumn and winter respectively. Considering the normal Ca, P and ALP values in cattle, 6.3% and 83% of cases had Ca and P deficiency respectively in the spring, 80% of cases had subclinical phosphorus deficiency in the summer, 7.3% of cases had subclinical phosphorus deficiency in the autumn and 9.45% and 7.36% of cases had Ca deficiency and ALP elevation respectively in the winter. The significant decrease in Ca and P levels in the spring and P levels in the summer (p

  8. Lithospheric architecture of the South-Western Alps revealed by multiparameter teleseismic full-waveform inversion

    Science.gov (United States)

    Beller, S.; Monteiller, V.; Operto, S.; Nolet, G.; Paul, A.; Zhao, L.

    2018-02-01

    The Western Alps, although being intensively investigated, remains elusive when it comes to determining its lithospheric structure. New inferences on the latter are important for the understanding of processes and mechanisms of orogeny needed to unravel the dynamic evolution of the Alps. This situation led to the deployment of the CIFALPS temporary experiment, conducted to address the lack of seismological data amenable to high-resolution seismic imaging of the crust and the upper mantle. We perform a 3-D isotropic full-waveform inversion (FWI) of nine teleseismic events recorded by the CIFALPS experiment to infer 3-D models of both density and P- and S-wave velocities of the Alpine lithosphere. Here, by FWI is meant the inversion of the full seismograms including phase and amplitude effects within a time window following the first arrival up to a frequency of 0.2 Hz. We show that the application of the FWI at the lithospheric scale is able to generate images of the lithosphere with unprecedented resolution and can furnish a reliable density model of the upper lithosphere. In the shallowest part of the crust, we retrieve the shape of the fast/dense Ivrea body anomaly and detect the low velocities of the Po and SE France sedimentary basins. The geometry of the Ivrea body as revealed by our density model is consistent with the Bouguer anomaly. A sharp Moho transition is followed from the external part (30 km depth) to the internal part of the Alps (70-80 km depth), giving clear evidence of a continental subduction event during the formation of the Alpine Belt. A low-velocity zone in the lower lithosphere of the S-wave velocity model supports the hypothesis of a slab detachment in the western part of the Alps that is followed by asthenospheric upwelling. The application of FWI to teleseismic data helps to fill the gap of resolution between traditional imaging techniques, and enables integrated interpretations of both upper and lower lithospheric structures.

  9. Possible impacts of forest decline on the protection functions of forests in the Bavarian Alps

    Energy Technology Data Exchange (ETDEWEB)

    Suda, M

    1989-01-01

    In context with the forest decline phenomenon the question arises on how the protection function of forests will be affected and how possible impacts can be evaluated. First, a solution model based on a feedback-circle system is presented, which allows to assess possible impacts of forest decline on massmovements. The application of this approach to the avalanche and flooding phenomena is presented and demonstrated by model calculations for different examples in the country of Traunstein/Bavaria Alps. Finally, a model is presented which gives an answer to the question, what impacts on the tourism industry are possible due to forest decline and how these influences can be evaluated.

  10. Stars in the Silurian sky: Echinoderm holdfasts from the Carnic Alps, Austria

    International Nuclear Information System (INIS)

    Ferretti, A.; Ausich, W.I.; Corradini, C.; Corriga, M.G.; Schoenlaub, H.P.

    2016-01-01

    A small collection of echinoderm holdfasts from the Ludlow Cardiola Formation of the Carnic Alps (Austria) contains a wide range of morphologies as a response of environmental adaptation. In general, the holdfasts have a globous and massive dome-like profile with several processes arranged in a sub-radial disposition, so to create a sort of ‘star-like’ outline. A small central depression is common but not present on all specimens. The distinctive holdfasts are preserved in an iron-rich phase, documenting a substitution that has also affected other non-echinoderm calcareous material. (Author)

  11. methanization development and air quality. Bibliographical synthesis and working perspectives in Rhone-Alpes 2016

    International Nuclear Information System (INIS)

    2016-06-01

    After a recall of a context which promotes the development of the methanization sector, and in order to address social acceptance issues related to methanization installations, this report aims at proposing a synthesis of existing documents related to methanization and its possible interactions with air quality. A first part briefly describes a methanization unit. The second part proposes an overview of the situation of projects in the Rhone-Alpes region. The third part proposes an overview of knowledge regarding potential impacts on air quality and greenhouse gas emissions

  12. Ecology of some mire and bog plant communities in the Western Italian Alps

    Directory of Open Access Journals (Sweden)

    Giorgio BUFFA

    2003-02-01

    Full Text Available During a mire vegetation study, conducted mainly in the subalpine-alpine sector of the Western Italian Alps, the ecology of several plant communities and numerous moss species of this kind of vegetation was evaluated. The study area covered the Piedmontese sector of the Graian Alps, the eastern sector of the Aosta Valley as well as certain localities of the Pennine Alps, the Canavese district and the Maritime Alps. They have a rocky substratum representative of the various regional lithologies and include the main sectors characterised by the highest precipitation. Three hundred and twenty two relevées were made using the phytosociological method and the pH and the conductivity of the water table and its depth were measured directly. Cluster Analysis allowed a classification of the samples and the identification of various groups of plant communities. Ordination performed by DCA and CCA allowed us to identify the ecological features of the various plant communities by using the values of the main environmental parameters, measured directly in the field, and certain climatic parameters (altitude and mean annual precipitation available. The use of climatic parameters is an important result for identifying communities which show greater oceanicity, something that is underlined also by the presence of indicator species such as Sphagnum papillosum and S. subnitens. Furthermore the communities are arranged in a "poor-rich" gradient, and are also profoundly influenced by depth to water table which is inversely correlated to the pH. Therefore we find certain kinds of communities all with a very low water table and which are little affected by its chemistry. Other groups share the fact that the water table is outcropping or near the surface and are distinguishable for their pH values and conductivity. We discuss the different response of the bryophytes and vascular plants of these communities to the environmental parameters considered, in light of their

  13. Hemin binding by Porphyromonas gingivalis strains is dependent on the presence of A-LPS.

    Science.gov (United States)

    Rangarajan, M; Aduse-Opoku, J; Paramonov, N A; Hashim, A; Curtis, M A

    2017-10-01

    Porphyromonas gingivalis is a Gram-negative black pigmenting anaerobe that is unable to synthesize heme [Fe(II)-protoporphyrin IX] or hemin [Fe(III)-protoporphyrin IX-Cl], which are important growth/virulence factors, and must therefore derive them from the host. Porphyromonas gingivalis expresses several proteinaceous hemin-binding sites, which are important in the binding/transport of heme/hemin from the host. It also synthesizes several virulence factors, namely cysteine-proteases Arg- and Lys-gingipains and two lipopolysaccharides (LPS), O-LPS and A-LPS. The gingipains are required for the production of the black pigment, μ-oxo-bisheme {[Fe(III)PPIX] 2 O}, which is derived from hemoglobin and deposited on the bacterial cell-surface leading to the characteristic black colonies when grown on blood agar. In this study we investigated the role of LPS in the deposition of μ-oxo-bisheme on the cell-surface. A P. gingivalis mutant defective in the biosynthesis of Arg-gingipains, namely rgpA/rgpB, produces brown colonies on blood agar and mutants defective in Lys-gingipain (kgp) and LPS biosynthesis namely porR, waaL, wzy, and pg0129 (α-1, 3-mannosyltransferase) produce non-pigmented colonies. However, only those mutants lacking A-LPS showed reduced hemin-binding when cells in suspension were incubated with hemin. Using native, de-O-phosphorylated and de-lipidated LPS from P. gingivalis W50 and porR strains, we demonstrated that hemin-binding to O-polysaccharide (PS) and to the lipid A moiety of LPS was reduced compared with hemin-binding to A-PS. We conclude that A-LPS in the outer-membrane of P. gingivalis serves as a scaffold/anchor for the retention of μ-oxo-bisheme on the cell surface and pigmentation is dependent on the presence of A-LPS. © 2017 The Authors. Molecular Oral Microbiology Published by John Wiley & Sons Ltd.

  14. Possible environmental effects on the evolution of the Alps-Molasse basin system

    International Nuclear Information System (INIS)

    Schlunegger, F.; Rieke-Zapp, D.; Ramseyer, K.

    2007-01-01

    We propose three partly unrelated stages in the geodynamic evolution of the Alps and the sedimentary response of the Molasse Basin. The first stage comprises the time interval between ca. 35 and 20 Ma and is characterized by a high ratio between rates of crustal accretion and surface erosion. The response of the Molasse Basin was a change from the stage of basin underfill (UMM) to overfill (USM). Because the response time of erosional processes to crustal accretion and surface uplift lasts several millions of years, the orogen first experienced a net growth until the end of the Oligocene. As a result, the Molasse basin subsided at high rates causing the topographic axis to shift to the proximal basin border and alluvial fans to establish at the thrust front. During the Aquitanian, however, ongoing erosion and downcutting in the hinterland caused sediment discharge to the basin to increase and the ratio between the rates of crustal accretion and surface erosion to decrease. The result was a progradation of the dispersal systems, and a shift of the topographic axis towards the distal basin border. The second stage started at ca. 20 Ma at a time when palaeoclimate became more continental, and when the crystalline core became exposed in the orogen. The effect was a decrease in the erosional efficiency of the Swiss Alps and hence a reduction of sediment discharge to the Molasse Basin. We propose that this decrease in sediment flux caused the Burdigalian transgression of the OMM. We also speculate that this reduction of surface erosion initiated the modification of Alpine deformation from vertically- to mainly horizontally directed extrusion (deformation of the Southern Alps, and the Jura Mountains some Ma later). The third stage in the geodynamic development was initiated at the Miocene/Pliocene boundary. At that time, palaeoclimate possibly became wetter, which, in turn, caused surface erosion to increase relative to crustal accretion. This change caused the Alps to

  15. Potential impact of wind energy development of mountain flora and fauna in Rhone-Alpes

    International Nuclear Information System (INIS)

    Ladet, Alain; Bauvet, Corinne

    2005-03-01

    After a presentation of Rhone-Alpes mountain areas (massifs, constraints related to mountain climate, vegetation levels), this report proposes an overview of elements to be taken into account for the development of wind energy. It lists the different concerned public actors, reports a bibliographical study, indicates names and locations of sensitive species (fauna and flora) and natural environments. A synthesis indicates potential impacts, and outlines the patrimonial value, and then proposes an approach for the diagnosis and for the impact study. Appendices notably contain sheets which present the different concerned vegetal or animal species, and their important characteristics in terms of habitat and life

  16. Palaeoenvironmental changes in the Late Triassic (Rhaetian) of the Northern Calcareous Alps

    DEFF Research Database (Denmark)

    Mette, Wolfgang; Elsler, Armin; Korte, Christoph

    2012-01-01

    in the Kössen Formation and determine their significance for environmental and climatic conditions in the Rhaetian sea of the Eiberg Basin (Northern Calcareous Alps). For this purpose 60 δ 18O measurements on 43 articulate brachiopods samples from 8 different horizons were carried out. The results indicate...... to the lowest unit 3 of the Eiberg Member that parallels oxygen isotopes. This positive δ 13C trend is interrupted by a sudden ~1.5‰ negative excursion in the late Rhaetian (Late Rhaetian Event), a time span when the oxygen isotopes remain heavy....

  17. Stars in the Silurian sky: Echinoderm holdfasts from the Carnic Alps, Austria

    Energy Technology Data Exchange (ETDEWEB)

    Ferretti, A.; Ausich, W.I.; Corradini, C.; Corriga, M.G.; Schoenlaub, H.P.

    2016-07-01

    A small collection of echinoderm holdfasts from the Ludlow Cardiola Formation of the Carnic Alps (Austria) contains a wide range of morphologies as a response of environmental adaptation. In general, the holdfasts have a globous and massive dome-like profile with several processes arranged in a sub-radial disposition, so to create a sort of ‘star-like’ outline. A small central depression is common but not present on all specimens. The distinctive holdfasts are preserved in an iron-rich phase, documenting a substitution that has also affected other non-echinoderm calcareous material. (Author)

  18. Risk factors and clinical course of hungry bone syndrome after total parathyroidectomy in dialysis patients with secondary hyperparathyroidism.

    Science.gov (United States)

    Ho, Lo-Yi; Wong, Ping-Nam; Sin, Ho-Kwan; Wong, Yuk-Yi; Lo, Kwok-Chi; Chan, Shuk-Fan; Lo, Man-Wai; Lo, Kin-Yee; Mak, Siu-Ka; Wong, Andrew Kui-Man

    2017-01-10

    Hungry bone syndrome (HBS) is an important postoperative complication after parathyroidectomy for severe secondary hyperparathyroidism (SHPT). There is, however, little data in the literature on its detailed clinical course, and the associated risk factors remain controversial. We did a single-center retrospective study on 62 consecutive dialysis patients who underwent total parathyroidectomy for SHPT to examine the risk factors, clinical course and outcome. Data on demographic characteristics, perioperative laboratory parameters including serum calcium, phosphate, alkaline phosphatase (ALP) and parathyroid hormone (PTH), drug treatment for SHPT and operative details of parathyroidectomy were collected. Seventeen (27.4%) patients developed severe postoperative hypocalcemia with HBS. The serum calcium dropped progressively while serum ALP rose after operation until 2 weeks later when serum calcium reached the trough and serum ALP peaked. Serum phosphate also fell but stabilized between 4 and 14 days. The total postoperative calcium and vitamin D supplementation was significantly larger, and hospital stay was significantly longer in the group with HBS as compared with those without HBS. Young age, high body weight, high preoperative ALP level, and low preoperative calcium level independently predicted the development of HBS while preoperative PTH and use of cinacalcet or paricalcitol did not. HBS was common after total parathyroidectomy in patients with SHPT, and it is important to closely monitor the postoperative serum calcium, phosphate and ALP levels in the following 2 weeks, especially for those at risk. The implications of our findings on perioperative management are discussed.

  19. TAFRO syndrome: New subtype of idiopathic multicentric Castleman disease

    Directory of Open Access Journals (Sweden)

    Gordan Srkalovic

    2017-05-01

    Full Text Available Castleman disease (CD describes a group of three rare and poorly understood lymphoproliferative disorders that have heterogeneous clinical symptoms and common lymph node histopathological features. Unicentric CD (UCD involves a single region of enlarged nodes. Multicentric CD (MCD involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. MCD is further divided into Human Herpes Virus-8 (HHV-8-associated MCD, which occurs in immunocompromised individuals, and HHV-8-negative/idiopathic MCD (iMCD. Recently, iMCD has been further sub-divided into patients with TAFRO syndrome, which involves thrombocytopenia (T, anasarca (A, fevers (F, reticulin myelofibrosis (R, organomegaly (O, and normal or only slightly elevated immunoglobulin levels, and those who do not have TAFRO syndrome. Non-TAFRO iMCD patients typically have thrombocytosis, less severe fluid accumulation, and hypergammaglobulinemia. iMCD patients with TAFRO syndrome may have a worse prognosis, but more research is needed.

  20. ALP gene expression in cDNA samples from bone tissue engineering using a HA/TCP/Chitosan scaffold

    Science.gov (United States)

    Stephanie, N.; Katarina, H.; Amir, L. R.; Gunawan, H. A.

    2017-08-01

    This study examined the potential use of hydroxyapatite (HA)/tricalcium phosphate (TCP)/Chitosan as a bone tissue engineering scaffold. The potential for using HA/TCP/chitosan as a scaffold was analyzed by measuring expression of the ALP osteogenic gene in cDNA from bone biopsies from four Macaque nemestrina. Experimental conditions included control (untreated), treatment with HA/TCP 70:30, HA/TCP 50:50, and HA/TCP/chitosan. cDNA samples were measured quantitively with Real-Time PCR (qPCR) and semi-quantitively by gel electrophoresis. There were no significant differences in ALP gene expression between treatment subjects after two weeks, but the HA/TCP/chitosan treatment gave the highest level of expression after four weeks. The scaffold using the HA/TCP/chitosan combination induced a higher level of expression of the osteogenic gene ALP than did scaffold without chitosan.

  1. United modification of Al-24Si alloy by Al-P and Al-Ti-C master alloys

    Institute of Scientific and Technical Information of China (English)

    韩延峰; 刘相法; 王海梅; 王振卿; 边秀房; 张均艳

    2003-01-01

    The modification effect of a new type of Al-P master alloy on Al-24Si alloys was investigated. It is foundthat excellent modification effect can be obtained by the addition of this new type of A1-P master alloy into Al-24Simelt and the average primary Si grain size is decreased below 47 μm from original 225 μm. It is also found that theTiC particles in the melt coming from Al8Ti2C can improve the modification effect of the Al-P master alloy. Whenthe content of TiC particles in the Al-24Si melt is 0.03 %, the improvement reaches the maximum and keeps steadywith increasing content of TiC particles. Modification effect occurs at 50 min after the addition of the Al-P master al-loy and TiC particles, and keeps stable with prolonging holding time.

  2. Permafrost Favorability Index: Spatial Modeling in the French Alps Using a Rock Glacier Inventory

    Directory of Open Access Journals (Sweden)

    Marco Marcer

    2017-12-01

    Full Text Available In the present study we used the first rock glacier inventory for the entire French Alps to model spatial permafrost distribution in the region. Climatic and topographic data evaluated at the rock glacier locations were used as predictor variables in a Generalized Linear Model. Model performances are strong, suggesting that, in agreement with several previous studies, this methodology is able to model accurately rock glacier distribution. A methodology to estimate model uncertainties is proposed, revealing that the subjectivity in the interpretation of rock glacier activity and contours may substantially bias the model. The model highlights a North-South trend in the regional pattern of permafrost distribution which is attributed to the climatic influences of the Atlantic and Mediterranean climates. Further analysis suggest that lower amounts of precipitation in the early winter and a thinner snow cover, as typically found in the Mediterranean area, could contribute to the existence of permafrost at higher temperatures compared to the Northern Alps. A comparison with the Alpine Permafrost Index Map (APIM shows no major differences with our model, highlighting the very good predictive power of the APIM despite its tendency to slightly overestimate permafrost extension with respect to our database. The use of rock glaciers as indicators of permafrost existence despite their time response to climate change is discussed and an interpretation key is proposed in order to ensure the proper use of the model for research as well as for operational purposes.

  3. Altitude profiles of total chlorinated paraffins in humus and spruce needles from the Alps (MONARPOP)

    Energy Technology Data Exchange (ETDEWEB)

    Iozza, Saverio, E-mail: saverio.iozza@empa.c [Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Analytical Chemistry, Uberlandstrasse 129, CH-8600 Duebendorf (Switzerland); University of Basel, Department of Chemistry, St. Johanns-Ring 19, CH-4056 Basel (Switzerland); Schmid, Peter, E-mail: peter.schmid@empa.c [Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Analytical Chemistry, Uberlandstrasse 129, CH-8600 Duebendorf (Switzerland); Oehme, Michael, E-mail: michael.oehme@unibas.c [University of Basel, Department of Chemistry, St. Johanns-Ring 19, CH-4056 Basel (Switzerland); Bassan, Rodolfo [Regional Agency for Environmental Prevention and Protection of Veneto (Italy); Belis, Claudio [Regional Agency for Environmental Protection of Lombardia (Italy); Jakobi, Gert; Kirchner, Manfred; Schramm, Karl-Werner [GSF-National Research Centre for Environment and Health (Germany); Kraeuchi, Norbert [Swiss Federal Institute for Forest, Snow and Landscape Research (Switzerland); Moche, Wolfgang; Offenthaler, Ivo; Weiss, Peter [Federal Environment Agency Ltd. (Austria); Simoncic, Primoz [Slovenian Forestry Institute (Slovenia); Knoth, Wilhelm [Federal Environment Agency (Germany)

    2009-12-15

    Chlorinated paraffins (CPs) are toxic, bioaccumulative, persistent, and ubiquitously present in the environment. CPs were analyzed in humus and needle samples, which were taken within the Monitoring Network in the Alpine Region for Persistent and other Organic Pollutants (MONARPOP) at sampling sites of 7 different altitude profiles in the Alps. Gas chromatography combined with electron ionization tandem mass spectrometry (EI-MS/MS) was used for the determination of total CPs (sum of short, medium and long chain CPs). CPs were found in all samples; the concentrations varied between 7 and 199 ng g{sup -1} dry weight (dw) and within 26 and 460 ng g{sup -1} dw in humus and needle samples, respectively. A clear vertical tendency within the individual altitude profiles could not be ascertained. Within all altitude profiles, elevated concentrations were observed in humus samples taken between 700 and 900 m and between 1300 and 1500 m. In the needle samples no similar correlation could be observed due to higher variation of the data. - For the first time, CP levels of humus and spruce needle samples from the Alps (MONARPOP) were presented including the evaluation of altitude profiles.

  4. PENGARUH PEMBERIAN SUBKRONIK EKSTRAK KELOPAK BUNGA ROSELLA (Hibiscus Sabdariffa L. TERHADAP KADAR SGPT SGOT DAN ALP

    Directory of Open Access Journals (Sweden)

    Nurkhasanah Nurkhasanah

    2016-11-01

    Full Text Available Roselle (Hibiscus sabdariffa L. has been known as traditional medicinal plants. It needed to evaluate the safety of roselle extract on long-term oral administration. The research aimed to determine the savety of ethanolic extract of roselle calyx. Subchronic toxicity study of ethanolic extract of roselle calyx had been carried out on 60 Sprague Dawleys (SD rats for 28 days. The roselle extract was administered orally every day, with doses of 50,100 and 200 mg/kgBW. There are 2 satellite groups, kept for another 14 days after the treatment in order to detect a delayed occurrence of toxic effect. Satellite group was given extract 200 mg/kgBW for 28 days and followed aquadest treatment for 14 days. At the end of experiment the blood was collected for meansuring SGPT, SGOT and ALP activity. The result showed that treatment of roselle calyx extract had no significant changes in SGPT SGOT, ALP activity. The delayed effect was not also observed. The ethanolic extract of roselle calyx didn’t show toxic effects on the liver on subchronic administration.

  5. Photosynthetic temperature adaptation of Pinus cembra within the timberline ecotone of the Central Austrian Alps.

    Science.gov (United States)

    Wieser, Gerhard; Oberhuber, Walter; Walder, Lisa; Spieler, Daniela; Gruber, Andreas

    2010-04-01

    Temperature is suggested to determine the upper limit of tree life. Therefore, future climate warming may be of importance for tree distribution within the European Alps, where low temperatures limit carbon metabolism.We focused on the effects of air and soil temperature on net photosynthesis (P(n)) of Pinus cembra an evergreen climax species of the timberline ecotone of the Central Austrian Alps. Light response and temperature response curves were estimated along an altitudinal gradient ranging from the forest limit up to the krummholz limit in both summer and fall.In general, P(n) was significantly lower in fall as compared to summer. Nevertheless, independent from season mean P(n) values tended to increase with elevation and were positively correlated with root zone temperatures. The specific leaf area by contrast declined with increasing elevation. Furthermore, the temperature optimum of net photosynthesis declined with increasing elevation and was positively correlated with the mean maximum air temperature of the 10 days prior the date of measurement.Thus, our findings appear to reflect a long-term adaptation of the photosynthetic apparatus of Pinus cembra to the general temperature conditions with respect to elevation combined with a short term acclimation to the prevailing temperature regime.

  6. Link between concentrations of sediment flux and deep crustal processes beneath the European Alps.

    Science.gov (United States)

    Garefalakis, Philippos; Schlunegger, Fritz

    2018-01-09

    Large sediment fluxes from mountain belts have the potential to cause megafans to prograde into the neighbouring sedimentary basins. These mechanisms have been documented based from numerical modelling and stratigraphic records. However, little attention has been focused on inferring temporal changes in the concentrations of supplied sediment from coarse-grained deposits. Here, we extract changes of this variable in the field from a Late Oligocene, c. 4 km-thick suite of fluvial conglomerates situated in the North Alpine foreland basin, which evolved in response to the tectonic and erosional history of the Alps. We measure a decrease in channel depths from >2 m to 20 cm from the base to the top of the suite. These constraints are used to calculate an increase in fan surface slopes from 1.0° based on the Shields criteria for sediment entrainment. We combine slope and bulk grain size data with the Bagnold equation for sediment transport to infer higher concentrations of the supplied sediment. We use these shifts to propose a change towards faster erosion and a steeper landscape in the Alpine hinterland, driven by mantle-scale processes beneath the Alps.

  7. Impacts of climatic change on water and associated economic activities in the Swiss Alps

    Science.gov (United States)

    Beniston, Martin

    2012-01-01

    SummaryThe European Alps are one region of the world where climate-driven changes are already perceptible, as exemplified by the general retreat of mountain glaciers over past decades. Temperatures have risen by up to 2 °C since 1900 particularly at high elevations, a rate that is roughly three times the global-average 20th century warming. Regional climate models suggest that by 2100, winters in Switzerland may warm by 3-5 °C and summers by 6-7 °C according to greenhouse-gas emissions scenarios, while precipitation is projected to increase in winter and sharply decrease in summer. The impacts of these levels of climatic change will affect both the natural environment and a number of economic activities. Alpine glaciers may lose between 50% and 90% of their current volume and the average snowline will rise by 150 m for each degree of warming. Hydrological systems will respond in quantity and seasonality to changing precipitation patterns and to the timing of snow-melt in the Alps, with a greater risk of flooding during the spring and droughts in summer and fall. The direct and indirect impacts of a warming climate will affect key economic sectors such as tourism, hydropower, agriculture and the insurance industry that will be confronted to more frequent natural disasters. This paper will thus provide an overview of the current state of knowledge on climatic change and its impacts on the Alpine world.

  8. An estimate of the glacier ice volume in the Swiss Alps

    Science.gov (United States)

    Farinotti, Daniel; Huss, Matthias; Bauder, Andreas; Funk, Martin

    2009-08-01

    Changes in glacier volume are important for questions linked to sea-level rise, water resource management, and tourism industry. With the ongoing climate warming, the retreat of mountain glaciers is a major concern. Predictions of glacier changes, necessarily need the present ice volume as initial condition, and for transient modelling, the ice thickness distribution has to be known. In this paper, a method based on mass conservation and principles of ice flow dynamics is applied to 62 glaciers located in the Swiss Alps for estimating their ice thickness distribution. All available direct ice thickness measurements are integrated. The ice volumes are referenced to the year 1999 by means of a mass balance time series. The results are used to calibrate a volume-area scaling relation, and the coefficients obtained show good agreement with values reported in the literature. We estimate the total ice volume present in the Swiss Alps in the year 1999 to be 74 ± 9 km 3. About 12% of this volume was lost between 1999 and 2008, whereas the extraordinarily warm summer 2003 caused a volume loss of about 3.5%.

  9. EOCENE LARGER FORAMINIFERAL BIOSTRATIGRAPHY IN THE SOUTHERNMOST DAUPHINOIS DOMAIN (MARITIME ALPS, FRANCE-ITALY BORDER

    Directory of Open Access Journals (Sweden)

    DARIO VARRONE

    2007-07-01

    Full Text Available The Trucco Formation and the Nummulitic Limestone (Dauphinois Domain, Maritime Alps are characterized by abundant larger foraminifera, specifically nummulitids, orthophragminids and encrusting foraminifera. In the Maritime Alps, previous studies suggest a late Lutetian age for the Trucco Formation and a late Lutetian-Priabonian age for the Nummulitic Limestone.Biostratigraphic analysis of the nummulitids, in 11 stratigraphic sections, allowed us to distinguish 3 biozones:MALF1 Zone: defined by the presence of Nummulites brongniarti d’Archiac & Haime, N. puschi d’Archiac, N. perforatus de Montfort, N. striatus (Bruguière, N. cf. dufrenoyi d’Archiac & Haime, N. variolarius/incrassatus and Operculina schwageri Silvestri.MALF2 Zone: defined by the presence of Nummulites perforatus de Montfort, N. striatus (Bruguière, N. cf. dufrenoyi d’Archiac & Haime, N. variolarius/incrassatus and Operculina schwageri Silvestri.MALF 3 Zone: defined by the presence of gr. Nummulites variolarius/incrassatus, N. striatus (Bruguière and Operculina schwageri Silvestri.According to current larger foraminiferal biozonal schemes, the age of these local biozones corresponds to the Bartonian p.p.Moreover, the comparison with biostratigraphic schemes established for the Dauphinois Domain and for the Tethyan area evidences that several typical nummulitid species of the late Bartonian are lacking in the southern Dauphinois Domain, probably due to a paleogeographic control. 

  10. APEX and ALPS, high power density technology programs in the U.S

    International Nuclear Information System (INIS)

    Wong, C.P.C.; Berk, S.; Abdou, M.; Mattas, R.

    1999-02-01

    In fiscal year (FY) 1998 two new fusion technology programs were initiated in the US, with the goal of making marked progress in the scientific understanding of technologies and materials required to withstand high plasma heat flux and neutron wall loads. APEX is exploring new and revolutionary concepts that can provide the capability to extract heat efficiently from a system with high neutron and surface heat loads while satisfying all the fusion power technology requirements and achieving maximum reliability, maintainability, safety, and environmental acceptability. ALPS program is evaluating advanced concepts including liquid surface limiters and divertors on the basis of such factors as their compatibility with fusion plasma, high power density handling capabilities, engineering feasibility, lifetime, safety and R and D requirements. The APEX and ALPS are three-year programs to specify requirements and evaluate criteria for revolutionary approaches in first wall, blanket and high heat flux component applications. Conceptual design and analysis of candidate concepts are being performed with the goal of selecting the most promising first wall, blanket and high heat flux component designs that will provide the technical basis for the initiation of a significant R and D effort beginning in FY2001. These programs are also considering opportunities for international collaborations

  11. A key to larvae of species belonging to the genus Diamesa from Alps and Apennines (Italy

    Directory of Open Access Journals (Sweden)

    Bruno Rossaro

    2015-07-01

    Full Text Available A key to species belonging to the genus Diamesa Meigen, 1835 (Diptera, Chironomidae from the Alps and Apennines (Italy is presented using characters observable in the fourth-instar larva. The larvae are separated on the basis of qualitative and quantitative characters. At present fifteen species from the Italian Alps are described in all three life stages, but only twelve species groups can be separated as larvae. The separation is based on the length and thickness of anal setae, antennal ratio, head capsule color and few other characters of the labrum and mentum. The shape of mental and mandibular teeth is still a valid taxonomic character, but unfortunately these characters can be rarely used because teeth are often excessively worn in samples collected in the field. Quantitative characters show variability within each species, differing according to the duration of larval development and must be used with caution. The species groups which can be separated in the larval stage are: the dampfi group, which includes D. dampfi and D. permacra, the latitarsis group including D. modesta and D. latitarsis, the zernyi group including D. zernyi and D. vaillanti. The species within each of these groups at present cannot be separated. D. starmachi, D. steinboecki, D. goetghebueri, D. bertrami, D. aberrata, D. incallida, D. cinerella, D. tonsa and D. insignipes can be separated from all the other known species in larval stage.

  12. Post transplant lymphoproliferative disease in pediatric solid organ transplant patients: A possible role for [{sup 18}F]-FDG-PET(/CT) in initial staging and therapy monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Falck, C. von [Department of Diagnostic Radiology, Medizinische Hochschule Hannover (Medical School Hanover), Carl-Neuberg-Strasse 1, 30625 Hannover (Germany)], E-mail: Falck.Christian.von@mh-hannover.de; Maecker, B. [Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover (Medical School Hanover), Carl-Neuberg-Strasse 1, 30625 Hannover (Germany); Schirg, E. [Department of Diagnostic Radiology, Medizinische Hochschule Hannover (Medical School Hanover), Carl-Neuberg-Strasse 1, 30625 Hannover (Germany); Boerner, A.R.; Knapp, W.H. [Department of Nuclear Medicine, Medizinische Hochschule Hannover (Medical School Hanover), Carl-Neuberg-Strasse 1, 30625 Hannover (Germany); Klein, C. [Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover (Medical School Hanover), Carl-Neuberg-Strasse 1, 30625 Hannover (Germany); Galanski, M. [Department of Diagnostic Radiology, Medizinische Hochschule Hannover (Medical School Hanover), Carl-Neuberg-Strasse 1, 30625 Hannover (Germany)

    2007-09-15

    Post transplant lymphoproliferative disease (PTLD) is a severe complication after solid organ or bone marrow transplantation. In pediatric transplant recipients PTLD is the most common malignancy. The aim of this study was to evaluate a possible role for positron emission tomography with [{sup 18}F]-2-fluoro-2-desoxy-glucose (FDG) in the initial staging and in therapy monitoring of pediatric patients suffering from biopsy-proven CD20-positive PTLD after solid organ transplantation. Seven pediatric patients were included. All available imaging studies - CT (n = 15), MRI (n = 16) and PET/PETCT (n = 16) - were reviewed on a lesion by lesion base. The performance of FDG-PET in the initial staging and during therapy with a chimeric anti-CD20 antibody was compared to conventional cross sectional imaging and correlated with the clinical outcome. FDG-PET identified all sites of disease as shown by CT/MRI and helped to clarify the significance of equivocal findings. The initial stage of disease was correctly identified by FDG-PET alone when compared to CT/MRI. During therapy, FDG-PET was superior to conventional cross-sectional imaging in the early evaluation of response.

  13. The Role of Antiviral Prophylaxis for the Prevention of Epstein-Barr Virus-Associated Posttransplant Lymphoproliferative Disease in Solid Organ Transplant Recipients: A Systematic Review.

    Science.gov (United States)

    AlDabbagh, M A; Gitman, M R; Kumar, D; Humar, A; Rotstein, C; Husain, S

    2017-03-01

    The role of antiviral prophylaxis for the prevention of posttransplant lymphoproliferative disease (PTLD) remains controversial for solid organ transplantation (SOT) recipients who are seronegative for Epstein-Barr virus (EBV) but who received organs from seropositive donors. We performed a systematic review and meta-analysis to address this issue. Two independent assessors extracted data from studies after determining patient eligibility and completing quality assessments. Overall, 31 studies were identified and included in the quantitative synthesis. Nine studies were included in the direct comparisons (total 2366 participants), and 22 were included in the indirect analysis. There was no significant difference in the rate of EBV-associated PTLD in SOT recipients among those who received prophylaxis (acyclovir, valacyclovir, ganciclovir, valganciclovir) compared with those who did not receive prophylaxis (nine studies; risk ratio 0.95, 95% confidence interval 0.58-1.54). No significant differences were noted across all types of organ transplants, age groups, or antiviral use as prophylaxis or preemptive therapy. There was no significant heterogeneity in the effect of antiviral prophylaxis on the incidence of PTLD. In conclusion, the use of antiviral prophylaxis in high-risk EBV-naive patients has no effect on the incidence of PTLD in SOT recipients. © Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.

  14. Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease.

    Science.gov (United States)

    Minamitani, Takeharu; Ma, Yijie; Zhou, Hufeng; Kida, Hiroshi; Tsai, Chao-Yuan; Obana, Masanori; Okuzaki, Daisuke; Fujio, Yasushi; Kumanogoh, Atsushi; Zhao, Bo; Kikutani, Hitoshi; Kieff, Elliott; Gewurz, Benjamin E; Yasui, Teruhito

    2017-05-02

    Epstein-Barr virus (EBV) is a major cause of immunosuppression-related B-cell lymphomas and Hodgkin lymphoma (HL). In these malignancies, EBV latent membrane protein 1 (LMP1) and LMP2A provide infected B cells with surrogate CD40 and B-cell receptor growth and survival signals. To gain insights into their synergistic in vivo roles in germinal center (GC) B cells, from which most EBV-driven lymphomas arise, we generated a mouse model with conditional GC B-cell LMP1 and LMP2A coexpression. LMP1 and LMP2A had limited effects in immunocompetent mice. However, upon T- and NK-cell depletion, LMP1/2A caused massive plasmablast outgrowth, organ damage, and death. RNA-sequencing analyses identified EBV oncoprotein effects on GC B-cell target genes, including up-regulation of multiple proinflammatory chemokines and master regulators of plasma cell differentiation. LMP1/2A coexpression also up-regulated key HL markers, including CD30 and mixed hematopoietic lineage markers. Collectively, our results highlight synergistic EBV membrane oncoprotein effects on GC B cells and provide a model for studies of their roles in immunosuppression-related lymphoproliferative diseases.

  15. Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    CL Nash

    2000-01-01

    Full Text Available The incidence of post-transplantation lymphoproliferative disorder (PTLD in the adult renal transplant population ranges from 0.7% to 4%. The majority of cases involve a single site and arise, on average, seven months after transplantation. Histopathology usually reveals B-cell proliferative disease and has been standardized into its own classification. Treatment modalities consist of decreased immunosuppression, eradication of Epstein-Barr virus, surgical resection, systemic chemotherapy and monoclonal antibody therapy; however, mortality remains high, typically with a short survival time. In patients who have undergone renal transplantation, approximately 10% of those with PTLDs present with gastrointestinal symptomatology and disease. Reported sites include the stomach, and small and large bowel. Very few cases of Helicobacter pylori or mucosal-associated lymphoid tissue have been described in association with PTLD. In the era of cyclosporine immunosuppression, the incidence of PTLD affecting the gastrointestinal tract may be increasing in comparison with the incidence seen with the use of older immunosuppression regimens. A case of antral PTLD and H pylori infection occurring three months after renal transplantation is presented, and the natural history and management of gastric PTLD are reviewed.

  16. Interleukin-18, Interferon-γ, IP-10, and Mig Expression in Epstein-Barr Virus-Induced Infectious Mononucleosis and Posttransplant Lymphoproliferative Disease

    Science.gov (United States)

    Setsuda, Joyce; Teruya-Feldstein, Julie; Harris, Nancy L.; Ferry, Judith A.; Sorbara, Lynn; Gupta, Ghanshyam; Jaffe, Elaine S.; Tosato, Giovanna

    1999-01-01

    T cell immunodeficiency plays an important role in the pathogenesis of posttransplant lymphoproliferative disease (PTLD) by permitting the unbridled expansion of Epstein-Barr virus (EBV)-infected B lymphocytes. However, factors other than T cell function may contribute to PTLD pathogenesis because PTLD infrequently develops even in the context of severe T cell immunodeficiency, and athymic mice that are T-cell-immunodeficient can reject EBV-immortalized cells. Here we report that PTLD tissues express significantly lower levels of IL-18, interferon-γ (IFN-γ), Mig, and RANTES compared to lymphoid tissues diagnosed with acute EBV-induced infectious mononucleosis, as assessed by semiquantitative RT-PCR analysis. Other cytokines and chemokines are expressed at similar levels. Immunohistochemistry confirmed that PTLD tissues contain less IL-18 and Mig protein than tissues with infectious mononucleosis. IL-18, primarily a monocyte product, promotes the secretion of IFN-γ, which stimulates Mig and RANTES expression. Both IL-18 and Mig display antitumor activity in mice involving inhibition of angiogenesis. These results document greater expression of IL-18, IFN-γ, Mig, and RANTES in lymphoid tissues with acute EBV-induced infectious mononucleosis compared to tissues with PTLD and raise the possibility that these mediators participate in critical host responses to EBV infection. PMID:10393857

  17. Waldenström's macroglobulinemia harbors a unique proteome where Ku70 is severely underexpressed as compared with other B-lymphoproliferative disorders

    International Nuclear Information System (INIS)

    Perrot, A; Pionneau, C; Azar, N; Baillou, C; Lemoine, F M; Leblond, V; Merle-Béral, H; Béné, M-C; Herbrecht, R; Bahram, S; Vallat, L

    2012-01-01

    Waldenström's macroglobulinemia (WM) is a clonal B-cell lymphoproliferative disorder (LPD) of post-germinal center nature. Despite the fact that the precise molecular pathway(s) leading to WM remain(s) to be elucidated, a hallmark of the disease is the absence of the immunoglobulin heavy chain class switch recombination. Using two-dimensional gel electrophoresis, we compared proteomic profiles of WM cells with that of other LPDs. We were able to demonstrate that WM constitutes a unique proteomic entity as compared with chronic lymphocytic leukemia and marginal zone lymphoma. Statistical comparisons of protein expression levels revealed that a few proteins are distinctly expressed in WM in comparison with other LPDs. In particular we observed a major downregulation of the double strand repair protein Ku70 (XRCC6); confirmed at both the protein and RNA levels in an independent cohort of patients. Hence, we define a distinctive proteomic profile for WM where the downregulation of Ku70—a component of the non homologous end-joining pathway—might be relevant in disease pathophysiology

  18. Automated quantification of apoptosis in B-cell chronic lymphoproliferative disorders: a prognostic variable obtained with the Cell-Dyn Sapphire (Abbott) automated hematology analyzer.

    Science.gov (United States)

    Fumi, M; Martins, D; Pancione, Y; Sale, S; Rocco, V

    2014-12-01

    B-chronic lymphocytic leukemia CLL, a neoplastic clonal disorder with monomorphous small B lymphocytes with scanty cytoplasm and clumped chromatin, can be morphologically differentiated in typical and atypical forms with different prognosis: Smudge cells (Gumprecht's shadows) are one of the well-known features of the typical CLL and are much less inconsistent in other different types CLPD. Abbott Cell-Dyn Sapphire uses the fluorescence after staining with the DNA fluorochrome propidium iodide for the measurement of nucleated red blood cells (NRBCs) and nonviable cells (FL3+ cell fraction): We have studied the possible correlation between presence and number of morphologically identifiable smudge cells on smears and the percentage of nonviable cells produced by Cell-Dyn Sapphire. 305 blood samples from 224 patients with B-cell lymphoproliferative disorders and 40 healthy blood donors were analyzed by CBC performed by Cell-Dyn Sapphire, peripheral blood smear, and immunophenotype characterization. FL3+ fraction in CLPD directly correlated with the percentage of smudge cells and is significantly increased in patients with typical B-CLL. This phenomenon is much less evident in patients with atypical/mixed B-CLL and B-NHL. In small laboratories without FCM and cytogenetic, smudge cells%, can be utilized as a preliminary diagnostic and prognostic tool in differential diagnosis of CLPD. © 2014 John Wiley & Sons Ltd.

  19. Epstein-Barr Virus-Positive Extranodal Marginal Zone Lymphoma of Bronchial-Associated Lymphoid Tissue in the Posttransplant Setting: An Immunodeficiency-Related (Posttransplant) Lymphoproliferative Disorder?

    Science.gov (United States)

    Cassidy, Daniel P; Vega, Francisco; Chapman, Jennifer R

    2017-12-20

    Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of hematolymphoid proliferations arising in the context of chronic immunosuppression. The common and indolent B-cell lymphomas, including extranodal marginal zone lymphomas (ENMZLs) of mucosa-associated lymphoid tissue (MALT), are excluded from the category of PTLD in the current World Health Organization classification. We report a case of Epstein-Barr virus (EBV)-positive bronchial-associated lymphoid tissue (BALT) lymphoma involving the lungs of a transplant patient. Aside from history of cardiac transplant, young patient age, and EBV positivity, the histopathologic findings were indistinguishable from usual BALT lymphoma. We review the literature of ENMZL occurring in immunocompromised patients and present this case for consideration that this specific entity is a PTLD. We believe that additional studies might lend strength to the hypothesis that this particular group of EBV-positive, posttransplant ENMZLs merits classification and management as PTLDs. © American Society for Clinical Pathology, 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  20. A meta-analysis of potential relationship between Epstein-Barr-Encoded-RNA (EBER and onset time of post-transplant lymphoproliferative disorders

    Directory of Open Access Journals (Sweden)

    Hossein Khedmat

    2015-01-01

    Full Text Available Epstein-Barr virus (EBV encodes two non-polyadenylated RNAs termed EBV-encoded RNAs (EBERs. In this study, we tried to find series in which data of EBER and onset time of post-transplant lymphoproliferative disorder (PTLD for patients have been documented to conduct a meta-analysis. A comprehensive search of the literature was performed by Pubmed and Google scholar to find reports indicating test results for EBER and PTLD onset in transplant patients. PTLD was considered "early onset" when it develops within the first post-transplant year. Finally, 265 patients from 15 studies have been included in the meta-analysis. The overall meta-analysis also showed a significant relation between EBER test positivity and early-onset PTLD development [relative risk (RR: 1.36; 95% CI: 1.16-1.59; P <0.001]. The i2 index was 49.8%. Our study suggests that PTLD lesions with positive EBER test are more likely to develop within the early post-transplant period. Since early-onset PTLD is supposed to have better prognosis, having a positive EBER test might not be a bad news. However, for having a precise conclusion, prospective studies are needed to be conducted.

  1. The Rhone-Alpes Observatory of Energy and Greenhouse Gases. Key data for 2012, February 2014 release

    International Nuclear Information System (INIS)

    2014-02-01

    Maps, graphs and tables related to greenhouse gas emissions are presented and briefly commented. They illustrate a comparison between the Rhone-Alpes region and France, the European objectives in this region, energy consumption, greenhouse gas emissions, and energy production. They also illustrate an analysis of final energy consumption and greenhouse gas emissions per sector (housing, office building, industry, transports, agriculture, and uses of energy). They present the renewable energy production in Rhone-Alpes: production of electricity from renewable sources, production of renewable heat, carbon sinks

  2. Holothurian sclerites and conodonts in the Upper Carnian (Tuvalian and Norian Limestones in the Central Kanmik Alps

    Directory of Open Access Journals (Sweden)

    Anton Ramovš

    1992-12-01

    Full Text Available Near Bivouac under the Skuta Mountain (locality 1 in the central Kamnik Alps Upper Carnian Limestones were determined with conodont Epigondolella nodosa Hayashi, holothurian sclerites Calclamnella consona Mostler and C. regularis Stefanov, ammonites and other fossils similar to deeper marine Hallstatt facies of Northern Limestone Alps.Conodonts Epigondolella abneptis (Huckriede and very rich holothurian fauna proved the Norian age for bedded limestones with very frequent large chert nodules on the south slope of the Skuta and on Sleme (loc. 2 and 3. They representdeeper marine facies and a distinct development of the Lower Norian

  3. Cushing's Syndrome

    Science.gov (United States)

    Cushing's syndrome is a hormonal disorder. The cause is long-term exposure to too much cortisol, a hormone that ... your body to make too much cortisol. Cushing's syndrome is rare. Some symptoms are Upper body obesity ...

  4. Usher Syndrome

    Science.gov (United States)

    Usher syndrome is an inherited disease that causes serious hearing loss and retinitis pigmentosa, an eye disorder that causes ... and vision. There are three types of Usher syndrome: People with type I are deaf from birth ...

  5. Metabolic Syndrome

    Science.gov (United States)

    Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. These conditions ... agree on the definition or cause of metabolic syndrome. The cause might be insulin resistance. Insulin is ...

  6. Reye Syndrome

    Science.gov (United States)

    Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently ... a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, ...

  7. Rett Syndrome

    Science.gov (United States)

    Rett syndrome is a rare genetic disease that causes developmental and nervous system problems, mostly in girls. It's related to autism spectrum disorder. Babies with Rett syndrome seem to grow and develop normally at first. ...

  8. Caplan syndrome

    Science.gov (United States)

    ... enable JavaScript. Rheumatoid pneumoconiosis (RP; also known as Caplan syndrome) is swelling (inflammation) and scarring of the ... avoid exposure to inorganic dust. Alternative Names RP; Caplan syndrome; Pneumoconiosis - rheumatoid; Silicosis - rheumatoid pneumoconiosis; Coal worker's ...

  9. Turner Syndrome

    Science.gov (United States)

    Turner syndrome is a genetic disorder that affects a girl's development. The cause is a missing or incomplete ... t work properly. Other physical features typical of Turner syndrome are Short, "webbed" neck with folds of skin ...

  10. Gardner's syndrome

    International Nuclear Information System (INIS)

    Sobrado Junior, C.W.; Bresser, A.; Cerri, G.G.; Habr-Gama, A.; Pinotti, H.W.; Magalhaes, A.

    1988-01-01

    A case of familiar poliposis of colon related to a right mandibular osteoma is reported (this association is usually called Gardner's syndrome). Radiologic pictures ae shown and some commentaries about this syndrome concerning the treatment are made. (author) [pt

  11. Sotos Syndrome

    Science.gov (United States)

    ... Clinical Trials Organizations Publications Definition Sotos syndrome (cerebral gigantism) is a rare genetic disorder caused by mutation ... have also been reported. × Definition Sotos syndrome (cerebral gigantism) is a rare genetic disorder caused by mutation ...

  12. Felty syndrome

    Science.gov (United States)

    Seropositive rheumatoid arthritis (RA); Felty's syndrome ... The cause of Felty syndrome is unknown. It is more common in people who have had rheumatoid arthritis (RA) for a long time. People with ...

  13. Bartter syndrome

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000308.htm Bartter syndrome To use the sharing features on this page, please enable JavaScript. Bartter syndrome is a group of rare conditions that affect ...

  14. Pendred Syndrome

    Science.gov (United States)

    ... other possible long-term consequences of the syndrome. Children with Pendred syndrome should start early treatment to gain communication skills, such as learning sign language or cued speech or learning to ...

  15. Dravet Syndrome

    Science.gov (United States)

    ... and supports a broad program of basic and clinical research on all types of epilepsy, including Dravet syndrome. Study of the genetic defects responsible for Dravet syndrome and related ... Publications Definition Dravet ...

  16. Industrial applications of solar energy: deserts, seas, the Alps; Les applications industrielles de l'energie solaire: du desert aux Alpes en passant par la mer

    Energy Technology Data Exchange (ETDEWEB)

    Allani, Y.

    2008-07-01

    In this set of presentation slides, after a review of worldwide energy resources the author presents his innovative technical solution aimed at contributing to future energy supply. An extra-flat solar concentrator was developed to produce industrial steam in the temperature range 150 to 300 {sup o}C. A prototype was operated on the site of the Federal Institute of Technology (EPFL) in Lausanne, Switzerland, for power generation at 12 kW{sub el}. In Ras al Khaimah, United Arab Emirates, the concept of the so-called Solar Island is to be tested. Construction work is underway. A floating circular platform will be equipped with parallel rows of extra-flat solar concentrators. The platform will rotate to follow the sun apparent movement and enhance the power output of the concentrators. A second project is presented that should be realised in the Swiss Alps. In this case the extra-flat concentrators will be mounted on existing steel constructions that prevent snow avalanches on steep grounds. The basic technical data of the two projects are given.

  17. Down Syndrome

    Science.gov (United States)

    ... Down syndrome increases as a woman gets older. Down syndrome cannot be cured. Early treatment programs can help improve skills. They may include ... occupational, and/or educational therapy. With support and treatment, many ... Down syndrome live happy, productive lives. NIH: National Institute of ...

  18. Rowell syndrome

    Directory of Open Access Journals (Sweden)

    Ramesh Y Bhat

    2014-01-01

    Full Text Available Rowell syndrome is a rare disease consisting of erythema multiforme-like lesions associated with lupus erythematosus. The syndrome occurs mostly in middle-aged women. The authors describe the syndrome in a 15-year-old boy who responded well to systemic steroids and hydroxychloroquine.

  19. Aicardi Syndrome

    Science.gov (United States)

    ... from Aicardi-Goutieres syndrome, which is an inherited encephalopathy that affects newborn infants.) × Definition Aicardi syndrome is a rare genetic ... from Aicardi-Goutieres syndrome, which is an inherited encephalopathy that affects newborn infants.) View Full Definition Treatment There is no ...

  20. Purification of barley dimeric α-amylase inhibitor-1 (BDAI-1) and avenin-like protein-a (ALP) from beer and their impact on beer foam stability.

    Science.gov (United States)

    Iimure, Takashi; Kihara, Makoto; Sato, Kazuhiro; Ogushi, Kensuke

    2015-04-01

    Foam stability is a key factor of beer quality for consumers and brewers. Recent beer proteome analyses have suggested that barley dimeric α-amylase inhibitor-1 (BDAI-1) and avenin-like protein-a (ALP) derived from barley are important for beer foam stability. In this study, BDAI-1 and ALP were purified from a Japanese commercial beer sample using salt precipitation and column chromatography. The purification level was verified using two-dimensional gel electrophoresis, mass spectrometry, and database searches. Purified BDAI-1 and ALP were added to a beer sample to compare the foam stability to that of a control beer sample. As a result, beer foam stability was significantly improved by BDAI-1 but not by ALP, thereby suggesting that BDAI-1 affects beer foam stability whereas ALP does not. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Sjögren syndrome presenting with hypopotassemic periodic paralysis due to renal tubular acidosis

    Science.gov (United States)

    Ataoglu, Esra Hayriye; Demir, Betul; Tuna, Mazhar; Çavus, Bilger; Cetin, Faik; Temiz, Levent Umit; Ozturk, Savas; Yenigun, Mustafa

    2012-01-01

    Summary Background: Sjögren syndrome (SS) is an autoimmune-lymphoproliferative disorder characterized by mononuclear cell infiltration of exocrine glands. Clinically, Sjögren syndrome (SS) has a wide spectrum, varying from autoimmune exocrinopathy to systemic involvement. There have been few cases reporting that primary SS developed with distal renal tubular acidosis clinically. Case Report: Here, we present a case with primary Sjögren syndrome accompanied by hypopotassemic paralysis due to renal tubular acidosis. Severe hypopotassemia, hyperchloremic metabolic acidosis, alkaline urine and disorder in urinary acidification test were observed in the biochemical examination of the 16-year-old female patient, who had applied to our clinic for extreme loss of muscle force. After the examinations it was determined that the patient had developed Type 1 RTA (distal RTA) due to primary Sjögren syndrome. Potassium and alkaline replacement was made and an immediate total recovery was achieved. Conclusions: Hypopotassemic paralysis due to primary Sjögren syndrome is a rare but severe disorder that could lead to death if not detected early and cured appropriately. Thus, effective treatment should be immediately initiated in cases where severe hypopotassemia is accompanied by metabolic acidosis, and the cases should also be examined for extraglandular involvement of SS. PMID:23569525

  2. The Origin of The Piz Terri-Lunschania zone (Central Alps, Switzerland)

    Science.gov (United States)

    Galster, Federico; Stockli, Daniel

    2017-04-01

    The Piz Terri-Lunschania zone (PTLZ) represents a band of metasedimentary rocks embedded in a crucial knot at the NE border of the Lepontine dome, at the intersection of the Gotthard, Lucomagno, Simano, Adula and Grava nappes. Its origin and its position in the tectonostratigraphy of the Central Alps are still not completely understood. A better understanding of this sedimentary zone and its tectonic position could shed lights on the Helvetic-Penninic connection and facilitate the disentanglement of the Lepontine dome tectonics. In this study we combine structural and stratigraphic observations with detrital zircon (DZ) and detrital rutile (DR) U-Pb geochronology as well as mineral trace element data from Permian, Triassic and Jurassic sandstones. We compare these data with those from adjacent tectonic units and coeval strata in other portions of the Alpine chain. Maximal depositional ages, abrupt changes in provenances and stratigraphic correlations based on new DZ and DR U-Pb and trace element data allow for a better understanding of the sedimentary evolution of the Terri basin and its palaeogeographic position along the northern margin of the Alpine Tethys. In particular the DZ U-Pb signatures, with its abundant 260-280 Ma zircons and the scarcity of 290-350 Ma zircons, corroborates an Ultra-Adula origin of the PTLZ as proposed by Galster et al (2010; 2012) based on stratigraphic arguments and reinforces the notion of a Briançonnais influence on the stratigraphic record of this complex zone, a fact that has important tectonic and Palaeogeographic implications. Galster F, Cavargna-Sani M, Epard J-L, Masson H (2012) New stratigraphic data from the Lower Penninic between the Adula nappe and the Gotthard massif and consequences for the tectonics and the paleogeography of the Central Alps. Tectonophysics 579:37-55. doi: 10.1016/j.tecto.2012.05.029 Galster F, Epard J-L, Masson H (2010) The Soja and Luzzone-Terri nappes: Discovery of a Briançonnais element below the

  3. Time constraints for post-LGM landscape response to deglaciation in Val Viola, Central Italian Alps

    Science.gov (United States)

    Scotti, Riccardo; Brardinoni, Francesco; Crosta, Giovanni Battista; Cola, Giuseppe; Mair, Volkmar

    2017-12-01

    Across the northern European Alps, a long tradition of Quaternary studies has constrained post-LGM (Last Glacial Maximum) landscape history. The same picture remains largely unknown for the southern portion of the orogen. In this work, starting from existing 10Be exposure dating of three boulders in Val Viola, Central Italian Alps, we present the first detailed, post-LGM reconstruction of landscape (i.e., glacial, periglacial and paraglacial) response south of the Alpine divide. We pursue this task through Schmidt-hammer exposure-age dating (SHD) at 34 sites including moraines, rock glaciers, protalus ramparts, rock avalanche deposits and talus cones. In addition, based on the mapping of preserved moraines and on the numerical SHD ages, we reconstruct the glacier extent of four different stadials, including Egesen I (13.1 ± 1.1 ka), Egesen II (12.3 ± 0.6 ka), Kartell (11.0 ± 1.4 ka) and Kromer (9.7 ± 1.4 ka), whose chronologies agree with available counterparts from north of the Alpine divide. Results show that Equilibrium Line Altitude depressions (ΔELAs) associated to Younger Dryas and Early Holocene stadials are smaller than documented at most available sites in the northern Alps. These findings not only support the hypothesis of a dominant north westerly atmospheric circulation during the Younger Dryas, but also suggest that this pattern could have lasted until the Early Holocene. SHD ages on rock glaciers and protalus ramparts indicate that favourable conditions to periglacial landform development occurred during the Younger Dryas (12.7 ± 1.1 ka), on the valley slopes above the glacier, as well as in newly de-glaciated areas, during the Early Holocene (10.7 ± 1.3 and 8.8 ± 1.8 ka). The currently active rock glacier started to develop before 3.7 ± 0.8 ka and can be associated to the Löbben oscillation. Four of the five rock avalanches dated in Val Viola cluster within the Early Holocene, in correspondence of an atmospheric warming phase. By contrast

  4. Late Pleistocene - Holocene surface processes and landscape evolution in the central Swiss Alps

    Science.gov (United States)

    Boxleitner, Max; Musso, Alessandra; Waroszewski, Jarosław; Malkiewicz, Małgorzata; Maisch, Max; Dahms, Dennis; Brandová, Dagmar; Christl, Marcus; de Castro Portes, Raquel; Egli, Markus

    2017-10-01

    The European Alps are a geomorphologically active region and experience a number of gravity-driven hillslope processes. Soil and landscape formation in the Alps has consequently undergone several minor and major traceable changes of developmental trajectories during the Holocene. Soil development is hypothesised to be often non-linear with time and characterised by stages of progressive and regressive evolution caused by upbuilding (formation, profile deepening) and erosion (profile shallowing). Several cold and warm climate phases are identified during the Holocene but it is largely unknown which effects these might have had on slope processes. By using datable moraines (10Be) and mires (14C), we have constructed a temporal framework for these processes. Using the geochemical imprint of mires in the Alpine setting of the Göschener-valley of the Central Swiss Alps, we reconstructed general (mostly erosional) landscape processes for the last ca. 10 ka. As this is the type locality for the Göschener cold phase, we assumed that this phase (Göschener cold phase I and II 1.5 and 2.5 ka BP) should have left easily recognizable traits. After deglaciation (11-12 ka BP), soil evolution was progressive. Beginning around 8 ka BP, we detect a distinct increase in erosion here, together with a vegetation change (towards tundra vegetation) and the highest measured rates of carbon sequestration. Other phases of high geomorphic activity were recognised ca. 5-6 ka BP, 4 ka BP and, to a lesser extent, 1-3 ka ago. The cold phase at 5-6 ka BP corresponds to a less distinct change in vegetation and lessened erosion. Human impact is increasingly obvious since about 2.4 ka BP which overlaps with the Göschener cold phase. Nonetheless, erosion processes were not extraordinarily high during this period and a climate effect cannot be distinguished. We detect evidence of increasing human disturbance (regressive soil evolution) for about the last 1 ka. We also detect an increase in dust

  5. Dravets syndrom

    DEFF Research Database (Denmark)

    Hansen, Lars Kjaersgård; Rasmussen, Niels Henrik; Ousager, Lilian Bomme

    2010-01-01

    Dravet syndrome is an epileptic syndrome of infancy and early childhood. Most cases of Dravet syndrome seem to be due to a genetic defect causing the sodium channel to malfunction. We describe the main features of the syndrome. This epilepsy is medically intractable, but we call attention...... to the fact that some medications are of benefit and some could exacerbate the condition. Early recognition of the syndrome including by genetic testing could possibly improve outcome and reduce the need for other specialized investigations. Udgivelsesdato: 2010-Feb-22...

  6. Angelo Sismonda (1807–1878), pioneer of geological mapping in the Alps of Savoy and the Piedmont: a bibliography

    CERN Document Server

    Hollier, John; Basaglia, Tullio; Hollier, Anita

    2016-01-01

    Angelo Sismonda (Ange Sismonda) was an Italian mineralogist and geologist based in Turin during the Risorgimento who produced pioneering maps of the Alps in the Kingdom of Sardinia. Well known during his lifetime, he is now mentioned only in passing by historians and no comprehensive bibliography of his work exists. To render his work more accessible, we present a short biography and a bibliography.

  7. The AlpArray Seismic Network: A Large-Scale European Experiment to Image the Alpine Orogen

    Science.gov (United States)

    Hetényi, György; Molinari, Irene; Clinton, John; Bokelmann, Götz; Bondár, István; Crawford, Wayne C.; Dessa, Jean-Xavier; Doubre, Cécile; Friederich, Wolfgang; Fuchs, Florian; Giardini, Domenico; Gráczer, Zoltán; Handy, Mark R.; Herak, Marijan; Jia, Yan; Kissling, Edi; Kopp, Heidrun; Korn, Michael; Margheriti, Lucia; Meier, Thomas; Mucciarelli, Marco; Paul, Anne; Pesaresi, Damiano; Piromallo, Claudia; Plenefisch, Thomas; Plomerová, Jaroslava; Ritter, Joachim; Rümpker, Georg; Šipka, Vesna; Spallarossa, Daniele; Thomas, Christine; Tilmann, Frederik; Wassermann, Joachim; Weber, Michael; Wéber, Zoltán; Wesztergom, Viktor; Živčić, Mladen

    2018-04-01

    The AlpArray programme is a multinational, European consortium to advance our understanding of orogenesis and its relationship to mantle dynamics, plate reorganizations, surface processes and seismic hazard in the Alps-Apennines-Carpathians-Dinarides orogenic system. The AlpArray Seismic Network has been deployed with contributions from 36 institutions from 11 countries to map physical properties of the lithosphere and asthenosphere in 3D and thus to obtain new, high-resolution geophysical images of structures from the surface down to the base of the mantle transition zone. With over 600 broadband stations operated for 2 years, this seismic experiment is one of the largest simultaneously operated seismological networks in the academic domain, employing hexagonal coverage with station spacing at less than 52 km. This dense and regularly spaced experiment is made possible by the coordinated coeval deployment of temporary stations from numerous national pools, including ocean-bottom seismometers, which were funded by different national agencies. They combine with permanent networks, which also required the cooperation of many different operators. Together these stations ultimately fill coverage gaps. Following a short overview of previous large-scale seismological experiments in the Alpine region, we here present the goals, construction, deployment, characteristics and data management of the AlpArray Seismic Network, which will provide data that is expected to be unprecedented in quality to image the complex Alpine mountains at depth.

  8. Anomalous directional behaviour of the real parts of the induction arrows in the Eastern Alps. Tectonic and palaeographical implications

    Energy Technology Data Exchange (ETDEWEB)

    Gurk, M.; Schnegg, P.-A. [Universite' de Neuchatel, Groupe de Geomagnetisme, Institut de Geologie, Neuchatel (Switzerland)

    2001-08-01

    The electromagnetic induction pattern in the Eastern Alps is characterised by a (continuous) large-scale zone on which the real parts of the induction arrows show anomalous directional behaviour. This zone extends from the Penninic Domain of Eastern Switzerland (Graubuenden) probably into the Carpathian ranges. A coarse mesh of a Magnetotelluric (MT) and Geomagnetic Deep Sounding (GDS) station in the Alps of Graubuenden and Valais (Western Switzerland) indicates that this electromagnetic anomaly is restricted to the Mesozoic sediments of the North Penninic Buendnerschiefer-facies that begins in Eastern Switzerland and extends towards the east beneath Austroalpine, South Penninic and Southalpine units. Striking similarities in position and arrangement between this zone and the magnetic signature in Eastern Alps are found. The analysis of the GDS data with the method of the Hypothetical Event Analysis (HEA) shows that current channelling affects the electromagnetic fields in this zone and causes the anomalous direction of induction arrows. Based on the combined interpretation of GDS data from the Eastern Alps and West Hungary together with the recent data from Switzerland, the following geological implications are discussed: i) a spatial decoupling of induction processes from the upper to the lower crust; ii) a lower crustal conductive structure caused by the identification of the Northern Adriatic promontory or terrane; iii) the eastward continuation of the Buendnerschiefer-facies at least to the tectonic window of Rechnitz.

  9. Altitudinal and chiral signature of persistent organochlorine pesticides in air, soil, and spruce needles (Picea abies) of the Alps.

    Science.gov (United States)

    Shen, Heqing; Henkelmann, Bernhard; Levy, Walkiria; Zsolnay, Adam; Weiss, Peter; Jakobi, Gert; Kirchner, Manfred; Moche, Wolfgang; Braun, Katharina; Schramm, Karl-Werner

    2009-04-01

    The present study investigated the distribution, transportation, and biodegradation of the selected chiral persistent organochlorine pesticides (OCP) in the Alps. In the complex environment, we found the movement and fate of OCP could be defined by many factors. Taking HCE as an example, below the timberline its accumulation from air into SPMD increased with altitude and seasonally changed, but the trends reversed above the timberline. In soil, the tendency of HCE concentrations vs organic materials followed a sigmoid curve, and HCE concentration-altitude correlations are positive in central Alps but negative in southern Alps. The HCE enantiomeric ratios (ERs) in soil correlated to HCE isomers concentrations, the humus pH values, and the sampling site altitudes. HCE shift from humus to mineral soil can also be traced by ERs. The altitudinal and longitudinal trends in needles suggested that alpha-HCH has a more complex movementthan HCE in Alps. In conclusion, altitude conducted condensation, plant canopies, organic material in soil, and geographic specific precipitations may affect OCP distributions and transportation, whereas altitude conducted temperature and soil pH could dictate their fate in the environment.

  10. Anomalous directional behaviour of the real parts of the induction arrows in the Eastern Alps. Tectonic and palaeographical implications

    International Nuclear Information System (INIS)

    Gurk, M.; Schnegg, P.-A.

    2001-01-01

    The electromagnetic induction pattern in the Eastern Alps is characterised by a (continuous) large-scale zone on which the real parts of the induction arrows show anomalous directional behaviour. This zone extends from the Penninic Domain of Eastern Switzerland (Graubuenden) probably into the Carpathian ranges. A coarse mesh of a Magnetotelluric (MT) and Geomagnetic Deep Sounding (GDS) station in the Alps of Graubuenden and Valais (Western Switzerland) indicates that this electromagnetic anomaly is restricted to the Mesozoic sediments of the North Penninic Buendnerschiefer-facies that begins in Eastern Switzerland and extends towards the east beneath Austroalpine, South Penninic and Southalpine units. Striking similarities in position and arrangement between this zone and the magnetic signature in Eastern Alps are found. The analysis of the GDS data with the method of the Hypothetical Event Analysis (HEA) shows that current channelling affects the electromagnetic fields in this zone and causes the anomalous direction of induction arrows. Based on the combined interpretation of GDS data from the Eastern Alps and West Hungary together with the recent data from Switzerland, the following geological implications are discussed: i) a spatial decoupling of induction processes from the upper to the lower crust; ii) a lower crustal conductive structure caused by the identification of the Northern Adriatic promontory or terrane; iii) the eastward continuation of the Buendnerschiefer-facies at least to the tectonic window of Rechnitz

  11. Jasrouxite, a new Pb-Ag-As-Sb member of the lillianite homologous series from Jas Roux, Hautes Alpes, France

    DEFF Research Database (Denmark)

    Topa, Dan; Makovicky, Emil; Favreau, Georges

    2013-01-01

    The thallium-rich sulfosalt deposit of Jas Roux, situated in the Pelvoux Massif (Hautes-Alpes de´partement, France), occurs in a Triassic sedimentary series. Jasrouxite belongs to the early lead-containing stages of the Tl–As–Sb period of mineralization. It occurs in a silicified gangue, along wi...

  12. Anomalous directional behaviour of the real parts of the induction arrows in the Eastern Alps: tectonic and palaeogeographic implications

    Directory of Open Access Journals (Sweden)

    P. A. Schnegg

    2001-06-01

    Full Text Available The electromagnetic induction pattern in the Eastern Alps is characterised by a (continuous large-scale zone on which the real parts of the induction arrows show anomalous directional behaviour. This zone extends from the Penninic Domain of Eastern Switzerland (Graubünden probably into the Carpathian ranges. A coarse mesh of a Magnetotelluric (MT and Geomagnetic Deep Sounding (GDS station in the Alps of Graubünden and Valais (Western Switzerland indicates that this electromagnetic anomaly is restricted to the Mesozoic sediments of the North Penninic Bündnerschiefer-facies that begins in Eastern Switzerland and extends towards the east beneath Austroalpine, South Penninic and Southalpine units. Striking similarities in position and arrangement between this zone and the magnetic signature in the Eastern Alps are found. The analysis of the GDS data with the method of the Hypothetical Event Analysis (HEA shows that current channelling affects the electromagnetic fields in this zone and causes the anomalous direction of induction arrows. Based on the combined interpretation of GDS data from the Eastern Alps and West Hungary together with our recent data from Switzerland, the following geological implications are discussed: i a spatial decoupling of induction processes from the upper to the lower crust; ii a lower crustal conductive structure caused by the indentation of the Northern Adriatic promontory or terrane; iii the eastward continuation of the Bündnerschiefer-facies at least to the tectonic window of Rechnitz.

  13. [Application of Bayes Probability Model in Differentiation of Yin and Yang Jaundice Syndromes in Neonates].

    Science.gov (United States)

    Mu, Chun-sun; Zhang, Ping; Kong, Chun-yan; Li, Yang-ning

    2015-09-01

    To study the application of Bayes probability model in differentiating yin and yang jaundice syndromes in neonates. Totally 107 jaundice neonates who admitted to hospital within 10 days after birth were assigned to two groups according to syndrome differentiation, 68 in the yang jaundice syndrome group and 39 in the yin jaundice syndrome group. Data collected for neonates were factors related to jaundice before, during and after birth. Blood routines, liver and renal functions, and myocardial enzymes were tested on the admission day or the next day. Logistic regression model and Bayes discriminating analysis were used to screen factors important for yin and yang jaundice syndrome differentiation. Finally, Bayes probability model for yin and yang jaundice syndromes was established and assessed. Factors important for yin and yang jaundice syndrome differentiation screened by Logistic regression model and Bayes discriminating analysis included mothers' age, mother with gestational diabetes mellitus (GDM), gestational age, asphyxia, or ABO hemolytic diseases, red blood cell distribution width (RDW-SD), platelet-large cell ratio (P-LCR), serum direct bilirubin (DBIL), alkaline phosphatase (ALP), cholinesterase (CHE). Bayes discriminating analysis was performed by SPSS to obtain Bayes discriminant function coefficient. Bayes discriminant function was established according to discriminant function coefficients. Yang jaundice syndrome: y1= -21. 701 +2. 589 x mother's age + 1. 037 x GDM-17. 175 x asphyxia + 13. 876 x gestational age + 6. 303 x ABO hemolytic disease + 2.116 x RDW-SD + 0. 831 x DBIL + 0. 012 x ALP + 1. 697 x LCR + 0. 001 x CHE; Yin jaundice syndrome: y2= -33. 511 + 2.991 x mother's age + 3.960 x GDM-12. 877 x asphyxia + 11. 848 x gestational age + 1. 820 x ABO hemolytic disease +2. 231 x RDW-SD +0. 999 x DBIL +0. 023 x ALP +1. 916 x LCR +0. 002 x CHE. Bayes discriminant function was hypothesis tested and got Wilks' λ =0. 393 (P =0. 000). So Bayes

  14. Anthocyanin Profile in Berries of Wild and Cultivated Vaccinium spp. along Altitudinal Gradients in the Alps.

    Science.gov (United States)

    Zoratti, Laura; Jaakola, Laura; Häggman, Hely; Giongo, Lara

    2015-10-07

    Vaccinium spp. berries provide some of the best natural sources of anthocyanins. In the wild bilberry (Vaccinium myrtillus L.), a clear increasing trend in anthocyanin biosynthesis has been reported toward northern latitudes of Europe, but studies related to altitude have given contradictory results. The present study focused on the anthocyanin composition in wild bilberries and highbush blueberry (Vaccinium corymbosum L. cv. Brigitta Blue) growing along altitudinal gradients in the Alps of northern Italy. Our results indicate an increasing accumulation of anthocyanins in bilberries along an altitudinal gradient of about 650 m. The accumulation was due to a significant increase in delphinidin and malvidin glycosides, whereas the accumulation of cyanidin and peonidin glycosides was not affected by altitude. Seasonal differences, especially temperature, had a major influence on the accumulation of anthocyanins in blueberries.

  15. Frequent floods in the European Alps coincide with cooler periods of the past 2500 years.

    Science.gov (United States)

    Glur, Lukas; Wirth, Stefanie B; Büntgen, Ulf; Gilli, Adrian; Haug, Gerald H; Schär, Christoph; Beer, Jürg; Anselmetti, Flavio S

    2013-09-26

    Severe floods triggered by intense precipitation are among the most destructive natural hazards in Alpine environments, frequently causing large financial and societal damage. Potential enhanced flood occurrence due to global climate change would thus increase threat to settlements, infrastructure, and human lives in the affected regions. Yet, projections of intense precipitation exhibit major uncertainties and robust reconstructions of Alpine floods are limited to the instrumental and historical period. Here we present a 2500-year long flood reconstruction for the European Alps, based on dated sedimentary flood deposits from ten lakes in Switzerland. We show that periods with high flood frequency coincide with cool summer temperatures. This wet-cold synchronism suggests enhanced flood occurrence to be triggered by latitudinal shifts of Atlantic and Mediterranean storm tracks. This paleoclimatic perspective reveals natural analogues for varying climate conditions, and thus can contribute to a better understanding and improved projections of weather extremes under climate change.

  16. Dating emplacement and evolution of the orogenic magmatism in the internal Western Alps

    DEFF Research Database (Denmark)

    Berger, Alfons; Thomsen, Tonny B.; Ovtcharova, Maria

    2012-01-01

    The Canavese Line in the Western Alps represents the position in the Alpine chain, where alkaline and calc-alkaline magmatism occur in close spatial and temporal association. In addition to available data on the alkaline Valle del Cervo Pluton, we present petrological and geochemical data...... on the Miagliano tonalite. The latter is of special interest, because it is located in the south-eastern side of the Canavese Line, in contrast to most Periadriatic Plutons. The dioritic to tonalitic rocks of the Miagliano Pluton represent an intermediate stage of a calc-alkaline differentiation, demonstrated...... by relics of two different pyroxenes as well as the texture of allanite. Hornblende barometry indicates pressures of similar to 0.46 GPa consistent with the presence of magmatic epidote. Field relationships between the two Plutons, the volcanic and volcaniclastic rocks of the Biella Volcanic Suite...

  17. 25th Conference on Robotics in Alpe-Adria-Danube Region

    CERN Document Server

    Borangiu, Theodor

    2017-01-01

    This book presents the proceedings of the 25th International Conference on Robotics in Alpe-Adria-Danube Region, RAAD 2016 held in Belgrade, Serbia, on June 30th–July 2nd, 2016. In keeping with the tradition of the event, RAAD 2016 covered all the important areas of research and innovation in new robot designs and intelligent robot control, with papers including Intelligent robot motion control; Robot vision and sensory processing; Novel design of robot manipulators and grippers; Robot applications in manufacturing and services; Autonomous systems, humanoid and walking robots; Human–robot interaction and collaboration; Cognitive robots and emotional intelligence; Medical, human-assistive robots and prosthetic design; Robots in construction and arts, and Evolution, education, legal and social issues of robotics. For the first time in RAAD history, the themes cloud robots, legal and ethical issues in robotics as well as robots in arts were included in the technical program. The book is a valuable resource f...

  18. A NEW DAONELLA FROM THE LADINIAN PLATFORM OF THE ESINO LIMESTONE (SOUTHERN ALPS, ITALY

    Directory of Open Access Journals (Sweden)

    CRISTIANO LARGHI

    2006-03-01

    Full Text Available The bivalve Daonella Mojsisovics, 1874 is very common in the Middle Triassic pelagic facies, whereas the record of this genus from shallow water limestones is rare. In the present paper a new species of Daonella, named D. pseudograbensis, is described from the Esino Limestone, a Ladinian (Middle Triassic carbonate platform in the central Southern Alps. The species is described from Brembana Valley, where the Esino Limestone is rather rich in bioclastic lenses yielding faunas with bivalves, cephalopods, gastropods, brachiopods, corals and calcareous algae. Daonella pseudograbensis n. sp. is based on very well preserved specimens, which are often articulated and closed, all coming from the same locality. The new species shows a narrow range of intraspecific and ontogenetic morphologic variations. It is easy distinguishable from the other species of the genus for the outline and ornamentation; it therefore differs from D. grabensis Kittl, 1912, the most similar species, for the longer anterior dorsal margin.Pdf

  19. Resonant laser power build-up in ALPS. A 'light-shining-through-walls' experiment

    International Nuclear Information System (INIS)

    Ehret, Klaus; Ghazaryan, Samvel; Frede, Maik

    2009-05-01

    The ALPS collaboration runs a light-shining-through-walls (LSW) experiment to search for photon oscillations into weakly interacting sub-eV particles (WISPs) inside of a superconducting HERA dipole magnet at the site of DESY. In this paper we report on the first successful integration of a large-scale optical cavity to boost the available power for WISP production in this type of experiments. The key elements are a frequency tunable narrow line-width continuous wave laser acting as the primary light source and an electronic feed-back control loop to stabilize the power build-up. We describe and characterize our apparatus and demonstrate the data analysis procedures on the basis of a brief exemplary run. (orig.)

  20. The ozone pollution and the climatology in a Mediterranean space: the Alpes-Maritimes

    International Nuclear Information System (INIS)

    Martin, N.

    2008-12-01

    The tropospheric ozone, secondary pollutant affecting the health of the human beings, concerns particularly the department of the Alpes-Maritimes during the photochemical season. Mountainous littoral space, this territory is widely dominated during summer notably by anticyclonic conditions allowing the thermal breezes to express themselves. This regime of wind is in the center of the problem of the ozone pollution because it pulls frequently an accumulation of primary and secondary pollutants in the course of days within the same air mass. Although being a weakly industrialized department, the Alpes-Maritimes are victims of a strong period of sunshine which allows primary pollutants emitted mainly by the road traffic to produce some ozone. Through the data of pollution stemming from the network of surveillance of the air quality AtmoPACA as well as from very numerous measures of ground, the objective is to understand better the relations between the spatial and temporal variability of the ozone and that of the weather conditions to various scales. Having detailed the history of the available ozone and nitrogen dioxide measures in the department, the first approach in macro-scale is led between the NCEP reanalysis and the ozone pollution levels in nine measures stations of the Alpes-Maritimes. This first level of analysis allows defining the general meteorological configurations characterizing an episode of pollution by the ozone. The presence of an anticyclonic ridge on the Western Europe associated with weak speeds of wind, weak rates of relative humidity and a weak relative vorticity, provoke a degradation of the air quality in the department. A second analysis level is then approached: it is a question of clarifying in meso-scale and in micro-scale the weather conditions convenient to strong ozone concentrations. For it, itinerant ozone measures campaigns are made in the whole of the department; an important data base is established on Nice and in its

  1. Preliminary comparative study of middle Anisian vertebrate ichnoassociation from South-Eastern Alps

    Science.gov (United States)

    Valdiserri, D.; Todesco, R.; Avanzini, M.

    2009-04-01

    Anisian vertebrate tracks from the south-eastern Alps are known since the first decades of 1900s (Abel, 1926). The sedimentary units yielding footprints are characterized by the alternation of limestone influenced by terrigenous supply with mere marine and volcanic layers allowing a precise dating. In this study, we compare four different ichnoassociations from three different outcrops in the South-Eastern Alps correlating them chronologically and sedimentologically. They were found to be subsequent in time from Lower Pelsonian (Bad Gfrill-Voltago Conglomerate; Todesco, 2007) through middle Pelsonian (Bad Gfrill- Giovo Formation) (Valdiserri et al., 2006) and basal Illyrian (Piz da Peres- Richthofen Conglomerate; Todesco et al., 2008) to the middle Illyrian (Val Duron-Morbiac Limestone; Avanzini et al., 2007). In all these ichno-associations, Rhynchosauroides, an ichno-genus referable to a lizard - like trackmaker well known in the European Anisian, is dominant. Within this group at least four different morphotypes are known, probably reflecting both intraspecific variation (i.e. sexual dimorphism) and different ichnospecies. Although the Chirotheridae group, referred to Archosaurian trackmakers Synaptichnium is represented in both Pelsonian ichnoassociation of the Bad Gfrill outcrop, while Chirotherium , Isochirotherium and Brachichirotherium are recognized both in Pelsonian and in Illyrian ichnosites with a incremental presence in the Illyrian The ichofamiliae Rotodactylidae und Procolophonidae seem well represented in the Pelsonian strata but absent in the Illyrian ones. The preliminarly comparative analysis of these four correlated ichnosites and the comparision with the yet known ones (Avanzini and Mietto 2008) pointed out the expected predominance of the Lepidosaurian-Archosaurian association typical for the middle Triassic ichnofauna. The incremental presence of the Chirotherian track in Illyrian and the presence of the Procolophonichium just in the

  2. Culturable yeasts in meltwaters draining from two glaciers in the Italian Alps

    Science.gov (United States)

    Buzzini, Pietro; Turchetti, Benedetta; Diolaiuti, Guglielmina; D'Agata, Carlo; Martini, Alessandro; Smiraglia, Claudio

    The meltwaters draining from two glaciers in the Italian Alps contain metabolically active yeasts isolable by culture-based laboratory procedures. The average number of culturable yeast cells in the meltwaters was 10 20 colony-forming units (CFU) L-1, whereas supraglacial stream waters originating from overlying glacier ice contained 80% of isolated strains (Cryptococcus spp. and Rhodotorula spp. were 33.3% and 17.8% of total strains, respectively). Culturable yeasts were psychrotolerant, predominantly obligate aerobes and able to degrade organic macromolecules (e.g. starch, esters, lipids, proteins). To the authors' knowledge, this is the first study to report the presence of culturable yeasts in meltwaters originating from glaciers. On the basis of these results, it is reasonable to suppose that the viable yeasts observed in meltwaters derived predominantly from the subglacial zone and that they originated from the subglacial microbial community. Their metabolic abilities could contribute to the microbial activity occurring in subglacial environments.

  3. First-order similarities and differences between Alps, Dinarides, Hellenides and Anatolides-Taurides

    Science.gov (United States)

    Schmid, Stefan M.; Bernoulli, Daniel; Fügenschuh, Bernhard; Matenco, Liviu; Schefer, Senecio; Oberhänsli, Roland; van Hinsbergen, Douwe; Ustaszewski, Kamil

    2013-04-01

    We correlated tectonic units across several circum-Mediterranean orogen strands between the Alps, Carpathians, the Balkan Peninsula, the Aegean and Western Turkey. Our compilation allows discussing fundamental along-strike similarities and differences. One first-order difference is that Dinarides-Hellenides, Anatolides and Taurides represent orogens of opposite subduction polarity and age with respect to the Alps and Carpathians. The internal Dinarides are linked to the Alps and Western Carpathians along the Mid-Hungarian fault zone, a suspected former trench-trench transform fault; its lithospheric root was obliterated during Neogene back-arc extension that formed the Pannonian Basin. Dinarides and Hellenides alike consist of far-travelled nappes detached from the Adriatic continental margin along décollement horizons in Paleozoic or younger stratigraphic levels during Cretaceous and Cenozoic orogeny. The more internal nappes (i.e. Jadar-Kopaonik, Drina-Ivanjica, East Bosnian-Durmitor and their Pelagonian and Almopias equivalents in the Hellenides) are composite nappes whereby the allochthonous Adriatic margin sequences passively carry ophiolites (Western Vardar Ophiolitic Unit) obducted during the latest Jurassic-earliest Cretaceous. These obducted ophiolitic units, as well as ophiolites obducted onto Europe-derived units presently found in the East Carpathians (Eastern Vardar Ophiolitic Unit obducted onto the Dacia continental block), root in one single Neotethys ocean that started closing with the initiation of obduction in the latest Jurassic; final suturing occurred during Cretaceous times, terminating with the formation of the Sava-Izmir-Ankara suture in the latest Cretaceous. Ophiolitic "massifs" found outside the Sava-Izmir-Ankara suture zone do not mark oceanic sutures, nor do the Drina-Ivanjica and Pelagonian "massifs" represent independent continental fragments (terranes). The same logic applies to Western Turkey with the difference that the ophiolites

  4. Around the laboratories: CERN: LEP in the Alps; Putting four LEP experiments together; Heavier ions

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    With CERN's 27-kilometre LEP electron-positron collider shut down for the winter, LEP specialists met in Chamonix in the French Alps from 19-25 January to review the machine's 1991 performance and to look at the ways of improving it. ; Since they started taking data in August 1989, the four big LEP experiments - Aleph, Delphi, L3 and Opal - have been providing precision information about the Z particle, the electrically neutral carrier of the weak nuclear force and at 91 GeV the heavisest elementary particle known.; Work by a major international collaboration is progressing well for a new heavy ion system, capable of providing experiments at CERN with a wide range of heavy ions, extending up to the heaviest elements in the Periodic Table. First beams should be available in 1994

  5. Resonant laser power build-up in ALPS-A 'light shining through a wall' experiment

    International Nuclear Information System (INIS)

    Ehret, Klaus; Frede, Maik; Ghazaryan, Samvel; Hildebrandt, Matthias; Knabbe, Ernst-Axel; Kracht, Dietmar; Lindner, Axel; List, Jenny; Meier, Tobias; Meyer, Niels; Notz, Dieter; Redondo, Javier; Ringwald, Andreas; Wiedemann, Guenter; Willke, Benno

    2009-01-01

    The ALPS Collaboration runs a 'light shining through a wall' (LSW) experiment to search for photon oscillations into 'weakly interacting sub-eV particles' (WISPs) inside of a superconducting HERA dipole magnet at the site of DESY. In this paper we report on the first successful integration of a large-scale optical resonant cavity to boost the available power for WISP production in this type of experiments. The key elements are a frequency tunable narrow line-width continuous wave laser acting as the primary light source and an electronic feed-back control loop to stabilize the power build-up. We describe and characterize our apparatus and demonstrate the data analysis procedures on the basis of a brief exemplary run.

  6. Enercoop Rhone-Alpes: a green and citizen-oriented electricity

    International Nuclear Information System (INIS)

    2010-01-01

    Enercoop is a collective interest cooperative company which aims at providing electricity from renewable sources and at developing renewable energies in France. After a presentation of its objectives and strategies, this document gives an overview of the energy and socio-economic context in Europe and France, recalls the origin of this project and more particularly in the Rhone-Alpes region. It presents its objectives in terms of pricing and citizen empowerment, how to join Enercoop, its guarantees, its philosophy (ethical and democratic), its objectives in terms of renewable energy production, its relationship with ERDF (the company which manages the electricity distribution network in France). After some testimonies, some comments are made about energy management challenges

  7. Intra-continental subduction and contemporaneous lateral extrusion of the upper plate: insights into Alps-Adria interactions

    Science.gov (United States)

    van Gelder, Inge; Willingshofer, Ernst; Sokoutis, Dimitrios; Cloetingh, Sierd

    2017-04-01

    A series of physical analogue experiments were performed to simulate intra-continental subduction contemporaneous with lateral extrusion of the upper plate to study the interferences between these two processes at crustal levels and in the lithospheric mantle. The lithospheric-scale models are specifically designed to represent the collision of the Adriatic microplate with the Eastern Alps, simulated by an intra-continental weak zone to initiate subduction and a weak confined margin perpendicular to the direction of convergence in order to allow for extrusion of the lithosphere. The weak confined margin is the analog for the opening of the Pannonian back-arc basin adjacent to the Eastern Alps with the direction of extension perpendicular to the strike of the orogen. The models show that intra-continental subduction and coeval lateral extrusion of the upper plate are compatible processes. The obtained deformation structures within the extruding region are similar compared to the classical setup where lateral extrusion is provoked by lithosphere-scale indentation. In the models a strong coupling across the subduction boundary allows for the transfer of abundant stresses to the upper plate, leading to laterally varying strain regimes that are characterized by crustal thickening near a confined margin and dominated by lateral displacement of material near a weak lateral confinement. During ongoing convergence the strain regimes propagate laterally, thereby creating an area of overlap characterized by transpression. In models with oblique subduction, with respect to the convergence direction, less deformation of the upper plate is observed and as a consequence the amount of lateral extrusion decreases. Additionally, strain is partitioned along the oblique plate boundary leading to less subduction in expense of right lateral displacement close to the weak lateral confinement. Both oblique and orthogonal subduction models have a strong resemblance to lateral extrusion

  8. FEASIBILITY OF THE AEROSOL-TO-LIQUID PARTICLE EXTRACTION SYSTEM (ALPES) FOR COLLECTION OF VIABLE FRANCISELLA SP.

    Energy Technology Data Exchange (ETDEWEB)

    Heitkamp, M

    2006-08-07

    Several Biowatch monitoring sites in the Houston area have tested positive for Francisella tularensis and there is a need to determine whether natural occurring Francisella-related microorganism(s) may be responsible for these observed positive reactions. The collection, culturing and characterization of Francisella-related natural microorganisms will provide the knowledge base to improve the future selectivity of Biowatch monitoring for Francisella. The aerosol-to-liquid particle extraction system (ALPES) is a high-efficiency, dual mechanism collection system that utilizes a liquid collection medium for capture of airborne microorganisms. Since the viability of microorganisms is preserved better in liquid medium than on air filters, this project was undertaken to determine whether Francisella philomiragia and Francisella tularensis LVS maintain acceptable viability in the continuous liquid recirculation, high direct current voltage and residual ozone concentrations which occur during ALPES operation. Throughout a series of preliminary trial runs with representative gram-negative and gram-positive microorganisms, several design modifications and improvements to the ALPES optimized liquid handling, electrical stability, sampling and overall performance for biological sampling. Initial testing with Francisella philomiragia showed viability was preserved better in PBS buffer than HBSS buffer. Trial runs at starting cell concentrations of 1.8 x 10{sup 6} and 2.5 x 10{sup 4} CFU/L showed less than a 1-log decrease in viability for F. philomiragia after 24 h in the ALPES. Francisella tularensis LVS (live vaccine strain) was used as a surrogate for virulent F. tularensis in ALPES trial runs conducted at starting cell concentrations of 10{sup 4}, 10{sup 5} and 10{sup 6} CFU/L. F. tularensis LVS was slow-growing and required highly selective growth media to prevent overgrowth by collected airborne microorganisms. In addition, one ALPES unit intake was HEPA filtered during

  9. Palaeomagnetic time and space constraints of the Early Cretaceous Rhenodanubian Flysch zone (Eastern Alps)

    Science.gov (United States)

    Dallanave, Edoardo; Kirscher, Uwe; Hauck, Jürgen; Hesse, Reinhard; Bachtadse, Valerian; Wortmann, Ulrich Georg

    2018-06-01

    The Rhenodanubian Flysch zone (RDF) is a Lower Cretaceous-lower Palaeocene turbidite succession extending for ˜500 km from the Danube at Vienna to the Rhine Valley (Eastern Alps). It consists of calcareous and siliciclastic turbidite systems deposited in a trench abyssal plain. The age of deposition has been estimated through micropalaeontologic dating. However, palaeomagnetic studies constraining the age and the palaeolatitude of deposition of the RDF are still missing. Here, we present palaeomagnetic data from the Early Cretaceous Tristel and Rehbreingraben Formations of the RDF from two localities in the Bavarian Alps (Rehbrein Creek and Lainbach Valley, southern Germany), and from the stratigraphic equivalent of the Falknis Nappe (Liechtenstein). The quality of the palaeomagnetic signal has been assessed by either fold test (FT) or reversal test (RT). Sediments from the Falknis Nappe are characterized by a pervasive syntectonic magnetic overprint as tested by negative FT, and are thus excluded from the study. The sediments of the Rehbreingraben Formation at Rehbrein Creek, with positive RT, straddle magnetic polarity Chron M0r and the younger M΄-1r΄ reverse event, with an age of ˜127-123 Ma (late Barremian-early Aptian). At Lainbach Valley, no polarity reversals have been observed, but a positive FT gives confidence on the reliability of the data. The primary palaeomagnetic directions, after correction for inclination shallowing, allow to precisely constrain the depositional palaeolatitude of the Tristel and Rehbreingraben Formations around ˜28°N. In a palaeogeographic reconstruction of the Alpine Tethys at the Barremian/Aptian boundary, the RDF is located on the western margin of the Briançonnais terrain, which was separated from the European continent by the narrow Valais Ocean.

  10. Gold mineralisation near the Main Divide, upper Wilberforce valley, Southern Alps, New Zealand

    International Nuclear Information System (INIS)

    Becker, J.A.; Craw, D.; Horton, T.; Chamberlain, C.P.

    2000-01-01

    Veins up to 8 m wide fill extensional fractures in Torlesse Terrane metasediments near the Main Divide in the upper Wilberforce valley, Canterbury, New Zealand. The upper Wilberforce veins are part of a prominent 40 km long, NNE-trending swarm of gold-bearing veins formed across the Main Divide during the Late Cenozoic rise of the Southern Alps. The veins occur within, and near, a prominent set of faults which constitute the Main Divide Fault Zone. The veins are irregular in shape due to contrasting host rock properties, and have been only weakly sheared and deformed. Veins cut across greywacke beds and follow irregularly along argillite beds, on the 1-10 m scale. Quartz dominates vein mineralogy, but albite forms up to 45% of some veins, and minor chlorite, pyrite, arsenopyrite, chalcopyrite, and gold occur sporadically, especially in breccias near vein margins. Fluid inclusions in vein quartz homogenise at 180-253 degrees C, and arsenopyrite composition (28.3-30.8 at.% As) suggest formation temperatures of 250-350 degrees C. Elevated arsenic levels (up to 200 ppm above a background of 10 ppm) in some host greywackes and argellites suggest that hydrothermal activity pervaded host rocks as well as forming veins, but there is no textural evidence for this fluid flow. Late-stage carbonates in faults adjacent to the quartz veins, but which postdate the quartz veins, have δ 18 O ranging from 11.1 to 25.6 per thousand, and δ 13 C ranging from -12.5 to -1.1 per thousand. These carbonates were deposited by a mixture of meteoric and crustally isotopically exchanged fluid as a shallow-level manifestation of the same hydrothermal system which deposited the quartz veins. The upper Wilberforce veins structurally and mineralogically resemble some Late Cenozoic gold-bearing vein systems in the Mt Cook area, 100 km to the southwest along the Southern Alps. (author). 52 refs., 9 figs., 3 tabs

  11. From après-ski to après-tourism: the Alps in transition?

    Directory of Open Access Journals (Sweden)

    Philippe Bourdeau

    2009-12-01

    Full Text Available Winter sports occupy a prominent place in European tourism, not only because of their economic importance in mountainous areas but also due to their major symbolic significance in the "leisure civilisation". Yet the world of winter tourism is full of uncertainties connected with climate change and also with evolutions and structural breaks that call into question the development model on which it is based. This context of profound change gives us the opportunity to question the limits of the industrial model that has governed the development of the Alps for the practice of skiing and to examine alternative future scenarios to "all-out skiing" and even "all-out tourism".Les sports d’hiver occupent une place de premier plan dans le tourisme européen, non seulement du fait de leur poids économique dans les régions de montagne, mais aussi par leur forte dimension symbolique dans la « civilisation des loisirs ». Pourtant l’univers du tourisme hivernal est parcouru par de nombreuses incertitudes liées au changement climatique, mais aussi à des évolutions et des ruptures structurelles qui remettent en question le modèle de développement sur lequel il repose. Ce contexte de mutation permet d’interroger les limites du modèle industriel qui a présidé à l’aménagement des Alpes pour la pratique du ski et d’examiner des figures d’avenir alternatives au « tout ski » et même au « tout tourisme ».

  12. Assessing the Sensitivity of Mountain Forests to Site Degradation in the Northern Limestone Alps, Europe

    Directory of Open Access Journals (Sweden)

    Birgit Reger

    2015-05-01

    Full Text Available Because of some land-use practices (such as overstocking with wild ungulates, historical clear-cuts for mining, and locally persisting forest pasture, protective forests in the montane vegetation belt of the Northern Limestone Alps are now frequently overaged and poorly structured over large areas. Windthrow and bark beetle infestations have generated disturbance areas in which forests have lost their protective functions. Where unfavorable site conditions hamper regeneration for decades, severe soil loss may ensue. To help prioritize management interventions, we developed a geographic information system-based model for assessing sensitivity to site degradation and applied it to 4 test areas in the Northern Limestone Alps of Austria and Bavaria. The model consists of (1 analysis of site conditions and forest stand structures that could increase sensitivity to degradation, (2 evaluation of the sensitivity of sites and stands, and (3 evaluation and mapping of mountain forests' sensitivity to degradation. Site conditions were modeled using regression algorithms with data on site parameters from pointwise soil and vegetation surveys as responses and areawide geodata on climate, relief, and substrate as predictors. The resulting predictor–response relationships were applied to test areas. Stand structure was detected from airborne laser scanning data. Site and stand parameters were evaluated according to their sensitivity to site degradation. Sensitivities of sites and stands were summarized in intermediate-scale sensitivity maps. High sensitivity was identified in 3 test areas with pure limestone and dolomite as the prevailing sensitivity level. Moderately sensitive forests dominate in the final test area, Grünstein, where the bedrock in some strata contains larger amounts of siliceous components (marl, mudstone, and moraines; degraded and slightly sensitive forests were rare or nonexistent in all 4 test areas. Providing a comprehensive overview

  13. Conservation of brown bear in the Alps: space use and settlement behavior of reintroduced bears

    Science.gov (United States)

    Preatoni, Damiano; Mustoni, Andrea; Martinoli, Adriano; Carlini, Eugenio; Chiarenzi, Barbara; Chiozzini, Simonetta; Van Dongen, Stefan; Wauters, Luc A.; Tosi, Guido

    2005-11-01

    Large carnivores typically need large home ranges containing habitats patches of different quality. Consequently, their conservation requires habitat protection and management at the landscape scale. In some cases, reintroduction might be used to support remnant or restore extinct populations. This is the case for the brown bear ( Ursus arctos) in the Italian Alps. We monitored spacing behavior and settlement of reintroduced brown bears in Adamello-Brenta Natural Park, North-Italy, using radio-tracking. Habitat use, dispersion and survival were studied to evaluate the success of reintroduction and possible conflicts with man. All three males and five of seven females settled in the study area. Most bears roamed widely the first months after release, exploring the new habitat. Patterns of home range overlap between seasons and years revealed that home range use stabilized the year after first hibernation. Home ranges were larger in the mating season (May-July) than in spring or autumn. Home ranges varied between 34 and 1813 km 2 the year after release, but core-areas, where feeding activity was concentrated, were much smaller. Some bears had exclusive core-areas in summer and autumn, but most showed considerable core-area overlap with animals of the same and/or the opposite sex. Bears selected deciduous forests, mixed and conifer forests were used according to availability, and areas with anthropogenic disturbance were avoided. Most bears settled and some reproduced successfully at the release site, causing high initial population growth, suggesting that reintroduction can help to re-establish a brown bear population in the Italian Alps.

  14. Noninvasive molecular tracking of colonizing wolf (Canis lupus) packs in the western Italian Alps.

    Science.gov (United States)

    Lucchini, V; Fabbri, E; Marucco, F; Ricci, S; Boitani, L; Randi, E

    2002-05-01

    We used noninvasive methods to obtain genetic and demographic data on the wolf packs (Canis lupus), which are now recolonizing the Alps, a century after their eradication. DNA samples, extracted from presumed wolf scats collected in the western Italian Alps (Piemonte), were genotyped to determine species and sex by sequencing parts of the mitochondrial DNA (mtDNA) control-region and ZFX/ZFY genes. Individual genotypes were identified by multilocus microsatellite analyses using a multiple tubes polymerase chain reaction (PCR). The performance of the laboratory protocols was affected by the age of samples. The quality of excremental DNA extracts was higher in samples freshly collected on snow in winter than in samples that were older or collected during summer. Preliminary mtDNA screening of all samples allowed species identification and was a good predictor of further PCR performances. Wolf, and not prey, DNA targets were preferentially amplified. Allelic dropout occurred more frequently than false alleles, but the probability of false homozygote determinations was always wolf genotypes, also whether related, with a probability of identity of < 0.015. Genealogical relationships among individuals could be determined reliably if the number of candidate parents was 6-8, and most of them had been sampled and correctly genotyped. Genetic data indicate that colonizing Alpine wolves originate exclusively from the Italian source population and retain a high proportion of its genetic diversity. Spatial and temporal locations of individual genotypes, and kinship analyses, suggest that two distinct packs of closely related wolves, plus some unrelated individuals, ranged in the study areas. This is in agreement with field observations.

  15. Historical glacier outlines from digitized topographic maps of the Swiss Alps

    Science.gov (United States)

    Freudiger, Daphné; Mennekes, David; Seibert, Jan; Weiler, Markus

    2018-04-01

    Since the end of the Little Ice Age around 1850, the total glacier area of the central European Alps has considerably decreased. In order to understand the changes in glacier coverage at various scales and to model past and future streamflow accurately, long-term and large-scale datasets of glacier outlines are needed. To fill the gap between the morphologically reconstructed glacier outlines from the moraine extent corresponding to the time period around 1850 and the first complete dataset of glacier areas in the Swiss Alps from aerial photographs in 1973, glacier areas from 80 sheets of a historical topographic map (the Siegfried map) were manually digitized for the publication years 1878-1918 (further called first period, with most sheets being published around 1900) and 1917-1944 (further called second period, with most sheets being published around 1935). The accuracy of the digitized glacier areas was then assessed through a two-step validation process: the data were (1) visually and (2) quantitatively compared to glacier area datasets of the years 1850, 1973, 2003, and 2010, which were derived from different sources, at the large scale, basin scale, and locally. The validation showed that at least 70 % of the digitized glaciers were comparable to the outlines from the other datasets and were therefore plausible. Furthermore, the inaccuracy of the manual digitization was found to be less than 5 %. The presented datasets of glacier outlines for the first and second periods are a valuable source of information for long-term glacier mass balance or hydrological modelling in glacierized basins. The uncertainty of the historical topographic maps should be considered during the interpretation of the results. The datasets can be downloaded from the FreiDok plus data repository (https://freidok.uni-freiburg.de/data/15008" target="_blank">https://freidok.uni-freiburg.de/data/15008, https://doi.org/10.6094/UNIFR/15008" target="_blank">https://doi.org/10.6094/UNIFR

  16. Deformation of ``Villafranchian'' lacustrine sediments in the Chisone Valley (Western Alps, Italy)

    Science.gov (United States)

    Collo, Giovanni; Giardino, Marco

    1997-09-01

    The Chisone Valley is located in the internal NW Alps, in the Pinerolese District, an area characterized by present low to medium seismicity. Fine-grained sediments (sand, silt and clay with interbedded gravel) crop out in the lower Chisone Valley: they were first interpreted as glaciolacustrine deposits, and then as a lacustrine infilling of the valley floor probably due to differential uplifting of the valley mouth. Review of this data, together with new field and palynological observations, lead us to refer the lacustrine deposits to approximately the Lower Pleistocene (Villafranchian). In many outcrops, the lacustrine deposits show strong soft-sediment deformation such as convolute laminations, water-escape structures and disrupted beds, some of them associated with folds and faults (cm to dm in size); only two sites show metric to decametric folds and faults trending E-W and N-S. Detailed structural analysis conducted along a recently exposed section (Rio Gran Dubbione site) shows several soft-sediment deformation features on the limbs of mesoscale folds. Because of their intimate structural association, the origin of these minor structures seems to be connected to synsedimentary activity on reverse and normal faults (m to dm in size) affecting the lacustrine deposits in the same locality. Soft-sediment deformation features can be interpreted as possible paleoseismites. If so, the present seismicity of the Pinerolese District, which is the major area of such activity in NW Italy, cannot be considered an isolated episode in the geological evolution of the region; even if there is no supporting evidence for continuous seismicity, the deformations in the lacustrine sediments of the Chisone Valley testify to Early Pleistocene seismic activity, probably related to the recent tectonic evolution of the internal side of the NW Alps.

  17. Epidemiology of Pestivirus infection in wild ungulates of the French South Alps.

    Science.gov (United States)

    Martin, Claire; Letellier, Carine; Caij, Brigitte; Gauthier, Dominique; Jean, Nicolas; Shaffii, Anahita; Saegerman, Claude

    2011-01-27

    Inter-species transmission is often incriminated in the epidemiology of Pestivirus diseases. The purpose of this study was to investigate the prevalence of Pestivirus in some mountain wild ungulates and to determine their role in Pestivirus transmission, as mountain pastures are a place where cohabitations between wild and domestic ungulates are particularly high. Between 2003 and 2007, a longitudinal epidemiological study was carried out on hunted ungulates in the French Hautes-Alpes department. Pestivirus-specific antibodies against p80 protein (also named NS3) common to all Bovine Viral Diarrhea Virus (BVDV) and Border Disease Virus (BDV) were found in 45.9% (95% confidence interval [CI95%]: 40.5-51.3%) of the 343 tested chamois (Rupicapra rupicapra). In addition, mouflons (Ovis gmelinii musimon) were shown for the first time to be strongly infected (61.1%; CI95%: 38.6-83.6) by a Pestivirus. These serological ELISA results were confirmed by comparative virus neutralization tests, performed on seven Pestivirus strains by using 15 seropositive samples. The highest antibody titers were directed against 2 BDV strains (Av and 33s strains), rather than BDV-4, a strain responsible for Pyrenean-chamois epizooties. Virus neutralization tests confirm a BDV circulation in wild ungulates in the French South Alps. However, no Pestivirus RNA was detected by reverse-transcriptase polymerase chain reaction in serum and spleen samples from seronegative animals and no virus was isolated from those samples either. Efforts should be made to improve the protocol in order to be able to isolate and characterize the local strain. Finally, the oldness (age) and femaleness (gender) increase the risk of seroconversion in chamois. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. Pestiviruses infections at the wild and domestic ruminants interface in the French Southern Alps.

    Science.gov (United States)

    Martin, Claire; Duquesne, Véronique; Adam, Gilbert; Belleau, Eric; Gauthier, Dominique; Champion, Jean-Luc; Saegerman, Claude; Thiéry, Richard; Dubois, Eric

    2015-02-25

    In alpine pasture, interspecies transmission has recently been incriminated in the epidemiology of pestivirus infection. The aim of this study was to investigate pestivirus infections in wild and domestic ruminants sharing pastures in the French Southern Alps. Animal sera were screened for pestivirus antibodies against the pestivirus NS3 protein by a commercial blocking enzyme linked immunosorbent assay (ELISA). All 38 domestic herds tested were positive for pestivirus-specific antibodies. Individual sero-prevalence reached 76.5% (95% confidence interval [95% CI]: [74.2-78.8%]) of the 1383 sheep tested. For wild ruminants, 38.7% (95% CI: [33.8-43.9%]) of the 369 chamois tested, 28.7% (95% CI: [17.4-38.1%]) of the 72 roe deer, and 22.2% (95% CI: [6.5-37.9%]) of the 27 mouflons were seropositive. Virus screening was carried out on spleen samples from hunted wild animals (n=160) and from 15 domestic ruminants (clinically suspected to be persistently infected animals), by a conventional reverse transcription-polymerase chain reaction (RT-PCR). Three pestivirus strains were isolated from the sheep samples positive by RT-PCR. The viruses were classified in the BDV-3, BDV-Tunisian and BDV-6 genotypes. For the first time, one strain (RUPI-05 strain) was isolated from an alpine chamois and clustered in the BDV-6 genotype, showing in the 5'-UTR region 92% of identity with the ovine isolate from the same area. Thus, an active circulation of pestiviruses was demonstrated in both wild and domestic ungulates from the French Southern Alps. The results suggest that interspecies transmission between sheep and chamois probably occur. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. The interplay between subduction and lateral extrusion: A case study for the European Eastern Alps based on analogue models

    Science.gov (United States)

    van Gelder, I. E.; Willingshofer, E.; Sokoutis, D.; Cloetingh, S. A. P. L.

    2017-08-01

    A series of analogue experiments simulating intra-continental subduction contemporaneous with lateral extrusion of the upper plate are performed to study the interference between these two processes at crustal levels and in the lithospheric mantle. The models demonstrate that intra-continental subduction and coeval lateral extrusion of the upper plate are compatible processes leading to similar deformation structures within the extruding region as compared to the classical setup, lithosphere-scale indentation. Strong coupling across the subduction boundary allows for the transfer of stresses to the upper plate, where strain regimes are characterized by crustal thickening near a confined margin and dominated by lateral displacement of material near a weak lateral confinement. The strain regimes propagate laterally during ongoing convergence creating an area of overlap characterized by transpression. When subduction is oblique to the convergence direction, the upper plate is less deformed and as a consequence the amount of lateral extrusion decreases. In addition, strain is partitioned along the oblique plate boundary resulting in less subduction in expense of right lateral displacement close to the weak lateral confinement. Both oblique and orthogonal subduction models have a strong resemblance to lateral extrusion tectonics of the Eastern Alps (Europe), where subduction of the adjacent Adriatic plate beneath the Eastern Alps is debated. Our results imply that subduction of Adria is a valid mechanisms to induce extrusion-type deformation within the Eastern Alps lithosphere. Furthermore, our findings suggest that the Oligocene to Late Miocene structural evolution of the Eastern Alps reflects a phase of oblique subduction followed by a later stage of orthogonal subduction conform a Miocene shift in the plate motion of Adria. Oblique subduction also provides a viable mechanism to explain the rapid decrease in slab length of the Adriatic plate beneath the Eastern Alps

  20. Powered mobility intervention: understanding the position of tool use learning as part of implementing the ALP tool.

    Science.gov (United States)

    Nilsson, Lisbeth; Durkin, Josephine

    2017-10-01

    To explore the knowledge necessary for adoption and implementation of the Assessment of Learning Powered mobility use (ALP) tool in different practice settings for both adults and children. To consult with a diverse population of professionals working with adults and children, in different countries and various settings; who were learning about or using the ALP tool, as part of exploring and implementing research findings. Classical grounded theory with a rigorous comparative analysis of data from informants together with reflections on our own rich experiences of powered mobility practice and comparisons with the literature. A core category learning tool use and a new theory of cognizing tool use, with its interdependent properties: motivation, confidence, permissiveness, attentiveness and co-construction has emerged which explains in greater depth what enables the application of the ALP tool. The scientific knowledge base on tool use learning and the new theory conveys the information necessary for practitioner's cognizing how to apply the learning approach of the ALP tool in order to enable tool use learning through powered mobility practice as a therapeutic intervention in its own right. This opens up the possibility for more children and adults to have access to learning through powered mobility practice. Implications for rehabilitation Tool use learning through powered mobility practice is a therapeutic intervention in its own right. Powered mobility practice can be used as a rehabilitation tool with individuals who may not need to become powered wheelchair users. Motivation, confidence, permissiveness, attentiveness and co-construction are key properties for enabling the application of the learning approach of the ALP tool. Labelling and the use of language, together with honing observational skills through viewing video footage, are key to developing successful learning partnerships.

  1. From the Western Alps across Central Europe: Postglacial recolonisation of the tufa stream specialist Rhyacophila pubescens (Insecta, Trichoptera

    Directory of Open Access Journals (Sweden)

    Haase Peter

    2011-05-01

    Full Text Available Abstract Background Dispersal rates, i.e. the effective number of dispersing individuals per unit time, are the product of dispersal capacity, i.e. a species physiological potential for dispersal, dispersal behaviour, i.e. the decision to leave a habitat patch in favour of another, and connectivity of occupied habitat. Thus, dispersal of species that are highly specialised to a certain habitat is limited by habitat availability. Species inhabiting very stable environments may also adopt a sedentary life-style. Both factors should lead to strong genetic differentiation in highly specialised species inhabiting stable environments. These two factors apply to our model species Rhyacophila pubescens a highly specialised freshwater insect that occurs in tufa springs, a very stable habitat. Results We examined the genetic population structure and phylogeography using range-wide mtCOI sequence and AFLP data from 333 individuals of R. pubescens. We inferred the location of Pleistocene refugia and postglacial colonisation routes of R. pubescens, and examined ongoing local differentiation. Our results indicate intraregional differentiation with a high number of locally endemic haplotypes, that we attributed to habitat specificity and low dispersal rates of R. pubescens. We observed high levels of genetic diversity south of the Alps and genetic impoverishment north of the Alps. Estimates of migrants placed the refugium and the source of the colonisation in the Dauphiné Alps (SW Alps. Conclusions This is the first example of an aquatic insect with a colonisation route along the western margin of the Alps to the Central European highlands. The study also shows that specialisation to a stable environment may have promoted a behavioural shift to decreased dispersal rates, leading to stronger local population differentiation than in less specialised aquatic insects. Alternatively, the occurrence of highly specialised tufa spring habitats may have been more

  2. Clinicopathological categorization of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications.

    Science.gov (United States)

    Paik, Jin Ho; Choe, Ji-Young; Kim, Hyojin; Lee, Jeong-Ok; Kang, Hyoung Jin; Shin, Hee Young; Lee, Dong Soon; Heo, Dae Seog; Kim, Chul-Woo; Cho, Kwang-Hyun; Kim, Tae Min; Jeon, Yoon Kyung

    2017-01-01

    Epstein-Barr virus-positive T/NK-cell lymphoproliferative diseases (EBV-T/NK-LPDs) include several overlapping EBV-related conditions with variably aggressive courses. For prognostic categorization, we retrospectively analyzed 42 EBV-T/NK-LPD cases. Male (79% [33/42]), young (≤40 years; 83% [35/42]) patients and T-cell lineage (81% [34/42]; CD8/CD4 = 1.8) were predominant. Clinicopathologically, three systemic and one cutaneous category were developed: hemophagocytic lymphohistiocytosis (HLH; 26% [11/42]), chronic active EBV infection (CAEBV; 31% [13/42]), systemic unclassifiable disease (24% [10/42]), and hydroa vacciniforme/hydroa vacciniforme-like lymphoma (HV/HVL; 19% [8/42]). Prognostically, cutaneous disease (HV/HVL) was better than systemic disease (p = 0.014; median, 285 vs. 10 months). In systemic diseases, HLH was worst (p = 0.002; 3[HLH] vs. 4[unclassifiable] vs. not reached [CAEBV]). Univariate survival analysis (n = 42) revealed cytopenia (≥one lineage; p 40 years; p = 0.001), T-cell lineage (p = 0.041), hemophagocytic histiocytes (p = 0.031), elevated lactate dehydrogenase (p = 0.020), and liver dysfunction (p = 0.023) predicted shorter survival. In multivariate analysis, T-cell lineage (p = 0.025 [HR =11.3]) and cytopenia (p = 0.028 [HR =5.4]) were independent prognostic factors. Therefore, EBV-T/NK-LPD could be classified into four prognostic categories.

  3. Construction of a YAC contig and STS map spanning 2.5 Mbp in Xq25, the critical region for the X-linked lymphoproliferative (XLP) gene

    Energy Technology Data Exchange (ETDEWEB)

    Lanyi, A.; Li, B.F.; Li, S. [Univ. of Nebraska Medical Center, Omaha, NE (United States)] [and others

    1994-09-01

    X-linked lymphoproliferative disease (XLP) is characterized by a marked vulnerability in Epstein-Barr virus (EBV) infection. Infection of XLP patients with EBV invariably results in fatal mononucleosis, agammaglobulinemia or B-cell lymphoma. The XLP gene lies within a 10 cM region in Xq25 between DXS42 and DXS10. Initial chromosome studies revealed an interstitial, cytogenetically visible deletion in Xq25 in one XLP family (43-004). We estimated the size of the Xq25 deletion by dual laser flow karyotyping to involve 2% of the X chromosome, or approximately 3 Mbp of DNA sequences. To further delineate the deletion we performed a series of pulsed field gel electrophoresis (PFGE) analyses which showed that DXS6 and DXS100, two Xq25-specific markers, are missing from 45-004 DNA. Five yeast artificial chromosomes (YACs) from a chromosome X specific YAC library containing sequences deleted in patient`s 43-004 DNA were isolated. These five YACs did not overlap, and their end fragments were used to screen the CEPH MegaYAC library. Seven YACs were isolated from the CEPH MegaYAC library. They could be arranged into a contig which spans between DXS6 and DXS100. The contig contains a minimum of 2.5 Mbp of human DNA. A total of 12 YAC end clone, lambda subclones and STS probes have been used to order clones within the contig. These reagents were also used in Southern blot and patients showed interstitial deletions in Xq25. The size of these deletions range between 0.5 and 2.5 Mbp. The shortest deletion probably represents the critical region for the XLP gene.

  4. Primary tacrolimus (FK506) therapy and the long-term risk of post-transplant lymphoproliferative disease in pediatric liver transplant recipients.

    Science.gov (United States)

    Cacciarelli, T V; Reyes, J; Jaffe, R; Mazariegos, G V; Jain, A; Fung, J J; Green, M

    2001-10-01

    While the overall incidence of post-transplant lymphoproliferative disease (PTLD) in pediatric liver transplant recipients has been reported to be 4-11%, the long-term risk of PTLD associated with primary tacrolimus therapy is unknown. Therefore, in order to determine the incidence and long-term risk of PTLD, the present study examined 131 pediatric recipients who underwent liver transplantation (LTx) between October 1989 and December 1991 and received primary tacrolimus therapy. This cohort of children was evaluated over an extended time-period (until December 31 1996) with a mean follow-up of 6.3 yr. Actuarial Kaplan-Meier analysis was utilized to determine the risk of PTLD over time. The overall incidence of PTLD was 13% (17/131) with an average age of 4.3 +/- 0.75 yr at diagnosis. Pretransplant Epstein-Barr virus (EBV) serologies were negative in 82%, positive in 12%, and not available in 6% of the patients. The median time to diagnosis of PTLD post-Tx was 11.9 months (mean 16.4 +/- 3.9, range 1.7-63.0 months). Mean tacrolimus dose and plasma trough level (as evaluated by enzyme-linked immunosorbent assay [ELISA]) at the time of diagnosis was 0.32 +/- 0.06 mg/kg/day and 1.3 +/- 0.3 ng/mL, respectively. The cumulative long-term risk of PTLD was found to increase over time: 3% at 6 months, 8% at 1 yr, 12% at 2 yr, 14% at 3 yr, and 15% at 4 and 5 yr. Mortality from PTLD was 12% (two of 17 patients). Primary tacrolimus use in pediatric LTx has a long-term risk of PTLD approaching 15%, with the majority of episodes (78%) occurring in the first 2 yr, suggesting that intense EBV surveillance should occur early post-transplantation.

  5. Schnitzler Syndrome With Delirium and Vertigo: The Utility of Neurologic Manifestations in Diagnosis.

    Science.gov (United States)

    Tolkachjov, Stanislav N; Wetter, David A

    2017-06-01

    Schnitzler syndrome (SS) is an autoinflammatory dermatosis that often goes undiagnosed for 5-6 years. Patients typically carry a diagnosis of urticaria; however, their cutaneous symptoms fail to respond to typical urticaria therapies and lack symptoms such as pruritus. Additionally, patients with SS may see multiple providers for nonspecific complaints of fever, lymphadenopathy, arthralgias, and bone pain. A correct diagnosis is paramount, as close to 20% of patients may develop a lymphoproliferative disorder and appropriate treatment may ameliorate all symptoms.1 We report 2 cases of SS misdiagnosed as urticaria for years in order to illuminate diagnostic pearls, histopathological findings, and treatment modalities. Additionally, we highlight the importance of neurologic disturbances in this rare but important differential diagnosis of urticaria. J Drugs Dermatol. 2017;16(6):625-627..

  6. A Case Report of NK-Cell Lymphoproliferative Disease With a Wide Involvement of Digestive Tract Develop Into Epstein-Barr Virus Associated NK/T Cell Lymphoma in an Immunocompetent Patient.

    Science.gov (United States)

    Chen, Haotian; Zhang, Yu; Jiang, Zhinong; Zhou, Wei; Cao, Qian

    2016-03-01

    Epstein-Barr virus (EBV) plays an important role in various diseases. EBV-associated lymphoproliferative disease (LPD) is a rare disease with a canceration tendency. It is difficult to differentiate LPD with involvement of digestive tract from Crohn disease due to similar clinical and endoscopic manifestations. We present a case report of multiple ulcers with esophagus, small bowel and the entire colon involved, proved to be NK-Cell LPD, developed into EBV-associated NK/T Cell lymphoma, in an immunocompetent man who was initially misdiagnosed as Crohn disease.This report underscores that intestinal ulcers should be cautiously diagnosed, for it sometimes could be a precancerous lesion.

  7. An Animal Model for Human EBV-Associated Hemophagocytic Syndrome

    Science.gov (United States)

    Hayashi, Kazuhiko; Ohara, Nobuya; Teramoto, Norihiro; Onoda, Sachiyo; Chen, Hong-Li; Oka, Takashi; Kondo, Eisaku; Yoshino, Tadashi; Takahashi, Kiyoshi; Yates, John; Akagi, Tadaatsu

    2001-01-01

    Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS) is often associated with fatal infectious mononucleosis. However, the animal model for EBV-AHS has not been developed. We reported the first animal model for EBV-AHS using rabbits infected with EBV-related herpesvirus of baboon (HVP). Eleven of 13 (85%) rabbits inoculated intravenously with HVP-producing cells developed fatal lymphoproliferative disorders (LPD) between 22 and 105 days after inoculation. LPD was also accompanied by hemophagocytic syndrome (HPS) in nine of these 11 rabbits. The peroral spray of cell-free HVP induced the virus infection with increased anti-EBV-viral capsid antigen-IgG titers in three of five rabbits, and two of these three infected rabbits died of LPD with HPS. Autopsy revealed hepatosplenomegaly and swollen lymph nodes. Atypical lymphoid T cells expressing EBV-encoded small RNA-1 infiltrated diffusely in many organs, frequently involving the lymph nodes, spleen, and liver. Hemophagocytic histiocytosis was observed in the lymph nodes, spleen, bone marrow, and thymus. HVP-DNA was detected in the tissues and peripheral blood from the infected rabbits by polymerase chain reaction or Southern blot analysis. Reverse transcriptase-polymerase chain reaction revealed both HVP-EBNA1 and HVP-EBNA2 transcripts, suggesting latency type III infection. These data indicate that the high rate of rabbit LPD with HPS induction is caused by HVP. This system is useful for studying the pathogenesis, prevention, and treatment of human EBV-AHS. PMID:11290571

  8. Synthesis and effect of Ce and Mn co-doping on photoluminescence characteristics of Ca6AlP5O20:Eu novel phosphors.

    Science.gov (United States)

    Shinde, K N; Dhoble, S J

    2013-01-01

    A series of Ca6AlP5O20 doped with rare earths (Eu and Ce) and co-doped (Eu, Ce and Eu,Mn) were prepared by combustion synthesis. Under Hg-free excitation, Ca6AlP5O20:Eu exhibited Eu(2+) (486 nm) emission in the blue region of the spectrum and under near Hg excitation (245 nm), Ca6AlP5O20:Ce phosphor exhibited Ce(3+) emission (357 nm) in the UV range. Photoluminescence (PL) peak intensity increased in Ca6AlP5O20:Eu,Ce and Ca6AlP5O20:Eu, Mn phosphors due to co-activators of Ce(3+) and Mn(2+) ions. As a result, these ions played an important role in PL emission in the present matrix. Ca6AlP5O20:Eu, Ce and Ca6AlP5O20:Eu, Mn phosphors provided energy transfer mechanisms via Ce(3+) → Eu(2+) and Eu(2+) → Mn(2+), respectively. Eu ions acted as activators and Ce ions acted as sensitizers. Ce emission energy was well matched with Eu excitation energy in the case of Ca6AlP5O20:Eu, Ce and Eu ions acted as activators and Mn ions acted as sensitizers in Ca6AlP5O20:Eu, Mn. This study included synthesis of new and efficient phosphate phosphors. The impact of doping and co-doping on photoluminescence properties and energy transfer mechanisms were investigated and we propose a feasible interpretation. Copyright © 2012 John Wiley & Sons, Ltd.

  9. Urofacial syndrome

    Directory of Open Access Journals (Sweden)

    Kamal F Akl

    2012-01-01

    Full Text Available The urofacial syndrome is characterized by functional obstructive uropathy asso-ciated with an inverted smile. The importance of the subject is that it sheds light, not only on the muscles of facial expression, but also on the inheritance of voiding disorders and lower urinary tract malformations. We report a 10-year-old-male patient who had the urofacial syndrome. Early diagnosis of the urofacial syndrome is important to avoid upper urinary tract damage and renal failure.

  10. Refeeding syndrome

    OpenAIRE

    Tripathy, Swagata; Mishra, Padmini; Dash, S. C.

    2008-01-01

    Refeeding syndrome is a potentially fatal medical condition that may affect malnourished patients in response to an inappropriately rapid overfeeding. This commonly occurs following the institution of nutritional support, especially parenteral or enteral nutrition. The most characteristic pathophysiology of refeeding syndrome relates to the rapid consumption of phosphate after glucose intake and subsequent hypophosphatemia. Refeeding syndrome can manifest as either metabolic changes (hypokala...

  11. Revesz syndrome

    Directory of Open Access Journals (Sweden)

    Dayane Cristine Issaho

    2015-04-01

    Full Text Available Revesz syndrome is a rare variant of dyskeratosis congenita and is characterized by bilateral exudative retinopathy, alterations in the anterior ocular segment, intrauterine growth retardation, fine sparse hair, reticulate skin pigmentation, bone marrow failure, cerebral calcification, cerebellar hypoplasia and psychomotor retardation. Few patients with this syndrome have been reported, and significant clinical variations exist among patients. This report describes the first Brazilian case of Revesz syndrome and its ocular and clinical features.

  12. Reye's Syndrome

    Science.gov (United States)

    ... that contain aspirin. Some hospitals and medical facilities conduct newborn screenings for fatty acid oxidation disorders to determine which children are at greater risk of developing Reye's syndrome. ...

  13. Marfan Syndrome (For Teens)

    Science.gov (United States)

    ... genetic disorder called Marfan syndrome. What Is Marfan Syndrome? Marfan syndrome is named after Antoine Marfan, the French ... immediately. What's Life Like for Teens With Marfan Syndrome? Marfan syndrome affects people differently, so life is not ...

  14. Learning about Marfan Syndrome

    Science.gov (United States)

    ... Additional Resources for Marfan Syndrome What is Marfan syndrome? Marfan syndrome is one of the most common inherited ... FAQ Top of page Additional Resources For Marfan Syndrome Marfan syndrome [nlm.nih.gov] From Medline Plus Marfan ...

  15. Russell-Silver syndrome

    Science.gov (United States)

    Silver-Russell syndrome; Silver syndrome; RSS; Russell-Silver syndrome ... One in 10 children with this syndrome has a problem involving chromosome 7. In other people with the syndrome, it may affect chromosome 11. Most of the time, it ...

  16. What Is Usher Syndrome?

    Science.gov (United States)

    ... Action You are here Home › Retinal Diseases Listen Usher Syndrome What is Usher syndrome? How is Usher syndrome ... available? Are there any related diseases? What is Usher Syndrome? Usher syndrome is an inherited condition characterized by ...

  17. Shear wave velocities in the upper mantle of the Western Alps: new constraints using array analysis of seismic surface waves

    Science.gov (United States)

    Lyu, Chao; Pedersen, Helle A.; Paul, Anne; Zhao, Liang; Solarino, Stefano

    2017-07-01

    It remains challenging to obtain absolute shear wave velocities of heterogeneities of small lateral extension in the uppermost mantle. This study presents a cross-section of Vs across the strongly heterogeneous 3-D structure of the western European Alps, based on array analysis of data from 92 broad-band seismic stations from the CIFALPS experiment and from permanent networks in France and Italy. Half of the stations were located along a dense sublinear array. Using a combination of these stations and off-profile stations, fundamental-mode Rayleigh wave dispersion curves were calculated using a combined frequency-time beamforming approach. We calculated dispersion curves for seven arrays of approximately 100 km aperture and 14 arrays of approximately 50 km aperture, the latter with the aim of obtaining a 2-D vertical cross-section of Vs beneath the western Alps. The dispersion curves were inverted for Vs(z), with crustal interfaces imposed from a previous receiver function study. The array approach proved feasible, as Vs(z) from independent arrays vary smoothly across the profile length. Results from the seven large arrays show that the shear velocity of the upper mantle beneath the European plate is overall low compared to AK135 with the lowest velocities in the internal part of the western Alps, and higher velocities east of the Alps beneath the Po plain. The 2-D Vs model is coherent with (i) a ∼100 km thick eastward-dipping European lithosphere west of the Alps, (ii) very high velocities beneath the Po plain, coherent with the presence of the Alpine (European) slab and (iii) a narrow low-velocity anomaly beneath the core of the western Alps (from the Briançonnais to the Dora Maira massif), and approximately colocated with a similar anomaly observed in a recent teleseismic P-wave tomography. This intriguing anomaly is also supported by traveltime variations of subvertically propagating body waves from two teleseismic events that are approximately located on

  18. Marginal zone B-cell lymphoma with multiple extranodal locations in a patient with Sjögren’s syndrome – a diagnostic problem

    Directory of Open Access Journals (Sweden)

    Marta Domżalska

    2014-09-01

    Full Text Available Sjögren’s syndrome is a chronic autoimmune disease characterized by the presence of lymphocytic infiltrates in exocrine glands, mainly salivary and lacrimal glands, which result in xerophthalmia and xerostomia. About half of the patients develop systemic complications, including lymphoproliferative disorders. We report a case of a 27-year-old woman with a diagnosis of Sjögren’s syndrome and a suspicion of respiratory system involvement in the course of granulomatosis with polyangiitis. Histopathological examination of a skin lesion suggested marginal zone B-cell lymphoma. After pathological and immunohistochemical evaluation of all available previous biopsy samples and the medical documentation the diagnosis of extranodal marginal zone B-cell lymphoma stage IV according to the Ann Arbor classification was rendered. The patient was referred to the Department of Haematology and was treated with R-CVP (cyclophosphamide, vincristine, prednisone, rituximab.

  19. Seckel syndrome: an overdiagnosed syndrome.

    OpenAIRE

    Thompson, E; Pembrey, M

    1985-01-01

    Five children in whom a diagnosis of Seckel syndrome had previously been made were re-examined in the genetic unit. One child had classical Seckel syndrome, a sib pair had the features of the syndrome with less severe short stature, and in two children the diagnosis was not confirmed. Seckel syndrome is only one of a group of low birth weight microcephalic dwarfism and careful attention should be paid to fulfillment of the major criteria defined by Seckel before the diagnosis is made. There r...

  20. Calculation and visualisation of future glacier extent in the Swiss Alps by means of hypsographic modelling

    Science.gov (United States)

    Paul, F.; Maisch, M.; Rothenbühler, C.; Hoelzle, M.; Haeberli, W.

    2007-02-01

    The observed rapid glacier wastage in the European Alps during the past 20 years already has strong impacts on the natural environment (rock fall, lake formation) as well as on human activities (tourism, hydro-power production, etc.) and poses several new challenges also for glacier monitoring. With a further increase of global mean temperature in the future, it is likely that Alpine glaciers and the high-mountain environment as an entire system will further develop into a state of imbalance. Hence, the assessment of future glacier geometries is a valuable prerequisite for various impact studies. In order to calculate and visualize in a consistent manner future glacier extent for a large number of individual glaciers (> 100) according to a given climate change scenario, we have developed an automated and simple but robust approach that is based on an empirical relationship between glacier size and the steady-state accumulation area ratio (AAR 0) in the Alps. The model requires digital glacier outlines and a digital elevation model (DEM) only and calculates new glacier geometries from a given shift of the steady-state equilibrium line altitude (ELA 0) by means of hypsographic modelling. We have calculated changes in number, area and volume for 3062 individual glacier units in Switzerland and applied six step changes in ELA 0 (from + 100 to + 600 m) combined with four different values of the AAR 0 (0.5, 0.6, 0.67, 0.75). For an AAR 0 of 0.6 and an ELA 0 rise of 200 m (400 m) we calculate a total area loss of - 54% (- 80%) and a corresponding volume loss of - 50% (- 78%) compared to the 1973 glacier extent. In combination with a geocoded satellite image, the future glacier outlines are also used for automated rendering of perspective visualisations. This is a very attractive tool for communicating research results to the general public. Our study is illustrated for a test site in the Upper Engadine (Switzerland), where landscape changes above timberline play an

  1. Ethnobotanical and phytomedical knowledge in the North-Western Ligurian Alps.

    Science.gov (United States)

    Cornara, Laura; La Rocca, Arianna; Terrizzano, Luca; Dente, Fulvio; Mariotti, Mauro Giorgio

    2014-08-08

    The ethnobotany of European alpine regions is much diversified and scarcely investigated. These regions retain a well-developed heritage culture and botanical traditional knowledge, favored by the isolated montane location. We carried out a study of therapeutic and traditional uses of native plants of a poorly explored area of the Western Italian Alps in the Ligurian region (NW Italy). The area has been the object of human activities since prehistoric ages, and an obliged crossroad for people moving across Provence, Liguria and Piemonte. The investigation was conducted in the upper Tanarello and Arroscia Valleys by using semi-structured, open interviews. Data were summarized by different indices--Relative Frequency of Citation (RFC), Cultural Value Index (CV), Ethnobotanicity Index (EI) and Informant Consensus Factor (Fic). A group of 65 informants were interviewed, yielding an inventory of 199 botanical taxa from 64 families, and a total of 2661 citations. A total of 13 categories of use were found, of which the most frequent ones were medicinal and food. In addition, 12 main medicinal subcategories were recorded. Botanicals were mainly used to treat digestive system, respiratory system, and the skin. A relevant role was played by plants with digestive and remineralizing properties. On the basis of quantitative analysis (RFC and CV indices) among the 30 most relevant plants are included rare and/or protected species, such as Achillea ligustica, Arnica montana, Gentiana ligustica, Gentiana lutea, and Achillea erba-rotta. An exhaustive prospect of the ethnobotanical knowledge in North-Western Ligurian Alps has been achieved through the recording of a large number of data. About 50% of the recorded uses have survived in the area. A great traditional importance is retained by species such as Artemisia absinthium, Lavandula angustifolia and Arnica montana which were formerly cultivated and marketed for their therapeutic virtues. A substantial role is also attributable

  2. Dams and Development in the French Alps in the Inter-war Period

    Directory of Open Access Journals (Sweden)

    Anne Dalmasso

    2009-03-01

    Full Text Available La vigueur de la « controverse des grands barrages » du début des années 2000 nous amène à nous interroger, dans cet article, sur les conditions de l’accueil fait aux barrages alpins lors de leur première phase de construction dans les années 1920 et 1930. Si l’ampleur des impacts, sociaux et environnementaux est différente, la nature des questions posées concernant les modes d’appropriation et d’usage de l’eau demeure. Au-delà des discours justificateurs ou accusateurs, structurés de façon pérenne autour de la promotion ou de la dénonciation des vertus de la modernisation et du développement, l’acceptabilité des barrages dépend d’abord des perturbations introduites dans la répartition des droits de propriétés et d’usages du territoire et de la capacité à compenser gains et pertes entre les groupes sociaux concernés. Ces questions sont travaillées à partir de deux cas de construction dans les Alpes françaises durant les années 1930, ceux du barrage du Chambon et du Sautet.The heated discussions and controversies over large dams that marked the start of the 21st century have led us in this article to examine the conditions under which Alpine dams were received during the first construction phase of the 1920s and 1930s. Although the extent of social and environ-mental impacts was not the same, the types of questions raised concerning methods of appropriation and uses to which water was put are similar. Among the arguments for and against, which always tend to be structured around the promotion or denunciation of the virtues of modernisation and development, the acceptability of dams depends firstly on the disturbances caused to the distribution of property rights and land usage rights and the ability to balance out gains and losses among the different social groups concerned. These questions are examined in the light of two dams constructed in the French Alps in the 1930s, the Chambon and Sautet dams.

  3. Comparing different methods to model scenarios of future glacier change for the entire Swiss Alps

    Science.gov (United States)

    Linsbauer, A.; Paul, F.; Haeberli, W.

    2012-04-01

    There is general agreement that observed climate change already has strong impacts on the cryosphere. The rapid shrinkage of glaciers during the past two decades as observed in many mountain ranges globally and in particular in the Alps, are impressive confirmations of a changed climate. With the expected future temperature increase glacier shrinkage will likely further accelerate and their role as an important water resource more and more diminish. To determine the future contribution of glaciers to run-off with hydrological models, the change in glacier area and/or volume must be considered. As these models operate at regional scales, simplified approaches to model the future development of all glaciers in a mountain range need to be applied. In this study we have compared different simplified approaches to model the area and volume evolution of all glaciers in the Swiss Alps over the 21st century according to given climate change scenarios. One approach is based on an upward shift of the ELA (by 150 m per degree temperature increase) and the assumption that the glacier extent will shrink until the smaller accumulation area covers again 60% of the total glacier area. A second approach is based on observed elevation changes between 1985 and 2000 as derived from DEM differencing for all glaciers in Switzerland. With a related elevation-dependent parameterization of glacier thickness change and a modelled glacier thickness distribution, the 15-year trends in observed thickness loss are extrapolated into the future with glacier area loss taking place when thickness becomes zero. The models show an overall glacier area reduction between 60-80% until 2100 with some ice remaining at the highest elevations. However, compared to the ongoing temperature increase and considering that several reinforcement feedbacks (albedo lowering, lake formation) are not accounted for, the real area loss might even be stronger. Uncertainties in the modelled glacier thickness have only a

  4. Local Environmental Factors Drive Divergent Grassland Soil Bacterial Communities in the Western Swiss Alps.

    Science.gov (United States)

    Yashiro, Erika; Pinto-Figueroa, Eric; Buri, Aline; Spangenberg, Jorge E; Adatte, Thierry; Niculita-Hirzel, Hélène; Guisan, Antoine; van der Meer, Jan Roelof

    2016-11-01

    Mountain ecosystems are characterized by a diverse range of climatic and topographic conditions over short distances and are known to shelter a high biodiversity. Despite important progress, still little is known on bacterial diversity in mountain areas. Here, we investigated soil bacterial biogeography at more than 100 sampling sites randomly stratified across a 700-km 2 area with 2,200-m elevation gradient in the western Swiss Alps. Bacterial grassland communities were highly diverse, with 12,741 total operational taxonomic units (OTUs) across 100 sites and an average of 2,918 OTUs per site. Bacterial community structure was correlated with local climatic, topographic, and soil physicochemical parameters with high statistical significance. We found pH (correlated with % CaO and % mineral carbon), hydrogen index (correlated with bulk gravimetric water content), and annual average number of frost days during the growing season to be among the groups of the most important environmental drivers of bacterial community structure. In contrast, bacterial community structure was only weakly stratified as a function of elevation. Contrasting patterns were discovered for individual bacterial taxa. Acidobacteria responded both positively and negatively to pH extremes. Various families within the Bacteroidetes responded to available phosphorus levels. Different verrucomicrobial groups responded to electrical conductivity, total organic carbon, water content, and mineral carbon contents. Alpine grassland bacterial communities are thus highly diverse, which is likely due to the large variety of different environmental conditions. These results shed new light on the biodiversity of mountain ecosystems, which were already identified as potentially fragile to anthropogenic influences and climate change. This article addresses the question of how microbial communities in alpine regions are dependent on local climatic and soil physicochemical variables. We benefit from a unique 700

  5. Glacier albedo decrease in the European Alps: potential causes and links with mass balances

    Science.gov (United States)

    Di Mauro, Biagio; Julitta, Tommaso; Colombo, Roberto

    2016-04-01

    Both mountain glaciers and polar ice sheets are losing mass all over the Earth. They are highly sensitive to climate variation, and the widespread reduction of glaciers has been ascribed to the atmospheric temperature increase. Beside this driver, also ice albedo plays a fundamental role in defining mass balance of glaciers. In fact, dark ice absorbs more energy causing faster glacier melting, and this can drive to more negative balances. Previous studies showed that the albedo of Himalayan glaciers and the Greenland Ice Sheet is decreasing with important rates. In this contribution, we tested the hypothesis that also glaciers in the European Alps are getting darker. We analyzed 16-year time series of MODIS (MODerate resolution Imaging Spectrometer) snow albedo from Terra (MOD13A1, 2000-2015) and Aqua (MYD13A1, 2002-2015) satellites. These data feature a spatial resolution of 500m and a daily temporal resolution. We evaluated the existence of a negative linear and nonlinear trend of the summer albedo values both at pixel and at glacier level. We also calculated the correlation between MODIS summer albedo and glacier mass balances (from the World Glaciological Monitoring Service, WGMS database), for all the glaciers with available mass balance during the considered period. In order to estimate the percentage of the summer albedo that can be explained by atmospheric temperature, we correlated MODIS albedo and monthly air temperature extracted from the ERA-Interim reanalysis dataset. Results show that decreasing trends exist with a strong spatial variability in the whole Alpine chain. In large glaciers, such as the Aletch (Swiss Alps), the trend varies significantly also within the glacier, showing that the trend is higher in the area across the accumulation and ablation zone. Over the 17 glaciers with mass balance available in the WGMS data set, 11 gave significant relationship with the MODIS summer albedo. Moreover, the comparison between ERA-Interim temperature

  6. Isolated, but transnational: the glocal nature of Waldensian ethnobotany, Western Alps, NW Italy.

    Science.gov (United States)

    Bellia, Giada; Pieroni, Andrea

    2015-05-07

    An ethnobotanical field study on the traditional uses of wild plants for food as well as medicinal and veterinary plants was conducted in four Waldensian valleys (Chisone, Germanasca, Angrogna, and Pellice) in the Western Alps, Piedmont, NW Italy. Waldensians represent a religious Protestant Christian minority that originated in France and spread around 1,170 AD to the Italian side of Western Alps, where, although persecuted for centuries, approximately 20,000 believers still survive today, increasingly mixing with their Catholic neighbours. Interviews with a total of 47 elderly informants, belonging to both Waldensian and Catholic religious groups, were undertaken in ten Western Alpine villages, using standard ethnobotanical methods. The uses of 85 wild and semi-domesticated food folk taxa, 96 medicinal folk taxa, and 45 veterinary folk taxa were recorded. Comparison of the collected data within the two religious communities shows that Waldensians had, or have retained, a more extensive ethnobotanical knowledge, and that approximately only half of the wild food and medicinal plants are known and used by both communities. Moreover, this convergence is greater for the wild food plant domain. Comparison of the collected data with ethnobotanical surveys conducted at the end of the 19th Century and the 1980s in one of studied valleys (Germanasca) shows that the majority of the plants recorded in the present study are used in the same or similar ways as they were decades ago. Idiosyncratic plant uses among Waldensians included both archaic uses, such as the fern Botrychium lunaria for skin problems, as well as uses that may be the result of local adaptions of Central and Northern European customs, including Veronica allionii and V. officinalis as recreational teas and Cetraria islandica in infusions to treat coughs. The great resilience of plant knowledge among Waldensians may be the result of the long isolation and history of marginalisation that this group has faced

  7. Burnout Syndrome

    OpenAIRE

    Panova, Gordana; Panov, Nenad; Stojanov, H; Sumanov, Gorgi; Panova, Blagica; Stojanovski, Angel; Nikolovska, Lence; Jovevska, Svetlana; Trajanovski, D; Asanova, D

    2013-01-01

    Introduction: Increasing work responsibilities, allocation of duties, loss of energy and motivation in everyday activities, emotional exhaustion, lack of time for themselves, insuffi cient time for rest and recreation, dissatisfaction in private life. All these symptoms can be cause of Burnout Syndrome. Aim: To see the importance of this syndrome, the consequences of job dissatisfaction, the environment, family and expression in drastic chan...

  8. Tourette Syndrome

    Science.gov (United States)

    If you have Tourette syndrome, you make unusual movements or sounds, called tics. You have little or no control over them. Common tics are throat- ... spin, or, rarely, blurt out swear words. Tourette syndrome is a disorder of the nervous system. It ...

  9. Fahr's Syndrome

    Science.gov (United States)

    ... or 50s, although it can occur at any time in childhood or adolescence. × Definition Fahr's Syndrome is a rare, genetically dominant, inherited ... or 50s, although it can occur at any time in childhood or adolescence. View Full Definition Treatment There is no cure for Fahr's Syndrome, ...

  10. Lemierre's syndrome

    DEFF Research Database (Denmark)

    Johannesen, Katrine; Bødtger, Uffe; Heltberg, Ole

    2014-01-01

    Lemierre's syndrome is an often un-diagnosed disease seen in previously healthy young subjects, presenting with symptoms of pharyngitis, fever and elevated markers of inflammation. The syndrome is characterised by infectious thrombosis of the jugular vein due to infection with Fusobacteria, causing...

  11. Ambras syndrome

    Directory of Open Access Journals (Sweden)

    Sudhir Malwade

    2015-01-01

    Full Text Available Ambras syndrome, a form of congenital hypertrichosis lanuginosa, is extremely rare in neonates. It is characterized by typical pattern of hair distribution, dysmorphic facial features and a familial pattern of inheritance. We report a case of Ambras syndrome in a preterm neonate with history of consanguinity and positive family history.

  12. Antiphospholipid syndrome

    DEFF Research Database (Denmark)

    Cervera, Ricard; Piette, Jean-Charles; Font, Josep

    2002-01-01

    To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression.......To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression....

  13. Noonan syndrome

    OpenAIRE

    Roberts, Amy E; Allanson, Judith E; Tartaglia, Marco; Gelb, Bruce D

    2013-01-01

    Noonan syndrome is a genetic multisystem disorder characterised by distinctive facial features, developmental delay, learning difficulties, short stature, congenital heart disease, renal anomalies, lymphatic malformations, and bleeding difficulties. Mutations that cause Noonan syndrome alter genes encoding proteins with roles in the RAS–MAPK pathway, leading to pathway dysregulation. Management guidelines have been developed. Several clinically relevant genotype–phenotype correlations aid ris...

  14. Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease.

    Science.gov (United States)

    Vickers, Mark A; Wilkie, Gwen M; Robinson, Nicolas; Rivera, Nadja; Haque, Tanzina; Crawford, Dorothy H; Barry, Jacqueline; Fraser, Neil; Turner, David M; Robertson, Victoria; Dyer, Phil; Flanagan, Peter; Newlands, Helen R; Campbell, John; Turner, Marc L

    2014-11-01

    Epstein-Barr virus (EBV) is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Conventional treatments for PTLD are often successful, but risk organ rejection and cause significant side effects. EBV-specific cytotoxic T lymphocytes (CTLs) generated in vitro from peripheral blood lymphocytes provide an alternative treatment modality with few side effects, but autologous CTLs are difficult to use in clinical practice. Here we report the establishment and operation of a bank of EBV-specific CTLs derived from 25 blood donors with human leucocyte antigen (HLA) types found at high frequency in European populations. Since licensure, there have been enquiries about 37 patients, who shared a median of three class I and two class II HLA types with these donors. Cells have been infused into ten patients with lymphoproliferative disease, eight of whom achieved complete remission. Neither patient with refractory disease was matched for HLA class II. Both cases of EBV-associated non-haematopoietic sarcoma receiving cells failed to achieve complete remission. Thirteen patients died before any cells could be issued, emphasizing that the bank should be contacted before patients become pre-terminal. Thus, this third party donor-derived EBV-specific CTL cell bank can supply most patients with appropriately matched cells and most recipients have good outcomes. © 2014 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

  15. TAFRO Syndrome.

    Science.gov (United States)

    Igawa, Takuro; Sato, Yasuharu

    2018-02-01

    TAFRO syndrome is a newly recognized variant of idiopathic multicentric Castleman disease (iMCD) that involves a constellation of syndromes: thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Thrombocytopenia and severe anasarca accompanied by relatively low serum immunoglobulin levels are characteristic clinical findings of TAFRO syndrome that are not present in iMCD-not otherwise specified (iMCD-NOS). Lymph node biopsy is recommended to exclude other diseases and to diagnose TAFRO syndrome, which reveals characteristic histopathological findings similar to hyaline vascular-type CD. TAFRO syndrome follows a more aggressive course, compared with iMCD-NOS, and there is no standard treatment. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. [Lessons learned from a distribution incident at the Alps-Mediterranean Division of the French Blood Establishment].

    Science.gov (United States)

    Legrand, D

    2008-11-01

    The Alps-Mediterranean division of the French blood establishment (EFS Alpes-Mediterranée) has implemented a risk management program. Within this framework, the labile blood product distribution process was assessed to identify critical steps. Subsequently, safety measures were instituted including computer-assisted decision support, detailed written instructions and control checks at each step. Failure of these measures to prevent an incident underlines the vulnerability of the process to the human factor. Indeed root cause analysis showed that the incident was due to underestimation of the danger by one individual. Elimination of this type of risk will require continuous training, testing and updating of personnel. Identification and reporting of nonconformities will allow personnel at all levels (local, regional, and national) to share lessons and implement appropriate risk mitigation strategies.

  17. Saharan dust particles in snow samples of Alps and Apennines during an exceptional event of transboundary air pollution.

    Science.gov (United States)

    Telloli, Chiara; Chicca, Milvia; Pepi, Salvatore; Vaccaro, Carmela

    2017-12-21

    Southern European countries are often affected in summer by transboundary air pollution from Saharan dust. However, very few studies deal with Saharan dust pollution at high altitudes in winter. In Italy, the exceptional event occurred on February 19, 2014, colored in red the entire mountain range (Alps and Apennines) and allowed to characterize the particulate matter deposited on snow from a morphological and chemical point of view. Snow samples were collected after this event in four areas in the Alps and one in the Apennines. The particulate matter of the melted snow samples was analyzed by scanning electron microscopy with energy dispersive X-ray spectrometry (SEM-EDS) and by inductively coupled plasma mass spectrometry (ICP-MS). These analyses confirmed the presence of Saharan dust particle components in all areas with similar percentages, supported also by the positive correlations between Mg-Ca, Al-Ca, Al-Mg, and Al-K in all samples.

  18. RISK FACTORS FOR AND SPATIAL DISTRIBUTION OF LYMPHOPROLIFERATIVE DISEASE VIRUS (LPDV) IN WILD TURKEYS (MELEAGRIS GALLOPAVO) IN NEW YORK STATE, USA.

    Science.gov (United States)

    Alger, Katrina; Bunting, Elizabeth; Schuler, Krysten; Whipps, Christopher M

    2017-07-01

    Lymphoproliferative disease virus (LPDV) is an oncogenic avian retrovirus that was previously thought to exclusively infect domestic turkeys but was recently shown to be widespread in Wild Turkeys ( Meleagris gallopavo ) throughout most of the eastern US. In commercial flocks, the virus spreads between birds housed in close quarters, but there is little information about potential risk factors for infection in wild birds. Initial studies focused on distribution of LPDV nationally, but investigation of state-level data is necessary to assess potential predictors of infection and detect patterns in disease prevalence and distribution. We tested wild turkey bone marrow samples (n=2,538) obtained from hunter-harvested birds in New York State from 2012 to 2014 for LPDV infection. Statewide prevalence for those 3 yr was 55% with a 95% confidence interval (CI) of 53-57%. We evaluated a suite of demographic, anthropogenic, and land cover characteristics with logistic regression to identify potential predictors for infection based on odds ratio (OR). Age (OR=0.16, 95% CI=0.13-0.19) and sex (OR=1.3, 95% CI=1.03-1.24) were strong predictors of LPDV infection, with juveniles less likely to test positive than adults, and females more likely to test positive than males. The number of birds released during the state's 40-yr translocation program (OR=0.993, 95% CI=0.990-0.997) and the ratio of agriculture to forest cover (OR=1.13, 95% CI=1.03-1.19) were also predictive of LPDV infection. Prevalence distribution was analyzed using dual kernel density smoothing to produce a risk surface map, combined with Kulldorff's spatial scan statistic and the Anselin Local Moran's I to identify statistically significant geographic clusters of high or low prevalence. These methods revealed the prevalence of LPDV was high (>50%) throughout New York State, with regions of variation and several significant clusters. We revealed new information about the risk factors and distribution of LPDV in New

  19. Chernobyl, 30 years after? Analysis of levels of artificial radioactivity of soils in the Alps in 2015. Analyses and comments report

    International Nuclear Information System (INIS)

    Rougier, G.; Bernollin, A.; Barbey, P.; Boilley, D.; Josset, M.; Paris, A.; Dunand, E.

    2015-01-01

    This report presents radioactivity measurements performed in soil samplings (70 square centimetres, 15 to 20 cm deep core sampling) in several sites located in the French Alps, more particularly in the Hautes-Alpes district (col de Rabou in the Devoluy massif, both sides of the col de la Pisse in the Champsaur, near Gap, Grand Morgon, col de Chorges, col d'Izoard), in the Drome district (different places about Lus-la-Croix-Haute), in the Alpes-de-Haute-Provence district (col de Fontbelle, col de Restefond), in the Savoy district (col du Galibier, Mont-Cenis), and in the Alpes Maritimes district (Le Boreon). It appears that some high levels of caesium-137 contamination are mainly due to Chernobyl, and, to lesser extent, to French nuclear tests. Associated exposure doses are assessed

  20. Favorable outcome of Epstein-Barr virus-associated B-cell lymphoproliferative disorder complicated by immunoglobulin G4-related disease treated with rituximab-based therapy: a case report.

    Science.gov (United States)

    Ueda, Koki; Ikeda, Kazuhiko; Ogawa, Kazuei; Sukegawa, Masumi; Sano, Takahiro; Kimura, Satoshi; Suzuki, Osamu; Hashimoto, Yuko; Takeishi, Yasuchika

    2016-08-24

    After acute infection of Epstein-Barr virus, Epstein-Barr virus-infected B cells survive but usually do not show clonal proliferation. However, Epstein-Barr virus-infected B cells occasionally acquire a proliferative capacity that provokes clonal lymphoproliferative disorders. We herein present a case with Epstein-Barr virus-infected CD30+ B cell and immunoglobulin G4+ plasmacytoid cell proliferation in the lymph nodes, suggesting a pathological and clinical interaction between Epstein-Barr virus-associated B-cell lymphoproliferative disorders and immunoglobulin G4-related disease. Immunoglobulin G4-related disease has been recognized as a benign disease with proliferation of IgG4-related disease+ plasmacytoid cells. Several studies have recently reported the coexistence of immunoglobulin G4-related disease+ plasmacytoid cells with Epstein-Barr virus-infected B cells in lymph nodes in some immunoglobulin G4-related disease cases. However, the pathogenic role of the clonal proliferation of Epstein-Barr virus-infected B cells in immunoglobulin G4-related disease, as well as the treatments for patients with both Epstein-Barr virus-infected B cells and immunoglobulin G4-related disease, have never been discussed. A 50-year-old Japanese man was referred to us for persistent fatigue and lymphadenopathy. His blood examination showed elevated IgG4, and detected high levels of Epstein-Barr virus DNA. A lymph node biopsy revealed IgG4+ plasmacytoid cells and infiltration of large lymphoid cells, which were positive for CD20, CD30, Epstein-Barr virus-related late membrane protein 1, and Epstein-Barr virus-encoded RNA, and were negative for IgG4. Based on the diagnosis of both Epstein-Barr virus-associated B-cell lymphoproliferative disorder and IgG4-related disease, the patient received eight cycles of rituximab combined with cyclophosphamide and prednisolone, which resulted in the complete disappearance of lymphadenopathy. Moreover, his serum IgG4 level was significantly

  1. Morphology and ecology of Daphnia middendorffiana, Fisher 1851 (Crustacea, Daphniidae from four new populations in the Alps

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    Rocco TIBERTI

    2011-08-01

    Full Text Available Daphnia middendorffiana has an arctic, circumpolar distribution, with some isolated southerly populations restricted to mountainous areas, including the Alps. In this paper, new records of Daphnia middendorffiana on the Alps are reported. The species was regularly recorded in several samples collected from 2006 to 2009 in four high altitude lakes in the Gran Paradiso National Park (GPNP during the ice free period. This is the third finding for the Alps and the described populations are the largest. Chemical and morphometric features of the lakes are provided, the morphology of the Daphnia middendorffiana from GPNP is described as well as some aspects concerning its ecology. The studied lakes are small, oligotrophic (total phosphorus ranged from 0 to 7 μg L-1 and well preserved from acidification risk (pH ranged from 6.45 to 8.14. D. middendorffiana is the largest zooplanktonic crustacean inhabiting the Alpine lakes in GPNP reaching 3.43 mm in length; the morphological analysis noted some differences within the studied populations; however there is a clear resemblance to the only Alpine population previously described (from Central Alps, Bognanco Valley, Lake Campo IV and to the arctic populations. D. middendorffiana in GPNP lives at low density levels, reaching higher densities in late August and early September. No males have been found during the sample campaign confirming its ability to produce asexual viable diapauses eggs. This study confirms the attitude of this species for cold and oligotrophic waters and increases the current knowledge on the geographical distribution, morphology and ecology of this species in Alpine environments. The finding of D. middendordorffiana in the GPNP poses interesting issues concerning the phylogeography of Alpine Daphnia middendorffiana, as well as raising need for conservation efforts aimed at keeping the populations safe from several global and local threats, such as climate warming and the ecological

  2. 10Be exposure dating of the timing of Neoglacial glacier advances in the Ecrins-Pelvoux massif, southern French Alps

    Science.gov (United States)

    Le Roy, Melaine; Deline, Philip; Carcaillet, Julien; Schimmelpfennig, Irene; Ermini, Magali; Aster Team

    2017-12-01

    Alpine glacier variations are known to be reliable proxies of Holocene climate. Here, we present a terrestrial cosmogenic nuclide (TCN)-based glacier chronology relying on 24 new 10Be exposure ages, which constrain maximum Neoglacial positions of four small to mid-sized glaciers (Rateau, Lautaret, Bonnepierre and Etages) in the Ecrins-Pelvoux massif, southern French Alps. Glacier advances, marked by (mainly lateral) moraine ridges that are located slightly outboard of the Little Ice Age (LIA, c. 1250-1860 AD) maximum positions, were dated to 4.25 ± 0.44 ka, 3.66 ± 0.09 ka, 2.09 ± 0.10 ka, c. 1.31 ± 0.17 ka and to 0.92 ± 0.02 ka. The '4.2 ka advance', albeit constrained by rather scattered dates, is to our knowledge exposure-dated here for the first time in the Alps. It is considered as one of the first major Neoglacial advance in the western Alps, in agreement with other regional paleoclimatological proxies. We further review Alpine and Northern Hemisphere mid-to-high latitude evidence for climate change and glacier activity concomitant with the '4.2 ka event'. The '2.1 ka advance' was not extensively dated in the Alps and is thought to represent a prominent advance in early Roman times. Other Neoglacial advances dated here match the timing of previously described Alpine Neoglacial events. Our results also suggest that a Neoglacial maximum occurred at Etages Glacier 0.9 ka ago, i.e. during the Medieval Climate Anomaly (MCA, c. 850-1250 AD). At Rateau Glacier, discordant results are thought to reflect exhumation and snow cover of the shortest moraine boulders. Overall, this study highlights the need to combine several sites to develop robust Neoglacial glacier chronologies in order to take into account the variability in moraine deposition pattern and landform obliteration and conservation.

  3. Diversity of bacteria producing pigmented colonies in aerosol, snow and soil samples from remote glacial areas (Antarctica, Alps and Andes)

    OpenAIRE

    González-Toril , E.; Amils , R.; Delmas , R. J.; Petit , J.-R.; Komárek , J.; Elster , J.

    2008-01-01

    Four different communities and one culture of pigmented microbial assemblages were obtained by incubation in mineral medium of samples collected from high elevation snow in the Alps (Mt. Blanc area) and the Andes (Nevado Illimani summit, Bolivia), from Antarctic aerosol (French station Dumont d'Urville) and a maritime Antarctic soil (King George Island, South Shetlands, Uruguay Station Artigas). Molecular analysis of more than 200 16S rRNA gene sequences showed that all cultured cells be...

  4. Investigations on socio economic indicators of French Alps ski industry from an explicit spatial modelling of managed snow on ski slopes

    Science.gov (United States)

    Spandre, Pierre; François, Hugues; Morin, Samuel; George-Marcelpoil, Emmanuelle; Lafaysse, Matthieu

    2017-04-01

    Investigations of the capacity of ski resorts to anticipate, cope with and recover from the impact of natural snow scarcity through snow management (grooming, snowmaking) have been realized in most of the major regions in terms of international ski offer although not in the French Alps hitherto. The present work therefore introduces an innovative approach for the investigation of socio economic implications of changes in snow conditions for the French Alps ski resorts based on a panel of 129 resorts representing 96% of the total French Alps ski lifts infrastructures. We integrated detailed spatial representations of ski resorts (including priority areas for snowmaking equipment) along with physically based snowpack modelling (including the physical impact of grooming and snowmaking). The viability of ski resorts was further adressed thanks to a commonly used rule based on the snow season duration at the village and ski lifts average elevations along with the development of original viability indicators of snow conditions in the French Alps ski resorts based on the specific periods for the economic success of winter sports: Christmas and February school holidays. Such indicators were correlated to the number of ski lifts tickets sales over the 2001 - 2014 period and proved to be relevant to investigate and predict the evolutions of ski lifts tickets sales under the current ski market conditions in the French Alps. Our results outlined the contrast of snow conditions between French Alps ski resorts, even when accounting for snow management, particularly regarding the geographical location of resorts (Southern versus Northern Alps), the size and related elevation range of ski resorts. Our physically based approach also allowed to compute the water and energy requirements for the production of Machine Made snow since the start of the development of snowguns in the French Alps. Our computations proved to be strongly correlated to the observed amounts of water from the

  5. Relating safety, productivity and company type for motor-manual logging operations in the Italian Alps.

    Science.gov (United States)

    Montorselli, Niccolò Brachetti; Lombardini, Carolina; Magagnotti, Natascia; Marchi, Enrico; Neri, Francesco; Picchi, Gianni; Spinelli, Raffaele

    2010-11-01

    The study compared the performance of four different logging crews with respect to productivity, organization and safety. To this purpose, the authors developed a data collection method capable of providing a quantitative analysis of risk-taking behavior. Four crews were tested under the same working conditions, representative of close-to-nature alpine forestry. Motor-manual working methods were applied, since these methods are still prevalent in the specific study area, despite the growing popularity of mechanical processors. Crews from public companies showed a significantly lower frequency of risk-taking behavior. The best safety performance was offered by the only (public) crew that had been administered formal safety training. The study seems to deny the common prejudice that safety practice is inversely proportional to productivity. Instead, productivity is increased by introducing more efficient working methods and equipment. The quantitative analysis of risk-taking behavior developed in this study can be applied to a number of industrial fields besides forestry. Characterizing risk-taking behavior for a given case may eventually lead to the development of custom-made training programmes, which may address problem areas while avoiding that the message is weakened by the inclusion of redundant information. In the specific case of logging crews in the central Alps, the study suggests that current training courses may be weak on ergonomics, and advocates a staged training programme, focusing first on accident reduction and then expanding to the prevention of chronic illness. 2010 Elsevier Ltd. All rights reserved.

  6. Metasomatic tourmalinite formation along basement-cover decollements, Orobic Alps, Italy

    Science.gov (United States)

    Slack, J.F.; Passchier, C.W.; Zhang, J.S.

    1996-01-01

    Cryptocrystalline tourmalinites that occur discontinuously for ???30 km along basement-cover de??collements of the Orohic Alps (Italy) formed by the metasomatism of aluminous cataclasites derived from Permian conglomerates and/or feldspathic sandstones. Using Al as an immobile element monitor, calculations show that the majority of tourmalinites in the region formed through the addition of moderate to significant amounts of B, Mg, Na, Sr, and Be, and the loss of moderate to significant Mn, Ca, K, P, Rb, Ba, and Cr; minor Si, Ti, V, light REE, and Eu also were lost. Data tor relatively immobile Al, Zr, Th, Sc, Nb, and heavy REE indicate that, on average, these tourmalinites formed through ???12% net mass loss assuming an original conglomerate protolith, or through ???7% net mass loss assuming a sandstone protolith. The B and other introduced constituents in the tourmalinites were deposited by hydrothermal fluids focused along and near basement-cover de??collements. These fluids, believed to be associated with late Hercynian felsic magmatism, probably are related to fluids that formed the tourmaline-rich U-Mo-Zn deposits at the nearby Novazza mine and the U-Zn deposits at the nearby Val Vedello mine.

  7. Essential-Oil Variability in Natural Populations of Pinus mugo Turra from the Julian Alps.

    Science.gov (United States)

    Bojović, Srdjan; Jurc, Maja; Ristić, Mihailo; Popović, Zorica; Matić, Rada; Vidaković, Vera; Stefanović, Milena; Jurc, Dušan

    2016-02-01

    The composition and variability of the terpenes and their derivatives isolated from the needles of a representative pool of 114 adult trees originating from four natural populations of dwarf mountain pine (Pinus mugo Turra) from the Julian Alps were investigated by GC-FID and GC/MS analyses. In total, 54 of the 57 detected essential-oil components were identified. Among the different compound classes present in the essential oils, the chief constituents belonged to the monoterpenes, comprising an average content of 79.67% of the total oil composition (74.80% of monoterpene hydrocarbons and 4.87% of oxygenated monoterpenes). Sesquiterpenes were present in smaller amounts (average content of 19.02%), out of which 16.39% were sesquiterpene hydrocarbons and 2.62% oxygenated sesquiterpenes. The most abundant components in the needle essential oils were the monoterpenes δ-car-3-ene, β-phellandrene, α-pinene, β-myrcene, and β-pinene and the sesquiterpene β-caryophyllene. From the total data set of 57 detected compounds, 40 were selected for principal-component analysis (PCA), discriminant analysis (DA), and cluster analysis (CA). The overlap tendency of the four populations suggested by PCA, was as well observed by DA. CA also demonstrated similarity among the populations, which was the highest between Populations I and II. Copyright © 2016 Verlag Helvetica Chimica Acta AG, Zürich.

  8. Catchment features controlling nitrogen dynamics in running waters above the tree line (central Italian Alps

    Directory of Open Access Journals (Sweden)

    R. Balestrini

    2013-03-01

    Full Text Available The study of nitrogen cycling in mountain areas has a long tradition, as it was applied to better understand and describe ecosystem functioning, as well as to quantify long-distance effects of human activities on remote environments. Nonetheless, very few studies, especially in Europe, have considered catchment features controlling nitrogen dynamics above the tree line with focus on running waters. In this study, relationships between some water chemistry descriptors – including nitrogen species and dissolved organic carbon (DOC – and catchment characteristics were evaluated for a range of sites located above the tree line (1950–2650 m a.s.l. at Val Masino, in the central Italian Alps. Land cover categories as well as elevation and slope were assessed at each site. Water samples were collected during the 2007 and 2008 snow free periods, with a nearly monthly frequency. In contrast to dissolved organic nitrogen, nitrate concentrations in running waters showed a spatial pattern strictly connected to the fractional extension of tundra and talus in each basin. Exponential models significantly described the relationships between maximum NO3 and the fraction of vegetated soil cover (negative relation and talus (positive relation, explaining almost 90% of nitrate variation in running waters. Similarly to nitrate but with an opposite behavior, DOC was positively correlated with vegetated soil cover and negatively correlated with talus. Therefore, land cover can be considered one of the most important factors affecting water quality in high-elevation catchments with contrasting effects on N and C pools.

  9. Molecular characterization of phototrophic microorganisms in the forefield of a receding glacier in the Swiss Alps

    Science.gov (United States)

    Frey, Beat; Bühler, Lukas; Schmutz, Stefan; Zumsteg, Anita; Furrer, Gerhard

    2013-03-01

    Recently deglaciated areas are ideal environments to study soil formation and primary microbial succession where phototrophic microorganisms may play a role as primary producers. The aim of our study was to investigate the cyanobacterial and green algal community composition in three different successional stages of the Damma glacier forefield in the Swiss Alps using 16S rDNA and ITS rDNA clone libraries. Cyanobacterial target sequences varied along the glacier forefield, with the highest cyanobacterial 16S rRNA gene copies found in sparsely vegetated soils. Sequence analysis revealed that the phototrophic communities were distinct in each of the three soil environments. The majority of the cyanobacterial sequences retrieved from barren soils were related to the Oscillatoriales. The diversity in sparsely vegetated soils was low, and sequences closely related to Nostoc sp. dominated. The majority of the algal phylotypes are related to members of the Trebouxiophyceae known to live as symbiotic partners in lichens. We conclude that the community composition appears to shift markedly along the chronosequence, indicating that each soil environment selects for its phototrophic community. When cyanobacteria occur together with eukaryotic microalgae, they form a rich source of organic matter and may be important contributors of carbon in nutrient-deficient deglaciated soils.

  10. Molecular characterization of phototrophic microorganisms in the forefield of a receding glacier in the Swiss Alps

    International Nuclear Information System (INIS)

    Frey, Beat; Bühler, Lukas; Schmutz, Stefan; Zumsteg, Anita; Furrer, Gerhard

    2013-01-01

    Recently deglaciated areas are ideal environments to study soil formation and primary microbial succession where phototrophic microorganisms may play a role as primary producers. The aim of our study was to investigate the cyanobacterial and green algal community composition in three different successional stages of the Damma glacier forefield in the Swiss Alps using 16S rDNA and ITS rDNA clone libraries. Cyanobacterial target sequences varied along the glacier forefield, with the highest cyanobacterial 16S rRNA gene copies found in sparsely vegetated soils. Sequence analysis revealed that the phototrophic communities were distinct in each of the three soil environments. The majority of the cyanobacterial sequences retrieved from barren soils were related to the Oscillatoriales. The diversity in sparsely vegetated soils was low, and sequences closely related to Nostoc sp. dominated. The majority of the algal phylotypes are related to members of the Trebouxiophyceae known to live as symbiotic partners in lichens. We conclude that the community composition appears to shift markedly along the chronosequence, indicating that each soil environment selects for its phototrophic community. When cyanobacteria occur together with eukaryotic microalgae, they form a rich source of organic matter and may be important contributors of carbon in nutrient-deficient deglaciated soils. (letter)

  11. Scenario analysis for biodiversity conservation: a social-ecological system approach in the Australian Alps.

    Science.gov (United States)

    Mitchell, Michael; Lockwood, Michael; Moore, Susan A; Clement, Sarah

    2015-03-01

    Current policy interventions are having limited success in addressing the ongoing decline in global biodiversity. In part, this is attributable to insufficient attention being paid to the social and governance processes that drive decisions and can undermine their implementation. Scenario planning that draws on social-ecological systems (SES) analysis provides a useful means to systematically explore and anticipate future uncertainties regarding the interaction between humans and biodiversity outcomes. However, the effective application of SES models has been limited by the insufficient attention given to governance influences. Understanding the influence governance attributes have on the future trajectory of SES is likely to assist choice of effective interventions, as well as needs and opportunities for governance reform. In a case study in the Australian Alps, we explore the potential of joint SES and scenario analyses to identify how governance influences landscape-scale biodiversity outcomes. Novel aspects of our application of these methods were the specification of the focal system's governance attributes according to requirements for adaptive capacity, and constraining scenarios according to the current governance settings while varying key social and biophysical drivers. This approach allowed us to identify how current governance arrangements influence landscape-scale biodiversity outcomes, and establishes a baseline from which the potential benefits of governance reform can be assessed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Global change and upward shift of treeline in the Alps: genetic consequences of pastures colonization

    Directory of Open Access Journals (Sweden)

    Piotti A

    2007-01-01

    Full Text Available In the Alps global warming and change in land use, in particular the drastic reduction in cattle grazing, are causing a progressive treeline ecotone upwards shift. The colonization dynamics of woody species are modulated by high selective pressure on seedlings due to the extreme ecological conditions of this habitat. We studied the colonization dynamics of Norway spruce in a treeline plot, at the upper limit of the Paneveggio forest (Trentino, Italy. We have exhaustively sampled the study stand, collecting needle tissue from all the adults and the juveniles detected, and we have genotyped all the samples (376 with 4 SSR markers. Parentage relationships between the few adults presents in the stand (23 and the juveniles were established. Our results indicate that, in spite of extreme ecological condition of the treeline environment, local adaptations do not seem to favour local parents: only 4% of juveniles have both parents among local adult trees, while 96% of juveniles are completely or partially sired outside the sampling area. Assessing parentage relationship also allowed the estimation of relative reproductive success of local adult trees. Out of a total of 23 adult trees, 5 trees were involved in the 59% of successful reproductive events detected inside the sampling area.

  13. Altitude profiles of total chlorinated paraffins in humus and spruce needles from the Alps (MONARPOP).

    Science.gov (United States)

    Iozza, Saverio; Schmid, Peter; Oehme, Michael; Bassan, Rodolfo; Belis, Claudio; Jakobi, Gert; Kirchner, Manfred; Schramm, Karl-Werner; Kräuchi, Norbert; Moche, Wolfgang; Offenthaler, Ivo; Weiss, Peter; Simoncic, Primoz; Knoth, Wilhelm

    2009-12-01

    Chlorinated paraffins (CPs) are toxic, bioaccumulative, persistent, and ubiquitously present in the environment. CPs were analyzed in humus and needle samples, which were taken within the Monitoring Network in the Alpine Region for Persistent and other Organic Pollutants (MONARPOP) at sampling sites of 7 different altitude profiles in the Alps. Gas chromatography combined with electron ionization tandem mass spectrometry (EI-MS/MS) was used for the determination of total CPs (sum of short, medium and long chain CPs). CPs were found in all samples; the concentrations varied between 7 and 199 ng g(-1) dry weight (dw) and within 26 and 460 ng g(-1) dw in humus and needle samples, respectively. A clear vertical tendency within the individual altitude profiles could not be ascertained. Within all altitude profiles, elevated concentrations were observed in humus samples taken between 700 and 900 m and between 1300 and 1500 m. In the needle samples no similar correlation could be observed due to higher variation of the data.

  14. Climate change impacts on hydropower in the Swiss and Italian Alps.

    Science.gov (United States)

    Gaudard, Ludovic; Romerio, Franco; Dalla Valle, Francesco; Gorret, Roberta; Maran, Stefano; Ravazzani, Giovanni; Stoffel, Markus; Volonterio, Michela

    2014-09-15

    This paper provides a synthesis and comparison of methodologies and results obtained in several studies devoted to the impact of climate change on hydropower. By putting into perspective various case studies, we provide a broader context and improved understanding of climate changes on energy production. We also underline the strengths and weaknesses of the approaches used as far as technical, physical and economical aspects are concerned. Although the catchments under investigation are located close to each other in geographic terms (Swiss and Italian Alps), they represent a wide variety of situations which may be affected by differing evolutions for instance in terms of annual runoff. In this study, we also differentiate between run-of-river, storage and pumping-storage power plants. By integrating and comparing various analyses carried out in the framework of the EU-FP7 ACQWA project, this paper discusses the complexity as well as current and future issues of hydropower management in the entire Alpine region. © 2013 Elsevier B.V. All rights reserved.

  15. Structural complexity at and around the Triassic-Jurassic GSSP at Kuhjoch, Northern Calcareous Alps, Austria

    Science.gov (United States)

    Palotai, M.; Pálfy, J.; Sasvári, Á.

    2017-10-01

    One of the key requirements for a Global Stratotype Section and Point (GSSP) is the absence of tectonic disturbance. The GSSP for the Triassic-Jurassic system boundary was recently defined at Kuhjoch, Northern Calcareous Alps, Austria. New field observations in the area of the Triassic-Jurassic boundary GSSP site demonstrate that the overturned, tight, and almost upright Karwendel syncline was formed at semibrittle deformation conditions, confirmed by axial planar foliation. Tight to isoclinal folds at various scales were related to a tectonic transport to the north. Brittle faulting occurred before and after folding as confirmed by tilt tests (the rotation of structural data by the average bedding). Foliation is ubiquitous in the incompetent units, including the Kendlbach Formation at the GSSP. A reverse fault (inferred to be formed as a normal fault before folding) crosscuts the GSSP sections, results in the partial tectonic omission of the Schattwald Beds, and thus makes it impossible to measure a complete and continuous stratigraphic section across the whole Kendlbach Formation. Based on these observations, the Kuhjoch sections do not fulfil the specific requirement for a GSSP regarding the absence of tectonic disturbances near boundary level.

  16. Alps, Carpathians and Dinarides-Hellenides: about plates, micro-plates and delaminated crustal blocks

    Science.gov (United States)

    Schmid, Stefan

    2014-05-01

    Before the onset of Europe-Africa continental collision in the Dinarides-Hellenides (around 60Ma) and in the Alps and Western Carpathians (around 35 Ma), and at a large scale, the dynamics of orogenic processes in the Mediterranean Alpine chains were governed by Europe-Africa plate convergence leading to the disappearance of large parts of intervening oceanic lithosphere, i.e. the northern branch of Neotethys along the Sava-Izmir-Ankara suture and Alpine Tethys along the Valais-Magura suture (Schmid et al. 2008). In spite of this, two major problems concerning the pre-collisional stage are still poorly understood: (1) by now we only start to understand geometry, kinematics and dynamics of the along-strike changes in the polarity of subduction between Alps-Carpathians and Dinarides-Hellenides, and (2) it is not clear yet during exactly which episodes and to what extent intervening rifted continental fragments such as, for example, Iberia-Briançonnais, Tisza, Dacia, Adria-Taurides moved independently as micro-plates, and during which episodes they remained firmly attached to Europa or Africa from which they broke away. As Europe-Africa plate convergence slowed down well below 1 cm/yr at around 30 Ma ago these pre-collisional processes driven by plate convergence on a global scale gave way to more local processes of combined roll-back and crustal delamination in the Pannonian basin of the Carpathian embayment and in the Aegean (as well as in the Western Mediterranean, not discussed in this contribution). In the case of the Carpathian embayment E-directed roll back totally unrelated to Europe-Africa N-S-directed convergence, started at around 20 Ma ago, due to the presence relict oceanic lithosphere in the future Pannonian basin that remained un-subducted during collision. Due to total delamination of the crust from the eastward rolling back European mantle lithosphere the anticlockwise rotating ALCAPA crustal block, consisting of Eastern Alps and Western Carpathian

  17. Occurrence of PAH in the seasonal snowpack of the Eastern Italian Alps

    Energy Technology Data Exchange (ETDEWEB)

    Gabrieli, Jacopo [Chemical Science Department, University of Padova, via Marzolo 1/A, 35100 Padua (Italy); Environmental Protection Agency of Veneto (ARPAV), Department of Belluno, via Tomea 5, 32100 Belluno (Italy); Department of Environmental Sciences, University Ca' Foscari of Venice, Dorsoduro 2137, 30123 Venice (Italy); Decet, Fabio [Environmental Protection Agency of Veneto (ARPAV), Department of Belluno, via Tomea 5, 32100 Belluno (Italy); Luchetta, Alberto [Environmental Protection Agency of Veneto (ARPAV), Department of Belluno, via Tomea 5, 32100 Belluno (Italy); Arabba Avalanche Center, Environmental Protection Agency of Veneto (ARPAV), via Pradat 5, 32020 Livinallongo del Col di Lana, Belluno (Italy); Valt, Mauro [Arabba Avalanche Center, Environmental Protection Agency of Veneto (ARPAV), via Pradat 5, 32020 Livinallongo del Col di Lana, Belluno (Italy); Pastore, Paolo [Chemical Science Department, University of Padova, via Marzolo 1/A, 35100 Padua (Italy); Barbante, Carlo, E-mail: barbante@unive.i [Department of Environmental Sciences, University Ca' Foscari of Venice, Dorsoduro 2137, 30123 Venice (Italy); Institute for the Dynamics of Environmental Processes - CNR, University of Venice, Dorsoduro 2137, 30123 Venice (Italy)

    2010-10-15

    PAH concentrations have been determined in 47 seasonal snowpack samples collected in the Valbelluna valley and in the Bellunesi Dolomites National Park, in the Italian North-Eastern Alps, during the winter of 2005. The {Sigma}PAH concentration in high-altitude alpine sites (above 1700 m) was 32 {+-} 20 ng/kg while in valley bottom urban areas it was 165 {+-} 54 ng/kg with maximum values of 290 ng/kg. The GIS mapping technique was employed to produce a PAH spatial distribution. The urbanized Valbelluna valley, and in particular the SW part, had the highest accumulation of all PAH, with values an order of magnitude more than those in rural and alpine areas. This behaviour is consistent with urban air quality data, and is due to geo-morphological and meteorological factors such as the deeper shape of the valley at the position of the town of Feltre and the low altitude of the boundary layer during the winter season. - PAH concentrations determined in seasonal snow represent an integration of the winter depositions and can be used to evaluate the pollution levels in an Alpine region.

  18. Occurrence of PAH in the seasonal snowpack of the Eastern Italian Alps

    International Nuclear Information System (INIS)

    Gabrieli, Jacopo; Decet, Fabio; Luchetta, Alberto; Valt, Mauro; Pastore, Paolo; Barbante, Carlo

    2010-01-01

    PAH concentrations have been determined in 47 seasonal snowpack samples collected in the Valbelluna valley and in the Bellunesi Dolomites National Park, in the Italian North-Eastern Alps, during the winter of 2005. The ΣPAH concentration in high-altitude alpine sites (above 1700 m) was 32 ± 20 ng/kg while in valley bottom urban areas it was 165 ± 54 ng/kg with maximum values of 290 ng/kg. The GIS mapping technique was employed to produce a PAH spatial distribution. The urbanized Valbelluna valley, and in particular the SW part, had the highest accumulation of all PAH, with values an order of magnitude more than those in rural and alpine areas. This behaviour is consistent with urban air quality data, and is due to geo-morphological and meteorological factors such as the deeper shape of the valley at the position of the town of Feltre and the low altitude of the boundary layer during the winter season. - PAH concentrations determined in seasonal snow represent an integration of the winter depositions and can be used to evaluate the pollution levels in an Alpine region.

  19. Timing and duration of European larch growing season along altitudinal gradients in the Swiss Alps.

    Science.gov (United States)

    Moser, Lea; Fonti, Patrick; Büntgen, Ulf; Esper, Jan; Luterbacher, Jürg; Franzen, Julia; Frank, David

    2010-02-01

    The 2007 European larch (Larix decidua Mill.) growing season was monitored along two elevational transects in the Lötschental valley in the Swiss Alps. Phenological observations and weekly microcore sampling of 28 larch trees were conducted between April and October 2007 at seven study sites regularly spaced from 1350 to 2150 m a.s.l. on northwest- and southeast-facing slopes. The developmental stages of nearly 75,000 individual cells assessed on 1200 thin sections were used to investigate the links between the trees' thermal regimes and growth phases including the beginning and ending of cell enlargement, wall thickening and maturation of the stem wood. Needles appeared approximately 3-4 weeks earlier than stem growth. The duration of ring formation lasted from mid-May to the end of October, with the length of the growing season decreasing along elevation from 137 to 101 days. The onset of the different growing seasons changed by 3-4 days per 100 m elevation; the ending of the growing season, however, appeared minimally related to altitude. If associated with the monitored altitudinal lapse rate of -0.5 degrees C per 100 m, these results translate into a lengthening of the growing season by approximately 7 days per degree Celsius. This study provides new data on the timing and duration of basic growth processes and contributes to quantification of the impacts of global warming on tree growth and productivity.

  20. On the geology of the uranium mineralization in the Swiss Alps

    International Nuclear Information System (INIS)

    Gillieron, F.

    1988-01-01

    Numerous radiometric anomalies and several uranium occurrences were found in the Swiss Alps by systematic prospecting of selected areas carried out between 1957 and 1984. Most of the uranium indications lie in a rather narrow belt that follows roughly the valleys of the Rhone und of the Rhine Anterior, from Martigny onto Ilanz and extending northwards towards the Lake of Walenstadt. The uranium occurrences were found in the following geological environments: - permocarboniferous continental, variably metamorphosed series, belonging either to the formation of the 'Verrucano' or to the Penninic St. Bernhard nappe; - muscovite-chlorite-albite gneisses belonging to the pre-Westphalian basement of the St. Bernhard nappe; - muscovite-chlorite gneisses and phyllites of the Hercynian Tavetsch massiv; - muscovite-biotite gneisses within the southern border of the Aar massif; - Vallorcine granite of the Auguilles-Rouges massiv and polymetamorphic biotite gneisses along its northwestern contact zone. The possible geological (or 'in situ') resources are estimated to be 50-250 tonnes uranium in each one of the investigated mineralization zones of some importance; the respective estimated grades are 50-250 ppm U. Therefore the occurrences are actually of no economic value. (author) 25 figs., 1 tab., refs

  1. Sensitivity of very small glaciers in the Swiss Alps to future climate change

    Directory of Open Access Journals (Sweden)

    Matthias eHuss

    2016-04-01

    Full Text Available Very small glaciers (<0.5 km2 account for more than 80% of the total number of glaciers in mid- to low-latitude mountain ranges. Although their total area and volume is small compared to larger glaciers, they are a relevant component of the cryosphere, contributing to landscape formation, local hydrology and sea-level rise. Worldwide glacier monitoring mostly focuses on medium-sized to large glaciers leaving us with a limited understanding of the response of dwarf glaciers to climate change. In this study, we present a comprehensive modeling framework to assess past and future changes of very small glaciers at the mountain-range scale. Among other processes our model accounts for snow redistribution, changes in glacier geometry and the time-varying effect of supraglacial debris. It computes the mass balance distribution, the englacial temperature regime and proglacial runoff. The evolution of 1,133 individual glaciers in the Swiss Alps is modeled in detail until 2060 based on new distributed data sets. Our results indicate that 52% of all very small glaciers in Switzerland will completely disappear within the next 25 years. However, a few avalanche-fed glaciers at low elevation might be able to survive even substantial atmospheric warming. We find highly variable sensitivities of very small glaciers to air temperature change, with gently-sloping, low-elevation, and debris-covered glaciers being most sensitive.

  2. Radiocarbon ages of soil charcoals from the southern Alps, Ticino, Switzerland

    International Nuclear Information System (INIS)

    Hajdas, Irka; Schlumpf, Nadia; Minikus-Stary, Nicole; Hagedorn, Frank; Eckmeier, Eileen; Schoch, Werner; Burga, Conradin; Bonani, Georges; Schmidt, Michael W.I.; Cherubini, Paolo

    2007-01-01

    Radiocarbon dating of macroscopic charcoal is a useful tool for paleoclimatic and paleoecologic reconstructions. Here we present results of 14 C dating of charcoals found in charcoal-rich soils of Ticino and the Misox Valley (southern Switzerland) which indicate that the Late Glacial and early Holocene fires coincided with warm phases in the North Atlantic region and low lake levels in the Central Europe. Late Holocene charcoals found in these soils document an earlier than believed presence of sweet chestnut (Castanea sativa Mill.) in southern Switzerland. Sweet chestnut trees play a key role in Mediterranean woodlands, and for longer than two millennia have been used as a food source. Based on palynological evidence it is commonly believed that in southern Switzerland C. sativa was first introduced 2000 years ago by the Romans, who cultivated it for wood and fruit production. Our results indicate that this tree species was present on the southern slopes of the Alps ∼1500 years earlier than previously assumed, and therefore was likely introduced independently from cultivation by the Romans

  3. Driving factors for torrential mass-movements occurrence in the Western Alps

    Directory of Open Access Journals (Sweden)

    Davide eTiranti

    2016-02-01

    Full Text Available To understand the behaviour of torrential processes in the alpine environment, the conditions mainly responsiblefor the occurrence of these phenomena have to be identified and distinguished(classified aspredisposing and triggering factors. In this regard, this study is aimed to understanding which factors lead to the occurrence of a given torrential processes in alpine catchments in the Western Alps, where information on past events are exhaustive and characterized by a long historical series. More than 769 documented torrential eventsoccurred from 1728 to 2015 within 78 catchments. Datasets concerning climate, geology and morphology, land use and the presence of historical landslide activity have been elaborated as input for multivariate statistical analysis to characterize the behaviour of the catchments. The results pinpoint the factors that mainly drive the type of torrential dominant process occurring in a given catchment, its occurrence probability, and its frequency. This study has demonstrated that catchments characterized by a significant percentage of outcropping rocks show a greater occurrence of torrential processes, especially hyperconcentrated flows and debris flows; on the contrary highly vegetated catchments are typically subject to water flows. This result can be a useful tool for the evaluation of hazards related to this specific phenomenon, making it possible to predict the most likely torrential processes that can be generated in a specific basin, given the characteristics of outcropping rock and vegetation cover.

  4. Continuous rainfall simulation for regional flood risk assessment - application in the Austrian Alps

    Science.gov (United States)

    Salinas, Jose Luis; Nester, Thomas; Komma, Jürgen; Blöschl, Günter

    2017-04-01

    Generation of realistic synthetic spatial rainfall is of pivotal importance for assessing regional hydroclimatic hazard as the input for long term rainfall-runoff simulations. The correct reproduction of the observed rainfall characteristics, such as regional intensity-duration-frequency curves, is necessary to adequately model the magnitude and frequency of the flood peaks. Furthermore, the replication of the observed rainfall spatial and temporal correlations allows to model important other hydrological features like antecedent soil moisture conditions before extreme rainfall events. In this work, we present an application in the Tirol region (Austrian alps) of a modification of the model presented by Bardossy and Platte (1992), where precipitation is modeled on a station basis as a mutivariate autoregressive model (mAr) in a Normal space, and then transformed to a Gamma-distributed space. For the sake of simplicity, the parameters of the Gamma distributions are assumed to vary monthly according to a sinusoidal function, and are calibrated trying to simultaneously reproduce i) mean annual rainfall, ii) mean daily rainfall amounts, iii) standard deviations of daily rainfall amounts, and iv) 24-hours intensity duration frequency curve. The calibration of the spatial and temporal correlation parameters is performed in a way that the intensity-duration-frequency curves aggregated at different spatial and temporal scales reproduce the measured ones. Bardossy, A., and E. J. Plate (1992), Space-time model for daily rainfall using atmospheric circulation patterns, Water Resour. Res., 28(5), 1247-1259, doi:10.1029/91WR02589.

  5. Assessment and selection of geomorphosites and trails in the Miage Glacier area (Western Italian alps).

    Science.gov (United States)

    Bollati, Irene; Smiraglia, Claudio; Pelfini, Manuela

    2013-04-01

    Glacial environments are considered geomorphosites because they exhibit all of the features that characterise sites of geomorphological interest. The Miage Glacier, in particular, is the most important debris-covered glacier of the Italian Alps, and it has been extensively studied since the 18th century because of its scientific features. In this area, the geomorphological and geological attributes are evaluated at 11 sites that have been individuated along the three main touristic trails, which allow an exploration of the surroundings of the glacial tongue and its two main lobes. Using a methodology previously tested in a fluvial environment, single sites and trails are quantitatively assessed to determine the most suitable trail for educational purposes. Hazards that could potentially affect the trails are considered in terms of both risk education and final selection of the most suitable trails for the various possible user groups. The richness of scientific data in this area should increase its importance as a geomorphosite by increasing the educational value of the Miage Glacier and the Veny Valley.

  6. Validated thermodynamic prediction of AlP and eutectic (Si) solidification sequence in Al-Si cast alloys

    International Nuclear Information System (INIS)

    Liang, S M; Schmid-Fetzer, R

    2016-01-01

    The eutectic microstructure in hypoeutectic Al-Si cast alloys is strongly influenced by AlP particles which are potent nuclei for the eutectic (Si) phase. The solidification sequence of AlP and (Si) phases is, thus, crucial for the nucleation of eutectic silicon with marked impact on its morphology. This study presents this interdependence between Si- and P-compositions, relevant for Al-Si cast alloys, on the solidification sequence of AlP and (Si). These data are predicted from a series of thermodynamic calculations. The predictions are based on a self-consistent thermodynamic description of the Al-Si-P ternary alloy system developed recently. They are validated by independent experimental studies on microstructure and undercooling in hypoeutectic Al-Si alloys. A constrained Scheil solidification simulation technique is applied to predict the undercooling under clean heterogeneous nucleation conditions, validated by dedicated experimental observations on entrained droplets. These specific undercooling values may be very large and their quantitative dependence on Si and P content of the Al alloy is presented. (paper)

  7. The occurrence of an upper decomposed peat layer, or “kultureller Trockenhorizont”, in the Alps and Jura Mountains

    Directory of Open Access Journals (Sweden)

    P. Sjögren

    2007-06-01

    Full Text Available Many European mires show a layer of increased decomposition and minerogenic content close to the mire surface. Although the phenomenon is widely recognised, there have been few investigations of its distribution, cause and effect. In this study, nine peat profiles from the Alps and Jura Mountains in central Europe were studied to assess general trends in the upper peat stratigraphy. Analyses of pollen and fungal spore content in two profiles indicates that near-surface changes in decomposition are related to recent historical changes in grazing intensity of the surrounding landscape. Reduced trampling pressure and/or decreased nutrient input allowed partial Sphagnum regeneration in the western Alps and Jura Mountains from AD 1940–60, and in the eastern Alps from AD 1820–60. The results are considered in the context of climate and land use, and future implications for mire development in a changing environment are discussed. Many high-altitude mires in the area are now in a Sphagnum peat re-growth state, but future land use and climatic change will determine whether they will develop towards raised bog or forest carr.

  8. A first-principles study of the SCN− chemisorption on the surface of AlN, AlP, and BP nanotubes

    International Nuclear Information System (INIS)

    Soltani, Alireza; Taghartapeh, Mohammad Ramezani; Mighani, Hossein; Pahlevani, Amin Allah; Mashkoor, Reza

    2012-01-01

    Graphical abstract: Adsorption properties of SCN − on AlN, AlP, and BP nanotubes based on density functional theory. ▶ We demonstrate the most stable configurations (N-side) of SCN − on AlN, AlP, and BP nanotubes models. Highlights: ► The SCN − Adsorption on surface of AlN, AlP, and BP nanotubes were studied via density functional theory (DFT). ► The interaction of SCN − on the electronic properties and the NBO charge distribution of mentioned configurations are investigated. ► The studies suggest that the adsorption energies of SCN − on AlPNT is most notable in comparison with AlNNT and BPNT. - Abstract: We have performed first-principles calculations to explore the adsorption behavior of the SCN − on electronic properties of AlN, AlP, and BP nanotubes. The adsorption value of SCN − for the most stable formation on the AlPNT is about −318.16 kJ mol −1 , which is reason via the chemisorptions of SCN anion. The computed density of states (DOS) indicates that a notable orbital hybridization take place between SCN − and AlP nanotube in adsorption process. Finally, the AlP nanotube can be used to design as useful sensor for nanodevice applications.

  9. Goldenhar syndrome

    Directory of Open Access Journals (Sweden)

    Neeraj Sharma

    2013-01-01

    Full Text Available Goldenhar syndrome is a syndrome of complex structures developing from first and second branchial arches during blastogenesis. The etiology of this rare disease is not fully understood, as it has shown itself variable genetically and of unclear causes. The disorder is characterized by a wide spectrum of symptoms and physical features that may vary greatly in range and severity from case to case. Here we present a unique case of Goldenhar syndrome with absence of left condyle, hypoplasia of the zygomatic bone, no pneumatization of the mastoid process, underdeveloped mandible, bifid tongue and the skin tags in the preauricular area.

  10. Cowden syndrome

    Directory of Open Access Journals (Sweden)

    Ravi Prakash S

    2010-01-01

    Full Text Available Cowden syndrome or multiple hamartoma syndrome is an autosomal dominant condition with variable expressions that result mainly from mutation in the PTEN gene on arm 10q. It is characterized by multiple hamartomatous neoplasms of the skin, oral mucosa, gastrointestinal tract, bones, CNS, eyes, and genitourinary tract. Mucocutaneous features include trichilemmomas, oral mucosal papillomatosis, acral keratosis, and palmoplantar keratosis. Here we present a case of Cowden syndrome in a 14-year-old female patient with the chief complaint of multiple oral papillomatous lesions.

  11. Costello syndrome

    Directory of Open Access Journals (Sweden)

    Madhukara J

    2007-01-01

    Full Text Available Costello syndrome is a rare, distinctive, multiple congenital anomaly syndrome, characterized by soft, loose skin with deep palmar and plantar creases, loose joints, distinctive coarse facial features and skeletal and cardiac abnormalities. The affected patients have a predisposition to develop malignancy, developmental delays and mental retardation. Recently, a 7-year-old male child born to normal nonconsanguineous parents presented to us with abnormal facial features, arrhythmia, mitral valve dysfunction and growth retardation. His cutaneous examination revealed lax and pigmented skin over hands and feet with deep creases, acanthosis nigricans and short curly hairs. Its differentiation from other syndromes with similar clinical features is discussed in this article.

  12. Response to rituximab-based therapy and risk factor analysis in epstein barr virus-related lymphoproliferative disorder after hematopoietic stem cell transplant in children and adults: a study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.

    NARCIS (Netherlands)

    Styczynski, J.; Gil, L.; Tridello, G.; Ljungman, P.; Donnelly, J.P.; Velden, W. van der; Omar, H.; Martino, R.; Halkes, C.; Faraci, M.; Theunissen, K.; Kalwak, K.; Hubacek, P.; Sica, S.; Nozzoli, C.; Fagioli, F.; Matthes, S.; Diaz, M.A.; Migliavacca, M.; Balduzzi, A.; Tomaszewska, A.; amara Rde, L. C; Biezen, A. van; Hoek, J. van den; Iacobelli, S.; Einsele, H.; Cesaro, S.

    2013-01-01

    BACKGROUND: The objective of this analysis was to investigate prognostic factors that influence the outcome of Epstein-Barr virus (EBV)-related posttransplant lymphoproliferative disorder (PTLD) after a rituximab-based treatment in the allogeneic hematopoietic stem cell transplant (HSCT) setting.

  13. Kinematics and Seismotectonics of the Montello Thrust Fault (Southeastern Alps, Italy) Revealed by Local GPS and Seismic Networks

    Science.gov (United States)

    Serpelloni, E.; Anderlini, L.; Cavaliere, A.; Danesi, S.; Pondrelli, S.; Salimbeni, S.; Danecek, P.; Massa, M.; Lovati, S.

    2014-12-01

    The southern Alps fold-and-thrust belt (FTB) in northern Italy is a tectonically active area accommodating large part of the ~N-S Adria-Eurasia plate convergence, that in the southeastern Alps ranges from 1.5 to 2.5 mm/yr, as constrained by a geodetically defined rotation pole. Because of the high seismic hazard of northeastern Italy, the area is well monitored at a regional scale by seismic and GPS networks. However, more localized seismotectonic and kinematic features, at the scale of the fault segments, are not yet resolved, limiting our knowledge about the seismic potential of the different fault segments belonging to the southeastern Alps FTB. Here we present the results obtained from the analysis of data collected during local seismic and geodetic experiments conducted installing denser geophysical networks across the Montello-Bassano-Belluno system, a segment of the FTB that is presently characterized by a lower sismicity rate with respect to the surrounding domains. The Montello anticline, which is the southernmost tectonic features of the southeastern Alps FTB (located ~15 km south of the mountain front), is a nice example of growing anticline associated with a blind thrust fault. However, how the Adria-Alps convergence is partitioned across the FTB and the seismic potential of the Montello thrust (the area has been struck by a Mw~6.5 in 1695 but the causative fault is still largely debated) remained still unresolved. The new, denser, GPS data show that this area is undergoing among the highest geodetic deformation rates of the entire south Alpine chain, with a steep velocity gradient across the Montello anticline. The earthquakes recorded during the experiment, precisely relocated with double difference methods, and the new earthquake focal mechanisms well correlate with available information about sub-surface geological structures and highlight the seismotectonic activity of the Montello thrust fault. We model the GPS velocities using elastic

  14. Analysis of topography and relief as a function of the tectonic - geomorphologic evolution of the Eastern Alps

    Science.gov (United States)

    Bungies, Nadin; Rosenberg, Claudio

    2014-05-01

    Alpine topography and relief vary regionally (Frisch et al., 1997), even on the scale of tens of kilometers. The causes of these differences are the aim of this work that is based on a geomorphological study of the eastern Alps. Earlier investigations on the topography of the Central Alps (Rosenberg & Garcia, 2013) show, by using 50 km, 75 km, and 100 km swath profiles, that the relief northward of the Insubric Line increases westward, whereas the relief southwards of the Insubric Line decreases eastward. This trend reflects collisional shortening trends recently observed in the Central Alps (Rosenberg & Kissling, 2013). In this work, we analyse the topography of the eastern Alps from the Brenner Area in the west to the Steiermark Area in the east, based on satellite images and digital terrain models, that cover an area of 36 000 km2 in the Austrian and Italian Alps. Based on these data, new GIS-aided datasets containing selected relief factors have been derived. These data are set in relationship to the eastward decrease in collisional shortening to test whether the latter trend has a geomorphic expression. In order to assess such a relationship north-south striking profiles, subparallel to the shortening direction and in addition to an E-W profile are investigated. It can be shown that the total relief of 3100 m (500-3600 m asl.) in the west of the working area is more pronounced than the total relief of 2300 m (700-3000 m asl) in the east of the working area. Furthermore slopes have higher amplitudes in the west when compared to the east. In the west approximately 65% of the slope profile show slopes larger than 50° while in the east approximately 40% of slopes are larger than 50° (based on 30 m topographic data). The evaluation of potential influencing factors will be achieved by conducting spatial and statistical data analysis and interpretation and is complemented by local studies investigating the evolution of relief for selected geologic units. Here

  15. Climate and vegetation changes during the Lateglacial and early–middle Holocene at Lake Ledro (southern Alps, Italy

    Directory of Open Access Journals (Sweden)

    S. Joannin

    2013-04-01

    Full Text Available Adding to the on-going debate regarding vegetation recolonisation (more particularly the timing in Europe and climate change since the Lateglacial, this study investigates a long sediment core (LL081 from Lake Ledro (652 m a.s.l., southern Alps, Italy. Environmental changes were reconstructed using multiproxy analysis (pollen-based vegetation and climate reconstruction, lake levels, magnetic susceptibility and X-ray fluorescence (XRF measurements recorded climate and land-use changes during the Lateglacial and early–middle Holocene. The well-dated and high-resolution pollen record of Lake Ledro is compared with vegetation records from the southern and northern Alps to trace the history of tree species distribution. An altitude-dependent progressive time delay of the first continuous occurrence of Abies (fir and of the Larix (larch development has been observed since the Lateglacial in the southern Alps. This pattern suggests that the mid-altitude Lake Ledro area was not a refuge and that trees originated from lowlands or hilly areas (e.g. Euganean Hills in northern Italy. Preboreal oscillations (ca. 11 000 cal BP, Boreal oscillations (ca. 10 200, 9300 cal BP and the 8.2 kyr cold event suggest a centennial-scale climate forcing in the studied area. Picea (spruce expansion occurred preferentially around 10 200 and 8200 cal BP in the south-eastern Alps, and therefore reflects the long-lasting cumulative effects of successive boreal and the 8.2 kyr cold event. The extension of Abies is contemporaneous with the 8.2 kyr event, but its development in the southern Alps benefits from the wettest interval 8200–7300 cal BP evidenced in high lake levels, flood activity and pollen-based climate reconstructions. Since ca. 7500 cal BP, a weak signal of pollen-based anthropogenic activities suggest weak human impact. The period between ca. 5700 and ca. 4100 cal BP is considered as a transition period to colder and wetter conditions (particularly during

  16. Carbon dioxide generation and drawdown during active orogenesis of siliciclastic rocks in the Southern Alps, New Zealand

    Science.gov (United States)

    Menzies, Catriona D.; Wright, Sarah L.; Craw, Dave; James, Rachael H.; Alt, Jeffrey C.; Cox, Simon C.; Pitcairn, Iain K.; Teagle, Damon A. H.

    2018-01-01

    Collisional mountain building influences the global carbon cycle through release of CO2 liberated by metamorphic reactions and promoting mechanical erosion that in turn increases chemical weathering and drawdown of atmospheric CO2. The Southern Alps is a carbonate-poor, siliciclastic mountain belt associated with the active Australian Pacific plate boundary. On-going, rapid tectonic uplift, metamorphism and hydrothermal activity are mobilising carbon. Here we use carbon isotope measurements of hot spring fluids and gases, metamorphic host rocks, and carbonate veins to establish a metamorphic carbon budget. We identify three major sources for CO2 within the Southern Alps: (1) the oxidation of graphite; (2) consumption of calcite by metamorphic reactions at the greenschist-amphibolite facies boundary, and (3) the dissolution of groundmass and vein-hosted calcite. There is only a minor component of mantle CO2 arising on the Alpine Fault. Hot springs have molar HCO3-/Ca2+ ∼9, which is substantially higher than produced by the dissolution of calcite indicating that deeper metamorphic processes must dominate. The total CO2 flux to the near surface environment in the high uplift region of the Southern Alps is estimated to be ∼6.4 × 108 mol/yr. Approximately 87% of this CO2 is sourced from coupled graphite oxidation (25%) and disseminated calcite decarbonation (62%) reactions during prograde metamorphism. Dissolution of calcite and mantle-derived CO2 contribute ∼10% and ∼3% respectively. In carbonate-rich orogens CO2 production is dominated by metamorphic decarbonation of limestones. The CO2 flux to the atmosphere from degassing of hot springs in the Southern Alps is 1.9 to 3.2 × 108 mol/yr, which is 30-50% of the flux to the near surface environment. By contrast, the drawdown of CO2 through surficial chemical weathering ranges between 2.7 and 20 × 109 mol/yr, at least an order of magnitude greater than the CO2 flux to the atmosphere from this orogenic belt

  17. Assessing water resources under climate change in high-altitude catchments: a methodology and an application in the Italian Alps

    Science.gov (United States)

    Aili, T.; Soncini, A.; Bianchi, A.; Diolaiuti, G.; D'Agata, C.; Bocchiola, D.

    2018-01-01

    Assessment of the future water resources in the Italian Alps under climate change is required, but the hydrological cycle of the high-altitude catchments therein is poorly studied and little understood. Hydrological monitoring and modeling in the Alps is difficult, given the lack of first hand, site specific data. Here, we present a method to model the hydrological cycle of poorly monitored high-altitude catchments in the Alps, and to project forward water resources availability under climate change. Our method builds on extensive experience recently and includes (i) gathering data of climate, of cryospheric variables, and of hydrological fluxes sparsely available; (ii) robust physically based glacio-hydrological modeling; and (iii) using glacio-hydrological projections from GCM models. We apply the method in the Mallero River, in the central (Retiche) Alps of Italy. The Mallero river covers 321 km2, with altitude between 310 and 4015 m a.s.l., and it has 27 km2 of ice cover. The glaciers included in the catchment underwent large mass loss recently, thus Mallero is largely paradigmatic of the present situation of Alpine rivers. We set up a spatially explicit glacio-hydrological model, describing the cryospheric evolution and the hydrology of the area during a control run CR, from 1981 to 2007. We then gather climate projections until 2100 from three Global Climate Models of the IPCC AR5 under RCP2.6, RCP4.5, and RCP8.5. We project forward flow statistics, flow components (rainfall, snow melt, ice melt), ice cover, and volume for two reference decades, namely 2045-2054 and 2090-2099. We foresee reduction of the ice bodies from - 62 to - 98% in volume (year 2100 vs year 1981), and subsequent large reduction of ice melt contribution to stream flows (from - 61 to - 88%, 2100 vs CR). Snow melt, now covering 47% of the stream flows yearly, would also be largely reduced (from - 19 to - 56%, 2100 vs CR). The stream flows will decrease on average at 2100 (from + 1 to - 25

  18. Constraints on the Miocene landscape evolution of the Eastern Alps from the Kalkspitze region, Niedere Tauern (Austria)

    Science.gov (United States)

    Dertnig, Florian; Stüwe, Kurt; Woodhead, Jon; Stuart, Finlay M.; Spötl, Christoph

    2017-12-01

    In order to unravel aspects of the Miocene landscape evolution of the eastern European Alps, we present geomorphic and isotopic data from the western Niedere Tauern region (Austria). The region is critical for such interpretations, because it is one of the few regions along the topographic axis of the Eastern Alps where the highest peaks (up to 2500 m a.s.l.) are dominated by limestone. As such, the region contains a record of Miocene landscape-forming events that survived the Pleistocene glaciations, not preserved elsewhere in the central Eastern Alps. This record includes karst caves, karstified planation surfaces and crystalline fluvial pebbles (Augenstein Formation) preserved on planation surfaces and in karst caves. Caves in the region occur in three distinct levels that correlate with well-known cave levels in the Northern Calcareous Alps, although they are somewhat higher in the Niedere Tauern. In part, these cave elevations also correlate with three planation surfaces and knickpoints of major streams draining the region, testifying their pre-glacial origin. We report details of a karst cave (Durchgangshöhle) from the highest cave level located at 2340 m a.s.l. In this cave, allochthonous fluvial gravels are present, overgrown by speleothems. One speleothem yielded an early middle Pleistocene U-Pb age (682 ± 17 ka). We regard this as a minimum age for the erosion of the fluvial cave deposits during Marine Isotope Stages 17 or 16. Carbon and oxygen isotope data of these speleothems imply a climate that is consistent with this interpretation. Cosmogenic 21Ne data of fluvial quartz clasts collected from the surface on plateaus of the Northern Calcareous Alps suggest minimum exposure durations of 115 and 262 ka. They probably reflect successive exposure since removal of the sediment cover of the Oligocene Augenstein Formation during the Pleistocene. While our geochronological data fail to record aspects of the earlier Miocene uplift history, they are

  19. Reye Syndrome

    Science.gov (United States)

    ... Legacy Society Make Gifts of Stock Donate Your Car Personal Fundraising Partnership & Support Share Your Story Spread the Word Give While You Shop Contact Us Donate Now What Is Reye’s Syndrome? ...

  20. Alagille Syndrome

    Science.gov (United States)

    ... Legacy Society Make Gifts of Stock Donate Your Car Personal Fundraising Partnership & Support Share Your Story Spread the Word Give While You Shop Contact Us Donate Now Alagille Syndrome Back Alagille ...

  1. Turner Syndrome

    Science.gov (United States)

    ... Failure to begin sexual changes expected during puberty Sexual development that "stalls" during teenage years Early end to menstrual cycles not due to pregnancy For most women with Turner syndrome, inability to ...

  2. [Refeeding syndrome].

    Science.gov (United States)

    Ševela, Stanislav; Novák, František; Kazda, Antonín; Brodská, Helena

    Despite being known more than 60 years, refeeding syndrome (RS) still bears many uncertainties. For example, its definition is not clear and definite, and the attitude to it varies from the complete neglect to over-prevention.The term "refeeding syndrome" refers to electrolyte and metabolic changes occurring in malnourished patients after the readministration of nutrition. These changes concern especially to phosphates and ions. Potassium, magnesium, naturism and fluids balance are involved. The changes lead to cell energetic metabolism and electric potential disturbances, with related clinical symptoms.Fully developed refeeding syndrome is quite rare; nevertheless it can be fatal for the patient. However, even its development can lead to many complications increasing the patient's morbidity and the length of stay in the hospital. Yet the refeeding syndrome is more or less predictable and if kept in mind also preventable.The aim of this article is to get the reader to know more about this metabolic phenomenon and possible attitudes towards it.

  3. Cockayne syndrome

    DEFF Research Database (Denmark)

    Karikkineth, Ajoy C; Scheibye-Knudsen, Morten; Fivenson, Elayne

    2017-01-01

    Cockayne syndrome (CS) is a disorder characterized by a variety of clinical features including cachectic dwarfism, severe neurological manifestations including microcephaly and cognitive deficits, pigmentary retinopathy, cataracts, sensorineural deafness, and ambulatory and feeding difficulties...

  4. Alagille Syndrome

    Science.gov (United States)

    ... Liver Function Tests Clinical Trials Liver Transplant FAQs Medical Terminology Diseases of the Liver Alagille Syndrome Alcohol-Related ... the Liver The Progression of Liver Disease FAQs Medical Terminology HOW YOU CAN HELP Sponsorship Ways to Give ...

  5. Reye Syndrome

    Science.gov (United States)

    ... Liver Function Tests Clinical Trials Liver Transplant FAQs Medical Terminology Diseases of the Liver Alagille Syndrome Alcohol-Related ... the Liver The Progression of Liver Disease FAQs Medical Terminology HOW YOU CAN HELP Sponsorship Ways to Give ...

  6. Turner Syndrome

    Science.gov (United States)

    ... crowding, and osteoporosis (brittle bones). Because of their physical conditions, health concerns, and infertility, some girls and women with TS may have low self- esteem, anxiety, or depression. How is Turner syndrome diagnosed? Physical features may ...

  7. Cushing's Syndrome

    Science.gov (United States)

    ... person cured of Cushing’s syndrome might have some memory loss and slight mental decline. But the change is ... Categories: Family Health, Infants and Toddlers, Kids and Teens, Men, Seniors, WomenTags: acth, adenomas, hormone, sickness September ...

  8. Levator Syndrome

    Science.gov (United States)

    ... Abscess Anorectal Fistula Foreign Objects in the Rectum Hemorrhoids Levator Syndrome Pilonidal Disease Proctitis Rectal Prolapse (See ... out other painful rectal conditions (such as thrombosed hemorrhoids , fissures , or abscesses ). The physical examination is often ...

  9. Alport Syndrome

    Science.gov (United States)

    ... signs and symptoms may differ, based on age, gender and inherited type of Alport syndrome. For example, ... prevention and treatment of kidney disease. The Better Business Bureau Wise Giving Alliance Charity Seal provides the ...

  10. Gilbert's Syndrome

    Science.gov (United States)

    ... not know you have the condition until it's discovered by accident, such as when a blood test ... chemotherapy drug Some protease inhibitors used to treat HIV If you have Gilbert's syndrome, talk to your ...

  11. Potter syndrome

    Science.gov (United States)

    Potter phenotype ... In Potter syndrome, the primary problem is kidney failure. The kidneys fail to develop properly as the baby is ... kidneys normally produce the amniotic fluid (as urine). Potter phenotype refers to a typical facial appearance that ...

  12. Moebius Syndrome

    Science.gov (United States)

    ... delays; high or cleft palate; hearing problems and speech difficulties. Children with Moebius syndrome are unable to move their eyes back and forth. Decreased numbers of muscle fibers have been reported. Deformities of the tongue, jaw, and limbs, such ...

  13. Fraser syndrome

    DEFF Research Database (Denmark)

    Barisic, Ingeborg; Odak, Ljubica; Loane, Maria

    2013-01-01

    Fraser syndrome is a rare autosomal recessive disorder characterized by cryptophthalmos, cutaneous syndactyly, laryngeal, and urogenital malformations. We present a population-based epidemiological study using data provided by the European Surveillance of Congenital Anomalies (EUROCAT) network of...

  14. Angelman Syndrome

    Science.gov (United States)

    ... therapy for seizures is usually necessary. Physical and occupational therapies, communication therapy, and behavioral therapies are important in allowing individuals with Angelman syndrome to reach their maximum developmental potential. × Treatment There ...

  15. Joubert Syndrome

    Science.gov (United States)

    ... CEP290 . View Full Definition Treatment Treatment for Joubert syndrome is symptomatic and supportive. Infant stimulation and physical, occupational, and speech therapy may benefit some children. Infants with abnormal breathing ...

  16. Zellweger Syndrome

    Science.gov (United States)

    ... swallow. Some babies will be born with glaucoma, retinal degeneration, and impaired hearing. Jaundice and gastrointestinal bleeding also may occur. Treatment There is no cure for Zellweger syndrome, nor ...

  17. Nephrotic Syndrome

    Science.gov (United States)

    ... your blood — typically with an artificial kidney machine (dialyzer). Chronic kidney disease. Nephrotic syndrome may cause your ... opportunities Reprint Permissions A single copy of these materials may be reprinted for noncommercial personal use only. " ...

  18. Ohtahara Syndrome

    Science.gov (United States)

    ... are more often affected than girls. View Full Definition Treatment Antiepileptic drugs are used to control seizures, but are unfortunately ... Other therapies are symptomatic and supportive. × ... Definition Ohtahara syndrome is a neurological disorder characterized by ...

  19. Usher Syndrome

    Science.gov (United States)

    ... to abnormal development of the vestibular hair cells, sensory cells that detect gravity and head movement. RP ... 3 Ben-Rebeh, I., et al. (2016). Genetic analysis of Tunisian families with Usher syndrome type 1: ...

  20. Eagle's Syndrome

    OpenAIRE

    Pinheiro,Thaís Gonçalves; Soares,Vítor Yamashiro Rocha; Ferreira,Denise Bastos Lage; Raymundo,Igor Teixeira; Nascimento,Luiz Augusto; Oliveira,Carlos Augusto Costa Pires de

    2013-01-01

    Summary Introduction:?Eagle's syndrome is characterized by cervicopharyngeal signs and symptoms associated with elongation of the styloid apophysis. This elongation may occur through ossification of the stylohyoid ligament, or through growth of the apophysis due to osteogenesis triggered by a factor such as trauma. Elongation of the styloid apophysis may give rise to intense facial pain, headache, dysphagia, otalgia, buzzing sensations, and trismus. Precise diagnosis of the syndrome is diffic...