Tsunami Early Warning System in Italy and involvement of local communities

Science.gov (United States)

Tinti, Stefano; Armigliato, Alberto; Zaniboni, Filippo

2010-05-01

performance of the tsunami predictors. The role of the local communities in defining the strategies in case of uncertain data is essential: only involvement of such communities since the beginning of the planning and implementation phase of the TEWS as well as in the definition of a decision making matrix can ensure appropriate response in case of emergency, and most importantly, the acceptance of the system in the long run. The efforts to implement the Tsunami Warning System in Italy should take into proper account the above mentioned aspects. Involvement of local communities should be primarily realized through the involvement of the local components of the Civil Protection Agency that is responsible for the implementation of the system over the Italian territory. A pilot project is being conducted in cooperation between the Civil Protection Service of Sicily and the University of Bologna (UNIBO) that contemplates the empowering of the local sea-level monitoring system (TSUNET) and specific vulnerability and risk analyses, also exploiting results of national and European research projects (e.g. TRANSFER and SCHEMA) where UNIBO had a primary role.

[Axillary pathologic response after neoadjuvant chemotherapy in locally advanced breast cancer with axillary involvement].

Science.gov (United States)

Jiménez-Ballvé, A; Serrano-Palacio, A; García-Sáenz, J A; Ortega Candil, A; Salsidua-Arroyo, O; Román-Santamaría, J M; Pelayo Alarcón, A; Fuentes Ferrer, M E; Carreras-Delgado, J L

2015-01-01

To compare axillary involvement (N+) at initial staging in locally advanced breast cancer (LABC) with axillary lymphadenectomy histologic results after neoadjuvant chemotherapy treatment (NeoChemo). Retrospective study between November 2011 and September 2013 of LABC cases treated with neoadjuvant chemotherapy based on docetaxel (associated with trastuzumab in HER2 positive cases and carboplatin/adriamycin in HER2 negative cases). Those clinically or radiologically suspected cases of axillary involvement were histologically confirmed. When there was no suspicion of axillary involvement, sentinel lymph node radioguided biopsy (SLNRB) was performed using intradermal injection of (99m)Tc-nanocolloid albumin prior to neoadjuvant treatment. Axillary lymphadenectomy after NeoChemo was undertaken in all cases with positive axilla. Final pathologic response was classified as complete (pCR) when there was no evidence of tumoral disease and as non-pathologic complete response (no pCR) in the opposite case. A total of 346 patients treated with docetaxel were reviewed, identifying 105 LABC. Axillary involvement at initial staging was detected in 70 (67%) before starting NeoChemo. From these 70, 73% (n=51) were N+ (fine needle biopsy and/or biopsy) and the remaining 19 (27%) were occult N+ detected by SLNRB. Axillary lymphadenectomy detected pCR in 56% (39/70), increasing up to 84% pCR when initial N+ status was reached using SNLB. On the other hand, when N+ was detected using fine needle biopsy/lymph biopsy, pCR was only 45%. More than 50% of women affected by locally advanced breast cancer with tumoral axillary involvement at initial diagnosis present free metastatic axilla after therapeutic neoadjuvant chemotherapy effect. This increases up to almost 90% in case of occult metastatic axilla detected with sentinel node biopsy prior starting neoadjuvant chemotherapy. Copyright © 2014 Elsevier España, S.L.U. and SEMNIM. All rights reserved.

Effects of Exposure to Environmental Groups on Student Awareness of Environmental Issues and Their Desire to Be Locally Involved

Science.gov (United States)

Burke, Ann M.

2017-01-01

This study investigated changes in high school students' awareness of environmental issues and their intent to be involved with local environmental groups after attendance at an environmental fair that exposed them to local environmental groups. A comparison of prefair and postfair surveys given to students indicated a highly significant increase…

Helmholtz and Diffusion Equations Associated with Local Fractional Derivative Operators Involving the Cantorian and Cantor-Type Cylindrical Coordinates

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Ya-Juan Hao

2013-01-01

Full Text Available The main object of this paper is to investigate the Helmholtz and diffusion equations on the Cantor sets involving local fractional derivative operators. The Cantor-type cylindrical-coordinate method is applied to handle the corresponding local fractional differential equations. Two illustrative examples for the Helmholtz and diffusion equations on the Cantor sets are shown by making use of the Cantorian and Cantor-type cylindrical coordinates.

Distribution of involved regional lymph nodes in recurrent and locally advanced breast cancer and its impact on target definition

International Nuclear Information System (INIS)

Chen Jian; Ma Jinli; Zhang Shengjian; Yang Zhaozhi; Cai Gang; Feng Yan; Guo Xiaomao; Chen Jiayi

2011-01-01

Objective: The frequency and the anatomic distribution of involved regional nodes in recurrent and locally advanced breast cancer were analyzed, in order to evaluate the rational of conventional regional node radiation technique and provide evidence for target definition of breast cancer . Methods: Patients with recurrent or locally advanced breast cancer who were treated in our hospital from August 2003 to December 2009 were included in this study. 111 patients had contrast enhanced chest CT images of the whole regional nodes before treatment. The regional nodes were categorized into 8 anatomical substructures including medial and lateral supraclavicular nodes ( SC-M, SC-L), axilla nodes ( ALN )- I , II , III, infra clavicular nodes (IFN), Rotter's nodes (RN) and internal mammary nodes (IMN). The frequency of involvement and anatomical distribution of the involved nodes on CT images were analyzed. Results: A total of 111 patients were enrolled this study and 199 anatomical substructures with involved nodes were identified. The frequency of involvement were : SC-M 33, SC-L 21, ALN- I 30, ALN-II 25, ALN-III + IFN 35, RN 27, IMN 28. Supraclavicular region and axilla were the most frequently involved area (72.3%). The average depth of the SC-M and SC-L nodes was 33.48 mm ± 10. 57 mm and 45.62 mm ±20. 45 mm, and 51.5% and 71.4% of the SC-M and SC-L nodes were located more than 3 cm deep from the skin. The axilla nodes were located cranial and caudal to the axillary vein in 5 and 20 locally advanced breast cancer patients and in 64 and 28 patients who received prior axillary dissection. The majority of involved IMN was located within the first 3 intercostal spaces (26/28). The average distance between the center of involved IMN and chest skin was 24. 23 mm ± 10. 28 mm. The average distance between the center of involved IMN and midline of the body was 29. 38 mm ±6. 7 mm. The center of involved IMN was 6.19 mm ±5.73 mm lateral and 5.73 mm ± 4. 56 mm posterior to

Peptide domains involved in the localization of the porcine reproductive and respiratory syndrome virus nucleocapsid protein to the nucleolus

International Nuclear Information System (INIS)

Rowland, Raymond R.R.; Schneider, Paula; Fang Ying; Wootton, Sarah; Yoo, Dongwan; Benfield, David A.

2003-01-01

The nucleocapsid (N) protein of porcine reproductive and respiratory syndrome virus (PRRSV) is the principal component of the viral nucleocapsid and localizes to the nucleolus. Peptide sequence analysis of the N protein of several North American isolates identified two potential nuclear localization signal (NLS) sequences located at amino acids 10-13 and 41-42, which were labeled NLS-1 and NLS-2, respectively. Peptides containing NLS-1 or NLS-2 were sufficient to accumulate enhanced green fluorescent protein (EGFP) in the nucleus. The inactivation of NLS-1 by site-directed mutagenesis or the deletion of the first 14 amino acids did not affect N protein localization to the nucleolus. The substitution of key lysine residues with uncharged amino acids in NLS-2 blocked nuclear/nucleolar localization. Site-directed mutagenesis within NLS-2 identified the sequence, KKNKK, as forming the core localization domain within NLS-2. Using an in vitro pull-down assay, the N protein was able to bind importin-α, importin-β nuclear transport proteins. The localization pattern of N-EGFP fusion peptides represented by a series of deletions from the C- and N-terminal ends of the N protein identified a region covering amino acids 41-72, which contained a nucleolar localization signal (NoLS) sequence. The 41-72 N peptide when fused to EGFP mimicked the nucleolar-cytoplasmic distribution of native N. These results identify a single NLS involved in the transport of N from the cytoplasm and into nucleus. An additional peptide sequence, overlapping NLS-2, is involved in the further targeting of N to the nucleolus

Patterns of failure after involved field radiotherapy for locally advanced esophageal squamous cell carcinoma.

Science.gov (United States)

Li, Duo-Jie; Li, Hong-Wei; He, Bin; Wang, Geng-Ming; Cai, Han-Fei; Duan, Shi-Miao; Liu, Jing-Jing; Zhang, Ya-Jun; Cui, Zhen; Jiang, Hao

2016-01-01

To retrospectively analyze the patterns of failure and the treatment effects of involved-field irradiation (IFI) on patients treated with locally advanced esophageal squamous cell carcinoma (ESCC) and to determine whether IFI is practicable in these patients. A total of 79 patients with locally advanced ESCC underwent three dimensional conformal (3D)CRT) or intensity modulated radiotherapy (IMRT) using IFI or elective nodal irradiation (ENI) according to the target volume. The patterns of failure were defined as local/regional, in-field, out)of)field regional lymph node (LN) and distant failure. With a median follow)up of 32.0 months, failures were observed in 66 (83.6%) patients. The cumulative incidence of local/regional failure (55.8 vs 52.8%) and in)field regional lymph node failure (25.6 vs 19.4%) showed no statistically significant difference between the IFI and the ENI group (p=0.526 and 0.215, respectively). Out)of)field nodal relapse rate of only 7.0% was seen in the IFI group. Three)year survival rates for the ENI and IFI group were 22.2 and 18.6%, respectively (p=0.240), and 3)year distant metastasis rates were 27.8 and 32.6%, respectively (p=0.180). The lung V10, V20, V30 and mean lung dose of the ENI group were greater than those of the IFI group, while the mean lung dose and V10 had statistically significant difference. The patterns of failure and survival rates in the IFI group were similar as in the ENI group; the regional recurrence and distant metastasis are the main cause of treatment failure. IFI is feasible for locally advanced ESCC. Further investigation is needed to increase local control and decrease distant metastasis in these patients.

Putrescine-dependent re-localization of TvCP39, a cysteine proteinase involved in Trichomonas vaginalis cytotoxicity.

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Bertha Isabel Carvajal-Gamez

Full Text Available Polyamines are involved in the regulation of some Trichomonas vaginalis virulence factors such as the transcript, proteolytic activity, and cytotoxicity of TvCP65, a cysteine proteinase (CP involved in the trichomonal cytotoxicity. In this work, we reported the putrescine effect on TvCP39, other CP that also participate in the trichomonal cytotoxicity. Parasites treated with 1,4-diamino-2-butanone (DAB (an inhibitor of putrescine biosynthesis, diminished the amount and proteolytic activity of TvCP39 as compared with untreated parasites. Inhibition of putrescine biosynthesis also reduced ∼ 80% the tvcp39 mRNA levels according to RT-PCR and qRT-PCR assays. Additionally, actinomycin D-treatment showed that the tvcp39 mRNA half-life decreased in the absence of putrescine. However, this reduction was restored by exogenous putrescine addition, suggesting that putrescine is necessary for tvcp39 mRNA stability. TvCP39 was localized in the cytoplasm but, in DAB treated parasites transferred into exogenous putrescine culture media, TvCP39 was re-localized to the nucleus and nuclear periphery of trichomonads. Interestingly, the amount and proteolytic activity of TvCP39 was recovered as well as the tvcp39 mRNA levels were restored when putrescine exogenous was added to the DAB-treated parasites. In conclusion, our data show that putrescine regulate the TvCP39 expression, protein amount, proteolytic activity, and cellular localization.

Complete resection of locally advanced ovarian carcinoma fixed to the pelvic sidewall and involving external and internal iliac vessels.

Science.gov (United States)

Nishikimi, Kyoko; Tate, Shinichi; Matsuoka, Ayumu; Shozu, Makio

2017-08-01

Locally advanced ovarian carcinomas may be fixed to the pelvic sidewall, and although these often involve the internal iliac vessels, they rarely involve the external iliac vessels. Such tumors are mostly considered inoperable. We present a surgical technique for complete resection of locally advanced ovarian carcinoma fixed to the pelvic sidewall and involving external and internal iliac vessels. A 69-year-old woman presented with ovarian carcinoma fixed to the right pelvic sidewall, which involved the right external and internal iliac arteries and veins and the right lower ureter, rectum, and vagina. We cut the external iliac artery and vein at the bifurcation and at the inguinal ligament to resect the external artery and vein. Then, we reconstructed the arterial and venous supplies of the right external artery and vein with grafts. After creating a wide space immediately inside of the sacral plexus to allow the tumor fixed to pelvic sidewall with the internal iliac vessels to move medially, we performed total internal iliac vessel resection. We achieved complete en bloc tumor resection with the right external and internal artery and vein, right ureter, vagina, and rectum adhering to the tumor. There were no intra- or postoperative complications, such as bleeding, graft occlusion, infection, or limb edema. Exfoliation from the sacral plexus and total resection with external and internal iliac vessels enables complete resection of the tumor fixed to the pelvic sidewall. Copyright © 2017 Elsevier Inc. All rights reserved.

User and stakeholder involvement for relevant, reliable and robust local-scale climate projections in Norway

Science.gov (United States)

Neby, Simon; Sobolowski, Stefan

2017-04-01

How can users and stakeholders be actively involved with providing input to and using output from local-scale climate projections? How can the scientific community better understand the needs of local actors? And how should communication and cooperation efforts be organized? These are critical questions we aim to answer in a climate services project funded by the Norwegian Research Council (R3: Relevant, Reliable and Robust local-scale climate projections for Norway). The project takes into consideration not only the scientific issues in establishing useful local-scale climate projections, but also addresses the "usability gap" between climate information and decision-making. The lack of effective communication between scientists and user communities often result in outputs and products that are not matched with decision-relevant climate information. In the R3 project, the scientific participants actively engage with a range of users that have quite different information needs: municipalities, infrastructure developers, agriculture, energy producers, insurance companies, and more. In this particular presentation, we present our experiences concerning three specific issues that relate to the stakeholder-science interface: 1) Preferences are not clear-cut and pre-defined. In practice, this means that stakeholders often do not have precise information about their needs, nor precise information about how, where and whether their needs can be voiced. Similarly, science communities tend to presuppose that stakeholders are interested and have well-articulated needs, which is hardly the case. Collectively, that means that there is a need for an approach that guides the articulation and prioritization of preferences in a manner that integrates both scientific and stakeholder perspectives and takes the integrity of both perspectives seriously. 2) Technologies are unclear. Although information may be produced and used, past experiences, trial and error processes and pragmatic

How Localized are Language Brain Areas? A Review of Brodmann Areas Involvement in Oral Language.

Science.gov (United States)

Ardila, Alfredo; Bernal, Byron; Rosselli, Monica

2016-02-01

The interest in understanding how language is "localized" in the brain has existed for centuries. Departing from seven meta-analytic studies of functional magnetic resonance imaging activity during the performance of different language activities, it is proposed here that there are two different language networks in the brain: first, a language reception/understanding system, including a "core Wernicke's area" involved in word recognition (BA21, BA22, BA41, and BA42), and a fringe or peripheral area ("extended Wernicke's area:" BA20, BA37, BA38, BA39, and BA40) involved in language associations (associating words with other information); second, a language production system ("Broca's complex:" BA44, BA45, and also BA46, BA47, partially BA6-mainly its mesial supplementary motor area-and extending toward the basal ganglia and the thalamus). This paper additionally proposes that the insula (BA13) plays a certain coordinating role in interconnecting these two brain language systems. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Why social science matters in river management: involvement of local stakeholders in monitoring the effects of room for the river measures in the Netherlands

Science.gov (United States)

Verbrugge, Laura; van den Born, Riyan

2015-04-01

The Netherlands is a densely populated delta region with a long tradition in flood protection and river management. In response to climate change, adaptive measures are implemented to create more room for the river (and thus increasing water discharge capacity) while at the same time maintaining the multifunctional use of the river system. These functions include for example navigation, water supply, housing and spatial quality, nature development and recreation. The incorporation of social aspects in water management is vital for the development and implementation of sustainable solutions in environmental planning. Active stakeholder involvement has major benefits in terms of trust, public support, social learning and creative decision making. In practice, however, stakeholder involvement is often confined to one-way communication (e.g. information on websites and public hearings) instead of establishing a dialogue with the relevant local stakeholders. Moreover, stakeholders are often involved too late. Our study focusses on stakeholder perceptions and the opportunities for stakeholder participation and collaboration in river management. One way to actively involve stakeholders and invest in a dialogue is through participatory monitoring, i.e. to involve local stakeholders in collecting, analyzing and evaluating monitoring data. Currently, a pilot engineering intervention (2013-2015) is carried out in the Waal river, i.e. the main Rhine branch in The Netherlands. This intervention comprises the substitution of traditional groynes by a 10 km longitudinal dam and will change the appearance of the fluvial landscape dramatically. An interdisciplinary team of scientists, government representatives and other public and private parties is involved in monitoring the hydrological, ecological and socio-economic effects of the longitudinal dam with the aim to develop and improve models, guidelines and tools for integrative river management. This also provides unique

Bringing the Community into the Process: Issues and Promising Practices for Involving Parents & Business in Local Smart Start Partnerships. UNC Smart Start Evaluation Report.

Science.gov (United States)

Cornish, Mary; Noblit, George

Smart Start is North Carolina's partnership between state government and local leaders, service providers, and families to better serve children under age 6 and their families. The aim of the program is ensuring that all children enter school healthy and ready to learn. This study examined parent and business involvement in local Smart Start…

The value added of conducting regional versus local stakeholder involvement in evaluating technology acceptance

International Nuclear Information System (INIS)

McCabe, G.H.

1995-06-01

Battelle has conducted a three-year effort, funded by the U. S Department of Energy's (DOE) Office of Technology Development, to involve stakeholders in evaluating innovative technologies to clean up volatile organic compound (VOC) contamination at arid sites. Stakeholders have been encouraged to participate in the demonstration of these innovative technologies in order to improve decisions made by DOE and its contractors about technology development, demonstration, and deployment. The basic approach is to identify people and organizations with a stake in the remediation process, and hence in the demonstration of innovative technologies. Stakeholders have included public interest group and environmental group representatives, regulators, technology users, Native Americans, Hispanic community members, and local elected officials. These people are invited to be involved and they are presented with substantive information about the technologies. Their input in terms of identifying issues and concerns, defining the kinds of information needed from the demonstrations, and assessing the acceptability of the technologies for deployment, will help ensure that only broadly promising technologies are carried forward. This approach is designed to increase the likelihood of successful deployment of the new technologies needed to accomplish environmental restoration throughout the DOE complex and at private facilities. The hypothesis in conducting this regional stakeholder involvement program is that there will be different data requirements for different sites due to geographical, institutional, programmatic, and cultural differences at the sites. Identifying the broadest set of data requirements, collecting this information during the technology demonstration, and providing the results of the demonstration to stakeholders will enhance the acceptance of the technology at these sites and, thereby, enhance the technology's deployability

Local Community Involvement and Quality of Life in Tourism Destination Development: Case of Coastal Tourism in West Java, Indonesia

OpenAIRE

Fitri Abdillah

2016-01-01

The community in the tourism destination is one of the key elements to ensure the sustainability of the tourism destination itself. The objective of this study was to determine if the development of tourism contributes to the involvement and the level of quality of life of the local community in Pangandaran and Palabuhanratu. A total of 279 samples were obtained from two locations. Data were analyzed by using descriptive methods to determine the phase of the development of destinations, the c...

eHealth Literacy and Partner Involvement in Treatment Decision Making for Men With Newly Diagnosed Localized Prostate Cancer.

Science.gov (United States)

Song, Lixin; Tatum, Kimberly; Greene, Giselle; Chen, Ronald C

2017-03-01

To examine how the eHealth literacy of partners of patients with newly diagnosed prostate cancer affects their involvement in decision making, and to identify the factors that influence their eHealth literacy.
. Cross-sectional exploratory study.
. North Carolina.
. 142 partners of men with newly diagnosed localized prostate cancer. 
. A telephone survey and descriptive and multiple linear regression analyses were used.
. The partners' eHealth literacy, involvement in treatment decision making, and demographics, and the health statuses of the patients and their partners. 
. Higher levels of eHealth literacy among partners were significantly associated with their involvement in getting a second opinion, their awareness of treatment options, and the size of the social network they relied on for additional information and support for treatment decision making for prostate cancer. The factor influencing eHealth literacy was the partners' access to the Internet for personal use, which explained some of the variance in eHealth literacy.
. This study described how partners' eHealth literacy influenced their involvement in treatment decision making for prostate cancer and highlighted the influencing factors (i.e., partners' access to the Internet for personal use).
. When helping men with prostate cancer and their partners with treatment decision making, nurses need to assess eHealth literacy levels to determine whether nonelectronically based education materials are needed and to provide clear instructions on how to use eHealth resources.

Local Community Involvement and Quality of Life in Tourism Destination Development: Case of Coastal Tourism in West Java, Indonesia

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Fitri Abdillah

2016-10-01

Full Text Available The community in the tourism destination is one of the key elements to ensure the sustainability of the tourism destination itself. The objective of this study was to determine if the development of tourism contributes to the involvement and the level of quality of life of the local community in Pangandaran and Palabuhanratu. A total of 279 samples were obtained from two locations. Data were analyzed by using descriptive methods to determine the phase of the development of destinations, the community involvement, and the level of quality of life  The results showed that (1 Pangandaran has a better destination performance than Palabuhanratu, (2 Pangandaran is in the growth phase and Palabuhanratu is in the consolidation phase, (3 Increase in the number of tourist arrivals in destinations within the growth phase is more influential than that in the consolidation phase, and (4 Among the four components of quality of life, the material aspect has the highest value, followed by the spiritual, social and personal aspects. The development of tourism destinations significantly affected the level of community involvement and the level of quality of life.

Peer Effects and Academics’ Industry Involvement

DEFF Research Database (Denmark)

Aschhoff, Birgit; Grimpe, Christoph

This study explores the interaction between professional imprinting and age in the context of industry-science collaboration. Specifically, we examine the impact of localized and personal peer effects on academics’ involvement with industry and how these effects are moderated by the career age...... of the scientist. We suggest that both localized and personal peer effects drive industry involvement but that the effects from such imprinting are more pronounced for younger researchers, suggesting that professional imprinting takes place in the early stages of a scientist’s academic career. Based on a sample...... of 330 German academics in the field of biotechnology and publication data from the Science Citation Index Expanded (SCIE), we find that scientists with industry-oriented co-authors are more likely to be involved with industry (personal peer effect). Moreover, we find that the scientist’s involvement...

INVOLVEMENT OF LOCAL PUBLIC ADMINISTRATION ON THE DEVELOPMENT OF RURAL TOURISM

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Ionel Barbu

2014-12-01

Full Text Available In this paper we try to show the perception of the main stakeholder on the rural tourism field, local government, on the development of this economic activities. We believe that a revision of an important part of approaches that have appeared in the literature in terms of the concept of rural tourism, in terms of methods of analysis of tourism activities and, not least, requiring the use modern techniques for foresight indicators by which to make assessments on these activities.The local public administration is responsible for policy formulation, research and planning, development of basic infrastructure, the development of certain landmarks, establishing and managing service delivery standards, establishing management measures and recovery planning and environmental protection, setting standards for training and improving employment, setting standards for maintaining public health and safety.In this paper we try to show as well the main factors of the emergence and development of rural tourism in order to establish priorities in the joint action of local people, entrepreneurs, tourists and local and national administrations. In many countries, the tourism industry fall within government priority. Tourism has been identified as one of the primary industries with potential to support local communities in developing economic diversity. In this research, it was also used descriptive analysis of the variables and comparative analysis using Kruskal-Wallis H and Mann-Whitney U test.Kruskal-Wallis H test. The Kruskall-Wallis test aims at comparing several independent samples when, as is the case of our research, the dependent variable is ordinal. The test is based on rank and hierarchy of data analysis. Scores are ranked from lowest to highest, ignoring the groups they belong to, and then calculate the sum of ranks for each of the groups. The question refers to how much respondents considered that are due to the development of rural tourism

Who wants to be involved in health care decisions? Comparing preferences for individual and collective involvement in England and Sweden

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Mio Fredriksson

2017-07-01

Full Text Available Abstract Background Patient and public involvement (PPI is framed as positive for individuals, the health system, public health, as well as for communities and society as a whole. We investigated whether preferences for PPI differed between two countries with Beveridge type health systems–Sweden and England. We measured willingness to be involved in individual treatment decisions and in decisions about the organization and provision of local health and social care services. Methods This was a comparative cross-sectional study of the general population’s preferences. Together, the two samples included 3125 respondents; 1625 in England and 1500 in Sweden. Country differences were analysed in a multinomial regression model controlling for gender, age and educational attainment. Results Overall, 68% of respondents wanted a passive patient role and 44% wanted to be involved in local decisions about organization and provision of services. In comparison with in Sweden, they were in England less likely to want a health professional such as a GP or consultant to make decisions about their treatment and also more likely to want to make their own decisions. They were also less likely to want to be involved in local service development decisions. An increased likelihood of wanting to be involved in organizational decision-making was associated with individuals wanting to make their own treatment decisions. Women were less likely to want health professionals to make decisions and more likely to want to be involved in organizational decisions. Conclusions An effective health system that ensures public health must integrate an effective approach to PPI both in individual treatment decisions and shaping local health and social care priorities. To be effective, involvement activities must take in to account the variation in the desire for involvement and the implications that this has for equity. More work is needed to understand the relationship between the

Women's participation and gender issues in local governance in ...

African Journals Online (AJOL)

Local governance, interpreted as the active involvement of the local population in ensuring improved quality of service and leadership at the local level, involves greater participation by civil society in decision-making processes. The paper examined women's participation and the prevailing gender issues in local ...

Assessment of esophageal involvement in systemic sclerosis and morphea (localized scleroderma) by clinical, endoscopic, manometric and pH metric features: a prospective comparative hospital based study.

Science.gov (United States)

Arif, Tasleem; Masood, Qazi; Singh, Jaswinder; Hassan, Iffat

2015-02-15

Systemic sclerosis (SSc) is a generalized disorder of unknown etiology affecting the connective tissue of the body. It affects the skin and various internal organs. Gastrointestinal tract involvement is seen in almost 90% of the patients. Esophagus is the most frequently affected part of the gastrointestinal tract. Esophageal motility disturbance classically manifests as a reduced lower esophageal sphincter pressure (LESP) and loss of distal esophageal body peristalsis. Consequently, SSc patients may be complicated by erosive esophagitis and eventually by Barrett's esophagus and esophageal adenocarcinoma. Morphea, also known as localized scleroderma, is characterized by predominant skin involvement, with occasional involvement of subjacent muscles and usually sparing the internal organs. The involvement of esophagus in morphea has been studied very scarcely. The proposed study will investigate the esophageal involvement in the two forms of scleroderma (systemic and localized), compare the same and address any need of upper gastrointestinal evaluation in morphea (localized scleroderma) patients. 56 and 31 newly and already diagnosed cases of SSc and morphea respectively were taken up for the study. All the patients were inquired about the dyspeptic symptoms (heartburn and/or acid regurgitation and/or dysphagia). Upper gastrointestinal endoscopy, esophageal manometry and 24-hour pH monitoring were done in 52, 47 and 41 patients of SSc; and 28, 25 and 20 patients of morphea respectively. Esophageal symptoms were present in 39 cases (69.6%) of SSc which were mild in 22 (39.3%), moderate in 14 (25%), severe in three (5.3%); while only four cases (7.1%) of morphea had esophageal symptoms all of which were mild in severity. Reflux esophagitis was seen in 17 cases (32.7%) of SSc and only two cases (7.14%) of morphea. Manometric abnormalities were seen in 32 cases (68.1%) of SSc and none in morphea. Ambulatory 24-hour esophageal pH monitoring documented abnormal reflux in

Mechanisms involved in the differential recovery of CD4 and CD8 T-lymphocytes after local irradiation in mice

International Nuclear Information System (INIS)

De Ruysscher, D; Waer, M.; Vandeputte, M.; Van der Schueren, E.

1990-01-01

The mechanisms involved in the differential recovery of CD4 (helper/inducer phenotype) and CD8 (Cytotoxic/suppressor phenotype) T-lymphocytes after fractionated local irradiation were investigated. In mice, a better recovery of CD4 cells than of CD8 cells was found, while the reverse has been described in humans. Differences in radiosensivitity between CD4 and CD8 mouse splenocytes could not be found. No sequestration of CD8 cells in irradiated tissues could be demonstrated. Irradiation of the thymus did not influence the observed immune changes. Altered thymic production of CD4 and CD8 cells could be excluded by intrathymic injection of FITC (fluorescein isothiocyanate). Hindlimb and tail irradiation did suggest that the differential recovery of CD4 and CD8 T-lymphocytes after local irradiation is determined by extrathymic factors in man and mice, and that the observed differences in immune recovery between man and mice are due to defective thymic function in the former and normal function in the latter. (author). 12 refs.; 5 figs.; 2 tabs

A novel protein involved in heart development in Ambystoma mexicanum is localized in endoplasmic reticulum.

Science.gov (United States)

Jia, P; Zhang, C; Huang, X P; Poda, M; Akbas, F; Lemanski, S L; Erginel-Unaltuna, N; Lemanski, L F

2008-11-01

The discovery of the naturally occurring cardiac non-function (c) animal strain in Ambystoma mexicanum (axolotl) provides a valuable animal model to study cardiomyocyte differentiation. In homozygous mutant animals (c/c), rhythmic contractions of the embryonic heart are absent due to a lack of organized myofibrils. We have previously cloned a partial sequence of a peptide cDNA (N1) from an anterior-endoderm-conditioned-medium RNA library that had been shown to be able to rescue the mutant phenotype. In the current studies we have fully cloned the N1 full length cDNA sequence from the library. N1 protein has been detected in both adult heart and skeletal muscle but not in any other adult tissues. GFP-tagged expression of the N1 protein has revealed localization of the N1 protein in the endoplasmic reticulum (ER). Results from in situ hybridization experiments have confirmed the dramatic decrease of expression of N1 mRNA in mutant (c/c) embryos indicating that the N1 gene is involved in heart development.

Local/regional policies: Acting globally by thinking locally

International Nuclear Information System (INIS)

Hillsman, E.L.

1991-01-01

Policies to reduce greenhouse gas emissions from present levels will require changes in local and regional decision making as well as decisions made at national and multinational scales. A number of cities and states have taken action to reduce emissions either directly or as a byproduct of solving local problems such as air quality. These initiatives represent a potential resource to be mobilized in national policy. A series of case studies is under way to understand the decision making involved and its implications, and to identify ways that national policy might support and benefit from local efforts. Preliminary results from the first of these case studies indicate that reductions in greenhouse gas emissions may be greater when set as a direct target than when resulting as a byproduct of other local problem solving

Representative of local committee

International Nuclear Information System (INIS)

Barcelo, C.

2007-01-01

Carlos Barcelo, spoke about the involvement of local companies in the dismantling project. Local companies realised that they could not undertake the whole project, and informed ENRESA of the tasks in which they would be able to co-operate. On the whole, during the course of the 5-year project the local and regional firms were given more work than they had originally expected. Mr. Barcelo praised the good partnership that evolved between the local firms and the implementer. (author)

Sacroplasty for Local or Massive Localization of Multiple Myeloma

International Nuclear Information System (INIS)

Basile, Antonio; Tsetis, Dimitrios; Cavalli, Maide; Fiumara, Paolo; Raimondo, Francesco Di; Coppolino, Francesco; Coppolino, Carmelo; Mundo, Elena; Desiderio, Carla; Granata, Antonio; Patti, Maria Teresa

2010-01-01

The purpose of this study was to assess the efficacy of cementoplasty in the treatment of sacral multiple myelomas. We retrospectively reviewed the records of eight patients (four women and four men; age range 47-68 years; mean age 57.8) who underwent cementoplasty for painful osteolytic localization of multiple myeloma between April 2007 and May 2009. The patients had difficulty walking because of increasing pain. Six patients had persistent pain despite other cementoplasties for vertebral and femoral localization, whereas two patients referred at the time of diagnosis had only sacral lesions. The clinical indication for treatment was (1) a pain intensity score ≥5 on visual analogue scale (VAS) and (2) pain totally or partially refractory to analgesic treatment in patients with a life expectancy >3 months. Technical planning was based on computed tomography and/or magnetic resonance imaging. Six patients had previously undergone radiotherapy or chemotherapy and were receiving varying doses of analgesics, whereas sacroplasty represented the first treatment for two patients. Five patients had monolateral local involvement, and the other patients had massive involvement of the sacrum; Technical success was achieved in all cases. We had only one small and asymptomatic foraminal leak. All patients experienced improvement in symptoms after the procedure, as demonstrated by improved VAS scores and performance status (PS) and decreased analgesic dose constant during follow-up. In our experience, percutaneous stabilization can be used effectively and safely in patients with focal or extensive involvement of the sacrum by multiple myeloma.

Localized scleroderma: clinical spectrum and therapeutic update.

Science.gov (United States)

Careta, Mariana Figueiroa; Romiti, Ricardo

2015-01-01

Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea which classically presents benign and self-limited evolution and is confined to the skin and/or underlying tissues. Localized scleroderma is a rare disease of unknown etiology. Recent studies show that the localized form may affect internal organs and have variable morbidity. Treatment should be started very early, before complications occur due to the high morbidity of localized scleroderma. In this review, we report the most important aspects and particularities in the treatment of patients diagnosed with localized scleroderma.

Localized scleroderma: clinical spectrum and therapeutic update*

Science.gov (United States)

Careta, Mariana Figueiroa; Romiti, Ricardo

2015-01-01

Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea which classically presents benign and self-limited evolution and is confined to the skin and/or underlying tissues. Localized scleroderma is a rare disease of unknown etiology. Recent studies show that the localized form may affect internal organs and have variable morbidity. Treatment should be started very early, before complications occur due to the high morbidity of localized scleroderma. In this review, we report the most important aspects and particularities in the treatment of patients diagnosed with localized scleroderma. PMID:25672301

Setting up local community wind energy projects

International Nuclear Information System (INIS)

Larke, Charmian.

1993-01-01

A report is given on progress to establish a company in the UK which involves local people at an early stage in the development of wind farms. Particular attention is paid to obtaining local finance for the projects. Because rural communities tend to be relatively poor, larger investors will need to be involved. (UK)

Building Local Governance in Denmark

DEFF Research Database (Denmark)

Damgaard, Bodil

local level actors through partnerships and networks and discuss how such involvement may improve societal regulation. The paper analyses the apparent paradox that local partnerships are mandated though hierarchical structures (law) and discusses the consequences hereof with regard to central features...

Neurologic involvement in scleroderma: a systematic review.

Science.gov (United States)

Amaral, Tiago Nardi; Peres, Fernando Augusto; Lapa, Aline Tamires; Marques-Neto, João Francisco; Appenzeller, Simone

2013-12-01

To perform a systematic review of neurologic involvement in Systemic sclerosis (SSc) and Localized Scleroderma (LS), describing clinical features, neuroimaging, and treatment. We performed a literature search in PubMed using the following MeSH terms, scleroderma, systemic sclerosis, localized scleroderma, localized scleroderma "en coup de sabre", Parry-Romberg syndrome, cognitive impairment, memory, seizures, epilepsy, headache, depression, anxiety, mood disorders, Center for Epidemiologic Studies Depression (CES-D), SF-36, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Patient Health Questionnaire-9 (PHQ-9), neuropsychiatric, psychosis, neurologic involvement, neuropathy, peripheral nerves, cranial nerves, carpal tunnel syndrome, ulnar entrapment, tarsal tunnel syndrome, mononeuropathy, polyneuropathy, radiculopathy, myelopathy, autonomic nervous system, nervous system, electroencephalography (EEG), electromyography (EMG), magnetic resonance imaging (MRI), and magnetic resonance angiography (MRA). Patients with other connective tissue disease knowingly responsible for nervous system involvement were excluded from the analyses. A total of 182 case reports/studies addressing SSc and 50 referring to LS were identified. SSc patients totalized 9506, while data on 224 LS patients were available. In LS, seizures (41.58%) and headache (18.81%) predominated. Nonetheless, descriptions of varied cranial nerve involvement and hemiparesis were made. Central nervous system involvement in SSc was characterized by headache (23.73%), seizures (13.56%) and cognitive impairment (8.47%). Depression and anxiety were frequently observed (73.15% and 23.95%, respectively). Myopathy (51.8%), trigeminal neuropathy (16.52%), peripheral sensorimotor polyneuropathy (14.25%), and carpal tunnel syndrome (6.56%) were the most frequent peripheral nervous system involvement in SSc. Autonomic neuropathy involving cardiovascular and gastrointestinal systems was regularly described

Accumulation of cynaropicrin in globe artichoke and localization of enzymes involved in its biosynthesis.

Science.gov (United States)

Eljounaidi, K; Comino, C; Moglia, A; Cankar, K; Genre, A; Hehn, A; Bourgaud, F; Beekwilder, J; Lanteri, S

2015-10-01

Globe artichoke (Cynara cardunculus var. scolymus) belongs to the Asteraceae family, in which one of the most biologically significant class of secondary metabolites are sesquiterpene lactones (STLs). In globe artichoke the principal STL is the cynaropicrin, which contributes to approximately 80% of its characteristic bitter taste. Cynaropicrin content was assessed in globe artichoke tissues and was observed to accumulate in leaves of different developmental stages. In the receptacle, a progressive decrease was observed during inflorescence development, while the STL could not be detected in the inflorescence bracts. Almost undetectable amounts were found in the roots and inflorescence stems at the commercial stage. Cynaropicrin content was found to correlate with expression of genes encoding CcGAS, CcGAO and CcCOS, which are involved in the STL biosynthesis. A more detailed study of leaf material revealed that cynaropicrin predominantly accumulates in the trichomes, and not in the apoplastic cavity fluids. Analysis of the promoter regions of CcGAO and CcCOS revealed the presence of L1-box motifs, which confers trichome-specific expression in Arabidopsis, suggesting that cynaropicrin is not only stored but also synthesized in trichomes. A transient expression of GFP fusion proteins was performed in Nicotiana benthamiana plants: the CcGAS fluorescence signal was located in the cytoplasm while the CcGAO and CcCOS localized to the endoplasmatic reticulum. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

18F-FDG PET for detecting recurrent head and neck cancer, local lymph node involvement and distant metastases. Comparison of qualitative visual and semiquantitative analysis

International Nuclear Information System (INIS)

Schmidt, M.; Schmalenbach, M.; Theissen, P.; Dietlein, M.; Eschner, W.; Schicha, H.; Jungehuelsing, M.; Schroeder, U.; Stennert, E.

2004-01-01

Aim: Assessment of the clinical value of 18 F-FDG-PET for detection of recurrent head and neck cancer, local lymph node involvement and distant metastases comparing a qualitative visual with a semiquantitative analysis (SUV values). Patients, methods: Retrospective evaluation of 73 18 F-FDG PET studies in 55 patients by use of a four-step qualitative visual grading system and calculation of standard uptake values in pathological lesions. Calculation of SUV values in normal regions for generating a map of physiological 18 F-FDG distribution. Correlation to histopathological findings and clinical follow-up. Results: 1. Qualitative visual analysis of 18 F-FDG PET studies: a) local recurrence sensitivity 79%, specificity 97%, positive predictive value 95%, negative predictive value 85%, and diagnostic accuracy 89%; b) local metastatic lymph nodes 100%, 95%, 85%, 100%, 96%; c) distant metastases 100%, 98%, 86%, 100%, 98%, respectively. 2. Semiquantitative analysis had only little incremental, non-significant value in comparison to qualitative visual analysis for the detection of a local recurrence in two patients: a) local recurrence: sensitivity 83%, specificity 100%, positive predictive value 100%, negative predictive value 88%, and diagnostic accuracy 93%; b) local metastatic lymph nodes or c) distant metastases did not change in comparison to qualitative visual analysis. Conclusion: 18 F-FDG PET is an effective tool for re-staging of patients with suspected recurrence after therapy for head and neck cancer. (orig.)

Policy integration and public involvement in the local policy process: lessons from local green planning in the Netherland

NARCIS (Netherlands)

Coenen, Franciscus H.J.M.

1998-01-01

Agenda 21 explicitly recommends the use of existing planning experience when drawing up sustainable development strategies. Many local authorities all over the world have gained experience with so-called green planning, and green plans were already addressing the escalating environmental problems

Online Citizens - Does the Net Add Something New to the Local Public and Local Politics?

Directory of Open Access Journals (Sweden)

Lars Torpe

2006-09-01

Full Text Available The article discusses the skeptical view that on-line forms of politial participation have thus far had only little importance for democracy. Based on an analysis of the interplay between the supply of, and the demands for, e-tools for political informaiton and deliberation at the local level in Denmark, it is concluded that the skeptical view is con- firmed to some extent; however, It is also shown that something more - as well as something new - is added to the local political public, both in terms of the citizens involved and the topics discussed. Further- more, the case study indicates that online deliberations have had a number of minor effects on local political opinionformation and deci- sion-making. Thus, the overall conclusion is that a local forum of digital deliberations has the potential to form an alternative channel for raising issues and forming a vehicle for involving more citizens in politics, including citizens with weak resources.

Uncovering genes and ploidy involved in the high diversity in root hair density, length and response to local scarce phosphate in Arabidopsis thaliana.

Directory of Open Access Journals (Sweden)

Markus G Stetter

Full Text Available Plant root hairs increase the root surface to enhance the uptake of sparingly soluble and immobile nutrients, such as the essential nutrient phosphorus, from the soil. Here, root hair traits and the response to scarce local phosphorus concentration were studied in 166 accessions of Arabidopsis thaliana using split plates. Root hair density and length were correlated, but highly variable among accessions. Surprisingly, the well-known increase in root hair density under low phosphorus was mostly restricted to genotypes that had less and shorter root hairs under P sufficient conditions. By contrast, several accessions with dense and long root hairs even had lower hair density or shorter hairs in local scarce phosphorus. Furthermore, accessions with whole-genome duplications developed more dense but phosphorus-insensitive root hairs. The impact of genome duplication on root hair density was confirmed by comparing tetraploid accessions with their diploid ancestors. Genome-wide association mapping identified candidate genes potentially involved in root hair responses tp scarce local phosphate. Knock-out mutants in identified candidate genes (CYR1, At1g32360 and RLP48 were isolated and differences in root hair traits in the mutants were confirmed. The large diversity in root hair traits among accessions and the diverse response when local phosphorus is scarce is a rich resource for further functional analyses.

La formule des traces locale tordue

CERN Document Server

Moeglin, Colette

2018-01-01

A note to readers: This book is in French. The text has two chapters. The first one, written by Waldspurger, proves a twisted version of the local trace formula of Arthur over a local field. This formula is an equality between two expressions, one involving weighted orbital integrals, the other one involving weighted characters. The authors follow Arthur's proof, but the treatement of the spectral side is more complicated in the twisted situation. They need to use the combinatorics of the "Morning Seminar". The authors' local trace formula has the same consequences as in Arthur's paper on elliptic characters. The second chapter, written by Moeglin, gives a symmetric form of the local trace formula as in Arthur's paper on Fourier Transform of Orbital integral and describes any twisted orbital integral, in the p-adic case, as integral of characters.

Computed tomography of iliopsoas involvement in uterine cervix cancer

International Nuclear Information System (INIS)

Chung, Jin Uk; Choi, Byung Ihn; Kim, Seung Hyup; Han, Man Chung; Kim, Chu Wan

1987-01-01

Uterine cervix carcinomas spread by direct local extension, lymphatic permeation and hematogenous dissemination. Their metastatic foci are closely related to iliopsoas compartment anatomically no matter what the pattern of spread is. Therefore, iliopsoas involvement in uterine cervix cancer may occur frequently. The authors reviewed pelvis CT of 218 cervix cancer patients for recent one year from March 1986 to February 1987 at Seoul National University Hospital. Among them, 10 cases showed iliopsoas involvement. Pattern of iliopsoas involvement was classified into four types: infiltrative type (three cases), localized mass type (three cases), mass with bone destruction type (two cases), paraaortic lymphadenopathy type (two cases). In all cases except 3 cases of infiltrative type, lymphadenopathy or bone metastasis adjacent to iliopsoas lesion was identified. And this finding suggested that the route of iliopsoas involvement in cervix cancer would be secondary infiltration from metastatic focus of adjacent lymph node or bone. Recognition of iliopsoas involvement of cervix caner may prevent misdiagnosis and predict the degree of disease dissemination

Central localization of plasticity involved in appetitive conditioning in Lymnaea

OpenAIRE

Straub, Volko A.; Styles, Benjamin J.; Ireland, Julie S.; O'Shea, Michael; Benjamin, Paul R.

2004-01-01

Learning to associate a conditioned (CS) and unconditioned stimulus (US) results in changes in the processing of CS information. Here, we address directly the question whether chemical appetitive conditioning of Lymnaea feeding behavior involves changes in the peripheral and/or central processing of the CS by using extracellular recording techniques to monitor neuronal activity at two stages of the sensory processing pathway. Our data show that appetitive conditioning does not affect signific...

48 CFR 752.225-71 - Local procurement.

Science.gov (United States)

2010-10-01

... 1997) (a) Local procurement involves the use of appropriated funds to finance the procurement of goods... currency of the cooperating country. (b) All locally-financed procurements must be covered by source/origin...

A hybrid local/non-local framework for the simulation of damage and fracture

KAUST Repository

Azdoud, Yan

2014-01-01

Recent advances in non-local continuum models, notably peridynamics, have spurred a paradigm shift in solid mechanics simulation by allowing accurate mathematical representation of singularities and discontinuities. This doctoral work attempts to extend the use of this theory to a community more familiar with local continuum models. In this communication, a coupling strategy - the morphing method -, which bridges local and non-local models, is presented. This thesis employs the morphing method to ease use of the non-local model to represent problems with failure-induced discontinuities. First, we give a quick review of strategies for the simulation of discrete degradation, and suggest a hybrid local/non-local alternative. Second, we present the technical concepts involved in the morphing method and evaluate the quality of the coupling. Third, we develop a numerical tool for the simulation of the hybrid model for fracture and damage and demonstrate its capabilities on numerical model examples

The Involvement of Rural Entrepreneurship In The Regional Development

Directory of Open Access Journals (Sweden)

Marin Burcea

2014-12-01

Full Text Available The aims of the present paper are to emphasize the importance of the rural entrepreneurship involvement in the regional development and to analyse the results of a research regarding the cooperation between the stakeholders of the local and regional development. A set of two hypotheses has been tested by using the data of a sociological survey focused on entrepreneurship and on the potential entrepreneurs from the rural area, belonging to five development regions. The results of our research highlight that the relationships between the rural area business environment and the other actors involved in the regional development (local public authorities, professional associations, institutions centred on regional development are influenced by the framework of organisation and cooperation with the local business environment.

Parental Involvement and the Theory of Planned Behavior

Science.gov (United States)

Bracke, Deborah; Corts, Daniel

2012-01-01

The "Theory of Planned Behavior" provided a specific theoretical framework to evaluate the impact of attitudes, norms, and controls on parental involvement in a local school district. The "new knowledge" that resulted from the measurement of these constructs affirmed that regardless of the perceived level of parental involvement, virtually all…

Musculoskeletal MRI findings of juvenile localized scleroderma

Energy Technology Data Exchange (ETDEWEB)

Eutsler, Eric P. [Nemours Children' s Health System/Alfred I. duPont Hospital for Children, Wilmington, DE (United States); Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, MO (United States); Horton, Daniel B. [Nemours Children' s Health System/Alfred I. duPont Hospital for Children, Division of Rheumatology, Department of Pediatrics, Wilmington, DE (United States); Rutgers Robert Wood Johnson Medical School, Department of Pediatrics, New Brunswick, NJ (United States); Epelman, Monica [Nemours Children' s Health System/Nemours Children' s Hospital, Department of Medical Imaging, Orlando, FL (United States); Finkel, Terri [Nemours Children' s Health System/Nemours Children' s Hospital, Department of Pediatrics, Orlando, FL (United States); Averill, Lauren W. [Nemours Children' s Health System/Alfred I. duPont Hospital for Children, Wilmington, DE (United States)

2017-04-15

Juvenile localized scleroderma comprises a group of autoimmune conditions often characterized clinically by an area of skin hardening. In addition to superficial changes in the skin and subcutaneous tissues, juvenile localized scleroderma may involve the deep soft tissues, bones and joints, possibly resulting in functional impairment and pain in addition to cosmetic changes. There is literature documenting the spectrum of findings for deep involvement of localized scleroderma (fascia, muscles, tendons, bones and joints) in adults, but there is limited literature for the condition in children. We aimed to document the spectrum of musculoskeletal magnetic resonance imaging (MRI) findings of both superficial and deep juvenile localized scleroderma involvement in children and to evaluate the utility of various MRI sequences for detecting those findings. Two radiologists retrospectively evaluated 20 MRI studies of the extremities in 14 children with juvenile localized scleroderma. Each imaging sequence was also given a subjective score of 0 (not useful), 1 (somewhat useful) or 2 (most useful for detecting the findings). Deep tissue involvement was detected in 65% of the imaged extremities. Fascial thickening and enhancement were seen in 50% of imaged extremities. Axial T1, axial T1 fat-suppressed (FS) contrast-enhanced and axial fluid-sensitive sequences were rated most useful. Fascial thickening and enhancement were the most commonly encountered deep tissue findings in extremity MRIs of children with juvenile localized scleroderma. Because abnormalities of the skin, subcutaneous tissues and fascia tend to run longitudinally in an affected limb, axial T1, axial fluid-sensitive and axial T1-FS contrast-enhanced sequences should be included in the imaging protocol. (orig.)

Musculoskeletal MRI findings of juvenile localized scleroderma

International Nuclear Information System (INIS)

Eutsler, Eric P.; Horton, Daniel B.; Epelman, Monica; Finkel, Terri; Averill, Lauren W.

2017-01-01

Juvenile localized scleroderma comprises a group of autoimmune conditions often characterized clinically by an area of skin hardening. In addition to superficial changes in the skin and subcutaneous tissues, juvenile localized scleroderma may involve the deep soft tissues, bones and joints, possibly resulting in functional impairment and pain in addition to cosmetic changes. There is literature documenting the spectrum of findings for deep involvement of localized scleroderma (fascia, muscles, tendons, bones and joints) in adults, but there is limited literature for the condition in children. We aimed to document the spectrum of musculoskeletal magnetic resonance imaging (MRI) findings of both superficial and deep juvenile localized scleroderma involvement in children and to evaluate the utility of various MRI sequences for detecting those findings. Two radiologists retrospectively evaluated 20 MRI studies of the extremities in 14 children with juvenile localized scleroderma. Each imaging sequence was also given a subjective score of 0 (not useful), 1 (somewhat useful) or 2 (most useful for detecting the findings). Deep tissue involvement was detected in 65% of the imaged extremities. Fascial thickening and enhancement were seen in 50% of imaged extremities. Axial T1, axial T1 fat-suppressed (FS) contrast-enhanced and axial fluid-sensitive sequences were rated most useful. Fascial thickening and enhancement were the most commonly encountered deep tissue findings in extremity MRIs of children with juvenile localized scleroderma. Because abnormalities of the skin, subcutaneous tissues and fascia tend to run longitudinally in an affected limb, axial T1, axial fluid-sensitive and axial T1-FS contrast-enhanced sequences should be included in the imaging protocol. (orig.)

Musculoskeletal MRI findings of juvenile localized scleroderma.

Science.gov (United States)

Eutsler, Eric P; Horton, Daniel B; Epelman, Monica; Finkel, Terri; Averill, Lauren W

2017-04-01

Juvenile localized scleroderma comprises a group of autoimmune conditions often characterized clinically by an area of skin hardening. In addition to superficial changes in the skin and subcutaneous tissues, juvenile localized scleroderma may involve the deep soft tissues, bones and joints, possibly resulting in functional impairment and pain in addition to cosmetic changes. There is literature documenting the spectrum of findings for deep involvement of localized scleroderma (fascia, muscles, tendons, bones and joints) in adults, but there is limited literature for the condition in children. We aimed to document the spectrum of musculoskeletal magnetic resonance imaging (MRI) findings of both superficial and deep juvenile localized scleroderma involvement in children and to evaluate the utility of various MRI sequences for detecting those findings. Two radiologists retrospectively evaluated 20 MRI studies of the extremities in 14 children with juvenile localized scleroderma. Each imaging sequence was also given a subjective score of 0 (not useful), 1 (somewhat useful) or 2 (most useful for detecting the findings). Deep tissue involvement was detected in 65% of the imaged extremities. Fascial thickening and enhancement were seen in 50% of imaged extremities. Axial T1, axial T1 fat-suppressed (FS) contrast-enhanced and axial fluid-sensitive sequences were rated most useful. Fascial thickening and enhancement were the most commonly encountered deep tissue findings in extremity MRIs of children with juvenile localized scleroderma. Because abnormalities of the skin, subcutaneous tissues and fascia tend to run longitudinally in an affected limb, axial T1, axial fluid-sensitive and axial T1-FS contrast-enhanced sequences should be included in the imaging protocol.

Aminopropyltransferases involved in polyamine biosynthesis localize preferentially in the nucleus of plant cells.

Directory of Open Access Journals (Sweden)

Borja Belda-Palazón

Full Text Available Plant aminopropyltransferases consist of a group of enzymes that transfer aminopropyl groups derived from decarboxylated S-adenosyl-methionine (dcAdoMet or dcSAM to propylamine acceptors to produce polyamines, ubiquitous metabolites with positive charge at physiological pH. Spermidine synthase (SPDS uses putrescine as amino acceptor to form spermidine, whereas spermine synthase (SPMS and thermospermine synthase (TSPMS use spermidine as acceptor to synthesize the isomers spermine and thermospermine respectively. In previous work it was shown that both SPDS1 and SPDS2 can physically interact with SPMS although no data concerning the subcellular localization was reported. Here we study the subcellular localization of these enzymes and their protein dimer complexes with gateway-based Bimolecular Fluorescence Complementation (BiFC binary vectors. In addition, we have characterized the molecular weight of the enzyme complexes by gel filtration chromatography with in vitro assembled recombinant enzymes and with endogenous plant protein extracts. Our data suggest that aminopropyltransferases display a dual subcellular localization both in the cytosol and nuclear enriched fractions, and they assemble preferably as dimers. The BiFC transient expression data suggest that aminopropyltransferase heterodimer complexes take place preferentially inside the nucleus.

'They don't just come for Machu Picchu': locals' views of tourist-local sexual relationships in Cuzco, Peru.

Science.gov (United States)

Bauer, Irmgard

2008-08-01

Sexual and romantic relationships between local people and tourists have long taken place. Such encounters are not a modern phenomenon, but the potential of sexually transmitted infections (STIs), including HIV/AIDS, warrants greater research into the issue. This paper analyses local people's views of local-tourist relationships in Cuzco/Peru. Data were obtained through in-depth interviews, participant and non-participant observation and informal discussions. Attraction based on physical difference was reportedly the main trigger for such relationships. Emerging themes discussed include issues of self-esteem, strategies of approach, tourists' motives, emotional involvement and expectations from such encounters. Levels of unprotected sexual behaviour and lack of STI awareness are of sufficient concern to recommend urgent action. Suggestions for sexual health education are made with particular emphasis on targeting local people involved in the tourism and hospitality industries.

[Xanthoma disseminatum with asymptomatic multisystem involvement].

Science.gov (United States)

Zinoun, M; Hali, F; Marnissi, F; Lazaar, S; Benchikhi, H

2015-04-01

Xanthogranulomas belong to non-Langerhans histiocytosis of the second group in the Histiocyte Society classification. They comprise a heterogeneous group of rare entities frequently involving cutaneous tropism. Xanthoma disseminatum belongs to this group of non-Langerhans histiocytosis. We report a case of xanthoma disseminatum (XD) in which localized skin and mucous impairment revealed multisystem involvement. A 28-year-old man presented with a two-year history of progressive yellow-orange and infiltrated xanthomatous papulonodular lesions of the face. Lesions of the oral mucosa and genital region were seen, with no functional repercussions. No ophthalmic or other complications were found. Histopathology showed a dense histiocytic infiltrate within the dermis with Touton giant cells, foamy multinucleated giant cells and inflammatory cells, without necrobiosis. Histiocytes were positive for CD68 but negative for CD1a. Gastric and lung involvement was seen and was confirmed at histology. Bone scintigraphy showed suspicious left ulnar hyperfixation suggesting bone involvement. No monoclonal gammopathy or diabetes insipidus was seen. Our patient was treated with corticosteroids 1mg/kg/day and thalidomide 100 mg/day. The outcome was marked by regression and exfiltration of the cutaneous lesions from the second week of treatment, with subsidence continuing at 3 months. This case involves a very rare form of xanthoma disseminatum. The localized facial skin lesions revealed multifocal non-Langerhans histiocytosis that was in fact asymptomatic. The diagnosis of XD was based on clinical, histological and immunohistochemical criteria. Xanthoma disseminatum is a non-Langerhans histiocytic proliferation first described by Montgomery in 1938. This rare entity is characterized by skin and mucous membrane xanthomatosis in which the facial involvement is common, together with diabetes insipidus and normal lipid metabolism. The prognosis is determined by the presence of mucosal

Local community involvement in rural tourism development: The case of Kastamonu, Turkey

Directory of Open Access Journals (Sweden)

Bengi Ertuna

2012-01-01

Full Text Available El objetivo de este trabajo es investigar el potencial de los actores locales para el desarrollo de un producto de turismo rural. Un evento tradicional del día de la cosecha fue iniciado por los investi-gadores con este objetivo, y organizado por las partes interesadas de la localidad. Kastamonu, un destino rural de Turquía con gran potencial de desarrollo pero con limitado turismo rural,fue seleccionado para llevar a cabo este evento del día de la cosecha. Se utilizaron la observación y participación de los investigadores, además de entrevistas en profundidad para identifi carlos factores que facilitan la participación de la comunidad local en el desarrollo del producto turístico rural. Losresultados esperan proporcionar información para el desarrollo de un marco de evaluación del potencial de desarrollo sostenible del turismo rural en un área determinada.

Dementia-friendly communities: challenges and strategies for achieving stakeholder involvement.

Science.gov (United States)

Heward, Michelle; Innes, Anthea; Cutler, Clare; Hambidge, Sarah

2017-05-01

Dementia-friendly communities (DFCs) are a UK policy initiative that aims to enable people with dementia to feel supported and included within their local community. Current approaches to DFC creation rely on stakeholder involvement, often requiring volunteer assistance. There is though a lack of evidence that examines the reality of achieving this. This paper critically assesses the challenges and strategies for achieving stakeholder involvement in DFCs. The evidence base is drawn from an inter-agency project funded by the National Health Service in the South of England where seven DFCs were developed by steering group partners and four part-time project workers (PWs). Data from the independent evaluation undertaken in the first year (2013-2014) of the project were analysed: 14 semi-structured interviews and a focus group examined PWs' experiences; while progress and key milestones are determined from monthly progress forms, good news stories, locality steering group minutes and press releases. Analysis was undertaken using a directed content analysis method, whereby data content for each locality was matched to the analytical framework that was drawn from Alzheimer's Society guidance. Challenges to achieving stakeholder involvement were identified as: establishing networks and including people representative of the local community; involving people affected by dementia; and gaining commitment from organisations. Strategies for achieving stakeholder involvement were recognised as: a sustainable approach; spreading the word; and sharing of ideas. By highlighting these challenges and the approaches that have been used within communities to overcome them, these findings form the foundation for the creation of DFC initiatives that will become embedded within communities. Stakeholder involvement is unpredictable and changeable; therefore, reliance on this approach questions the long-term sustainability of DFCs, and must be considered in future policies designed to

The prognostic significance of parapharyngeal tumour involvement in nasopharyngeal carcinoma

International Nuclear Information System (INIS)

Teo, P.Y.; Lee, W.; Yu, P.

1996-01-01

From 1984 to 1989, 903 treatment-naive non-disseminated nasopharyngeal carcinomas (NPCs) were given primary radical radiotherapy. All patients had computed tomographic and endoscopic evaluation of the primary tumour. Potentially significant parameters were analysed by both univariate and multivariate methods for independent significance. In the whole group of patients, the male sex, skull base and cranial nerve(s) involvement, advanced Ho N-level, presence of fixed or partially fixed nodes and nodes contralateral to the side of the bulk of the nasopharyngeal primary, significantly determined survival and distant metastasis rates, whereas skull base and cranial nerve involvement, advanced age and male sex significantly worsened local control. However in the Ho T2No subgroup, parapharyngeal tumour involvement was the most significant prognosticator that determined distant metastasis and survival rates in the absence of the overriding prognosticators of skull base infiltration, cranial nerve(s) palsy, and cervical nodal metastasis. The local tumour control of the Ho T2No was adversely affected by the presence of oropharyngeal tumour extension. The administration of booster radiotherapy (20 Gy) after conventional radiotherapy (60-62.5 Gy) in tumours with parapharyngeal involvement has led to an improvement in local control, short of statistical significance

Learning from games: Stakeholders’ experiences involved in local health policy

DEFF Research Database (Denmark)

Spitters, Hilde; van de Goor, Ien; Juel Lau, Cathrine

2018-01-01

Since public health problems are complex and the related policies need to address a wide range of sectors, cross-sectoral collaboration is beneficial. One intervention focusing on stimulating collaboration is a ‘policy game’. The focus on specific problems facilitates relationships between...... the stakeholders and stimulates cross-sectoral policymaking. The present study explores stakeholders’ learning experiences with respect to the collaboration process in public health policymaking. This was achieved via their game participation, carried out in real-life stakeholder networks in the Netherlands...... the collaboration processes in local policymaking. Specific learning experiences were related to: (i) the stakeholder network, (ii) interaction and (iii) relationships. The game also increased participant’s understanding of group dynamics and need for a coordinator in policymaking. This exploratory study shows...

To renew local energy policies

International Nuclear Information System (INIS)

Bailleul, Esther; Alfano, Patrick; Ballan, Etienne; Bosboeuf, Pascale; Braun, Nicolas; Budin, Jacques-Olivier; Caron, Jean-Francois; Couturier, Christian; Dantec, Ronan; Ducolombier, Alexandre; Durand, Lucas; Haeringer, Nicolas; Izard, Charlotte; Jadot, Yannick; Joos, Marine; Landel, Pierre-Antoine; Le Du, Mathieu; Lucas, Guillaume; Maya, Michel; Moisan, Marie; Peullemeulle, Justine; Pin, Pascaline; Poize, Noemie; Regnier, Yannick; Rudinger, Andreas; Saultier, Patrick; Serne, Pierre; Zeroual, Bouchr; Arevalo, Henri; Bregeon, Anne; Vauquois, Victor; Aussavy, Gregoire

2016-08-01

Presented as a guide, this book proposes an operational and transverse approach to local action in the field of energy. It is illustrated by many field examples which show how actors have been able to (re)gain control of the energy issue. In the first part in which they present the main issues, the authors outline that local authorities are in front line for a European energy transition, recall the French legal framework for local energy transition, describe how to address local energy self-sufficiency, and comment stakes and levers for energy transition financing. The second part deals with action. The authors there describe how to manage a local energy transition, how to act transversally, how to get citizen involved, and how to relate energy transition and local development

The conundrum of police officer-involved homicides: Counter-data in Los Angeles County

Directory of Open Access Journals (Sweden)

Morgan Currie

2016-08-01

Full Text Available This paper draws from critical data studies and related fields to investigate police officer-involved homicide data for Los Angeles County. We frame police officer-involved homicide data as a rhetorical tool that can reify certain assumptions about the world and extend regimes of power. We highlight the possibility that this type of sensitive civic data can be investigated and employed within local communities through creative practice. Community involvement with data can create a countervailing force to powerful dominant narratives and supplement activist projects that hold local officials accountable for their actions. Our analysis examines four Los Angeles County police officer-involved homicide data sets. First, we provide accounts of the semantics, granularity, scale and transparency of this local data. Then, we describe a “counter data action,” an event that invited members of the community to identify the limits and challenges present in police officer-involved homicide data and to propose new methods for deriving meaning from these indicators and statistics.

Local Self-Government as an Architect of Coalitions for Local Development

Directory of Open Access Journals (Sweden)

Anna Gąsior-Niemiec

2014-12-01

Full Text Available The paper addresses the new role played by local self-government units in Poland. Main factors that determine the public authorities’ capacity to become architects of coalitions for local development are identified. Coalitions are defined as partnerships linking and mobilizing stakeholders anchored in three sectors: public, economic and non-governmental. The coalition-making role of the public organs is investigated on the basis of Local Action Groups (LAGs, which are pro-developmental cross-sector organizations established in rural areas of the Podkarpackie (Sub-Carpathian Voivodesh ip, Poland. Findings are presented that draw on quantitative and qualitative results of the research project that investigated mechanisms involved in the operation of the cross-s ector coalitions. The dominant role of the public authorities in those coalitions is demonstrated. The Community-led Local Development model is referred to as the future framework for LAGs.

Empowerment or Impairment? Involving Traditional Communities in School Management

Science.gov (United States)

Mfum-Mensah, Obed

2004-03-01

Community involvement in education has been viewed as a - by no means uncontroversial - means for enabling local members to deepen their participation in the decision-making relevant to their schools by playing a constructive role in the process. On the basis of a study carried out in Ghana, the present contribution to this discussion examines various matters involved in delegating the management of an Alternative Primary Education program to two traditional communities in the north of that country. It also explores how community members, school authorities, the sponsoring non-governmental organization and members of the local management committee themselves perceive such an approach to school management. Issues raised include whether inexperienced and even illiterate local citizens should be allowed to manage their schools, the conflicts which such management often entails and, finally, in what ways it might be beneficially promoted.

A successful local economic development-urban renewal initiative ...

African Journals Online (AJOL)

Despite the urgent need for local economic development in South Africa, Local Economic Development (LED) as area of professional endeavour/activity has largely failed to live up to this need. In this article, an alternative approach to local economic development, which involved a 'bottom-up' approach to urban renewal is ...

mRNA localization mechanisms in Trypanosoma cruzi.

Directory of Open Access Journals (Sweden)

Lysangela R Alves

Full Text Available Asymmetric mRNA localization is a sophisticated tool for regulating and optimizing protein synthesis and maintaining cell polarity. Molecular mechanisms involved in the regulated localization of transcripts are widespread in higher eukaryotes and fungi, but not in protozoa. Trypanosomes are ancient eukaryotes that branched off early in eukaryote evolution. We hypothesized that these organisms would have basic mechanisms of mRNA localization. FISH assays with probes against transcripts coding for proteins with restricted distributions showed a discrete localization of the mRNAs in the cytoplasm. Moreover, cruzipain mRNA was found inside reservosomes suggesting new unexpected functions for this vacuolar organelle. Individual mRNAs were also mobilized to RNA granules in response to nutritional stress. The cytoplasmic distribution of these transcripts changed with cell differentiation, suggesting that localization mechanisms might be involved in the regulation of stage-specific protein expression. Transfection assays with reporter genes showed that, as in higher eukaryotes, 3'UTRs were responsible for guiding mRNAs to their final location. Our results strongly suggest that Trypanosoma cruzi have a core, basic mechanism of mRNA localization. This kind of controlled mRNA transport is ancient, dating back to early eukaryote evolution.

Localization of A11-reactive oligomeric species in prion diseases

DEFF Research Database (Denmark)

Aidt, Frederik H; Hasholt, Lis F; Christiansen, Michael

2013-01-01

To investigate in prion diseases the in-situ localization of prion protein oligomers sharing a common epitope with amyloid oligomers involved in a range of neurodegenerative diseases.......To investigate in prion diseases the in-situ localization of prion protein oligomers sharing a common epitope with amyloid oligomers involved in a range of neurodegenerative diseases....

Local authorities and electricity: territories, actors and issues within the local public service in France

International Nuclear Information System (INIS)

Bouvier, G.

2005-06-01

In France, the role of local authorities in the organization of the electricity supply system is largely unknown mainly due to the size of the state-owned utility Electricite de France (EDF). Local authorities and their groupings played a major role in the electrification of the national territory and have kept important prerogatives as conceding authorities of this service of general interest. These groupings also became the tools of the soft power of local actors. The geopolitical analysis of the relationships between local municipalities and electric power stakeholders shows the diversity of actors and opinions. Stuck between market liberalization issues and decentralization to local authorities, these groupings tend to reinforce their competencies. Furthermore, decentralization goes along with a reinforcement of the political involvement in local energy policy and with conflicts on the adequate territorial scale for theses policies. (author)

Public involvement in environmental, safety and health issues at the DOE Nuclear Weapons Complex

International Nuclear Information System (INIS)

Taylor, Laura L.; Morgan, Robert P.

1992-01-01

The state of public involvement in environmental, safety, and health issues at the DOE Nuclear Weapons Complex is assessed through identification of existing opportunities for public involvement and through interviews with representatives of ten local citizen groups active in these issues at weapons facilities in their communities. A framework for analyzing existing means of public involvement is developed. On the whole, opportunities for public involvement are inadequate. Provisions for public involvement are lacking in several key stages of the decision-making process. Consequently, adversarial means of public involvement have generally been more effective than cooperative means in motivating change in the Weapons Complex. Citizen advisory boards, both on the local and national level, may provide a means of improving public involvement in Weapons Complex issues. (author)

Significcance of cranial nerve involvement shown by the prognosis of nasopharyngeal carcinoma

International Nuclear Information System (INIS)

Hui Zhouguang; Gao Li; Yi Junlin; Li Suyan; Jin Jing; Huang Xiaodong; Luo Jingwei; Xu Guozhen

2006-01-01

Objective: To analyze the cranial nerve involvement in nasophryngeal carcinoma and its relationship with the prognosis with the optimal treatment for such patients studied also. Methods: 935 untreated nasopharyngeal carcinoma patients, admitted into our hospital from January 1990 to June 1999, were analyzed retrospectively. These patients were divided into cranial nerve involved group and cranial nerve un- involved group by patients symptoms signs and/or images before the treatment. SPSS10.0 soft package was used to analyze the effect of cranial nerve involvement on the prognosis. Results: The overall percentage of cranial nerve involvement was 20.0%, of which the trigeminal nerve was most common . The 5-year local recurrence rate was 20.1% and 16.8% (P=0.465) in cranial nerve involved group and un-involved group, respectively. In the patients with cranial nerve involved, the 5-year local recurrence rates of patients who received boost skull base irradiation dose <70, 70-79 and ≥80 Gy was 38.1%, 24.5% and 16.0% (P =0.082), respectively. The 5-year distant metastasis rate was 31.6% and 19.5% (P=0.020) in cranial nerve involved group and un-involved group. The corresponding overall survival rates and disease-free survival rate was 62.2% and 78.1% (P=O.000) and 43.2%, 62.4% (P=0.000), respectively. By multivariate analysis, cranial nerve involvement was an independent factor both in overall survival (RR 1.62, P=0.001 ) and disease-free survival (RR=1.40, P=0.020). Conclusions: There are more distant metastasis, worse overall survival and disease-free survival in patients with cranial nerve involved. Boost irradiation to the involved skull base may improve the local control. Radiotherapy combined with chemotherapy for these patients may also have brighter future. (authors)

Local authorities and electricity: territories, actors and issues within the local public service in France; Les collectivites locales et l'electricite. Territoires, acteurs et enjeux autour du service public local de l'electricite en france

Energy Technology Data Exchange (ETDEWEB)

Bouvier, G

2005-06-15

In France, the role of local authorities in the organization of the electricity supply system is largely unknown mainly due to the size of the state-owned utility Electricite de France (EDF). Local authorities and their groupings played a major role in the electrification of the national territory and have kept important prerogatives as conceding authorities of this service of general interest. These groupings also became the tools of the soft power of local actors. The geopolitical analysis of the relationships between local municipalities and electric power stakeholders shows the diversity of actors and opinions. Stuck between market liberalization issues and decentralization to local authorities, these groupings tend to reinforce their competencies. Furthermore, decentralization goes along with a reinforcement of the political involvement in local energy policy and with conflicts on the adequate territorial scale for theses policies. (author)

Local realism and the Bell inequality

International Nuclear Information System (INIS)

Brody, T.A.

1989-01-01

The Bell inequality has generally been interpreted to involve two requirements for its validity: a locality condition and the existence of hidden variables. The Bell inequality could only be satisfied within the framework of a non-local theory. The Pauli exclusion principle bears an evident non-local character, the origins and implications of which cannot be said to be fully understood; nevertheless, it has not given rise to the conceptual confusions that followed in the wake of the Bell inequality. (Author)

RNA Localization in Astrocytes

DEFF Research Database (Denmark)

Thomsen, Rune

2012-01-01

, regulation of the blood brain barrier and glial scar tissue formation. Despite the involvement in various CNS functions only a limited number of studies have addressed mRNA localization in astrocytes. This PhD project was initially focused on developing and implementing methods that could be used to asses mRNA......Messenger RNA (mRNA) localization is a mechanism by which polarized cells can regulate protein synthesis to specific subcellular compartments in a spatial and temporal manner, and plays a pivotal role in multiple physiological processes from embryonic development to cell differentiation...... localization in astrocyte protrusions, and following look into the subcellular localization pattern of specific mRNA species of both primary astrocytes isolated from cortical hemispheres of newborn mice, and the mouse astrocyte cell line, C8S. The Boyden chamber cell fractionation assay was optimized, in a way...

Oleotourism: Local Actors for Local Tourism Development

Directory of Open Access Journals (Sweden)

Marco Tregua

2018-05-01

Full Text Available Olive oil consumption has grown substantially in recent years, due in part to the fact that olive oil is healthy. Much of the global olive oil production comes from the rural areas of Jaén in southern Spain. Surrounding this industry, services such as oleotourism are increasing. This paper aims to identify the key elements supporting the development of oleotourism. After a preliminary exploratory analysis of the existing data, a qualitative analysis was performed with actors directly involved in the industry in Jaén. The results helped us define the level of the stakeholders’ involvement and the sustainability, the opportunities, and the constraints affecting oleotourism in this area. The practical implications of this investigation can be useful for governing agencies, local firms, and the tourism industry in support of oleotourism development.

Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study

Science.gov (United States)

Chen, Ming; Bao, Yong; Ma, Hong-Lian; Wang, Jin; Wang, Yan; Peng, Fang; Zhou, Qi-Chao; Xie, Cong-Hua

2013-01-01

This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that higher dose could be delivered in IFRT arm than that in ENI arm, and IFRT did not increase the risk of initially uninvolved or isolated nodal failures. Both a tendency of improved locoregional progression-free survival and a significant increased overall survival rate are in favor of IFRT arm in this study. PMID:23762840

Being young and urban: changing patterns of youth involvement in local environmental action in Lima, Peru

NARCIS (Netherlands)

Hordijk, M.

2013-01-01

This article discusses youth engagement in local environmental action in a peripheral settlement in Lima, Peru. Urban local environmental action is analysed in terms of the so-called "brown agenda", covering issues as the provision of drinking water and sanitation, waste collection, the paving of

Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts.

Directory of Open Access Journals (Sweden)

Catalina Perello

Full Text Available Plastidial isoprenoids are a diverse group of metabolites with roles in photosynthesis, growth regulation, and interaction with the environment. The methylerythritol 4-phosphate (MEP pathway produces the metabolic precursors of all types of plastidial isoprenoids. Proteomics studies in Arabidopsis thaliana have shown that all the enzymes of the MEP pathway are localized in the plastid stroma. However, immunoblot analysis of chloroplast subfractions showed that the first two enzymes of the pathway, deoxyxylulose 5-phosphate synthase (DXS and reductoisomerase (DXR, can also be found in non-stromal fractions. Both transient and stable expression of GFP-tagged DXS and DXR proteins confirmed the presence of the fusion proteins in distinct subplastidial compartments. In particular, DXR-GFP was found to accumulate in relatively large vesicles that could eventually be released from chloroplasts, presumably to be degraded by an autophagy-independent process. Together, we propose that protein-specific mechanisms control the localization and turnover of the first two enzymes of the MEP pathway in Arabidopsis chloroplasts.

[Prognostic influence of cutaneous involvement in malignant tumors of the oral cavity].

Science.gov (United States)

Tankéré, F; Camproux, A; Barry, B; Guedon, C; Depondt, J; Gehanno, P

2000-03-01

The aim of this study was to assess the prognostic influence of cutaneous involvement in T4 squamous cell carcinoma of the oral cavity. The population was a homogeneous group of 137 patients. Cutaneous tumor localizations were observed in 20 of them. Surgery and radiotherapy were given in 103 cases and salvage surgery was performed in 34. Local control at 5 years was achieved in 68.5 % of the patients. Carcinologic failure rate was 55 % and 27.3 % in patients with and without cutaneous involvement respectively (p =0. 013). 5-year survivor rate was also correlated with cutaneous involvement: 10 % versus 32.2 % (p <0.0001).

The Globe. Neighbourhood Agenda 21: Going Local in Reading.

Science.gov (United States)

Welsh, Richard

1994-01-01

Reports on the philosophy underlying a project to promote local community involvement in neighborhood plans as a basis for a citywide Local Agenda 21 and the first stages of Go Local on a Better Environment (GLOBE) introduced to give the project a popular identify and communicate the environmental message. (LZ)

Local authorities and electricity: territories, actors and issues within the local public service in France; Les collectivites locales et l'electricite. Territoires, acteurs et enjeux autour du service public local de l'electricite en france

Energy Technology Data Exchange (ETDEWEB)

Bouvier, G

2005-06-15

In France, the role of local authorities in the organization of the electricity supply system is largely unknown mainly due to the size of the state-owned utility Electricite de France (EDF). Local authorities and their groupings played a major role in the electrification of the national territory and have kept important prerogatives as conceding authorities of this service of general interest. These groupings also became the tools of the soft power of local actors. The geopolitical analysis of the relationships between local municipalities and electric power stakeholders shows the diversity of actors and opinions. Stuck between market liberalization issues and decentralization to local authorities, these groupings tend to reinforce their competencies. Furthermore, decentralization goes along with a reinforcement of the political involvement in local energy policy and with conflicts on the adequate territorial scale for theses policies. (author)

Localized scleroderma and regional inflammatory myopathy.

Science.gov (United States)

Zivković, Saša A; Freiberg, William; Lacomis, David; Domsic, Robyn T; Medsger, Thomas A

2014-05-01

Inflammatory myopathy is rare in localized scleroderma. We report 2 new cases of regional inflammatory myopathy associated with localized scleroderma and review 10 reported cases of localized scleroderma associated with an inflammatory myopathy with regional muscle involvement, more often in the upper extremities. Serum creatine kinase was mildly elevated or normal. Histopathology often showed perimysial inflammation and plasma cell infiltration. These cases demonstrate that inflammatory myopathy should be considered in patients with localized scleroderma and regional muscle weakness, pain or atrophy. Muscle biopsy can confirm the diagnosis of myositis, which if identified, will require anti-inflammatory and/or immunosuppressive therapy. Published by Elsevier B.V.

[Initial subretinal localization of acute myeloblastic leukemia (AML5) recurrence].

Science.gov (United States)

Le Gall, S; François, S; Urier, N; Genevieve, F; d'Hermies, F; Rachieru, P; Ifrah, N

2001-10-13

Reduced visual acuity in patients with acute leucemia can result from many causes including an ocular localization. A patient previously treated for acute myeloblastic leucemia-5 (AML5) developed bilateral vision impairment related to a subretinal localization of the leucemia. Meningeal and bone marrow relapse followed. The subretinal localization responded only to massive systemic steroid treatment. Although asymptomatic, ocular localizations are frequent in leucemia. Their prognostic impact depends on the ocular structure involved and on the chronology of onset--early or late in the leucemia course. The underlying pathophysiological mechanism of ocular involvement remains unexplained but hyperleucocytosis at presentation may be a risk factor and would justify at least systematic specialized examinations and discussion of prophylactic treatment.

Consuming nostalgia? The appreciation of authenticity in local food production

NARCIS (Netherlands)

Autio, M.; Collins, R.; Wahlen, S.; Anttila, M.

2013-01-01

Many consumers consider local food a more sustainable choice than conventional food because of the shorter transport distances involved as well as the support provided to local economies. In addition, consumers value the perceived safety benefits, ethical associations and improved taste of local

Public involvement in environmental surveillance at Hanford

International Nuclear Information System (INIS)

Hanf, R.W. Jr.; Patton, G.W.; Woodruff, R.K.; Poston, T.M.

1994-08-01

Environmental surveillance at the Hanford Site began during the mid-1940s following the construction and start-up of the nation's first plutonium production reactor. Over the past approximately 45 years, surveillance operations on and off the Site have continued, with virtually all sampling being conducted by Hanford Site workers. Recently, the US Department of Energy Richland Operations Office directed that public involvement in Hanford environmental surveillance operations be initiated. Accordingly, three special radiological air monitoring stations were constructed offsite, near hanford's perimeter. Each station is managed and operated by two local school teaches. These three stations are the beginning of a community-operated environmental surveillance program that will ultimately involve the public in most surveillance operations around the Site. The program was designed to stimulate interest in Hanford environmental surveillance operations, and to help the public better understand surveillance results. The program has also been used to enhance educational opportunities at local schools

Extent and patterns of community collaboration in local health departments: An exploratory survey

Directory of Open Access Journals (Sweden)

Fisher John W

2011-10-01

Full Text Available Abstract Background Local public health departments (LHDs in the United States have been encouraged to collaborate with various other community organizations and individuals. Current research suggests that many forms of active partnering are ongoing, and there are numerous examples of LHD collaboration with a specific organization for a specific purpose or program. However, no existing research has attempted to characterize collaboration, for the defined purpose of setting community health status priorities, between a defined population of local officials and a defined group of alternative partnering organizations. The specific aims of this study were to 1 determine the range of collaborative involvement exhibited by a study population of local public health officials, and, 2 characterize the patterns of the selection of organizations/individuals involved with LHDs in the process of setting community health status priorities. Methods Local health department officials in North Carolina (n = 53 responded to an exploratory survey about their levels of involvement with eight types of possible collaborator organizations and individuals. Descriptive statistics and the stochastic clustering technique of Self-Organizing Maps (SOM were used to characterize their collaboration. Results Local health officials vary extensively in their level of collaboration with external collaborators. While the range of total involvement varies, the patterns of involvement for this specific function are relatively uniform. That is, regardless of the total level of involvement (low, medium or high, officials maintain similar hierarchical preference rankings with Community Advisory Boards and Local Boards of Health most involved and Experts and Elected Officials least involved. Conclusion The extent and patterns of collaboration among LHDs with other community stakeholders for a specific function can be described and ultimately related to outcome measures of LHD performance.

Involving Extension in Urban Food Systems: An Example from California

Directory of Open Access Journals (Sweden)

Lucy Diekmann

2017-06-01

Full Text Available Nationwide, Extension is increasingly involved in local food system work. In cities, initiatives to improve the local food system often include urban agriculture, which has attracted the attention of diverse stakeholders for its many potential social, health, economic, and environmental impacts. This article illustrates how Extension in the San Francisco Bay Area is developing urban agriculture programming and engaging in food-system-related partnerships. It also shares lessons learned from these efforts. In this metropolitan region, Extension practice aligns well with research findings on Extension involvement in local food systems, particularly with the emphasis on providing educational opportunities and resources adapted to unique needs of city residents and working collaboratively with community and government partners to facilitate broader food system change. The results of this case study will be useful for Extension personnel in designing and implementing programs related to urban food systems.

[Localized scleroderma (morphea)].

Science.gov (United States)

Bono, Waafa; Dupin, Nicolas

2006-12-01

DEFINITION AND FREQUENCY: Localized scleroderma, also known as morphea, is a sclerotic condition limited to the skin. The specific clinical entity depends on the extent, linear disposition and depth of the lesions. Morphea is ten times more prevalent than systemic sclerosis, and its prognosis is generally good: superficial forms resolve within 3 years. In the absence of symptoms, examinations to detect systemic involvement are purposeless. Plaque morphea is the most frequent clinical presentation. Serious manifestations include extensive morphea that may involve the entire skin or linear forms, especially in children, where they may be severe, especially on the face. There are no immunological markers clearly associated with morphea and no causative agents have been implicated in its pathogenesis, although sclerodermiform dermatitis is reported to be associated with some drugs and toxic agents. There is no consensual treatment for morphea. Treatment should be decided according to severity and extent of lesions. Limited lesions may be treated with local steroids such as class IV corticosteroids. Systemic treatment (methotrexate) should be discussed in extensive and linear forms when there is a risk of functional or esthetic complications.

Purely non-local Hamiltonian formalism, Kohno connections and ∨-systems

International Nuclear Information System (INIS)

Arsie, Alessandro; Lorenzoni, Paolo

2014-01-01

In this paper, we extend purely non-local Hamiltonian formalism to a class of Riemannian F-manifolds, without assumptions on the semisimplicity of the product ○ or on the flatness of the connection ∇. In the flat case, we show that the recurrence relations for the principal hierarchy can be re-interpreted using a local and purely non-local Hamiltonian operators and in this case they split into two Lenard-Magri chains, one involving the even terms, the other involving the odd terms. Furthermore, we give an elementary proof that the Kohno property and the ∨-system condition are equivalent under suitable assumptions and we show how to associate a purely non-local Hamiltonian structure to any ∨-system, including degenerate ones

Intensity-Modulated Proton Therapy for Elective Nodal Irradiation and Involved-Field Radiation in the Definitive Treatment of Locally Advanced Non-Small Cell Lung Cancer: A Dosimetric Study

Science.gov (United States)

Kesarwala, Aparna H.; Ko, Christine J.; Ning, Holly; Xanthopoulos, Eric; Haglund, Karl E.; O’Meara, William P.; Simone, Charles B.; Rengan, Ramesh

2015-01-01

Background Photon involved-field radiation therapy (IFRT), the standard for locally advanced non-small cell lung cancer (LA-NSCLC), results in favorable outcomes without increased isolated nodal failures, perhaps from scattered dose to elective nodal stations. Given the high conformality of intensity-modulated proton therapy (IMPT), proton IFRT could increase nodal failures. We investigated the feasibility of IMPT for elective nodal irradiation (ENI) in LA-NSCLC. Materials and Methods IMPT IFRT plans were generated to the same total dose of 66.6–72 Gy received by 20 LA-NSCLC patients treated with photon IFRT. IMPT ENI plans were generated to 46 CGE to elective nodal (EN) planning treatment volumes (PTV) plus 24 CGE to involved field (IF)-PTVs. Results Proton IFRT and ENI both improved D95 involved field (IF)-PTV coverage by 4% (pENI. Mean esophagus dose decreased 16% with IFRT and 12% with ENI; heart V25 decreased 63% with both (all pENI. Potential decreased toxicity indicates IMPT could allow ENI while maintaining a favorable therapeutic ratio compared to photon IFRT. PMID:25604729

Geological disposal of radioactive waste: national commitment, local and regional involvement - A Collective Statement of the OECD Nuclear Energy Agency Radioactive Waste Management Committee Adopted March 2012

International Nuclear Information System (INIS)

2012-01-01

Disposal in engineered facilities built in stable, deep geological formations is the reference solution for permanently isolating long-lived radioactive waste from the human biosphere. This management method is designed to be intrinsically safe and final, meaning that it is not dependent on human presence or intervention in order to fulfil its safety goal. Selecting the site of a waste repository brings up a range of issues involving scientific knowledge, technical capacity, ethical values, territorial planning, community well-being and more. Bringing to fruition the multi-decade task of siting and developing a repository demands a strong national commitment and significant regional and local involvement. This collective statement by the Radioactive Waste Management Committee of the OECD Nuclear Energy Agency recognises the advances made towards greater transparency and dialogue among the diverse stakeholders concerned and identifies the fundamental elements needed to support national commitment and to foster territorial involvement. It concludes that technical and societal partners can develop shared confidence in the safety of geological repositories and jointly carry these projects forward [fr

A successful effort to involve stakeholders in a facility siting decision using LIPS with stakeholder involvement

International Nuclear Information System (INIS)

Merkhofer, L.; Conway, R.; Anderson, B.

1995-01-01

Local public opposition to federal bureaucratic decisions has resulted in public agencies rethinking the role of stakeholders in decision making. Efforts to include stakeholders directly in the decision-making process are on the increase. Unfortunately, many attempts to involve members of the public in decisions involving complex technical issues have failed. A key problem has been defining a meaningful role for the public in the process of arriving at a technical decision. This paper describes a successful effort by Sandia National Laboratories (SNL) in New Mexico to involve stakeholders in an important technical decision associated with its Environmental Restoration (ER) Project. The decision was where to locate a Corrective Action Management Unit (CAMU), a facility intended to consolidate and store wastes generated from the cleanup of hazardous waste sites. A formal priority setting process known as the Laboratory Integration Prioritization System (LIPS) was adapted to provide an approach for involving the public. Although rarely applied to stakeholder participation, the LIPS process proved surprisingly effective. It produced a consensus over a selected site and enhanced public trust and understanding of Project activities

Local Currency Financing--The Next Frontier for MDBs?

OpenAIRE

Hoschka, Tobias C.

2005-01-01

This paper surveys the issues involved in local currency financing by multilateral development banks (MDBs). While MDBs have traditionally provided financing in foreign currency to their borrowers, greater sensitivity by borrowers to potential currency mismatches, political decentralization, and the development of local capital markets have recently led MDBs to consider providing financing in local currency. While still small in comparison to MDBs' foreign currency financing, this paper argue...

Local investment in renewable energies; Investissement local dans les Energies Renouvelables

Energy Technology Data Exchange (ETDEWEB)

Grepmeier, K; Larsen, J; Manolakaki, E; Quantin, J; Twele, J

2003-07-01

This document presents european examples on the interest of the local investment, illustrated by cases studies in Germany, Denmark and Switzerland. Two main points were discussed: the financial tools and the french strategy. The colloquium provided many discussions and analyzes on the possibility of significant contribution to the collective efforts in favor of the public involvement in the renewable energies development in Europe. (A.L.B.)

How often parametrial involvement leads to post-operative adjuvant treatment in locally advanced cervical cancer after neoadjuvant chemotherapy and type C radical hysterectomy?

Science.gov (United States)

Martinelli, F; Bogani, G; Ditto, A; Carcangiu, M; Papadia, A; Lecce, F; Chiappa, V; Lorusso, D; Raspagliesi, F

2015-08-01

Parametrial involvement (PMI) is one of the most important factors influencing prognosis in locally advanced stage cervical cancer (LACC) patients. We aimed to evaluate PMI rate among LACC patients undergoing neoadjuvant chemotherapy (NACT), thus evaluating the utility of parametrectomy in tailor adjuvant treatments. Retrospective evaluation of consecutive 275 patients affected by LACC (IB2-IIB), undergoing NACT followed by type C/class III radical hysterectomy. Basic descriptive statistics, univariate and multivariate analyses were applied in order to identify factors predicting PMI. Survival outcomes were assessed using Kaplan-Meier and Cox models. PMI was detected in 37 (13%) patients: it was associated with vaginal involvement, lymph node positivity and both in 10 (4%), 5 (2%) and 12 (4%) patients, respectively; while PMI alone was observed in only 10 (4%) patients. Among this latter group, adjuvant treatment was delivered in 3 (1%) patients on the basis of pure PMI; while the remaining patients had other characteristics driving adjuvant treatment. Considering factors predicting PMI we observed that only suboptimal pathological responses (OR: 1.11; 95% CI: 1.01, 1.22) and vaginal involvement (OR: 1.29 (95%) CI: 1.17, 1.44) were independently associated with PMI. PMI did not correlate with survival (HR: 2.0; 95% CI: 0.82, 4.89); while clinical response to NACT (HR: 3.35; 95% CI: 1.59, 7.04), vaginal involvement (HR: 2.38; 95% CI: 1.12, 5.02) and lymph nodes positivity (HR: 3.47; 95% CI: 1.62, 7.41), independently correlated with worse survival outcomes. Our data suggest that PMI had a limited role on the choice to administer adjuvant treatment, thus supporting the potential embrace of less radical surgery in LACC patients undergoing NACT. Further prospective studies are warranted. Copyright © 2015 Elsevier Ltd. All rights reserved.

Local climate activities in co-operation between municipality, civil society and science shop

DEFF Research Database (Denmark)

Jørgensen, Michael Søgaard

The Science Shop at DTU co-operates with the local municipal administration and the local branch of an environmental NGO about climate change. The co-operation was initiated by a proposal to the Science Shop from the municipal administration. Since the Science Shop requests civil society...... involvement in projects it was proposed to involve the local branch of the environmental NGO. The starting point was topics developed by the administration and the NGO together and announced to students as part of the Science Shop project supply. The focus is climate impact of local activities and strategies...... are initiated and co-ordinated by a group with members from municipal administration, the local NGO and the Science Shop. All projects have involved student projects, but most projects have also contributed to ongoing research activities. The projects up till now have focused on the municipal food supply...

The local interstellar medium and gamma-ray astronomy

International Nuclear Information System (INIS)

Lebrun, F.; Paul, J.

1985-08-01

The recent improvement of the calibration of the galaxy counts used as an interstellar-absorption tracer modifies significantly the picture of the local interstellar medium (ISM). Consequently, previous analyses of the γ-ray emission from the local ISM involving galaxy counts have to be revised. In this paper, we consider the implications regarding the cosmic-ray (CR) density in the local ISM, and in particular within Loop I, a nearby supernova remnant (SNR)

Local thermodynamic equilibrium and related metrological issues involving collisional-radiative model in laser-induced aluminum plasmas

International Nuclear Information System (INIS)

Travaille, G.; Peyrusse, O.; Bousquet, B.; Canioni, L.; Pierres, K. Michel-Le; Roy, S.

2009-01-01

We present a collisional-radiative approach of the theoretical analysis of laser-induced breakdown spectroscopy (LIBS) plasmas. This model, which relies on an optimized effective potential atomic structure code, was used to simulate a pure aluminum plasma. The description of aluminum involved a set of 220 atomic levels representative of three different stages of ionization (Al 0 , Al + and Al ++ ). The calculations were carried for stationary plasmas, with input parameters (n e and T e ) ranging respectively between 10 13-18 cm -3 and 0.3-2 eV. A comparison of our atomic data with some existing databases is made. The code was mainly developed to address the validity of the local thermodynamic equilibrium (LTE) assumption. For usual LIBS plasma parameters, we did not reveal a sizeable discrepancy of the radiative equilibrium of the plasma towards LTE. For cases where LTE was firmly believed to stand, the Boltzmann plot outputs of this code were used to check the physical accuracy of the Boltzmann temperature, as it is currently exploited in several calibration-free laser-induced breakdown spectroscopy (CF-LIBS) studies. In this paper, a deviation ranging between 10 and 30% of the measured Boltzmann temperature to the real excitation temperature is reported. This may be due to the huge dispersion induced on the line emissivities, on which the Boltzmann plots are based to extract this parameter. Consequences of this fact on the CF-LIBS procedure are discussed and further insights to be considered for the future are introduced.

Internal Guidelines for interactions with communities and local governments

International Nuclear Information System (INIS)

1985-11-01

These Guidelines provide principles for interactions with local populations. Interaction with communities and local govenments are the responsibility of the Office of Civilian Radioactive Wastes Management program's implementing offices. The Guidelines provide policy direction to these implementing offices, while preserving their ability to tailor local interactions to fit a given situation, taking into account the social and political context and the history of local involvement in the program. Project Offices conduct community and local interactions within overall program resources which must be husbanded prudently. Careful planning by implementing offices should ensure that adequate resources are available to foster effective interactions with local representatives

Radiographic localization of unerupted teeth: further findings about the vertical tube shift method and other localization techniques.

Science.gov (United States)

Jacobs, S G

2000-10-01

The parallax method (image/tube shift method, Clark's rule, Richards' buccal object rule) is recommended to localize unerupted teeth. Richards' contribution to the development of the parallax method is discussed. The favored method for localization uses a rotational panoramic radiograph in combination with an occlusal radiograph involving a vertical shift of the x-ray tube. The use of this combination when localizing teeth and supernumeraries in the premolar region is illustrated. When taking an occlusal radiograph to localize an unerupted maxillary canine, clinical situations are presented where modification of the vertical angulation of the tube of 70 degrees to 75 degrees or of the horizontal position of the tube is warranted. The limitations of axial (true, cross-sectional, vertex) occlusal radiographs are also explored.

Unravelling networks in local public health policymaking in three European countries

DEFF Research Database (Denmark)

Spitters, Hilde P.E.M.; Lau, Cathrine J; Sandu, Petru

2017-01-01

the main stakeholders involved and their position and relations in the policymaking process. The Netherlands and Denmark were the most similar and both differed most from Romania, especially at the level of accountability of the local public authorities for local HEPA policymaking. The categories...... of these European country cases. Methods: A systems analysis of the local HEPA policymaking process was performed in three European countries involved in the 'REsearch into POlicy to enhance Physical Activity' (REPOPA) project, resulting in three schematic models showing the main stakeholders...... of driving forces underlying the relations between stakeholders were formal relations, informal interaction and knowledge exchange. Conclusions: A systems analysis providing detailed descriptions of positions and relations in the stakeholder network in local level HEPA policymaking is rather unique...

Developing Exchange in Short Local Foods Supply Chains

Directory of Open Access Journals (Sweden)

Per Engelseth

2016-07-01

Full Text Available The supply chain management of foods is commonly associated with modernistic large-scale production. This involves long transport distances of foods to reach consumers. In the case of local foods, supply chains are shorter. Based on a case study of five local foods producer's supply of their products to a common retailer, the supply chain of local foods is modelled conceptually and modes of development are pointed out based on contingency theory and supply chain management literature. Findings reveal that since these chains are transparent, reciprocal interdependency is abundant mainly because human perception creates a sufficient understanding of the operations management issues pertinent within this simple inter-organisational structure. Local foods supply chains are similar to service supply chains. This includes that both are short in nature and associated with bi-directional interaction between the customer and supplier. Developing short supply chains in local foods supply is associated with improving the exchange economy found in short supply chains. This also implies that development of local foods supply is associated with two paths which may be complementary. First, the use of improved intensive technology associated with reciprocal interdependency to develop efficiencies in the bi-directional and somewhat complex interaction. Alternatively local foods suppliers may seek to reduce this form of reciprocal interdependency thereby increasing the impact of pooled interdependencies and enabling using mediating technology involving standardising interaction such as through increased standardised products and packaging as well as automation of information connectivity.

[Symptoms. Localizations: knee, hip, hands, spine, other localizations].

Science.gov (United States)

Pérez Martín, Álvaro

2014-01-01

The symptoms of osteoarthritis vary widely from patient to patient, depending especially on the localization on the disease. There is a poor correlation between radiological involvement and pain. In general, symptom onset is gradual and symptoms increase slowly but progressively. The most commonly affected joints are the knees, hips, hands, and spine. The main signs and symptoms are pain, stiffness, joint deformity, and crepitus. Pain is mechanical and its causes are multifactorial; in the initial phases, pain usually manifests in self-limiting episodes but may subsequently be almost constant. The criteria of the American college of Rheumatology for the classification of osteoarthritis of the knee, hip and hands are an aid to classification and standardization but are not useful for diagnosis. Hip osteoarthritis usually produces inguinal pain in the internal and anterior sections of the muscle extending to the knee and, with progression, tends to limit mobility. Knee osteoarthritis is more frequent in women and is usually associated with hand osteoarthritis and obesity. In hand osteoarthritis, the most commonly affected joints are the distal interphalangeal joints, followed by the proximal interphalangeal joints and the trapeziometacarpal joints; the development of Heberden and Bouchard nodes is common; involvement of the trapeziometacarpal joint is called rhizarthrosis and is one of the forms of osteoarthritis that produces the greatest limitation on hand function. Osteoarthritis of the spine affects the facet joints and the vertebral bodies. Other, less frequent, localizations are the foot, elbow and shoulder, which are generally secondary forms of osteoarthritis. Copyright © 2014 Elsevier España, S.L. All rights reserved.

Silent Localization of Underwater Sensors Using Magnetometers

Directory of Open Access Journals (Sweden)

Jonas Callmer

2010-01-01

Full Text Available Sensor localization is a central problem for sensor networks. If the sensor positions are uncertain, the target tracking ability of the sensor network is reduced. Sensor localization in underwater environments is traditionally addressed using acoustic range measurements involving known anchor or surface nodes. We explore the usage of triaxial magnetometers and a friendly vessel with known magnetic dipole to silently localize the sensors. The ferromagnetic field created by the dipole is measured by the magnetometers and is used to localize the sensors. The trajectory of the vessel and the sensor positions are estimated simultaneously using an Extended Kalman Filter (EKF. Simulations show that the sensors can be accurately positioned using magnetometers.

Communication in Local Community (Koprivnica case study

Directory of Open Access Journals (Sweden)

Melita Pavlek

2014-09-01

Full Text Available It is about an article which, based on the research of the local media in Koprivnica, aims to question the current theoretical attitutes to the role of the media nowadays, changes in communication, ways of connecting politics and journalism, censorship and self-censorship, bigger involvement of citizens in informing themselves via social networks, as well as other aspects of the media influence on the public. The local media in Koprivnica, among others, published articles about the biggest political and economic scandals in Croatia. At the same time, local media is significantly intertwined with local politics. How much and how are these things related? The number of local journalists with a degree in journalism is not satisfactory. How does the local community cope with it? What has changed three years after the research of three local media in Koprivnica finished? Can the local community i.e. the experience of the local media draw attention to illogical, unacceptable and illegal anomalies that create a negative perception of journalism in Croatia as well as the rest of the world nowadays?

Community involvement in constructing village health buildings in Uganda and Sierra Leone.

Science.gov (United States)

Mitchell, M

1995-11-01

Three public health projects in Uganda and Sierra Leone are used to illustrate a new approach to construction of health buildings in villages. Emphasis is placed on community involvement. The health projects were comprehensive and relied on health education, employment of local village health workers, and establishment of village health committees. The objective of community involvement was described as encouragement of people to change their own diets and living conditions. This approach to primary health care is considered to be a strong basis for sustainable social development. Each of the three communities initiated the building projects slightly differently. There was a range of structures: traditional meeting halls, simple rooms with imported materials and a pit latrine, new buildings combining local and imported materials and labor, new nontraditional buildings, rehabilitated existing nontraditional buildings with imported labor and materials, and temporary mobile clinics. Community involvement was at different levels. All three projects were the result of a combined effort of national governments or mission hospitals, nongovernmental organizations, and the host community. The following should be considered before beginning construction: a suitable site, appropriate staff accommodation, the likely motivation of the host community, seasonality, local materials available, availability of skilled labor, and design. A plan of work during construction should include a building design, site supervision, transportation of local and non-local materials, unskilled labor, and skilled labor. Village health committees with or without government help would be responsible for maintenance of buildings after construction. A key feature of this approach is the assessment of the community's ability and capacity to contribute.

Occurrence of paresthesia after dental local anesthetic administration in the United States.

Science.gov (United States)

Garisto, Gabriella A; Gaffen, Andrew S; Lawrence, Herenia P; Tenenbaum, Howard C; Haas, Daniel A

2010-07-01

Several studies have suggested that the likelihood of paresthesia may depend on the local anesthetic used. The purpose of this study was to determine if the type of local anesthetic administered had any effect on reports of paresthesia in dentistry in the United States. The authors obtained reports of paresthesia involving dental local anesthetics during the period from November 1997 through August 2008 from the U.S. Food and Drug Administration Adverse Event Reporting System. They used chi(2) analysis to compare expected frequencies, on the basis of U.S. local anesthetic sales data, with observed reports of oral paresthesia. During the study period, 248 cases of paresthesia occurring after dental procedures were reported. Most cases (94.5 percent) involved mandibular nerve block. The lingual nerve was affected in 89.0 percent of cases. Reports involving 4 percent prilocaine and 4 percent articaine were 7.3 and 3.6 times, respectively, greater than expected (chi(2), P paresthesia occurs more commonly after use of 4 percent local anesthetic formulations. These findings are consistent with those reported in a number of studies from other countries. Until further research indicates otherwise, dentists should consider these results when assessing the risks and benefits of using 4 percent local anesthetics for mandibular block anesthesia.

Residential Tourism and Multiple Mobilities: Local Citizenship and Community Fragmentation in Costa Rica

Directory of Open Access Journals (Sweden)

Femke van Noorloos

2013-02-01

Full Text Available Current patterns of “move-in move-out” hypermobility are perfectly exemplified by residential tourism: the temporary or permanent mobility of relatively well-to-do citizens from mostly western countries to a variety of tourist destinations, where they buy property. The mobility of residential tourists does not stand alone, but has broader chain effects: it converts local destinations into transnational spaces, leading to a highly differentiated and segmented population landscape. In this article, residential tourism’s implications in terms of local society in Guanacaste, Costa Rica, are examined, starting from the idea that these implications should be viewed as complex and traveling in time and space. Mobile groups, such as residential tourists, can have an important local participation and involvement (independently of national citizenship, although recent flows of migrants settle more into compatriot social networks. The fact that various migrant populations continually travel back and forth and do not envision a future in the area may restrict their opportunities and willingness for local involvement. Transnational involvement in itself is not a problem and can be successfully combined with high local involvement; however, the great level of fragmentation, mobility, temporariness and absenteeism in Guanacaste circumscribes successful community organizing. Still, the social system has not completely dissolved.

Generalized dysplasia epiphysealis hemimelica with contralateral sacro-iliac joint involvement

International Nuclear Information System (INIS)

Karam, Adib R.; Birjawi, Ghina A.; Khoury, Nabil J.; Saghieh, Said; Tawil, Ayman

2008-01-01

Dysplasia epiphysealis hemimelica (or Trevor's disease) is a rare developmental bone dysplasia characterized by benign osteocartilaginous overgrowth involving one or multiple epiphyses, usually of a single lower extremity. It is classified as localized form, classical form (most common), and generalized form. In this report we describe a case of generalized form of dysplasia epiphysealis hemimelica with involvement of the contralateral sacroiliac joint, which is an extremely rare presentation. (orig.)

Generalized dysplasia epiphysealis hemimelica with contralateral sacro-iliac joint involvement

Energy Technology Data Exchange (ETDEWEB)

Karam, Adib R.; Birjawi, Ghina A.; Khoury, Nabil J. [American University of Beirut Medical Center, Department of Diagnostic Radiology, Beirut (Lebanon); Saghieh, Said [American University of Beirut Medical Center, Department of Orthopedic Surgery, Beirut (Lebanon); Tawil, Ayman [American University of Beirut Medical Center, Department of Pathology, Beirut (Lebanon)

2008-12-15

Dysplasia epiphysealis hemimelica (or Trevor's disease) is a rare developmental bone dysplasia characterized by benign osteocartilaginous overgrowth involving one or multiple epiphyses, usually of a single lower extremity. It is classified as localized form, classical form (most common), and generalized form. In this report we describe a case of generalized form of dysplasia epiphysealis hemimelica with involvement of the contralateral sacroiliac joint, which is an extremely rare presentation. (orig.)

Characterization of Carbohydrate Active Enzymes Involved in Arabinogalactan Protein Metabolism

DEFF Research Database (Denmark)

Knoch, Eva

and tissues, their functions and synthesis are still poorly understood. The aim of the research presented in the thesis was to characterize carbohydrate active enzymes involved in AGP biosynthesis and modification to gain insights into the biosynthesis of the glycoproteins in plants. Candidate...... glycosyltransferases and glycoside hydrolases were selected based on co-expression profiles from a transcriptomics analysis. Reverse genetics approach on a novel glucuronosyltransferase involved in AGP biosynthesis has revealed that the enzyme activity is required for normal cell elongation in etiolated seedlings....... The enzymatic activity of a hydrolase from GH family 17 was investigated, without successful determination of the activity. Members of hydrolase family 43 appeared to be localized in the Golgi-apparatus, which is also the compartment for glycan biosynthesis. The localization of these glycoside hydrolases...

The institutional logics of local government budget in Indonesia

Directory of Open Access Journals (Sweden)

Palupi Ade

2017-01-01

Full Text Available This study asks how and why a local government settings budget. It aims to deliver an understanding on how a government entity perceives that budget is important element to manage public expenditures. It uses the S local government in Indonesia as a case study. This study applies Institutional Logics Theory as a theoretical framework in order to analyze data. Data is collected by interviewing seven key persons who directly involves in budgeting process. This research shows that the budgeting process includes determining the purposes of annual budget, setting up planned programs and actvities, determining the amount of revenue that will be collected, allocating resources to expenditures and setting up standar pricing. Some important points in the budgeting process are identified. Those are considering political aspect to determine local tax rate, focusing on competition with other local governments, fulfilling the political promise of local government leader to the constituents, involving community to determine planned program and activities, and allocating resources based on community basic needs. This study concludes that those points develop the institutional logics of politic and managerial in budget setting process.

Local climate protection programmes in Australia and New Zealand

DEFF Research Database (Denmark)

Hoff, Jens Villiam

about climate change broadly in the involved councils/local communities. • The CCP programme gave councils a strong focus, which led to the formulation of a coherent program on climate change, and allowed them to take on a leadership role in the local community. The leadership role was important...... in aligning the agendas of different stakeholders, and in local efforts to achieve attitude- and culture changes towards a more environmentally sustainable local community. • The CCP programme created a network among participating councils for sharing experiences and motivating each other. It also provided...

More about the comparison of local and non-local NN interaction models

International Nuclear Information System (INIS)

Amghar, A.; Desplanques, B.

2003-01-01

The effect of non-locality in the NN interaction with an off-energy shell character has been studied in the past in relation with the possibility that some models could be approximately phase-shifts equivalent. This work is extended to a non-locality implying terms that involve an anticommutator with the operator p 2 . It includes both scalar and tensor components. The most recent 'high accuracy' models are considered in the analysis. After studying the deuteron wave functions, electromagnetic properties of various models are compared with the idea that these ones differ by their non-locality but are equivalent up to a unitary transformation. It is found that the extra non-local tensor interaction considered in this work tends to re-enforce the role of the term considered in previous works, allowing one to explain almost completely the difference in the deuteron D-state probabilities evidenced by the comparison of the Bonn-QB and Paris models for instance. Conclusions for the effect of the non-local scalar interaction are not so clear. In many cases, it was found that these terms could explain part of the differences that the comparison of predictions for various models evidences but cases where they could not were also found. Some of these last ones have been analyzed in order to pointing out the origin of the failure

Continuity of Local Time: An applied perspective

OpenAIRE

Ramirez, Jorge M.; Waymire, Edward C.; Thomann, Enrique A.

2015-01-01

Continuity of local time for Brownian motion ranks among the most notable mathematical results in the theory of stochastic processes. This article addresses its implications from the point of view of applications. In particular an extension of previous results on an explicit role of continuity of (natural) local time is obtained for applications to recent classes of problems in physics, biology and finance involving discontinuities in a dispersion coefficient. The main theorem and its corolla...

Analysis of Local Economic Development Capacity in Hungarian Rural Settlements

Directory of Open Access Journals (Sweden)

Ritter Krisztián

2017-11-01

Full Text Available Besides local economic development (LED theories, especially LED practices have a growing importance nowadays. By a primary research involving more than 400 actors (local governments, local entrepreneurs, local agencies, the necessary competencies, practical experiences, and the field of further skills and extension concerning cooperation in economic development of localities were analysed. Summing up the research results, both local governments and local entrepreneurs have certain lack of competence that has to be improved, while the need of this exercise (and LED as a whole for an appropriate financial background and a national strategy/policy is well-emphasized by the answers of the actors.

Localization of nuclear power plant technology

International Nuclear Information System (INIS)

Stiteler, F.Z.; Rudek, T.G.

1998-01-01

Asia, and particularly China, has an enormous need for power and must deal with the practicalities of building large base load units. In China, as in other countries, there are limitations on the use of large quantities of fossil fuel. This raises the possibility of turning to nuclear power to satisfy their energy needs. Other issues tend to point to the nuclear option for these growing economies, including economic considerations, environmental concerns, energy independence and raising the technological capabilities of the country. When a country embarks on a nuclear power program with the intention of localizing the technology, a long-term commitment is necessary to achieve this objective. Localization of nuclear technology is not a new phenomenon. The nature of the industry from the early beginnings has always involved transfer of technology when a new country initiated a nuclear power construction program. In fact, most previous experiences with this localization process involved heavy governmental, political and financial support to drive the success of the program. Because of this strong governmental support, only the receiving nation's companies were generally allowed to participate in the local business operations of the technology recipient. What is new and different today is the retreat from heavy financial support by the receiving country's government. This change has created a strong emphasis on cost-effectiveness in the technology transfer process and opportunities for foreign companies to participate in local business activities. ABB is a world-wide company with two parent companies that have been very active over many years in establishing cost-justified local operations throughout the world. Today, ABB has become the largest electrical engineering company in the world with respected local operations in nearly every country. Lessons learned by ABB in their world-wide localization initiatives are being applied to the challenge of cost

Neuronal involvement in cisplatin neuropathy

DEFF Research Database (Denmark)

Krarup-Hansen, A; Helweg-Larsen, Susanne Elisabeth; Schmalbruch, H

2007-01-01

of large dorsal root ganglion cells. Motor conduction studies, autonomic function and warm and cold temperature sensation remained unchanged at all doses of cisplatin treatment. The results of these studies are consistent with degeneration of large sensory neurons whereas there was no evidence of distal......Although it is well known that cisplatin causes a sensory neuropathy, the primary site of involvement is not established. The clinical symptoms localized in a stocking-glove distribution may be explained by a length dependent neuronopathy or by a distal axonopathy. To study whether the whole neuron...

Neuronal involvement in cisplatin neuropathy

DEFF Research Database (Denmark)

Krarup-Hansen, A; Helweg-Larsen, Susanne Elisabeth; Schmalbruch, H

2007-01-01

Although it is well known that cisplatin causes a sensory neuropathy, the primary site of involvement is not established. The clinical symptoms localized in a stocking-glove distribution may be explained by a length dependent neuronopathy or by a distal axonopathy. To study whether the whole neuron...... of the foot evoked by a tactile probe showed similar changes to those observed in SNAPs evoked by electrical stimulation. At these doses, somatosensory evoked potentials (SEPs) from the tibial nerve had increased latencies of peripheral, spinal and central responses suggesting loss of central processes...

The local investment in renewable energies; L'investissement local dans les energies renouvelables

Energy Technology Data Exchange (ETDEWEB)

Poussard, E.; Quantin, J.; Grepmeier, K.; Larsen, J.; Manolakaki, E.; Twele, J

2003-07-01

These proceedings present some European testimonies about the advantage of local investment, illustrated with concrete cases taken in Germany, Denmark and Switzerland. They demonstrate that local investment in renewable energy sources is a reality and that this practice has indisputably contributed to their significant development in some countries of the European Union. The sustain of foreign banks to the financing of renewable energy sources is at the evidence an example to follow up in countries like France, Greece or Spain. Important efforts have to be made to simplify and encourage the implementation of projects, in particular from the administrative point of view. Beyond the financial aspects, the colloquium has shown that these practices of citizenship involvement represent an important factor of social adaptation and acceptation. The projects, gathering local actors but also the overall citizens through common investment funds, ensure a better territorial anchoring and a sustain to local and sustainable development. This document has been published with the support of the European Commission and ADEME (French Agency for Environment and Energy Management). (J.S.)

Civic engagement and local government strategies for sustainable local community development

DEFF Research Database (Denmark)

Larsen, Jacob Norvig

Across Europe more and more citizens involve in voluntary grassroots and NGO activity. Concurrently, more local and national governments express an interest in increasing collaboration with voluntary organisations. The curiosity and interest as regards voluntary labour from public bodies seems...... to have grown as the financial crisis puts more and more pressure on municipal and national budgets. As such, the contribution of voluntary associations is seem as a supplement to more and more reduced public services, particularly within the social services field, care for the elderly, etc. but even...... in local communities and in relation to social capital, the diversity within the world of voluntary organisations, and the difference in views between public planners and volunteers of the role of volunteers. Three cases illustrate this as well as the need for capacity building of VCOs and the urban...

Performance Analysis of Local Ensemble Kalman Filter

Science.gov (United States)

Tong, Xin T.

2018-03-01

Ensemble Kalman filter (EnKF) is an important data assimilation method for high-dimensional geophysical systems. Efficient implementation of EnKF in practice often involves the localization technique, which updates each component using only information within a local radius. This paper rigorously analyzes the local EnKF (LEnKF) for linear systems and shows that the filter error can be dominated by the ensemble covariance, as long as (1) the sample size exceeds the logarithmic of state dimension and a constant that depends only on the local radius; (2) the forecast covariance matrix admits a stable localized structure. In particular, this indicates that with small system and observation noises, the filter error will be accurate in long time even if the initialization is not. The analysis also reveals an intrinsic inconsistency caused by the localization technique, and a stable localized structure is necessary to control this inconsistency. While this structure is usually taken for granted for the operation of LEnKF, it can also be rigorously proved for linear systems with sparse local observations and weak local interactions. These theoretical results are also validated by numerical implementation of LEnKF on a simple stochastic turbulence in two dynamical regimes.

Localized scleroderma en coup de sabre in the Neurology Clinic.

Science.gov (United States)

Pinho, João; Rocha, João; Sousa, Filipa; Macedo, Cristiana; Soares-Fernandes, João; Cerqueira, João; Maré, Ricardo; Lourenço, Esmeralda; Pereira, João

2016-07-01

Localized scleroderma en coup de sabre (LScs) is a form of localized scleroderma thought to be an autoimmune disorder. Central nervous system involvement is not rare and neurological manifestations include seizures, focal neurological deficits, headache and neuropsychiatric changes. Patients attending the Neurology Clinic with the final diagnosis of LScs with neurological manifestations were identified and clinical and imagiological records reviewed. Five patients (0.024%) had LScs with neurological involvement, presenting with transient focal neurologic deficits, seizures, headache or migraine with aura. Neuroimaging studies confirmed localized skin depression and showed bone thinning, white matter lesions, brain calcifications, sulcal effacement and meningeal enhancement. Three patients experienced clinical improvement after immunosuppressive therapy, and in two of these patients neuroimaging findings also improved. Recognizing typical dermatologic changes is keystone for the diagnosis of LScs with neurological involvement. It is a diagnosis of exclusion and extensive etiological diagnostic evaluation should be performed. Treatment options, including conservative follow-up or immunosuppressive therapy, should be carefully considered. Copyright © 2016 Elsevier B.V. All rights reserved.

Traditional knowledge for promotion of socioeconomic inclusion of local communities

Directory of Open Access Journals (Sweden)

Waldemiro Francisco Sorte Junior

2012-06-01

Full Text Available This paper discusses the key role played by public research institutes for promoting socioeconomic inclusion of local communities based on traditional knowledge and traditional medicine. Nongovernmental organizations and cooperatives have had an important role in raising financial resources, being involved with advocacy of local communities and advancing legislation changes. But strict best manufacturing practices regulations imposed by the Brazilian National Health Surveillance Agency on the requirements for approval and commercialization of drugs based on herbal medicine products call for the involvement of strong public research institutes capable of supporting community-based pharmacies. Thus, public research institutes are pivotal as they can conduct scientific research studies to evidence the efficacy of herbal medicine products and help building the capacity of local communities to comply with current regulations.

Localizing genes to cerebellar layers by classifying ISH images.

Directory of Open Access Journals (Sweden)

Lior Kirsch

Full Text Available Gene expression controls how the brain develops and functions. Understanding control processes in the brain is particularly hard since they involve numerous types of neurons and glia, and very little is known about which genes are expressed in which cells and brain layers. Here we describe an approach to detect genes whose expression is primarily localized to a specific brain layer and apply it to the mouse cerebellum. We learn typical spatial patterns of expression from a few markers that are known to be localized to specific layers, and use these patterns to predict localization for new genes. We analyze images of in-situ hybridization (ISH experiments, which we represent using histograms of local binary patterns (LBP and train image classifiers and gene classifiers for four layers of the cerebellum: the Purkinje, granular, molecular and white matter layer. On held-out data, the layer classifiers achieve accuracy above 94% (AUC by representing each image at multiple scales and by combining multiple image scores into a single gene-level decision. When applied to the full mouse genome, the classifiers predict specific layer localization for hundreds of new genes in the Purkinje and granular layers. Many genes localized to the Purkinje layer are likely to be expressed in astrocytes, and many others are involved in lipid metabolism, possibly due to the unusual size of Purkinje cells.

Localized tenosynovial giant cell tumor in both knee joints

International Nuclear Information System (INIS)

Kim, Hyun Su; Kwon, Jong Won; Ahn, Jin Hwan; Chang, Moon Jong; Cho, Eun Yoon

2010-01-01

Tenosynovial giant cell tumor, previously called pigmented villonodular synovitis (PVNS), is a rare benign neoplastic process that may involve the synovium of the joint. The disorder is usually monoarticular and only a few cases have been reported on polyarticular involvement. Herein, we present a case of localized intra-articular tenosynovial giant cell tumor in a 29-year-old man involving both knee joints with a description of the MR imaging and histological findings. (orig.)

Detecting measurement-induced relative-position localization

International Nuclear Information System (INIS)

Knott, P A; Sindt, J; Dunningham, J A

2013-01-01

The theory of decoherence explains how classicality emerges from an underlying quantum reality. An additional interpretation to this has been proposed in which scattering events induce the localization of relative observables (Rau et al 2003 Science 301 1081). An interesting consequence of this process is that it involves the build-up of certain robust entanglements between the observables being localized. To date the weakness of this interpretation has been the lack of a clear experimental signature that allows it to be tested. Here we provide a simple experimentally accessible scheme that enables just that. We also discuss a Bayesian technique that could, in principle, allow experiments to confirm the localization to any desired degree of accuracy and we present precision requirements that are achievable with current experiments. Finally, we extend the scheme from its initial one dimensional proof of principle to the more real world scenario of three dimensional localization. (paper)

Public involvement plan for the Oak Ridge Reservation. Revision 1

International Nuclear Information System (INIS)

1995-03-01

For the past few years, the Department of Energy (DOE) has increased its efforts to involve the public in environmental management decisions. On the national level, Energy Secretary Hazel O'Leary has declared public involvement one of DOE's most important objectives. On the local level, citizens are taking the microphone at DOE public hearings to voice their opinions and ask tough, detailed questions about proposed cleanup plans. To ensure that it hears, understands and responds to public input from all of its neighbors, DOE-Oak Ridge Operations has developed an Environmental Management Public Involvement Program to keep stakeholders--those affected or potentially affected by cleanup programs--informed about environmental management work on the Oak Ridge Reservation and opportunities for public comment. This Public Involvement Plan contains information about the Oak Ridge Public Involvement Program its history, goals and proposed interactions with stakeholders. It also contains information to help area citizens become involved or increase their involvement in helping DOE make responsible environmental management decisions

Lay and professional stakeholder involvement in scoping palliative care issues: Methods used in seven European countries.

Science.gov (United States)

Brereton, Louise; Ingleton, Christine; Gardiner, Clare; Goyder, Elizabeth; Mozygemba, Kati; Lysdahl, Kristin Bakke; Tummers, Marcia; Sacchini, Dario; Leppert, Wojciech; Blaževičienė, Aurelija; van der Wilt, Gert Jan; Refolo, Pietro; De Nicola, Martina; Chilcott, James; Oortwijn, Wija

2017-02-01

Stakeholders are people with an interest in a topic. Internationally, stakeholder involvement in palliative care research and health technology assessment requires development. Stakeholder involvement adds value throughout research (from prioritising topics to disseminating findings). Philosophies and understandings about the best ways to involve stakeholders in research differ internationally. Stakeholder involvement took place in seven countries (England, Germany, Italy, Lithuania, the Netherlands, Norway and Poland). Findings informed a project that developed concepts and methods for health technology assessment and applied these to evaluate models of palliative care service delivery. To report on stakeholder involvement in the INTEGRATE-HTA project and how issues identified informed project development. Using stakeholder consultation or a qualitative research design, as appropriate locally, stakeholders in seven countries acted as 'advisors' to aid researchers' decision making. Thematic analysis was used to identify key issues across countries. A total of 132 stakeholders (82 professionals and 50 'lay' people) aged ⩾18 participated in individual face-to-face or telephone interviews, consultation meetings or focus groups. Different stakeholder involvement methods were used successfully to identify key issues in palliative care. A total of 23 issues common to three or more countries informed decisions about the intervention and comparator of interest, sub questions and specific assessments within the health technology assessment. Stakeholders, including patients and families undergoing palliative care, can inform project decision making using various involvement methods according to the local context. Researchers should consider local understandings about stakeholder involvement as views of appropriate and feasible methods vary. Methods for stakeholder involvement, especially consultation, need further development.

Clinical review: surgical management of locally advanced and recurrent colorectal cancer.

LENUS (Irish Health Repository)

Courtney, D

2014-01-01

Recurrent and locally advanced colorectal cancers frequently require en bloc resection of involved organs to achieve negative margins. The aim of this review is to evaluate the most current literature related to the surgical management of locally advanced and recurrent colorectal cancer.

Localization of lesions in aphasia, (2)

International Nuclear Information System (INIS)

Hojo, Kei; Watanabe, Shunzo; Tasaki, Hiroichi; Sato, Tokijiro; Metoki, Hirofumi.

1985-01-01

The relationship between the focus and the extent of the lesions and the various symptoms was investigated. 1. Broca aphasics: More than 80% of the group with obvious anarthric components had lesions of the third frontal gyrus involving Broca's area and the lower part of the precental gyrus as well as opercular and insular regions. The size of the lesions of this group was significantly larger than that of the group without marked anarthric components, and the latter was proved to have little localizing value. 2. Wernicke aphasics: The group with poor reading comprehension had cortical and/or subcortical lesions, involving posterior parts of both superior and middle temporal gyri as well as the supramarginal gyrus. On the other hand, lesions of the group with poor auditory comprehension were more anteriorly located and localized in the deep structures. Lesions of the group with poor Token test scores were large and scattered more anteriorly and/or posteriorly compared with those of the group with good Token test scores. 3. Amnestic aphaiscs: The group with poor naming scores had somewhat larger lesions than the group with good naming scores, and the lesions were scattered about the left hemisphere. The finding has proved that both groups had little localizing value. 4. Conduction aphasics: Lesions of the non-fluent type were significantly larger than those of the fluent type and distributed more anteriorly. However, highly involved lesions were located in the supramarginal gyrus and posterior parts of superior and/or middle temporal gyri. 5. Global aphasics: Lesions of the group with good articulation and prosody were observed to distribute more posteriorly in comparison with those of the other global aphasics. (J.P.N.)

The relationship between the local temperature and the local heat flux within a one-dimensional semi-infinite domain of heat wave propagation

Directory of Open Access Journals (Sweden)

Kulish Vladimir V.

2003-01-01

Full Text Available The relationship between the local temperature and the local heat flux has been established for the homogeneous hyperbolic heat equation. This relationship has been written in the form of a convolution integral involving the modified Bessel functions. The scale analysis of the hyperbolic energy equation has been performed and the dimensionless criterion for the mode of energy transport, similar to the Reynolds criterion for the flow regimes, has been proposed. Finally, the integral equation, relating the local temperature and the local heat flux, has been solved numerically for those processes of surface heating whose time scale is of the order of picoseconds.

U.S. EPA Superfund Program's Policy for Community Involvement at Radioactively Contaminated Sites

International Nuclear Information System (INIS)

Martin, K.; Walker, St.

2009-01-01

This paper describes the EPA Superfund program's statutory requirements for community involvement. It also discusses the efforts the Superfund program has made that go beyond these statutory requirements to involve communities, and what lessons have been learned by EPA when trying to conduct meaningful community involvement at sites. In addition, it discusses tools that EPA has designed to specifically enhance community involvement at radioactively contaminated Superfund sites. In summary, the Superfund program devotes substantial resources to involving the local community in the site cleanup decision making process. We believe community involvement provides us with highly valuable information that must be available to carefully consider remedial alternatives at a site. We also find our employees enjoy their jobs more. Rather than fighting with an angry public they can work collaboratively to solve the problems created by the hazardous waste sites. We have learned the time and resources we devote at the beginning of a project to developing relationships with the local community, and learning about their issues and concerns is time and resources well spent. We believe the evidence shows this up-front investment helps us make better cleanup decisions, and avoids last minute efforts to work with a hostile community who feels left out of the decision-making process. (authors)

Electron localization in water clusters

International Nuclear Information System (INIS)

Landman, U.; Barnett, R.N.; Cleveland, C.L.; Jortner, J.

1987-01-01

Electron attachment to water clusters was explored by the quantum path integral molecular dynamics method, demonstrating that the energetically favored localization mode involves a surface state of the excess electron, rather than the precursor of the hydrated electron. The cluster size dependence, the energetics and the charge distribution of these novel electron-cluster surface states are explored. 20 refs., 2 figs., 1 tab

Layer-Mean Quantities, Local Conservation Laws, and Vorticity

International Nuclear Information System (INIS)

Camassa, R.; Levermore, C.D.

1997-01-01

We derive local conservation laws for layer-mean quantities in two general settings. When applied to Euler flows, the first of these settings yields well-known local conservation laws for quantities averaged between material surfaces. The second, however, leads to new local conservation laws for quantities involving the vorticity that are averaged between arbitrary surfaces. These produce the crucial vorticity conservation laws in shallow water models that admit nonhydrostatic and noncolumnar motion. Moreover, they seem to lie outside the Hamiltonian paradigm of fluid dynamics. The formalism generalizes to skew-symmetric matrix fields; applications to electromagnetism are suggested. copyright 1997 The American Physical Society

National Reform Programs in Local Practices

DEFF Research Database (Denmark)

Hjelholt, Morten; Jensen, Tina Blegind

. In particular, we emphasize the practices in which national strategic formulations are legitimized and accepted or abandoned by the actors involved. Building on a case study conducted over a two-year time span, we show how a local actor engages with and promotes a national reform program by evoking a discourse...

Putrescine-Dependent Re-Localization of TvCP39, a Cysteine Proteinase Involved in Trichomonas vaginalis Cytotoxicity

OpenAIRE

Carvajal-Gamez, Bertha Isabel; Quintas-Granados, Laura Itzel; Arroyo, Rossana; Vázquez-Carrillo, Laura Isabel; Ramón-Luing, Lucero De los Angeles; Carrillo-Tapia, Eduardo; Alvarez-Sánchez, María Elizbeth

2014-01-01

Polyamines are involved in the regulation of some Trichomonas vaginalis virulence factors such as the transcript, proteolytic activity, and cytotoxicity of TvCP65, a cysteine proteinase (CP) involved in the trichomonal cytotoxicity. In this work, we reported the putrescine effect on TvCP39, other CP that also participate in the trichomonal cytotoxicity. Parasites treated with 1,4-diamino-2-butanone (DAB) (an inhibitor of putrescine biosynthesis), diminished the amount and proteolytic activity...

The effect of brain lesions on sound localization in complex acoustic environments.

Science.gov (United States)

Zündorf, Ida C; Karnath, Hans-Otto; Lewald, Jörg

2014-05-01

Localizing sound sources of interest in cluttered acoustic environments--as in the 'cocktail-party' situation--is one of the most demanding challenges to the human auditory system in everyday life. In this study, stroke patients' ability to localize acoustic targets in a single-source and in a multi-source setup in the free sound field were directly compared. Subsequent voxel-based lesion-behaviour mapping analyses were computed to uncover the brain areas associated with a deficit in localization in the presence of multiple distracter sound sources rather than localization of individually presented sound sources. Analyses revealed a fundamental role of the right planum temporale in this task. The results from the left hemisphere were less straightforward, but suggested an involvement of inferior frontal and pre- and postcentral areas. These areas appear to be particularly involved in the spectrotemporal analyses crucial for effective segregation of multiple sound streams from various locations, beyond the currently known network for localization of isolated sound sources in otherwise silent surroundings.

Localized scleroderma: a series of 52 patients.

Science.gov (United States)

Toledano, C; Rabhi, S; Kettaneh, A; Fabre, B; Fardet, L; Tiev, K P; Cabane, J

2009-05-01

Localized scleroderma also called morphea is a skin disorder of undetermined cause. The widely recognized Mayo Clinic Classification identifies 5 main morphea types: plaque, generalized, bullous, linear and deep. Whether each of these distinct types has a particular clinical course or is associated with some patient-related features is still unclear. We report here a retrospective series of patients with localized scleroderma with an attempt to identify features related to the type of lesion involved. The medical records of all patients with a diagnosis of localized scleroderma were reviewed by skilled practitioners. Lesions were classified according to the Mayo Clinic Classification. The relationship between each lesion type and various clinical features was tested by non-parametrical methods. The sample of 52 patients included 43 females and 9 males. Median age at onset was 30 y (range 1-76). Frequencies of patients according to morphea types were: plaque morphea 41 (78.8%) (including morphea en plaque 30 (57.7%) and atrophoderma of Pasini-Pierini 11 (21.1%)), linear scleroderma 14 (26.9%). Nine patients (17.3%) had both types of localized scleroderma. Median age at onset was lower in patients with linear scleroderma (8 y (range 3-44)) than in others (36 y (range 1-77)) (p=0.0003). Head involvement was more common in patients with linear scleroderma (37.5%) than in other subtypes (11.1%) (p=0.05). Atrophoderma of Pasini-Pierini was never located at the head. Systemic symptoms, antinuclear antibodies and the rheumatic factor were not associated with localized scleroderma types or subtypes. These results suggest that morphea types, in adults are not associated with distinct patient features except for age at disease onset (lower) and the localization on the head (more frequent), in patients with lesions of the linear type.

Disseminated Mycobacterium celatum disease with prolonged pulmonary involvement

DEFF Research Database (Denmark)

Patsche, Cecilie Blenstrup; Svensson, Erik; Wejse, Christian

2014-01-01

Mycobacterium celatum is a rare cause of human infection, causing disseminated disease in immunosuppressed individuals. Infections localized to the lungs and the lymph nodes have also been reported in immunocompetent individuals. The existing literature on the subject is limited as are experiences...... with treatment regimens and durations. In the case presented herein, two different treatment regimens were applied to an immunocompromised HIV-negative patient with primary skin involvement and extensive pulmonary involvement due to suspected relapse on isoniazid, ethambutol, and clarithromycin treatment....... The treatment regimen was changed to azithromycin, ciprofloxacin, and pyrazinamide and the treatment duration was prolonged to a total of 24 months, with good effect....

User involvement in measuring service quality of local authority occupational therapy services: a new approach.

NARCIS (Netherlands)

Sixma, H.J.; Calnan, S.; Calnan, M.; Groenewegen, P.P.

2001-01-01

The aim of this paper is two-fold: (i) to describe the development of a new measuring instrument for quality of care from the perspective of the users of local authority Occupational Therapy (OT) services, and (ii) to evaluate the potential of the new instrument as a standardized approach for the

Localized basal meningeal enhancement in tuberculous meningitis

Energy Technology Data Exchange (ETDEWEB)

Theron, Salomine; Andronikou, Savvas; Grobbelaar, Marie; Steyn, Freda; Mapukata, Ayanda; Plessis, Jaco du [University of Stellenbosch, Department of Radiology, Tygerberg Hospital, P.O. BOX 19063, Tygerberg (South Africa)

2006-11-15

Focal basal meningeal enhancement may produce a confusing CT picture in children with suspected tuberculous meningitis (TBM). To demonstrate the incidence, distribution and appearance of localized basal meningeal enhancement in children with TBM. CT scans of patients with definite (culture proven) and probable (CSF suggestive) TBM were retrospectively evaluated by two observers. Localized basal enhancement was documented as involving: unilateral cistern of the lateral fossa (CLF), unilateral sylvian fissure, unilateral CLF and sylvian fissure in combination, unilateral CLF and sylvian fissure with ipsi- or contralateral ambient cistern and isolated quadrigeminal plate cistern. The study included 130 patients with TBM (aged 2 months to 13 years 9 months). Focal basal enhancement was seen in 11 patients (8.5%). The sylvian fissure was involved most commonly, followed by the lateral fossa cistern. The ambient cistern was involved in three patients and the quadrigeminal plate cistern in one. Focal areas of enhancement corresponded to the areas of infarction in every patient. Focal basal meningeal enhancement is common (8.5%) in paediatric TBM. This must be kept in mind when evaluating CT scans in children presenting with focal neurological findings, seizures or meningism in communities where TBM is endemic. (orig.)

Localized basal meningeal enhancement in tuberculous meningitis

International Nuclear Information System (INIS)

Theron, Salomine; Andronikou, Savvas; Grobbelaar, Marie; Steyn, Freda; Mapukata, Ayanda; Plessis, Jaco du

2006-01-01

Focal basal meningeal enhancement may produce a confusing CT picture in children with suspected tuberculous meningitis (TBM). To demonstrate the incidence, distribution and appearance of localized basal meningeal enhancement in children with TBM. CT scans of patients with definite (culture proven) and probable (CSF suggestive) TBM were retrospectively evaluated by two observers. Localized basal enhancement was documented as involving: unilateral cistern of the lateral fossa (CLF), unilateral sylvian fissure, unilateral CLF and sylvian fissure in combination, unilateral CLF and sylvian fissure with ipsi- or contralateral ambient cistern and isolated quadrigeminal plate cistern. The study included 130 patients with TBM (aged 2 months to 13 years 9 months). Focal basal enhancement was seen in 11 patients (8.5%). The sylvian fissure was involved most commonly, followed by the lateral fossa cistern. The ambient cistern was involved in three patients and the quadrigeminal plate cistern in one. Focal areas of enhancement corresponded to the areas of infarction in every patient. Focal basal meningeal enhancement is common (8.5%) in paediatric TBM. This must be kept in mind when evaluating CT scans in children presenting with focal neurological findings, seizures or meningism in communities where TBM is endemic. (orig.)

Geological disposal of radioactive wastes: national commitment, local and regional involvement. A Collective Statement of the OECD Nuclear Energy Agency 'Radioactive Waste Management Committee', adopted March 2011

International Nuclear Information System (INIS)

2012-01-01

Disposal in engineered facilities built in stable, deep geological formations is the reference solution for permanently isolating long-lived radioactive waste from the human biosphere. This management method is designed to be intrinsically safe and final, i.e. not dependent on human presence and intervention in order to fulfil its safety goal. Siting waste repositories brings up a range of issues that touch on scientific knowledge, technical capacity, ethical values, territorial planning, community well-being, and more. Bringing to fruition the multi-decades task of siting and developing a repository demands a strong national commitment and a significant regional and local involvement. This Collective Statement by the Radioactive Waste Management Committee of the OECD Nuclear Energy Agency recognizes the advances made toward greater transparency and dialogue among the diverse relevant stakeholders and identifies the fundamental ingredients needed to support national commitment and foster territorial involvement. It concludes that technical and societal partners can develop shared confidence in the safety of geological repositories and jointly carry these projects forward

Local forms of governance in Denmark

DEFF Research Database (Denmark)

Torfing, Jacob

2010-01-01

of representative democracy. The supplement is taking its revenge as the interactive policy arenas are expanding and the role of elected politicians is being transformed from sovereign rulers to meta-governors. This development poses important challenges to the demand for effective and democratic governing......The proliferation of local forms of governance problematizes the well-established and highly normative idea that power and democracy in Denmark are organized in terms of a 'parliamentary chain of government', according to which the sovereign people elect the parliament, which in turn controls...... the government that governs the public administration through bureaucratic control. Consecutive waves of devolution have decentralized the Danish welfare state, and the power of local governments is now being challenged by the emergence of new forms of local governance that involve a plethora of private...

Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events

Science.gov (United States)

Potrykus, Joanna; Stead, David; MacCallum, Donna M.; Urgast, Dagmar S.; Raab, Andrea; van Rooijen, Nico; Feldmann, Jörg; Brown, Alistair J. P.

2013-01-01

Nutritional immunity – the withholding of nutrients by the host – has long been recognised as an important factor that shapes bacterial-host interactions. However, the dynamics of nutrient availability within local host niches during fungal infection are poorly defined. We have combined laser ablation-inductively coupled plasma mass spectrometry (LA-ICP MS), MALDI imaging and immunohistochemistry with microtranscriptomics to examine iron homeostasis in the host and pathogen in the murine model of systemic candidiasis. Dramatic changes in the renal iron landscape occur during disease progression. The infection perturbs global iron homeostasis in the host leading to iron accumulation in the renal medulla. Paradoxically, this is accompanied by nutritional immunity in the renal cortex as iron exclusion zones emerge locally around fungal lesions. These exclusion zones correlate with immune infiltrates and haem oxygenase 1-expressing host cells. This local nutritional immunity decreases iron availability, leading to a switch in iron acquisition mechanisms within mature fungal lesions, as revealed by laser capture microdissection and qRT-PCR analyses. Therefore, a complex interplay of systemic and local events influences iron homeostasis and pathogen-host dynamics during disease progression. PMID:24146619

Local agenda 21 and planning practice: structural transformation or window dressing?

OpenAIRE

Doak, Joe

2001-01-01

Local Agenda 21 seeks the meaningful involvement of a wide range of local groups and stakeholders in the formulation and implementation of public policy and a free flow of communication and discussion between them and their respective local authorities (and other areas and levels of decision-making). This paper explores the reality of this process using case study evidence from local planning practice in Liverpool (in the north of England) and Reading (in the south of the country). It concent...

Are quasars local

International Nuclear Information System (INIS)

Terrell, J.

1974-01-01

The problems of interpreting quasars as galaxies, at distances of billions of light-years, seem to be increasing with time and with observational knowledge. The incredibly large energy and brightness requirements, the very small size and thus high surface brightness required by their rapid fluctuations in luminosity, the recently-discovered radio-source separation speeds apparently much greater than the speed of light, their general lack of association with distant galaxies, and many other properties are all very difficult to explain on the basis of cosmological distance. The very local quasar model, involving much less massive and bright objects--perhaps similar to Type O stars--emitted at relativistic speeds by the center of our own galaxy, greatly eases these difficulties. Since such ejected objects also seem necessary to explain the similarly strange properties of radio galaxies, the emission of local quasars from some galaxies might be deduced on this basis alone. (6 figures) (U.S.)

Observer efficiency in free-localization tasks with correlated noise

Directory of Open Access Journals (Sweden)

Craig eAbbey

2014-05-01

Full Text Available The efficiency of visual tasks involving localization has traditionally been evaluated using forced choice experiments that capitalize on independence across locations to simplify the performance of the ideal observer. However, developments in ideal observer analysis have shown how an ideal observer can be defined for free-localization tasks, where a target can appear anywhere in a defined search region and subjects respond by localizing the target. Since these tasks are representative of many real-world search tasks, it is of interest to evaluate the efficiency of observer performance in them. The central question of this work is whether humans are able to effectively use the information in a free-localization task relative to a similar task where target location is fixed. We use a yes-no detection task at a cued location as the reference for this comparison. Each of the tasks is evaluated using a Gaussian target profile embedded in four different Gaussian noise backgrounds having power-law noise power spectra with exponents ranging from 0 to 3. The free localization task had a square 6.7° search region. We report on two follow-up studies investigating efficiency in a detect-and-localize task, and the effect of processing the white-noise backgrounds. In the fixed-location detection task, we find average observer efficiency ranges from 35% to 59% for the different noise backgrounds. Observer efficiency improves dramatically in the tasks involving localization, ranging from 63% to 82% in the forced localization tasks and from 78% to 92% in the detect-and- localize tasks. Performance in white noise, the lowest efficiency condition, was improved by filtering to give them a power-law exponent of 2. Classification images, used to examine spatial frequency weights for the tasks, show better tuning to ideal weights in the free-localization tasks. The high absolute levels of efficiency suggest that observers are well-adapted to free-localization tasks.

Developing local scenarios to nitrogen management using participatory planning

DEFF Research Database (Denmark)

Piil, Kristoffer; Wiborg, Irene; Andersen, Peter Stubkjær

2017-01-01

incurred significant financial burdens on farmers, as well as restricting their freedom of operation on their farms. Over the last years, there has been a shift towards a targeted regulation that takes local conditions into account, in order to increase the cost effectiveness of mitigation strategies...... to be taken into account when involving a community in participatory planning regarding nitrogen management. As part of a more targeted Danish regulation, a system of catchment officers is currently being established to aide in formulating mitigation strategies that are adapted to local needs and local...

Quantum non-locality vs. quasi-local measurements in the conditions of the Aharonov-Bohm effect

International Nuclear Information System (INIS)

Gulian, Armen M

2014-01-01

Theoretical explanation of the Meissner effect involves proportionality between current density and vector potential, which has many deep consequences. As noticed by de Gennes, superconductors in a magnetic field 'find an equilibrium state where the sum of kinetic and magnetic energies is minimum' and this state 'corresponds to the expulsion of the magnetic field'. This statement still leaves an open question: from which source is the superconducting current acquiring its kinetic energy? A naïve answer, perhaps, is from the energy of the magnetic field. However, one can consider situations (Aharonov-Bohm effect), where the classical magnetic field is locally absent in the area occupied by the current. Experiments demonstrate that despite the local absence of the magnetic field, current is, nevertheless, building up. From what source is it acquiring its energy then? Locally, only a vector potential is present. How does the vector potential facilitate the formation of the current? Is the current formation a result of a truly non-local quantum action, or does the local action of the vector potential have experimental consequences? We discuss possible experiments with a hybrid normal-metal superconductor circuitry, which can clarify this puzzling situation. Experimental answers will be important for further developments.

The Value of High-Resolution MRI Technique in Patients with Rectal Carcinoma: Pre-Operative Assessment of Mesorectal Fascia Involvement, Circumferential Resection Margin and Local Staging

International Nuclear Information System (INIS)

Algebally, Ahmed Mohamed; Mohey, Nesreen; Szmigielski, Wojciech; Yousef, Reda Ramadan Hussein; Kohla, Samah

2015-01-01

The purpose of the study was to identify the accuracy of high-resolution MRI in the pre-operative assessment of mesorectal fascia involvement, circumfrential resection margin (CRM) and local staging in patients with rectal carcinoma. The study included 56 patients: 32 male and 24 female. All patients underwent high-resolution MRI and had confirmed histopathological diagnosis of rectal cancer located within 15 cm from the anal verge, followed by surgery. MRI findings were compared with pathological and surgical results. The overall accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MRI-based T-staging were 92.8, 88.8%, 96.5%, 96%, and 90.3%, respectively. The accuracy, sensitivity, specificity, PPV, and NPV of MRI-based assessment of CRM were 94.6%, 84.6%, 97.6%, 91.4, and 94.6%, respectively. The accuracy, sensitivity, specificity, PPV, and NPV of MRI-based N-staging were 82.1%, 75%, 67.3%, 60%, and 86.1%, respectively. Preoperative high-resolution rectal MRI is accurate in predicting tumor stage and CRM involvement. MRI is a precise diagnostic tool to select patients who may benefit from neo-adjuvant therapy and to avoid overtreatment in those patients who can proceed directly to surgery

Stakeholder involvement in the management of effluent discharges from nuclear installations in France

International Nuclear Information System (INIS)

Schneider, T.; Gadbois, S.; Heriard Dubreuil, G.; Oudiz, A.

2004-01-01

The involvement of local stakeholders in the decision-making process regarding health, safety and environmental issues is developing in many countries. As far as the management of effluent discharges from nuclear installations in France is concerned, members of Local Commission of Information, including elected people and NGOs, are playing an increasing role in that respect. To deepen the understanding of these risk governance processes, a working group of experts from different institutions was set up in 2000 by the Institute of Radiation Protection and Nuclear Safety (IRSN). The aim of this working group was to 1) analyse the stakeholder involvement processes already in place in France around nuclear and non-nuclear installations; 2) perform case studies of few national and international experiences around nuclear installations (notably concerning the revision of creation authorisation decree of COGEMA La Hague reprocessing plant, the environmental policy of BNFL Sellafield reprocessing plant, the discharges surveillance of EDF Fessenheim nuclear power plant); 3) study the evolution of the regulatory context for the stakeholder involvement. Four main elements, contributing to the social trust emerge from this analysis: 1) the social dynamics of the consultation process, notably with the emergence of 'new' stakeholders such as elected people and NGOs; 2) the readability of the plant follow-up from the point of view of local stakeholders and their involvement in the decision process (the relay role of these 'new' stakeholders); 3) the contribution of the institutional and pluralist expertise to the social trust (broadening of the range of values taken into account); 4) the issue of the local justification of the plant in the prospect of the sustainable development (no risk being acceptable without counter-parts). This paper will address these different issues on the basis of the case studies in the perspective of examining the radiological risk governance process

Local investment in renewable energies

International Nuclear Information System (INIS)

Grepmeier, K.; Larsen, J.; Manolakaki, E.; Quantin, J.; Twele, J.

2003-01-01

This document presents european examples on the interest of the local investment, illustrated by cases studies in Germany, Denmark and Switzerland. Two main points were discussed: the financial tools and the french strategy. The colloquium provided many discussions and analyzes on the possibility of significant contribution to the collective efforts in favor of the public involvement in the renewable energies development in Europe. (A.L.B.)

Public involvement in environmental activities: Initiatives and lessons learned

International Nuclear Information System (INIS)

Gray, R.H.

1995-01-01

Efforts to communicate the results of environmental studies and involve the public in environmental decisions have increased nationwide. Outreach efforts at two US Department of Energy sites (i.e., the Hanford Site in southeastern Washington State and the Pantex Plant in the Texas Panhandle) have used a broad spectrum of communications media, including technical articles (open literature and symposium publications, annual and topical reports); information brochures and fact sheets; video productions; interactive exhibits; presentations at scientific, technical, civic, and other public meetings; and proactive interactions with the news media and with local, state, federal, and other agencies. In addition, representatives of local communities now operate offsite environmental monitoring stations and Native Americans are involved in studying cultural resources, fisheries, and other issues at Hanford and a program to obtain environmental samples from neighbor's property is underway at the Pantex Plant. All major environmental programs, such as the multi-year effort to reconstruct past radiological doses to offsite human populations at Hanford, are now conducted with open public participation

Local Governments Supporting Local Energy Initiatives: Lessons from the Best Practices of Saerbeck (Germany and Lochem (The Netherlands

Directory of Open Access Journals (Sweden)

Thomas Hoppe

2015-02-01

Full Text Available The social dimension of the transition to a low carbon economy is a key challenge to cities. The establishment of local energy initiatives (LEIs has recently been attracting attention. It is of great importance to draw lessons from best practices when LEIs have been facilitated by local governments and made a substantial contribution to greening local energy systems. The main research questions in this paper are: What lessons can be drawn from successful local low carbon energy transition cases, and which strategies proved successful to support LEIs? We have used analytical notions from the Strategic Niche Management (SNM and grassroots innovation literature to analyze two best-practice cases: Saerbeck (Germany and Lochem (The Netherlands. Data collection involved a set of fourteen in-depth interviews and secondary data. The results show that three key factors from SNM (building networks, managing expectations, and facilitation of learning are of great importance. However, to a great degree it is also strategic, community serving, responsive, reflexive leadership and proper process management by public officials that spurred success, which would not have been possible without close interaction and mutual trust between local government and representatives of the local communities.

Restoring locality with faster-than-light velocities

International Nuclear Information System (INIS)

Eberhard, P.H.

1993-01-01

The idea of ''locality'' is a deep rooted concept. It does not have to be abandoned even if ''loophole free'' EPR experiments are performed and confirm the predictions of quantum theory. To satisfy locality, one can imagine that influences at a distance are exerted via mechanisms involving an ether and effects propagating in that ether a velocity V > c. Such model of physical phenomena is not Lorentz invariant but, with V large enough, the model can be made to reproduce the results of all experiments where quantum mechanics and Lorentz invariance have been verified

Parry-Romberg Syndrome Associated with Localized Scleroderma

Directory of Open Access Journals (Sweden)

Jelena Maletic

2010-06-01

Full Text Available Parry-Romberg syndrome is a rare neurocutaneous disorder of unknown origin. It is characterized by progressive facial hemiatrophy and frequently overlaps with a condition known as linear scleroderma ‘en coup de sabre’. Neurological involvement is frequently described in these patients, including migraine, facial pain and epilepsy, which represent the commonest neurological conditions, sometimes associated with brain abnormalities ipsilaterally to the skin lesions. We present a case of Parry-Romberg syndrome with neurological involvement in a patient with diagnosed localized scleroderma (morphea.

Parry-Romberg Syndrome Associated with Localized Scleroderma

Science.gov (United States)

Maletic, Jelena; Tsirka, Vassiliki; Ioannides, Panos; Karacostas, Dimitrios; Taskos, Nikolaos

2010-01-01

Parry-Romberg syndrome is a rare neurocutaneous disorder of unknown origin. It is characterized by progressive facial hemiatrophy and frequently overlaps with a condition known as linear scleroderma ‘en coup de sabre’. Neurological involvement is frequently described in these patients, including migraine, facial pain and epilepsy, which represent the commonest neurological conditions, sometimes associated with brain abnormalities ipsilaterally to the skin lesions. We present a case of Parry-Romberg syndrome with neurological involvement in a patient with diagnosed localized scleroderma (morphea). PMID:20671858

Treatment preferences and involvement in treatment decision making of patients with endometrial cancer and clinicians.

Science.gov (United States)

Kunneman, M; Pieterse, A H; Stiggelbout, A M; Nout, R A; Kamps, M; Lutgens, L C H W; Paulissen, J; Mattheussens, O J A; Kruitwagen, R F P M; Creutzberg, C L

2014-08-12

Vaginal brachytherapy (VBT) in high-intermediate-risk endometrial cancer (EC) provides a significant reduction in the risk of local cancer recurrence, but without survival benefit and with increased mucosal atrophy. Five-year local control is estimated to be similar for VBT and a watchful waiting policy (WWP), in which patients receive VBT combined with external radiation in case of a recurrence. Our aim was to assess treatment preferences of EC patients and clinicians regarding VBT and WWP, and to evaluate their preferred and perceived involvement in treatment decision making. Interviews were held with 95 treated EC patients. The treatment trade-off method was used to assess the minimally desired benefit from VBT in local control. Patients' preferred and perceived involvement in decision making were assessed using a questionnaire. Seventy-seven clinicians completed a questionnaire assessing their minimally desired benefit and preferred involvement in decision making. Minimally desired benefit of VBT was significantly lower for patients than for clinicians (median=0 vs 8%, Pdecision about VBT. However, irradiated patients indicated low perceived involvement in actual treatment decision making. We found variations between and within patients and clinicians in minimally desired benefit from VBT. However, the recurrence risk at which patients preferred VBT was low. Our results showed that patients consider active participation in decision making essential.

Participatory mapping for crime prevention in South Africa - local solutions to local problems

CSIR Research Space (South Africa)

Liebermann, S

2004-10-01

Full Text Available . suburban parts or the central business districts in urban areas is property- related.(3) Links between land use and crime types became apparent when crime statistics were broken down by location at the local scale. Adirect link between undeveloped... step involves setting the scene and discussing crime, place and crime prevention. Many of the resident community participants have never heard of crime prevention, therefore this introductory step outlines the three factors necessary for a crime...

Local agenda 21 and renewable energy

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-10-01

This study, involving a questionnaire survey of UK local authorities, was carried out in order to examine the effectiveness of the Local Agenda 21 (LA21) in promoting the use of renewable energy, overcome barriers to the uptake of renewable energy, collect examples of good practice, and identify the possible role of the Department of Trade and Industry and other governmental programmes in meeting the needs of LA21 which was an outcome of the 1992 Rio de Janeiro Earth Summit. The background to the project, and the government's commitment to increasing the amount of electricity produced from renewable energy sources are discussed along with the setting up of LA21, and key areas where local authorities can help contribute towards LA21. The funding of the study and examples of good practice are discussed. Recommendations are provided.

Isolated Light Chain Amyloidosis Involving the Parotid Gland: A Case Report.

Science.gov (United States)

Gareb, Barzi; Perry, Michael; Tadrous, Paul Joseph

2018-03-08

Amyloidosis in the parotid gland is rare and is usually associated with systemic amyloidosis. Localized amyloidosis in the parotid gland is extremely rare. We present a case of localized light chain amyloidosis of the parotid gland without systemic involvement. A 70-year-old woman presented with an asymptomatic swelling of the right parotid region. The findings of a physical examination, hematologic and biochemical investigations, imaging, and cytology were inconclusive. The patient underwent an extracapsular dissection of the right parotid gland. Histologic analysis showed that the tissue of the right parotid gland mostly consisted of amyloid deposition. The amyloid stained with antibodies to lambda light chains. Additional investigations showed no systemic involvement. The patient is asymptomatic 5 months after surgery. Clinicians should be aware of the possibility of localized amyloid light chain amyloidosis in the parotid gland, especially if magnetic resonance imaging, computed tomography imaging, and ultrasound findings are inconclusive, and they should recognize, evaluate, and treat it accordingly. Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. All rights reserved.

Cortical areas involved in Arabic number reading.

Science.gov (United States)

Roux, F-E; Lubrano, V; Lauwers-Cances, V; Giussani, C; Démonet, J-F

2008-01-15

Distinct functional pathways for processing words and numbers have been hypothesized from the observation of dissociated impairments of these categories in brain-damaged patients. We aimed to identify the cortical areas involved in Arabic number reading process in patients operated on for various brain lesions. Direct cortical electrostimulation was prospectively used in 60 brain mappings. We used object naming and two reading tasks: alphabetic script (sentences and number words) and Arabic number reading. Cortical areas involved in Arabic number reading were identified according to location, type of interference, and distinctness from areas associated with other language tasks. Arabic number reading was sustained by small cortical areas, often extremely well localized (area (Brodmann area 45), the anterior part of the dominant supramarginal gyrus (Brodmann area 40; p area (Brodmann area 37; p areas.

An update on local anesthesia for pediatric dental patients

Science.gov (United States)

Peedikayil, Faizal C.; Vijayan, Ajoy

2013-01-01

Pain control is an important part of dentistry, particularly in the management of children. Behavior guidance, and dose and technique of administration of the local anesthetic are important considerations in the successful treatment of a pediatric patient. The purpose of the present review is to discuss the relevant data on topics involved, and on the current methods available in the administration of local anesthesia used for pediatric dental patients. PMID:25885712

An update on local anesthesia for pediatric dental patients

OpenAIRE

Peedikayil, Faizal C.; Vijayan, Ajoy

2013-01-01

Pain control is an important part of dentistry, particularly in the management of children. Behavior guidance, and dose and technique of administration of the local anesthetic are important considerations in the successful treatment of a pediatric patient. The purpose of the present review is to discuss the relevant data on topics involved, and on the current methods available in the administration of local anesthesia used for pediatric dental patients.

TANDEM - French-German cooperation for local energy transition. 2014-2017 results, 2017-2019 prospects

International Nuclear Information System (INIS)

Turfin, Anne; Maurer, Christiane; Schilken, Peter; Mouchard, Claire; Coquio, Rozenn; Kynast, Helmi

2016-11-01

The simultaneous implementation of the 'Transition energetique' process in France and of the 'Energiewende' process in Germany has resulted in the signature of a number of cooperation agreements between the two States. Since both these energy transition processes are largely based on decentralising energy supplies, close local authority cooperation looks promising. The TANDEM project is jointly led by two local authority networks, Energy Cities and Klima-Buendnis, with co-funding from ADEME (French Environment and Energy Management Agency) and UBA (German Federal Environment Agency). The TANDEM project provides French and German local authorities with a unique opportunity to share information and cooperate on climate protection issues in order to: provide improved mutual understanding of the situation, challenges and framework of climate and energy policies; encourage exchanges on the obstacles and leverages impeding or fostering the attainment of ambitious energy and climate objectives and encourage knowledge transfer; boost close cooperation between local authorities from both countries, involving local stakeholders and citizens; implement the first stages of cooperation projects during the lifetime of the TANDEM project and lay solid foundations for long-term cooperation; relay local authorities' claims and concerns at both national and European levels, aimed at providing them with greater latitude and freedom of action. Approaches specific to each country have been developed to promote energy transition at the local level. A comparative analysis of existing practices, tools and experiences involving research work and interviews will be conducted and made available to the participating authorities as well as to national organisations. This analysis will be used by national organisations to develop and enhance their action and by local authorities to improve mutual understanding during their discussions. Cooperation projects aimed at implementing energy

Establishing Local Reference Dose Values and Optimisation Strategies

International Nuclear Information System (INIS)

Connolly, P.; Moores, B.M.

2000-01-01

The revised EC Patient Directive 97/43 EURATOM introduces the concepts of clinical audit, diagnostic reference levels and optimisation of radiation protection in diagnostic radiology. The application of reference dose levels in practice involves the establishment of reference dose values as actual measurable operational quantities. These values should then form part of an ongoing optimisation and audit programme against which routine performance can be compared. The CEC Quality Criteria for Radiographic Images provides guidance reference dose values against which local performance can be compared. In many cases these values can be improved upon quite considerably. This paper presents the results of a local initiative in the North West of the UK aimed at establishing local reference dose values for a number of major hospital sites. The purpose of this initiative is to establish a foundation for both optimisation strategies and clinical audit as an ongoing and routine practice. The paper presents results from an ongoing trial involving patient dose measurements for several radiological examinations upon the sites. The results of an attempt to establish local reference dose values from measured dose values and to employ them in optimisation strategies are presented. In particular emphasis is placed on the routine quality control programmes necessary to underpin this strategy including the effective data management of results from such programmes and how they can be employed to optimisation practices. (author)

Building local participation and support for ALFRED project

International Nuclear Information System (INIS)

Apostol, M.; Constantin, M.; Diaconu, D.

2016-01-01

At the beginning of 2015, a Local Dialog Group (LDG) was set-up under the FP7 ARCADIA project, as an interface between the implementer of ALFRED demonstrator (Fostering ALfred CONstruction - FALCON consortium) and local community from Mioveni town. The paper discusses the current situation and the possible evolution of the group beyond the ARCADIA project (November 2016). The possible evolution could be the transformation in a Local Committee (LC), this fact leading to the extension of LDG.s actual role, towards a larger participation in decision making process (DMP). Aspects regarding LC construction elements as local context, mission and role, legitimacy, funding and resources, organizing mode, products and outputs, the interaction with other stakeholders, are presented in the paper. In order to describe the context, some general elements concerning the Local Committees (LCs) as tools for the communities. involvement in the DMP are also introduced. (authors)

Involving women.

Science.gov (United States)

Agbo, J

1994-01-01

I am a primary health care (PHC) coordinator working with the May Day Rural project, a local NGO involved in integrated approaches and programs with rural communities in the Ga District of the Greater-Accra region in Ghana. When we talk about the community development approach we must first and foremost recognize that we are talking about women, because in the developing world frequent childbirths mean that her burden of mortality is higher than a man's; her workload is extremely heavy--whether in gardening, farming, other household duties, caring for the sick, or the rearing of children; she has a key role in PHC and community development, because men are always looking for greener pastures elsewhere, leaving the women behind. Women's concerns are critical in most health care projects and women and children are their main beneficiaries. Why not include women in the management team, project design, implementation and evaluation processes? That is what the May Day Rural project is practicing, encouraging women's participation and creating a relationship of trust. full text

Local air quality management: some evidence of current practices

Energy Technology Data Exchange (ETDEWEB)

Beattie, Clare; Newton, Alex; Longhurst, Jim [University of the West of England, Air Quality Research Group, Bristol (United Kingdom)

1998-12-01

The recent legislative changes, notably the Environment Act 1995 and resultant National Air Quality Strategy have brought new powers and obligations to local authorities to reach specified air quality standards and objectives. Initially this will involve local authorities carrying out a review and assessment of air quality in their locality by December 1999. This paper will outline a project currently being undertaken within the University of the West of England investigating how this legislation is being put into practice and present the results from a nation-wide questionnaire survey of environmental health officers. The study found that local authorities are still at an early stage of the process. It seems probable that one possible barrier to the implementation of Air Quality Management will be communication and cooperation within local authorities. (Author)

Emergency planning and preparedness for accidents involving radioactive materials used in medicine, industry, research and teaching

International Nuclear Information System (INIS)

1989-01-01

This Safety Series book should be considered as a technical guide aimed at the users of radioactive materials and the appropriate local and national authorities. It does not represent a single solution to the problems involved but rather draws the outlines of the plans and procedures that have to be developed in order to mitigate the consequences of an accident, should one occur. The preparation of local and national plans should follow the technical recommendations provided in this publication, with due consideration given to local factors which might vary from country to country (e.g. governmental systems, local legislation, quantities of radioactive materials involved). Several types of accidents are described, together with their possible radiological consequences. The basic principles of the protective measures that should be applied are discussed, and the principles of emergency planning and the measures needed to maintain preparedness for an operational response to an accident are outlined

Multiple-Trace Operators and Non-Local String Theories

International Nuclear Information System (INIS)

Silverstein, Eva M.

2001-01-01

We propose that a novel deformation of string perturbation theory, involving non-local interactions between strings, is required to describe the gravity duals of field theories deformed by multiple-trace operators. The new perturbative expansion involves a new parameter, which is neither the string coupling nor the coefficient of a vertex operator on the worldsheet. We explore some of the properties of this deformation, focusing on a special case where the deformation in the field theory is exactly marginal

Elective nodal irradiation (ENI) vs. involved field radiotherapy (IFRT) for locally advanced non-small cell lung cancer (NSCLC): A comparative analysis of toxicities and clinical outcomes

International Nuclear Information System (INIS)

Fernandes, Annemarie T.; Shen, Jason; Finlay, Jarod; Mitra, Nandita; Evans, Tracey; Stevenson, James; Langer, Corey; Lin, Lilie; Hahn, Stephen; Glatstein, Eli; Rengan, Ramesh

2010-01-01

Background: Elective nodal irradiation (ENI) and involved field radiotherapy (IFRT) are definitive radiotherapeutic approaches used to treat patients with locally advanced non-small cell lung cancer (NSCLC). ENI delivers prophylactic radiation to clinically uninvolved lymph nodes, while IFRT only targets identifiable gross nodal disease. Because clinically uninvolved nodal stations may harbor microscopic disease, IFRT raises concerns for increased nodal failures. This retrospective cohort analysis evaluates failure rates and treatment-related toxicities in patients treated at a single institution with ENI and IFRT. Methods: We assessed all patients with stage III locally advanced or stage IV oligometastatic NSCLC treated with definitive radiotherapy from 2003 to 2008. Each physician consistently treated with either ENI or IFRT, based on their treatment philosophy. Results: Of the 108 consecutive patients assessed (60 ENI vs. 48 IFRT), 10 patients had stage IV disease and 95 patients received chemotherapy. The median follow-up time for survivors was 18.9 months. On multivariable logistic regression analysis, patients treated with IFRT demonstrated a significantly lower risk of high grade esophagitis (Odds ratio: 0.31, p = 0.036). The differences in 2-year local control (39.2% vs. 59.6%), elective nodal control (84.3% vs. 84.3%), distant control (47.7% vs. 52.7%) and overall survival (40.1% vs. 43.7%) rates were not statistically significant between ENI vs. IFRT. Conclusions: Nodal failure rates in clinically uninvolved nodal stations were not increased with IFRT when compared to ENI. IFRT also resulted in significantly decreased esophageal toxicity, suggesting that IFRT may allow for integration of concurrent systemic chemotherapy in a greater proportion of patients.

Elective nodal irradiation (ENI) vs. involved field radiotherapy (IFRT) for locally advanced non-small cell lung cancer (NSCLC): A comparative analysis of toxicities and clinical outcomes.

Science.gov (United States)

Fernandes, Annemarie T; Shen, Jason; Finlay, Jarod; Mitra, Nandita; Evans, Tracey; Stevenson, James; Langer, Corey; Lin, Lilie; Hahn, Stephen; Glatstein, Eli; Rengan, Ramesh

2010-05-01

Elective nodal irradiation (ENI) and involved field radiotherapy (IFRT) are definitive radiotherapeutic approaches used to treat patients with locally advanced non-small cell lung cancer (NSCLC). ENI delivers prophylactic radiation to clinically uninvolved lymph nodes, while IFRT only targets identifiable gross nodal disease. Because clinically uninvolved nodal stations may harbor microscopic disease, IFRT raises concerns for increased nodal failures. This retrospective cohort analysis evaluates failure rates and treatment-related toxicities in patients treated at a single institution with ENI and IFRT. We assessed all patients with stage III locally advanced or stage IV oligometastatic NSCLC treated with definitive radiotherapy from 2003 to 2008. Each physician consistently treated with either ENI or IFRT, based on their treatment philosophy. Of the 108 consecutive patients assessed (60 ENI vs. 48 IFRT), 10 patients had stage IV disease and 95 patients received chemotherapy. The median follow-up time for survivors was 18.9 months. On multivariable logistic regression analysis, patients treated with IFRT demonstrated a significantly lower risk of high grade esophagitis (Odds ratio: 0.31, p = 0.036). The differences in 2-year local control (39.2% vs. 59.6%), elective nodal control (84.3% vs. 84.3%), distant control (47.7% vs. 52.7%) and overall survival (40.1% vs. 43.7%) rates were not statistically significant between ENI vs. IFRT. Nodal failure rates in clinically uninvolved nodal stations were not increased with IFRT when compared to ENI. IFRT also resulted in significantly decreased esophageal toxicity, suggesting that IFRT may allow for integration of concurrent systemic chemotherapy in a greater proportion of patients. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Dosimetry of professionals involved in radio guided surgery

International Nuclear Information System (INIS)

Barreto, A. C.; Cardoso, G.; Ferreira, L. S.; Santos, A. I.

2013-01-01

The procedure of sentinel node localization is important because it allows less invasive staging of breast cancer. With the capture probe after intradermal injection of the radiopharmaceutical, the surgeon can identify the location of the sentinel node. The use of radioactive materials, generated considerable concern in terms of radiation exposure. The main objective is to evaluate the possible individual dose of each professional involved in the process of radio-location. (Author)

The local investment in renewable energies

International Nuclear Information System (INIS)

Poussard, E.; Quantin, J.; Grepmeier, K.; Larsen, J.; Manolakaki, E.; Twele, J.

2003-01-01

These proceedings present some European testimonies about the advantage of local investment, illustrated with concrete cases taken in Germany, Denmark and Switzerland. They demonstrate that local investment in renewable energy sources is a reality and that this practice has indisputably contributed to their significant development in some countries of the European Union. The sustain of foreign banks to the financing of renewable energy sources is at the evidence an example to follow up in countries like France, Greece or Spain. Important efforts have to be made to simplify and encourage the implementation of projects, in particular from the administrative point of view. Beyond the financial aspects, the colloquium has shown that these practices of citizenship involvement represent an important factor of social adaptation and acceptation. The projects, gathering local actors but also the overall citizens through common investment funds, ensure a better territorial anchoring and a sustain to local and sustainable development. This document has been published with the support of the European Commission and ADEME (French Agency for Environment and Energy Management). (J.S.)

Nuclear localization of SNARK; its impact on gene expression

International Nuclear Information System (INIS)

Kuga, Wataru; Tsuchihara, Katsuya; Ogura, Tsutomu; Kanehara, Sakyo; Saito, Marie; Suzuki, Atsushi; Esumi, Hiroyasu

2008-01-01

SNARK, a member of the AMPK-related kinases, has been involved in the cellular stress responses but its precise mechanisms remain unclear. Subcellular localization of SNARK protein was identified. Unlike cytoplasmic localizing AMPKα, SNARK was predominantly localized in the nucleus. SNARK was constitutively distributed in the nucleus even when SNARK was activated by metabolic stimuli such as AICAR and glucose-deprivation. Conserved nuclear localization signal (NLS) was identified at the N-terminal portion ( 68 KKAR 71 ). Deletion and point mutation of this part resulted in the cytoplasmic translocation of mutant proteins. Furthermore, GFP fused with the SNARK fragment containing 68 KKAR 71 translocated to the nucleus. A microarray analysis revealed that the nuclear localizing SNARK altered transcriptome profiles and a considerable part of these alterations were canceled by the mutation of NLS, suggesting the ability of SNARK to modulate gene expression dependent on its nuclear localization.

PUBLIC EXPENDITURE ON HEALTH IN LOCAL BUDGETS

Directory of Open Access Journals (Sweden)

Cristinel ICHIM

2017-06-01

Full Text Available This paper entitled "Public expenditure on health in local budgets" aims analysing and deepening major spending categories that public authorities finance at local level, namely health expenditure. In the first part of the article we have specified the content and role of this category of expenditure in local budgets and also made some feedback on decentralization in health. In the second part of the work, based on data available in Statistical Yearbook of Romania, we have carried out an analysis of the dynamics of health spending from local budgets to emphasize their place and role in the health care expenses. The research carried out follows that the evolution and structure of health expenditure financed from local budgets is determined, along with the legislative framework in the field, by several variables that differ from one territorial administrative unit to another: the existence of sanitary units, their type, the involving of local public authorities in their development and modernization, the number and the social structure of the population. The research shows that over the period 1993-2015, the dynamics of the share of health spending in total expenditures of local budgets is sinusoidal, with a minimum threshold in 2000 of only 0.3%.

Coupling of nonlocal and local continuum models by the Arlequinapproach

KAUST Repository

Han, Fei

2011-08-09

The objective of this work is to develop and apply the Arlequin framework to couple nonlocal and local continuum mechanical models. A mechanically-based model of nonlocal elasticity, which involves both contact and long-range forces, is used for the \\'fine scale\\' description in which nonlocal interactions are considered to have non-negligible effects. Classical continuum mechanics only involving local contact forces is introduced for the rest of the structure where these nonlocal effects can be neglected. Both models overlap in a coupling subdomain called the \\'gluing area\\' in which the total energy is separated into nonlocal and local contributions by complementary weight functions. A weak compatibility is ensured between kinematics of both models using Lagrange multipliers over the gluing area. The discrete formulation of this specific Arlequin coupling framework is derived and fully described. The validity and limits of the technique are demonstrated through two-dimensional numerical applications and results are compared against those of the fully nonlocal elasticity method. © 2011 John Wiley & Sons, Ltd.

Michigan Wetlands: Yours To Protect. A Citizen's Guide to Local Involvement in Wetland Protection. Second Edition.

Science.gov (United States)

Cwikiel, Wilfred

This guidebook is designed to assist concerned Michigan citizens, local governments, conservation organizations, landowners, and others in their efforts to initiate wetlands protection activities. Chapter 1 focuses on wetland functions, values, losses, and the urgent need to protect wetland resources. Chapter 2 discusses wetland identification and…

Neurologic Involvement in Scleroderma en Coup de Sabre

Science.gov (United States)

Amaral, Tiago Nardi; Marques Neto, João Francisco; Lapa, Aline Tamires; Peres, Fernando Augusto; Guirau, Caio Rodrigues; Appenzeller, Simone

2012-01-01

Localized scleroderma is a rare disease, characterized by sclerotic lesions. A variety of presentations have been described, with different clinical characteristics and specific prognosis. In scleroderma en coup de sabre (LScs) the atrophic lesion in frontoparietal area is the disease hallmark. Skin and subcutaneous are the mainly affected tissues, but case reports of muscle, cartilage, and bone involvement are frequent. These cases pose a difficult differential diagnosis with Parry-Romberg syndrome. Once considered an exclusive cutaneous disorder, the neurologic involvement present in LScs has been described in several case reports. Seizures are most frequently observed, but focal neurologic deficits, movement disorders, trigeminal neuralgia, and mimics of hemiplegic migraines have been reported. Computed tomography and magnetic resonance imaging have aided the characterization of central nervous system lesions, and cerebral angiograms have pointed to vasculitis as a part of disease pathogenesis. In this paper we describe the clinical and radiologic aspects of neurologic involvement in LScs. PMID:22319646

Biometric feature extraction using local fractal auto-correlation

International Nuclear Information System (INIS)

Chen Xi; Zhang Jia-Shu

2014-01-01

Image texture feature extraction is a classical means for biometric recognition. To extract effective texture feature for matching, we utilize local fractal auto-correlation to construct an effective image texture descriptor. Three main steps are involved in the proposed scheme: (i) using two-dimensional Gabor filter to extract the texture features of biometric images; (ii) calculating the local fractal dimension of Gabor feature under different orientations and scales using fractal auto-correlation algorithm; and (iii) linking the local fractal dimension of Gabor feature under different orientations and scales into a big vector for matching. Experiments and analyses show our proposed scheme is an efficient biometric feature extraction approach. (condensed matter: structural, mechanical, and thermal properties)

Creating and managing radioactive waste disposal facilities with the involvement of the local populations - 59286

International Nuclear Information System (INIS)

Farin, Sebastien

2012-01-01

Document available in abstract form only. Full text of publication follows: Andra is responsible for proposing and implementing industrial management solutions for all French radioactive waste. Andra is in particular in charge of operating the two repositories in the Aube region, monitoring the Manche repository one of the world's first surface repositories and creating disposal facilities for waste currently without an operational disposal solution. Andra's communication approach. Andra's communication role is stipulated by law and is an integral part of its activities, in the same way as research, industry or risk management. Andra's aim is to make the subject of radioactive waste management one that is of nationwide interest comprehensible to the largest possible number, so that each citizen and stakeholder can, in full possession of the facts, make his or her own opinion and finally reach an informed decision. Andra's communication policy is based on four main levers: - Information, through a full range of tools (web sites, publications, periodicals) adapted to the level of expertise and understanding of its various target audiences; - Explanation, by means of opportunities throughout the year for those interested in the subject (site visits, fairs, meetings with schools, travelling exhibitions, etc.); - Local integration, through regular relations with local players

Variation in circumferential resection margin: Reporting and involvement in the South-Netherlands

NARCIS (Netherlands)

Homan, J.; Bokkerink, G.M.J.; Aarts, M.J.; Lemmens, V.E.; Lijnschoten, G. van; Rutten, H.J.; Wijsman, J.H.; Nagtegaal, I.D.; Wilt, J.H.W. de

2015-01-01

BACKGROUND: Since the introduction of total mesorectal surgery the outcome of rectal cancer patients has improved significantly. Involvement of the circumferential resection margin (CRM) is an important predictor of increased local recurrence, distant metastases and decreased overall survival.

Localized gastrointestinal amyloidosis presenting with protein-losing enteropathy and massive hemorrhage

Directory of Open Access Journals (Sweden)

Bárbara Corrêa

Full Text Available Amyloidosis of the gastrointestinal tract is usually a systemic disease. Localized gastrointestinal amyloidosis without evidence of extraintestinal involvement or an associated plasma cell dyscrasia is uncommon and does not usually cause death. We report a case of a patient with localized gastrointestinal amyloidosis who presented with protein-losing enteropathy and a fatal upper gastrointestinal bleed.

Determination of the Support Level of Local Organizations in a Model Forest Initiative: Do Local Stakeholders Have Willingness to Be Involved in the Model Forest Development?

Directory of Open Access Journals (Sweden)

Ahmet Tolunay

2014-10-01

Full Text Available Voluntary cooperation and the support of stakeholders carry a major importance in the development of Model Forests. The identification of the support level of local organizations as stakeholders in the Bucak Model Forest initiative, located in the Mediterranean region of Turkey, constitutes the theme of this study. Within this scope, the views of the stakeholders comprising local government units (LGUs, non-governmental organizations (NGOs, village councils (VCs, professional organizations (POs and forest products enterprises (FPEs located in the district of Bucak were collected by utilizing a survey technique. The data were analysed by using non-parametric statistical analyses due to the absence of a normal distribution. The results show that the information provided about the Model Forest concept to the stakeholders located in the district on the Bucak Model Forest initiative was identified as a factor impacting the support level. Moreover, it was also observed that the stakeholders were more willing to provide advisory support rather than financial support. NGOs and VCs were identified as stakeholders who could not provide financial support due to their restricted budgets. We discuss the benefits for a Model Forest initiative of establishing international cooperation to strengthen the local and regional sustainable development process.

Stakeholder involvement in decommissioning nuclear facilities

International Nuclear Information System (INIS)

2007-01-01

Significant numbers of nuclear facilities will need to be decommissioned in the coming decades. In this context, NEA member countries are placing increasing emphasis on the involvement of stakeholders in the associated decision procedures. This study reviews decommissioning experience with a view to identifying stakeholder concerns and best practice in addressing them. The lessons learnt about the end of the facility life cycle can also contribute to better foresight in siting and building new facilities. This report will be of interest to all major players in the field of decommissioning, in particular policy makers, implementers, regulators and representatives of local host communities

Interferometric probes of many-body localization.

Science.gov (United States)

Serbyn, M; Knap, M; Gopalakrishnan, S; Papić, Z; Yao, N Y; Laumann, C R; Abanin, D A; Lukin, M D; Demler, E A

2014-10-03

We propose a method for detecting many-body localization (MBL) in disordered spin systems. The method involves pulsed coherent spin manipulations that probe the dephasing of a given spin due to its entanglement with a set of distant spins. It allows one to distinguish the MBL phase from a noninteracting localized phase and a delocalized phase. In particular, we show that for a properly chosen pulse sequence the MBL phase exhibits a characteristic power-law decay reflecting its slow growth of entanglement. We find that this power-law decay is robust with respect to thermal and disorder averaging, provide numerical simulations supporting our results, and discuss possible experimental realizations in solid-state and cold-atom systems.

Involving, Sharing, Analysing—Potential of the Participatory Photo Interview

Directory of Open Access Journals (Sweden)

Bettina Kolb

2008-09-01

Full Text Available This article discusses the photo interview method used in a participatory inter- and transdisciplinary research setting. The photo interview has proven particularly useful for sustainability and environmental studies in which eliciting community points of view is crucial to the research effort. Based on experiences in several countries, the author describes and analyses the photo interview process and its three phases—involving, sharing and analysing—and explores potential influences on data quality. In the first phase, researchers use the photo interview method to involve community residents from different levels of society in the research process. In the second phase, the photo interview method encourages community residents and scientists to share insights and perspectives and to partner in developing a common understanding of local structures, processes, and possible solutions. In the third phase, the photo interview method allows researchers to analyse visual and textual data as a representation of a local societal context. In decoding images, researchers ground the analysis in subjective perspectives, use residents' visual codes along with other methods to further analyse community data, and explore the wider societal context in which the study is embedded. URN: urn:nbn:de:0114-fqs0803127

Private Sector Involvement in Urban Solid Waste Collection: Performance, Capacity, and Regulation in Five Cities in Ghana

NARCIS (Netherlands)

Oduro-Kwarteng, S.

2011-01-01

This book exposes the inefficiencies in private sector provision and lack of capacity of Local Governments to deal with solid waste collection. The book will be essential for students, researchers and practitioners involved in areas such as policy, markets, local governments, environmental

Primary laryngeal localization of multiple myeloma: A case report

OpenAIRE

Allegra, Eugenia; Marino, Nicol?; Modica, Domenico; Emmanuele, Carmela; Saita, Vincenzo

2017-01-01

Multiple myeloma is a lymphoproliferative disease that may involve the bone marrow as well as extramedullary soft tissues. However, laryngeal localization of multiple myeloma is extremely rare. We herein present the case of a 68-year-old male patient with a history of dyspnea, dysphonia and dysphagia. Laryngoscopic examination revealed a lesion involving the right glottis and right vestibular (false) vocal fold, with absence of ipsilateral laryngeal motility and constriction of the airway. Co...

PLD$ is involved in phagocytosis of microglia: expression and localization changes of PLD4 are correlated with activation state of microglia.

Directory of Open Access Journals (Sweden)

Yoshinori Otani

Full Text Available Phospholipase D4 (PLD4 is a recently identified protein that is mainly expressed in the ionized calcium binding adapter molecule 1 (Iba1-positive microglia in the early postnatal mouse cerebellar white matter. Unlike PLD1 and PLD2, PLD4 exhibits no enzymatic activity for conversion of phosphatidylcholine into choline and phosphatidic acid, and its function is completely unknown. In the present study, we examined the distribution of PLD4 in mouse cerebellar white matter during development and under pathological conditions. Immunohistochemical analysis revealed that PLD4 expression was associated with microglial activation under such two different circumstances. A primary cultured microglia and microglial cell line (MG6 showed that PLD4 was mainly present in the nucleus, except the nucleolus, and expression of PLD4 was upregulated by lipopolysaccharide (LPS stimulation. In the analysis of phagocytosis of LPS-stimulated microglia, PLD4 was co-localized with phagosomes that contained BioParticles. Inhibition of PLD4 expression using PLD4 specific small interfering RNA (siRNA in MG6 cells significantly reduced the ratio of phagocytotic cell numbers. These results suggest that the increased PLD4 in the activation process is involved in phagocytosis of activated microglia in the developmental stages and pathological conditions of white matter.

Prediction of Chlamydia pneumoniae protein localization in host mitochondria and cytoplasm and possible involvements in lung cancer etiology: a computational approach

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Aws Alshamsan

2017-12-01

Full Text Available Collecting evidence suggests that the intercellular infection of Chlamydia pneumoniae in lungs contributes to the etiology of lung cancer. Many proteins of Chlamydia pneumoniae outmanoeuvre the various system of the host. The infection may regulate various factors, which can influence the growth of lung cancer in affected persons. In this in-silico study, we predict potential targeting of Chlamydia pneumoniae proteins in mitochondrial and cytoplasmic comportments of host cell and their possible involvement in growth and development of lung cancer. Various cellular activities are controlled in mitochondria and cytoplasm, where the localization of Chlamydia pneumoniae proteins may alter the normal functioning of host cells. The rationale of this study is to find out and explain the connection between Chlamydia pneumoniae infection and lung cancer. A sum of 183 and 513 proteins were predicted to target in mitochondria and cytoplasm of host cell out of total 1112 proteins of Chlamydia pneumoniae. In particular, many targeted proteins may interfere with normal growth behaviour of host cells, thereby altering the decision of program cell death. Present article provides a potential connection of Chlamydia pneumoniae protein targeting and proposed that various targeted proteins may play crucial role in lung cancer etiology through diverse mechanisms.

Local politics, conflict and development in Peruvian mining regions

OpenAIRE

Arellano-Yanguas, Javier

2011-01-01

This thesis examines the effects of a collection of policies that determine the\\ud mandatory distribution of mining, gas and oil revenues between national and subnational\\ud governments, and the greater involvement of mining companies in local\\ud development. I have labelled this set of policies, which aims to reduce social\\ud conflict and promote local development, the New Extractive Industry Strategy\\ud (NEIS).\\ud \\ud Chapter 1 describes the implementation of these policies in Peru and high...

Unravelling networks in local public health policymaking in three European countries - a systems analysis.

Science.gov (United States)

Spitters, Hilde P E M; Lau, Cathrine J; Sandu, Petru; Quanjel, Marcel; Dulf, Diana; Glümer, Charlotte; van Oers, Hans A M; van de Goor, Ien A M

2017-02-03

Facilitating and enhancing interaction between stakeholders involved in the policymaking process to stimulate collaboration and use of evidence, is important to foster the development of effective Health Enhancing Physical Activity (HEPA) policies. Performing an analysis of real-world policymaking processes will help reveal the complexity of a network of stakeholders. Therefore, the main objectives were to unravel the stakeholder network in the policy process by conducting three systems analyses, and to increase insight into the similarities and differences in the policy processes of these European country cases. A systems analysis of the local HEPA policymaking process was performed in three European countries involved in the 'REsearch into POlicy to enhance Physical Activity' (REPOPA) project, resulting in three schematic models showing the main stakeholders and their relationships. The models were used to compare the systems, focusing on implications with respect to collaboration and use of evidence in local HEPA policymaking. Policy documents and relevant webpages were examined and main stakeholders were interviewed. The systems analysis in each country identified the main stakeholders involved and their position and relations in the policymaking process. The Netherlands and Denmark were the most similar and both differed most from Romania, especially at the level of accountability of the local public authorities for local HEPA policymaking. The categories of driving forces underlying the relations between stakeholders were formal relations, informal interaction and knowledge exchange. A systems analysis providing detailed descriptions of positions and relations in the stakeholder network in local level HEPA policymaking is rather unique in this area. The analyses are useful when a need arises for increased interaction, collaboration and use of knowledge between stakeholders in the local HEPA network, as they provide an overview of the stakeholders involved and

FINANCIAL MANAGEMENT AND LOCAL ECONOMIC DEVELOPMENT AN ALTERNATIVE FOR NEW FUNDING SOURCES OF THE LOCAL COMMUNITIES

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Filip Petru

2010-12-01

Full Text Available This paper intends to answer mainly the questions: What are the consequences of the taxation base increase? What forms does the taxation base have? What can local authorities do in order to make certain areas attractive? Which are the specific players involved in the local economic development? Also, beyond the rigours imposed by the mathematical presentation of the sustainable economic development, we appreciate that for the financial management, too, knowing the gear determined by the allocation of public resources and generation of additional revenues will be very useful in establishing and underlying the decisions to invest in the public infrastructure and, also, to calculate the time period in which these can be depreciated especially based on the financial flows from supplementary revenues.

A realistic model for quantum theory with a locality property

International Nuclear Information System (INIS)

Eberhard, P.H.

1987-04-01

A model reproducing the predictions of relativistic quantum theory to any desired degree of accuracy is described in this paper. It involves quantities that are independent of the observer's knowledge, and therefore can be called real, and which are defined at each point in space, and therefore can be called local in a rudimentary sense. It involves faster-than-light, but not instantaneous, action at distance

Multifocal Langerhans cell sarcoma involving epidermis: a case report and review

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Wang Changsong

2012-08-01

Full Text Available Abstract Objective To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS which involving epidermis. Methods A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. Results A 41-year-old man with multifocal cutaneous LCS involving the inguina and waist was reported. Clinical and pathology data were available. Neoplastic cells with markedly malignant cytological features were observed. Tumor cells exhibited irregular shape with abundant and eosinophilic red staining cytoplasm; large, irregular-shaped, showing lobulated or dented nucleus and some cells with a longitudinal nuclear groove and prominent nucleoli. The tumor cells expressed CD1a, Langerin (CD207, S-100 protein, CD68 and vimentin, and did not express pan-T or B cell markers and epithelial markers. The patient died less than 1 year after diagnosis due to local recurrence and metastasis to the lung, despite the administration of local radiation and chemotherapy. Conclusions LCS is a tumor with markedly malignant cytological features that originates from Langerhans cells. Primary multifocal neoplasms involving epidermis is even rare. Accurate diagnosis is based on the histopathological and immunohistochemical of the tumor cells. Virtual slide The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1182345104754765.

Mermin Non-Locality in Abstract Process Theories

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Stefano Gogioso

2015-11-01

Full Text Available The study of non-locality is fundamental to the understanding of quantum mechanics. The past 50 years have seen a number of non-locality proofs, but its fundamental building blocks, and the exact role it plays in quantum protocols, has remained elusive. In this paper, we focus on a particular flavour of non-locality, generalising Mermin's argument on the GHZ state. Using strongly complementary observables, we provide necessary and sufficient conditions for Mermin non-locality in abstract process theories. We show that the existence of more phases than classical points (aka eigenstates is not sufficient, and that the key to Mermin non-locality lies in the presence of certain algebraically non-trivial phases. This allows us to show that fRel, a favourite toy model for categorical quantum mechanics, is Mermin local. We show Mermin non-locality to be the key resource ensuring the device-independent security of the HBB CQ (N,N family of Quantum Secret Sharing protocols. Finally, we challenge the unspoken assumption that the measurements involved in Mermin-type scenarios should be complementary (like the pair X,Y, opening the doors to a much wider class of potential experimental setups than currently employed. In short, we give conditions for Mermin non-locality tests on any number of systems, where each party has an arbitrary number of measurement choices, where each measurement has an arbitrary number of outcomes and further, that works in any abstract process theory.

Can EPR non-locality be geometrical?

International Nuclear Information System (INIS)

Ne'eman, Y.

1995-01-01

The presence in Quantum Mechanics of non-local correlations is one of the two fundamentally non-intuitive features of that theory. The non-local correlations themselves fall into two classes: EPR and Geometrical. The non-local characteristics of the geometrical type are well-understood and are not suspected of possibly generating acausal features, such as faster-than-light propagation of information. This has especially become true since the emergence of a geometrical treatment for the relevant gauge theories, i.e. Fiber Bundle geometry, in which the quantum non-localities are seen to correspond to pure homotopy considerations. This aspect is reviewed in section 2. Contrary-wise, from its very conception, the EPR situation was felt to be paradoxical. It has been suggested that the non-local features of EPR might also derive from geometrical considerations, like all other non-local characteristics of QM. In[7], one of the authors was able to point out several plausibility arguments for this thesis, emphasizing in particular similarities between the non-local correlations provided by any gauge field theory and those required by the preservation of the quantum numbers of the original EPR state-vector, throughout its spatially-extended mode. The derivation was, however, somewhat incomplete, especially because of the apparent difference between, on the one hand, the closed spatial loops arising in the analysis of the geometrical non-localities, from Aharonov-Bohm and Berry phases to magnetic monopoles and instantons, and on the other hand, in the EPR case, the open line drawn by the positions of the two moving decay products of the disintegrating particle. In what follows, the authors endeavor to remove this obstacle and show that as in all other QM non-localities, EPR is somehow related to closed loops, almost involving homotopy considerations. They develop this view in section 3

Favorable Local Control From Consolidative Radiation Therapy in High-Risk Neuroblastoma Despite Gross Residual Disease, Positive Margins, or Nodal Involvement

Energy Technology Data Exchange (ETDEWEB)

Ferris, Matthew J., E-mail: mjferri@emory.edu [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Danish, Hasan [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Switchenko, Jeffrey M. [Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia (United States); Deng, Claudia [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); George, Bradley A.; Goldsmith, Kelly C.; Wasilewski, Karen J.; Cash, W. Thomas [Aflac Cancer and Blood Disorders Center, Children' s Healthcare of Atlanta, Atlanta, Georgia (United States); Khan, Mohammad K.; Eaton, Bree R.; Esiashvili, Natia [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States)

2017-03-15

Purpose: To report the influence of radiation therapy (RT) dose and surgical pathology variables on disease control and overall survival (OS) in patients treated for high-risk neuroblastoma at a single institution. Methods and Materials: We conducted a retrospective study of 67 high-risk neuroblastoma patients who received RT as part of definitive management from January 2003 until May 2014. Results: At a median follow-up of 4.5 years, 26 patients (38.8%) failed distantly; 4 of these patients also failed locally. One patient progressed locally without distant failure. Local control was 92.5%, and total disease control was 59.5%. No benefit was demonstrated for RT doses over 21.6 Gy with respect to local relapse–free survival (P=.55), disease-free survival (P=.22), or OS (P=.72). With respect to local relapse–free survival, disease-free survival, and OS, no disadvantage was seen for positive lymph nodes on surgical pathology, positive surgical margins, or gross residual disease. Of the patients with gross residual disease, 75% (6 of 8) went on to have no evidence of disease at time of last follow-up, and the 2 patients who failed did so distantly. Conclusions: Patients with high-risk neuroblastoma in this series maintained excellent local control, with no benefit demonstrated for radiation doses over 21.6 Gy, and no disadvantage demonstrated for gross residual disease after surgery, positive surgical margins, or pathologic lymph node positivity. Though the limitations of a retrospective review for an uncommon disease must be kept in mind, with small numbers in some of the subgroups, it seems that dose escalation should be considered only in exceptional circumstances.

Operation of the Selected Local Action Group

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Lukáš Nevěděl

2015-01-01

Full Text Available The main objective of this article is to compare the current operation of elected local action group with the concept of learning regions. This comparison is built on detailed knowledge and understanding of the operation of local action group Podbrnensko citizens’ association (Podbrnensko CA and learning regions in general. The following is assumed: the understanding of community-based processes from the perspective of residents, the important stakeholders who influence the operation of communities or locations. The operation of local action groups is in line with the current concept led by local community development (community led local development, CLLD, which uses elements of the LEADER method. In this method the solution of development problems comes primarily from the inside, not from the outside of the studied territory. The methods used for the collection of empirical data were mostly observation and interviews with all partners involved in LAG (31 people, all mayors in LAG (29 people and 176 people from region, i.e. methods, which result in so called deep data. Between the primary techniques applied in the research are: participant observation, unstructured or semi-structured interviews and public debates.

Private Sector Involvement in Urban Solid Waste Collection. Performance, capacity and regulations in five cities in Ghana

NARCIS (Netherlands)

S. Oduro-Kwarteng (Sampson)

2011-01-01

textabstractThis thesis focuses on the private sector involvement in solid waste collection, and the influence of private sector capacity and local governments‘ regulations on private sector performance. Private sector involvement in public service pro-vision evolved to deal with market and

Preserving Local Culture through Digital Comics

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Tri Mulyati

2018-02-01

Full Text Available Digital environment offers teachers and students with a plethora of information and resources for learning. Nowadays, students who are mostly digital natives are used to utilizing technology in their daily life. This condition should make teachers as technology leaders responsible to provide a good learning environment where the students are involved in their own learning and that best suits to them in in a particular context. Therefore, this study aimed at developing local culture based digital comics for narrative reading comprehension and inserting local culture of Banyuwangi in English language teaching. This study followed the research and development design adapting the pattern developed by Borg and Gall. Based on the result of need analysis administered to students in class VIII of SMPN 1 Kalipuro, Banyuwangi, the product were developed by inserting local culture content into narrative texts in the form of digital comics. The digital comics had two titles: The Dance Competition and The Legend of Banyuwangi. The product was validated by the experts and tried out to the students. The result showed that the local culture based digital comics were applicable to be used in the teaching and learning narrative text reading comprehension.

Democratizing Process Innovation? On Citizen Involvement in Public Sector BPM

Science.gov (United States)

Niehaves, Björn; Malsch, Robert

‘Open Innovation’ has been heavily discussed for product innovations; however, an information systems (IS) perspective on ‘process innovation’ has not yet been taken. Analyzing the example of the public sector in Germany, the paper seeks to investigate the factors that hinder and support ‘open process innovation’, a concept we define as the involvement of citizens in business process management (BPM) activities. With the help of a quantitative study (n=358), six factors are examined for their impact on citizen involvement in local government BPM initiatives. The results show that citizen involvement in reform processes is not primarily motivated by the aim of cost reduction, but rather related to legitimacy reasons and the intent to increase employee motivation. Based on these findings, implications for (design) theory and practice are discussed: Instead of detailed collaborative business processes modeling, the key of citizen involvement in public sector BPM lies in communication and mutual understanding.

The evolution of local participation and the mode of knowledge production in Arctic research

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Nicolas D. Brunet

2014-06-01

Full Text Available Arctic science is often claimed to have been transformed by the increased involvement of local people, but these claims of a new research paradigm have not been empirically evaluated. We argue that the "new" participatory research paradigm emerging in Arctic science embodies many of the principles of the Mode 2 knowledge production framework. Using the Mode 2 thesis as an assessment framework, we examined research articles appearing between 1965 and 2010 in the journal Arctic to assess the extent to which there has been a paradigm shift toward more participatory approaches. Results suggest that the involvement of local people has increased only slightly over the last half century and continues to vary systematically among disciplines, organizations, and regions. Analysis of three additional journals focused on Arctic and circumpolar science establishes the generality of these slight increases in local involvement. There is clearly room for more community involvement in Arctic science, but achieving this will require either increasing the proportional representation of the organizations, disciplines, and regions with a track record of successful Mode 2 research, or encouraging Mode 2 research innovation within the organizations, disciplines, and regions currently predominated by Mode 1 approaches.

Breast cancer with axillary lymph node involvement

International Nuclear Information System (INIS)

Belaid, A.; Kanoun, S.; Kallel, A.; Ghorbel, I.; Azoury, F.; Heymann, S.; Marsiglia, H.; Bourgier, C.; Belaid, A.; Ghorbel, I.; Kanoun, S.; Kallel, A.; Pichenot, C.; Verstraet, R.; Marsiglia, H.

2010-01-01

Breast cancer is the most frequent cancer of women in western countries. There are one million new cases per year in the world which represents 22% of all female cancers, and more than 370.000 deaths due to breast cancer per year (14% of cancer mortality). More than half of breast cancers are associated with axillary nodal involvement. Post-operative radiation therapy (XRT) is a crucial part of locoregional treatment in axillary nodal involvement breast cancer owing to a 15-years risk reduction of locoregional recurrence of 70% and to a 5.4% risk reduction of specific mortality. In 3D-conformal irradiation in such breast cancers, target volumes are chest wall when mastectomy was performed or breast and boost of tumor bed in case of breast conservative surgery, and supra-clavicular and/or axillary and/or internal mammary node areas. The main organs at risk are ipsilateral lung, heart and brachial plexus. The aim of this article is to describe epidemiologic, radio anatomic and prognostic features of axillary nodal involvement breast cancer and to propose guidelines for 3D-conformal treatment planning in locally advanced breast cancers. This review is illustrated by a case report. (authors)

Involvement of local stakeholders in the development of new information schemes for the displaying of environmental radiological monitoring results

International Nuclear Information System (INIS)

Rollinger, Francoise; Lebeau, Audrey; Petitfrere, Michael; Eimer, Michel; Ganay, Claude de; Gadbois, Serge; Leprieur, Fabrice; Vaillant, Ludovic

2008-01-01

Evolution of radionuclides concentration in the environment and associated potential health impacts are key and legitimate questions for the population living around nuclear facilities. In spite of the efforts from authorities, public experts and operators to make this information available and understandable, mainly through Local Liaison Committees (LLC), the way it is usually formalized makes it difficult to meet non-expert expectations. In this context, the IRSN launched a pilot project in the Loire Valley to define new schemes for the displaying of this information. This project brings together representatives from LLCs - local elected people, trade unions and environmental NGOs -, experts from the IRSN - environment and radiation protection departments - and facilitators - CEPN and MUTADIS -. Its objectives are: 1-) To identify all nuclear facilities and producers of measurements in the environment within the Valley; 2-) To clearly define local population expectations regards environmental radiological survey; 3-) To select adequate measurements values and presentational schemes; 4-) To provide recommendations regarding the environment monitoring strategy. This project is also connected with the French national measurement network. Within this national network, the IRSN is in charge of developing a database that brings together all the results from environmental radiological monitoring, in order to provide all these data to the population, including elements about impacts on human health. This network will take advantage of the work achieved within the pilot project. The facilitation process mainly consisted in fostering relations of trust (notably with the preparation of detailed minutes of the project meetings), and supporting both local stakeholders and IRSN experts in the project management and the development of a common language at the crossroad between scientific and technical knowledge and local actors' understanding of their own environment. This

Local Agenda 21 and sustainable development: The case of Harran, Turkey

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Reyhan Genli Yiğiter

2011-01-01

Full Text Available The twenty-first century is the beginning of an era in which urban development at the international and national levels, equality, continuity, capability, administration involving many actors and settlement systems need to be dealt with using new settlement administration ethics. The concept of sustainable development first came up at the National Development and Environment Conference held in 1992 in Rio de Janeiro, when the action plan known as Agenda 21 was constituted at the Earth Summit. This is a comprehensive document assigning responsibility to governments, NGOs, local authorities, United Nations organisations, development organisations and all persons and institutions that have an impact on the environment. On this basis, this study evaluates the growing necessity of urban transformation in Turkey in various dimensions within the framework of Local Agenda 21, in which various actors can be involved. This paper approaches the issues not only from the point of view of the state, but also from the point of view of all actors to whom responsibility is assigned. It examines the philosophy of the Local Agenda 21 program and how it is being implemented in the Municipality of Harran, and it assesses the achievement level of Local Agenda 21 in Turkey and policies in the case reviewed. The paper includes proposals that will allow all local authorities in Turkey to examine their own programs within the framework of the Local Agenda 21 action program so that they can participate in the urban transformation process, develop local sustainable development policies and establish short-term and long-term strategic plans to solve problems.

Is sonic Hedgehog involved in human fracture healing? --a prospective study on local and systemic concentrations of SHH.

Science.gov (United States)

Eipeldauer, Stefan; Thomas, Anita; Hoechtl-Lee, Leonard; Kecht, Mathias; Binder, Harald; Koettstorfer, Julia; Gregori, Markus; Sarahrudi, Kambiz

2014-01-01

Sonic Hedgehog (SHH) is a new signalling pathway in bone repair. Evidence exist that SHH pathway plays a significant role in vasculogenesis and limb development during embryogenesis. Some in vitro and animal studies has already proven its potential for bone regeneration. However, no data on the role of SHH in the human fracture healing have been published so far. Seventy-five patients with long bone fractures were included into the study and divided in 2 groups. First group contained 69 patients with normal fracture healing. Four patients with impaired fracture healing formed the second group. 34 volunteers donated blood samples as control. Serum samples were collected over a period of 1 year following a standardized time schedule. In addition, SHH levels were measured in fracture haematoma and serum of 16 patients with bone fractures. Fracture haematoma and patients serum both contained lower SHH concentrations compared to control serum. The comparison between the patients' serum SHH level and the control serum revealed lower levels for the patients at all measurement time points. Significantly lower concentrations were observed at weeks 1 and 2 after fracture. SHH levels were slightly decreased in patients with impaired fracture healing without statistical significance. This is the first study to report local and systemic concentration of SHH in human fracture healing and SHH serum levels in healthy adults. A significant reduction of the SHH levels during the inflammatory phase of fracture healing was found. SHH concentrations in fracture haematoma and serum were lower than the concentration in control serum for the rest of the healing period. Our findings indicate that there is no relevant involvement of SHH in human fracture healing. Fracture repair process seem to reduce the SHH level in human. Further studies are definitely needed to clarify the underlying mechanisms.

Women care about local knowledge, experiences from ethnomycology

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Garibay-Orijel Roberto

2012-07-01

Full Text Available Abstract Gender is one of the main variables that influence the distribution of local knowledge. We carried out a literature review concerning local mycological knowledge, paying special attention to data concerning women’s knowledge and comparative gender data. We found that unique features of local mycological knowledge allow people to successfully manage mushrooms. Women are involved in every stage of mushroom utilization from collection to processing and marketing. Local mycological knowledge includes the use mushrooms as food, medicine, and recreational objects as well as an aid to seasonal household economies. In many regions of the world, women are often the main mushroom collectors and possess a vast knowledge about mushroom taxonomy, biology, and ecology. Local experts play a vital role in the transmission of local mycological knowledge. Women participate in the diffusion of this knowledge as well as in its enrichment through innovation. Female mushroom collectors appreciate their mycological knowledge and pursue strategies and organization to reproduce it in their communities. Women mushroom gatherers are conscious of their knowledge, value its contribution in their subsistence systems, and proudly incorporate it in their cultural identity.

Resonance fluorescence microscopy via three-dimensional atom localization

Science.gov (United States)

Panchadhyayee, Pradipta; Dutta, Bibhas Kumar; Das, Nityananda; Mahapatra, Prasanta Kumar

2018-02-01

A scheme is proposed to realize three-dimensional (3D) atom localization in a driven two-level atomic system via resonance fluorescence. The field arrangement for the atom localization involves the application of three mutually orthogonal standing-wave fields and an additional traveling-wave coupling field. We have shown the efficacy of such field arrangement in tuning the spatially modulated resonance in all directions. Under different parametric conditions, the 3D localization patterns originate with various shapes such as sphere, sheets, disk, bowling pin, snake flute, flower vase. High-precision localization is achieved when the radiation field detuning equals twice the combined Rabi frequencies of the standing-wave fields. Application of a traveling-wave field of suitable amplitude at optimum radiation field detuning under symmetric standing-wave configuration leads to 100% detection probability even in sub-wavelength domain. Asymmetric field configuration is also taken into consideration to exhibit atom localization with appreciable precision compared to that of the symmetric case. The momentum distribution of the localized atoms is found to follow the Heisenberg uncertainty principle under the validity of Raman-Nath approximation. The proposed field configuration is suitable for application in the study of atom localization in an optical lattice arrangement.

Human–wildlife conflict and attitude of local people towards ...

African Journals Online (AJOL)

Human–wildlife conflict is a serious challenge undermining the integrity of protected areas in developing countries. Developing effective human–wildlife conflict mitigation strategies requires an understanding of the conflict patterns, species involved and attitudes of local people living along protected area boundaries.

IMMUNOLOGICAL MECHANISMS OF LOCAL INFLAMMATION

OpenAIRE

V. A. Chereshnev; M. V. Chereshneva

2011-01-01

Abstract.  The  lecture  presents  current  data,  as  well  as  authors’  view  to  the  issue  of  immune  system involvement into inflammation. General physiological principles of immune system functioning are considered in details. Immunological mechanisms of local inflammation and participation of immune system components are analyzed with regard of protective/adaptive reactions in inflammatory foci. Original formulations of basic concepts are presented from the viewpoint of pathophysiol...

Localized scleroderma: imaging features

International Nuclear Information System (INIS)

Liu, P.; Uziel, Y.; Chuang, S.; Silverman, E.; Krafchik, B.; Laxer, R.

1994-01-01

Localized scleroderma is distinct from the diffuse form of scleroderma and does not show Raynaud's phenomenon and visceral involvement. The imaging features in 23 patients ranging from 2 to 17 years of age (mean 11.1 years) were reviewed. Leg length discrepancy and muscle atrophy were the most common findings (five patients), with two patients also showing modelling deformity of the fibula. One patient with lower extremity involvement showed abnormal bone marrow signals on MR. Disabling joint contracture requiring orthopedic intervention was noted in one patient. In two patients with ''en coup de sabre'' facial deformity, CT and MR scans revealed intracranial calcifications and white matter abnormality in the ipsilateral frontal lobes, with one also showing migrational abnormality. In a third patient, CT revealed white matter abnormality in the ipsilateral parietal lobe. In one patient with progressive facial hemiatrophy, CT and MR scans showed the underlying hypoplastic left maxillary antrum and cheek. Imaging studies of areas of clinical concern revealed positive findings in half our patients. (orig.)

Adapting Mobile Beacon-Assisted Localization in Wireless Sensor Networks

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Wei Dong

2009-04-01

Full Text Available The ability to automatically locate sensor nodes is essential in many Wireless Sensor Network (WSN applications. To reduce the number of beacons, many mobile-assisted approaches have been proposed. Current mobile-assisted approaches for localization require special hardware or belong to centralized localization algorithms involving some deterministic approaches due to the fact that they explicitly consider the impreciseness of location estimates. In this paper, we first propose a range-free, distributed and probabilistic Mobile Beacon-assisted Localization (MBL approach for static WSNs. Then, we propose another approach based on MBL, called Adapting MBL (A-MBL, to increase the efficiency and accuracy of MBL by adapting the size of sample sets and the parameter of the dynamic model during the estimation process. Evaluation results show that the accuracy of MBL and A-MBL outperform both Mobile and Static sensor network Localization (MSL and Arrival and Departure Overlap (ADO when both of them use only a single mobile beacon for localization in static WSNs.

Adapting mobile beacon-assisted localization in wireless sensor networks.

Science.gov (United States)

Teng, Guodong; Zheng, Kougen; Dong, Wei

2009-01-01

The ability to automatically locate sensor nodes is essential in many Wireless Sensor Network (WSN) applications. To reduce the number of beacons, many mobile-assisted approaches have been proposed. Current mobile-assisted approaches for localization require special hardware or belong to centralized localization algorithms involving some deterministic approaches due to the fact that they explicitly consider the impreciseness of location estimates. In this paper, we first propose a range-free, distributed and probabilistic Mobile Beacon-assisted Localization (MBL) approach for static WSNs. Then, we propose another approach based on MBL, called Adapting MBL (A-MBL), to increase the efficiency and accuracy of MBL by adapting the size of sample sets and the parameter of the dynamic model during the estimation process. Evaluation results show that the accuracy of MBL and A-MBL outperform both Mobile and Static sensor network Localization (MSL) and Arrival and Departure Overlap (ADO) when both of them use only a single mobile beacon for localization in static WSNs.

Predicting the subcellular localization of viral proteins within a mammalian host cell

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Thomas DY

2006-04-01

Full Text Available Abstract Background The bioinformatic prediction of protein subcellular localization has been extensively studied for prokaryotic and eukaryotic organisms. However, this is not the case for viruses whose proteins are often involved in extensive interactions at various subcellular localizations with host proteins. Results Here, we investigate the extent of utilization of human cellular localization mechanisms by viral proteins and we demonstrate that appropriate eukaryotic subcellular localization predictors can be used to predict viral protein localization within the host cell. Conclusion Such predictions provide a method to rapidly annotate viral proteomes with subcellular localization information. They are likely to have widespread applications both in the study of the functions of viral proteins in the host cell and in the design of antiviral drugs.

Hydatid disease localized in mesorectum: Case report

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Abdullah Oğuz

2015-03-01

Full Text Available Hydatid disease is a parasitic disease, which is caused by echinococcus and often located in the liver and lung but occasionally found in other organs. Only one previous study reported localization in the mesorectum. In this case report, we present a 27-year-old male, as a second case in the literature, with a hydatid cyst located in the mesorectum. Abdominopelvic computed tomography revealed cystic masses localized in the mesorectum with no pulmonary or hepatic involvement. Preoperative cyst hydatid IgG (1/1000 was positive, and the preliminary diagnosis was hydatid disease. The patient underwent partial cystectomy. Macroscopic and microscopic examination of the specimens confirmed the hydatid cyst. This case report demonstrates that hydatid disease should be taken into consideration in the differential diagnosis of a cystic mass in any anatomic localization, especially in endemic areas. J Clin Exp Invest 2015; 6 (1: 75-77

The Capacity and Institution Building (CIB Working Group of United Cities and Local Governments: Towards Improving Aid Effectiveness in the Local Government Sector

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Tim Kehoe

2009-11-01

Full Text Available The United Cities and Local Governments (UCLG Capacity and Institution Building (CIB Working Group gather together professional practitioners of local government associations (LGAs and individual local governments active in international cooperation, with the overall objective to improve the quality, coordination and alignment of their development cooperation interventions. The Working Group is the successor of the CIB Platform, which existed for many years within the former International Union of Local Authorities (IULA as an informal gathering of staff members of local government associations (LGAs involved in the field of municipal international cooperation (MIC and association capacity building (ACB. In addition to information exchange, the CIB Platform undertook specific initiatives such as a World Bank-funded program supporting ACB in several countries. In May 2004, the CIB was integrated into the structures of the newly-founded UCLG organisation, and its membership was expanded to also include staff members of international departments of cities active in international cooperation.

The energy transition: new dialogues between cities and local stakeholders. Exploratory study

International Nuclear Information System (INIS)

Saxer, Olivia; Lacassagne, Sylvie; Guerin, Laura; Dupas, Stephane

2016-01-01

Energy Cities has carried out an exploratory study for cities and diverse project leaders desiring to start a sustainable energy transition in collaboration with all stakeholders in their territory. Local authorities have a key role to play in climate and energy policies and in the energy transition towards a low carbon, energy efficient and sustainable society. However, they cannot act alone. They often control only a small percentage of the emissions of local greenhouse gases directly, and this percentage rarely exceeds a quarter. It is therefore necessary to rely on the involvement of local stakeholders, which in turn will provide an opportunity for these stakeholders to be ambitious through innovative actions. How to stimulate stakeholders' involvement? In the past several years, a number of citizens', economic actors' or other local actors' initiatives have contributed to the energy transition of territories. These initiatives are based on empowerment. For instance, stakeholders can get access and the power to act on innovative tools and approaches, such as social economy, stakeholders' participation, crowd-funding, renewable energy citizen cooperatives and fab labs. Two primary questions to explore: As coordinators and pilots of local strategies for energy transition, how can local authorities foster, identify, support and replicate local energy transition initiatives? What dialogue should local authorities and leaders of local initiatives engage in? How can they drive new modes of governance, where stakeholders share responsibility to co-develop public policies, manage their city, and encourage the energy transition at the local level? We selected more than ten European energy transition initiatives, as diverse as they are innovative, anticipating new forms of governance and new ways to act and collaborate. The exploratory study does not only describe their process but it also analyses the synergies between the different stakeholders and the role the

Who and What Does Involvement Involve?

DEFF Research Database (Denmark)

Hansen, Jeppe Oute; Petersen, Anders; Huniche, Lotte

2015-01-01

This article gives an account of aspects of a multi-sited field study of involvement of relatives in Danish psychiatry. By following metaphors of involvement across three sites of the psychiatric systema family site, a clinical site and a policy sitethe first author (J.O.) investigated how...... theoretical perspective laid out by Ernesto Laclau and Chantal Mouffe, the aim of this study is to show how the dominant discourse about involvement at the political and clinical sites is constituted by understandings of mentally ill individuals and by political objectives of involvement. The analysis...... the responsibility toward the mental health of the ill individual as well as toward the psychological milieu of the family....

Paving the Way for Heat. Local Government Policies for Developing Bioenergy

Directory of Open Access Journals (Sweden)

Bente Johnsen Rygg

2014-06-01

Full Text Available Local governments play dual roles in developing renewable energy projects. They are the targets of many goals concerning energy and climate, set by national and international actors, and they are important actors in energy planning, regulation setting, and the development of infrastructure and residential areas. In this paper, I study how local governments’ technology policies affect the actual outcome of project development based on experiences from 14 local governments. Technology policies are studied from the perspective of Sørensen’s [1] four areas of concern: direct support of innovation, infrastructure, regulation (protection and standards and public engagement. I find that local governments use policy instruments within all four areas, and that the way local governments involves in the process of bioenergy development are surprisingly similar despite differences in location and size of both the local government and the project.

Public involvement in the dose reconstruction study: the colorado story

International Nuclear Information System (INIS)

Morin, Norma C.; Lockhart, Ann J.

2000-01-01

Public involvement was a critical component for building awareness, trust, and credibility for the dose reconstruction study for the Rocky Flats Nuclear Weapons Facility in Colorado. The research team developed a process to inform, involve, and encourage public participation over the nine-year study period. Key affected and interested groups with a legitimate stake in the study were identified and invited to identify concerns and offer suggestions for the study. In many cases, the public actually provided direction for the research. Many issues were studied more in-depth as result of public concern. Proactive community outreach was undertaken; quarterly public meetings and workshops were held to inform the public about the study's progress and to hear their comments. Quarterly newsletters were mailed to stake holders. A speaker's bureau was established and more than 50 presentations were made to 1,500 community members in various civic, business, neighborhood, and technical groups. Fact sheets, citizen summaries of technical reports, technical topic papers, and a video were developed to provide a complete overview of the studies and the findings at the conclusion of the project. The video was provided to local cable television stations, and publications were taken to local libraries. A web site was developed to allow the public to readily access information and to order technical reports. Public comments on draft technical reports were solicited; questions and concerns were addressed and investigated. The staff answered citizen calls, and the research team responded in writing to more than 200 issues raised by very concerned citizens. In addition, a citizen's group was formed in 1992 to conduct an independent study of plutonium levels found in soil samples collected around Rocky Flats. Made up of homeowners, public interest groups, local health departments, interested citizens, and Health Advisory Panel members, the committee arranged for sampling and analysis of

Coupling of nonlocal and local continuum models by the Arlequinapproach

KAUST Repository

Han, Fei; Lubineau, Gilles

2011-01-01

for the 'fine scale' description in which nonlocal interactions are considered to have non-negligible effects. Classical continuum mechanics only involving local contact forces is introduced for the rest of the structure where these nonlocal effects can

U.S. EPA Superfund Program's Policy for Community Involvement at Radioactively Contaminated Sites

International Nuclear Information System (INIS)

Carey, Pat; Walker, Stuart

2008-01-01

This paper describes the Superfund program's statutory requirements for community involvement. It also discusses the efforts the Superfund program has made that go beyond these statutory requirements to involve communities. The Environmental Protection Agency (EPA) implements the Superfund program under the authority of the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA). From the beginning of the Superfund program, Congress envisioned a role for communities. This role has evolved and expanded during the implementation of the Superfund program. Initially, the CERCLA statute had community involvement requirements designed to inform surrounding communities of the work being done at a site. CERCLA's provisions required 1) development of a community relations plan for each site, 2) establishment of information repositories near each site where all publicly available materials related to the site would be accessible for public inspection, 3) opportunities for the public to comment on the proposed remedy for each site and 4) development of a responsiveness summary responding to all significant comments received on the proposed remedy. In recognition of the need for people living near Superfund sites to be well-informed and involved with decisions concerning sites in their communities, SARA expanded Superfund's community involvement activities in 1986. SARA provided the authority to award Technical Assistance Grants (TAGs) to local communities enabling them to hire independent technical advisors to assist them in understanding technical issues and data about the site. The Superfund Community Involvement Program has sought to effectively implement the statutory community involvement requirements, and to go beyond those requirements to find meaningful ways to involve citizens in the cleanup of sites in their communities. We've structured our program around

Public/stakeholder involvement at two Department of Energy sites: Case studies

International Nuclear Information System (INIS)

Gray, R.H.

1995-01-01

Efforts to communicate the results of environmental studies and involve the public in environmental decisions have increased nationwide. Outreach efforts at two US Department of Energy sites (i.e., the Hanford Site in southeastern Washington State and the Pantex Plant in the Texas Panhandle) have used a broad spectrum of communications media, including technical articles (open literature and symposium publications, annual and topical reports); information brochures and fact sheets; video productions; interactive exhibits, presentations at scientific, technical, civic, and other public meetings; and proactive interactions with the news media and with local, state, federal, and other agencies. In addition, representatives of local communities now operate offsite environmental monitoring stations and Native Americans are involved in studying cultural resources, fisheries, and other issues at Hanford and a program to obtain environmental samples from neighbor's property is underway at the Pantex Plant. All major environmental programs, such as the multi-year effort to reconstruct past radiological doses to offsite human populations at Hanford, are now conducted with open public participation

Public/stakeholder involvement at two Department of Energy sites: Case studies

Energy Technology Data Exchange (ETDEWEB)

Gray, R.H. [Battelle Pantex, Amarillo, TX (United States)

1995-12-31

Efforts to communicate the results of environmental studies and involve the public in environmental decisions have increased nationwide. Outreach efforts at two US Department of Energy sites (i.e., the Hanford Site in southeastern Washington State and the Pantex Plant in the Texas Panhandle) have used a broad spectrum of communications media, including technical articles (open literature and symposium publications, annual and topical reports); information brochures and fact sheets; video productions; interactive exhibits, presentations at scientific, technical, civic, and other public meetings; and proactive interactions with the news media and with local, state, federal, and other agencies. In addition, representatives of local communities now operate offsite environmental monitoring stations and Native Americans are involved in studying cultural resources, fisheries, and other issues at Hanford and a program to obtain environmental samples from neighbor`s property is underway at the Pantex Plant. All major environmental programs, such as the multi-year effort to reconstruct past radiological doses to offsite human populations at Hanford, are now conducted with open public participation.

Pattern of failures in gastric cancer patients with lymph node involvement treated by surgery, intraoperative and external beam radiotherapy

International Nuclear Information System (INIS)

Glehen, O.; Peyrat, P.; Beaujard, A.C.; Chapet, O.; Romestaing, P.; Sentenac, I.; Francois, Y.; Vignal, J.; Gerard, J.P.; Gilly, F.N.

2003-01-01

Aims: High local failure rates in gastric cancer have been reported, up to 67%. To achieve a better local control, we evaluated intraoperative radiotherapy (IORT) and external beam radiotherapy (EBRT) in association with surgery for gastric cancer patients with lymph node involvement. We report here the analysis of the patterns of failure for patients involved in this IORT protocol. Material and methods: Forty-two positive lymph node (N+) gastric cancer patients were operated on (31 total, three subtotal and eight extended gastrectomies) with IORT procedure between 1985 and 1997 (33 males, nine females, mean age 61.3 years). IORT was focused on coeliac area (mean dose 15 Gy), followed by EBRT (46 Gy) in 36 patients. Ten patients were pN1 and 32 were pN2. A concurrent systemic chemotherapy (five Fluoro-Uracil and Cisplatinum) was performed in 14 patients. Results: One patient died postoperatively. Actuarial pN+ 10 year survival rate was 44.8%. The 5 year actuarial local control and disease-free survival rates were 78.8 and 47.5%, respectively. As far as patterns of failure were explored, 5 patients have a local coeliac recurrence (12%) and 12 have distant metastases with no evidence of coeliac recurrence. Conclusion: This retrospective analysis suggests a potential effect of IORT and/or EBRT in promoting local control and long-term survival in gastric cancer patients with lymph node involvement

Relativistic effects in local inertial frames including PPN effects

International Nuclear Information System (INIS)

Shahid-Saless, B.

1986-01-01

In this dissertation they use the concept of a generalized Fermi frame to describe the relativistic effects on a body placed in a local inertial frame of reference due to local and distant sources of gravitation. They have considered, in particular, a model, consisted of two spherically symmetric gravitating sources, moving in circular orbits around a common barycenter where one of the bodies is chosen to be the local and the other the distant one. This has been done in the Parametrized-Post-Newtonian formalism using the slow motion, weak field approximation. The PPN parameters used are γ, β, zeta 1 and zeta 2 . They show that the main relativistic effect on a local satellite is described by the Schwarzchild field of the local body and the nonlinear term corresponding to the self-interaction of the local source itself. There are also much smaller terms that are proportional to the product of the potentials of local and distant bodies and distant body's self interactions. The spatial axis of the local frame undergoes Geodetic precession. Effects involving the parameters zeta 1 and zeta 2 seem to be slightly too small to be observable at the present time. In addition they have found accelerations that vanish in the general relativity limit

Stakeholder involvement in Swedish nuclear waste management

International Nuclear Information System (INIS)

Elam, Mark; Sundqvist, Goeran

2006-09-01

This report concerning Swedish nuclear waste management has been produced as part of a cross national research project: CARL - A Social Science Research Project into the Effects of Stakeholder involvement on Decision-Making in Radioactive Waste Management. Besides Sweden, the participating countries are Belgium, Canada, Finland, Slovenia and United Kingdom. A social science research team, working for three years, is in the first phase conducting research in their own countries in order to produce 6 country reports. During the next years the focus will shift to comparisons of stakeholder involvement practices in the participating countries. The report addresses current practices of Swedish nuclear waste management and their historical development. The main focus is on past, current and emerging patterns of stakeholder involvement in the siting of a deep repository for the final disposal of Sweden's spent nuclear fuel. The general questions attended to in the report are: Who are the main stakeholders, and how have they emerged and gained recognition as such? What are the issues currently subject to stakeholder involvement and how have these been decided upon? How is stakeholder involvement organized locally and nationally and how has this changed over time? How has stakeholder involvement gained acceptance as an activity of value in the siting of major waste facilities? The report have attempted to show the development of stakeholder involvement in the siting of a final repository for Sweden's spent nuclear fuel as resembling something other than a straightforward linear process of improvement and refinement. Stakeholder involvement has developed, over the past 15 years or so, into something more like a patchwork of different shapes and forms. Some of the forces that may well contribute to the further elaboration of the patchwork of stakeholder involvement have been pointed out, contingently modifying once more its overall colour and orientation. Questions have been

Stakeholder involvement in Swedish nuclear waste management

Energy Technology Data Exchange (ETDEWEB)

Elam, Mark; Sundqvist, Goeran [Goeteborg Univ. (Sweden). Section for Science and Technology Studies

2006-09-15

This report concerning Swedish nuclear waste management has been produced as part of a cross national research project: CARL - A Social Science Research Project into the Effects of Stakeholder involvement on Decision-Making in Radioactive Waste Management. Besides Sweden, the participating countries are Belgium, Canada, Finland, Slovenia and United Kingdom. A social science research team, working for three years, is in the first phase conducting research in their own countries in order to produce 6 country reports. During the next years the focus will shift to comparisons of stakeholder involvement practices in the participating countries. The report addresses current practices of Swedish nuclear waste management and their historical development. The main focus is on past, current and emerging patterns of stakeholder involvement in the siting of a deep repository for the final disposal of Sweden's spent nuclear fuel. The general questions attended to in the report are: Who are the main stakeholders, and how have they emerged and gained recognition as such? What are the issues currently subject to stakeholder involvement and how have these been decided upon? How is stakeholder involvement organized locally and nationally and how has this changed over time? How has stakeholder involvement gained acceptance as an activity of value in the siting of major waste facilities? The report have attempted to show the development of stakeholder involvement in the siting of a final repository for Sweden's spent nuclear fuel as resembling something other than a straightforward linear process of improvement and refinement. Stakeholder involvement has developed, over the past 15 years or so, into something more like a patchwork of different shapes and forms. Some of the forces that may well contribute to the further elaboration of the patchwork of stakeholder involvement have been pointed out, contingently modifying once more its overall colour and orientation. Questions

A carbon finance fund for local communities: why? how? Study report

International Nuclear Information System (INIS)

Chung, Nicolas; Delbosc, Anais; Dupont, Marion; Leseur, Alexia

2013-09-01

This study aims at promoting practices of ecological and social transition and sustainable development for local communities, and at developing the North-South solidarity in terms of development and struggle against poverty on issues like access to water and sanitation, and access to electrification by means of renewable energies. The first part describes the role of voluntary offsetting within the carbon finance, gives an overview of the use of carbon finance by local communities. The second part discusses the involvement of local communities in decentralized cooperation for climate-energy projects. The third one reports the analysis of the main benefits and constraints of the implementation of a local carbon fund in relationship with a decentralized cooperation approach

Forest management in India. Local versus state control of forest resources

Energy Technology Data Exchange (ETDEWEB)

Wilk, J

1998-12-31

Degradation and substantial losses to India`s forests have prompted a change in existing forestry management strategy. The new approach includes recognition of local participation in forestry management schemes but state control over most decisions is still dominant. Seen in terms of a common property resource system, India`s forests lack many of the factors usually considered inherent to successful management programs. Though India`s latest Forest Act affords more local involvement in forestry management, there continues to be an apparent lack of rights for local management groups over decision-making and the resource itself. Can this system enable the required balance between state and local management of India`s forests? 24 refs, 1 tab

Forest management in India. Local versus state control of forest resources

Energy Technology Data Exchange (ETDEWEB)

Wilk, J.

1997-12-31

Degradation and substantial losses to India`s forests have prompted a change in existing forestry management strategy. The new approach includes recognition of local participation in forestry management schemes but state control over most decisions is still dominant. Seen in terms of a common property resource system, India`s forests lack many of the factors usually considered inherent to successful management programs. Though India`s latest Forest Act affords more local involvement in forestry management, there continues to be an apparent lack of rights for local management groups over decision-making and the resource itself. Can this system enable the required balance between state and local management of India`s forests? 24 refs, 1 tab

Toolkit for local decision makers aims to strengthen environmental sustainability

CSIR Research Space (South Africa)

Murambadoro, M

2011-11-01

Full Text Available Members of the South African Risk and Vulnerability Atlas were involved in a meeting aimed at the development of a toolkit towards improved integration of climate change into local government's integrated development planning (IDP) process....

FOP is a centriolar satellite protein involved in ciliogenesis.

Directory of Open Access Journals (Sweden)

Joanna Y Lee

Full Text Available Centriolar satellites are proteinaceous granules that are often clustered around the centrosome. Although centriolar satellites have been implicated in protein trafficking in relation to the centrosome and cilium, the details of their function and composition remain unknown. FOP (FGFR1 Oncogene Partner is a known centrosome protein with homology to the centriolar satellite proteins FOR20 and OFD1. We find that FOP partially co-localizes with the satellite component PCM1 in a cell cycle-dependent manner, similarly to the satellite and cilium component BBS4. As for BBS4, FOP localization to satellites is cell cycle dependent, with few satellites labeled in G1, when FOP protein levels are lowest, and most labeled in G2. FOP-FGFR1, an oncogenic fusion that causes a form of leukemia called myeloproliferative neoplasm, also localizes to centriolar satellites where it increases tyrosine phosphorylation. Depletion of FOP strongly inhibits primary cilium formation in human RPE-1 cells. These results suggest that FOP is a centriolar satellite cargo protein and, as for several other satellite-associated proteins, is involved in ciliogenesis. Localization of the FOP-FGFR1 fusion kinase to centriolar satellites may be relevant to myeloproliferative neoplasm disease progression.

Stakeholder involvement in other sectors. High Voltage Electricity Transmission. Case study: CO_2 capture and storage. Common misconceptions on stakeholder involvement - Reviewing deployment of RES

International Nuclear Information System (INIS)

Wolsink, Maarten; Komendantova, Nadejda; Kalaydjian, Francois

2017-01-01

Session 7 featured several speakers with expertise outside of the nuclear field. High-voltage electricity transmission and carbon capture and storage projects were presented by experts who study and advise on stakeholder involvement in such activities. The session chair provided an overview of stakeholder involvement fundamentals as applied to renewable energy projects. Though the presentations were on non-nuclear projects, the principles presented and discussed were clearly applicable in nuclear contexts as well. Mr Wolsink of University of Amsterdam re-framed the topic of the power supply system as a 'socio-technical system'. He identified three types or levels of societal acceptance for energy innovation: socio-political acceptance, market acceptance and community acceptance. This distinction highlights the different nature of questions, issues, set of actors and challenges that arise at different points or forums around energy infrastructure projects and why general favorability towards a technology does not translate into support of its local implementation. Societal acceptance probably cannot be acquired without meaningful involvement. Arnstein's 'ladder of citizen participation' was referenced by two session speakers. Mr Wolsink explained that inexperienced organisations may target 'consultation', thinking that this is real participation. However, consultation is a relatively low level of involvement which consists of gathering information or views, without promoting two-way dialogue (engagement) or committing to actual influence and indeed some degree of citizen power. He advised that simple consultation should be avoided unless the organisation finds that such stakeholder or public input is essential to the decision and intends to give it due account. The Barendrecht case on carbon capture and storage, as presented by Mr Kalaydjian of IFP Energies Nouvelles, illustrates the danger in overly restricting or compartmentalising stakeholder involvement. Ms

Preoperative evaluation of locally spreaded pelvic tumors

International Nuclear Information System (INIS)

Baramia, M.; Todua, F.; Gotsadze, D.; Khutulashvili, N.; Lashkhi, K.; Nadareishvili, A.

1998-01-01

Am of the study: preoperative evaluation of patients with locally advanced pelvic tumors subjected to pelvic exenteration. Determine operability to avoid explorative laparatomies, which cause serious complications in these patients. Evaluate condition of urinary system in case of this pathology. Materials and methods: 34 patients with locally advanced pelvic tumors where pelvic exenteration was attempted were studied. Along with other methods of diagnostic CT and MRI were performed. Results: In all patients secondary involvement of the urinary bladder was noted. In 30 patients CT and MR findings were confirmed (88,2%) intraoperatively and different types of pelvic organs exenteration were performed. In 1 case spread of tomoruos infiltrate to the pelvic wall and common iliac vessels was detected intraoperatively (patient had history of radiation therapy). In 2 cases carcinomatosis of the peritoneum was found. In 1 case involvement of urinary bladder was simulated by close attachment of enlarged uterus. Conclusion: Obtained results show, that CT and MR are highly informative methods of disease spread evaluation and thus determining operability. Radiotherapy performed prior to operation sets difficulties in differentiation for tumourous infiltrate and post-radiotherapy changes in pelvis. (Full text)

Localized vortices in ηi-modes

International Nuclear Information System (INIS)

Nycander, J.; Lynov, J.P.; Juul Rasmussen, J.

1992-01-01

For a wide variety of nonlinear wave equations necessary conditions for the existence of localized, stationary structures can be found by applying a simple procedure, involving two steps: First the linear dispersion relation is obtained and the regions of the phase velocity of linear waves found. Secondly, assuming that localized solutions exist, their velocities are determined by using integral relations. The obtained velocity takes the form of a ''center of mass velocity''. If this velocity falls outside the regions of phase velocities for linear waves then nonlinear localized vortices may exist. Otherwise, the structure will couple to the linear waves and gradually disperse. Applying this method we have shown that monopole vortex solutions exist for drift waves driven by the ion temperature gradient in a magnetized plasma, the so-called η i -modes. Numerical solutions show that such vortices are steadily propagating and stable and they generally emerge from localized initial conditions. Our study is motivated by recent high resolution simulations of η i -turbulence, where it was observed that coherent vortices developed spontaneously. These had a dominating influence on the evolution of the turbulence, and the associated anomalous transport was found to be significantly reduced as compared with the predictions from quasilinear theory. (author) 8 refs., 3 figs

Go local: morality and international activism

Directory of Open Access Journals (Sweden)

Aleksandar Jokic

2013-03-01

Full Text Available A step towards constructing an ethics of international activism is proposed by formulating a series of constraints on what would constitute morally permissible agency in the context that involves delivering services abroad, directly or indirectly. Perhaps surprisingly, in this effort the author makes use of the concept of ‘force multiplier’. This idea and its official applications have explanatory importance in considering the correlation between the post-Cold War phenomenal growth in the number of international non-governmental organizations and the emergence of the US as the sole, unchallenged superpower. Four moral constraints useful for morally assessing international activism are formulated and defended. The final outcome is an argument in favor of an overarching duty for any activist-minded Westerner to go local, while developing nations are urged to closely regulate, even criminalize, activities by international activists and ‘human rights organizations’ on their territory when not in solidarity or in support of local movements. The position defended, urging the normative primacy of local over international activism, also finds support in Immanuel Kant's Third Definitive Article for A Perpetual Peace.

Semi-analytic variable charge solitary waves involving dust phase-space vortices (holes)

Energy Technology Data Exchange (ETDEWEB)

Tribeche, Mouloud; Younsi, Smain; Amour, Rabia; Aoutou, Kamel [Plasma Physics Group, Faculty of Sciences-Physics, Theoretical Physics Laboratory, University of Bab-Ezzouar, USTHB BP 32, El Alia, Algiers 16111 (Algeria)], E-mail: mtribeche@usthb.dz

2009-09-15

A semi-analytic model for highly nonlinear solitary waves involving dust phase-space vortices (holes) is outlined. The variable dust charge is expressed in terms of the Lambert function and we take advantage of this transcendental function to investigate the localized structures that may occur in a dusty plasma with variable charge trapped dust particles. Our results which complement the previously published work on this problem (Schamel et al 2001 Phys. Plasmas 8 671) should be of basic interest for experiments that involve the trapping of dust particles in ultra-low-frequency dust acoustic modes.

Semi-analytic variable charge solitary waves involving dust phase-space vortices (holes)

International Nuclear Information System (INIS)

Tribeche, Mouloud; Younsi, Smain; Amour, Rabia; Aoutou, Kamel

2009-01-01

A semi-analytic model for highly nonlinear solitary waves involving dust phase-space vortices (holes) is outlined. The variable dust charge is expressed in terms of the Lambert function and we take advantage of this transcendental function to investigate the localized structures that may occur in a dusty plasma with variable charge trapped dust particles. Our results which complement the previously published work on this problem (Schamel et al 2001 Phys. Plasmas 8 671) should be of basic interest for experiments that involve the trapping of dust particles in ultra-low-frequency dust acoustic modes.

Economics Of Rabbit Production In Abeokuta South Local ...

African Journals Online (AJOL)

This study was aimed at examining the economic profitability of rabbit production based on the hypothesis that the low level of production may likely be a consequence of low profitability of the enterprise. Abeokuta South Local Government area was used as a case study. It involved the collection of primary data from a ...

THE LEGAL INDEBTEDNESS CAPACITY OF ROMANIAN LOCAL GOVERNMENTS - THEORETICAL AND EMPIRICAL EVIDENCES

Directory of Open Access Journals (Sweden)

Bilan Irina

2011-12-01

Full Text Available The factual, not only formal capacity of local governments to appeal to borrowed resources is, considering the current conditions, a prerequisite for ensuring economic and social development of local communities. In this paper we intend to position the main theoretical and empirical evidences on local governments indebtedness capacity, mainly focusing on its sizing according to Romanian regulatory framework. With respect to previous research, the issue approached is one of great interest as it has not been, in the Romanian literature on local public finances, subject to a separate analysis of proportions. The undertaken analysis comprises a quantitative dimension, based on processed data from the consolidated general budget of Romanian local governments for 2007-2009, in permanent conjunction with monitoring and analysis of the involved qualitative aspects. To ensure the relevance of the research results, the analysis undertaken refers to the legal framework in function throughout the considered period of time, without involving the legislative changes operated in mid-2010. The main conclusions drawn from our analysis indicate that, considering the current Romanian socio-economic environment, under the impact of specific factors of different nature, the legal indebtedness capacity is far from being well valued, thus bringing its benefits to local communities development. This conclusion is valid from a global perspective as well as for different types of local communities. This appears to be inconsistent with the permanently claimed need to fund important local public investments, mainly in infrastructure, indicating, despite the high legal indebtedness capacity, the lack of factual access to borrowed resources. We suggest, therefore, to introduce the concept of effective indebtedness capacity, the result of a particularized correlation for different local governments between legal indebtedness capacity and the manifestation of several factors

Consumer Protection Towards Local Food Production In Southeast Sulawesi Indonesia

Directory of Open Access Journals (Sweden)

Suriani BT. Tolo

2015-08-01

Full Text Available Abstract Consumers have rights which should not just be ignored by businesses such as the right to be a safety the right be informed the right to be heard as well as the right to a good environment and healthy. Kendari Regency as a local government has been manifested by issuing regulations and policies that support the development of local food production such as the Mayor of Kendari regulation No. 15 of 2010 and Mayor Kendari Decree No. 427 of 2012 regarding the Establishment of Community Care Local Food. It appears that the local government is trying to make this local food as an alternative food. The type of research used in this paper is a socio-legal research reviewing the local food production from the perspective of consumer protection. The outcomes of the research indicate that responsibility of food business operators in the implementation of local production is essentially an effort to assist the government in ensuring the realization of food safety system. Therefore there is a need for awareness of the laws and regulations for all parties involved towards local food production especially in Kendari Regency Southeast Sulawesi on the food production process.

Involvement of External Stakeholders in Local Health Policymaking Process: A Case Study from Odense Municipality, Denmark

Science.gov (United States)

Karlsson, Leena Eklund; Jakobsen, Mette Winge; Winblad, Malin; Aro, Arja R.

2017-01-01

Collaboration between research and policy is an essential element for knowledge-based public health. However, only half of the Danish municipalities have experience with collaborating with researchers or other stakeholders. Through content analysis of interviews and policy documents the study explores the involvement of external stakeholders in…

Radiographic localization of unerupted mandibular anterior teeth.

Science.gov (United States)

Jacobs, S G

2000-10-01

The parallax method and the use of 2 radiographs taken at right angles to each other are the 2 methods generally used to accurately localize teeth. For the parallax method, the combination of a rotational panoramic radiograph with an occlusal radiograph is recommended. This combination involves a vertical x-ray tube shift. Three case reports are presented that illustrate: (1) how this combination can accurately localize unerupted mandibular anterior teeth, (2) how a deceptive appearance of the labiolingual position of the unerupted tooth can be produced in an occlusal radiograph, (3) how increasing the vertical angle of the tube for the occlusal radiograph makes the tube shift easier to discern, (4) why occlusal radiographs are preferable to periapical radiographs for tube shifts, and (5) how localization can also be carried out with 2 radiographs at right angles to each other, one of which is an occlusal radiograph taken with the x-ray tube directed along the long axis of the reference tooth.

Using means-end chain analysis to reveal consumers' motivation for buying local foods: An exploratory study

Directory of Open Access Journals (Sweden)

Poppy Arsil

2016-11-01

Full Text Available This article utilizes and discusses specific aspects of Means-End Chain (MEC analysis for understanding of the motives of Indonesian consumers who are involved in purchasing local foods. The MEC theory is used as a measure of attributes, consequences, and values of locally produced products involving specific aspects of this theory namely laddering methods of administration, content analysis procedure, constructing and interpreting Hierarchy Value Map (HVM. The results of the study indicate that MEC approach is a powerful method to reveal consumer motivation of local foods when associated with the various cultural groupings identified by the study particular between Javanese and Non-Javanese consumers. This study offers a practical implication and source of knowledge for other future studies and policies in term of (a a new approach for understanding the motives behind purchasing local foods for Indonesia consumers, and (b developing new categories of attributes, consequences and values of local foods.

Schwannoma of the facial nerve involving the middle cranial fossa:case report

Institute of Scientific and Technical Information of China (English)

SAI Ke; CHEN Zhong-ping

2007-01-01

@@ Facial nerve schwannoma involving the middle cranial fossa is quite rare,and its accurate diagnosis is very difficult before SUrgery.Here we present a case of schwannoma of the facial nerve at the middle cranial fossa that was misdiagnosed previously at a local hospital and then cured in our hospital.

Quantum Strategies and Local Operations

Science.gov (United States)

Gutoski, Gus

2010-02-01

This thesis is divided into two parts. In Part I we introduce a new formalism for quantum strategies, which specify the actions of one party in any multi-party interaction involving the exchange of multiple quantum messages among the parties. This formalism associates with each strategy a single positive semidefinite operator acting only upon the tensor product of the input and output message spaces for the strategy. We establish three fundamental properties of this new representation for quantum strategies and we list several applications, including a quantum version of von Neumann's celebrated 1928 Min-Max Theorem for zero-sum games and an efficient algorithm for computing the value of such a game. In Part II we establish several properties of a class of quantum operations that can be implemented locally with shared quantum entanglement or classical randomness. In particular, we establish the existence of a ball of local operations with shared randomness lying within the space spanned by the no-signaling operations and centred at the completely noisy channel. The existence of this ball is employed to prove that the weak membership problem for local operations with shared entanglement is strongly NP-hard. We also provide characterizations of local operations in terms of linear functionals that are positive and "completely" positive on a certain cone of Hermitian operators, under a natural notion of complete positivity appropriate to that cone. We end the thesis with a discussion of the properties of no-signaling quantum operations.

Local health and social care responses to implementing the national cold weather plan.

Science.gov (United States)

Heffernan, C; Jones, L; Ritchie, B; Erens, B; Chalabi, Zaid; Mays, N

2017-09-18

The Cold Weather Plan (CWP) for England was launched by the Department of Health in 2011 to prevent avoidable harm to health by cold weather by enabling individuals to prepare and respond appropriately. This study sought the views of local decision makers involved in the implementation of the CWP in the winter of 2012/13 to establish the effects of the CWP on local planning. It was part of a multi-component independent evaluation of the CWP. Ten LA areas were purposively sampled which varied in level of deprivation and urbanism. Fifty-two semi-structured interviews were held with health and social care managers involved in local planning between November 2012 and May 2013. Thematic analysis revealed that the CWP was considered a useful framework to formalize working arrangements between agencies though local leadership varied across localities. There were difficulties in engaging general practitioners, differences in defining vulnerable individuals and a lack of performance monitoring mechanisms. The CWP was welcomed by local health and social care managers, and improved proactive winter preparedness. Areas for improvement include better integration with general practice, and targeting resources at socially isolated individuals in cold homes with specific interventions aimed at reducing social isolation and building community resilience. © The Author 2017. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Rare giant cell tumor involvement of the olecranon bone

Directory of Open Access Journals (Sweden)

Chen Yang

2014-01-01

Full Text Available Giant cell tumor (GCT of bone is a relatively common benign bone lesion and is usually located in long bones, but involvement of the olecranon is extremely rare. Here, we present a case of solitary GCT of bone in the olecranon that was confirmed by preoperative needle biopsy and postoperative histological examination. The treatment included intralesional curettage, allogeneic bone grafting, and plating. At 26 months follow-up, the patient had no local recurrence.

Local perturbations perturb—exponentially–locally

International Nuclear Information System (INIS)

De Roeck, W.; Schütz, M.

2015-01-01

We elaborate on the principle that for gapped quantum spin systems with local interaction, “local perturbations [in the Hamiltonian] perturb locally [the groundstate].” This principle was established by Bachmann et al. [Commun. Math. Phys. 309, 835–871 (2012)], relying on the “spectral flow technique” or “quasi-adiabatic continuation” [M. B. Hastings, Phys. Rev. B 69, 104431 (2004)] to obtain locality estimates with sub-exponential decay in the distance to the spatial support of the perturbation. We use ideas of Hamza et al. [J. Math. Phys. 50, 095213 (2009)] to obtain similarly a transformation between gapped eigenvectors and their perturbations that is local with exponential decay. This allows to improve locality bounds on the effect of perturbations on the low lying states in certain gapped models with a unique “bulk ground state” or “topological quantum order.” We also give some estimate on the exponential decay of correlations in models with impurities where some relevant correlations decay faster than one would naively infer from the global gap of the system, as one also expects in disordered systems with a localized groundstate

Contracting communities: Conceptualizing Community Benefits Agreements to improve citizen involvement in urban development projects

NARCIS (Netherlands)

Janssen-Jansen, Leonie; Veen, van der Menno

2017-01-01

Contractual agreements are becoming increasingly important for city governments seeking to manage urban development. Contractual governance involves direct relations between the local state and different public and private actors and citizens. Although abundant literature exists on public–private

A NEW APPROACH REGARDING THE EXPENSES IN LOCAL BUDGETS FOR PUBLIC AUTHORITIES

Directory of Open Access Journals (Sweden)

CRISTINEL ICHIM

2013-02-01

Full Text Available The present study proposes a new approach regarding the expenditures for public authorities covered by localbudgets to streamline their positive impact on the improvment of the financial activitiy of local administrations. Thestudy begins with fixing the place of these expenses within the sphere of public costs from the local budget and continueswith presenting the new legislative framework of their manifestation. In the last part of the study I conceived twoalternatives to reduce the costs involved in the functioning of the local administrative system closely correlated with theterritorial and administrative reorganization of Romania.

The Local Value Chain of Hunted Red Deer Meat: A Scenario Analysis Based on a Northern Italian Case Study

Directory of Open Access Journals (Sweden)

Anna Gaviglio

2018-05-01

Full Text Available Although in recent decades, meat from hunted wild ungulates has shown interesting results in terms of market opportunities, the scientific literature is still lacking in economic studies concerning the estimation of the meat’s value for involved stakeholders. We present an analysis of the evolution of price in the local red deer meat supply chain. This analysis has been conducted through a survey based on in-depth interviews with the stakeholders involved in an Italian local supply chain. Findings derived from this study describe a case study, however, they also represent the potential dynamics of the value of Italian game meat, highlighting that the development of a sustainable local supply chain of this product may represent an economic resource for involved stakeholders.

Evolution of local citizen participation schemes in the German wind market

International Nuclear Information System (INIS)

Enzenberger, N.; Fichtner, W.; Rentz, O.

2003-01-01

Local citizen participation schemes like the German 'Buergerwindparks' (citizen wind farm) have been an important vehicle to develop the wind energy business to its present state of market maturity. This article discusses ownership as an integrated part of the economic project design for renewable energy projects. Different forms of local citizen participation are differentiated and strategic aspects related to the entrepreneurial decision of involving local citizens are highlighted. Then, the focus will be on a description of different role models for local citizen-financed wind energy projects. The paper also explains the evolution of two new role models: the merger of existing project companies to larger citizen-owned project portfolio companies and the role of closed-end wind funds as a new equity provision approach. Finally, the role of local citizen participation schemes in different market phases is discussed. (author)

LOCAL COMMUNITY INVOLVEMENT IN TOURISM DEVEOPMENT

Directory of Open Access Journals (Sweden)

Maria TĂTĂRUȘANU

2016-12-01

Full Text Available The issue of community participation in tourism development has been brought in front of the sector decision makers and researchers mostly during the last period of time. It could be a source of benefits and it could also create a better relationship between the tourism companies and the community groups. In this paper the author writes a literature review on this subject in order to draw attention on this issue in the Romanian tourism literature and to create an analysis framework for specific cases of tourism development plans.

Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

International Nuclear Information System (INIS)

Straka, Elisabeth; Ellinger, Isabella; Balthasar, Christina; Scheinast, Matthias; Schatz, Jasmin; Szattler, Tamara; Bleichert, Sonja; Saleh, Leila; Knöfler, Martin; Zeisler, Harald; Hengstschläger, Markus; Rosner, Margit; Salzer, Hans; Gundacker, Claudia

2016-01-01

Highlights: • It is known that MeHg is able to pass the placenta and to affect fetal brain development. • Uptake and efflux transporters were examined in human primary trophoblast cells and BeWo cells. • Involvement in mercury transfer was assessed by measurement of cellular mercury content upon siRNA mediated gene knockdown. • Localization of transporters was determined by immunofluorescence microscopy. • LAT1 and rBAT at the apical membrane of the syncytiotrophoblast (STB) are involved in MeHg uptake. • MRP1 located at basal membrane of STB mediates mercury efflux. - Abstract: Background: The capacity of the human placenta to handle exogenous stressors is poorly understood. The heavy metal mercury is well-known to pass the placenta and to affect brain development. An active transport across the placenta has been assumed. The underlying mechanisms however are virtually unknown. Objectives: Uptake and efflux transporters (17 candidate proteins) assumed to play a key role in placental mercury transfer were examined for expression, localization and function in human primary trophoblast cells and the trophoblast-derived choriocarcinoma cell line BeWo. Methods: To prove involvement of the transporters, we used small interfering RNA (siRNA) and exposed cells to methylmercury (MeHg). Total mercury contents of cells were analyzed by Cold vapor-atomic fluorescence spectrometry (CV-AFS). Localization of the proteins in human term placenta sections was determined via immunofluorescence microscopy. Results: We found the amino acid transporter subunits L-type amino acid transporter (LAT)1 and rBAT (related to b 0,+ type amino acid transporter) as well as the efflux transporter multidrug resistance associated protein (MRP)1 to be involved in mercury kinetics of trophoblast cells (t-test P < 0.05). Conclusion: The amino acid transporters located at the apical side of the syncytiotrophoblast (STB) manage uptake of MeHg. Mercury conjugated to glutathione (GSH) is

Thermal and pressure pain sensitivity in patients with unilateral shoulder pain: comparison of involved and uninvolved sides.

Science.gov (United States)

Coronado, Rogelio A; Kindler, Lindsay L; Valencia, Carolina; George, Steven Z

2011-03-01

Cross-sectional. In the examination of patients with unilateral shoulder pain, pain provocation testing to compare the involved and uninvolved sides has been considered useful. However, side-to-side comparisons of experimental pain sensitivity in patients with unilateral shoulder pain are not widely reported in the literature. To compare experimental pain sensitivity between the involved and uninvolved sides in patients with unilateral shoulder pain. In consecutive patients seeking operative treatment for shoulder pain, sensitivity measures of bilateral pressure pain threshold at the shoulder and forearm, and thermal pain threshold, tolerance, and temporal summation at the forearm, were examined. Pressure sensitivity was tested with a Fischer pressure algometer, and thermal sensitivity with a computer-controlled Medoc neurosensory analyzer. The involved and uninvolved sides were compared with an analysis of variance. Influence of sex and location of testing were considered as covariates in the analysis. Fifty-nine consecutively recruited participants completed experimental pain sensitivity testing. Participants reported significantly lower pressure pain thresholds in the involved side compared to the uninvolved side (F1,56 = 4.96, P = .030). In addition, female compared to male participants demonstrated lower pressure pain thresholds in the bilateral shoulder regions (F1,56 = 10.84, P = .002). There was no difference in thermal pain sensitivity between sides. Average clinical pain intensity was negatively correlated with pressure pain threshold at the involved local site (r = -0.284, P = .029), indicating an influence of clinical pain intensity on local pressure pain. The results of this study provide evidence for higher experimental pressure pain sensitivity in the involved side of patients with unilateral shoulder pain and no difference between sides for thermal pain sensitivity. Females demonstrated higher pain sensitivity than males to pressure stimuli at the

Nuclear import of influenza B virus nucleoprotein: Involvement of an N-terminal nuclear localization signal and a cleavage-protection motif

International Nuclear Information System (INIS)

Wanitchang, Asawin; Narkpuk, Jaraspim; Jongkaewwattana, Anan

2013-01-01

The nucleoprotein of influenza B virus (BNP) shares several characteristics with its influenza A virus counterpart (ANP), including localization in the host's nucleus. However, while the nuclear localization signal(s) (NLS) of ANP are well characterized, little is known about those of BNP. In this study, we showed that the fusion protein bearing the BNP N-terminus fused with GFP (N70–GFP) is exclusively nuclear, and identified a highly conserved KRXR motif spanning residues 44–47 as a putative NLS. In addition, we demonstrated that residues 3–15 of BNP, though not an NLS, are also crucial for nuclear import. Results from mutational analyses of N70–GFP and the full-length BNP suggest that this region may be required for protection of the N-terminus from proteolytic cleavage. Altogether, we propose that the N-terminal region of BNP contains the NLS and cleavage-protection motif, which together drive its nuclear localization. - Highlights: • The N-terminal region of BNP is required for nuclear accumulation. • The conserved motif at position 44–47 is a putative nuclear localization signal. • The first 15 amino acids of BNP may function as a cleavage-protection motif. • BNP may get access to the nucleus via a mechanism distinct from ANP

Alfalfa Mob1-like proteins are involved in cell proliferation and are localized in the cell division plane during cytokinesis

International Nuclear Information System (INIS)

Citterio, Sandra; Piatti, Simonetta; Albertini, Emidio; Aina, Roberta; Varotto, Serena; Barcaccia, Gianni

2006-01-01

Mps-one-binder (Mob) proteins play a crucial role in yeast cytokinesis. After cloning two Mob1-like genes, MsMob1-A and MsMob1-B from alfalfa (Medicago sativa L.) we show that, although they are constitutively expressed in roots, stems, leaves, flowers and pods, their transcripts and proteins are mostly produced in actively proliferating tissues. A polyclonal antibody specifically raised against MsMob1 proteins was used for immunolocalization studies in synchronized root tip cells. The subcellular localization of MsMob1-like proteins is demonstrated to be cell cycle-regulated. Cytoplasmic localization is faint and diffused during G 1 and S. It becomes concentrated in punctuate and fibrillar structures in G 2 as well as M phase. At the stage of cytokinesis, the protein is found at the emerging cell plate marking the progressive formation of the septum. Mob1 proteins partially co-localize with microtubules structures functionally related to the spindles and important for cytokinesis in eukaryotic cells. The MsMob1 expression cannot rescue the lethality of the yeast mob1 mutant, suggesting that interaction of Mob1 proteins with their effectors may be species-specific. Localization of Mob1 proteins in the inner layer of the root cap indicates an additional function for this class of proteins in plants, which is likely related to the onset of programmed cell death

Nuclear import of influenza B virus nucleoprotein: Involvement of an N-terminal nuclear localization signal and a cleavage-protection motif

Energy Technology Data Exchange (ETDEWEB)

Wanitchang, Asawin; Narkpuk, Jaraspim; Jongkaewwattana, Anan, E-mail: anan.jon@biotec.or.th

2013-08-15

The nucleoprotein of influenza B virus (BNP) shares several characteristics with its influenza A virus counterpart (ANP), including localization in the host's nucleus. However, while the nuclear localization signal(s) (NLS) of ANP are well characterized, little is known about those of BNP. In this study, we showed that the fusion protein bearing the BNP N-terminus fused with GFP (N70–GFP) is exclusively nuclear, and identified a highly conserved KRXR motif spanning residues 44–47 as a putative NLS. In addition, we demonstrated that residues 3–15 of BNP, though not an NLS, are also crucial for nuclear import. Results from mutational analyses of N70–GFP and the full-length BNP suggest that this region may be required for protection of the N-terminus from proteolytic cleavage. Altogether, we propose that the N-terminal region of BNP contains the NLS and cleavage-protection motif, which together drive its nuclear localization. - Highlights: • The N-terminal region of BNP is required for nuclear accumulation. • The conserved motif at position 44–47 is a putative nuclear localization signal. • The first 15 amino acids of BNP may function as a cleavage-protection motif. • BNP may get access to the nucleus via a mechanism distinct from ANP.

Technology Transfer, Labour and Local Learning Processes in Malaysian Industry

DEFF Research Database (Denmark)

Wangel, Arne

1999-01-01

The transfer of technologies by the foreign electronic industries operating in Malaysia involves training of workers for various purposes. The upgrading of skills to assimilate the transferred technology aims at increasing productivity and product quality. Communicating awareness about work hazards...... is meant to reduce breakdowns in production and workers' accidents. How do the training paradigms, which transnationals introduce in their subsidiaries in Malaysia, interact with the preconditions of learning with the local labour force? In shaping local learning processes, what is the scope for workers...

Sound localization and occupational noise

Directory of Open Access Journals (Sweden)

Pedro de Lemos Menezes

2014-02-01

Full Text Available OBJECTIVE: The aim of this study was to determine the effects of occupational noise on sound localization in different spatial planes and frequencies among normal hearing firefighters. METHOD: A total of 29 adults with pure-tone hearing thresholds below 25 dB took part in the study. The participants were divided into a group of 19 firefighters exposed to occupational noise and a control group of 10 adults who were not exposed to such noise. All subjects were assigned a sound localization task involving 117 stimuli from 13 sound sources that were spatially distributed in horizontal, vertical, midsagittal and transverse planes. The three stimuli, which were square waves with fundamental frequencies of 500, 2,000 and 4,000 Hz, were presented at a sound level of 70 dB and were randomly repeated three times from each sound source. The angle between the speaker's axis in the same plane was 45°, and the distance to the subject was 1 m. RESULT: The results demonstrate that the sound localization ability of the firefighters was significantly lower (p<0.01 than that of the control group. CONCLUSION: Exposure to occupational noise, even when not resulting in hearing loss, may lead to a diminished ability to locate a sound source.

screening and improvement of local isolates of aspergillus niger

African Journals Online (AJOL)

DR. AMINU

ABSTRACT. The study involved the screening of fourteen isolates of Aspergillus niger for citric acid production from glucose. The study was aimed at screening and improving local strains of Aspergillus niger with potential for citric acid production. All the isolates screened produced varying amounts of citric acid, the highest ...

Localized scleroderma: imaging features

Energy Technology Data Exchange (ETDEWEB)

Liu, P. (Dept. of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON (Canada)); Uziel, Y. (Div. of Rheumatology, Hospital for Sick Children, Toronto, ON (Canada)); Chuang, S. (Dept. of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON (Canada)); Silverman, E. (Div. of Rheumatology, Hospital for Sick Children, Toronto, ON (Canada)); Krafchik, B. (Div. of Dermatology, Dept. of Pediatrics, Hospital for Sick Children, Toronto, ON (Canada)); Laxer, R. (Div. of Rheumatology, Hospital for Sick Children, Toronto, ON (Canada))

1994-06-01

Localized scleroderma is distinct from the diffuse form of scleroderma and does not show Raynaud's phenomenon and visceral involvement. The imaging features in 23 patients ranging from 2 to 17 years of age (mean 11.1 years) were reviewed. Leg length discrepancy and muscle atrophy were the most common findings (five patients), with two patients also showing modelling deformity of the fibula. One patient with lower extremity involvement showed abnormal bone marrow signals on MR. Disabling joint contracture requiring orthopedic intervention was noted in one patient. In two patients with ''en coup de sabre'' facial deformity, CT and MR scans revealed intracranial calcifications and white matter abnormality in the ipsilateral frontal lobes, with one also showing migrational abnormality. In a third patient, CT revealed white matter abnormality in the ipsilateral parietal lobe. In one patient with progressive facial hemiatrophy, CT and MR scans showed the underlying hypoplastic left maxillary antrum and cheek. Imaging studies of areas of clinical concern revealed positive findings in half our patients. (orig.)

Public involvement in decision making process in nuclear field

International Nuclear Information System (INIS)

Constantin, M.; Diaconu, D.

2009-01-01

Decision Making Process (DMP) in nuclear field is influenced by multiple factors such as: complex technical aspects, diversity of stakeholders, long term risks, psychological stresses, societal attitudes, etc. General public is sometimes considered as the only one of stakeholders, the involvement of the public being seen as a factor to obtain the acceptance in the late phase of DMP. Generally it is assessed by public consultation on the environment impact studies and by approval of the sitting through the local authorities decision. Modern society uses methods to involve public from the beginning of DMP. The paper shows a general view of the methods and tools used in Europe for public involvement in DMP. The process of construction of a continuous democratic dialog inside of Romanian Stakeholder Group (RSG) in the frame of the FP6-COWAM2 and CIP projects is presented with a focusing of the barriers and factors of disturbing the trust and collaboration between stakeholders. The influence on the public acceptance is also discussed. (authors)

Stakeholders and public involvement for flood protection: traditional river management organisations for a better consideration of local knowledge?

Science.gov (United States)

Utz, Stephan; Lane, Stuart; Reynard, Emmanuel

2016-04-01

This research explores participatory processes in the domain of river management in Switzerland. The main objective is to understand how traditional, highly participatory, local organisations for flood protection have been institutionalised into current river management policy, and to what extent this has impacted on wider participatory processes of producing knowledge. Traditionally, flood protection strategies have been based upon scientific knowledge but have often ignored the capacities of local actors to contribute to the development of the policy. Thus, there may be a gap between scientists, stakeholders and the public that favours controversies and leads to opposition to flood protection projects. In order to reduce this gap and to increase incorporation of local knowledge, participatory processes are set up. They are considered as allowing the integration of all the actors concerned by flood risks to discuss their positions and to develop alternative solutions. This is a particularly important goal in the Swiss political system where direct democracy (the possibility of calling the decision of any level of government into question through a popular vote) means that a reasonable level of project acceptance is a necessary element of project. In order to support implementation of participatory processes, federal funding includes a special grant to cover the additional costs due to these actions. It is considered that, since its introduction in 2008, this grant certainly furthered participatory processes for flood protection projects and fostered water management policy implementation. However, the implication of stakeholders and public in decision-making processes is much well-established than modern river management often assumes. In some regions, flood protection tasks have been traditionally assumed by local organisations such as dyke corporations (DCs). These comprise land and property owners who are DC members and have to participate in flood protection

Convection with local thermal non-equilibrium and microfluidic effects

CERN Document Server

Straughan, Brian

2015-01-01

This book is one of the first devoted to an account of theories of thermal convection which involve local thermal non-equilibrium effects, including a concentration on microfluidic effects. The text introduces convection with local thermal non-equilibrium effects in extraordinary detail, making it easy for readers newer to the subject area to understand. This book is unique in the fact that it addresses a large number of convection theories and provides many new results which are not available elsewhere. This book will be useful to researchers from engineering, fluid mechanics, and applied mathematics, particularly those interested in microfluidics and porous media.

The use of local substrates in the production of legume nodulating ...

African Journals Online (AJOL)

SARAH

2014-03-31

Mar 31, 2014 ... The production of LNB inoculants is easy, using organic local matter as carriers of inoculants. ... involving microbial fertilizers are recommended for sub-Saharan ... market. Fish meal is localy use for the nutrition of animals.

Local Sustainability and Cooperation Actions in the Mediterranean Region

Directory of Open Access Journals (Sweden)

Tiberio Daddi

2014-05-01

Full Text Available The populations of the Middle East and Africa are increasing rapidly, contributing to rapid urban growth. This paper describes a two-year action research process involving diverse public, private, and community stakeholders. The actions aimed to develop and strengthen the capabilities of three Mediterranean cities (Marrakech, Morocco; Sin el Fil, Lebanon; and Bodrum, Turkey in managing and promoting local sustainable development. The needs and priorities of each Mediterranean partner were identified and pilot actions were elaborated to promote urban sustainability, the exploitation of local resources, and the enhancement of local tangible and intangible assets. The paper describes the outputs of pilot actions carried out in these cities, highlighting how these experiences contribute to the current debate on urban sustainability. Broad implications for policy and practice are discussed.

Germinoma with Involvement of Midline and Off-Midline Intracranial Structures

Directory of Open Access Journals (Sweden)

Monica Graciela Loto

2014-01-01

Full Text Available Germinomas are malignant intracranial germ tumors, usually found in suprasellar regions. Less than 10% are localized in off-middle structures, and synchronous involvement of both structures has only exceptionally been published. A case of an 18-year-old male patient with progressive right-sided hemiparesis and panhypopituitarism was reviewed. Brain MRI showed a solid mass involving pituitary and hypothalamus with thickening of pituitary stalk, high intensity lesions on T2-weighted imaging in left internal capsule, caudate nucleus, globus pallidus, and mild atrophy of the left internal capsule and cerebral peduncle. Nonadenomatous lesions were considered in the differential diagnosis. Alfa-fetoprotein (AFP levels were negative in both serum and cerebrospinal fluid (CSF, while β-human chorionic gonadotrophin (β-HCG levels were slightly increased in CSF. A transsphenoidal biopsy identified a germinoma. Four cycles of chemotherapy with bleomicine, etoposide, and cysplatin were given, followed by radiotherapy, but patients died due to a recidiva. Conclusion. Germinoma must be considered in patients with insipidus diabetes with a sellar mass with thickening of pituitary stalk; and ectopic germinoma must be suspected in patients with slowly progressive hemiparesis with cerebral hemiatrophy. Even with a rare condition, colocalization of midline and off-midline germinoma must be suspected in the presence of these typical signs of both localizations.

Local Foods, Local Places Summary Reports

Science.gov (United States)

These reports summarize community projects done with Local Foods, Local Places assistance, including farmers markets, cooperatives, community gardens, and other food-related enterprises that can boost local economies and drive revitalization.

Complex treatment of localized bone marrow sarcoma in children

International Nuclear Information System (INIS)

Kolygin, B.A.; Punanov, Yu.A.; Malinin, A.P.; Safonova, S.A.

1997-01-01

The retrospective analysis included the results of the treatment of 67 children suffering from localized sarcomas of bone (Ewing's sarcoma, lymphosarcoma). The advantage was demonstrated in patients, received combination of chemotherapy and radiotherapy on the involved bone. The resection of the primary tumor in combination with radio-chemotherapy improves the 10-year survival

Overall view of the preparation of the environmental protection programme or Local Agenda 21

Directory of Open Access Journals (Sweden)

Emil Šterbenk

2002-12-01

Full Text Available An Environmental Protection Programme and a Local Agenda 21 are documents intended for promotion of sustainable development in the local co-mmunities. Both documents should be realistic and capable of implementation. The local community, the public and all the main companies and organisations should be involved in the preparation and the realisation of the programmes. In this contribution the contents of the programmes and some experiences and advice tothose taking part are discussed.

Identification of signals that facilitate isoform specific nucleolar localization of myosin IC

Energy Technology Data Exchange (ETDEWEB)

Schwab, Ryan S.; Ihnatovych, Ivanna; Yunus, Sharifah Z.S.A.; Domaradzki, Tera [Department of Physiology and Biophysics, University at Buffalo—State University of New York, Buffalo, NY (United States); Hofmann, Wilma A., E-mail: whofmann@buffalo.edu [Department of Physiology and Biophysics, University at Buffalo—State University of New York, Buffalo, NY (United States)

2013-05-01

Myosin IC is a single headed member of the myosin superfamily that localizes to the cytoplasm and the nucleus, where it is involved in transcription by RNA polymerases I and II, intranuclear transport, and nuclear export. In mammalian cells, three isoforms of myosin IC are expressed that differ only in the addition of short isoform-specific N-terminal peptides. Despite the high sequence homology, the isoforms show differences in cellular distribution, in localization to nuclear substructures, and in their interaction with nuclear proteins through yet unknown mechanisms. In this study, we used EGFP-fusion constructs that express truncated or mutated versions of myosin IC isoforms to detect regions that are involved in isoform-specific localization. We identified two nucleolar localization signals (NoLS). One NoLS is located in the myosin IC isoform B specific N-terminal peptide, the second NoLS is located upstream of the neck region within the head domain. We demonstrate that both NoLS are functional and necessary for nucleolar localization of specifically myosin IC isoform B. Our data provide a first mechanistic explanation for the observed functional differences between the myosin IC isoforms and are an important step toward our understanding of the underlying mechanisms that regulate the various and distinct functions of myosin IC isoforms. - Highlights: ► Two NoLS have been identified in the myosin IC isoform B sequence. ► Both NoLS are necessary for myosin IC isoform B specific nucleolar localization. ► First mechanistic explanation of functional differences between the isoforms.

Localization of Point Sources for Poisson Equation using State Observers

KAUST Repository

Majeed, Muhammad Usman

2016-08-09

A method based On iterative observer design is presented to solve point source localization problem for Poisson equation with riven boundary data. The procedure involves solution of multiple boundary estimation sub problems using the available Dirichlet and Neumann data from different parts of the boundary. A weighted sum of these solution profiles of sub-problems localizes point sources inside the domain. Method to compute these weights is also provided. Numerical results are presented using finite differences in a rectangular domain. (C) 2016, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Localization of Point Sources for Poisson Equation using State Observers

KAUST Repository

Majeed, Muhammad Usman; Laleg-Kirati, Taous-Meriem

2016-01-01

A method based On iterative observer design is presented to solve point source localization problem for Poisson equation with riven boundary data. The procedure involves solution of multiple boundary estimation sub problems using the available Dirichlet and Neumann data from different parts of the boundary. A weighted sum of these solution profiles of sub-problems localizes point sources inside the domain. Method to compute these weights is also provided. Numerical results are presented using finite differences in a rectangular domain. (C) 2016, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Localized strain measurements of the intervertebral disc annulus during biaxial tensile testing.

Science.gov (United States)

Karakolis, Thomas; Callaghan, Jack P

2015-01-01

Both inter-lamellar and intra-lamellar failures of the annulus have been described as potential modes of disc herniation. Attempts to characterize initial lamellar failure of the annulus have involved tensile testing of small tissue samples. The purpose of this study was to evaluate a method of measuring local surface strains through image analysis of a tensile test conducted on an isolated sample of annular tissue in order to enhance future studies of intervertebral disc failure. An annulus tissue sample was biaxial strained to 10%. High-resolution images captured the tissue surface throughout testing. Three test conditions were evaluated: submerged, non-submerged and marker. Surface strains were calculated for the two non-marker conditions based on motion of virtual tracking points. Tracking algorithm parameters (grid resolution and template size) were varied to determine the effect on estimated strains. Accuracy of point tracking was assessed through a comparison of the non-marker conditions to a condition involving markers placed on tissue surface. Grid resolution had a larger effect on local strain than template size. Average local strain error ranged from 3% to 9.25% and 0.1% to 2.0%, for the non-submerged and submerged conditions, respectively. Local strain estimation has a relatively high potential for error. Submerging the tissue provided superior strain estimates.

IDENTIFYING MOTIVATION FACTOR INVOLVEMENT OF SARAWAK MALAY WOMEN ENTREPRENEUR

Directory of Open Access Journals (Sweden)

Masyantie Mohamad

2016-03-01

Full Text Available Sarawak multilayered cake among Sarawak product signature famous among the local as well as international tourist visiting Sarawak. In fact, Sarawak Malay women entrepreneurs have become very necessary players in the entrepreneurial field specifically in this cottage industries from the early introduction of this business, they have facing various problem in this businesses. Thus, this research aims to build an understanding of motivational factor that encourage Sarawak Malay women entrepreneurial experiences especially in multilayered cake businesses. Using qualitative methods, this research aims to identify the entrepreneurial motivations factors; with regards to start-up motivation by Sarawak Malay women. The finding shows that the motivations that influence Malay women within Kuching, Sarawak areas to start and grow their business are involve self-driven and context driven that motivate them involve in multilayered cakes businesses.

Predicting the local outcome of glottic squamous cell carcinoma after definitive radiation therapy: value of computed tomography-determined tumour parameters

International Nuclear Information System (INIS)

Hermans, R.; Van den Bogaert, W.; Rijnders, A.; Doornaert, P.; Baert, A.L.

1999-01-01

Background and purpose: The T-classification has shortcomings in the prediction of local outcome of glottic squamous cell carcinoma (SCC) treated by definitive radiation therapy. In this regard, the value of several CT-derived tumour parameters as predictors of local outcome was investigated. Materials and methods: The pretreatment CT studies of 119 patients with glottic SCC (T1, n=61; T2, n=40; T3, n=14; T4, n=4) treated with curative intent by radiation therapy were reviewed for tumoral involvement of specific laryngeal anatomic subsites (including laryngeal cartilages). Tumour volume was calculated with the summation-of-areas technique. Actuarial (life-table) statistical analysis was done for each of the covariates; multivariate analysis was performed using the Cox proportional hazards model.Results: In the actuarial analysis tumour volume was significantly correlated with local recurrence rate (P=0.0062). Involvement of the cricoid cartilage (P=0.0052), anterior commissure (P=0.0203), subglottis (P=0.0481) and preepiglottic space (P=0.0134) and degree of involvement of the true vocal cord (P=0.0441) and paraglottic space at the level of the true vocal cord (P=0.0002) were also significantly correlated with local recurrence rate. In the multivariate analysis, only degree of involvement of the paraglottic space (at the level of the true vocal cord) (P=0.0001) and preepiglottic space (P=0.02) were found to be independent predictors of local recurrence. The T-category was significantly correlated with local outcome in the actuarial analysis (P=0.0001), but not in the multivariate analysis (P=0.5915). Conclusions: Several CT-derived parameters are powerful predictors of local outcome in glottic cancer treated with radiation therapy; some of these parameters are stronger linked to the local control rate than the T-classification. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

When can a green entrepreneur manage the local environment?

Science.gov (United States)

Brandt, Urs Steiner; Svendsen, Gert Tinggaard

2016-12-01

How do we deal with environmental management issues at the local level? Traditionally, the approach proposed from an environmental management perspective has involved various kinds of "top-down" regulatory measures, such as defining a standard that must be satisfied or a tax on pollution. Conversely, there has been less focus on the analysis of local, bottom-up approaches, as for example the effectiveness of various ways of organizing a local environmental transition process. Our focus is on analyzing of under what conditions it is possible for a "green entrepreneur" (GE) to manage a transition from brown to green energy? Theoretically, we consider four entrepreneurial skills, at least two of which must be present for the GE to succeed. In the case of the Danish island of Samsø and its rapid introduction of renewable energy, three of these skills are found to be present: profits, communication, and trustworthiness. The GE, however, failed to activate the fourth skill concerning the ability to persuade local non-green actors regarding the value of the green component. Thus, a main result is that it is crucial to convince non-green locals about the profitability of local environmental management rather than its potentially green components. Copyright © 2016 Elsevier Ltd. All rights reserved.

Local and Transnational Care Relations

DEFF Research Database (Denmark)

Dalgas, Karina Märcher; Olwig, Karen Fog

2015-01-01

An increasing number of young women from the Global South have become au pairs in the Global North since the turn of the millennium. Through ethnographic analysis of three cases of au pairing in Denmark, involving Filipina and Caribbean women, this article discusses the nature of the local as well...... as transnational family relations in which these women are embedded as au pairs, and the opportunities and restraints that they present. We use anthropological theory to conceptualize family and kinship in terms of notions and practices of relatedness. This offers a useful framework for elucidating the different...

Global trends on local grounds

DEFF Research Database (Denmark)

Steensen, Jette Johanne

2006-01-01

Collection of papers produced by tutors involved in a master´s degree course for teacher in Ethiopia offers an important challenge to the dominant neo-liberal agenda that has taken over educational reform throughtout the world. The project was based on the practice of critical practitioner inquiry...... and built upon similar efforts in Namibia in the 1990s. Steensen´s contribution stresses that any educational system will have to lie firmly on local grounds, that international trends must be analysed strategically as well as critically and that such analysis, for example through Critical Practitioner...

Local Government and Traditional Authorities in Concert: Towards a More Productive Relationship

Directory of Open Access Journals (Sweden)

Callistus Mahama

2009-11-01

Full Text Available Ghana embarked on decentralisation in 1988 as a way of bringing decision making closer to the people. Since then, there have several reforms with a view to strengthening local governance. This article identifies a major challenge still facing Ghana’s decentralisation: Partnership between local government and traditional authorities. The paper discusses the fuzzy relationship between local governments and traditional authorities as a result of constitutional and legislative ambiguity on their relationship. Traditional Authorities perform important functions in the country, albeit their roles have waned since independence. Yet current legal provisions on local government have not sufficiently clarified their role in local administration. This has led to a murky and competing relationship between traditional authorities and local governments. In localities where mutual relationship exists, it is mainly as a result of the personalities involved and this has had a positive effect on the development of the area. The paper concludes by advocating for measures which among others include a re-enactment of legislation which will define the working relationship between traditional authorities and local government.

New design competences for localized production systems

DEFF Research Database (Denmark)

Eriksen, Kaare Riise; Morelli, Nicola

2005-01-01

This paper discusses the current development in production culture, based on local production networks. The role of the designer is put in perspective and outlined through a research project, Den Grønne Møbel (DGM), where different design areas were coordinated in a business concept...... in fully industrialized countries such as Denmark and represents an interesting alternative to globalized industrial production. Furthermore this case is an interesting opportunity to re-discuss the role and competences of designers in such new models. Tools and methods of the design profession...... and an organization involving different stakeholders. For several years now, DGM has been producing furniture from local materials, hereby aiming to create a new culture for well designed and environmentally sound furniture with a ‘story’. Although not totally new, this organizational model is particularly innovative...

Local randomization in neighbor selection improves PRM roadmap quality

KAUST Repository

McMahon, Troy; Jacobs, Sam; Boyd, Bryan; Tapia, Lydia; Amato, Nancy M.

2012-01-01

Probabilistic Roadmap Methods (PRMs) are one of the most used classes of motion planning methods. These sampling-based methods generate robot configurations (nodes) and then connect them to form a graph (roadmap) containing representative feasible pathways. A key step in PRM roadmap construction involves identifying a set of candidate neighbors for each node. Traditionally, these candidates are chosen to be the k-closest nodes based on a given distance metric. In this paper, we propose a new neighbor selection policy called LocalRand(k,K'), that first computes the K' closest nodes to a specified node and then selects k of those nodes at random. Intuitively, LocalRand attempts to benefit from random sampling while maintaining the higher levels of local planner success inherent to selecting more local neighbors. We provide a methodology for selecting the parameters k and K'. We perform an experimental comparison which shows that for both rigid and articulated robots, LocalRand results in roadmaps that are better connected than the traditional k-closest policy or a purely random neighbor selection policy. The cost required to achieve these results is shown to be comparable to k-closest. © 2012 IEEE.

Local randomization in neighbor selection improves PRM roadmap quality

KAUST Repository

McMahon, Troy

2012-10-01

Probabilistic Roadmap Methods (PRMs) are one of the most used classes of motion planning methods. These sampling-based methods generate robot configurations (nodes) and then connect them to form a graph (roadmap) containing representative feasible pathways. A key step in PRM roadmap construction involves identifying a set of candidate neighbors for each node. Traditionally, these candidates are chosen to be the k-closest nodes based on a given distance metric. In this paper, we propose a new neighbor selection policy called LocalRand(k,K\\'), that first computes the K\\' closest nodes to a specified node and then selects k of those nodes at random. Intuitively, LocalRand attempts to benefit from random sampling while maintaining the higher levels of local planner success inherent to selecting more local neighbors. We provide a methodology for selecting the parameters k and K\\'. We perform an experimental comparison which shows that for both rigid and articulated robots, LocalRand results in roadmaps that are better connected than the traditional k-closest policy or a purely random neighbor selection policy. The cost required to achieve these results is shown to be comparable to k-closest. © 2012 IEEE.

Electoral Proximity and the Political Involvement of Bureaucrats: A Natural Experiment in Argentina, 1904

Directory of Open Access Journals (Sweden)

Valentín Figueroa

2016-01-01

Full Text Available In this paper, I use a slightly modified version of the Becker–Stigler model of corrupt behavior to explain bureaucratic political involvement. Since bureaucrats prefer higher rewards and not to support losing candidates, we expect them to become politically involved near elections – when rewards are expected to be higher, and information more abundant. Taking advantage of a natural experiment, I employ differences-in-means and differences-in-differences techniques to esti-mate the effect of electoral proximity on the political involvement of justices of the peace in the city of Buenos Aires in 1904. I find a large, positive, and highly local effect of electoral proximity on their political involvement, with no appreciable impact in the months before or after elections.

Is epidermal growth factor involved in development of duodenal polyps in familial polyposis coli?

DEFF Research Database (Denmark)

Poulsen, Steen Seier

1988-01-01

Duodenal adenomas are a frequent extracolonic manifestation in patients with familial polyposis coli (FPC). Epidermal growth factor (EGF), a polypeptide that stimulates cellular growth and differentiation, is localized in Paneth cells in the small intestine. In two patients with FPC, we found EGF...... immunoreactivity in duodenal adenomas. Numerous EGF immunoreactive Paneth cells were localized, not as usually, in the bottom of the crypts, but scattered along the crypts alone or in clusters. We do not know whether EGF is involved in the development of duodenal polyps in FPC patients, or whether the present...

Localization of lesions in aphasia, (2). Clinical-CT scan correlations

Energy Technology Data Exchange (ETDEWEB)

Hojo, Kei; Watanabe, Shunzo; Tasaki, Hiroichi; Sato, Tokijiro (Hirosaki Univ., Aomori (Japan). School of Medicine); Metoki, Hirofumi

1985-01-01

The relationship between the focus and the extent of the lesions and the various symptoms was investigated. 1. Broca aphasics: More than 80% of the group with obvious anarthric components had lesions of the third frontal gyrus involving Broca's area and the lower part of the precental gyrus as well as opercular and insular regions. The size of the lesions of this group was significantly larger than that of the group without marked anarthric components, and the latter was proved to have little localizing value. 2. Wernicke aphasics: The group with poor reading comprehension had cortical and/or subcortical lesions, involving posterior parts of both superior and middle temporal gyri as well as the supramarginal gyrus. On the other hand, lesions of the group with poor auditory comprehension were more anteriorly located and localized in the deep structures. Lesions of the group with poor Token test scores were large and scattered more anteriorly and/or posteriorly compared with those of the group with good Token test scores. 3. Amnestic aphasics: The group with poor naming scores had somewhat larger lesions than the group with good naming scores, and the lesions were scattered about the left hemisphere. The finding has proved that both groups had little localizing value. 4. Conduction aphasics: Lesions of the non-fluent type were significantly larger than those of the fluent type and distributed more anteriorly. However, highly involved lesions were located in the supramarginal gyrus and posterior parts of superior and/or middle temporal gyri. 5. Global aphasics: Lesions of the group with good articulation and prosody were observed to distribute more posteriorly in comparison with those of the other global aphasics.

The involvement of glucose-6-phosphatase in mucilage secretion by root cap cells of Zea mays

Science.gov (United States)

Moore, R.; McClelen, C. E.

1985-01-01

In order to determine the involvement of glucose-6-phosphatase in mucilage secretion by root cap cells, we have cytochemically localized the enzyme in columella and peripheral cells of root caps of Zea mays. Glucose-6-phosphatase is associated with the plasmalemma and cell wall of columella cells. As columella cells differentiate into peripheral cells and begin to produce and secrete mucilage, glucose-6-phosphatase staining intensifies and becomes associated with the mucilage and, to a lesser extent, the cell wall. Cells being sloughed from the cap are characterized by glucose-6-phosphatase staining being associated with the vacuole and plasmalemma. These changes in enzyme localization during cellular differentiation in root caps suggest that glucose-6-phosphatase is involved in the production and/or secretion of mucilage by peripheral cells of Z. mays.

Local self governance in health - a study of it's functioning in Odisha, India.

Science.gov (United States)

Panda, Bhuputra; Zodpey, Sanjay P; Thakur, Harshad P

2016-10-31

Local decision making is linked to several service quality improvement parameters. Rogi Kalyan Samitis (RKS) at peripheral decision making health units (DMHU) are composite bodies that are mandated to ensure accountability and transparency in governance, improve quality of services, and facilitate local responsiveness. There is scant literature on the nature of functioning of these institutions in Odisha. This study aimed to assess the perception of RKS members about their roles, involvement and practices with respect to local decision making and management of DMHUs; it further examined perceptual and functional differences between priority and non-priority district set-ups; and identified predictors of involvement of RKS members in local governance of health units. As members of RKS, health service providers, officials in administrative/managerial role, elected representatives, and officials from other departments (including independent members) constituted our study sample. A total of 112 respondents were interviewed across 6 districts, through a multi-stage stratified random sampling; we used a semi-structured interview schedule that comprised mainly of close-ended and some open-ended questions. Descriptive and inferential statistics were used to compare 3 priority (PD) and 3 non-priority districts (NPD), categorized on the basis of Infant Mortality Rate (IMR) estimates of 2011 as proxy of population health. Governance, human resource management, financial management and quality improvement functions were studied in detail. Opinion about various individual and organizational factors in local self-governance and predictors of involvement were identified. The socio-demographic profile and composition of respondents were comparable between PD and NPD. Majority of respondents were 'satisfied' with their current roles in the governance of local health institutions. About one-fourth opined that the amount of funds allocated to RKS under National Health Mission (NHM

Electronic structure and local distortions in epitaxial ScGaN films

International Nuclear Information System (INIS)

Knoll, S M; Zhang, S; Rovezzi, M; Joyce, T B; Moram, M A

2014-01-01

High energy resolution fluorescence-detected x-ray absorption spectroscopy and density functional theory calculations were used to investigate the local bonding and electronic structure of Sc in epitaxial wurtzite-structure Sc x Ga 1−x N films with x ≤ 0.059. Sc atoms are found to substitute for Ga atoms, accompanied by a local distortion involving an increase in the internal lattice parameter u around the Sc atoms. The local bonding and electronic structure at Sc are not affected strongly by the strain state or the defect microstructure of the films. These data are consistent with theoretical predictions regarding the electronic structure of dilute Sc x Ga 1−x N alloys. (paper)

Local election: does bureaucracy become one of main political power?

Science.gov (United States)

Amin, Muryanto; Musthafa Sembiring, Walid

2018-03-01

This writing aims to analyze the emergence of bureaucracy as one of political power in local level after the local election is held in Indonesia. Due to information authorization, media network, and stable structure, the bureaucracy soon transforms into political power which can compete with the other political power at the local level. In Medan local election in 2010 and 2015 has evidently proven the power of bureaucracy network in winning the bureaucrat-background candidates. As methods of the research, the researcher held a Focus-Group Discussion (FGD) and had an in-depth interview with ten bureaucracy elites in Medan and local political elites. The observation and Focus-Group Discussion (FGD) are analyzed using qualitative analysis technique typology. The result states that the bureaucracy network in Medan has been used in a massive way as the political power of winning. The structure of bureaucracy – from the top to the low – is involved in the winning. The most governmental programs were applied to attract the mass’ sympathy toward the candidates. The bureaucratic proximity to media network is also used to do a campaign in a massive way. The conclusion of the research is that bureaucracy emerges as a new, massive, effective local political power in the local election.

The factors impacted to local contractor from Foreign Direct Investment in advancing economic hub development in Iskandar Malaysia

Science.gov (United States)

Syafiq Salim, Muhamad; Zakaria, Rozana; Aminuddin, Eeydzah; Hamid, Abdul Rahim Abdul; Abdullah, Redzuan; Shahzaib Khan, Jam

2018-04-01

Iskandar Malaysia is an advanced economic hub which is rapidly growing in the State of Johor. It has been an attractive place for Foreign Direct Investment (FDI) to invest. Many sectors are affected by the presence of FDI including the construction sector. This paper highlights the investigation on the effects of FDI to the local contractor in the Iskandar Malaysia Development. In this study, a questionnaire survey was carried out to gain the information on problems from internal factors and external factors that caused the limitation on involvement in FDI project by local contractors. 73 numbers of local contractor registered under CIDB in class G5, G6 and G7 are the respondents. Frequency analysis and Average Index Analysis are used for the results. This study provides the factors that impacted local construction players in Iskandar Malaysia Development. This study has portrayed that FDI plays a vital and significant role in spearheading the active involvement of local contractors in an urban sustainable development.

The non-differentiable solution for local fractional Laplace equation in steady heat-conduction problem

Directory of Open Access Journals (Sweden)

Chen Jie-Dong

2016-01-01

Full Text Available In this paper, we investigate the local fractional Laplace equation in the steady heat-conduction problem. The solutions involving the non-differentiable graph are obtained by using the characteristic equation method (CEM via local fractional derivative. The obtained results are given to present the accuracy of the technology to solve the steady heat-conduction in fractal media.

Local geomagnetic events associated with displacements on the san andreas fault.

Science.gov (United States)

Breiner, S; Kovach, R L

1967-10-06

The piezomagnetic properties of rock suggest that a change in subsurface stress will manifest itself as a change in the magnetic susceptibility and remanent magnetization and hence the local geomagnetic field. A differential array of magnetometers has been operating since late 1965 on the San Andreas fault in the search for piezomagnetic signals under conditions involving active fault stress. Local changes in the geomagnetic field have been observed near Hollister, California, some tens of hours preceding the onset of abrupt creep displacement on the San Andreas fault.

The role of private developers in local infrastructure provision in Malaysia

Science.gov (United States)

Salleh, Dani; Okinono, Otega

2016-08-01

Globally, the challenge of local infrastructure provision has attracted much debate amongst different nations including Malaysia, on how to achieve an effective and efficient infrastructural management. This approach therefore, has intensified the efforts of local authorities in incorporating private developers in their developmental agenda in attaining a sustainable infrastructural development in local areas. Basically, the knowledge of the need for adequate provision of local infrastructure is well understood by both local and private authorities. Likewise, the divergent opinions on the usage of private delivery services. Notwithstanding the common perception, significant loopholes have been identified on the most appropriate and ideal approach and practices to adopt in enhancing local infrastructure development. The study therefore examined the role of private developers in local infrastructure provision and procedure adopted by both local authorities and the privates sector in local infrastructure development. Data was obtained using the questionnaire through purposive sampling, administered to 22 local authorities and 16 developers which was descriptively analysed. Emanating from the study findings, the most frequently approved practices by local authorities are joint venture and complete public delivery systems. Likewise, negotiation was identified as a vital tool for stimulating the acquisition of local infrastructure provision. It was also discovered the one of the greatest challenge in promoting private sector involvement in local infrastructure development is due to unregulated-procedure. The study therefore recommends, there is need for local authorities to adopt a collective and integrated approach, nevertheless, cognisance and priority should be given to developing a well-structured and systematic process of local infrastructure provision and development.

Dark Skies Awareness Programs for the International Year of Astronomy: Involvement, Outcomes and Sustainability

Science.gov (United States)

Walker, Constance E.

2010-01-01

The preservation of dark skies is a growing global concern, yet it is one of the easiest environmental problems people can address on local levels. For this reason, the goal of the IYA Dark Skies Awareness Cornerstone Project is to raise public awareness of the impact of artificial lighting on local environments by getting people worldwide involved in a variety of programs. These programs provide resources on light pollution for new technologies like a presence in Second Life and podcasts, for local thematic events at national parks and observatory open houses, for international thematic events like International Dark Skies Week and Earth Hour, for a program in the arts like an international photo contest, for global citizen-science programs that measure night sky brightness worldwide, and for educational materials like a kit with a light shielding demonstration. These programs have been successfully used around the world during IYA to raise awareness of the effects of light pollution on public health, economic issues, ecological consequences, energy conservation, safety and security, and astronomy. The presentation will provide an update, take a look ahead at the project's sustainability, and describe how people can be involved in the future. Information about the programs is at www.darkskiesawareness.org.

Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy

International Nuclear Information System (INIS)

Douglas, James G.; Laramore, George E.; Austin-Seymour, Mary; Koh Wuijin; Stelzer, Keith; Griffin, Thomas W.

2000-01-01

Purpose: To examine the efficacy of fast neutron radiotherapy for the treatment of locally advanced and/or recurrent adenoid cystic carcinoma of the head and neck and to identify prognostic variables associated with local-regional control and survival. Methods and Materials: One hundred fifty-nine patients with nonmetastatic, previously unirradiated, locally advanced, and/or recurrent adenoid cystic carcinoma (ACC) of the head and neck region were treated with fast neutron radiotherapy during the years 1985-1997. One hundred fifty-one patients had either unresectable disease, or gross residual disease (GRD) after an attempted surgical extirpation. Eight patients had microscopic residual disease and were analyzed separately. Sixty-two percent of patients had tumors arising in minor salivary glands, 29% in major salivary glands, and 9% in other sites such as the lacrimal glands, tracheal-bronchial tree, etc. Fifty-five percent of patients were treated for postsurgical recurrent disease and 13% of patients had lymph node involvement at the time of treatment. The median duration of follow-up was 32 months (range 3-142 months). Actuarial curves for survival, cause-specific survival, local-regional control, and the development of distant metastases are presented for times out to 11 years. Results: The 5-year actuarial local-regional tumor control rate for the 151 patients with GRD was 57%; the 5-year actuarial overall survival rate was 72%; and the 5-year actuarial cause-specific survival rate was 77%. Variables associated with decreased local-regional control in the patients with GRD as determined by multivariate analysis included base of skull involvement (p < 0.01) and biopsy only versus an attempted surgical resection prior to treatment (p = 0.03). Patients without these negative factors had an actuarial local-regional control rate of 80% at 5 years. Patients with microscopic residual disease (n = 8) had a 5-year actuarial local-regional control rate of 100%. Base of

Functional genomics of physiological plasticity and local adaptation in killifish.

Science.gov (United States)

Whitehead, Andrew; Galvez, Fernando; Zhang, Shujun; Williams, Larissa M; Oleksiak, Marjorie F

2011-01-01

Evolutionary solutions to the physiological challenges of life in highly variable habitats can span the continuum from evolution of a cosmopolitan plastic phenotype to the evolution of locally adapted phenotypes. Killifish (Fundulus sp.) have evolved both highly plastic and locally adapted phenotypes within different selective contexts, providing a comparative system in which to explore the genomic underpinnings of physiological plasticity and adaptive variation. Importantly, extensive variation exists among populations and species for tolerance to a variety of stressors, and we exploit this variation in comparative studies to yield insights into the genomic basis of evolved phenotypic variation. Notably, species of Fundulus occupy the continuum of osmotic habitats from freshwater to marine and populations within Fundulus heteroclitus span far greater variation in pollution tolerance than across all species of fish. Here, we explore how transcriptome regulation underpins extreme physiological plasticity on osmotic shock and how genomic and transcriptomic variation is associated with locally evolved pollution tolerance. We show that F. heteroclitus quickly acclimate to extreme osmotic shock by mounting a dramatic rapid transcriptomic response including an early crisis control phase followed by a tissue remodeling phase involving many regulatory pathways. We also show that convergent evolution of locally adapted pollution tolerance involves complex patterns of gene expression and genome sequence variation, which is confounded with body-weight dependence for some genes. Similarly, exploiting the natural phenotypic variation associated with other established and emerging model organisms is likely to greatly accelerate the pace of discovery of the genomic basis of phenotypic variation.

The Prognostic Value of Circumferential Resection Margin Involvement in Patients with Extraperitoneal Rectal Cancer.

Science.gov (United States)

Shin, Dong Woo; Shin, Jin Yong; Oh, Sung Jin; Park, Jong Kwon; Yu, Hyeon; Ahn, Min Sung; Bae, Ki Beom; Hong, Kwan Hee; Ji, Yong Il

2016-04-01

The prognostic influence of circumferential resection margin (CRM) status in extraperitoneal rectal cancer probably differs from that of intraperitoneal rectal cancer because of its different anatomical and biological behaviors. However, previous reports have not provided the data focused on extraperitoneal rectal cancer. Therefore, the aim of this study was to examine the prognostic significance of the CRM status in patients with extraperitoneal rectal cancer. From January 2005 to December 2008, 248 patients were treated for extraperitoneal rectal cancer and enrolled in a prospectively collected database. Extraperitoneal rectal cancer was defined based on tumors located below the anterior peritoneal reflection, as determined intraoperatively by a surgeon. Cox model was used for multivariate analysis to examine risk factors of recurrence and mortality in the 248 patients, and multivariate logistic regression analysis was performed to identify predictors of recurrence and mortality in 135 patients with T3 rectal cancer. CRM involvement for extraperitoneal rectal cancer was present in 29 (11.7%) of the 248 patients, and was the identified predictor of local recurrence, overall recurrence, and death by multivariate Cox analysis. In the 135 patients with T3 cancer, CRM involvement was found to be associated with higher probability of local recurrence and mortality. In extraperitoneal rectal cancer, CRM involvement is an independent risk factor of recurrence and survival. Based on the results of the present study, it seems that CRM involvement in extraperitoneal rectal cancer is considered an indicator for (neo)adjuvant therapy rather than conventional TN status.

Local food policies can help promote local foods and improve health: a case study from the Federated States of Micronesia.

Science.gov (United States)

Englberger, Lois; Lorens, Adelino; Pretrick, Moses; Tara, Mona J; Johnson, Emihner

2011-11-01

The Federated States of Micronesia (FSM) and other countries throughout the Pacific are facing an epidemic of non-communicable disease health problems. These are directly related to the increased consumption of unhealthy imported processed foods, the neglect of traditional food systems, and lifestyle changes, including decreased physical activity. The FSM faces the double burden of malnutrition with both non-communicable diseases and micronutrient deficiencies, including vitamin A deficiency and anemia. To help increase the use of traditional island foods and improve health, the Island Food Community of Pohnpei has initiated a program in the FSM to support and promote local food policies, along with its Go Local awareness campaign. Such local food policies are defined broadly and include individual and family commitments, community group local food policies and policies established by government, including presidential proclamations and increased taxation on soft drinks. The aim of this paper is to describe this work. An inter-agency, community- and research-based, participatory and media approach was used. Partners are both non-governmental and governmental. The use of continuing awareness work along with local food policy establishment and the acknowledgement of the individuals and groups involved are essential. The work is still in the preliminary stage but ad hoc examples show that this approach has had success in increased awareness on health issues and improving dietary intake on both an individual and group basis. This indicates that further use of local food policies could have an instrumental impact in FSM as well as other Pacific Island countries in promoting local foods and improving dietary intake and health, including the control of non-communicable diseases and other dietary-related health problems.

Local Firms, Place and Social Responsibility

DEFF Research Database (Denmark)

Larsen, Jacob Norvig; Jensen, Jesper Ole

2010-01-01

Urban regeneration combining integrated and place-based approaches increasingly aims to involve private companies in social activities in neighbourhood revitalisation. The study examines three case studies in selected urban neighbourhoods in differently sized Danish towns and cities. The cases...... are investigated by means of field observations and interviews and supplemented with official statistics and planning documents. Findings show that in case of the big city neighbourhood, there is considerable incongruity between the views of public planners and company managers as regards what is at issue...... companies displayed much more attachment to the local place....

Outcomes following treatment for patients with cranial nerve involvement from nasopharyngeal cancer

International Nuclear Information System (INIS)

Yap, Mei Ling; Choo, Bok Ai; Chan, Yiong Huak; Lu, Jay Jiade; Lee, Khai Mun; Tham, Ivan WK

2012-01-01

Patients with locally advanced nasopharyngeal carcinoma (NPC) commonly present with cranial nerve (CN) involvement, which can cause significant morbidity. We aimed to characterise the pattern of involvement and outcomes of these patients, as well as determine if these differed according to the mode of diagnosis. Patients were included if they had non-distant metastatic NPC, presented with CN involvement and completed radiotherapy treatment between 2002 and 2008. The clinical response was categorised as complete response, partial response, stable or progressive disease. The radiological response was assessed using the Response Evaluation Criteria in Solid Tumors criteria. The loco-regional control and disease-free survival rates were estimated with the Kaplan–Meier method. Forty-seven patients fulfilled the inclusion criteria. CN lesions were diagnosed on clinical examination in 15% of patients, radiologically in 40% and both clinically and radiologically in 45% of patients. A complete or partial response of the CN lesions was seen clinically in 82% and radiologically in 95% of patients. The 3-year local relapse free survival was 64.3%, distant metastasis-free survival was 46.1% and overall survival was 82.8%. There were no differences in outcomes between patients with clinically versus radiologically detected CN lesions. Most of these patients are likely to undergo clinical and/or radiological resolution of the nerve lesions following chemoradiotherapy, but the outcome was not determined by the mode of diagnosis (radiological or clinical).

LOCAL COMMUNITY ATTITUDES TOWARDS THE IMPACT OF TOURISM ON PROSTITUTION

Directory of Open Access Journals (Sweden)

Anallely BELLO

2011-12-01

Full Text Available Tourism has been commonly related to prostitution. However, very few studies have evidenced this relationship in different contexts. Several studies on local community attitudes towards tourism impacts have briefly assessed the increase of prostitution as one of several indicators of social change. Due to the importance that such relationship has both for tourism impact management and social development, the impact of tourism on prostitution should be studied in detail. This study explores the ‘responsibility' of tourism on the increase of prostitution in an urban destination as perceived by local residents. It was found that while local community residents do not perceive tourism as the only causing factor, the tourist involvement in commercial sex does exist, but it is commonly an incidental rather than a purposive experience.

Instantaneous Non-Local Computation of Low T-Depth Quantum Circuits

DEFF Research Database (Denmark)

Speelman, Florian

2016-01-01

-depth of a quantum circuit, able to perform non-local computation of quantum circuits with a (poly-)logarithmic number of layers of T gates with quasi-polynomial entanglement. Our proofs combine ideas from blind and delegated quantum computation with the garden-hose model, a combinatorial model of communication......Instantaneous non-local quantum computation requires multiple parties to jointly perform a quantum operation, using pre-shared entanglement and a single round of simultaneous communication. We study this task for its close connection to position-based quantum cryptography, but it also has natural...... applications in the context of foundations of quantum physics and in distributed computing. The best known general construction for instantaneous non-local quantum computation requires a pre-shared state which is exponentially large in the number of qubits involved in the operation, while efficient...

German guidelines for the diagnosis and therapy of localized scleroderma.

Science.gov (United States)

Kreuter, Alexander; Krieg, Thomas; Worm, Margitta; Wenzel, Jörg; Moinzadeh, Pia; Kuhn, Annegret; Aberer, Elisabeth; Scharffetter-Kochanek, Karin; Horneff, Gerd; Reil, Emma; Weberschock, Tobias; Hunzelmann, Nicolas

2016-02-01

Localized scleroderma designates a heterogeneous group of sclerotic skin disorders. Depending on the subtype, severity, and site affected, adjacent structures such as adipose tissue, muscles, joints, and bones may be involved. This is an update of the existing German AWMF (Association of the Scientific Medical Societies in Germany) guidelines (classification: S2k). These guidelines provide an overview of the definition, epidemiology, classification, pathogenesis, laboratory workup, histopathology, clinical scoring systems, as well as imaging and device-based workup of localized scleroderma. Moreover, consensus-based recommendations are given on the management of localized scleroderma depending on its clinical subtype. Treatment recommendations are presented in a therapeutic algorithm. No financial support was given by any pharmaceutical company. The guidelines are valid until July 2019. © 2016 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.

Hmong Political Involvement in St. Paul, Minnesota and Fresno, California

Directory of Open Access Journals (Sweden)

Yang Lor

2010-01-01

Full Text Available Over the past several years, Hmong in the United States have gained prominence for their increasing involvement in politics. Most of the attention has understandably focused on Fresno, California and St. Paul, Minnesota, home to the two largest Hmong populations in this country. While the Hmong communities in both cities are similar in size and have made significant political progress as evidenced by the election of Hmong candidates, the Hmong community in St. Paul has made greater inroads in the political realm. In addition to the elections of two Hmong candidates to the Minnesota State Legislature and two to the St. Paul School Board, the Hmong community in St. Paul has been able to engage local and state governments in Minnesotato address issues that affect the Hmong community. Through interviews, census data, and newspaper coverage of political campaigns, I show that Hmong in St. Paul have achieved greaterrepresentation in local and state governments and received greater support from government officials than Hmong in Fresno because Minnesota offers a social, economic, and politicalcontext that is favorable to fostering Hmong political involvement. Compared to Hmong in Fresno, Hmong in St. Paul have higher levels of socioeconomic resources and are more visible given their large size relative to other minority groups. They live in a region with consistently high levels of political participation and have political candidates who devote resources to mobilizing the Hmong community. Moreover, the Hmong vote has been critical to the success of Hmong candidates in St. Paul, an indication of the increasing political clout of the Hmong community there and a major reason why politicians in Minnesota are more willing to respond toissues that affect the Hmong community. Overall, this study highlights the importance of local and regional context in understanding the political incorporation of immigrants.

Scientists Involved in K-12 Education

Science.gov (United States)

Robigou, V.

2004-12-01

The publication of countless reports documenting the dismal state of science education in the 1980s, and the Third International Mathematics and Science Study (TIMMS) report (1996) called for a wider involvement of the scientific community in K-12 education and outreach. Improving science education will not happen without the collaboration of educators and scientists working in a coordinated manner and it requires a long-term, continuous effort. To contribute effectively to K-12 education all scientists should refer to the National Science Education Standards, a set of policies that guide the development of curriculum and assessment. Ocean scientists can also specifically refer to the COSEE recommendations (www.cosee.org) that led to the creation of seven regional Centers for Ocean Sciences Education Excellence. Scientists can get involved in K-12 education in a multitude of ways. They should select projects that will accommodate time away from their research and teaching obligations, their talent, and their interest but also contribute to the education reform. A few examples of effective involvement are: 1) collaborating with colleagues in a school of education that can lead to better education of all students and future teachers, 2) acting as a resource for a national program or a local science fair, 3) serving on the advisory board of a program that develops educational material, 4) speaking out at professional meetings about the value of scientists' involvement in education, 5) speaking enthusiastically about the teaching profession. Improving science education in addition to research can seem a large, overwhelming task for scientists. As a result, focusing on projects that will fit the scientist's needs as well as benefit the science reform is of prime importance. It takes an enormous amount of work and financial and personnel resources to start a new program with measurable impact on students. So, finding the right opportunity is a priority, and stepping

Stakeholder involvement and public outreach at two Department of Energy sites

International Nuclear Information System (INIS)

Gray, R.H.

1996-01-01

Outreach efforts at two U.S. Department of Energy sites (i.e., the Hanford Site in southeastern Washington and Pantex Plant in the Texas panhandle) have involved a broad spectrum of communications media, including technical presentations and articles, information brochures and fact sheets, video productions; interactive exhibits; presentations at civic and other public meetings; and proactive interactions with the news media, regulators and concerned citizens. In addition, representatives of local communities operate offsite environmental monitoring stations and Native Americans are involved in studying cultural resources, fisheries, and other issues at Hanford, and a program to obtain environmental samples from neighbors property is underway at Pantex. All major environmental programs (e.g., the reconstruction of past radiological doses to offsite human populations at Hanford) are conducted with open public participation, the Pantex Plant has opened an Information office in Amarillo, Texas, and both sites now have Citizen's Advisory Boards. This presentation describes Hanford and Pantex public outreach and involvement efforts, our successes and failures, and the lessons learned

The Politics of Organizational Reform: An Exploratory Study of the Effects of Corporate Management on Selected Aspects of the Education Service in English Local Government.

Science.gov (United States)

Housego, Ian E.

In 1974 local government in England underwent external and internal reform. The external reforms involved changes in governmental structures and functions, while the internal reforms involved the introduction of "corporate management," a concept stressing more centralized administration and fewer local executive bodies. This paper first…

Local Health Integration Networks: Build on their purpose.

Science.gov (United States)

MacLeod, Hugh

2015-11-01

This article provides a high-level overview on the creation of Local Health Integration Networks (LHINs) and illustrates the complexities involved in their implementation. To understand regional structures such as LHINs, one must understand the context in which design and execution takes place. The article ends with a commentary on how Ontario is performing post-LHINs and discusses next steps. © 2015 The Canadian College of Health Leaders.

Localized nodular synovitis of the infrapatellar fat pad

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Jong-Hoon Park

2013-01-01

Full Text Available We report a case of localized nodular synovitis of the infrapatellar fat pad impinging on the patellofemoral joint causing limitation of extension. Arthroscopy involved use of a superolateral portal because location of lesion hindered access via a conventional anterior portal. The infrapatellar mass impinged in the patellofemoral joint upon knee extension and retracted upon flexion. Superior-superior triangulation allowed for complete excision of the mass.

Implementing European climate adaptation policy. How local policymakers react to European policy

Directory of Open Access Journals (Sweden)

Thomas Hartmann

2015-04-01

Full Text Available EU policy and projects have an increasing influence on policymaking for climate adaptation. This is especially evident in the development of new climate adaptation policies in transnational city networks. Until now, climate adaptation literature has paid little attention to the influence that these EU networks have on the adaptive capacity in cities. This paper uses two Dutch cities as an empirical base to evaluate the influence of two EU climate adaptation projects on both the experience of local public officials and the adaptive capacity in the respective cities. The main conclusion is that EU climate adaptation projects do not automatically lead to an increased adaptive capacity in the cities involved. This is due to the political opportunistic use of EU funding, which hampers the implementation of climate adaptation policies. Furthermore, these EU projects draw attention away from local network building focused on the development and implementation of climate adaptation policies. These factors have a negative cumulative impact on the performance of these transnational policy networks at the adaptive capacity level in the cities involved. Therefore, in order to strengthen the adaptive capacity in today’s European cities, a context-specific, integrative approach in urban planning is needed at all spatial levels. Hence, policy entrepreneurs should aim to create linkage between the issues in the transnational city network and the concerns in local politics and local networks.

The work of local healthcare innovation: a qualitative study of GP-led integrated diabetes care in primary health care.

Science.gov (United States)

Foster, Michele; Burridge, Letitia; Donald, Maria; Zhang, Jianzhen; Jackson, Claire

2016-01-14

Service delivery innovation is at the heart of efforts to combat the growing burden of chronic disease and escalating healthcare expenditure. Small-scale, locally-led service delivery innovation is a valuable source of learning about the complexities of change and the actions of local change agents. This exploratory qualitative study captures the perspectives of clinicians and managers involved in a general practitioner-led integrated diabetes care innovation. Data on these change agents' perspectives on the local innovation and how it works in the local context were collected through focus groups and semi-structured interviews at two primary health care sites. Transcribed data were analysed thematically. Normalization Process Theory provided a framework to explore perspectives on the individual and collective work involved in putting the innovation into practice in local service delivery contexts. Twelve primary health care clinicians, hospital-based medical specialists and practice managers participated in the study, which represented the majority involved in the innovation at the two sites. The thematic analysis highlighted three main themes of local innovation work: 1) trusting and embedding new professional relationships; 2) synchronizing services and resources; and 3) reconciling realities of innovation work. As a whole, the findings show that while locally-led service delivery innovation is designed to respond to local problems, convincing others to trust change and managing the boundary tensions is core to local work, particularly when it challenges taken-for-granted practices and relationships. Despite this, the findings also show that local innovators can and do act in both discretionary and creative ways to progress the innovation. The use of Normalization Process Theory uncovered some critical professional, organizational and structural factors early in the progression of the innovation. The key to local service delivery innovation lies in building

Dual localized mitochondrial and nuclear proteins as gene expression regulators in plants?

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Philippe eGiegé

2012-09-01

Full Text Available Mitochondria heavily depend on the coordinated expression of both mitochondrial and nuclear genomes because some of their most significant activities are held by multi-subunit complexes composed of both mitochondrial and nuclear encoded proteins. Thus, precise communication and signaling pathways are believed to exist between the two compartments. Proteins dual localized to both mitochondria and the nucleus make excellent candidates for a potential involvement in the envisaged communication. Here, we review the identified instances of dual localized nucleo-mitochondrial proteins with an emphasis on plant proteins and discuss their functions, which are seemingly mostly related to gene expression regulation. We discuss whether dual localization could be achieved by dual targeting and / or by re-localization and try to apprehend the signals required for the respective processes. Finally, we propose that in some instances, dual localized mitochondrial and nuclear proteins might act as retrograde signaling molecules for mitochondrial biogenesis.

Aspects of Professional Training at Local and Central Public Administration Institutions from Romania

Directory of Open Access Journals (Sweden)

Tudorel ANDREI

2010-02-01

Full Text Available The article aims to identify some characteristics  of the training process of the central and local  public administration employees. For comments  formulation we used the information obtained  from the central and local public administration  civil servants, which was collected by applying a  statistical questionnaire. The study emphasizes a  series of positive and negative aspects related to  the application of some instruments for consulting  the actors involved in the training process, the  curricula content of the training programs  addressing the public sector personnel at central  and local levels.  

Comparison of aquifer characteristics derived from local and regional aquifer tests.

Science.gov (United States)

Randolph, R.B.; Krause, R.E.; Maslia, M.L.

1985-01-01

A comparison of the aquifer parameter values obtained through the analysis of a local and a regional aquifer test involving the same area in southeast Georgia is made in order to evaluate the validity of extrapolating local aquifer-test results for use in large-scale flow simulations. Time-drawdown and time-recovery data were analyzed by using both graphical and least-squares fitting of the data to the Theis curve. Additionally, directional transmissivity, transmissivity tensor, and angle of anisotropy were computed for both tests. -from Authors Georgia drawdown transmissivity regional aquifer tests

Identification and Expression Analysis of Medicago truncatula Isopentenyl Transferase Genes (IPTs Involved in Local and Systemic Control of Nodulation

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Mahboobeh Azarakhsh

2018-03-01

Full Text Available Cytokinins are essential for legume plants to establish a nitrogen-fixing symbiosis with rhizobia. Recently, the expression level of cytokinin biosynthesis IPTs (ISOPENTENYLTRANSFERASES genes was shown to be increased in response to rhizobial inoculation in Lotus japonicus, Medicago truncatula and Pisum sativum. In addition to its well-established positive role in nodule primordium initiation in root cortex, cytokinin negatively regulates infection processes in the epidermis. Moreover, it was reported that shoot-derived cytokinin inhibits the subsequent nodule formation through AON (autoregulation of nodulation pathway. In L. japonicus, LjIPT3 gene was shown to be activated in the shoot phloem via the components of AON system, negatively affecting nodulation. However, in M. truncatula, the detailed analysis of MtIPTs expression, both in roots and shoots, in response to nodulation has not been performed yet, and the link between IPTs and AON has not been studied so far. In this study, we performed an extensive analysis of MtIPTs expression levels in different organs, focusing on the possible role of MtIPTs in nodule development. MtIPTs expression dynamics in inoculated roots suggest that besides its early established role in the nodule primordia development, cytokinin may be also important for later stages of nodulation. According to expression analysis, MtIPT3, MtIPT4, and MtIPT5 are activated in the shoots in response to inoculation. Among these genes, MtIPT3 is the only one the induction of which was not observed in leaves of the sunn-3 mutant defective in CLV1-like kinase, the key component of AON, suggesting that MtIPT3 is activated in the shoots in an AON-dependent manner. Taken together, our findings suggest that MtIPTs are involved in the nodule development at different stages, both locally in inoculated roots and systemically in shoots, where their expression can be activated in an AON-dependent manner.

Local dose assessment for a contaminated wound

International Nuclear Information System (INIS)

Piechowski, J.; Chaptinel, Y.

2004-01-01

Contaminated wounds present a great variability concerning the type of lesion. Assessment of the local dose is one amongst other factors for a decision as to the surgical operation. A simple model has been used to calculate the doses in a representative volume, that of a phalanx for instance. The dose rates are given for current radionuclides. The method of calculation is enough simple in order to allow the practitioners to use it in situations involving other radionuclides. Committed dose depends on the biological half-life which can be estimated from the local measurements. Some examples of calculation of committed dose are given considering half-lives characteristic of the compound. Transposition of the dose to the local risk is easy for the non-stochastic risk. Conversely, this is not the case for the risk of chronic inflammation or cancer. The latter question could only be solved by a feedback based on the analysis of real till now observed cases, nevertheless taking into account the fact that the available data are generally not so easy to make use for establishing an unquestionable dose - effect relation. A critical issue remains open as to the use of these doses for their comparison to the regulatory limits and for the subsequent decisions in case of exceeding the limits. The actual impact of an irradiation, especially by alpha particles, is not linked to the calculated dose in a simple and direct way. This question needs further consideration and perhaps a practical guide concerning this topic would be useful. The anatomical (surgical side effects), psychological and professional consequences should have a large weight relatively to the doses, obviously except for the cases, involving actually large contamination. (authors)

Exploring local knowledge and perceptions on zoonoses among pastoralists in northern and eastern Tanzania.

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Peter Ernest Mangesho

2017-02-01

Full Text Available Zoonoses account for the most commonly reported emerging and re-emerging infectious diseases in Sub-Saharan Africa. However, there is limited knowledge on how pastoral communities perceive zoonoses in relation to their livelihoods, culture and their wider ecology. This study was carried out to explore local knowledge and perceptions on zoonoses among pastoralists in Tanzania.This study involved pastoralists in Ngorongoro district in northern Tanzania and Kibaha and Bagamoyo districts in eastern Tanzania. Qualitative methods of focus group discussions, participatory epidemiology and interviews were used. A total of 223 people were involved in the study. Among the pastoralists, there was no specific term in their local language that describes zoonosis. Pastoralists from northern Tanzania possessed a higher understanding on the existence of a number of zoonoses than their eastern districts' counterparts. Understanding of zoonoses could be categorized into two broad groups: a local syndromic framework, whereby specific symptoms of a particular illness in humans concurred with symptoms in animals, and the biomedical framework, where a case definition is supported by diagnostic tests. Some pastoralists understand the possibility of some infections that could cross over to humans from animals but harm from these are generally tolerated and are not considered as threats. A number of social and cultural practices aimed at maintaining specific cultural functions including social cohesion and rites of passage involve animal products, which present zoonotic risk.These findings show how zoonoses are locally understood, and how epidemiology and biomedicine are shaping pastoralists perceptions to zoonoses. Evidence is needed to understand better the true burden and impact of zoonoses in these communities. More studies are needed that seek to clarify the common understanding of zoonoses that could be used to guide effective and locally relevant interventions

Exploring local knowledge and perceptions on zoonoses among pastoralists in northern and eastern Tanzania.

Science.gov (United States)

Mangesho, Peter Ernest; Neselle, Moses Ole; Karimuribo, Esron D; Mlangwa, James E; Queenan, Kevin; Mboera, Leonard E G; Rushton, Jonathan; Kock, Richard; Häsler, Barbara; Kiwara, Angwara; Rweyemamu, Mark

2017-02-01

Zoonoses account for the most commonly reported emerging and re-emerging infectious diseases in Sub-Saharan Africa. However, there is limited knowledge on how pastoral communities perceive zoonoses in relation to their livelihoods, culture and their wider ecology. This study was carried out to explore local knowledge and perceptions on zoonoses among pastoralists in Tanzania. This study involved pastoralists in Ngorongoro district in northern Tanzania and Kibaha and Bagamoyo districts in eastern Tanzania. Qualitative methods of focus group discussions, participatory epidemiology and interviews were used. A total of 223 people were involved in the study. Among the pastoralists, there was no specific term in their local language that describes zoonosis. Pastoralists from northern Tanzania possessed a higher understanding on the existence of a number of zoonoses than their eastern districts' counterparts. Understanding of zoonoses could be categorized into two broad groups: a local syndromic framework, whereby specific symptoms of a particular illness in humans concurred with symptoms in animals, and the biomedical framework, where a case definition is supported by diagnostic tests. Some pastoralists understand the possibility of some infections that could cross over to humans from animals but harm from these are generally tolerated and are not considered as threats. A number of social and cultural practices aimed at maintaining specific cultural functions including social cohesion and rites of passage involve animal products, which present zoonotic risk. These findings show how zoonoses are locally understood, and how epidemiology and biomedicine are shaping pastoralists perceptions to zoonoses. Evidence is needed to understand better the true burden and impact of zoonoses in these communities. More studies are needed that seek to clarify the common understanding of zoonoses that could be used to guide effective and locally relevant interventions. Such studies should

Understanding local water conflict and cooperation: The case of Namwala District, Zambia

Science.gov (United States)

Funder, Mikkel; Mweemba, Carol; Nyambe, Imasiku; van Koppen, Barbara; Ravnborg, Helle Munk

Understanding the nature of water conflict and cooperation is a crucial element in water governance within Integrated Water Resources Management (IWRM). Much of the recent attention to the issue has however focused on transboundary aspects, while we know rather less about the nature and dynamics of local water conflict and cooperation. Drawing on the work of the collaborative Competing for Water Research Programme, this article presents selected findings from a quantitative and qualitative mapping and exploration of water conflict and cooperation events in Namwala District of Zambia. It is found that local water competition situations often involve both conflictive and cooperative events in a dynamic succession of each other, but also that the majority of events are conflictive, and that they primarily take place between different types of water uses, and less frequently among the same types of uses. There is a distinct tendency for both conflictive and cooperative events to originate in the dry season, and many events are associated with water infrastructure development, particularly boreholes. The study found that most conflictive and cooperative events took place within individual communities, and only to a lesser extent between two or more communities or between districts. While third parties are involved in some events, these are primarily local village institutions such as Headmen. The article concludes by discussing the implications of these findings for local water governance, including the need to ensure that the very localized nature of such conflict and cooperation events is taken into consideration in the institutional development of IWRM.

IMMUNOLOGICAL MECHANISMS OF LOCAL INFLAMMATION

Directory of Open Access Journals (Sweden)

V. A. Chereshnev

2011-01-01

Full Text Available Abstract.  The  lecture  presents  current  data,  as  well  as  authors’  view  to  the  issue  of  immune  system involvement into inflammation. General physiological principles of immune system functioning are considered in details. Immunological mechanisms of local inflammation and participation of immune system components are analyzed with regard of protective/adaptive reactions in inflammatory foci. Original formulations of basic concepts are presented from the viewpoint of pathophysiology, immunopathology and clinical immunology, as being applied to the issues discussed. (Med. Immunol., 2011, vol. 13, N 6, pp 557-568

Local Monopsony Power in the Market for Broilers - Evidence from a Farm Survey

OpenAIRE

Key, Nigel D.; MacDonald, James M.

2008-01-01

The exercise of monopsony power by broiler processing firms is plausible because production occurs within localized complexes, which limits the number of integrators with whom growers can contract. In addition, growers face distinct hold-up risks as broiler production requires a substantial investment in specific assets and most production contracts do not involve long-term purchasing commitments by integrators. This paper provides an initial exploration of the links between the local concent...

New interaction paths in the energy landscape: the role of local energy initiatives

OpenAIRE

de Boer, Jessica; Zuidema, Christian; Gugerell, Katharina

2018-01-01

Energy transition is an encompassing process which not only involves the energy system but also the landscape in which the energy system is embedded. Renewable energy is triggering new interactions with local landscapes in physical, socio-economic and institutional senses. We capture these interactions using the energy landscape concept, which expresses the interdependence of the energy system with the landscape. We aim to understand whether and how local energy initiatives facilitate this in...

The Impact of Japanese Corporate Transnationalism on Men's Involvement in Family Life and Relationships

Science.gov (United States)

Yasuike, Akiko

2011-01-01

This study examines the ways in which Japanese corporate transnationalism affects husbands' involvement in family life and marital relationships primarily from a perspective of wives. It is based on interviews with 22 Japanese wives and 4 husbands. Studies of Japanese corporate transnationalism treat men as mere supervisors to local workers or…

Magnetic forces and localized resonances in electron transfer through quantum rings.

Science.gov (United States)

Poniedziałek, M R; Szafran, B

2010-11-24

We study the current flow through semiconductor quantum rings. In high magnetic fields the current is usually injected into the arm of the ring preferred by classical magnetic forces. However, for narrow magnetic field intervals that appear periodically on the magnetic field scale the current is injected into the other arm of the ring. We indicate that the appearance of the anomalous-non-classical-current circulation results from Fano interference involving localized resonant states. The identification of the Fano interference is based on the comparison of the solution of the scattering problem with the results of the stabilization method. The latter employs the bound-state type calculations and allows us to extract both the energy of metastable states localized within the ring and the width of resonances by analysis of the energy spectrum of a finite size system as a function of its length. The Fano resonances involving states of anomalous current circulation become extremely narrow on both the magnetic field and energy scales. This is consistent with the orientation of the Lorentz force that tends to keep the electron within the ring and thus increases the lifetime of the electron localization within the ring. Absence of periodic Fano resonances in electron transfer probability through a quantum ring containing an elastic scatterer is also explained.

Labeled bleomycin as a tumor localizing agent

International Nuclear Information System (INIS)

Vos, C.M.

1982-01-01

The antitumor antibiotics bleomycins labeled with 57 Co are known to possess excellent tumor localizing properties but the rather long halflife of 57 Co prevents its use in clinical routine. It is therefore desirable to label cobalt-bleomycin with a more suitable radionuclide, e.g. 123 I. This thesis reports on further studies on cobalt-bleomycin. It appears from the studies on the structure of cobalt-bleomycin described in this thesis (Chapter B), that cobalt is able to form different complexes with bleomycin (the forms I and II). The difference in structure is not clear, but the biological behavior of both forms is studied (Chapter C). In Chapter D the iodination of cobalt-bleomycin is described. Iodination of free bleomycin yields a product with bad tumor localizing properties, and straight-on iodination of cobalt-bleomycin is prevented by the presence of cobalt. To retain the good tumor-localizing properties of cobalt-bleomycin, possibilities were explored to incorporate the iodine in the terminal amine (a side chain, not involved in complexation). Alkylation of cobalt-bleomycin demethyl A 2 with N-bromoacetyl-3-iodoaniline yielded a product; unfortunately this product possessed bad tumor localizing properties and moreover, was not stable in vivo. The structure of a possibly successful iodinated cobalt-bleomycin is outlined but could not be realized during this research. (Auth.)

Interaction of Number Magnitude and Auditory Localization.

Science.gov (United States)

Golob, Edward J; Lewald, Jörg; Jungilligens, Johannes; Getzmann, Stephan

2016-01-01

The interplay of perception and memory is very evident when we perceive and then recognize familiar stimuli. Conversely, information in long-term memory may also influence how a stimulus is perceived. Prior work on number cognition in the visual modality has shown that in Western number systems long-term memory for the magnitude of smaller numbers can influence performance involving the left side of space, while larger numbers have an influence toward the right. Here, we investigated in the auditory modality whether a related effect may bias the perception of sound location. Subjects (n = 28) used a swivel pointer to localize noise bursts presented from various azimuth positions. The noise bursts were preceded by a spoken number (1-9) or, as a nonsemantic control condition, numbers that were played in reverse. The relative constant error in noise localization (forward minus reversed speech) indicated a systematic shift in localization toward more central locations when the number was smaller and toward more peripheral positions when the preceding number magnitude was larger. These findings do not support the traditional left-right number mapping. Instead, the results may reflect an overlap between codes for number magnitude and codes for sound location as implemented by two channel models of sound localization, or possibly a categorical mapping stage of small versus large magnitudes. © The Author(s) 2015.

Increasing Business and Parental Involvement in Grades 4-7 by Forming Partnerships between School and Local Businesses.

Science.gov (United States)

Hinson, Kay S.

This paper describes a practicum designed to increase parent and business involvement in the educational experiences of students in grades 4-7 at a rural school in the southeastern United States. Teacher surveys and other data indicated that the students had very little experience or understanding of the business world in which they eventually…

Locally Motivated GLOBE Investigations - A Key to Success

Science.gov (United States)

Washburne, J. C.; Geery, W.

2003-12-01

The GLOBE program was set up to help students make a core set of environmental observations at or near their schools, report their data through the internet to share with other students and scientists, analyze their data both locally and globally, and use this knowledge to form a better understanding of their environment. While the GLOBE program has been successful promoting more meaningful data collection, many of the tools and much of the infrastructure available to schools to synthesize their observations are underused. Schools that integrate GLOBE protocols with locally motivated investigations are more likely to implement the higher-order analysis and synthesis components of the program. Indicators of a successful observational program are things like measurement persistence, high data quality, and regular data. Participation in community forums and student-based research projects are evidence of a successful integrated program. A locally motivated issue allows a school to mold their GLOBE investigations around a multi-faceted question that they have first-hand knowledge of, that is both relevant and engaging to their students, and that can be supported by local expertise. In contrast, many GLOBE investigations are designed around abstract, non-site specific, narrowly focused and externally analyzed questions that limit local involvement and motivation. The main focus of this presentation is a few case histories of successful local investigations that incorporated GLOBE soil and air temperature data-logger measurements. The main example is drawn from Mr. Geery's fifth grade class investigation of why temperature differences exist between a local river bottom area and the school, which is located several kilometers away and 100 meters higher.

ASPECTS REGARDING IMPLICATIONS OF ASSOCIATIVE STRUCTURES FOR LOCAL DEVELOPMENT IN PROMOTING AND STRENGTHENING OF MULTILEVEL GOVERNANCE

Directory of Open Access Journals (Sweden)

Mihai Cristian APOSTOLACHE

2014-12-01

Full Text Available The need for the development of local communities in terms of economic and social policy-making requires finding answers institutional and public policy context in which the company is located. More and more the focus is on partnership and cooperation between the various actors of public life, on the involvement of private capital in local investment, on the establishment of companies to boost the joint venture or the establishment of local action groups to train both local public administration, the local economic environment, local non -governmental entities and other persons concerned in the design, implementation and completion of local development projects financed from European funds. The projects for local communities will receive support from the increasingly pronounced from the European Union, having regard to the fact that through the development of local communities will strengthen the European project.

String-localized quantum fields and modular localization

Energy Technology Data Exchange (ETDEWEB)

Mund, J. [Juiz de Fora Univ., MG (Brazil). Dept. de Fisica; Schroer, B. [FU-Berlin, Berlin (Germany). Inst. fuer Theoretische Physik; Yngvason, J. [Erwin Schroedinger Institute for Mathematical Physics, Vienna (Austria)

2005-12-15

We study free, covariant, quantum (Bose) fields that are associated with irreducible representations of the Poincare group and localized in semi-infinite strings extending to spacelike infinity. Among these are fields that generate the irreducible representations of mass zero and infinite spin that are known to be incompatible with point-like localized fields. For the massive representation and the massless representations of finite helicity, all string-localized free fields can be written as an integral, along the string, of point-localized tensor or spinor fields. As a special case we discuss the string-localized vector fields associated with the point-like electromagnetic field and their relation to the axial gauge condition in the usual setting. (author)

String-localized quantum fields and modular localization

International Nuclear Information System (INIS)

Mund, J.

2005-12-01

We study free, covariant, quantum (Bose) fields that are associated with irreducible representations of the Poincare group and localized in semi-infinite strings extending to spacelike infinity. Among these are fields that generate the irreducible representations of mass zero and infinite spin that are known to be incompatible with point-like localized fields. For the massive representation and the massless representations of finite helicity, all string-localized free fields can be written as an integral, along the string, of point-localized tensor or spinor fields. As a special case we discuss the string-localized vector fields associated with the point-like electromagnetic field and their relation to the axial gauge condition in the usual setting. (author)

The management of localized and locally advanced prostate cancer - 1995

International Nuclear Information System (INIS)

Forman, Jeffrey D.

1995-01-01

Purpose/Objectives: The intent of this course is to review the issues involved in the management of non-metastatic adenocarcinoma of the prostate. - The value of pre-treatment prognostic factors including stage, grade and PSA value will be presented, and their value in determining therapeutic strategies will be discussed. - Controversies involving the simulation process and treatment design will be presented. The value of CT scanning, Beams-Eye View, 3-D planning, intravesicle, intraurethral and rectal contrast will be presented. The significance of prostate and patient movement and strategies for dealing with them will be presented. - The management of low stage, low to intermediate grade prostate cancer will be discussed. The dose, volume and timing of irradiation will be discussed as will the role of neo-adjuvant hormonal therapy, neutron irradiation and brachy therapy. The current status of radical prostatectomy and cryotherapy will be summarized. - Treatment of locally advanced, poorly differentiated prostate cancer will be presented including a discussion of neo-adjuvant and adjuvant hormones, dose-escalation and neutron irradiation. - Strategies for post-radiation failures will be presented including data on cryotherapy, salvage prostatectomy and hormonal therapy (immediate, delayed and/or intermittent). New areas for investigation will be reviewed. - The management of patients post prostatectomy will be reviewed. Data on adjuvant radiation and therapeutic radiation for biochemical or clinically relapsed patients will be presented. This course hopes to present a realistic and pragmatic overview for treating patients with non-metastatic prostatic cancer

Multi-objective decisions in land-use planning involving chemical sites

DEFF Research Database (Denmark)

Rasmussen, B.; Bertelsen, I.; Burchard, V.

1999-01-01

A methodology for land-use planning involving chemical sites has been developed for making decisions in local and regional administrations. The methodology structures the planning process in seven steps, where one can loop through the steps several times.Essential parts of the methodology...... are the specification of objectives and the development of alternatives where the objectives sets the frame in which the alternatives are assessed and compared. The list of objectives includes the following items: safetyand accidents, public distortion and health, environmental impact, cultural and natural heritage...

An Urologic Face of Chronic Lymphocytic Leukemia:Sequential Prostatic and Penis Localization

Directory of Open Access Journals (Sweden)

Giovanni D'Arena

2013-01-01

Full Text Available We report a patient with chronic lymphocytic leukemia (CLL in whom a leukemic involvement of prostate and penis occurred in the advanced phase of his disease. Obstructive urinary symptoms were indicative of prostatic CLL infiltration, followed by the occurrence of an ulcerative lesion on the glans. Histologic examination confirmed  the  neoplastic B-cell infiltration. Both localizations responded to conventional treatments. A review of the literature confirms that leukemic involvement of the genito-urinary system is   uncommon in CLL patients. However, such an involvement should be considered in CLL patients with urologic symptoms and a long history of the disease.

Strategies for Local Low-Carbon Development

Energy Technology Data Exchange (ETDEWEB)

Zhou, Nan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Price, Lynn [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Fridley, David [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ohshita, Stephanie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Khanna, Nina [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Min, Hu [Energy Foundation China, Beijing (China); Xiulian, Hu [Energy Research Inst., Beijing (China)

2012-11-14

Cities around the world are implementing policies and programs with the goal to reduce greenhouse gas emissions, as well as save energy, reduce costs, and protect the local, regional, and global environment. In China, low-carbon development is a key element of the 12th Five Year Plan. Pilot low-carbon development zones have been initiated in five provinces and eight cities and many other locations around China also want to pursue a low-carbon development pathway. This booklet provides information for government officials, policy makers, program designers and implementers, provincial and city planners, and others who want an overview of the key options available for low-carbon development at local level. These Strategies for Local Low-Carbon Development draw from successful experiences from around the world. Information is provided for low-carbon actions that can be taken in the sectors of (1) Industry, (2) Buildings and Appliances, (3) Electric Power, (4) Consumption and Waste Management, (5) Transportation and Urban Form, and (6) Agriculture and Forestry. A description of each policy is provided along with information on the stakeholders involved in implementation, the conditions for successful implementation, the expected energy and carbon savings, and the policy cost-effectiveness. Case studies show how each policy has been implemented somewhere around the world. While there are many low-carbon options available for local implementation, this booklet aims to provide guidance on those that have been most successful, that have the largest impact, and that are cost-effective in order to support low-carbon development efforts in Chinese cities.

Governance and Youth Participation in local policy making

DEFF Research Database (Denmark)

Eklund Karlsson, Leena; Haaber Pettersen, Charlotte Louise; Aro, Arja R.

2016-01-01

research strategy was applied to examine these two case studies. Data was collected under the REPOPA Project (Research into Policy to enhance Physical Activity) though semi-structures interviews (N=11), analysed through content analysis and supported by analysis of 123 background documents. Results: Youth...... was involved in policy making only through adult representation. These adult stakeholders became part of participatory governance in developing the healthy public policies in both Odense and Esbjerg municipalities. Conclusion: Youth participation in local HEPA policy making in Esbjerg and Odense did not meet...... the Danish principle of participatory policy process and good health system governance. Main messages: Mechanisms to facilitate youth participation in policy making in the study communities were lacking. The Danish goal of improved participatory policy making at the local level was not met....

Patterns of Failure and Local Control After Intraoperative Electron Boost Radiotherapy to the Presacral Space in Combination with Total Mesorectal Excision in Patients with Locally Advanced Rectal Cancer

International Nuclear Information System (INIS)

Roeder, Falk; Treiber, Martina; Oertel, Susanne; Dinkel, Julien; Timke, Carmen; Funk, Angela; Garcia-Huttenlocher, Helena; Bischof, Marc; Weitz, Juergen; Harms, Wolfgang; Hensley, Frank W.; Buchler, Markus W.; Debus, Juergen; Krempien, Robert

2007-01-01

Purpose: To evaluate local control and patterns of failure in patients treated with intraoperative electron beam radiotherapy (IOERT) after total mesorectal excision (TME), to appraise the effectiveness of intraoperative target definition. Methods and Materials: We analyzed the outcome of 243 patients with rectal cancer treated with IOERT (median dose, 10 Gy) after TME. Eighty-eight patients received neoadjuvant and 122 patients adjuvant external beam radiotherapy (EBRT) (median dose, 41.4 Gy), and in 88% simultaneous chemotherapy was applied. Median follow-up was 59 months. Results: Local failure was observed in 17 patients (7%), resulting in a 5-year local control rate of 92%. Only complete resection and absence of nodal involvement correlated positively with local control. Considering IOERT fields, seven infield recurrences were seen in the presacral space, resulting in a 5-year local control rate of 97%. The remaining local relapses were located as follows: retrovesical/retroprostatic (5), anastomotic site (2), promontorium (1), ileocecal (1), and perineal (1). Conclusion: Intraoperative electron beam radiotherapy as part of a multimodal treatment approach including TME is a highly effective regimen to prevent local failure. The presacral space remains the site of highest risk for local failure, but IOERT can decrease the percentage of relapses in this area

Computing wave functions in multichannel collisions with non-local potentials using the R-matrix method

Science.gov (United States)

Bonitati, Joey; Slimmer, Ben; Li, Weichuan; Potel, Gregory; Nunes, Filomena

2017-09-01

The calculable form of the R-matrix method has been previously shown to be a useful tool in approximately solving the Schrodinger equation in nuclear scattering problems. We use this technique combined with the Gauss quadrature for the Lagrange-mesh method to efficiently solve for the wave functions of projectile nuclei in low energy collisions (1-100 MeV) involving an arbitrary number of channels. We include the local Woods-Saxon potential, the non-local potential of Perey and Buck, a Coulomb potential, and a coupling potential to computationally solve for the wave function of two nuclei at short distances. Object oriented programming is used to increase modularity, and parallel programming techniques are introduced to reduce computation time. We conclude that the R-matrix method is an effective method to predict the wave functions of nuclei in scattering problems involving both multiple channels and non-local potentials. Michigan State University iCER ACRES REU.

The role of local governments in traditional market revitalization

Science.gov (United States)

Prastyawan, A.; Isbandono, P.

2018-01-01

This paper presents the discussion the role of local government in traditional market revitalization. It is obvious that traditional market contributes economically into a certain region. However, the existence of the traditional market is decreasing since there are modern markets that are fully facilitated by the government. In order to increase the economic standard of the traders, the government and the legislative revitalized the improper traditional market, without the participation of the society and the stakeholders. Government’s intention to revitalize the market is to increase local revenue. While the Legislative Council considered politically motivated by profit, rent-seeking. Restrictions on the aspirations of the traders in the revitalization cause resistance to the government. The traders wished to be recognized as part of the stakeholder. In the future, the market revitalization activities should involve the traders as the main actors who have received services from the government. Government as policy makers should consider as it partners in developing business traders and increase local revenues.

Papaya Development Model As A Competitive Local Superior Commodity

Directory of Open Access Journals (Sweden)

Reny Sukmawani

2014-12-01

Full Text Available The aim of this research is to study the comparative advantage and papaya competitive and to design its development model by using the approach of local base agriculture development. This research uses survey method. The resulting research shows that papaya is a base commodity that has comparative advantage and competitive. The development papaya in the district of Sukabumi is quite good bases on eight superior creations. But in order to be the main sector in economic development and has a competition, the development of papaya must concern to its influence factors. In supporting papaya development as a competitive local superior commodity, it needs to be done some efforts are as follows: (1 increase a skillful worker; (2 improve business management; (3 increase papaya productivity by using technology and study papaya planted technology in specific local superior commodity; (4 develop the involvement of the business relation; (5 provide market information and information technology network; and (6 improve infrastructures.

Inference for local autocorrelations in locally stationary models.

Science.gov (United States)

Zhao, Zhibiao

2015-04-01

For non-stationary processes, the time-varying correlation structure provides useful insights into the underlying model dynamics. We study estimation and inferences for local autocorrelation process in locally stationary time series. Our constructed simultaneous confidence band can be used to address important hypothesis testing problems, such as whether the local autocorrelation process is indeed time-varying and whether the local autocorrelation is zero. In particular, our result provides an important generalization of the R function acf() to locally stationary Gaussian processes. Simulation studies and two empirical applications are developed. For the global temperature series, we find that the local autocorrelations are time-varying and have a "V" shape during 1910-1960. For the S&P 500 index, we conclude that the returns satisfy the efficient-market hypothesis whereas the magnitudes of returns show significant local autocorrelations.

Evaluation of preoperative radiation combined with chemotherapy for prevention of local recurrence of rectal cancer

International Nuclear Information System (INIS)

Sarashina, Hiromi; Inoue, Ikuo; Saitoh, Norio

1990-01-01

A retrospective study of 44 patients with rectal cancer who received preoperative radiation (42.6 Gy) combined with chemotherapy and 37 who received resection alone (control group) was undertaken to evaluate the effect of preoperative radiation therapy on local recurrence of rectal cancer. The rate of local recurrence in the radiation group was reduced to 4.5% compared with that in the controls (18.9%). From a pathological point of view, factors that have a close association with recurrence, such as depth of invasion, ew (defined as the distance between the external surgical surface and the deepest site of invasion) and lymph nodal involvement, have been successfully changed after radiation therapy. It was also evident that the rate of recurrence in irradiated patients, depth of invasion of a 2 (defined as the invasion of cancer far beyond the muscle layer but without involvement of other organs) or ew less than 2 mm was significantly lower than in patients with the same pathological conditions in whom radiation was not used. However, especially in patients with remote lymph node metastasis, there was no difference in local recurrence rate between the two groups. From these findings, it was concluded that a careful follow up is necessary for patients with remote lymph node involvement even after radiation therapy. (author)

Tracheal and Crico-Tracheal Resection and Anastomosis for Malignancies Involving the Thyroid Gland and the Airway.

Science.gov (United States)

Piazza, Cesare; Del Bon, Francesca; Barbieri, Diego; Grazioli, Paola; Paderno, Alberto; Perotti, Pietro; Lombardi, Davide; Peretti, Giorgio; Nicolai, Piero

2016-02-01

To evaluate outcomes in different malignancies involving the thyroid and infiltrating the airway submitted to tracheal (TRA) or crico-tracheal resection and anastomosis (CTRA). Retrospective charts review of 27 patients affected by thyroid malignancies involving the airway treated by TRA/CTRA in a single academic institution. Kaplan-Meier curves were used to evaluate the overall (OS) and disease-specific (DSS) survivals and local (LC) and loco-regional control (LRC). Impact on survival of age, comorbidities, previous radiotherapy, types of TRA/CTRA, Shin's stage (II, III, IV), grading (well vs poorly differentiated), and length of airway resected was calculated by the log-rank test. Overall survival and DSS at 3 and 5 years were 82.3% and 71.6%, respectively. Local control and LRC in the entire group were 82.3% at 3 and 5 years. Crico-tracheal resection and anastomosis involving the cricoid arch and plate (type C) and tumor differentiation significantly affected OS and DSS (both P < .001). Type C CTRA and tumor differentiation significantly impacted on LC (P = .002 and P = .009, respectively). Grading and extension of CTRA to the cricoid plate are the most important factors for oncologic outcomes in thyroid malignancies infiltrating the airway. Except for poorly differentiated tumors, TRA/CTRA allows adequate LC even in advanced stage lesions involving the crico-tracheal junction. © The Author(s) 2015.

Local Stereo Matching Using Adaptive Local Segmentation

NARCIS (Netherlands)

Damjanovic, S.; van der Heijden, Ferdinand; Spreeuwers, Lieuwe Jan

We propose a new dense local stereo matching framework for gray-level images based on an adaptive local segmentation using a dynamic threshold. We define a new validity domain of the fronto-parallel assumption based on the local intensity variations in the 4-neighborhood of the matching pixel. The

Aggressive Angiomyxoma Involving Penis and Urethra - A Case Report.

Science.gov (United States)

Damodaran, Shivashankar; Gengan, Devakannan; Walling, Sashi T

2017-07-01

Aggressive angiomyxoma is a rare benign mesenchymal stromal tumour, characterized by locally infiltrative nature and a tendency for recurrence. Only a few cases of penile involvement have been reported in the literature so far. We report a case of aggressive penile angiomyxoma in a sixty-two-year-old obese, diabetic male patient. He presented with obstructive lower urinary tract symptoms (LUTS) and diffuse enlargement of the penis and scrotum. He was managed with excision, reduction scrotoplasty, internal urethrotomy, followed by Leuprolide therapy for prevention of recurrence. He is on follow up for 20 months without recurrence and obstructive symptoms.

Piloting a local dental network across Hampshire and Isle of Wight Primary Care Trusts.

Science.gov (United States)

John, J H; Easterby-Smith, V; Percival, K R

2014-09-01

To pilot a local dental network (LDN) within the Hampshire and Isle of Wight region. An LDN Coordinating Group was set up, which was chaired by the local consultant in dental public health and included representatives from dental commissioning and performance management teams, dental practice advisory team, finance, Oxford and Wessex Dental Deanery and the Hampshire and Isle of Wight Local Dental Committee. The LDN successfully led the organisation of a leadership training course for local dentists, and produced recommendations for local oral surgery and orthodontics care pathways. Key to the success was the collaboration achieved between the commissioners, local postgraduate dental deanery and local dental committee. There were challenges associated with involving non-salaried dental practitioners without a source of funding, and with communicating with the wider dental community. The new Wessex LDN needs to be adequately resourced and integrated into the local commissioning structure, as well as the wider health system, to function effectively. Most importantly, the LDN needs local dental professionals to embrace the opportunities for leadership and use their skills to inform and influence local dental commissioning for the benefit of the local population.

Phospholipases Dα and δ are involved in local and systemic wound responses of cotton (G. hirsutum

Directory of Open Access Journals (Sweden)

Angeliki Bourtsala

2017-03-01

Full Text Available Phospholipases D (PLDs catabolize structural phospholipids to produce phosphatidic acid (PtdOH, a lipid playing central role in signalling pathways in animal, yeast and plant cells. In animal cells two PLD genes have been studied while in model plant Arabidopsis twelve genes exist, classified in six classes (α-ζ. This underlines the role of these enzymes in plant responses to environmental stresses. However, information concerning the PLD involvement in the widely cultivated and economically important cotton plant responses is very limited. The aim of this report was to study the activity of conventional cotton PLD and its participation in plant responses to mechanical wounding, which resembles both biotic and abiotic stresses. PLDα activity was identified and further characterized by transphosphatidylation reaction. Upon wounding, cotton leaf responses consist of an acute in vitro increase of PLDα activity in both wounded and systemic tissue. However, determination of the in vivo PtdOH levels under the same wounding conditions revealed a rapid PtdOH formation only in wounded leaves and a late response of a PtdOH increase in both tissues. Εxpression analysis of PLDα and PLDδ isoforms showed mRNA accumulation of both isoforms in the wounded tissue, but only PLDδ exerts a high and sustainable expression in systemic leaves, indicating that this isoform is mainly responsible for the systemic wound-induced PtdOH production. Therefore, our data suggest that PLDα and PLDδ isoforms are involved in different steps in cotton wound signalling.

On localization and void coalescence as a precursor to ductile fracture.

Science.gov (United States)

Tekoğlu, C; Hutchinson, J W; Pardoen, T

2015-03-28

Two modes of plastic flow localization commonly occur in the ductile fracture of structural metals undergoing damage and failure by the mechanism involving void nucleation, growth and coalescence. The first mode consists of a macroscopic localization, usually linked to the softening effect of void nucleation and growth, in either a normal band or a shear band where the thickness of the band is comparable to void spacing. The second mode is coalescence with plastic strain localizing to the ligaments between voids by an internal necking process. The ductility of a material is tied to the strain at macroscopic localization, as this marks the limit of uniform straining at the macroscopic scale. The question addressed is whether macroscopic localization occurs prior to void coalescence or whether the two occur simultaneously. The relation between these two modes of localization is studied quantitatively in this paper using a three-dimensional elastic-plastic computational model representing a doubly periodic array of voids within a band confined between two semi-infinite outer blocks of the same material but without voids. At sufficiently high stress triaxiality, a clear separation exists between the two modes of localization. At lower stress triaxialities, the model predicts that the onset of macroscopic localization and coalescence occur simultaneously. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

An Evaluation of The Effects of Local Mix Design on the ...

African Journals Online (AJOL)

This is a report on an evaluation of the effect of local mix design of concrete on its compressive strength. In order to accomplish this research work, field survey was first undertaken with a well-structured questionnaire. This questionnaire was administered to the respondents who are directly involved in concrete production.

Contemporaneous Peer Effects, Career Age and the Industry Involvement of Academics in Biotechnology

DEFF Research Database (Denmark)

Aschhoff, Birgit; Grimpe, Christoph

2014-01-01

This study explores the role of contemporaneous peer effects in driving an academic's involvement with industry. Specifically, we examine the influence of workplace peers and personal collaborators and how these effects are moderated by the career age of the scientist. Moreover, we look...... that a scientist's involvement increases with the industry orientation of the scientist's co-authors (“personal peer effect”), irrespective of the scientist's age. In case both types of social influence are incongruent, younger scientists will revert to localized norms while more experienced scientists will orient...... at situations in which both types of social influence are incongruent and the academic is faced with “dissonance”. Based on survey data of 355 German academics in the field of biotechnology and publication data from the Science Citation Index Expanded (SCIE), we find that the scientist's involvement...

Evidence for the involvement of MC4 receptors in the central mechanisms of opioid antinociception

NARCIS (Netherlands)

Starowicz, Katarzyna

2005-01-01

The data described in this thesis extend general knowledge of the involvement of the MC4 receptor in mechanisms of analgesia. The following aspects outlined below constitute novel information. Firstly, the MC4R localization in the DRG is demonstrated. The MC4 receptor was assumed to exist

Universities, local partnerships and the promotion of youth entrepreneurship

Science.gov (United States)

Bezerra, Éder D.; Borges, Cândido; Andreassi, Tales

2017-10-01

Youth entrepreneurship has gained prominence in recent years, but there are few studies which investigate the characteristics of companies created by students in the university environment (also known as "student spin-off companies") or the "ecosystem" in which these companies are incubated and "hatched". In parallel, there is a call for more research investigating the role universities play in the local development of these companies. In practice, there is an increasing demand for universities to interact with and engage in the local context beyond their institutional "walls". Therefore, the purpose of this article is to understand how universities bring together local partners in support of young entrepreneurs. To this end, the authors conducted a multiple case study which identified the processes, characteristics and actors involved in the formation of these networks. As a theoretical contribution to the development of local entrepreneurship, this article analyses student spin-off companies incubated in universities - a type of business as well as a context still little explored in the literature. On a practical level, it offers insights into potential strategies for improving policies to support youth and student entrepreneurship.

Professionals without a profession? Redesigning case management in Dutch local welfare agencies

NARCIS (Netherlands)

van Berkel, H.H.A.; van der Aa, P.; van Gestel, N.

2010-01-01

This article explores the new roles of frontline workers in Dutch local welfare agencies against the background of recent active welfare state reforms, with a specific focus on frontline workers involved in activating social assistance recipients. The results presented in the article come from case

Integrated modeling and characterization of local crack chemistry

International Nuclear Information System (INIS)

Savchik, J.A.; Burke, M.S.

1996-01-01

The MULTEQ computer program has become an industry wide tool which can be used to calculate the chemical composition in a flow occluded region as the solution within concentrates due to a local boiling process. These results can be used to assess corrosion concerns in plant equipment such as steam generators. Corrosion modeling attempts to quantify corrosion assessments by accounting for the mass transport processes involved in the corrosion mechanism. MULTEQ has played an ever increasing role in defining the local chemistry for such corrosion models. This paper will outline how the integration of corrosion modeling with the analysis of corrosion films and deposits can lead to the development of a useful modeling tool, wherein MULTEQ is interactively linked to a diffusion and migration transport process. This would provide a capability to make detailed inferences of the local crack chemistry based on the analyses of the local corrosion films and deposits inside a crack and thus provide guidance for chemical fixes to avoid cracking. This methodology is demonstrated for a simple example of a cracked tube. This application points out the utility of coupling MULTEQ with a mass transport process and the feasibility of an option in a future version of MULTEQ that would permit relating film and deposit analyses to the local chemical environment. This would increase the amount of information obtained from removed tube analyses and laboratory testing that can contribute to an overall program for mitigating tubing and crevice corrosion

Integrated modeling and characterization of local crack chemistry

International Nuclear Information System (INIS)

Savchik, J.A.; Burke, M.S.

1995-01-01

The MULTEQ computer program has become an industry wide tool which can be used to calculate the chemical composition in a flow occluded region as the solution within concentrates due to a local boiling process. These results can be used to assess corrosion concerns in plant equipment such as steam generators. Corrosion modeling attempts to quantify corrosion assessments by accounting for the mass transport processes involved in the corrosion mechanism. MULTEQ has played an ever increasing role in defining the local chemistry for such corrosion models. This paper will outline how the integration of corrosion modeling with the analysis of corrosion films and deposits can lead to the development of a useful modeling tool, wherein MULTEQ is interactively linked to a diffusion and migration transport process. This would provide a capability to make detailed inferences of the local crack chemistry based on the analyses of the local corrosion films and deposits inside a crack and thus provide guidance for chemical fixes to avoid cracking. This methodology is demonstrated for a simple example of a cracked tube. This application points out the utility of coupling MULTEQ with a mass transport process and the feasibility of an option in a future version of MULTEQ that would permit relating film and deposit analyses to the local chemical environment. This would increase the amount of information obtained from removed tube analyses and laboratory testing that can contribute to an overall program for mitigating tubing and crevice corrosion

Vision based persistent localization of a humanoid robot for locomotion tasks

Directory of Open Access Journals (Sweden)

Martínez Pablo A.

2016-09-01

Full Text Available Typical monocular localization schemes involve a search for matches between reprojected 3D world points and 2D image features in order to estimate the absolute scale transformation between the camera and the world. Successfully calculating such transformation implies the existence of a good number of 3D points uniformly distributed as reprojected pixels around the image plane. This paper presents a method to control the march of a humanoid robot towards directions that are favorable for visual based localization. To this end, orthogonal diagonalization is performed on the covariance matrices of both sets of 3D world points and their 2D image reprojections. Experiments with the NAO humanoid platform show that our method provides persistence of localization, as the robot tends to walk towards directions that are desirable for successful localization. Additional tests demonstrate how the proposed approach can be incorporated into a control scheme that considers reaching a target position.

Arabidopsis phospholipase Dδ is involved in basal defense and nonhost resistance to powdery mildew fungi

DEFF Research Database (Denmark)

Pinosa, Francesco; Buhot, Nathalie; Kwaaitaal, Mark Adrianus Cornelis J

2013-01-01

resistance against Bgh, and chemical inhibition of PLDs in plants mutated in PLDδ indicated that this isoform alone is involved in Bgh resistance. In addition, we confirmed the involvement of PLDδ in penetration resistance against another nonadapted pea powdery mildew fungus, Erysiphe pisi. A green...... fluorescent protein fusion of PLDδ localized to the plasma membrane at the Bgh attack site, where it surrounded the cell wall reinforcement. Furthermore, in the pldδ mutant, transcriptional up-regulation of early microbe-associated molecular pattern response genes was delayed after chitin stimulation...

The specific localization of advanced glycation end-products (AGEs) in rat pancreatic islets.

Science.gov (United States)

Morioka, Yuta; Teshigawara, Kiyoshi; Tomono, Yasuko; Wang, Dengli; Izushi, Yasuhisa; Wake, Hidenori; Liu, Keyue; Takahashi, Hideo Kohka; Mori, Shuji; Nishibori, Masahiro

2017-08-01

Advanced glycation end-products (AGEs) are produced by non-enzymatic glycation between protein and reducing sugar such as glucose. Although glyceraldehyde-derived AGEs (Glycer-AGEs), one of the AGEs subspecies, have been reported to be involved in the pathogenesis of various age-relating diseases such as diabetes mellitus or arteriosclerosis, little is known about the pathological and physiological mechanism of AGEs in vivo. In present study, we produced 4 kinds of polyclonal antibodies against AGEs subspecies and investigated the localization of AGEs-modified proteins in rat peripheral tissues, making use of these antibodies. We found that Glycer-AGEs and methylglyoxal-derived AGEs (MGO-AGEs) were present in pancreatic islets of healthy rats, distinguished clearly into the pancreatic α and β cells, respectively. Although streptozotocin-induced diabetic rats suffered from remarkable impairment of pancreatic islets, the localization and deposit levels of the Glycer- and MGO-AGEs were not altered in the remaining α and β cells. Remarkably, the MGO-AGEs in pancreatic β cells were localized into the insulin-secretory granules. These results suggest that the cell-specific localization of AGEs-modified proteins are presence generally in healthy peripheral tissues, involved in physiological intracellular roles, such as a post-translational modulator contributing to the secretory and/or maturational functions of insulin. Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Localization of musicogenic epilepsy to Heschl's gyrus and superior temporal plane: case report.

Science.gov (United States)

Nagahama, Yasunori; Kovach, Christopher K; Ciliberto, Michael; Joshi, Charuta; Rhone, Ariane E; Vesole, Adam; Gander, Phillip E; Nourski, Kirill V; Oya, Hiroyuki; Howard, Matthew A; Kawasaki, Hiroto; Dlouhy, Brian J

2017-09-15

Musicogenic epilepsy (ME) is an extremely rare form of the disorder that is provoked by listening to or playing music, and it has been localized to the temporal lobe. The number of reported cases of ME in which intracranial electroencephalography (iEEG) has been used for seizure focus localization is extremely small, especially with coverage of the superior temporal plane (STP) and specifically, Heschl's gyrus (HG). The authors describe the case of a 17-year-old boy with a history of medically intractable ME who underwent iEEG monitoring that involved significant frontotemporal coverage as well as coverage of the STP with an HG depth electrode anteriorly and a planum temporale depth electrode posteriorly. Five seizures occurred during the monitoring period, and a seizure onset zone was localized to HG and the STP. The patient subsequently underwent right temporal neocortical resection, involving the STP and including HG, with preservation of the mesial temporal structures. The patient remains seizure free 1 year postoperatively. To the authors' knowledge, this is the first reported case of ME in which the seizure focus has been localized to HG and the STP with iEEG monitoring. The authors review the literature on iEEG findings in ME, explain their approach to HG depth electrode placement, and discuss the utility of STP depth electrodes in temporal lobe epilepsy.

Spatial Distribution Of Local Markets In Ife North Local Government Area

Directory of Open Access Journals (Sweden)

OMOTOYE-OMISORE Oyelola

2015-08-01

Full Text Available Researches have been carried out in the past by several authors concerning agricultural marketing without the use of geospatial techniques. This research therefore is meant to show the efficacy of Geographical Information System GIS in local market distribution. The role of market place as a man-made feature where goods and services are exchanged for the purpose of satisfying human needs cannot be overemphasized especially in the general development of villages and towns. This study shows the effectiveness of GIS without the use of metrics method to determine the agricultural market locations and closeness of the markets in Ife North Local Government area. Different kinds of people bring their goods from far and near villages for sale and sustainability in this research both primary and secondary data were collected. Primary data includes the use of Global Positioning System GPS receiver to collect coordinate points of the existing markets. It also involves verbal interview with market women. While secondary data were sourced from administrative maps and satellite images of the area of study it was geo-referenced and digitized. Arc Map was used to run average nearest neighbor analysis. Base on the analysis performed the major constraint facing the market people is poor road network which affect majority of the farmers in transporting their goods from remote villages as indicated in this study. As a result new markets sites were proposed with the use of geospatial techniques for easy accessibility.

Frataxin Is Localized to Both the Chloroplast and Mitochondrion and Is Involved in Chloroplast Fe-S Protein Function in Arabidopsis.

Directory of Open Access Journals (Sweden)

Valeria R Turowski

Full Text Available Frataxin plays a key role in eukaryotic cellular iron metabolism, particularly in mitochondrial heme and iron-sulfur (Fe-S cluster biosynthesis. However, its precise role has yet to be elucidated. In this work, we studied the subcellular localization of Arabidopsis frataxin, AtFH, using confocal microscopy, and found a novel dual localization for this protein. We demonstrate that plant frataxin is targeted to both the mitochondria and the chloroplast, where it may play a role in Fe-S cluster metabolism as suggested by functional studies on nitrite reductase (NIR and ferredoxin (Fd, two Fe-S containing chloroplast proteins, in AtFH deficient plants. Our results indicate that frataxin deficiency alters the normal functioning of chloroplasts by affecting the levels of Fe, chlorophyll, and the photosynthetic electron transport chain in this organelle.

A devolved model for public involvement in the field of mental health research: case study learning.

Science.gov (United States)

Moule, Pam; Davies, Rosie

2016-12-01

Patient and public involvement in all aspects of research is espoused and there is a continued interest in understanding its wider impact. Existing investigations have identified both beneficial outcomes and remaining issues. This paper presents the impact of public involvement in one case study led by a mental health charity conducted as part of a larger research project. The case study used a devolved model of working, contracting with service user-led organizations to maximize the benefits of local knowledge on the implementation of personalized budgets, support recruitment and local user-led organizations. To understand the processes and impact of public involvement in a devolved model of working with user-led organizations. Multiple data collection methods were employed throughout 2012. These included interviews with the researchers (n = 10) and research partners (n = 5), observation of two case study meetings and the review of key case study documentation. Analysis was conducted in NVivo10 using a coding framework developed following a literature review. Five key themes emerged from the data; Devolved model, Nature of involvement, Enabling factors, Implementation challenges and Impact. While there were some challenges of implementing the devolved model it is clear that our findings add to the growing understanding of the positive benefits research partners can bring to complex research. A devolved model can support the involvement of user-led organizations in research if there is a clear understanding of the underpinning philosophy and support mechanisms are in place. © 2015 The Authors. Health Expectations Published by John Wiley & Sons Ltd.

Introduction of new technologies and decision making processes: a framework to adapt a Local Health Technology Decision Support Program for other local settings.

Science.gov (United States)

Poulin, Paule; Austen, Lea; Scott, Catherine M; Poulin, Michelle; Gall, Nadine; Seidel, Judy; Lafrenière, René

2013-01-01

Introducing new health technologies, including medical devices, into a local setting in a safe, effective, and transparent manner is a complex process, involving many disciplines and players within an organization. Decision making should be systematic, consistent, and transparent. It should involve translating and integrating scientific evidence, such as health technology assessment (HTA) reports, with context-sensitive evidence to develop recommendations on whether and under what conditions a new technology will be introduced. However, the development of a program to support such decision making can require considerable time and resources. An alternative is to adapt a preexisting program to the new setting. We describe a framework for adapting the Local HTA Decision Support Program, originally developed by the Department of Surgery and Surgical Services (Calgary, AB, Canada), for use by other departments. The framework consists of six steps: 1) development of a program review and adaptation manual, 2) education and readiness assessment of interested departments, 3) evaluation of the program by individual departments, 4) joint evaluation via retreats, 5) synthesis of feedback and program revision, and 6) evaluation of the adaptation process. Nine departments revised the Local HTA Decision Support Program and expressed strong satisfaction with the adaptation process. Key elements for success were identified. Adaptation of a preexisting program may reduce duplication of effort, save resources, raise the health care providers' awareness of HTA, and foster constructive stakeholder engagement, which enhances the legitimacy of evidence-informed recommendations for introducing new health technologies. We encourage others to use this framework for program adaptation and to report their experiences.

77 FR 42465 - Special Local Regulations, Cruce a Nado Internacional, Ponce Harbor; Ponce, PR

Science.gov (United States)

2012-07-19

... effect on the human environment. This proposed rule involves special local regulations issued in.... Dated: June 7, 2012. D.W. Pearson, Captain, U.S. Coast Guard, Captain of the Port San Juan. [FR Doc...

AtTZF gene family localizes to cytoplasmic foci

OpenAIRE

Pomeranz, Marcelo; Lin, Pei-Chi; Finer, John; Jang, Jyan-Chyun

2010-01-01

In eukaryotes, mRNA turnover and translational repression represent important regulatory steps in gene expression. Curiously, when under cellular stresses, factors involved in these processes aggregate into cytoplasmic foci known as Processing bodies (P-bodies) and Stress Granules (SGs). In animals, CCCH Tandem Zinc Finger (TZF) proteins play important roles in mRNA decay within P-bodies. TTP, a P-body localized mammalian TZF, can bind to the 3'UTRs of mRNAs containing AU-rich elements (AREs)...

Exploring the Local Elastic Properties of Bilayer Membranes Using Molecular Dynamics Simulations

DEFF Research Database (Denmark)

Pieffet, Gilles; Botero, Alonso; Peters, Günther H.J.

2014-01-01

Membrane mechanical elastic properties regulate a variety of cellular processes involving local membrane deformation, such as ion channel function and vesicle fusion. In this work, we used molecular dynamics simulations to estimate the local elastic properties of a membrane. For this, we calculated...... the stretching process in molecular detail, allowing us to fit this profile to a previously proposed continuum elastic model. Through this approach, we calculated an effective membrane spring constant of 42 kJ-2.mol-1, which is in good agreement with the PMF calculation. Furthermore, the solvation energy we...

Towards a local learning (innovation) model of solar photovoltaic deployment

International Nuclear Information System (INIS)

Shum, Kwok L.; Watanabe, Chihiro

2008-01-01

It is by now familiar that in the deployment of solar photovoltaic (PV) systems, the cost dynamics of major system component like solar cell/module is subjected to experience curve effects driven by production learning and research and development at the supplier side. What is less clear, however, is the economics of system integration or system deployment that takes place locally close to the user, involving other market players, in the downstream solar PV value chain. Experts have agreed that suppliers of solar PV system must customize their flexible characteristics to address local unique users' and applications requirements and compete on price/performance basis. A lack of understanding of the drivers of the economics of system customization therefore is a deficiency in our understanding of the overall economics of this renewable energy technology option. We studied the non-module BOS cost for grid-connected small PV system using the experience curve framework. Preliminary analysis of PV statistics of the US from IEA seems to suggest that learning in one application type is taking place with respect to the cumulative installation among all types of grid-connected small PV projects. The effectiveness of this learning is also improving over time. A novel aspect is the interpretation of such experience curve effect or learning pattern. We draw upon the notion of product platform in the industrial management literature and consider different types of local small-scale grid-tied PV customization projects as adapting a standard platform to different idiosyncratic and local application requirements. Economics of system customization, which is user-oriented, involves then a refined notion of inter-projects learning, rather than volume-driven learning by doing. We formalized such inter-projects learning as a dynamic economy of scope, which can potentially be leveraged to manage the local and downstream aspect of PV deployment. This dynamic economy may serve as a focus

Local food:

DEFF Research Database (Denmark)

Sundbo, Donna Isabella Caroline

2013-01-01

are identified and then categorised according to whether they pertain to the food product itself or the production methods and facilities and whether they describe physical or social properties of local food. From this a model with four categories is developed. It is found that properties of the product are more......Recently there has been more focus on food in general and local food in particular. But what is local food? And what are the perceptions of this concept according to theory and to providers and consumers of local food? This article first summarises and compares three different theoretical...... perspectives on local food, namely experience economy, local food systems and what is termed pro-industrialism. These have differing and sometimes opposite conceptualisations and aims for the concept of local food. Using the perspective of experience economy as theoretical background, the concept of local food...

Local and Regional Spread of Primary Conjunctival Squamous Cell Carcinoma.

Science.gov (United States)

Desai, Shilpa J; Pruzan, Noelle L; Geske, Michael J; Jeng, Bennie H; Bloomer, Michele M; Vagefi, M Reza

2016-04-06

Two cases of biopsy-proven conjunctival squamous cell carcinoma (SCC) that developed local and regional spread are described. The cases involved a 65-year-old woman and a 79-year-old man who were initially treated at outside institutions for SCC of the conjunctiva. The patients did not have a history of immune compromise. The female patient presented with direct extension into the lacrimal gland but deferred recommended exenteration. Despite eventual exenteration, she developed metastasis to a neck node 6 months later, which was treated with radiotherapy. The male patient presented with local recurrence and a parotid node metastasis treated with exenteration, parotidectomy, selective neck dissection, and postoperative radiotherapy. Review of the outside pathology of both cases revealed positive tumor margins at the time of original resection. Local control of conjunctival SCC is of critical importance to reduce the risk of orbital extension and regional spread.

Build Locally, Link Globally: The Social Forum Process in Italy

Directory of Open Access Journals (Sweden)

Donatella della Porta

2015-08-01

Full Text Available Considered an innovation because of its capacity to develop transnational processes, the World Social Forum however also has strong local roots as well as effects on organizational models and collective identities at the domestic level. Focusing on the Italian case, this article shows how local social forums, as arenas for exchanges of ideas, played a cognitive role in the import, but also the translation of new ideas, as well as helping the emergence of dense network structures and tolerant identities. The first section of the article examines how local social forums contributed to innovation in the organizational formulas of the Global Justice Movement—considering both structure (organizations and process (methodologies aspects—through the development of different, more participatory conceptions of internal decision making. It then addresses the innovations in the definition of collective identities, stressing the linkages of local struggles and global framing as well as the development of a cross-issue discourse around an anti-neoliberal frame. The final section will discuss the contribution of local social forums to contemporary social movements, stressing the role of these new arenas for the cross-fertilization among different movement families and spreading a method of working together that becomes part of the repertoire of action of local social movement organizations. The empirical research consists mainly of in-depth interviews and focus groups with activists from social movement organizations which were involved in local social forums.

ECOLOGICAL ETHICS. VALUES AND NORMS IN LOCAL RURAL COMMUNITIES

OpenAIRE

Włodzimierz Kaczocha; Jan Sikora

2016-01-01

An important role in sustainable rural development, involving economy, local communities and nature, should be played by ethics. This paper presents a theoretical and empirical characterization of basic problems of ecological ethics. First and foremost, the study characterizes the philosophical fundamentals of this ethics, with emphasis on ontological and anthropological views of selected thinkers. A universal concept of ecological ethics was proposed, containing values and moral norms that p...

Delta opioid receptor on equine sperm cells: subcellular localization and involvement in sperm motility analyzed by computer assisted sperm analyzer (CASA

Directory of Open Access Journals (Sweden)

Lacalandra Giovanni M

2010-06-01

Full Text Available Abstract Background Opioid receptors and endogenous opioid peptides act not only in the control of nociceptive pathways, indeed several reports demonstrate the effects of opiates on sperm cell motility and morphology suggesting the importance of these receptors in the modulation of reproduction in mammals. In this study we investigated the expression of delta opioid receptors on equine spermatozoa by western blot/indirect immunofluorescence and its relationship with sperm cell physiology. Methods We analyzed viability, motility, capacitation, acrosome reaction and mitochondrial activity in the presence of naltrindole and DPDPE by means of a computer assisted sperm analyzer and a fluorescent confocal microscope. The evaluation of viability, capacitation and acrosome reaction was carried out by the double CTC/Hoechst staining, whereas mitochondrial activity was assessed by means of MitoTracker Orange dye. Results We showed that in equine sperm cells, delta opioid receptor is expressed as a doublet of 65 and 50 kDa molecular mass and is localized in the mid piece of tail; we also demonstrated that naltrindole, a delta opioid receptor antagonist, could be utilized in modulating several physiological parameters of the equine spermatozoon in a dose-dependent way. We also found that low concentrations of the antagonist increase sperm motility whereas high concentrations show the opposite effect. Moreover low concentrations hamper capacitation, acrosome reaction and viability even if the percentage of cells with active mitochondria seems to be increased; the opposite effect is exerted at high concentrations. We have also observed that the delta opioid receptor agonist DPDPE is scarcely involved in affecting the same parameters at the employed concentrations. Conclusions The results described in this paper add new important details in the comprehension of the mammalian sperm physiology and suggest new insights for improving reproduction and for

The technical feasibility of an image-guided intensity-modulated radiotherapy (IG-IMRT) to perform a hypofractionated schedule in terms of toxicity and local control for patients with locally advanced or recurrent pancreatic cancer

International Nuclear Information System (INIS)

Son, Seok Hyun; Song, Jin Ho; Choi, Byung Ock; Kang, Young-nam; Lee, Myung Ah; Kang, Ki Mun; Jang, Hong Seok

2012-01-01

The purpose of this study was to evaluate the technical feasibility of an image-guided intensity modulated radiotherapy (IG-IMRT) using involved-field technique to perform a hypofractionated schedule for patients with locally advanced or recurrent pancreatic cancer. From May 2009 to November 2011, 12 patients with locally advanced or locally recurrent pancreatic cancer received hypofractionated CCRT using TomoTherapy Hi-Art with concurrent and sequential chemotherapy at Seoul St. Mary’s Hospital, the Catholic University of Korea. The total dose delivered was 45 Gy in 15 fractions or 50 Gy in 20 fractions. The target volume did not include the uninvolved regional lymph nodes. Treatment planning and delivery were performed using the IG-IMRT technique. The follow-up duration was a median of 31.1 months (range: 5.7-36.3 months). Grade 2 or worse acute toxicities developed in 7 patients (58%). Grade 3 or worse gastrointestinal and hematologic toxicity occurred in 0% and 17% of patients, respectively. In the response evaluation, the rates of partial response and stable disease were 58% and 42%, respectively. The rate of local failure was 8% and no regional failure was observed. Distant failure was the main cause of treatment failure. The progression-free survival and overall survival durations were 7.6 and 12.1 months, respectively. The involved-field technique and IG-IMRT delivered via a hypofractionated schedule are feasible for patients with locally advanced or recurrent pancreatic cancer

First case report of locally advanced malignant nodular hidradenoma of the scrotum.

Science.gov (United States)

Shah, Binay K; Qamruzzaman, Yusuf; Serban, Karina; Hire, Ervin; Ying, Shan-Ching

2010-01-01

Malignant nodular hidradenoma (MNH) is a malignant tumor of the eccrine glands, and most commonly involves the head, trunk, and extremities. To the best of our knowledge, MNH of the scrotum has not yet been described in the English literature. Despite the use of surgery, chemotherapy, radiotherapy, and hormonal therapy, optimal treatment of MNH is unclear. We describe the case of a 30-year-old African American man who was diagnosed with locally advanced MNH of the scrotum and treated with surgery. More than 2 years after surgery, the patient is without evidence of disease. This is the first case report of MNH of the scrotum. Surgery alone may be sufficient for the treatment of localized or locally advanced MNH. Copyright © 2010 S. Karger AG, Basel.

An exploratory study of the local socio-economic effects of Sizewell B

International Nuclear Information System (INIS)

1982-12-01

This Sizewell B study involved five main tasks: (i) to provide broad estimates of the temporary and permanent accommodation requirements of the proposed Sizewell B workforce and families and the likely level of local supply of accommodation; (ii) to provide broad estimates of the requirements for school places of the accompanied workforce and the likely local supply of such places; (iii) to assess further the wider employment effects of the proposed development on local firms, particularly as potential suppliers of goods and services; (iv) to conduct further studies of the expenditure patterns of power station employees; and (v) to incorporate where relevant the likely effects of a policy of double day shift work (in power station construction) into the predictions. Results of the study are reported. (author)

OS DESAFIOS DO TURISMO RURAL NA VALORIZAÇÃO DA CULTURA LOCAL

Directory of Open Access Journals (Sweden)

Alba Regina Azevedo Arana

2007-12-01

Full Text Available The country tourism is a reality that, by competent professionals planned and assisted, and by enterprising proprietors implanted, can be an important form of diversification of income in the country property, and a local culture preserve opportunity. In such a way, this work has for objective to present the country tourismchallenges in the local culture valuation. The problem discussion is: How can country tourism add value, or to promote valuation, to the local culture? Country tourism securely is a element that can promote and valuate the local culture. It is proven that this activity is capable to generate benefits for all the involved ones. Beyond the economic benefits it brings social benefits, extending work market and growing the demand of services. It makes possible the exploration of new segments of market and still it promotes the rational and cultural exploitation of the e region the ambient conservation.

A sustainable local energy policy. Into a renewable millennium; Politique energetique locale durable: vers un millenaire renouvelable

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-07-01

Renewable energy sources only contribute to a marginal extent to the energy balance of most European towns and cities. Many of them, however, have set ambitious targets for 2010 and have developed programmes to this end. During the seminar organised by Energie-Cites in Verona, around 200 people representing towns and cities from over 20 countries were able to present and exchange experience in all areas related to renewable energy: on practical projects and on their impact on local development, urban planning and employment. It is in towns and cities that energy consumption is the highest and that heat networks working on biomass and buildings equipped with thermal and photovoltaic solar collectors are to be found. Renewable energy has been increasingly gaining ground in urban areas over the last few years for the following reasons: cities are responsible for 80% of total energy consumption and therefore concentrate most of energy needs; the existence of heat networks in densely-populated areas is an incentive to use resources such as biomass or geothermal energy for producing heat or in CHP units; biogas from sewage plants or resulting from the biological treatment of waste is also an urban product; thermal solar systems can often be installed on roof tops to satisfy part of the needs in terms of hot water or space heating and the same applies to photovoltaic solar energy; even wind energy can be promoted, either directly or through green buying procedures. Sustainable urban development depends on the implementation of a sustainable local energy policy based on the involvement of local authorities in improving energy efficiency and developing the use of renewable energy sources in municipal energy supplies. Local development, employment, social integration, the quality of the air - all being major sources of concern for local decision-makers - are stimulated by the promotion of renewable energy sources. Cities are, on account of their size, capable of defining

Tuberculosis control: decentralization, local planning and management specificities.

Science.gov (United States)

Trigueiro, Janaína Von Söhsten; Nogueira, Jordana de Almeida; de Sá, Lenilde Duarte; Palha, Pedro Fredemir; Villa, Tereza Cristina Scatena; Trigueiro, Débora Raquel Soares Guedes

2011-01-01

The goal was to analyze, according to the perception of health managers, the practices that guide tuberculosis control actions in cities in the metropolitan region of João Pessoa - PB, Brazil. This qualitative study involved eight professionals in management functions. Testimonies were collected through semi-structured interviews between May and June 2009 and organized through content analysis. Despite the acknowledged benefits of tuberculosis control action decentralization, local planning indicates the predominance of a bureaucratic model that is restricted to negotiation and supplies. Local programming is centered on the coordinator, which shows a command line and vertical management that lead to the fragmentation of the work process. Management action should follow an innovative and transformative route that surpasses bureaucratic barriers and faces the biggest challenge it is proposed: to balance professional interrelations with a view to improving health work performance.

Financial Strategies for the Romanian Local Public Administration

Directory of Open Access Journals (Sweden)

Attila GYÖRGY

2011-02-01

Full Text Available Public administration reform at all governmental levels constitutes an important component of the transformation process from a centralized system to democratic governance. This process involved important legislative and institutional changes in order to fulfill the principles of a market economy and the European Union standards based on transparency, predictability, accountability, adaptability and effectiveness. Therefore, in a continuing extension of the citizens’ needs, Romanian public administration reform, especially at local level, is concentrated on quality of public services based on citizens’ needs and increased performances in the context of a necessary decrease of budget expenditure, taking into consideration the actual financial constraint. In this context, it is useful to investigate the financial strategies of the local public administration based on the Romanian experiences that consisted in important public resources decline because of the financial crisis.

Colonic localization of indium-111 labeled leukocytes in active Behcet's disease

International Nuclear Information System (INIS)

Harre, R.G.; Conrad, G.R.; Seabold, J.E.

1988-01-01

A patient with known Behcet's disease demonstrated intense colonic localization of In-111 labeled leukocytes. Gastrointestinal involvement had not been previously manifested, but extensive colonic inflammation was documented by endoscopy. This case illustrates the utility of In-111 labeled leukocyte imaging for detecting active bowel disease in a debilitated patient with documented Behcet's vasculitis

Multiple-Localization and Hub Proteins

Science.gov (United States)

Ota, Motonori; Gonja, Hideki; Koike, Ryotaro; Fukuchi, Satoshi

2016-01-01

Protein-protein interactions are fundamental for all biological phenomena, and protein-protein interaction networks provide a global view of the interactions. The hub proteins, with many interaction partners, play vital roles in the networks. We investigated the subcellular localizations of proteins in the human network, and found that the ones localized in multiple subcellular compartments, especially the nucleus/cytoplasm proteins (NCP), the cytoplasm/cell membrane proteins (CMP), and the nucleus/cytoplasm/cell membrane proteins (NCMP), tend to be hubs. Examinations of keywords suggested that among NCP, those related to post-translational modifications and transcription functions are the major contributors to the large number of interactions. These types of proteins are characterized by a multi-domain architecture and intrinsic disorder. A survey of the typical hub proteins with prominent numbers of interaction partners in the type revealed that most are either transcription factors or co-regulators involved in signaling pathways. They translocate from the cytoplasm to the nucleus, triggered by the phosphorylation and/or ubiquitination of intrinsically disordered regions. Among CMP and NCMP, the contributors to the numerous interactions are related to either kinase or ubiquitin ligase activity. Many of them reside on the cytoplasmic side of the cell membrane, and act as the upstream regulators of signaling pathways. Overall, these hub proteins function to transfer external signals to the nucleus, through the cell membrane and the cytoplasm. Our analysis suggests that multiple-localization is a crucial concept to characterize groups of hub proteins and their biological functions in cellular information processing. PMID:27285823

Corruption, regionalization and local governance

Directory of Open Access Journals (Sweden)

Vuković Slobodan V.

2002-01-01

Full Text Available Corruption is old almost as human societies and it was developed simultaneously with enlargement of social and political power, bureaucracy and involvement of the state into market transactions. Specific conditions that are characteristic of Serbian society and that have favorably influenced the growth of corruption are: dissolution/break up of Yugoslavia war in surroundings, economic sanctions and NATO bombing. Besides these basic causes of corruption in Serbia are state control over the economy, lack of the rule of law, and breakdown of social values, that is, anomy and poverty. The lack of the rule of law and the state control of economy, which often occur together, are older conditions, while distorted social values, that is, moral crisis and poverty are newer. Subordination of judicial system to the executive authorities enabled different sorts of bribe and corruption to be tolerated. Therefore, the corruption has spread and became contemporary method of conducting business and almost a common thing, regardless of the party composition of the authorities. This thesis is confirmed by the empirical data: 17.9% of citizens claim that all local officials and corrupted and 48.4% claim that majority of them are. On the other side, only 27.5% of citizens claim that local party officials (all of them or majority accept bribe, and 31.1% claim that only some do. Therefore, we are faced with higher interest in political engagement, because it is becoming a highly profitable occupation and posts in local government are highly appreciated because corruption profit is calculated in advance.

A partnership approach to local energy management between European and Asian cities

International Nuclear Information System (INIS)

Webber, Peter; Pardo, Manuel; Conway, Stewart; Lack, Don; Ferreira, Vasco; Castanheira, Luis

2005-01-01

In Europe, several local areas have a number of years of experience with implementing local energy and greenhouse gas management policies, addressing national and international climate change targets. For example, in the city of Leicester in the UK, local strategies and measures have been implemented over several years to improve the energy efficiency of the Council's own operations and to manage city-wide energy consumption and greenhouse gas emissions. Recently, Leicester has participated in a European Commission funded project, which explores the potential for European local authorities and agencies to use their experience to work with a local area in a developing country where energy demand has been increasing rapidly, addressing climate change and sustainable development issues. The project has aimed to provide support at the local level with developing a framework to minimise energy-related contributions to climate change and air pollution, while giving quality of life benefits. It has used a partnership approach between Leicester, Vila Nova de Gaia municipality in Portugal, and a city in the Gujarat, India. The local level's role in each country in local energy management has been investigated. This has included a baseline assessment of local energy use, renewable energy and climate change issues in each partner city. The most locally relevant energy technologies have been selected and their implementation discussed in the local workshops involving a range of organisations and individuals, with actions being identified to improve the local management of energy, such as raising awareness and ensuring easy access to information

Operational procedure standard for occurrences involving radioactive materials

International Nuclear Information System (INIS)

Piekarz, Leonardo; Rezende, Talita C.; Pinheiro, Christiano J.G.

2017-01-01

This study has as objective to analyze more deeply the actions of response to emergencies involving radioactive materials, in the intent to establish a pattern to the actions performed by the military fire fighters of the Military Fire Brigade of Minas Gerais. To met these goals, it has been attempted to analyze the procedures utilized and recommended, nowadays, for the military fire fighters of CBMMG, and through directed studies, to suggest new actions possible to be executed in the local of the emergency in a way that will not expose the garrison to doses of ionizing radiation that may prejudice them. It is a study of bibliographic, exploratory, and also descriptive nature, realized through a qualitative approach. The techniques used for the research were the analysis of institutional documents, norms and other literature produced by renamed entities in the radiologic and biosafety areas. It was then concluded that CBMMG, through simple actions of response, can provide higher quality and safety in the operations involving radiologic accidents, standing out that the implemented actions nowadays are very beneath the capacity of the corporation, due to the lack of knowledge of the matter by the fire fighters. It was proposed, then, that new actions be implemented and instituted as operational procedures to be used on those emergencies, with the objective of provide a higher safety and professionalism in the attendance to emergencies involving radioactive materials. (author)

Operational procedure standard for occurrences involving radioactive materials

Energy Technology Data Exchange (ETDEWEB)

Piekarz, Leonardo, E-mail: leonardopbm@yahoo.com.br [Academia de Bombeiros Militar de Minas Gerais, Belo Horizonte, MG (Brazil); Rezende, Talita C.; Pinheiro, Christiano J.G., E-mail: talitacolombi@yahoo.com, E-mail: christrieste@yahoo.it [Universidade Federal do Espirito Santo (CCA/UFES), Alegre, ES (Brazil). Programa de Pós-Graduação em Engenharia Química

2017-07-01

This study has as objective to analyze more deeply the actions of response to emergencies involving radioactive materials, in the intent to establish a pattern to the actions performed by the military fire fighters of the Military Fire Brigade of Minas Gerais. To met these goals, it has been attempted to analyze the procedures utilized and recommended, nowadays, for the military fire fighters of CBMMG, and through directed studies, to suggest new actions possible to be executed in the local of the emergency in a way that will not expose the garrison to doses of ionizing radiation that may prejudice them. It is a study of bibliographic, exploratory, and also descriptive nature, realized through a qualitative approach. The techniques used for the research were the analysis of institutional documents, norms and other literature produced by renamed entities in the radiologic and biosafety areas. It was then concluded that CBMMG, through simple actions of response, can provide higher quality and safety in the operations involving radiologic accidents, standing out that the implemented actions nowadays are very beneath the capacity of the corporation, due to the lack of knowledge of the matter by the fire fighters. It was proposed, then, that new actions be implemented and instituted as operational procedures to be used on those emergencies, with the objective of provide a higher safety and professionalism in the attendance to emergencies involving radioactive materials. (author)

Parental involvement and association with adolescents’ fruit and vegetable intake at follow-up

DEFF Research Database (Denmark)

Jørgensen, Sanne Ellegaard; Jørgensen, Thea Suldrup; Aarestrup, Anne Kristine

2016-01-01

involvement was found among 30.5 %, 29.6 % and 39.4 % of the students respectively. Parental involvement was highest among women. More men agreed that the parental newsletters provided new information. Students with a medium and high level of parental involvement ate 47.5 and 95.2 g more FV per day compared...... (≈13- year-olds) in the school year 2010/11. The study included a school component: free FV in class and curricular activities; a local community component: fact sheets for sports- and youth clubs; and a parental component: presentation of Boost at a parent-school meeting, 6 newsletters to parents, 3...... guided student-parent curricular activities, and a student-parent Boost event. Study population: Students whose parent replied to the follow-up survey (n = 347). Data: Questionnaire data from students, parents and teachers at 20 intervention schools. Process evaluation measures: dose delivered, dose...

New interaction paths in the energy landscape: the role of local energy initiatives

NARCIS (Netherlands)

de Boer, Jessica; Zuidema, Christian; Gugerell, Katharina

2018-01-01

Energy transition is an encompassing process which not only involves the energy system but also the landscape in which the energy system is embedded. Renewable energy is triggering new interactions with local landscapes in physical, socio-economic and institutional senses. We capture these

Engaging local businesses in HIV prevention efforts: the consumer perspective.

Science.gov (United States)

Phillips-Guzman, Christina M; Martinez-Donate, Ana P; Hovell, Melbourne F; Blumberg, Elaine J; Sipan, Carol L; Rovniak, Liza S; Kelley, Norma J

2011-07-01

Participation of different community sectors, including the private business sector, is necessary to fight the HIV/AIDS epidemic. Local businesses may be reluctant to participate in HIV prevention because of fear of negative customer reactions and loss of revenue. This study examines the extent to which residents of two communities in San Diego, California, would support HIV prevention initiatives in local businesses. A population-based household survey (N = 200) is conducted in two communities with higher versus lower risk for HIV. The survey includes questions regarding the acceptability of HIV prevention activities, such as condom and brochure distribution in businesses, and history of exposure to HIV prevention activities in local businesses. Most residents agree that (a) business involvement in prevention activities would reduce HIV (92%), (b) free or low-cost condoms available in businesses could prevent the spread of HIV (90.9%) and increase condom accessibility (87%), and (c) they would prefer to shop at businesses that supported HIV prevention versus those that did not (87.4%). These findings suggest that HIV prevention in local businesses would be supported by residents and would be unlikely to adversely affect business profits. This information could be used to design interventions to engage local businesses in HIV-prevention efforts.

Short term and long term radiation protection aspects of a nuclear accident: a Cd-Rom for a better stake holders' involvement

International Nuclear Information System (INIS)

Oudiz, A.; Badie, M.; Brenot, J.

2002-01-01

Many players are involved in managing a nuclear accident apart from radiation protection and nuclear safety experts. In an emergency response situation, the decision making process involves many non-technical players who nonetheless have a major role to play: in France these may include the Prefet, the emergency and civil defence services, the health services, the police, the gendarmerie and local councillors, with advice from the safety and radiological protection authorities and expert evaluation organisations. Within the post-accident response, other players will be involved alongside those already described: professional bodies, particularly farming organisations, residents' associations, those responsible for environmental decontamination, agencies responsible for compensating victims, etc., etc. In both the short and the long-term phases of the crisis management process, it is essential to enable participants who may have very different backgrounds and professional experience to work together with co-operation and mutual understanding. If non-technical players are to contribute effectively, there needs to be a minimum level of mutual understanding between them and the technical players on what the nuclear risk really is and what is the rationale of the short and long term counter-measures aimed at protecting the public and restoring the contaminated environment. Local communities also need to share this basic understanding because their cooperation is required in order to implement the counter-measures properly. Conversely, if the experts are to advise the local authorities properly, they need to understand the criteria on which these local authorities and communities base their decisions: what psycho-sociological factors apply, what logistical support is needed, what are the concerns of the local communities?

Classification of the pattern of pulmonary involvement by computed tomography in patients with non-Hodgkin's lymphoma

International Nuclear Information System (INIS)

Fujita, Jiro; Nagai, Masami; Nakamura, Hiroyuki

1990-01-01

The diagnostic value of computed tomography (CT) was assessed in 17 patients with non-Hodgkin's lymphoma. CT was performed to evaluate the localization and types of pulmonary involvement caused by non-Hodgin's lymphoma. Using CT, it was possible to classify types of pulmonary involvements as hilar and/or mediastinum-nodular (13 cases), hilar and/or mediastinum-diffuse (4 cases), pleural effusion (5 cases), parenchymal-diffuse (1 case), and parenchymal-tumor (1 case). The pattern of hilar and/or mediastinum-diffuse seemed to be specific for lymphoblastic lymphoma. CT is useful to distinguish hilar and/or mediastinum-nodular to hilar and/or mediastinum-diffuse, and to provide better definition of the specific anatomic location of pulmonary involvements. (author)

Stakeholder management in the local government decision-making area: evidences from a triangulation study with the English local government

Directory of Open Access Journals (Sweden)

Ricardo Corrêa Gomes

2006-01-01

Full Text Available The stakeholder theory has been in the management agenda for about thirty years and reservations about its acceptance as a comprehensive theory still remains. It was introduced as a managerial issue by the Labour Party in 1997 aiming to make public management more inclusive. This article aims to contribute to the stakeholder theory adding descriptive issues to its theoretical basis. The findings are derived from an inductive investigationcarried out with English Local Authorities, which will most likely be reproduced in other contexts. Data collection and analysis is based on a data triangulation method that involves case-studies, interviews of validation and analysis of documents. The investigation proposes a model for representing the nature of therelationships between stakeholders and the decision-making process of such organizations. The decision-making of local government organizations is in fact a stakeholder-based process in which stakeholders are empowered to exert influences due to power over and interest in the organization’s operations and outcomes.

Deriving appropriate boundary conditions, and accelerating position-jump simulations, of diffusion using non-local jumping

International Nuclear Information System (INIS)

Taylor, P R; Baker, R E; Yates, C A

2015-01-01

In this paper we explore lattice-based position-jump models of diffusion, and the implications of introducing non-local jumping; particles can jump to a range of nearby boxes rather than only to their nearest neighbours. We begin by deriving conditions for equivalence with traditional local jumping models in the continuum limit. We then generalize a previously postulated implementation of the Robin boundary condition for a non-local process of arbitrary maximum jump length, and present a novel implementation of flux boundary conditions, again generalized for a non-local process of arbitrary maximum jump length. In both these cases we validate our results using stochastic simulation. We then proceed to consider two variations on the basic diffusion model: a hybrid local/non-local scheme suitable for models involving sharp concentration gradients, and the implementation of biased jumping. In all cases we show that non-local jumping can deliver substantial time savings for stochastic simulations. (paper)

Mosquito politics: local vector control policies and the spread of West Nile Virus in the Chicago region.

Science.gov (United States)

Tedesco, Carmen; Ruiz, Marilyn; McLafferty, Sara

2010-11-01

Differences in mosquito control practices at the local level involve the interplay of place, scale and politics. During the Chicago West Nile Virus (WNV) outbreak of 2002, mosquito abatement districts represent distinct suburban clusters of human WNV cases, independent of characteristics of the local population, housing and physical environment. We examine how the contrasting actions of four districts reveal a distinct local politics of mosquito control that may have contributed to local-scale geographic differences in WNV incidence. This politics is rooted in political, economic and philosophical differences within and between administrative boundaries. Copyright © 2010 Elsevier Ltd. All rights reserved.

Pediatric scleroderma: systemic or localized forms.

Science.gov (United States)

Torok, Kathryn S

2012-04-01

Pediatric scleroderma includes 2 major groups of clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). Although both share a common pathophysiology, their clinical manifestations differ. LS is typically confined to the skin and underlying subcutis, with up to a quarter of patients showing extracutaneous disease manifestations such as arthritis and uveitis. Vascular, cutaneous, gastrointestinal, pulmonary, and musculoskeletal involvement are most commonly seen in children with SSc. Treatment of both forms targets the active inflammatory stage and halts disease progression; however, progress needs to be made toward the development of more effective antifibrotic therapy to help reverse disease damage. Copyright © 2012 Elsevier Inc. All rights reserved.

Localization of lesions in aphasia

International Nuclear Information System (INIS)

Hojo, Kei; Watanabe, Shunzo; Tasaki, Hiroichi; Sato, Tokijiro; Metoki, Hirobumi.

1984-01-01

Using a microcomputer, the locus and extent of the lesions, as demonstrated by computed tomography for 127 cases with various types of aphasia were superimposed onto standardized marices. The relationship between the foci of the lesions and the types of aphasia was investigated. Broca aphasics (n=39) : Since the accumulated site of the lesions highly involved the deep structures of the lower part of the precentral gyrus as well as the insula and lenticular nucleus, only 60% of the Broca aphasics had lesions on these areas. This finding has proved to have little localizing value. Wernicke aphasics (n=23) : The size of the lesion was significantly smaller than Broca's aphasia. At least 70% of the patients had the superior temporal lesions involving Wernicke's area and subcortical lesions of the superior and middle temporal gyri. Amnestic aphasics (n=18) : The size of the lesion was smaller than any other types. While there was some concentration of the lesions (maximum 40%) in the area of the subcortical region of the anterior temporal gyrus adjacent to Wernicke's area and the lenticular nucleus, the lesions were distributed throughout the left hemisphere. Amnestic aphasia was thought to be the least localizable. Conduction aphasics (n=11) : The lesions were relatively small in size. Many patients had posterior speech area lesions involving at least partially Wernicke's area. In particular, more than 80% of the conduction aphasics had lesions of the supramarginal gyrus and it's adjacent deep structures. Global aphasics (n=36) : In general, the size of the lesion was very large and 70% of the global aphasics had extensive lesions involving both Broca's and Wernicke's areas. However, there were observations showing that the lesions can be small and confined. (J.P.N.)

Who Manages Space? Eco-DRR and the Local Community

Directory of Open Access Journals (Sweden)

Syarifah Aini Dalimunthe

2018-05-01

Full Text Available The notion of ecosystem-based disaster risk reduction (DRR has only recently emerged in Indonesia. The Indonesian central government now adopts some policies related to ecosystem-based DRR with formal commitments from local administrations. At the implementation level, various activities have taken place, such as mangrove planting and restoration along the coastline to address the rising sea level and the “one billion trees” program to address the urgent issue of deforestation. These governmental activities have involved local communities that reside in the high-risk area, while nonlocal actors, particularly from the private and the nongovernmental sectors, have contributed as a third element to development. This paper examines space management in the context of Eco-DRR, paying special attention to uncertainty and anxiety in the local communities as the government and private sectors engage in development activities that have significant impacts on their present and future lives. The present study pursues this purpose by means of in-depth interview and focus group discussions (FGD with local leaders in mangrove planting and restoration programs. The study took place in a small island community in a part of the Jakarta Megapolitan Region, Indonesia. The results point out that the community feels left behind due to lack of trust in managing the conservation space. Another issue to be addressed is how to improve the democratization of environment management and livelihood base of the local community. Therefore, building confidence and ameliorating relationships between actors within/without the local community should lead to a better Eco-DRR initiative.

Langerhans' cell histiocytosis: pathology, imaging and treatment of skeletal involvement

Energy Technology Data Exchange (ETDEWEB)

Azouz, E. Michel [University of Miami, Pediatric Radiology Section, Department of Radiology, Miami, FL (United States); Saigal, Gaurav [McGill University, Department of Medical Imaging, Quebec (Canada); Rodriguez, Maria M. [University of Miami, Department of Pathology, Miami, FL (United States); Podda, Antonello [University of Miami, Division of Pediatric Hematology/Oncology, Miami, FL (United States)

2005-02-01

Langerhans' cell histiocytosis (LCH) is manifested in a variety of ways, the most common being the eosinophilic granuloma, a localized, often solitary bone lesion that occurs predominantly in the pediatric age group. The hallmark of LCH is the proliferation and accumulation of a specific histiocyte: the Langerhans' cell. In bone this may cause pain and adjacent soft-tissue swelling, but some lesions are asymptomatic. LCH can involve any bone, but most lesions occur in the skull (especially the calvarium and temporal bones), the pelvis, spine, mandible, ribs, and tubular bones. Imaging diagnosis of the disease in bone is first based on the plain radiographic appearance, which is usually a central destructive, aggressive-looking lesion. In the skull, the lesions develop in the diploic space, are lytic, and their edges may be beveled, scalloped or confluent (geographic), or show a ''button sequestrum.'' Vertebral body involvement usually causes collapse, resulting in vertebra plana. With significant recent improvements in the quality of gamma cameras, imaging techniques, and in studying children, bone scintigraphy at diagnosis and on follow-up usually reveals the sites of active disease, especially when the involvement is polyostotic. CT and MR imaging are very useful in providing detailed cross-sectional anatomic detail of the involved bone, including the bone marrow and the adjacent soft tissues. CT is better suited for demonstrating bone detail and MR imaging for bone marrow and soft-tissue involvement. (orig.)

Triple solutions for a Dirichlet boundary value problem involving a perturbed discrete p(k-Laplacian operator

Directory of Open Access Journals (Sweden)

Khaleghi Moghadam Mohsen

2017-08-01

Full Text Available Triple solutions are obtained for a discrete problem involving a nonlinearly perturbed one-dimensional p(k-Laplacian operator and satisfying Dirichlet boundary conditions. The methods for existence rely on a Ricceri-local minimum theorem for differentiable functionals. Several examples are included to illustrate the main results.

Organizing Patient Involvement

DEFF Research Database (Denmark)

Brehm Johansen, Mette

hospitals. During the last 25 years, patient involvement and quality improvement have become connected in Danish healthcare policy. However, the ideal of involving patients in quality improvement is described in very general terms and with only few specific expectations of how it is to be carried out...... in practice, as I show in the thesis. In the patient involvement literature, the difficulties of getting patient involvement in quality improvement to have in an impact on the planning and development of healthcare services is, for example, ascribed to conceptual vagueness of patient involvement, differences...... in perspectives, values and understandings between patients and healthcare professionals, or the lack of managerial attention and prioritization....

Status, challenges and facilitators of consumer involvement in Australian health and medical research

Directory of Open Access Journals (Sweden)

Girgis Afaf

2010-11-01

Full Text Available Abstract Background The emergent international practice of involving consumers in health research is driven, in part, by the growing share of health research that can only be applied in and emerge from knowledge that is shaped by human values and societal contexts. This is the first investigation of its kind to identify the current prevalence, challenges, enabling factors and range of approaches to consumer involvement in health and medical research in Australia. Methods A nation-wide survey of research funding organisations and organisations that conduct research was performed during 2008-2009. Results Marked variation in consumer involvement experience and perceptions exists between research funders and researchers. Research funders were over eight times more likely than organisations conducting research to involve consumers in identifying research needs and prioritising research topics. Across both groups, practical and time constraints were reported as key challenges to involving consumers, while guidelines on consumer involvement and evidence of effect were the most important potential enablers. More than a third of research organisations indicated that when consumer involvement was a condition of research funding, it was an important facilitator of involvement. Conclusion It is no longer simply enough to keep society informed of important scientific breakthroughs. If Australian health research is to take into account important social contexts and consequences, it must involve consumers. A set of minimum consumer involvement standards and associated guidelines, that are agreed and routinely adopted, could ensure that consumers and the Australian community they represent, are given an opportunity to shed light on experiences and local circumstance, and express views and concerns relevant to health research.

Embedding a Recovery Orientation into Neuroscience Research: Involving People with a Lived Experience in Research Activity.

Science.gov (United States)

Stratford, Anthony; Brophy, Lisa; Castle, David; Harvey, Carol; Robertson, Joanne; Corlett, Philip; Davidson, Larry; Everall, Ian

2016-03-01

This paper highlights the importance and value of involving people with a lived experience of mental ill health and recovery in neuroscience research activity. In this era of recovery oriented service delivery, involving people with the lived experience of mental illness in neuroscience research extends beyond their participation as "subjects". The recovery paradigm reconceptualises people with the lived experience of mental ill health as experts by experience. To support this contribution, local policies and procedures, recovery-oriented training for neuroscience researchers, and dialogue about the practical applications of neuroscience research, are required.

Local control of striatal dopamine release

Directory of Open Access Journals (Sweden)

Roger eCachope

2014-05-01

Full Text Available The mesolimbic and nigrostriatal dopamine (DA systems play a key role in the physiology of reward seeking, motivation and motor control. Importantly, they are also involved in the pathophysiology of Parkinson’s and Huntington’s disease, schizophrenia and addiction. Control of DA release in the striatum is tightly linked to firing of DA neurons in the ventral tegmental area (VTA and the substantia nigra (SN. However, local influences in the striatum affect release by exerting their action directly on axon terminals. For example, endogenous glutamatergic and cholinergic activity is sufficient to trigger striatal DA release independently of cell body firing. Recent developments involving genetic manipulation, pharmacological selectivity or selective stimulation have allowed for better characterization of these phenomena. Such termino-terminal forms of control of DA release transform considerably our understanding of the mesolimbic and nigrostriatal systems, and have strong implications as potential mechanisms to modify impaired control of DA release in the diseased brain. Here, we review these and related mechanisms and their implications in the physiology of ascending DA systems.

Gemini Observatory Takes its Local Communities on an Expanding Journey

Science.gov (United States)

Harvey, Janice; Michaud, Peter

2012-08-01

Currently in its 7th year (2011) Hawaii's annual Journey through the Universe (JttU) program is a flagship Gemini Observatory public education/outreach initiative involving a broad cross-section of the local Hawai'i Island astronomical community, the public, educators, businesses, local government officials, and thousands of local students. This paper describes the program, its history, planning, implementation, as well as the program's objectives and philosophy. The success of this program is documented here, as measured by continuous and expanding engagement of educators, the community, and the public, along with formal evaluation feedback and selected informal verbal testimony. The program's success also serves as justification for the planned adaptation of a version of the program in Chile in 2011 (adapted for Chilean educational and cultural differences). Finally, lessons learned are shared which have refined the program for Gemini's host communities but can also apply to any institution wishing to initiate a similar program.

Localized saddle-point search and application to temperature-accelerated dynamics

Energy Technology Data Exchange (ETDEWEB)

Shim, Yunsic; Amar, Jacques G. [Department of Physics and Astronomy, University of Toledo, Toledo, Ohio 43606 (United States); Callahan, Nathan B. [Department of Physics and Astronomy, University of Toledo, Toledo, Ohio 43606 (United States); Department of Physics, Indiana University, Bloomington, Indiana 47405 (United States)

2013-03-07

We present a method for speeding up temperature-accelerated dynamics (TAD) simulations by carrying out a localized saddle-point (LSAD) search. In this method, instead of using the entire system to determine the energy barriers of activated processes, the calculation is localized by only including a small chunk of atoms around the atoms directly involved in the transition. Using this method, we have obtained N-independent scaling for the computational cost of the saddle-point search as a function of system size N. The error arising from localization is analyzed using a variety of model systems, including a variety of activated processes on Ag(100) and Cu(100) surfaces, as well as multiatom moves in Cu radiation damage and metal heteroepitaxial growth. Our results show significantly improved performance of TAD with the LSAD method, for the case of Ag/Ag(100) annealing and Cu/Cu(100) growth, while maintaining a negligibly small error in energy barriers.

Diffusion Monte Carlo approach versus adiabatic computation for local Hamiltonians

Science.gov (United States)

Bringewatt, Jacob; Dorland, William; Jordan, Stephen P.; Mink, Alan

2018-02-01

Most research regarding quantum adiabatic optimization has focused on stoquastic Hamiltonians, whose ground states can be expressed with only real non-negative amplitudes and thus for whom destructive interference is not manifest. This raises the question of whether classical Monte Carlo algorithms can efficiently simulate quantum adiabatic optimization with stoquastic Hamiltonians. Recent results have given counterexamples in which path-integral and diffusion Monte Carlo fail to do so. However, most adiabatic optimization algorithms, such as for solving MAX-k -SAT problems, use k -local Hamiltonians, whereas our previous counterexample for diffusion Monte Carlo involved n -body interactions. Here we present a 6-local counterexample which demonstrates that even for these local Hamiltonians there are cases where diffusion Monte Carlo cannot efficiently simulate quantum adiabatic optimization. Furthermore, we perform empirical testing of diffusion Monte Carlo on a standard well-studied class of permutation-symmetric tunneling problems and similarly find large advantages for quantum optimization over diffusion Monte Carlo.

Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly

Energy Technology Data Exchange (ETDEWEB)

Tannukit, Sissada [Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA Rm103, Los Angeles, CA 90033-1004 (United States); Crabb, Tara L.; Hertel, Klemens J. [Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA 92697-4025 (United States); Wen, Xin [Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA Rm103, Los Angeles, CA 90033-1004 (United States); Jans, David A. [Department of Biochemistry and Molecular Biology, Nuclear Signalling Laboratory, Monash University, Clayton, Victoria 3800 (Australia); Paine, Michael L., E-mail: paine@usc.edu [Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA Rm103, Los Angeles, CA 90033-1004 (United States)

2009-12-18

Tuftelin-interacting protein 11 (TFIP11) is a protein component of the spliceosome complex that promotes the release of the lariat-intron during late-stage splicing through a direct recruitment and interaction with DHX15/PRP43. Expression of TFIP11 is essential for cell and organismal survival. TFIP11 contains a G-patch domain, a signature motif of RNA-processing proteins that is responsible for TFIP11-DHX15 interactions. No other functional domains within TFIP11 have been described. TFIP11 is localized to distinct speckled regions within the cell nucleus, although excluded from the nucleolus. In this study sequential C-terminal deletions and mutational analyses have identified two novel protein elements in mouse TFIP11. The first domain covers amino acids 701-706 (VKDKFN) and is an atypical nuclear localization signal (NLS). The second domain is contained within amino acids 711-735 and defines TFIP11's distinct speckled nuclear localization. The identification of a novel TFIP11 nuclear speckle-targeting sequence (TFIP11-STS) suggests that this domain directly interacts with additional spliceosomal components. These data help define the mechanism of nuclear/nuclear speckle localization of the splicing factor TFIP11, with implications for it's function.

Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain

International Nuclear Information System (INIS)

Lin, Anya M.Y.; Chao, P.L.; Fang, S.F.; Chi, C.W.; Yang, C.H.

2007-01-01

The mechanism underlying sodium arsenite (arsenite)-induced neurotoxicity was investigated in rat brain. Arsenite was locally infused in the substantia nigra (SN) of anesthetized rat. Seven days after infusion, lipid peroxidation in the infused SN was elevated and dopamine level in the ipsilateral striatum was reduced in a concentration-dependent manner (0.3-5 nmol). Furthermore, local infusion of arsenite (5 nmol) decreased GSH content and increased expression of heat shock protein 70 and heme oxygenase-1 in the infused SN. Aggregation of α-synuclein, a putative pathological protein involved in several CNS neurodegenerative diseases, was elevated in the arsenite-infused SN. From the breakdown pattern of α-spectrin, both necrosis and apoptosis were involved in the arsenite-induced neurotoxicity. Pyknotic nuclei, cellular shrinkage and cytoplasmic disintegration, indicating necrosis, and TUNEL-positive cells and DNA ladder, indicating apoptosis was observed in the arsenite-infused SN. Arsenite-induced apoptosis was mediated via two different organelle pathways, mitochondria and endoplasmic reticulum (ER). For mitochondrial activation, cytosolic cytochrome c and caspase-3 levels were elevated in the arsenite-infused SN. In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels. Moreover, arsenite reduced procaspase 12 levels, an ER-specific enzyme in the infused SN. Taken together, our study suggests that arsenite is capable of inducing oxidative injury in CNS. In addition to mitochondria, ER stress was involved in the arsenite-induced apoptosis. Arsenite-induced neurotoxicity clinically implies a pathophysiological role of arsenite in CNS neurodegeneration

Institutional reforms of nuclear emergency preparedness in Japan and its challenges. Case studies on stakeholder involvement in establishing nuclear emergency preparedness in France and its implications for Japan

International Nuclear Information System (INIS)

Sugawara, Shin-etsu

2013-01-01

Based upon the experiences with the accident of Fukushima Daiichi Nuclear Power Station, Japan is now making a comprehensive review of nuclear emergency preparedness. The Nuclear Regulation Authority of Japan has changed drastically its basic concept of nuclear emergency arrangements from their dependence on the prediction methods to advance planning-oriented arrangements. In order to implement such changes in an effective enough manner, this report examines how to improve stakeholder involvement focusing on the French cases, where the Local Information Commissions (CLI) plays a critical role, and thereby derives concrete lessons for Japan. Case studies on CLI's involvement in French nuclear emergency preparedness revealed the following implications for Japan; 1. Improving continuously the disaster prevention plans of local governments and of nuclear utilities thorough recursive cycles of disaster-preparedness drill and its evaluation for the benefits of local inhabitants, 2. Setting appropriate ranges wherein local stakeholders involve constantly in establishing nuclear emergency preparedness without alienating completely other stakeholders, 3. Utilizing the prediction systems not as a means to support decision-making in emergency situations but as a tool for facilitating stakeholder involvement in the phase of advance planning, and 4. Integrating nuclear emergency preparedness into other disaster preventions for reducing complex and unrecognized risks. (author)

Cuscuta europaea plastid apparatus in various developmental stages: localization of THF1 protein.

Science.gov (United States)

Švubová, Renáta; Ovečka, Miroslav; Pavlovič, Andrej; Slováková, L'udmila; Blehová, Alžbeta

2013-05-01

It was generally accepted that Cuscuta europaea is mostly adapted to a parasitic lifestyle with no detectable levels of chlorophylls. We found out relatively high level of chlorophylls (Chls a+b) in young developmental stages of dodder. Significant lowering of Chls (a+b) content and increase of carotenoid concentration was typical only for ontogenetically more developed stages. Lower content of photosynthesis-related proteins involved in Chls biosynthesis and in photosystem formation as well as low photochemical activity of PSII indicate that photosynthesis is not the main activity of C. europaea plastids. Previously, it has been shown in other species that the Thylakoid Formation Protein 1 (THF1) is involved in thylakoid membrane differentiation, plant-fungal and plant-bacterial interactions and in sugar signaling with its preferential localization to plastids. Our immunofluorescence localization studies and analyses of haustorial plasma membrane fractions revealed that in addition to plastids, the THF1 protein localizes also to the plasma membrane and plasmodesmata in developing C. europaea haustorium, most abundantly in the digitate cells of the endophyte primordium. These results are supported by western blot analysis, documenting the highest levels of the THF1 protein in "get together" tissues of dodder and tobacco. Based on the fact that photosynthesis is not a typical process in the C. europaea haustorium and on the extra-plastidial localization pattern of the THF1, our data support rather other functions of this protein in the complex relationship between C. europaea and its host.

Automated Simultaneous Local Ties with GNSS and Robot Tacheometer

Science.gov (United States)

Kallio, Ulla; Lösler, Michael; Bergstrand, Sten; Haas, Rüdiger; Eschelbach, Cornelia

2016-12-01

We have used GPS-based local-tie measurements simultaneously with geo-VLBI observations since 2008 during every geodetic VLBI session at Metsähovi. This system uses gimbal-mounted GNSS antennas that are mounted on the reflector of the Metsähovi 14-m radio telescope. A similar system was installed in 2013 at the Onsala 20-m radio telescope and has been used for a large number of VLBI sessions, including, e.g., the 15-day-long CONT14 campaign. In order to verify the results of the two systems, we performed a dedicated measurement campaign in the framework of the SIB60 project, involving both Metsähovi and Onsala. During this campaign the local ties at the two stations were measured simultaneously during two VLBI sessions in August and September 2015 where both stations participated. The robot tacheometer monitoring system HEIMDALL was used for the automated classical monitoring of the telescopes at both stations. Moreover, additional local terrestrial measurements were performed several times to derive the full IVS-IGS local ties at both sites. The kinematic GPS measurements at the two stations were analyzed with two independently developed analysis programs. We present here the preparations of the campaign, the measurement process, and preliminary results.

Local zoning ordinances -- how they limit or restrict mining

International Nuclear Information System (INIS)

Ingram, H.

1991-01-01

Local regulation of mining by zoning has taken place for a long period of time. The delegation to local municipalities of land use planning, zoning and nuisance abatement authority which may affect mining by state governments has been consistently upheld by appellate courts as valid exercises of the police power. Recently, mine operators and mineral owners have been confronted by efforts of local municipalities, often initiated by anti-mining citizen's groups, to impose more stringent restrictions on mining activities within their borders. In some situations, existing ordinances are being enforced for the first time, in others, new ordinances have been adopted without much awareness or involvement by the public. Enforced to the letter, these ordinances can sterilize large blocks of mineable reserves open-quotes operatingclose quotes or performance standards in excess of SMCRA-based regulatory requirements. It is fair to say that investigation of the potential impacts of local zoning and other related ordinances is essential in the planning for the expansion of existing operations or for new operations. There may be new rules in the game. This paper identifies problem areas in typical open-quotes modernclose quotes ordinances and discusses legal and constitutional issues which may arise by their enforcement in coal producing regions

Involving patients in setting priorities for healthcare improvement: a cluster randomized trial.

Science.gov (United States)

Boivin, Antoine; Lehoux, Pascale; Lacombe, Réal; Burgers, Jako; Grol, Richard

2014-02-20

Patients are increasingly seen as active partners in healthcare. While patient involvement in individual clinical decisions has been extensively studied, no trial has assessed how patients can effectively be involved in collective healthcare decisions affecting the population. The goal of this study was to test the impact of involving patients in setting healthcare improvement priorities for chronic care at the community level. Cluster randomized controlled trial. Local communities were randomized in intervention (priority setting with patient involvement) and control sites (no patient involvement). Communities in a canadian region were required to set priorities for improving chronic disease management in primary care, from a list of 37 validated quality indicators. Patients were consulted in writing, before participating in face-to-face deliberation with professionals. Professionals established priorities among themselves, without patient involvement. A total of 172 individuals from six communities participated in the study, including 83 chronic disease patients, and 89 health professionals. The primary outcome was the level of agreement between patients' and professionals' priorities. Secondary outcomes included professionals' intention to use the selected quality indicators, and the costs of patient involvement. Priorities established with patients were more aligned with core generic components of the Medical Home and Chronic Care Model, including: access to primary care, self-care support, patient participation in clinical decisions, and partnership with community organizations (p Priorities established by professionals alone placed more emphasis on the technical quality of single disease management. The involvement intervention fostered mutual influence between patients and professionals, which resulted in a 41% increase in agreement on common priorities (95%CI: +12% to +58%, p priorities. Patient involvement can change priorities driving healthcare

Clinical implication of negative conversion of predicted circumferential resection margin status after preoperative chemoradiotherapy for locally advanced rectal cancer

Energy Technology Data Exchange (ETDEWEB)

Lee, Nam Kwon [Department of Radiation Oncology, Korea University Medical Center, Korea University College of Medicine, Seoul (Korea, Republic of); Kim, Chul Yong, E-mail: kcyro@korea.ac.kr [Department of Radiation Oncology, Korea University Medical Center, Korea University College of Medicine, Seoul (Korea, Republic of); Park, Young Je; Yang, Dae Sik; Yoon, Won Sup [Department of Radiation Oncology, Korea University Medical Center, Korea University College of Medicine, Seoul (Korea, Republic of); Kim, Seon Hahn; Kim, Jin [Division of Colorectal Surgery, Department of Surgery, Korea University Medical Center, Korea University College of Medicine, Seoul (Korea, Republic of)

2014-02-15

Objective: To evaluate the prognostic implication of the negative conversion of predicted circumferential resection margin status before surgery in patients with locally advanced rectal cancer with predicted circumferential resection margin involvement. Methods: Thirty-eight patients (28 men, 10 women; median age, 61 years; age range, 39–80 years) with locally advanced rectal cancer with predicted circumferential resection margin involvement who underwent preoperative chemoradiotherapy followed by radical surgery were analyzed. Involvement of the circumferential resection margin was predicted on the basis of pre- and post-chemoradiotherapy magnetic resonance imaging. The primary endpoints were 3-year local recurrence-free survival and overall survival. Results: The median follow-up time was 41.1 months (range, 13.9–85.2 months). The negative conversion rate of predicted circumferential resection margin status after preoperative chemoradiotherapy was 65.8%. Patients who experienced negative conversion of predicted circumferential resection margin status had a significantly higher 3-year local recurrence-free survival rate (100.0% vs. 76.9%; P = 0.013), disease-free survival rate (91.7% vs. 59.3%; P = 0.023), and overall survival rate (96.0% vs. 73.8%; P = 0.016) than those who had persistent circumferential resection margin involvement. Conclusions: The negative conversion of the predicted circumferential resection margin status as predicted by magnetic resonance imaging will assist in individual risk stratification as a predictive factor for treatment response and survival before surgery. These findings may help physicians determine whether to administer more intense adjuvant chemotherapy or change the surgical plan for patients displaying resistance to preoperative chemoradiotherapy.

Local order and crystallization of dense polydisperse hard spheres

Science.gov (United States)

Coslovich, Daniele; Ozawa, Misaki; Berthier, Ludovic

2018-04-01

Computer simulations give precious insight into the microscopic behavior of supercooled liquids and glasses, but their typical time scales are orders of magnitude shorter than the experimentally relevant ones. We recently closed this gap for a class of models of size polydisperse fluids, which we successfully equilibrate beyond laboratory time scales by means of the swap Monte Carlo algorithm. In this contribution, we study the interplay between compositional and geometric local orders in a model of polydisperse hard spheres equilibrated with this algorithm. Local compositional order has a weak state dependence, while local geometric order associated to icosahedral arrangements grows more markedly but only at very high density. We quantify the correlation lengths and the degree of sphericity associated to icosahedral structures and compare these results to those for the Wahnström Lennard-Jones mixture. Finally, we analyze the structure of very dense samples that partially crystallized following a pattern incompatible with conventional fractionation scenarios. The crystal structure has the symmetry of aluminum diboride and involves a subset of small and large particles with size ratio approximately equal to 0.5.

Understanding Local Energy Initiatives and Preconditions for Business Opportunities

Energy Technology Data Exchange (ETDEWEB)

Jablonska, B. [ECN Policy Studies, Petten (Netherlands); Oostra, M. [TNO, Delft (Netherlands)

2013-09-15

More and more local bottom-up energy initiatives are emerging. Those involved encounter many barriers during the realization of their ideas. As the generation of renewable energy is mostly included, these local initiatives contribute to the targets set at regional, national and EU level. At the same time, they are an indication that end-users themselves want to be part of the energy transition. What are the reasons for citizens to organize themselves and start and initiative? What kind of barriers do they encounter? What does this mean for roles and responsibilities of professionals? And to what kind of opportunities does this lead for products and services? Answers to these questions provide a solid starting point to develop methods and instruments to stimulate, facilitate and upscale local energy initiatives. This paper bundles the outcomes of three workshops and three additional interviews in the Netherlands as part of the European E-hub project. Conclusions can be drawn on needs and drivers, barriers, risks and solutions (lessons learned), possible roles for professionals and opportunities for new products and services.

Local Recurrence in Rectal Cancer: Anatomic Localization and Effect on Radiation Target

International Nuclear Information System (INIS)

Syk, Erik; Torkzad, Michael R.; Blomqvist, Lennart; Nilsson, Per J.; Glimelius, Bengt

2008-01-01

Purpose: To determine the sites of local recurrence after total mesorectal excision for rectal cancer in an effort to optimize the radiation target. Methods and Materials: A total of 155 patients with recurrence after abdominal resection for rectal cancer were identified from a population-based consecutive cohort of 2,315 patients who had undergone surgery by surgeons trained in the total mesorectal excision procedure. A total of 99 cross-sectional imaging studies were retrieved and re-examined by one radiologist. The clinical records were examined for the remaining patients. Results: Evidence of residual mesorectal fat was identified in 50 of the 99 patients. In 83 patients, local recurrence was identified on the imaging studies. All recurrences were within the irradiated volume if the patients had undergone preoperative radiotherapy or within the same volume if they had not. The site of recurrence was in the lower 75% of the pelvis, anatomically below the S1-S2 interspace for all patients. Only 5 of the 44 recurrences in patients with primary tumors >5 cm from the anal verge were in the lowest 20% of the pelvis. Six recurrences involved the lateral lymph nodes. Conclusion: These data suggest that a lowering of the upper limit of the clinical target volume could be introduced. The anal sphincter complex with surrounding tissue could also be excluded in patients with primary tumors >5 cm from the anal verge

Homeland security: what are the advantages and disadvantages of different local homeland security organizational structures?

OpenAIRE

Fitzpatrick, William Mark

2015-01-01

Approved for public release; distribution is unlimited After the attacks of September 11, 2001, and the creation of the federal Department of Homeland Security in 2002, many local agencies formed their own homeland security entity. Since that time, significant economic downturns have resulted in reductions in the amount of homeland security funding available to local jurisdictions. Another issue involves the lack of a common definition of homeland security and what it entails and how daily...

Pediatric Scleroderma –Systemic and Localized Forms

Science.gov (United States)

Torok, Kathryn S.

2012-01-01

Synopsis statement Pediatric scleroderma includes two major groups of clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). Although both share a common pathophysiology, with an initial inflammatory phase associated with endothelial activation, and a later fibrotic phase evidenced by collagenization of tissue and appreciable skin thickness, their clinical manifestations differ. LS is typically confined to the skin and underlying subcutis, and though not fatal like SSc, up to a quarter of the patients may have extracutaneous disease manifestations, such as arthritis and uveitis. While any organ may be affected in SSc, vascular (Raynaud’s phenomenon), cutaneous (skin thickening), GI, pulmonary and musculoskeletal involvement are most commonly seen in children. Auto-antibody profiles in childhood onset SSc can assist in predicting internal organ involvement. Treatment for both forms of scleroderma targets the active inflammatory stage and halts disease progression; however, progress still needs to be made towards the development of a more effective anti-fibrotic therapy to help reverse disease damage. PMID:22560576

Local self governance in health - a study of it’s functioning in Odisha, India

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Bhuputra Panda

2016-10-01

Full Text Available Abstract Background Local decision making is linked to several service quality improvement parameters. Rogi Kalyan Samitis (RKS at peripheral decision making health units (DMHU are composite bodies that are mandated to ensure accountability and transparency in governance, improve quality of services, and facilitate local responsiveness. There is scant literature on the nature of functioning of these institutions in Odisha. This study aimed to assess the perception of RKS members about their roles, involvement and practices with respect to local decision making and management of DMHUs; it further examined perceptual and functional differences between priority and non-priority district set-ups; and identified predictors of involvement of RKS members in local governance of health units. Methods As members of RKS, health service providers, officials in administrative/managerial role, elected representatives, and officials from other departments (including independent members constituted our study sample. A total of 112 respondents were interviewed across 6 districts, through a multi-stage stratified random sampling; we used a semi-structured interview schedule that comprised mainly of close-ended and some open-ended questions. Descriptive and inferential statistics were used to compare 3 priority (PD and 3 non-priority districts (NPD, categorized on the basis of Infant Mortality Rate (IMR estimates of 2011 as proxy of population health. Governance, human resource management, financial management and quality improvement functions were studied in detail. Opinion about various individual and organizational factors in local self-governance and predictors of involvement were identified. Results The socio-demographic profile and composition of respondents were comparable between PD and NPD. Majority of respondents were ‘satisfied’ with their current roles in the governance of local health institutions. About one-fourth opined that the amount of funds

En bloc urinary bladder resection for locally advanced colorectal cancer: a 17-year experience.

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Li, Jimmy C M; Chong, Charing C N; Ng, Simon S M; Yiu, Raymond Y C; Lee, Janet F Y; Leung, Ka Lau

2011-09-01

En bloc bladder resection is often required for treating colorectal cancer with suspected urinary bladder invasion. Our aim was to review our institutional experience in en bloc resection of locally advanced colorectal cancer involving the urinary bladder over a period of 17 years. The hospital records of 72 patients with locally advanced colorectal cancer who underwent en bloc urinary bladder resection at our institution between July 1987 and December 2004 were retrospectively reviewed. Clinical and oncologic outcomes were evaluated. The mean duration of follow-up was 64.3 months. Genuine tumor invasion into the urinary bladder was confirmed in 34 patients (47%) by histopathology. Forty patients (56%) underwent primary closure of the urinary bladder, while 32 patients (44%) required various kinds of urologic reconstructive procedures. Operative mortality occurred in four patients (6%). The overall postoperative morbidity rate was significantly higher in patients undergoing urologic reconstruction (81% vs. 45%, p = 0.002) when compared to that in patients undergoing primary closure. This was mostly attributable to significantly higher rates of urinary anastomotic leak (21.9% vs. 0%, p = 0.002) and urinary tract infection (50% vs. 18%, p = 0.003) in the urologic reconstruction group. For the 57 patients (79%) who underwent curative resection, the 5-year overall survival rate was 59%, and the local recurrence at 5 years was 15%. Both parameters were not significantly affected by the presence of pathologic bladder invasion or the extent of surgical procedures. En bloc bladder resection for locally advanced colorectal cancer involving the urinary bladder can produce reasonable long-term local control and patient survival.

Dynamic localization in finite quantum dot superlattices

International Nuclear Information System (INIS)

Madureira, Justino R.; Schulz, Peter A.; Maialle, Marcelo Z.

2004-01-01

Full text: The dynamic properties of electrons and holes in low dimensional systems, driven by ac fields, reveal exciting emergent phenomena in the time span around the turn of the century. Such a rich scenario has been established by the concurrent development of powerful theoretical analysis tools, design and realization of high quality nano structured devices, as well as of tunable microwave and T Hz ac field sources. These striking developments made possible the exploration of the interaction of T Hz fields with condensed matter, leading even to biological tissue imaging. Therefore, a microscopic understanding of the T Hz field effects on designed nano structures constitute an important framework for further developments. A very interesting example in this context is the prediction of dynamic localization, which has been a subject of intense research in the past few years, from both theoretical and experimental point of views. The initial prediction states that, within a single band tight-binding approximation, an initially localized particle will return to its initial state following the periodical evolution of a driving pure sinusoidal field. This phenomenon can be simply visualized by the related collapse of the quasi energy mini bands, i.e., the localization of electronic states of a periodic unidimensional structure in real space driven by a field periodic in time. Such collapses occur whenever the field intensity/frequency ratio, eaF/(h/2π)ω, is a root of the zero-order Bessel function of the first kind. The quest for experimental signatures of dynamic localization is an involved task, since a variety of perturbations to an ideal situation is always present in real systems. The question that has to be answered is how the dynamic localization, related to the quasi-energy mini band collapses, may be identified in a context where concurring effects also tend to modify the quasi-energy spectra. For semiconductor superlattices, dynamic localization has been

Intensity-modulated proton therapy for elective nodal irradiation and involved-field radiation in the definitive treatment of locally advanced non-small-cell lung cancer: a dosimetric study.

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Kesarwala, Aparna H; Ko, Christine J; Ning, Holly; Xanthopoulos, Eric; Haglund, Karl E; O'Meara, William P; Simone, Charles B; Rengan, Ramesh

2015-05-01

Photon involved-field (IF) radiation therapy (IFRT), the standard for locally advanced (LA) non-small cell lung cancer (NSCLC), results in favorable outcomes without increased isolated nodal failures, perhaps from scattered dose to elective nodal stations. Because of the high conformality of intensity-modulated proton therapy (IMPT), proton IFRT could increase nodal failures. We investigated the feasibility of IMPT for elective nodal irradiation (ENI) in LA-NSCLC. IMPT IFRT plans were generated to the same total dose of 66.6-72 Gy received by 20 LA-NSCLC patients treated with photon IFRT. IMPT ENI plans were generated to 46 cobalt Gray equivalent (CGE) to elective nodal planning treatment volumes (PTV) plus 24 CGE to IF-PTVs. Proton IFRT and ENI improved the IF-PTV percentage of volume receiving 95% of the prescribed dose (D95) by 4% (P ENI. The mean esophagus dose decreased 16% with IFRT and 12% with ENI; heart V25 decreased 63% with both (all P ENI. Potential decreased toxicity indicates that IMPT could allow ENI while maintaining a favorable therapeutic ratio compared with photon IFRT. Published by Elsevier Inc.

Whither surgical quality assurance of breast cancer surgery (surgical margins and local recurrence) after paterson.

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Bundred, N J; Thomas, J; Dixon, J M J

2017-10-01

The Kennedy report into the actions of the disgraced Breast Surgeon, Paterson focussed on issues of informed consent for mastectomy, management of surgical margins and raised concerns about local recurrence rates and the increasing emphasis on cosmesis after mastectomy for breast cancer. This article assesses whether Kennedy's recommendations apply to the UK as a whole and how to address these issues. New GMC advice on consent and newer nonevidenced innovations in immediate reconstruction have altered the level of informed consent required. Patients deserve a better understanding of the issues of oncological versus cosmetic outcomes on which to base their decisions. Involvement of the whole multidisciplinary team including Oncologists is necessary in surgical planning. Failure to obtain clear microscopic margins at mastectomy leads to an increased local recurrence, yet has received little attention in the UK. Whereas, other countries have used surgical quality assurance audits to reduce local recurrence; local recurrence rates are not available and the extent of variation across the UK in margin involvement after surgery, its management and relationship to local recurrence needs auditing prospectively to reduce unnecessary morbidity. To reassure public, patients and the NHS management, an accreditation system with more rigour than NHSBSP QA and peer review is now required. Resource and efforts to support its introduction will be necessary from the Royal College of Surgeons and the Association of Breast Surgeons. New innovations require careful evaluation before their backdoor introduction to the NHS. Private Hospitals need to have the same standards imposed.

Citizen involvement in sustainability-centred environmental assessment follow-up

International Nuclear Information System (INIS)

Hunsberger, Carol A.; Gibson, Robert B.; Wismer, Susan K.

2005-01-01

In Canada, many project proponents and planners in the public and private sectors are required to forecast and minimize the adverse environmental effects of their undertakings. However, environmental assessments have traditionally been weak in the areas of planning and conducting effective monitoring, encouraging public participation, integrating social and ecological considerations, encouraging environmental rehabilitation and enhancement, and examining cumulative effects of multiple projects. This paper attempts to address these deficiencies together by drawing from theory and practice in citizen-based monitoring, in the interests of sustainable livelihoods, using local knowledge. Informed by case study research in several regions of Canada, the discussion focuses on opportunities for using citizen-based approaches to broad and continuing regional monitoring as a foundation for the project-centred work that is the usual concern of environmental assessment follow-up. Such approaches have advantages beyond the usual expectations of project-centred monitoring and beyond the conventional arguments for increasing local involvement in environmental assessments. However, there are also challenges including those of integrating local and conventional (or scientific) knowledge systems, addressing concerns about the credibility and biases of citizens and project proponents, ensuring attention to broader sustainability goals such as increased stewardship and civility, and developing practical ways of coordinating and funding integrated and participatory monitoring programs. The concluding recommendations call for a dramatically different approach to follow-up activities on the part of private and public project proponents, as well as novel thinking for environmental assessment practitioners

[The contributions of local authorities to regional public health policy].

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de Maria, Florence; Grémy, Isabelle

2009-01-01

Local authorities in France are key players in shaping public health policy by their action on the determinants of health and through their actions aimed at specific population groups. Since the public health act of 9 August 2004 establishing the first regional public health plans, their level of involvement and role continues to grow as coordinators, funders and project managers within the greater Paris metropolitan region. Their active participation in regional policy to improve population health and reduce inequalities in health has led to a better organization of the public health programs implemented (in terms of visibility, dialogue, coordination, transparency, and better awareness of context and integration of local issues). Their participation is also a source of innovation resulting in the proposal and use of new approaches (such as the development of health surveillance and observation for advising the local decision-making process). Within the current context of the "Hospitals, patients, health and territories" bill, which entrusts the governance of regional health policy to a specific agency, the role given to local authorities in this new organizational structure must be clearly defined to take into account all of their existing and potential contributions to public health policy.

Local Open Innovation: How to Go from Ideas to Solutions

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Oscar Smulders

2013-03-01

Full Text Available Local open innovation can be used to create a powerful dynamic within a local multi-stakeholder environment. This article shares the experiences of setting up a collaborative innovation process in a regional initiative in the Netherlands. In the first phase of the process, a couple of interactive idea generating sessions have been organized. These so called Quest for Solutions sessions have not only generated a rich set of useful solutions, but they also created a positive vibe within the local community. Factors that have contributed to the success of the idea generation sessions are working around real-life problems involving people who are directly affected by the problem. The structure of the sessions with alternating phases of divergence, exploration, and convergence allowed for broad understanding of the problems, exploration of potential solutions, and working towards result-oriented value statements. Key challenges in translating the ideas into solutions have been determining the value case and dealing with intellectual property. Special attention is given to the notion of innovative contract design as a means of dealing with intellectual property in an environment of local open innovation.

Inguinal hernia repair with tension-free hernioplasty under local anesthesia

International Nuclear Information System (INIS)

Gao, Jia-Sen; Wang, Zhen-Jun; Zhao, Bo; Ma Song Zhang; Pang, Guo-Yi; Na, Dong-Ming; Zhang Yu-Dong

2009-01-01

To evaluate the use of local anesthesia in tension-free hernioplasty in a local hospital. The study took place at Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China during the period from January 2007 to May 2008. All 110 patients who had undergone inguinal hernia repair with mesh under local anesthesia were included in the study. To increase the homogeneity of the sample, we excluded umbilical hernia repairs, parastomal hernia repairs, non-elective procedures, procedures not involving mesh, and repairs performed concurrently with another surgical procedure. We performed a retrospective review of all 110 patients' data. The average operating time was 45 minutes (30-70 minutes), and the average hospital stay was 3-4 days. There was no postoperative mortality in this study. No surgical site infection occurred. Two patients (18%) that suffered from a moderate scrotal hematoma had recovered after extract injection therapy was applied. The duration of incisional pain was 2-3 days, and no patient required post-operative analgesia. During the follow-up, no recurrence occurred. The use of local anesthesia in inguinal hernia repair with tension-free hernioplasty is a safe and effective alternative for inpatient treatment. (aothor)

Beyond Bell's theorem: realism and locality without Bell-type correlations.

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De Zela, F

2017-11-06

The long-lasting view of entanglement as the characteristic trait of quantum mechanics has been recently challenged by experimental demonstrations of non-quantum entanglement. This motivates a review of the meaning of Bell violations, which have been widely taken to prove the impossibility of a realistic interpretation of quantum mechanics and as a manifestation of its non-local character. This work provides new theoretical evidence for the need of reviewing the meaning of Bell violations, especially when they occur outside the quantum framework. We present a local-realistic model that reproduces quantum predictions concerning Bell tests. We claim that local-realism is fully compatible with correlations that are not of the Bell type and therefore lie outside the scope of Bell's theorem. Most experimental Bell tests involve either spin vectors spanning the Bloch sphere or Stokes vectors spanning the Poincaré sphere. A suitable statistical tool that allows assessing correlations between vectors is given by inner-product-type correlations. Using them, it is possible to reproduce quantum predictions for all Bell states, thereby explaining experimental results of Bell tests within a local-realistic framework.

Methodological challenges involved in compiling the Nahua pharmacopeia.

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De Vos, Paula

2017-06-01

Recent work in the history of science has questioned the Eurocentric nature of the field and sought to include a more global approach that would serve to displace center-periphery models in favor of approaches that take seriously local knowledge production. Historians of Iberian colonial science have taken up this approach, which involves reliance on indigenous knowledge traditions of the Americas. These traditions present a number of challenges to modern researchers, including availability and reliability of source material, issues of translation and identification, and lack of systematization. This essay explores the challenges that emerged in the author's attempt to compile a pre-contact Nahua pharmacopeia, the reasons for these challenges, and the ways they may - or may not - be overcome.

From Local to EXtreme Environments (FLEXE) Student-Scientist Online Forums: hypothesis-based research examining ways to involve scientists in effective science education

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Goehring, L.; Carlsen, W.; Fisher, C. R.; Kerlin, S.; Trautmann, N.; Petersen, W.

2011-12-01

Science education reform since the mid-1990's has called for a "new way of teaching and learning about science that reflects how science itself is done, emphasizing inquiry as a way of achieving knowledge and understanding about the world" (NRC, 1996). Scientists and engineers, experts in inquiry thinking, have been called to help model these practices for students and demonstrate scientific habits of mind. The question, however, is "how best to involve these experts?" given the very real challenges of limited availability of scientists, varying experience with effective pedagogy, widespread geographic distribution of schools, and the sheer number of students involved. Technology offers partial solutions to enable Student-Scientist Interactions (SSI). The FLEXE Project has developed online FLEXE Forums to support efficient, effective SSIs, making use of web-based and database technology to facilitate communication between students and scientists. More importantly, the FLEXE project has approached this question of "how best to do this?" scientifically, combining program evaluation with hypothesis-based research explicitly testing the effects of such SSIs on student learning and attitudes towards science. FLEXE Forums are designed to showcase scientific practices and habits of mind through facilitated interaction between students and scientists. Through these Forums, students "meet" working scientists and learn about their research and the environments in which they work. Scientists provide students with intriguing "real-life" datasets and challenge students to analyze and interpret the data through guiding questions. Students submit their analyses to the Forum, and scientists provide feedback and connect the instructional activity with real-life practice, showcasing their activities in the field. In the FLEXE project, Forums are embedded within inquiry-based instructional units focused on essential learning concepts, and feature the deep-sea environment in contrast

Aggressive Angiomyxoma Involving Penis and Urethra – A Case Report

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Shivashankar Damodaran

2017-07-01

Full Text Available Aggressive angiomyxoma is a rare benign mesenchymal stromal tumour, characterized by locally infiltrative nature and a tendency for recurrence. Only a few cases of penile involvement have been reported in the literature so far. We report a case of aggressive penile angiomyxoma in a sixty-two-year-old obese, diabetic male patient. He presented with obstructive lower urinary tract symptoms (LUTS and diffuse enlargement of the penis and scrotum. He was managed with excision, reduction scrotoplasty, internal urethrotomy, followed by Leuprolide therapy for prevention of recurrence. He is on follow up for 20 months without recurrence and obstructive symptoms.

New Communication Technologies, Local Journalism and the Perception of Locality

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Ali ÖZCAN

2016-12-01

Full Text Available Studies on local journalism as an important element of participatory democracy generally focus on the history of the local press, the financial insufficiencies of local newspapers as well as technical/ technological incompetency that occurs as a result of these factors. This research analyzes local newspapers with a new scientific point of view by focusing on the perception of locality as a mental projection of geographical constraint. Perspectives regarding the transformations on perceptions of locality as a result of the disappearance of time and space constraints due to new communication technologies, and the opportunities that new communication environments offer to local newspapers will be provided. Moreover, the ways in which local newspapers reflect on locality with their printed versions under time and space constraints will be analyzed. The research scope of the study has been limited to 15 newspapers in Konya. Structured interviews and content analysis methods were used for data collection and analysis.

Dirty Water, Muddied Politics: Hybridisation of Local and National Opposition to Kumtor Mine, Kyrgyzstan

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Joseph Horrocks-Taylor

2018-04-01

Full Text Available From a Mongolian ‘super mine’ to China’s One Belt One Road, rapid infrastructural development is reforging Central Asia as an economic pivot of the future. Such development offers enticing economic benefits, but threatens fragile environments and local livelihoods. Due to the weakness of the state, the emphasis will be on citizens to hold developers accountable to their social and environmental pledges. Reports of political elites influencing the demands of popular protests call into question the ability of citizens to fulfil this function. This paper examines protest authenticity in Kyrgyzstan, focusing on an environmental social movement against Kumtor gold mine. We trace the emergence and evolution of the social movement, identifying the flexible discursive and scalar strategies it uses to achieve emphasis of the local level and relevance on the national scale. The discussion focuses on how national political saliency may incentivise elite involvement with social movements. This involvement can mask the local demands of the social movement, fixing the environmental problem as a national issue. It is crucial to understand the scalar dynamics of elite-protest interaction if Central Asian civil society is to hold future infrastructural developments to account.

On hyperbolic U4 manifolds with local duality

International Nuclear Information System (INIS)

Wallner, R.P.

1982-01-01

We use the decomposition of the Riemann/Cartan curvature 2-forms Ωsup(ij) in terms of their irreducible parts under the Lorentz group to examine the irreducible content of self- and anti-self double dual curvature forms Ωsup(+-ij) and their further refinements involving left and right duals. In the case of local duality (i.e. Ωsup(ij) = Ωsup(+-ij) locally), some consequences to curvature and torsion are easily derived in this way. As Riemann/Cartan space-times (U 4 -space-times) are subject to generalized gravity theories, some (vacuum) field equations proposed there are also taken into considerations. As an application to the various decompositions of curvature and torsion we point out their utility in the search of exact solutions of U 4 -field equations. To simplify notations and calculations, the calculus of exterior forms is used throughout. (Author)

Streamwise-Localized Solutions with natural 1-fold symmetry

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Altmeyer, Sebastian; Willis, Ashley; Hof, Björn

2014-11-01

It has been proposed in recent years that turbulence is organized around unstable invariant solutions, which provide the building blocks of the chaotic dynamics. In direct numerical simulations of pipe flow we show that when imposing a minimal symmetry constraint (reflection in an axial plane only) the formation of turbulence can indeed be explained by dynamical systems concepts. The hypersurface separating laminar from turbulent motion, the edge of turbulence, is spanned by the stable manifolds of an exact invariant solution, a periodic orbit of a spatially localized structure. The turbulent states themselves (turbulent puffs in this case) are shown to arise in a bifurcation sequence from a related localized solution (the upper branch orbit). The rather complex bifurcation sequence involves secondary Hopf bifurcations, frequency locking and a period doubling cascade until eventually turbulent puffs arise. In addition we report preliminary results of the transition sequence for pipe flow without symmetry constraints.

Implementing ITI for urban development locally

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Garyfallia Katsavounidou

2017-12-01

Full Text Available In the current Programming Period (2014-2020 the European Commission has introduced a new strategic instrument, the Integrated Territorial Investment (ITI, which shifts the decisions on allocation of funds to the local level and, most importantly, enables drawing of funds from several priority axes and from several European Structural and Investment Funds. Greece is one of EU member countries that has committed on using ITIs as a tool for urban development. In August 2016, in the Region of Central Macedonia, urban authorities with a population of over 10.000 inhabitants were invited by the Managing Authority of the Regional Operational Programme to submit a Strategy for Sustainable Urban Development (SUD, through the mandatory implementation of the ITI tool. The paper focuses on one of these municipalities, the city of Veria, where the ITI approach has been implemented for the design of an ITI of urban scale (ITI-SUD. The integrated approach prescribed by regional authorities forced Municipalities to adopt government approaches uncommon until now: to involve multiple stakeholders in the entire process, from strategy development to project selection and implementation. The paper describes the benefits and challenges of the new approach as applied in the local context, showing the vertical and horizontal connections of urban development strategies. Most importantly, in the context of ‘procedural learning’ happening in Europe in the field of territorial cohesion, it offers an insight on how European cohesion policy strategies and tools are tested at the local level.

New developments in juvenile systemic and localized scleroderma.

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Foeldvari, Ivan

2013-11-01

Juvenile localized scleroderma (jLS) and juvenile systemic sclerosis (jSS) are both orphan diseases, with jLS around 10 times more frequent than jSS. In recent years the time gap between the appearance of symptoms and diagnosis has become significantly shorter. This review focuses on the new classifications of jSS and jLS, and on the developments and adaptations of the outcome measures for certain organ involvements whereby progress has been made regarding pediatric patients. Copyright © 2013 Elsevier Inc. All rights reserved.

Co-localization patterns of neurotensin receptor 1 and tyrosine hydroxylase in brain regions involved in motivation and social behavior in male European starlings.

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Merullo, Devin P; Spool, Jeremy A; Zhao, Changjiu; Riters, Lauren V

2018-04-01

Animals communicate in distinct social contexts to convey information specific to those contexts, such as sexual or agonistic motivation. In seasonally-breeding male songbirds, seasonal changes in day length and increases in testosterone stimulate sexually-motivated song directed at females for courtship and reproduction. Dopamine and testosterone may act in the same brain regions to stimulate sexually-motivated singing. The neuropeptide neurotensin, acting at the neurotensin receptor 1 (NTR1), can strongly influence dopamine transmission. The goal of this study was to gain insight into the degree to which seasonal changes in physiology modify interactions between neurotensin and dopamine to adjust context-appropriate communication. Male European starlings were examined in physiological conditions that stimulate season-typical forms of communication: late summer/early fall non-breeding condition (low testosterone; birds sing infrequently), late fall non-breeding condition (low testosterone; birds produce non-sexually motivated song), and spring breeding condition (high testosterone; males produce sexually-motivated song). Double fluorescent immunolabeling was performed to detect co-localization patterns between tyrosine hydroxylase (TH; the rate-limiting enzyme in dopamine synthesis) and NTR1 in brain regions implicated in motivation and song production (the ventral tegmental area, medial preoptic nucleus, periaqueductal gray, and lateral septum). Co-localization between TH and NTR1 was present in the ventral tegmental area for all physiological conditions, and the number of co-localized cells did not differ across conditions. Immunolabeling for TH and NTR1 was also present in the other examined regions, although no co-localization was seen. These results support the hypothesis that interactions between NTR1 and dopamine in the ventral tegmental area may modulate vocalizations, but suggest that testosterone- or photoperiod-induced changes in NTR1/TH co-localization