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Sample records for lle tamm hans

  1. LLE Review

    Energy Technology Data Exchange (ETDEWEB)

    Keck, R.L. (ed.)

    1992-01-01

    This volume of the LLE Review, covering the period January--March 1992, contains articles on the use of diffraction gratings in laser applications, and the fabrication of gratings for use in these applications. there are two articles on the use of lasers to explore fundamental physics issues and an article on the use of a solid-state diode array for x-ray imaging. Finally, the activities of the National Laser Users Facility and the GDL and OMEGA laser systems are summarized.

  2. LLE review

    Energy Technology Data Exchange (ETDEWEB)

    Keck, R.L. (ed.)

    1991-01-01

    This volume of the LLE Review, covering the period October-December 1991, contains articles on the analysis of argon-filled target experiments, and a theoretical analysis of the impact of nonlocal heat transport in laser filamentation in plasmas. In the Advanced Technology section there is an article on mechanisms that affect thin-film conductivity, and a report on the gain characteristics of the 20-cm SSA prototype amplifier to be used in the OMEGA Upgrade. Finally, the activities of the National Laser Users Facility and the GDL and OMEGA laser facilities are summarized. Highlights of the research reported in this issue are: argon radiation from argon-filled, polymer-shell targets is used as a core-temperature diagnostic and density diagnostic of the surrounding region in a regime where the argon line radiation is strongly absorbed. A theoretical analysis of the impact of nonlocal heat transport on laser filamentation in plasmas is developed. The resulting model is compared with experimental observations and the implications for ICF are discussed. A study of thermal conductivity in thin films seeks to identify mechanisms that result in degradation of thin-film conductivity. Identifying these mechanisms can lead to changes in the thin-film manufacture that will improve their resistance to laser damage.

  3. Raamatulett / Jaanus Tamm

    Index Scriptorium Estoniae

    Tamm, Jaanus

    1996-01-01

    Hõkansson, Jan. Isa purjetab; Swarthout, Glendon. Õnnista loomi ja lapsi; Huxley, Aldous. Nood koltunud lehed; Hesse, Hermann. Narziss ja Goldmund; Olsen, Lars-Erik. Puutumata maa; Tamm, Jaanus. Öö

  4. Kolga koolis andsid tunde hiinlased / Ülle Tamm

    Index Scriptorium Estoniae

    Tamm, Ülle

    2016-01-01

    Tallinna Ülikooli Konfutsiuse Instituudi neli õppejõudu - Zhuoya Wu, Xiuping Huang, Sandra Sainio ja Kristiina Kraft viisid Kolga koolis toimunud Hiina päeval läbi töötubasid ja loenguid hiina keelest ja kultuurist

  5. Raamatulett / Jaanus Tamm

    Index Scriptorium Estoniae

    Tamm, Jaanus

    1996-01-01

    Põder, Rein. Armastuse hääl; Schmidt, Erik. Pagana eestlane!; Lina, Jüri. Skorpioni märgi all; Nesser, Hõkan, Tagasitulek; Fallada, Hans. Tookord meil isakodus; Fitzgerald, Francis Scott. Suur Gatsby

  6. Ralf Tamm - unistaja tehismaastikul / Ralf Tamm ; interv. Aino Ingrid Sepp

    Index Scriptorium Estoniae

    Tamm, Ralf

    2008-01-01

    Eramuile spetsialiseerunud arhitekt Ralf Tamm sellest, miks ta eelistab projekteerida eramuid, eramust visiooni kujunemisest, betoonist, hea arhitektuuri loomise eeldustest, eesti arhitektuuri lähitulevikust, tuleviku töövahenditest, enda tööstiilist jm. Abikaasa disainer Angela Orgusaar Ralf Tammest. Eramu "Vana laev" tellija Tarmo Ojakääru kommentaar. 13 ill

  7. Tamm ja Asi / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Näitus "Sisearhitektid Väino Tamm & Vello Asi" Eesti Arhitektuurimuuseumis kuni 2. IX. Kuna valminud objektidest ei ole enam ühtegi originaalkujul alles, on eksponeeritud võimalikult suurel hulgal valmimisjärgseid fotosid, millest enamiku on teinud Rein Vainküla

  8. Ertebølle Cuisine

    DEFF Research Database (Denmark)

    Philippsen, Bente

    . Those minerals originate from carbonate rocks, having infinite ages compared to the 14C time scale. This effect is called the “hardwater effect”. Thus the question of what Ertebølle people cooked in their pots is not only interesting in itself, but also helps in finding out whether the radiocarbon...... crust by stable isotope measurements? Is a fish’s reservoir age the same as that of the food crust made from this fish? In addition to recent materials, I examined archaeological remains from the two inland sites Kayhude and Schlamersdorf, where the presumably oldest Ertebølle pottery had been found...

  9. Perehdytysopas yritys X:lle

    OpenAIRE

    Raappana, Emilia

    2015-01-01

    Toimeksiantajana tälle toiminnalliselle opinnäytetyölle toimii yritys X, joka on suuri Pohjoismaissa toimiva finanssialan yritys. Yrityksessä toimii eräs vasta vuosi sitten perustettu tiimi, jolla ei ole omaa perehdytysopasta lainkaan, vaan perehdytysprosessiin on otettu osia toisilta tiimeiltä. Tästä johtuen perehdytysmallista on puuttunut struktuuri eikä sen laatua ole juurikaan valvottu. Perehdytysoppaalle oli siis suuri tarve yrityksessä, joten se valikoitui opinnäytetyön aiheeksi. Yritys...

  10. Controllable Tamm states in magnetophotonic crystal

    Energy Technology Data Exchange (ETDEWEB)

    Merzlikin, A.M. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation); Vinogradov, A.P. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation)]. E-mail: a-vinogr@yandex.ru; Dorofeenko, A.V. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation); Inoue, M. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1 Hibari-Ga-Oka, Tempaku, Toyohashi 441-8580 (Japan); Levy, M. [Department of Physics, Michigan Technological University, 1400 Townsend Drive Houghton, MI 49931-1295 (United States); Granovsky, A.B. [Faculty of Physics, M.V. Lomonosov Moscow State University, Vorob' evy Gory, 119992 Moscow (Russian Federation)

    2007-05-15

    We study the Tamm states existing at the interface of a 1D magnetophotonic crystal made of magneto-optic material and a material with natural anisotropy. It is shown that in such a photonic crystal (PC) Yeh's band gap may exist, which causes a special type of the Tamm state. As this state is due to magneto-optic properties, it is controllable by an external magnetic field.

  11. Controllable Tamm states in magnetophotonic crystal

    International Nuclear Information System (INIS)

    Merzlikin, A.M.; Vinogradov, A.P.; Dorofeenko, A.V.; Inoue, M.; Levy, M.; Granovsky, A.B.

    2007-01-01

    We study the Tamm states existing at the interface of a 1D magnetophotonic crystal made of magneto-optic material and a material with natural anisotropy. It is shown that in such a photonic crystal (PC) Yeh's band gap may exist, which causes a special type of the Tamm state. As this state is due to magneto-optic properties, it is controllable by an external magnetic field

  12. Jiecai Han

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Jiecai Han. Articles written in Bulletin of Materials Science. Volume 25 Issue 4 August 2002 pp 263-266 Synthesis. Self-propagating high temperature synthesis and magnetic properties of Ni0.35Zn0.65Fe2O4 powders · Yao Li Jiupeng Zhao Jiecai Han · More Details Abstract ...

  13. Ülle Marksile Ungarist preemia

    Index Scriptorium Estoniae

    2008-01-01

    7.-27. juulini 2008. a. toimus Györis Ungari kultuuriministeeriumi ja Györi kunstimuuseumi koostöös 40. rahvusvaheline kunstnike sümpoosion. Eestist osalesid Ülle Marks ja Jüri Kass. Sümpoosioni võitjaks kuulutati graafik Ülle Marks kuivnõeltehnikas seeriaga "Minu teekond"

  14. Eesti kirjandus Prantsusmaal 2002 : jälle ebaharilikult priske saak / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2003-01-01

    2002. a. ilmus prantsuse keeles neli eesti kirjandusteost: Antoine Chalvini koostatud novellivalimik "Les hirondelles" ("Pääsukesed"); Eva Koffi näidend " Meie isa" ("Notre père", tõlkija Eva Toulouze); Jaan Kaplinski tõlkekogu "Le désir de la poussière" ("Tolmu igatsus", koostaja ja tõlkija Antoine Chalvin); Karl Ristikivi "Inimese teekond" ("Chemin terrestre", tõlkija Tarah Montbélialtz, pseud.)

  15. Kuusalu vallavanem Herko Sunts otsustas kandideerida Tartu maavanemaks / Herko Sunts ; interv. Ülle Tamm

    Index Scriptorium Estoniae

    Sunts, Herko

    2004-01-01

    Kuusalu vallavanem põhjendab kandideerimist Tartu maavanemaks ja annab hinnangu oma tööle vallavanemana. Kommentaar Kuusalu vallavolikogu esimehelt Kalmer Märtsonilt. Vt. samas: Tartu maavanema kandidaadid

  16. Kuusalu vallavanemana jätkab Herko Sunts / Ülle Tamm

    Index Scriptorium Estoniae

    Tamm, Ülle, 1962-

    2005-01-01

    Kuusalu vallavolikogu valis 11 häälega vallavanemaks seni sama ametit pidanud Herko Suntsi. Valimisliitude Ühiselt Edasi ja Meie Kodu koalitsioonileping jäi sõlmimata. Vt. samas intervjuud Herko Suntsiga

  17. Lahemaa RPA vaidlustas Valgejõe paisutamise Nõmmeveskil / Ülle Tamm

    Index Scriptorium Estoniae

    Tamm, Ülle, 1962-

    2004-01-01

    Keskkonnainspektsioon uurib Lahemaa Rahvuspargi administratsiooni palvel AS-i Maru poolt Valgejõele tekitatud paisjärve mõjusid looduskeskkonnale. Paisjärve toetuseks võtavad sõna külavanem Ira Laasi, Loksa vallavanem Madis Praks ja AS-i Maru juhatuse liige Heiki Laiverik. Lahemaa Rahvuspargi seisukohta selgitab Lauri-Indrek Tummeleht

  18. Peliohjelmointi Windows Phone 8:lle

    OpenAIRE

    Bäckström, Toni

    2014-01-01

    Tässä insinöörityössä tutustutaan Windows Phone 8 -mobiilikäyttöjärjestelmään peliohjelmoijan näkökulmasta. Työn tavoitteena oli erityisesti esitellä Microsoftin itse kehittämiä XNA- ja DirectX-peliohjelmointikirjastoja teoriassa ja käytännössä. Työn aluksi käydään läpi hieman Windows Phonen historiaa ja yleisesti kehittämistä Windows Phone 8:lle. Tämän jälkeen luodaan katsaus Windows Phone 8:aan pelialustana. Työn suurin osuus on XNA:n ja DirectX:n esittely teoriassa; kummastakin men...

  19. LLE Review 101 (October-December 2004)

    Energy Technology Data Exchange (ETDEWEB)

    Shmayda, W. T. [editor

    2005-03-01

    This volume of the LLE Review, covering October to December 2004, highlights the significance of shaped adiabats to inertial confinement fusion. Theory suggests that inertial confinement fusion (ICF) capsules compressed by shaped adiabats will exhibit improved hydrodynamic stability.

  20. Henri Tamm : algul küsiti mult kogu aeg autogrammi / Henri Tamm ; interv. Ada Kallam

    Index Scriptorium Estoniae

    Tamm, Henri

    2005-01-01

    Draamaseriaali "Kodu keset linna" lapsnäitleja. Lisaks kolleegid Henrist : M. Veinmann "Tekst on tal esimesena peas", K. Maibaum "Võrdväärne partner suurtele". Artikkel pealkirjaga "Henri Tamm : nüüd saan veidi puhkust" : Linnaleht nr. 22, 3. juuni 2005, A2-A3

  1. LLE Review 83, Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2000-12-01

    This volume of the LLE Review, covering April-June 2000, features an article by F. J. Marshall, T. Ohki, D. McInnis, Z. Ninkov, and J. Carbone, who detail the conversion of the OMEGA time-integrated x-ray diagnostics to electronic readout using direct-detection x-ray cameras [charge-injection devices (CID's)]. Pinhole and x-ray microscope images are shown along with inferred calibration measurements of the CID cameras. Currently, the same cameras are being used to obtain x-ray spectra in a TIM-based spectrometer, extending their use to all time-integrated imaging and spectroscopic x-ray instruments used on OMEGA. Additional highlights of the research presented in this issue are: (1) V. A. Smalyuk, B. Yaakobi, F. J. Marshall, and D. D. Meyerhofer investigate the spatial structure of the temperature and density of target-shell plasmas at peak compression (stagnation). This is accomplished by examining the energy dependence of the x-ray emission using narrow-band x-ray filters and the known absorption properties of the shell dopant (Ti). (2) F. Sequin, C. K. Ll, D. G. Hicks, J. A. Frenje, K. M. Green, R. D. Petrasso, J. M. Soures, V. Yu. Glebov, C. Stoeckl, P. B. Radha, D. D. Meyerhofer, S. Roberts, C. Sorce, T. C. Sangster, M. D. Cable, S. Padalino, and K. Fletcher detail the physics and instrumentation used to obtain and interpret secondary D-{sup 3}He proton spectra from current gas-filled-target and future cryogenic-target experiments. Through a novel extension of existing charged-particle detection techniques with track detectors, the authors demonstrate the ability to obtain secondary proton spectra with increased sensitivity. (3) M. Guardelben, L. Ning, N. Jain, D. Battaglia, and K. Marshall compare the utility of a novel liquid-crystal-based, point-diffraction interferometer (LCPDI) with the commercial standard phase-shifting interferometer and conclude that the LCPDI is a viable low-cost alternative. (4) A. B. Shorey, S. D. Jacobs, W. I. Kordonski, and R

  2. LLE Review 83, Quarterly Report

    International Nuclear Information System (INIS)

    2000-01-01

    This volume of the LLE Review, covering April-June 2000, features an article by F. J. Marshall, T. Ohki, D. McInnis, Z. Ninkov, and J. Carbone, who detail the conversion of the OMEGA time-integrated x-ray diagnostics to electronic readout using direct-detection x-ray cameras [charge-injection devices (CID's)]. Pinhole and x-ray microscope images are shown along with inferred calibration measurements of the CID cameras. Currently, the same cameras are being used to obtain x-ray spectra in a TIM-based spectrometer, extending their use to all time-integrated imaging and spectroscopic x-ray instruments used on OMEGA. Additional highlights of the research presented in this issue are: (1) V. A. Smalyuk, B. Yaakobi, F. J. Marshall, and D. D. Meyerhofer investigate the spatial structure of the temperature and density of target-shell plasmas at peak compression (stagnation). This is accomplished by examining the energy dependence of the x-ray emission using narrow-band x-ray filters and the known absorption properties of the shell dopant (Ti). (2) F. Sequin, C. K. Ll, D. G. Hicks, J. A. Frenje, K. M. Green, R. D. Petrasso, J. M. Soures, V. Yu. Glebov, C. Stoeckl, P. B. Radha, D. D. Meyerhofer, S. Roberts, C. Sorce, T. C. Sangster, M. D. Cable, S. Padalino, and K. Fletcher detail the physics and instrumentation used to obtain and interpret secondary D- 3 He proton spectra from current gas-filled-target and future cryogenic-target experiments. Through a novel extension of existing charged-particle detection techniques with track detectors, the authors demonstrate the ability to obtain secondary proton spectra with increased sensitivity. (3) M. Guardelben, L. Ning, N. Jain, D. Battaglia, and K. Marshall compare the utility of a novel liquid-crystal-based, point-diffraction interferometer (LCPDI) with the commercial standard phase-shifting interferometer and conclude that the LCPDI is a viable low-cost alternative. (4) A. B. Shorey, S. D. Jacobs, W. I. Kordonski, and R. F. Gans

  3. Inland Ertebølle culture

    DEFF Research Database (Denmark)

    Philippsen, Bente

    The Ertebølle culture is a late-Mesolithic hunter-gatherer-fisher culture in Southern Scandinavia, Northern Germany and Poland. Archaeological finds as well as scientific analyses of humans and their artefacts indicate the great importance of aquatic resources for this culture. This applies both...

  4. On Tamm's problem in the Vavilov-Cherenkov radiation theory

    International Nuclear Information System (INIS)

    Afanas'ev, G.N.; Kartavenko, V.G.; Stepanovskij, Yu.P.

    1999-01-01

    We analyze the well-known Tamm's problem treating the charge motion on a finite space interval with the velocity exceeding light velocity in medium. By comparing Tamm's approximate formulae with the exact ones we prove that the former do not properly describe Cherenkov radiation terms. We also investigate Tamm's formula cos θ T = 1/βn defining the position of the maximum of the field strengths in the Fourier representation. Numerical analysis of the Fourier components of field strengths shows that they have a well pronounced maximum at θ = θ T only for the charge motion on the sufficiently small interval. As an interval grows, many maxima appear. For the charge motion on an infinite interval there is infinite number of maxima of the same amplitude. The quantum analysis of Tamm's formula leads to the same results

  5. Gestures recognition based on wavelet and LLE

    International Nuclear Information System (INIS)

    Ai, Qingsong; Liu, Quan; Lu, Ying; Yuan, Tingting

    2013-01-01

    Wavelet analysis is a time–frequency, non-stationary method while the largest Lyapunov exponent (LLE) is used to judge the non-linear characteristic of systems. Because surface electromyography signal (SEMGS) is a complex signal that is characterized by non-stationary and non-linear properties. This paper combines wavelet coefficient and LLE together as the new feature of SEMGS. The proposed method not only reflects the non-stationary and non-linear characteristics of SEMGS, but also is suitable for its classification. Then, the BP (back propagation) neural network is employed to implement the identification of six gestures (fist clench, fist extension, wrist extension, wrist flexion, radial deviation, ulnar deviation). The experimental results indicate that based on the proposed method, the identification of these six gestures can reach an average rate of 97.71 %.

  6. LLE Review 97 (October-December 2003)

    International Nuclear Information System (INIS)

    Goncharov, V.N.

    2004-01-01

    This volume of the LLE Review, covering October-December 2003, features 'Direct-Drive Cryogenic Target Implosion Performance on OMEGA.' Layered and characterized cryogenic D2 capsules have been imploded using high-contrast pulse shapes on the 60-beam OMEGA laser at the Laboratory for Laser Energetics. These experiments measure the sensitivity of the direct-drive implosion performance to parameters such as the inner-ice-surface roughness, the adiabat of the fuel during the implosion, and the laser power balance

  7. Tuotannon layoutin suunnittelu Flinkenberg OY:lle

    OpenAIRE

    Puotiniemi, Olli

    2013-01-01

    Opinnäytetyön aiheena on layoutsuunnittelu Flinkenberg Oy:lle. Yrityksen on tarkoitus tulevaisuudessa hankkia uusi työstökone nykyisiin toimitiloihin. Siitä seurasi tarve saada uusi layoutsuunnitelma tuotantohallista vanhan tilalle. Myös vanha layout kaipasi päivitystä. Opinnäytetyössä on pyritty soveltamaan jo olemassa olevaa teoriaa ja käytäntöä layoutsuunnittelussa. Teoriaa oli tarjolla paljon, ja olikin tärkeää osata perehtyä vain olennaiseen. Siihen tässäkin tutkimuksessa on pyritty....

  8. LLE Review 120 (July-September 2009)

    Energy Technology Data Exchange (ETDEWEB)

    Edgell, D.H., editor

    2001-02-19

    This issue has the following articles: (1) The Omega Laser Facility Users Group Workshop; (2) The Effect of Condensates and Inner Coatings on the Performance of Vacuum Hohlraum Targets; (3) Zirconia-Coated-Carbonyl-Iron-Particle-Based Magnetorheological Fluid for Polishing Optical Glasses and Ceramics; (4) All-Fiber Optical Magnetic Field Sensor Based on Faraday Rotation in Highly Terbium Doped Fiber; (5) Femtosecond Optical Pump-Probe Characterization of High-Pressure-Grown Al{sub 0.86}Ga{sub 0.14}N Single Crystals; (6) LLE's Summer High School Research Program; (7) Laser Facility Report; and (8) National Laser Users Facility and External Users Programs.

  9. One-dimensional Tamm plasmons: Spatial confinement, propagation, and polarization properties

    Science.gov (United States)

    Chestnov, I. Yu.; Sedov, E. S.; Kutrovskaya, S. V.; Kucherik, A. O.; Arakelian, S. M.; Kavokin, A. V.

    2017-12-01

    Tamm plasmons are confined optical states at the interface of a metal and a dielectric Bragg mirror. Unlike conventional surface plasmons, Tamm plasmons may be directly excited by an external light source in both TE and TM polarizations. Here we consider the one-dimensional propagation of Tamm plasmons under long and narrow metallic stripes deposited on top of a semiconductor Bragg mirror. The spatial confinement of the field imposed by the stripe and its impact on the structure and energy of Tamm modes are investigated. We show that the Tamm modes are coupled to surface plasmons arising at the stripe edges. These plasmons form an interference pattern close to the bottom surface of the stripe that involves modification of both the energy and loss rate for the Tamm mode. This phenomenon is pronounced only in the case of TE polarization of the Tamm mode. These findings pave the way to application of laterally confined Tamm plasmons in optical integrated circuits as well as to engineering potential traps for both Tamm modes and hybrid modes of Tamm plasmons and exciton polaritons with meV depth.

  10. LLE (Laboratory for Laser Energetics) review

    Energy Technology Data Exchange (ETDEWEB)

    Kumpan, S.A. (ed.)

    1990-01-01

    This volume of the LLE Review, covering the period July--September 1990, contains articles in two main sections: the OMEGA Upgrade and Advanced Technology Developments. The first article in Section 1 describes the changes in the overall system design of the 60-beam OMEGA Upgrade since the release of the OMEGA Upgrade Preliminary Design Document in October 1989. It is followed by an article that presents results of an investigation into stimulated rotational Raman scattering as it relates to the propagation of high-fluence ultraviolet laser beams in the OMEGA Upgrade. The third article is a report on the energy-transport measurements made on the multisegmented amplifier (MSA), built as a prototype amplifier for the original OMEGA Upgrade system configuration. The final article in Section 1 describes the design of the 20-cm-clear-aperture, single-segmented amplifier (SSA), which will be the final amplifier in the current OMEGA Upgrade system configuration. Section 2 presents the results to date of an intensive in-house effort at LLE to develop the various optical coatings required for the OMEGA Upgrade.

  11. LLE Review 117 (October-December 2008)

    Energy Technology Data Exchange (ETDEWEB)

    Bittle, W., editor

    2009-05-28

    This volume of the LLE Review, covering October-December 2008, features 'Demonstration of the Shock-Timing Technique for Ignition Targets at the National Ignition Facility' by T. R. Boehly, V. N. Goncharov, S. X. Hu, J. A. Marozas, T. C. Sangster, D. D. Meyerhofer (LLE), D. Munro, P. M. Celliers, D. G. Hicks, G. W. Collins, H. F. Robey, O. L. Landen (LLNL), and R. E. Olson (SNL). In this article (p. 1) the authors report on a technique to measure the velocity and timing of shock waves in a capsule contained within hohlraum targets. This technique is critical for optimizing the drive profiles for high-performance inertial-confinement-fusion capsules, which are compressed by multiple precisely timed shock waves. The shock-timing technique was demonstrated on OMEGA using surrogate hohlraum targets heated to 180 eV and fitted with a re-entrant cone and quartz window to facilitate velocity measurements using velocity interferometry. Cryogenic experiments using targets filled with liquid deuterium further demonstrated the entire timing technique in a hohlraum environment. Direct-drive cryogenic targets with multiple spherical shocks were also used to validate this technique, including convergence effects at relevant pressures (velocities) and sizes. These results provide confidence that shock velocity and timing can be measured in NIF ignition targets, thereby optimizing these critical parameters.

  12. Au tööle / Andreas Trossek, Margus Tamm

    Index Scriptorium Estoniae

    Trossek, Andreas, 1980-

    2009-01-01

    Vastuseks Mari Laanemetsa ja Indrek Sirkli artiklike "Elu on läinud paremaks, elu on läinud lõbusamaks ...?" (Sirp, 2009, 31. 07, lk. 18-19) Eesti kunsti ja visuaalkultuuri ajakirja "Kunst.ee" 2009. aasta nr. 1-2 sisu ja kujunduse kohta. Ajakirja uus toimetus: Andreas Trossek - peatoimetaja, Heie Treier, Ave Randviir, kujundaja Margus Tamm

  13. President istutas Torisse tamme / Eno-Gerrit Link

    Index Scriptorium Estoniae

    Link, Eno-Gerrit

    2007-01-01

    President Toomas Hendrik Ilves osales Toris Eesti sõjameeste mälestuskirikus traditsioonilisel vabadusvõitluse mälestusele pühendatud jumalateenistusel ja istutas kiriku kõrvale prominentide parki tamme. Varem on sellesse parki tammepuu istutanud president Arnold Rüütel, 20. augusti klubi, endine kaitseväe juhataja Aleksander Einseln ja peapiiskop Andres Põder

  14. Han er her endnu

    DEFF Research Database (Denmark)

    Bonde, Lisbeth

    2012-01-01

    Interview med den kinesiske aktivist og billedkunstner Ai Weiwei, der sad fængslet i 81 dage i 2011. Hans pas er stadig (i februar 2014) inddraget af myndighederne, så han kan ikke forlade landet, selv om han har betalt en bøde på 13 mio. kr. for ”skatteunddragelse”. Både i sin kunst og i sine...... mange aktioner retter han en hård kritik af det korrupte kinesiske styre, som træder menneskerettighederne under fode. Men uretfærdighedsfølelsen har sin pris i et totalitært og topstyret samfund. Ligegyldigt, hvor mange vigtige udstillinger han har i udlandet, må han blive hjemme og styre aktiviteterne...... via cyberspace. I interviewet fortæller Ai Weiwei om de personlige omkostninger, som hans kamp mod systemet indebærer....

  15. Development of a radioimmunoassay for 'Tamm-Horsfall-like' glycoprotein in serum and cerebrospinal fluid

    International Nuclear Information System (INIS)

    Hartmann, L.; Bringuier, A.-F.; Schuller, E.

    1983-01-01

    Affinity chromatography purification was combined with a radioimmunoassay for 'Tamm-Horsfall-like' glycoprotein. This enabled serum comcentrations to be established and to demonstrate its presence in cerebrospinal fluid for the first time. This assay method used in different circumstances suggests a multifocal synthesis. Nevertheless, urinary Tamm-Horsfall glycoprotein so far must be distinguished from the serum or cerebrospinal fluid Tamm-Horsfall-like glycoprotein. (Auth.)

  16. LLE Review 116 (July-September 2008)

    International Nuclear Information System (INIS)

    Marozas, J.A.

    2010-01-01

    This issue has the following articles: (1) Optimizing Electron-Positron Pair Production on kJ-Class High-Intensity Lasers for the Purpose of Pair-Plasma Creation; (2) Neutron Yield Study of Direct-Drive, Low-Adiabat Cryogenic D2 Implosions on OMEGA; (3) Al 1s-2p Absorption Spectroscopy of Shock-Wave Heating and Compression in Laser-Driven Planar Foil; (4) A Measurable Lawson Criterion and Hydro-Equivalent Curves for Inertial Confinement Fusion; (5) Pulsed-THz Characterization of Hg-Based, High-Temperature Superconductors; (6) LLE's Summer High School Research Program; (7) FY08 Laser Facility Report; and (8) National Laser Users Facility and External Users Programs.

  17. LLE Review 116 (July-September 2008)

    Energy Technology Data Exchange (ETDEWEB)

    Marozas, J.A., editor

    2010-03-12

    This issue has the following articles: (1) Optimizing Electron-Positron Pair Production on kJ-Class High-Intensity Lasers for the Purpose of Pair-Plasma Creation; (2) Neutron Yield Study of Direct-Drive, Low-Adiabat Cryogenic D2 Implosions on OMEGA; (3) Al 1s-2p Absorption Spectroscopy of Shock-Wave Heating and Compression in Laser-Driven Planar Foil; (4) A Measurable Lawson Criterion and Hydro-Equivalent Curves for Inertial Confinement Fusion; (5) Pulsed-THz Characterization of Hg-Based, High-Temperature Superconductors; (6) LLE's Summer High School Research Program; (7) FY08 Laser Facility Report; and (8) National Laser Users Facility and External Users Programs.

  18. LLE 2008 annual report, October 2007 - September 2008

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-01-31

    The research program at the University of Rochester’s Laboratory for Laser Energetics (LLE) focuses on inertial confinement fusion (ICF) research supporting the goal of achieving ignition on the National Ignition Facility (NIF). This program includes the full use of the OMEGA EP Laser System. Within the National Ignition Campaign (NIC), LLE is the lead laboratory for the validation of the performance of cryogenic target implosions, essential to all forms of ICF ignition. LLE has taken responsibility for a number of critical elements within the Integrated Experimental Teams (IET’s) supporting the demonstration of indirect-drive ignition on the NIF and is the lead laboratory for the validation of the polardrive approach to ignition on the NIF. LLE is also developing, testing, and building a number of diagnostics to be deployed on the NIF for the NIC.

  19. The LLE, pattern formation and a novel coherent source

    Science.gov (United States)

    Castelli, Fabrizio; Brambilla, Massimo; Gatti, Alessandra; Prati, Franco; Lugiato, Luigi A.

    2017-04-01

    The LLE was introduced in order to provide a paradigmatic model for spontaneous spatial pattern formation in the field of nonlinear optics. In the first part of this paper we describe in details its historical evolution. We underline, first of all, that the multimode instability of optical bistability represents an important precursor of the LLE. Next, we illustrate how the original LLE was conceived in order to describe pattern formation in the planes transverse with respect to the longitudinal direction of propagation of light in the nonlinear medium contained in the optical cavity. We emphasize, in particular, the crucial role of the low transmission limit (also called mean field limit or uniform field limit in the literature) in determining the simplicity of the equation. In discussing transverse pattern formation in the LLE, we underline incidentally the presence of very important quantum aspects related to squeezing of quantum fluctuations and to quantum imaging. We consider not only the case of global patterns but also localized structures (cavity solitons and their control). Then we turn to the temporal/longitudinal version of the LLE, formulated by Haelterman et al. [H. Haelterman, S. Trillo, S. Wabnitz, Opt. Commun. 91, 401 (1992)], and to its equivalence with the transverse LLE in 1D, discussing especially the phenomenon of temporal cavity solitons, their experimental observation and their control. Finally for the first part we turn to the very recent topic of broadband frequency combs, observed in a versatile multiwavelength coherent source (driven Kerr microcavity), which is raising a lot of interest and of research activities because of its very favourable physical characteristics, which support quite promising applicative perspectives. Kerr microcavities realize in an ideal manner the basic assumptions of the LLE, and the spontaneous formation of travelling patterns along the microcavity is the crucial mechanism which creates the combs and governs

  20. Taloussuunnitelma aloittavalle yksityisyrittäjälle

    OpenAIRE

    Suominen, Sari

    2011-01-01

    Opinnäytetyö tehtiin toimeksiantona lokakuussa 2010 toimintansa aloittaneelle, asianatuntija-palveluita tuottavalle yksityisyrittäjälle. Toimeksiantajan palveluvalikoimaan kuuluu business coaching, konsultointi ja projektinhallintakoulutus. Opinnäytetyön tavoitteena oli antaa yrittäjälle valmiuksia kannattavaan yritystoimintaan muun muassa hinnoitteluopin ja budjetoinnin avulla. Toinen tutkimuskohde oli selvittää, miten verotus ja sosiaaliturva muuttuvat, kun siirtyy palkan-saajasta yksityisy...

  1. Hans Raj Wason

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. Hans Raj Wason. Articles written in Journal of Earth System Science. Volume 125 Issue 4 June 2016 pp 855-871. Identification of seismically susceptible areas in western Himalaya using pattern recognition · Mridula Amita Sinvhal Hans Raj Wason · More Details Abstract ...

  2. Studeren met Hans Rosenberg

    NARCIS (Netherlands)

    Rutten, R.J.

    2001-01-01

    Hoe was het om in de jaren zestig te studeren? Laat ik een terugblik ophangen aan een studiemakker, Hans Rosenberg. We vormden samen de sterrekundejaar- gang 1961. Hans studeerde af in 1966 met hoofdvak wiskunde, promoveerde op radiostralingsprocessen in de zonnecorona in 1973, verliet de

  3. Hans Raj Negi

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Hans Raj Negi. Articles written in Resonance – Journal of Science Education. Volume 8 Issue 1 January 2003 pp 51-58 General Article. Lichens: A Valuable Bioresource for Environmental Monitoring and Sustainable Development · Hans Raj Negi · More Details ...

  4. Henriku kroonika pole veel ammendatud / Marek Tamm, Linda Kaljundi ; intervjueerinud Valle-Sten Maiste

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2011-01-01

    Intervjuu Marek Tamme ja Linda Kaljundiga nende poolt toimetatud artiklikogumikust: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia / edited by Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham ; Burlington : Ashgate, 2011

  5. Landbrugets trædemølle

    DEFF Research Database (Denmark)

    Hansen, Henning Otte

    2016-01-01

    Teorien om landbrugets trædemølle siger, at teknologi medfører stigende produktivitet, stigende udbud og dermed faldende priser. Dermed øges behovet for ny teknologi. Det vedvarende teknologipres gavner de innovative landmænd, mens de mere afventende landmænd kun oplever de negative virkninger i...... form af prisfald. I denne artikel beskrives nærmere de enkelte elementer i trædemøllen. Samtidig vurderes trædemøllens betydning og mulige påvirkning. Det konkluderes, at trædemøllen, dens forudsætninger og afledte virkninger stadig er fuldt gældende. Det er ikke muligt for et enkelt land eller region...... af bremse trædemøllen på lang sigt. På lokalt plan kan man løse nogle sociale og økonomiske problemer skabt af trædemøllen gennem nemmere afvandring....

  6. Optical Tamm states in one-dimensional magnetophotonic structures.

    Science.gov (United States)

    Goto, T; Dorofeenko, A V; Merzlikin, A M; Baryshev, A V; Vinogradov, A P; Inoue, M; Lisyansky, A A; Granovsky, A B

    2008-09-12

    We demonstrate the existence of a spectrally narrow localized surface state, the so-called optical Tamm state, at the interface between one-dimensional magnetophotonic and nonmagnetic photonic crystals. The state is spectrally located inside the photonic band gaps of each of the photonic crystals comprising this magnetophotonic structure. This state is associated with a sharp transmission peak through the sample and is responsible for the substantial enhancement of the Faraday rotation for the corresponding wavelength. The experimental results are in excellent agreement with the theoretical predictions.

  7. LLE Review 114 (January-March 2008)

    International Nuclear Information System (INIS)

    Zuegel, J.D.

    2008-01-01

    This volume of the LLE Review, covering January-March 2008, features 'Cryogenic Targets: Current Status and Future Development', by D. R. Harding, D. H. Edgell, M. D. Wittman, L. M. Elasky, S. J. Verbridge, A. J. Weaver, L. D. Lund, W. Seka, W. T. Shmayda, R. T. Janezic, M. J. Shoup III, M. Moore, R. Junquist, and A. V. Okishev. In this article (p. 57), the authors report on the status of layering cryogenic DT and D 2 targets at LLE for inertial confinement fusion (ICF) targets. This critical effort achieves the important milestone of routinely providing cryogenic DT targets that meet the 1.0-(micro)m (rms) OMEGA ice-quality-surface specification. The best D 2 -ice layers produced so far (rms roughness of 1.1 (micro)m) are approaching the quality typically achieved in DT targets. Efforts to improve the consistency of this process are reported along with investigations supporting the National Ignition Campaign studying issues relevant to indirect-drive and direct-drive cryogenic targets. Additional highlights of recent research presented in this issue include the following: (1) an improved laser speckle smoothing scheme that augments the current NIF 1-D SSD system by using multiple-FM modulators (MultiFM 1-D SSD) (p. 73). With a judicious choice of modulator frequencies, MultiFM 1-D SSD smoothes resonances produced at the higher spatial frequencies and can attain similar or even faster smoothing rates compared to the baseline NIF 2-D SSD system. DRACO simulations have shown that MultiFM 1-D SSD beam smoothing is sufficient for the direct-drive-ignition targets and pulse shapes analyzed thus far, and may even allow reducing the bandwidth enough to eliminate the need for dual-tripler frequency conversion on the NIF. (2) describes a time-gated, monoenergetic proton radiography that provides unique measurements of implosion dynamics of spherical targets in direct-drive inertial confinement fusion (ICF) (p. 81). Radiographs obtained at different implosion times, from

  8. Hans Christian Andersen

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen

    2007-01-01

    The Danish author, Hans Christian Andersen, living in the 1800s expressed through his fairy tales and other stories an enthusiasm for the technological breakthroughs in that century with trains, etc. But he also showed great concern for what the natural science did to people by narrowing their mind...

  9. LLE Review. Quarterly report, April-June 1985

    International Nuclear Information System (INIS)

    Skupsky, S.

    1985-01-01

    This volume of the LLE Review contains articles on the fully UV-converted OMEGA laser system, mass-ablation rate experiments, reactor-size target designs, plasma processes in the target corona, degradation in optical performance of dielectric thin films, and the National Laser Users Facility activities for April-June 1985. 65 refs., 35 figs

  10. LLE 2004 annual report, October 2003-September 2004

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2005-01-01

    This report summarizes research at the Laboratory for Laser Energetics (LLE) conducted during the year, operation of the National Laser Users’ Facility (NLUF), a status report of the new OMEGA Extended Performance (EP) laser project, and programs concerning the education of high school, undergraduate, and graduate students during the year.

  11. Noblessneri Loomemaja = Noblessner Creative house / Rasmus Tamme, Jaanus Saarepera, Eero Jürgenson, Andres Jomp

    Index Scriptorium Estoniae

    2015-01-01

    Noblessneri Loomemaja Tallinnas Tööstuse 48/Peetri 11, valminud 2014. Arhitektid Rasmus Tamme, Jaanus Saarepera (ARS Projekt), sisearhitektid Eero Jürgenson, Andres Jomp (ARS Projekt). 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

  12. Reports of the working groups / Eino Tamm, Sahlin Michael, Valve Kirsipuu...[jt.

    Index Scriptorium Estoniae

    1999-01-01

    Töögruppide "EU enlargement and relevant institutional reforms" (juhatajad Eino Tamm, Michael Sahlin) ja "Maintaining of competitiveness of Estonia and other candidate countries" (juhatajad Valve Kirsipuu, Terry Calbom) tööst. Autor: Reformierakond

  13. F. Herve operett "Mam'zelle Nitouche" majandusgümnaasiumi laval / Ulvi Tamm

    Index Scriptorium Estoniae

    Tamm, Ulvi

    2003-01-01

    Lauluõpetaja Ulvi Tamme ja tema õpilaste lavastatud operetist "Mam'zelle Nitouche". Esiettekanne 18. veebr. Pärnu majandusgümnaasiumi aulas ja 14. märtsil Tallinnas Salme Kultuurikeskuses vabariiklikul muusikateatrite festivalil

  14. The Hans Tausen drill

    DEFF Research Database (Denmark)

    Johnsen, Sigfus Johann; Dahl-Jensen, Dorthe; Steffensen, Jørgen Peder

    2007-01-01

    In the mid-1990s, excellent results from the GRIP and GISP2 deep drilling projects in Greenland opened up funding for continued ice-coring efforts in Antarctica (EPICA) and Greenland (NorthGRIP). The Glaciology Group of the Niels Bohr Institute, University of Copenhagen, was assigned the task...... of providing drilling capability for these projects, as it had done for the GRIP project. The group decided to further simplify existing deep drill designs for better reliability and ease of handling. The drill design decided upon was successfully tested on Hans Tausen Ice Cap, Peary Land, Greenland, in 1995....... The 5.0 m long Hans Tausen (HT) drill was a prototype for the ~11 m long EPICA and NorthGRIP versions of the drill which were mechanically identical to the HT drill except for a much longer core barrel and chips chamber. These drills could deliver up to 4 m long ice cores after some design improvements...

  15. Tribute to Hans Sann

    CERN Multimedia

    2003-01-01

    1945-2003 Hans Sann, an internationally recognized scientist, beloved colleague and friend, died in a tragic car accident, on May 27th, on one of his many travels to CERN. Employed at GSI, in Darmstadt, since 1979, Hans Sann devoted most of his scientific career to the development of large size gas detectors for nuclear and high-energy physics experiments at GSI, CERN and Berkeley. One of his main achievements, among many others, was the famous MUSIC detector, on which several projects at GSI, Berkeley and other research Institutes were based. The innovative results obtained in the study of the fluid-gas transition in nuclear matter would not have been possible without his contribution and the application of the MUSIC detector. A member of the ALICE Collaboration since 1996, Hans was leading two main ALICE sub-programmes, the development of the gas system and the cooling system for the TPC detector. In addition, he was involved in the development of a new technological concept for the resistor chain of the ...

  16. Kultuuri on üha rohkem, mõtestamist aina vähem / Marek Tamm ; intervjueerinud Heili Sibrits

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2017-01-01

    Intervjuu Marek Tammega kuluurist, kultuuri uurimisest ja kultuuri mõistest. Tallinna Ülikooli kirjastuselt ilmunud kogumikust "Kuidas uurida kultuuri? Kultuuriteaduste metodoloogia", koostajaks kultuuriajaloo professor Marek Tamm

  17. In Memoriam: Hans Bethe

    Science.gov (United States)

    Garwin, Richard L.; Von Hippel, Frank

    Hans Bethe, who died on March 6 at the age of 98, was exemplary as a scientist; a citizen-advocate seeking to stem the arms race; and an individual of warmth, generosity, tenacity, and modest habits. Bethe made major contributions to several areas of physics during his academic career. He earned a Nobel Prize in 1967 for his research into how the sun generates its energy by converting hydrogen to helium using carbon as a nuclear catalyst. A few years later, he made central contributions to the secret US World War II nuclear-weapon development programs (the "Manhattan Project").

  18. Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization

    Directory of Open Access Journals (Sweden)

    Carvalho M.

    2002-01-01

    Full Text Available One of the defenses against nephrolithiasis is provided by macromolecules that modulate the nucleation, growth, aggregation and retention of crystals in the kidneys. The aim of the present study was to determine the behavior of two of these proteins, Tamm-Horsfall and uromodulin, in calcium oxalate crystallization in vitro. We studied a group of 10 male stone formers who had formed at least one kidney stone composed of calcium oxalate. They were classified as having idiopathic nephrolithiasis and had no well-known metabolic risk factors involved in kidney stone pathogenesis. Ten normal men were used as controls, as was a group consisting of five normal women and another consisting of five pregnant women. Crystallization was induced by a fixed supersaturation of calcium oxalate and measured with a Coulter Counter. All findings were confirmed by light and scanning electron microscopy. The number of particulate material deposited from patients with Tamm-Horsfall protein was higher than that of the controls (P<0.001. However, Tamm-Horsfall protein decreased the particle diameter of the stone formers when analyzed by the mode of the volume distribution curve (P<0.002 (5.64 ± 0.55 µm compared to 11.41 ± 0.48 µm of uromodulin; 15.94 ± 3.93 µm and 12.45 ± 0.97 µm of normal men Tamm-Horsfall protein and uromodulin, respectively; 8.17 ± 1.57 µm and 9.82 ± 0.95 µm of normal women Tamm-Horsfall protein and uromodulin, respectively; 12.17 ± 1.41 µm and 12.99 ± 0.51 µm of pregnant Tamm-Horsfall protein and uromodulin, respectively. Uromodulin produced fewer particles than Tamm-Horsfall protein in all groups. Nonetheless, the total volume of the crystals produced by uromodulin was higher than that produced by Tamm-Horsfall protein. Our results indicate a different effect of Tamm-Horsfall protein and uromodulin. This dual behavior suggests different functions. Tamm-Horsfall protein may act on nucleation and inhibit crystal aggregation, while

  19. LLE review. Volume 65. Quarterly report, October--December 1995

    Energy Technology Data Exchange (ETDEWEB)

    Boehly, T.R. [ed.

    1996-06-01

    This volume of the LLE Review, covering the period October-December 1995, contains a description of the generation and characterization of continuous, deep-surface-relief phase plates that are more efficient and versatile than previous designs. The LLE program plan has scheduled a number of enhancements to OMEGA`s performance and uniformity, the first of which is the implementation of these new distributed phase plates. Other articles in this volume include the discussion of an x-ray diagnostic method to measure shell-fuel mixing, the theoretical analysis of ablation-front stability, a description of a major subsystem in the OMEGA control system software, a study of the population inversions in intensely pumped Nd:YLF, and a description of a new ultrafast laser system and its uses.

  20. LLE 2007 Annual Report, October 2006 - September 2007

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-31

    The laser-fusion research program at the University of Rochester’s Laboratory for Laser Energetics (LLE) is focused on the National Nuclear Security Administration’s (NNSA’s) Campaign-10 inertial confinement fusion (ICF) ignition and experimental support technology, operation of facilities (OMEGA), and the construction of OMEGA EP -- a high energy petawatt laser system. While LLE is the lead laboratory for research into the direct-drive approach to ICF ignition, it also takes a lead role in certain indirect-drive tasks within the National Ignition Campaign. During this past year progress in the laser-fusion research program was made in three principal areas: OMEGA direct drive and indirect-drive experiments and targets; development of diagnostics for experiments on OMEGA, OMEGA EP, and the National Ignition Facility (NIF); and theoretical analysis and design efforts aimed at improving direct-drive-ignition capsule designs and advanced ignition concepts such as fast ignition and shock ignition.

  1. LLE 2010 Annual Report October 2009 - September 2010

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-01-01

    The fiscal year ending September 2010 (FY10) concluded the third year of the third five-year renewal of Cooperative Agreement DE-FC52-08NA28302 with the U.S. Department of Energy (DOE). This annual report summarizes progress in inertial fusion research at the Laboratory for Laser Energetics (LLE) during the past fiscal year including work on the National Ignition Campaign (NIC). It also reports on LLE's progress on laboratory basic science research; laser, optical materials, and advanced technology development; operation of OMEGA and OMEGA EP for the NIC and high-energy density (HED) campaigns, the National Laser Users Facility (NLUF), and for other external users; and programs focusing on the education of high school, undergraduate, and graduate students during the year.

  2. Optical Tamm states in one-dimensional superconducting photonic crystal

    Energy Technology Data Exchange (ETDEWEB)

    El Abouti, O. [LPMR, Département de Physique, Faculté des Sciences, Université Mohammed 1, 60000 Oujda (Morocco); El Boudouti, E. H. [LPMR, Département de Physique, Faculté des Sciences, Université Mohammed 1, 60000 Oujda (Morocco); IEMN, UMR-CNRS 8520, UFR de Physique, Université de Lille 1, 59655 Villeneuve d' Ascq (France); El Hassouani, Y. [ESIM, Département de Physique, Faculté des Sciences et Techniques, Université Moulay Ismail, Boutalamine BP 509, 52000 Errachidia (Morocco); Noual, A. [LPMR, Département de Physique, Faculté des Sciences, Université Mohammed 1, 60000 Oujda (Morocco); Ecole Normale Supérieur de Tétouan, Université Abdelmalek Essaadi, Tétouan (Morocco); Djafari-Rouhani, B. [IEMN, UMR-CNRS 8520, UFR de Physique, Université de Lille 1, 59655 Villeneuve d' Ascq (France)

    2016-08-15

    In this study, we investigate localized and resonant optical waves associated with a semi-infinite superlattice made out of superconductor-dielectric bilayers and terminated with a cap layer. Both transverse electric and transverse magnetic waves are considered. These surface modes are analogous to the so-called Tamm states associated with electronic states found at the surface of materials. The surface guided modes induced by the cap layer strongly depend on whether the superlattice ends with a superconductor or a dielectric layer, the thickness of the surface layer, the temperature of the superconductor layer as well as on the polarization of the waves. Different kinds of surface modes are found and their properties examined. These structures can be used to realize the highly sensitive photonic crystal sensors.

  3. An improved radioimmunoassay for urinary Tamm-Horsfall glycoprotein

    International Nuclear Information System (INIS)

    Dawnay, A.B. St. J.; Thornley, C.; Cattell, W.R.

    1982-01-01

    A rapid specific radioimmunoassay has been used to measure Tamm-Horsfall glycoprotein (TH glycoprotein) in urine, and the method described. The apparent concentration increased with increasing dilution of urine in water, reaching a plateau at 1 in 20. This increase was greater the higher the osmolality and TH glycoprotein concentration and the lower the pH of the original sample. The apparent concentration of TH glycoprotein in neat or diluted urine was not affected by freezing or by storage at 4 0 C or room temperature for at least 2 days. A physiological range for the urinary excretion rate was established as 22-56 mg/24h, (considerably higher than the amount present in serum) based on samples from 29 individuals with normal renal function, as defined by their creatinine clearance. There was no significant correlation between serum concentrations of TH glycoprotein and its urinary excretion rate, nor between urinary excretion rate and creatinine clearance. (author)

  4. Audiovisuaalinen koulutuspaketti ensihoitohenkilöstölle peruselintoimintojen mittaamisesta

    OpenAIRE

    Pelkonen, Juha

    2013-01-01

    Tiivistelmä Tämä opinnäyteyö oli kehittämistyö, jonka tarkoituksena oli laatia audiovisuaalinen koulutuspaketti peruselintoimintojen mittaamisesta Pohjois-Savon pelastuslaitokselle ensihoitohenkilöstölle. Kehittämistyön tavoitteena oli vahvistaa pelastuslaitoksen ensihoitohenkilöstön osaamista peruselintoimintojen mittaamisessa. Koulutuspaketin tavoitteena oli antaa vaihtoehtoinen tapa kerrata jo vanhaa opittua sekä motivoida uuteen oppimiseen audiovisuaalisesti demonstraati...

  5. LLE Review Quarterly Report October - December 2011. Volume 129

    Energy Technology Data Exchange (ETDEWEB)

    Shvydky, Alex [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2011-12-01

    This volume of LLE Review, covering October–December 2011, features “Crossed-Beam Energy Transfer in Direct-Drive Implosions” by I. V. Igumenshchev, W. Seka, D. H. Edgell, D. T. Michel, D. H. Froula, R. S. Craxton, R. Follett, J. H. Kelly, T. Z. Kosc, J. F. Myatt, T. C. Sangster, A. Shvydky, S. Skupsky, and C. Stoeckl (LLE); V. N. Goncharov and A. V. Maximov (LLE and Department of Mechanical Engineering, U. of Rochester); L. Divol and P. Michel (LLNL); and R. L. McCrory and D. D. Meyerhofer (LLE and Departments of Mechanical Engineering and Physics, U. of Rochester). In this article (p. 1), direct-drive–implosion experiments on the OMEGA laser [T. R. Boehly et al., Opt. Commun. 133, 495 (1995)] have shown discrepancies between simulations of the scattered (non-absorbed) light levels and measured ones that indicates the presence of a mechanism that reduces laser coupling efficiency by 10% to 20%. The authors attribute this degradation in laser coupling to crossed-beam energy transfer (CBET)— which is electromagnetically seeded—low-gain stimulated Brillouin scattering. CBET scatters energy from the central portion of the incoming light beam to outgoing light, reducing the laser absorption and hydrodynamic efficiency of implosions. One-dimensional hydrodynamic simulations including CBET show good agreement with all observables in implosion experiments on OMEGA. Three strategies to mitigate CBET and improve laser coupling are considered: the use of narrow beams, multicolor lasers, and higher-Z ablators. Experiments on OMEGA using narrow beams have demonstrated improvements in implosion performance.

  6. Khazanah: Hans Kelsen

    Directory of Open Access Journals (Sweden)

    Atip Latipulhayat

    2014-04-01

    Full Text Available Hans Kelsen adalah seorang pemikir hukum dunia yang buah pemikirannya bukan saja diperbincangkan di berbagai belahan bumi, tapi juga menjadi salah satu pemikir hukum garda depan (avant garde pada zamannya, bahkan mungkin sampai sekarang. Roscoe Pound yang juga seorang filosof hukum kenamaan memberikan testimoninya sebagai berikut: “...Kelsen was unquestionably the leading jurist of the time. It is said that if the mark of the genius is that he creates a cosmos out of chaos, then Kelsen has evidently earned that title”. Pengakuan Roscoe Pound tentunya bukan tanpa dasar atau sekedar basa-basi, melainkan sebuah testimoni objektif dengan memperhatikan warisan pemikirannya yang tersebar dalam beratus-ratus karya ilmiah yang masih memiliki pengaruh penting sampai saat ini.

  7. Sisearhitektid Väino Tamm ja Vello Asi. Näitusekataloog = Interior architects Väino Tamm and Vello Asi. Exhibition catalogue

    Index Scriptorium Estoniae

    2008-01-01

    Näitusekataloogi "Tamm ja Asi" autor ja koostaja Karen Jagodin ning kujundaja Tiit Jürna pälvisid Eesti Sisearhitektide Liidu 2007. a. publitsistika preemia. Enamik raamatus publitseeritud fotodest pärineb fotograaf Rein Vainküla kogust. K. Jagodinist ja T. Jürnast, nende fotod

  8. [Kari Tarkiainen, Ülle Tarkiainen. Provinsen bortom havet : Estlands svenska historia 1561-1710; Kari Tarkiainen, Ülle Tarkiainen. Meretagune maa : Rootsi aeg Eestis 1561-1710] / Pärtel Piirimäe

    Index Scriptorium Estoniae

    Piirimäe, Pärtel, 1972-

    2015-01-01

    Arvustus: Tarkiainen Kari, Tarkiainen Ülle. Provinsen bortom havet : Estlands svenska historia 1561-1710 Verlag Atlantis. Stockholm 2013; Tarkiainen, Kari, Tarkiainen, Ülle. Meretagune maa : Rootsi aeg Eestis 1561-1710. verlag Varrak Tallinn 2014

  9. LLE 1997. Annual report, October 1996-September 1997

    International Nuclear Information System (INIS)

    1998-01-01

    The fiscal year ending September 1997 (FY97) concluded the fifth year of the cooperative agreement (DE-FC03-92SF19460) with the U.S. Department of Energy (DOE). This report summarizes research at the Laboratory for Laser Energetics (LLE) and is the final report for the first five years of the cooperative agreement. In September 1997, the cooperative agreement was renewed for an additional five years. We summarize our research during FY97, the operation of the National Laser Users' Facility (NLUF), and the education of high school, undergraduate, and graduate students in LLE programs. A general introduction to LLE's experimental physics program and a report on recent results are found on pp. 161-167. This article includes a useful summary of the system's operational capabilities and system parameters after three years of operation. Direct-drive inertial confinement fusion requires precise drive uniformity, the control of hydrodynamic instabilities during the implosion of the fusion target, and accurate target fabrication and characterization. The article summarizes a wide variety of experiments relating to direct-drive laser fusion, from high-yield implosion experiments to planar and spherical Rayleigh-Taylor experiments, laser-imprinting experiments, and laser-plasma interaction experiments. A detailed analysis of the equation of motion for an electron in a plane wave is presented beginning on p. 24. A guiding center model is postulated and compared to numerical simulation of the actual particle motion. The formula is also verified analytically using the method of multiple scales. Work continues on this formalism to study the effects of the pondermotive force on laser-plasma interactions. A theoretical calculation of the dephasing time of an electron accelerated by a laser pulse is found on pp. 92-100. The trajectory of a charged particle, determined analytically for various pulse shapes, is then used to determine the dephasing time of an accelerated particle

  10. LLE 1997. Annual report, October 1996--September 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    The fiscal year ending September 1997 (FY97) concluded the fifth year of the cooperative agreement (DE-FC03-92SF19460) with the U.S. Department of Energy (DOE). This report summarizes research at the Laboratory for Laser Energetics (LLE) and is the final report for the first five years of the cooperative agreement. In September 1997, the cooperative agreement was renewed for an additional five years. We summarize our research during FY97, the operation of the National Laser Users` Facility (NLUF), and the education of high school, undergraduate, and graduate students in LLE programs. A general introduction to LLE`s experimental physics program and a report on recent results are found on pp. 161-167. This article includes a useful summary of the system`s operational capabilities and system parameters after three years of operation. Direct-drive inertial confinement fusion requires precise drive uniformity, the control of hydrodynamic instabilities during the implosion of the fusion target, and accurate target fabrication and characterization. The article summarizes a wide variety of experiments relating to direct-drive laser fusion, from high-yield implosion experiments to planar and spherical Rayleigh-Taylor experiments, laser-imprinting experiments, and laser-plasma interaction experiments. A detailed analysis of the equation of motion for an electron in a plane wave is presented beginning on p. 24. A guiding center model is postulated and compared to numerical simulation of the actual particle motion. The formula is also verified analytically using the method of multiple scales. Work continues on this formalism to study the effects of the pondermotive force on laser-plasma interactions. A theoretical calculation of the dephasing time of an electron accelerated by a laser pulse is found on pp. 92-100. The trajectory of a charged particle, determined analytically for various pulse shapes, is then used to determine the dephasing time of an accelerated particle.

  11. Ülle Voog sai alalõualiigese uuringuteks Eesti suurima stipendiumi / Kadri Bank

    Index Scriptorium Estoniae

    Bank, Kadri

    2007-01-01

    Tartu Ülikooli arstiteaduskonna dotsent Ülle Voog pälvis Ernst Jaaksoni mälestusfondi 200 000-kroonise stipendiumi. Ülle Voog jätkab stipendiumi toel alalõualiigeste haiguste uurimist Karolinska Instituudis Rootsis

  12. [Glass Development Laser (GDL) Facility upgrade.] LLE Review. Quarterly report, October-December 1984. Volume 21

    International Nuclear Information System (INIS)

    Kim, H.

    1984-01-01

    This volume of the LLE Review contains articles on the upgrade of the GDL (Glass Development) system, theoretical advances in the laser fusion effort, improved target fabrication capabilities, x-ray laser research, developments in the picosecond optics research of the LLE advanced technology program, and on the National Laser Users Facility activities for October-December 1984. 56 refs., 31 figs., 3 tabs

  13. LLE review. Quarterly report, April 1997--June 1997. Volume 71

    International Nuclear Information System (INIS)

    1997-01-01

    This volume of the LLE Review, covering the period April-June 1997, includes an article discussing the results from recent experiments performed on OMEGA. These experiments used a new beam-smoothing device-distributed polarization rotators-in concert with existing techniques to improve the on-target uniformity of each beam. The result of this improved radiation uniformity was a substantive reduction in imprinting-the nonuniformity caused by the laser. A novel way to study the time dependence of this imprinting is also presented in this article

  14. LLE Review Quarterly Report (April-June 1996). Volume 67

    Energy Technology Data Exchange (ETDEWEB)

    Skeldon, Mark D. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    1996-06-01

    This volume of the LLE Review, covering the period April-June 1996, contains articles detailing several nonlinear processes associated with lasers and their use, as well as an article describing the computer control systems necessary to maintain and operate a large laser system such as the 60-beam OMEGA laser. The specific topics discussed in this issue include stimulated scattering in laser plasmas, power exchange between interacting laser beams, charged particles interacting with a laser pulse, thermal equilibration of optically excited states, an overview of the laser control system software in OMEGA, and a technique for cancellation of the nonlinear phase accumulation in short-pulse lasers.

  15. LLE 2009 annual report, October 2008-September 2009

    Energy Technology Data Exchange (ETDEWEB)

    none, none

    2010-01-01

    The fiscal year ending September 2009 (FY2009) concluded the second year of the third five-year renewal of Cooperative Agreement DE-FC52-08NA28302 with the U.S. Department of Energy (DOE). This annual report summarizes progress in inertial fusion research at the Laboratory for Laser Energetics (LLE) during the past fiscal year. It also reports on LLE’s progress on laboratory basic science research; laser, optical materials, and advanced technology development; operation of OMEGA and OMEGA EP for the National Laser Users’ Facility (NLUF), and other external users; and programs focusingon the education of high school, undergraduate, and graduate students during the year.

  16. LLE Review. Quarterly report, January--March 1992: Volume 50

    Energy Technology Data Exchange (ETDEWEB)

    Keck, R.L. [ed.

    1992-09-01

    This volume of the LLE Review, covering the period January--March 1992, contains articles on the use of diffraction gratings in laser applications, and the fabrication of gratings for use in these applications. there are two articles on the use of lasers to explore fundamental physics issues and an article on the use of a solid-state diode array for x-ray imaging. Finally, the activities of the National Laser Users Facility and the GDL and OMEGA laser systems are summarized.

  17. LLE review. Quarterly report, January 1994--March 1994, Volume 58

    Energy Technology Data Exchange (ETDEWEB)

    Simon, A. [ed.

    1994-07-01

    This volume of the LLE Review, covering the period Jan - Mar 1994, contains articles on backlighting diagnostics; the effect of electron collisions on ion-acoustic waves and heat flow; using PIC code simulations for analysis of ultrashort laser pulses interacting with solid targets; creating a new instrument for characterizing thick cryogenic layers; and a description of a large-aperture ring amplifier for laser-fusion drivers. Three of these articles - backlighting diagnostics; characterizing thick cryogenic layers; and large-aperture ring amplifier - are directly related to the OMEGA Upgrade, now under construction. Separate abstracts have been prepared for articles from this report.

  18. LLE Review quarterly report, April--June 1993. Volume 55

    Energy Technology Data Exchange (ETDEWEB)

    Hutchison, R.J. [ed.

    1993-10-01

    This volume of the LLE Review, covering the period April--June 1993, contains articles on spectral features from argon-filled target implosions on OMEGA, and on the theory of an implicit difference scheme for the Fokker-Planck equation. The advanced technology section includes reports on a novel polymer liquid-crystal wave plate and a new scheme for phase conversion of the OMEGA Upgrade beams that results in greater, smoother energy deposition on fusion targets. Finally, reports on the as-designed configuration of the OMEGA newly configured glass development laser system are summarized.

  19. Nonreciprocal optical tunnelling through evanescently coupled Tamm states in magnetophotonic crystals

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Yun-Tuan [Jiangsu Univ., Zhenjiang (China). School of Computer Science and Telecommunication Engineering; Han, Ling [The Second Military Medical Univ., Shanghai (China). Dept. of Radiation Medicine; Gao, Yong-Feng [Jiangsu Univ., Zhenjiang (China). School of Mechanical Engineering

    2015-07-01

    Evanescently coupled Tamm states are achieved through two magnetophotonic crystals (MPCs) with a pair of coupling prisms. At the wavelengths of coupled Tamm states, a double of nonreciprocal optical tunnelling channels is found through the transmission spectra obtained from a developed transfer matrix method. The nonreciprocal tunnelling wavelength and the interval between two nonreciprocal channels can be adjusted depending on the width of the air gap between two MPCs or the scale invariant of a PC. The nonreciprocal tunnelling is demonstrated through electromagnetic field distribution simulations based on finite element software. Such theoretical results may provide a new method to design tunable optical isolators with a double of channels.

  20. Hans mening om hendes krop

    DEFF Research Database (Denmark)

    Scheuer, Jann

    2017-01-01

    Bidraget handler om søgninger i danske tekstkorpusser efter 'hendes' hhv. 'hans' + nominal inden for en afstand af to ord. Det er ved hjælp af søgninger i big data undersøgt hvad der knyttes til hende og ham, hvad deres ejendom er: hendes lejlighed o.l. og hvilke attributter de tilskrives hans fi...

  1. LLE Review Quarterly Report (July - September 2004). Volume 100

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, Ansgar W. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2004-09-01

    The key article in this volume of the LLE Review, covering July-September 2004, addresses "Shock Propagation in Deuterium-Tritium-Saturated Foam" by T. J. B. Collins (LLE) and A. Poludnenko, A. Cunningham, and A. Frank (UR, Department of Physics and Astronomy) (p. 227). Testing the assumption of homogeneous mixing in fibrous foams saturated with cryogenic deuterium and tritium, shock passage in wetted-foam mixtures was simulated by the adaptive-mesh, two-dimensional hydrodynamic code AstroBEAR. For foam fibers of diameter ~1/10 µm and relevant foam densities, the mixing length behind the shock is found to be of the order of microns. Transverse motion dampens out sufficiently that, at the mixing region's edge farthest from the shock, Rankine-Hugoniot jump conditions are obeyed to within a few percent and shock speeds are also within a few percent of their homogeneous values. In addition, questions of feedthrough and feedout are addressed, showing that the stability of the shock front, once it leaves the wetted-foam layer, minimizes the effect of feedthrough. As a result, simulations of whole-foam-pellet implosions may model the wetted foam as a homogeneous mixture.

  2. Hans Jürman 85 : Hans Jürman: kes ma olen? / Hans Jürman

    Index Scriptorium Estoniae

    Jürman, Hans, 1923-2014

    2010-01-01

    Hans Jürmani lapsepõlvest, kooliaastatest ning ülikooliajast. Olles hariduselt eesti filoloog on Hans Jürman töötanud ka apteekrina ja õpetajana, kuid suurema osa oma elust raamatukogudes, põhiliselt Tallinna Keskraamatukogus ja Eesti NSV Riiklikus Avalikus Raamatukogus, viimasel ajal tegeleb terminoloogiaga

  3. Ajalool on ajaloolaste nägu / Jean-Claude Schmitt ; interv. Marek Tamm

    Index Scriptorium Estoniae

    Schmitt, Jean-Claude

    2004-01-01

    Intervjuu ajaloolase Jean-Claude Schmittiga. Ilm. ka: Keha, pilt ja unenägu : intervjuu Jean-Claude Scmittiga // Schmitt, Jean-Claude. Püha hurdakoer : Guinefort - lasteravija 13. sajandist. - Tallinn, 2000. - Lk. 296-305 ; Kuidas kirjutatakse ajalugu? // Tamm, Marek. Kuidas kirjutatakse ajalugu? - Tallinn, 2007. - 161-177

  4. Learning Han Cultures on Horseback

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    The "Think Tank in the Plain of Golden Lotuses" played important roles in the founding of the Yuan Dynasty.It came into being because of the enthusiasm of Kublai towards Han cultures and his political ambitions.

  5. Pagari 1 korterelamu restaureerimine = Restoration of an old town apartment building Pagari 1 / Rasmus Tamme, Jaanus Saarepera, Reio Raudsepp

    Index Scriptorium Estoniae

    Tamme, Rasmus

    2015-01-01

    Restaureeritud korterelamu Tallinna vanalinnas Pagari tänav 1, valminud 2014. Arhitektid Rasmus Tamme, Jaanus Saarepera, Reio Raudsepp (ARS Projekt), sisearhitekt Reio Raudsepp. 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

  6. LLE Review Quarterly Report (October-December 2000). Volume 85

    Energy Technology Data Exchange (ETDEWEB)

    Sources, John M. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2000-12-01

    This volume of the LLE Review, covering October-December 2000, begins with an article by R. Betti, M. Umansky, V. Lobatchev, V. N. Goncharov, and R. L. McCrory, who report on the development of a model for the deceleration phase of an imploding inertial fusion capsule (p. 1). The model shows that the ablative flow off the inner shell surface plays a critical role in reducing the growth rate and suppressing short-wavelength modes in the deceleration-phase Rayleigh-Taylor instability. Other articles in this volume are: The Effect of Shock Heating on the Stability of Laser-Driven Targets; Spherical Cavity Expansion in Material with Densification; Design and Performance of a Selectable-Rate Streak-Camera Deflection Ramp Generator; Unique High-Bandwidth, UV Fiber Deliver System for OMEGA Diagnostics Applications; Fabrication and Properties of an Ultrafast NbN Hot-Electron Single-Photon detector; and, Preliminary Design of NIF 2-D SSD.

  7. LLE Review Quarterly Report (April-June 2001). Volume 87

    Energy Technology Data Exchange (ETDEWEB)

    Hinterman, Thomas H. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2001-06-01

    This volume of the LLE Review, covering April–June 2001, features ''A Self-Calibrating, Multichannel Streak Camera for Inertial Confinement Fusion Applications'' by Dr. W. R. Donaldson, R. Boni, R. L. Keck, and P. A. Jaanimagi. This article (p. 109) describes the 60-beam streak camera system used on OMEGA and focuses on the hardware and software calibration techniques that maximize its utility. The system can diagnose each of the beams on every target shot and can measure beam energies with 8% accuracy and timing at 7 ps rms. Beam-to-beam power variations of less than 5% can be detected. Other articles in this volume are: Evolution of Shell Nonuniformities Near Peak Compression of a Spherical Implosion; Multibeam Stimulated Brillouin Scattering from Hot Solid-Target Plasmas; Hot-Electron Effect in Superconductors and Is Applications for Radiation Sensors; and, Scaling Law for Marginal Ignition.

  8. LLE Review: Volume 63. Quarterly report, April--June 1995

    International Nuclear Information System (INIS)

    Craxton, R.S.

    1995-01-01

    This volume of the LLE Review, covering the period of April--June 1995, includes a description of the initial performance results of the upgraded OMEGA laser system. A series of acceptance tests were completed, demonstrating that all 60 beams can irradiate targets with more energy and better beam balance than was required by the Department of Energy's acceptance criteria. Other articles in this volume include a description of a novel energy measurement system used to diagnose all 60 OMEGA beams; a theoretical calculation of the cutoff wave number of the ablative Rayleigh-Taylor instability, applicable to both direct and indirect drive; a description of a new algorithm used for designing distributed phase plates that will produce super-Gaussian focal-plane irradiance profiles: a study of the photoresponse of high-T c YBCO thin films; and a description of magnetorheological finishing, a new process for optics polishing

  9. LLE review. Volume 61, Quarterly report, October--December 1994

    International Nuclear Information System (INIS)

    1994-01-01

    This volume of the LLE review, covering the period of October--December 1994, contains articles on a diagnostic method employing krypton spectroscopy for measurement of temperature and shell-fuel mixing in high-temperature implosions; the first direct assessment of the ion-acoustic decay instability in a large-scale length, hot plasma; measurements of polarization mode dispersion and group-velocity walkaway in birefringent media using a frequency domain interferometer; an evaluation of the magnetic flux dynamics occurring in an optically triggered, thin-film superconducting switch; the effect of slurry fluid chemistry on particle size distribution during aqueous polishing of optical glass; and the influence of thermal and mechanical processing history in the preparation of well-ordered liquid crystal elastomer systems

  10. LLE Review quarterly report, October--December 1992. Volume 53

    Energy Technology Data Exchange (ETDEWEB)

    Meyerhofer, D.D. [ed.

    1992-12-31

    This volume of the LLE Review covers the three-month period October--December 1992. On 18 December, the OMEGA Laser Facility fired its last shot. It will be decommissioned during the next quarter to make room for the OMEGA Upgrade Laser Facility. This volume deals with two areas of interest for the OMEGA Upgrade, the development of advanced x-ray and neutron diagnostics and the development of long-pulse (>1-ns) laser sources. The first three articles discuss the development of time-dependent diagnostics. The development of an x-ray framing camera is described and measurements of the high-voltage pulse propagation in the camera are presented. Time-resolved and time-integrated neutron diagnostics for the OMEGA Upgrade are then discussed. Two schemes for the generation of >1-ns laser pulses are presented. Finally, the activities of the National Laser Users Facility and the GDL and OMEGA laser facilities are summarized.

  11. LLE Review Quarterly Report (April-June 1998). Volume 75

    Energy Technology Data Exchange (ETDEWEB)

    Epstein, Reuben [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    1998-06-01

    This volume of the LLE Review, covering the period April–June 1998, includes a report on a recent series of experiments, performed by A. Babushkin, M. Guardalben, R. Keck, and W. Seka, that demonstrate a new scheme for converting the infrared light of OMEGA to the third harmonic in the ultraviolet over a bandwidth that is significantly wider than has been previously attainable. This innovative scheme, employing a second tripling crystal in addition to the doubler-tripler pair currently in use, was proposed by D. Eimerl at Lawrence Livermore National Laboratory and adapted to the OMEGA system by S. Craxton and S. Oskoui, a recent participant in LLE’s Summer High-School Research Program. Wider bandwidths on OMEGA will allow the use of broadband beam smoothing with faster smoothing times than have been employed until now.

  12. LLE Review Quarterly Report (July-September 1998). Volume 76

    Energy Technology Data Exchange (ETDEWEB)

    Epstein, Reuben [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    1998-09-01

    This volume of the LLE Review, covering the period July-September 1998, includes reports on two of the newest subsystems in the OMEGA laser facility. A. V. Okishev, M. D. Skeldon, and W. Seka have developed a highly stable, diode-pumped Nd:YLF master oscillator for the OMEGA laser system. This new master oscillator produces either single-frequency Q-switched pulses or cw radiation for the OMEGA pulse-shaping system. The switch-over between these two regimes requires no laser realignment. The new master oscillator is completely computer controlled and has been operating continuously in OMEGA for six months without operator intervention. A. Babushkin, W. Bittle, S. A. Letzring, M. D. Skeldon, and W. Seka have designed a negative-feedback–controlled regenerative amplifier that has been part of the OMEGA laser system for the past two years. The negative feedback makes the energy output of the regenerative amplifier stable and insensitive to the variations in pulse energy. This amplifier’s long-term output energy stability is the highest ever demonstrated for a millijoule-level laser system, either flashlamp pumped or diode pumped. Other articles in this volume are titled: Transcient Bandwidth Analysis of Photoconductive Microwave Switches Implemented in the OMEGA Pulse-Shaping System; Simulations of Near-Field Intensity Modulations in High-Intensity Laser Beams due to Self- and Cross-Phase Modulation Between Orthogonally Polarized Laser Beams Emerging from a Diamond-Turned KDP Wedge; X-Ray Radiographic System Used to Measure the Evolution of Broadband Imprint in Laser-Driven Planar Targets; Collisionless Damping of Localized Plasma Waves in Laser-Produces Plasmas and Application to Stimulated Raman Scattering in Filaments; LLE's Summer High School Research Program; FY98 Laser Facility Report; and, National Laser Users' Facilty News.

  13. LLE review. Quarterly report, July 1997--September 1997

    International Nuclear Information System (INIS)

    1998-01-01

    This volume of the LLE Review, covering the period July--September 1997, begins with a general introduction to LLE's experimental physics program and a report on recent results. This article includes a useful summary of the system's operational capabilities and system parameters. Other highlights of the wide variety of research presented in this issue are: a promising method to directly observe the cold compressed shell of an imploding target. The shell is normally observed by backlighting. The proposal described here is to use a high-Z dopant that fluoresces under radiation from the hot core in the Kα line. A study of the instabilities associated with near-forward stimulated Brillouin scattering. It includes a calculation of the saturation times and steady-state gain exponents. A successful program of pulse shaping for the OMEGA laser system. Examples of a variety of pulse shapes that can be programmed are presented. A description of the angular-scattering characteristics of ferroelectric liquid crystal electro-optical devices operating in transient and extended scattering modes. The possibility of applying these devices as modulators in practical IR imaging systems is evaluated. A faster method of shaping and finishing IR materials by the use of magnetorheological fluids. Detailed specifications and test results are included. An integrated circuit tester based on interferometric imaging. This technique holds promise of ultrafast noninvasive testing of the voltage states of sections of microchips. Continued success of the Laboratory's High School Summer Research Program. The program, which started in 1989, has brought several dozen young people into intimate contact with modern science and technology. The volume concludes with a Laser Facility Report and the National Laser Users' Facility News

  14. LLE review. Quarterly report, July 1997--September 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    This volume of the LLE Review, covering the period July--September 1997, begins with a general introduction to LLE`s experimental physics program and a report on recent results. This article includes a useful summary of the system`s operational capabilities and system parameters. Other highlights of the wide variety of research presented in this issue are: a promising method to directly observe the cold compressed shell of an imploding target. The shell is normally observed by backlighting. The proposal described here is to use a high-Z dopant that fluoresces under radiation from the hot core in the K{alpha} line. A study of the instabilities associated with near-forward stimulated Brillouin scattering. It includes a calculation of the saturation times and steady-state gain exponents. A successful program of pulse shaping for the OMEGA laser system. Examples of a variety of pulse shapes that can be programmed are presented. A description of the angular-scattering characteristics of ferroelectric liquid crystal electro-optical devices operating in transient and extended scattering modes. The possibility of applying these devices as modulators in practical IR imaging systems is evaluated. A faster method of shaping and finishing IR materials by the use of magnetorheological fluids. Detailed specifications and test results are included. An integrated circuit tester based on interferometric imaging. This technique holds promise of ultrafast noninvasive testing of the voltage states of sections of microchips. Continued success of the Laboratory`s High School Summer Research Program. The program, which started in 1989, has brought several dozen young people into intimate contact with modern science and technology. The volume concludes with a Laser Facility Report and the National Laser Users` Facility News.

  15. LLE Review. Volume 68, July--September 1996

    International Nuclear Information System (INIS)

    1996-07-01

    This volume of the LLE Review, covering the period of July-September 1996, includes a description of an important experiment carried out on OMEGA by researchers from LANL, LLNL, and LLE to demonstrate the feasibility of using OMEGA for indirect drive. Additional topics include tetrahedral hohlraums, the speckle properties of phase- converted laser beams, design criteria for SSD phase modulators, and the design of slab amplifiers. Highlights of the research presented in this issue are (1) Results from the proof-of-principle indirect- drive experiments in which up to 40 OMEGA beams were used to irradiate cylindrical hohlraums. Nova results were reproduced, and new capabilities not available on other lasers were demonstrated. (2) A discussion of tetrahedral hohlraums (spherical hohlraums with four laser entrance holes) as a means of achieving better capsule irradiation uniformity. Tetrahedral hohlraums also allow the use of all 60 OMEGA beams and may provide an alternate route to ignition on the NIF. (3) An analysis of the residual target irradiation nonuniformity due to the fine laser speckle remaining on the beam after being phase converted by the DPP's. A model shows how a uniformly ablating plasma atmosphere reduces the speckle contribution to the effective time-averaged irradiation nonuniformity. (4) A discussion of the theory, design, manufacture, testing, and implementation of the microwave SSD phase modulators used on OMEGA for two-dimensional SSD. The modulators are capable of operating in the gigahertz frequency range. (5) A discussion of the design and performance of a large-aperture, high-gain Nd:glass zig-zag slab amplifier for materials testing. The design incorporates improvements from previous work in addition to improvements obtained from careful design choices guided by analytic calculations

  16. Highly sensitive reversed-phase high-performance liquid chromatography assay for the detection of Tamm-Horsfall protein in human urine.

    Science.gov (United States)

    Akimoto, Masaru; Hokazono, Eisaku; Ota, Eri; Tateishi, Takiko; Kayamori, Yuzo

    2016-01-01

    Tamm-Horsfall protein (also known as uromodulin) is the most abundant urinary protein in healthy individuals. Since initially characterized by Tamm and Horsfall, the amount of urinary excretion and structural mutations of Tamm-Horsfall protein is associated with kidney diseases. However, currently available assays for Tamm-Horsfall protein, which are mainly enzyme-linked immunosorbent assay-based, suffer from poor reproducibility and might give false negative results. We developed a novel, quantitative assay for Tamm-Horsfall protein using reversed-phase high-performance liquid chromatography. A precipitation pretreatment avoided urine matrix interference and excessive sample dilution. High-performance liquid chromatography optimization based on polarity allowed excellent separation of Tamm-Horsfall protein from other major urine components. Our method exhibited high precision (based on the relative standard deviations of intraday [≤2.77%] and interday [≤5.35%] repetitions). The Tamm-Horsfall protein recovery rate was 100.0-104.2%. The mean Tamm-Horsfall protein concentration in 25 healthy individuals was 31.6 ± 18.8 mg/g creatinine. There was a strong correlation between data obtained by high-performance liquid chromatography and enzyme-linked immunosorbent assay (r = 0.906), but enzyme-linked immunosorbent assay values tended to be lower than high-performance liquid chromatography values at low Tamm-Horsfall protein concentrations. The high sensitivity and reproducibility of our Tamm-Horsfall protein assay will reduce the number of false negative results of the sample compared with enzyme-linked immunosorbent assay. Moreover, our method is superior to other high-performance liquid chromatography methods, and a simple protocol will facilitate further research on the physiological role of Tamm-Horsfall protein. © The Author(s) 2015.

  17. Tamm-plasmon polaritons in one-dimensional photonic quasi-crystals.

    Science.gov (United States)

    Shukla, Mukesh Kumar; Das, Ritwick

    2018-02-01

    We present an investigation to ascertain the existence of Tamm-plasmon-polariton-like modes in one-dimensional (1D) quasi-periodic photonic systems. Photonic bandgap formation in quasi-crystals is essentially a consequence of long-range periodicity exhibited by multilayers and, thus, it can be explained using the dispersion relation in the Brillouin zone. Defining a "Zak"-like topological phase in 1D quasi-crystals, we propose a recipe to ascertain the existence of Tamm-like photonic surface modes in a metal-terminated quasi-crystal lattice. Additionally, we also explore the conditions of efficient excitation of such surface modes along with their dispersion characteristics.

  18. LLE review. Quarterly report, October--December 1991: Volume 49

    Energy Technology Data Exchange (ETDEWEB)

    Keck, R.L. [ed.

    1991-12-31

    This volume of the LLE Review, covering the period October-December 1991, contains articles on the analysis of argon-filled target experiments, and a theoretical analysis of the impact of nonlocal heat transport in laser filamentation in plasmas. In the Advanced Technology section there is an article on mechanisms that affect thin-film conductivity, and a report on the gain characteristics of the 20-cm SSA prototype amplifier to be used in the OMEGA Upgrade. Finally, the activities of the National Laser Users Facility and the GDL and OMEGA laser facilities are summarized. Highlights of the research reported in this issue are: argon radiation from argon-filled, polymer-shell targets is used as a core-temperature diagnostic and density diagnostic of the surrounding region in a regime where the argon line radiation is strongly absorbed. A theoretical analysis of the impact of nonlocal heat transport on laser filamentation in plasmas is developed. The resulting model is compared with experimental observations and the implications for ICF are discussed. A study of thermal conductivity in thin films seeks to identify mechanisms that result in degradation of thin-film conductivity. Identifying these mechanisms can lead to changes in the thin-film manufacture that will improve their resistance to laser damage.

  19. LLE 1995 annual report, October 1994--September 1995

    International Nuclear Information System (INIS)

    1996-01-01

    The fiscal year ending September 1995 (FY95) concluded the third year of the cooperative agreement (DE-FC03-92SF19460) with the U.S. Department of Energy (DOE). This report summarizes research at the Laboratory for Laser Energetics (LLE) and reports on the successful completion of the OMEGA Upgrade. Previous annual reports describe the OMEGA Upgrade design. The preliminary design for the system was complete in October 1989 and the detailed design started in October 1990. The original 24-beam OMEGA system was decommissioned in December 1992 as construction for the OMEGA Upgrade began. We discuss the initial performance results (p. 99) of the upgraded OMEGA laser system. All acceptance tests were completed, and we demonstrated that all 60 beams can irradiate a target with more energy and better beam balance than was required by DOE's acceptance criteria. We are most proud that all program milestones were met or exceeded, and that the system was completed on time and on budget

  20. LLE 1995 annual report, October 1994--September 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    The fiscal year ending September 1995 (FY95) concluded the third year of the cooperative agreement (DE-FC03-92SF19460) with the U.S. Department of Energy (DOE). This report summarizes research at the Laboratory for Laser Energetics (LLE) and reports on the successful completion of the OMEGA Upgrade. Previous annual reports describe the OMEGA Upgrade design. The preliminary design for the system was complete in October 1989 and the detailed design started in October 1990. The original 24-beam OMEGA system was decommissioned in December 1992 as construction for the OMEGA Upgrade began. We discuss the initial performance results (p. 99) of the upgraded OMEGA laser system. All acceptance tests were completed, and we demonstrated that all 60 beams can irradiate a target with more energy and better beam balance than was required by DOE`s acceptance criteria. We are most proud that all program milestones were met or exceeded, and that the system was completed on time and on budget.

  1. LLE Review Quarterly Report (October-December 2001). Volume 89

    Energy Technology Data Exchange (ETDEWEB)

    Donaldson, William R. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2001-12-01

    This volume of the LLE Review, covering October-December 2001, features “Time-Integrated Light Images of OMEGA Implosions” by P. Morley and W. Seka (p. 1). E. Kowaluk initiated this project for aesthetic rather than scientific reasons when he began taking visible light photographs of imploding OMEGA targets. These beautiful images are used to communicate LLE’s mission to the general public. A closer examination of the images revealed a one-to-one correspondence between the bright spots in the image and each of the 60 laser beams. The intensity of the bright spots has been related to refraction and absorption in the plasma surrounding the imploding target. These photographs are now proving to be the basis of a new laser-plasma interaction diagnostic. Other articles in this volume are titled the following: Analytical Model of Nonlinear, Single-Mode, Classical Rayleigh-Taylor Instability at Arbitrary Atwood Numbers; A High-Pass Phase Plate Design for OMEGA and the NIF; Advanced Tritium Recovery System; Establishing Links Between Single Gold Nanoparticles Buried Inside SiO2 Thin Film and 351-nm Pulsed-Laser-Damage Morphology; Resistive Switching Dynamics in Current-Biased Y-Ba-Cu-O Microbridges Excited by Nanosecond Electrical Pulses; and, Properties of Amorphous Carbon Films.

  2. LLE Review Quarterly Report (October - December 2007). Volume 113

    Energy Technology Data Exchange (ETDEWEB)

    Zuegel, Jonathan D. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2007-12-01

    This volume of the LLE Review, covering October–December 2007, features “High-Intensity Laser–Plasma Interactions in the Refluxing Limit,” by P. M. Nilson, W. Theobald, J. Myatt, C. Stoeckl, M. Storm, O. V. Gotchev, J. D. Zuegel, R. Betti, D. D. Meyerhofer, and T. C. Sangster. In this article (p. 1), the authors report on target experiments using the Multi-Terawatt (MTW) Laser Facility to study isochoric heating of solid-density targets by fast electrons produced from intense, short-pulse laser irradiation. Electron refluxing occurs due to target-sheath field effects and contains most of the fast electrons within the target volume. This efficiently heats the solid-density plasma through collisions. X-ray spectroscopic measurements of absolute Kα (x-radiation) photon yields and variations of the Kβ/Kα b emission ratio both indicate that laser energy couples to fast electrons with a conversion efficiency of approximately 20%. Bulk electron temperatures of at least 200 eV are inferred for the smallest mass targets.

  3. LLE Review Quarterly Report (January-March 2000). Volume 82

    Energy Technology Data Exchange (ETDEWEB)

    Radha, P. B. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2000-03-01

    This volume of the LLE Review, covering the period January-March 2000, includes a report on OMEGA cryogenic target designs for the soon-to-be-commissioned OMEGA Cryogenic Target Handling System. R. P. J. Town, J. A. Delettrez, R. Epstein, V. N. Goncharov, P. W. McKenty, P. B. Radha, and S. Skupsky use two-dimensional hydrodynamic simulations in conjunction with a stability analysis model to study the performance of OMEGA cryogenic capsules. They show that these targets are energy-scaled from the NIF ignition designs and have similar 1-D behavior and stability properties. This similarity will facilitate the extrapolation of cryogenic target studies on OMEGA to ignition targets on the NIF. Other articles in this volume are: Imprint Reduction using an Intensity Spike in Omega Cryogenic Targets; Measurement of Preheat Due to Fast Electrons in Laser Implosions; Holographic Transmission Gratings for Spectral Dispersion; Laser Beam Smoothing Caused by the Small-Spatial-Scale B-Integral; Three-Dimensional Modeling of Capsule Implosions in OMEGA Tetrahedral Hohlraums; and, Nanoindentation Hardness of Particles Used in Magnetoheological finishing (MRF).

  4. LLE Review Quarterly Report (January-March 2002). Volume 90

    Energy Technology Data Exchange (ETDEWEB)

    Donaldson, William R. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2002-03-01

    This volume of the LLE Review, covering January-March 2002, features “First Results from Cryogenic Target Implosions on OMEGA” by C. Stoeckl et al. (p. 49). This article describes initial results from direct-drive spherical cryogenic target implosions on the 60-beam OMEGA laser system. These experiments are part of the scientific base leading to direct-drive ignition implosions planned for the National Ignition Facility (NIF). Results shown include neutron yield, secondary-neutron and proton yields, the time of peak neutron emission, and both time-integrated and time-resolved x-ray images of the imploding core. The experimental values are compared with 1-D numerical simulations. The target with an ice-layer nonuniformity of srms = 9 mm showed 30% of the 1-D predicted neutron yield. These initial results are encouraging for future cryogenic implosions on OMEGA and the NIF. Other articles in this issue are titled the following: Equation-of-State Measurements of Porous Materials on OMEGA: Numerical Modeling; Observations of Modulated Shock Waves in Solid Targets Driven by Spatially Modulated Laser Beams; Time-Dependent Electron Thermal Flux Inhibition in direct-Drive Laser Implosions; Precision Spectral Sculpting of Broadband FM Pulses Amplified in a Narrowband Medium; Electric-Field-Induced Motion of Polymer Cholesteric Liquid Crystal Flakes in a Moderately Conductive Fluid; and, Femtosecond Response of a Freestanding LT-GaAs Photoconductive Switch.

  5. Han greb øjeblikket

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2017-01-01

    Helmut Kohl havde en sans for historiens store bevægelser og for at slå til, når muligheden bød sig. Han var også ansvarlig for mange af de skævheder, der har plaget det forenede Tyskland og det uforenede Europa lige siden kommunismens sammenbrud.......Helmut Kohl havde en sans for historiens store bevægelser og for at slå til, når muligheden bød sig. Han var også ansvarlig for mange af de skævheder, der har plaget det forenede Tyskland og det uforenede Europa lige siden kommunismens sammenbrud....

  6. LLE Review Quarterly Report July-September 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-12-01

    This volume of the LLE Review, covering July-September 2000, begins with an article by T. R. Boehly, V. N. Goncharov, O. Gotchev, J. P. Knauer, D. D. Meyerhofer, D. Oron, S. P. Regan, Y. Srebro, W. Seka, D. Shvarts, S. Skupsky, and V.A. Smalyuk, who describe measurements of the effect of beam smoothing and pulse shape on imprinting. (Imprinting is defined as the imposition of pressure perturbations on the target by spatial variations in the laser intensity.) A principal result is the observation of reduced levels of imprint with the higher beam smoothing afforded by 1-THz smoothing by spectral dispersion (SSD). Additional highlights of research presented in this issue are: (1) P. W. McKenty, V. N. Goncharov, R. P. J. Town, S. Skupsky, R. Betti, and R. L. McCrory describe calculations of directly driven ignition capsule performance on the National Ignition Facility (NIF). The authors detail how the various contributors to implosion disruption (laser imprint, power imbalance, and target roughness) affect target performance and final gain. The conclusions are obtained by examining the simulated target evolution with the two-dimensional hydrodynamics computer code ORCHID. (2) D. D. Meyerhofer, J. A. Delettrez, R. Epstein, V. Yu. Glebov, V. N. Goncharov, R. L. Keck, R. L. McCrory, P. W. McKenty, F. J. Marshall, P. B. Radha, S. P. Regan, S. Roberts, W. Seka, S. Skupsky, V. A. Smalyuk, C. Sorce, C. Stoeckl, J. M. Soures, R. P. J. Town, B. Yaakobi, J. D. Zuegel, J. Frenje, C. K. L1,R. D. Petrasso, F. Seguin, K. Fletcher, S. Padalino, C. Freeman, N. Izumi, R. Lerche, T. W. Phillips, and T. C. Sangster describe the results of a series of direct-drive implosions of gas-fusion-fuel-filled plastic shells performed on the OMEGA laser system. The experiments include those performed with 1-THZ SSD and high-quality power balance. (3) V. Yu. Glebov, D. D. Meyerhofer, C. Stoeckl, and J. D. Zuegel describe the technique of measuring secondary neutron yield (DT neutron yield from D

  7. [Neurousurpation--the expropriation and suppression of Dölle's neurobiological pioneer work].

    Science.gov (United States)

    Bertram, Wulf

    2011-08-01

    The discovery of a hitherto unpublished dissertational thesis in the archive of a publishing house has lead to a lost publication by Ernst August Dölle. In this manuscript, the author reports on the stimulation of a cerebral libido area in the dog, long before Olds and Milner published their work on the discovery of the rewarding area. The reasons for the suppression of this early publication by Dölle are investigated and are ascribed to an effort to use his neurobiologic research for secret mental manipulation experiments of the CIA at the beginning of the Cold War. George Thieme Verlag KG Stuttgart · New York.

  8. LLE Review Quarterly Report January - March 2012. Volume 130

    Energy Technology Data Exchange (ETDEWEB)

    Shvydky, Alex [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2012-03-01

    This volume of the LLE Review, covering January–March 2012, features “OMEGA Polar-Drive Target Designs,” by P. B. Radha, J. A. Marozas, F. J. Marshall, A. Shvydky, T. J. B. Collins, V. N. Goncharov, R. L. McCrory, P. W. McKenty, D. D. Meyerhofer, T. C. Sangster, and S. Skupsky. This article (p. 57) describes low-adiabat, cryogenic-deuterium–tritium, and warm-plastic-shell polar-drive (PD)–implosion designs for the OMEGA laser. The designs are at two different on-target laser intensities, each at a different in-flight aspect ratio (IFAR). The first design permits one to study implosion energetics and target performance closer to ignition-relevant intensities (7 X 1014 W/cm2 at the quarter-critical surface), where nonlocal heat conduction and laser–plasma interactions can play an important role, but at lower values of IFAR (~22). The second design permits one to study implosion energetics and target performance at a lower intensity (3 X 1014 W/cm2) but at higher IFAR (~32), where the shell instability can play an important role. The higher IFAR designs are accessible on the existing OMEGA Laser System only at lower intensities. Implosions at ignition-relevant intensities can be obtained only by reducing target radius, although only at smaller values of IFAR. Polar-drive geometry requires repointing the laser beams to improve shell symmetry. The higher-intensity designs optimize target performance by repointing beams to a lesser extent and compensate for the reduced equatorial drive by increasing beam energies for the repointed beams and using custom beam profiles that improve equatorial illumination at the expense of irradiation at higher latitudes. These designs will be studied when new phase plates for the OMEGA Laser System, corresponding to the smaller target radii and custom beam profiles, are obtained. Implosion results from the combined set of high-intensity and high-IFAR implosions should yield valuable

  9. "Küsse lat's ..." : [luuletused] / Kauksi Ülle

    Index Scriptorium Estoniae

    Kauksi Ülle, pseud., 1962-

    2002-01-01

    Sisu: "Küsse lat's ..." ; "Vanaimä, ma lupa, ku suurõss kasu ..." ; "Mis-ti küsüt, et ..." ; Ussõ pääl üteld ; "Mis' sõs ku olõ 'pihlõ' ma kesk umma mäke ..." "Kos' sa olt? ..." ; "Maarahva miil ..." ; "Havvakirju ragi yts miis ..." ; Hanõ vai luigõ ; Võlg ; Mu viimäne laul sullõ ; "üts korgõ puu pak mullõ paika ...". Eluloolisi andmeid autori kohta lk. 369

  10. Hans Blix appointed Director General

    International Nuclear Information System (INIS)

    1981-01-01

    On 1 December 1981, Dr Hans Blix took office as Director General of the International Atomic Energy Agency in succession to Dr Sigvard Eklund who has headed the IAEA since 1961. The Agency's Board of Governors nominated Dr Blix by acclamation on 26 September. His appointment was unanimously approved by the final session of the 25th regular session of the General Conference of the IAEA the same day. The President of the Conference, Ambassador Manaspas Xuto, administered the oath of office to Dr Blix at the final plenary meeting that day. Hans Blix was born in 1928 in Uppsala He studied at the University of Uppsala, at Columbia University, where he was also a research graduate and at Cambridge, where he received his Ph D In 1959 he became Doctor of Laws at the Stockholm University and in 1960 was appointed associate professor in international law. From 1963 to 1976 Dr Blix was Head of Department at the Ministry for Foreign Affairs and served as Legal Adviser on International Law. In 1976 he became Undersecretary of State at the Ministry for Foreign Affairs in charge of international development co-operation He was appointed Minister for Foreign Affairs in October 1978 In September 1979 he was again appointed Undersecretary of State at the Ministry for Foreign Affairs in charge of international development co-operation. Since 1961 he has been a member of Sweden's delegation to the United Nations General Assembly, and from 1962 to 1978 a member of the Swedish delegation to the Conference on Disarmament in Geneva. He has written several books on subjects associated with international and constitutional law and was leader of the Liberal Campaign Committee in favour of retention of the Swedish nuclear energy program in the referendum in 1980

  11. 32. keskkoolis saab jälle teatriharidust / Liisa-Indra Kärt

    Index Scriptorium Estoniae

    Kärt, Liisa-Indra

    2003-01-01

    Alates sügisest saab 32. keskkoolis jälle õppida teatrieriala, 29.03 toimunud vastuvõtukatsetel osales 50 teatrihuvilist noort. Konkurss treatriklassi oli ootamatult tihe, teatriklass tegutses 32. koolis alates selle loomisest aastal 1971-1980

  12. Ülemiste City maastikukujundus / Ülle Grišakov

    Index Scriptorium Estoniae

    Grišakov, Ülle, 1953-

    2009-01-01

    Esimene Tallinna erapark, ainulaadne projekt, mis kombineerib vana industriaalarhitektuuri uute hoonetega ning linnamaastiku värskete lahendustega. Säilitatud on kõrghaljastus. Projekti autorid on Olga Borisik, Triin Järve ja Ülle Grišakov OÜ Kivisilla, 2005

  13. Väitlus : vastuseks eelolevale / Enn Küng, Kari Tarkiainen, Ülle Tarkiainen

    Index Scriptorium Estoniae

    Küng, Enn, 1963-

    2015-01-01

    Väitlus Enn Küngi ning Kari ja Ülle Tarkiaineni vahel, mille aluseks on 2015. a. Akadeemia 8. numbris ilmunud Enn Küngi arvustis Tarkiainenite raamatule "Provinsen bortom havet. Estlands svenska historia 1561-1710" (Lk. 1491-1499)

  14. Kuidas saada hakkama õpilaskoduta? / Ülle Luisk, Toomas Mitt, Aivar Part ... [jt.

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastasid: Viljandi gümnaasiumi direktor Ülle Luisk, Tõstamaa keskkooli direktor Toomas Mitt, Rakvere gümnaasiumi direktor Aivar Part, Tartu kutsehariduskeskuse direktor Andrus Kompus, Võru Kreutzwaldi gümnaasiumi direktor Katrin Martinfeld

  15. Säravad ja kirglikud, naised mis naised / Liis Haab, Inga Allik ja Elisabet Tamm ; intervjueerinud Karli Randoja

    Index Scriptorium Estoniae

    Haab, Liis, 1987-

    2010-01-01

    Eestimaises seriaalis "Pilvede all" mängivad õdesid näitlejannad Liis Haab, Inga Allik ja Elisabet Tamm. Artiklis räägivad nad oma rollidest, koostööst võtteplatsil, endast ja oma riietumisstiilist

  16. Mille poolest on algav õppeaasta teile eriline? / Valmar Pantšenko, Martin Adamson, Maire Tamm, Eve Reisalu

    Index Scriptorium Estoniae

    2012-01-01

    Küsimusele vastavad: Tartu Täiskasvanute Gümnaasiumi abiturient Valmar Pantšenko, Eesti meister motokrossis klassis Quad 100 Martin Adamson, Tamsalu Gümnaasiumi õppealajuhataja Maire Tamm ja Ristiku põhikooli õpetaja-metoodik Eve Reisalu

  17. Ülle Kaljuste : Ma kartsin töötuks jääda / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    2005-01-01

    25., 26. ja 27. veebruaril etendub Draamateatris J. Haydni lustlik õukonnaooper "Elu kuu peal" ("Il Mondo Della Luna"), mille seadsid lavale Andrus Vaarik, tema assistent Ülle Kaljuste ning dirigent Tõnu Kaljuste

  18. Hans Küng: "Projekt Weltethos "

    OpenAIRE

    Altmanninger, Maria

    2002-01-01

    Bei dieser Arbeit werde ich mich vor Allem auf zwei Werke beziehen: Küng,Hans:Projekt Weltethos.Piper.München 1990. Küng,Hans;Kuschel,Karl-Josef (Hg.):Weltfrieden durch Religionsfrieden.Die unter Punkt Acht aufgeführte Stellungnahme wurde ausschließlich von mir verfasst.

  19. Kuljetuskustannusten vertailu vientitoimituksissa Ruotsista Venäjälle : case: Yritys X, lohituotteet

    OpenAIRE

    Manner, Tatjana

    2013-01-01

    Tämä opinnäytetyö käsittelee kuljetuskustannusten vertailua vientitoimituksissa Ruotsista Venäjälle. Työn tarkoituksena on löytää case-yritykselle edulliset huolitsijat autokuljetuksin ja ovelta ovelle -lentokuljetuksin vietäviin lohituotteiden toimituksiin. Tutkimuksen osatavoitteena on kuvailla vientiin tarvittavia kuljetusasiakirjoja ja selvittää asiakirjojen laadinnasta aiheutuvia kustannuksia. Työn teoreettisessa osuudessa käsitellään logistiikkapalvelujen hankintaa, huolintaliikkeit...

  20. Determination of DDT and metabolites in surface water and sediment using LLE, SPE, ACE and SE.

    Science.gov (United States)

    Sibali, Linda L; Okonkwo, Jonathan O; Zvinowanda, Caliphs

    2009-12-01

    Surface water and sediment samples collected from Jukskei River in South Africa, were subjected to different extraction techniques, liquid-liquid (LLE), solid-phase extraction (SPE), activated carbon extraction (ACE) and soxhlet extraction (SE) for sediment. The samples were extracted with dichloromethane, cleaned in a silica gel column and the extracts quantified using a Varian 3800 GC-ECD. The percentage recovery test for 2,4'DDT, DDE and DDD and 4,4'DDT, DDE and DDD in water ranged from 80%-96% and 76%-95% (LLE); 56%-76% and 56%-70% (SPE) and 75%-84% (ACE), respectively; while that recoveries for sediment samples varied from 65%-95% for 2,4'DDT, DDE and DDD and 80%-91% for 4,4'DDT, DDE and DDD. The high recoveries exhibited by ACE compared very well with LLE and SE. This was not the case with SPE which exhibited the lowest value of recoveries for both 2,4 and 4,4'DDD, DDE and DDT standard samples. The mean concentrations of DDT and metabolites ranged from nd-1.10 μg/L, nd-0.80 μg/L, nd-1.21 μg/L and 1.92 μg/L for LLE, SPE, ACE and SE, respectively. The total DDT (2,4' and 4,4'-DDT) in water and sediment samples ranged from 1.20-3.25 μg/L and 1.82-5.24 μg/L, respectively. The low concentrations of the DDT metabolites obtained in the present study may suggest a recent contamination of the river by DDT.

  1. OpenOffice.org -toimisto-ohjelmiston soveltuvuus Sastamalan Tukipalvelu Oy:lle : selvitys

    OpenAIRE

    Ojanen, Olli-Veikko

    2009-01-01

    Tässä opinnäytetyössä selvitettiin OpenOffice.org toimisto-ohjelmiston soveltuvuutta Sastamalan Tukipalvelu Oy:lle, joka huolehtii osakkaittensa tieto-, talous- ja henkilöstöhallinnon palveluista. Sastamalan Tukipalvelu Oy:n osakkaina ovat Kiikoisten, Lavian ja Punkalaitumen kunnat, Sastamalan kaupunki, Sastamalan perusturvakuntayhtymä sekä Sastamalan koulutuskuntayhtymä. Selvityksen tavoitteena oli tuoda esille OpenOffice.org -toimisto-ohjelmistoon siirtymisen hyötyjä, joi...

  2. Improved radioimmunoassay for urinary Tamm-Horsfall glycoprotein. Investigation and resolution of factors affecting its quantification

    Energy Technology Data Exchange (ETDEWEB)

    Dawney, A B.St.J.; Thornley, C; Cattell, W R [Saint Bartholomew' s Hospital, London (UK)

    1982-09-15

    A rapid specific radioimmunoassay has been used to measure Tamm-Horsfall glycoprotein (TH glycoprotein) in urine, and the method described. The apparent concentration increased with increasing dilution of urine in water, reaching a plateau at 1 in 20. This increase was greater the higher the osmolality and TH glycoprotein concentration and the lower the pH of the original sample. The apparent concentration of TH glycoprotein in neat or diluted urine was not affected by freezing or by storage at 4/sup 0/C or room temperature for at least 2 days. A physiological range for the urinary excretion rate was established as 22-56 mg/24h, (considerably higher than the amount present in serum) based on samples from 29 individuals with normal renal function, as defined by their creatinine clearance. There was no significant correlation between serum concentrations of TH glycoprotein and its urinary excretion rate, nor between urinary excretion rate and creatinine clearance.

  3. Tamm-Horsfall protein in urine after uninephrectomy/transplantation in kidney donors and their recipients

    DEFF Research Database (Denmark)

    Torffvit, O; Kamper, A L; Strandgaard, S

    1997-01-01

    Tamm-Horsfall protein (THP) is a large glycoprotein with unknown physiological function synthesized in the thick ascending limb of the loop of Henle. Urinary THP has recently been suggested as being suitable for monitoring the functional state of transplanted kidneys. In the present study......, the urinary excretion of THP after uninephrectomy and transplantation among relatives was determined in order to study the influence of the acute reduction in renal mass on the excretion of this peptide. Glomerular filtration rate (GFR), estimated by the plasma clearance of 51Cr-EDTA, and the excretion rate...... of THP were measured 2 days before nephrectomy and 5, 12, 26 and 54 days after nephrectomy/transplantation in 22 healthy living kidney donors and in 16 of their recipients. In the donors, THP excretion rate of the kidney to remain in the donor was 22.3 micrograms/min before and 33.7 micrograms/min at 5...

  4. Coupled Optical Tamm States in a Planar Dielectric Mirror Structure Containing a Thin Metal Film

    International Nuclear Information System (INIS)

    Zhou Hai-Chun; Yang Guang; Lu Pei-Xiang; Wang Kai; Long Hua

    2012-01-01

    The coupling between two optical Tamm states (OTSs) with the same eigenenergy is numerically investigated in a planar dielectric mirror structure containing a thin metal film. The reflectivity map in this structure at normal incidence is obtained by applying the transfer matrix method. Two splitting branches appear in the photonic bandgap region when both adjacent dielectric layers of metal film are properly set. The splitting energy of two branches strongly depends on the thickness of the metal film. According to the electric field distribution in this structure, it is found that the high-energy branch corresponds to the antisymmetric coupling between two OTSs, while the low-energy branch is associated with the symmetric coupling between two OTSs. Moreover, the optical difference frequency of two branches is located in a broad terahertz region. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  5. All-optical bistable logic control based on coupled Tamm plasmons.

    Science.gov (United States)

    Zhang, Wei Li; Jiang, Yao; Zhu, Ye Yu; Wang, Fen; Rao, Yun Jiang

    2013-10-15

    A method for realizing low-threshold all-optical bistable logic control is proposed based on Tamm plasmons (TPs), which are formed in an asymmetric dielectric Bragg reflector (DBR)-metal-DBR (ADMD) structure with a layer of Kerr medium embedded. The ADMD structure supports two TPs due to coupling of trapped modes at each metal-DBR interface, generating two dips in the structure's reflection spectrum. Thus, control (i.e., pump) and controlled (i.e., probe) light with wavelengths close to the two dips, respectively, can be imported. It is verified theoretically that, thanks to the enhanced Kerr nonlinearity related to excitation of high-quality TP, bistable switching at very low injection intensity can be initiated by strength or direction variation of the pump. Meanwhile, the probe changes correspondingly with the pump. Thus, all-optical bistable logic operation of the probe can be controlled by the pump.

  6. Sensitive singular-phase optical detection without phase measurements with Tamm plasmons

    Science.gov (United States)

    Boriskina, Svetlana V.; Tsurimaki, Yoichiro

    2018-06-01

    Spectrally-tailored interactions of light with material interfaces offer many exciting applications in sensing, photo-detection, and optical energy conversion. In particular, complete suppression of light reflectance at select frequencies accompanied by sharp phase variations in the reflected signal forms the basis for the development of ultra-sensitive singular-phase optical detection schemes such as Brewster and surface plasmon interferometry. However, both the Brewster effect and surface-plasmon-mediated absorption on planar interfaces are limited to one polarization of the incident light and oblique excitation angles, and may have limited bandwidth dictated by the material dielectric index and plasma frequency. To alleviate these limitations, we design narrow-band super-absorbers composed of plasmonic materials embedded into dielectric photonic nanostructures with topologically-protected interfacial Tamm plasmon states. These structures have planar geometry and do not require nanopatterning to achieve perfect absorption of both polarizations of the incident light in a wide range of incident angles, including the normal incidence. Their absorption lines are tunable across a very broad spectral range via engineering of the photon bandstructure of the dielectric photonic nanostructures to achieve reversal of the geometrical phase across the interface with the plasmonic absorber. We outline the design strategy to achieve perfect absorptance in Tamm structures with dissipative losses via conjugate impedance matching. We further demonstrate via modeling how these structures can be engineered to support sharp asymmetric amplitude resonances, which can be used to improve the sensitivity of optical sensors in the amplitude-only detection scheme that does not require use of bulky and expensive ellipsometry equipment.

  7. Bound-state problem in the light-front Tamm-Dancoff approximation: Numerical study in 1+1 dimensions

    International Nuclear Information System (INIS)

    Harindranath, A.; Perry, R.J.; Shigemitsu, J.

    1992-01-01

    Numerical solutions to the two-fermion bound-state problem in the (1+1)-dimensional Yukawa model are presented within the lowest-order light-front Tamm-Dancoff approximation (i.e., keeping only two-fermion and two-fermion--one-boson sectors). Our motivation is twofold. First, we want to understand the dynamics of the model from the very-weak-coupling domain, where the system is governed by nonrelativistic dynamics, to moderate and strong-coupling domains where retardation and self-energy effects become important. Second, we want to develop techniques for solving coupled Tamm-Dancoff integral equations, in particular, methods that can be generalized to higher-order Tamm-Dancoff approximations. To achieve the first goal we first simplify the problem considerably (from a numerical point of view) by the explicit elimination of the higher Fock-space sector. The resulting integral equation, whose kernel depends upon the invariant mass of the state, is solved for the coupling constant, for a given set of the invariant mass and fermion and boson mass parameters. To achieve the second goal we solve the coupled set of equations using both basis functions and direct-discretization techniques. Results from these more general techniques are compared with the explicit-elimination method

  8. The Effect of the Immediate Feedback by the Collaborative Education Tool ViLLE on Learning for Business Mathematics in Higher Education

    Science.gov (United States)

    Kuikka, Matti; Laakso, Mikko-Jussi; Joshi, Marjo

    2016-01-01

    This article outlines the effect of the collaborative educational tool ViLLE when learning business mathematics in higher education. ViLLE validates students' answers during the assessment process and provides immediate feedback, enabling students to receive feedback and guidance about the correctness of their answers. The learning results in the…

  9. [Experiments on the OMEGA Laser System]. LLE Review. Quarterly report, July-September 1985. Volume 24

    International Nuclear Information System (INIS)

    Skupsky, S.

    1985-01-01

    This volume of the LLE Review contains articles on the first 24-beam uv experiments on the OMEGA laser system, the use of absorption spectroscopy to diagnose high-density compressions, the development of a new target fabrication technique to coat mechanically unsupported laser-fusion targets with a parylene layer, the use of liquid crystals as laser-beam apodizers, the investigation of the process of melting using a subpicosecond probe, the development of a new picosecond oscilloscope, and the National Laser Users Facility activities for June-September 1985. 80 refs., 36 figs

  10. Varainhankintatuotteita hyväntekeväisyysjärjestölle

    OpenAIRE

    Syrjäkylä, Iida

    2014-01-01

    Lemmikin asema perheessä ja yhteiskunnassa on muuttunut ja samalla niihin liittyvä kuluttaminen on kasvanut kovaa vauhtia. Eläinten hyvinvointiin kiinnitetään huomiota yhä enemmän globaalilla tasolla. Asenne- ja lakimuutoksia ajavat eläinsuojelu- ja rescuejärjestöt. Eläimiin kohdistuva hyväntekeväisyys on aiheena vanha, mutta muotoilijan näkökulmasta mielenkiintoinen tutkimuskohde. Opinnäytetyön aiheena on varainhankintatuotteen suunnittelu hyväntekeväisyysjärjestölle. Tarkoituksena on...

  11. Sosiaalisen median negatiiviset vaikutukset käyttäjälle

    OpenAIRE

    Vidgren, Lilli

    2018-01-01

    Tutkielma on kirjallisuuskatsauksena toteutettu kandidaatintutkielma, jonka tutkimusaihe ja -otsikko on sosiaalisen median negatiiviset vaikutukset käyttä- jälle. Negatiivisia vaikutuksia tutkittiin vapaa-ajan käytön näkökulmasta. Sosiaalinen media on tullut nopeasti tärkeäksi ja välttämättömäksi osaksi ihmisten jokapäiväistä elämää, ja sen jatkuva läsnäolo vaikuttaa sen käyttäjiin negatiivisella tavalla. Negatiivisten vaikutusten tutkimisella ihmiset tulisivat enemmän tieto...

  12. Digitaalisen markkinoinnin markkinointisuunnitelman kehittäminen yritys X:lle

    OpenAIRE

    Myllynen, Juhopekka

    2016-01-01

    Tämän toiminnallisen opinnäytetyön tavoitteena kehitettiin toimeksiantaja yritys X:lle digi-taalisen markkinoinnin markkinointisuunnitelma, joka pyrkii vuorovaikutukseen kuluttajien ja lähiruokatuottajien kanssa.. Tarkoituksena mahdollistettiin opinnäytetyön tuotoksen hyödyn-täminen toimeksiantajan liiketoimintasuunnitelman kehittämiseksi. Yritys X on lähiruokaan ja uudenlaiseen foodhub toimintamalliin perustuva startup yritys. Opinnäytetyön aikana keskeisenä viitekehyksenä käytettiin läh...

  13. Yritystoiminnan laajentaminen Kissakahvila Purnauskiksessa : opas yrittäjälle

    OpenAIRE

    Lehmus, Ida-Rebecka

    2016-01-01

    Tämä opinnäytetyö on tehty toimeksiantona Kissakahvila Purnauskiksen yrittäjälle, Tiina Aaltoselle. Kissakahvila Purnauskiksen toimintaa aiotaan laajentaa Ouluun, joten työssä keskitytään teemoihin laajennustoimiin liittyen. Työn painopisteen kartoittami-seksi tehtiin alkuselvitys yrittäjän kanssa tämän tarpeista ja toiveista. Päätökset lopulli-sesta laajentamistavasta, aikataulusta ja rahoituskeinoista ovat vielä kesken, joten työn rajaus oli kirjoittajan päätettävissä. Opinnäytetyön tar...

  14. A structural query system for Han characters

    DEFF Research Database (Denmark)

    Skala, Matthew

    2016-01-01

    The IDSgrep structural query system for Han character dictionaries is presented. This dictionary search system represents the spatial structure of Han characters using Extended Ideographic Description Sequences (EIDSes), a data model and syntax based on the Unicode IDS concept. It includes a query...... language for EIDS databases, with a freely available implementation and format translation from popular third-party IDS and XML character databases. The system is designed to suit the needs of font developers and foreign language learners. The search algorithm includes a bit vector index inspired by Bloom...... filters to support faster query operations. Experimental results are presented, evaluating the effect of the indexing on query performance....

  15. Hans-Joachim Schlieben , collector extraordinary

    Directory of Open Access Journals (Sweden)

    O. A. Leistner

    1976-11-01

    Full Text Available Hans-Joachim Eberhardt Schlieben was born in Germany in 1902. Between 1930 and 1935 he collected plants in Tanzania and since 1955 in Southern Africa, on Madagascar, the Mascarenes, the Comoro Islands and the Seychelles. Almost 400 of the approximately 13 000 numbers which he has collected have been described as new.

  16. Obituary: Hans Albrecht Bethe, 1906-2005

    NARCIS (Netherlands)

    Wijers, R.

    2007-01-01

    One of the unquestioned giants of physics and astrophysics, Hans Bethe, died on 6 March 2005, at the venerable age of 98, in his home town of Ithaca, New York. Seven decades of contributing to research and a Nobel Prize for his work on stellar hydrogen burning make a listing of his honors

  17. Hans von Engel and the ICPIG Conference

    International Nuclear Information System (INIS)

    Franklin, R.

    2000-01-01

    The history of the, organized by Hans von Engel, International Conference on Phenomena in Ionized Gases is presented: Oxford (1953), Delft (1955), Venice (1957), Uppsala (1959), Munich (1961), Oxford (1971) and Berlin (1977). Some organizational aspects, financial support and remarkable events like international prizes in field of plasma physics are given

  18. Combined determination of serum type IV collagen with urine Tamm-Horsfall protein and albumin for early diagnosis in diabetic retinopathy

    International Nuclear Information System (INIS)

    Wang Hong; Zhang Aihua; Ren Yuguo

    2003-01-01

    Objective: To study the relationship between changes of serum type IV collagen, urine Tamm-horsfall protein, albumin and development of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. Methods: Serum CIV, urine THP and Alb were determined with ELISA and RIA respectively in 76 patients with type 2 diabetes mellitus (NDR26, BDR26, PDR24) and 30 controls. Results: Values of the three markers were significantly different among the three groups of patients (p < 0.01; p < 0.01; p < 0.001 respectively). Conclusion: Serum type IV collagens, urine Tamm-Horsfall protein and albumin were sensitive indicators in predicting diabetic retinopathy

  19. Erotismo y Música Para La Escena: El Género Sicaliptico: Vicente Lleó Balbestre

    Directory of Open Access Journals (Sweden)

    José Salvador Blasco Magraner

    2015-01-01

    Full Text Available A principios del siglo XX, el género sicalíptico, es decir el erotismo y lo picante, comenzó a invadir los proscenios de aquellos coliseos en donde se representaba el género chico. El compositor valenciano Vicente Lleó Balbastre se convirtió en la figura de referencia de esta modalidad teatral; con obras tan insignes como La Corte de Faraón, opereta bíblica estrenada en 1910 en el teatro Eslava de Madrid,a la sazón el templo de la sicalipsis, y de la que se llegaron a realizar setecientas setenta y dos representaciones. Este artículo investiga la incidencia del género sicalíptico en los escenarios teatrales líricos madrileños a través de la biografía del maestro Vicente Lleó, uno de los máximos exponentes del género chico.

  20. Restricted second random phase approximations and Tamm-Dancoff approximations for electronic excitation energy calculations

    International Nuclear Information System (INIS)

    Peng, Degao; Yang, Yang; Zhang, Peng; Yang, Weitao

    2014-01-01

    In this article, we develop systematically second random phase approximations (RPA) and Tamm-Dancoff approximations (TDA) of particle-hole and particle-particle channels for calculating molecular excitation energies. The second particle-hole RPA/TDA can capture double excitations missed by the particle-hole RPA/TDA and time-dependent density-functional theory (TDDFT), while the second particle-particle RPA/TDA recovers non-highest-occupied-molecular-orbital excitations missed by the particle-particle RPA/TDA. With proper orbital restrictions, these restricted second RPAs and TDAs have a formal scaling of only O(N 4 ). The restricted versions of second RPAs and TDAs are tested with various small molecules to show some positive results. Data suggest that the restricted second particle-hole TDA (r2ph-TDA) has the best overall performance with a correlation coefficient similar to TDDFT, but with a larger negative bias. The negative bias of the r2ph-TDA may be induced by the unaccounted ground state correlation energy to be investigated further. Overall, the r2ph-TDA is recommended to study systems with both single and some low-lying double excitations with a moderate accuracy. Some expressions on excited state property evaluations, such as 〈S ^2 〉 are also developed and tested

  1. Tamm-plasmon and surface-plasmon hybrid-mode based refractometry in photonic bandgap structures.

    Science.gov (United States)

    Das, Ritwick; Srivastava, Triranjita; Jha, Rajan

    2014-02-15

    The transverse magnetic (TM) polarized hybrid modes formed as a consequence of coupling between Tamm plasmon polariton (TM-TPP) mode and surface plasmon polariton (SPP) mode exhibit interesting dispersive features for realizing a highly sensitive and accurate surface plasmon resonance (SPR) sensor. We found that the TM-TPP modes, formed at the interface of distributed Bragg reflector and metal, are strongly dispersive as compared to SPP modes at optical frequencies. This causes an appreciably narrow interaction bandwidth between TM-TPP and SPP modes, which leads to highly accurate sensing. In addition, appropriate tailoring of dispersion characteristics of TM-TPP as well as SPP modes could ensure high sensitivity of a novel SPR platform. By suitably designing the Au/TiO₂/SiO₂-based geometry, we propose a TM-TPP/SPP hybrid-mode sensor and achieve a sensitivity ≥900  nm/RIU with high detection accuracy (≥30  μm⁻¹) for analyte refractive indices varying between 1.330 and 1.345 in 600-700 nm wavelength range. The possibility to achieve desired dispersive behavior in any spectral band makes the sensing configuration an extremely attractive candidate to design sensors depending on the availability of optical sources.

  2. Restricted second random phase approximations and Tamm-Dancoff approximations for electronic excitation energy calculations

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Degao; Yang, Yang; Zhang, Peng [Department of Chemistry, Duke University, Durham, North Carolina 27708 (United States); Yang, Weitao, E-mail: weitao.yang@duke.edu [Department of Chemistry and Department of Physics, Duke University, Durham, North Carolina 27708 (United States)

    2014-12-07

    In this article, we develop systematically second random phase approximations (RPA) and Tamm-Dancoff approximations (TDA) of particle-hole and particle-particle channels for calculating molecular excitation energies. The second particle-hole RPA/TDA can capture double excitations missed by the particle-hole RPA/TDA and time-dependent density-functional theory (TDDFT), while the second particle-particle RPA/TDA recovers non-highest-occupied-molecular-orbital excitations missed by the particle-particle RPA/TDA. With proper orbital restrictions, these restricted second RPAs and TDAs have a formal scaling of only O(N{sup 4}). The restricted versions of second RPAs and TDAs are tested with various small molecules to show some positive results. Data suggest that the restricted second particle-hole TDA (r2ph-TDA) has the best overall performance with a correlation coefficient similar to TDDFT, but with a larger negative bias. The negative bias of the r2ph-TDA may be induced by the unaccounted ground state correlation energy to be investigated further. Overall, the r2ph-TDA is recommended to study systems with both single and some low-lying double excitations with a moderate accuracy. Some expressions on excited state property evaluations, such as 〈S{sup ^2}〉 are also developed and tested.

  3. Temperature-mediated transition from Dyakonov-Tamm surface waves to surface-plasmon-polariton waves

    Science.gov (United States)

    Chiadini, Francesco; Fiumara, Vincenzo; Mackay, Tom G.; Scaglione, Antonio; Lakhtakia, Akhlesh

    2017-08-01

    The effect of changing the temperature on the propagation of electromagnetic surface waves (ESWs), guided by the planar interface of a homogeneous isotropic temperature-sensitive material (namely, InSb) and a temperature-insensitive structurally chiral material (SCM) was numerically investigated in the terahertz frequency regime. As the temperature rises, InSb transforms from a dissipative dielectric material to a dissipative plasmonic material. Correspondingly, the ESWs transmute from Dyakonov-Tamm surface waves into surface-plasmon-polariton waves. The effects of the temperature change are clearly observed in the phase speeds, propagation distances, angular existence domains, multiplicity, and spatial profiles of energy flow of the ESWs. Remarkably large propagation distances can be achieved; in such instances the energy of an ESW is confined almost entirely within the SCM. For certain propagation directions, simultaneous excitation of two ESWs with (i) the same phase speeds but different propagation distances or (ii) the same propagation distances but different phase speeds are also indicated by our results.

  4. Texas, Rosie ja Helga KitKat Clubist : endised varieteestaarid Ülle Toming, Reet Paavel ja Laine Mägi astuvad taas lavale / Ülle Toming, Reet Paavel, Laine Mägi ; interv. Verni Leivak

    Index Scriptorium Estoniae

    Toming, Ülle, 1955-

    2003-01-01

    Vanalinnastuudio muusikal "Cabaret". Intervjuu omaaegsete varieteetähtedega: Laine Mägi, Ülle Toming ja Reet Paavel moodustavad muusikalis "Cabaret" osa koorist, kel tuleb üle hulga aja laulda, tantsida ja näidelda väga erinevates rollides. Lisaks nende tutvustus "Kolm graatsiat"

  5. Lossi legendist, tamme teekonnast ja maali mõistatusest / Alar Läänelaid

    Index Scriptorium Estoniae

    Läänelaid, Alar, 1951-

    2006-01-01

    Dendrokronoloogilisest dateerimisest (aastarõngasdateerimine), mis on toonud selgust Alatskivi lossi söögisaali laekaunistuse dateerimisse, Hans van Esseni maali "Vaikelu homaariga" ning Clara Peetersi "Vaikelu jahisaagiga" valmimisaja ja ehtsuse kindlaksmääramisse

  6. Hans Pöhl - Estlandssvenskarnas hövding = Hans Pöhl - rannarootslaste eestvõitleja / Torkel Jansson

    Index Scriptorium Estoniae

    Jansson, Torkel, 1947-

    2011-01-01

    Raamatututvustus: Hans Pöhl - Estlandssvenskarnas hövding : en biografi över Hans Pöhl (1876-1930), estlandssvenskarnas främste företrädare och ledare = Hans Pöhl - rannarootslaste eestvõitleja : Hans Pöhli (1876-1930), Eesti rootslaste vaimse liidri ja valgustaja elulugu. (Stockholm ; Tallinn, 2010)

  7. Kuidas ühiskondlikus leppes lubatud hea tuntavaks tehakse? / Jaak Aaviksoo, Jüri Tamm, Kaul Nurm...[jt.

    Index Scriptorium Estoniae

    2003-01-01

    Küsimusele "missugune oleks nende panus ja plaan esimese aasta jooksul ühiskondlikus leppes fikseeritud eesmärkide saavutamiseks" vastavad Tartu Ülikooli rektor Jaak Aaviksoo, EOK asepresident Jüri Tamm, Eestimaa Talupidajate Keskliidu peadirektor Kaul Nurm, Eesti Kirikute Nõukogu täitevsekretär Eerik Jõks, Eesti Ühistegelise Liidu juhatuse esimees Urmas Laht, Eesti Väike- ja Keskettevõtjate Assotsiatsiooni juhataja Riina Danilson ning Reformierakonna pressinõunik Peep Lillemägi. Samas ka karikatuur

  8. LLE 1998 annual report, October 1997 -September 1998. Inertial fusion program and National Laser Users' Facility program

    International Nuclear Information System (INIS)

    1999-01-01

    This report summarizes research at the Laboratory for Laser Energetics (LLE), the operation of the National Laser Users' Facility (NLUF), and programs involving the education of high school, undergraduate, and graduate students for FY98. Research summaries cover: progress in laser fusion; diagnostic development; laser and optical technology; and advanced technology for laser targets

  9. Kuidas toetate sel õppeaastal oma valla koolilapsi? / Külle Viks, Helen Metsma, Aivar Surva...[jt.

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Türi vallavalitsuse haridusspetsialist Külle Viks, Sõmerpalu valla lastekaitse ja sotsiaaltoetuste spetsialist Helen Metsma, Mäetaguse vallavanem Aivar Surva, Rapla abivallavanem Imbi Kalberg, Kärdla linna haridusnõunik Juta Alev, Albu vallavalitsuse sotsiaalnõunik Claire Miljukova, Võru linnavalitsuse haridusspetsialist Kristi Aavakivi

  10. Adamson-Eric 100 : XX sajandi kunsti- ja kultuurilugu ühe inimsaatuse kaudu / Ülle Kruus

    Index Scriptorium Estoniae

    Kruus, Ülle

    2002-01-01

    Näitus "Adamson-Eric 100" Eesti Kunstimuuseumi Rüütelkonna hoones ja Adamson-Ericu muuseumis. Koostajad Ülle Kruus, Kersti Koll, Hanno Soans, kujundajad Leonhard Lapin (EKM), Jaak Soans (Adamson-Ericu muuseum). Adamson-Ericu teosed väljaspool Eestit ja Eestisse tagasi jõudnud tööd

  11. LLE 1998 annual report, October 1997--September 1998. Inertial fusion program and National Laser Users` Facility program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    This report summarizes research at the Laboratory for Laser Energetics (LLE), the operation of the National Laser Users` Facility (NLUF), and programs involving the education of high school, undergraduate, and graduate students for FY98. Research summaries cover: progress in laser fusion; diagnostic development; laser and optical technology; and advanced technology for laser targets.

  12. Mida teie oma tervise heaks teete? / Ly Jagor, Ülle Mihhailova, Ene Pill, Katrin Käbin...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Pärnu Õppenõustamiskeskuse psühholoog Ly Jagor, Maasika lasteaia juhataja asetäitja Ülle Mihhailova, Tallinna Perekeskuse ja Tähetorni lastekeskuse psühholoog Ene Pill, Tallinna Nõmme Noortemaja väikelaste ringijuht Katrin Käbin, Tääksi Põhikooli õpetaja Silva Kolk

  13. [Integrated health service research of the epiphenomenon (IVF-E)--paradigm shift or Dölle's wine in new skins?].

    Science.gov (United States)

    Herzog, Wolfgang

    2011-08-01

    The meaning of epiphenomenalism for psychosomatic medicine and psychotherapy is analyzed. It may be concluded that Ernst-August Dölle was one of the first researchers to describe and to use the Alpha and Omega of epiphenomenalism. Georg Thieme Verlag KG Stuttgart · New York.

  14. Hans Teiv : mina sellel kohal igavuse üle ei kurda / Hans Teiv ; interv. Heli Salong

    Index Scriptorium Estoniae

    Teiv, Hans

    2004-01-01

    Saare maavanema kohusetäitja ja kandidaat Hans Teiv hindab oma võimalusi saada ametisse kinnitatud, räägib oma tegevusest maavalitsuse osakonnajuhataja ja maakonna juhina ning tutvustab Saaremaa arenguvisioone

  15. Hans Lepp : ainult tänu kodueestlastele on Eesti olemas / Hans Lepp ; interv. Kalev Vilgats

    Index Scriptorium Estoniae

    Lepp, Hans, 1950-

    2007-01-01

    Rootsi instituudi praegune kultuurinõunik Hans Lepp töötas esimese kultuuriatasheena taas avatud Rootsi suursaatkonnas. Töötamisest Rootsi instituudis, riigi välispoliitikast, suhetest Venemaaga, aprillisündmustest jm

  16. Hans Viertler: professor, cientista, gestor e amigo Hans Viertler: professor, scientist, manager and friend

    Directory of Open Access Journals (Sweden)

    Jailson B. de Andrade

    2010-01-01

    Full Text Available Hans Viertler, a visionary, an example of institutional commitment, a great scientist, excellent and dedicated teacher, highly respected as a professional and admired for his leadership, wisdom, generosity, good humor, professional capacity, and balance. A life dedicated to the consolidation of Chemistry in Brazil, the teaching chemistry, the IQ-USP, the Brazilian Chemical Society (SBQ and the CRQ-fourth region. Hans, a friend with a heart bigger than himself!

  17. JONAS, HANS, Memorias. Por Juan Arana

    Directory of Open Access Journals (Sweden)

    Juan Arana

    2012-05-01

    Full Text Available Autor: Hans Jonas (2005. Editorial: Losada, Madrid. Traducción: Illana Giner Comín. Basadas en las conversaciones con Rachel Salamander. Proemiode Lore Jonas. Prólogo de Rachel Salamander. Editor: Christian Wiese. Hans Jonas forma parte, con Koestler,Popper, Heidegger o Wittgenstein, del selecto grupo de pensadores y escritores a quienes tocó vivir en primera persona gran parte de las peripecias del turbulento siglo XX. Pero, como en todo, hay diferencias.La trayectoria vital de Jonas no dibuja el perfil de una desmesura excéntrica, como la de Wittgenstein, ni de una tenaz ambición teórica, como la de Popper, ni de un lamentable olvido del prójimo, como la de Heidegger, ni de un aventurismo desquiciado, como la de Koestler.

  18. Transforming han: a correlational method for psychology and religion.

    Science.gov (United States)

    Oh, Whachul

    2015-06-01

    Han is a destructive feeling in Korea. Although Korea accomplished significant exterior growth, Korean society is still experiencing the dark aspects of transforming han as evidenced by having the highest suicide rate in Asia. Some reasons for this may be the fragmentation between North and South Korea. If we can transform han then it can become constructive. I was challenged to think of possibilities for transforming han internally; this brings me to the correlational method through psychological and religious interpretation. This study is to challenge and encourage many han-ridden people in Korean society. Through the psychological and religious understanding of han, people suffering can positively transform their han. They can relate to han more subjectively, and this means the han-ridden psyche has an innate sacredness of potential to transform.

  19. Hans Strahl's pioneering studies in comparative placentation

    DEFF Research Database (Denmark)

    Carter, Anthony Michael; Mess, A

    2010-01-01

    Hans Strahl, a contemporary of Duval and Hubrecht, made many important contributions to comparative placentation. Despite this he is not well known and some of his original observations tend to be attributed to later authors. Strahl published a classification of placental types based on their shape...... of the most important findings made by Strahl including work on placentation in carnivores and higher primates that remains unsurpassed....

  20. Uudised : Depeche Mode'i maailmaturnee peaaegu välja müüdud. Easy Listening esitleb : Villu Tamme diskorina

    Index Scriptorium Estoniae

    2001-01-01

    Ans. Depeche Mode maailmaturnee "Exciter" Euroopa ja Ameerika kontserdid on peaaegu välja müüdud. 11. mail KuKu klubis toimuval muusikapeol sarjas 'The Easy Listening Sessions' astub diskorina üles V.Tamme

  1. Toetuseta jäämine šokeeris mainekat kultuuriajakirja / Ott Raun, Laine Jänes ; interv. Rebekka Lotman ; komment. Marek Tamm

    Index Scriptorium Estoniae

    Raun, Ott, 1940-

    2009-01-01

    Eesti Kultuurkapitalinõukogu otsusel jääb ajalookultuuri ajakiri "Tuna" alates 2009. aastast püsitoetusest ilma. Sellega seotud küsimustele vastavad "Tuna" peatoimetaja Ott Raun ja Eesti Kultuurkapitali nõukogu esimees Laine Jänes, kommenteerinud ajaloolane Marek Tamm

  2. Jüri Tamm: vaid osaledes on võimalik silma vaadata ja mõista oksjoni mõtet / toimetanud Kristi Vahemaa

    Index Scriptorium Estoniae

    Tamm, Jüri, 1937-

    2011-01-01

    Oksjoni idee autor ja korraldaja Jüri Tamm 4.12.2011 toimuvast 12. heategevuslikust kunstioksjonist, mille tulud lähevad hukkunud sportlaste laste toetuseks. Tänavune väliskülaline on kõrgushüppaja Dick Fosbury. Müügile tulevate taieste nimekiri. Tagasivaade oksjonitele. Koostööd tehakse galeriiga Rios

  3. Regionality and biotope exploitation in Danish Ertebølle and adjoining periods

    DEFF Research Database (Denmark)

    Enghoff, Inge Bødker

    .g., the introduction of domestic animals at the transition to the Neolithic (Funnel Beaker Culture). Highlights among new results include the identification of exotic species, specialisations in fishing and hunting at the level of regions and individual settlements, temporal size-changes of red deer, extinction......Abstract Results from new analyses of eleven newly excavated animal bone assemblages from settlements in four regions in Stone Age Denmark (Vendsyssel, the Limfjord area, East Central Jutland and Northern Zealand) are presented and discussed together with reviews of previously studied bone...... assemblages. Most of the settlements date from the Ertebølle culture (5400-3950 BC), but some include the preceding late Kongemose culture as well, while others extend into the Neolithic Funnel Beaker Culture. The study focuses on exploitation of marine and terrestrial animal resources and early animal...

  4. LLE Quarterly Report (July-September 1999)[Library for Laser Energetics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-01-07

    This volume of the LLE Review, covering the period July-September 1999, features a theoretical analysis of a process that generates mass perturbations of an imploding target driven by modulated laser illumination. The process, referred to as laser imprint, impacts the integrity of the shell during direct-drive implosions, potentially quenching target performance. In this article V. N. Goncharov, J. A. Delettrez, S. Skupsky, and R. P. J. Town present a model of the generation of mass perturbations and analyze the mass perturbation growth due to nonuniform ablation pressure. Stabilizing mechanisms of thermal conduction smoothing and mass ablation are shown to suppress the acceleration perturbation, and mass ablation is also shown to impact velocity perturbations. The model predicts that a direct-drive cryogenic NIF target will remain intact during the implosion when l-Thz SSD beam smoothing is used.

  5. Käyttöohjeen tuottaminen kalataloushallinnon Kaveri-tietojärjestelmälle

    OpenAIRE

    Härkönen, Eevamaria

    2011-01-01

    Tämän opinnäytetyön aiheena oli suunnitella ja tuottaa käyttöohjeet kalataloushallinnon tietojärjestelmälle, joka on kehitetty maa- ja metsätalousministeriön tietopalvelukeskuksessa Tikessä. Käyttöohje laadittiin opintoihin kuuluneen syventävän harjoittelun yhteydessä. Kyseisestä kalataloushallinnon tietojärjestelmästä käytetään kutsumanimeä Kaveri. Vapaa-ajan kalatalouteen liittyvä Kaveri-tietojärjestelmä on laaja ja moniosainen järjestelmä, joka sisältää muun muassa velvoite-, istutus- sekä...

  6. Cadmium toxicity studies under long term-low level exposure (LLE) conditions. I

    International Nuclear Information System (INIS)

    Sabbioni, E.; Marafante, E.; Amantini, L.; Ubertalli, L.; Pietra, R.

    1978-01-01

    A long term-low level exposure (LLE) experiment was conducted on rats to determine the metabolic patterns for realistic dietary levels of cadmium. Male rats fed with 61 ppb of cadmium ad libitum, 50 labelled with 109 Cd radiotracer as cadmium chloride via drinking mineral water and 11 unlabelled via food for 2 years. The diet was characterized in its metal content by neutron activation analysis to obtain the total dietary intake of different elements. The kidney was found to be the tissue with the major concentration of cadmium which accumulated continuously during the experiment. The variation of the accumulation pattern of Cd concentration in the liver and intestine indicated an initial rapid increase of Cd during the first 100 days. After this period an apparent equilibrium was attained in both these tissues until the end of the study. The intracellular distribution of cadmium in kidneys, liver, intestine and pancreas were similar, the cytosol fractions containing about 80% of the cellular cadmium. Dialysis experiments indicated that significant amounts of cadmium were able to be associated with cellular organelles, the mitochondria representing the most important organelle capable of binding cadmium. The cytoplasmatic Cd-profiles obtained at various stages of the experiment showed that the metal was only bound to a low-molecular-weight component, cadmium-binding protein (CdBP), which represents the specific cellular-binding component for cadmium under the long term-low level exposure (LLE) conditions. No significant variations in the concentrations of the elements in different organs were observed in animals supplemented with 109 Cd in respect to 109 Cd untreated controls. (Auth.)

  7. [Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia. Hrsg. von Marek Tamm, Linda Kaljundi, Carsten Selch Jensen] / Volker Honemann

    Index Scriptorium Estoniae

    Honemann, Volker, 1943-

    2013-01-01

    Arvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia. Hrsg. von Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Verlag Ashgate. Farnham, 2011

  8. The philosophy of Hans-Georg Gadamer / Wolfgang Drechsler

    Index Scriptorium Estoniae

    Drechsler, Wolfgang, 1963-

    1998-01-01

    Rets.rmt.: The philosophy of Hans-Georg Gadamer : a review of the philosophy of Hans-Georg Gadamer / Lewis Edwin Hahn, ed. Chicago and La Salle, IL: Open Court, 1997. (The Library of Living Philosophers, vol. XXIV)

  9. Kohvik-restorani Cést La Vie sisekujundus. Tallinn, Suur-Karja 5 / Maile Grünberg, Tõnis Vellama, Ülle Rajasalu

    Index Scriptorium Estoniae

    Grünberg, Maile, 1942-

    2008-01-01

    2 korruse plaani, 8 värv. vaadet; fotod: Ingmar Muusikus; sisearhitekt M. Grünberg kavandas ka valdavalt mööbli, laevalgusti disainis T. Vellama, skulptuuride (koopiad) autor on keraamik Ülle Rajasalu

  10. Rannarootslaste suurmees Hans Pöhl / Olev Liivik

    Index Scriptorium Estoniae

    Liivik, Olev, 1975-

    2011-01-01

    Arvustus: Estlandssvenskarnas hövding. En biografi över Hans Pöhl (1876-1930), estlandssvenskarnas främste företrädare och ledare = Hans Pöhl - rannarootslaste eestvõileja : Hans Pöhl (1876-1930), Eesti rootslaste vaimse liidri ja valgustaja elulugu. Stockholm, 2010

  11. Reações hansênicas do tipo 1 e eritema nodoso hansênico

    OpenAIRE

    Kahawita, Indira P.; Walker, Stephen L.; Lockwood, Diana N.J.

    2008-01-01

    Leprosy reactions are a major cause of nerve damage and morbidity in a significant proportion of leprosy patients. Reactions are immunologically mediated and can occur even after successful completion of multi-drug therapy. This review focuses on the epidemiology, pathology and treatment of leprosy type 1 reactions, erythema nodosum leprosum and silent neuropathy. As reações hansênicas são a principal causa de dano e morbidade neural em grande parte dos pacientes hansênicos. São imunomedia...

  12. MTÜ Setomaa Turism eestvedaja Ülle Pärnoja: kõige olulisem on suure pildi nägemise oskus / intervjueerinud Annela Laaneots

    Index Scriptorium Estoniae

    Pärnoja, Ülle

    2015-01-01

    Intervjuu Ülle Pärnojaga, kelle juhitav MTÜ Setomaa Turism sai Seto Külävüü kostipäeva ehk kodukohvikute päeva eest Setomaal Põlvamaa aasta turismi-/turundusteo 2014 tiitli, Ülle Pärnoja sai tiitli Põlvamaa 2014. aasta turismitöötaja. Kostipäeva korraldamisest ja turunduskommunikatsioonist, Setomaa turismikommunikatsioonist. Obinitsa Setomaal on soome-ugri kultuuripealinn 2015, toimuvatest üritustest

  13. Tülikas meediademokraat Hans H. Luik / Hans H Luik ; interv. Jaanika Merilo

    Index Scriptorium Estoniae

    Luik, Hans H., 1961-

    2006-01-01

    Ekspress Grupi omanik ja nõukogu liige Hans H. Luik vastab küsimustele, mis puudutavad Ekspress Grupi võimlikku börsile minekut, meediaportfelli laiendamist ning tema vastu suunatuid rünnakuid. Skeem: Ekspress Grupp. Tabelid: Eesti Ekspressi majandusnäitajad; Ekspress Grupi majandusnäitajad. Kommenteerivad: Tuomas Siltala, Karoly Kirber, Lauri Lind ja Peeter Koppel

  14. Group-theoretical deduction of a dyadic Tamm-Dancoff equation by using a matrix-valued generator coordinate

    International Nuclear Information System (INIS)

    Nishiyama, Seiya; Morita, Hiroyuki; Ohnishi, Hiromasa

    2004-01-01

    The traditional Tamm-Dancoff (TD) method is one of the standard procedures for solving the Schroedinger equation of fermion many-body systems. However, it meets a serious difficulty when an instability occurs in the symmetry-adapted ground state of the independent particle approximation (IPA) and when the stable IPA ground state becomes of broken symmetry. If one uses the stable but broken symmetry IPA ground state as the starting approximation, TD wave functions also become of broken symmetry. On the contrary, if we start from a symmetry-adapted but unstable wave function, the convergence of the TD expansion becomes bad. Thus, the requirements of symmetry and rapid convergence are not in general compatible in the conventional TD expansion of the systems with strong collective correlations. Along the same line as Fukutome's, we give a group-theoretical deduction of a U(n) dyadic TD equation by using a matrix-valued generator coordinate

  15. Non-Toxic HAN Monopropellant Propulsion, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Non-toxic monopropellants have been developed that provide better performance than toxic hydrazine. Formulations based on hydroxylammonium nitrate (HAN) have...

  16. [Hans Jonas: Nature Conservation, Conservation of Life].

    Science.gov (United States)

    Burgui Burgui, Mario

    2015-01-01

    This article discusses three of the problems that the German philosopher Hans Jonas studied. The first one addresses the need for a specific ethic dedicated to the moral dimension of environmental problems, from a different perspective to the traditional. The second problem is crucial in the discussion on environmental ethics: the value of the nature. Does the nature have an intrinsic value or an instrumental value only (to satisfy the interests of the human being)? The thesis of Jonas, which claimed that nature is a good in itself, were further elaborated here. And the third problem is the derivation of moral norms and the role of man in this ethic that recognizes a good in itself in nature. According to Jonas, the human being is not diminished by recognizing the intrinsic value of nature, since the man's uniqueness and value are unquestionable. From these three central issues, the paper highlights the importance of seeking the links between bioethics and environmental ethics to address the current environmental, social and economic crisis.

  17. Obituary: Hans Albrecht Bethe, 1906-2005

    Science.gov (United States)

    Wijers, Ralph

    2007-12-01

    One of the unquestioned giants of physics and astrophysics, Hans Bethe, died on 6 March 2005, at the venerable age of 98, in his home town of Ithaca, New York. Seven decades of contributing to research and a Nobel Prize for his work on stellar hydrogen burning make a listing of his honors superfluous (besides being impossible in this space). Bethe was born in Strassburg, in then German Alsass Lothringen, on 2 July 1906. His father, Albrecht Julius Bethe (1872-1954), taught physiology at the University, and his mother, Anna Kuhn (1876-1966), was a musician and writer. Both his grandfathers were physicians. He spent his youth in Strassburg, Kiel, and Frankfurt, and some time in sanatoria due to tuberculosis. Hans's first scientific paper, at age 18, was with his father and a colleague, on dialysis. His education and early career in Germany brought him into contact with many top stars in the quantum revolution. Starting in Frankfurt in chemistry, Bethe soon switched to physics, taught there by Walter Gerlach and Karl Meissner, among others. In 1926, he successfully applied to join Arnold Sommerfeld's group in Munich, where he met one of his later long-term collaborators, Rudolf Peierls. Bethe considered his entry into physics to have come at an ideal time, with the new ideas of wave mechanics being developed and discussed right there; it was certainly also at an ideal place. His doctoral thesis was on the theory of electron diffraction by crystals, following the experimental work by Clinton Davisson and Lester Germer and the work on X-ray diffraction by Max von Laue and Paul Ewald. The newly minted doctor went from there briefly to Frankfurt and then to Ewald in Stuttgart, where he felt at home academically and personally. In 1939, Bethe would marry Ewald's daughter Rose. Not much later, though, Sommerfeld recalled him to Munich, where Sommerfeld created a Privatdozent position for him. There he worked out the solution for a linear chain of coupled spins by what we

  18. Hans Kelsen: pensador político

    Directory of Open Access Journals (Sweden)

    Sara Lagi

    2011-01-01

    Full Text Available Hasta la publicación de Sobre la esencia y el valor de la democracia, Hans Kelsen era solo conocido como experto en derecho público. El valor de este artículo de Lagi radica en rescatar de la obra kelseniana un aspecto casi por completo olvidado por la crítica, a saber, sus análisis sobre el significado y las características de la democracia parlamentaria en los Estados modernos. Se aborda la cuestión no solo desde el debate teórico sino también desde su contexto histórico¿político. La teoría política de Kelsen es considerada una parte integral de su doctrina central, presentada en Teoría pura del derecho, su obra más conspicua. Un análisis del trabajo sobre la esencia y el valor de la democracia nos restituye la imagen de un Kelsen como original pensador político. Se analizan las dos ediciones de Sobre la esencia y el valor de la democracia (1920¿1929 con estos propósitos: comprender por qué decidió dedicarse a la teoría de la democracia un teórico que rigurosamente defendió la separación de la esfera jurídica respecto de la historia, la filosofía y la política; y por qué no se limitó a explicar la esencia de la democracia sino que decidió concentrarse en clarificar qué se entiende por valor de la democracia.

  19. Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): comparison of the performance in classification of ecstasy tablets. Part 2.

    Science.gov (United States)

    Bonadio, Federica; Margot, Pierre; Delémont, Olivier; Esseiva, Pierre

    2008-11-20

    Headspace solid-phase microextraction (HS-SPME) is assessed as an alternative to liquid-liquid extraction (LLE) currently used for 3,4-methylenedioxymethampethamine (MDMA) profiling. Both methods were compared evaluating their performance in discriminating and classifying samples. For this purpose 62 different seizures were analysed using both extraction techniques followed by gas chromatography-mass spectroscopy (GC-MS). A previously validated method provided data for HS-SPME, whereas LLE data were collected applying a harmonized methodology developed and used in the European project CHAMP. After suitable pre-treatment, similarities between sample pairs were studied using the Pearson correlation. Both methods enable to distinguish between samples coming from the same pre-tabletting batches and samples coming from different pre-tabletting batches. This finding emphasizes the use of HS-SPME as an effective alternative to LLE, with additional advantages such as sample preparation and a solvent-free process.

  20. A free-volume modification of GEM-QC to correlate VLE and LLE in polymer solutions

    International Nuclear Information System (INIS)

    Radfarnia, H.R.; Taghikhani, V.; Ghotbi, C.; Khoshkbarchi, M.K.

    2004-01-01

    The generalized quasi-chemical (GEM-QC) model proposed by Wang and Vera is modified to correlate better the phase equilibrium and to overcome the shortcoming of the original model to predict the lower critical solution temperature (LCST) of binary polymer solutions. This shortcoming is mainly because the GEM-QC model does not consider the effect of free-volume, which is important in systems containing molecules with large size differences. The proposed modification is based on replacing the combinatorial term of the GEM-QC model by a term proposed by Kontogerogis et al., which includes the effect of the free-volume. The main advantage of the free volume generalized quasi-chemical (GEM-QC-FV) model over the original GEM-QC is its ability to predict the phase behaviour of binary polymer solutions with LCST behaviour. In addition, the free volume UNIQUAC (UNIQUAC-FV) model is used to correlate VLE and LLE experimental data for binary polymer solutions. The comparison of the results obtained from the GEM-QC-FV model and the UNIQUAC-FV model shows the superiority of the GEM-QC-FV model in correlating the VLE and LLE experimental data for binary polymer solutions

  1. han /Smoke in the Context Verse 10 of Sura ad - Duk han

    Directory of Open Access Journals (Sweden)

    Gökhan ATMACA

    2015-07-01

    Full Text Available Holy Qur’an is the last book was sent to mankind as guidance. Prophet has notified the Qur’an. This is because the task for him. He also explained the Qur’an. Companions of the Prophet are appealed to the Prophet when they do not understand the issue. After the Prophet’s death continued activities to understand the Qur’an. For this reason, efforts have been made to understand the Qur’an. It is also written with commentary that explains the verse. There are various opinions on the books of taf sir about the meaning of the verse. Each commentators have described the verse based on their knowledge and understanding. They were found in the preferences among the various opinions. Mufessir sometimes unanimously agreed on the meaning of the verse. Som etimes opinions are different. One of the verse is that the variety of opinions about the 10th verse of Surah ad - Dukhan. Translation of the verse is: “ Then watch thou for the Day that the sky will bring forth a kind of smoke (or mist/ Dûhan plainly visible . ” There are various opinions about what the words mean the smoke/ Dûhan . There are still various views on this incident when or where when. There are several proofs for each view. There are three views about the smoke. According to the first view is from the stink of smoke signals. Therefore, this event has not yet occurred. According to the second opinion. The Prophet prayed against Meccan unbelievers. There famine occurred. As a result, they were subjected to fasting. They start seeing smoke because of h unger. According to a third opinions. Smoke appeared on the day of the conquest of Mecca. Because that day a rising dust set, and covered the sky in the form of smoke .

  2. Mutant tamm-horsfall glycoprotein accumulation in endoplasmic reticulum induces apoptosis reversed by colchicine and sodium 4-phenylbutyrate.

    Science.gov (United States)

    Choi, Sung Won; Ryu, Ok Hee; Choi, Sun Jin; Song, In Sun; Bleyer, Anthony J; Hart, Thomas C

    2005-10-01

    As a consequence of uromodulin gene mutations, individuals develop precocious hyperuricemia, gout, and progressive renal failure. In vitro studies suggest that pathologic accumulation of uromodulin/Tamm-Horsfall glycoprotein (THP) occurs in the endoplasmic reticulum (ER), but the pathophysiology of renal damage is unclear. It was hypothesized that programmed cell death triggered by accumulation of misfolded THP in the ER causes progressive renal disease. Stably transfected human embryonic kidney 293 cells and immortalized thick ascending limb of Henle's loop cells with wild-type and mutated uromodulin cDNA were evaluated to test this hypothesis. Immunocytochemistry, ELISA, and deglycosylation studies indicated that accumulation of mutant THP occurred in the ER. FACS analyses showed a significant increase in early apoptosis signal in human embryonic kidney 293 and thick ascending limb of Henle's loop cells that were transfected with mutant uromodulin constructs. Colchicine and sodium 4-phenylbutyrate treatment increased secretion of THP from the ER to the cell membrane and into the culture media and significantly improved cell viability. These findings indicate that intracellular accumulation of THP facilitates apoptosis and that this may provide the pathologic mechanism responsible for the progressive renal damage associated with uromodulin gene mutations. Colchicine and sodium 4-phenylbutyrate reverse these processes and could potentially be beneficial in ameliorating the progressive renal damage in uromodulin-associated kidney diseases.

  3. Estlandse uithaal naar oud-ambassadeur / Hans Jacobs

    Index Scriptorium Estoniae

    Jacobs, Hans

    2008-01-01

    Hollandi ajakirjanikud küsisid president Toomas Hendrik Ilveselt arvamust endise Hollandi suursaadiku Hans Glaubitzi tagakiusamise kohta. Eestis visiidil olnud Hollandi kuninganna Beatrix'i ja president Toomas Hendrik Ilvese kohtumisest

  4. Population structure of Han nationality in Central-Southern China.

    Science.gov (United States)

    Liu, Qiu-Ling; Chen, Ye-Fei; He, Xin; Shi, Yan-Wei; Wu, Wei-Wei; Zhao, Hu; Lu, De-Jian

    2017-07-01

    Knowledge of population structure is very important for forensic genetics. However, the population substructure in Central-Southern China Han nationality has still not been fully described. In this study, we investigated the genetic diversity of 15 forensic autosomal STR loci from 6879 individuals in 12 Han populations subdivided by administrative provinces in Central-Southern China. The statistical analysis of genetic variation showed that genetic differentiation among these populations was very small with a F st value of 0.0009. The Discriminant Analysis of Principal Components (DAPC) showed that there were no obvious population clusters in Central-Southern China Han population. In practice, the population structure effect in Central-Southern China Han population can be negligible in forensic identification and paternity testing. Copyright © 2017. Published by Elsevier B.V.

  5. Profanum et Promissio : het begrip wereld in de missionaire ecclesiologieën van Hans Hoekendijk, Hans Jochen Margull en Ernst Lange

    NARCIS (Netherlands)

    Petter, Frank Anthonie

    2002-01-01

    Profanum et Promissio The concept of ‘world’ in the missionary ecclesiologies of Hans Hoekendijk, Hans Jochen Margull and Ernst Lange. This study deals with the concept of ‘world’ in the missionary ecclesiologies of Hans Hoekendijk (1912-1975), Hans Jochen Margull (1925-1982) and Ernst Lange

  6. Children and Moods in Hans Christian Andersen's Travel Books

    DEFF Research Database (Denmark)

    Jensen, Lars Bo

    2008-01-01

    A categorization of moods, atmospheres and motifs connected with the children in Hans Christian Andersen’s five travel books (1831-1868). Surprisingly, death and darkness and, on the other side, eroticism and (red) light are the dominant two categories.......A categorization of moods, atmospheres and motifs connected with the children in Hans Christian Andersen’s five travel books (1831-1868). Surprisingly, death and darkness and, on the other side, eroticism and (red) light are the dominant two categories....

  7. The psychoanalytic process in the treatment of Little Hans.

    Science.gov (United States)

    Bierman, Joseph S

    2007-01-01

    This paper studies the psychoanalytic process in the treatment of Little Hans, using Samuel Abrams's 1988 paper in which he defines the psychoanalytic process as the sequence of steps which appears within the mind of the patient as the treatment proceeds. As with the adult, the child can affectively recall or reenact the past in the transference, but the child also tries to promote whatever developmental phase is being clocked in. In January 1908 Max Graf, Hans's father and a member of the Vienna Psychoanalytic Society who was a musicologist, wrote Freud that his son had developed a fear that a horse would bite him in the street. Freud first suggested that the father give his son some enlightenment in the matter of sexual knowledge, such as his mother and other females have no "widdlers." The enlightenments only increased Hans's anxiety, prompting Freud to meet with Hans and his father and interpret the fear of the horse as fear of the father. While Max Graf was able to help Hans understand some dreams and fantasies, he exhibited a punitive attitude toward Hans's masturbation, which was reinforced by Freud's attitude that it was harmful. The father did not promote his son's development when he withheld knowledge of how babies are born, neither did Freud when he withheld any contrary suggestions from the father.

  8. [Stat-kyrka-samhälle : Den stormaktstida samhällsordningen i Sverige och Östersjöpinserna] / Enn Küng

    Index Scriptorium Estoniae

    Küng, Enn, 1963-

    2002-01-01

    Arvustus: Stat-kyrka-samhälle : Den stormaktstida samhällsordningen i Sverige och Östersjöpinserna. (Acta Universitatis Stockholmiensis Studia Baltica Stockholmiensa, 21). Stockholm, 2000. Stockholmi Ülikooli Balti Uuringute Keskuse teaduslik väljaanne "Riik-kirik-ühiskond" Rootsi suurriigi provintsipoliitikast Eesti- ja Liivimaal 16.-17. sajandil

  9. Development of HAN-based Liquid Propellant Thruster

    Science.gov (United States)

    Hisatsune, K.; Izumi, J.; Tsutaya, H.; Furukawa, K.

    2004-10-01

    Many of propellants that are applied to the conventional spacecraft propulsion system are toxic propellants. Because of its toxicity, considering the environmental pollution or safety on handling, it will be necessary to apply the "green" propellant to the spacecraft propulsion system. The purpose of this study is to apply HAN based liquid propellant (LP1846) to mono propellant thruster. Compared to the hydrazine that is used in conventional mono propellant thruster, HAN based propellant is not only lower toxic but also can obtain higher specific impulse. Moreover, HAN based propellant can be decomposed by the catalyst. It means there are the possibility of applying to the mono propellant thruster that can leads to the high reliability of the propulsion system.[1],[2] However, there are two technical subjects, to apply HAN based propellant to the mono propellant thruster. One is the high combustion temperature. The catalyst will be damaged under high temperature condition. The other is the low catalytic activity. It is the serious problem on application of HAN based propellant to the mono propellant thruster that is used for attitude control of spacecraft. To improve the catalytic activity of HAN based propellant, it is necessary to screen the best catalyst for HAN based propellant. The adsorption analysis is conducted by Monte Carlo Simulation to screen the catalyst metal for HAN and TEAN. The result of analysis shows the Iridium is the best catalyst metal for HAN and TEAN. Iridium is the catalyst metal that is used at conventional mono propellant thruster catalyst Shell405. Then, to confirm the result of analysis, the reaction test about catalyst is conducted. The result of this test is the same as the result of adsorption analysis. That means the adsorption analysis is effective in screening the catalyst metal. At the evaluating test, the various types of carrier of catalyst are also compared to Shell 405 to improve catalytic activity. The test result shows the

  10. Binary and ternary LLE data of the system (ethylbenzene + styrene + 1-ethyl-3-methylimidazolium thiocyanate) and binary VLE data of the system (styrene + 1-ethyl-3-methylimidazolium thiocyanate)

    International Nuclear Information System (INIS)

    Jongmans, Mark T.G.; Schuur, Boelo; Haan, André B. de

    2012-01-01

    Highlights: ► LLE data have been measured for the system {ethylbenzene + styrene + [EMIM][SCN]}. ► VLE was determined for the system {styrene + [EMIM][SCN]} at vacuum conditions. ► All experimental data were correlated well with the NRTL model. ► [EMIM][SCN] has a much larger selectivity than the benchmark solvent sulfolane. - Abstract: The distillation of close boiling mixtures may be improved by adding a proper affinity solvent, and thereby creating an extractive distillation process. An example of a close boiling mixture that may be separated by extractive distillation is the mixture ethylbenzene/styrene. The ionic liquid 1-ethyl-3-methylimidazolium thiocyanate ([EMIM][SCN]) is a promising solvent to separate ethylbenzene and styrene by extractive distillation. In this study, (vapour + liquid) equilibrium data have been measured for the binary system (styrene + [EMIM][SCN]) over the pressure range of (3 to 20) kPa and binary and ternary (liquid + liquid) equilibrium data of the system (ethylbenzene + styrene + [EMIM][SCN]) at temperatures (313.2, 333.2 and 353.2) K. Due to the low solubility of ethylbenzene in [EMIM][SCN], it was not possible to measure accurately VLE data of the binary system (ethylbenzene + [EMIM][SCN]) and of the ternary system (ethylbenzene + styrene + [EMIM][SCN]) using the ebulliometer. Because previous work showed that the LLE selectivity is a good measure for the selectivity in VLE, we determined the selectivity with LLE. The selectivity of [EMIM][SCN] to styrene in LLE measurements ranges from 2.1 at high styrene raffinate purity to 2.6 at high ethylbenzene raffinate purity. The NRTL model can properly describe the experimental results. The rRMSD in temperature, pressure and mole fraction for the binary VLE data are respectively (0.1, 0.12 and 0.13)%. The rRMSD is only 0.7% in mole fraction for the LLE data.

  11. Ternary and binary LLE measurements for solvent (2-methyltetrahydrofuran and cyclopentyl methyl ether) + furfural + water between 298 and 343 K

    International Nuclear Information System (INIS)

    Männistö, Mikael; Pokki, Juha-Pekka; Fournis, Ludivine; Alopaeus, Ville

    2017-01-01

    Highlights: • Novel LLE of 2-methyltetrahydrofuran or cyclopentyl methyl ether + furfural + water. • High performance solvents for liquid-liquid extraction exhibited. • Modelled with UNIQUAC-HOC activity coefficient model. • Comparison to other industrial solvents with distribution coefficient and selectivity. - Abstract: The suitability of two solvents for the extraction of furfural from aqueous streams is assessed through novel ternary and binary liquid-liquid equilibria data for mixtures of solvent (2-methyltetrahydrofuran or cyclopentyl methyl ether) + furfural + water. The measured data are reported along with regressed binary interaction parameters for UNIQUAC-HOC activity coefficient model and further analyzed through distribution coefficients and selectivity for furfural. Out of the two solvents, cyclopentyl methyl ether presents a very high selectivity along with good distribution coefficient in the entire temperature range.

  12. Management of radioactive waste at Novi Han Repository

    International Nuclear Information System (INIS)

    Stefanova, I.G.; Mateeva, M.D.; Milanov, M.V.

    2002-01-01

    The Novi Han Repository is the only existing repository in Bulgaria for the disposal of radioactive waste from nuclear applications in industry, medicine and research. The repository was constructed in the early sixties according to the existing requirements. It was operated by the Institute for Nuclear Research and Nuclear Energy for more than thirty years without any accident or release of radioactivity to the environment, but without any investment for upgrading. As a consequence, the Bulgarian Nuclear Safety Authority temporarily stopped the operation of the repository in 1994. The measures for upgrading the Novi Han Repository, supported by the IAEA under TC Project BUL/4/005 'Increasing Safety of Novi Han Repository', are presented in this paper. They comprise: assessment of radionuclide inventory and future waste arisings, characterisation of disposal vaults, characterisation of the site, safety assessment, upgrading of the monitoring system, option study for the selection of treatment and conditioning processes and the development of a conceptual design for low and intermediate level waste processing and storage facility, immediate measures for improvement of the existing disposal vaults and infrastructure, construction of above-ground temporary storage structures, and resuming the operation of the Novi Han Repository. The necessary activities for re-licensing of the Novi Han Repository, construction of a waste processing and storage facility and a disposal facility for spent sealed sources are discussed. (author)

  13. Recovery of Acetic Acid from An Ethanol Fermentation Broth by Liquid-Liquid Extraction (LLE) Using Various Solvents

    International Nuclear Information System (INIS)

    Pham, Thi Thu Huong; Kim, Tae Hyun; Um, Byung Hwan

    2015-01-01

    Liquid-liquid extraction (LLE) using various solvents was studied for recovery of acetic acid from a synthetic ethanol fermentation broth. The microbial fermentation of sugars presented in hydrolyzate gives rise to acetic acid as a byproduct. In order to obtain pure ethanol for use as a biofuel, fermentation broth should be subjected to acetic acid removal step and the recovered acetic acid can be put to industrial use. Herein, batch LLE experiments were carried out at 25°C using a synthetic fermentation broth comprising 20.0 g l -1 acetic acid and 5.0 g l -1 ethanol. Ethyl acetate (EtOAc), tri-n-octylphosphine oxide (TOPO), tri-n-octylamine (TOA), and tri-n-alkylphosphine oxide (TAPO) were utilized as solvents, and the extraction potential of each solvent was evaluated by varying the organic phase-to-aqueous phase ratios as 0.2, 0.5, 1.0, 2.0, and 4.0. The highest acetic acid extraction yield was achieved with TAPO; however, the lowest ethanol-to-acetic acid extraction ratio was obtained using TOPO. In a single-stage batch extraction, 97.0 % and 92.4 % of acetic acid could be extracted using TAPO and TOPO when the ratio of organic-to-aqueous phases is 4:1 respectively. A higher solvent-to-feed ratio resulted in an increase in the ethanol-to-acetic acid ratio, which decreased both acetic acid purity and acetic acid extraction yield.

  14. The acid-base buffer capacity of podzolic soils and its changes under the impact of treatment with the Mehra-Jackson and Tamm reagents

    Science.gov (United States)

    Maksimova, Yu. G.; Maryakhina, N. N.; Tolpeshta, I. I.; Sokolova, T. A.

    2010-10-01

    The acid-base buffer capacity before and after the treatment with the Mehra-Jackson and Tamm reagents was assessed by continuous potentiometric titration for the main genetic horizons of two profiles of podzolic soils in the Central Forest State Reserve. The total buffer capacity was calculated in the pH range from the initial titration point (ITP) to 3 for the acid titration and from the ITP to 10 for the base titration, as well as the buffer capacities in the pH intervals of 0.25. It was found that both treatments abruptly decreased the base buffer capacity, which reached 70-90% in the E horizons. The high direct linear correlation of the difference between the total base buffer capacities before and after each treatment with the content of Fe in the Tamm extract was revealed. From the results obtained, a conclusion was drawn that finely dispersed Fe hydroxides were the main solid-phase constituents ensuring the base buffer capacity, and the deprotonation of hydroxyl groups on the surface of Fe hydroxides was the essential buffer reaction during the base titration.

  15. Thermoluminescence authentication of T'ang and Han Dynasty pottery

    International Nuclear Information System (INIS)

    Price, D.M.

    1997-01-01

    More than 80 pieces of T'ang Dynasty and 40 Han Dynasty style ceramic wares have been analysed to determine the amount of thermoluminescence (TL) accumulated since the initial firing of the object and the level of the radiation flux which has created the TL. This paper presents a summary of the thermoluminescence analysis results. Approximately 60% of Han ceramics and 45% of the T'ang pottery authenticated have been shown to belong to periods other than that stylistically suggested. Items which have been found not to be of the anticipated antiquity generally fall into distinct age groups. Of the T'ang wares the most commonly copied item is found to be the horse and for the Han pieces, human figures and ewers/pots/vases represent the most frequently reproduced wares

  16. Operational safety analysis status of Novi Han repository

    International Nuclear Information System (INIS)

    Boiadjiev, A.

    2000-01-01

    This article presents the status of the safety studies and activities related to Novi Han repository. The case of this facility is such that no clear boundary exists between post-closure safety assessment and operational safety assessment. The major findings of these activities are given. The Safety Analysis Report (SAR) for Novi Han repository is developed by Risk Engineering Ltd. under a contract with the Committee on the Use of Atomic Energy for Peaceful Purposes. The general structure and main conclusions and recommendations of the SAR are presented. (author)

  17. Andragologie – idealistisch positivisme? De actualiteit van Hans Vaihinger

    Directory of Open Access Journals (Sweden)

    Ton Notten

    2015-12-01

    Full Text Available Hans Vaihinger. De filosofie van het alsof. Systeem van de theoretische, praktische en religieuze ficties van de mensheid op grond van een idealistisch positivisme. Met een aanhangsel over Kant en Nietzsche. Utrecht: IJzer, 2013, 464 p., € 49,90. ISBN 978 90 8684 106 4

  18. Steve Jobs, Ameerika Hans H. Luik / Kertu Ruus

    Index Scriptorium Estoniae

    Ruus, Kertu, 1977-

    2007-01-01

    Autor võrdleb Apple'i asutajat ja juhti Steve Jobsi Eesti meediaärimehe Hans H. Luigega. Vt. samas: Jobs: ärge raisake aega teiste elu elamisele; Forbes: iPhone'ist saab Apple'i suur hitt; CV: Steven Paul Jobs. Diagramm: Apple'i aktsia

  19. REVISITANDO A TEORIA PURA DO DIREITO DE HANS KELSEN

    OpenAIRE

    de Agostini, Kátia; Unibrasil

    2012-01-01

    O presente trabalho objetiva uma análise epistemológica da obra Teoria Pura do Direito, de Hans KELSEN. Aponta que o centro de interesse da Teoria Pura é a ciência jurídica, para qual KELSEN propõe um método de conhecimento pretensamente puro.

  20. Hans Christian Ørsted : natuurwetenschapper als estheticus

    NARCIS (Netherlands)

    Millekamp, Jan

    2012-01-01

    The Danish scientist Hans Christian Ørsted (1777-1851) is most famous for his discovery of electromagnetism, a discovery that literally and irreversibly changed our world. In Denmark he is also known as a poet and essayist. Interestingly, his scientific and his aesthetic work are closely

  1. [Hans Jakob Christoffel von Grimmelshausen. Saksa Simplicissimuse seiklused] / Meelis Friedenthal

    Index Scriptorium Estoniae

    Friedenthal, Meelis, 1973-

    2011-01-01

    Tutvustus: Grimmelshausen, Hans Jakob Christoffel von. Saksa Simplicissimuse seiklused, teisisõnu: ühe veidra vagabundi elulugu, kel Melchior Sternfels von Fuchshaim nimeks, et kus ja mis moel ta siia ilma sündis ning mida siin nägi, õppis, oma nahal tunda sai ja kannatas, nagu sellestki, miks ta siinsest ilmast vabatahtlikult loobub. [Tallinn] : Pegasus, c2010

  2. Homage to Professor Hans-Åke Gustafsson

    CERN Multimedia

    2010-01-01

    It was with deep sadness that we learned of the death of Professor Hans-Åke Gustafsson, an internationally recognized scientist, beloved colleague and friend. He passed away on Wednesday January 13th at the Lund University Hospital, surrounded by his loved ones, after a short battle against cancer. This is a great loss for all of us in ALICE and the whole heavy ion community. Hans-Åke, Professor at Lund University, was one of the pioneers of heavy ion physics with relativistic beams since its very beginning. He started his research at CERN, as a fellow at the ISOLDE ion beam facility, and immediately after, in the early 1980 joined the Plastic Ball collaboration at the Bevalac. One of the seminal papers of the field on the discovery of collective flow in relativistic nuclear collisions, co-authored by Hans-Åke, Hans Gutbrod and colleagues, stems from this period. From that point on he was always at the forefront of research with relativistic nuclear beams, being for three de...

  3. Book review : Street Architecture: Work by Hans van der Heijden

    NARCIS (Netherlands)

    Jenniskens, D.P.H.

    The recently published book Street Architecture is the result of a collaboration between Karin Templin, currently pursuing a PhD in architecture at the University of Cambridge, and Hans van der Heijden, an Amsterdam-based architect of mainly urban renewal projects and residential architecture. The

  4. ["Snow" and "Walpurgisnacht". Hans Castorp's exemplary maturation crises in "Zauberberg"].

    Science.gov (United States)

    Heinrich, K; Walter, C

    1995-01-01

    On the occasion of a rather incidental visit in the sanatorium "Berghof" at Davos, Hans Castorp, the--as to his primary personality--asthenic and low-profile protagonist of the "Zauberberg" is gradually getting caught up in the maelstrom of the there prevailing timelessness and irresponsibility, this being interrupted solely by two tapering to crisis episodes: his amouressness to Mme. Chauchat as an erotic crisis and by the visionary daydream during a snowstorm about the abilities of men as a cognitive, mental crisis. Both events are triggered by a pathoid irritability, following the maxim of Th. Mann that illness, decay and death as borderline experiences may be the presupposition for cognition and reversal. Both crises end without consequences--the "Zauberberg" is the negation of the novel of education and development in the narrower sense. The unsuccessfulness and undecidedness of Hans Castorp's existence culminate in the open end of the novel, regarding his surviving on the battle field, and is in strict contrast to Adrian Leverkühn's determined autoinfection with Lues with the aim of artistic perfection and the creative break-through of "Doctor Faustus". Hans Castorp's regression and self-fragmentation within the decadent-morbid atmosphere of the sanatorium lead to his storming into the battles of the First World War as a last and existential crisis; it is here where finally the individual and national fate are merging. Hans Castorp becomes the paradigma of the German pre-war bourgeoisie and its crisis-prone development.

  5. Hans Bethe, Powering the Stars, and Nuclear Physics

    Science.gov (United States)

    dropdown arrow Site Map A-Z Index Menu Synopsis Hans Bethe, Energy Production in Stars, and Nuclear Physics physics, built atomic weapons, and called for a halt to their proliferation. Bethe's dual legacy is one of Laboratory] from 1943 to 1946. Prior to joining the Manhattan Project, Bethe taught physics at Cornell

  6. EL PRINCIPIO DE RESPONSABILIDAD DE HANS JONAS O PRINCÍPIO DE RESPONSABILIDADE DE HANS JONAS HANS JONAS’ PRINCIPLE OF RESPONSIBILITY

    Directory of Open Access Journals (Sweden)

    José Eduardo de Siqueira

    2001-01-01

    Full Text Available Este trabajo es una reflexión sobre la principal obra del filósofo alemán contemporáneo, Hans Jonas. Muestra la trayectoria intelectual de Jonas hasta llegar al rescate de la ética de la responsabilidad, que Max Weber sugiere en obras de comienzos del siglo. El Principio de la Responsabilidad de Jonas es una evaluación sumamente crítica de la ciencia moderna y de su "brazo armado", la tecnología. El filósofo muestra la necesidad que el ser humano tiene de actuar con cautela y humildad frente al enorme poder transformador de la tecnocienciaEste trabalho é uma reflexão sobre a principal obra do filósofo alemão contemporâneo, Hans Jonas. Apresenta a trajetória intelectual de Jonas até o resgate da ética da responsabilidade que Max Weber sugere em obras do começo do século XX. O Princípio da Responsabilidade de Jonas é uma apreciação extremamente crítica da ciência moderna e de seu "braço armado", a tecnologia. O filósofo mostra que é necessário o ser humano agir com cautela e humildade ante o enorme poder transformador da tecnociênciaThis paper is a reflection on the main work of the german philosopher Hans Jonas. It shows his intellectual trajectory till the point of the rescueing of the ethics of responsibility, suggested in Max Weber ’s works of the beginning of this century. Jonas’ principle of responsibility is an extremely critical analysis of modern science and its principal "armed arm", technology. The philosopher expounds the need all human beings have to act with caution and humility in face of the tremendous transforming power technoscience posseses

  7. Inland Ertebølle Culture: the importance of aquatic resources and the freshwater reservoir effect in radiocarbon dates from pottery food crusts

    Directory of Open Access Journals (Sweden)

    Bente Philippsen

    2014-11-01

    Full Text Available The Ertebølle culture is a late Mesolithic hunter-gatherer-fisher culture in southern Scandinavia, northern Germany and Poland. Archaeological finds as well as scientific analyses of humans and their artefacts indicate the great importance of aquatic resources, both marine and freshwater, to Ertebølle subsistence. In northern Germany, modern freshwater fish samples can have very high apparent radiocarbon ages (up to 3000 years. If such dramatic 'freshwater reservoir effects' also existed during the late Mesolithic, they could lead to artificially old radiocarbon dates for the bones of Ertebølle humans and domestic dogs, and for carbonised food crusts on cooking pots. Conversely, if we can demonstrate radiocarbon age 'offsets' in such samples, we can often attribute them to the exploitation of freshwater food resources. This article discusses methods of identifying freshwater resources in prehistoric pottery, including radiocarbon reservoir effects. We consider the results of radiocarbon, stable isotope and elemental analyses of food crusts on prehistoric pottery from four sites in the Alster and Trave valleys: Kayhude, Schlamersdorf, Bebensee and Seedorf.

  8. Hans Christian Ørsted reading nature's mind

    CERN Document Server

    Christensen, Dan Charly

    2013-01-01

    Hans Christian Orsted (1777-1851) is of great importance as a scientist and philosopher far beyond the borders of Denmark and his own time. At the centre of an international network of scholars, he was instrumental in founding the world picture of modern physics. Orsted was the physicist who brought Kant's metaphysics to fruition. In 1820 his discovery of electro-magnetism, a phenomenon that could not possibly exist according to his adversaries, changed the course of research in physics. It inspired Michael Faraday's experiments and discovery of the adverse effect, magneto-electric induction. The two physical phenomena were later described in mathematical equations by J.C. Maxwell. Together these discoveries constitute the prerequisites for the overwhelming development of modern technology. But Orsted was also one of the cultural leaders and organizers of the Danish Golden Age (together with Grundtvig, Kierkegaard, and Hans-Christian Andersen, his protege), and made significant contributions to aesthetics, ph...

  9. Excited state nuclear forces from the Tamm-Dancoff approximation to time-dependent density functional theory within the plane wave basis set framework

    Science.gov (United States)

    Hutter, Jürg

    2003-03-01

    An efficient formulation of time-dependent linear response density functional theory for the use within the plane wave basis set framework is presented. The method avoids the transformation of the Kohn-Sham matrix into the canonical basis and references virtual orbitals only through a projection operator. Using a Lagrangian formulation nuclear derivatives of excited state energies within the Tamm-Dancoff approximation are derived. The algorithms were implemented into a pseudo potential/plane wave code and applied to the calculation of adiabatic excitation energies, optimized geometries and vibrational frequencies of three low lying states of formaldehyde. An overall good agreement with other time-dependent density functional calculations, multireference configuration interaction calculations and experimental data was found.

  10. Hans Blumenberg: Philosophy and Literature from 1952 to 1958

    Directory of Open Access Journals (Sweden)

    Alberto Fragio

    2015-02-01

    Full Text Available From 1952 to 1958 Hans Blumenberg [1920-1996] wrote five philosophical reviews on literature published in the German journal Hochland that have received very little attention by the scholars. This paper focus on Blumenberg’s early reviews devoted to Franz Kafka [1883-1924], Evelyn Waugh [1903-1966], Ernest Hemingway [1899-1961], Thomas S. Eliot [1888- 1965] and William Faulkner [1897-1962].

  11. Reconstruction and modernization of Novi Han radioactive waste repository

    International Nuclear Information System (INIS)

    Kolev, I.; Dralchev, D.; Spasov, P.; Jordanov, M.

    2000-01-01

    This report presents briefly the most important issues of the study performed by EQE - Bulgaria. The objectives of the study are the development of conceptual solutions for construction of the following facilities in the Novi Han radioactive waste repository: an operational storage for unconditioned high level spent sources; new temporary buildings over the existing radioactive waste storage facilities; a rain-water draining system ect. The study also includes the engineering solutions for conservation of the existing facilities, currently full with high level spent sources. A 'Program for reconstruction and modernization' has been created, including the analysis of some regulation aspects concerning this program implementation. In conclusions the engineering problems of Novi Han repository are clear and appropriate solutions are available. They can be implemented in both cases of 'small' or 'large' reconstruction. The reconstruction project anyway should start with the construction of a new site infrastructure. Reconstruction and modernization of Novi Han radioactive waste repository is the only way to improve the management and safety of radioactive waste from medicine, industry and scientific research in Bulgaria

  12. Deep whole-genome sequencing of 90 Han Chinese genomes.

    Science.gov (United States)

    Lan, Tianming; Lin, Haoxiang; Zhu, Wenjuan; Laurent, Tellier Christian Asker Melchior; Yang, Mengcheng; Liu, Xin; Wang, Jun; Wang, Jian; Yang, Huanming; Xu, Xun; Guo, Xiaosen

    2017-09-01

    Next-generation sequencing provides a high-resolution insight into human genetic information. However, the focus of previous studies has primarily been on low-coverage data due to the high cost of sequencing. Although the 1000 Genomes Project and the Haplotype Reference Consortium have both provided powerful reference panels for imputation, low-frequency and novel variants remain difficult to discover and call with accuracy on the basis of low-coverage data. Deep sequencing provides an optimal solution for the problem of these low-frequency and novel variants. Although whole-exome sequencing is also a viable choice for exome regions, it cannot account for noncoding regions, sometimes resulting in the absence of important, causal variants. For Han Chinese populations, the majority of variants have been discovered based upon low-coverage data from the 1000 Genomes Project. However, high-coverage, whole-genome sequencing data are limited for any population, and a large amount of low-frequency, population-specific variants remain uncharacterized. We have performed whole-genome sequencing at a high depth (∼×80) of 90 unrelated individuals of Chinese ancestry, collected from the 1000 Genomes Project samples, including 45 Northern Han Chinese and 45 Southern Han Chinese samples. Eighty-three of these 90 have been sequenced by the 1000 Genomes Project. We have identified 12 568 804 single nucleotide polymorphisms, 2 074 210 short InDels, and 26 142 structural variations from these 90 samples. Compared to the Han Chinese data from the 1000 Genomes Project, we have found 7 000 629 novel variants with low frequency (defined as minor allele frequency genome. Compared to the 1000 Genomes Project, these Han Chinese deep sequencing data enhance the characterization of a large number of low-frequency, novel variants. This will be a valuable resource for promoting Chinese genetics research and medical development. Additionally, it will provide a valuable supplement to the 1000

  13. Release of ammonia from HAN-type PHA

    International Nuclear Information System (INIS)

    Zamecnik, J.R.

    1992-01-01

    A preliminary design basis for ammonia scrubbers in the DWPF has been issued. This design basis is based on a theoretical model of ammonia evolution from the SRAT, SME and RCT. It is desirable to acquire actual process data on ammonia evolution prior to performing detailed design of scrubbers for DWPF. The evolution of ammonia from the SRAT and SME in the Integrated DWPF Melter System (IDMS) was investigated during the HM4 run. In this run, Precipitate Hydrolysis Aqueous (PHA), which was made in the Precipitate Hydrolysis Experimental Facility (PHEF) using the HAN (hydroxylamine nitrate) process was used, thus resulting in PHA with a high concentration of ammonium ion

  14. Reconstruction and modernization of Novi Han radioactive waste repository

    International Nuclear Information System (INIS)

    Kolev, I.

    2001-01-01

    The paper is an overview of the Feasibility Study for Reconstruction and Modernisation of Novi Han Radioactive Waste Repository (NHRWR), performed by EQE Bulgaria AD in 2000 for the Institute for Nuclear Research and Nuclear Energy of the Bulgarian Academy of Sciences. The Study develops a concept for overall reconstruction and modernisation of NHRWR, including rehabilitation and partial reconstruction of existing facilities and planning of new facilities for conditioning and storage of various radioactive wastes and spent sealed sources. The paper presents the general modernisation concept and outlines the proposed principle technical solutions for the existing and new facilities. (author)

  15. Hans Christian Andersen for Children, with Children, and by children

    DEFF Research Database (Denmark)

    Knudsen, Karin Esmann

    2018-01-01

    This special issue on children's literature and fairy tales has it focus on Hans Christian andersen: his unique way of telling and his influence on modern Danish children's literature, as well as the way his fairy tales are used pedagogically by teachers and by the children themselves in their play...... culture. thus the articles will show a range of different perspectives on andersen's fairy tales. the contemporary challenge of research in children's literature is to combine a literary perspective with other angles: children's literature as medie, as edagogical artefact, and as raw material for children...

  16. Hans Christian Ørsted, narratives, oeuvres and physics education

    DEFF Research Database (Denmark)

    Michelsen, Claus

    2017-01-01

    In 1820 the Danish scientist Hans Christian Ørsted discovered the relationship between electricity and magnetism by his famous wire-compass experiment. Ørsted was one of the foremost scientists of the nineteenth century, and he was also one of the leading figures in Denmark in the 19th century...... with culture, worldviews, and commerce, its philosophical assumptions, its epistemology and methodology. Narratives are introduced as a pedagogical support to this approach and two concrete examples of teaching sequences centred on the work and life of Ørsted is described in grade 7 and grade 9 classes...

  17. Hans Jonas: The Principle Responsability, Limits of Research (? and Nanotechnologies

    Directory of Open Access Journals (Sweden)

    Patricia Santos Martins

    2015-12-01

    Full Text Available The study intends to carry out the reading of the responsibility principle and the new ethical model narrated by Hans Jones to nanotechnology context. Study the historical context of political and economic development and the interrelations with technological development, visiting the transformation of homo sapiens - homo faber - homo tecnologicus. Check if operating at the nanoscale, comprised in the billionth of meter, has elements that may indicate possible damage that might compromise or offer risks to the exercise of rights for future generations. Therefore, we intend to find points of convergence between the management of the potential risks of nanotechnologies and the new ethical model proposed by Hans Jonas in his work "The principle responsibility test an ethics for technological civilization". The study sheds bases in the work cited as theoretical foundation for the study and is based on the notion of risk proposed by Niklas Luhmann, and uses the method of literature refers to these works as well as published articles involving the topics covered.

  18. Complete Blood Count Reference Intervals for Healthy Han Chinese Adults

    Science.gov (United States)

    Mu, Runqing; Guo, Wei; Qiao, Rui; Chen, Wenxiang; Jiang, Hong; Ma, Yueyun; Shang, Hong

    2015-01-01

    Background Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults. Methods A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi’an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples. Results Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles. Conclusion We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently. PMID:25769040

  19. Combining the Hanning windowed interpolated FFT in both directions

    Science.gov (United States)

    Chen, Kui Fu; Li, Yan Feng

    2008-06-01

    The interpolated fast Fourier transform (IFFT) has been proposed as a way to eliminate the picket fence effect (PFE) of the fast Fourier transform. The modulus based IFFT, cited in most relevant references, makes use of only the 1st and 2nd highest spectral lines. An approach using three principal spectral lines is proposed. This new approach combines both directions of the complex spectrum based IFFT with the Hanning window. The optimal weight to minimize the estimation variance is established on the first order Taylor series expansion of noise interference. A numerical simulation is carried out, and the results are compared with the Cramer-Rao bound. It is demonstrated that the proposed approach has a lower estimation variance than the two-spectral-line approach. The improvement depends on the extent of sampling deviating from the coherent condition, and the best is decreasing variance by 2/7. However, it is also shown that the estimation variance of the windowed IFFT with the Hanning is significantly higher than that of without windowing.

  20. Meeleparanduslik teater / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2006-01-01

    Autor tunneb muret ühe uue tendentsi pärast, mida kohtab nii teatri NO99 ja Von Krahli viimastes lavastustes ("Nafta" ja "Võluflööt") kui teisteski teatrites (Linnateatri "Genoom"). Seda tendentsi nimetab ta "meeleparanduslikuks teatriks" ja näeb selles mitmeid probleeme

  1. Raamatulett / Jaanus Tamm

    Index Scriptorium Estoniae

    Tamm, Jaanus

    1996-01-01

    Grazie, Marie Eugenie delle. Raamat armastusest; Macdonald, Finlay. Minu noorusmaa; Duckwell, Ernest Simon. Misery Halli saladus; Van Dine, S. S. Greene'i mõrvajuhtum; Van Dine, S. S. Kanaarilinnu mõrvajuhtum

  2. Sant / Jakob Tamm

    Index Scriptorium Estoniae

    Tamm, Jakob

    2003-01-01

    Sisu: Sant ; Kepitükk ; Kask ; Kõrts ; Sulase mõte ; Surm ; Ahervars ; Orjakivi ; Odavad orjad : [Eesti rahva muinasjutt] ; Kaks püssipauku : [keskaja muinasjutt] ; Ulli allik ; Ussipealik : [muinasjutt] ; Ussi hari ; Varjatud varandus ; Hundi loomine : [rahvajutt] ; Röövli heategu ; Õnn ; Orjavaim ; Ema-armastus ; Isa õpetus ; Moksi Jõõva ; Puugi kinnipanek ; Õnnevalamine ; Suits Ebavere mäel ; Eksituses ; Sikk ; Kodukäija ; Kurja küüsis ; Rongatsi Mats ; Kõrtsi ees ; Rehetuli : [rahvanali] ; Ilm on suur : [rahvanali] ; Lüpsik

  3. Raamatulett / Jaanus Tamm

    Index Scriptorium Estoniae

    Tamm, Jaanus

    1996-01-01

    Highsmith, Patricia. Ripley mäng ; Chichester, J. J. Vahialune vaikib ; Kuznetsova, Agnia. Dolly ; Kallas, Aino. Suurlinnade udus ja säras ; Kallas, Aino. Pööripäevad ; Singer, Isaac Bashevis. Saatan Gorais; Patukahetseja

  4. Muusika / Saari Tamm

    Index Scriptorium Estoniae

    Tamm, Saari, 1968-

    2005-01-01

    Lühisõnumid: ERSO osales Läänemere festivalil. 18. - 29. VIII toimuvad EMAs suvekursused "Crossing Borders in interpretation of Classical Music and jazz". Konstantin Türnpu 140. 22. - 24. VIII toimub XII Lõuna-Eesti noorte pianistide suvekool. 21. VIII esineb Estonia kontserdisaalis Helsinki Festival Orchestra. 20. VIII toimub Tartu laululaval Olav Ehala loomingu galakontsert

  5. Lugemisnoppeid: antropoloogia / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2012-01-01

    Tutvustus: Jürgenson, Aivar. Ladina rahva seas : Argentina ja sealsed eestlased. Tallinn, 2011 ; Annist, Aet. Otsides kogukonda sotsialismijärgses keskuskülas : arenguantropoloogiline uurimus. Tallinn : Tallinna Ülikooli Kirjastus, 2011. (Acta Universitatis Tallinnensis. Socialia) ; Hiiemäe, Reet. Kaitsemaagia eesti rahvausundis. Tallinn, 2012 ; Augé, Marc. Kohad ja mittekohad : sissejuhatus ülimodernsuse antropoloogiasse. Tallinn : Tallinna Ülikooli Kirjastus, 2012. (Bibliotheca controversiarum)

  6. The spatially resolved characterisation of Egyptian blue, Han blue and Han purple by photo-induced luminescence digital imaging.

    Science.gov (United States)

    Verri, G

    2009-06-01

    The photo-induced luminescence properties of Egyptian blue, Han blue and Han purple were investigated by means of near-infrared digital imaging. These pigments emit infrared radiation when excited in the visible range. The emission can be recorded by means of a modified commercial digital camera equipped with suitable glass filters. A variety of visible light sources were investigated to test their ability to excite luminescence in the pigments. Light-emitting diodes, which do not emit stray infrared radiation, proved an excellent source for the excitation of luminescence in all three compounds. In general, the use of visible radiation emitters with low emission in the infrared range allowed the presence of the pigments to be determined and their distribution to be spatially resolved. This qualitative imaging technique can be easily applied in situ for a rapid characterisation of materials. The results were compared to those for Egyptian green and for historical and modern blue pigments. Examples of the application of the technique on polychrome works of art are presented.

  7. Ultra-fast computation of electronic spectra for large systems by tight-binding based simplified Tamm-Dancoff approximation (sTDA-xTB)

    International Nuclear Information System (INIS)

    Grimme, Stefan; Bannwarth, Christoph

    2016-01-01

    The computational bottleneck of the extremely fast simplified Tamm-Dancoff approximated (sTDA) time-dependent density functional theory procedure [S. Grimme, J. Chem. Phys. 138, 244104 (2013)] for the computation of electronic spectra for large systems is the determination of the ground state Kohn-Sham orbitals and eigenvalues. This limits such treatments to single structures with a few hundred atoms and hence, e.g., sampling along molecular dynamics trajectories for flexible systems or the calculation of chromophore aggregates is often not possible. The aim of this work is to solve this problem by a specifically designed semi-empirical tight binding (TB) procedure similar to the well established self-consistent-charge density functional TB scheme. The new special purpose method provides orbitals and orbital energies of hybrid density functional character for a subsequent and basically unmodified sTDA procedure. Compared to many previous semi-empirical excited state methods, an advantage of the ansatz is that a general eigenvalue problem in a non-orthogonal, extended atomic orbital basis is solved and therefore correct occupied/virtual orbital energy splittings as well as Rydberg levels are obtained. A key idea for the success of the new model is that the determination of atomic charges (describing an effective electron-electron interaction) and the one-particle spectrum is decoupled and treated by two differently parametrized Hamiltonians/basis sets. The three-diagonalization-step composite procedure can routinely compute broad range electronic spectra (0-8 eV) within minutes of computation time for systems composed of 500-1000 atoms with an accuracy typical of standard time-dependent density functional theory (0.3-0.5 eV average error). An easily extendable parametrization based on coupled-cluster and density functional computed reference data for the elements H–Zn including transition metals is described. The accuracy of the method termed sTDA-xTB is first

  8. Ultra-fast computation of electronic spectra for large systems by tight-binding based simplified Tamm-Dancoff approximation (sTDA-xTB)

    Energy Technology Data Exchange (ETDEWEB)

    Grimme, Stefan, E-mail: grimme@thch.uni-bonn.de; Bannwarth, Christoph [Mulliken Center for Theoretical Chemistry, Institut für Physikalische und Theoretische Chemie, Rheinische Friedrich-Wilhelms Universität Bonn, Beringstraße 4, 53115 Bonn (Germany)

    2016-08-07

    The computational bottleneck of the extremely fast simplified Tamm-Dancoff approximated (sTDA) time-dependent density functional theory procedure [S. Grimme, J. Chem. Phys. 138, 244104 (2013)] for the computation of electronic spectra for large systems is the determination of the ground state Kohn-Sham orbitals and eigenvalues. This limits such treatments to single structures with a few hundred atoms and hence, e.g., sampling along molecular dynamics trajectories for flexible systems or the calculation of chromophore aggregates is often not possible. The aim of this work is to solve this problem by a specifically designed semi-empirical tight binding (TB) procedure similar to the well established self-consistent-charge density functional TB scheme. The new special purpose method provides orbitals and orbital energies of hybrid density functional character for a subsequent and basically unmodified sTDA procedure. Compared to many previous semi-empirical excited state methods, an advantage of the ansatz is that a general eigenvalue problem in a non-orthogonal, extended atomic orbital basis is solved and therefore correct occupied/virtual orbital energy splittings as well as Rydberg levels are obtained. A key idea for the success of the new model is that the determination of atomic charges (describing an effective electron-electron interaction) and the one-particle spectrum is decoupled and treated by two differently parametrized Hamiltonians/basis sets. The three-diagonalization-step composite procedure can routinely compute broad range electronic spectra (0-8 eV) within minutes of computation time for systems composed of 500-1000 atoms with an accuracy typical of standard time-dependent density functional theory (0.3-0.5 eV average error). An easily extendable parametrization based on coupled-cluster and density functional computed reference data for the elements H–Zn including transition metals is described. The accuracy of the method termed sTDA-xTB is first

  9. Hans H. Ussing - scientific work: contemporary significance and perspectives

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid

    2002-01-01

    As a zoologist, Hans H. Ussing began his scientific career by studying the marine plankton fauna in East Greenland. This brought him in contact with August Krogh at the time George de Hevesy, Niels Bohr and Krogh planned the application of artificial radioactive isotopes for studying the dynamic...... at the cellular level and raised new questions about cellular mechanisms of actions of hormones and drugs. His theoretical treatment of osmotic water fluxes versus fluxes of deuterium labeled water resulted in the discovery of epithelial water channels. His discovery of paracellular transport in frog skin bridged...... studies of high and low resistance epithelia and generalized the description of epithelial transport. He devoted the last decade of his scientific life to solute-coupled water transport. He introduced the sodium recirculation theory of isotonic transport, and in an experimental study, he obtained...

  10. Selected Works Of Hans A Bethe (With Commentary)

    International Nuclear Information System (INIS)

    Bethe, Hans A.

    1997-01-01

    Hans A Bethe received the Nobel Prize for Physics in 1967 for his work on the production of energy in stars. A living legend among the physics community, he helped to shape classical physics into quantum physics and increased the understanding of the atomic processes responsible for the properties of matter and of the forces governing the structures of atomic nuclei. This collection of papers by Prof Bethe dates from 1928, when he received his PhD, to now. It covers several areas and reflects the many contributions in research and discovery made by one of the most important and eminent physicists of all time. Special commentaries have been written by Prof Bethe to complement the selected papers

  11. [Hans Selye, the grandmaster of creativity and originality].

    Science.gov (United States)

    Somogyi, Árpád

    2015-08-30

    Hans Selye, the father of the stress concept, was a giant of science of the twentieth century. Beyond his best-known work on stress, he also made several discoveries on various other fields of experimental medicine. He described and characterized various pluricausal diseases. In addition, he made pivotal contributions to the broad field of endocrinology, especially to the classification of steroids and to our better understanding of their mode of action. He developed surgical technics and experimental animal models suitable for studying the pathogenesis and prevention of human diseases. Selye was an extremely well educated, highly intelligent and disciplined individual, an original and creative scientist, an outstanding teacher, a philosopher, a prolific author, a fabulous communicator and a gifted organizer successfully establishing, developing and managing a major academic research institution, the word-famous Institute of Experimental Medicine and Surgery of the University of Montreal.

  12. Micronuclei rate in workers of Novi Han radioactive waste repository

    International Nuclear Information System (INIS)

    Atamasova, P.; Hadjidekova, V.

    2003-01-01

    A cytogenetic study has been carried out by the micronucleus test of lymphocytes from the peripheral blood of 30 workers from the Novi Han radioactive waste repository. The results are compared to the results of a control group of 6 persons from the administrative staff, and to outside group of 39 healthy persons. All persons are questioned through a special questionnaire about their occupational, medical, and social status. The rate of the cells with micronuclei and the total number of the micronuclei are analysed in the peripheral blood lymphocytes using the cytogenesis-block micronucleus test. The comparison of the results does not show an increase of the lymphocytes with micronuclei in the workers

  13. Are the new resonances superexotic or collapsed han nambu states

    International Nuclear Information System (INIS)

    Lipkin, H.J.

    1975-01-01

    Possible descriptions of the psi states as unorthodox color octet states in the Han-Nambu model are discussed. Simple quark-antiquark configurations are unbound in the static colored gluon exchange model. More complicated states having indefinite numbers of quark-antiquark pairs, or ''collapsed configurations'' might be bound. Their radiative decays would be suppressed by the small overlap with conventional states. The unexplained spin dependence of both conventional and new meson spectra is pointed out. The rho-π mass difference is about half the rho-f splitting, while the B-f splitting is small. New particles have low-lying vectors and no trace of pseudo-scalars. A link between these spectra is suggested by the observation that precisely these features follow from adding a repulsive core to the colored gluon exchange potential in the color singlet spin triplet state which also reverses sign in the color octet states. (author)

  14. From chemistry to consciousness the legacy of Hans Primas

    CERN Document Server

    Müller-Herold, Ulrich

    2016-01-01

    This book reflects on the significant and highly original scientific contributions of Hans Primas. A professor of chemistry at ETH Zurich from 1962 to 1995, Primas continued his research activities until his death in 2014. Over these 50 years and more, he worked on the foundations of nuclear magnetic resonance spectroscopy, contributed to a number of significant issues in theoretical chemistry, helped to clarify central topics in quantum theory and the philosophy of physics, suggested innovative ways of addressing interlevel relations in the philosophy of science, and introduced cutting-edge approaches in the flourishing young field of scientific studies of consciousness. His work in these areas of research and its continuing impact is described by noted experts, colleagues, and collaborators of Primas. All authors contextualize their contributions to facilitate the mutual dialog between these fields.

  15. Responsibility to Nature? Hans Jonas and Environmental Ethics

    Directory of Open Access Journals (Sweden)

    Peter Wolsing

    2013-11-01

    Full Text Available This paper presents the philosopher Hans Jonas’s idea of an environmental ethics. Through an outline of the development of man’s relation to nature from Greek antiquity to the present it is argued that science and technology in modernity favour a relation of exploitation which is partly the cause of fatal climate changes. Through Jonas’s philosophical notion of an ontology of man as an alternative to classical dualism and by means of a turn to an ontological interpretation of Kant’s categorical imperative, it is argued that mankind has a responsibility to both coming generations and to the biosphere as a whole. Not only does this ontological shift from philosophy of mind to an ontology of man transcend dualism in philosophy, it throws a new critical light on the technological development and suggests a new way of considering man’s place in the cosmos.

  16. Religions without God? Hans Kelsen, Anthropologist of Modernity

    Directory of Open Access Journals (Sweden)

    Paolo Di Lucia

    2015-11-01

    Full Text Available In 2012 an unpublished book by the Austrian legal philosopher Hans Kelsen, Secular Religion, has been posthumously published. This book, written by Kelsen between 1952 and 1964 in the United States, severely criticizes those theories of politics and culture that misinterpret modern social philosophy, science and politics as new religions, mainly adopting the controversial concept of “secular religión.” In the first part of the paper, we reconstruct the genesis of the book and the complex events that led to its final version, and we underline the motives that led Kelsen to write this vehement polemic in defense of the spirit of modernity, and eventually to withdraw it. In the second part of the paper, we investigate some of the main methodological and theoretical contributions that this work, albeit its critical tenor, is able to give to an anthropology of modernity.

  17. Virginia gutierrez de pineda: ve lo que todos han visto pero piensa lo Que otros no han pensado

    Directory of Open Access Journals (Sweden)

    Ligia Echeverri Ángel

    1997-04-01

    Full Text Available Este ensayo pretende hilvanar las cualidades innatas con las condiciones ambientales y educativas que afianzaron y respaldaron el surgimiento de una personalidad científica de las ciencias sociales y humanas, en una época cuando las mujeres tenían bloqueado el acceso a la formación en este campo.Por cuestión de espacio, apenas sí se menciona lo más destacado de la creación científica y literaria de Virginia Gutiérrez de Pineda, privilegiando aquellas contribuciones que han producido mayor impacto en las comunidades académicas nacional e internacional.

  18. Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.

    Directory of Open Access Journals (Sweden)

    Lijie Ma

    Full Text Available Hereditary mutations in Tamm-Horsfall protein (THP/uromodulin gene cause autosomal dominant kidney diseases characterized by juvenile-onset hyperuricemia, gout and progressive kidney failure, although the disease pathogenesis remains unclear. Here we show that targeted expression in transgenic mice of a mutation within the domain of 8 cysteines of THP in kidneys' thick ascending limb (TAL caused unfolded protein response in younger (1-month old mice and apoptosis in older (12-month old mice. While the young mice had urine concentration defects and polyuria, such defects progressively reversed in the older mice to marked oliguria, highly concentrated urine, fibrotic kidneys and reduced creatinine clearance. Both the young and the old transgenic mice had significantly higher serum uric acid and its catabolic product, allantoin, than age-matched wild-type mice. This THP mutation apparently caused primary defects in TAL by compromising the luminal translocation and reabsorptive functions of NKCC2 and ROMK and secondary responses in proximal tubules by upregulating NHE3 and URAT1. Our results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses. Transgenic mice recapitulating human THP/uromodulin-associated kidney diseases could be used to elucidate their pathogenesis and test novel therapeutic strategies.

  19. Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia

    Science.gov (United States)

    Landry, Nichole K.; El-Achkar, Tarek M.; Lieske, John C.

    2017-01-01

    Hereditary mutations in Tamm-Horsfall protein (THP/uromodulin) gene cause autosomal dominant kidney diseases characterized by juvenile-onset hyperuricemia, gout and progressive kidney failure, although the disease pathogenesis remains unclear. Here we show that targeted expression in transgenic mice of a mutation within the domain of 8 cysteines of THP in kidneys’ thick ascending limb (TAL) caused unfolded protein response in younger (1-month old) mice and apoptosis in older (12-month old) mice. While the young mice had urine concentration defects and polyuria, such defects progressively reversed in the older mice to marked oliguria, highly concentrated urine, fibrotic kidneys and reduced creatinine clearance. Both the young and the old transgenic mice had significantly higher serum uric acid and its catabolic product, allantoin, than age-matched wild-type mice. This THP mutation apparently caused primary defects in TAL by compromising the luminal translocation and reabsorptive functions of NKCC2 and ROMK and secondary responses in proximal tubules by upregulating NHE3 and URAT1. Our results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses. Transgenic mice recapitulating human THP/uromodulin-associated kidney diseases could be used to elucidate their pathogenesis and test novel therapeutic strategies. PMID:29145399

  20. Theory of tamm surface states on the boundary between Hgsub(1-x)Cdsub(x)Te type semimetal and narrow-gap semiconductor

    International Nuclear Information System (INIS)

    Mekhtiyev, M.A.; Kalina, V.A.

    1980-01-01

    The conditions of appearance of tamm surface states and their energy spectrum on the boundary of semimetals and narrow-gap semiconductors are considered. By the Green function method the equation for surface state energy is obtained. The solution of the latter is analyzed in particular cases when energy of heavy hole zones of the semimetal and semiconductor is the same and when the heavy hole gap of the semiconductor is shifted down relatively to the semimetal of the same name gap as well as accurate computer calculation. It is shown that neither in parabolic limits, nor in cases of a strongly unparabolic semiconductor (semimetal) and a parabolic semimetal (semiconductor) the equation obtained has no solutions at small quasipulse values i.e. there are no surface states. In the case when the heavy hole zone of a semiconductor is shifted down for the value of the order of narrow-gap semiconductor the effective mass of surface states turns to be twice heavier than that of the semimetal volumetrical electrons [ru

  1. Tamm-Horsfall Glycoprotein Enhances PMN Phagocytosis by Binding to Cell Surface-Expressed Lactoferrin and Cathepsin G That Activates MAP Kinase Pathway

    Directory of Open Access Journals (Sweden)

    Chia-Li Yu

    2011-03-01

    Full Text Available The molecular basis of polymorphonuclear neutrophil (PMN phagocytosis-enhancing activity (PEA by human purified urinary Tamm-Horsfall glyco- protein (THP has not been elucidated. In this study, we found human THP bound to lactoferrin (LF and cathepsin G (CG expressed on the surface of PMN, identified by a proteomic study with MALDI-TOF- LC/LC/mass spectrometric analysis. Pre-incubation of 10% SDS-PAGE electrophoresed PMN lysates with monoclonal anti-LF or anti-CG antibody reduced the binding with THP. To elucidate the signaling pathway of THP on PMN activation, we found THP enhanced ERK1/2 phosphorylation, reduced p38 MAP kinase phosphorylation, but had no effect on DNA binding of the five NF-kB family members in PMN. To further clarify whether the carbohydrate-side chains or protein-core structure in THP molecule is responsible for THP-PEA, THP was cleaved by different degrading enzymes with carbohydrate specificity (neuraminidase and β-galactosidase, protein specificity (V8 protease and proteinase K or glycoconjugate specificity (carboxylpeptidase Y and O-sialoglycoprotein endopeptidase. We clearly demonstrated that the intact protein-core structure in THP molecule was more important for THP-PEA than carbohydrate-side chains. Putting these results together, we conclude that THP adheres to surface-expressed LF and CG on PMN and transduces signaling via the MAP kinase pathway to enhance PMN phagocytosis.

  2. Esmamuljed maaülikoolist / Kristi Kägu, Ülle Ütsik, Priit Veeroja, Simon Soll...[jt.] ; küsitlenud Sirje Pärismaa

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele, kuidas on möödunud esimesed nädalad, vastasid Maaülikooli esmakursuslased: majandusarvestuse ja finantsjuhtimise erialalt Kristi Kägu, ökonoomika ja ettevõtluse erialalt Ülle Ütsik, veemajanduse erialalt Priit Veeroja, maastikuarhitektuuri erialalt Simon Soll, kinnisvara planeerimise erialalt Merlin Henning ja liha- ja piimatehnoloogia erialalt Liina Politanova

  3. Hans Christian Ørsted, narratives, oeuvres and physics education

    Science.gov (United States)

    Michelsen, Claus

    2017-05-01

    In 1820 the Danish scientist Hans Christian Ørsted discovered the relationship between electricity and magnetism by his famous wire-compass experiment. Ørsted was one of the foremost scientists of the nineteenth century, and he was also one of the leading figures in Denmark in the 19th century with a vital influence in the fields of aesthetics, philosophy, education, politics and religion. In this paper the work and life of Ørsted is placed in a school context with the rationale to accentuate that learning of physics needs to be accompanied by learning about physics, its history, its interrelations with culture, worldviews, and commerce, its philosophical assumptions, its epistemology and methodology. Narratives are introduced as a pedagogical support to this approach and two concrete examples of teaching sequences centred on the work and life of Ørsted is described in grade 7 and grade 9 classes, respectively. A prominent feature of the sequences was that all the activities of the pupils as an outcome should have a product. Products like a movie, a loudspeaker, a fairy tale or a newspaper played an important role by encouraging the pupils to produce both personally meaningful works as well as products that are useful for their community.

  4. Hans Küpper discusses science and venture capital.

    Science.gov (United States)

    Küpper, Hans

    2004-11-01

    Hans Küpper has over 30 years of experience in the biotechnology industry in areas from research to R&D management, technology assessment and business acquisitions. He received his PhD in 1974 from the University of Heidelberg. After additional academic research at the Massachusetts Institute of Technology in the USA and at the University of Heidelberg, Germany, he joined Biogen in 1980. Here, he held various R&D positions, the last of which was Assistant Research Director. In 1985, he joined Behringwerke AG, Marburg, to build up and head the company's Molecular Biology Department and thereafter became Head of R&D of the Immunology/Oncology Business Unit. In 1999 he joined Global Life Science Ventures at their Munich office. Dr Küpper is the author of numerous publications and patents/applications and has also served as a consultant to the Pharmaceutical Industry and the European Commission. He is a board member of several early stage companies in the life sciences.

  5. Hans Loewald, psychoanalysis, and the project of autonomy.

    Science.gov (United States)

    Whitebook, Joel

    2008-12-01

    For some time psychoanalysts have tended to view Freud's cultural writings--concerning modernity, secularism, science, and religion--disparagingly, seeing them as the unscientific speculations of a misguided genius. But the questions Freud explored in those works are pressing topics that deserve serious attention. Just as fascism provided the historical context in which the critical theorists of the Frankfurt School developed a psychoanalytic social theory in the 1930s and 1940s, so the rise of fundamentalism demands a similar effort today. The "project of autonomy" conceptualized by the psychoanalyst-philosopher Castoriadis can be used to situate psychoanalysis in its broader historical context, as part of the emancipatory movement of modernity, and to elucidate fundamentalism as an attempt to turn back that project and reinstate the values of premodern traditional societies. Because the widespread aversion to secularism today is in no small degree the responsibility of secularists themselves--Freud's relatively crude and simplistic disregard of some of the deepest yearnings of humankind is a case in point--it is time to formulate, using the work of Hans Loewald, a more sensitive and sophisticated psychoanalytic view of religion. Yet psychoanalytic secularists must avoid overcompensating for past mistakes by giving too much ground to antisecularists. The legitimate desire to do justice to religion must not trump the need to advance the project of autonomy as a first priority.

  6. La agonía del Eros, Han (2014.

    Directory of Open Access Journals (Sweden)

    Laura Díaz Traversa

    2016-11-01

    Full Text Available Byung-Chul Han, Dr. en Filosofía de origen coreano, realizó sus estudios en Alemania, donde reside actualmente y se desempeña como docente de Filosofía y Estudios Culturales en la Universidad de las Artes de Berlín. Desde el punto de vista teórico-académico se inscribe en el Pensamiento Crítico de la escuela de Frankfurt, siendo alumno privilegiado de Honneth. Es considerado una de las voces filosóficas más prestigiosas de dicho país, y sus obras se caracterizan por ser breves, de fácil lectura, sorprendiendo al público por su fuerza y pertinencia en la actualidad. La agonía del Eros es la tercera obra del autor traducida al castellano y promete seguir el mismo camino que las anteriores, es decir, convertirse en una obra fundamental del Pensamiento Crítico.

  7. Nuclear forces the making of the physicist Hans Bethe

    CERN Document Server

    Schweber, Silvan S

    2012-01-01

    On the fiftieth anniversary of Hiroshima, Nobel-winning physicist Hans Bethe called on his fellow scientists to stop working on weapons of mass destruction. What drove Bethe, the head of Theoretical Physics at Los Alamos during the Manhattan Project, to renounce the weaponry he had once worked so tirelessly to create? That is one of the questions answered by "Nuclear Forces", a riveting biography of Bethe's early life and development as both a scientist and a man of principle. As Silvan Schweber follows Bethe from his childhood in Germany, to laboratories in Italy and England, and on to Cornell University, he shows how these differing environments were reflected in the kind of physics Bethe produced. Many of the young quantum physicists in the 1930s, including Bethe, had Jewish roots, and Schweber considers how Liberal Judaism in Germany helps explain their remarkable contributions. A portrait emerges of a man whose strategy for staying on top of a deeply hierarchical field was to tackle only those problems h...

  8. Leprosy type 1 reactions and erythema nodosum leprosum Reações hansênicas do tipo 1 e eritema nodoso hansênico

    Directory of Open Access Journals (Sweden)

    Indira P. Kahawita

    2008-02-01

    Full Text Available Leprosy reactions are a major cause of nerve damage and morbidity in a significant proportion of leprosy patients. Reactions are immunologically mediated and can occur even after successful completion of multi-drug therapy. This review focuses on the epidemiology, pathology and treatment of leprosy type 1 reactions, erythema nodosum leprosum and silent neuropathy.As reações hansênicas são a principal causa de dano e morbidade neural em grande parte dos pacientes hansênicos. São imunomediadas e podem ocorrer mesmo após o término bem sucedido da poliquimioterapia. Esta revisão enfoca a epidemiologia, a patologia e o tratamento das reações hansênicas do tipo 1, do eritema nodoso hansênico e da neuropatia silenciosa.

  9. Jean-François Gallotte, Joëlle Malberg, Carbone 14 le film, Les Mutins de Pangée

    OpenAIRE

    Curien, Julie

    2014-01-01

    Carbone 14 le film est un témoignage sur le mouvement des radios libres, à travers l'exemple de « Carbone 14 », « la radio active » devenue « la radio qui vous encule par les oreilles ». Filmé en 4 jours à la rentrée 1982, avec du matériel volé, le film ovni de Jean-François Galotte et Joëlle Malberg est sélectionné au Festival de Cannes en 1983. Il fait un tollé qui retombe comme une crêpe, aux oubliettes : on n'en parle plus avant... 2011, trente ans après la création de la radio culte et c...

  10. Pitkälle kehitetyssä terapiassa käytettävien lääkkeiden erityinen myyntilupamenettely

    OpenAIRE

    Aarnio, Hanna

    2013-01-01

    Tutkielmassa tarkastellaan pitkälle kehitetyssä terapiassa käytettävien lääkkeiden, eli ATMP-lääkkeiden, keskitettyä myyntilupamenettelyä, joka on luotu Euroopan Parlamentin ja Neuvoston asetuksella EY 1394/2007. ATMP-lääkkeet sisältävät eloperäisiä raaka-aineita ja ovat siten bio-oikeudellisia sääntelykohteita. Tutkielman yhtenä tavoitteena on selvittää, mitä vaatimuksia bio-oikeudellinen näkökulma asettaa ATMP-lääkkeiden sääntelylle. Tutkielman toinen tavoite on selvittää, onko ATMP-lääkkei...

  11. Hans Jonas' thought on the ethics of research on human subjects ...

    African Journals Online (AJOL)

    Hans Jonas' thought on the ethics of research on human subjects and its implications for contemporary medical research in Nigeria was examined. The thinking and teachings of Hans Jonas was on the need for medical research to advance beyond the use animals for research and experimentations to research on human ...

  12. Varieties of European Economic Law and Regulation : Liber Amicorum for Hans Micklitz

    NARCIS (Netherlands)

    Purnhagen, K.; Rott, P.

    2014-01-01

    This is the first book to comprehensively analyze the work of Hans Micklitz, one of the leading scholars in the field of EU economic law. It brings together analysts, academic friends and critics of Hans Micklitz and results in a unique collection of essays that evaluate his work on European

  13. Linear-scaling time-dependent density-functional theory beyond the Tamm-Dancoff approximation: Obtaining efficiency and accuracy with in situ optimised local orbitals

    Energy Technology Data Exchange (ETDEWEB)

    Zuehlsdorff, T. J., E-mail: tjz21@cam.ac.uk; Payne, M. C. [Cavendish Laboratory, J. J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Hine, N. D. M. [Department of Physics, University of Warwick, Coventry CV4 7AL (United Kingdom); Haynes, P. D. [Department of Materials, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom); Department of Physics, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom); Thomas Young Centre for Theory and Simulation of Materials, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom)

    2015-11-28

    We present a solution of the full time-dependent density-functional theory (TDDFT) eigenvalue equation in the linear response formalism exhibiting a linear-scaling computational complexity with system size, without relying on the simplifying Tamm-Dancoff approximation (TDA). The implementation relies on representing the occupied and unoccupied subspaces with two different sets of in situ optimised localised functions, yielding a very compact and efficient representation of the transition density matrix of the excitation with the accuracy associated with a systematic basis set. The TDDFT eigenvalue equation is solved using a preconditioned conjugate gradient algorithm that is very memory-efficient. The algorithm is validated on a small test molecule and a good agreement with results obtained from standard quantum chemistry packages is found, with the preconditioner yielding a significant improvement in convergence rates. The method developed in this work is then used to reproduce experimental results of the absorption spectrum of bacteriochlorophyll in an organic solvent, where it is demonstrated that the TDA fails to reproduce the main features of the low energy spectrum, while the full TDDFT equation yields results in good qualitative agreement with experimental data. Furthermore, the need for explicitly including parts of the solvent into the TDDFT calculations is highlighted, making the treatment of large system sizes necessary that are well within reach of the capabilities of the algorithm introduced here. Finally, the linear-scaling properties of the algorithm are demonstrated by computing the lowest excitation energy of bacteriochlorophyll in solution. The largest systems considered in this work are of the same order of magnitude as a variety of widely studied pigment-protein complexes, opening up the possibility of studying their properties without having to resort to any semiclassical approximations to parts of the protein environment.

  14. Pagari 1 kortermaja = Apartment building at Pagari 1 / Reio Raudsepp ; kommenteerinud Reet Roos

    Index Scriptorium Estoniae

    Raudsepp, Reio

    2015-01-01

    Pagari 1 kortermaja (Tallinn, vanalinn) renoveerimisest. Hoone arhitekt Hans Schmidt, valmimisaasta 1911. Renoveerimise autorid Reio Raudsepp, Rasmus Tamme, Jaanus Saarepera; projekteerija ARS Projekt

  15. Comparison of maternal and newborn outcomes of Tibetan and Han Chinese delivering in Lhasa, Tibet

    Science.gov (United States)

    Miller, Suellen; Tudor, Carrie; Thorsten, Vanessa; Nyima; Sonam; Droyoung; Wright, Linda; Varner, Michael

    2009-01-01

    Aim To compare maternal and neonatal outcomes of Tibetan and Han Chinese women delivering vaginally at high altitude (3650 meters) in Lhasa, Tibet Autonomous Region, People’s Republic of China. Method Comparative analysis of data from a prospective observational study of Tibetan (n = 938) and Han Chinese (n = 146) women delivering at three hospitals between January 2004 and May 2005. Results Han Chinese women had higher rates of pre-eclampsia/gestational hypertension than Tibetan women, (10.3% vs 5.9%, P = 0.04). There was no difference in rates of postpartum hemorrhage between Tibetan and Han women (12.8% vs 17.1%, P = 0.15). Han newborns weighed significantly less than Tibetan newborns (P < 0.01), and were twice as likely to be small for gestational age, (24.5% vs 11.6%, P < 0.01). Tibetan newborns were less likely to have poor neonatal outcomes than Han newborns (P < 0.01). Conclusion In high altitude deliveries in Tibet, adverse outcomes were significantly more common among Han Chinese. PMID:19012697

  16. Leprosy type 1 reactions and erythema nodosum leprosum Reações hansênicas do tipo 1 e eritema nodoso hansênico

    OpenAIRE

    Indira P. Kahawita; Stephen L. Walker; Diana N.J. Lockwood

    2008-01-01

    Leprosy reactions are a major cause of nerve damage and morbidity in a significant proportion of leprosy patients. Reactions are immunologically mediated and can occur even after successful completion of multi-drug therapy. This review focuses on the epidemiology, pathology and treatment of leprosy type 1 reactions, erythema nodosum leprosum and silent neuropathy.As reações hansênicas são a principal causa de dano e morbidade neural em grande parte dos pacientes hansênicos. São imunomediadas ...

  17. Kauha : [luuletused] / Pjotr Zahharov ; udmurdi keelest tõlkinud soome keelde Viktor Shibanov, Hannu Oittinen, võru keelde tõlkinud Irina Orehhova, Kauksi Ülle, eesti keelde tõlkinud Taive Särg

    Index Scriptorium Estoniae

    Zahharov, Pjotr

    2005-01-01

    Sisu: Kauha / udmurdi keelest tõlkinud soome keelde Viktor Shibanov, Hannu Oittinen ; Kopsik / udmurdi keelest tõlkinud võru keelde Irina Orehhova, Kauksi Ülle ; Pu-pu : seitse pühendust rähnile 1, 3, 4, 4, 5-7 / udmurdi keelest tõlkinud eesti keelde Irina Orehhova, Taive Särg ; Metamorfoosid 3-8 / udmurdi keelest tõlkinud eesti keelde Irina Orehhova, Taive Särg

  18. Role of electrodes in ambient electrolytic decomposition of hydroxylammonium nitrate (HAN solutions

    Directory of Open Access Journals (Sweden)

    Kai Seng Koh

    2013-09-01

    Full Text Available Decomposition of hydroxylammonium nitrate (HAN solution with electrolytic decomposition method has attracted much attention in recent years due to its efficiencies and practicability. However, the phenomenon has not been well-studied till now. By utilizing mathematical model currently available, the effect of water content and power used for decomposition was studied. Experiment data shows that sacrificial material such as copper or aluminum outperforms inert electrodes in the decomposition of HAN solution. In the case of using copper wire to electrolyse HAN solutions, approximately 10 seconds is required to reach 100 °C regardless of concentration of HAN. In term of power consumption, 100 W–300 W was found to be the range in which decomposition could be triggered effectively using copper wire as electrodes.

  19. Genetic polymorphisms of 17 Y-chromosomal STRs in the Chengdu Han population of China.

    Science.gov (United States)

    Wang, Hui; Mao, Jiong; Xia, Yu; Bai, Xiaogang; Zhu, Wenqing; Peng, Duo; Liang, Weibo

    2017-07-01

    Chengdu is located at the center of Sichuan Province in southwestern China, and its primary demographic group is the Han population. The aim of this study was to contribute data detailing 17 Y-short tandem repeat (Y-STR) loci from 3291 Chengdu Han male samples analyzed with the AmpFLSTR ® Yfiler ® PCR Amplification Kit. We observed 2228 different haplotypes, and haplotype diversity (HD) was 0.9992. Gene diversity (GD) values for the 17 Y-STR loci of the Chengdu Han population ranged from 0.4156 to 0.9529. Haplotype match probability (HMC) was 0.0011. Compared with 13 reference populations of six provinces surrounding Chengdu, we observed that the Chengdu Han population was significantly different from each of these populations.

  20. Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population.

    Science.gov (United States)

    Hu, Guo-Xin; Dai, Da-Peng; Wang, Hao; Huang, Xiang-Xin; Zhou, Xiao-Yang; Cai, Jie; Chen, Hao; Cai, Jian-Ping

    2017-03-01

    To systematically investigate the genetic polymorphisms of the CYP3A4 gene in a Han Chinese population. The promoter and exons of CYP3A4 gene in 1114 unrelated, healthy Han Chinese subjects were amplified and genotyped by direct sequencing. In total, five previously reported alleles (*1G, *4, *5, *18B and *23) were detected, of which one allele (*23) was reported for the first time in Han Chinese population. Additionally, seven novel exonic variants were also identified and designated as new alleles CYP3A4*28-*34. This study provides the most comprehensive data of CYP3A4 polymorphisms in Han Chinese population and detects the largest number of novel CYP3A4 alleles in one ethnic group.

  1. The changes of plasma adrenomedullin level in Han and tibetan health adult men in plateau area

    International Nuclear Information System (INIS)

    Chen Shaolin

    2011-01-01

    To investigate the changes and clinical significance of plasma adrenomedullin in Han and Tibetan health adult men at the state of chronic hypoxia. The Han health adult who migrated and lived above sea level 4200 meter for 1∼3 years and the native Tibetan were involved in this study. The plasma adrenomedullin levels in both Han and Tibetan health adult men were measured by RIA. The results showed that the plasma adrenomedullin levels of native Tibetan were significantly higher than that of migrated Han worker (P<0.05). The plasma adrenomedullin might play a regulatory role on the physiological function in the health adult men who live in high altitude hypoxic state. (authors)

  2. A New Drawing of The Raising of Lazarus by Hans von Aachen

    Czech Academy of Sciences Publication Activity Database

    Fučíková, E.; Konečný, Lubomír

    -, č. 16 (2016), s. 89-94 ISSN 1213-5372 Institutional support: RVO:68378033 Keywords : Hans von Aachen * Raising of Lazarus * Caravaggio * Taddeo Zuccari Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Arts, Art history

  3. The Hans Gross Museum of Criminology at the Karl-Franzens-University Graz

    OpenAIRE

    Christian, Bachhiesl

    2008-01-01

    The Hans Gross Museum of Criminology combines scientific research and academic activity with a wide range of public events, such as crime thriller readings and stage plays, connecting the campus with the wider community.

  4. The inherent purpose of ontology in ecology: The immutable use of Hans Jonas’s works

    Directory of Open Access Journals (Sweden)

    Raluca Deleanu

    2014-12-01

    Full Text Available Theresa Morris, Hans Jonas’s Ethic of Responsibility: From Ontology to Ecology, Albany, NY: State University of New York Press, SUNY Series in Environmental Philosophy and Ethics, 2013, 236 p.

  5. Hans Vredeman de Vries in den böhmischen Bibliotheken

    Czech Academy of Sciences Publication Activity Database

    Muchka, Ivan

    č. 3 (2003), s. 29-40 ISSN 1213-5372 R&D Projects: GA AV ČR KSK9056118 Keywords : Renaissance * Hans Vredeman de Vries * Czech historical libraries Subject RIV: AL - Art, Architecture, Cultural Heritage

  6. Rootsi ja Eesti - kümme aastat koostööd / Hans Lepp

    Index Scriptorium Estoniae

    Lepp, Hans, 1950-

    2003-01-01

    Rootsi Instituudi kultuuri- ja ühiskonnaosakonna direktor Hans Lepp meenutab oma tegevust Rootsi kultuuriatašeena Eestis 1990ndatel aastatel. Ka autori meenutused kohtumisest RRi peadirektori Ivi Eenmaaga, ka rootsi saali asutamisest RRis

  7. Minu moto : alati kõrgustesse! Dr. Hans O. A. Koehn, ADDINOL Lube Oil GmbH osanik - 80 / Hans O. A. Koehn ; interv. Mikk Mehide

    Index Scriptorium Estoniae

    Koehn, Hans O. A.

    2006-01-01

    Maailma tippkvaliteediga määrdeaineid tootva Saksa õlifirma Addinol osanik dr. Hans O. A. Koehn on üks juhtivaid isikuid Saksamaa mineraalõli majanduses, tööst õlifirmas Valvoline, edasisest karjäärist ning Addinoli osanikuks saamisest

  8. Tallinna linnaelu kajastumine raehärra Hans Rotgersi märkmetes / Tiina Kala

    Index Scriptorium Estoniae

    Kala, Tiina, 1967-

    2008-01-01

    Hans Rotgersi aktiivne tegutsemisperiood hõlmab 15. sajandi viimase ja 16. saj. esimese veerandi. Kõige ulatuslikuma kirjaliku pärandi on ta endast maha jätnud Niguliste kiriku eestseisjana. Niguliste kiriku olulistest daatumitest. Maksujõuliste tallinlaste surma kajastumisest Rotgersi ülestähendustes. Rotgersi käsikirjas säilinud astroloogiliste ja meditsiiniliste soovituste kogust. Hans Rotgersi testamendist.

  9. Quantitative Analysis and Comparison of BMI among Han, Tibetan, and Uygur University Students in Northwest China

    OpenAIRE

    Jingya, Bai; Ye, He; Jing, Wang; Xi, Huanjiu; Tao, Hai

    2013-01-01

    Objectives. To fully analyze and compare BMI among Han, Tibetan, and Uygur university students, to discuss the differences in their physical properties and physical health, and thus to provide some theoretical suggestions for the improvement of students’ physical health. Methods. The cross-sectional random cluster sampling was used to investigate 10103 Han, Tibetan, and Uygur university students, aged 20–24 in Northwest China, and their height and weight were measured to calculate BMI. The BM...

  10. Population genetic data of the NGM SElect STR loci in Chinese Han population from Zhejiang region, China.

    Science.gov (United States)

    Zhou, Anju; Wu, Weiwei; Liu, Qiuling; Wu, Yeda; Lu, Dejian

    2013-03-01

    Genetic variations of the 17 NGM SElect STR loci in Chinese Han samples from the Zhejiang region were analyzed. The results show that the NGM SElect is a highly genetic informative system in Zhejiang Han, and this population shows quite different genetic data from other major populations in the world with the exception of the Fujian Han.

  11. Quantitative Analysis and Comparison of BMI among Han, Tibetan, and Uygur University Students in Northwest China

    Directory of Open Access Journals (Sweden)

    Bai Jingya

    2013-01-01

    Full Text Available Objectives. To fully analyze and compare BMI among Han, Tibetan, and Uygur university students, to discuss the differences in their physical properties and physical health, and thus to provide some theoretical suggestions for the improvement of students’ physical health. Methods. The cross-sectional random cluster sampling was used to investigate 10103 Han, Tibetan, and Uygur university students, aged 20–24 in Northwest China, and their height and weight were measured to calculate BMI. The BMI classification criteria for Chinese established by Work Group on Obesity in China (WGOC were used for screening. Results. Han, Tibetan, and Uygur university students show low obesity rates but high overweight rates. Han, Tibetan, and Uygur university students present a high rate of underweight, normal weight, and overweight, respectively. Female Han students show higher underweight and normal weight rates, but lower overweight and obesity rates, than male Han students. Female Tibetan students show higher normal weight rate, but lower overweight and obesity rates, than male Tibetan students. BMI increases with age for male students but decreases with age for female students. Male Uygur students show higher obesity rate than female Uygur students. Tibetan and Uygur university students have higher BMI than other minorities in South China.

  12. Quantitative Analysis and Comparison of BMI among Han, Tibetan, and Uygur University Students in Northwest China

    Science.gov (United States)

    Jingya, Bai; Ye, He; Jing, Wang; Xi, Huanjiu; Tao, Hai

    2013-01-01

    Objectives. To fully analyze and compare BMI among Han, Tibetan, and Uygur university students, to discuss the differences in their physical properties and physical health, and thus to provide some theoretical suggestions for the improvement of students' physical health. Methods. The cross-sectional random cluster sampling was used to investigate 10103 Han, Tibetan, and Uygur university students, aged 20–24 in Northwest China, and their height and weight were measured to calculate BMI. The BMI classification criteria for Chinese established by Work Group on Obesity in China (WGOC) were used for screening. Results. Han, Tibetan, and Uygur university students show low obesity rates but high overweight rates. Han, Tibetan, and Uygur university students present a high rate of underweight, normal weight, and overweight, respectively. Female Han students show higher underweight and normal weight rates, but lower overweight and obesity rates, than male Han students. Female Tibetan students show higher normal weight rate, but lower overweight and obesity rates, than male Tibetan students. BMI increases with age for male students but decreases with age for female students. Male Uygur students show higher obesity rate than female Uygur students. Tibetan and Uygur university students have higher BMI than other minorities in South China. PMID:24453807

  13. Separation and Recycling for Rare Earth Elements by Homogeneous Liquid-Liquid Extraction (HoLLE Using a pH-Responsive Fluorine-Based Surfactant

    Directory of Open Access Journals (Sweden)

    Shotaro Saito

    2015-08-01

    Full Text Available A selective separation and recycling system for metal ions was developed by homogeneous liquid-liquid extraction (HoLLE using a fluorosurfactant. Sixty-two different elemental ions (e.g., Ag, Al, As, Au, B, Ba, Be, Bi, Ca, Cd, Ce, Co, Cr, Cu, Dy, Er, Eu, Fe, Ga, Gd, Ge, Hf, Hg, Ho, In, Ir, La, Lu, Mg, Mn, Mo, Nb, Nd, Ni, Os, P, Pb, Pd, Pr, Pt, Re, Rh, Ru, Sb, Sc, Se, Si, Sm, Sn, Sr, Ta, Tb, Te, Ti, Tl, Tm, V, W, Y, Yb, Zn, and Zr were examined. By changing pH from a neutral or alkaline solution (pH ≥ 6.5 to that of an acidic solution (pH < 4.0, gallium, zirconium, palladium, silver, platinum, and rare earth elements were extracted at >90% efficiency into a sedimented Zonyl FSA® (CF3(CF2n(CH22S(CH22COOH, n = 6–8 liquid phase. Moreover, all rare earth elements were obtained with superior extraction and stripping percentages. In the recycling of rare earth elements, the sedimented phase was maintained using a filter along with a mixed solution of THF and 1 M sodium hydroxide aqueous solution. The Zonyl FSA® was filtrated and the rare earth elements were recovered on the filter as a hydroxide. Furthermore, the filtrated Zonyl FSA was reusable by conditioning the subject pH.

  14. Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese.

    Science.gov (United States)

    Li, Jiawei; Zeng, Wen; Zhang, Ye; Ko, Albert Min-Shan; Li, Chunxiang; Zhu, Hong; Fu, Qiaomei; Zhou, Hui

    2017-12-04

    Ancient Di-Qiang people once resided in the Ganqing region of China, adjacent to the Central Plain area from where Han Chinese originated. While gene flow between the Di-Qiang and Han Chinese has been proposed, there is no evidence to support this view. Here we analyzed the human remains from an early Di-Qiang site (Mogou site dated ~4000 years old) and compared them to other ancient DNA across China, including an early Han-related site (Hengbei site dated ~3000 years old) to establish the underlying genetic relationship between the Di-Qiang and ancestors of Han Chinese. We found Mogou mtDNA haplogroups were highly diverse, comprising 14 haplogroups: A, B, C, D (D*, D4, D5), F, G, M7, M8, M10, M13, M25, N*, N9a, and Z. In contrast, Mogou males were all Y-DNA haplogroup O3a2/P201; specifically one male was further assigned to O3a2c1a/M117 using targeted unique regions on the non-recombining region of the Y-chromosome. We compared Mogou to 7 other ancient and 38 modern Chinese groups, in a total of 1793 individuals, and found that Mogou shared close genetic distances with Taojiazhai (a more recent Di-Qiang population), Hengbei, and Northern Han. We modeled their interactions using Approximate Bayesian Computation, and support was given to a potential admixture of ~13-18% between the Mogou and Northern Han around 3300-3800 years ago. Mogou harbors the earliest genetically identifiable Di-Qiang, ancestral to the Taojiazhai, and up to ~33% paternal and ~70% of its maternal haplogroups could be found in present-day Northern Han Chinese.

  15. Prevalence of Diabetes and Associated Factors in the Uyghur and Han Population in Xinjiang, China.

    Science.gov (United States)

    Gong, Haiying; Pa, Lize; Wang, Ke; Mu, Hebuli; Dong, Fen; Ya, Shengjiang; Xu, Guodong; Tao, Ning; Pan, Li; Wang, Bin; Shan, Guangliang

    2015-10-14

    To estimate the prevalence of diabetes and identify risk factors in the Uyghur and Han population in Xinjiang, China. A cross-sectional study in urban and rural areas in Xinjiang, including 2863 members of the Uyghur population and 3060 of the Han population aged 20 to 80 years, was conducted from June 2013 to August 2013. Data on fasting plasma glucose (FPG) and personal history of diabetes were used to estimate the prevalence of diabetes. Data on demographic characteristics, lifestyle risk factors, and lipid profiles were collected to identify risks factors using the multivariate logistic regression model. In urban areas, the age- and gender-standardized prevalence of diabetes was 8.21%, and the age- and gender-standardized prevalence of diabetes was higher in the Uyghur population (10.47%) than in the Han population (7.36%). In rural areas, the age- and gender-standardized prevalence of diabetes was 6.08%, and it did not differ significantly between the Uyghur population (5.71%) and the Han population (6.59%). The results of the multivariate logistic regression analysis showed that older age, obesity, high triglycerides (TG), and hypertension were all associated with an increased risk of diabetes in the Uyghur and Han population. Urban residence and low high-density lipoprotein cholesterol (HDL-C) were associated with an increased risk of diabetes in the Uyghur population. Being an ex-drinker was associated with an increased risk of diabetes and heavy physical activity was associated with a decreased risk of diabetes in the Han population. Our study indicates that diabetes is more prevalent in the Uyghur population compared with the Han population in urban areas. Strategies aimed at the prevention of diabetes require ethnic targeting.

  16. Prevalence of Diabetes and Associated Factors in the Uyghur and Han Population in Xinjiang, China

    Directory of Open Access Journals (Sweden)

    Haiying Gong

    2015-10-01

    Full Text Available Objective: To estimate the prevalence of diabetes and identify risk factors in the Uyghur and Han population in Xinjiang, China. Methods: A cross-sectional study in urban and rural areas in Xinjiang, including 2863 members of the Uyghur population and 3060 of the Han population aged 20 to 80 years, was conducted from June 2013 to August 2013. Data on fasting plasma glucose (FPG and personal history of diabetes were used to estimate the prevalence of diabetes. Data on demographic characteristics, lifestyle risk factors, and lipid profiles were collected to identify risks factors using the multivariate logistic regression model. Results: In urban areas, the age- and gender-standardized prevalence of diabetes was 8.21%, and the age- and gender-standardized prevalence of diabetes was higher in the Uyghur population (10.47% than in the Han population (7.36%. In rural areas, the age- and gender-standardized prevalence of diabetes was 6.08%, and it did not differ significantly between the Uyghur population (5.71% and the Han population (6.59%. The results of the multivariate logistic regression analysis showed that older age, obesity, high triglycerides (TG, and hypertension were all associated with an increased risk of diabetes in the Uyghur and Han population. Urban residence and low high-density lipoprotein cholesterol (HDL-C were associated with an increased risk of diabetes in the Uyghur population. Being an ex-drinker was associated with an increased risk of diabetes and heavy physical activity was associated with a decreased risk of diabetes in the Han population. Conclusions: Our study indicates that diabetes is more prevalent in the Uyghur population compared with the Han population in urban areas. Strategies aimed at the prevention of diabetes require ethnic targeting.

  17. Genetic polymorphisms of 18 short tandem repeat loci in 3550 individuals from the Han population of Changchun, Northeast China.

    Science.gov (United States)

    Feng, Zhen; Xia, Mingying; Bao, Helai; Wang, Linlin; Jin, Li; Li, Liming; Li, Shilin

    2016-11-01

    In this study, we analyzed 18 autosomal STRs on 3550 unrelated individuals collected from the Han population of Changchun. No significant deviation from Hardy-Weinberg equilibrium was observed at all STR loci, and the expected heterozygosity ranged from 0.6275 to 0.9207. The combined match probability (CMP) was 2.42 × 10 - 22 , and the combined power of discrimination (CPD) was 99.9999999999999999999758 %. Changchun Han showed no significant difference between northern and eastern Han populations at nearly all STR loci, but had significant differences between southern Han at multiple STRs, as well as other Chinese ethnic populations. The phylogenetic analysis also showed that Changchun Han is genetically close to northern Hans, suggesting that the Han population of Changchun could mainly come from northern China.

  18. Som i et spejl - Hans Egede-receptionen gennem tre hundrede år

    DEFF Research Database (Denmark)

    Kjærgaard, Kathrine

    2008-01-01

    stor, og længe ville man ikke vide af Hans Egede, der - skønt født i Norge - opfattedes som dansk. Først efter 1945, hvor Norge i kølvandet på Danskehjælpen under Anden Verdenskrig omsider forsonede sig med Danmark, tog man atter Hans Egede til sig. Blandt større mindesmærker, som er blevet til siden...... 1945, kan nævnes Nicolai Schiølls ungdommelige statue af grønlandsmissionæren i det centrale Oslo (1965) og Axel Revolds monumentale udskmykning af kirken i Hans Egedes nordnorske fødeby Harstad (1958). I Danmark, hvor sorgen over tabet af Norge var stor, var man i årene efter 1814 meget...... tilbageholdende med at omklamre tidligere norske landsmænd som Hans Egede. Først hen mod slutningen af 1800-tallet begyndte forbeholdene at smelte et efter et. Den definitive omdefinering af den dansk-norske 1700-tals patriot til national dansk kirkefyrste kom med opstillingen 1913 af hans statue ved Marmorkirken...

  19. Prognostic analysis and comparison of colon cancer in Han and Hui patients.

    Science.gov (United States)

    Zhang, Mei; Zhao, Qu-Chuan; Liu, Yan-Peng; Yang, Lei; Zhu, Hong-Ming; Chhetri, Jagadish K

    2014-05-07

    To investigate the relevant prognostic factors and their differences between colorectal cancer (CRC) patients of Chinese Han and Hui ethnicities in the Beijing region. A retrospective analysis of 880 patients diagnosed with CRC at Xuanwu Hospital, Capital Medical University between September 2001 and September 2011 was performed. Among the 880 patients, 398 and 482 were Hui and Han, respectively. Characteristics including sex, age, diet, tumor size, primary tumor site, Dukes' stage and degree of differentiation were analyzed for their influence on prognosis. Data on dietary structures were recorded through a questionnaire survey conducted during the patient's first visit, return visit or follow-up checkups. Among patients with colon cancer, the 5-year survival rate for patients of Hui ethnicity was lower than that for Han patients (P = 0.025). Six risk factors (age of onset, dietary structure, tumor size, Dukes' stage, location of cancer and degree of differentiation) in both Han and Hui patients were identified as prognostic factors (P dietary structure was a statistically significant factor, and diet varied significantly between the two ethnic groups. Dietary structure has a significant influence on colon cancer prognosis among Han and Hui patients with colon cancer in Beijing, which may cause a difference in their survival rates.

  20. Analysis of CYP3A4 genetic polymorphisms in Han Chinese.

    Science.gov (United States)

    Zhou, Qing; Yu, Xiaomin; Shu, Chang; Cai, Yimei; Gong, Wei; Wang, Xumin; Wang, Duen-mei; Hu, Songnian

    2011-06-01

    Our study aimed to comprehensively investigate the genetic polymorphisms of CYP3A4 in Han Chinese. We sequenced the gene regions of CYP3A4, including its promoter, exons, surrounding introns and 3' untranslated region (3'UTR), from 100 unrelated-healthy Han Chinese individuals. We detected 11 SNPs, three of which are novel. According to in silico functional prediction of novel variants, 20148 A>G in exon 10, resulting in substitution of Tyr319 with Cys (CYP3A4*21), may induce dramatic alteration of protein conformation, and 26908 G>A in 3'UTR may disrupt post-transcriptional regulation. We identified five alleles in Han Chinese, the allele frequencies of CYP3A4*1, *5, *6, *18 and *21 are 97, 0.5, 1, 1 and 0.5%, respectively. Haplotype inference revealed 14 haplotypes, of which the major haplotype CYP3A4*1A constitutes 59% of the total chromosomes. We also examined the possible role of natural selection in shaping the variation of CYP3A4 and confirmed a trend, consistent with the action of positive selection. We systematically screened the genetic polymorphisms of CYP3A4 in Han Chinese, highlighted possible functional impairment of the novel allele and summarized the distinct allele and haplotype frequency distribution, with an emphasis on detecting the footprint of recent positive selection on the CYP3A4 gene in Han Chinese.

  1. Attachment and sibling rivalry in Little Hans: the fantasy of the two giraffes revisited.

    Science.gov (United States)

    Wakefield, Jerome C

    2007-01-01

    Freud's interpretation of Little Hans's "phantasy of the two giraffes" is pivotal to his oedipal analysis that Hans has inchoate desires for sexual intercourse with his mother. Bowlby argued that Freud's focus on his oedipal theory led him to ignore preoedipal attachment-related factors that have equal plausibility in explaining the clinical data. However, Bowlby did not attempt to apply the attachment perspective to the interpretation of Hans's fantasies that form the core of the case material. A microanalysis of Hans's giraffe fantasy and the evidence used to support Freud's claims about it yields an attachment-based sibling rivalry account arguably of greater explanatory power than the oedipal account. Consistent with Bowlby's hypothesis, the evidence suggests that Hans's giraffe fantasy is about the sibling rivalry triangle involved in caregiver attachment access, rather than (or in addition to) the oedipal triangle. The issue of multiple levels of meaning and the methodological challenges raised by multiple determination is also considered. The giraffe fantasy's attachment-theoretic explanation encourages a rethinking of this classic case and strengthens Bowlby's claim that the case is fruitfully viewed from an attachment perspective.

  2. Eesti Vabariigi põhiseadus : kommenteeritud väljaanne / toimetuskolleegium: Eerik-Juhan Truuväli, Berit Aaviksoo, Oliver Kask, Lasse Lehis, Lauri Madise, Ülle Madise, Kalle Merusk, Lauri Mälksoo, Raul Narits, Vallo Olle, Peep Pruks

    Index Scriptorium Estoniae

    2008-01-01

    Kommentaaride autorid ja sisu: Sissejuhatus / Raul Narits, Lauri Madise, Heinrich Schneider. Preambul / Raul Narits, Heinrich Schneider. I ptk. / Kalle Merusk, Taavi Annus, Madis Ernits, Heiki Lindpere, Lauri Madise. II ptk. / Oliver Kask, Madis Ernits, Taavi Annus, Peeter Roosma, Rait Maruste, Eerik Kergandberg, Ivo Pilving, Uno Lõhmus, Merilin Kiviorg, Einar Vene, Ülle Madise. III ptk. / Oliver Kask. IV ptk. / Lauri Madise, Aaro Mõttus, Jüri Põld, Tiina Runthal. V ptk. / Eerik-Juhan Truuväli, Ülle Madise, Jüri Põld, Urmas Reinsalu. VI ptk. / Kalle Merusk, Jüri Põld. VII ptk. / Eerik-Juhan Truuväli, Jüri Liventaal, Jüri Põld. VIII ptk. / Lasse Lehis. IX ptk. / Kristi Land, Heiki Lindpere, Lauri Madise, Heiki Pisuke. X ptk. / Oliver Kask, Enn Markvart, Jüri Põld. XI ptk. / Ülle Madise, Janek Laidvee, Heinrich Schneider. XII ptk. / Berit Aaviksoo, Mihkel Allik, Enn Markvart, Raul Narits, Aare Reenumägi, Peeter Roosma. XIII ptk. / Raul Narits, Uno Lõhmus, Madis Ernits, Jüri Põld. XIV ptk. / Vallo Olle, Arno Almann, Jüri Liventaal, Ülle Madise. XV ptk. / Eerik-Juhan Truuväli, Aaro Mõttus. Eesti Vabariigi põhiseaduse rakendamise seadus / Oliver Kask, Raul Narits, Peeter Roosma. Eesti Vabariigi põhiseaduse täiendamise seadus / Berit Aaviksoo, Julia Laffranque, Ülle Madise, Jüri Põld. Eesti Vabariigi põhiseadus 1990-2008 : bibliograafia (seisuga september 2008) / koost. Maia Ruttu

  3. Association of ghrelin polymorphisms with metabolic syndrome in Han Nationality Chinese.

    Science.gov (United States)

    Xu, Ling-Ling; Xiang, Hong-Ding; Qiu, Chang-Chun; Xu, Qun

    2008-06-01

    To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. A total of 240 patients with metabolic syndrome and 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism analysis. The allelic frequency of the Leu72Met polymorphism was 17.3% in the patient group and 11.9% in the control group (chi2 = 7.36, P = 0.007). Metabolic syndrome was more prevalent among carriers of the Met72 variant (43.8 vs 33.1%, age- and sex-adjusted odds ratio = 1.57, P = 0.01). No Arg51Gln variants were found in our study subjects. Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Han Nationality Chinese.

  4. Comparison of Genetic Variants in Cancer-Related Genes between Chinese Hui and Han Populations.

    Directory of Open Access Journals (Sweden)

    Chaoyong Tian

    Full Text Available The Chinese Hui population, as the second largest minority ethnic group in China, may have a different genetic background from Han people because of its unique demographic history. In this study, we aimed to identify genetic differences between Han and Hui Chinese from the Ningxia region of China by comparing eighteen single nucleotide polymorphisms in cancer-related genes.DNA samples were collected from 99 Hui and 145 Han people from the Ningxia Hui Autonomous Region in China, and SNPs were detected using an improved multiplex ligase detection reaction method. Genotyping data from six 1000 Genomes Project population samples (99 Utah residents with northern and western European ancestry (CEU, 107 Toscani in Italy (TSI, 108 Yoruba in Ibadan (YRI, 61 of African ancestry in the southwestern US (ASW, 103 Han Chinese in Beijing (CHB, and 104 Japanese in Tokyo (JPT were also included in this study. Differences in the distribution of alleles among the populations were assessed using χ2 tests, and FST was used to measure the degree of population differentiation.We found that the genetic diversity of many SNPs in cancer-related genes in the Hui Chinese in Ningxia was different from that in the Han Chinese in Ningxia. For example, the allele frequencies of four SNPs (rs13361707, rs2274223, rs465498, and rs753955 showed different genetic distributions (p0.000 between the Hui and Han populations.These results suggest that some SNPs associated with cancer-related genes vary among different Chinese ethnic groups. We suggest that population differences should be carefully considered in evaluating cancer risk and prognosis as well as the efficacy of cancer therapy.

  5. Assessing genome-wide copy number variation in the Han Chinese population.

    Science.gov (United States)

    Lu, Jianqi; Lou, Haiyi; Fu, Ruiqing; Lu, Dongsheng; Zhang, Feng; Wu, Zhendong; Zhang, Xi; Li, Changhua; Fang, Baijun; Pu, Fangfang; Wei, Jingning; Wei, Qian; Zhang, Chao; Wang, Xiaoji; Lu, Yan; Yan, Shi; Yang, Yajun; Jin, Li; Xu, Shuhua

    2017-10-01

    Copy number variation (CNV) is a valuable source of genetic diversity in the human genome and a well-recognised cause of various genetic diseases. However, CNVs have been considerably under-represented in population-based studies, particularly the Han Chinese which is the largest ethnic group in the world. To build a representative CNV map for the Han Chinese population. We conducted a genome-wide CNV study involving 451 male Han Chinese samples from 11 geographical regions encompassing 28 dialect groups, representing a less-biased panel compared with the currently available data. We detected CNVs by using 4.2M NimbleGen comparative genomic hybridisation array and whole-genome deep sequencing of 51 samples to optimise the filtering conditions in CNV discovery. A comprehensive Han Chinese CNV map was built based on a set of high-quality variants (positive predictive value >0.8, with sizes ranging from 369 bp to 4.16 Mb and a median of 5907 bp). The map consists of 4012 CNV regions (CNVRs), and more than half are novel to the 30 East Asian CNV Project and the 1000 Genomes Project Phase 3. We further identified 81 CNVRs specific to regional groups, which was indicative of the subpopulation structure within the Han Chinese population. Our data are complementary to public data sources, and the CNV map may facilitate in the identification of pathogenic CNVs and further biomedical research studies involving the Han Chinese population. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  6. The Rolf and Gertrud Dahlgren Prize for 2017 Awarded to Hans Walter Lack

    DEFF Research Database (Denmark)

    Friis, Ib

    2018-01-01

    The reasons for awarding the Rolf and Gertrud Dahlgren Prize to Hans Walter Lack are summarised and the prize described. It is also mentioned that Rosén's Linnaeus Medal in Gold was awarded to Arne Strid at the same ceremony.......The reasons for awarding the Rolf and Gertrud Dahlgren Prize to Hans Walter Lack are summarised and the prize described. It is also mentioned that Rosén's Linnaeus Medal in Gold was awarded to Arne Strid at the same ceremony....

  7. DVD. Piret Tamm soovitab : "Mootorrattapäevikud" / Piret Tamm

    Index Scriptorium Estoniae

    Tamm, Piret, 1966-

    2006-01-01

    Mängufilm Che Guevarast "Mootorratta päevikud" ("Diarios de motocicleta") : režissöör Walter Salles : Ameerika Ühendriigid - Saksamaa - Suurbritannia - Argentiina - Tšiili - Peruu 2004. Kriitikat ka firma V&K Holding DVD kvaliteedi kohta

  8. Quantitative Analysis of Intestinal Flora of Uygur and Han Ethnic Chinese Patients with Ulcerative Colitis

    Directory of Open Access Journals (Sweden)

    Ping Yao

    2016-01-01

    Full Text Available Aim. To study the correlation between intestinal flora and ulcerative colitis by analyzing the abundance of Bacteroides, Fusobacterium, Clostridium, Bifidobacterium spp., and Faecalibacterium prausnitzii in the intestinal of ulcerative colitis (UC patients and healthy controls with Uygur and Han ethnic. Methods. Bacterial genomic DNA was extracted from fecal samples and analyzed with real-time fluorescence quantitative polymerase chain reaction (PCR to identify the abundance of Bacteroides, Fusobacterium, Clostridium, Bifidobacterium spp., and Faecalibacterium prausnitzii. Results. The samples from UC patients, Uygur and Han ethnic combined, had higher abundance of Bacteroides (P=0.026 but lower Clostridium (P=0.004, Bifidobacterium spp. (P=0.009, and Faecalibacterium prausnitzii (P=0.008 than those from healthy controls. Among UC patients, Bacteroides population was raised in acute UC patients (P≤0.05, while the abundance of Clostridium, Bifidobacterium spp., Fusobacterium, and Faecalibacterium prausnitzii decreased (P≤0.05 compared with the remission. In both UC patients group and control group, no difference was observed in the abundance of these 5 bacteria between the Han and the Uygur group. Conclusions. Variations in the abundance of these five bacterial strains in intestines may be associated with the occurrence of UC in Uygur and Han populations; however, these variations were not associated with ethnic difference.

  9. Population genetics of 26 Y-STR loci for the Han ethnic in Hunan province, China.

    Science.gov (United States)

    Jiang, Weibo; Gong, Zheng; Rong, Haibo; Guan, Hua; Zhang, Tao; Zhao, Yihe; Fu, Xiaoliang; Zha, Lagabaiyila; Jin, Chuan; Ding, Yanjun

    2017-01-01

    To study the population data of Y-chromosome STRs (Y-STRs) of Han population resided in Hunan province, we analyzed haplotypes of 26 Y-STRs (DYS19, DYS385a/b, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS481, DYS533, DYS549, DYS570, DYS576, DYS635, DYS643, DYS388, DYS449, DYS460, and YGATAH4) in 310 unrelated male individuals using a commercially available Goldeneye® DNA ID 26Y system. The calculated average gene diversity values ranged from 0.4211 to 0.9590 for DYS438 and DYS385a/b loci, respectively. The discriminatory capacity was 96.77 % with 300 observed haplotypes. Population relationships between Hunan Han and eight other populations available from Y-chromosome haplotype reference database (YHRD) were compared. The results showed that the Han population resided in the Hunan district is significantly different from other populations. Our results also indicated that these 26 Y-STR loci were highly genetically polymorphic in the Hunan Han population and of great value in forensic application.

  10. Population genetic data of Investigator HDplex markers in Han population from Southern China.

    Science.gov (United States)

    Liu, Qiuling; Nan, Hailun; He, Xin; Wu, Weiwei; Lu, Dejian

    2018-02-17

    Allele frequencies and forensic statistical parameters for 12 STRs contained in the Investigator HDplex Kit (D2S1360, D3S1744, D4S2366, D5S2500, SE33, D6S474, D7S1517, D8S1132, D10S2325, D12S391, D18S51, and D21S2055) were estimated from a sample of 503 unrelated individuals from the Guangdong Han population of South China. No significant departure from the Hardy-Weinberg equilibrium or genetic linkage disequilibrium was observed (after Bonferroni correction). The expected heterozygosity ranged from 0.6411 to 0.9414. The allele frequencies in Guangdong Han significantly differed from that in Shanghai Han, Korea, Northern Italian, Swedish, Dutch, Somalia, and Argentinean populations at 2 to 12 loci. The markers included in the kit have highly polymorphic information that could be used for forensic DNA analysis as potential tools for differentiating Han population from other populations in the world.

  11. Genetic variants at 20p11 confer risk to androgenetic alopecia in the Chinese Han population.

    Directory of Open Access Journals (Sweden)

    Bo Liang

    Full Text Available BACKGROUND: Androgenetic alopecia (AGA is a well-characterized type of progressive hair loss commonly seen in men, with different prevalences in different ethnic populations. It is generally considered to be a polygenic heritable trait. Several susceptibility genes/loci, such as AR/EDA2R, HDAC9 and 20p11, have been identified as being involved in its development in European populations. In this study, we aim to validate whether these loci are also associated with AGA in the Chinese Han population. METHODS: We genotyped 16 previously reported single nucleotide polymorphisms (SNPs with 445 AGA cases and 546 healthy controls using the Sequenom iPlex platform. The trend test was used to evaluate the association between these loci and AGA in the Chinese Han population. Conservatively accounting for multiple testing by the Bonferroni correction, the threshold for statistical significance was P ≤ 3.13 × 10(-3. RESULTS: We identified that 5 SNPs at 20p11 were significantly associated with AGA in the Chinese Han population (1.84 × 10(-11 ≤ P ≤ 2.10 × 10(-6. CONCLUSIONS: This study validated, for the first time, that 20p11 also confers risk for AGA in the Chinese Han population and implicated the potential common genetic factors for AGA shared by both Chinese and European populations.

  12. BREVES CONSIDERAÇÕES SOBRE A TEORIA PURA DE HANS KELSEN

    OpenAIRE

    Siqueira, Dirceu Pereira; Instituição Toledo de Ensino; Botelho, Marcos César; Instituição Toledo de Ensino

    2012-01-01

    O presente artigo visa discutir os principais aspectos da teoria pura de Hans Kelsen, tratando, especificamente, de dois pontos fundamentais de sua teoria, a saber, a estática jurídica e a dinâmica jurídica, objetivando fornecer um delineamento geral do modelo proposto pelo mestre de Viena.

  13. Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population.

    Science.gov (United States)

    Gu, Maolin; Qiu, Jing; Guo, Daoxia; Xu, Yunfang; Liu, Xingxiang; Shen, Chong; Dong, Chen

    2018-03-20

    Recent GWAS-associated studies reported that single nucleotide polymorphisms (SNPs) in ABCB1, TGFβ1, XRCC1 genes were associated with hepatitis A virus (HAV) infection, and variants of APOA4 and APOE genes were associated with and hepatitis E virus (HEV) infection in US population. However, the associations of these loci with HAV or HEV infection in Chinese Han population remain unclear. A total of 3082 Chinese Han persons were included in this study. Anti-HAV IgG and anti-HEV IgG were detected by enzyme-linked immunosorbent assay (ELISA). Genotypes in ABCB1, TGFβ1, XRCC1, APOA4 and APOE SNPs were determined by TaqMan MGB technology. In Chinese Han population, rs1045642 C to T variation in ABCB1 was significantly associated with the decreased risk of HAV infection (P infection in our samples (P C to T variation in APOE was significantly associated with lower risk of HEV infection in males (adjusted OR infection. Additionally, Chinese Han males with rs7412 C to T variation in APOE gene are less prone to be infected by HEV.

  14. But Hans Kelsen was not born in Africa: a reply to Thaddeus Metz ...

    African Journals Online (AJOL)

    I argue that Metz's undertaking, in seeking a 'comprehensive basic norm' to underpin African ethics, is similar to Hans Kelsen's postulation of the Grundnorm in his Pure Theory of Law. But African ethics does not need to be underpinned by an approach such as Kelsen's. In my view, Metz's preference for seeking to develop ...

  15. Brief Report: No Increase in Criminal Convictions in Hans Asperger's Original Cohort

    Science.gov (United States)

    Hippler, Kathrin; Viding, Essi; Klicpera, Christian; Happe, Francesca

    2010-01-01

    Hans Asperger originally used the term "autistic psychopathy" to describe his patients on the autism spectrum, leading to a possible confusion with psychopathic disorder and delinquent behaviour. We conducted a penal register search for 177 former patients of Asperger's clinic with a childhood diagnosis of "autistic…

  16. Collaboration, Reputation, and Ethics in American Academic Life: Hans H. Gerth and C. Wright Mills.

    Science.gov (United States)

    Oakes, Guy; Vidich, Arthur J.

    Using the collaboration between sociologist C. Wright Mills and Hans H. Gerth and their studies of the work of Max Weber as a point of departure for a sustained discussion of academic ethics, this book explores how concealment, secrecy, and deception contribute to the building of academic reputation and how the balance of knowledge and power in a…

  17. "Metaphorically Speaking" - Begriffsgeschichte and Hans Blumenberg's Metaphorologie

    DEFF Research Database (Denmark)

    Lassen, Frank Beck

    2010-01-01

      Ever since Hans Blumenberg coined the term Metaphorologie (metaphorology) in 1960 to indicate a specific line of historical inquiry, parallel to those undertaken within Begriffsgeschichte (conceptual history), the relationship between the two has been one of tension. In 1992, upon completion of...

  18. 'Presence' of the past in the presence (Hans Ulrich Gumbrecht, Eelco Runia)

    NARCIS (Netherlands)

    ter Schure, L

    2006-01-01

    In recent writings historian Eelco Runia (Groningen) and literary theorist Hans Ulrich Gumbrecht (Stanford) have introduced the notion of presence, a new and promising way of thinking about history. Although there are differences between the two authors, both think of presence as the antithesis of

  19. Single Nucleotide Polymorphisms in the HIRA Gene Affect Litter Size in Small Tail Han Sheep

    Directory of Open Access Journals (Sweden)

    Mei Zhou

    2018-05-01

    Full Text Available Maintenance of appropriate levels of fecundity is critical for efficient sheep production. Opportunities to increase sheep litter size include identifying single gene mutations with major effects on ovulation rate and litter size. Whole-genome sequencing (WGS data of 89 Chinese domestic sheep from nine different geographical locations and ten Australian sheep were analyzed to detect new polymorphisms affecting litter size. Comparative genomic analysis of sheep with contrasting litter size detected a novel set of candidate genes. Two SNPs, g.71874104G>A and g.71833755T>C, were genotyped in 760 Small Tail Han sheep and analyzed for association with litter size. The two SNPs were significantly associated with litter size, being in strong linkage disequilibrium in the region 71.80–71.87 Mb. This haplotype block contains one gene that may affect litter size, Histone Cell Cycle Regulator (HIRA. HIRA mRNA levels in sheep with different lambing ability were significantly higher in ovaries of Small Tail Han sheep (high fecundity than in Sunite sheep (low fecundity. Moreover, the expression levels of HIRA in eight tissues of uniparous Small Tail Han sheep were significantly higher than in multiparous Small Tail Han sheep (p < 0.05. HIRA SNPs significantly affect litter size in sheep and are useful as genetic markers for litter size.

  20. Bronzino and a bronze boar. Hans Christian Andersen and Stendhal in nineteenth-century Florence

    NARCIS (Netherlands)

    Klerck, A.R. de

    2015-01-01

    Bronzino e il porcellino: Hans Christian Andersen e Stendhal nella Firenze del XIX secolo La storia dell’arte dell’Ottocento non sembra aver avuto particolarmente a cuore gli artisti italiani delle generazioni successive ai grandi maestri rinascimentali, quali Raffaello e Michelangelo. Così, ad

  1. Hans Alberts Christentumskritik : Ein kritischer vergleich zwischen Alberts kritik und klassischen religionskritiken

    NARCIS (Netherlands)

    Grube, Dirk Martin

    2002-01-01

    In this article, it is argued that Hans Albert's criticism of Christianity is stronger than the logical positivist as well as the classical, e.g. Feuerbachian, criticism, since it rests on less questionable presuppositions. Other than those other forms of criticism, it does not presuppose an

  2. Resolution Enhancement Algorithm for Spaceborn SAR Based on Hanning Function Weighted Sidelobe Suppression

    Science.gov (United States)

    Li, C.; Zhou, X.; Tang, D.; Zhu, Z.

    2018-04-01

    Resolution and sidelobe are mutual restrict for SAR image. Usually sidelobe suppression is based on resolution reduction. This paper provide a method for resolution enchancement using sidelobe opposition speciality of hanning window and SAR image. The method can keep high resolution on the condition of sidelobe suppression. Compare to traditional method, this method can enchance 50 % resolution when sidelobe is -30dB.

  3. Prevalence and Risk Factors of Infertility for Han, Uygur, and Kazakh Ethnicities in Xinjiang Rural Residents.

    Science.gov (United States)

    Zhao, Jing; Wang, Songfeng; Gao, Qi; Cai, Xia; La, Xiaolin

    2015-01-01

    To estimate the prevalence and associated factors of current infertility for Han, Uygur, and Kazakh ethnicities in Xinjiang rural residents. Chinese Uygur, Kazakh, and Han populations represent > 90% of the total population of the Xinjiang Uygur Autonomous Region, and their customs, culture, and food consumption are different. The effect of ethnic differences on infertility risk factors is rarely studied. A cross-sectional study of 5,086 married and common-law couples, with a female partner aged 18-49, living in Hami, Kuche, or Xinyuan counties in Xinjiang, China. General information for the study subjects, including demographic characteristics, life customs, sexual history, history of contraception use, and history of disease, was collected by questionnaire. General health, gynecologic examinations, and sociodemographic characteristics were also carried out. A total of 5,086 females from Xinjiang Province were surveyed, including 493 with infertility. The standardized prevalence rate of infertility was 9.7% (95% CI 8.9-10.5), and the prevalence of infertility in Han, Uygur, and Kazakh ethnicities was 6.8% (95% CI 5.7-7.9), 10.9% (95% CI 8.0-13.8), and 10.1% (95% CI 7.4-12.8), respectively. The present study suggests that the prevalence of infertility was lower in the Han as compared to the Kazakh and Uygur ethnicities.

  4. Building Empire through Argumentation: Debating Salt and Iron in Western Han China

    Science.gov (United States)

    You, Xiaoye

    2010-01-01

    The history of American imperialism, as well as China's strong presence on the contemporary global scene, should encourage American scholars of rhetoric to look beyond the nation-state and study other rhetorical traditions such as Chinese practices of argument. A debate during the Western Han dynasty over the country's economic policies…

  5. [Polymorphism analysis of 20 autosomal short-tandem repeat loci in southern Chinese Han population].

    Science.gov (United States)

    Chen, Ling; Lu, Hui-Jie; DU, Wei-An; Qiu, Ping-Ming; Liu, Chao

    2016-02-20

    To evaluate the value of PowerPlex ® 21 System (Promega) and study the genetic polymorphism of its 20 short-tandem repeat (STR) loci in southern Chinese Han population. We conducted genotyping experiments using PowerPlex ® 21 System on 20 autosomal STR loci (D3S1358, D1S1656, D6S1043, D13S317, Penta E, D16S539, D18S51, D2S1338, CSF1PO, Penta D, TH01, vWA, D21S11, D7S820, D5S818, TPOX, D8S1179, D12S391, D19S433 and FGA) in 2367 unrelated Chinese Han individuals living in South China. The allele frequencies and parameters commonly used in forensic science were statistically analyzed in these individuals and compared with the reported data of other populations. The PowerPlex ® 21 System had a power of discrimination (PD) ranging from 0.7839 to 0.9852 and a power of exclusion (PE) ranging from 0.2974 to 0.8099 for the 20 loci. No significant deviation from Hardy-Weinberg expectations was found for all the loci except for D5S818. This southern Chinese Han population had significant differences in the allele frequencies from 8 ethnic groups reported in China, and showed significant differences at 8 to 20 STR foci from 5 foreign populations. The allele frequency at the locus D1S1656 in this southern Chinese Han population differed significantly from those in the 5 foreign populations and from 3 reported Han populations in Beijing, Zhejiang Province and Fujian Province of China. The neighbor-joining phylogenetictree showed clustering of all the Asian populations in one branch, while the northern Italian and Argentina populations clustered in a separate branch. This southern Chinese Han population had the nearest affinity with the Yi ethnic population in Yunnan Province of China. The 20 STR loci are highly polymorphic in this southern Chinese Han population, suggesting the value of this set of STR loci in forensic personal identification, paternity testing and anthropological study.

  6. Postuumne Bourdieu : Bourdieu / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2005-01-01

    Ka 2003. a. ilmunud Pierre Bourdieu' (1930-2002) fotoalbumist "Alžeeria pildid" (Images d'Algerie: Une affinite elective), kuhu on P. Bourdieu poolt 1958-1961 Alžeerias jäädvustatud mustvalgetest fotodest valitud ligemale 150. 2003. a. korraldati P. Bourdieu fotode põhjal Araabia Maailma Instituudis Pariisis näitus

  7. Plaadid / Heili Vaus-Tamm

    Index Scriptorium Estoniae

    Vaus-Tamm, Heili, 1961-

    2003-01-01

    Uutest plaatidest Keith Jarret/Gary Peacock/Jack DeJohnette "Up for it", Wladislaw Szpilman "The original recordings of the pianist", Emanuel Ax "Haydn Piano Sonatas", Ravi Coltrane "Mad 6", Guano Apes "Walking On A Thin Line", Will Young "From Now On", Janis Joplin "The Essential"

  8. Kuidas lennates kirjutada / Marko Tamm

    Index Scriptorium Estoniae

    Tamm, Marko

    2003-01-01

    Arvustus: Saint-Exupéry, Antoine de. Lõuna postilennuk : [romaan] / prantsuse keelest tõlkinud Merike Riives ; Inimeste maa : [romaan] / prantsuse keelest tõlkinud Merike Riives ja Maria Hange. [Tallinn] : Varrak, 2003; Schiff, Stacy. Antoine de Saint-Exupéry : [prantsuse kirjanik : 1900-1944] / tõlkinud [ja eessõna:] Lia Rajandi. [Tallinn] : Varrak, 2003

  9. Plaadid / Heili Vaus-Tamm

    Index Scriptorium Estoniae

    Vaus-Tamm, Heili, 1961-

    2003-01-01

    Uutest plaatidest The Dowland Project "Care-charming sleep John Potter", Clem Snide "Soft Spot", Deep Purple " Bananas", Don Johnson Big Band "Breaking Daylight", Duetto "Marcelo Alvarez, Salvatore Licitra", Sting "Sacred Love", Travis "12 Memories"

  10. Muusika / Heili Vaus-Tamm

    Index Scriptorium Estoniae

    Vaus-Tamm, Heili, 1961-

    2006-01-01

    EMTAs tutvustati 17. I sihtasutuse Eesti Rahvuslik Klaverimuuseum arengukava projekti. Eri Klas juhats 12. ja 13. I Kanadas Ottowas orkestrit The National Arts Centre Orchestra. Dirigent Arvo Volmer on kutsutud Hollandisse juhatama Brabanti sümfooniaorkestri kontserti. 18. I kõlas Tüüri Tshellokontsert Berliinis. ERSO tähisatb oma 80. sünnipäeva 18. XII

  11. Plaadid / Jürgen Tamme

    Index Scriptorium Estoniae

    Tamme, Jürgen

    2005-01-01

    Uutest heliplaatidest A Guy Called Gerald "To All Things What They Need", "World Of Mouth", Wet Wet Wet "The Greatest Hits", Martika "Toy Soldiers. The Best Of", Toby Keith "Greatest Hits", Electric Six "Senor Smoke", Static-X "Beneath...Between...Beyond...Rarities", Judas Priest "Angel Of Retribution"

  12. Content and form / Margus Tamm

    Index Scriptorium Estoniae

    Tamm, Margus, 1977-

    2012-01-01

    Eesti Tarbekunsti- ja Disainimuuseumis 21.04.-17.06.2012 toimunud näitusest "Sisu ja vorm I. Kaasaegne Eesti graafiline disain 2001-2011", selle koostamise põhimõtetest. Kuraator Indrek Sirkel. Näituse kataloogist "Sisu ja vorm. II"

  13. Kogemused muudavad maailma / Virge Tamme

    Index Scriptorium Estoniae

    Tamme, Virge

    2010-01-01

    Dream Foundation Eesti korraldas detsembris „Teeviida” noortemessil küsitluse, millest selgus, et tervelt 92% õpilastest on mõelnud välismaal õppimisele. Küsitluse eesmärk oli selgitada välja noorte ootused, lootused ja hirmud seoses välismaale õppima minekuga

  14. Plaadid / Heili Vaus-Tamm

    Index Scriptorium Estoniae

    Vaus-Tamm, Heili, 1961-

    2003-01-01

    Uutest plaatidest "Songs of Debussy and Mozart", Yo La Tango "Summer Sun", Cradle of Filth "Damnation and a Day", Celine Dion "One Heart", Macy Gray "The Trouble With Being Myself", Simply Red "Home", "Fabriclive. 07: John Peel", The Concretes "Licking Fingers"

  15. Kuidas portreteerida koolkonda? / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2017-01-01

    Arvustus: Theoretical schools and circles in the twentieth-century humanities : literary theory, history, philosophy / edited by Marina Grishakova and Silvi Salupere. New York ; London : Routledge, 2015. (Routledge interdisciplinary perspectives on literature ; 42)

  16. Plaadid / Heili Vaus-Tamm

    Index Scriptorium Estoniae

    Vaus-Tamm, Heili, 1961-

    2003-01-01

    Uutest plaatidest "Velvet Legion", "oriental Club", Pink Floyd "Dark Side of the Moon", Operatsioon Õ "...ei mingit modernismi, ei mingit abstraktsionismi", Modern Talking "Universe", "Lullabies From Paris", dave brubeck "The Essential", Matchbox Twenty "More than you think you are", The Essential Igor Stravinsky, Live "Birds of Pray", Mötley Crüe "Greatest Hits", Lordi "Get Heavy"

  17. Plaadid / Heili Vaus-Tamm

    Index Scriptorium Estoniae

    Vaus-Tamm, Heili, 1961-

    2003-01-01

    Uutest plaatidest Andras Schiff "Goldberg Variations", Yes "Remixes", "Chill: Brasil 2", "The Fighting Temptations soundtrack", Wheatus "Hand Over Your Loved Ones", Peaches "Fatherfucker", Chemical Brothers "Singles 93-03"

  18. Inhibitory Control in Speech Comprehension among Dai–Han Bilingual Children

    Directory of Open Access Journals (Sweden)

    Yun Tao

    2017-08-01

    Full Text Available We aimed to investigate differences in inhibitory control ability between proficient and non-proficient Dai–Han bilinguals. Two experiments used a combined stimulus–stimulus and stimulus–response compatibility paradigm for this purpose. Participants were Dai–Han bilingual primary-school students selected from a Dai-speaking town in Yunnan province, China. In Dai language interference condition, participants were asked to complete a picture category task. Results showed that the effect of attentional control for non-proficient bilinguals (NPBs was significantly greater than that for proficient bilinguals (PBs, while the effect of response inhibition was not. This implied that a difference in inhibitory control between PBs and NPBs appeared at the attention control stage when interference by the Dai lexicon emerged. In Han language interference condition, however, participants were also asked to complete the same task. Results showed that the effect of response inhibition for NPBs was significantly greater than that for PBs, but the effect of attentional control was not. This demonstrated that a difference in inhibitory control emerged at the response inhibition stage when interference by the Han lexicon emerged. This pattern of results is opposite to previous researches, which indicated that the difference between PBs and NPBs occurred at the response inhibition stage under first language condition, whereas at the attentional control stage under second language (L2 condition. Based on these, this study suggests that Dai–Han bilinguals showed a remarkable L2 advantage. In addition, results showed that response times (RTs of PBs were faster than RTs of NPBs while confounding variables (e.g., intelligence, etc. were under control. This indicates that the inhibitory control ability of the PBs is superior to that of NPBs in this study.

  19. [Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2010-01-01

    Arvustus: Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu = Chinese language and languages of northern Europe. Beijing : Zhongguo she hui ke xue chu ban she, 2008

  20. Para além da autoconsciência moderna: a historiografia de Hans Ulrich Gumbrecht Beyond modern self-consciousness: the historiography of Hans Ulrich Gumbrecht

    Directory of Open Access Journals (Sweden)

    Valdei Lopes de Araujo

    2006-12-01

    Full Text Available Neste artigo, apresento uma análise dos aspectos historiográficos da obra de Hans Ulrich Gumbrecht. Acompanhado o desenvolvimento de sua teoria da modernidade e das conseqüências dessa teoria para a escrita da história e para a auto-consciência disciplinar. Por fim, proponho uma releitura da história da historiografia através dos dois tipos de culturas propostas por Gumbrecht, ou seja, culturas de sentido e culturas de presença. Argumento que mesmo que a historiografia moderna possa ser caracterizada como predominantemente ancorada na produção de sentido, aspectos centrais de sua história só podem ser explicados através de elementos típicos da produção de presença.This paper analyses some historiographical aspects of Hans Ulrich Gumbrecht's work, particularly his theory of modernity and its consequences to the writing of history and its disciplinary self-conscious. Finally, it is proposed a reinterpretation of the history of historiography based on the distinction between cultures of presence and cultures of meaning. It is argued that despite the fact that the elements of meaning are predominant in the constitution of modern historiography, the forces acting in its constitution cannot be explained without typical elements of a culture of presence.

  1. Homogeneous liquid-liquid extraction (HoLLE) via flotation combined with gas chromatography-flame ionization detection as a very simple, rapid and sensitive method for the determination of fenitrothion in water samples.

    Science.gov (United States)

    Mashayekhi, Hossein Ali

    2013-01-01

    Homogeneous liquid-liquid extraction via flotation assistance (HoLLE-FA) and gas chromatography-flame ionization detection (GC-FID) was presented for the extraction and determination of fenitrothion in water samples. In this work, a rapid, simple and efficient HoLLE-FA method was developed based on applying low-density organic solvents without employing centrifugation. A special extraction cell was designed to facilitate the collection of low-density solvent extraction in the determination of fenitrothion in water samples. The water sample solution was added into an extraction cell that contained an appropriate mixture of extraction and homogeneous solvents. By using air flotation, the organic solvent was collected at the conical part of the designed cell. Under the optimum conditions, the method performance was studied in terms of the linear dynamic range (LDR from 1.0 up to 100 μg L⁻¹), linearity (r² > 0.998), and precision (repeatability extraction and determination of fenitrothion in three different water samples.

  2. Little Hans and attachment theory: Bowlby's hypothesis reconsidered in light of new evidence from the Freud Archives.

    Science.gov (United States)

    Wakefield, Jerome C

    2007-01-01

    Bowlby (1973), applying attachment theory to Freud's case of Little Hans, hypothesized that Hans's anxiety was a manifestation of anxious attachment. However Bowlby's evidence was modest; Hans was threatened by his mother with abandonment, expressed fear of abandonment prior to symptom onset, and was separated from his mother for a short time a year before. Bowlby's hypothesis is reassessed in light of a systematic review of the case record as well as new evidence from recently derestricted interviews with Hans's father and Hans in the Freud Archives. Bowlby's hypothesis is supported by multiple additional lines of evidence regarding both triggers of separation anxiety preceding the phobia (e.g., a funeral, sibling rivalry, moving, getting his own bedroom) and background factors influencing his working model of attachment (mother's psychopathology, intense marital conflict, multiple suicides in mother's family) that would make him more vulnerable to such anxiety. Bowlby's hypothesis is also placed within the context of subsequent developments in attachment theory.

  3. Comparative analysis on genome-wide DNA methylation in longissimus dorsi muscle between Small Tailed Han and Dorper×Small Tailed Han crossbred sheep

    Directory of Open Access Journals (Sweden)

    Yang Cao

    2017-11-01

    Full Text Available Objective The objective of this study was to compare the DNA methylation profile in the longissimus dorsi muscle between Small Tailed Han and Dorper×Small Tailed Han crossbred sheep which were known to exhibit significant difference in meat-production. Methods Six samples (three in each group were subjected to the methylated DNA immunoprecipitation sequencing (MeDIP-seq and subsequent bioinformatics analyses to detect differentially methylated regions (DMRs between the two groups. Results 23.08 Gb clean data from six samples were generated and 808 DMRs were identified in gene body or their neighboring up/downstream regions. Compared with Small Tailed Han sheep, we observed a tendency toward a global loss of DNA methylation in these DMRs in the crossbred group. Gene ontology enrichment analysis found several gene sets which were hypo-methylated in gene-body region, including nucleoside binding, motor activity, phospholipid binding and cell junction. Numerous genes were found to be differentially methylated between the two groups with several genes significantly differentially methylated, including transforming growth factor beta 3 (TGFB3, acyl-CoA synthetase long chain family member 1 (ACSL1, ryanodine receptor 1 (RYR1, acyl-CoA oxidase 2 (ACOX2, peroxisome proliferator activated receptor-gamma2 (PPARG2, netrin 1 (NTN1, ras and rab interactor 2 (RIN2, microtubule associated protein RP/EB family member 1 (MAPRE1, ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2, myomesin 1 (MYOM1, zinc finger, DHHC type containing 13 (ZDHHC13, and SH3 and PX domains 2B (SH3PXD2B. The real-time quantitative polymerase chain reaction validation showed that the 12 genes are differentially expressed between the two groups. Conclusion In the current study, a tendency to a global loss of DNA methylation in these DMRs in the crossbred group was found. Twelve genes, TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3

  4. Genetic variants identified by GWAS was associated with colorectal cancer in the Han Chinese population

    Directory of Open Access Journals (Sweden)

    Hui-Ping Qiao

    2015-01-01

    Full Text Available Aim of Study: Colorectal cancer (CRC, now the third most common cancer across the world, is known to aggregate in families. Recently, genome-wide association studies have identified two single nucleotide polymorphisms (SNP associated with CRC in Caucasians. Materials and Methods: To validate whether the same variations conferred risk to CRC in the Han Chinese population, we genotyped 760 individuals (380 controls and 380 cases samples recruited from the Han Chinese origin. Results: We found rs11987193 in 8p12 (P = 0.0472 after correction, OR = 0.751 was significantly associated with CRC but rs12080929 in 1p33 (P = 0.0650 after correction, OR = 0.750 was not. Conclusion: Our findings supported that rs11987193 is a susceptibility locus for CRC, and gene DUSP4 was possible to play a role in the pathology of CRC.

  5. Association between mitochondrial DNA variations and schizophrenia in the northern Chinese Han population.

    Science.gov (United States)

    Xu, Feng-Ling; Ding, Mei; Yao, Jun; Shi, Zhang-Sen; Wu, Xue; Zhang, Jing-Jing; Pang, Hao; Xing, Jia-Xin; Xuan, Jin-Feng; Wang, Bao-Jie

    2017-01-01

    To determine whether mitochondrial DNA (mtDNA) variations are associated with schizophrenia, 313 patients with schizophrenia and 326 unaffected participants of the northern Chinese Han population were included in a prospective study. Single-nucleotide polymorphisms (SNPs) including C5178A, A10398G, G13708A, and C13928G were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Hypervariable regions I and II (HVSI and HVSII) were analyzed by sequencing. The results showed that the 4 SNPs and 11 haplotypes, composed of the 4 SNPs, did not differ significantly between patient and control groups. No significant association between haplogroups and the risk of schizophrenia was ascertained after Bonferroni correction. Drawing a conclusion, there was no evidence of an association between mtDNA (the 4 SNPs and the control region) and schizophrenia in the northern Chinese Han population.

  6. Safety assessment of Novi Han radioactive waste repository - features, problems, results and perspectives

    International Nuclear Information System (INIS)

    Mateeva, M.

    2000-01-01

    This paper summarizes the work done and the achievements reached in the Novi Han radioactive waste repository safety assessment within the IAEA Model Project 'Increasing the safety of Novi Han radioactive waste repository BUL 4/005'. The overall safety assessment has a wide context, but the work reported here relates only to some details and results concerning the development and implementation of the appropriate methodology approach, model and computer code used for the calculations. Different steps and procedures are included for a better practical understanding of the obtained results during the safety assessment performance. The methodology approach is widely based on an international experience in safety analysis and implemented for evaluation computer code AMBER, which is one of the recommended from the safety assessments experts. (author)

  7. [Association between CISH polymorphisms and susceptibility to chronic hepatitis B in Chinese Han population].

    Science.gov (United States)

    Zhang, Xin; Sun, Xuehua; Zhou, Zhenhua; Li, Man; Gao, Yueqiu

    2014-04-01

    To investigate the association between rs414171 single nucleotide polymorphisms (SNP) of cytokine- inducible src homology 2 domain protein (CISH) and the susceptibility to chronic hepatitis B. A total of 233 Chinese Han patients with chronic hepatitis B and 148 age- and sex-matched healthy controls were enrolled in this case-control study. The SNP rs414171 was genotyped by Sequenom MassArray-IPLEX to analyze the relationship between rs414171 and chronic hepatitis B. The distribution of SNP rs414171 allele and genotype frequencies showed no significant difference between the patients and healthy controls (P>0.05). CISH rs414171 is not significantly associated with the susceptibility to chronic hepatitis B in Chinese Han population.

  8. Image and Role of the Queen Mother of the West in Han Grave Art

    Directory of Open Access Journals (Sweden)

    Nataša VAMPELJ SUHADOLNIK

    2015-12-01

    Full Text Available The present article is a detailed study of the image of an ancient Chinese goddess, The Queen Mother of the West, called Xiwangmu 西王母 in Chinese. In the mythological tradition, Xiwangmu is a goddess who possesses the elixir of immortality and dwells in the western paradise, on the magic mountain Kunlun 崑崙. While her image can be found in mural paintings, and on lacquered objects and bronze mirrors, it appears primarily in the form of relief images on the stones and bricks of grave chambers and temples in the Han (206 BCE–220 CE grave complexes. The literary tradition reveals a multifunctional role of the mother, with her many attributes developing in accordance with the changing values of social and mythological concepts. The article concludes with a detailed discussion of her image and role within the wider cosmological context of Han grave art.

  9. [Polymorphism of PentaD and PentaE STR locus in five Chinese Han population].

    Science.gov (United States)

    Liu, Qiu-ling; Lu, Hui-ling; Lü, De-jian

    2003-01-01

    To obtain the genetic polymorphism data of Guangxi, Hunan, Henan, Sichuan, Taiwang Chinese Han population and compare the polymorphism of PentaD and PentaE STR locus. The two loci was analyzed by using the PowerPlex 16 System. 10 alleles of PentaD and 19 alleles of PentaE were found in the five Han population. PentaD and PentaE have the expected heterozygosity values of 0.7746-0.8047 and 0.9005-0.9219, the polymorphism information content values of 0.7710-0.8025 and 0.8969-0.9176, the discrimination power values of 0.9223-0.9341 and 0.9471-0.9782, the power of exclusion values of 0.5435-0.6325 and 0.6785-0.8465, respectively. The result showed that these two loci were highly informative and suitable for forensic application.

  10. Bong-Han Corpuscles as Possible Stem Cell Niches on the Organ-Surfaces

    Directory of Open Access Journals (Sweden)

    Min Su Kim

    2008-03-01

    Full Text Available Objectives : Showing that Bong-Han corpuscles(BHC are suppliers of the stem cells in adulthood, and the Bong-Han ducts(BHD are transportation routes of stem cells. Methods : BHC and BHD were obtained from the internal organ-surfaces of rats. The sliced BHC and BHD were immunostained with various stem cell markers. Extracellular matrices were also analyzed by immunohistochemistry. Result : The presence of mesenchymal stem cells was confirmed by the expression of Integrin beta 1, Collagen type 1 and Fibronectin. But CD54 was not expressed. The hematopoietic stem cell marker, Thy 1 was strongly expressed. BHDs showed Collagen type 1, Fibronectin, and vWF expression. Conclusion : Both hematopoietic and mesenchymal stem cell markers were expressed strongly in BHC similarly as in bone marrow. An endothelial cell marker(vWF demonstrated the possibility of the stem cell transportation routes of BHD.

  11. Hans-Peter Schultze, a great paleoichthyologist for whom work is synonymous with enjoyment

    Directory of Open Access Journals (Sweden)

    R. Cloutier

    2002-01-01

    Full Text Available In the summer of 1982, Hans-Peter Schultze and Gloria Arratia were invited to a small museum located on a fossiliferous site of the Devonian Escuminac Formation in Miguasha, Quebec, eastern Canada, Hans-Peter was to work with Marius Arsenault, the director of the Miguasha Museum, on the skull of the elpistostegalid Elpistostege watsoni, a species closely related to basal tetrapod. In addition, he went through the collections to describe and measure numerous juvenile specimens of the osteolepiform. Eusthenopteran foordi. As expected, there two projects turned out to be important contributions in lower vertebrate paleontology and systematics: one on the origin of tetrapods (1985, and the second one on growth patterns of a Late Devonian fish (1984. During his visit to Miguasha, Hans-Peter also spent time digging for fossils and drawing numerous specimens in the collection. In addition, in order to help the personnel of the museum to identify some of the Escuminac fished, he created an identification key based on the gross morphology of the scales. For a small group of undergraduate students, hired at the museum during the summer as naturalists, it was a unique opportunity to discuss paleontology with a leading researcher. We were amazed by his willingness to talk to us, even if then most of us only spoke French! For the first time, we were exposed to Hennigian methodology and its usage in vertebrate paleontology during and evening lecture that Hans-Peter prepared for us. His lecture was delightful; it was an intensive course in lower vertebrate anatomy, and an intellectual journey among the philosophers Karl Marx and Karl Popper, the entomologists Willy Hennig and Lars Brundin, and "The Band of Four" (Rosen et al., 1981. It was for most of us our first exposure to science, as it should be done. We were all impressed by his knowledge and above all by his simplicity and friendliness. Two years later I started my Ph.D. at The University of Kansas

  12. Study on measuring social cost of water pollution: concentrated on Han River water system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwang Im; Min, Dong Gee; Chung, Hoe Seong; Lim, Hyun Jeong; Kim, Mee Sook [Korea Environment Institute, Seoul (Korea)

    1999-12-01

    Following the economic development and the progress of urbanization, the damage on water pollution has been more serious but a social cost caused by water pollution cannot be measured. Although the need of water quality preservation is emphasized, a base material for public investment on enhancing water quality preservation is not equipped yet due to the absence of economic values of water resource. Therefore it measured a cost generated by leaving pollution not treated water quality in this study. To measure the usable value of water resource or the cost of water pollution all over the country should include a national water system, but this study is limited on the mainstream of Han River water system from North Han River through Paldang to Chamsil sluice gates. Further study on Nakdong River and Keum River water systems should be done. 74 refs., 4 figs., 51 tabs.

  13. Clever Hans and his effects: Karl Krall and the origins of experimental parapsychology in Germany.

    Science.gov (United States)

    De Sio, Fabio; Marazia, Chantal

    2014-12-01

    Shortly before the outbreak of World War I, the so-called Elberfeld horses, the counting and speaking animals, were among the most debated subjects of the newborn comparative psychology. Yet, they have left little trace in the historiography of this discipline, mostly as an appendix of the more famous Clever Hans. Their story is generally told as the prelude to the triumph of reductionistic experimental psychology. By paying a more scrupulous attention than has so far being done to the second life of Hans, and to the endeavours of his second master, Karl Krall, this article explores the story of the Elberfeld horses as an important, if so far neglected, chapter in the history of experimental parapsychology. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Debating Modernity as Secular Religion: Hans Kelsen’s futile exchange with Eric Voegelin

    DEFF Research Database (Denmark)

    Thomassen, Bjørn

    2014-01-01

    This article reviews the mysterious and recently published last book by Hans Kelsen, “Secular Religion. A Polemic Against the Misinterpretation of Modern Social Philosophy, Science and Politics as ‘New Religions’”, contextualizing it with reference to the little known dialogue between Hans Kelsen...... and Eric Voegelin. The confrontation between Kelsen and Voegelin, two of the most illustrious émigré scholars who found in America their new home, is important to revisit because it touches upon several axes of debate of crucial importance to postwar intellectual history: the religion/secularity debate......, the positivist/anti-positivist debates, and the controversy that also led to the famous Voegelin/Arendt debate: how to read the horrors of totalitarianism into a historical trajectory of modernity. Although the Kelsen/Voegelin exchange ended in failure and bitterness its substance matter goes to the heart...

  15. Role of electrodes in ambient electrolytic decomposition of hydroxylammonium nitrate (HAN) solutions

    OpenAIRE

    Koh, Kai Seng; Chin, Jitkai; Wahida Ku Chik, Tengku F.

    2013-01-01

    Decomposition of hydroxylammonium nitrate (HAN) solution with electrolytic decomposition method has attracted much attention in recent years due to its efficiencies and practicability. However, the phenomenon has not been well-studied till now. By utilizing mathematical model currently available, the effect of water content and power used for decomposition was studied. Experiment data shows that sacrificial material such as copper or aluminum outperforms inert electrodes in the decomposition ...

  16. 50 aastat Euroopa integratsiooni: aeg uueks alguseks / Hans-Gert Pöttering

    Index Scriptorium Estoniae

    Pöttering, Hans-Gert, 1945-

    2007-01-01

    Ilmunud ka: Virumaa Teataja, 23. märts 2007, lk. 1; Pärnu Postimees, 24. märts 2007, lk. 19; Koit, 24. märts 2007, lk. 6; Põhjarannik, 24. märts 2007, lk. 2; Severnoje Poberezhje, 24. märts 2007, lk. 2. Euroopa Parlamendi presidendi Hans-Gert Pötteringi mõtted Euroopa Ühenduse asutamislepingu sõlmimise 50. aastapäeva puhul

  17. Hans-Georg Gadamer’s philosophical hermeneutics: Concepts of reading, understanding and interpretation

    OpenAIRE

    Paul Regan

    2012-01-01

    Hans-Georg Gadamer’s philosophical hermeneutics is a popular qualitative research interpretive method aiming to explore the meaning of individual experiences in relation to understanding human interpretation. Gadamer identifies that authentic engagement with reading requires awareness of the inter-subjective nature of understanding in order to promote a reflective engagement with the text. The main concepts of Gadamer’s view of reading and understanding are explored in this paper in relation ...

  18. La Torre de Hanói y los Qn Grafos

    Directory of Open Access Journals (Sweden)

    Mª Milagros Latasa Asso

    2011-10-01

    Full Text Available La Torre de Hanói es uno de los hallazgos matemáticos más ingeniosos de la matemática recreativa. Gracias a una leyenda con tinte oriental hoy se conoce de modo universal. Se describen en este artículo las relaciones entre las soluciones del rompecabezas y los ciclos hamiltonianos en los grafos Qn.

  19. Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population

    OpenAIRE

    Zhao, Nan; Liu, Xin; Wang, Yongqin; Liu, Xiaoqiu; Li, Jiana; Yu, Litian; Ma, Liyuan; Wang, Shuyu; Zhang, Hongye; Liu, Lisheng; Zhao, Jingbo; Wang, Xingyu

    2012-01-01

    Abstract Background Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorphisms and their association with ischemic stroke in a Chinese Han population. Methods A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes...

  20. Zur Frage der Gewalt in Hubert Fichtes Interviews mit Hans Eppendorfen

    Directory of Open Access Journals (Sweden)

    Manfred Weinberg

    2000-11-01

    Full Text Available Este ensaio investiga a importância da violência na entrevista de Hubert Fichte com Hans Eppendorfer, o Homem de Couro - no plano conteudístico e no plano estrutural. Tenta-se demonstrar como Fichte manipula (violentamente o entrevistado. A violência que é tema da entrevista é examinada dentro do horizonte da teoria fichtiana do ritual.

  1. The first Koç Han: Pioneering modern architecture in Ankara

    Directory of Open Access Journals (Sweden)

    Oya Atalay Franck

    2013-01-01

    Full Text Available Koç Holding is the most established conglomerate in Turkey. Th e company’s beginnings date from the mid 1920s, when Ahmet Vehbi Koç, founder of Koç Holding, had his first own company registered with the Ankara Chamber of Commerce. In 1932, Koç moved his business from his father’s store on Anafartalar Street to a new building, the first Koç Han, erected the same year on Çankırı Street Nr.13 in Ulus. Th e building’s designer was Swiss-Austrian architect Ernst Arnold Egli, who had come to Turkey only five years earlier upon invitation by the government to work as chief architect of the Ministry of National Education. During his stay, which lasted from 1927 until 1940, Egli realized about 40 projects and worked on many more. Koç Han is the rare example of a commercial building by Egli. At a time when the urban aspect of the old town center of Ankara consisted mostly of one-or two-storeyed stone-and-wood houses, the first Koç Han represented an altogether new building type for the town, in being a multipurpose edifice with space for shops at street level, with large storage facilities below ground, and providing off ices and housing on the upper fl oors. Th e functional rigor of the plan and the sober modernism of the building’s facades contrasted strongly with the architecture of the time. In this respect, the first Koç Han was a strong statement regarding Ahmet Vehbi Koç’s belief in a modern Turkey and to the contribution of the building’s architect, Ernst Arnold Egli, to this project.

  2. Defect of focus in two-line resolution with Hanning amplitude filters

    Science.gov (United States)

    Karunasagar, D.; Bhikshamaiah, G.; Keshavulu Goud, M.; Lacha Goud, S.

    In the presence of defocusing the modified Sparrow limits of resolution for two-line objects have been investigated for a diffraction-limited coherent optical system apodized by generalized Hanning amplitude filters. These limits have been studied as a function of different parameters such as intensity ratio, the order of the filter for various amounts of apodization parameter. Results reveal that in some situations the defocusing is effective in enhancing the resolution of an optical system.

  3. RESOLUTION ENHANCEMENT ALGORITHM FOR SPACEBORN SAR BASED ON HANNING FUNCTION WEIGHTED SIDELOBE SUPPRESSION

    Directory of Open Access Journals (Sweden)

    C. Li

    2018-04-01

    Full Text Available Resolution and sidelobe are mutual restrict for SAR image. Usually sidelobe suppression is based on resolution reduction. This paper provide a method for resolution enchancement using sidelobe opposition speciality of hanning window and SAR image. The method can keep high resolution on the condition of sidelobe suppression. Compare to traditional method, this method can enchance 50 % resolution when sidelobe is −30dB.

  4. Environmental monitoring and radiation protection programs of Novi Han radioactive waste repository

    International Nuclear Information System (INIS)

    Christoskova, M.; Kostova, M.; Sheherov, L.; Bekiarov, P.; Iovtchev, M.

    2000-01-01

    The system for monitoring and control as an important part of the safety management of the Novi Han Radioactive Waste Repository contains two independent programs: environmental monitoring of the site (controlled area), the restricted access area and the surveillance area (supervised area) of the repository and radiation protection program including personal dosimetric control and indoor dosimetric control of workplaces in the buildings of the repository. The main activities related to the programs implementation are presented

  5. A large-scale survey of genetic copy number variations among Han Chinese residing in Taiwan

    Directory of Open Access Journals (Sweden)

    Wu Jer-Yuarn

    2008-12-01

    Full Text Available Abstract Background Copy number variations (CNVs have recently been recognized as important structural variations in the human genome. CNVs can affect gene expression and thus may contribute to phenotypic differences. The copy number inferring tool (CNIT is an effective hidden Markov model-based algorithm for estimating allele-specific copy number and predicting chromosomal alterations from single nucleotide polymorphism microarrays. The CNIT algorithm, which was constructed using data from 270 HapMap multi-ethnic individuals, was applied to identify CNVs from 300 unrelated Han Chinese individuals in Taiwan. Results Using stringent selection criteria, 230 regions with variable copy numbers were identified in the Han Chinese population; 133 (57.83% had been reported previously, 64 displayed greater than 1% CNV allele frequency. The average size of the CNV regions was 322 kb (ranging from 1.48 kb to 5.68 Mb and covered a total of 2.47% of the human genome. A total of 196 of the CNV regions were simple deletions and 27 were simple amplifications. There were 449 genes and 5 microRNAs within these CNV regions; some of these genes are known to be associated with diseases. Conclusion The identified CNVs are characteristic of the Han Chinese population and should be considered when genetic studies are conducted. The CNV distribution in the human genome is still poorly characterized, and there is much diversity among different ethnic populations.

  6. Association of rs662799 in APOA5 with CAD in Chinese Han population.

    Science.gov (United States)

    Chen, Hua; Ding, Shifang; Zhou, Mi; Wu, Xiayin; Liu, Xi; Wu, Yun; Liu, Dechao

    2018-01-08

    CAD (Coronary Artery Disease) is a complex disease that influenced by various environmental and genetic factors. Previous studies have found many single nucleotide polymorphisms (SNPs) associated with the risk of CAD occurrence. However, the results are inconsistent. In this study, we aim to investigate genetic etiology in Chinese Han population by analysis of 7 SNPs in lipid metabolism pathway that previously has been reported to be associated with CAD. A total of 631 samples were used in this study, including 435 CAD cases and 196 normal healthy controls. SNP genotyping were conducted via multiplex PCR amplifying followed by NGS (next-generation sequencing). Rs662799 in APOA5 (Apolipoprotein A5) gene was associated with CAD in Chinese Han population (Odds-ratio = 1.374, P-value = 0.03). No significant association was observed between the rest of SNPs and CAD. Stratified association analysis revealed rs5882 was associated with CAD in non-hypertension group (Odds-ratio = 1.593, P-value = 0.023). Rs1800588 was associated with CAD in smoking group (Odds-ratio = 1.603, P-value = 0.035). The minor allele of rs662799 was the risk factor of CAD occurrences in Chinese Han population.

  7. Genetic diversity of 21 autosomal STR loci in the Han population from Sichuan province, Southwest China.

    Science.gov (United States)

    He, Guanglin; Li, Ye; Wang, Zheng; Liang, Weibo; Luo, Haibo; Liao, Miao; Zhang, Ji; Yan, Jing; Li, Yingbi; Hou, Yiping; Wu, Jin

    2017-11-01

    Exploration of the ethnic origin and genetic differentiation of 56 Chinese officially recognized nationalities populations played a fundamental role in the research field of population genetics, forensic science, linguistics, anthropology, and archaeology. In the present study, population data of 21 autosomal STR loci (CSF1PO, D10S1248, D12S391, D13S317, D16S539, D18S51, D19S433, D21S11, D2S1338, D2S441, D3S1358, D5S818, D6S1043, D7S820, D8S1179, FGA, Penta D, Penta E, TH01, TPOX, and vWA) included in the AGCU EX22 kit in 2793 Southwest Han Chinese individuals was obtained and population genetic relationships among 28 Chinese populations were investigated. Our study indicated that the twenty-one autosomal STRs are highly polymorphic in the Sichuan Han population and can be used as a powerful tool in the routine forensic usage. MDS and phylogenetic analysis suggested that the Sichuan Han population kept a close genetic relationship with the southwest populations. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Prevalence of Dry Eye in Uyghur and Han Ethnic Groups in Western China.

    Science.gov (United States)

    Gong, Ying-Ying; Zhang, Fan; Zhou, Jin; Li, Jing; Zhang, Guang-Hui; Wang, Jun-Liang; Gu, Zhen-Sheng

    2017-06-01

    To describe and compare the prevalence and characteristics of dry eye among Han and Uyghur persons living in Kashi, the most inland city of China. A total of 1015 residents of Kashi participated in this 2013 cross-sectional study. To evaluate clinical characteristics, each subject completed (1) a dry-eye questionnaire detailing symptoms of dry eye, (2) Schirmer's I-test (SIT), (3) tear-film break-up time (BUT) test, and fluorescein staining of the cornea. Dry eye was defined as the existence of dry eye symptoms and at least two positive clinical signs. Data were analyzed using SPSS software. The prevalence and risk factors of dry eye were evaluated using a multivariate model. Overall, 282 (27.8%) of the 1015 participants were diagnosed with dry eye (95% confidence interval (CI): range, 25.5-30.1). The prevalence of dry eye among Han persons (37.9 %) (95% CI: range, 35.8-40.0) was higher than that among Uyghurs (21.8%) (95% CI: 19.6-24.0) (p dry eye was 25.6% (95% CI: range, 23.3-27.8) among men and 28.7% (95% CI: 26.5-30.9) among women (p > 0.05). Risk factors for dry eye included ethnicity, age, occupation, arthritis, and dry mouth. Our study revealed a higher prevalence of dry eye among Han than Uyghur persons in Kashi. Dry eye was significantly associated with environment and ethnicity.

  9. Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations.

    Science.gov (United States)

    Wang, Yuchen; Lu, Dongsheng; Chung, Yeun-Jun; Xu, Shuhua

    2018-01-01

    Han Chinese, Japanese and Korean, the three major ethnic groups of East Asia, share many similarities in appearance, language and culture etc., but their genetic relationships, divergence times and subsequent genetic exchanges have not been well studied. We conducted a genome-wide study and evaluated the population structure of 182 Han Chinese, 90 Japanese and 100 Korean individuals, together with the data of 630 individuals representing 8 populations wordwide. Our analyses revealed that Han Chinese, Japanese and Korean populations have distinct genetic makeup and can be well distinguished based on either the genome wide data or a panel of ancestry informative markers (AIMs). Their genetic structure corresponds well to their geographical distributions, indicating geographical isolation played a critical role in driving population differentiation in East Asia. The most recent common ancestor of the three populations was dated back to 3000 ~ 3600 years ago. Our analyses also revealed substantial admixture within the three populations which occurred subsequent to initial splits, and distinct gene introgression from surrounding populations, of which northern ancestral component is dominant. These estimations and findings facilitate to understanding population history and mechanism of human genetic diversity in East Asia, and have implications for both evolutionary and medical studies.

  10. Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China

    Directory of Open Access Journals (Sweden)

    Yingjie Dai

    2013-01-01

    Full Text Available Nitric oxide (NO is an important messenger molecule and effector molecule. This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS gene polymorphism with ischemic stroke in Han Chinese of North China. This was a case-control study. A total of 413 patients with ischemic stroke were recruited from Han Chinese of North China. There were 201 males and 212 females. In addition, 477 healthy subjects served as controls including 224 males and 253 females. Multiplex SNaPshot was employed to detect nNOS gene polymorphism (rs2293050, rs2139733, rs7308402, and rs1483757. Results showed that the rs1483757, rs2139733, and rs2293050 genotypes and allele frequencies were comparable between patients and controls. However, ischemic stroke patients had significantly reduced AG genotype and A allele frequency when compared with controls (P=0.037, P=0.041. After adjusting confounding factors (gender, age, smoking, history of drinking, hypertension, and diabetes, AG genotype and A allele were still related to ischemic stroke (OR=0.572, 95% CI: 0.335–0.978, P=0.041; OR=0.611, 95% C: 0.378–0.985, and P=0.041 and both were found to be protective factors. Our results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China.

  11. Replication study confirms link between TSPAN18 mutation and schizophrenia in Han Chinese.

    Directory of Open Access Journals (Sweden)

    Jianmin Yuan

    Full Text Available Schizophrenia (SCZ is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784 in the tetraspanins gene TSPAN18 as possible susceptibility loci for schizophrenia. Hoping to validate these findings, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls. Using the LDR-PCR method to genotype polymorphisms in TSPAN18, we found no significant differences (P>0.05 between patients and controls in either the allele or genotype frequency of the SNPs rs11038167 and rs11038172. We did find, however, that the frequency of the 'A' allele of SNP rs835784 is significantly higher in patients than in controls. We further observed a significant association (OR= 1.197, 95%CI= 1.047-1.369 between risk for SCZ and this 'A' allele. These results confirm the significant association, in Han Chinese populations, of increased SCZ risk and the variant of the TSPAN18 gene containing the 'A' allele of SNP rs835784.

  12. 汉魏石经杂考%Miscellaneous Research on Han and Wei Stone Classics

    Institute of Scientific and Technical Information of China (English)

    王东洋

    2017-01-01

    汉魏石经包括东汉熹平石经、《典论》石经和正始石经,三者均开刻于当时的京城洛阳,在中国文化史上具有重要意义。汉魏石经由朝廷下诏刊刻,立于太学,供天下儒生观瞻临摹。在纸质书写材料尚未普及的汉魏时期,汉魏石经起到了统一经学、保存文化、宣扬教化的作用。%Han and Wei Stone Classics with Xiping Stone classics,Dianlun Stone classics and Zhengshi Stone classics were carved in Luoyang City,has great significance in the history of Chinese culture.Under the royal order,Han and Wei Stone Classics were inscribed and erected in the Imperial College for the confucian scholars to learn and copy.In view of the underpopularization of paper writing material,Han and Wei Stone Classics played the role of unifying confucian classics,preserving culture and preaching and teaching.

  13. The chronological age estimation of third molar mineralization of Han population in southwestern China.

    Science.gov (United States)

    Qing, Maofeng; Qiu, Lihua; Gao, Zhi; Bhandari, Kishor

    2014-05-01

    The purpose of the study was to estimate the chronology of third molar mineralization in Han population of southwestern China and find its unique characteristics so that it would provide a reference in several legal cases like forensic age estimation. The study used Demirjian's staging method to study 2192 orthopantomograms of 984 male and 1208 female subjects aged between 8 and 25 years. The statistical data was analyzed by Student's t test and ANOVA. The conclusions of the study are: (1) The chronological mineralization age of third molars of Han population in Southwestern China is similar to the Turkish and the Japanese, was earlier than the Austrian and Han of South China, but later than the Spanish. (2) The mineralization timing of the third molars between two sides in maxilla or mandible has no significant differences in the same gender group. (3) There is no significant difference in mineralization of third molars between male and female, except for tooth 48 in Demirjian's stage E. (4) The mineralization of third molar in maxilla is earlier than mandible. Copyright © 2014 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  14. Runoff and Sediment Response to Cascade Hydropower Exploitation in the Middle and Lower Han River, China

    Directory of Open Access Journals (Sweden)

    Junhong Zhang

    2017-01-01

    Full Text Available With the rapid development of hydropower exploitation in China, changes in runoff and sediment transport have become a significant issue that cannot be neglected. In this study, the Han River was selected as a study case, where the runoff variation and changes in sediment load at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations were analyzed in different time periods. The results indicate that impact of cascade hydropower exploitation on runoff and sediment transport is significantly different even during the same time periods. After reservoir regulation, the decreasing of sediment load is faster than that of runoff. Strong positive correlation between runoff and sediment load exists during different time periods, while reservoir operation leads to different turning points at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations in the middle and lower Han River. As a key driving factor, runoff variation contributed to sediment transport with different impact index CR. The impact index CR before and after the first change point at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations is 43.35%, −3.68%, 11.17%, and 30.12%, respectively. This study helps us understand and evaluate the hydrological changes under cascade hydropower exploitation in the middle and lower Han River.

  15. Compound heterozygous MYO7A mutations segregating Usher syndrome type 2 in a Han family.

    Science.gov (United States)

    Zong, Ling; Chen, Kaitian; Wu, Xuan; Liu, Min; Jiang, Hongyan

    2016-11-01

    Identification of rare deafness genes for inherited congenital sensorineural hearing impairment remains difficult, because a large variety of genes are implicated. In this study we applied targeted capture and next-generation sequencing to uncover the underlying gene in a three-generation Han family segregating recessive inherited hearing loss and retinitis pigmentosa. After excluding mutations in common deafness genes GJB2, SLC26A4 and the mitochondrial gene, genomic DNA of the proband of a Han family was subjected to targeted next-generation sequencing. The candidate mutations were confirmed by Sanger sequencing and subsequently analyzed with in silico tools. An unreported splice site mutation c.3924+1G > C compound with c.6028G > A in the MYO7A gene were detected to cosegregate with the phenotype in this pedigree. Both mutations, located in the evolutionarily conserved FERM domain in myosin VIIA, were predicted to be pathogenic. In this family, profound sensorineural hearing impairment and retinitis pigmentosa without vestibular disorder, constituted the typical Usher syndrome type 2. Identification of novel mutation in compound heterozygosity in MYO7A gene revealed the genetic origin of Usher syndrome type 2 in this Han family. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  16. Multiple genetic variants associated with primary biliary cirrhosis in a Han Chinese population.

    Science.gov (United States)

    Dong, Ming; Li, Jinxin; Tang, Ruqi; Zhu, Ping; Qiu, Fang; Wang, Chan; Qiu, Jie; Wang, Lan; Dai, Yaping; Xu, Ping; Gao, Yueqiu; Han, Chongxu; Wang, Yongzhong; Wu, Jian; Wu, Xudong; Zhang, Kui; Dai, Na; Sun, Weihao; Zhou, Jianpo; Hu, Zhigang; Liu, Lei; Jiang, Yuzhang; Nie, Jinshan; Zhao, Yi; Gong, Yuhua; Tian, Ye; Ji, Hualiang; Jiao, Zhijun; Jiang, Po; Shi, Xingjuan; Jawed, Rohil; Zhang, Yu; Huang, Qinghai; Li, Enling; Wei, Yiran; Xie, Wei; Zhao, Weifeng; Liu, Xiang; Zhu, Xiang; Qiu, Hong; He, Gengsheng; Chen, Weichang; Seldin, Michael F; Gershwin, M Eric; Liu, Xiangdong; Ma, Xiong

    2015-06-01

    Multiple genome-wide association studies of primary biliary cirrhosis (PBC) in both European and Japanese ancestries have shown significant associations of many genetic loci contributing to the susceptibility to PBC. Major differences in susceptibility loci between these two population groups were observed. In this study, we examined whether the most significant loci observed in either European and/or Japanese cohorts are associated with PBC in a Han Chinese population. In 1070 PBC patients and 1198 controls, we observed highly significant associations at CD80 (rs2293370, P = 2.67 × 10(-8)) and TNFSF15 (rs4979462, P = 3.86 × 10(-8)) and significant associations at 17q12-21 (rs9303277), PDGFB (rs715505), NF-κB1 (rs7665090), IL12RB2 (rs11209050), and STAT4 (rs7574865; all corrected P values rs7574865) was strongly associated after additional control samples were analyzed. Our study is the first large-scale genetic analysis in a Han Chinese PBC cohort. These results do not only reflect that Han Chinese PBC patients share common genetic susceptibility genes with both their Japanese and European counterparts but also suggest a distinctly different genetic susceptibility profile.

  17. γ-decay of {}_{8}^{16}{{\\rm{O}}}_{8}\\,{and}\\,{}_{7}^{16}{{\\rm{N}}}_{9} in proton-neutron Tamm-Dancoff and random phase approximations with optimized surface δ interaction

    Science.gov (United States)

    Pahlavani, M. R.; Firoozi, B.

    2016-09-01

    γ-ray transitions from excited states of {}16{{N}} and {}16{{O}} isomers that appear in the γ spectrum of the {}616{{{C}}}10\\to {}716{{{N}}}9\\to {}816{{{O}}}8 beta decay chain are investigated. The theoretical approach used in this research starts with a mean-field potential consisting of a phenomenological Woods-Saxon potential including spin-orbit and Coulomb terms (for protons) in order to obtain single-particle energies and wave functions for nucleons in a nucleus. A schematic residual surface delta interaction is then employed on the top of the mean field and is treated within the proton-neutron Tamm-Dancoff approximation (pnTDA) and the proton-neutron random phase approximation. The goal is to use an optimized surface delta interaction interaction, as a residual interaction, to improve the results. We have used artificial intelligence algorithms to establish a good agreement between theoretical and experimental energy spectra. The final results of the ‘optimized’ calculations are reasonable via this approach.

  18. Homeopathic potencies of Arnica montana L. change gene expression in a Tamm-Horsfall protein-1 cell line in vitro model: the role of ethanol as a possible confounder and statistical bias.

    Science.gov (United States)

    Chirumbolo, Salvatore; Bjørklund, Geir

    2017-07-01

    Marzotto et al. showed that homeopathic preparations of Arnica montana L. acted directly on gene expression of Tamm-Horsfall protein-1 (THP-1) monocyte/macrophage cell lines activated with phorbol12-myristate13-acetate and interleukin-4 (IL-4). A. montana homeopathic dilutions are used in complementary and alternative medicine to treat inflammation disorders and post-traumatic events as well as for wound repair. The French Pharmacopoeia of these remedies uses 0.3% ethanol in each centesimal dilution. In this paper, we discuss how ethanol-containing A. montana homeopathic centesimal dilutions can change gene expression in IL-4-treated monocyte/macrophage THP-1. We assessed the role of ethanol in the Arnica homeopathic dilutions containing this alcohol by investigating its action on gene expression of THP-1 cell. Evidence would strongly suggest that the presence of ethanol in these remedies might play a fundamental role in the dilutions ability to affect gene expression, particularly for doses from 5c to 15c. Where, rather than playing a major role in the mesoscopic structure of water, the ethanol might have a chemical-physical role in the induction of THP-1 gene expression, apoptosis, and deoxyribonucleic acid function. This evidence generates a debate about the suggestion that the use of a binary-mixed solvent in homeopathic chemistry, used by Hahnemann since 1810, may be fundamental to explain the activity of homeopathy on cell models.

  19. The effect of basis set and exchange-correlation functional on time-dependent density functional theory calculations within the Tamm-Dancoff approximation of the x-ray emission spectroscopy of transition metal complexes.

    Science.gov (United States)

    Roper, Ian P E; Besley, Nicholas A

    2016-03-21

    The simulation of X-ray emission spectra of transition metal complexes with time-dependent density functional theory (TDDFT) is investigated. X-ray emission spectra can be computed within TDDFT in conjunction with the Tamm-Dancoff approximation by using a reference determinant with a vacancy in the relevant core orbital, and these calculations can be performed using the frozen orbital approximation or with the relaxation of the orbitals of the intermediate core-ionised state included. Both standard exchange-correlation functionals and functionals specifically designed for X-ray emission spectroscopy are studied, and it is shown that the computed spectral band profiles are sensitive to the exchange-correlation functional used. The computed intensities of the spectral bands can be rationalised by considering the metal p orbital character of the valence molecular orbitals. To compute X-ray emission spectra with the correct energy scale allowing a direct comparison with experiment requires the relaxation of the core-ionised state to be included and the use of specifically designed functionals with increased amounts of Hartree-Fock exchange in conjunction with high quality basis sets. A range-corrected functional with increased Hartree-Fock exchange in the short range provides transition energies close to experiment and spectral band profiles that have a similar accuracy to those from standard functionals.

  20. Association of Interleukin-1 Gene Single Nucleotide Polymorphisms with Keratoconus in Chinese Han Population.

    Science.gov (United States)

    Wang, Yani; Wei, Wei; Zhang, Changning; Zhang, XueHui; Liu, Ming; Zhu, Xiuping; Xu, Kun

    2016-05-01

    To investigate whether interleukin-1 alpha (IL1A) and interleukin-1 beta (IL1B) polymorphisms are associated with keratoconus (KC) in unrelated Chinese Han patients. The IL1A (rs2071376) and IL1B (rs1143627, rs16944) polymorphisms were genotyped in 115 unrelated Chinese Han KC patients and 101 healthy Chinese Han volunteers with the Sequenom MassARRAY RS1000. Sequenom Typer 4.0 software, PLINK 1.07, Haploview 4.0 software platform were used to analyze the allelic variants of IL1A and IL1B genes, and their association with KC risk factors were assessed. Among the variants, the three SNPs (rs2071376 in IL1A, rs1143627 and rs16944 in the promoter region of IL1B) were different between the two groups. The A allele of rs2071376 (A > C, p = 0.017, OR = 1.968, 95% C.I. 1.313-3.425), the C allele of rs1143627 (C > T, p rs16944 (A > G, p = 0.002, OR = 2.401, 95% C.I. 1.396-4.161) were associated with a increased risk of KC in Chinese Han patients. This study showed that rs2071376, rs1143627 and rs16944 had significant differences in associations between KC patients and the control group when different genotypes were analyzed in three models (dominant, recessive, and additive). In the haplotype analysis, the two single nucleotide polymorphisms (SNPs), rs1143627 and rs16944 showed strong linkage disequilibrium. In addition, Haplotype "ACA" was found to be associated with a higher risk of developing KC (OR = 12.91, p < 0.001). Keratocyte apoptosis is an initiating event in the pathogenesis of KC which could be induced by the altered levels of IL1 gene. These findings confirmed that polymorphisms in IL1 genes were associated with risk of KC in the Chinese Han population, which help us to gain insight into the pathogenesis of KC.

  1. Population data of 17 short tandem repeat loci in 2923 individuals from the Han population of Nantong in East China.

    Science.gov (United States)

    Yang, Min; Li, Liming; Han, Haijun; Jin, Li; Jia, Dongtao; Li, Shilin

    2016-09-01

    Nantong is located in mid-eastern China, and the Han population in Nantong may be greatly affected by population admixture between northern and southern Han Chinese populations. In this study, we analyzed 17 autosomal short tandem repeat (STR) loci on 2923 unrelated individuals collected from the Han population of Nantong. No significant deviation from Hardy-Weinberg equilibrium was observed at all STR loci, and the expected heterozygosity ranged from 0.6184 to 0.9187. The combined match probability (CMP) was 3.87 × 10(-21), and the combined power of discrimination (CPD) was 99.999999999999999999613 %. No significant difference of allele frequencies was observed between Nantong and other Han populations at all STR loci, as well as Dai, Mongolian, and Tibetan. Significant differences were only observed between Nantong Han and Uyghur at TH01, as well as Nantong Han and Dong at CSF1PO and FGA. Nantong Han showed significant differences between She, Bouyei, and Miao at multiple STR loci.

  2. Genetic Variation of 25 Y-Chromosomal and 15 Autosomal STR Loci in the Han Chinese Population of Liaoning Province, Northeast China.

    Science.gov (United States)

    Yao, Jun; Wang, Bao-Jie

    2016-01-01

    In the present study, we investigated the genetic characteristics of 25 Y-chromosomal and 15 autosomal short tandem repeat (STR) loci in 305 unrelated Han Chinese male individuals from Liaoning Province using AmpFISTR® Yfiler® Plus and IdentifilerTM PCR amplification kits. Population comparison was performed between Liaoning Han population and different ethnic groups to better understand the genetic background of the Liaoning Han population. For Y-STR loci, the overall haplotype diversity was 0.9997 and the discrimination capacity was 0.9607. Gene diversity values ranged from 0.4525 (DYS391) to 0.9617 (DYS385). Rst and two multi-dimensional scaling plots showed that minor differences were observed when the Liaoning Han population was compared to the Jilin Han Chinese, Beijing Han Chinese, Liaoning Manchu, Liaoning Mongolian, Liaoning Xibe, Shandong Han Chinese, Jiangsu Han Chinese, Anhui Han Chinese, Guizhou Han Chinese and Liaoning Hui populations; by contrast, major differences were observed when the Shanxi Han Chinese, Yunnan Bai, Jiangxi Han Chinese, Guangdong Han Chinese, Liaoning Korean, Hunan Tujia, Guangxi Zhuang, Gansu Tibetan, Xishuangbanna Dai, South Korean, Japanese and Hunan Miao populations. For autosomal STR loci, DP ranged from 0.9621 (D2S1338) to 0.8177 (TPOX), with PE distributing from 0.7521 (D18S51) to 0.2988 (TH01). A population comparison was performed and no statistically significant differences were detected at any STR loci between Liaoning Han, China Dong, and Shaanxi Han populations. The results showed that the 25 Y-STR and 15 autosomal STR loci in the Liaoning Han population were valuable for forensic applications and human genetics, and Liaoning Han was an independent endogenous ethnicity with a unique subpopulation structure.

  3. Genetic Variation of 25 Y-Chromosomal and 15 Autosomal STR Loci in the Han Chinese Population of Liaoning Province, Northeast China.

    Directory of Open Access Journals (Sweden)

    Jun Yao

    Full Text Available In the present study, we investigated the genetic characteristics of 25 Y-chromosomal and 15 autosomal short tandem repeat (STR loci in 305 unrelated Han Chinese male individuals from Liaoning Province using AmpFISTR® Yfiler® Plus and IdentifilerTM PCR amplification kits. Population comparison was performed between Liaoning Han population and different ethnic groups to better understand the genetic background of the Liaoning Han population. For Y-STR loci, the overall haplotype diversity was 0.9997 and the discrimination capacity was 0.9607. Gene diversity values ranged from 0.4525 (DYS391 to 0.9617 (DYS385. Rst and two multi-dimensional scaling plots showed that minor differences were observed when the Liaoning Han population was compared to the Jilin Han Chinese, Beijing Han Chinese, Liaoning Manchu, Liaoning Mongolian, Liaoning Xibe, Shandong Han Chinese, Jiangsu Han Chinese, Anhui Han Chinese, Guizhou Han Chinese and Liaoning Hui populations; by contrast, major differences were observed when the Shanxi Han Chinese, Yunnan Bai, Jiangxi Han Chinese, Guangdong Han Chinese, Liaoning Korean, Hunan Tujia, Guangxi Zhuang, Gansu Tibetan, Xishuangbanna Dai, South Korean, Japanese and Hunan Miao populations. For autosomal STR loci, DP ranged from 0.9621 (D2S1338 to 0.8177 (TPOX, with PE distributing from 0.7521 (D18S51 to 0.2988 (TH01. A population comparison was performed and no statistically significant differences were detected at any STR loci between Liaoning Han, China Dong, and Shaanxi Han populations. The results showed that the 25 Y-STR and 15 autosomal STR loci in the Liaoning Han population were valuable for forensic applications and human genetics, and Liaoning Han was an independent endogenous ethnicity with a unique subpopulation structure.

  4. Quines empreses han aguantat millor la crisi, les empreses familiars o les no familiars?

    Directory of Open Access Journals (Sweden)

    Jose Luis Gallizo

    2014-12-01

    Full Text Available Objecte: En aquest estudi és porta a terme un anàlisi comparatiu sobre l’evolució de l’estructura econòmica i financera que presenten les empreses familiars i no familiars de Catalunya en un context d’intensa crisi econòmica. La seva finalitat és poder donar resposta a dos qüestions principals: identificar les característiques diferencials de l’EF respecte a l’EnF i comprovar si aquestes característiques diferencials han permès a les EF aguantar millor la crisi econòmica. Disseny/metodologia: S’ha analitzat una mostra de 750 grans i mitjanes empreses de Catalunya (550 familiars i 200 no familiars durant el període 2008-2012. Les dades s’han obtingut a través de la base de dades SABI, i per a la classificació de les empreses en familiars i no familiars s’ha dut a terme una comprovació individual de cadascuna d’elles per evitar habituals errors de classificació. Posteriorment les empreses s’han classificat en funció de la seva dimensió per dotar d’una major robustes els resultats. També s’ha procurat que la distribució d’empreses per sectors fos similar en les diferents categories per evitar que un efecte sectorial pogués tergiversar els resultats de l’estudi. Aportacions i resultats: L’estudi ha permès constatar les hipòtesis establertes sobre el finançament de les empreses familiars i concloure que aquestes presenten una estructura financera diferent a les Empreses no familiars. Les empreses familiars als seus balanços, presenten un major nivell d’autofinançament gràcies a la seva menor distribució de dividends. A més a més, les EF presenten millors resultats en quant a nivells de cobertura i liquiditat, ja que es troben més capitalitzades i presenten uns nivells d’endeutament inferior que les Empreses no familiars. Aquestes característiques patrimonials i financeres han contribuït a que les empreses familiars aguantin millor els anys de crisi, produint-se durant aquests anys

  5. Novi Han Radioactive Waste Repository post-closure safety assessment, ver.2

    International Nuclear Information System (INIS)

    Mateeva, M.

    2003-01-01

    The methodology for the post-closure safety assessment is presented. The assessment context includes regulatory framework (protection principles); scope and time frame; radiological and technical requirements; modeling etc. The description of the Novi Han disposal system contains site location. meteorological, hydrological and seismological characteristics; waste and repository description and human activities characteristics. The next step in the methodology is scenario development and justification. The systematic generation os exposure scenarios is considered as central to the post-closure safety assessment. The most important requirements for the systematic scenario generation approach are: transparency, comprehensiveness (all possible FEPs influencing the the disposal system and the radionuclide release should be considered); relevant future evolutions; identification of critical issues and investigation of the robustness of the system. For the source-pathway-receptor analysis the Process System is divided into near-field, geosphere/atmosphere and biosphere, describing the key facets controlling the potential radionuclide migration to the environment. The schematic division of the Novi Han near-field Process System into lower-level conceptual features is presented and discussed. As a result of the examinations of the FEPs three classes of scenarios are identified for the Novi Han post-closure safety assessment: Environmental evolution scenarios (geological change and climate change); future human action scenarios (human intrusion and archaeological action); Scenarios with very low probability (terrorism, crashes, explosions). The safety assessment iteration leads to identification of a modern scenario generation approach, assessment of key radionuclide releases, geological and hydrological evaluation, identification of the key parameters from sensitivity analysis etc. Examples of conceptual models are given. For the mathematical modeling the AMBER code is used

  6. Earthquakes as collapse precursors at the Han-sur-Lesse Cave in the Belgian Ardennes

    Science.gov (United States)

    Camelbeeck, Thierry; Quinif, Yves; Verheyden, Sophie; Vanneste, Kris; Knuts, Elisabeth

    2018-05-01

    Collapse activation is an ongoing process in the evolution of karstic networks related to the weakening of cave vaults. Because collapses are infrequent, few have been directly observed, making it challenging to evaluate the role of external processes in their initiation and triggering. Here, we study the two most recent collapses in the Dôme chamber of the Han-sur-Lesse Cave (Belgian Ardenne) that occurred on or shortly after 3rd December 1828 and between the 13th and 14th of March 1984. Because of the low probability that the two earthquakes that generated the strongest ground motions in Han-sur-Lesse since 1800, on 23rd February 1828 (Mw = 5.1 in Central Belgium) and 8th November 1983 (Mw = 4.8 in Liège) occurred by coincidence less than one year before these collapses, we suggest that the collapses are related to these earthquakes. We argue that the earthquakes accelerated the cave vault instability, leading to the collapses by the action of other factors weakening the host rock. In particular, the 1828 collapse was likely triggered by a smaller Mw = 4.2 nearby earthquake. The 1984 collapse followed two months of heavy rainfall that would have increased water infiltration and pressure in the rock mass favoring destabilization of the cave ceiling. Lamina counting of a stalagmite growing on the 1828 debris dates the collapse at 1826 ± 9 CE, demonstrating the possibility of dating previous collapses with a few years of uncertainty. Furthermore, our study opens new perspectives for studying collapses and their chronology both in the Han-sur-Lesse Cave and in other karstic networks. We suggest that earthquake activity could play a stronger role than previously thought in initiating cave collapses.

  7. The Dynamic Distribution of Small-Tail Han Sheep Microbiota across Different Intestinal Segments

    Directory of Open Access Journals (Sweden)

    Hao Zhang

    2018-01-01

    Full Text Available The sheep intestinal tract is characterized by a diverse microbial ecosystem that is vital for the host to digest diet material. The importance of gut microbiota (GM of animals has also been widely acknowledged because of its pivotal roles in the health and well-being of animals. However, there are no relevant studies on GM of small-tail Han sheep, a superior mutton variety domestic in China. In this study, the structure and distribution of gut microflora were studied by high-throughput sequencing technology. Results showed a significant difference between jejunum and cecum, jejunum, and rectum. Meanwhile, the cecum and rectum not only display higher species richness but also exhibit higher similarity of the bacterial diversity than that of the jejunum based on the results of abundance-based coverage estimator (ACE, Chao1, and Shannon indexes. Firmicutes and Bacteroidetes were the predominant phyla in cecum and rectum, while higher relative abundances of Firmicutes and Cyanobacteria were observed in jejunum. At the genus level, Bacteroidetes, Ruminococcus, Lactobacillus, Flavonifractor, and Clostridium were the dominant genera in the cecum and rectum. An obvious dynamic distribution of Lactobacillus is continuously decreasing from the jejunum to the cecum, then to the rectum, whereas the result of Bacteroides is completely inverse. In addition, this study also found many kinds of bacteria associated with the production of volatile fatty acids (VFA colonized in the large intestine. This study is the first to investigate the distribution of intestinal flora in small-tail Han sheep. The findings provide an important indication for diagnosis and treatment of intestinal diseases in small-tail Han sheep, as well as offer a direction for the development of intestinal microecological preparations.

  8. FCRL3 gene polymorphisms confer autoimmunity risk for allergic rhinitis in a Chinese Han population.

    Directory of Open Access Journals (Sweden)

    Zheng Gu

    Full Text Available Heredity and environmental exposures may contribute to a predisposition to allergic rhinitis (AR. Autoimmunity may also involve into this pathologic process. FCRL3 (Fc receptor-like 3 gene, a novel immunoregulatory gene, has recently been reported to play a role in autoimmune diseases.This study was performed to evaluate the potential association of FCRL3 polymorphisms with AR in a Chinese Han population.Five single-nucleotide polymorphisms of FCRL3, rs945635, rs3761959, rs7522061, rs10489678 and rs7528684 were genotyped in 540 AR patients and 600 healthy controls using a PCR-restriction fragment length polymorphism assay. Allele, genotype and haplotype frequencies were compared between patients and controls using the χ2 test. The online software platform SHEsis was used to analyze their haplotypes.This study identified three strong risk SNPs rs7528684, rs10489678, rs7522061 and one weak risk SNP rs945635 of FCRL3 in Chinese Han AR patients. For rs7528684, a significantly increased prevalence of the AA genotype and A allele in AR patients was recorded. The frequency of the GG genotype and G allele of rs10489678 was markedly higher in AR patients than those in controls. For rs7522061, a higher frequency of the TT genotype, and a lower frequency of the CT genotype were found in AR patients. Concerning rs945635, a lower frequency of the CC genotype, and a higher frequency of G allele were observed in AR patients. According to the analysis of the three strong positive SNPs, the haplotype of AGT increased significantly in AR cases (AR = 38.8%, Controls = 24.3%, P = 8.29 × 10(-14, OR [95% CI] 1.978 [1.652~2.368].This study found a significant association between the SNPs in FCRL3 gene and AR in Chinese Han patients. The results suggest these gene polymorphisms might be the autoimmunity risk for AR.

  9. Environmental Risk Factors in Han and Uyghur Children with Dyslexia: A Comparative Study.

    Science.gov (United States)

    Zhao, Hua; Zhang, Baoping; Chen, Yun; Zhou, Xiang; Zuo, Pengxiang

    2016-01-01

    Several studies have been conducted to explore risk factors for dyslexia. However, most studies examining dyslexia have been skewed toward Western countries, and few have considered two nationalities simultaneously. This study focused on differences in dyslexia prevalence and potential environmental risk factors between Han and Uyghur children. A cross-sectional study was conducted in Kashgar and Aksu, cities in Xinjiang province, China. A two-stage sampling strategy was used to recruit 2,854 students in grades 3-6 from 5 primary schools in 5 districts; 2,348 valid student questionnaires were included in the analysis. Dyslexia checklists for Chinese and Uyghur children and pupil rating scales were used to identify children with dyslexia. Questions related to the home literacy environment and reading ability were used to evaluate potential environmental risk factors. Single factor analysis and multivariate logistic regression were used to examine prevalence and risk factors for dyslexia. Dyslexia prevalence differed significantly between Han (3.9%) and Uyghur (7.0%) children (P dyslexia prevalence between Han and Uyghur children could have occurred because of factors such as mother's occupation (P = 0.02, OR = 0.04, 95% CI = 0.01-0.68) and the frequency with which parents told stories (P = 0.00, OR = 4.50, 95% CI = 1.67-12.11). The prevalence of dyslexia was high in all children, particularly those in the Uyghur group. Environmental factors could have been responsible for some of the differences observed. The results contribute to the early identification and management of dyslexia in children from these two groups and research examining developmental dyslexia and differences in racial genetics.

  10. Environmental Risk Factors in Han and Uyghur Children with Dyslexia: A Comparative Study.

    Directory of Open Access Journals (Sweden)

    Hua Zhao

    Full Text Available Several studies have been conducted to explore risk factors for dyslexia. However, most studies examining dyslexia have been skewed toward Western countries, and few have considered two nationalities simultaneously. This study focused on differences in dyslexia prevalence and potential environmental risk factors between Han and Uyghur children.A cross-sectional study was conducted in Kashgar and Aksu, cities in Xinjiang province, China. A two-stage sampling strategy was used to recruit 2,854 students in grades 3-6 from 5 primary schools in 5 districts; 2,348 valid student questionnaires were included in the analysis. Dyslexia checklists for Chinese and Uyghur children and pupil rating scales were used to identify children with dyslexia. Questions related to the home literacy environment and reading ability were used to evaluate potential environmental risk factors. Single factor analysis and multivariate logistic regression were used to examine prevalence and risk factors for dyslexia.Dyslexia prevalence differed significantly between Han (3.9% and Uyghur (7.0% children (P < 0.05, and the boy-to-girl diagnosis ratio was almost 2:1. Multiple logistic regression analysis showed that ethnic differences in dyslexia prevalence between Han and Uyghur children could have occurred because of factors such as mother's occupation (P = 0.02, OR = 0.04, 95% CI = 0.01-0.68 and the frequency with which parents told stories (P = 0.00, OR = 4.50, 95% CI = 1.67-12.11.The prevalence of dyslexia was high in all children, particularly those in the Uyghur group. Environmental factors could have been responsible for some of the differences observed. The results contribute to the early identification and management of dyslexia in children from these two groups and research examining developmental dyslexia and differences in racial genetics.

  11. La discreta y sorprendente vigencia del ideólogo del despotismo chino: Han Feizi

    Directory of Open Access Journals (Sweden)

    Conde, Juan Luis

    2016-06-01

    Full Text Available Han Feizi (3rd century B.C. is the main representative of the Chinese Legalist school (făjiā. The tenets of this political theory have earned him the nickname “the Chinese Machiavelli”. His ideas were adopted by Qin Shihuang, the so-called First Emperor, who unified China and unleashed a despotic régime characterized by the crackdown of any political debate and the suppression of free speech. The connexion between rhetorical development and the political sphere in the context of Classical China’s last stage may set the scene for a wider discussion about that link. Comparative rhetoric will provide further ground for connexions between classical Chinese Legalist ideas and contemporary Neoliberal discourse.Han Feizi (s. III a.C. es el principal representante de la escuela legista china (făjiā. Los principios de su teoría política le han granjeado el apodo de “el Maquiavelo chino”. Sus ideas serían adoptadas por Qin Shihuang, el Primer Emperador, quien unificó China e impuso un régimen despótico caracterizado por la represión del debate político y la supresión de la libertad de expresión. La conexión entre el desarrollo de la retórica y la situación política en el contexto de la última etapa del clasicismo chino puede servir de fondo para una consideración más amplia de dicho nexo. La retórica comparada proporciona las bases para relacionar el pensamiento legista chino con el discurso neoliberal contemporáneo.

  12. Genotype-phenotype correlation of xeroderma pigmentosum in a Chinese Han population.

    Science.gov (United States)

    Sun, Z; Zhang, J; Guo, Y; Ni, C; Liang, J; Cheng, R; Li, M; Yao, Z

    2015-04-01

    Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by extreme sensitivity to sunlight, freckle-like pigmentation and a greatly increased incidence of skin cancers. Genetic mutation detection and genotype-phenotype analysis of XP are rarely reported in the Chinese Han population. To investigate the mutational spectrum of XP in a Chinese Han population, to discover any genotype-phenotype correlation and, consequently, to propose a simple and effective tool for the molecular diagnosis of XP. This study was carried out on 12 unrelated Chinese families that included 13 patients with clinically suspected XP. Genomic DNA was extracted from peripheral blood samples. Mutation screening was performed by direct sequencing of exons and flanking intron-exon boundaries for the entire coding region of eight XP genes. In 12 patients, direct sequencing of the whole coding region of eight XP genes revealed pathogenic mutations, including seven compound heterozygous mutations, three homozygous mutations and a Japanese founder mutation. Thirteen mutations have not been previously identified. This cohort was composed of four patients with XP-C (XPC), two with XP-G (ERCC5), three with XP-A (XPA) and three with XP-V (POLH). This study identified 13 novel mutations and extended the mutation spectrum of XP in the Chinese Han population. In this cohort, we found that patients with XP-G have no neurological symptoms, and patients with XP-A and XP-V have a high incidence of malignancy. Furthermore, lack of stringent protection against sunlight, late diagnosis and long duration of disease play an important role. © 2014 British Association of Dermatologists.

  13. Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population.

    Science.gov (United States)

    Su, Yin; Zhao, Yi; Liu, Xu; Guo, Jian-Ping; Jiang, Quan; Liu, Xiang-Yuan; Zhang, Feng-Chun; Zheng, Yi; Li, Xiao-Xia; Song, Hui; Huang, Ci-Bo; Huang, Yan-Hong; Wang, Tian; Pan, Si-Si; Li, Chun; Liu, Xia; Zhu, Lei; Zhang, Chun-Fang; Li, Zhan-Guo

    2010-11-01

    Recent studies have identified signal transducer and activator of transcription 4 (STAT4) as a susceptibility gene for systemic lupus erythematosus (SLE) in different populations. In order to examine whether the allele distribution of the single nucleotide polymorphism (SNP) in gene STAT4 rs7574865 in patients with SLE is different from those of healthy controls in Chinese Northern Han population, we investigated whether the variants of STAT4 rs7574865 were associated with any specific clinical features of SLE. We genotyped SNPs in STAT4 rs7574865 in 252 patients with SLE and 497 healthy controls. All subjects were from the Northern part of Chinese Han population. The genotypes in rs7574865 were determined by polymerase chain reaction (PCR) and consequence direct sequencing of PCR products in the DNA samples. There was a significant difference in distribution of the SNPs in rs7574865 between the SLE patients and healthy controls. Compared with healthy controls, there was a significant correlation between TT genotypes in rs7574865 and the risk of SLE when GG genotype was used as a reference genotype after adjusting for gender and age. The frequency of T allele in the SLE patients was strongly significantly higher than that of healthy controls. Furthermore, there was a significant difference in the distribution of SNP in rs7574865 between male and female SLE patients, when compared with healthy controls. The frequency of T allele in rs7574865 in male patients was significantly higher than that of male healthy controls or female patients. There was no significant correlation between the frequencies of T allele in STAT4 rs7574865 and the clinical features of SLE. The SNP rs7574865 in STAT4 is strongly associated with risk of SLE in the Chinese Northern Han population. The TT genotype and T allele in STAT4 rs7574869 are susceptibility factors for SLE, especially for male SLE patients.

  14. His Excellency Dr. Hans Brattskar, Ambassador and Permanent Representative of Norway to the United Nations Office, visiting CERN

    CERN Multimedia

    AUTHOR|(CDS)2099575

    2016-01-01

    Ambassador Hans Brattskar signing the guest book with Director for international relations Charlotte Warakaulle and Director-General Fabiola Gianotti; Deputy Permanent Representative and Minister Kjersti Sommerset and CERN Advisers Pippa Wells and Jens Vigen are also present.

  15. Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population

    OpenAIRE

    Tsai, Ming-Kai; Wang, Hui-Min David; Shiang, Jeng-Chuan; Chen, I-Hung; Wang, Chih-Chiang; Shiao, Ya-Fen; Liu, Wen-Sheng; Lin, Tai-Jung; Chen, Tsung-Ming; Chen, Ya-Huey

    2014-01-01

    Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan's Chinese Han population, with our retrospective case-control study genotyping ...

  16. Gardens and Gateways: Journeys within the Vision of Han-shan

    Directory of Open Access Journals (Sweden)

    Anne Beidler

    2011-04-01

    Full Text Available Although rooted in the work of the T’ang poet Han-shan, this paper is ultimately about the ways in which writers and artists engage with what they experience in the world. The work of filmmaker Trin T Minh-Ha, poems by W.S. Merwin, Burtin Watson’s translations, and the thoughts on the creative process of translation by Tony Barnstone and Gary Snyder have all informed my work as an artist and the images I present here.

  17. Shaping biomedical objects across history and philosophy:a conversation with Hans-Jörg Rheinberger.

    Science.gov (United States)

    García-Sancho, Miguel; González-Silva, Matiana; Jesús Santesmases, María; Rheinberger, Hans-Jörg

    2014-01-01

    Historical epistemology, according to the historian of science Hans-Jörg Rheinberger, is a space through which "to take experimental laboratory work into the realm of philosophy". This key concept, together with the crucial events and challenges of his career, were discussed in a public conversation which took place on the occasion of Rheinberger's retirement. By making sense of natural phenomena in the laboratory, the act of experimenting shapes the object; it is this shaping which became the core of Rheinberger's own research across biology and philosophy into history. For his intellectual agenda, a history of the life sciences so constructed became "epistemologically demanding".

  18. Hans Joas & Daniel R. Huebner (eds.), The Timeliness of George Herbert Mead

    OpenAIRE

    Baggio, Guido

    2018-01-01

    The Timeliness of George Herbert Mead is a significant contribution to the recent “Mead renaissance.” It gathers some contributions first presented at the conference celebrating the 150th anniversary of the birth of George Herbert Mead held in April 2013 at the University of Chicago and organized by Hans Joas, Andrew Abbott, Daniel Huebner, and Christopher Takacs. The volume brings scholarship on G. H. Mead up to date highlighting Mead’s relevance for areas of research completely ignored by p...

  19. Traduire la bêtise. Entretien avec Hans-Horst Henschen

    Directory of Open Access Journals (Sweden)

    Hans-Horst Henschen

    2012-03-01

    Full Text Available Quand il entreprend de traduire l’ensemble du corpus Bouvard et Pécuchet, Hans-Horst Henschen est déjà un traducteur reconnu. Ses traductions et/ou éditions de Barthes, Lévi-Strauss, Lyotard, Althusser, Michel Serres ou Jean Starobinski font de lui en Allemagne un relais important de la pensée française. Et à ces traductions d’auteurs ou de courants critiques, s’ajoutent celles qui s’y rattachent par raccroc ; celles qui semblent au contraire quitter les champs de l’anthropologie, de la psych...

  20. Forests of Fortune? The Environmental History of Southeast Borneo, 1600-1880, Han Knapen

    OpenAIRE

    Wadley, Reed L.

    2017-01-01

    Southeast Borneo has long felt the influence of outside forces, and its various peoples, whether indigenous or migrant, have also helped to shape it over long periods of time. How these things have played out in the history of a variable and uncertain environment is the subject of Han Knapen’s book. A product of the “Ecology, Demography and Economy in Nusantara” project of the Dutch Royal Institute of Anthropology and Linguistics (KITLV) in Leiden, it is the first of its kind for the island o...

  1. Savage Nature and Noble Spirit in Han Sorya's Wolves: A North Korean Morality Tale

    Directory of Open Access Journals (Sweden)

    Alzo David-West

    2012-05-01

    Full Text Available Peer reviewed article. This paper is a narratological study of Han Sorya's Wolves, a canonical novelette in the tradition of North Korean socialist realism that has been adjudicated outside North Korea as anti-American, anti-Christian, and extremely racist. The novelette, however, is a more metaphorical, hybrid, and complicated piece of writing than has previously been assumed. Descriptive and interpretative narratological analysis reveals that Wolves is a patriotic-proletarian morality tale against colonialism, imperialism, racism, and war. The story also reveals grand metaphysical and normative Neo-Confucian imperatives, which operate as moral shaping principles that are interwoven into character, plot, and theme.

  2. Hans Kelsen – The Reception of “Pure Theory” in South America, Particularly in Brazil

    OpenAIRE

    Carlos Eduardo de Abreu Boucault

    2015-01-01

    This article aims to examine the reception of « Pure theory of Law », of Hans Kelsen in some South-American countries, throughout institutional approaches and also the diffusion of this theory as well its acceptance by cultural agents who represented academic and professional law environment, in Uruguay, Colombia, Argentina and Brazil. The historical period of this study concerns the early times of 40 till our days. Although the reference of Kelsen’s thought about theory of law may appear as ...

  3. Mismatch Negativity in Han Chinese Patients with Schizophrenia: A Meta-Analysis.

    Science.gov (United States)

    Xiong, Yanbing; Ll, Xianbin; Zhao, Lei; Wang, Chuanyue

    2017-10-25

    Previous meta-analysis revealed that mismatch negativity(MMN) amplitude decreased in patients with schizophrenia compared with healthy controls (Cohen's d, d about 1), leading to the possibility of mismatch negativity being used as a biomarker for schizophrenia. However, it is unknown whether MMN is reliably changed in Chinese patients. It is necessary to carry out a meta-analysis on MMN of Han Chinese patients with schizophrenia. To investigate whether MMN could be used as a biomarker for Han Chinese patients with schizophrenia. A literature search was conducted to identify clinical trials on MMN in Han Chinese schizophrenia patients published before May 8, 2017, by searching the Chinese language databases CNKI, WanFang Data, VIP Data and PubMed. The effects of MMN deficits were evaluated for MMN amplitude by calculating standard mean difference (SMDs) between schizophrenia patient groups and healthy control groups. A total of 11 studies were included in the analysis. The total quality of all the studies were more than 6 as evaluated by Newcastle-Ottawa Scale (NOS). Meta-analysis of data from these studies had a pooled sample of 432 patients with schizophrenia and 392 healthy controls. There exists significant MMN deficit in schizophrenia patients compared to healthy controls (Cohen's d =1.004). When studies were excluded due to heterogeneity, the pooled effect size of the MMN differences between the patient group and healthy controls dropped to 0.79 (Cohen's d =0.79). Subgroup analysis showed that MMN amplitude deficits of schizophrenia over three years had the pooled effect size of 0.95, and less than three years had the pooled effect size of 0.77. Publication bias conducted via Egger regression test ( t = 1.83; p = 0.101), suggested that there was no publication bias. The effect size of MMN amplitude between Chinese patients with schizophrenia and healthy controls is consistent with other meta-analyses published on this topic, suggesting that Han Chinese

  4. Huella de Hans-Georg Gadamer en Reinhart Koselleck. Aportes a la historia conceptual

    OpenAIRE

    Ramos Rodríguez, Froilán

    2018-01-01

    Resumen Este artículo analiza la influencia de la hermenéutica de Hans-Georg Gadamer (1900-2002) sobre la historia conceptual de Reinhart Koselleck (1923-2006), así como la relación intelectual entre ambos. En este sentido, se hace una revisión de los principales rasgos biográficos de ambos académicos, y un reexamen de las ideas -de temporalidad y lenguaje-, que inspiraron y contribuyeron en su formación y obras, para analizar las premisas primordiales de sus trabajos, en Verdad y método, Fut...

  5. Ethical foundation of the sustainable development in kant, habermas and hans jonas

    OpenAIRE

    Camargo, Sérgio Xavier de; Universidade Estadual de Londrina - UEL; Pinheiro, Ana Cláudia Duarte; Universidade Estadual de Londrina - UEL

    2010-01-01

    A possibilidade de desenvolvimento econômico associado à preservação ambiental é questão relevante para as sociedades contemporâneas. O desenvolvimento sustentável fundamenta-se em questões de conteúdo ético que transcendem aspectos legais, econômicos e políticos. É objetivo deste artigo investigar, em Immanuel Kant, Jürgen Habermas e Hans Jonas, as bases éticas justificadoras do desenvolvimento sustentável. Em Kant, o imperativo categórico, a valorização da universalidade das ações, e a comp...

  6. HANS KÜNG ile KÜRESEL AHLAK ÜZERİNE

    OpenAIRE

    Eren, Mustafa

    2015-01-01

    Global ethics has as an existential significance in Hans Küng?s philosophical thought. Küng prefers the term ?ethos? for his theory as it has   deeper  and more unfathomable implications than ethics and moral. Tragedies of humankind during past two centuries have the stimulating  power for Küng. He has in his mind all these human casualties when he thinks about theology and philosophy and finally he dwelled on ethos within which he tried to handle these everlasting existential issues. The fol...

  7. Hans Küng se voorstel vir ’n eietydse etiek

    Directory of Open Access Journals (Sweden)

    S. A. Strauss

    1998-06-01

    Full Text Available This contribution undertakes a critical assessment of the well-known Hans Küng's proposal for contemporary ethics in his book Global responsibility. In search of a new world ethic (1990. This article commences by providing some background on this publication as well as on the theology of Küng in general. The content of the book is then paraphrased in summarised form. The last part of the article analyses four major convictions of Kung, against which the Reformed doctrine is brought forward. These convictions deal with the ethical aspects of normativity, humanity, postmodernity and ecumenicity.

  8. The comparison of coronary arteries imaging features between Uygur and Han populations in Xinjiang with 64-slice spiral CT

    International Nuclear Information System (INIS)

    Pan Cunxue; Zhao Yanping; Liu Wenya; Wang Haitao; Dang Jun; Yang Wen; Sun Yajing; Li Xiaoyu

    2010-01-01

    Objective: To analyze the imaging findings of coronary angiography using 64-slice row CT and investigate the difference of coronary artery's morphological characteristics between Uygur and Han populations. Methods: A retrospective study was made to coronary CT angiographic images of 88 Uygur cases matched with 88 Han cases. The data were analyzed with X 2 test and paired Wilcoxon test. Results: The coronary CT angiographic findings were different between Uygur population and Han population in the following aspects: there were 62, 18, and 8 cases with the left coronary artery originating from intra-sinus, para-sinus and extra-sinus location respectively in Uygur population, while there were 73, 14, and 8 cases in Han population respectively (t=8319, P 2 =5.8381, P 2 =5.1948, P<0.05). The cases with LCA variations were 28 and 49 cases in the two populations respectively (t=2692, P<0.05) and the number with RCA variations were 33 and 27 cases in the two populations respectively (t=968, P<0.05). Conclusions: There are lots of differences of the coronary artery morphology between the Uygur and Han populations. Firstly, these differences may be related to different patterns in coronary angiography. Secondly, these differences may be related to differences between Uygur and Han populations in the incidence and severity of coronary heart disease. (authors)

  9. A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese.

    Science.gov (United States)

    Qin, Pengfei; Li, Zhiqiang; Jin, Wenfei; Lu, Dongsheng; Lou, Haiyi; Shen, Jiawei; Jin, Li; Shi, Yongyong; Xu, Shuhua

    2014-02-01

    Population stratification acts as a confounding factor in genetic association studies and may lead to false-positive or false-negative results. Previous studies have analyzed the genetic substructures in Han Chinese population, the largest ethnic group in the world comprising ∼20% of the global human population. In this study, we examined 5540 Han Chinese individuals with about 1 million single-nucleotide polymorphisms (SNPs) and screened a panel of ancestry informative markers (AIMs) to facilitate the discerning and controlling of population structure in future association studies on Han Chinese. Based on genome-wide data, we first confirmed our previous observation of the north-south differentiation in Han Chinese population. Second, we developed a panel of 150 validated SNP AIMs to determine the northern or southern origin of each Han Chinese individual. We further evaluated the performance of our AIMs panel in association studies in simulation analysis. Our results showed that this AIMs panel had sufficient power to discern and control population stratification in Han Chinese, which could significantly reduce false-positive rates in both genome-wide association studies (GWAS) and candidate gene association studies (CGAS). We suggest this AIMs panel be genotyped and used to control and correct population stratification in the study design or data analysis of future association studies, especially in CGAS which is the most popular approach to validate previous reports on genetic associations of diseases in post-GWAS era.

  10. Inner and inter population structure construction of Chinese Jiangsu Han population based on Y23 STR system

    Science.gov (United States)

    Yang, Chun; Zhang, Jianqiu

    2017-01-01

    In this study, we analyzed the genetic polymorphisms of 23 Y-STR loci from PowerPlex® Y23 system in 916 unrelated healthy male individuals from Chinese Jiangsu Han, and observed 912 different haplotypes including 908 unique haplotypes and 4 duplicate haplotypes. The haplotype diversity reached 0.99999 and the discrimination capacity and match probability were 0.9956 and 0.0011, respectively. The gene diversity values ranged from 0.3942 at DYS438 to 0.9607 at DYS385a/b. Population differentiation within 10 Jiangsu Han subpopulations were evaluated by RST values and visualized in Neighbor-Joining trees and Multi-Dimensional Scaling plots as well as population relationships between the Jiangsu Han population and other 18 Eastern Asian populations. Such results indicated that the 23 Y-STR loci were highly polymorphic in Jiangsu Han population and played crucial roles in forensic application as well as population genetics. For the first time, we reported the genetic diversity of male lineages in Jiangsu Han population at a high-resolution level of 23 Y-STR set and consequently contributed to familial searching, offender tracking, and anthropology analysis of Jiangsu Han population. PMID:28704439

  11. Inner and inter population structure construction of Chinese Jiangsu Han population based on Y23 STR system.

    Directory of Open Access Journals (Sweden)

    Huipin Wang

    Full Text Available In this study, we analyzed the genetic polymorphisms of 23 Y-STR loci from PowerPlex® Y23 system in 916 unrelated healthy male individuals from Chinese Jiangsu Han, and observed 912 different haplotypes including 908 unique haplotypes and 4 duplicate haplotypes. The haplotype diversity reached 0.99999 and the discrimination capacity and match probability were 0.9956 and 0.0011, respectively. The gene diversity values ranged from 0.3942 at DYS438 to 0.9607 at DYS385a/b. Population differentiation within 10 Jiangsu Han subpopulations were evaluated by RST values and visualized in Neighbor-Joining trees and Multi-Dimensional Scaling plots as well as population relationships between the Jiangsu Han population and other 18 Eastern Asian populations. Such results indicated that the 23 Y-STR loci were highly polymorphic in Jiangsu Han population and played crucial roles in forensic application as well as population genetics. For the first time, we reported the genetic diversity of male lineages in Jiangsu Han population at a high-resolution level of 23 Y-STR set and consequently contributed to familial searching, offender tracking, and anthropology analysis of Jiangsu Han population.

  12. Clinical study on the expression differences of biochemical indicators between Uygur and Han patients with diabetic retinopathy

    Directory of Open Access Journals (Sweden)

    Jing-Li Han

    2016-02-01

    Full Text Available AIM:To detect the related biochemical indicators of the Uygur and Han patients with diabetic retinopathy,to judge progression of diabetic retinopathy and evaluate the relation between ethnic and progression. So as to give a more accurate guide for regional clinical treatment, early detection, early prevention, reduce concurrency disease and improve quality of life. METHODS:One hundred and twenty patients with diabetic retinopathy aged 38~70 were diagnosed by fundus fluorescein angiography, including 60 patients with non-proliferative diabetic retinopathy(NPDR, 30 Uygur and Han respectively(devided into Uygur group 1, Han group 1; 60 patients with proliferative diabetic retinopathy(PDR, 30 Uygur and Han respectively(devided into Uygur group 2, Han group 2. All patients were detected for high-sensitivity C-reactive protein(hs-CRP, serum total bilirubin(TBIL, fibrinogen(FIB, D-dimer(DDindicators using fasting blood. RESULTS:Regardless of ethnic, NPDR group and PDR group were significant differences in the four indicators; there was no significant difference between the Han and the Uygur group on the hs-CRP. But for the TBIL, FIB and DD, it was significantly different between the two ethnical groups, and it was more obvious in Uygur group. CONCLUSION:Diabetic retinopathy generally was more severe in Xinjiang Uygur groups, more attention should be paid in clinical practice.

  13. Genetic variations in MTHFR and esophageal squamous cell carcinoma susceptibility in Chinese Han population.

    Science.gov (United States)

    Tang, Weifeng; Zhang, Sheng; Qiu, Hao; Wang, Lixin; Sun, Bin; Yin, Jun; Gu, Haiyong

    2014-05-01

    Esophageal cancer is the sixth most common cancer worldwide. Esophageal squamous cell carcinoma (ESCC) is a fatal malignancy associated with low 5-year survival rate. The aim of this study was to assess the association between methylenetetrahydrofolate reductase (MTHFR) tagging single nucleotide polymorphisms (SNPs) rs1801133 C>T, rs3753584 A>G, rs4845882 G>A, rs4846048 A>G and rs9651118 T>C genotypes and ESCC susceptibility in a hospital-based case-control study. We conducted genotyping analyses for these five SNPs with 629 ESCC cases and 686 controls in a Chinese Han population. Ligation detection reaction method was used to identify genotypes of these MTHFR SNPs. Our results demonstrated that MTHFR rs1801133 C>T was associated with the risk of ESCC; however, MTHFR rs4845882 G>A and rs4846048 A>G SNPs were associated with the decreased risk of ESCC, and MTHFR rs3753584 A>G and rs9651118 T>C SNPs were not associated with ESCC risk. Our findings suggests that MTHFR rs1801133 C>T, rs4845882 G>A and rs4846048 A>G SNPs may be genetic modifiers for developing ESCC in Chinese Han population.

  14. [A Survey for Colton and Other 3 Rare Blood Group Systems in Chinese Nanjing Han Population].

    Science.gov (United States)

    Chen, Yan; Ma, Ling; Liu, Yan-Chun

    2015-10-01

    To investigate the distribution of Colton, Diego, Kell and Yt rare blood groups in Chinese Nanjing Han population, so as to improve the transfusion capability of patients with rare blood group and to further enrich the rare-blood-donor bank. A total of 2 015 blood samples from the blood donors were selected randomly to screen the presence of K⁺ and Kp(c+) (Kell), Yt(b+) (Yt), Co(b+) (Colton), Di(a+b+) and Di(a+b-) (Digeo) antigen allele by using PCR and multiplex PCR. Out of 2005 samples, 1 case with K⁺ gene, 8 cases with Yt(b+) gene and 100 cases with Di(a+b+) gene, 2 cases with Di(a+b-) were identified, while no Kp(c+) and Co(b+) were detected. The frequencies of K⁺, Yt(b+) and Di(a+), Di(b+) are 0.0003, 0.0013 and 0.0258, 0.9742, respectively. They are very rare blood groups in Chinese Nanjing Han population.

  15. Hans Georg Trüper (1936–2016 and His Contributions to Halophile Research

    Directory of Open Access Journals (Sweden)

    Aharon Oren

    2016-05-01

    Full Text Available Prof. Hans Georg Trüper, one of the most important scientists in the field of halophile research, passed away on 9 March 2016 at the age of 79. I here present a brief obituary with special emphasis on Prof. Trüper’s contributions to our understanding of the halophilic prokaryotes and their adaptations to life in hypersaline environments. He has pioneered the study of the halophilic anoxygenic phototrophic sulfur bacteria of the Ectothiorhodospira—Halorhodospira group. Some of the species he and his group isolated from hypersaline and haloalkaline environments have become model organisms for the study of the mechanisms of haloadaptation: the functions of three major organic compounds – glycine betaine, ectoine, and trehalose – known to serve as “compatible solutes” in halophilic members of the Bacteria domain, were discovered during studies of these anoxygenic phototrophs. Prof. Trüper’s studies of hypersaline alkaline environments in Egypt also led to the isolation of the first known extremely halophilic archaeon (Natronomonas pharaonis. The guest editors dedicate this special volume of Life to the memory of Prof. Hans Georg Trüper.

  16. Genetic polymorphisms in ALDH2 are associated with drug addiction in a Chinese Han population.

    Science.gov (United States)

    Zhang, Chan; Ding, Heng; Cheng, Yujing; Chen, Wanlu; Li, Qi; Li, Qing; Dai, Run; Luo, Manlin

    2017-01-31

    We investigated the association between single nucleotide polymorphisms (SNPs) in ALDH2, which has been associated with alcohol dependence and several types of diseases, and the risk of drug addiction in a Chinese Han population. In a case-control study that included 692 cases and 700 healthy controls, eight SNPs in ALDH2 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender. We determined that rs671 is significantly associated with a 1.551-fold increased drug addiction risk (95% CI = 1.263-1.903; p drug addiction under additive, dominant and recessive models (p drug addiction risk under additive and recessive model, respectively (p drug addiction risk (OR = 1.668; 95% CI, 1.328-2.094, p drug addiction risk (OR = 0.444; 95% CI, 0.281-0.704, p drug addiction in the Chinese Han population.

  17. Association of a miRNA-137 Polymorphism with Schizophrenia in a Southern Chinese Han Population

    Directory of Open Access Journals (Sweden)

    Guoda Ma

    2014-01-01

    Full Text Available Both genome wide association study (GWAS and biochemical studies of Caucasian populations indicate a robust association between the miR-137 genetic variant rs1625579 and schizophrenia, but inconsistent results have been reported. To assay the association between this variant and schizophrenia, we genotyped 611 schizophrenic patients from Southern Chinese Han population for the risk single nucleotide polymorphism (SNP rs1625579 using the SNaPshot technique and compared the clinical profiles of different genotypes. Additionally, a meta-analysis was performed using the combined sample groups from five case-control publications and the present study. Both the genotype and allele distributions of the rs1625579 SNP were significantly different between patients and controls (P=0.036 and 0.026, SNP. TT genotype carriers showed slightly lower Brief Assessment of Cognition in Schizophrenia- (BACS- derived working memory performance than G carriers (15.58 ± 9.56 versus 19.71 ± 8.18, P=0.045. In the meta-analysis, we observed a significant association between rs1625579 and schizophrenia under different genetic models (all P<0.05. The results of our study and meta-analysis provide convincing evidence that rs1625579 is significantly associated with schizophrenia. Furthermore, the miR-137 polymorphism influences the working memory performance of schizophrenic patients in a Chinese Han population.

  18. Hans Ballmer : la poesía y el movimiento de la aniquilación

    Directory of Open Access Journals (Sweden)

    Constanza Nieto Yusta

    2006-01-01

    Full Text Available En la producción artística de Hans Bellmer confluyen factores que se inscriben tanto en el ámbito de la creación artística como en el mundo especulativo. Es en este sentido cómo pueden entenderse sus famosas poupées, objetos poéticos y científicos a través de los cuales es posible desgranar aquellos temas que obsesionaron al artista desde su más temprana juventud y que engloban desde los temores inocentes y los juegos de la primera infancia hasta la posterior exploración de la aniquilación a través del veneno, la sexualidad y el movimiento.The artistic production of the surrealist Hans Bellmer shows the importance of two elements, opposed in appearance: Poetry and Science. Is in this sense how his lifesize dolls can be considered, as poetic and scientific objects where it is possible to find the subjects that turned into obsessions since his most early childhood: games, science mechanisms, poison, sexuality, movement and death.

  19. Impact of strabismus on the quality of life of Chinese Han teenagers

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    Tu CS

    2016-06-01

    Full Text Available Changsen Tu, Liang Ye, Longfei Jiang, Yuwen Wang, Yingzi Li The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, People’s Republic of China Background: Although much research has been conducted on the impact of strabismus on the quality of life (QoL of adults, the effect of this condition on teenagers has not been extensively studied. This study therefore aimed to assess the effect of strabismus on the vision-related QoL of Chinese teenagers.Methods: The Chinese version of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25 was self-administered by 1,040 teenagers with strabismus and 1,002 individuals with normal vision. All the participants were from the Chinese Han population. The independent samples t-test was used to compare QoL between teenagers with and without strabismus.Results: The majority of scores on the NEI-VFQ-25 domains were significantly different between the two groups. QoL was significantly lower in individuals with strabismus compared with teenagers with normal vision on all domains, with the exception of social functioning.Conclusion: Statistically significantly lower vision-related QoL scores were found in Chinese Han teenagers with strabismus compared with those without strabismus. Keywords: quality of life, strabismus, NEI-VFQ-25, teenager, HRQoL

  20. Characterization of mitochondrial DNA polymorphisms in the Han population in Liaoning Province, Northeast China.

    Science.gov (United States)

    Xu, Feng-Ling; Yao, Jun; Ding, Mei; Shi, Zhang-Sen; Wu, Xue; Zhang, Jing-Jing; Wang, Bao-Jie

    2018-03-01

    This study characterized the genetic variations of mitochondrial DNA (mtDNA) to elucidate the maternal genetic structure of Liaoning Han Chinese. A total of 317 blood samples of unrelated individuals were collected for analysis in Liaoning Province. The mtDNA samples were analyzed using two distinct methods: sequencing of the hypervariable sequences I and II (HVSI and HVSII), and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of the coding region. The results indicated a high gene diversity value (0.9997 ± 0.0003), a high polymorphism information content (0.99668) and a random match probability (0.00332). These samples were classified into 305 haplotypes, with 9 shared haplotypes. The most common haplogroup was D4 (12.93%). The principal component analysis map, the phylogenetic tree map, and the genetic distance matrix all indicated that the genetic distance of the Liaoning Han population from the Tibetan group was distant, whereas that from the Miao group was relatively close.

  1. Vooruitgang en ondergang: historiese dialektiek in twee tekste van Hans Magnus Enzensberger

    Directory of Open Access Journals (Sweden)

    J.P.C. van den Berg

    2006-07-01

    Full Text Available Progress and decline: historical dialect in two texts by Hans Magnus Enzensberger The interpretation of history as a process of dialectical development has been one of the most important ideas of Marxist philosophy. Whereas earlier Marxists optimistically considered this process as steering inevitably towards a sociopolitical utopia, subsequent thinkers in the Marxist tradition, especially those identified as Neo-Marxists (like Theodor Adorno, had a more pessimistic interpretation of dialectics. Influenced especially by Adorno, German poet and social commentator Hans Magnus Enzensberger uses the concept of “historical dialectics” as a seminal theme in two of his literary works: “Mausoleum: siebenunddreißig Balladen aus der Geschichte des Fortschritts” and “Der Untergang der Titanic”. In these two texts the representation of the ambiguity of “Fortschritt” or historical development presupposes a more pessimistic account of the historical process. This ambiguity is present both in a bird’s-eye view of the historical process (“Mausoleum”, and in the focus on one specific historical incident (“Der Untergang der Titanic”. Enzensberger subsequently continues to consider the role of art within this dialectical context. In this article, both Enzensberger’s literary use of the philosophical concept of historical dialectics and its artistic implications (as identified by him are examined.

  2. Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

    Science.gov (United States)

    Retsas, Spyros

    2012-12-01

    In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

  3. Platelet glycoprotein IaC807T polymorphisms and ischemic stroke in young Chinese Han population.

    Science.gov (United States)

    Zhang, J; Huang, D; Yang, J; An, H; Ojha, R; DU, C; Liu, R

    2012-11-01

    The objective of this study was to investigate the association between platelet glycoprotein (GP) Ia C807T polymorphisms and ischemic stroke in young Chinese Han Population. We conducted a case-control study in 92 consecutive young (ischemic stroke inpatients and outpatients, 86 elder ischemic stroke control (> 50 years), and 160 age- and sex-matched healthy control. Genotyping of platelet GP Ia C807Tpolymorphisms was performed by polymerase chain reaction followed by sequencing nucleic acid with dideoxy chain-termination method and an ABI PRISM3100 (Perkin-Elmer Co) genetic analyzer. Student's t-test, chi-square test, and logistic regression modeling were used for data significance analyses. Hypertension and smoking were found to be the independent risk factors for ischemic stroke patients (aged ischemic stroke patients (aged > 50 years). There was no significant difference observed in the T allele frequency of GPIa C807T polymorphisms between young stroke patients and corresponding controls. These findings suggest that there is no role of GPIa C807T polymorphisms in the development of young first-ever ischemic stroke in Chinese Han Population.

  4. Association of ATM and BMI-1 genetic variation with breast cancer risk in Han Chinese.

    Science.gov (United States)

    Yue, Li-Ling; Wang, Fu-Chao; Zhang, Ming-Long; Liu, Dan; Chen, Ping; Mei, Qing-Bu; Li, Peng-Hui; Pan, Hong-Ming; Zheng, Li-Hong

    2018-04-24

    We tested the hypothesis that genetic variation in ATM and BMI-1 genes can alter the risk of breast cancer through genotyping 6 variants among 524 breast cancer cases and 518 cancer-free controls of Han nationality. This was an observational, hospital-based, case-control association study. Analyses of single variant, linkage, haplotype, interaction and nomogram were performed. Risk was expressed as odds ratio (OR) and 95% confidence interval (CI). All studied variants were in the Hardy-Weinberg equilibrium and were not linked. The mutant allele frequencies of rs1890637, rs3092856 and rs1801516 in ATM gene were significantly higher in cases than in controls (P = .005, ATM gene were significantly associated with 1.98-fold and 6.04-fold increased risk of breast cancer (95% CI: 1.36-2.90 and 1.65-22.08, respectively). Nomogram analysis estimated that the cumulative proportion of 3 significant variants in ATM gene was about 12.5%. Our findings collectively indicated that ATM gene was a candidate gene in susceptibility to breast cancer in Han Chinese. © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  5. [Hans Gross and the beginning of criminology on a scientific basis].

    Science.gov (United States)

    Bachhiesl, Christian

    2007-01-01

    Modern criminology--if one wants to consider it a separate scientific discipline at all--is usually perceived as being mainly influenced by the methods of natural sciences supplemented by components from the field of psychology, which, at least in some of its conceptions, tends to define itself as a natural science, too. If we take a look at the history of science, we will see development of criminology in this direction was not necessarily inevitable. The scientific work of the Austrian Hans Gross (1847-1915), one of the founding fathers of scientific criminology, serves as an example of the way how natural sciences and their exact methods became established in the methodological apparatus of modern criminology, although in praxi his claim for the application of exact methods was all too often replaced by irrational and intuitive ways of working. Still, Hans Gross' fundamental decision for the exact methods derived from the natural sciences is an important step towards a criminology that can be understood as a part of natural sciences, largely superseding the methods of cultural sciences and anthropological philosophy. This approach made the (criminal) human being an object of measurement and can result in the concept of man as a mere phenomenon of quantity. This is, on the one hand, ethically questionable; on the other hand, it made modern criminology more efficient and successful.

  6. Applicability of the Tanaka-Johnston and Moyers mixed dentition analyses in Northeast Han Chinese.

    Science.gov (United States)

    Sherpa, Jangbu; Sah, Gopal; Rong, Zeng; Wu, Lipeng

    2015-06-01

    To assess applicability of the Tanaka-Johnston and Moyers prediction methods in a Han ethnic group from Northeast China and to develop prediction equations for this same population. Cross-sectional study. Department of Orthodontics, School of Stomatology, Jiamusi University, Heilongjiang, China. A total of 130 subjects (65 male and 65 female) aged 16-21 years from a Han ethnic group of Northeast China were recruited from dental students and patients seeking orthodontic treatment. Ethnicity was verified by questionnaire. Mesio-distal tooth width was measured using Digital Vernier calipers. Predicted values were obtained from the Tanaka-Johnston and Moyers methods in both arches were compared with the actual measured widths. Based on regression analysis, prediction equations were developed. Tanaka-Johnston equations were not precise, except for the upper arch in males. However, the Moyers 85th percentile in the upper arch and 75th percentile in the lower arch predicted the sum precisely in males. For females, the Moyers 75th percentile predicted the sum precisely for the upper arch, but none of the Moyers percentiles predicted in the lower arch. Both the Tanaka-Johnston and Moyers method may not be applied universally without question. Hence, it may be safer to develop regression equations for specific populations. Validating studies must be conducted to confirm the precision of these newly developed regression equations.

  7. Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese.

    Science.gov (United States)

    Zhao, Y; Ding, M; Pang, H; Xu, X M; Wang, B J

    2014-03-12

    Dopamine (DA) has been implicated in the pathophysiol-ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa-mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect gene expression, influence biosynthesis of DA and underlie various neuropsychiatric disorders re-lated to DA dysfunction. The present study explored the association of SNPs within the DRD5 gene with paranoid schizophrenia in Han Chinese. A total of 176 patients with schizophrenia and 206 healthy controls were genotyped for four DRD5 SNPs (rs77434921, rs2076907, rs6283, and rs1800762). Significant group differences were observed in the allele and genotype frequencies of rs77434921 and rs1800762 and in the frequen-cies of GC haplotypes corresponding to rs77434921-rs1800762. Our find-ings suggest that common genetic variations of DRD5 are likely to con-tribute to genetic susceptibility to paranoid schizophrenia in Han Chinese. Further studies in larger samples are needed to replicate this association.

  8. Autonomous dynamics in neural networks: the dHAN concept and associative thought processes

    Science.gov (United States)

    Gros, Claudius

    2007-02-01

    The neural activity of the human brain is dominated by self-sustained activities. External sensory stimuli influence this autonomous activity but they do not drive the brain directly. Most standard artificial neural network models are however input driven and do not show spontaneous activities. It constitutes a challenge to develop organizational principles for controlled, self-sustained activity in artificial neural networks. Here we propose and examine the dHAN concept for autonomous associative thought processes in dense and homogeneous associative networks. An associative thought-process is characterized, within this approach, by a time-series of transient attractors. Each transient state corresponds to a stored information, a memory. The subsequent transient states are characterized by large associative overlaps, which are identical to acquired patterns. Memory states, the acquired patterns, have such a dual functionality. In this approach the self-sustained neural activity has a central functional role. The network acquires a discrimination capability, as external stimuli need to compete with the autonomous activity. Noise in the input is readily filtered-out. Hebbian learning of external patterns occurs coinstantaneous with the ongoing associative thought process. The autonomous dynamics needs a long-term working-point optimization which acquires within the dHAN concept a dual functionality: It stabilizes the time development of the associative thought process and limits runaway synaptic growth, which generically occurs otherwise in neural networks with self-induced activities and Hebbian-type learning rules.

  9. Pen size and parity effects on maternal behaviour of Small-Tail Han sheep.

    Science.gov (United States)

    Lv, S-J; Yang, Y; Dwyer, C M; Li, F-K

    2015-07-01

    The aim of this experiment was to study the effects of pen size and parity on maternal behaviour of twin-bearing Small-Tail Han ewes. A total of 24 ewes were allocated to a 2×2 design (six per pen), with parity (primiparous or multiparous) and pen size (large: 6.0×3.0 m; small: 6.0×1.5 m) as main effects at Linyi University, Shandong Province, China. Behaviour was observed from after parturition until weaning. All ewes were observed for 6 h every 5 days from 0700 to1000 h and from 1400 to 1700 h. Continuous focal animal sampling was used to quantify the duration of maternal behaviours: sucking, grooming and following as well as the frequency of udder accepting, udder refusing and low-pitched bleating. Oestradiol and cortisol concentrations in the faeces (collected in the morning every 5 days) were detected using EIA kits. All lambs were weighed 24 h after parturition and again at weaning at 35 days of age. The small pen size significantly reduced following (Pbehaviour in sheep during lactation. The study is also the first to report on the maternal behaviour of Chinese native sheep breeds (Small-Tail Han sheep), with implications for the production of sheep in China.

  10. Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese

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    Li Sheng-Bin

    2011-10-01

    Full Text Available Abstract Background Monoamine oxidases (MAOs catalyze the metabolism of dopaminergic neurotransmitters. Polymorphisms of isoforms MAOA and MAOB have been implicated in the etiology of mental disorders such as schizophrenia. Association studies detected these polymorphisms in several populations, however the data have not been conclusive to date. Here, we investigated the association of MAOA and MAOB polymorphisms with schizophrenia in a Han Chinese population. Methods Two functional single nucleotide polymorphisms (SNPs, rs6323 of MAOA and rs1799836 of MAOB, were selected for association analysis in 537 unrelated schizophrenia patients and 536 healthy controls. Single-locus and Haplotype associations were calculated. Results No differences were found in the allelic distribution of rs6323. The G allele of rs1799836 was identified as a risk factor in the development of schizophrenia (P = 0.00001. The risk haplotype rs6323T-rs1799836G was associated with schizophrenia in female patients (P = 0.0002, but the frequency difference was not significant among male groups. Conclusions Our results suggest that MAOB is a susceptibility gene for schizophrenia. In contrast, no significant associations were observed for the MAOA functional polymorphism with schizophrenia in Han Chinese. These data support further investigation of the role of MAO genes in schizophrenia.

  11. RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.

    Science.gov (United States)

    Yan, Shouchun; Xia, Ridong; Jin, Tianbo; Ren, Hui; Yang, Hua; Li, Jing; Yan, Mengdan; Zhu, Yuanyuan; Chen, Mingwei

    2016-10-25

    RTEL1 (regulator of telomere elongation helicase 1; OMIM 608833) gene polymorphisms were linked to lung cancer (LC) susceptibility in a cancer genome-wide association study (GWAS) Here, we assessed whether seven previously reported RTEL1 polymorphisms influenced LC risk in Han Chinese population. All study samples (554 LC cases and 696 cancer-free controls) were collected from the Affiliated Hospital of Xizang Minzu University in China. We assessed associations between SNPs and LC risk using various several genetic models (codominant, dominant, recessive, overdominant, and additive). Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model). Haplotype analysis suggested that ''CTC'' was associated with a 0.8-fold decrease in LC risk (OR = 0.80, 95% CI, 0.63-1.00; Pearson's p = 0.05). These findings suggest a potential association between RTEL1 polymorphisms and LC risk in a Chinese Han population.

  12. Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population.

    Science.gov (United States)

    Ding, Yipeng; Xu, Heping; Yao, Jinjian; Xu, Dongchuan; He, Ping; Yi, Shengyang; Li, Quanni; Liu, Yuanshui; Wu, Cibing; Tian, Zhongjie

    2017-01-01

    We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 ( RTEL1 ), which has been associated with telomere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD) in a Chinese Han population. In a case-control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms in RTEL1 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender. In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10-0.82; P =0.02). In the genetic model analysis, we found that the "C/C" genotype of rs4809324 was associated with a decreased risk of COPD based on the codominant model (OR =0.33; 95% CI =0.13-0.86; P =0.022) and recessive model (OR =0.32; 95% CI =0.12-0.80; P =0.009). Our data shed new light on the association between genetic polymorphisms of RTEL1 and COPD susceptibility in the Chinese Han population.

  13. The Life and Works of Han Shin Gwang : a Midwife and Nurse of Korean Modern Times

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    YI Ggodme

    2006-06-01

    Full Text Available Han Shin Gwang, born in an early Christian family in Korea in 1902, could get western education different from the ordinary Korean girls in that period. She participated in the 1919 Samil Independence Movement in her teens, and got nursing and midwifery education in a missionary hospital. She got a midwife license and worked as a member in an early mother-and-child health center. She organized 'Korean Nurses' Association' in 1924 and focused on public health movement as the chairwoman. She actively participated in women's movement organizations, and Gwangjoo Student's Movement. She was known to be a representative of leading working women, and wrote articles on woman's right, the needs and works of nurses and midwives. From late Japanese colonial period, she opened her own clinic and devoted herself to midwifery. After the Korean Liberation in 1945, she began political movement and went in for a senate election. During the Korean War, she founded a shelter for mothers and children in help. After the War, she reopened a midwifery clinic and devoted to the works of Korean Midwives' Association. Han Shin Gwang's life and works belong to the first generation of Korean working women in modern times. She actively participated in women's movement, nurses' and midwives professional movement, Korea liberation movement, and mother-and-child health movement for 60 years. Her life is truly exemplary as one of the first generation of working women in modern Korea, distinguished of devotion and calling.

  14. Association study of STAT4 polymorphisms and type 1 diabetes in Northeastern Chinese Han population.

    Science.gov (United States)

    Bi, C; Li, B; Cheng, Z; Hu, Y; Fang, Z; Zhai, A

    2013-03-01

    Type 1 diabetes (T1D) is an organ-specific, T-cell-mediated disease resulting from the selective destruction of pancreatic β cells. The signal transducer and activator of transcription 4 (STAT4) gene is one of the most interesting genes for the pathogenesis of autoimmune diseases, including T1D. In this study, a case-control study was conducted in a Han population in northeastern China comparing the genotypes of T1D patients to healthy controls for the presence of two single-nucleotide polymorphisms (SNPs) in the STAT4 gene. The study population comprised of 410 T1D patients and 407 healthy individuals. Two SNPs (rs7574865 and rs3024866) of STAT4 were genotyped with Multiplex SNaPShot method. Data were analyzed with spss 13.0 to determine if a statistical association existed between these genotypes and T1D. One of the two SNPs (rs7574865) was strongly associated with T1D in Northeastern Chinese population compared to healthy controls (P < 0.05), whereas the other tested SNP (rs3024866) demonstrated no significant relationship. In conclusion, the STAT4 gene may play an important role in facilitating susceptibility to T1D in this Han Chinese population. © 2013 John Wiley & Sons A/S.

  15. Association of STAT4 polymorphisms with hepatitis B virus infection and clearance in Chinese Han population.

    Science.gov (United States)

    Jiang, Xianzhong; Su, Kunkai; Tao, Jingjing; Fan, Rongli; Xu, Yi; Han, Haijun; Li, Lanjuan; Li, Ming D

    2016-11-01

    Genome-wide association study indicates that STAT4 is a plausible candidate for an association study with HBV-related liver diseases. We aimed to examine the roles of STAT4 polymorphisms on HBV-related liver diseases in a Chinese Han population. We selected 13 SNPs in STAT4 based on the HapMap database to investigate their associations in 3,033 participants. SNP rs7574865 was significantly associated with HBV infection [odds ratio (OR) 1.15; 95 % confidence interval (CI) 1.00, 1.31; P = 0.046] and clearance (OR 1.17; 95 % CI 1.02, 1.33; P = 0.028). Further, haplotype-based association analysis indicated that the haplotype CTCTT, formed by SNPs rs8179673, rs7574865, rs4274624, rs11889341, and rs10168266, was significantly associated with HBV infection (OR 0.87; 95 % CI 0.76, 0.99; P = 0.022) and clearance (OR 0.86; 95 % CI 0.75, 0.99; P = 0.018). Bioinformatics analysis of these SNPs predicted that they participate in transcriptional regulation. Taken together, our findings demonstrate that variants in STAT4 play a critical role in HBV infection and clearance in the Chinese Han population.

  16. Vares ja kana : [valmid] / Ivan Krõlov ; tlk. Eduard Kansa, Mart Raud, Timotheos Kuusik, Johannes Semper, G. Õis, Arnold Tulik, Oskar Urgart, Jaan Kärner, Jakob Tamm, Erni Hiir

    Index Scriptorium Estoniae

    Krõlov, Ivan, 1768(1769)-1844

    2006-01-01

    Sisu: Vares ja Kana ; Moosekandid ; Vares ja Rebane ; Konn ja Härg ; Pirtsakas Näitsik ; Oraakel ; Rukkilill ; Tuli ja Metsatukk ; Hunt ja Talleke ; Pärdik ja Prillid ; Ahvid ; Tihane ; Eesel ; Kotkas ja Kanad ; Võimumees ja Mõttetark ; Koerte sõprus ; Kasujaotus ; Vaat ; Kvartett ; Teekäijad ja Koerad ; Hunt penilas ; Oja ; Rebane ja Mäger ; Rohutirts ja Sipelgas ; Luiskaja ; Kukk ja Pärlitera ; Jänes jahil ; Hunt ja Kägu ; Haug ja Kass ; Peremees ja Sulane ; Voor ; Elevant maavalitsejaks ; Eesel ja Ööbik ; Külamehe kimbatus ; Elevant ja Mops ; Hunt ja tema Kutsikas ; Kass ja Kokk ; Lõvi ja Sääsk ; Aednik ja Filosoof ; Haned ; Siga ; Vanamees ja kolm noorukit ; Kotkas ja Ämblik ; Lehed ja Juured ; Hunt ja Rebane ; Lohe ; Rästas ; Mehhaanik ; Trishka satter ; Tiik ja Jõgi ; Luik, Haug ja Vähk ; Erak ja Karu ; Mesilane ja Kärbsed ; Lõvi jahisaak ; Talupojad ja Jõgi ; Lilled ; Uudishimulik ; Kaastundlik Rebane ; Kogukonna koosolek ; Demjani kalasupp ; Tihane ja Tuvi ; Hiir ja Rott ; Peegel ja Ahv ; Sääsk ja Karjane ; Talupoeg ja Surm ; Hunt ja Karjased ; Lõvi ja Rebane ; Kamm ; Hunt ja Kurg ; Pilv ; Poiss ja Siug ; Maamees ja Siug ; Kägu ja Tuvike ; Kaks Vaati ; Töökas Karu ; Rebane ja Viinamarjad ; Karu võrgus ; Kirjamees ja Röövel ; Mölder ; Siga Tamme all ; Kärbes ja Mesilane ; Ämblik ja Mesilane ; Rebane ja Eesel ; Siug ja Talleke ; Ööbikud ; Peremes ja Lammas ; Kaks Külameest ; Kaks Koera ; Kass ja Ööbik ; Kalade tants ; Haug ; Habemenoad ; Hiired ; Hunt ja Kass ; Karjane ; Orav ; Damaskuse mõõk ; Koer ja Hobune ; Rebane ; Hundid ja Lambad ; Kägu ja Kukk

  17. Haplotype and genetic relationship of 27 Y-STR loci in Han population of Chaoshan area of China

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    Qing-hua TIAN

    2017-04-01

    Full Text Available Objective  To investigate the genetic polymorphisms of 27 Y-chromosomal short tandem repeats (Y-STR loci included in Yfiler® Plus kit in Han population of Chaoshan area, and explore the population genetic relationships and evaluate its application value on forensic medicine. Methods  By detecting 795 unrelated Chaoshan Han males with Yfiler® Plus kit, haplotype frequencies and population genetics parameters of the 27 Y-STR loci were statistically analyzed and compared with available data of other populations from different races and regions for analyzing the genetic distance and clustering relation of Chaoshan Han population. Results  Seven hundred and eighty-seven different haplotypes were observed in 795 unrelated male individuals, of which 779 haplotypes were unique, and 8 haplotypes occurred twice. The haplotype diversity (HD was 0.999975 with discriminative capacity (DC of 98.99%. The gene diversity (GD at the 27 Y-STR loci ranged from 0.3637(DYS391 to 0.9559(DYS385a/b. Comparing with Asian reference populations, the genetic distance (Rst between Chaoshan Han and Guangdong Han was the smallest (0.0036, while it was relatively larger between Chaoshan Han and Gansu Tibetan population (0.0935. The multi-dimensional scaling (MDS plot based on Rst values was similar to the results of clustering analysis. Conclusion  Multiplex detection of the 27 Y-STR loci reveals a highly polymorphic genetic distribution in Chaoshan Han population, which demonstrates the important significance of Yfiler® Plus kit for establishing a Y-STR database, studying population genetics, and for good practice in forensic medicine. DOI: 10.11855/j.issn.0577-7402.2017.03.08

  18. Association of STAT4 gene polymorphism with increased susceptibility of rheumatoid arthritis in a northern Chinese Han subpopulation.

    Science.gov (United States)

    Zhao, Yi; Liu, Xu; Liu, Xia; Su, Yin; Li, Yanmei; Zhang, Xiaoping; Zhu, Lei; Wang, Shiyao; Wang, Tian; Jiang, Quan; Liu, Xiangyuan; Li, Xiaoxia; Huang, Cibo; Jia, Rulin; Lu, Xiaolan; Guo, Jianping; Li, Zhanguo

    2013-04-01

    Several studies have reported STAT4 polymorphism is strongly associated with increased susceptibility to rheumatoid arthritis (RA). However, a study from China showed no association between STAT4 and RA susceptibility in a Chinese Han subpopulation. Since the northern Hans are known to be genetically different from the southern Hans, the aim of this study was to investigate the association of STAT4 polymorphism with RA in a large cohort of a northern Chinese Han subpopulation. 640 RA patients and 662 healthy controls were enrolled. DNA samples were genotyped for STAT4 rs7574865 by direct sequencing. The association of single nucleotide polymorphism (SNP) rs7574865 with RA susceptibility was calculated and the relationship between rs7574865 polymorphism and RA subgroups stratified by clinical features was estimated. We confirmed a significant association of STAT4 rs7574865 polymorphism with RA susceptibility in northern Chinese Han population. The frequency of the minor T allele in RA was significantly higher than in healthy controls (35.2% vs. 31.1%; P = 0.029, OR 1.2 [95% CI 1.02-1.41]). There was also a significant difference in the distribution of the genotypes of SNP rs7574865 between RA patients and healthy controls (P = 0.02). Stratification analyses showed no associations between the genetic risk and clinical/serologic features, but a potential high frequency of TT genotype in a rheumatoid factor-negative subgroup, although it did not reach statistical significance (P = 0.084, OR 2.01 [95% CI 0.91-4.45]). STAT4 rs7574865 is significantly associated with RA susceptibility in northern Chinese Han subpopulations. The genetic differences of Han subpopulations should be considered when genetic susceptibility for diseases is studied. © 2013 The Authors International Journal of Rheumatic Diseases © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  19. Uus trend - kortermajade (rohelised) ühisruumid / Aivo Vahemets

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    Vahemets, Aivo

    2006-01-01

    Arhitekt Liis Keskküla ja kinnisvaraspetsialist Üllar Hinno hindavad uuselamute ümbrust ja sisehoove Tallinnas Kaupmehe 6 (arh. Kalle Vellevoog, Velle Kadalipp), Sõpruse pst. 9 (arh. Tõnu Laigu, Tõnu Laanemäe) ja Tammeõue elurajoonis (arh. Agabus, Endjärv, Truverk Arhitektid OÜ, haljastus Ülle Grishakov - OÜ Kivisilla). Lk. 91 majaelanike kommentaarid

  20. Laulvad kirjanikud Prima Vistal

    Index Scriptorium Estoniae

    2008-01-01

    Kirjandusfestivalist Prima Vista 8.-11. maini Tartus ja laulvate kirjanike kontsertidest: 9. mail Tõnu Trubetsky kontsert ansambliga The Flovers of Romance, 10. mail Villu Tamme, Mathura, Lauri Sommer, Kaarel B. Väljamäe, Andreas Kalkuni, Kauksi Ülle, Merca ja Aapo Ilves

  1. Prediction consistency and clinical presentations of breast cancer molecular subtypes for Han Chinese population

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    Huang Chi-Cheng

    2012-09-01

    Full Text Available Abstract Background Breast cancer is a heterogeneous disease in terms of transcriptional aberrations; moreover, microarray gene expression profiles had defined 5 molecular subtypes based on certain intrinsic genes. This study aimed to evaluate the prediction consistency of breast cancer molecular subtypes from 3 distinct intrinsic gene sets (Sørlie 500, Hu 306 and PAM50 as well as clinical presentations of each molecualr subtype in Han Chinese population. Methods In all, 169 breast cancer samples (44 from Taiwan and 125 from China of Han Chinese population were gathered, and the gene expression features corresponding to 3 distinct intrinsic gene sets (Sørlie 500, Hu 306 and PAM50 were retrieved for molecular subtype prediction. Results For Sørlie 500 and Hu 306 intrinsic gene set, mean-centring of genes and distance-weighted discrimination (DWD remarkably reduced the number of unclassified cases. Regarding pairwise agreement, the highest predictive consistency was found between Hu 306 and PAM50. In all, 150 and 126 samples were assigned into identical subtypes by both Hu 306 and PAM50 genes, under mean-centring and DWD. Luminal B tended to show a higher nuclear grade and have more HER2 over-expression status than luminal A did. No basal-like breast tumours were ER positive, and most HER2-enriched breast tumours showed HER2 over-expression, whereas, only two-thirds of ER negativity/HER2 over-expression tumros were predicted as HER2-enriched molecular subtype. For 44 Taiwanese breast cancers with survival data, a better prognosis of luminal A than luminal B subtype in ER-postive breast cancers and a better prognosis of basal-like than HER2-enriched subtype in ER-negative breast cancers was observed. Conclusions We suggest that the intrinsic signature Hu 306 or PAM50 be used for breast cancers in the Han Chinese population during molecular subtyping. For the prognostic value and decision making based on intrinsic subtypes, further prospective

  2. Influence of Cigarette Smoking on Rheumatoid Arthritis Risk in the Han Chinese Population

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    Jian Yin

    2017-06-01

    Full Text Available ObjectivesCigarette smoking has been shown in European populations to be associated with rheumatoid arthritis (RA susceptibility. This study aims to examine the association of smoking with RA in the Han Chinese population.Methods718 Han Chinese RA patients and 404 healthy controls were studied. The associations of cigarette smoking (current, former or ever vs. never smokers, and pack-years of exposure with RA, anti-cyclic citrullinated peptide antibody (ACPA positive RA, IgM rheumatoid factor (RF positive RA, and baseline radiographic erosions (modified van der Heijde–Sharp scores were assessed. The interaction between smoking and the HLA-DRB1 shared epitope (SE in RA was also examined.ResultsIn this study, 11 (1.53% cases and 6 (1.49% controls were former smokers (p = 0.95, while 95 (13.23% cases and 48 (11.88% controls were current smokers (p = 0.52. Trends toward associations between smoking status (ever vs. never with RA-overall (p = 0.15, OR = 1.44, ACPA-positive RA (p = 0.24, OR = 1.37, RF-positive RA (p = 0.14, OR = 1.46, or the presence of radiographic erosions (p = 0.66, OR = 1.28 were observed although individually here were not statistically significant. There was no evidence of statistical interaction between smoking status (ever vs. never and SE for all RA, ACPA-positive RA, ACPA-negative RA, RF-positive RA, RF-negative RA (p = 0.37, 0.50, 0.24, 0.26, and 0.81 respectively, and the 95% CI for the attributable proportion for all interactions included 0.ConclusionThis is the first study to examine the association of cigarette smoking with RA in the Han Chinese population. This study shows a trend toward an interaction between smoking and SE carriage influencing the risk of RA, though findings were not statistically significant. It is possible that in the presence of universal exposure to heavy air pollution the effect of smoking on RA risk may be obscured.

  3. Modernidad y humanismo civil: debates y perspectivas en torno a la tesis de Hans Baron

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    Sverlij, Mariana

    2013-12-01

    Full Text Available Resumen En 1952, Hans Baron concluye su obra más importante: The Crisis of the early Italian Renaissance, publicada por la Universidad de Princeton en dos volúmenes, en 1955. En ella, Baron desarrolla el concepto de “humanismo civil”, desde el cual analiza el humanismo florentino del siglo XV y, en particular, la obra de Leonardo Bruni. Para Baron, los humanistas florentinos, en su lucha por la libertad de Florencia ante la amenaza de la Milán de los Visconti, articularon una novedosa relación entre intelectualidad y política. Este movimiento intelectual, al mismo tiempo, abrió las puertas al pensamiento moderno. Numerosas críticas recibió, desde entonces, el trabajo de Baron, centralmente, por parte de aquellos que reivindicaron las continuidades entre la Edad Media y el Renacimiento, así como también por parte de los que han leído críticamente el éxito que tuvo la Crisis en las academias norteamericanas y su influencia en la consolidación de la “ideología americana”. El artículo propone una revisión de la tesis de Baron así como de las controversias generadas en torno a ella, para, finalmente, esbozar la posibilidad de revisar el concepto de “humanismo civil” desde la obra de Leon Battista Alberti. Abstract In 1952, Hans Baron finished his most important work, The Crisis of the Early Italian Renaissance, published in two volumes by Princeton University in 1955. In this work, the author expounds on the concept of “civil humanism” which he uses to analyze the Florentine humanism of the fifteenth century, and in particular, Leonardo Bruni’s work. According to Baron, Florentine humanists, fighting for Florence’s freedom against the threat of Visconti’s Milan, developed a novel relationship between intellectualism and politics. This intellectual movement also paved the way for modern thought. Baron’s work has been critically reviewed many times since then, especially, by those who vindicated the

  4. Volume measurement of thalami in normal Chinese Han nationality adults by the high-resolution MRI

    International Nuclear Information System (INIS)

    Ma Shuai; Chen Nan; Guo Yulin

    2012-01-01

    Objective: To measure the volume of thalamus in 1000 healthy Chinese Han nationality adults, and to analyze the relationship between thalamic volume and age, sex, weight and cerebral volume, to provide reliable data for the construction of database of Chinese adults' digital standard brain. Methods: Totally 1000 healthy Chinese adults of Han nationality aged from 18 to 80 years were recruited.They were divided into 5 groups by age: 18-30, 31-40, 41-50, 51-60 and 61-80 years. Each group included 100 males and 100 females. Brain images were obtained on a 1.5 T MR, and the outline of thalami was drawn with Aquariusws software. Then the thalamic volume was calculated automatically. The volumes of left and right thalamus were compared by paired sample t-test. Thalamic volumes of the same side were compared between males and females by independent sample t-test. And thalamic volumes of different age groups were compared by one-way ANOVA. The relationships between thalamic volume and age, sex, weight and cerebral volume were analyzed respectively. Results: The males' standardized volumes of left and right thalamus of healthy Chinese Han nationality adults were (5776 ± 780), (5655 ± 759) mm 3 , and they were (5464 ±573), (5360 ± 542) mm 3 for female. The males' thalamic volume was more than the females' on the same side (t=2.245, 2.200, P<0.01). The left thalamic volumes of various age groups were (6180 ± 534), (6047 ± 562), (5426 ± 471), (5552 ± 526), (4866 ± 552) mm 3 , respectively, while the right thalamic volumes of the 5 groups were (6069 ± 532), (5895 ± 539), (5357 ± 480), (5396 ± 445),(4791 ± 558)mm 3 , respectively. There were statistically significant difference among the 5 groups (F=165.686, 165.235, P<0.01). The left and right thalamic volume were all negatively correlated with age (r=-0.633, -0.645, P<0.05). Conclusions: With high resolution 1.5 T MR scanner,grey matter and white matter can be depicted clearly and the outline

  5. Blazing a trail: an interview with Conergy's Hans-Martin Rueter

    International Nuclear Information System (INIS)

    Rueter, H.M.; Jones, J.

    2006-01-01

    The Conergy company, based in Hamburg, is active on five continents and is one of the world's most successful renewable energy businesses. Its turnover is about 800 million Euros and it has a staff of 1200. Hans-Martin Rueter founded the company in 1998 and is currently its Chief Executive Officer. In an interview, he revealed that he expects the renewables market will be worth US$300 billion by 2015. He sees three major market sectors to be exploited: they are (a) power-plant scale installations; (b) 'solitaire' installations such as homeowners might purchase and (c) network systems using a combination of systems such as PV with wind. Rueter is already expanding into new markets worldwide and becoming less dependent on the German market. He explains his strategy for finding new markets and providing what the customer wants. (author)

  6. Ein unbekanntes Meisterwerk altdeutscher Glaskunst: Hans Wertingers gläserne Hostienschale von 1498

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    Koreny, Fritz

    2010-08-01

    Full Text Available This hitherto unknown glass paten with églomisé painting, dated 1498 and measuring 36 cm in diameter, depicts the meeting of Abraham and Melchisedek. The painting can be attributed to Hans Wertinger, an artist from Landshut, who is well known for his paintings and stained glass. The recently discovered paten is executed in a refined églomisé technique with painting, scratching-out and with underlayers of gold and silver leaf, making it one of the earliest and finest examples of this technique, not only for Bavarian early Renaissance art but worldwide. The paten thus sheds fresh light on Wertinger as it shows him as an highly trained artist who worked also with bravura in the art of verre églomisé.

  7. PIXE analysis of western han dynasty ancient glasses unearthed in Yangzhou city

    International Nuclear Information System (INIS)

    Li Qinghui; Gu Donghong; Gan Fuxi; Zhang Bin; Ma Bo; Cheng Huansheng

    2003-01-01

    Chemical composition analysis is one of the most important research aspects to provide scientific proof for the technical origin and development of Chinese ancient glass. Proton induced X-ray emission (PIXE) technique is a kind of multi-element quantitative analysis method with high sensitivity and without destruction of samples. Chemical composition of the Western Han dynasty glass garment flakes, which were excavated from Yangzhou city, was analyzed by PIXE, quantitatively. It was found that these glass flakes were attributed to PbO-BaO-SiO 2 glass originated in China. These flakes all consist of a glass core and a corroded outer layer with different thickness. There are relatively higher PbO, P 2 O 5 and CaO, while much lower BaO and SiO 2 in the corroded layers than in the glass cores. The experimental results were discussed

  8. HANS GEORG BECKAND BYZANTINE THEOLOGY. ON THE OCCASION OF THE 100TH ANNIVERSARY OF HIS BIRTH

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    PETER SCHREINER

    2011-08-01

    Full Text Available The life of Hans Georg Beck may be divided into two parts. Until 1944, he was known by his religious name of Hildebrand as a Benedictine monk and priest and was the product of a thorough theological education. He then abandoned both the priesthood and the Church and began a university career devoted to Byzantine studies, eventually emerging as one of the most outstanding authorities in his fi eld. In spite of this all, theology remained for him a principle focus of his interest and it guided his entire academic work, even when it was really not expected to play a role. Beck obviously did not want to be theologian but he did much to convince others that “Byzantine studies without any knowledge of Byzantine theology and the Church in the Byzantine Empire is quite a hopeless aff air, however hard one may try”

  9. P50 suppression deficits and psychopathology in Han Chinese patients with schizophrenia.

    Science.gov (United States)

    Zhu, Xiao Lin; Tan, Shu Ping; Wang, Zhi Ren; Zhang, Jin Guo; Li, Dong; Fan, Feng Mei; Zhao, Yan Li; Zou, Yi Zhuang; Tan, Yun Long; Yang, Fu De; Zhang, Xiang Yang

    2017-07-13

    Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patterns and their correlations with clinical symptoms in a large sample of Han Chinese patients with schizophrenia. We assessed P50 sensory gating with a 64-channel electroencephalography system in 133 patients with schizophrenia and 148 healthy controls. The schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS). Patients with schizophrenia had a significantly higher P50 gating ratio (pschizophrenia. These findings suggest that the P50 sensory gating deficits identified in Chinese patients with schizophrenia may not be involved in the psychopathology of the illness. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Re-reading "Little Hans": Freud's case study and the question of competing paradigms in psychoanalysis.

    Science.gov (United States)

    Midgley, Nicholas

    2006-01-01

    Psychoanalysts have long recognized the complex interaction between clinical data and formal psychoanalytic theories. While clinical data are often used to provide "evidence" for psychoanalytic paradigms, the theoretical model used by the analyst also structures what can and cannot be seen in the data. This delicate interaction between theory and clinical data can be seen in the history of interpretations of Freud's "Analysis of a Phobia in a Five-Year-Old Boy" ("Little Hans"). Freud's himself revised his reading of the case in 1926, after which a number of psychoanalysts--including Melanie Klein, Jacques Lacan, and John Bowlby--reinterpreted the case in the light of their particular models of the mind. These analysts each found "evidence" for their theoretical model within this classic case study, and in doing so they illuminated aspects of the case that had previously been obscured, while also revealing a great deal about the shifting preoccupations of psychoanalysis as a field.

  11. Role of the Bulgarian nuclear regulatory body on the development of the Novi Han repository

    International Nuclear Information System (INIS)

    Batandjieva, B.

    2000-01-01

    The state control over the safe atomic energy utilisation and nuclear material accounting, storage and transportation is carried out by the Committee on the Use of Atomic Energy for Peaceful Purposes, through the Inspectorate on Safe Use of Atomic Energy. The main responsibilities of the Bulgarian Nuclear Safety Authority in the field of radioactive waste management as: state policy; development of concept and programmes; co-ordination and financing of research studies; definition of requirements on the safe use of atomic energy; collection and provision of information on events, related to the radiation protection and nuclear safety; co-ordination of the control over the use of atomic energy; definition of measurements and leading remediation actions are described. The main achievements and the future challenges related to the Novi Han repository are also given

  12. First survey of parasitic helminths of goats along the Han River in Hubei Province, China.

    Science.gov (United States)

    Yang, Xin; Gasser, Robin B; Fang, Rui; Zeng, Jinrong; Zhu, Kaixiang; Qi, Mingwei; Zhang, Zongze; Tan, Li; Lei, Weiqiang; Zhou, Yanqin; Zhao, Junlong; Hu, Min

    2016-09-01

    Diseases caused by parasitic helminths cause considerable production and economic losses in livestock worldwide. Understanding the epidemiology of these parasites has important implications for controlling them. The main purpose of the present study was to estimate the prevalence of key parasitic helminths in goats along the Han River in Zhanggang, Hubei Province (from January to December 2014). We used faecal flotation and sedimentation techniques as well as PCR-based DNA sequencing to detect and identify helminths. Results showed that the prevalence of helminths was high throughout the year, particularly for gastrointestinal nematodes. These first findings provide useful baseline information for goat helminths in Zhanggang, and a starting point for the implementation of control programs. With an increased expansion of the goat industry in China, the findings also emphasise the need to undertake prevalence surveys in other regions of China where extensive farming practices are used.

  13. FAIRY-TALE REALISM. HANS CHRISTIAN ANDERSEN AND THE MODERN WORLD OF THINGS

    Directory of Open Access Journals (Sweden)

    Frederike Felcht

    2013-01-01

    Full Text Available According to recent research in literary studies, literature has a specific knowledge about things. My contribution supports this thesis by analyzing the world of things in Hans Christian Andersen's fairy tales. Exemplary readings reveal how Andersen's texts acknowledge the power of things in modern life and how these texts thus question scientific and philosophical concepts of subjectivity that dominated in the nineteenth century. The agency of things in Andersen's texts challenges the ideal of a rational subject that acts autonomously. Current theoretical approaches, notably Actor-Network-Theory, allow us to understand the realism of acting things in Andersen's work. That which is marvelous, which is prevalently used to define the genre Fairy Tale in literary studies, is inherent to modernity. The relationship between magic and modernity is different than expected: modernity consists of an interplay between enchantment and disenchantment

  14. FAIRY-TALE REALISM. HANS CHRISTIAN ANDERSEN AND THE MODERN WORLD OF THINGS

    Directory of Open Access Journals (Sweden)

    Frederike Felcht

    2013-01-01

    Full Text Available According to recent research in literary studies, literature has a specific knowledge about things. My contribution supports this thesis by analyzing the world of things in Hans Christian Andersen's fairy tales. Exemplary readings reveal how Andersen's texts acknowledge the power of things in modern life and how these texts thus question scientific and philosophical concepts of subjectivity that dominated in the nineteenth century. The agency of things in Andersen's texts challenges the ideal of a rational subject that acts autonomously. Current theoretical approaches, notably Actor-Network-Theory, allow us to understand the realism of acting things in Andersen's work. That which is marvelous, which is prevalently used to define the genre Fairy Tale in literary studies, is inherent to modernity. The relationship between magic and modernity is different than expected: modernity consists of an interplay between enchantment and disenchantment.

  15. Safe disposal of radioactive waste. Post-closure safety assessment of permanent repository in Novi han

    International Nuclear Information System (INIS)

    Mateeva, M.

    2007-01-01

    A presented material is the third part of the monograph with title 'Safe disposal of radioactive waste. Post-closure safety assessment of the permanent repository in Novi Han'. This part deals with review of the scenario selection procedure. The process system of permanent repository for radioactive waste is describing in details for different levels. Preliminary screening process of features, events and processes is presented here. Interaction matrixes for basic disposal system components are constructed. Final selection and grouping between the included features, events and processes is done. Selected and defined scenarios for post-closure safety assessment are presented too. Key words: post-closure safety assessment, scenario generation procedure, process system, process influence diagram, and interaction matrix

  16. The pursuit of happiness: The social and scientific origins of Hans Selye's natural philosophy of life.

    Science.gov (United States)

    Jackson, Mark

    2012-12-01

    In 1956, Hans Selye tentatively suggested that the scientific study of stress could 'help us to formulate a precise program of conduct' and 'teach us the wisdom to live a rich and meaningful life'. Nearly two decades later, Selye expanded this limited vision of social order into a full-blown philosophy of life. In Stress without Distress , first published in 1974, he proposed an ethical code of conduct designed to mitigate personal and social problems. Basing his arguments on contemporary understandings of the biological processes involved in stress reactions, Selye referred to this code as 'altruistic egotism'. This article explores the origins and evolution of Selye's 'natural philosophy of life', analysing the links between his theories and adjacent intellectual developments in biology, psychosomatic and psychosocial medicine, cybernetics and socio-biology, and situating his work in the broader cultural framework of modern western societies.

  17. [Hans Gross as an archaeologist--the significance of archaeology for 'encyclopedic' criminology].

    Science.gov (United States)

    Karl, Stephan; Bachhiesl, Christian

    2014-01-01

    In some cases, forensics and criminology have to cooperate with disciplines that usually are counted among the humanities, e.g. with archaeology. This article examines the significance of this cooperation for the criminological epistemology at the turn of the 19th century. These methodological considerations are illustrated by an example: When Hans Gross, who became the founder of the Austrian School of Criminology later, saw an unusually shaped hill near Feldbach, a town in southern Styria, he assumed this hill to be a burial mound and informed the responsible archaeological authorities immediately. Further investigations showed, however, that this hill was a natural formation. This is an early example for interdisciplinary cooperation, which proves that both in archaeology and in criminology a thorough inspection of the site is decisive for further scientific analysis of the topic of research.

  18. ALBERT, HANS, Racionalismo crítico. Por Juan A. Estrada

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    Juan A. Estrada

    2013-06-01

    Full Text Available Autor: Hans Albert (2002 Editorial: Síntesis, Madrid, 238 pp.   Desde su tratado sobre la razón crítica, Albert no ha cesado de precisar su concepción filosófica, desde un diálogo constante con Popper y respondiendo a las diversas críticas de la hermenéutica y la fenomenología, de la teoría crítica y de la misma teología. En este volumen ofrece varios trabajos con el subtítulo de «Cuatro capítulos para una sátira del pensamiento ilusorio», precedida de un denso y buen prólogo de Ángeles J. Perona.

  19. Development of technical design for waste processing and storage facilities for Novi Han repository

    International Nuclear Information System (INIS)

    Canizares, J.; Benitez, J.C.; Asuar, O.; Yordanova, O.; Demireva, E.; Stefanova, I.

    2005-01-01

    Empresarion Agrupados Internacional S.A. (Spain) and ENPRO Consult Ltd. (Bulgaria) were awarded a contract by the Central Finance and Contracts Unit to develop the technical design of the waste processing and storage facilities at the Novi Han repository. At present conceptual design phase is finished. This conceptual design covers the definition of the basic design requirements to be applied to the installations defined above, following both European and Bulgarian legislation. In this paper the following items are considered: 1) Basic criteria for the layout and sizing of buildings; 2) Processing of radioactive waste, including: treatment and conditioning of disused sealed sources; treatment of liquid radioactive wastes; treatment of solid radioactive waste; conditioning of liquid and solid radioactive waste; 3) Control of waste packages and 4) Storage of radioactive waste, including storage facility and waste packages. An analysis of inventories of stored and estimated future wastes and its subsequent processes is also presented and the waste streams are illustrated

  20. Suicidal risk factors of recurrent major depression in Han Chinese women.

    Directory of Open Access Journals (Sweden)

    Yuzhang Zhu

    Full Text Available The relationship between suicidality and major depression is complex. Socio- demography, clinical features, comorbidity, clinical symptoms, and stressful life events are important factors influencing suicide in major depression, but these are not well defined. Thus, the aim of the present study was to assess the associations between the above-mentioned factors and suicide ideation, suicide plan, and suicide attempt in 6008 Han Chinese women with recurrent major depression (MD. Patients with any suicidality had significantly more MD symptoms, a significantly greater number of stressful life events, a positive family history of MD, a greater number of episodes, a significant experience of melancholia, and earlier age of onset. Comorbidity with dysthymia, generalized anxiety disorder (GAD, social phobia, and animal phobia was seen in suicidal patients. The present findings indicate that specific factors act to increase the likelihood of suicide in MD. Our results may help improve the clinical assessment of suicide risk in depressed patients, especially for women.

  1. Pure Theory of Hans Kelsen and Criticism of Luis Alberto Warat

    Directory of Open Access Journals (Sweden)

    Thaisa Haber Faleiros

    2015-12-01

    building a new model for learning practices based on a remaking of old premises according to a critical and reflexive law, Warat aims at preventing law knowledge from being mummified and completely adapted to renewable and ceaseless situations and conflicts because of lack of critical reasoning. To contextualize this authors approach, this study presents previously the positivist theory of law, whose exponent is Hans Kelsen. After all, studying Warat means verifying the ways he followed to reach his approach. Besides, delaing with law teaching requires tracing back its legislation since its creation in 1827 to the present. For that, Kelsen laws pure theory, its influence on law teaching and Warat ideas on law and his pedagogical approach are unfolded in the context of law teaching history.

  2. Forensic characteristics and phylogenetic analysis of Hubei Han population in central China using 17 Y-STR loci.

    Science.gov (United States)

    Wang, Zheng; Du, Weian; He, Guanglin; Liu, Jing; Hou, Yiping

    2017-07-01

    Currently, the largest national database within the Y chromosome haplotype reference database (YHRD, https://yhrd.org, release 53) is China, which has approximately 38000 Y chromosomal 17-marker (Yfiler) haplotypes. These haplotype profiles derived from the vast majority of Chinese administrative divisions, but no haplotype data was available for Hubei province, which is located in the Central China region. Herein, 429 unrelated male Chinese Han individuals residing in Hubei province were recruited and genotyped with 17 Y-STR loci. 115 alleles were identified with corresponding allele frequencies spanned from 0.0023 to 07506. The gene diversity (GD) values ranged from 0.3988 at DYS438 to 0.9573 at DYS385a/b. A total of 410 distinct haplotypes were obtained with the overall haplotype diversity (HD) and discrimination capacity (DC) was 0.9995 and 0.9557, respectively. Additionally, genetic relationships along administrative (Han Chinese from different provinces) and ethnic divisions (minority ethnic groups) were analyzed using analysis of molecular variance (AMOVA) tests and visualized by multidimensional scaling plots (MDS). The Han ethnicity including the Hubei Han shows a high genetic homogeneity all across China and significant genetic differences existed between the Hubei Han and some ethnic groups, most prominently for the Kazakhs and the Tibetans. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. The relationship between hemoglobin level and the type 1 diabetic nephropathy in Anhui Han's patients.

    Science.gov (United States)

    Jiang, Jun; Lei, Lan; Zhou, Xiaowan; Li, Peng; Wei, Ren

    2018-02-20

    Recent studies have shown that low hemoglobin (Hb) level promote the progression of chronic kidney disease. This study assessed the relationship between Hb level and type 1 diabetic nephropathy (DN) in Anhui Han's patients. There were a total of 236 patients diagnosed with type 1 diabetes mellitus and (T1DM) seen between January 2014 and December 2016 in our centre. Hemoglobin levels in patients with DN were compared with those without DN. The relationship between Hb level and the urinary albumin-creatinine ratio (ACR) was examined by Spearman's correlational analysis and multiple stepwise regression analysis. The binary logistic multivariate regression analysis was performed to analyze the correlated factors for type 1 DN, calculate the Odds Ratio (OR) and 95%confidence interval (CI). The predicting value of Hb level for DN was evaluated by area under receiver operation characteristic curve (AUROC) for discrimination and Hosmer-Lemeshow goodness-of-fit test for calibration. The average Hb levels in the DN group (116.1 ± 20.8 g/L) were significantly lower than the non-DN group (131.9 ± 14.4 g/L) , P levels were independently correlated with the urinary ACR in multiple stepwise regression analysis. The logistic multivariate regression analysis showed that the Hb level (OR: 0.936, 95% CI: 0.910 to 0.963, P level (Hb level for DN. The value of P was 0.593 in Hosmer-Lemeshow goodness-of-fit test. In Anhui Han's patients with T1DM, the Hb level is inversely correlated with urinary ACR and DN. This article is protected by copyright. All rights reserved.

  4. Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.

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    Mai-Juan Ma

    Full Text Available BACKGROUND: Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. Macrophage receptor with a collagenous structure (MARCO is essential components required for toll like receptor-signaling in macrophage response to Mycobacterium tuberculosis, which may contribute to tuberculosis risk. PRINCIPAL FINDINGS: To specifically investigated whether single nucleotide polymorphisms (SNPs in MARCO gene are associated with pulmonary tuberculosis in Chinese Han population. By selecting tagging SNPs in MARCO gene, 17 tag SNPs were identified and genotyped in 923 pulmonary tuberculosis patients and 1033 healthy control subjects using a hospital based case-control association study. Single-point and haplotype analysis revealed an association in intron and exon region of MARCO gene. One SNP (rs17009726 was associated with susceptibility to pulmonary tuberculosis, where the carriers of the G allele had a 1.65 fold (95% CI = 1.32-2.05, p(corrected = 9.27E-5 increased risk of pulmonary tuberculosis. Haplotype analysis revealed that haplotype GC containing G allele of 17009726 and haplotype TGCC (rs17795618T/A, rs1371562G/T, rs6761637T/C, rs2011839C/T were also associated with susceptibility to pulmonary tuberculosis (p(corrected = 0.0001 and 0.029, respectively. CONCLUSIONS: Our study suggested that genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population, and the findings emphasize the importance of MARCO mediated immune responses in the pathogenesis of tuberculosis.

  5. TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population

    Science.gov (United States)

    Liu, Lijun; Li, Jingjie; Yan, Mengdan; Li, Jing; Chen, Junyu; Zhang, Yi; Zhu, Xikai; Wang, Li; Kang, Longli; Yuan, Dongya; Jin, Tianbo

    2017-01-01

    Single nucleotide polymorphisms (SNPs) in TCF7L2 (Transcription Factor 7-Like 2) reportedly affect susceptibility to schizophrenia (SCZ). We examined the association between TCF7L2 polymorphisms and SCZ susceptibility in a Chinese Han population. Six SNPs were genotyped in 499 SCZ patients and 500 healthy individuals, after which their associations with SCZ were evaluated using the Chi-squared test and genetic model analyses. We observed that the allele A of rs12573128 is associated with an increased SCZ risk (odds ratio [OR] = 1.33, 95% confidence interval [CI]: 1.08-1.63, P = 0.006, adjusted P = 0.030). The AA genotype of rs12573128 was associated with a higher SCZ risk than the GG genotype, before and after adjustment for sex and age (adjusted OR = 2.97, 95% CI: 1.49-5.92, P = 0.002). In addition, SNP rs12573128 was associated with 1.47-fold, 2.64-fold and 1.50-fold increases in SCZ risk of in dominant, recessive and additive model, respectively (adjusted OR = 1.47, 95% CI = 1.09-1.99, P = 0.012; Bonferroni adjusted P = 0.030). adjusted OR = 2.64, 95% CI = 1.34-5.18, P = 0.005 and adjusted OR = 1.50, 95% CI = 1.17-1.93, P = 0.002, respectively). These results suggest rs12573128 is significantly associated with an increased risk of SCZ in the Chinese Han population. PMID:28404897

  6. Polymorphisms in CISH gene are associated with persistent hepatitis B virus infection in Han Chinese population.

    Science.gov (United States)

    Hu, Zhangyong; Yang, Jinliang; Wu, Yangping; Xiong, Guolian; Wang, Yali; Yang, Jun; Deng, Lan

    2014-01-01

    Cytokine-inducible SRC homology 2 domain protein (CISH) is the first member of the suppressors of cytokine signaling (SOCS) protein family. An association between multiple CISH polymorphisms and susceptibility to infectious diseases has been reported. This study aimed to investigate the possible association of these single nucleotide polymorphisms (SNPs) in CISH gene with different outcomes of Hepatitis B virus (HBV) infection. 1019 unrelated Chinese Han subjects, including 240 persistent asymptomatic HBV carriers, 217 chronic hepatitis B patients, 137 HBV-related liver cirrhosis patients, and 425 cases of spontaneously recovered HBV as controls, were studied. Four SNPs (rs622502, rs2239751, rs414171 and rs6768300) in CISH gene were genotyped with the snapshot technique. Transcriptional activity of the CISH promoter was assayed in vitro using the dual-luciferase reporter assay system. At position rs414171, A allele and AA genotype frequencies were significantly higher in the HBV-resolved group as compared to the persistent HBV infection group. At position rs2239751, TT genotype was further observed in the HBV-resolved group. Using asymptomatic HBV carriers as controls, our results indicated that the rs414171 and rs2239751 polymorphisms were unrelated to HBV progression. The other two SNPs (rs622502 and rs6768300) showed no association with persistent HBV infection. Haplotype analysis revealed that the GGCA haplotype was associated with spontaneous clearance of HBV in this population. Moreover, luciferase activity was significantly higher in the PGL3-Basic-rs414171T construct as compared to the PGL3-Basic-rs414171A construct (pCISH gene were associated with persistent HBV infection in Han Chinese population, but not with HBV progression.

  7. Polymorphisms in CISH gene are associated with persistent hepatitis B virus infection in Han Chinese population.

    Directory of Open Access Journals (Sweden)

    Zhangyong Hu

    Full Text Available BACKGROUND AND AIM: Cytokine-inducible SRC homology 2 domain protein (CISH is the first member of the suppressors of cytokine signaling (SOCS protein family. An association between multiple CISH polymorphisms and susceptibility to infectious diseases has been reported. This study aimed to investigate the possible association of these single nucleotide polymorphisms (SNPs in CISH gene with different outcomes of Hepatitis B virus (HBV infection. METHODS: 1019 unrelated Chinese Han subjects, including 240 persistent asymptomatic HBV carriers, 217 chronic hepatitis B patients, 137 HBV-related liver cirrhosis patients, and 425 cases of spontaneously recovered HBV as controls, were studied. Four SNPs (rs622502, rs2239751, rs414171 and rs6768300 in CISH gene were genotyped with the snapshot technique. Transcriptional activity of the CISH promoter was assayed in vitro using the dual-luciferase reporter assay system. RESULTS: At position rs414171, A allele and AA genotype frequencies were significantly higher in the HBV-resolved group as compared to the persistent HBV infection group. At position rs2239751, TT genotype was further observed in the HBV-resolved group. Using asymptomatic HBV carriers as controls, our results indicated that the rs414171 and rs2239751 polymorphisms were unrelated to HBV progression. The other two SNPs (rs622502 and rs6768300 showed no association with persistent HBV infection. Haplotype analysis revealed that the GGCA haplotype was associated with spontaneous clearance of HBV in this population. Moreover, luciferase activity was significantly higher in the PGL3-Basic-rs414171T construct as compared to the PGL3-Basic-rs414171A construct (p<0.001. CONCLUSION: Two SNPs (rs414171 and rs2239751 in the CISH gene were associated with persistent HBV infection in Han Chinese population, but not with HBV progression.

  8. Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population

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    Zhao Nan

    2012-07-01

    Full Text Available Abstract Background Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorphisms and their association with ischemic stroke in a Chinese Han population. Methods A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes. We tested the genotype-stroke association with logistic regression model. Results We found two single nucleotide polymorphisms (SNPs in CCL11 were associated with ischemic stroke. After adjusting for multiple testing using false discovery rate (FDR with a 0.20 cut-off point, CCL11 rs4795895 remained statistically significant. We further stratified the study population by their hypertension status. In the hypertensive group, CCR2 rs1799864, CCR5 rs1799987 and CCL11 rs4795895 were nominally associated with increased risk of stroke. In the non-hypertensive group, CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 and CCL11 rs4795895 were associated with ischemic stroke. After correction for multiple testing, CCR2 rs1799864 and CCR5 rs1799987 remained significant in the hypertensive group, and CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 remained significant in the non-hypertensive group. Conclusions Our results indicate that inflammatory genetic variants are associated with increased risk of ischemic stroke in a Chinese Han population, particularly in non-hypertensive individuals.

  9. Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population.

    Science.gov (United States)

    Zhao, Nan; Liu, Xin; Wang, Yongqin; Liu, Xiaoqiu; Li, Jiana; Yu, Litian; Ma, Liyuan; Wang, Shuyu; Zhang, Hongye; Liu, Lisheng; Zhao, Jingbo; Wang, Xingyu

    2012-07-06

    Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorphisms and their association with ischemic stroke in a Chinese Han population. A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes. We tested the genotype-stroke association with logistic regression model. We found two single nucleotide polymorphisms (SNPs) in CCL11 were associated with ischemic stroke. After adjusting for multiple testing using false discovery rate (FDR) with a 0.20 cut-off point, CCL11 rs4795895 remained statistically significant. We further stratified the study population by their hypertension status. In the hypertensive group, CCR2 rs1799864, CCR5 rs1799987 and CCL11 rs4795895 were nominally associated with increased risk of stroke. In the non-hypertensive group, CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 and CCL11 rs4795895 were associated with ischemic stroke. After correction for multiple testing, CCR2 rs1799864 and CCR5 rs1799987 remained significant in the hypertensive group, and CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 remained significant in the non-hypertensive group. Our results indicate that inflammatory genetic variants are associated with increased risk of ischemic stroke in a Chinese Han population, particularly in non-hypertensive individuals.

  10. La persona como singularidad concreta en la obra de Hans Urs von Balthasar

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    Anneliese Meis W.

    2001-01-01

    Full Text Available El presente estudio aborda el concepto de persona de Hans Urs von Balthasar en cuanto singularidad concreta, descubierto a través de una intensa lectura analítica de su voluminosa obra, búsqueda a la luz de la pregunta ¿por qué yo soy precisamente yo? En efecto, el teólogo suizo nunca sistematiza su comprensión de persona ­la distingue sí de los conceptos "individuo", "sujeto" y "espíritu­, pese a que se sirve de aquella como de uno de los pilares más significativos de su pensamiento. Los resultados obtenidos evidencian la complejidad de factores conceptuales, que demuestran que el yo tiene su fundamento último en el acto libre del amor infinito, que como tal constituye la persona desde el dinamismo intradivino de las relaciones opuestas entre Padre, Hijo y Espíritu SantoThis paper regards the concept of person as a concrete singularity in Hans Urs Von Balthasar's work. Such concept rose after a deep analytical reading of his voluminous work, in the light of the guiding question; Why am I, precisely I? The Swiss theologian distinguishes person from the concepts "individual", "subject" and "spirit", but he never synthesises his understanding of person, even though he uses it as one of the most significant pillars of his thought. The results obtained from the research confirm the complexity of the conceptual factors, which show that one's self has its deepest foundation in the free act of the infinite love, which as such, constitutes the person from the intra-divine dynamism of the opposed relations between the Father, Son and Holy Spirit

  11. Role of IL-17 Variants in Preeclampsia in Chinese Han Women.

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    Haiyan Wang

    Full Text Available Previous studies have suggested an important role for IL-17, mainly secreted by Th17 cells, in the development of systemic inflammation in preeclampsia (PE. This study therefore investigated the association between genetic variants in IL-17A, IL-17F, and IL-17RA and susceptibility to PE in Chinese Han women. We recruited 1,031 PE patients and 1,298 controls of later pregnant women, and used TaqMan allelic discrimination real-time PCR to genotype the polymorphisms of IL17A rs2275913, IL-17F rs763780, and IL-17RA rs4819554. No significant differences in genotypic or allelic frequencies were found at all three polymorphic sites between PE patients and controls (rs2275913: genotype χ2 = 0.218, p = 0.897 and allele χ2 = 0.157, p = 0.692, OR = 1.024, 95%CI 0.911-1.152; rs763780: genotype χ2 = 1.948, p = 0.377 and allele χ2 = 1.242, p = 0.265, OR = 0.897, 95%CI 0.741-1.086; rs4819554: genotype χ2 = 0.633, p = 0.729 and allele χ2 = 0.115, p = 0.735, OR = 1.020, 95%CI 0.908-1.146. There were also no significant differences in genetic distributions between mild/severe PE or early/late-onset PE and control subgroups. Our data indicate that the genetic variants of rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA may not play a role in the pathogenesis of PE in Chinese Han women. However, these findings should be confirmed in other ethnic populations.

  12. [Hans Neuffer (1892-1968). Medical moral philosopher and politician of profession in personal union].

    Science.gov (United States)

    Denis, Réne; Gross, Dominik

    2003-01-01

    Hans Neuffer had a well established, civil familiary background. He was raised according to Christian values and remained a practising Christian until the end of his life. Before 1945 he was no person in public life. In spite of the fact that he disapproved the Nazi rule, he did not practise open resistance. After World War Two politically guiltless physicians were needed. Neuffer had this quality and on top of that he had a talent for organisation. In the beginning he was medical functionary in his swabian hometown Stuttgart. In 1949 he took over tasks as medical functionary nationwide. Under his leadership the German physicians succeeded in creating the structures of self administration, that still exist today. Big improvements in income were achieved. The German physicians profited from this until the seventy years of the last century. In addition to this the German doctors managed to become fully accepted members of the World Medical Association (WMA). Besides his work as medical functionary, Neuffer was occupied with ethical questions. The premise of Neuffer's medical ethics were the physician's close ties to God. The responsibility to God was more important than responsibility to conscience, science, the people or the government. One of the foundations of Neuffer's ethics lies in the doctor's personality. Like an artist the "true" physician felt an inner calling. He possessed high mental capacity and had special psychological abilities. Such high moral, mental and psychological demands could only be fulfilled in freedom. Freedom required an adequate income and physicians' self administration. This kind of medical ethics fitted well to the political aims of West Germany's General Medical Council. The freedom of the medical profession and independence from society or government were crucial positions. Hans Neuffer was a politically and morally guiltless medical functionary. At the end of his presidency in 1959, West Germany's physicians had achieved all

  13. Association Study between Ghrelin Gene Polymorphism and Metabolic Syndrome in a Han Chinese Population.

    Science.gov (United States)

    You, Yueyue; Yu, Yaqin; Wu, Yanhua; Rao, Wenwang; Zhang, Yangyu; Liu, Yingyu; Yang, Guang; Fu, Yingli; Shi, Jieping; Kou, Changgui

    2017-01-01

    Ghrelin, in humans, is a hormone secreted from the stomach with an orexigenic effect, which is good for digestion and absorption, as well as regulating physical growth, metabolism, and energy balance. It is also involved in the development of metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). This study assessed the association between single nucleotide variants of the GHRL gene and the risk of metabolic syndrome in a Han Chinese population. A case-control study was performed on 3780 Han Chinese comprising 1813 MetS cases and 1967 controls. Three missense polymorphisms in GHRL (rs26802, rs10490816, and rs696217) were selected, and the association between these polymorphisms and the risk of MetS was investigated. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). Using Pearson's 2 test, we found that there were no significant differences in genotype distributions and allele frequencies between cases and controls (all p > 0.05). There were also no significant differences in haplotype distributions between MetS cases and healthy controls. Furthermore, we confirmed that rs26802 of the GHRL gene is associated with body mass index (BMI), waist circumference, systolic blood pressure (SBP), and fasting glucose; rs10490816 is associated with triglycerides (TG) and total cholesterol (TC); while rs696217 is associated with hip circumference and fasting glucose. We concluded that mutations in the GHRL gene did not confer risk for MetS in our study population. Therefore, functional analysis and replication studies in other populations are needed to further investigate the exact role of the GHRL gene in MetS.

  14. Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population.

    Science.gov (United States)

    Wen, Zujia; Chen, Jianhua; Khan, Raja Amjad Waheed; Song, Zhijian; Wang, Meng; Li, Zhiqiang; Shen, Jiawei; Li, Wenjin; Shi, Yongyong

    2016-04-01

    Schizophrenia, major depressive disorder, and bipolar disorder are three major psychiatric disorders affecting around 0.66%, 3.3%, and 1.5% of the Han Chinese population respectively. Several genetic linkage analyses and genome wide association studies identified NRG1 as a susceptibility gene of schizophrenia, which was validated by its role in neurodevelopment, glutamate, and other neurotransmitter receptor expression regulation. To further investigate whether NRG1 is a shared risk gene for major depressive disorder, bipolar disorder as well as schizophrenia, we performed an association study among 1,248 schizophrenia cases, 1,056 major depression cases, 1,344 bipolar disorder cases, and 1,248 controls. Totally 15 tag SNPs were genotyped and analyzed, and no population stratification was found in our sample set. Among the sites, rs4236710 (corrected Pgenotye  = 0.015) and rs4512342 (Pallele  = 0.03, Pgenotye  = 0.045 after correction) were associated with schizophrenia, and rs2919375 (corrected Pgenotye  = 0.004) was associated with major depressive disorder. The haplotype rs4512342-rs6982890 showed association with schizophrenia (P = 0.03 for haplotype "TC" after correction), and haplotype rs4531002-rs11989919 proved to be a shared risk factor for both major depressive disorder ("CC": corrected P = 0.009) and bipolar disorder ("CT": corrected P = 0.003). Our results confirmed that NRG1 was a shared common susceptibility gene for major mental disorders in Han Chinese population. © 2016 Wiley Periodicals, Inc.

  15. An epidemiological survey of low back pain and axial spondyloarthritis in a Chinese Han population.

    Science.gov (United States)

    Liao, Z T; Pan, Y F; Huang, J L; Huang, F; Chi, W J; Zhang, K X; Lin, Z M; Wu, Y Q; He, W Z; Wu, J; Xie, X J; Huang, J X; Wei, Q J; Li, T W; Wu, Z; Yu, B Y; Gu, J R

    2009-01-01

    To investigate the prevalence of low back pain (LBP) and axial spondyloarthritis (SpA) in a Chinese Han population. A face-to-face investigation was performed in the Han population of Dalang Town, Yangshan County, Guangdong Province, China, using a questionnaire established in France in 1999. First the clinical features associated with SpA were investigated, then the human leucocyte antigen (HLA)-B27 and sacroiliac joint radiographic examinations were carried out. Finally, the diagnosis of SpA was determined by rheumatologists. A total of 13 315 subjects participated in the study and 10 921 were aged >16 years; of these, 787 (7.21%) had LBP. There were 92 axial SpA patients (0.782% in subjects >16 years old and 11.96% in subjects with LBP). There were 29 (0.253%) cases of ankylosing spondylitis (AS), 60 (0.507%) undifferentiated axial SpA (USpA), and three (0.022%) psoriatic arthritis (PsA). Patients in the SpA groups had higher percentages in onset 3 months compared with those in other LBP groups. Simultaneous symptoms associated with spondylitis, such as buttock pain, heel pain, psoriasis, and SpA family history, were more commonly present. Of the axial SpA patients, 82.67% were HLA-B27 positive, clearly a greater percentage than those (11.65%) in other LBP groups. The survey questionnaire for SpA in this study is useful for axial SpA screening in China. In southern China, the prevalence of LBP is 7.21%. The prevalence of axial SpA is 0.782%. USpA is the most common subtype of SpA, followed by AS.

  16. Genetic Analysis of IL-17 Gene Polymorphisms in Gout in a Male Chinese Han Population.

    Science.gov (United States)

    Zhou, Zheng; Li, Xinde; Li, Hua; Guo, Mingzhen; Liu, Shiguo; Li, Changgui

    2016-01-01

    Interleukin (IL)-17 is a proinflammatory cytokine mainly secreted by activated T helper 17 cells and involved in inflammatory immune responses. This study aimed to investigate the association between IL-17 variants as well as serum IL-17 levels with gout in male Chinese Han individuals. A total of 1,101 male gout patients and 1,239 ethic-matched controls were enrolled. Genetic distributions of three variants (rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA) were detected by real-time polymerase chain reaction using the Taqman probe method. The plasma concentrations of IL-17A and IL-17F were measured in 228 gout patients and 198 controls that came from above samples by an enzyme-linked immunosorbent assay. No significant differences were observed in the genetic distribution of these polymorphisms between cases and controls (rs2275913: χ2 = 0.15, p = 0.928 by genotype, χ2 = 0.14, p = 0.711 by allele; rs763780: χ2 = 2.24, p = 0.326 by genotype, χ2 = 0.26, p = 0.609 by allele; rs4819554: χ2 = 1.79, p = 0.409 by genotype, χ2 = 1.46, p = 0.227 by allele). Levels of serum IL-17A and IL-17F were significantly decreased in gout patients (both pgout patients between different genotypic carriers of rs2275913 and rs763780 regarding serum IL-17A and IL-17F levels (p>0.05). Although the genetic variants in IL-17 we studied in this research do not appear to be involved in the development of gout in male Chinese Han individuals, the IL-17 cytokine family may participate in gouty inflammation in an undefined way, which requires further validation.

  17. Disposition and kinetics of tetrabromobisphenol A in female Wistar Han rats

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    Gabriel A. Knudsen

    2014-01-01

    Full Text Available Tetrabromobisphenol A (TBBPA is the brominated flame retardant with the largest production volume worldwide. NTP 2-year bioassays found TBBPA dose-dependent increases in uterine tumors in female Wistar Han rats; evidence of reproductive tissues carcinogenicity was equivocal in male rats. To explain this apparent sex-dependence, the disposition and toxicokinetic profile of TBBPA were investigated using female Wistar Han rats, as no data were available for female rats. In these studies, the primary route of elimination following [14C]-TBBPA administration (25, 250 or 1000 mg/kg was in feces; recoveries in 72 h were 95.7 ± 3.5%, 94.3 ± 3.6% and 98.8 ± 2.2%, respectively (urine: 0.2–2%; tissues: <0.1. TBBPA was conjugated to mono-glucuronide and -sulfate metabolites and eliminated in the bile. Plasma toxicokinetic parameters for a 250 mg/kg dose were estimated based on free TBBPA, as determined by UV/radiometric-HPLC analyses. Oral dosing by gavage (250 mg/kg resulted in a rapid absorption of compound into the systemic circulation with an observed Cmax at 1.5 h post-dose followed by a prolonged terminal phase. TBBPA concentrations in plasma decreased rapidly after an IV dose (25 mg/kg followed by a long elimination phase. These results indicate low systemic bioavailability (F < 0.05, similar to previous reports using male rats. Elimination pathways appeared to become saturated leading to delayed excretion after a single oral administration of the highest dose (1000 mg/kg; no such saturation or delay was detected at lower doses. Chronic high exposures to TBBPA may result in competition for metabolism with endogenous substrates in extrahepatic tissues (e.g., SULT1E1 estrogen sulfation resulting in endocrine disruption.

  18. Sexual dimorphism of the mandible in a contemporary Chinese Han population.

    Science.gov (United States)

    Dong, Hongmei; Deng, Mohong; Wang, WenPeng; Zhang, Ji; Mu, Jiao; Zhu, Guanghui

    2015-10-01

    A present limitation of forensic anthropology practice in China is the lack of population-specific criteria on contemporary human skeletons. In this study, a sample of 203 maxillofacial Cone beam computed tomography (CBCT) images, including 96 male and 107 female cases (20-65 years old), was analyzed to explore mandible sexual dimorphism in a population of contemporary adult Han Chinese to investigate the potential use of the mandible as sex indicator. A three-dimensional image from mandible CBCT scans was reconstructed using the SimPlant Pro 11.40 software. Nine linear and two angular parameters were measured. Discriminant function analysis (DFA) and logistic regression analysis (LRA) were used to develop the mathematics models for sex determination. All of the linear measurements studied and one angular measurement were found to be sexually dimorphic, with the maximum mandibular length and bi-condylar breadth being the most dimorphic by univariate DFA and LRA respectively. The cross-validated sex allocation accuracies on multivariate were ranged from 84.2% (direct DFA), 83.5% (direct LRA), 83.3% (stepwise DFA) to 80.5% (stepwise LRA). In general, multivariate DFA yielded a higher accuracy and LRA obtained a lower sex bias, and therefore both DFA and LRA had their own advantages for sex determination by the mandible in this sample. These results suggest that the mandible expresses sexual dimorphism in the contemporary adult Han Chinese population, indicating an excellent sexual discriminatory ability. Cone beam computed tomography scanning can be used as alternative source for contemporary osteometric techniques. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  19. Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population.

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    Po-Hsiu Kuo

    Full Text Available Autism spectrum disorder (ASD is a neurodevelopmental disorder with strong genetic components. Several recent genome-wide association (GWA studies in Caucasian samples have reported a number of gene regions and loci correlated with the risk of ASD--albeit with very little consensus across studies.A two-stage GWA study was employed to identify common genetic variants for ASD in the Taiwanese Han population. The discovery stage included 315 patients with ASD and 1,115 healthy controls, using the Affymetrix SNP array 6.0 platform for genotyping. Several gene regions were then selected for fine-mapping and top markers were examined in extended samples. Single marker, haplotype, gene-based, and pathway analyses were conducted for associations.Seven SNPs had p-values ranging from 3.4~9.9*10-6, but none reached the genome-wide significant level. Five of them were mapped to three known genes (OR2M4, STYK1, and MNT with significant empirical gene-based p-values in OR2M4 (p = 3.4*10(-5 and MNT (p = 0.0008. Results of the fine-mapping study showed single-marker associations in the GLIS1 (rs12082358 and rs12080993 and NAALADL2 (rs3914502 and rs2222447 genes, and gene-based associations for the OR2M3-OR2T5 (olfactory receptor genes, p = 0.02, and GLIPR1/KRR1 gene regions (p = 0.015. Pathway analyses revealed important pathways for ASD, such as olfactory and G protein-coupled receptors signaling pathways.We reported Taiwanese Han specific susceptibility genes and variants for ASD. However, further replication in other Asian populations is warranted to validate our findings. Investigation in the biological functions of our reported genetic variants might also allow for better understanding on the underlying pathogenesis of autism.

  20. Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population

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    Ding YP

    2017-03-01

    Full Text Available Yipeng Ding,* Heping Xu,* Jinjian Yao, Dongchuan Xu, Ping He, Shengyang Yi, Quanni Li, Yuanshui Liu, Cibing Wu, Zhongjie Tian Department of Emergency, People’s Hospital of Hainan Province, Haikou, Hainan, People’s Republic of China *These authors contributed equally to this work Objective: We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 (RTEL1, which has been associated with telom­ere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD in a Chinese Han population.Methods: In a case–control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms in RTEL1 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs and 95% confidence intervals (CIs were calculated using unconditional logistic regression after adjusting for age and gender.Results: In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10–0.82; P=0.02. In the genetic model analysis, we found that the “C/C” genotype of rs4809324 was associated with a decreased risk of COPD based on the codominant model (OR =0.33; 95% CI =0.13–0.86; P=0.022 and recessive model (OR =0.32; 95% CI =0.12–0.80; P=0.009.Conclusion: Our data shed new light on the association between genetic polymorphisms of RTEL1 and COPD susceptibility in the Chinese Han population. Keywords: RTEL1, chronic obstructive pulmonary disease, COPD, gene polymorphisms, association study, case-control study

  1. Genetic polymorphism of Malassezia furfur isolates from Han and Tibetan ethnic groups in China using DNA fingerprinting.

    Science.gov (United States)

    Zhang, Hao; Zhang, Ruifeng; Ran, Yuping; Dai, Yaling; Lu, Yao; Wang, Peng

    2010-12-01

    Reported isolation rates of Malassezia yeast from human skin show geographic variations. In China, the populations of the Han (1,182.95 million) and Tibetan (5.41 million) ethnic groups are distributed over 9.6 and 3.27 million square kilometers respectively, making biodiversity research feasible and convenient. Malassezia furfur clinical strains (n = 29) isolated from different individuals, with or without associated dermatoses, of these two ethnic groups (15 Han and 12 Tibetan) were identified and analyzed with DNA fingerprinting using single primers specific to minisatellites. Using the Bionumerics software, we found that almost all M. furfur clinical isolates and type strains formed five distinct group clusters according to their associated skin diseases and the ethnic groups of the patients. These findings are the first to focus on the genetic diversity and relatedness of M. furfur in the Tibetan and Han ethnic groups in China and reveal genetic variation associated with related diseases, host ethnicity and geographic origin.

  2. Influence of the South-North Water Diversion Project and the mitigation projects on the water quality of Han River.

    Science.gov (United States)

    Zhu, Y P; Zhang, H P; Chen, L; Zhao, J F

    2008-11-15

    Situated in the central part of China, the Han River Basin is undergoing rapid social and economic development with some human interventions to be made soon which will profoundly influence the water environment of the basin. The integrated MIKE 11 model system comprising of a rainfall-runoff model (NAM), a non-point load evaluation model (LOAD), a hydrodynamic model (MIKE 11 HD) and a water quality model (ECOLab) was applied to investigate the impact of the Middle Route of the South-North Water Diversion Project on the Han River and the effectiveness of the 2 proposed mitigation projects, the 22 wastewater treatment plants (WWTPs) and the Yangtze-Han Water Diversion Project. The study concludes that business as usual will lead to a continuing rapid deterioration of the water quality of the Han River. Implementation of the Middle Route of the South-North Water Diversion Project in 2010 will bring disastrous consequence in the form of the remarkably elevated pollution level and high risk of algae bloom in the middle and lower reaches. The proposed WWTPs will merely lower the pollution level in the reach by around 10%, while the Yangtze-Han Water Diversion Project can significantly improve the water quality in the downstream 200-km reach. The results reveal that serious water quality problem will emerge in the middle reach between Xiangfan and Qianjiang in the future. Implementation of the South-North Water Diversion Project (phase II) in 2030 will further exacerbate the problem. In order to effectively improve the water quality of the Han River, it is suggested that nutrient removal processes should be adopted in the proposed WWTPs, and the pollution load from the non-point sources, especially the load from the upstream Henan Province, should be effectively controlled.

  3. An EPAS1 haplotype is associated with high altitude polycythemia in male Han Chinese at the Qinghai-Tibetan plateau.

    Science.gov (United States)

    Chen, Yu; Jiang, Chunhua; Luo, Yongjun; Liu, Fuyu; Gao, Yuqi

    2014-12-01

    Hemoglobin concentration at high altitude is considered an important marker of high altitude adaptation, and native Tibetans in the Qinghai-Tibetan plateau show lower hemoglobin concentrations than Han people who have emigrated from plains areas. Genetic studies revealed that EPAS1 plays a key role in high altitude adaptation and is associated with the low hemoglobin concentration in Tibetans. Three single nucleotide polymorphisms (rs13419896, rs4953354, rs1868092) of noncoding regions in EPAS1 exhibited significantly different allele frequencies in the Tibetan and Han populations and were associated with low hemoglobin concentrations in Tibetans. To explore the hereditary basis of high altitude polycythemia (HAPC) and investigate the association between EPAS1 and HAPC in the Han population, these 3 single nucleotide polymorphisms were assessed in 318 male Han Chinese HAPC patients and 316 control subjects. Genotyping was performed by high resolution melting curve analysis. The G-G-G haplotype of rs13419896, rs4953354, and rs1868092 was significantly more frequent in HAPC patients than in control subjects, whereas no differences in the allele or genotype frequencies of the 3 single nucleotide polymorphisms were found between HAPC patients and control subjects. Moreover, genotypes of rs1868092 (AA) and rs4953354 (GG) that were not observed in the Chinese Han in the Beijing population were found at frequencies of 1.6% and 0.9%, respectively, in our study population of HAPC patients and control subjects. Carriers of this EPAS1 haplotype (G-G-G, rs13419896, rs4953354, and rs1868092) may have a higher risk for HAPC. These results may contribute to a better understanding of the pathogenesis of HAPC in the Han population. Copyright © 2014 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

  4. Nietzsche se uitspraak God-is-dood, en die interpretasievoorstelle van Hans Küng en Jürgen Moltmann

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    A. J. Groenewald

    1998-12-01

    Full Text Available Nietzsche's theorem 'God-is-dead' and the reading models of HansKüng and Jürgen Moltmann. In this article the meaning and significance of Nietzsche's theorem 'God-is-dead' is examined. Through the reading models of Hans Küng and Jürgen Moltmann, an atempt is made to indicate that Nietzsche did not per se acknowledged or denied the existence of God. These reading models, although different, eliminate vaious theological misunderstandings and misinterpretations. This is important for the current theological debate.

  5. Genetic mutations in non-syndromic deafness patients of uyghur and han chinese ethnicities in xinjiang, China: a comparative study

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    Kuyaxi Pilidong

    2011-09-01

    Full Text Available Abstract Background The deafness-associated gene mutation profile varies greatly among regions and races. Due to the multi-ethnic coalition of over one thousand years, non-syndromic deafness (NSD patients of Uyghur ethnicity may exhibit a unique deafness-associated gene mutation spectrum as compared to Han Chinese deaf population. Methods In order to characterize nine loci of four deafness-associated genes of Uyghur NSD patients in comparison with Chinese Han deaf population, NSD patients (n = 350 were enrolled, including Uyghur (n = 199 and Han Chinese (n = 151. Following the history taking, blood samples were collected for DNA extraction. DNA microarray was performed on nine loci of four deafness-associated genes, including 35delG, 176-191del16, 235delC, 299-300delAT, 538C > T, 1555A > G, 1494C > T, 2168A > G, and IVS7-2A > G. The samples that showed the absence of both wild and mutant probe signals were tested for further DNA sequencing analysis. Results The mutations in the nine loci of prevalent deafness-associated genes were detected in 13.06% of Uyghur NSD patients and 32.45% of Han Chinese patients (P GJB2 mutation was detected in 9.05% of Uyghur patients and 16.56% of Han Chinese patients (P > 0.05, respectively. 235delC was the hotspot mutation region in NSD patients of the two ethnicities, whereas 35delG was the mutation hotspot in Uyghur patients. 187delG mutation was detected for the first time in Uyghur NSD patients and considered as an unreported pathological variant of GJB2. SLC26A4 mutation was found in 2.01% of Uyghur patients and 14.57% of Han Chinese patients (P P > 0.05, respectively. The NSD patients exhibited a low frequency of GJB3 mutation regardless of ethnicity. Conclusion Prevalent deafness-associated gene mutations in the nine loci studied were less frequently detected in Uyghur NSD patients than in Han Chinese patients. GJB2 was the most common mutant gene in the two ethnicities, whilst the two ethnicities differed

  6. Trump har droppet fløjlshandskerne, nu da han er slået tilbage til start

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella

    2016-01-01

    Donald Trump vandt primærvalget ved hjælp af personangreb. I præsidentvalgkampens slutspurt har han nu taget den strategi op igen, selvom alle dømte den ude – og det er måske slet ikke så dumt, for det er det, Trump kan......Donald Trump vandt primærvalget ved hjælp af personangreb. I præsidentvalgkampens slutspurt har han nu taget den strategi op igen, selvom alle dømte den ude – og det er måske slet ikke så dumt, for det er det, Trump kan...

  7. Eesti Vabariigi põhiseadus : kommenteeritud väljaanne / toimetuskolleegium: Eerik-Juhan Truuväli, Oliver Kask, Lasse Lehis, Heiki Lindpere, Uno Lõhmus, Ülle Madise, Kalle Merusk, Raul Narits, Vallo Olle, Jüri Põld, Heinrich Schneider

    Index Scriptorium Estoniae

    2002-01-01

    Kommentaaride autorid ja sisu: Sissejuhatus / Raul Narits, Heinrich Schneider, Lauri Madise. [Preambul] / Heinrich Schneider. I ptk. / Kalle Merusk, Taavi Annus, Madis Ernits, Heiki Lindpere, Lauri Madise. II ptk. / Uno Lõhmus, Taavi Annus, Madis Ernits, Oliver Kask, Eerik Kergandberg, Rait Maruste, Peeter Roosma. III ptk. / Oliver Kask. IV ptk. / Jüri Põld, Lauri Madise, Aaro Mõttus. V ptk. / Eerik-Juhan Truuväli, Ülle Madise, Jüri Põld, Urmas Reinsalu. VI ptk. / Kalle Merusk, Jüri Põld. VII ptk. / Eerik-Juhan Truuväli, Jüri Põld. VIII ptk. / Lasse Lehis. IX ptk. / Heiki Lindpere, Kristi Land, Lauri Madise, Heiki Pisuke. X ptk. / Oliver Kask, Enn Markvart, Jüri Põld. XI ptk. / Heinrich Schneider. XII ptk. / Raul Narits, Aare Reenumägi, Peeter Roosma, Enn Markvart. XIII ptk. / Uno Lõhmus, Madis Ernits, Jüri Põld. XIV ptk. / Vallo Olle, Arno Almann, Ülle Madise, Jüri Liventaal. XV ptk. / Eerik-Juhan Truuväli, Aaro Mõttus. Eesti Vabariigi põhiseaduse rakendamise seadus / Raul Narits, Peeter Roosma, Oliver Kask. Märksõnastik / koost. Ülle Madise, Peep Pruks. Kasutatud õigusaktide lühendid / koost. Virgo Saarmets. Eesti Vabariigi põhiseadus 1990-2002 : bibliograafia / koost. Maia Ruttu

  8. Genetic association between selected cytokine genes and glioblastoma in the Han Chinese population

    International Nuclear Information System (INIS)

    Jin, Tianbo; Li, Xiaolan; Zhang, Jiayi; Wang, Hong; Geng, Tingting; Li, Gang; Gao, Guodong; Chen, Chao

    2013-01-01

    Glioblastoma (GBM) is the most malignant brain tumor. Many abnormal secretion and expression of cytokines have been found in GBM, initially speculated that the occurrence of GBM may be involved in these abnormal secretion of cytokines. This study aims to detect the association of cytokine genes with GBM. We selected seven tag single nucleotide polymorphisms (tSNPs) in six cytokine genes, which previously reported to be associated with brain tumors, and analyzed their association with GBM in a Han Chinese population using χ 2 test and genetic model analysis. We found two risk tSNPs and one protective tSNP. By χ 2 test, the rs1801275 in IL-4R showed an increased risk of GBM. In the genetic model analysis, the genotype “TC” of rs20541 in IL-13 gene showed an increased risk of GBM in over-dominant model (OR = 2.00; 95% CI, 1.13-3.54, p = 0.015); the genotype “CT” of rs1800871 in the IL-10 gene showed a decrease risk in the over-dominant model (OR = 0.57; 95% CI, 0.33 – 0.97; p = 0.037). The genotype “AG” of rs1801275 in the IL-4R gene showed an increase risk in over-dominant model (OR = 2.29; 95% CI, 1.20 - 4.35; p = 0.0081) We further analyzed whether the six cytokine genes have a different effect on the disease in gender specific population, and found that the allele “G” of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 - 0.94, p = 0.0032), but the allele “T” showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 - 0.53, p = 0.0032). Our findings, combined with previously reported results, suggest that cytokine genes have potential role in GBM development, which may be useful to early prognostics for GBM in the Han Chinese population

  9. Maps of Relocation and Poems of Tang Dynasty Poets: Li Bai, Du Fu, and Han Yu

    Directory of Open Access Journals (Sweden)

    羅鳳珠、白璧玲、廖泫銘、范毅軍 、鄭錦全 Feng-Ju Lo,Pi-Ling Pai,Hsiung-Ming Liao,I-Chun Fan,Chin-Chuan Cheng

    2014-04-01

    Full Text Available Geographic environments affect literary contents and genre and thus, since ancient times, geographical area has been used to classify Chinese literature. In 1936 Liang Qichao was keenly aware of the relationship between literature and geography and brought up the idea of “literarygeography”. In 1979 Professor Chen Zhengxiang produced maps of birthplaces of Tang and Song poets to show the shift of Chinese cultural center from north to south. Furthermore, in the pastdecade, the attention to research in literary geography and geographical distribution of writersgradually increased. However, most studies focused on geographical distribution of birthplaces of writers and very few focused on the relationship between poets’ journey and the contents of their writings and their geographic environment. Meanwhile, geographic information system and aerialphotography have developed quickly and have become useful tools for the study of literary geography.Since then, the academic circles in Taiwan have built a solid foundation in this area. While Li Baiand Du Fu were called poetic immortal and poetic sage of the middle and end periods of the heydayof Tang Dynasty, respectively, Han Yu advocated the classical Chinese movement and becameone of the eight great authors of Tang and Song dynasties. Han Yu was also the best representative of Middle Tang poets. While the styles of these three poets differed from each other, they held key positions in the development and evolution of Tang poetry. Their footprints spread all over the countryand greatly affected later developments and contemporary of poetry. This project makes use of the digital Tang Dynasty maps by Tan Qixiang, Tang Dynasty transportation route maps by Yan Gengwang,aerial maps, the All Tang Poems, and chronicles of the poets to build the three poets’ relocation maps and study their poetic literature, language, geography, and interactions with others, in hopesof opening a new research direction

  10. Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population

    International Nuclear Information System (INIS)

    Wang, Lihong; Li, Dalin; Fu, Zhenkun; Li, Heng; Jiang, Wei; Li, Dianjun

    2007-01-01

    The host immunogenetic background plays an important role in the development of breast cancer. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a molecule expressed predominantly on activated T cells and is important during the down-regulation of T-cell activation. To evaluate the potential influences of CTLA-4 gene polymorphisms on breast cancer risk, a case-control study was conducted in Han women of Northeast China. We genotyped CTLA-4 variants (-1661 G/A, -658 T/C, -318 T/C, +49 G/A and CT60 G/A) to tag all common haplotypes (≥ 1% frequency) in 117 Chinese breast cancer cases and 148 age/sex matched healthy individuals. Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Data was analyzed using the Chi-square test and Haploview software. The frequency of CTLA-4 -1661G allele, -318T allele and CT60G allele carriers was significantly higher in patients than in controls (P = 0.0057, OR 1.91, 95% CI 1.21–3.02; P = 0.0031, OR 2.39, 95% CI 1.34–4.27; P = 0.023, OR 1.52, 95% CI 1.06–2.17, respectively). The -658T allele carrier frequency was significantly lower than in controls (P = 0.0000082, OR 0.17, 95% CI 0.08–0.37), whereas the +49A allele was significantly associated with tumor size in patients (P = 0.0033). Two common CTLA-4 haplotypes, ATCGA and ATCAG, were higher in healthy controls than patients (P = 0.0026, OR 0.17, 95% CI 0.05–0.54; P = 0.034, OR 0.12, 95% CI 0.02–0.92, respectively). A strong association was observed between tumor size and the ACCAA, ACCAG and ACCGA haplotypes (P = 0.0032, P = 0.0000031 and P = 0.017). These results suggest that polymorphisms of the CTLA-4 gene may modify individual susceptibility to and progression of breast cancer in Chinese Han women

  11. Association study of sepiapterin reductase gene promoter polymorphisms with schizophrenia in a Han Chinese population

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    Fu JW

    2015-10-01

    Full Text Available Jiawu Fu,1,* Guoda Ma,1,* Hui Mai,1,* Xudong Luo,2 Jingwen Yin,2 Qing Chen,2 Zhixiong Lin,2 Hua Tao,1 You Li,1 Lili Cui,1 Zheng Li,3 Juda Lin,2 Bin Zhao,1 Keshen Li1 1Institute of Neurology, Affiliated Hospital of Guangdong Medical University, 2Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People’s Republic of China; 3Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA *These authors contributed equally to this work Abstract: Sepiapterin reductase participates in the biosynthesis of tetrahydrobiopterin, which plays very important roles in the pathogenesis of schizophrenia via dysregulation of ­neurotransmitter systems. Here, two single nucleotide polymorphisms (rs1876487 and rs2421095 in the promoter region of SPR were genotyped in 941 schizophrenic patients and 944 controls in a Han Chinese population using the SNaPshot technique. No significant differences were found in the distribution of alleles or genotypes of the two single nucleotide polymorphisms (SNPs between schizophrenic patients and controls (all P>0.05. Likewise, no haplotype was found to be associated with schizophrenia. However, sex-stratified analysis revealed that the frequencies of the A allele of rs1876487 and the A–A (rs2421095–rs1876487 haplotype were all significantly different between schizophrenia and controls in females (P=0.040 and P=0.033, respectively, but not in males. Additionally, luciferase reporter gene assays revealed that the A–A haplotype had significantly higher SPR transcriptional activity compared with the A–C haplotype in SH-SY5Y cells. Our data indicate that the two SNPs do not influence the risk of schizophrenia when using the total sample, but the A allele of rs1876487 and the A–A haplotype may contribute to protective roles for schizophrenia in females. Keywords: schizophrenia, sepiapterin reductase, polymorphisms, Han

  12. Compositional Characteristics of Dissolved Organic Matter released from the sediment of Han river in Korea.

    Science.gov (United States)

    Oh, H.; Choi, J. H.

    2017-12-01

    The dissolved organic matter (DOM) has variable characteristics depending on the sources. The DOM of a river is affected by rain water, windborne material, surface and groundwater flow, and sediments. In particular, sediments are sources and sinks of nutrients and pollutants in aquatic ecosystems by supplying large amounts of organic matter. The DOM which absorbs ultraviolet and visible light is called colored dissolved organic matter (CDOM). CDOM is responsible for the optical properties of natural waters in several biogeochemical and photochemical processes and absorbs UV-A (315-400 nm) and UV-B (280-315), which are harmful to aquatic ecosystems (Helms et al., 2008). In this study, we investigated the quantity and quality of DOM and CDOM released from the sediments of Han river which was impacted by anthropogenic activities and hydrologic alternation of 4 Major River Restoration Project. The target area of this study is Gangchenbo (GC), Yeojubo (YJ), and Ipobo(IP) of the Han River, Korea. Sediments and water samples were taken on July and August of 2016 and were incubated at 20° up to 7 days. Absorbance was measured with UV-visible spectrophotometer (Libra S32 PC, Biochrom). Fluorescence intensity determined with Fluorescence EEMs (F-7000, Hitachi). Absorbance and fluorescence intensity were used to calculate Specific Ultraviolet Absorbance (SUVA254), Humification index (HIX), Biological index (BIX), Spectral slope (SR) and component analysis. The DOC concentration increased after 3 days of incubation. According to the SUVA254 analysis, the microbial activity is highest in the initial overlying water of IP. HIX have range of 1.35-4.08, and decrease poly aromatic structures of organic matter during incubation. From the results of the BIX, autochthonous organic matter was released from the sediments. In all sites, Humic-like DOM, Microbial humic-like DOM and Protein-like DOM increased significantly between Day 0 and 3(except Humic-like, Microbial humic-like DOM in

  13. [The disease and treatment of the frontline soldiers in Han dynasty].

    Science.gov (United States)

    Min, Hookie

    2015-04-01

    This paper purports to identify and analyze the medical information of the frontline soldiers in the Northwest borderland provinces of Han Dynasty, especially Juyan and Dunhuang region, through an heuristic reading of the Juyan Bamboo Slips and the Dunhuang Bamboo Slips of the Han Dynasty. My findings are as follows. The most frequent disease found in the bamboo slips was the external injury. The injury of the frontline soldiers mainly occurred from the quarrels among armed soldiers using weapons. The bamboo slips also demonstrate that the quarrels usually arose due to the fierce tension caused by the frontier line service such as heavy guard activity and labour duty. Undernourishment and chronic stress the soldiers suffered might be another reasons. The second most common disease harassing the soldiers was exogenous febrile disease. In most cases reviewed in this paper, the exogenous febrile disease was usually concurrent with complex symptoms such as chills, fever, headache, etc. The bamboo slips show that the exogenous febrile disease was related to the harsh climate of the Northwest provinces, featuring extremely dry weather and the large magnitude of diurnal temperature fluctuations. In addition, the annual temperature range in the Northwest province was huge, fluctuating between very cold and dry winter and very hot and dry summer. The third most common disease this study identified was the disorder of the digestive system and respiratory system. However, these two types of disease were virtually indistinguishable in the bamboo slips, because the ancient Chinese chroniclers did not distinguish them, usually dubbing both diseases simply 'abdominal pain.' It should be mentioned that a few slips mention contagious disease such as dysentery and dermatolosis, and sudden death, as well. Overall, the bamboo slips demonstrate extremely poor status of the soldiers' heath condition and poor medical environment surrounding the soldiers stationing in the Northwest

  14. Population data and phylogenetic structure of Han population from Jiangsu province of China on GlobalFiler STR loci.

    Science.gov (United States)

    Adnan, Atif; Zhan, Xiaoni; Kasim, Kadirya; Rakha, Allah; Xin, Xing Jia

    2018-03-02

    Forensic statistical parameters based on allelic frequencies of commonly used short tandem repeats were estimated for the Han population of Jiangsu province from P.R. China. The 6-dye GlobalFiler™ PCR amplification kit incorporates 21 autosomal STRs, providing reliable DNA typing results with enhanced the power of discrimination. Here, we analyzed the GlobalFiler™ STR loci in 516 unrelated individuals from Jiangsu Han population. A total of 256 alleles were observed ranging between 5 and 35.2 repeat units, and SE33 showed the greatest power of discrimination (34 alleles) in Jiangsu Han population. Most of the loci were found to be in the Hardy-Weinberg equilibrium after the Bonferroni correction with the exception of D3S1358. The combined power of exclusion (CPE) was 0.999999996353609, and the combined match probability (CMP) was 3.64 × 10 -25 . Phylogenetic parameters including pairwise genetic distances showed that Han population living in Jiangsu had closest genetic relationship with other East Asian populations. The present study provides precise reference database for forensic applications and population genetic studies.

  15. Multi-method study of the characteristic chemical nature of aquatic humic substances isolated from the Han River, Korea

    International Nuclear Information System (INIS)

    Kim, Hyun-Chul; Yu, Myong-Jin; Han, Ihnsup

    2006-01-01

    Natural organic matter (NOM) from the Han River, Korea was fractionated into humic and non-humic fractions by absorbing onto XAD-7HP, and these fractions were analyzed using UV-absorption, and for dissolved organic C (DOC). The humic fraction (i.e. humic substances; HS) was extracted and its characteristics were compared to commercial humic materials using various spectroscopic methods such as Fourier transform infrared (FT-IR), proton nuclear magnetic resonance ( 1 H-NMR) and fluorescence spectroscopy. The humic fraction as organic C was 47.0% on the average, however, a rainfall event brought a higher humic fraction into Han River water. The molar ratios of H/C and O/C in the HS from Han River water (HRHS) were 1.40 and 0.76, respectively, and the ratio of aliphatic to aromatic protons in the HS (P Al /P Ar ratio) was 5.8. Aromaticity and humification degree (i.e., degree of condensation) of HRHS were relatively lower than those from other humic materials, while the portion of oxygenated functional groups was relatively higher. FT-IR, 1 H-NMR and fluorescence spectroscopy showed distinct differences between HRHS and the commercial humic materials. Commercial humic materials are not representative of HS extracted from Han River water. The fluorescence spectra, relatively simple measurements, were found to be most useful as fingerprints for humic materials from particular sources

  16. PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome

    NARCIS (Netherlands)

    Meng, Q.L.; Liu, X.L.; Yang, P.Z.; Hou, S.P.; Du, L.P.; Zhou, H.Y.; Kijlstra, A.

    2009-01-01

    Purpose: To analyze the potential association of programmed cell death 1 (PDCD1) with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. Methods: Three single nucleotide polymorphism (SNPs), PD-1.3G/A, PD-1.5C/T, and PD-1.6G/A, were genotyped in 247 VKH patients and 289 age-, sex-, and

  17. Relationship between HTRA1 polymorphism and genetic susceptibility of wet age-related macular degeneration in Han population

    Directory of Open Access Journals (Sweden)

    Nan Yang

    2018-05-01

    Full Text Available AIM: To investigate the relationship between high temperature essential factor A-1(HTRA1polymorphism and genetic susceptibility of wet age-related macular degeneration(AMDin Han population. METHODS: Totally 201 patients of wet AMD in Han population were selected from May 2014 to January 2017 in our hospital as disease group, and 201 healthy persons of Han were selected as health group. Blood samples of peripheral vein were collected and genomic DNA was extracted. HTRA1 polymorphism loci were detected, and the rs11200638 and rs2248799 loci of HTRA1 gene were detected by Sequenom mass spectrometry platform. Then the relationship between HTRA1 polymorphism and genetic susceptibility of wet AMD were analyzed. RESULTS: The grade distributions of the genotype of the rs11200638 and rs2248799 loci in the two groups subjects had significant differences(PPPOR values of rs11200638 genotype AA and AG were respectively 5.36 and 3.45, which were the risk factors of wet AMD(POR values of rs2248799 genotype TT and TC were respectively 2.36 and 1.98, which were the risk factors of wet AMD(PCONCLUSION: The rs11200638 and rs2248799 polymorphisms of HTRA1 gene are associated with the incidence of wet AMD, and the genotype AA and TT are closely related to the risk of wet AMD in Han population, of which the higher frequencies can increase the risk of wet AMD.

  18. The centrality of DSM and non-DSM depressive symptoms in Han Chinese women with major depression

    NARCIS (Netherlands)

    Kendler, K.S.; Aggen, S.H.; Flint, J.; Borsboom, D.; Fried, E.I.

    Introduction: We compared DSM-IV criteria for major depression (MD) with clinically selected non-DSM criteria in their ability to represent clinical features of depression. Method: We conducted network analyses of 19 DSM and non-DSM symptoms of MD assessed at personal interview in 5952 Han Chinese

  19. Recht en vrede bij Hans Kelsen : een herwaardering van Kelsens rechtsfilosofie : juridisch pacifisme als stilzwijgende betekenis van zijn Zuivere Rechtsleer

    NARCIS (Netherlands)

    Notermans, Mathijs Eugène

    2016-01-01

    Hans Kelsen staat in de wereld van de rechtsfilosofie en –theorie bekend als één van de belangrijkste rechtsgeleerden van de 20ste eeuw en zijn belangrijkste werk dat hem die bekendheid heeft opgeleverd, de Reine Rechtslehre, is dan ook ‘wereldberoemd’. Minder bekendheid geniet hij als juridisch

  20. HANS FREUDENTHAL, un matemático en Didáctica y teoría curricular

    NARCIS (Netherlands)

    Gravemeijer, K.P.E.; Terwel, J.

    2000-01-01

    Se describen las principales ideas del trabajo de Hans Freudenthal (1905-1990), el matemático y educador matemático holandés, relacionadas con teoría curricular y didáctica. Se explora el credo educacional de Freudenthal: “la matemática es una actividad humana”. Desde este punto de partida

  1. Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population

    Directory of Open Access Journals (Sweden)

    Ming-Kai Tsai

    2014-01-01

    Full Text Available Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM, including adiponectin (ADIPOQ gene and transcription factor 7-like 2 (TCF7L2, but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan’s Chinese Han population, with our retrospective case-control study genotyping single nucleotide polymorphisms (SNPs in ADIPOQ and TCF7L2 genes both in 149 T2DM patients and in 139 healthy controls from Taiwan. Statistical analysis gauged association of these polymorphisms with risk of T2DM to show ADIPOQ rs1501299 polymorphism variations strongly correlated with T2DM risk (P=0.042, with rs2241766 polymorphism being not associated with T2DM (P=0.967. However, both polymorphisms rs7903146 and rs12255372 of TCF7L2 were rarely detected in Taiwanese people. This study avers that ADIPOQ rs1501299 polymorphism contributes to risk of T2DM in the Taiwanese population.

  2. Beautiful destruction The aesthetic of apocalypse in Hans Dominik's early science fiction

    Directory of Open Access Journals (Sweden)

    Vanessa Cirkel-Bartelt

    2017-11-01

    Full Text Available Though the term ‘science fiction’ was coined somewhat later, the early twentieth century saw an enormous rise in an interest in technological tales set in the near future, mirroring a general awareness of the growing importance of science. Hans Dominik was one of the most prolific – and successful – German authors of this kind of popular literature. According to estimates millions of copies of his books have been sold, making Dominik’s work an interesting case study illustrating the sorts of ideas about science that German-speaking audiences entertained. Being a trained engineer and a public relations officer by profession, Dominik drew heavily on scientific topics that were headline news at the time and yet he also managed to create something new on the basis of these. One of the methods he employed was the use of religious motifs and topoi. Dominik magnified the relevance of scientific enterprises and depicted the consequences of science – or scientific misconduct, rather – as the beginning of a catastrophe, or even an apocalypse. By the same token, Dominik often introduced the figure of the scientist as a protagonist who would save the world. Thus Dominik was able to draw the attention of a large audience to concepts of the use of atomic energy or nuclear weapons – to name only two – and their creative or destructive potential, decades before such devices were technically feasible.

  3. SMAD7 loci contribute to risk of hepatocellular carcinoma and clinicopathologic development among Chinese Han population.

    Science.gov (United States)

    Ji, Jiansong; Xu, Min; Zhao, Zhongwei; Tu, Jianfei; Gao, Jun; Lu, Chenying; Song, Jingjing; Chen, Weiqian; Chen, Minjiang; Fan, Xiaoxi; Cheng, Xingyao; Lan, Xilin; Li, Jie

    2016-04-19

    Genome-wide association studies (GWAS) have identified three loci at 18q21 (rs4939827, rs7240004, and rs7229639), which maps to SMAD7 loci, were associated with risk of diseases of the digestive system. However, their associations with hepatocellular carcinoma (HCC) risk remain unknown. A case-control study was conducted to assess genetic associations with HCC risk and clinicopathologic development among Chinese Han population. Three SNPs were genotyped among 1,000 HCC cases and 1,000 controls using Sequenom Mass-ARRAY technology. We observed statistically significant associations for the three SMAD7 loci and HCC risk. Each copy of minor allele was associated with a 1.24-1.36 fold increased risk of HCC. We also found that significant differences were observed between rs4939827 and clinical TNM stage and vascular invasion, as well as rs7240004 and vascular invasion. We also established a genetic risk score (GRS) by summing the risk alleles. The GRS was significantly associated with increased risk of HCC and vascular invasion. Our data revealed the SMAD7 loci is associated with HCC susceptibility and its clinicopathologic development.

  4. [Association of polymorphisms of NAPE-PLD and FAAH genes with schizophrenia in Chinese Han population].

    Science.gov (United States)

    Si, Peiru; Liu, Shulian; Tong, Dongxiao; Cheng, Meijin; Wang, Liwen; Cheng, Xiaoli

    2018-04-10

    To assess the association of polymorphisms of N-acyl-phosphatidylethanolamine-phospholipase D (DAPE-PLD) and fatty acid amide hydrolase (FAAH) genes, as well as their interaction, with schizophrenia. Polymorphisms of NAPE-PLD rs12540583 and FAAH rs324420, rs2295633, and rs6429600 were determined with PCR - restriction fragment length polymorphism assay and Sanger sequencing. The genotypes of 345 subjects of Han Chinese origin diagnosed with schizophrenia and a 403 controls were compared. The results were analyzed with SPSS 17.0, and the interaction of the two genes was analyzed using a multifactor dimensionality reduction (MDR) method. The frequency of NAPE-PLD rs12540583 polymorphism was significantly different between the two groups under both dominant and additive models (χ2=17.18 vs. χ2=18.94, P<0.0125). The frequencies of AC genotype and C allele of the patient group at rs12540583 were higher than those of the controls, and the interaction of NAPE-PLD and FAAH was associated with schizophrenia. A four-loci model (rs12540583, rs324420, rs2295633 and rs6429600) can best model the interaction between NAPE-PLD and FAAH. The AC genotype and C allele of NAPE-PLD rs12540583 locus are risk factors for schizophrenia, and the interaction between NAPE-PLD rs12540583 and FAAH rs324420, rs2295633 and rs6429600 is associated with schizophrenia.

  5. "Forgotten" Chapters in the History of Transcervical Sterilization: Carl Clauberg and Hans-Joachim Lindemann.

    Science.gov (United States)

    Hildebrandt, Sabine; Benedict, Susan; Miller, Erin; Gaffney, Michael; Grodin, Michael A

    2017-07-01

    Transcervical sterilization is a non-surgical method of permanent female sterilization that is widely used and critically discussed. A review of the historiography of the method reveals that instances of its coercive use are not included in the historical account. This study offers a reexamination of the work of Carl Clauberg and Hans-Joachim Lindemann, to more deeply contextualize within the framework of current usage the coercive use of transcervical sterilization during the Third Reich and in postwar Germany. This inquiry is based on postwar criminal trial records on Clauberg, and on archival documents detailing Lindemann's activities in 1979. A comparative analysis examines arguments by medical historian Karl-Heinz Roth, and identifies shared characteristics and differences between Clauberg and Lindemann, their methods and scientific connections. The results demonstrate that the technique of transcervical sterilization has an abusive potential that may be explained as a function of the person of the physician, of the scientific method itself, and of societal and political influences. The analysis supports the argument that insights from the cases of Clauberg and Lindemann are transferrable geographically and over time, and have the potential to inform current medical practice, such as transcervical sterilization with the Essure device, whose historiographic exploration remains a desideratum. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

    Directory of Open Access Journals (Sweden)

    Ji-peng Wan

    Full Text Available BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP rs11646213 was genotyped by polymerase chain reaction (PCR and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76. Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03 and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13. Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.

  7. Genetic polymorphism of 22 autosomal STR markers in a Han population of Southern China.

    Science.gov (United States)

    Liu, Qiu-Ling; Chen, Zi-Xiang; Chen, Chu-Guang; Lu, De-Jian

    2016-09-01

    Population genetic data and forensic statistics of 22 autosomal short tandem repeat (STR) loci (D1S1656, D2S1338, D3S3045, D4S2366, D5S2500, D6S477, D7S3048, D8S1132, D9S925, D10S1435, D11S2368, D12S391, D13S325, D14S608, D15S659, D16S539, D17S1290, D18S535, D19S253, D20S470, D21S1270 and GATA198B05) were determined for a sample of 515 unrelated individuals from Han population in Southern China. The expected heterozygosity and the discrimination power varied from 0.7358 to 0.8733 and 0.8915 to 0.9702, respectively. The probability of excluding an unrelated man as the true father (assuming no background relatedness in the population) for trios and for duos ranged from 0.5126 to 0.7415 and 0.3331 to 0.5864, respectively. The studied STRs appear to provide a significant improvement in the statistical power of kinship analysis. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  8. Affect recognition across manic and euthymic phases of bipolar disorder in Han-Chinese patients.

    Science.gov (United States)

    Pan, Yi-Ju; Tseng, Huai-Hsuan; Liu, Shi-Kai

    2013-11-01

    Patients with bipolar disorder (BD) have affect recognition deficits. Whether affect recognition deficits constitute a state or trait marker of BD has great etiopathological significance. The current study aims to explore the interrelationships between affect recognition and basic neurocognitive functions for patients with BD across different mood states, using the Diagnostic Analysis of Non-Verbal Accuracy-2, Taiwanese version (DANVA-2-TW) as the index measure for affect recognition. To our knowledge, this is the first study examining affect recognition deficits of BPD across mood states in the Han Chinese population. Twenty-nine manic patients, 16 remitted patients with BD, and 40 control subjects are included in the study. Distinct association patterns between affect recognition and neurocognitive functions are demonstrated for patients with BD and control subjects, implicating alternations in emotion associated neurocognitive processing. Compared to control subjects, manic patients but not remitted subjects perform significantly worse in the recognition of negative emotions as a whole and specifically anger, after adjusting for differences in general intellectual ability and basic neurocognitive functions. Affect recognition deficit may be a relatively independent impairment in BD rather than consequences arising from deficits in other basic neurocognition. The impairments of manic patients in the recognition of negative emotions, specifically anger, may further our understanding of core clinical psychopathology of BD and have implications in treating bipolar patients across distinct mood phases. © 2013 Elsevier B.V. All rights reserved.

  9. Seeking the truth: Hans Blix speaks to CNN's Christiane Amanpour on disarming Iraq

    International Nuclear Information System (INIS)

    Azab Powell, Bonnie

    2004-01-01

    Speaking on the anniversary of the United States' invasion of Iraq, originally declared as a preemptive strike against a madman ready to deploy weapons of mass destruction (WMD), the man first charged with finding those weapons said that the US government has 'the same mind frame as the witch hunters of the past' - looking for evidence to support a foregone conclusion. 'There were about 700 inspections, and in no case did we find weapons of mass destruction,' said Hans Blix, the Swedish diplomat called out of retirement to serve as the United Nations' chief weapons inspector from 2000 to 2003; from 1981 to 1997 he headed the International Atomic Energy Agency (IAEA). 'We went to sites [in Iraq] given to us by intelligence, and only in three cases did we find something' - a stash of nuclear documents, some Vulcan boosters, and several empty warheads for chemical weapons. More inspections were required to determine whether these findings were the 'tip of the iceberg' or simply fragments remaining from that deadly iceberg's past destruction, Blix said he told the United Nations Security Council. However, his work in Iraq was cut short when the United States and the United Kingdom took disarmament into their own hands in March of 2003

  10. Polymorphisms in the CISH gene are associated with susceptibility to tuberculosis in the Chinese Han population.

    Science.gov (United States)

    Ji, Lin-dan; Xu, Wei-nan; Chai, Peng-fei; Zheng, Wei; Qian, Hai-xia; Xu, Jin

    2014-12-01

    A recent multi-center case-control study identified several single nucleotide polymorphisms (SNPs) within the cytokine-inducible SRC homology 2 domain (CISH) gene that are associated with susceptibility to tuberculosis (TB) in both African and Asian populations. To acquire a more robust and well-powered estimate of the putative influence of these SNPs on TB susceptibility, we conducted a well-designed case-control study in the Chinese Han population. We genotyped 3 previously identified SNPs within CISH in 600 patients with pulmonary TB and 618 healthy controls, and we calculated the pooled P-values and ORs of several studies that have also been conducted in the Chinese populations. The results of the case-control study showed that the C allele of rs2239751 and the T allele of rs414171 are associated with TB susceptibility, and this association exists only in women and young adults. The pooled analysis indicated that both SNPs are significantly associated with TB in the global populations and Chinese populations. The current study confirms that variants of CISH are associated with susceptibility to TB, suggesting that negative regulators of cytokine signaling may have a role in immunity against TB infection. We hypothesize that CISH and estrogen may interact in the cytokine-dependent regulation of the immune system. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. SOBRE UNA PROPUESTA DE LECTURAS DE DIEZ CUENTOS DE HANS CHRISTIAN ANDERSEN

    Directory of Open Access Journals (Sweden)

    Ronald Campos López

    2009-01-01

    Full Text Available Se presenta una propuesta metodológica de lecturas de diez cuentos de Hans Christian Andersen, aplicable a una situación de aula de estudiantes de quinto grado de la Escuela de San Rafael de Coronado. Dicho enfoque se orienta desde una perspectiva del valor pragmático de la literatura, en donde el niño y la niña se constituyan a sí mismos como lectores-estudiantesindividuos sociales simultáneamente, a medida que ejecutan su capacidad crítico-analítica, abstracta, simbólica, comparativa, lingüística y representativa sobre la discursividad hegemónica de la identidad y en contra de la dogmática función social del abordaje metodológico cotidiano de los textos literarios aún en las aulas costarricenses. Es por ello que resultan imperativos lecturas y análisis (deconstructivos de textos, literarios propiamente en este caso, los cuales problematicen la institucionalidad del lenguaje en los procesos de enseñanza y aprendizaje.

  12. Prevalence of Zoonotic Intestinal Helminths of Canids in Mog­han Plain, Northwestern Iran

    Directory of Open Access Journals (Sweden)

    M Zare-Bidaki

    2010-06-01

    Full Text Available Background: The present study was aimed to elucidate the status of intestinal hel­minth infec­tions in canids of Moghan Plain, northwestern Iran.Methods: Eighty-five intestine samples from dead or shot wild canids, 59 fecal samples from sheepdogs and 5 from red foxes were collected from 2006 to 2008 and examined in Parasitology department of Pasteur Institute of Iran.Results: Generally, adult worms, larvae, and eggs of 13 species of various parasitic hel­minths were recovered. Necropsy examinations showed that 96.47% animals harbored at least one helminth species. The prevalence of different species in necropsy were Mesoces­toides sp. 84.7%, Rictolaria spp. 55.3%, Macranthorhynchus hirudinaceus 45.9%, Toxocara canis 43.5%, Toxas­caris spp. 35.3%, Joyeuxiella sp. 34.1%; hook­worms; 22.4%, Taenia spp. 11.8%, Alaria spp. 2.4% and Dipylidium caninum 1.2%. Be­sides, eggs belonging to 10 species of parasitic helminths were identified in 46 fecal sam­ples and generally, 30.9% of samples harbored eggs of at least one helminth species.Conclusion: The high prevalence of various helminth infections among canids in Mog­han plain and contamination of environment by helminths eggs may increase the risk of infection for native peo­ple.

  13. CHRONICITY OF DEPRESSION AND MOLECULAR MARKERS IN A LARGE SAMPLE OF HAN CHINESE WOMEN.

    Science.gov (United States)

    Edwards, Alexis C; Aggen, Steven H; Cai, Na; Bigdeli, Tim B; Peterson, Roseann E; Docherty, Anna R; Webb, Bradley T; Bacanu, Silviu-Alin; Flint, Jonathan; Kendler, Kenneth S

    2016-04-25

    Major depressive disorder (MDD) has been associated with changes in mean telomere length and mitochondrial DNA (mtDNA) copy number. This study investigates if clinical features of MDD differentially impact these molecular markers. Data from a large, clinically ascertained sample of Han Chinese women with recurrent MDD were used to examine whether symptom presentation, severity, and comorbidity were related to salivary telomere length and/or mtDNA copy number (maximum N = 5,284 for both molecular and phenotypic data). Structural equation modeling revealed that duration of longest episode was positively associated with mtDNA copy number, while earlier age of onset of most severe episode and a history of dysthymia were associated with shorter telomeres. Other factors, such as symptom presentation, family history of depression, and other comorbid internalizing disorders, were not associated with these molecular markers. Chronicity of depressive symptoms is related to more pronounced telomere shortening and increased mtDNA copy number among individuals with a history of recurrent MDD. As these molecular markers have previously been implicated in physiological aging and morbidity, individuals who experience prolonged depressive symptoms are potentially at greater risk of adverse medical outcomes. © 2016 Wiley Periodicals, Inc.

  14. A case-control study on risk factors of breast cancer in Han Chinese women.

    Science.gov (United States)

    Liu, Li-Yuan; Wang, Fei; Cui, Shu-De; Tian, Fu-Guo; Fan, Zhi-Min; Geng, Cui-Zhi; Cao, Xu-Chen; Yang, Zhen-Lin; Wang, Xiang; Liang, Hong; Wang, Shu; Jiang, Hong-Chuan; Duan, Xue-Ning; Wang, Hai-Bo; Li, Guo-Lou; Wang, Qi-Tang; Zhang, Jian-Guo; Jin, Feng; Tang, Jin-Hai; Li, Liang; Zhu, Shi-Guang; Zuo, Wen-Shu; Yu, Li-Xiang; Xiang, Yu-Juan; Zhou, Fei; Li, Liang; Zhang, Qiang; Fu, Qin-Ye; Ma, Zhong-Bing; Gao, De-Zong; Li, Yu-Yang; Liu, Lu; Ye, Chun-Miao; Wang, Yong-Jiu; Zhou, Wen-Zhong; Yu, Zhi-Gang

    2017-11-14

    This study aimed to investigate risk factors associated with breast cancer among Han Chinese women in northern and eastern China. A matched case-control study involving 1489 patients with breast cancer and 1489 controls was conducted across 21 hospitals in 11 provinces in China, from April 2012 to April 2013. We developed a structured questionnaire to record information from face-to-face interviews with participants. Student's t-tests, Pearson's chi-square tests, and univariate and multivariate conditional logistic regression analyses were used to identify variables with significant differences between the case and control groups. Ten variables were identified (P ratio, menopause, family history of breast cancer, present life satisfaction, sleep satisfaction, milk products, behavior prevention scores, and awareness of breast cancer. We identified a comprehensive range of factors related to breast cancer, among which several manageable factors may contribute to breast cancer prevention. Further prospective studies concerning psychological interventions, sleep regulation, health guidance, and physical exercise are required. A screening model for high-risk populations should be put on the agenda.

  15. Glaciological and chemical studies on ice cores from Hans Tausen ice cap, Greenland

    DEFF Research Database (Denmark)

    Clausen, H.B.; Stampe, Mia; Hammer, C.U.

    2001-01-01

    The paper presents studies of various chemical and isotopical parameters from ice cores drilled in the northernmost located ice cap, Hans Tausen Iskappe, Pearyland, Greenland (HT). The 346 m main core (MC95) was drilled to bedrock in 1995 as well as a 35 m shallow core (SC95). A 60 m shallow core...... (SC75) and a 51 m shallow core (SC76) was drilled at two different positions in 1975 and 1976, respectively. A 6 m shallow core (SC94) was drilled in 1994. Continuous stable isotope records exist for all of these cores, total b-activity only from SC75 and SC76. Continuous ECM inferred acidity records...... exist along the 1995 cores (MC95 and SC95) and finally detailed records of dust and water soluble ion concentrations exist on selected parts of MC95. To determine a time scale for the ice core is an important prerequisite for the interpretation of other records. The age scale is based on acid layers...

  16. Hans Driesch and the problems of "normal psychology". Rereading his Crisis in Psychology (1925).

    Science.gov (United States)

    Allesch, Christian G

    2012-06-01

    In 1925, the German biologist and philosopher Hans Driesch published a booklet entitled The Crisis in Psychology. It was originally published in English and was based on lectures given at various universities in China, Japan and the USA. The "crisis" in psychology of that time, in Driesch's opinion, lies in the necessity to decide about "the road which psychology is to follow in the future". This necessity refers to five "critical points", namely (1) to develop the theory of psychic elements to a theory of meaning by phenomenological analysis, (2) the overcoming of association theory, (3) to acknowledge that the unconscious is a fact and a "normal" aspect of mental life, (4) to reject "psychomechanical parallelism" or any other epiphenomenalistic solution of the mind-body problem, and (5) the extension of psychical research to new facts as described by parapsychology, for instance. Driesch saw close parallels between the development of modern psychology and that of biology, namely in a theoretical shift from "sum-concepts" like association and mechanics, to "totality-concepts" like soul and entelechy. The German translation of 1926 was entitled Grundprobleme der Psychologie (Fundamental Problems of Psychology) while "the crisis in psychology" forms just the subtitle of this book. This underlines that Driesch's argumentation--in contrast to that of Buehler--dealt with ontological questions rather than with paradigms. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. [Study on the excavated wooden carved acupuncture statue of the Western Han Dynasty in Laoguanshan].

    Science.gov (United States)

    Huang, L X

    2017-05-28

    The painted red lines on the wooden carved acupuncture statue of Western Han Dynasty in Laoguanshan, illustrate the running courses of the"eleven meridians"on the body surface in the early meridian doctrine. The carved white lines show the body surface running courses of the"twelve meridians"in the meridian doctrine and the Sanjiao images in Sanjiao doctrine. The dots on the wooden carved acupuncture statue are of two categories, one of them is of regulatory, round and concave spots, which are carved before the process of lacquer undercoat. The other category is of different sizes and in irregular forms, which are carved simultaneously with those white lines. Altogether there are over one hundred dots in these two categories, representing the mai shu (transport point of vessels). The wooden carved acupuncture statue reflects the distinct characteristics on the running courses of meridians, Sanjiao doctrine, the nomenclature and localization of" mai shu "in Bianque medicine, which provides the most powerful evidence for the confirmation of the correlation between Laoguanshan excavated documents and Bianque medicine.

  18. JAK2, MPL, and CALR mutations in Chinese Han patients with essential thrombocythemia.

    Science.gov (United States)

    Wang, Jing; Zhang, Biao; Chen, Bing; Zhou, Rong-Fu; Zhang, Qi-Guo; Li, Juan; Yang, Yong-Gong; Zhou, Min; Shao, Xiao-Yan; Xu, Yong; Xu, Xi-Hui; Ouyang, Jian; Xu, Jingyan; Ye, Qing

    2017-04-01

    Mutations in Janus kinase 2 (JAK2), myeloproliferative leukemia (MPL), and CALR are highly relevant to Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms. Assessing the prevalence of molecular mutations in Chinese Han patients with essential thrombocythemia (ET), and correlating their mutational profile with disease characteristics/phenotype. Of the 110 subjects studied, 62 carried the JAK2 V617F mutation, 21 had CALR mutations, one carried an MPL (W515) mutation, and 28 had non-mutated JAK2, CALR, and MPL (so-called triple-negative ET). Mutations in JAK2 exon 12 were not detected in any patient. Two ET patients had both CALR and JAK2 V617F mutations. Comparing the hematological parameters of the patients with JAK2 mutations with those of the patients with CALR mutations showed that the ET patients with CALR mutations were younger (p = 0.045) and had higher platelet counts (p = 0.043). Genotyping for CALR could be a useful diagnostic tool for JAK2/MPL-negative ET, since the data suggest that CALR is much more prevalent than MPL, therefore testing for CALR should be considered in patients who are JAK2 negative as its frequency is almost 20 times that of MPL mutation.

  19. Between Ideologies and a Hard Place: Hans Magnus Enzensberger's Utopian Pragmatist Poetics

    Directory of Open Access Journals (Sweden)

    Jonathan Monroe

    1997-01-01

    Full Text Available The marginalization of poetry in North American culture makes it difficult to appreciate fully on this side of the Atlantic the importance of Hans Magnus Enzensberger's literary and cultural contributions over the past four decades. Working against familiar cultural encodings that would align poetry uncritically with the "personal" and prose with the "political," his oeuvre makes a strong case for poetry and critical prose as vitally complementary activities. In his 1991 collection of poems, Zukunftsmusik (Future Music and his 1993 prose collection, Civil Wars: From L.A. to Bosnia , Enzensberger renews his longstanding commitment to "the process / of becoming human." Taken together, the two collections suggest the importance of maintaining connections across genres and their constituencies. In the context of the chaotic civil wars and "great migrations" that have shaped global culture since 1989, Enzensberger's thoroughgoing attention to internal differences within language and culture offers a model of hopeful resistance to an increasingly unreflective culture. His recent writing calls us to look carefully into what poetry will become, and for whom, in the wake of 1989.

  20. Mutation rates at 42 Y chromosomal short tandem repeats in Chinese Han population in Eastern China.

    Science.gov (United States)

    Wu, Weiwei; Ren, Wenyan; Hao, Honglei; Nan, Hailun; He, Xin; Liu, Qiuling; Lu, Dejian

    2018-01-31

    Mutation analysis of 42 Y chromosomal short tandem repeats (Y-STRs) loci was performed using a sample of 1160 father-son pairs from the Chinese Han population in Eastern China. The results showed that the average mutation rate across the 42 Y-STR loci was 0.0041 (95% CI 0.0036-0.0047) per locus per generation. The locus-specific mutation rates varied from 0.000 to 0.0190. No mutation was found at DYS388, DYS437, DYS448, DYS531, and GATA_H4. DYS627, DYS570, DYS576, and DYS449 could be classified as rapidly mutating Y-STRs, with mutation rates higher than 1.0 × 10 -2 . DYS458, DYS630, and DYS518 were moderately mutating Y-STRs, with mutation rates ranging from 8 × 10 -3 to 1 × 10 -2 . Although the characteristics of the Y-STR mutations were consistent with those in previous studies, mutation rate differences between our data and previous published data were found at some rapidly mutating Y-STRs. The single-copy loci located on the short arm of the Y chromosome (Yp) showed relatively higher mutation rates more frequently than the multi-copy loci. These results will not only extend the data for Y-STR mutations but also be important for kinship analysis, paternal lineage identification, and family relationship reconstruction in forensic Y-STR analysis.